FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Lande, RG Williams, LB Francis, JL Gragnani, C Morin, ML AF Lande, R. Gregory Williams, Lisa Banks Francis, Jennifer L. Gragnani, Cynthia Morin, Melanie L. TI Efficacy of biofeedback for post-traumatic stress disorder SO COMPLEMENTARY THERAPIES IN MEDICINE LA English DT Article DE PTSD; Biofeedback; Patient satisfaction ID HEART-RATE-VARIABILITY; RELAXATION; ANXIETY; SCALE AB Objective: The authors investigated the potential effectiveness of biofeedback as a complementary treatment for PTSD. Design: This exploratory study used heart variability biofeedback and determined its efficacy in treating PTSD through the use of two rating instruments, The Post-traumatic Stress Disorder Checklist (PCL)-Military version and the Lung Self-Rating Depression Scale. Active duty service members deployed to Iraq or Afghanistan were alternatively assigned to a treatment as usual control group and treatment as usual with the addition of biofeedback. The authors administered the two instruments before treatment and at the conclusion of three weeks of biofeedback therapy. Results: Biofeedback did not produce a measurable improvement. A one way repeated measures analysis of variance (ANOVA) was used to examine change in PCL scores over time. There was a main effect for time, F(1, 36) = 11.98, p < .001, indicating a decrease in PCL scores from baseline to three weeks for both the control and treatment group. Results demonstrated a nonsignificant main effect of group, F(1, 36) = .1.79, p = ns, and a nonsignificant group by time interaction, F(1, 36) = .2.59, p = ns. Similarly, for depression, results showed a significant main effect for time, F(1, 33) = 10.26, p < .003, indicating a decrease in Zung scores from baseline to three weeks for both the control and treatment group. Results demonstrated a nonsignificant main effect of group, F(1, 33) = .385, p = ns, and a nonsignificant group by time interaction, F(1, 33) = 3.52, p = ns. Conclusion: The addition of biofeedback did not produce a measurable improvement in PTSD or depression scores in this exploratory study. Published by Elsevier Ltd C1 [Lande, R. Gregory; Williams, Lisa Banks; Francis, Jennifer L.; Gragnani, Cynthia] Walter Reed Army Med Ctr, Dept Psychiat, Psychiat Continu Serv, Washington, DC 20307 USA. [Morin, Melanie L.] Walter Reed Army Med Ctr, Dept Psychiat, PGY Psychiat Resident 4, Washington, DC 20307 USA. RP Lande, RG (reprint author), 13826 Bison Court, Silver Spring, MD 20906 USA. EM rglande@act85.com NR 18 TC 9 Z9 11 U1 4 U2 16 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0965-2299 J9 COMPLEMENT THER MED JI Complement. Ther. Med. PD DEC PY 2010 VL 18 IS 6 BP 256 EP 259 DI 10.1016/j.ctim.2010.08.004 PG 4 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 707RM UT WOS:000286303700005 PM 21130362 ER PT J AU Gong, P Xie, FL Zhang, BH Perkins, EJ AF Gong, Ping Xie, Fuliang Zhang, Baohong Perkins, Edward J. TI In silico identification of conserved microRNAs and their target transcripts from expressed sequence tags of three earthworm species SO COMPUTATIONAL BIOLOGY AND CHEMISTRY LA English DT Article DE MicroRNA; Expressed sequence tag (EST); Earthworm; Algorithm; Target prediction; Gene ontology; KEGG pathway ID GENES; MIRNAS; GERMLINE; GENOMICS; RNAS AB MicroRNAs are a recently identified class of small regulatory RNAs that target more than 30% protein-coding genes. Elevating evidence shows that miRNAs play a critical role in many biological processes, including developmental timing, tissue differentiation, and response to chemical exposure. In this study, we applied a computational approach to analyze expressed sequence tags, and identified 32 miRNAs belonging to 22 miRNA families, in three earthworm species Eisenia fetida, Eisenia andrei, and Lumbricus rubellus. These newly identified earthworm miRNAs possess a difference of 2-4 nucleotides from their homologous counterparts in Caenorhabditis elegans. They also share similar features with other known animal miRNAs, for instance, the nucleotide U being dominant in both mature and pre-miRNA sequences, particularly in the first position of mature miRNA sequences at the 5' end. The newly identified earthworm miRNAs putatively regulate mRNA genes that are involved in many important biological processes and pathways related to development, growth, locomotion, and reproduction as well as response to stresses, particularly oxidative stress. Future efforts will focus on experimental validation of their presence and target mRNA genes to further elucidate their biological functions in earthworms. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Gong, Ping] SpecPro Inc, Environm Serv, Vicksburg, MS 39180 USA. [Xie, Fuliang; Zhang, Baohong] E Carolina Univ, Dept Biol, Greenville, NC 27858 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), SpecPro Inc, Environm Serv, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@usace.army.mil; xief@ecu.edu; zhangb@ecu.edu; edward.j.perkins@usace.army.mil RI Zhang, Baohong/O-4948-2016 FU U.S. Army FX This work was supported by the U.S. Army Environmental Quality Technology Basic Research Program. Permission to publish this information was granted by the Chief of Engineers. NR 39 TC 4 Z9 4 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1476-9271 EI 1476-928X J9 COMPUT BIOL CHEM JI Comput. Biol. Chem. PD DEC PY 2010 VL 34 IS 5-6 BP 313 EP 319 DI 10.1016/j.compbiolchem.2010.09.004 PG 7 WC Biology; Computer Science, Interdisciplinary Applications SC Life Sciences & Biomedicine - Other Topics; Computer Science GA 694VO UT WOS:000285327300007 PM 21030313 ER PT J AU Mondello, S Bullock, R Brophy, G Buki, A Streeter, J Schmid, K Tortella, F Hayes, R Wang, K AF Mondello, Stefania Bullock, Ross Brophy, Gretchen Buki, Andras Streeter, Jacskon Schmid, Kara Tortella, Frank Hayes, Ronald Wang, Kevin TI MICROTUBULE-ASSOCIATED PROTEIN-2: A NEW SENSITIVE AND SPECIFIC MARKER FOR TRAUMATIC BRAIN INJURY SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 40th Critical Care Congress CY JAN 15-19, 2011 CL San Diego, CA SP Soc Crit Care Med C1 [Mondello, Stefania] Univ Florida, Gainesville, FL 32611 USA. [Bullock, Ross] Univ Miami, Coral Gables, FL 33124 USA. [Brophy, Gretchen] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Buki, Andras] Univ Pecs, Pecs, Hungary. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2010 VL 38 IS 12 SU S MA 36 BP U11 EP U11 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 684BA UT WOS:000284520800037 ER PT J AU Winter, L AF Winter, Lucas TI Fragile State: Yemen in Conflict SO CURRENT HISTORY LA English DT Editorial Material C1 USA, Foreign Mil Studies Off, Washington, DC 20310 USA. RP Winter, L (reprint author), USA, Foreign Mil Studies Off, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 USA SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD DEC PY 2010 VL 109 IS 731 BP 395 EP 400 PG 6 WC International Relations; Political Science SC International Relations; Government & Law GA 694FO UT WOS:000285280600006 ER PT J AU Kramer, MK Kriska, AM Venditti, EM Semler, LN Miller, RG McDonald, T Siminerio, LM Orchard, TJ AF Kramer, M. Kaye Kriska, Andrea M. Venditti, Elizabeth M. Semler, Linda N. Miller, Rachel G. McDonald, Teresa Siminerio, Linda M. Orchard, Trevor J. TI A novel approach to diabetes prevention: Evaluation of the Group Lifestyle Balance program delivered via DVD SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Article DE Diabetes prevention; CVD risk; Lifestyle intervention; Diabetes Prevention Program; Group Lifestyle Balance; Translation ID INTERVENTION; COMMUNITY; METFORMIN AB This pilot project evaluated the Group Lifestyle Balance program (GLB), an adaptation of the DPP lifestyle intervention, delivered via DVD with remote participant support provided by the University of Pittsburgh Diabetes Prevention Support Center. Results suggest that GLB-DVD with remote support may provide an effective alternative for GLB delivery. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Kramer, M. Kaye; Kriska, Andrea M.; Miller, Rachel G.; Orchard, Trevor J.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA. [Venditti, Elizabeth M.] Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA. [Semler, Linda N.] Univ Pittsburgh, Sch Educ, Pittsburgh, PA 15203 USA. [McDonald, Teresa] N Coast Family Med Clin, Ft Bragg, CA 95437 USA. [Siminerio, Linda M.] Univ Pittsburgh, Sch Med & Nursing, Pittsburgh, PA 15203 USA. RP Kramer, MK (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, 3512 5th Ave, Pittsburgh, PA 15213 USA. EM mkk3@pitt.edu OI Kriska, Andrea/0000-0002-3522-0869; orchard, trevor/0000-0001-9552-3215 FU Air Force Surgeon General's Office [W81XWH-07-2-0080] FX We would like to acknowledge the United States Air Force Center of Excellence for Medical Multimedia for collaboration in creating the GLB-DVD, as well as the prevention professionals that implemented this project. This material is based on research sponsored by The Air Force Surgeon General's Office under agreement number W81XWH-07-2-0080. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of The Air Force Surgeon General's Office or the U.S. Government. NR 8 TC 35 Z9 35 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD DEC PY 2010 VL 90 IS 3 BP E60 EP E63 DI 10.1016/j.diabres.2010.08.013 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 698XU UT WOS:000285629300005 PM 20863586 ER PT J AU Kawamura, Y Yoshikawa, I Katakura, K AF Kawamura, Yuta Yoshikawa, Isao Katakura, Ken TI Imported Leishmaniasis in Dogs, US Military Bases, Japan SO EMERGING INFECTIOUS DISEASES LA English DT Letter C1 [Katakura, Ken] Hokkaido Univ, Parasitol Lab, Dept Dis Control, Grad Sch Vet Med,Kita Ku, Sapporo, Hokkaido 0600818, Japan. [Yoshikawa, Isao] US Army Japan Dist Vet Command, Zama Branch, Kanagawa, Japan. RP Katakura, K (reprint author), Hokkaido Univ, Parasitol Lab, Dept Dis Control, Grad Sch Vet Med,Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan. NR 9 TC 3 Z9 3 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2010 VL 16 IS 12 BP 2017 EP 2019 DI 10.3201/eid1612.100389 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 690TM UT WOS:000285031100045 PM 21122254 ER PT J AU Li, D Fortner, JD Johnson, DR Chen, C Li, QL Alvarez, PJJ AF Li, Dong Fortner, John D. Johnson, David R. Chen, Chun Li, Qilin Alvarez, Pedro J. J. TI Bioaccumulation of C-14(60) by the Earthworm Eisenia fetida SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; FULLERENE C-60 NANOPARTICLES; NATURAL ORGANIC-MATTER; CARBON NANOTUBES; C-14-LABELED C-60; WATER SUSPENSION; HUMIC-ACID; FOETIDA; SOIL; CHEMICALS AB Carbon fullerenes, including buckminsterfullerene (C-60), are increasingly available for numerous applications, thus increasing the likelihood of environmental release. This calls for information about their bioavailability and bioaccumulation potential. In this study, C-14-labeled C-60 and C-14-phenanthrene (positive control) were added separately to soils of varying composition and organic carbon content (OC), and their bioaccumulation in the earthworm Eisenia fetida was compared. Biota-sediment accumulation factors (BSAF) were measured after 24 h depuration in soils with high C-60 dosages (60, 100, and 300 mg-C-60 kg(-1) dry soil), which exceed the soil sorption capacity, as well as in soils with a low C-60 dose (0.25 mg kg(-1)) conducive to a high fraction of sorbed molecular C-60. The BSAF value for the low-dose soil (0.427) was 1 order of magnitude lower than for less hydrophobic phenanthrene (7.83), inconsistent with the equilibrium partition theory that suggests that BSAF should be constant and independent of the K-OW value of the chemical. Apparently, the large molecular size of C-60 hinders uptake and bioaccumulation. Lower BSAF values (0.065-0.13) were measured for high-dose soils, indicating that C-60 bioaccumulates more readily when a higher fraction of molecular C-60 (rather than larger precipitates) is available. For the high-dose tests (heterogeneous C-60 system), soil OC content did not significantly affect the extent of C-60 bioaccumulation after 28 d of incubation, although higher DC content resulted in faster initial bioaccumulation. For low-dose soils, C-60 BSAF decreased with increasing soil DC, as commonly reported for hydrophobic chemicals clue to partitioning into soil OC. There was no detectable transformation of C-14(60) in either soil or worm tissue. Overall, the relatively low extent but rapid bioaccumulation of C-60 in E. fetida suggests the need for further studies on the potential for trophic transfer and biomagnification. C1 [Li, Dong; Li, Qilin; Alvarez, Pedro J. J.] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. [Fortner, John D.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Johnson, David R.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Chen, Chun] Nankai Univ, Coll Environm Sci & Engn, Minist Educ, Key Lab Pollut Proc & Environm Criteria, Tianjin 300071, Peoples R China. RP Alvarez, PJJ (reprint author), Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. EM alvarez@rice.edu RI Fortner, John/A-9810-2012 FU National Science Foundation [R3B520]; Center for Biological and Environmental Nanotechnology through the Nanoscale Science and Engineering Initiative of the National Science Foundation [EEC-0647452] FX We thank Robert Boyd (ERDC) for helping with worm culture setup and husbandry, Mason Tomson for providing Lula soil, and Ronald Carmona for technical assistance. This work was supported by a National Science Foundation award (R3B520) and the Center for Biological and Environmental Nanotechnology through the Nanoscale Science and Engineering Initiative of the National Science Foundation (EEC-0647452). NR 52 TC 30 Z9 32 U1 3 U2 60 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 1 PY 2010 VL 44 IS 23 BP 9170 EP 9175 DI 10.1021/es1024405 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 684CA UT WOS:000284523400061 PM 21049992 ER PT J AU Stanley, JK Kennedy, AJ Farrar, JD Mount, DR Steevens, JA AF Stanley, Jacob K. Kennedy, Alan J. Farrar, J. Daniel Mount, David R. Steevens, Jeffery A. TI EVALUATION OF REDUCED SEDIMENT VOLUME PROCEDURES FOR ACUTE TOXICITY TESTS USING THE ESTUARINE AMPHIPOD LEPTOCHEIRUS PLUMULOSUS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Leptochetrus plumulosus; Sediment volume; Lead; Polycyclic aromatic hydrocarbon; Test method ID MODEL AB The volume of sediment required to perform a sediment toxicity bioassay is a major driver of the overall cost associated with that bioassay Sediment volume affects bioassay cost because of sediment collection transportation storage and disposal costs as well as labor costs associated with organism recovery at the conclusion of the exposure The objective of the current study was to evaluate reduced sediment volume versions of the standard U S Environmental Protection Agency (U S EPA) 10 d acute Leptocheirus plumulosus method that uses a beaker size of 1 000 ml and 20 organisms The test design used evaluated the effects of beaker size (250 and 100 ml) and associated sediment volume (75 and 30ml respectively) as well as organism loading density (10 and 20 organisms) on test endpoint responsiveness relative to the standard 10 d test method These comparisons were completed with three different types of contaminated sediments a field collected polycyclic aromatic hydrocarbon (PAH) contaminated sediment a lead spiked control sediment and a control sediment spiked with mineral oil Assessment criteria included test endpoint sensitivity endpoint consistency statistical power water quality and logistical assessments Results indicate that the current U S EPA method is preferable to the reduced sediment volume methods we assessed but that a 250 ml beaker/10 organism experimental design is of comparable utility and may be advantareous when reduced sediment volumes are desirable because of high contaminant (spiking studies) or sediment disposal costs In addition the results of the current study provide toxicity reference values for PAHs lead and an oil surrogate for petroleum hydrocarbons Environ Toxicol Chem 2010 29 2769-2776 (C) 2010 SETAC C1 [Stanley, Jacob K.; Kennedy, Alan J.; Farrar, J. Daniel; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Mount, David R.] US EPA, Off Res & Dev, Environm Effects Res Lab, Duluth, MN 55804 USA. RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. FU U S Army Corps of Engineers Dredging Operations Environmental Research (DOER) FX The views expressed are those of the authors and do not necessarily reflect the policy positions of the U S EPA Mention of trade names or commercial products does not constitute endorsement or recommendation for use Permission has been granted by the Chief of Engineers to publish this material Funding for this work came from the U S Army Corps of Engineers Dredging Operations Environmental Research (DOER) program (Todd S Bridges Program Manager) The authors thank Jamma Williams Jennifer Goss and Jerre Sims of the US Army Engineer Research and Development Center s Environmental Laboratory and J Russell Hockett and Correne T Jenson of the U S EPA s Office of Research and Development for technical support NR 17 TC 4 Z9 4 U1 0 U2 6 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2010 VL 29 IS 12 BP 2769 EP 2776 DI 10.1002/etc.333 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 686FW UT WOS:000284683200017 PM 20890914 ER PT J AU Kerr, R Holladay, S Jarrett, T Selcer, B Meldrum, B Williams, S Tannenbaum, L Holladay, J Williams, J Gogal, R AF Kerr, Richard Holladay, Steven Jarrett, Timothy Selcer, Barbara Meldrum, Blair Williams, Susan Tannenbaum, Lawrence Holladay, Jeremy Williams, Jamie Gogal, Robert TI LEAD PELLET RETENTION TIME AND ASSOCIATED TOXICITY IN NORTHERN BOBWHITE QUAIL (COLINUS VIRGINIANUS) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Lead; Avian; Ventriculus; Retention; d ALAD ID BLOOD CHARACTERISTICS; RISK-ASSESSMENT; MOURNING DOVES; EXPOSURE; ACID; SHOT; TOXICOSIS; CHICKEN; RANGE; LEVEL AB Birds are exposed to Pb by oral ingestion of spent Pb shot as grit A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract In the current study northern bobwhite quail (Colinus virginianus) were orally gavaged with I 5 or 10 Pb shot pellets of 2 mm diameter and radiographically followed over time Blood Pb levels and other measures of toxicity were collected to correlate with pellet retention Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks I and 2 and were removed from further study Most of the Pb pellets were absorbed or excreted within 14 d of gavage Independent of dose Pellet sue in the ventriculus decreased over time in radiographs suggesting dissolution caused by the acidic pH Birds dosed with one pellet showed mean blood Pb levels that exceeded 1300 mu/dl at week 1 further supporting dissolution in the gastrointestinal tract Limited signs of toxicity were seen in the one pellet birds however plasma delta aminolevulinic acid dehydratase (d ALAD) activity was persistently depressed suggesting possible impaired hematological function Environ Tomol Chem 2010 29 2869-2874 (C) 2010 SETAC C1 [Kerr, Richard; Holladay, Steven; Jarrett, Timothy; Selcer, Barbara; Holladay, Jeremy; Williams, Jamie; Gogal, Robert] Univ Georgia, Coll Vet Med, Dept Anat & Radiol, Athens, GA 30602 USA. [Meldrum, Blair] Virginia Tech, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA USA. [Williams, Susan] Univ Georgia, Coll Vet Med, Dept Populat Hlth, Athens, GA 30602 USA. [Tannenbaum, Lawrence] USA, Ctr Hlth Promot & Prevent Med, Aberdeen, MD USA. RP Gogal, R (reprint author), Univ Georgia, Coll Vet Med, Dept Anat & Radiol, Athens, GA 30602 USA. NR 22 TC 7 Z9 7 U1 3 U2 14 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2010 VL 29 IS 12 BP 2869 EP 2874 DI 10.1002/etc.355 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 686FW UT WOS:000284683200030 PM 20836061 ER PT J AU Huang, CJ Webb, HE Evans, RK McCleod, KA Tangsilsat, SE Kamimori, GH Acevedo, EO AF Huang, Chun-Jung Webb, Heather E. Evans, Ronald K. McCleod, Kelly A. Tangsilsat, Supatchara E. Kamimori, Gary H. Acevedo, Edmund O. TI Psychological stress during exercise: immunoendocrine and oxidative responses SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article DE psychological stress; exercise; catecholamines; interleukin-2; oxidative stress; 8-isoprostane ID PROLONGED EXERCISE; MENTAL STRESS; DNA-DAMAGE; FIREFIGHTERS; HORMONES; GLUCOCORTICOIDS; CHALLENGE; DISEASE AB The purpose of this study was to examine the changes in catecholamines (epinephrine [EPI] and norepinephrine [NE]), interleukin-2 (IL-2) and a biomarker of oxidative stress (8-isoprostane) in healthy individuals who were exposed to a dual challenge (physical and psychological stress). Furthermore, this study also examined the possible relationships between catecholamines (NE and EPI) and 8-isoprostane and between IL-2 and 8-isoprostane following a combined physical and psychological challenge. Seven healthy male subjects completed two experimental conditions. The exercise-alone condition (EAC) consisted of cycling at 60% VO(2max) for 37 min, while the dual-stress condition (DSC) included 20 min of a mental challenge while cycling. DSC showed greater EPI and 8-isoprostane levels (significant condition by time interaction). NE and IL-2 revealed significant change across time in both conditions. In addition, following dual stress, EPI area-under-the-curve (AUC) demonstrated a positive correlation with NE AUC and IL-2 AUC. NE AUC was positively correlated with IL-2 AUC and peak 8-isoprostane, and peak IL-2 was positively correlated with peak 8-isoprostane in response to a dual stress. The potential explanation for elevated oxidative stress during dual stress may be through the effects of the release of catecholamines and IL-2. These findings may further provide the potential explanation that dual stress alters physiological homeostasis in many occupations including firefighting, military operations and law enforcement. A greater understanding of these responses to stress can assist in finding strategies (e.g. exercise training) to overcome the inherent psychobiological challenges associated with physically and mentally demanding professions. C1 [Huang, Chun-Jung] Florida Atlantic Univ, Boca Raton, FL 33431 USA. [Webb, Heather E.] Mississippi State Univ, Starkville, MS USA. [Evans, Ronald K.; Acevedo, Edmund O.] Virginia Commonwealth Univ, Richmond, VA USA. [McCleod, Kelly A.; Tangsilsat, Supatchara E.] Univ New S Wales, Sydney, NSW, Australia. [Kamimori, Gary H.] USA, Inst Res, Silver Spring, MD USA. RP Huang, CJ (reprint author), 777 Glades Rd,Field House 11-24D, Boca Raton, FL 33431 USA. EM chuang5@fau.edu RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 NR 37 TC 16 Z9 16 U1 2 U2 12 PU SOC EXPERIMENTAL BIOLOGY MEDICINE PI MAYWOOD PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD DEC PY 2010 VL 235 IS 12 BP 1498 EP 1504 DI 10.1258/ebm.2010.010176 PG 7 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 702OW UT WOS:000285905000014 PM 21127346 ER PT J AU McCarthy-Keith, DM Schisterman, EF Robinson, RD O'Leary, K Lucidi, RS Armstrong, AY AF McCarthy-Keith, Desiree M. Schisterman, Enrique F. Robinson, Randal D. O'Leary, Kathleen Lucidi, Richard S. Armstrong, Alicia Y. TI Will decreasing assisted reproduction technology costs improve utilization and outcomes among minority women? SO FERTILITY AND STERILITY LA English DT Article DE ART utilization; ethnic disparity; infertility ID IN-VITRO FERTILIZATION; INSURANCE MANDATES; RACIAL DISPARITIES; AFRICAN-AMERICAN; WHITE WOMEN; BLACK-WOMEN; INFERTILITY; CARE; SERVICES; COVERAGE AB Objective: To evaluate assisted reproduction technology (ART) usage and outcomes in minority women seeking care at enhanced access, military ART programs. Design: Retrospective cohort. Setting: Federal ART programs. Patient(s): Two thousand fifty women undergoing first cycle, fresh, nondonor ART from 2000 to 2005. Intervention(s): None. Main Outcome Measure(s): Rate of ART use, clinical pregnancy rate, live birth rate. Result(s): African American women had an almost fourfold increased use of ART and Hispanic women had decreased use. Clinical pregnancy rates were significantly lower for African American women compared with white women (46.1% vs. 52.6%, relative risk [RR] 0.88; 95% confidence interval [CI], 0.78-0.99) as were live birth rates (33.7%. vs. 45.7%, RR 0.74; 95% CI, 0.63-0.91). Conclusion(s): Economics appear to influence ART use by African American women but not Hispanic women. Despite increased use by African American women, outcomes in this group were worse when compared with Caucasian women. Improving access through decreased cost may increase use by some but not all minority groups. Improved access may not translate into improved outcomes in some ethnic groups. (Fertil Steril (R) 2010; 94: 2587-9. (C) 2010 by American Society for Reproductive Medicine.) C1 [McCarthy-Keith, Desiree M.; Armstrong, Alicia Y.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA. [McCarthy-Keith, Desiree M.; Armstrong, Alicia Y.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Schisterman, Enrique F.; O'Leary, Kathleen] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, NIH, Bethesda, MD 20892 USA. [Robinson, Randal D.] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Wilford Hall Med Ctr, San Antonio, TX USA. [Lucidi, Richard S.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Armstrong, AY (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bldg 10,CRC Room 1E-1-3140,10 Ctr Dr MSC 1109, Bethesda, MD 20892 USA. EM armstroa@mail.nih.gov OI Schisterman, Enrique/0000-0003-3757-641X FU Eunice Kennedy Shriver National Institute of Child Health and Human Development FX Supported in part by the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development. NR 20 TC 17 Z9 17 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD DEC PY 2010 VL 94 IS 7 BP 2587 EP 2589 DI 10.1016/j.fertnstert.2010.02.021 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 684TV UT WOS:000284573700021 PM 20356585 ER PT J AU Banks, NK Norian, JM Bundorf, MK Henne, MB AF Banks, Nicole K. Norian, John M. Bundorf, M. Kate Henne, Melinda B. TI Insurance mandates, embryo transfer, outcomes-the link is tenuous SO FERTILITY AND STERILITY LA English DT Editorial Material DE Health insurance mandates; embryo transfer; multiple births; IVF outcomes ID ASSISTED-REPRODUCTIVE-TECHNOLOGY; IN-VITRO FERTILIZATION; MULTIPLE BIRTHS; COVERAGE; NUMBER; IMPACT AB To examine the relationship between state insurance mandate status and the number of embryos transferred in assisted reproductive technology cycles, we conducted a retrospective analysis of clinics reporting to the publicly available national Society for Assisted Reproductive Technology registry. We found that clinics in states with comprehensive mandates transferred between 0.210 and 0.288 fewer embryos per cycle depending upon patient age, and were more likely to transfer fewer embryos than recommended for older women; however, the relationship between state mandate status and clinic birth and multiple birth rates varied by age group. (Fertil Steril (R) 2010; 94:2776-9. (C) 2010 by American Society for Reproductive Medicine.) C1 [Henne, Melinda B.] Walter Reed Army Med Ctr, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Bundorf, M. Kate] Stanford Univ, Dept Hlth Res & Policy, Stanford, CA 94305 USA. [Norian, John M.; Henne, Melinda B.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. [Norian, John M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Reprod Biol & Med Branch, NIH, Bethesda, MD USA. [Banks, Nicole K.] Georgetown Univ Hosp, Washington, DC 20007 USA. RP Henne, MB (reprint author), Walter Reed Army Med Ctr, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, 6900 Georgia Ave NW,Bldg 1,Room A226, Washington, DC 20307 USA. EM Melinda.Henne@amedd.army.mil NR 21 TC 6 Z9 6 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD DEC PY 2010 VL 94 IS 7 BP 2776 EP 2779 DI 10.1016/j.fertnstert.2010.05.037 PG 4 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 684TV UT WOS:000284573700067 PM 20579988 ER PT J AU Stephenson, JR Gingerich, AJ Brown, RS Pflugrath, BD Deng, ZQ Carlson, TJ Langeslay, MJ Ahmann, ML Johnson, RL Seaburg, AG AF Stephenson, John R. Gingerich, Andrew J. Brown, Richard S. Pflugrath, Brett D. Deng, Zhiqun Carlson, Thomas J. Langeslay, Mike J. Ahmann, Martin L. Johnson, Robert L. Seaburg, Adam G. TI Assessing barotrauma in neutrally and negatively buoyant juvenile salmonids exposed to simulated hydro-turbine passage using a mobile aquatic barotrauma laboratory SO FISHERIES RESEARCH LA English DT Article DE Hydropower; Chinook salmon; Barotrauma; Injuries; Physostomous ID GAS SUPERSATURATION; SURVIVAL; FISH; DECOMPRESSION AB Barotrauma-injuries sustained following rapid decompression occur in many different fisheries applications Previous attempts to quantify barotrauma in fish have been limited by the functionality of hypo/hyperbaric systems Further field studies often are confounded by covariates The mobile aquatic barotrauma laboratory (MARL) was designed to address these limitations Specifically this testing facility allows the user to evaluate similar complex pressure scenarios to which migrating juvenile salmonids are exposed following turbine or spillway passage In this paper we describe the MABL and present a case study in which negative and neutrally buoyant juvenile Chinook salmon were exposed to simulated hydro-turbine passage (STP) The severity of the decompression profile and the fish s ability to gain neutral buoyancy were used as predictor variables We determined that following STP fish that achieved neutral buoyancy during a 16-h acclimation period had a greater risk of mortality and injury emboli swim bladder rupture and internal hemorrhaging) than negatively buoyant conspecifics This research solidifies the need to allow fish to become neutrally buoyant when assessing barotrauma and mortality in field and laboratory applications Future research examining injury and mortality of turbine-passed fish needs to consider the fish s buoyancy to more appropriately evaluate these endpoints (C) 2010 Elsevier B V All rights reserved C1 [Stephenson, John R.; Gingerich, Andrew J.; Brown, Richard S.; Pflugrath, Brett D.; Deng, Zhiqun; Carlson, Thomas J.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Langeslay, Mike J.] USA, Corps Engn, Portland, OR 97208 USA. [Ahmann, Martin L.; Johnson, Robert L.] USA, Corps Engn, Walla Walla, WA 99362 USA. [Seaburg, Adam G.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA. RP Stephenson, JR (reprint author), Pacific NW Natl Lab, Post Off Box 999, Richland, WA 99352 USA. RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U S Army Corps of Engineers Portland District; U S Department of Energy [DE-AC05-76RL01830] FX Funding was provided by the U S Army Corps of Engineers Portland District The authors thank the commitment and oversight of the U S Army Corps of Engineers Turbine Survival Technical Team We appreciate the assistance of Andrea Currie Joanne Duncan Ben Tice Jake Tucker Abby Welch Piper Benjamin Carmina Arimescu Andrea Le Barge Jennifer Panther Jill Janak Gayle Dirkes Bob Mueller and Marie-Helene Theriault The authors thank the staff of Reimers Systems Inc The Pacific Northwest National Laboratory animal facilities used in this research are AAALAC-certified fish were handled in accordance with federal guidelines for the care and use of laboratory animals and protocols for our study were approved by the Institutional Animal Care and Use Committee at Battelle-Pacific Northwest Division The Pacific Northwest National Laboratory is operated by Battelle for the U S Department of Energy under Contract DE-AC05-76RL01830 NR 28 TC 31 Z9 31 U1 1 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 EI 1872-6763 J9 FISH RES JI Fish Res. PD DEC PY 2010 VL 106 IS 3 BP 271 EP 278 DI 10.1016/j.fishres.2010.08.006 PG 8 WC Fisheries SC Fisheries GA 691JW UT WOS:000285077100003 ER PT J AU Pavelites, JJ Kintzele, D Fotia, P Prahlow, JA AF Pavelites, Joseph J. Kintzele, David Fotia, Paul Prahlow, Joseph A. TI Death by black powder revolver: a case report SO FORENSIC SCIENCE MEDICINE AND PATHOLOGY LA English DT Article DE Black powder; Hand gun; Ballistics; Wound ID HANDGUN AB Deaths resulting from the use of black powder handguns are relatively uncommon compared to other firearms. We report the case of a 48 year-old woman who sustained a lethal gunshot wound to the face from a black powder revolver. Autopsy revealed extensive soot and powder deposition around the entrance wound between the right eye and nose with perforation of the skull and brain. The exit wound also contained evidence of soot. Discussion of this characteristic pattern of discharge deposition from black powder weapons is presented. C1 [Pavelites, Joseph J.] Dwight D Eisenhower Army Med Ctr, GME Off, Transit Year Program, Ft Gordon, GA 30905 USA. [Kintzele, David; Fotia, Paul] Indiana State Police Lab, Lowell, IN 46356 USA. [Prahlow, Joseph A.] S Bend Med Fdn, South Bend, IN 46601 USA. [Prahlow, Joseph A.] Univ Notre Dame, Indiana Univ Sch Med S Bend, South Bend, IN 46617 USA. RP Pavelites, JJ (reprint author), Dwight D Eisenhower Army Med Ctr, GME Off, Transit Year Program, Bldg 300,Hosp Rd, Ft Gordon, GA 30905 USA. EM joseph.pavelites@us.army.mil NR 12 TC 3 Z9 3 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1547-769X J9 FORENSIC SCI MED PAT JI Forensic Sci. Med. Pathol. PD DEC PY 2010 VL 6 IS 4 BP 298 EP 303 DI 10.1007/s12024-010-9177-6 PG 6 WC Medicine, Legal; Pathology SC Legal Medicine; Pathology GA 651SY UT WOS:000281948600010 PM 20577911 ER PT J AU Reddy, KR Shiffman, ML Rodriguez-Torres, M Cheinquer, H Abdurakhmanov, D Bakulin, I Morozov, V Silva, GF Geyvandova, N Stanciu, C Rabbia, M McKenna, M Thommes, JA Harrison, SA AF Reddy, K. Rajender Shiffman, Mitchell L. Rodriguez-Torres, Maribel Cheinquer, Hugo Abdurakhmanov, Djamal Bakulin, Igor Morozov, Viacheslav Silva, Giovanni Faria Geyvandova, Natalia Stanciu, Carol Rabbia, Michael McKenna, Michael Thommes, James A. Harrison, Stephen A. CA PROGRESS Study Investigators TI Induction Pegylated Interferon Alfa-2a and High Dose Ribavirin Do Not Increase SVR in Heavy Patients With HCV Genotype 1 and High Viral Loads SO GASTROENTEROLOGY LA English DT Article DE Chronic Hepatitis C; Tolerability of High-Dose Pegylated Interferon; Steatosis and Response to HCV Therapy; Tolerability of High-Dose Ribavirin ID CHRONIC HEPATITIS-C; PEGINTERFERON ALPHA-2A; PLUS RIBAVIRIN; VIROLOGICAL RESPONSE; COMBINATION THERAPY; INSULIN-RESISTANCE; STEATOSIS; TRIAL; RETREATMENT; PROGRESSION AB BACKGROUND & AIMS: Patients infected with hepatitis C virus (HCV) genotype 1, body weight >= 85 kg, and high baseline viral load respond poorly to standard doses of pegylated interferon (peginterferon) and ribavirin. We evaluated intensified therapy with peginterferon alfa-2a plus ribavirin. METHODS: This double-blind randomized trial included HCV genotype 1-infected outpatients from hepatology clinics with body weight >= 85 kg and HCV RNA titer >= 400,000 IU/mL. Patients were randomized to 180 mu g/wk peginterferon alfa-2a for 48 weeks plus 1200 mg/day ribavirin (standard of care) (group A, n = 191) or 1400/1600 mg/day ribavirin (group B, n = 189). Additional groups included 360 mu g/wk peginterferon alfa-2a for 12 weeks then 180 mu g/wk peginterferon alfa-2a for 36 weeks plus 1200 mg/day ribavirin (group C, n = 382) or 1400/1600 mg/day ribavirin (group D, n = 383). Follow-up lasted 24 weeks after treatment. RESULTS: Sustained virologic response rates (HCV RNA level <15 IU/mL at end of follow-up) in groups A, B, C, and D were 38%, 43%, 44%, and 41%, respectively. There were no significant differences among the 4 groups or between pooled peginterferon alfa-2a regimens (A + B vs C + D: odds ratio [OR], 1.08; 95% confidence interval [CI], 0.83-1.39; P = .584) or pooled ribavirin regimens (A + C vs B + D: OR, 1.00; 95% CI, 0.79 1.28; P = .974). CONCLUSIONS: In patients infected with HCV genotype 1 who are difficult to treat (high viral load, body weight >= 85 kg), a 12-week induction regimen of peginterferon alfa-2a and/or higher-dose ribavirin is not more effective than the standard regimen. C1 [Reddy, K. Rajender] Univ Penn, Div Gastroenterol, Philadelphia, PA 19104 USA. [Shiffman, Mitchell L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA. [Rodriguez-Torres, Maribel] Fdn Invest Diego Santurce, Santurce, PR USA. [Cheinquer, Hugo] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil. [Abdurakhmanov, Djamal] Moscow Med Acad, Moscow, Russia. [Bakulin, Igor] Dept Gastroenterol, Samara, Russia. [Bakulin, Igor] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia. [Silva, Giovanni Faria] Botucatu Sch Med, Botucatu, SP, Brazil. [Geyvandova, Natalia] 1 Stavropol State Med Acad, Stavropol, Russia. [Stanciu, Carol] Gastroenterol & Hepatol Inst, Iasi, Romania. [Rabbia, Michael; Thommes, James A.] Roche, Nutley, NJ USA. [McKenna, Michael] Roche, Welwyn Garden City, England. [Harrison, Stephen A.] Brooke Army Med Ctr, Houston, TX USA. RP Reddy, KR (reprint author), Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA. EM rajender.reddy@uphs.upenn.edu RI Bakulin, I. G./P-4453-2014 OI Bakulin, I. G./0000-0002-6151-2021 FU Roche; Gilead Sciences, Inc; Tibotec; Bristol-Myers Squibb; Vertex Pharmaceuticals; Merck Co, Inc; Boehringer Ingelheim; Exalenz; Biolex; Celera Diagnostics; LLC; Conatus Pharmaceuticals; Gilead Sciences Inc; GlaxoSmithKline; GlobeImmune, Inc; Human Genome Sciences, Inc; Idenix Pharmaceuticals; Johnson & Johnson/Tibotec; Pharmasset, Inc; Romark Laboratories; LC; Schering-Plough; Valeant; Wyeth; ZymoGenetics; Genentech Inc; Pfizer Inc; Rottapharm FX The authors disclose the following: Dr Reddy has served on ad hoc advisory committees for Roche, Merck & Co, Inc, Tibotec, Gilead Sciences, Inc, Vertex Pharmaceuticals, and Salix Pharmaceuticals and has received research grant support from Roche, Gilead Sciences, Inc, Tibotec, Bristol-Myers Squibb, Vertex Pharmaceuticals, Merck & Co, Inc, Boehringer Ingelheim, and Exalenz. Dr Shiffman has served on advisory committees or review panels for Anadys Pharmaceuticals Inc, Bayer, Biolex, Bristol-Myers Squibb, Celera Diagnostics, LLC, Conatus Pharmaceuticals, Echosense, Exalenz, Gilead Sciences, Inc, Human Genome Sciences, Inc, Merck & Co, Inc, Schering-Plough, Pfizer Inc, Roche, Romark Laboratories, LC, Salix Pharmaceuticals, Valeant, Vertex Pharmaceuticals, and ZymoGenetics; has served as a consultant for Celera Diagnostics, LLC, Conatus Pharmaceuticals, Exalenz, Human Genome Sciences, Inc, Pfizer Inc, and Roche; has received research grant support from Biolex, Celera Diagnostics, LLC, Conatus Pharmaceuticals, Exalenz, Gilead Sciences Inc, GlaxoSmithKline, GlobeImmune, Inc, Human Genome Sciences, Inc, Idenix Pharmaceuticals, Johnson & Johnson/Tibotec, Pharmasset, Inc, Roche, Romark Laboratories, LC, Schering-Plough, Valeant, Vertex Pharmaceuticals, Wyeth, and ZymoGenetics; has served on the speaker's bureau for Bayer, Bristol-Myers Squibb, Gilead Sciences, Inc, Roche, and Schering-Plough; has served on the data monitoring board for Abbott Laboratories and Anadys Pharmaceuticals Inc; and holds stock options for Exalenz. Dr Rodriguez-Torres has served as a consultant for Genentech Inc/Hoffmann-La Roche Ltd. Dr Cheinquer has received research grants from Roche and Bristol-Myers Squibb and has served as a consultant for Roche and Bristol-Myers Squibb. Dr Harrison has served on advisory and ad hoc committees for Three Rivers Pharmaceuticals and Amylin Pharmaceuticals, has served on the speaker's bureau for Salix Pharmaceuticals and Bristol-Myers Squibb, and has received grant support from Genentech Inc, Merck & Co, Inc, Pfizer Inc, and Rottapharm. The remaining authors disclose no conflicts. NR 26 TC 23 Z9 26 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 2010 VL 139 IS 6 BP 1972 EP 1983 DI 10.1053/j.gastro.2010.08.051 PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 688IS UT WOS:000284843600036 PM 20816836 ER PT J AU Styrsky, JN Guyer, C Balbach, H Turkmen, A AF Styrsky, Jennifer Nesbitt Guyer, Craig Balbach, Harold Turkmen, Asuman TI THE RELATIONSHIP BETWEEN BURROW ABUNDANCE AND AREA AS A PREDICTOR OF GOPHER TORTOISE POPULATION SIZE SO HERPETOLOGICA LA English DT Article DE Gopher tortoise; Gopherus polyphemus; Population size; Reserve area; Segmented regression ID HOME RANGE; POLYPHEMUS; MOVEMENT; PATTERNS; HABITAT AB Because gopher tortoises (Gopherus polyphemus) occupy high-value lands in the southeastern United States, are declining throughout their range, and stir public passion when they are entombed through currently legal take, refined conservation measures for this species are needed. Of particular interest is a determination of how many individuals constitute a population and what sized areas are required by such populations so that animals currently in harm's way might be moved to designated reserve areas. We use surveys of burrows of gopher tortoises from a large sample of areas of differing sizes to test for a relaxation of the linear relationship between area and number of burrows expected at the edge of a population of gopher tortoises. For measures of burrow abundance, some of our data are from sites on which estimates were based on transect samples; on other sites, complete counts were made. The relationship between area and abundance was elevated for transect samples compared to similar data from complete counts, indicating that transect data yield inflated counts when extrapolated over large areas. For complete counts, our data indicate a threshold point at which a linear relationship between area and abundance ends and a loss of this relationship for larger areas begins. This threshold point suggests that, on average, populations of gopher tortoises consist of 444 burrows, cover 755 ha, and contain 240 tortoises. These figures describe features of tortoises inhabiting a variety of lands that differ in current management goals and past land-use history,. Our results suggest that many current reserve areas for gopher tortoises are likely, to be too small. Our results also provide an example of how key conservation variables can be generated for long-lived species. C1 [Styrsky, Jennifer Nesbitt; Guyer, Craig] Auburn Univ, Dept Biol Sci, Auburn, AL 36849 USA. [Balbach, Harold] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Turkmen, Asuman] Auburn Univ, Dept Math & Stat, Auburn, AL 36849 USA. RP Guyer, C (reprint author), Auburn Univ, Dept Biol Sci, Auburn, AL 36849 USA. EM guyercr@auburn.edu NR 32 TC 5 Z9 5 U1 5 U2 27 PU HERPETOLOGISTS LEAGUE PI EMPORIA PA EMPORIA STATE UNIV, DIVISION BIOLOGICAL SCIENCES, 1200 COMMERCIAL ST, EMPORIA, KS 66801-5087 USA SN 0018-0831 J9 HERPETOLOGICA JI Herpetologica PD DEC PY 2010 VL 66 IS 4 BP 403 EP 410 DI 10.1655/09-021.1 PG 8 WC Zoology SC Zoology GA 698CJ UT WOS:000285568800003 ER PT J AU Harless, ML Walde, AD Delaney, DK Pater, LL Hayes, WK AF Harless, Meagan L. Walde, Andrew D. Delaney, David K. Pater, Larry L. Hayes, William K. TI SAMPLING CONSIDERATIONS FOR IMPROVING HOME RANGE ESTIMATES OF DESERT TORTOISES: EFFECTS OF ESTIMATOR, SAMPLING REGIME, AND SEX SO HERPETOLOGICAL CONSERVATION AND BIOLOGY LA English DT Article DE Desert Tortoise; Gopherus agassizii; home range; Mojave Desert; radio-telemetry; sampling ID KERNEL DENSITY ESTIMATORS; MONTE-CARLO SIMULATION; GOPHERUS-AGASSIZII; MOVEMENT PATTERNS; HABITAT USE; BODY-SIZE; AUTOCORRELATION AB Home range estimation as a measure of spatial utilization is an important tool in the management of wildlife. Operational methods of defining the spatial requirements of an animal differ in sampling regime and interpretation. The two most commonly used estimators, the minimum convex polygon (MCP) and the fixed kernel (FK), each provide a different measure of land use, yet, together allow for a better understanding of the spatial needs of a particular animal. Sampling frequency, the number of individuals, and other user-defined inputs differentially affect home range estimates using these two procedures. For the comparison of either MCP or FK estimates to be reliable, these variables need to be as similar as possible across studies. We conducted an intensive radio-telemetry study on a large number of Desert Tortoises (Gopherus agassizii) to determine an optimal sampling effort for home range estimation using both the MCP and FK estimates, and to identify factors important to space use by this species. Data were parsed into sampling regimes representative of previous home range studies in an effort to compare estimates across studies. Home range estimates using the MCP were over two times larger in this study when compared to previous studies on the Desert Tortoise in the Mojave Desert. Results indicated that an increased sampling frequency inflates MCP estimates, while providing more use-specific detail and decreasing area for FK estimates. Analyses demonstrated home range area to be greatly affected by choice of estimator (MCP or FK), sampling regime, and sex. We recommend an intensive and systematic sampling effort to better define home range estimates; as well as, to provide comparable data across studies for this and other species of herpetofauna. Both home range estimators provide valuable information on the biological needs of the Desert Tortoise and should be identified as a priority in land use investigations and conservation decisions for this species. C1 [Harless, Meagan L.; Walde, Andrew D.] ITS Corp, Atascadero, CA 93422 USA. [Harless, Meagan L.; Hayes, William K.] Loma Linda Univ, Dept Earth & Biol Sci, Loma Linda, CA 92354 USA. [Delaney, David K.; Pater, Larry L.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Harless, ML (reprint author), ITS Corp, 8000 San Gregorio Rd, Atascadero, CA 93422 USA. EM awalde@hotmail.com RI Hayes, William/L-1284-2013 OI Hayes, William/0000-0002-0903-0519 FU Construction Engineering Research Laboratory (USACERL), U.S. Army Engineer Research and Development Center (ERDC); ITS Corporation; contracting agency for USACERL; Directorate of Public Works at Fort Irwin National Training Center FX Field work would not have been completed without the coordinated efforts of the following individuals: Jill Adams, Nick Bieser, Leslie Bol, Brett DeGregorio, Kate Howard, Chris Howey, Miki Kern, Courtney LaMere, Erica Lee, Philippe Rosenfeld, Joel Strong, and Angela Walde. We thank Steve Dunbar for providing comments on early drafts of the manuscript. Research was conducted under United States Fish and Wildlife Service (USFWS) recovery permit TE066452-1 (to DKD and ADW) and California Department of Fish and Game (CDFG) Memorandum of Understanding for Scientific Collecting Permit # 802005-03 (to DKD and ADW). The Construction Engineering Research Laboratory (USACERL), which is an element of the U.S. Army Engineer Research and Development Center (ERDC), was the primary funding agency for this research. ITS Corporation, the contracting agency for USACERL, and the Directorate of Public Works at Fort Irwin National Training Center provided additional funding. NR 59 TC 15 Z9 15 U1 1 U2 23 PU HERPETOLOGICAL CONSERVATION & BIOLOGY PI CORVALLIS PA C/O R BRUCE BURY, USGS FOREST & RANGELAND, CORVALLIS, OR 00000 USA SN 1931-7603 J9 HERPETOL CONSERV BIO JI Herpetol. Conserv. Biol. PD DEC PY 2010 VL 5 IS 3 BP 374 EP 387 PG 14 WC Zoology SC Zoology GA 749ZL UT WOS:000289512000002 ER PT J AU Garfinkel, SL Parker-Wood, A Huynh, D Migletz, J AF Garfinkel, Simson L. Parker-Wood, Aleatha Huynh, Daniel Migletz, James TI An Automated Solution to the Multiuser Carved Data Ascription Problem SO IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY LA English DT Article DE Data mining; forensics; information security ID DISPUTED FEDERALIST-PAPERS; AUTHORSHIP AB This paper presents a novel solution to the problem of determining the ownership of carved information found on disk drives and other storage media that have been used by more than one person. When a computer is subject to forensic examination, information may be found that cannot be readily ascribed to a specific user. Such information is typically not located in a specific file or directory, but is found through file carving, which recovers data from unallocated disk sectors. Because the data is carved, it does not have associated file system metadata, and its owner cannot be readily ascertained. The technique presented in this paper starts by automatically recovering both file system metadata as well as extended metadata embedded in files (for instance, embedded timestamps) directly from a disk image. This metadata is then used to find exemplars and to create a machine learning classifier that can be used to ascertain the likely owner of the carved data. The resulting classifier is well suited for use in a legal setting since the accuracy can be easily verified using cross-validation. Our technique also results in a classifier that is easily validated by manual inspection. We report results of the technique applied to both specific hard drive data created in our laboratory and multiuser drives that we acquired on the secondary market. We also present a tool set that automatically creates the classifier and performs validation. C1 [Garfinkel, Simson L.] USN, Postgrad Sch, Dept Comp Sci, Pacific Grove, CA 93950 USA. [Parker-Wood, Aleatha] Univ Calif Santa Cruz, Dept Comp Sci, Santa Cruz, CA 95060 USA. [Huynh, Daniel] US Mil Acad, Dept Comp Sci, West Point, NY 10096 USA. [Migletz, James] US Marine Corps, Quantico, VA 22134 USA. RP Garfinkel, SL (reprint author), USN, Postgrad Sch, Dept Comp Sci, Pacific Grove, CA 93950 USA. EM simsong@acm.org NR 18 TC 4 Z9 4 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1556-6013 J9 IEEE T INF FOREN SEC JI IEEE Trans. Inf. Forensic Secur. PD DEC PY 2010 VL 5 IS 4 BP 868 EP 882 DI 10.1109/TIFS.2010.2060484 PG 15 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 681YG UT WOS:000284360000024 ER PT J AU Liu, N Xu, ZY Sadler, BM AF Liu, Ning Xu, Zhengyuan Sadler, Brian M. TI Ziv-Zakai Time-Delay Estimation Bounds for Frequency-Hopping Waveforms Under Frequency-Selective Fading SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Frequency diversity; frequency hopping; frequency-selective fading; time-delay estimation; Ziv-Zakai bound ID SIGNAL PARAMETER-ESTIMATION; CONVOLUTIVE RANDOM CHANNELS AB Ziv-Zakai Bayesian lower bounds on time-delay estimation (TDE) are developed for frequency hopping waveforms. These wideband waveforms are readily employed for both communications and TDE. We consider random frequency-selective fading channels, described by a Gaussian tapped delay line model with inter-hop correlation. The receiver does not know the channel realization to assist in estimating the time delay but does know the channel statistics. The development incorporates a random uniform prior on the delay. The bounds provide tight mean-square error prediction for the maximum a posteriori (MAP) estimator performance over a large range of signal-to-noise ratios (SNRs). They also accurately predict the TDE frequency diversity gain from multi-frequency transmission in fading channels. The special case of independent fading is discussed, including both flat Rician and Rayleigh fading, and closed-form expressions enable easy study of the effects of SNR, frequency diversity, and channel statistics on TDE. C1 [Liu, Ning; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Liu, N (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; bsadler@arl.army.mil FU Army Research Laboratory CTA on Communications and Networks [DAAD19-01-2-0011] FX Manuscript received December 04, 2009; accepted August 12, 2010. Date of publication August 19, 2010; date of current version November 17, 2010. The associate editor coordinating the review of this manuscript and approving it for publication was Prof. Peter Schreier. This work was supported in part by the Army Research Laboratory CTA on Communications and Networks under Grant DAAD19-01-2-0011. NR 18 TC 4 Z9 4 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD DEC PY 2010 VL 58 IS 12 BP 6400 EP 6406 DI 10.1109/TSP.2010.2068547 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 681YX UT WOS:000284361700033 ER PT J AU Dong, J Zaghloul, AI Rotman, R AF Dong, J. Zaghloul, A. I. Rotman, R. TI Phase-error performance of multi-focal and non-focal two-dimensional Rotman lens designs SO IET MICROWAVES ANTENNAS & PROPAGATION LA English DT Article ID RUZE AB The phase errors of the conventional trifocal Rotman lens and its modified quadrufocal designs could be reduced by adopting a non-focal design scheme. The non-focal design produces minimum average phase errors for all beam ports rather than achieving zero-phase error for only selected focal points. Fundamental models of designing and optimising typical trifocal and quadrufocal planar bootlace lenses are reviewed. Results based on the non-focal design method are compared to the ones from conventional designs, and noticeable improvements demonstrate that the non-focal design scheme is an alternative way of optimising the phase errors for the Rotman lens design. As in referenced papers on multiple-focal designs, the emphasis is on the phase-error analysis and not on experimental verifications. C1 [Dong, J.; Zaghloul, A. I.] Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. [Zaghloul, A. I.] USA, Res Lab, Adelphi, MD 20783 USA. [Rotman, R.] IAI Elta Elect Ind, Ashdod, Israel. RP Dong, J (reprint author), Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. EM junweid@gmail.com NR 21 TC 9 Z9 9 U1 0 U2 2 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8725 J9 IET MICROW ANTENNA P JI IET Microw. Antennas Propag. PD DEC PY 2010 VL 4 IS 12 BP 2097 EP 2103 DI 10.1049/iet-map.2009.0565 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 692FR UT WOS:000285139200014 ER PT J AU Howell, R Weerasooriya, T Van Aken, D AF Howell, R. Weerasooriya, T. Van Aken, D. TI TENSILE, HIGH STRAIN RATE COMPRESSION AND MICROSTRUCTURAL EVALUATION OF LIGHTWEIGHT AGE HARDENABLE CAST FE-30MN-9AL-XSI-0.9C-0.5MO STEEL SO INTERNATIONAL JOURNAL OF METALCASTING LA English DT Article DE tensile; strain rate compression; age hardened steel; shear ID AL-C ALLOYS; PHASE-TRANSFORMATIONS; MECHANICAL-PROPERTIES; AUSTENITIC STEELS; SI AB Age hardenable, castable, and lightweight Fe-Mn-Al-C steels are currently being developed and evaluated for substitution of high strength low alloy steel and to meet MIL-PRF-32269 criteria. Two nominal Fe-30Mn-9Al-0.9C-0.5Mo steels were cast and modified with 1 and 1.4 wt.% silicon. Ageing, tensile, and high strain rate compression testing were performed on solution treated and aged samples of both chemistries. Each alloy was solution treated at 1050 degrees C for 2 hours. Microstructures of the solution treated and aged alloys show primary austenite with less than 8 volume % ferrite. The solution treated hardness of the low silicon steel was 230 BHN and the high silicon alloy was 225 BHN. Specimens were aged at 530 degrees C for up to 60 hours. Peak ageing occurs after 30 hours with a peak hardness of 371 BHN for the 1% silicon containing alloy and 377 BHN for the high silicon alloy. Tensile strengths of the 30 hour aged specimens were 1065 MPa (154 ksi) and 1080 MPa (156 ksi)for the low and high silicon alloys. High strain rate compression testing was conducted on solution treated and 10 hour aged 1% Si containing alloy. Compressive strength of the I wt.% Si alloy exceeded 1,500 MPa (217 ksi) at a strain rate of 3000 s.(-1). C1 [Howell, R.; Weerasooriya, T.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Van Aken, D.] Missouri Univ Sci & Technol, Rolla, MO USA. RP Howell, R (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 26 TC 1 Z9 1 U1 3 U2 7 PU AMER FOUNDRY SOC INC PI SCHAUMBURG PA 1695 N PENNY LN, SCHAUMBURG, IL 60173-4555 USA SN 1939-5981 J9 INT J METALCA ST JI Int. J. Met. PD WIN PY 2010 VL 4 IS 1 BP 7 EP 18 PG 12 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA 541VO UT WOS:000273449300002 ER PT J AU Natesan, M Ulrich, RG AF Natesan, Mohan Ulrich, Robert G. TI Protein Microarrays and Biomarkers of Infectious Disease SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE protein microarray; infectious diseases; biomarkers ID ROLLING-CIRCLE AMPLIFICATION; DIAGNOSTIC ANTIGEN DISCOVERY; VIRUS IMMUNOLOGICAL STATUS; HUMORAL IMMUNE-RESPONSE; ANTIBODY MICROARRAYS; FRANCISELLA-TULARENSIS; ARRAYS; IDENTIFICATION; CANCER; PROTEOMICS AB Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. Depending on the application, design issues should be considered, such as the need for multiplexing and label or label free detection methods. New developments, challenges, and future demands in infectious disease research will impact the application of protein microarrays for discovery and validation of biomarkers. C1 [Natesan, Mohan; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA. RP Natesan, M (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA. EM mohan.natesan@us.army.mil; rulrich@bioanalysis.org NR 90 TC 12 Z9 12 U1 2 U2 12 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1422-0067 J9 INT J MOL SCI JI Int. J. Mol. Sci. PD DEC PY 2010 VL 11 IS 12 BP 5166 EP 5184 DI 10.3390/ijms11125165 PG 19 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary SC Biochemistry & Molecular Biology; Chemistry GA 700BV UT WOS:000285708000028 PM 21614200 ER PT J AU Katayama, T Kato, T Tanaka, M Douglas, TA Brouchkoy, A Abe, A Sone, T Fukuda, M Asano, K AF Katayama, Taiki Kato, Tomoko Tanaka, Michiko Douglas, Thomas A. Brouchkoy, Anatoli Abe, Ayumi Sone, Teruo Fukuda, Masami Asano, Kozo TI Tomitella biformata gen. nov., sp nov., a new member of the suborder Corynebacterineae isolated from a permafrost ice wedge SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID BACTERIA; CHROMATOGRAPHY; ACIDS AB Gram-reaction-positive, aerobic, non-spore-forming, irregular rod-shaped bacteria, designated AHU1821(T) and AHU1820, were isolated from an ice wedge in the Fox permafrost tunnel, Alaska. The strains were psychrophilic, growing at 5 to 27 degrees C. Phylogenetic analysis of the 16S rRNA and gyrB gene sequences indicated that the ice-wedge isolates formed a clade distinct from other mycolic-acid-containing bacteria within the suborder Corynebacterineae. The cell wall of strains AHU1821(T) and AHU1820 contained meso-diaminopimelic acid, arabinose and galactose, indicating chemotype IV. The muramic acids in the peptidoglycan were glycolated. The predominant menaquinone was MK-9(H(2)). The polar lipids consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylinositol mannosides and an unidentified glycolipid. The major fatty acids were hexadecenoic acid (C(16:1)), hexadecanoic acid (C(16:0)), octadecenoic acid (C(18:1)) and tetradecanoic acid (C(14:0)). Tuberculostearic acid was present in relatively small amounts (1%). Strains AHU1821(T) and AHU1820 contained mycolic acids with 42-52 carbons. The DNA G+C content of the two strains was 69.3-71.6 mol% (T(m)). 16S rRNA, rpoB and recA gene sequences were identical between strains AHU1821(T) and AHU1820 and those of the gyrB gene showed 99.9% similarity. Based on phylogenetic and phenotypic evidence, strains AHU1821(T) and AHU1820 represent a single novel species of a novel genus, for which the name Tomitella biformata gen. nov., sp. nov. is proposed. The type strain of Tomitella biformata is AHU1821(T) (=DSM 45403(T) =NBRC 106253(T)). C1 [Katayama, Taiki; Kato, Tomoko; Tanaka, Michiko; Abe, Ayumi; Sone, Teruo; Asano, Kozo] Hokkaido Univ, Grad Sch Agr, Lab Appl Microbiol, Kita Ku, Sapporo, Hokkaido 0608589, Japan. [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Brouchkoy, Anatoli] Tyumen State Oil & Gas Univ, Russian Acad Sci, Siberian Branch, Tyumen Sci Ctr, Tyumen 625048, Russia. [Fukuda, Masami] Univ Alaska, Int Arct Res Ctr, Fairbanks, AK 99775 USA. RP Asano, K (reprint author), Hokkaido Univ, Grad Sch Agr, Lab Appl Microbiol, Kita Ku, N9 W9, Sapporo, Hokkaido 0608589, Japan. EM asanok@chem.agr.hokudai.ac.jp RI Sone, Teruo/A-4269-2012; Tanaka, Michiko/F-5790-2012; ASANO, Kozo/F-6927-2012 FU Institute for Fermentation, Osaka (IFO) FX We are grateful to Dr Daiichi Honjo for help with the nomenclature and to Dr Masanori Yasui for technical assistance with the scanning microscopic observations. This study was supported in part by a grant from the Institute for Fermentation, Osaka (IFO). NR 14 TC 7 Z9 8 U1 1 U2 7 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD DEC PY 2010 VL 60 BP 2803 EP 2807 DI 10.1099/ijs.0.017962-0 PN 12 PG 5 WC Microbiology SC Microbiology GA 705VP UT WOS:000286169100020 PM 20081023 ER PT J AU Brassell, SA AF Brassell, Stephen A. TI Editorial Comment to Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients SO INTERNATIONAL JOURNAL OF UROLOGY LA English DT Editorial Material C1 [Brassell, Stephen A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Brassell, Stephen A.] Ctr Prostate Dis Res, Washington, DC USA. [Brassell, Stephen A.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM stephen.brassell@amedd.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0919-8172 J9 INT J UROL JI Int. J. Urol. PD DEC PY 2010 VL 17 IS 12 BP 988 EP 988 DI 10.1111/j.1442-2042.2010.02654.x PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 684IR UT WOS:000284544100004 PM 21091794 ER PT J AU McDonald, RMS AF McDonald, Robert M. S. TI West Pointers and the Civil War: The Old Army in War and Peace SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [McDonald, Robert M. S.] US Mil Acad, West Point, NY 10996 USA. RP McDonald, RMS (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2010 VL 97 IS 3 BP 810 EP 810 PG 1 WC History SC History GA 699KR UT WOS:000285662800061 ER PT J AU Chen, L Zhang, J Hu, XJ Philipson, KD Scharf, SM AF Chen, Ling Zhang, Jin Hu, Xuejiao Philipson, Kenneth D. Scharf, Steven M. TI The Na+/Ca2+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE sleep apnea; hypertension; hypertrophy; heart failure; apoptosis ID CARDIOVASCULAR-DISEASE; NA+-CA2+ EXCHANGER; BLOOD-PRESSURE; SLEEP-APNEA; SARCOPLASMIC-RETICULUM; GENOMIC CONSEQUENCES; VASCULAR REACTIVITY; CARDIAC MYOCYTES; OXIDATIVE STRESS; HEART-FAILURE AB Chronic intermittent hypoxia (CIH) and cardiovascular dysfunction occur in patients with obstructive sleep apnea. We hypothesized that the Na+/Ca2+ exchanger-1 (NCX1) mediates, at least partially, left ventricular (LV) dysfunction in CIH. Four groups of mice (N = 15-17 per group), either cardiac-specific NCX1 knockouts (KO) or wild types (WT), were exposed to either CIH or normoxia [i.e., handled controls (HC)] 10 h/day for 8 wk. As expected, myocardial expression of NCX1 was greater in WT than in KO animals, both in HC and CIH-exposed groups. In both CIH groups (WT or KO), but not the HC groups, blood pressure increased by 10% at week 1 over their baseline and remained elevated for all 8 wk, with no differences between WT and KO. LV dilation (increased diastolic and systolic dimension) and hypertrophy (increased left heart weight), along with LV dysfunction (greater end-diastolic pressure and lower ejection fraction), were observed in the WT animals compared with the KO following CIH exposure. Compared with HC, CIH exposure was associated with apoptosis (terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling and caspase-3) in WT, but not KO, mice. We conclude that myocardial NCX1 does not mediate changes in blood pressure, but is one of the mediators for LV global dysfunction and cardiomyocyte injury in CIH. C1 [Chen, Ling; Scharf, Steven M.] Univ Maryland, Dept Med, Baltimore, MD 21201 USA. [Chen, Ling; Zhang, Jin] Univ Maryland, Dept Physiol, Baltimore, MD 21201 USA. [Hu, Xuejiao] Womack Army Med Ctr, Dept Pathol, Ft Bragg, NC USA. [Philipson, Kenneth D.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA. RP Chen, L (reprint author), 685 W Baltimore St,MSTF 816, Baltimore, MD 21201 USA. EM Lchen@medicine.umaryland.edu FU Mid-Atlantic American Heart Association [0765262U]; National Heart, Lung, and Blood Institute [HL074441] FX This study was supported by a grant-in-aid from the Mid-Atlantic American Heart Association (0765262U, L. Chen). S. M. Scharf was supported by National Heart, Lung, and Blood Institute Grant HL074441. NR 38 TC 17 Z9 19 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2010 VL 109 IS 6 BP 1675 EP 1685 DI 10.1152/japplphysiol.01372.2009 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 695FK UT WOS:000285355800015 PM 20947716 ER PT J AU Castellani, JW Muza, SR Cheuvront, SN Sils, IV Fulco, CS Kenefick, RW Beidleman, BA Sawka, MN AF Castellani, John W. Muza, Stephen R. Cheuvront, Samuel N. Sils, Ingrid V. Fulco, Charles S. Kenefick, Robert W. Beidleman, Beth A. Sawka, Michael N. TI Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sickness SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE dehydration; hypobaria; hypoxia; time trial ID BRAIN-BARRIER FUNCTION; PHYSIOLOGICAL-RESPONSES; DEHYDRATION; BLOOD; HYDRATION; HYPOXIA; PLASMA; VOLUME AB Castellani JW, Muza SR, Cheuvront SN, Sils IV, Fulco CS, Kenefick RW, Beidleman BA, Sawka MN. Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sickness. J Appl Physiol 109: 1792-1800, 2010. First published September 23, 2010; doi: 10.1152/japplphysiol.00517.2010.-Hypoxia often causes body water deficits (hypohydration, HYPO); however, the effects of HYPO on aerobic exercise performance and prevalence of acute mountain sickness (AMS) at high altitude (ALT) have not been reported. We hypothesized that 1) HYPO and ALT would each degrade aerobic performance relative to sea level (SL)-euhydrated (EUH) conditions, and combining HYPO and ALT would further degrade performance more than one stressor alone; and 2) HYPO would increase the prevalence and severity of AMS symptoms. Seven lowlander men (25 +/- 7 yr old; 82 +/- 11 kg; mean +/- SD) completed four separate experimental trials. Trials were 1) SL-EUH, 2) SL-HYPO, 3) ALT-EUH, and 4) ALT-HYPO. In HYPO, subjects were dehydrated by 4% of body mass. Subjects maintained hydration status overnight and the following morning entered a hypobaric chamber (at SL or 3,048 m, 27 C) where they completed 30 min of submaximal exercise immediately followed by a 30-min performance time trial (TT). AMS was measured with the Environmental Symptoms Questionnaire-Cerebral Score (AMS-C) and the Lake Louise Scoring System (LLS). The percent change in TT performance, relative to SL-EUH, was -19 +/- 12% (334 +/- 64 to 278 +/- 87 kJ), -11 +/- 10% (334 +/- 64 to 293 +/- 33 kJ), and -34 +/- 22% (334 +/- 64 to 227 +/- 95 kJ), for SL-HYPO, ALT-EUH, and ALT-HYPO, respectively. AMS symptom prevalence was 2/7 subjects at ALT-EUH for AMS-C and LLS and 5/7 and 4/7 at ALT-HYPO for AMS-C and LLS, respectively. The AMS-C symptom severity score (AMS-C score) tended to increase from ALT-EUH to ALT-HYPO but was not significant (P = 0.07). In conclusion, hypohydration at 3,048 m 1) degrades aerobic performance in an additive manner with that induced by ALT; and 2) did not appear to increase the prevalence/severity of AMS symptoms. C1 [Castellani, John W.; Muza, Stephen R.; Cheuvront, Samuel N.; Sils, Ingrid V.; Fulco, Charles S.; Kenefick, Robert W.; Beidleman, Beth A.; Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Castellani, JW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. EM john.castellani@us.army.mil NR 38 TC 24 Z9 24 U1 0 U2 8 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2010 VL 109 IS 6 BP 1792 EP 1800 DI 10.1152/japplphysiol.00517.2010 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 695FK UT WOS:000285355800030 PM 20864559 ER PT J AU Leon, LR Helwig, BG AF Leon, Lisa R. Helwig, Bryan G. TI Heat stroke: Role of the systemic inflammatory response SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Review DE exertional heat stroke; heat stress; hyperthermia; cytokines; systemic inflammatory response syndrome ID ACTIVATED PROTEIN-C; DISSEMINATED INTRAVASCULAR COAGULATION; TUMOR-NECROSIS-FACTOR; EXERTIONAL HEATSTROKE; LIVER-FAILURE; SEVERE SEPSIS; STRESS; MICE; WAVE; CYTOKINES AB Heat stroke is a life-threatening illness that is characterized clinically by central nervous system dysfunction, including delirium, seizures, or coma and severe hyperthermia. Rapid cooling and support of multi-organ function are the most effective clinical treatments, but many patients experience permanent neurological impairments or death despite these efforts. The highest incidence of heat stroke deaths occurs in very young or elderly individuals during summer heat waves, with similar to 200 deaths per year in the United States. Young, fit individuals may experience exertional heat stroke while performing strenuous physical activity in temperate or hot climates. Factors that predispose to heat stroke collapse include pre-existing illness, cardiovascular disease, drug use, and poor fitness level. For decades the magnitude of the hyperthermic response in heat stroke patients was considered the primary determinant of morbidity and mortality. However, recent clinical and experimental evidence suggests a complex interplay between heat cytotoxicity, coagulation, and the systemic inflammatory response syndrome (SIRS) that ensues following damage to the gut and other organs. Cytokines are immune modulators that have been implicated as adverse mediators of the SIRS, but recent data suggest a protective role for these proteins in the resolution of inflammation. Multi-organ system failure is the ultimate cause of mortality, and recent experimental data indicate that current clinical markers of heat stroke recovery may not adequately reflect heat stroke recovery in all cases. Currently heat stroke is a more preventable than treatable condition, and novel therapeutics are required to improve patient outcome. C1 [Leon, Lisa R.; Helwig, Bryan G.] USA, Environm Med Res Inst, Thermal Mt Med Div, Natick, MA 01760 USA. RP Leon, LR (reprint author), USA, Environm Med Res Inst, Thermal Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon@us.army.mil NR 90 TC 108 Z9 136 U1 3 U2 30 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2010 VL 109 IS 6 BP 1980 EP 1988 DI 10.1152/japplphysiol.00301.2010 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 695FK UT WOS:000285355800051 PM 20522730 ER PT J AU Cheuvront, SN Kenefick, RW Montain, SJ Sawka, MN AF Cheuvront, Samuel N. Kenefick, Robert W. Montain, Scott J. Sawka, Michael N. TI Mechanisms of aerobic performance impairment with heat stress and dehydration SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Review DE hypohydration; fluid balance; environment; critical core temperature; fatigue ID MUSCLE BLOOD-FLOW; MAXIMAL OXYGEN-UPTAKE; PROLONGED EXERCISE; SKIN TEMPERATURE; SKELETAL-MUSCLE; PERCEIVED EXERTION; CORE TEMPERATURE; THERMOREGULATORY RESPONSES; PHYSIOLOGICAL TOLERANCE; ISOMETRIC CONTRACTIONS AB Environmental heat stress can challenge the limits of human cardiovascular and temperature regulation, body fluid balance, and thus aerobic performance. This minireview proposes that the cardiovascular adjustments accompanying high skin temperatures (T(sk)), alone or in combination with high core body temperatures (T(c)), provide a primary explanation for impaired aerobic exercise performance in warm-hot environments. The independent (T(sk)) and combined (T(sk) + T(c)) effects of hyperthermia reduce maximal oxygen uptake ((V) over dotO(2max)), which leads to higher relative exercise intensity and an exponential decline in aerobic performance at any given exercise workload. Greater relative exercise intensity increases cardiovascular strain, which is a prominent mediator of rated perceived exertion. As a consequence, incremental or constant-rate exercise is more difficult to sustain (earlier fatigue) or requires a slowing of self-paced exercise to achieve a similar sensation of effort. It is proposed that high T(sk) and T(c) impair aerobic performance in tandem primarily through elevated cardiovascular strain, rather than a deterioration in central nervous system (CNS) function or skeletal muscle metabolism. Evaporative sweating is the principal means of heat loss in warm-hot environments where sweat losses frequently exceed fluid intakes. When dehydration exceeds 3% of total body water (2% of body mass) then aerobic performance is consistently impaired independent and additive to heat stress. Dehydration augments hyperthermia and plasma volume reductions, which combine to accentuate cardiovascular strain and reduce (V)O(2max). Importantly, the negative performance consequences of dehydration worsen as T(sk) increases. C1 [Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil NR 100 TC 122 Z9 124 U1 5 U2 56 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2010 VL 109 IS 6 BP 1989 EP 1995 DI 10.1152/japplphysiol.00367.2010 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 695FK UT WOS:000285355800052 PM 20689090 ER PT J AU Tintle, SM Keeling, JJ Shawen, SB Forsberg, JA Potter, BK AF Tintle, Scott M. Keeling, John J. Shawen, Scott B. Forsberg, Jonathan A. Potter, Benjamin K. TI Traumatic and Trauma-Related Amputations Part I General Principles and Lower-Extremity Amputations SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Review ID PRESSURE PULSATILE LAVAGE; BELOW-KNEE AMPUTATION; LOWER-LIMB AMPUTATIONS; QUALITY-OF-LIFE; TRANS-TIBIAL AMPUTATION; LONG-TERM OUTCOMES; FOLLOW-UP; TRANSTIBIAL AMPUTATIONS; TRANSFEMORAL AMPUTATION; SYMES AMPUTATION C1 [Tintle, Scott M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. RP Tintle, SM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave N W,Bldg 2,Clin 5A, Washington, DC 20307 USA. OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 126 TC 26 Z9 26 U1 0 U2 9 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC 1 PY 2010 VL 92A IS 17 BP 2852 EP 2868 DI 10.2106/JBJS.J.00257 PG 17 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 691YK UT WOS:000285118500012 PM 21123616 ER PT J AU Colborn, JM Kosoy, MY Motin, VL Telepnev, MV Valbuena, G Myint, KS Fofanov, Y Putonti, C Feng, C Peruski, L AF Colborn, James M. Kosoy, Michael Y. Motin, Vladimir L. Telepnev, Maxim V. Valbuena, Gustavo Myint, Khin S. Fofanov, Yuri Putonti, Catherine Feng, Chen Peruski, Leonard TI Improved Detection of Bartonella DNA in Mammalian Hosts and Arthropod Vectors by Real-Time PCR Using the NADH Dehydrogenase Gamma Subunit (nuoG) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CAT-SCRATCH DISEASE; HENSELAE; TRANSMISSION; ENDOCARDITIS; ACQUISITION; INFECTIONS; HOMELESS; STRAINS; 16S-23S; WILD AB We used a whole-genome scanning technique to identify the NADH dehydrogenase gamma subunit (nuoG) primer set that is sensitive and specific enough to detect a diverse number of Bartonella species in a wide range of environmental samples yet maintains minimal cross-reactivity to mammalian host and arthropod vector organisms. C1 [Colborn, James M.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Motin, Vladimir L.; Valbuena, Gustavo] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA. [Motin, Vladimir L.; Telepnev, Maxim V.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX USA. [Myint, Khin S.; Feng, Chen] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Fofanov, Yuri; Putonti, Catherine] Univ Houston, Dept Comp Sci, Houston, TX 77204 USA. [Peruski, Leonard] Global Dis Detect Network, Int Emerging Infect Program, Nonthaburi, Thailand. RP Kosoy, MY (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. EM mck3@cdc.gov RI Motin, Vladimir/O-1535-2013 NR 24 TC 12 Z9 12 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 2010 VL 48 IS 12 BP 4630 EP 4633 DI 10.1128/JCM.00470-10 PG 4 WC Microbiology SC Microbiology GA 686JU UT WOS:000284693400051 PM 20926707 ER PT J AU Moscicki, EK West, JC Rae, DS Rubio-Stipec, M Wilk, JE Regier, DA AF Moscicki, Eve K. West, Joyce C. Rae, Donald S. Rubio-Stipec, Maritza Wilk, Joshua E. Regier, Darrel A. TI Suicidality Is Associated With Medication Access Problems in Publicly Insured Psychiatric Patients SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID BIPOLAR DISORDER; RISK-FACTORS; UNITED-STATES; PART D; MENTAL-DISORDERS; TREATMENT ADHERENCE; FOLLOW-UP; AXIS-I; SCHIZOPHRENIA; DISCONTINUATION AB Background: Beginning January I, 2006, the Medicare Part D prescription drug benefit shifted drug coverage from Medicaid to the new Medicare Part D program for patients who were eligible for both Medicare and Medicaid benefits ("dual-eligibles"). These patients were randomly assigned to a private Part D plan and came under specific formulary and utilization management procedures of the plan in which they were enrolled. Objective: To examine the relationship between physician-reported medication switches, discontinuations, and other access problems and suicidal ideation or behavior among "dual-eligible" psychiatric patients. Method: Data were collected in 3 cross-sectional cycles in 2006 (January-April, May-August, and September-December) as part of the National Study of Medicaid and Medicare Psychopharmacologic Treatment Access and Continuity using through-the-mail, practice-based survey research methods. Data from the third cycle, representing all events since January 1, 2006, were used for these analyses. A national sample of psychiatrists randomly selected from the AMA Masterfile provided clinically detailed data on 1 systematically selected, dual-eligible psychiatric patient (N = 908). Propensity score analyses adjusted for patient sociodemographics, treatment setting, diagnoses, and psychiatric symptom severity. Results: Patients who experienced medication switches, discontinuations, and other access problems had 3 times the rate of suicidal ideation or behavior compared with patients with no access problems (22.0% vs 7.4%, P<.0001). Mean odds ratios and excess probabilities were highest for patients who were clinically stable but were required to switch medications (31.8%; mean OR = 4.87, mean P = 8.92(-5), excess probability = 0.21). Patients who experienced discontinuations (26.4%; mean OR = 2.13, mean P = 2.12(-2), excess probability = 0.12), other access problems (18.7%; mean OR = 3.01, mean P = 1.03(-5), excess probability 0.15), and multiple access problems (22.3%; mean OR = 2.88, mean P 4.10(-5), excess probability = 0.14) also had significantly increased suicidal ideation or behavior. Conclusion: Increased occurrences of suicidal ideation or behavior appear to be associated with disruptions in patient medication access and continuity. Clinicians need to be aware of the possibility of increased suicidality when, for administrative reasons, a clinically stable patient's medication regimen is altered. Dual-eligible psychiatric patients represent a highly vulnerable group with a substantial burden of illness; these findings underscore the need to provide special protections for this population. J Clin Psychiatry 2010;71(12):1657-1663 (C) Copyright 2010 Physicians Postgraduate Press, Inc. C1 [Moscicki, Eve K.; West, Joyce C.; Rae, Donald S.; Rubio-Stipec, Maritza; Regier, Darrel A.] APIRE, Arlington, VA USA. [Wilk, Joshua E.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Moscicki, EK (reprint author), 1000 Wilson Blvd,Ste 1825, Arlington, VA 22209 USA. EM emoscicki@psych.org FU American Psychiatric Foundation; AstraZeneca; Bristol-Myers Squibb; Eli Lilly; Forest; Janssen; Pfizer; Wyeth FX This work was supported by an unrestricted grant from the American Psychiatric Foundation through a consortium of industry supporters, including AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Forest, Janssen, Pfizer, and Wyeth. The authors had complete discretion and control over the design and conduct of the study, data analyses, and interpretation and reporting of the findings. NR 60 TC 0 Z9 0 U1 2 U2 3 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 USA SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 2010 VL 71 IS 12 BP 1657 EP 1663 DI 10.4088/JCP.10m06177gre PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 707OO UT WOS:000286296100012 PM 21190639 ER PT J AU Xu, Y Zheng, ZC Wilson, DK AF Xu, Y. Zheng, Z. C. Wilson, D. K. TI SIMULATION OF TURBULENT WIND NOISE REDUCTION BY POROUS WINDSCREENS USING HIGH-ORDER SCHEMES SO JOURNAL OF COMPUTATIONAL ACOUSTICS LA English DT Article DE Wind noise; porous medium; high-order scheme; windscreen ID IMMERSED-BOUNDARY METHOD; FINITE-DIFFERENCE; FLOW; IMPLEMENTATION; FLUCTUATIONS; EQUATIONS; CYLINDER; SURFACES AB The purpose of the study is to investigate the wind noise reduction provided by microphone windscreens at different frequencies of the impinging turbulence. The windscreen is assumed to be a cylindrically shaped porous medium. This paper uses a high-order scheme to improve the accuracy at the interface between air and porous medium. The computational scheme is based on a modified immersed-boundary method with distributed forcing terms. The simulation results show that, for low-frequency turbulence, the windscreens with low flow resistivity are more effective in noise reduction, while for high-frequency turbulence, the windscreens with high flow resistivity are more effective. C1 [Xu, Y.] Chinese Acad Sci, Key Lab Micrograv, Inst Mech, Beijing 100190, Peoples R China. [Zheng, Z. C.] Univ Kansas, Dept Aerosp Engn, Lawrence, KS 66045 USA. [Wilson, D. K.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Xu, Y (reprint author), Chinese Acad Sci, Key Lab Micrograv, Inst Mech, Beijing 100190, Peoples R China. EM yingxu@imech.ac.cn; zzheng@ku.edu; D.Keith.Wilson@usace.army.mil RI Zheng, Z/E-8930-2011; Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU US Army Engineer Research and Development Center [W913E7-07-C-0004] FX This research was partially supported by the US Army Engineer Research and Development Center under contract W913E7-07-C-0004 when the first two authors were at Kansas State University. NR 17 TC 6 Z9 6 U1 2 U2 5 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-396X J9 J COMPUT ACOUST JI J. Comput. Acoust. PD DEC PY 2010 VL 18 IS 4 BP 321 EP 334 DI 10.1142/S0218396X10004231 PG 14 WC Acoustics; Mathematics, Interdisciplinary Applications SC Acoustics; Mathematics GA 700ZH UT WOS:000285783600002 ER PT J AU Koutchma, T Song, Y Setikaite, I Juliano, P Barbosa-Canovas, GV Dunne, CP Patazca, E AF Koutchma, Tatiana Song, Yoonseok Setikaite, Ilona Juliano, Pablo Barbosa-Canovas, Gustavo V. Dunne, C. Patrick Patazca, Eduardo TI PACKAGING EVALUATION FOR HIGH-PRESSURE HIGH-TEMPERATURE STERILIZATION OF SHELF-STABLE FOODS SO JOURNAL OF FOOD PROCESS ENGINEERING LA English DT Article ID BARRIER AB The integrity of flexible packages during high-pressure (HP) sterilization is of critical importance to the safety and shelf life of food products. For HP-sterilization, packaged products need to be preheated to a target temperature before HP processing. Preheating efficiency can be affected by the packaging material utilized. The objectives were to quantify the impact of packaging materials on the rate of heat penetration into foods during preheating, and to evaluate the effects of preheating and HP processing (at 688 MPa and 121C) on package integrity, oxygen permeability and mechanical properties for commercially available packaging materials. Commercial scrambled egg patties were vacuum-sealed in pouches. Four plastic-laminated materials (nylon/coextruded ethylene-vinyl alcohol, nylon/polypropylene [PP], polyethylene terephthalate [PET]/aluminum oxide/casted PP [CPP] and PET/polyethylene) and two aluminum foil-laminated pouches (PET/aluminum [Al]/CPP and nylon/Al/PP) were tested. Selected packaging materials also were evaluated after thermal retort (TR) treatment and HP low temperature processing. The results demonstrated that foil-laminated materials provided shorter preheating time than thinner polymeric materials. HP treatment at high temperatures (HP-HT) increased seal strength of foil-laminated pouches. However, the HP-HT process did not significantly contribute to changes in seal strength of plastic-laminated pouches. It was found that the HP-HT process altered the oxygen barrier of the composite packaging materials. However, the increase in permeability observed during the HP-HT process was attributed to thermal damage occurring during preheating. TR processing increased oxygen permeability to a higher extent than HP-HT processing. It was concluded that the selected packaging materials could provide the required oxygen barrier for HP-HT treated shelf-stable foods. C1 [Koutchma, Tatiana; Setikaite, Ilona; Patazca, Eduardo] IIT, Summit Argo, IL 60501 USA. [Song, Yoonseok] US FDA, Natl Ctr Food Safety & Technol, Summit Argo, IL 60501 USA. [Setikaite, Ilona] Quaker Tropicana Gatorade PepsiCo, Barrington, IL USA. [Juliano, Pablo; Barbosa-Canovas, Gustavo V.] Washington State Univ, Dept Biol Syst Engn, Pullman, WA 99164 USA. [Juliano, Pablo] Food Sci Australia, Innovat Foods Ctr, Werribee, Vic 3030, Australia. [Dunne, C. Patrick] USA, Res Dev & Engn Command, Natick, MA 01760 USA. RP Koutchma, T (reprint author), Agr & Agri Food Canada, 93 Stone Rd W, Guelph, ON N1G 5C9, Canada. EM koutchmat@agr.gc.ca RI Juliano, Pablo/H-9251-2013 OI Juliano, Pablo/0000-0002-7425-8085 NR 19 TC 14 Z9 15 U1 4 U2 26 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0145-8876 J9 J FOOD PROCESS ENG JI J. Food Process Eng. PD DEC PY 2010 VL 33 IS 6 BP 1097 EP 1114 DI 10.1111/j.1745-4530.2008.00328.x PG 18 WC Engineering, Chemical; Food Science & Technology SC Engineering; Food Science & Technology GA 689XH UT WOS:000284963700008 ER PT J AU Drake, ML Farber, GL White, KL Parks, BG Segalman, KA AF Drake, Matthew L. Farber, Gerald L. White, Kacey L. Parks, Brent G. Segalman, Keith A. TI Restoration of Longitudinal Forearm Stability Using a Suture Button Construct SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE Essex-Lopresti injury interosseous membrane; suture button ID INTEROSSEOUS MEMBRANE; RADIAL HEAD; RADIOULNAR DISSOCIATION; RECONSTRUCTION; LIGAMENT; CADAVERS; LOAD; REPLACEMENT; INJURIES AB Purpose This study proposed a method of restoring the longitudinal stability of the forearm provided by the central band of the interosseous membrane (TOM) by using a percutaneously placed suture button construct We hypothesized that supporting the forearm IOM with a suture button construct would restore longitudinal stability in a cadaveric model of the Essex-Lopresti lesion Methods We assessed 7 adult cadaver upper extremities radiographically for evidence of previous elbow, forearm, or wrist fracture Each limb was mounted onto a materials testing system with the elbow held at 90 degrees and the forearm in neutral The intact specimen was loaded cyclically at 134 N to determine the native mobility of the forearm segment Each specimen was tested after each of the following steps radial head removal, transection of the IOM, and suture button construct reconstruction of the IOM After the final reconstruction, each specimen was examined for forearm range of motion and evidence of neurovascular injury Results Removal of the radial head and sectioning of the IOM sequentially increased average proximal migration of the radius by 3 6 and 7 1 mm, respectively After reconstruction with the suture button construct, the TOM was restored to the intact state with only the radial head removed Forearm rotation was not compromised by the reconstruction, and there was no evidence of neurovascular injury in any specimen Conclusions A percutaneously placed suture button construct can restore the longitudinal stability provided by an TOM The method described did not limit forearm rotation We encountered no neurovascular injury in the specimens tested in this series This construct may be an effective adjunct when combined with bony reconstruction to treat longitudinal forearm axis injuries (J Hand Surg 2010,35A 1981-1985 Copyright (C) 2010 by the American Society for Surgery of the Hand All rights reserved) C1 Union Mem Hosp, Curtis Natl Hand Ctr, Baltimore, MD USA. Tripler Army Med Ctr, Kailua, HI USA. RP Segalman, KA (reprint author), Care of Mattson AR, 3333 N Calvert St,Suite M60, Baltimore, MD 21218 USA. FU Raymond M Curtis Research Foundation Curtis National Hand Center Baltimore MD FX Supported by a grant from the Raymond M Curtis Research Foundation Curtis National Hand Center Baltimore MD NR 15 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD DEC PY 2010 VL 35A IS 12 BP 1981 EP 1985 DI 10.1016/j.jhsa.2010.09.009 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 695LJ UT WOS:000285371300010 PM 21134612 ER PT J AU Arnas, AO Boettner, DD Tamm, G Norberg, SA Whipple, JR Benson, MJ VanPoppel, BP AF Arnas, A. Oezer Boettner, Daisie D. Tamm, Gunnar Norberg, Seth A. Whipple, Jason R. Benson, Michael J. VanPoppel, Bret P. TI On the Analysis of the Aerodynamic Heating Problem SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article DE aerodynamic heating; convection; flat plate ID FRICTION AB A complete analytical solution to the problem of aerodynamic heating is lacking in heat transfer textbooks, which are used for undergraduate and graduate education. There are many issues that are very important from a convective heat transfer point of view. In practice, poor analyses lead to poor design, thus faulty manufacturing. Since, over the years analysis has given way to numerical studies, the instructors do not take the necessary time to go through analytical details. Thus the students just use the results without any awareness of how to get them and the inherent limitations of the analytical solution. The only intent of this paper, therefore, is to present the detailed analytical study of the aerodynamic heating problem. [DOI: 10.1115/1.4001754] C1 [Arnas, A. Oezer; Boettner, Daisie D.; Tamm, Gunnar; Norberg, Seth A.; Whipple, Jason R.; Benson, Michael J.; VanPoppel, Bret P.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Arnas, AO (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM ozer.arnas@usma.edu NR 15 TC 0 Z9 0 U1 2 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD DEC PY 2010 VL 132 IS 12 AR 124501 DI 10.1115/1.4001754 PG 4 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 653KA UT WOS:000282088600019 ER PT J AU Sturm, M Taras, B Liston, GE Derksen, C Jonas, T Lea, J AF Sturm, Matthew Taras, Brian Liston, Glen E. Derksen, Chris Jonas, Tobias Lea, Jon TI Estimating Snow Water Equivalent Using Snow Depth Data and Climate Classes SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID SEASONAL SNOW; UNITED-STATES; COVER DATA; SEA-ICE; MODEL; ALASKA; PARAMETERIZATION; VARIABILITY; SYSTEM; LIDAR AB In many practical applications snow depth is known, but snow water equivalent (SWE) is needed as well. Measuring SWE takes similar to 20 times as long as measuring depth, which in part is why depth measurements outnumber SWE measurements worldwide. Here a method of estimating snow bulk density is presented and then used to convert snow depth to SWE. The method is grounded in the fact that depth varies over a range that is many times greater than that of bulk density. Consequently, estimates derived from measured depths and modeled densities generally fall close to measured values of SWE. Knowledge of snow climate classes is used to improve the accuracy of the estimation procedure. A statistical model based on a Bayesian analysis of a set of 25 688 depth-density-SWE data collected in the United States, Canada, and Switzerland takes snow depth, day of the year, and the climate class of snow at a selected location from which it produces a local bulk density estimate. When converted to SWE and tested against two continental-scale datasets, 90% of the computed SWE values fell within +/- 8 cm of the measured values, with most estimates falling much closer. C1 [Sturm, Matthew] USA, CRREL Alaska, Ft Wainwright, AK 99712 USA. [Taras, Brian] Alaska Dept Fish & Game, Fairbanks, AK USA. [Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Derksen, Chris] Environm Canada, Div Climate Res, Toronto, ON, Canada. [Jonas, Tobias] WSL Inst Snow & Avalanche Res SLF, Davos, Switzerland. [Lea, Jon] Oregon State Off, Natl Resource Conservat Serv, Portland, OR USA. RP Sturm, M (reprint author), USA, CRREL Alaska, POB 35170, Ft Wainwright, AK 99712 USA. EM msturm@crrel.usace.army.mil FU U.S. Army Cold Regions Research and Engineering Laboratory; National Science Foundation, Office of Polar Program [0629279, 0632398, 0632131] FX We express our thanks to several generations of NRCS, Canadian, and Swiss snow researchers, unknown to us by name, who painstaking collected the data used here. In our research programs, we thank Jon Holmgren, Eric Pyne, April Cheuvront, Wylie Bogren, Chris Polashenski, Paul Heflinger, Arvid Silis, Peter Toose, Andrew Rees, and others for the depth and SWE measurements they made in the field. James Sickman and John Melack provided snow data from Tokopah Basin. Mark Williams provided data from Niwot Ridge in Colorado. CLPX data were provided by Don Cline and Kelly Elder. Noah Molotch suggested the inclusion of Table 5 as a second test of model results. Ron Barry helped develop the Bayesian model. Ross Brown generously provided the test dataset. This work was supported by the U.S. Army Cold Regions Research and Engineering Laboratory and by the National Science Foundation, Office of Polar Program, Grants 0629279, 0632398, and 0632131. NR 79 TC 78 Z9 79 U1 6 U2 40 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2010 VL 11 IS 6 BP 1380 EP 1394 DI 10.1175/2010JHM1202.1 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 705ZE UT WOS:000286178800013 ER PT J AU Solomon, NP Clark, HM AF Solomon, Nancy Pearl Clark, Heather M. TI Quantifying Orofacial Muscle Stiffness using Damped Oscillation SO JOURNAL OF MEDICAL SPEECH-LANGUAGE PATHOLOGY LA English DT Article DE muscle tone; muscle stiffness; tongue (lingual); cheek (buccal); measurement; assessment AB Muscle stiffness can reflect muscle tone, often presumed to be aberrant in persons with dysarthria. This exploratory study used the Myoton-3 to assess stiffness of the lateral tongue and mid-cheek in 10 participants with various neurologic disorders-primarily lower motor neuron (n = 6), primarily upper motor neuron (n = 4), and neurologically normal adults (n = 4). The Myoton delivered a 25-ms pulse perturbation to the surface of the structure of interest and sensed the response with an internal accelerometer. The resulting acceleration curve was used to determine frequency of oscillation and decrement of damping; stiffness was derived from the linear displacement of tissue per force of the perturbation. Tongue stiffness was significantly lower for the LMN group than for the normal control group, consistent with the assumption that hypotonia accompanies flaccidity. Tongue stiffness did not differ for the UMN group, nor did cheek stiffness, oscillation frequency or decrement differ between any groups. These preliminary findings indicate that stiffness can be determined from the surface of the tongue and cheek, and may be indicative of low muscle tone in LAIN lesions. Although methodologic challenges remain, this novel approach has the potential to quantify orofacial muscle stiffness and document potential changes in muscle tone with disease and treatment. C1 [Solomon, Nancy Pearl] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Clark, Heather M.] Appalachian State Univ, Boone, NC 28608 USA. RP Solomon, NP (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Nancy.P.Solomon@us.army.mil FU American Speech-Language-Hearing Foundation FX The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army or U.S. Government. We gratefully acknowledge the assistance of Katie Dietrich-Burns, Matthew Makashay, and Katy Teixeira, and the generous support of the first author's research program by the American Speech-Language-Hearing Foundation. NR 11 TC 4 Z9 4 U1 1 U2 1 PU DELMAR CENGAGE LEARNING PI FLORENCE PA PO BOX 6904, FLORENCE, KY 41022-6904 USA SN 1065-1438 J9 J MED SPEECH-LANG PA JI J. Med. Speech-Lang. Pathol. PD DEC PY 2010 VL 18 IS 4 BP 120 EP 124 PG 5 WC Audiology & Speech-Language Pathology; Clinical Neurology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology GA 688QO UT WOS:000284866700019 ER PT J AU Neumeister, H Whitaker, KW Hofmann, HA Preuss, T AF Neumeister, H. Whitaker, K. W. Hofmann, H. A. Preuss, T. TI Social and Ecological Regulation of a Decision-Making Circuit SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article ID AFRICAN CICHLID FISH; GOLDFISH CARASSIUS-AURATUS; QUANTITATIVE BEHAVIORAL OBSERVATIONS; CENTRAL INHIBITORY SYNAPSES; MAUTHNER CELL; HAPLOCHROMIS-BURTONI; ESCAPE BEHAVIOR; COMMAND NEURON; PREDATION RISK; SEROTONERGIC FACILITATION AB Neumeister H, Whitaker KW, Hofmann HA, Preuss T. Social and ecological regulation of a decision-making circuit. J Neurophysiol 104: 3180 -3188, 2010. First published October 6, 2010; doi: 10.1152/jn.00574.2010. Ecological context, sensory inputs, and the internal physiological state are all factors that need to be integrated for an animal to make appropriate behavioral decisions. However, these factors have rarely been studied in the same system. In the African cichlid fish Astatotilapia burtoni, males alternate between two phenotypes based on position in a social hierarchy. When dominant (DOM), fish display bright body coloration and a wealth of aggressive and reproductive behavioral patterns that make them conspicuous to predators. Subordinate (SUB) males, on the other hand, decrease predation risk by adopting cryptic coloration and schooling behavior. We therefore hypothesized that DOMs would show enhanced startleescape responsiveness to compensate for their increased predation risk. Indeed, behavioral responses to sound clicks of various intensities showed a significantly higher mean startle rate in DOMs compared with SUBs. Electrophysiological recordings from the Mauthner cells (M-cells), the neurons triggering startle, were performed in anesthetized animals and showed larger synaptic responses to sound clicks in DOMs, consistent with the behavioral results. In addition, the inhibitory drive mediated by interneurons (passive hyperpolarizing potential [PHP] cells) presynaptic to the M-cell was significantly reduced in DOMs. Taken together, the results suggest that the likelihood for an escape to occur for a given auditory stimulus is higher in DOMs because of a more excitable M-cell. More broadly, this study provides an integrative explanation of an ecological and social trade-off at the level of an identifiable decision-making neural circuit. C1 [Neumeister, H.; Preuss, T.] CUNY, Dept Psychol, Hunter Coll, New York, NY 10065 USA. [Whitaker, K. W.; Hofmann, H. A.] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA. [Hofmann, H. A.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Hofmann, H. A.] Univ Texas Austin, Sect Integrat Biol, Austin, TX 78712 USA. [Whitaker, K. W.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Preuss, T (reprint author), CUNY, Dept Psychol, Hunter Coll, 695 Pk Ave, New York, NY 10065 USA. EM tpreuss@hunter.cuny.edu OI Hofmann, Hans/0000-0002-3335-330X FU National Science Foundation [0946637, 0751311]; Hunter College, City University of New York; Research Foundation of City University of New York; Alfred P. Sloan Foundation; Institute for Cellular and Molecular Biology at The University of Texas at Austin; Department of Defense Science, Mathematics and Research for Transformation FX This work was supported by National Science Foundation Grants 0946637 to T. Preuss and 0751311 to H. A. Hofmann, Hunter College, City University of New York to T. Preuss, Research Foundation of City University of New York to T. Preuss, the Alfred P. Sloan Foundation, the Institute for Cellular and Molecular Biology at The University of Texas at Austin to H. A. Hofmann, and the Department of Defense Science, Mathematics and Research for Transformation program to K. W. Whitaker. NR 83 TC 16 Z9 16 U1 0 U2 19 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD DEC PY 2010 VL 104 IS 6 BP 3180 EP 3188 DI 10.1152/jn.00574.2010 PG 9 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 695SK UT WOS:000285392700024 PM 20926612 ER PT J AU Wind, JJ Bell, RS Bank, WO Myseros, JS AF Wind, Joshua J. Bell, Randy S. Bank, William O. Myseros, John S. TI Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone SO JOURNAL OF NEUROSURGERY-PEDIATRICS LA English DT Article DE choroid plexus papilloma; papilloma; embolization; third ventricle ID CEREBROSPINAL-FLUID; TUMORS; CHILDHOOD; MANAGEMENT; CHILDREN; COMPLICATIONS AB The authors present the case of a 3 month old boy with a third ventricular tumor consistent with a choroid plexus papilloma This child presented with macrocephaly irritability inability to roll over and vomiting He was found to have an enlarged head circumference a full and tense fontanel splayed sutures and forced downward gaze Imaging revealed severe ventriculomegaly and a brightly enhancing third ventricular lesion consistent with papilloma Treatment planning Included placement of a ventriculoperitoneal shunt to treat hydrocephalus and to allow the child to grow prior to resection Due to the vascular nature of these tumors and the age of this child the tumor was embolized with a plan for eventual resection, however embolization resulted in involution and total regression of the tumor There is no residual disease at list follow up of 16 months In this specific scenario of a choroid plexus papilloma in an infant when operative intervention may be technically difficult and associated with significant morbidity embolization with close observation may be a valid treatment option If used the patient would need to be closely followed for evidence of residual or recurrent disease which would require operative intervention (DOI 10.3171/2010.9.PEDS1039) C1 [Myseros, John S.] Childrens Natl Med Ctr, Div Neurol Surg, Washington, DC 20010 USA. [Wind, Joshua J.] George Washington Univ, Dept Neurol Surg, Washington, DC USA. [Bell, Randy S.] Walter Reed Army Med Ctr, Dept Neurol Surg, Washington, DC 20307 USA. [Bell, Randy S.; Bank, William O.] Washington Hosp Ctr, Dept Intervent Neuroradiol, Washington, DC 20010 USA. RP Myseros, JS (reprint author), Childrens Natl Med Ctr, Div Neurol Surg, 111 Michigan Ave NW, Washington, DC 20010 USA. RI Wind, Joshua/D-5480-2013 OI Wind, Joshua/0000-0003-3443-8476 NR 16 TC 7 Z9 7 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1933-0707 J9 J NEUROSURG-PEDIATR JI J. Neurosurg.-Pediatr. PD DEC PY 2010 VL 6 IS 6 BP 579 EP 582 DI 10.3171/2010.9.PEDS1039 PG 4 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA 684QT UT WOS:000284565100012 PM 21121734 ER PT J AU Greathouse, DG Joshi, A AF Greathouse, David G. Joshi, Anand TI Radiculopathy of the Eighth Cervical Nerve SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE electromyography; magnetic resonance imaging; neck nerve conduction studies; ulnar nerve AB STUDY DESIGN: Resident's case problem. BACKGROUND: The C8 nerve root is the least commonly encountered of cervical radiculopathies. The purpose of this resident's case problem is to provide an unusual presentation of a C8 radiculopathy, without cervical or proximal upper quarter symptoms, diagnosed by a combination of physical examination, electromyography (EMG) and nerve conduction studies (NCSs), and imaging. DIAGNOSIS: A 49-year-old, right-hand-dominant male was referred to the EMG/NCS laboratory for a suspected left ulnar neuropathy at the elbow. A physical examination, NCS, and EMG were performed, and a C8 radiculopathy involving both the anterior and posterior primary rami was identified. Following the EMG and NCS evaluation, the patient had enhanced magnetic resonance imaging studies that confirmed a foraminal C7-T1 herniation and associated small central disc protrusion. The patient was then referred to neurosurgery for further consultation and subsequent surgical intervention. The patient underwent a C7-T1 laminectomy, mesial facetectomy, and foraminotomy, and excision of a herniated disk using an operating microscope. The neurosurgeon noted that there was a large disk herniation containing some disk material immediately anterior to the C8 motor root, that impinged directly on the motor root. One month postoperatively, the patient had decreased pain and numbness and tingling in his arm and his hand weakness had improved. DISCUSSION: The report illustrates the utility of a combination of physical examination, EMG and NCSs, and imaging in the diagnosis of a C8 radiculopathy in a patient presenting with forearm and hand symptoms but without cervical or upper quarter symptoms. LEVEL OF EVIDENCE: Diagnosis, level 4. J Orthop Sports Phys Ther 2010;40(12):811-817 doi:10.2519/jospt.2010.3187 C1 [Greathouse, David G.] Texas Phys Therapy Specialists, Clin Electrophysiol Serv, New Braunfels, TX USA. [Greathouse, David G.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Joshi, Anand] Spine Diagnost & Treatment Ctr, Austin, TX USA. RP Greathouse, DG (reprint author), 3211 Crystal Path, San Antonio, TX 78259 USA. EM greathoused1@yahoo.com NR 10 TC 2 Z9 2 U1 0 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2010 VL 40 IS 12 BP 811 EP 817 DI 10.2519/jospt.2010.3187 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 699JQ UT WOS:000285660100005 PM 20972345 ER PT J AU Decker, JF Lee, J Cortella, CA Polimeni, G Rohrer, MD Wozney, JM Hall, J Susin, C Wikesjo, UME AF Decker, John F. Lee, Jaebum Cortella, Carlo Alberto Polimeni, Giuseppe Rohrer, Michael D. Wozney, John M. Hall, Jan Susin, Cristiano Wikesjoe, Ulf M. E. TI Evaluation of Implants Coated With Recombinant Human Bone Morphogenetic Protein-2 and Vacuum-Dried Using the Critical-Size Supraalveolar Pen-Implant Defect Model in Dogs SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE Bone density; dental implants; osseointegration; osteogenesis; rhBMP-2 protein; recombinant; tissue engineering ID ALVEOLAR RIDGE AUGMENTATION; PROGNOSTIC-FACTORS; TITANIUM IMPLANTS; RADIOGRAPHIC OBSERVATIONS; HISTOLOGIC OBSERVATIONS; GRINDING TECHNIQUE; MOISTURE-CONTENT; REGENERATION; RHBMP-2; RHBMP-7/RHOP-1 AB Background: Endosseous implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a laboratory bench setting and air-dried induce relevant bone formation but also resident bone remodeling. Thus, the objective of this study is to evaluate the effect of implants fully or partially coated with rhBMP-2 and vacuum-dried using an industrial process on local bone formation and resident bone remodeling. Methods: Twelve male adult Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most corona I aspect with rhBMP-2 (coronal-load, six animals), or by immersion of the entire implant in a rhBMP-2 solution (soak-load, six animals) for a total of 30 mu g rhBMP-2 per implant. All implants were vacuum-dried. The animals were sacrificed at 8 weeks for histometric evaluation. Results: Clinical healing was unremarkable. Bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (+/- SE) 3.2 +/- 0.5 versus 3.6 +/- 0.3 mm, and 2.3 +/- 0.5 versus 2.6 +/- 0.8 mm(2) for coronal-load and soak-load implants, respectively (P>0.05). The corresponding bone density and bone implant contact registrations averaged 46.7% +/- 5.8% versus 31.6% +/- 4.4%, and 28% +/- 5.6% versus 36.9% +/- 3.4% (P>0.05). In contrast, resident bone remodeling was significantly influenced by the rhBMP-2 application protocol. Pen-implant bone density averaged 72.2% +/- 2.1% for coronal-load versus 60.6% +/- 4.7% for soak-load implants (P<0.05); the corresponding bone implant contact averaged 70.7% +/- 6.1% versus 47.2% +/- 6.0% (P<0.05). Conclusions: Local application of rhBMP-2 and vacuum-drying using industrial process seems to be a viable technology to manufacture implants that support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodeling without compromising local bone formation. J Periodontol 2010;81:1839-1849. C1 [Decker, John F.; Lee, Jaebum; Cortella, Carlo Alberto; Polimeni, Giuseppe; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Dept Periodont, Lab Appl Periodontal & Craniofacial Regenerat, Sch Dent, Augusta, GA 30912 USA. [Decker, John F.; Lee, Jaebum; Cortella, Carlo Alberto; Polimeni, Giuseppe; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Dept Oral Biol, Lab Appl Periodontal & Craniofacial Regenerat, Sch Dent, Augusta, GA 30912 USA. [Decker, John F.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. [Cortella, Carlo Alberto] Univ Vita Salute San Raffaele, Hosp San Raffaele, Dept Dent, Milan, Italy. [Rohrer, Michael D.] Univ Minnesota, Sch Dent, Hard Tissue Lab, Minneapolis, MN 55455 USA. [Wozney, John M.] Pfizer, Tissue Repair, Cambridge, MA USA. [Hall, Jan] Nobel Biocare AB, Res & Dev, Gothenburg, Sweden. RP Wikesjo, UME (reprint author), Med Coll Georgia, Dept Periodont, Lab Appl Periodontal & Craniofacial Regenerat, Sch Dent, 1120 15th St,AD 1432, Augusta, GA 30912 USA. EM uwikesjo@mcg.edu RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009 OI Wikesjo, Ulf/0000-0003-1607-0583 FU Nobel Biocare AB, Gothenburg, Sweden FX The authors thank Dr. Nancy A. Rodriguez for veterinary support; Cedrick Bouey and Jamie Frank for animal technical care and husbandry (Laboratory Animal Services, Medical College of Georgia, Augusta, Georgia); Hari S. Prasad (Hard Tissue Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN) for expert histotechnical preparations; and Kimberly Curtis (Department of Periodontics, Medical College of Georgia School of Dentistry, Augusta, Georgia) for administrative support. This study was supported by a grant from Nobel Biocare AB, Gothenburg, Sweden. Dr. Hall is a Senior Scientist at Nobel Biocare AB, Gothenburg, Sweden, and Dr. Wozney is Assistant Vice President at Pfizer (previously Wyeth Research and Genetics Institute), Cambridge, MA. Dr. Wikesjo was previously employed (Head, Preclinical Research Oral Maxillofacial Studies) by Genetics Institute, and has served as a consultant to Wyeth Research; he presently serves as consultant to Nobel Biocare AB. Drs. Decker, Lee, Cortella, Polimeni, Rohrer, and Susin report no financial relationships related to any products involved in this study. NR 34 TC 9 Z9 9 U1 0 U2 2 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD DEC PY 2010 VL 81 IS 12 BP 1839 EP 1849 DI 10.1902/jop.2010.100220 PG 11 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 696GP UT WOS:000285430200016 PM 20629551 ER PT J AU Polyakov, IV Timokhov, LA Alexeev, VA Bacon, S Dmitrenko, IA Fortier, L Frolov, IE Gascard, JC Hansen, E Ivanov, VV Laxon, S Mauritzen, C Perovich, D Shimada, K Simmons, HL Sokolov, VT Steele, M Toolen, J AF Polyakov, Igor V. Timokhov, Leonid A. Alexeev, Vladimir A. Bacon, Sheldon Dmitrenko, Igor A. Fortier, Louis Frolov, Ivan. E. Gascard, Jean-Claude Hansen, Edmond Ivanov, Vladimir V. Laxon, Seymour Mauritzen, Cecile Perovich, Don Shimada, Koji Simmons, Harper L. Sokolov, Vladimir T. Steele, Michael Toolen, John TI Arctic Ocean Warming Contributes to Reduced Polar Ice Cap SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID SEA-ICE; ATLANTIC WATER; TURBULENT DISSIPATION; KASHEVAROV BANK; DIURNAL TIDES; HEAT FLUXES; OKHOTSK SEA; VARIABILITY; HALOCLINE; THERMOCLINE AB Analysis of modern and historical observations demonstrates that the temperature of the intermediate-depth (150-900 m) Atlantic water (AW) of the Arctic Ocean has increased in recent decades. The AW warming has been uneven in time; a local similar to 1 degrees C maximum was observed in the mid-1990s, followed by an intervening minimum and an additional warming that culminated in 2007 with temperatures higher than in the 1990s by 0.24 degrees C. Relative to climatology from all data prior to 11999, the most extreme 2007 temperature anomalies of up to 1 degrees C and higher were observed in the Eurasian and Makarov Basins. The AW warming was associated with a substantial (up to 75-90 m) shoaling of the upper AW boundary in the central Arctic Ocean and weakening of the Eurasian Basin upper-ocean stratification. Taken together, these observations suggest that the changes in the Eurasian Basin facilitated greater upward transfer of AW heat to the ocean surface layer. Available limited observations and results from a ID ocean column model support this surmised upward spread of AW heat through the Eurasian Basin halocline. Experiments with a 3D coupled ice-ocean model in turn suggest a loss of 28-35 cm of ice thickness after similar to 50 yr in response to the 0.5 W m(-2) increase in AW ocean heat flux suggested by the 1D model. This amount of thinning is comparable to the 29 cm of ice thickness loss due to local atmospheric thermodynamic forcing estimated from observations of fast-ice thickness decline. The implication is that AW warming helped precondition the polar ice cap for the extreme ice loss observed in recent years. C1 [Polyakov, Igor V.; Alexeev, Vladimir A.; Ivanov, Vladimir V.; Simmons, Harper L.] Univ Alaska Fairbanks, Int Arctic Res Ctr, Fairbanks, AK 99709 USA. [Timokhov, Leonid A.; Frolov, Ivan. E.; Ivanov, Vladimir V.; Sokolov, Vladimir T.] Arctic & Antarctic Res Inst, St Petersburg 199226, Russia. [Bacon, Sheldon] Natl Oceanog Ctr, Southampton, Hants, England. [Dmitrenko, Igor A.] Univ Kiel, Leibniz Inst Marine Sci, IFM GEOMAR, Kiel, Germany. [Fortier, Louis] Univ Laval, Quebec City, PQ, Canada. [Gascard, Jean-Claude] Univ Paris 06, LOCEAN, Paris, France. [Hansen, Edmond] Norwegian Polar Res Inst, Tromso, Norway. [Laxon, Seymour] UCL, London, England. [Mauritzen, Cecile] Norwegian Meteorol Inst, Oslo, Norway. [Perovich, Don] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Shimada, Koji] Tokyo Univ Marine Sci & Technol, Tokyo, Japan. [Steele, Michael] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. [Toolen, John] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Ivanov, Vladimir V.] SAMS, Scottish Marine Inst, Oban, Argyll, Scotland. RP Polyakov, IV (reprint author), Univ Alaska Fairbanks, Int Arctic Res Ctr, Fairbanks, AK 99709 USA. EM igor@iarc.uaf.edu RI alexeev, vladimir/B-2234-2010; Laxon, Seymour/C-1644-2008; Bacon, Sheldon/B-1519-2013; Ivanov, Vladimir/J-5979-2014; SHIMADA, Koji/O-1913-2014 OI alexeev, vladimir/0000-0003-3519-2797; Bacon, Sheldon/0000-0002-2471-9373; FU JAMSTEC; NOAA; NSF; NASA; BMBF; UK NERC FX This study was supported by JAMSTEC (IP and VI), NOAA (IP, VI, and ID), NSF (IP, VA, VI, ID, JT, and MS), NASA (IP and VI), BMBF (ID), and UK NERC (SB) grants. We thank J. Moss for help with the graphics and U. Bhatt, U. Schauer, B. Rude Is, and J. Walsh for insightful comments. The findings presented in this paper are of the authors and not NSF/NOAA. NR 60 TC 123 Z9 127 U1 6 U2 72 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 EI 1520-0485 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD DEC PY 2010 VL 40 IS 12 BP 2743 EP 2756 DI 10.1175/2010JPO4339.1 PG 14 WC Oceanography SC Oceanography GA 708LH UT WOS:000286362800011 ER PT J AU Dagnon, K Thellen, C Ratto, J D'Souza, N AF Dagnon, Koffi L. Thellen, Christopher Ratto, Jo Ann D'Souza, Nandika A. TI Physical and Thermal Analysis of the Degradation of Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) Coated Paper in a Constructed Soil Medium SO JOURNAL OF POLYMERS AND THE ENVIRONMENT LA English DT Article DE Kraft paper; Biodegradable packaging; Coating; Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) ID MECHANICAL-PROPERTIES; FUNCTIONAL-PROPERTIES; WATER RESISTANCE; BIODEGRADATION; POLYHYDROXYALKANOATES; BARRIER; POLYESTERS; POLYMERS; CHITOSAN; PLASTICS AB The degradation of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) coated brown Kraft paper and its components in a constructed soil environment was investigated. Soil burial tests were carried out over 8 weeks. Weight loss measurements, photographic analysis, environmental scanning electron microscopy (ESEM), dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) were conducted to assess the physical, structural, mechanical and thermal behavior before and after the soil burial test. Paper showed the highest physical degradation and weight loss. With respect to the control samples, the stiffness of the partially degraded samples decreased. The overall crystallinity of the biopolymer and the coated paper was affected significantly by burial. The pure biopolymer's weight loss was substantially enhanced when coated on paper. This result reveals a possible increased microbial population in the coated paper relative to the pure biopolymer. C1 [Dagnon, Koffi L.; D'Souza, Nandika A.] Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. [Thellen, Christopher; Ratto, Jo Ann] USA, Natick Soldier Res Dev & Engn Ctr, Adv Mat Engn Team, Natick, MA 01760 USA. RP D'Souza, N (reprint author), Univ N Texas, Dept Mat Sci & Engn, POB 305310, Denton, TX 76203 USA. EM ndsouza@unt.edu OI DSouza, Nandika/0000-0002-8553-0347 FU Department of Defense FX Financial Support from the Department of Defense - Strategic Environmental Research and Development Program (SERDP), is gratefully acknowledged. NR 38 TC 5 Z9 7 U1 1 U2 19 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1566-2543 J9 J POLYM ENVIRON JI J. Polym. Environ. PD DEC PY 2010 VL 18 IS 4 BP 510 EP 522 DI 10.1007/s10924-010-0231-y PG 13 WC Engineering, Environmental; Polymer Science SC Engineering; Polymer Science GA 682BS UT WOS:000284374500008 ER PT J AU Troiano, E Underwood, JH Parker, AP Mossey, C AF Troiano, E. Underwood, J. H. Parker, A. P. Mossey, C. TI Post-Autofrettage Thermal Treatment and Its Effect on Reyielding of High Strength Pressure Vessel Steels SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The autofrettage process of a thick walled pressure vessel involves applying tensile plastic strain at the bore of the vessel, which reverses during unloading and results in favorable compressive residual stresses at the bore and prolongs the fatigue life of the component In thick walled pressure vessels this process can be accomplished with whet a hydraulic, or mechanical overloading process The Bauschinger effect, which is observed in many of the materials used in thick walled pressure vessels, is a phenomenon, which results in lower compressive residual stresses than those predicted with classic ideal isotropic hardening The phenomenon is a strong function of the amount of prior tensile plastic strain A novel idea, which involves a multiple autofrettage processes. has been proposed by the present authors This process requires a low temperature post-autofrettage thermal treatment, which effectively returns the material to its original yield conditions with minimal effect on its residual stress state Details of this low temperature thermal treatment cure proprietary A subsequent second autofrettage process generates a significantly lower amount of plastic strain during the tensile reloading and results in higher compressive residual stresses This paper reports the details of the exploratory tests involving tensile and compressive loading of a test coupon. followed by a low temperature post-plastic straining thermal treatment, and subsequent reloading in tension and compression Finally results of a full scale safe maximum pressure (SNIP) lest of pressure vessels are presented, these tests indicate a significant increase (11%) in SMP [DOI 10 1115/1 4001209] C1 [Troiano, E.; Underwood, J. H.; Mossey, C.] USA, RDT&E Ctr, Watervliet, NY 12189 USA. [Parker, A. P.] Cranfield Univ, Swindon SN6 8LA, Wilts, England. RP Troiano, E (reprint author), USA, RDT&E Ctr, Watervliet, NY 12189 USA. NR 10 TC 0 Z9 0 U1 1 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD DEC PY 2010 VL 132 IS 6 AR 061402 PG 5 WC Engineering, Mechanical SC Engineering GA 690WN UT WOS:000285040400015 ER PT J AU Codier, E Muneno, L Franey, K Matsuura, F AF Codier, E. Muneno, L. Franey, K. Matsuura, F. TI Is emotional intelligence an important concept for nursing practice? SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING LA English DT Editorial Material ID INTUITION; NURSES; IMPACT C1 [Codier, E.] Univ Hawaii Manoa, Honolulu, HI 96822 USA. [Muneno, L.] Queens Med Ctr, Pain & Palliat Care Dept, Honolulu, HI USA. [Franey, K.] Tripler Army Med Ctr, Med Branch, Honolulu, HI 96859 USA. RP Codier, E (reprint author), Univ Hawaii Manoa, Honolulu, HI 96822 USA. EM codier@hawaii.edu NR 38 TC 13 Z9 14 U1 1 U2 7 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1351-0126 J9 J PSYCHIATR MENT HLT JI J. Psychiatr. Ment. Health Nurs. PD DEC PY 2010 VL 17 IS 10 BP 940 EP 948 DI 10.1111/j.1365-2850.2010.01610.x PG 9 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 681BF UT WOS:000284280500012 PM 21121178 ER PT J AU Guicheteau, J Christesen, S Emge, D Tripathi, A AF Guicheteau, Jason Christesen, Steven Emge, Darren Tripathi, Ashish TI Bacterial mixture identification using Raman and surface-enhanced Raman chemical imaging SO JOURNAL OF RAMAN SPECTROSCOPY LA English DT Article DE Raman chemical imaging; surface-enhanced Raman; bacillus; PCA ID MASS-SPECTROMETRY; SPECTROSCOPY; CELLS; DISCRIMINATION; CLASSIFICATION; MICROSCOPY; SCATTERING; CULTURE; TISSUE; SILVER AB The ability of normal Raman and surface-enhanced Raman scattering (SERS) to identify and detect bacteria has shown great success in recent studies. The addition of silver nanoparticles to bacterial samples not only results in an enhanced Raman signal, but it also suppresses the native fluorescence associated with biological material. In this report, Raman chemical imaging (RCI) was used to analyze individual bacteria and complex mixtures of spores and vegetative cells. RCI uses every pixel or a binned pixel group (BPG) of the Raman camera as an independent Raman spectrograph, allowing collection of spatially resolved Raman spectra. The advantage of this technique resides primarily in the analysis of samples in complex backgrounds without the need for physically isolating or purifying the sample. Using a chemical imaging Raman microscope, we compare normal RCI to SERS-assisted chemical imaging of mixtures of bacteria. In both cases, we are able to differentiate single bacterium in the Raman microscope's field of view, with a 60-fold reduction in image acquisition time and a factor of 10 increase in the signal-to-noise ratio for SERS chemical imaging over normal RCI. Published in 2010 by John Wiley & Sons, Ltd. C1 [Guicheteau, Jason] USA, RDECOM, ECBC, ATTN RDCB DRD L E5560, Aberdeen Proving Ground, MD 21010 USA. [Tripathi, Ashish] Sci Applicat Int Corp, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Guicheteau, J (reprint author), USA, RDECOM, ECBC, ATTN RDCB DRD L E5560, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jason.guicheteau@us.army.mil NR 29 TC 22 Z9 22 U1 0 U2 44 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0377-0486 J9 J RAMAN SPECTROSC JI J. Raman Spectrosc. PD DEC PY 2010 VL 41 IS 12 BP 1632 EP 1637 DI 10.1002/jrs.2601 PG 6 WC Spectroscopy SC Spectroscopy GA 705PY UT WOS:000286151400010 ER PT J AU Wu, XW Baer, LA Wolf, SE Wade, CE Walters, TJ AF Wu, Xiaowu Baer, Lisa A. Wolf, Steven E. Wade, Charles E. Walters, Thomas J. TI The Impact of Muscle Disuse on Muscle Atrophy in Severely Burned Rats SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE hindlimb unloading; thermal injury; skeletal muscle; muscle function ID SKELETAL-MUSCLE; HINDLIMB SUSPENSION; GROWTH-HORMONE; CONTRACTILE PROPERTIES; PROTEIN BREAKDOWN; THERMAL-INJURY; SOLEUS MUSCLE; BED REST; MASS; CHILDREN AB Background Severe burn induces a sustained hypermetabolic response, which causes long term loss of muscle mass and decrease in muscle strength In this study, we sought to determine whether muscle disuse has additional impact on muscle atrophy after severe burn using a rat model combining severe cutaneous burn and hindlimb unloading Methods Forty Sprague Dawley rats (approximate to 300 g) were randomly assigned to sham ambulatory (S/A), sham hindlimb unloading (S/HLU), burn ambulatory (B/A), or burn hindlimb unloading (B/HLU) groups Rats received a 40% total body surface (TBSA) full thickness scald burn, and rats with hindlimb unloading were placed in a tail traction system At d 14, lean body mass (LBM) was determined using DEXA scan, followed by measurement of the isometric mechanical properties in the predominantly fast twitch plantaris muscle (PL) and the predominantly slow twitch soleus muscle (SL) Muscle weight (wt), protein wt, and wet/dry wt were determined Results At d 14, body weight had decreased significantly in all treatment groups, B/HLU resulted in significantly greater loss compared with the B/A, S/HLU, and S/A The losses could be attributed to loss of LBM PL muscle wt and Po were lowest in the B/HLU group (< 0 05 versus S/A, S/HLU, or B/A) SL muscle wt and Po were significantly less in both S/HLU and B/HLU compared with that of S/A and B/A, no significant difference was found between S/HLU and B/HLU Conclusions Cutaneous burn and hindlimb unloading have an additive effect on muscle atrophy, characterized by loss of muscle mass and decrease in muscle strength in both fast (PL) and slow (SL) twitch muscles Of the two, disuse appeared to be the dominant factor for continuous muscle wasting after acute burn in this model (C) 2010 Elsevier Inc All rights reserved C1 [Wu, Xiaowu; Baer, Lisa A.; Wolf, Steven E.; Walters, Thomas J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wu, Xiaowu; Wolf, Steven E.; Wade, Charles E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Wu, XW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 FU Combat Casualty Care Division United States Army Medical Research and Materiel Command; Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund; Juvenile Diabetes Research Foundation; National Institutes of Health [1 R01 GM063120 04] FX This study was supported by the Combat Casualty Care Division United States Army Medical Research and Materiel Command and the Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund a congressionally directed program jointly managed by the USA MRMC NIH NASA and the Juvenile Diabetes Research Foundation and The National Institutes of Health (1 R01 GM063120 04) NR 49 TC 15 Z9 15 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD DEC PY 2010 VL 164 IS 2 BP E243 EP E251 DI 10.1016/j.jss.2010.08.032 PG 9 WC Surgery SC Surgery GA 690AO UT WOS:000284972600030 PM 20888588 ER PT J AU Liu, K Ayers, P Howard, H Anderson, A AF Liu, Kun Ayers, Paul Howard, Heidi Anderson, Alan TI Lateral slide sinkage tests for a tire and a track shoe SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Lateral force; Lateral displacement; Slide sinkage; Static sinkage ID SOIL; DISTURBANCE; COMPACTION; TRACTION AB Previous field studies have shown the influence of turning vehicles on rut formation or sinkage. In order to further investigate the relationships, laboratory tests were conduced on a 14.5-20.3 6-PR trailer tire and an Armored Personnel Carrier (APC) track shoe in sand. Lateral displacements, and resulting lateral forces, were applied to the tire and track shoe under constant normal forces. The tire was pulled laterally and the track shoe was pulled back and forth to represent actual movement during vehicle turning. Results show that the lateral force and lateral displacement generated by turning maneuver affect sinkage severely for wheeled and tracked vehicles. The final sinkage caused by the lateral force for the tire is 3-5 times to the static sinkage. For the track shoe, the final sinkage caused by the lateral displacement is about three times to the static sinkage. (C) 2010 Published by Elsevier Ltd. on behalf of ISTVS. C1 [Liu, Kun; Ayers, Paul] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Howard, Heidi; Anderson, Alan] USA, Engineer Res & Dev Ctr ERDC, Construct Engn Res Lab CERL, Champaign, IL 61822 USA. RP Ayers, P (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu FU Environmental Security Technology Certification Program (ESTCP) [SI-0815] FX We are grateful to the Environmental Security Technology Certification Program (ESTCP) Project SI-0815 for providing support for this study. NR 19 TC 0 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD DEC PY 2010 VL 47 IS 6 BP 407 EP 414 DI 10.1016/j.jterra.2010.05.003 PG 8 WC Engineering, Environmental SC Engineering GA 656SX UT WOS:000282358000005 ER PT J AU Huebschman, BD AF Huebschman, Benjamin D. TI The use of frequency resolution in echolocation for modeling three dimensional environments SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID BATS AB Bats use echolocation to navigate three dimensional obstacles while locating, identifying, and engaging targets. A theory is offered of image processing during the search and navigation phase of echolocation that uses Doppler frequency shifts. The information in frequency changes across the angle of elevation can be used to generate a three dimensional model of the environment when combined with the timing and the relative amplitude of the returned signals. The mathematics of frequency shifts for an emitter traveling at a large fraction of the velocity of propagation (c) is presented. Reported behavior that can be explained by this phenomenon is discussed. (c) 2010 Acoustical Society of America C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Huebschman, BD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM benjamin.huebschman@us.army.mil NR 15 TC 0 Z9 0 U1 2 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 2010 VL 128 IS 6 BP EL384 EP EL389 DI 10.1121/1.3514154 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 704OF UT WOS:000286061600006 PM 21218862 ER PT J AU Long, J AF Long, Jeremiah TI Combat Radiology: A Unique Opportunity for Patient-Centered Radiology SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, US Marine Corps, Dept Radiol, Washington, DC 20307 USA. RP Long, J (reprint author), Walter Reed Army Med Ctr, US Marine Corps, Dept Radiol, 6900 Georgia Ave,NW,Bldg 2,Room 1G05, Washington, DC 20307 USA. EM jeremiah.r.long@us.army.mil NR 7 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD DEC PY 2010 VL 7 IS 12 BP 915 EP 917 DI 10.1016/j.jacr.2010.06.016 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA V23SV UT WOS:000208363400004 PM 21129680 ER PT J AU Rueda, LM Li, C Kim, HC Klein, TA Foley, DH Wilkerson, RC AF Rueda, Leopoldo M. Li, Cong Kim, Heung Chul Klein, Terry A. Foley, Desmond H. Wilkerson, Richard C. TI ANOPHELES BELENRAE, A POTENTIAL VECTOR OF PLASMODIUM VIVAX IN THE REPUBLIC OF KOREA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Anopheles belenrae; Plasmodium vivax; Culicidae; Hyrcanus Group; Korea ID MALARIA AB The malarial parasite, Plasmodium vivax, was detected in 4 species of Anopheles (Hyrcanus Group) mosquitoes, namely An. kleini, An. pullus, An. belenrae, and An. sinensis, from Gyeonggi Province, Republic of Korea (ROK). This study confirmed that An. belenrae was infected by P. vivax, and implicated this species as a potential vector of vivax malaria in the ROK. C1 [Rueda, Leopoldo M.; Li, Cong; Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, Silver Spring, MD 20910 USA. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. [Kim, Heung Chul] 168th Multifunct Med Battal, Med Detachment 5, Med Brigade 65, Unit 15247, APO, AP 96205 USA. [Rueda, Leopoldo M.] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, Suitland, MD 20646 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 FU Global Emerging Infections Surveillance and Response Systems of the Armed Forces Health Surveillance Center, Silver Spring, MD FX Thanks to personnel of the 5th Medical Detachment, and staff of 65th Medical Brigade, U.S. Army, ROK, for field collections of mosquito specimens; and J. Pecor and Walter Reed Biosystematics Unit staff for curatorial help. We are grateful to Y. M. Huang, C. R. Summers, and B. P. Rueda for helpful reviews of the manuscript. Funding for this work was provided by the Global Emerging Infections Surveillance and Response Systems of the Armed Forces Health Surveillance Center, Silver Spring, MD. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 14 TC 11 Z9 11 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2010 VL 26 IS 4 BP 430 EP 432 DI 10.2987/10-6057.1 PG 3 WC Entomology SC Entomology GA 697QI UT WOS:000285529800009 PM 21290939 ER PT J AU Turell, MJ Dohm, DJ Geden, CJ Hogsette, JA Linthicum, KJ AF Turell, Michael J. Dohm, David J. Geden, Christopher J. Hogsette, Jerome A. Linthicum, Kenneth J. TI POTENTIAL FOR STABLE FLIES AND HOUSE FLIES (DIPTERA: MUSCIDAE) TO TRANSMIT RIFT VALLEY FEVER VIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE RVF; vector; mechanical transmission; North America; emerging disease potential ID NORTH-AMERICAN MOSQUITOS; VECTOR COMPETENCE; SAUDI-ARABIA; CULEX-ZOMBAENSIS; SOUTH-AFRICA; EPIDEMIC; CULICIDAE; EGYPT AB Rift Valley fever (RVF), a disease of ruminants and humans, has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands of human infections and major economic disruption due to loss of livestock and to trade restrictions. As indicated by the rapid spread of West Nile viral activity across North America since its discovery in 1999 and the rapid and widespread movement of chikungunya virus from Africa throughout the Indian Ocean Islands to Asia and Europe, an introduced exotic arbovirus can be rapidly and widely established across wide geographical regions. Although RVF virus (RVFV) is normally transmitted by mosquitoes, we wanted to determine the potential for this virus to replicate in 2 of the most globally distributed and common higher flies: house flies, Musca domestica, and stable flies, Stomoxys calcitrans. Neither species supported the replication of RVFV, even after intrathoracic inoculation. However, S. calcitrans was able to mechanically transmit RVFV to susceptible hamsters (Mesocricetus auratus) after probing on infected hamsters with high viral titers. Therefore, S. calcitrans, because of its close association with domestic animals that serve as amplifying hosts of RVFV, should be considered a possible mechanical vector of RVFV, and it may contribute to the rapid spread of a RVF outbreak. Other Stomoxys species present in Africa and elsewhere may also play similar roles. C1 [Turell, Michael J.; Dohm, David J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Geden, Christopher J.; Hogsette, Jerome A.; Linthicum, Kenneth J.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. RP Turell, MJ (reprint author), USA, Div Virol, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. FU US Department of Defense through the Armed Forces Pest Management Board FX The work was supported in part by a grant from the Deployed War-Fighter Protection Research Program funded by the US Department of Defense through the Armed Forces Pest Management Board. NR 27 TC 9 Z9 9 U1 0 U2 15 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2010 VL 26 IS 4 BP 445 EP 448 DI 10.2987/10-6070.1 PG 4 WC Entomology SC Entomology GA 697QI UT WOS:000285529800013 PM 21290943 ER PT J AU Ball, CG Navsaria, P Kirkpatrick, AW Vercler, C Dixon, E Zink, J Laupland, KB Lowe, M Salomone, JP Dente, CJ Wyrzykowski, AD Hameed, SM Widder, S Inaba, K Ball, JE Rozycki, GS Montgomery, SP Hayward, T Feliciano, DV AF Ball, Chad G. Navsaria, Pradeep Kirkpatrick, Andrew W. Vercler, Christian Dixon, Elijah Zink, John Laupland, Kevin B. Lowe, Michael Salomone, Jeffrey P. Dente, Christopher J. Wyrzykowski, Amy D. Hameed, S. Morad Widder, Sandy Inaba, Kenji Ball, Jill E. Rozycki, Grace S. Montgomery, Sean P. Hayward, Thomas Feliciano, David V. TI The Impact of Country and Culture on End-of-Life Care for Injured Patients: Results From an International Survey SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Annual Scientific Meeting of the Trauma-Association-of-Canada CY MAY 06-07, 2010 CL Halifax, CANADA SP Trauma Assoc Canada DE Trauma; End-of-life; Withdrawal of treatment ID INTENSIVE-CARE; SUSTAINING TREATMENTS; CRITICALLY-ILL; CARDIAC DEATH; UNITED-STATES; DECISION-MAKING; TRAUMA PATIENTS; FAMILY-MEMBERS; ORGAN DONATION; PHYSICIANS AB Background: Up to 20% of all trauma patients admitted to an intensive care unit die from their injuries. End-of-life decision making is a variable process that involves prognosis, predicted functional outcomes, personal beliefs, institutional resources, societal norms, and clinician experience. The goal of this study was to better understand end-of-life processes after major injury by comparing clinician viewpoints from various countries and cultures. Methods: A clinician-based, 38-question international survey was used to characterize the impacts of medical, religious, social, and system factors on end-of-life care after trauma. Results: A total of 419 clinicians from the United States (49%), Canada (19%), South Africa (11%), Europe (9%), Asia (8%), and Australasia (4%) completed the survey. In America, the admitting surgeon guided most end-of-life decisions (51%), when compared with all other countries (0-27%). The practice structure of American respondents also varied from other regions. Formal medical futility laws are rarely available (14-38%). Ethical consultation services are often accessible (29-98%), but rarely used (0-29%), and typically unhelpful (<30%). End-of-life decision making for patients with traumatic brain injuries varied extensively across regions with regard to the impact of patient age, Glasgow Coma Scale score, and clinician philosophy. Similar differences were observed for spinal cord injuries (age and functional level). The avail-ability and use of "donation after cardiac death" also varied substantially between countries. Conclusions: In this unique study, geographic differences in religion, practice composition, decision-maker viewpoint, and institutional resources resulted in significant variation in end-of-life care after injury. These disparities reflect competing concepts (patient autonomy, distributive justice, and religion). C1 [Ball, Chad G.; Vercler, Christian; Zink, John; Lowe, Michael; Salomone, Jeffrey P.; Dente, Christopher J.; Wyrzykowski, Amy D.; Ball, Jill E.; Rozycki, Grace S.; Feliciano, David V.] Emory Univ, Grady Mem Hosp, Dept Surg, Atlanta, GA 30322 USA. [Navsaria, Pradeep] Univ Cape Town, Dept Surg, Groote Schuur Hosp, ZA-7925 Cape Town, South Africa. [Kirkpatrick, Andrew W.; Dixon, Elijah; Laupland, Kevin B.] Univ Calgary, Dept Surg, Calgary, AB, Canada. [Hameed, S. Morad] Univ British Columbia, Dept Surg, Vancouver, BC V6T 1W5, Canada. [Widder, Sandy] Univ Alberta, Dept Surg, Edmonton, AB, Canada. [Inaba, Kenji] Univ So Calif, Dept Surg, Los Angeles, CA USA. [Montgomery, Sean P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Hayward, Thomas] Wishard Mem Hosp, Dept Surg, Indianapolis, IN USA. RP Ball, CG (reprint author), Emory Univ, Grady Mem Hosp, Dept Surg, Grady Mem Hosp Campus,Glenn Mem Bldg,Room 302,69, Atlanta, GA 30322 USA. EM ball.chad@gmail.com NR 56 TC 15 Z9 15 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2010 VL 69 IS 6 BP 1323 EP 1333 DI 10.1097/TA.0b013e3181f66878 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 695RT UT WOS:000285391000012 PM 21045742 ER PT J AU Perkins, JG AF Perkins, Jeremy G. TI Duration of Red Cell Storage Influences Mortality After Trauma EDITORIAL COMMENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Perkins, Jeremy G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Perkins, Jeremy G.] USA, LTC, Washington, DC 20310 USA. RP Perkins, JG (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2010 VL 69 IS 6 BP 1430 EP 1431 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 695RT UT WOS:000285391000033 ER PT J AU Prapasarakul, N Tummaruk, P Niyomtum, W Tripipat, T Serichantalergs, O AF Prapasarakul, Nuvee Tummaruk, Padet Niyomtum, Waree Tripipat, Titima Serichantalergs, Oralak TI Virulence Genes and Antimicrobial Susceptibilities of Hemolytic and Nonhemolytic Escherichia coli Isolated from Post-Weaning Piglets in Central Thailand SO JOURNAL OF VETERINARY MEDICAL SCIENCE LA English DT Article DE antimicrobial resistance; Escherchia coli; hemolysis; swine; virulence gene ID STRAINS; PIGS; ENTEROTOXINS; RESISTANCE; DIARRHEA; ETEC; PATHOGENICITY; PREVALENCE; PHENOTYPES; INFECTION AB The purpose of this study was to compare the existence of virulence genes in hemolytic Escherichia coli (HEC) and non-hemolytic E. coli (NHEC) isolated from weaner pigs in Thailand, and to determine their susceptibility to 10 antimicrobial agents. A total of 304 E. coli isolates were obtained from 90 piglets with diarrhea and 110 healthy piglets. Of these, 74 HEC isolates were obtained from 70 pies with diarrhea, and 4 were obtained from 4 healthy pigs, while 190 and 40 NHEC were recovered from 110 healthy and 20 pies with diarrhea, respectively. A ten digoxigenin (DIG)-labeled probe system was utilized for detecting genes encoding virulence-associated toxins and proteins in these isolates, and the minimal inhibitory concentration values against 10 antimicrobials were determined by means of the agar dilution technique. In total, 70.3% of the HEC isolates contained an exotoxin gene, lth, estp or stx2e, whereas 2.6% of the NHEC isolates hybridized with a gene probe for estp or stx2e. Over 90% of the isolates were resistant to most agents other than colistin and halquinol. The MIC(90) values of the HEC isolates for halquinol and colistin were 4 and 8 times greater than those of the NHEC isolates, respectively. The results represent the first characterization of resistant pathogenic E. coli distributed in the Thai pig industry. Amongst the HEC isolates, there appeared to be an association between the presence of some exotoxin genes, including lth, estp and stx2e, and reduced antimicrobial susceptibility. C1 [Prapasarakul, Nuvee; Niyomtum, Waree; Tripipat, Titima] Chulalongkorn Univ, Dept Vet Microbiol, Fac Vet Sci, Bangkok, Thailand. [Tummaruk, Padet] Chulalongkorn Univ, Dept Obstet Gynaecol & Reprod, Fac Vet Sci, Bangkok, Thailand. [Serichantalergs, Oralak] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. RP Prapasarakul, N (reprint author), Chulalongkorn Univ, Dept Vet Microbiol, Fac Vet Sci, Henri Dunang St, Bangkok, Thailand. EM Nuvee.P@chula.ac.th NR 42 TC 5 Z9 5 U1 2 U2 14 PU JAPAN SOC VET SCI PI TOKYO PA UNIV TOKYO, 1-1-1 YAYOI, BUNKYO-KU, TOKYO, 103, JAPAN SN 0916-7250 J9 J VET MED SCI JI J. Vet. Med. Sci. PD DEC PY 2010 VL 72 IS 12 BP 1603 EP 1608 DI 10.1292/jvms.10-0124 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 703NY UT WOS:000285986700011 PM 20689225 ER PT J AU Parker, MD Buckley, MJ Melanson, VR Glass, PJ Norwood, D Hart, MK AF Parker, Michael D. Buckley, Marilyn J. Melanson, Vanessa R. Glass, Pamela J. Norwood, David Hart, Mary Kate TI Antibody to the E3 Glycoprotein Protects Mice against Lethal Venezuelan Equine Encephalitis Virus Infection SO JOURNAL OF VIROLOGY LA English DT Article ID SEMLIKI-FOREST-VIRUS; SINDBIS-VIRUS; MONOCLONAL-ANTIBODIES; VACCINE CANDIDATE; MEMBRANE-PROTEINS; ENCEPHALOMYELITIS VIRUS; ATTENUATED VACCINES; E2 GLYCOPROTEIN; SPIKE PROTEIN; FUSION AB Six monoclonal antibodies were isolated that exhibited specificity for a furin cleavage site deletion mutant (V3526) of Venezuelan equine encephalitis virus (VEEV). These antibodies comprise a single competition group and bound the E3 glycoprotein of VEEV subtype I viruses but failed to bind the E3 glycoprotein of other alphaviruses. These antibodies neutralized V3526 virus infectivity but did not neutralize the parental strain of Trinidad donkey (TrD) VEEV. However, the E3-specific antibodies did inhibit the production of virus from VEEV TrD-infected cells. In addition, passive immunization of mice demonstrated that antibody to the E3 glycoprotein provided protection against lethal VEEV TrD challenge. This is the first recognition of a protective epitope in the E3 glycoprotein. Furthermore, these results indicate that E3 plays a critical role late in the morphogenesis of progeny virus after E3 appears on the surfaces of infected cells. C1 [Parker, Michael D.; Melanson, Vanessa R.; Glass, Pamela J.; Hart, Mary Kate] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Norwood, David] Diagnost Syst Div, Frederick, MD USA. [Buckley, Marilyn J.] Integrated Toxicol Div, Frederick, MD USA. [Hart, Mary Kate] DynPort Vaccine Co, Frederick, MD USA. RP Glass, PJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. EM pamela.glass@amedd.army.mil RI Glass, Pamela/G-1170-2011 NR 53 TC 15 Z9 15 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 2010 VL 84 IS 24 BP 12683 EP 12690 DI 10.1128/JVI.01345-10 PG 8 WC Virology SC Virology GA 683IN UT WOS:000284469600022 PM 20926570 ER PT J AU Zhou, J Enewold, L Peoples, GE Clifton, GT Potter, JF Stojadinovic, A Zhu, KM AF Zhou, Jing Enewold, Lindsey Peoples, George E. Clifton, Guy T. Potter, John F. Stojadinovic, Alexander Zhu, Kangmin TI Trends in Cancer Screening Among Hispanic and White Non-Hispanic Women, 2000-2005 SO JOURNAL OF WOMENS HEALTH LA English DT Article ID HEALTH INTERVIEW SURVEY; COLORECTAL-CANCER; BREAST-CANCER; UNITED-STATES; FAMILY-HISTORY; US WOMEN; MAMMOGRAPHY; DISPARITIES; POPULATION; PREDICTORS AB Background: Hispanics are the largest and fastest growing ethnic group in the United States. Compared with white non-Hispanic women, however, Hispanic women have significantly lower cancer screening rates. Programs designed to increase cancer screening rates, including the national Screen for Life campaign, which specifically promoted colorectal cancer (CRC) screening, regional educational/research programs, and state cancer control programs, have been launched. Screen for Life and some of these other intervention programs have targeted Hispanic populations by providing educational materials in Spanish in addition to English. Methods: The objective of this study was to compare changes in colorectal, breast, and cervical cancer screening rates from 2000 to 2005 among Hispanic and white non-Hispanic women, using data from the National Health Interview Survey (NHIS). The age ranges of study subjects and the definitions of cancer screening were site specific and based on the American Cancer Society (ACS) screening recommendations. Results: Although overall screening rates were found to be lower among Hispanic women, CRC screening increased about 1.5-fold among both Hispanic and white non-Hispanic women, mainly driven by endoscopic screening, which increased 2.1-fold and 2.9-fold, respectively, from 2000 to 2005 (p<0.01). Fecal occult blood testing (FOBT) for CRC declined among white non-Hispanic women and remained stable among Hispanic women during the same period. Mammogram and Pap smear screening tended to decline during the study period for both ethnic groups, especially white non-Hispanic women. Conclusion: Although cancer screening rates may be affected by multiple factors, culturally sensitive and linguistically appropriate national educational programs may have contributed to the increase in endoscopic CRC screening compliance. C1 [Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Peoples, George E.; Clifton, Guy T.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Potter, John F.; Stojadinovic, Alexander; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Zhu, KM (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite A-109,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kangmin.zhu@amedd.army.mil FU United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation FX This research was supported by the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 53 TC 11 Z9 11 U1 16 U2 20 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD DEC PY 2010 VL 19 IS 12 BP 2167 EP 2174 DI 10.1089/jwh.2009.1909 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 685KF UT WOS:000284626900005 PM 21039233 ER PT J AU Choi, KM Kim, JY Moon, SU Lee, HW Sattabongkot, J Na, BK Kim, DW Suh, EJ Kim, YJ Cho, SH Lee, HS Rhie, HG Kim, TS AF Choi, Kyung-Mi Kim, Jung-Yeon Moon, Sung-Ung Lee, Hyeong-Woo Sattabongkot, Jetsumon Na, Byoung-Kuk Kim, Dae-Won Suh, Eun-Jung Kim, Yeon-Joo Cho, Shin-Hyeong Lee, Ho-Sa Rhie, Ho-Gun Kim, Tong-Soo TI Molecular Cloning of Plasmodium vivax Calcium-Dependent Protein Kinase 4 SO KOREAN JOURNAL OF PARASITOLOGY LA English DT Article DE Plasmodium vivax; calcium-dependent protein kinase; schizont; EF-hand motif ID FALCIPARUM; PARASITES; RESOURCES; CELL AB A family of calcium-dependent protein kinases (CDPKs) is a unique enzyme which plays crucial roles in intracellular calcium signaling in plants, algae, and protozoa. CDPKs of malaria parasites are known to be key regulators for stage-specific cellular responses to calcium, a widespread secondary messenger that controls the progression of the parasite. In our study, we identified a gene encoding Plasmodium vivax CDPK4 (PvCDPK4) and characterized its molecular property and cellular localization. PvCDPK4 was a typical CDPK which had well-conserved N-terminal kinase domain and C-terminal calmodulin-like structure with 4-EF hand motifs for calcium-binding. The recombinant protein of EF hand domain of PvCDPK4 was expressed in Echerichia coli and a 34 kDa product was obtained. Immunofluorescence assay by confocal laser microscopy revealed that the protein was expressed at the mature schizont of P. vivax. The expression of PvCDPK4-EF in schizont suggests that it may participate in the proliferation or egress process in the life cycle of this parasite. C1 [Choi, Kyung-Mi; Kim, Jung-Yeon; Moon, Sung-Ung; Kim, Dae-Won; Suh, Eun-Jung; Kim, Yeon-Joo; Cho, Shin-Hyeong; Kim, Tong-Soo] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, Natl Inst Hlth, Seoul 122701, South Korea. [Lee, Hyeong-Woo] Univ Florida, Dept Pathol, Gainesville, FL 32610 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Na, Byoung-Kuk] Gyeongsang Natl Univ, Sch Med, Dept Parasitol, Jinju 660751, South Korea. [Na, Byoung-Kuk] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Jinju 660751, South Korea. [Choi, Kyung-Mi; Lee, Ho-Sa; Rhie, Ho-Gun] Kyung Hee Univ, Inst Global Environm, Seoul 130701, South Korea. [Choi, Kyung-Mi; Lee, Ho-Sa; Rhie, Ho-Gun] Kyung Hee Univ, Dept Biol, Seoul 130701, South Korea. [Kim, Tong-Soo] Inha Univ, Sch Med, Dept Parasitol, Inchon 400712, South Korea. RP Kim, TS (reprint author), Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, Natl Inst Hlth, Seoul 122701, South Korea. EM tongsookim@inha.ac.kr FU Korea National Institute of Health [KCDC 2006-N00238-00, 2007-N00320-00, 2008-N00410-00]; Korea Government (MEST) [2010-0004043] FX This study was supported by a grant from an intramural fund of the Korea National Institute of Health (KCDC 2006-N00238-00, 2007-N00320-00, 2008-N00410-00) and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) No. 2010-0004043. Anti-MSP mouse monoclonal antibody was kindly provided by Dr. Chom-Kyu Chong, Bioland, Cheongwon Research Institute, Korea. NR 17 TC 2 Z9 2 U1 0 U2 1 PU KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI PI SEOUL PA DEPT PARASITOLOGY, SEOUL, 00000, SOUTH KOREA SN 0023-4001 J9 KOREAN J PARASITOL JI Korean J. Parasitol. PD DEC PY 2010 VL 48 IS 4 BP 319 EP 324 DI 10.3347/kjp.2010.48.4.319 PG 6 WC Parasitology SC Parasitology GA 705SR UT WOS:000286158700008 PM 21234235 ER PT J AU Amos, CB Kelson, KI Rood, DH Simpson, DT Rose, RS AF Amos, Colin B. Kelson, Keith I. Rood, Dylan H. Simpson, David T. Rose, Ronn S. TI Late Quaternary slip rate on the Kern Canyon fault at Soda Spring, Tulare County, California SO LITHOSPHERE LA English DT Article ID SIERRA-NEVADA; COSMOGENIC RADIONUCLIDES; RANGE; SYSTEM; BE-10; BASIN; MUONS AB The Kern Canyon fault represents a major tectonic and physiographic boundary in the southern Sierra Nevada of east-central California. Previous investigations of the Kern Canyon fault underscore its importance as a Late Cretaceous and Neogene shear zone in the tectonic development of the southern Sierra Nevada. Study of the late Quaternary history of activity, however, has been confounded by the remote nature of the Kern Canyon fault and deep along-strike exhumation within the northern Kern River drainage, driven by focused fluvial and glacial erosion. Recent acquisition of airborne lidar (light detection and ranging) topography along the similar to 140 km length of the Kern Canyon fault provides a comprehensive view of the active surface trace. High-resolution, lidar-derived digital elevation models (DEMs) for the northern Kern Canyon fault enable identification of previously unrecognized offsets of late Quaternary moraines near Soda Spring (36.345 degrees N, 118.408 degrees W). Predominately north-striking fault scarps developed on the Soda Spring moraines display west-side-up displacement and lack a significant sense of strike-slip separation, consistent with detailed mapping and trenching along the entire Kern Canyon fault. Scarp-normal topographic profiling derived from the lidar DEMs suggests normal displacement of at least 2.8 +0.6/-0.5 m of the Tioga terminal moraine crest. Cosmogenic (10)Be exposure dating of Tioga moraine boulders yields a tight age cluster centered around 18.1 +/- 0.5 ka (n = 6), indicating a minimum normal-sense fault slip rate of similar to 0.1-0.2 mm/yr over this period. Taken together, these results provide the first clear documentation of late Quaternary activity on the Kern Canyon fault and highlight its role in accommodating internal deformation of the southern Sierra Nevada. C1 [Amos, Colin B.; Kelson, Keith I.] William Lettis & Associates Inc, Walnut Creek, CA 94596 USA. [Rood, Dylan H.] Lawrence Livermore Natl Lab, Ctr Accelerator Mass Spectrometry, Livermore, CA 94550 USA. [Rood, Dylan H.] Univ Calif Santa Barbara, Dept Earth Sci, Santa Barbara, CA 93106 USA. [Simpson, David T.] Urs Corp, Oakland, CA 94612 USA. [Rose, Ronn S.] US Army Corps Engineers, Dam Safety Assurance Program, Sacramento, CA 95814 USA. RP Amos, CB (reprint author), Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. RI Amos, Colin/B-2397-2008 OI Amos, Colin/0000-0002-3862-9344 FU U.S. Army Corps; U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX This research was supported by the Sacramento District of the U.S. Army Corps of Engineers, as part of the Dam Safety Assurance Program for Isabella Dam, under contract to the URS/Kleinfelder/Geomatrix Joint Venture. Dating analysis was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. Marco Ticci (William Lettis and Associates, Inc.) provided assistance with geographic information systems (GIS) analysis of the lidar data and digital mapping at Soda Spring. San Joaquin Helicopters of Delano, California, supported our field efforts in northern Kern Canyon. We thank Kurt Frankel for his review comments that substantially improved the manuscript. Hearty thanks go to the Kern Lodge and the Kern River Brewing Company for their hospitality during our stays in Kernville. NR 32 TC 9 Z9 9 U1 2 U2 7 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1941-8264 J9 LITHOSPHERE-US JI Lithosphere PD DEC PY 2010 VL 2 IS 6 BP 411 EP 417 DI 10.1130/L100.1 PG 7 WC Geochemistry & Geophysics; Geology SC Geochemistry & Geophysics; Geology GA 672BV UT WOS:000283558900002 ER PT J AU West, BJ Grigolini, P AF West, Bruce J. Grigolini, Paolo TI The Living Matter Way to exchange information SO MEDICAL HYPOTHESES LA English DT Article AB It is hypothesized that the special way information is exchanged between living networks, the Living Matter Way (LMW), is determined by the Principle of Complexity Matching, which asserts that the relative complexity of two complex networks determines the transfer of information between them. The LMW explains the neurophysiology of habituation and why classical music persists in your head long after the music stops. Published by Elsevier Ltd. C1 [West, Bruce J.] USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. EM bwest@nc.rr.com NR 22 TC 9 Z9 9 U1 2 U2 3 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD DEC PY 2010 VL 75 IS 6 BP 475 EP 478 DI 10.1016/j.mehy.2010.04.028 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 715VO UT WOS:000286918300001 PM 20493639 ER PT J AU Borch, FL AF Borch, Fred L., III TI THE SECRETS OF ABU GHRAIB REVEALED: AMERICAN SOLDIERS ON TRIAL SO MILITARY LAW REVIEW LA English DT Book Review C1 [Borch, Fred L., III] USA, Sch TJAGLCS, Charlottesville, VA USA. RP Borch, FL (reprint author), USA, Judge Advocate Gen Corp, Judge Advocate Gen Legal Ctr, Charlottesville, VA USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2010 VL 206 BP 188 EP 194 PG 7 WC Law SC Government & Law GA 801JP UT WOS:000293435100005 ER PT J AU Schnakenberg, MT AF Schnakenberg, Mark T. TI TORTURED: WHEN GOOD SOLDIERS DO BAD THINGS SO MILITARY LAW REVIEW LA English DT Book Review C1 [Schnakenberg, Mark T.] US Army, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2010 VL 206 BP 195 EP 203 PG 9 WC Law SC Government & Law GA 801JP UT WOS:000293435100006 ER PT J AU Hill, JT AF Hill, James T. TI WARRIOR KING: THE TRIUMPH AND BETRAYAL OF AN AMERICAN COMMANDER IN IRAQ SO MILITARY LAW REVIEW LA English DT Book Review C1 [Hill, James T.] USA, Washington, DC USA. RP Hill, JT (reprint author), 1st Armored Div, Ft Bliss, TX USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2010 VL 206 BP 204 EP 212 PG 9 WC Law SC Government & Law GA 801JP UT WOS:000293435100007 ER PT J AU Filliung, DR Bower, LM Hopkins-Chadwick, D Leggett, MK Bacsa, C Harris, K Steele, N AF Filliung, Dusty R. Bower, Lisa M. Hopkins-Chadwick, Denise Leggett, Melinda K. Bacsa, Christine Harris, Kurk Steele, Nancy TI Characteristics of Medical-Surgical Patients at the 86th Combat Support Hospital During Operation Iraqi Freedom SO MILITARY MEDICINE LA English DT Article ID US ARMY; PERSONNEL AB A descriptive study was performed of the U.S. and coalition forces patients admitted to the Intermediate Care Ward (ICW) of the 86th Combat Support Hospital (CSH) in Baghdad, Iraq (2007-2009). A prospective study was conducted of the patients admitted to the ward between April 12 and July 19, 2008. Three hundred and fifty three patients were included in the study. Characteristics of the patients admitted during a 3-month period of the deployment of the 86th CSH in Iraq, as well as the types of illnesses and injuries most commonly seen are reported. Implications for nurses preparing to deploy as well as implications for future research are discussed. C1 [Filliung, Dusty R.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Bower, Lisa M.; Hopkins-Chadwick, Denise] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Leggett, Melinda K.] Family Med Residency Ctr, Carl R Darnall Army Med Ctr, Ft Hood, TX 76544 USA. [Bacsa, Christine] ATTN MCXI DPM PH, Dept Prevent Med, Ft Hood, TX 76544 USA. [Harris, Kurk] MCXC DPM Ft Bragg, Womack Army Med Ctr, Dept Preventat Med, WAMC STOP A, Ft Bragg, NC 28310 USA. [Steele, Nancy] European Reg Med Command, APO, AE 09180 USA. RP Filliung, DR (reprint author), Univ Michigan, Sch Nursing, 400 N Ingalls, Ann Arbor, MI 48109 USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2010 VL 175 IS 12 BP 971 EP 977 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 691KO UT WOS:000285078900010 PM 21265304 ER PT J AU Crouch, HK Murray, CK Hospenthal, DR AF Crouch, Helen K. Murray, Clinton K. Hospenthal, Duane R. TI Development of a Deployment Infection Control Course SO MILITARY MEDICINE LA English DT Article ID MULTIDRUG-RESISTANT; CALCOACETICUS COMPLEX; CONTROL CHALLENGES; MILITARY; IRAQ; SUSCEPTIBILITY; REQUIREMENTS; OPERATIONS; FACILITIES; PERSONNEL AB Since the beginning of military operations in Iraq and Afghanistan, multidrug-resistant bacteria have been noted to be infecting and colonizing combat casualties. Studies suggest the primary source of these bacteria is nosocomial transmission. A focus area for improvement has been to enhance infection control (IC) at hospitals in the combat theater. A 5-day IC course was developed and implemented to provide just-in-time training to those personnel who have been identified to lead IC efforts while deployed. Twenty-nine students have attended the first 6 offerings of this course. A pre- and post-course test showed an average 21% improvement in knowledge. A follow-up questionnaire provided to those students who deployed found the course had enhanced performance of their IC duties. We describe the deployment-unique training developed to provide basic IC, emphasizing the unique challenges found in the combat setting. C1 [Crouch, Helen K.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Crouch, HK (reprint author), Brooke Army Med Ctr, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2010 VL 175 IS 12 BP 983 EP 989 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 691KO UT WOS:000285078900012 PM 21265306 ER PT J AU Andrews, AM Kantor, MA AF Andrews, Anne M. Kantor, Mark A. TI Oxidative Stress Increases in Overweight Individuals Following an Exercise Test SO MILITARY MEDICINE LA English DT Article ID ECCENTRIC EXERCISE; PHYSICAL-ACTIVITY; BIOMARKERS; ANTIOXIDANTS; WOMEN; MARKERS; HUMANS AB The objective of this study was to determine whether the Army Physical Fitness Test (APFT) causes oxidative stress and evaluate the impact of dietary antioxidant intake, fitness level, and body composition on changes in oxidative stress. Forty-seven overweight subjects were asked to perform an APFT. Creatine kinase (CK), C-reactive protein (CRP), glutathione peroxidase (GPX), and superoxide dismutase (SOD) were measured before, immediately after, and 24 hr postexercise. CK significantly increased immediately postexercise and at 24 hr postexercise. CRP and GPX significantly increased immediately postexercise, whereas SOD did not change significantly. Antioxidant intake, fitness level, and body composition were found to significantly influence changes in CK, GPX, and SOD after exercise. In conclusion, the APFT causes oxidative stress in overweight subjects. The associations between dietary antioxidants, fitness level, and body composition seen with each of the biomarkers provide support for future research in this area. C1 [Andrews, Anne M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kantor, Mark A.] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA. RP Andrews, AM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. FU Department of Clinical Investigation, Walter Reed Army Medical Center FX The authors thank the service members who volunteered for this study. Funding for this study was provided by the Department of Clinical Investigation, Walter Reed Army Medical Center. NR 21 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2010 VL 175 IS 12 BP 1014 EP 1019 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 691KO UT WOS:000285078900018 PM 21265312 ER PT J AU Stinner, DJ Burns, TC Kirk, KL Scoville, CR Ficke, JR Hsu, JR AF Stinner, Daniel J. Burns, Travis C. Kirk, Kevin L. Scoville, Charles R. Ficke, James R. Hsu, Joseph R. CA LAST TI Prevalence of Late Amputations During the Current Conflicts in Afghanistan and Iraq SO MILITARY MEDICINE LA English DT Article ID LOWER-EXTREMITY TRAUMA; LIMB SALVAGE; FRACTURES; AMPUTEE AB During the current conflicts, over 950 soldiers have sustained a combat-related amputation. The majority of these are acute, but an unknown number are performed months to years after the initial injury. The goal of this study is to determine the prevalence of late amputations in our combat wounded. Electronic medical records and radiographs of all soldiers who had a combat-related, lower extremity injury that resulted in amputation were reviewed to confirm demographic, injury, and amputation information. Time to amputation was defined as a late amputation when it occurred more than 12 weeks following the date of injury. There were 348 major limb amputees that met inclusion criteria. Fifty-three (1:5.2%) amputees had a late amputation (range = 12 wk-5.5 yr). While the majority of combat-related amputations occur acutely, more than 15% occur late. This study demonstrates that further research is needed to identify predictive factors and outcomes of the late amputation. C1 [Stinner, Daniel J.; Hsu, Joseph R.] US Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Stinner, Daniel J.; Burns, Travis C.; Kirk, Kevin L.; Ficke, James R.; Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Scoville, Charles R.; LAST] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Stinner, DJ (reprint author), US Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 15 TC 24 Z9 24 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2010 VL 175 IS 12 BP 1027 EP 1029 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 691KO UT WOS:000285078900020 PM 21265314 ER PT J AU Price, DB Rosse, RB Henry, JW Lenert, JJ Birk, AC AF Price, Douglas B. Rosse, Richard B. Henry, Joseph W. Lenert, Joanne J. Birk, Ann C. TI The Phantom Limb Experience and Sensory Phenomena in a Relocated Limb in a Case of Fillet Flap Used to Reconstruct a Massive Wound Proximal to an Above-Knee Amputation SO MILITARY MEDICINE LA English DT Article ID CORTICAL REORGANIZATION; PAIN; FOOT; SALVAGE; EXTREMITY; HEMIPELVECTOMY; PRESERVATION; PLASTICITY; AMPUTEES; PATIENT AB A 41-year-old male sustained a massive crushing injury to his left posterior thigh and buttock and transection of the sciatic nerve; he underwent an above-knee amputation with fillet flap. He was interviewed 24 months post-operatively to determine his phantom limb experience. At 37 and 42 months, testing for touch-pressure sensitivity of the residual limb and buttock was done with a 1-gram monofilament. Results: (1) He described a typical phantom limb with some unusual features. (2) Stimulation of points on transposed and original skin were located accurately or roughly according to normal anatomy, were mislocated, or felt simultaneously at the point stimulated and another place, i.e., bilocations. It It is hypothesized that such mislocations and bilocations represented clinical correlates of cortical somatosensory reorganization. It is not clear why a typical phantom limb could occur when there was only partial deafferentation of the limb. Further studies are recommended. C1 [Price, Douglas B.; Rosse, Richard B.; Henry, Joseph W.] Dept Vet Affairs Med Ctr, Washington, DC 20422 USA. [Lenert, Joanne J.] George Washington Univ Hosp, Dept Surg, Washington, DC 20037 USA. [Birk, Ann C.] Walter Reed Army Med Ctr, Bethesda, MD 20817 USA. RP Price, DB (reprint author), Dept Vet Affairs Med Ctr, 50 Irving St NW, Washington, DC 20422 USA. NR 47 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2010 VL 175 IS 12 BP 1030 EP 1036 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 691KO UT WOS:000285078900021 PM 21265315 ER PT J AU Spurgers, KB Alefantis, T Peyser, BD Ruthel, GT Bergeron, AA Costantino, JA Enterlein, S Kota, KP Boltz, RCD Aman, MJ DelVecchio, VG Bavari, S AF Spurgers, Kevin B. Alefantis, Tim Peyser, Brian D. Ruthel, Gordon T. Bergeron, Alison A. Costantino, Julie A. Enterlein, Sven Kota, Krishna P. Boltz, R. C. Dutch Aman, M. Javad DelVecchio, Vito G. Bavari, Sina TI Identification of Essential Filovirion-associated Host Factors by Serial Proteomic Analysis and RNAi Screen SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID EBOLA-VIRUS VP24; PROTEIN-SORTING PATHWAY; ENVELOPE PROTEIN; MATRIX PROTEIN; MARBURG-VIRUS; RIBOSOMAL-PROTEINS; VP40 PROTEIN; VP35 PROTEIN; IN-VIVO; CELLS AB An assessment of the total protein composition of filovirus (ebolavirus and marburgvirus) virions is currently lacking. In this study, liquid chromatography-linked tandem mass spectrometry of purified ebola and marburg virions was performed to identify associated cellular proteins. Host proteins involved in cell adhesion, cytoskeleton, cell signaling, intracellular trafficking, membrane organization, and chaperones were identified. Significant overlap exists between this data set and proteomic studies of disparate viruses, including HIV-1 and influenza A, generated in multiple cell types. However, the great majority of proteins identified here have not been previously described to be incorporated within filovirus particles. Host proteins identified by liquid chromatography-linked tandem mass spectrometry could lack biological relevance because they represent protein contaminants in the virus preparation, or because they are incorporated within virions by chance. These issues were addressed using siRNA library-mediated gene knockdown (targeting each identified virion-associated host protein), followed by filovirus infection. Knockdown of several host proteins (e. g. HSPA5 and RPL18) significantly interfered with ebolavirus and marburgvirus infection, suggesting specific and relevant virion incorporation. Notably, select siRNAs inhibited ebolavirus, but enhanced marburgvirus infection, suggesting important differences between the two viruses. The proteomic analysis presented here contributes to a greater understanding of filovirus biology and potentially identifies host factors that can be targeted for antiviral drug development. Molecular & Cellular Proteomics 9: 2690-2703, 2010. C1 [Spurgers, Kevin B.; Peyser, Brian D.; Ruthel, Gordon T.; Bergeron, Alison A.; Costantino, Julie A.; Enterlein, Sven; Aman, M. Javad; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Alefantis, Tim; DelVecchio, Vito G.] Vital Probes Inc, Mayfield, PA 18433 USA. [Enterlein, Sven; Aman, M. Javad] Perkin Elmer, Waltham, MA 02451 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil OI Peyser, Brian/0000-0002-3455-5181 FU Defense Threat Reduction Agency [44.10022-08-RD-B, 0048-09-RD-T] FX A portion of the research described herein was sponsored by the Defense Threat Reduction Agency (JSTO-CBD project number 44.10022-08-RD-B and TMTI project number 0048-09-RD-T). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. During a portion of this research, KBS was appointed to the Postgraduate Research Participation Program administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U. S. Department of Energy and USAMRMC. NR 76 TC 30 Z9 30 U1 0 U2 9 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD DEC PY 2010 VL 9 IS 12 BP 2690 EP 2703 DI 10.1074/mcp.M110.003418 PG 14 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 688VJ UT WOS:000284882100010 PM 20702783 ER PT J AU Teja-Isavadharm, P Siriyanonda, D Siripokasupkul, R Apinan, R Chanarat, N Lim, A Wannaying, S Saunders, D Fukuda, MM Miller, RS Weina, PJ Melendez, V AF Teja-Isavadharm, Paktiya Siriyanonda, Duangsuda Siripokasupkul, Raveewan Apinan, Roongnapa Chanarat, Nitima Lim, Apassorn Wannaying, Srisombat Saunders, David Fukuda, Mark M. Miller, Robert S. Weina, Peter J. Melendez, Victor TI A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma SO MOLECULES LA English DT Article DE artesunate; dihydroartemisinin; human plasma; method validation; LC-MS ID SEVERE FALCIPARUM-MALARIA; ARTEMISININ; DERIVATIVES; VALIDATION; EXTRACTION; COMBINATION AB Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in human (heparinized) plasma based on one-step protein precipitation in acetonitrile using artemisinin (ARN) as an internal standard, followed by liquid chromatography with a single quadrupole mass spectrometry system connected to a C(18) column. Peak area ratio responses were fitted to the 2(nd)-order curve type, polynomial equation with weighting (1/concentration) over a quantification range between 3.20/5.33-3,000/5,000 nM (1.23/1.52-1153/1422 ng/mL) of AS/DHA showing linearity with very good correlation (r(2) > 0.999). Single ion recordings of 5 mu L injections of plasma extracts allowed for limits of detection of 1.02 nM (0.39 ng/mL) for AS and 0.44 nM (0.13 ng/mL) for DHA. The inter-assay and intra-assay accuracy and precision of the method was very good with an inaccuracy of +/- 12.4% and coefficients of variation of <= 10.7% at all tested concentrations. The recovery of the analytes from plasma was >= 95%. Other commonly used antimalarials including mefloquine, quinine, and chloroquine, did not interfere with the analysis. Post-preparative tests over 24 h in an autosampler (10 degrees C) showed that the DHA response was only 2.1% of AS from auto-hydrolysis, and beta-DHA was the major, stable epimer that was used for quantification of DHA. In contrast, alpha-DHA increased steadily up to 600%. Artesunate and DHA in plasma were stable through three freeze/thaw cycles for up to 6 h at room temperature and up to one year at -80 degrees C. C1 [Teja-Isavadharm, Paktiya; Siriyanonda, Duangsuda; Siripokasupkul, Raveewan; Apinan, Roongnapa; Chanarat, Nitima; Lim, Apassorn; Wannaying, Srisombat; Saunders, David; Fukuda, Mark M.; Melendez, Victor] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Miller, Robert S.; Weina, Peter J.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, Silver Spring, MD 20910 USA. RP Teja-Isavadharm, P (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM paktiyat@afrims.org; Robert.s.miller@amedd.army.mil; peter.weina@us.army.mil FU U.S. Army Medical Research and Materiel Command FX This study was supported by The U.S. Army Medical Research and Materiel Command. We thank LTC Shon Remich and LTC Mark Polhemus for the use of samples from their research protocol, and Anneke Engering for assisting in the preparation of this manuscript. NR 21 TC 10 Z9 10 U1 0 U2 13 PU MDPI AG PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1420-3049 J9 MOLECULES JI Molecules PD DEC PY 2010 VL 15 IS 12 BP 8747 EP 8768 DI 10.3390/molecules15128747 PG 22 WC Chemistry, Organic SC Chemistry GA 700CD UT WOS:000285709000015 PM 21124272 ER PT J AU Sloan, SD Harris, JB AF Sloan, Steven D. Harris, James B. TI Shallow seismic investigation of surface deformation associated with the Kilmichael dome, Montgomery County, Mississippi, USA SO NEAR SURFACE GEOPHYSICS LA English DT Article AB The Kilmichael dome structure is a circular feature exposed in unconsolidated early Tertiary sediments of north-central Mississippi, USA. The structural complexity of the area, including zones of intense faulting and uplifted strata, has led to several suggested origins for the formation of the Kilmichael dome, including meteorite impact and regional tectonics; however, the origin remains unknown. As part of an undergraduate student research project, we acquired shallow shear-wave seismic reflection data over a complex zone of surface faults on the northern flank of the Kilmichael dome, with the goal of imaging the subsurface expression of deformation associated with faulting expressed along an exposed road cut. We also collected multi-component downhole seismic data in a nearby borehole to analyse the shear-wave velocity structure of the shallow sediments and observe possible anisotropy. Polarization analysis of the downhole data identified shear-wave anisotropy consistent with structural alignments in the area. Interpretation of the reflection profile and particle motion plots from the downhole data allowed correlation with shallow structural features of the Kilmichael dome. C1 [Sloan, Steven D.] USA, Engineer Res & Dev Ctr, CEERD GS S, Vicksburg, MS 39180 USA. [Harris, James B.] Millsaps Coll, Dept Geol, Jackson, MS 39210 USA. RP Sloan, SD (reprint author), USA, Engineer Res & Dev Ctr, CEERD GS S, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM steven.d.sloan@usace.army.mil FU Gulf Coast Association of Geological Societies; Geotechnical and Structures Laboratory, US Army Engineer Research & Development Center FX The authors thank the Gulf Coast Association of Geological Societies for financial support of this study through an undergraduate research grant and Steve Ingram for field assistance and knowledge of the study area. Permission to publish this paper was granted by Director, Geotechnical and Structures Laboratory, US Army Engineer Research & Development Center. NR 14 TC 0 Z9 0 U1 0 U2 3 PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS PI 3990 DB, HOUTEN PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS SN 1569-4445 J9 NEAR SURF GEOPHYS JI Near Surf. Geophys. PD DEC PY 2010 VL 8 IS 6 SI SI BP 451 EP 457 DI 10.3997/1873-0604.2010046 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 695UX UT WOS:000285399200003 ER PT J AU Theeler, BJ Krasnokutsky, MV Scott, BR AF Theeler, Brett J. Krasnokutsky, Michael V. Scott, Beverly R. TI Exertional reversible cerebral vasoconstriction responsive to verapamil SO NEUROLOGICAL SCIENCES LA English DT Article DE Reversible cerebral vasoconstriction syndrome; Exertional headache; Orgasmic headache; Secondary headache disorders ID ORGASMIC HEADACHE; VASOSPASM AB We present a case of a 25-year-old male with severe headaches associated with exertion and sexual intercourse with vasoconstriction on magnetic resonance and CT angiograms done during his typical headaches. The headache syndrome and angiographic findings resolved after starting low-dose verapamil. Perhaps, some cases of primary exertional and primary headaches associated with sexual activity are associated with reversible cerebral vasoconstriction responsive to calcium channel blockers. C1 [Theeler, Brett J.] USA, Dept Med, Neurol Serv, William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Krasnokutsky, Michael V.] USA, Dept Radiol, Madigan Army Med Ctr, Ft Lewis, WA USA. [Scott, Beverly R.] USA, Dept Med, Neurol Serv, Madigan Army Med Ctr, Ft Lewis, WA USA. RP Theeler, BJ (reprint author), USA, Dept Med, Neurol Serv, William Beaumont Army Med Ctr, 5005 N Piedras, El Paso, TX 79920 USA. EM btheeler@hotmail.com NR 11 TC 7 Z9 9 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1590-1874 J9 NEUROL SCI JI Neurol. Sci. PD DEC PY 2010 VL 31 IS 6 BP 773 EP 775 DI 10.1007/s10072-010-0226-4 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 687BL UT WOS:000284748700013 PM 20182897 ER PT J AU Angoa-Perez, M Kreipke, CW Thomas, DM Van Shura, KE Lyman, M McDonough, JH Kuhn, DM AF Angoa-Perez, Mariana Kreipke, Christian W. Thomas, David M. Van Shura, Kerry E. Lyman, Megan McDonough, John H. Kuhn, Donald M. TI Soman increases neuronal COX-2 levels: Possible link between seizures and protracted neuronal damage SO NEUROTOXICOLOGY LA English DT Article DE Soman; COX-2; Neurons; Microglia; Astrocytes; Neurodegeneration ID METHAMPHETAMINE-INDUCED NEUROTOXICITY; LONG-TERM CONSEQUENCES; AGENT-INDUCED SEIZURES; ANTICONVULSANT TREATMENT; INDUCED NEUROPATHOLOGY; GLUTAMATE RELEASE; CARDIAC PATHOLOGY; TOKYO SUBWAY; SARIN; BRAIN AB Nerve agent-induced seizures cause neuronal damage in brain limbic and cortical circuits leading to persistent behavioral and cognitive deficits. Without aggressive anticholinergic and benzodiazepine therapy, seizures can be prolonged and neuronal damage progresses for extended periods of time. The objective of this study was to determine the effects of the nerve agent soman on expression of cyclooxygenase-2 (COX-2), the initial enzyme in the biosynthetic pathway of the proinflammatory prostaglandins and a factor that has been implicated in seizure initiation and propagation. Rats were exposed to a toxic dose of soman and scored behaviorally for seizure intensity. Expression of COX-2 was determined throughout brain from 4 h to 7 days after exposure by immunohistochemistry and immunoblotting. Microglial activation and astrogliosis were assessed microscopically over the same time-course. Soman increased COX-2 expression in brain regions known to be damaged by nerve agents (e.g., hippocampus, amygdala, piriform cortex and thalamus). COX-2 expression was induced in neurons, and not in microglia or astrocytes, and remained elevated through 7 days. The magnitude of COX-2 induction was correlated with seizure intensity. COX-1 expression was not changed by soman. Increased expression of neuronal COX-2 by soman is a late-developing response relative to other signs of acute physiological distress caused by nerve agents. COX-2-mediated production of prostaglandins is a consequence of the seizure-induced neuronal damage, even after survival of the initial cholinergic crisis is assured. COX-2 inhibitors should be considered as adjunct therapy in nerve agent poisoning to minimize nerve agent-induced seizure activity. Published by Elsevier Inc. C1 [Angoa-Perez, Mariana; Kuhn, Donald M.] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48202 USA. [Angoa-Perez, Mariana; Kreipke, Christian W.; Thomas, David M.; Kuhn, Donald M.] John D Dingell VA Med Ctr, Res & Dev Serv, Detroit, MI USA. [Kreipke, Christian W.] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA. [Thomas, David M.] Wayne State Univ, Dept Pharmaceut Sci, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI USA. [Van Shura, Kerry E.; Lyman, Megan; McDonough, John H.] USA, Pharmacol Branch, Div Res, Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Kuhn, DM (reprint author), Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48202 USA. EM donald.kuhn@wayne.edu FU Defense Threat Reduction Agency; NIH; Department of Veterans Affairs FX This work was supported by grants from the Defense Threat Reduction Agency, NIH and the Department of Veterans Affairs. Its contents are solely the responsibility of the authors and do not necessarily reflect the official views of the federal government. NR 43 TC 18 Z9 21 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2010 VL 31 IS 6 BP 738 EP 746 DI 10.1016/j.neuro.2010.06.007 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 679ZR UT WOS:000284199800015 PM 20600289 ER PT J AU Sniezek, JC Sofferman, RA AF Sniezek, Joseph C. Sofferman, Robert A. TI Head and Neck Ultrasound Preface SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 [Sniezek, Joseph C.] Tripler Army Med Ctr, MCHK DSH, Honolulu, HI 96859 USA. [Sniezek, Joseph C.] Univ Hawaii, John A Burns Sch Med, Dept Surg, Honolulu, HI 96813 USA. [Sofferman, Robert A.] Univ Vermont, Div Otolaryngol, Sch Med, Fletcher Allen Hlth Care, Burlington, VT 05401 USA. RP Sniezek, JC (reprint author), Tripler Army Med Ctr, MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM joseph.sniezek@us.army.mil; robert.sofferman@vtmednet.org NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2010 VL 43 IS 6 BP IX EP X DI 10.1016/j.otc.2010.09.001 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 683WD UT WOS:000284507400001 PM 21044731 ER PT J AU Sniezek, JC AF Sniezek, Joseph C. TI Head and Neck Ultrasound: Why Now? SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Ultrasound; Head; Neck; Ultrasound-guided procedures ID SURGEON-PERFORMED ULTRASOUND; THYROID-NODULES; ULTRASONOGRAPHY; MANAGEMENT; ABSCESSES; FEATURES; BENIGN; RISK AB This article provides an overview of ultrasound and the techniques for its use by otolaryngologists in diagnosing and treating neck masses and lesions. Head and neck ultrasound is extremely useful in diagnosing neck masses and lesions and in facilitating many procedures that are commonly performed on the head and neck. Although in the past these studies were generally performed by radiologists, clinicians are now able to perform high-quality ultrasound studies and ultrasound-guided procedures in the head and neck. Given the advanced knowledge of head and neck anatomy and disease processes that otolaryngologists possess, head and neck ultrasound offers a logical and valuable extension of the physical examination. Recent improvements in ultrasound resolution, portability, and affordability have provided an excellent impetus for otolaryngologists to incorporate ultrasound into their office and operative practices. C1 [Sniezek, Joseph C.] Tripler Army Med Ctr, MCHK DSH, Honolulu, HI 96859 USA. [Sniezek, Joseph C.] Univ Hawaii, Dept Surg, John A Burns Sch Med, Honolulu, HI 96813 USA. RP Sniezek, JC (reprint author), Tripler Army Med Ctr, MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM joseph.sniezek@us.army.mil FU AMEDD Advancements in Medical Technology Initiative (AAMTI) FX This work was supported by a grant from the AMEDD Advancements in Medical Technology Initiative (AAMTI). NR 12 TC 7 Z9 7 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2010 VL 43 IS 6 BP 1143 EP + DI 10.1016/j.otc.2010.08.001 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 683WD UT WOS:000284507400002 PM 21044732 ER PT J AU Klem, C AF Klem, Christopher TI Head and Neck Anatomy and Ultrasound Correlation SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Ultrasound; Head and neck; Normal anatomy ID TRACHEOSTOMY AB Thorough knowledge of the complex anatomy of the head and neck is essential to understanding the ultrasonographic appearance of this region. The intimate familiarity with anatomic structures obtained by performing surgical procedures makes active radiographic imaging modalities like ultrasound especially suited for use by surgeons. An understanding of the normal sonographic appearance of head and neck structures is critical to recognizing abnormal pathology. C1 Otolaryngol Head & Neck Surg Serv, Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Klem, C (reprint author), Otolaryngol Head & Neck Surg Serv, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christopher.klem@us.army.mil NR 8 TC 5 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2010 VL 43 IS 6 BP 1161 EP + DI 10.1016/j.otc.2010.08.005 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 683WD UT WOS:000284507400004 PM 21044734 ER PT J AU Rooks, VJ Cable, BB AF Rooks, Veronica J. Cable, Benjamin B. TI Head and Neck Ultrasound in the Pediatric Population SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Pediatric; Head and neck ultrasound; Otolaryngology; Office imaging ID ABSCESSES; CHILDREN AB Ultrasound, as a diagnostic modality, has been developing rapidly. High-resolution ultrasound machines have been reduced to the size of a laptop computer. Ultrasound can be adopted by otolaryngologists for use within the clinic and the operating room. Ultrasound offers several advantages to the pediatric patient population. It is well tolerated and adds a degree of precision to the physical examination. It can be done repeatedly as lesions evolve one treatment is performed. It is valuable for guidance and therapeutic treatment of lesions in the operating room. It is likely that ultrasound use will continue to rapidly grow and evolve as a tool within the field of otolaryngology. C1 [Rooks, Veronica J.; Cable, Benjamin B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Rooks, Veronica J.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Cable, Benjamin B.] Tripler Army Med Ctr, TAMC, Honolulu, HI 96859 USA. RP Cable, BB (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM benjamin.cable@us.army.mil NR 13 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2010 VL 43 IS 6 BP 1255 EP + DI 10.1016/j.otc.2010.08.010 PG 14 WC Otorhinolaryngology SC Otorhinolaryngology GA 683WD UT WOS:000284507400010 PM 21044740 ER PT J AU Holtel, MR AF Holtel, Michael R. TI Emerging Technology in Head and Neck Ultrasonography SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Ultrasound technology; Microbubbles; Ultrasound hemostasis; Head and neck ultrasound; Elastography ID INTENSITY FOCUSED ULTRASOUND; MALIGNANT THYROID-NODULES; DIFFERENTIAL-DIAGNOSIS; US-ELASTOGRAPHY; TIME; VISUALIZATION; BENIGN AB Increased use of ultrasonography of the head and neck by clinicians has resulted from more compact, higher resolution ultrasound machines that can be more readily used in the office setting. Palm-sized machines are already used for vascular access and bladder assessment. As the resolution of these machines becomes adequate for head and neck assessment, ultrasonography is likely to become a routine adjunct to the office physical examination. Further techniques to reduce artifact beyond spatial compounding, second harmonics, and broadband inversion techniques are likely to be developed to improve ultrasound images. Manual palpation using the ultrasound transducer or "sound palpation," using sound to recreate vibration provides information on tissue "stiffness," which has been successfully used to distinguish between benign and malignant lesions in the head and neck (particularly thyroid nodules). Microbubble contrast-enhanced ultrasound provides improved resolution of ultrasound images. Three- and four-dimensional ultrasonography provides for more accurate diagnosis. The ability of microbubbles with ligands affixed to their outer surface to target specific tissue makes them excellent delivery vehicles. DNA plasmids, chemotherapy agents, and therapeutic drugs can be released at a specific anatomic site. The motion of microbubbles stimulated by ultrasound can be used to increase drug penetration through tissues and has been shown to be effective in breaking up clots in stroke patients (without increased risk). High-intensity focused ultrasound can be used to create coagulation necrosis without significant damage to adjacent tissue. It has been effectively used in neurosurgery and urology, but its effectiveness in the head and neck is still being determined. A prototype for surgical navigation with ultrasound has been developed for the head and neck, which allows real-time imaging of anatomic surgical changes. C1 [Holtel, Michael R.] Univ Hawaii, Telemed Res Inst, Honolulu, HI 96813 USA. [Holtel, Michael R.] USA, Telemed & Adv Technol Res Ctr, Med Readiness & Mat Command, Ft Detrick, MD 21702 USA. RP Holtel, MR (reprint author), Sharp Rees Stealy Med Grp, 10670 Wexford St, San Diego, CA 92131 USA. EM mholtel@gmail.com NR 26 TC 3 Z9 4 U1 1 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2010 VL 43 IS 6 BP 1267 EP + DI 10.1016/j.otc.2010.08.003 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 683WD UT WOS:000284507400011 PM 21044741 ER PT J AU Shogan, PJ Monson, M AF Shogan, Paul J. Monson, Matthew TI Enlarged sella of primary childhood hypothyroidism SO PEDIATRIC RADIOLOGY LA English DT Editorial Material C1 [Shogan, Paul J.; Monson, Matthew] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Monson, M (reprint author), Walter Reed Army Med Ctr, Dept Radiol, BLDG 2,Rm 1X,6900 Georgia Ave NW, Washington, DC 20307 USA. EM matthew.monson@amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD DEC PY 2010 VL 40 SU 1 BP 163 EP 163 DI 10.1007/s00247-010-1561-6 PG 1 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA 692KZ UT WOS:000285153000082 ER PT J AU Gorman, GH Eide, M Hisle-Gorman, E AF Gorman, Gregory H. Eide, Matilda Hisle-Gorman, Elizabeth TI Wartime Military Deployment and Increased Pediatric Mental and Behavioral Health Complaints SO PEDIATRICS LA English DT Article DE military; deployment; pediatric mental health; behavior ID PARENTAL SEPARATION; DESERT-STORM; DEPRESSIVE SYMPTOMS; YOUNG-CHILDREN; MATERNAL DEPRESSION; EMOTIONAL-PROBLEMS; FAMILIES; IMPACT; SERVICES; STRESS AB BACKGROUND: Children of military personnel face stress when a parent deploys. OBJECTIVE: Our goal was to determine the effect of parental military deployment on the relative rate of outpatient visits for mental and behavioral health disorders in children aged 3 to 8 years. METHODS: This was a retrospective cohort study. Records of children of active-duty personnel during fiscal years 2006 and 2007 were linked with their parent's deployment records. Mental and behavioral health visits were identified by using International Classification of Diseases, Ninth Revision, codes. The incidence rate ratio (IRR) of visits per year according to parental deployment status was determined with random-effects negative binomial regression modeling with longitudinal data analysis. RESULTS: A total of 642 397 children aged 3 to 8 years and 442 722 military parents were included. Mean child age was 5.0 years (SD: 1.9 years); 50.6% were male, and 68.0% were white. Ninety percent of the parents were male, and 90.5% were married; 32.0% of the parents were deployed during the study. There were 1 049 081 person-years with 611 115 mental and behavioral health visits (0.6 visit per year). The IRR of mental and behavioral health visits for children with a deployed parent compared with when a parent was home was 1.11 (95% confidence interval [CI]: 1.07-1.14; P < .001). IRRs of pediatric anxiety, behavioral, and stress disorders when a parent deployed were 1.14 (95% CI: 0.98-1.32; P = .095), 1.19 (95% CI: 1.07-1.32; P < .001), and 1.18 (95% CI: 1.10-1.26; P < .001), respectively. Older children and children with military fathers and married parents had larger increases in rates of mental and behavioral health visits during parental deployments. In contrast, the overall outpatient rate and rates of visits for other diagnoses decreased when a parent was deployed. CONCLUSIONS: Mental and behavioral health visits increased by 11% in these children when a military parent deployed; behavioral disorders increased 19% and stress disorders increased 18%. Rates especially increased in older children and children of married and male military parents. Pediatrics 2010;126:1058-1066 C1 [Gorman, Gregory H.; Eide, Matilda] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Gorman, Gregory H.] Walter Reed Army Med Ctr, Sect Pediat Nephrol, Bethesda, MD USA. [Gorman, Gregory H.] Natl Naval Med Ctr, Bethesda, MD USA. [Hisle-Gorman, Elizabeth] Univ Maryland Baltimore, Sch Social Work, Baltimore, MD USA. RP Gorman, GH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM ggorman@usuhs.mil NR 46 TC 52 Z9 52 U1 5 U2 18 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 2010 VL 126 IS 6 BP 1058 EP 1066 DI 10.1542/peds.2009-2856 PG 9 WC Pediatrics SC Pediatrics GA 688EF UT WOS:000284831900030 PM 21059715 ER PT J AU Davis, BE AF Davis, Beth Ellen TI Parental Wartime Deployment and the Use of Mental Health Services Among Young Military Children SO PEDIATRICS LA English DT Editorial Material ID COMPONENT; FAMILIES; COMBAT; IRAQ; WAR C1 [Davis, Beth Ellen] Amer Acad Pediat, Sect Uniformed Serv, Elk Grove Village, IL USA. [Davis, Beth Ellen] USA, Med Corps, Washington, DC USA. RP Davis, BE (reprint author), Madigan Army Med Ctr, Dept Pediat, MCHJ PPS, Tacoma, WA 98431 USA. EM bethellen.davis@amedd.army.mil NR 9 TC 5 Z9 5 U1 1 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 2010 VL 126 IS 6 BP 1215 EP 1216 DI 10.1542/peds.2010-2543 PG 2 WC Pediatrics SC Pediatrics GA 688EF UT WOS:000284831900047 PM 21059724 ER PT J AU Ciezak, JA AF Ciezak, Jennifer A. TI The High-Pressure Characterization of Energetic Materials 2-Methyl-5-Nitramino-2H-Tetrazole SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE 2 Methyl 5 Nitramino 2H Tetrazole; Diamond Anvil Cell; Energetic Material; High Nitrogen Material; High Pressure ID VIBRATIONAL SPECTROSCOPY; THERMAL-DECOMPOSITION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; 5-NITRAMINOTETRAZOLE; SALTS AB The isothermal structural properties equation of state and vibrational dynamics of 2MNT were studied under high pressure using synchrotron XRD and optical Raman and IR microspectroscopy Analysis of the XRD patterns revealed no indication of a phase transition to near 15 GPa and the pressure volume isotherm remained smooth to 15 GPa Near 15 GPa significant sample damage was observed from the X ray beam which precluded the acquisition of patterns above this pressure XRD and Raman spectroscopic measurements showed the monoclinic ambient condition phase of 2MNT remains the dominant phase to near 20 GPa although a shift of the NO(2) IR active vibrational modes to lower frequencies suggested a subtle geometry modification not reflected in the XRD data C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. FU US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE AC02 98CH10886] FX Thanks are due to Dr Jingzhu Hu and Dr Zhenxian Liu of BNL for their technical assistance Use of the National Synchrotron Light Source Brookhaven National Laboratory, was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences under Contract no DE AC02 98CH10886 Special thanks are due to the Geophysical Laboratory of the Carnegie Institution of Washington for use of their Raman systems and sample loading facilities NR 20 TC 4 Z9 4 U1 1 U2 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD DEC PY 2010 VL 35 IS 6 BP 550 EP 554 DI 10.1002/prep.200910071 PG 5 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 702LZ UT WOS:000285897500007 ER PT J AU Hawksworth, D Ravindranath, L Chen, Y Furusato, B Sesterhenn, IA McLeod, DG Srivastava, S Petrovics, G AF Hawksworth, D. Ravindranath, L. Chen, Y. Furusato, B. Sesterhenn, I. A. McLeod, D. G. Srivastava, S. Petrovics, G. TI Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE C-MYC oncogene; quantitative expression; recurrence ID IN-SITU HYBRIDIZATION; CHROMOSOMAL-ANOMALIES; EXPRESSION; AMPLIFICATION; CARCINOMA; CARCINOGENESIS AB Alterations of chromosome 8, including amplification at 8q24 harboring the C-MYC oncogene, have been noted as one of the most common chromosomal abnormalities in prostate cancer (CaP) progression. However, the frequency of C-MYC alterations in CaP has remained uncertain. A recent study, using a new anti-MYC antibody, described prevalent upregulation of nuclear C-MYC protein expression as an early oncogenic alteration in CaP. Further, we have recently reported regulation of C-MYC expression by ERG and a significant correlation between C-MYC overexpression and TMPRSS2-ERG fusion in early stage CaP. These emerging data suggest that increased C-MYC expression may be a critical and early oncogenic event driving CaP progression. In this study, we assessed whether C-MYC mRNA overexpression in primary prostate tumors was predictive of more aggressive tumor or disease progression. Our approach was to quantitatively determine C-MYC mRNA expression levels in laser capture micro-dissected tumor cells and matched benign epithelial cells in a radical prostatectomy cohort with long follow-up data available. On the basis of our results, we conclude that elevated C-MYC expression in primary prostate tumor is biologically relevant and may be a predictor of future biochemical recurrence. Prostate Cancer and Prostatic Diseases (2010) 13, 311-315; doi: 10.1038/pcan.2010.31; published online 7 September 2010 C1 [Ravindranath, L.; Chen, Y.; McLeod, D. G.; Srivastava, S.; Petrovics, G.] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. [Hawksworth, D.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. RP Petrovics, G (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA. EM gpetrovics@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 FU National Institutes of Health [5R01 DK065977] FX This work was supported in part by Grant 5R01 DK065977 for SS and GP from the National Institutes of Health. We thank Dennis Young for her superb assistance with immunohistochemistry experiments. NR 24 TC 49 Z9 50 U1 0 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD DEC PY 2010 VL 13 IS 4 BP 311 EP 315 DI 10.1038/pcan.2010.31 PG 5 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 678UY UT WOS:000284108300004 PM 20820186 ER PT J AU Collamer, AN Battafarano, DF AF Collamer, Angelique N. Battafarano, Daniel F. TI Psoriatic Skin Lesions Induced by Tumor Necrosis Factor Antagonist Therapy: Clinical Features and Possible Immunopathogenesis SO SEMINARS IN ARTHRITIS AND RHEUMATISM LA English DT Review DE tumor necrosis factor; TNF; anti-TNF drugs; psoriasis; palmoplantar ID FACTOR-ALPHA THERAPY; NEW-ONSET PSORIASIS; TNF-ALPHA; RHEUMATOID-ARTHRITIS; CROHNS-DISEASE; PALMOPLANTAR PUSTULOSIS; CUTANEOUS MANIFESTATIONS; CASE SERIES; INFLIXIMAB TREATMENT; FLEXURAL PSORIASIS AB Objective: The induction or exacerbation of psoriasis in patients treated with tumor necrosis factor (TNF) antagonists is a well-established phenomenon. The goals of this comprehensive literature analysis were to update currently available data regarding this adverse event, to identify any clinical patterns in the cohort of reported patients, and to review the possible immunopathogenesis. Methods: A systematic literature review was performed utilizing PubMed and Medline databases (1996 to August 2009) searching the index terms "tumor necrosis factor alpha inhibitor," "TNF," "infliximab," "etanercept," "adalimumab," combined with the terms "psoriasis," "pustular," "skin," "rash," "palmoplantar," and "paradoxical." All relevant articles were reviewed. Patients who did not appear to meet accepted classification criteria for their treated disease, who had a more probable explanation or other likely diagnosis for their skin findings or known possible triggering factor for the skin eruption, including infection, were excluded from this analysis. Results: Two hundred seven cases met inclusion criteria for review. Of these, 43% were diagnosed with rheumatoid arthritis, 26% with seronegative spondyloarthropathy, and 20% with inflammatory bowel disease. Mean patient age was 45 years and 65% were female. Fifty-nine percent were being treated with infliximab, 22% with adalimumab, and 19% with etanercept. Lesion morphology included pustular psoriasis in 56%, plaque psoriasis in 50%, and guttate lesions in 12%; 15% experienced lesions of more than 1 type. No statistically significant predisposing factors for the development of new-onset psoriasis were found. Sixty-six percent of patients were able to continue TNF antagonist therapy with psoriasis treatments. The pathogenesis appears to involve disruption of the cytokine milieu with production of unopposed interferon-alpha production by plasmacytoid dendritic cells in genetically predisposed individuals. Genetic polymorphisms may play a role in this paradoxical reaction to TNF blockade. Conclusions: TNF antagonist induced psoriasis is a well-described adverse event without any known predisposing risk factors. Most patients can be managed conservatively without drug withdrawal. Registry data reporting is necessary to define the true incidence and prevalence of this condition. Genomic studies of affected patients may assist with identification of predisposed patients and elucidation of the molecular trigger of this perplexing response. Published by Elsevier Inc. Semin Arthritis Rheum 40:233-240 C1 [Collamer, Angelique N.; Battafarano, Daniel F.] Brooke Army Med Ctr, Rheumatol Serv, Ft Sam Houston, TX 78234 USA. RP Collamer, AN (reprint author), Brooke Army Med Ctr, Rheumatol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM angelique.collamer@us.af.mil NR 109 TC 90 Z9 95 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0049-0172 EI 1532-866X J9 SEMIN ARTHRITIS RHEU JI Semin. Arthritis Rheum. PD DEC PY 2010 VL 40 IS 3 BP 233 EP 240 DI 10.1016/j.semarthrit.2010.04.003 PG 8 WC Rheumatology SC Rheumatology GA 694GL UT WOS:000285282900007 PM 20580412 ER PT J AU Toren, KL Parlette, EC AF Toren, Kristen L. Parlette, Eric C. TI Managing Melanoma In Situ SO SEMINARS IN CUTANEOUS MEDICINE AND SURGERY LA English DT Article ID LENTIGO MALIGNA MELANOMA; MOHS MICROGRAPHIC SURGERY; 5-PERCENT IMIQUIMOD CREAM; PRIMARY CUTANEOUS MELANOMA; SUN-DAMAGED SKIN; TERM-FOLLOW-UP; TOPICAL IMIQUIMOD; STAGED EXCISION; SURGICAL MARGINS; FROZEN-SECTIONS AB Melanoma is a highly aggressive skin cancer with an increasing incidence. Melanoma in situ is an early, non-invasive form in which the tumor is confined to the epidermis. Treatment of melanoma in situ is challenging due to the frequent subclinical microscopic spread and to the presentation on the head and neck in cosmetically sensitive areas with chronic sun damage. Optimizing tumor eradication is imperative to reduce the potential progression into invasive disease and metastasis, all while maintaining cosmesis. Multiple treatment regimens have been implemented for managing difficult melanoma in situ tumors. We provide a thorough review of surgical, and non-surgical, management of melanoma in situ which can pose therapeutic dilemmas due to size, anatomic location, and subclinical spread. Semin Cutan Med Surg 29:258-263 (C) 2010 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. [Parlette, Eric C.] Dermatol Associates, Winchester, MA USA. RP Parlette, EC (reprint author), Dermatol Associate, Winchester, MA USA. EM ecparlette@hounail.com NR 80 TC 4 Z9 4 U1 0 U2 2 PU FRONTLINE MEDICAL COMMUNICATIONS PI THE WOODLANDS PA WRIGHTS MEDIA, 2407 TIMBERLOCH PLACE, SUITE B, THE WOODLANDS, TX 77386 USA SN 1085-5629 EI 1558-0768 J9 SEMIN CUTAN MED SURG JI Semin. Cutan. Med. Surg. PD DEC PY 2010 VL 29 IS 4 BP 258 EP 263 DI 10.1016/j.sder.2010.10.002 PG 6 WC Dermatology; Surgery SC Dermatology; Surgery GA 721UB UT WOS:000287382200008 PM 21277539 ER PT J AU Guerrero, ML Kim, D Rupp, TL Balkin, TJ AF Guerrero, Melanie L. Kim, Daniel Rupp, Tracy L. Balkin, Thomas J. TI Oral appliance titration in patients with obstructive sleep apnea induces the appearance of periodic limb movements SO SLEEP AND BREATHING LA English DT Article DE Obstructive sleep apnea; Oral appliance; Periodic limb movement; Excessive daytime sleepiness; Continuous positive airway pressure ID POSITIVE AIRWAY PRESSURE; RESISTANCE SYNDROME; LEG MOVEMENTS; PREVALENCE; POPULATION; DISORDER AB Study objectives Oral appliance (OA) therapy is considered a first line choice of therapy for some patients with mild or moderate obstructive sleep apnea (OSA) and an alternative form of treatment in those intolerant of continuous positive airway pressure (CPAP) use. According to several studies, periodic limb movements (PLM) appear during effective treatment of OSA with CPAP, but a similar phenomenon has not been described with the use of oral appliance. Herein, we describe the incidence of PLM in patients with OSA who underwent oral appliance therapy titration. Design This is a prospective, observational study set in a six-bed sleep center in an academic, military referral hospital. Patients and methods Patients with OSA (n=21; 15 men and six women; mean age, 43 years; and age range, 25 to 53 years) treated with OA during a 1-year period were enrolled. Patients were categorized according to the severity of sleep apnea and incidence of PLIvl on diagnostic polysomnography. Effective treatment of OSA and appearance or disappearance of PLM with arousal on subsequent oral appliance titration polysomnography were recorded and compared. Results Twenty-one patients were enrolled. During baseline polysomnography, three of 21(14%) patients had five or more PLM with arousal per hour while 11 of 21 (52%) patients had PLM with arousal during the oral appliance titration trial. Conclusion Oral appliance therapy for obstructive sleep apnea is an effective treatment and ideal for use in military recruits. The appearance of periodic limb movements with arousal during oral appliance use should be considered as a cause of persistent daytime sleepiness despite effective treatment of obstructive sleep apnea in this subset of patients. C1 [Guerrero, Melanie L.; Rupp, Tracy L.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. [Guerrero, Melanie L.; Kim, Daniel] Walter Reed Army Med Ctr, Dept Med Pulm Crit Care & Sleep Serv, Washington, DC 20307 USA. RP Guerrero, ML (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Melanie.guerrero@us.army.mil NR 20 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD DEC PY 2010 VL 14 IS 4 BP 359 EP 363 DI 10.1007/s11325-009-0321-z PG 5 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 717AO UT WOS:000287014800010 PM 20099083 ER PT J AU Kusiak, P AF Kusiak, Pauline TI Instrumentalized rationality, cross-cultural mediators, and civil epistemologies of late colonialism SO SOCIAL STUDIES OF SCIENCE LA English DT Article DE Africa; colonialism; postcolonialism; techno-politics; visual culture ID AFRICA AB This paper builds upon studies of the constitutive role of technology in the establishment of colonial order by demonstrating some of the ways in which a relationship between spiritual authority and technologies of the secular state came to be articulated together in the late colonial period, and hence embedded within contemporary postcolonial techno-politics. Focusing on adult public health campaigns in French West Africa, I suggest that that the end of colonialism sparked a host of debates about what counted as knowledge of political reality, the means to obtain that knowledge and the persons in which such knowledge was vested. Within this turbulent context, ideas about the 'magico-spiritual' were woven together with 'secular' instruments of the state, in the process forging new conceptions of political reality. By describing the dynamics of this process, my analysis of African socio-technical systems modulates some key science studies frameworks to make them more applicable to contemporary non-Western settings. While science studies can more than adequately account for how technology may be used to build 'the nation', to be applicable to postcolonial contexts such studies should also be able to address the role of socio-technical contestation for producing techno-political states of enduring instability and disequilibrium. C1 [Kusiak, Pauline] Northwestern Univ, African Studies Program, Evanston, IL 60208 USA. [Kusiak, Pauline] USA, Special Operat Command, Ft Bragg, NC USA. RP Kusiak, P (reprint author), 7445 Digby Green, Alexandria, VA 22315 USA. EM pauline.kusiak@gmail.com FU National Science Foundation [0135537] FX The author wishes to thank the anonymous reviewers and journal editors for their helpful comments. This work was supported by the National Science Foundation (grant number 0135537). The views expressed in this paper are those of the author alone and do not represent the views of the Office of the Secretary of Defense or the Department of Defense. NR 110 TC 4 Z9 4 U1 0 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0306-3127 EI 1460-3659 J9 SOC STUD SCI JI Soc. Stud. Sci. PD DEC PY 2010 VL 40 IS 6 BP 871 EP 902 DI 10.1177/0306312710372436 PG 32 WC History & Philosophy Of Science SC History & Philosophy of Science GA 690ZJ UT WOS:000285049100003 ER PT J AU Sailliol, A Clavier, B Cap, A Ausset, S AF Sailliol, A. Clavier, B. Cap, A. Ausset, S. TI French European military haemovigilance guidelines SO TRANSFUSION CLINIQUE ET BIOLOGIQUE LA French DT Article DE Haemovigilance; Traceability; Army; Blood; NATO; Stanag ID FRESH WHOLE-BLOOD; MASSIVE TRANSFUSION AB European military transfusion services follow operational guidelines established by their respective national health systems and conform with European Union directives and NATO standards as applicable to member countries. Certain features are common to all of these standards, especially the pre-selection of volunteer, almost exclusively unpaid donors. NATO requirements are very close to European guidelines, with the exception that NATO permits the use of blood products collected in emergency conditions in theater when circumstances allow no better option. Blood product traceability exists for every country but is not always centralized or computerized. Serious adverse event reporting relies on national haemovigilance networks. Military considerations become important mainly in overseas operations, where the overall policy is to implement the relevant national, European or NATO guidelines with adjustments made for unique wartime circumstances and the risk/benefit ratio for the individual patient needing a transfusion. (C) 2010 Elsevier Masson SAS. All rights reserved. C1 [Sailliol, A.; Clavier, B.] Ctr Transfus Sanguine Armees, F-92140 Clamart, France. [Cap, A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ausset, S.] Hop Instruct Armees Percy, Serv Anesthesie Reanimat, F-92140 Clamart, France. RP Sailliol, A (reprint author), Ctr Transfus Sanguine Armees, 1 Rue Raoul Batany, F-92140 Clamart, France. EM anne.sailliol@wanadoo.fr NR 8 TC 5 Z9 6 U1 0 U2 1 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 1246-7820 J9 TRANSFUS CLIN BIOL JI Transfu. Clin. Biol. PD DEC PY 2010 VL 17 IS 5-6 BP 315 EP 317 DI 10.1016/j.tracli.2010.09.001 PG 3 WC Hematology; Immunology SC Hematology; Immunology GA 697FO UT WOS:000285498200010 PM 21051263 ER PT J AU Rhee, IS AF Rhee, In-Sik TI Assessing the Biodegradability of Hydraulic Fluids Using a Bio-Kinetic Model SO TRIBOLOGY & LUBRICATION TECHNOLOGY LA English DT Article DE Biodegradability; Hydraulic Fluids AB Throughout the industrial age, natural resources have been turned into products no longer recognizable by microorganisms and enzymes converting natural substances into their basic building bocks. To make more environmentally friendly products, significant efforts are being made to develop biodegradable materials and technologies fully compatible with the environment. One of the concerns in these efforts is the evaluation of their biodegradability in laboratory environments within a short period. Currently, several ASTM and OECD biodegradation test methods are available for determining this environmental property, but they take a long time (28 days) and special biological knowledge is required. To resolve this problem, a bio-kinetic model was developed to predict the biodegradability of hydraulic fluids. This report presents how to develop a bio-kinetic model and its results are discussed in a comparison with the modified Sturm test (ASTM D 5864) and the Aerobic Closed Respirometer test (ASTM D 6731). C1 US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI USA. RP Rhee, IS (reprint author), US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 840 BUSSE HIGHWAY, PARK RIDGE, IL 60068 USA SN 1545-858X J9 TRIBOL LUBR TECHNOL JI Tribol. Lubr. Technol. PD DEC PY 2010 VL 66 IS 12 BP 60 EP 65 PG 6 WC Engineering, Mechanical SC Engineering GA 692TZ UT WOS:000285179300015 ER PT J AU Peachman, KK Wieczorek, L Matyas, GR Polonis, VR Alving, CR Rao, M AF Peachman, Kristina K. Wieczorek, Lindsay Matyas, Gary R. Polonis, Victoria R. Alving, Carl R. Rao, Mangala TI The Importance of Antibody Isotype in HIV-1 Virus Capture Assay and in TZM-bl Neutralization SO VIRAL IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; LIPID EPITOPES; MONOCLONAL-ANTIBODIES; SIMULTANEOUSLY BIND; TYPE-1; LIPOSOMES; PROTEIN; INTACT; 2F5; PHOSPHOINOSITIDES AB The binding of murine IgM mAbs to five different clades of HIV-1 was examined using a modified ELISA-based virus capture assay. Two murine multispecific IgM mAbs that exhibit both lipid and gp41 epitope specificities, and one murine IgM mAb that exhibits lipid-binding specificity, were utilized. The binding of the IgG and the IgM isotypes of human mAb 2F5 to clades A through AE were also evaluated. The binding of 2F5 to HIV-1 was dependent upon the antibody isotype. Monoclonal IgM antibodies bound significantly lower amounts of HIV-1 than the corresponding IgG isotype. Although murine IgM mAbs bound HIV-1 to varying degrees in the virus capture assay, they failed to neutralize HIV-1 in a TZM-bl pseudovirus assay. In contrast, 2F5-IgM mAb bound certain HIV-1 isolates, and also neutralized them, although not as efficiently as the 2F5-IgG isotype. Studies on the relationship between virus binding and neutralization in a TZM-bl pseudovirus assay indicated that in most cases, mAbs that exhibited neutralization also bound the virus. C1 [Rao, Mangala] Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. [Peachman, Kristina K.; Wieczorek, Lindsay] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mrao@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 23 TC 2 Z9 2 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 J9 VIRAL IMMUNOL JI Viral Immunol. PD DEC PY 2010 VL 23 IS 6 BP 627 EP 632 DI 10.1089/vim.2010.0061 PG 6 WC Immunology; Virology SC Immunology; Virology GA 691PM UT WOS:000285093300010 PM 21142448 ER PT J AU Nyein, MK Jason, AM Yu, L Pita, CM Joannopoulos, JD Moore, DF Radovitzky, RA AF Nyein, Michelle K. Jason, Amanda M. Yu, Li Pita, Claudio M. Joannopoulos, John D. Moore, David F. Radovitzky, Raul A. TI In silico investigation of intracranial blast mitigation with relevance to military traumatic brain injury SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE computational models; personal protection equipment ID VIRTUAL TEST FACILITY; IRAQ; AFGHANISTAN; MECHANISMS; SIMULATION; CARE; TBI; WAR AB Blast-induced traumatic brain injury is the most prevalent military injury in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head, and still less is known about how personal protective equipment affects the brain's response to blasts. In this study we investigated the effect of the Advanced Combat Helmet (ACH) and a conceptual face shield on the propagation of stress waves within the brain tissue following blast events. We used a sophisticated computational framework for simulating coupled fluid-solid dynamic interactions and a three-dimensional biofidelic finite element model of the human head and intracranial contents combined with a detailed model of the ACH and a conceptual face shield. Simulations were conducted in which the unhelmeted head, head with helmet, and head with helmet and face shield were exposed to a frontal blast wave with incident overpressure of 10 atm. Direct transmission of stress waves into the intracranial cavity was observed in the unprotected head and head with helmet simulations. Compared to the unhelmeted head, the head with helmet experienced slight mitigation of intracranial stresses. This suggests that the existing ACH does not significantly contribute to mitigating blast effects, but does not worsen them either. By contrast, the helmet and face shield combination impeded direct transmission of stress waves to the face, resulting in a delay in the transmission of stresses to the intracranial cavity and lower intracranial stresses. This suggests a possible strategy for mitigating blast waves often associated with military concussion. C1 [Joannopoulos, John D.] MIT, Dept Phys, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. [Nyein, Michelle K.; Jason, Amanda M.; Yu, Li; Pita, Claudio M.; Radovitzky, Raul A.] MIT, Dept Aeronaut & Astronaut, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. [Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Joannopoulos, JD (reprint author), MIT, Dept Phys, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. EM joannop@mit.edu; rapa@mit.edu RI Radovitzky, Raul/A-5353-2009 OI Radovitzky, Raul/0000-0001-6339-2708 FU Joint Improvised Explosive Device Defeat Organization through the Army Research Office; MIT Institute for Soldier Nanotechnologies FX This work was supported by financial aid from the Joint Improvised Explosive Device Defeat Organization through the Army Research Office. Partial support from the MIT Institute for Soldier Nanotechnologies is also gratefully acknowledged. NR 33 TC 59 Z9 59 U1 2 U2 18 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 30 PY 2010 VL 107 IS 48 BP 20703 EP 20708 DI 10.1073/pnas.1014786107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 687ET UT WOS:000284762400025 PM 21098257 ER PT J AU Crum-Cianflone, NF Hullsiek, KH Ganesan, A Weintrob, A Okulicz, JF Agan, BK AF Crum-Cianflone, Nancy F. Hullsiek, Katherine Huppler Ganesan, Anuradha Weintrob, Amy Okulicz, Jason F. Agan, Brian K. CA Infectious Dis Clinical Res TI Is Kaposi's sarcoma occurring at higher CD4 cell counts over the course of the HIV epidemic? SO AIDS LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; UNITED-STATES; INFECTED PERSONS; IMPACT; AIDS; SEROCONVERSION; INDIVIDUALS; FEATURES; CANCERS; TRENDS C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Weintrob, Amy; Okulicz, Jason F.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Department of Defense (DoD) [IDCRP-000-04] FX Support for this work (IDCRP-000-04) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD, the Departments of the Army, Navy or Air Force, nor the US Government. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. The authors acknowledge that the research protocol ('Incidence and Risk Factors for AIDS-Defining and Non-AIDS-Defining Cancers in an HIV-Infected Cohort') received applicable Institutional Board review and approval. NR 19 TC 7 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD NOV 27 PY 2010 VL 24 IS 18 BP 2881 EP 2883 DI 10.1097/QAD.0b013e32833f9fb8 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 678EU UT WOS:000284057300017 PM 20827160 ER PT J AU Matyas, GR Wieczorek, L Bansal, D Chenine, AL Sanders-Buell, E Tovanabutra, S Kim, JH Polonis, V Alving, CR AF Matyas, Gary R. Wieczorek, Lindsay Bansal, Divya Chenine, Agnes-Laurence Sanders-Buell, Eric Tovanabutra, Sodsai Kim, Jerome H. Polonis, Victoria Alving, Carl R. TI Inhibition of HIV-1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of beta-chemokines SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Liposomes; Antibodies to phospholipids; Phosphoinositides; Chemokines; HIV 1 neutralizing antibodies; Peripheral blood mononuclear cells ID HUMAN-IMMUNODEFICIENCY-VIRUS; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PLASMA-MEMBRANE; LIPID EPITOPES; PHOSPHATE; MITOGENESIS; LIPOSOMES; TYPE-1 AB A murine IgG mAb WR321 selected for the ability to bind to phosphatidylinositol-4-phosphate and phosphatidylinositol-4 5-bisphosphate but an inability to bind to any of 17 other lipids including phosphatidylinositol was examined as a probe for studying interactions of HIV-1 with primary human peripheral blood mononuclear cells The WR321 mAb broadly neutralized CCR5 tropic strains of HIV-1 to prevent infection of the cells The mAb also exhibited direct interaction with cells in the culture resulting in secretion of chemokines that interfered with the interaction of HIV-1 virions with CCR5 the coreceptor for HIV-1 on the susceptible cells leading to inhibition of infection by HIV-1 Phosphoinositides that are recognized by WR321 do not exist on the external surface of cells but are concentrated on the inner surface (cytoplasmic leaflet) of the plasma membrane Murine anti-phosphoinositide mAbs similar to WR321 have previously been directly microinjected Into a variety of cultured cells resulting in important changes in the functions of the cells The present results suggest that binding of a mAb to phosphoinositides resulting in secretion of beta-chemokines into the culture medium and neutralization of infection by CCR5-tropic HIV-1 of nearby susceptible cells occurred by uptake and binding of the mAb at an intracellular location in the cultured cells that then led to secretion of HIV-1-inhibitory beta-chemokines Published by Elsevier Inc C1 [Alving, Carl R.] Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. [Wieczorek, Lindsay; Bansal, Divya; Chenine, Agnes-Laurence; Sanders-Buell, Eric; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD 20850 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. FU Henry M Jackson Foundation for the Advancement of Military Medicine [DAMD17-93-V-3004]; US Army Medical Research and Material Command [93-V-3004]; Division of AIDS National Institute for Allergy and Infectious Diseases NIH Bethesda MD Research FX This work was supported through Cooperative Agreement No DAMD17-93-V-3004 between the Henry M Jackson Foundation for the Advancement of Military Medicine and the US Army Medical Research and Material Command working together with the Division of AIDS National Institute for Allergy and Infectious Diseases NIH Bethesda MD Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals NRC Publication 1996 edition The views and opinions expressed herein are the private opinions of the authors and do not necessarily reflect the views of the US Army or the US Department of Defense NR 28 TC 8 Z9 8 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 26 PY 2010 VL 402 IS 4 BP 808 EP 812 DI 10.1016/j.bbrc.2010.10.124 PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 692QW UT WOS:000285171200040 PM 21040700 ER PT J AU Mulligan, CP Blanchet, TA Gall, D AF Mulligan, C. P. Blanchet, T. A. Gall, D. TI Control of lubricant transport by a CrN diffusion barrier layer during high-temperature sliding of a CrN-Ag composite coating SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 37th International Conference on Metallurgical Coatings and Thin Films CY APR 26-30, 2010 CL San Diego, CA SP Amer Vacuum Soc, Adv Surface Engn Div DE CrN-Ag; Nanocomposite coating; Solid lubrication; High-temperature materials; Sliding wear; Diffusion barrier ID ENERGY ION-IRRADIATION; NANOCOMPOSITE COATINGS; TRIBOLOGICAL APPLICATIONS; HARD COATINGS; GROWTH; FILMS; MICROSTRUCTURE; COMPONENTS; EVOLUTION; SILVER AB CrN-Ag composite coatings, 2 and 5 pm thick and containing 22 at.% Ag solid lubricant, were grown on Si(001) and 440C stainless steel substrates by reactive co-sputtering at T-s = 500 degrees C, and were covered with 200 nm thick pure CrN diffusion barrier cap layers. Annealing experiments at T-a = 625 degrees C, followed by quantitative scanning electron microscopy, energy dispersive x-ray spectroscopy, and Auger depth profile analyses indicate considerable Ag transport to the top surface for a barrier layer deposited at a substrate floating potential of -30 V, but negligible Ag diffusion when deposited with a substrate bias potential of -150 V. This is attributed to ion-irradiation induced densification which makes the cap layer an effective diffusion barrier. High temperature tribological sliding tests of this coating system against alumina balls at T-t = 550 degrees C indicate an initial friction coefficient mu = 0.43 +/- 0.04 which decreases monotonically to 0.23 +/- 0.03. This is attributed to the development of wear mediated openings in the barrier layer which allow Ag lubricant to diffuse to the sliding top surface. In contrast, pure CrN exhibits a constant mu = 0.41 +/- 0.02 while CrN-Ag composite coatings without cap layer show a low transient mu = 0.16 +/- 0.03, attributed to Ag transport to the surface, that however increases to mu = 0.39 +/- 0.04 after -6000 cycles as the Ag reservoir in the coating is depleted. That is, the dense CrN cap layer reduces the Ag lubricant flow rate and therefore prolongs the time when the coating provides effective lubrication. This results in a cumulative wear rate over 10,000 cycles of 3.1 x 10(-6) mm(3)/Nm, which is 3.3 x lower than without diffusion barrier layer. Published by Elsevier B.V. C1 [Mulligan, C. P.] USA, Benet Labs, RDAR WSB LB, Armament Res Dev & Engn Ctr, Watervliet, NY 12189 USA. [Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Blanchet, T. A.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. RP Mulligan, CP (reprint author), USA, Benet Labs, RDAR WSB LB, Armament Res Dev & Engn Ctr, 1 Buffington St,Bldg 115, Watervliet, NY 12189 USA. EM c.mulligan@us.army.mil RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 NR 33 TC 22 Z9 22 U1 1 U2 13 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD NOV 25 PY 2010 VL 205 IS 5 BP 1350 EP 1355 DI 10.1016/j.surfcoat.2010.07.071 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 697BN UT WOS:000285487700031 ER PT J AU Spalding, MD Eyase, FL Akala, HM Bedno, SA Prigge, ST Coldren, RL Moss, WJ Waters, NC AF Spalding, Maroya D. Eyase, Fredrick L. Akala, Hoseah M. Bedno, Sheryl A. Prigge, Sean T. Coldren, Rodney L. Moss, William J. Waters, Norman C. TI Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya SO MALARIA JOURNAL LA English DT Article ID INTERMITTENT PREVENTIVE TREATMENT; PLASMODIUM-FALCIPARUM MALARIA; PLACEBO-CONTROLLED TRIAL; DIHYDROPTEROATE-SYNTHETASE GENES; STANDARD ANTIMALARIAL-DRUGS; IN-VITRO ACTIVITY; DIHYDROFOLATE-REDUCTASE; SULFADOXINE-PYRIMETHAMINE; POINT MUTATIONS; ARTEMETHER-LUMEFANTRINE AB Background: Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ) as the first-line anti-malarial in 1998 and artemether-lumefantrine (AL) replaced SP in 2004. Two cross-sectional studies were conducted to monitor changes in the prevalence of molecular markers of drug resistance over the period in which SP was used as the first-line antimalarial. The baseline study was carried out from 1999-2000, shortly after implementation of SP, and the follow-up study occurred from 2003-2005, during the transition to AL. Materials and methods: Blood was collected from malaria smear-positive, symptomatic patients presenting to outpatient centers in Kisumu, Kenya, during the baseline and follow-up studies. Isolates were genotyped at codons associated with SP and CQ resistance. In vitro IC(50) values for antifolates and quinolones were determined for isolates from the follow-up study. Results: The prevalence of isolates containing the pfdhfr N51I/C59R/S108N/pfdhps A437G/K540E quintuple mutant associated with SP-resistance rose from 21% in the baseline study to 53% in the follow-up study (p < 0.001). Isolates containing the pfdhfr I164L mutation were absent from both studies. The pfdhps mutations A581G and A613S/T were absent from the baseline study but were present in 85% and 61%, respectively, of isolates from the follow-up study. At follow-up, parasites with mutations at five pfdhps codons, 436, 437, 540, 581, and 613, accounted for 39% of isolates. The CQ resistance-associated mutations pfcrt K76T and pfmdr1 N86Y rose from 82% to 97% (p = 0.001) and 44% to 76% (p < 0.001), respectively, from baseline to follow-up. Conclusions: During the period in which SP was the first-line anti-malarial in Kenya, highly SP-resistant parasites emerged, including isolates harboring pfdhps mutations not previously observed there. SP continues to be widely used in Kenya; however, given the highly resistant genotypes observed in this study, its use as a first-line antimalarial should be discouraged, particularly for populations without acquired immunity to malaria. The increase in the pfcrt K76T prevalence, despite efforts to reduce CQ use, suggests that either these efforts are not adequate to alleviate CQ pressure in Kisumu, or that drug pressure is derived from another source, such as the second-line antimalarial amodiaquine. C1 [Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Spalding, Maroya D.; Moss, William J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Eyase, Fredrick L.; Akala, Hoseah M.] United States Army Res Unit, Kenya Walter Reed KEMRI Project, Kisumu, Kenya. [Bedno, Sheryl A.; Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Spalding, Maroya D.; Prigge, Sean T.; Moss, William J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM norman.waters@us.army.mil RI Valle, Ruben/A-7512-2013 FU U.S. Army; Department of Defense-Global Emerging Infections System; Johns Hopkins Malaria Research Institute FX This work was funded by the U.S. Army, Military Infectious Disease Research Program, and the Department of Defense-Global Emerging Infections System. MDS was supported by a Johns Hopkins Malaria Research Institute Pre-doctoral Fellowship. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 56 TC 24 Z9 24 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 24 PY 2010 VL 9 AR 338 DI 10.1186/1475-2875-9-338 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 724UR UT WOS:000287602200002 PM 21106088 ER PT J AU Filone, CM Hanna, SL Caino, MC Bambina, S Doms, RW Cherry, S AF Filone, Claire Marie Hanna, Sheri L. Caino, M. Cecilia Bambina, Shelly Doms, Robert W. Cherry, Sara TI Rift Valley Fever Virus Infection of Human Cells and Insect Hosts Is Promoted by Protein Kinase C Epsilon SO PLOS ONE LA English DT Article ID DROSOPHILA-MELANOGASTER; GENE-EXPRESSION; GENOME; ENTRY; INHIBITION; MACROPINOCYTOSIS; MOSQUITO; REVEALS; PKC; PHOSPHORYLATION AB As an arthropod-borne human pathogen, Rift Valley fever virus (RVFV) cycles between an insect vector and mammalian hosts. Little is known about the cellular requirements for infection in either host. Here we developed a tissue culture model for RVFV infection of human and insect cells that is amenable to high-throughput screening. Using this approach we screened a library of 1280 small molecules with pharmacologically defined activities and identified 59 drugs that inhibited RVFV infection with 15 inhibiting RVFV replication in both human and insect cells. Amongst the 15 inhibitors that blocked infection in both hosts was a subset that inhibits protein kinase C. Further studies found that infection is dependent upon the novel protein kinase C isozyme epsilon (PKC epsilon) in both human and insect cells as well as in adult flies. Altogether, these data show that inhibition of cellular factors required for early steps in the infection cycle including PKC epsilon can block RVFV infection, and may represent a starting point for the development of anti-RVFV therapeutics. C1 [Filone, Claire Marie; Hanna, Sheri L.; Bambina, Shelly; Doms, Robert W.; Cherry, Sara] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA. [Cherry, Sara] Univ Penn, Sch Med, Penn Genome Frontiers Inst, Philadelphia, PA 19104 USA. [Caino, M. Cecilia] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA. RP Filone, CM (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM cherrys@mail.med.upenn.edu FU MARCE [U54 AI 057168] FX This work was supported by the MARCE U54 AI 057168 to RD and SC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 23 Z9 23 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 24 PY 2010 VL 5 IS 11 AR e15483 DI 10.1371/journal.pone.0015483 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 684TK UT WOS:000284572000028 PM 21124804 ER PT J AU Fang, X Wallqvist, A Reifman, J AF Fang, Xin Wallqvist, Anders Reifman, Jaques TI Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis SO BMC SYSTEMS BIOLOGY LA English DT Article ID IN-SILICO MODELS; INFECTED MICE; NITRIC-OXIDE; MOUSE LUNG; RECONSTRUCTION; MACROPHAGES; GROWTH; GENE; RESPIRATION; EXPRESSION AB Background: During infection, Mycobacterium tuberculosis confronts a generally hostile and nutrient-poor in vivo host environment. Existing models and analyses of M. tuberculosis metabolic networks are able to reproduce experimentally measured cellular growth rates and identify genes required for growth in a range of different in vitro media. However, these models, under in vitro conditions, do not provide an adequate description of the metabolic processes required by the pathogen to infect and persist in a host. Results: To better account for the metabolic activity of M. tuberculosis in the host environment, we developed a set of procedures to systematically modify an existing in vitro metabolic network by enhancing the agreement between calculated and in vivo-measured gene essentiality data. After our modifications, the new in vivo network contained 663 genes, 838 metabolites, and 1,049 reactions and had a significantly increased sensitivity (0.81) in predicted gene essentiality than the in vitro network (0.31). We verified the modifications generated from the purely computational analysis through a review of the literature and found, for example, that, as the analysis suggested, lipids are used as the main source for carbon metabolism and oxygen must be available for the pathogen under in vivo conditions. Moreover, we used the developed in vivo network to predict the effects of double-gene deletions on M. tuberculosis growth in the host environment, explore metabolic adaptations to life in an acidic environment, highlight the importance of different enzymes in the tricarboxylic acid-cycle under different limiting nutrient conditions, investigate the effects of inhibiting multiple reactions, and look at the importance of both aerobic and anaerobic cellular respiration during infection. Conclusions: The network modifications we implemented suggest a distinctive set of metabolic conditions and requirements faced by M. tuberculosis during host infection compared with in vitro growth. Likewise, the doublegene deletion calculations highlight the importance of specific metabolic pathways used by the pathogen in the host environment. The newly constructed network provides a quantitative model to study the metabolism and associated drug targets of M. tuberculosis under in vivo conditions. C1 [Fang, Xin; Wallqvist, Anders; Reifman, Jaques] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT) FX We thank Dr. Chenggang Yu for his providing comprehensive analysis on gene annotation of M. tuberculosis to obtain genes directly associated with metabolic processes. This project was funded in part by a competitive In-house Laboratory Independent Research (ILIR) grant by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 81 TC 25 Z9 26 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD NOV 23 PY 2010 VL 4 AR 160 DI 10.1186/1752-0509-4-160 PG 24 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 696ZK UT WOS:000285479700001 PM 21092312 ER PT J AU Ji, SY Ward, K Bsoul, AAR Luo, YR Ryan, K Rickards, C Convertino, V Najarian, K AF Ji, Soo-Yeon Ward, Kevin Bsoul, Abed Al Raoof Luo, Yurong Ryan, Kathy Rickards, Caroline Convertino, Victor Najarian, Kayvan TI Developing a Hypovolemia Monitoring System by Integrating Physiological Measures and P-QRS-T Waves SO CIRCULATION LA English DT Meeting Abstract DE Electrocardiography; Cardiovascular disease; Heart rate/Heart rate variability C1 Virginia Commonwealth Univ, Reanimat Engn Sci Cntr, Richmond, VA USA. USA, Inst Surg Rsch, San Antonio, TX USA. Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 23 PY 2010 VL 122 IS 21 SU S MA A272 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA V21UD UT WOS:000208231600257 ER PT J AU Liu, NT Baker, WL Batchinsky, AI Salinas, J Cancio, LC AF Liu, Nehemiah T. Baker, William L. Batchinsky, Andriy I. Salinas, Jose Cancio, Leopoldo C. TI Enhancing QRS Detection Using the Automated Electrocardiogram Selection of Peaks (AESOP) Algorithm SO CIRCULATION LA English DT Meeting Abstract DE Electrocardiography; Heart rate/Heart rate variability; Research C1 [Liu, Nehemiah T.; Baker, William L.; Batchinsky, Andriy I.; Salinas, Jose; Cancio, Leopoldo C.] USA, Inst Surg Rsch, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 23 PY 2010 VL 122 IS 21 SU S MA A156 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA V21UD UT WOS:000208231600145 ER PT J AU Geyer, BC Kannan, L Garnaud, PE Broomfield, CA Cadieux, CL Cherni, I Hodgins, SM Kasten, SA Kelley, K Kilbourne, J Oliver, ZP Otto, TC Puffenberger, I Reeves, TE Robbins, N Woods, RR Soreq, H Lenz, DE Cerasoli, DM Mor, TS AF Geyer, Brian C. Kannan, Latha Garnaud, Pierre-Emmanuel Broomfield, Clarence A. Cadieux, C. Linn Cherni, Irene Hodgins, Sean M. Kasten, Shane A. Kelley, Karli Kilbourne, Jacquelyn Oliver, Zeke P. Otto, Tamara C. Puffenberger, Ian Reeves, Tony E. Robbins, Neil, II Woods, Ryan R. Soreq, Hermona Lenz, David E. Cerasoli, Douglas M. Mor, Tsafrir S. TI Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE countermeasures; nonconventional warfare agents; organophosphorous pesticides; protein engineering; transgenic plants ID RECOMBINANT HUMAN ACETYLCHOLINESTERASE; ANHYDRIDE HYDROLASE ACTIVITY; POLYETHYLENE-GLYCOL; CIRCULATORY LONGEVITY; HUMAN PLASMA; EXPRESSION; TOXICITY; CHOLINESTERASE; MICE; BIOSCAVENGERS AB The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to clinical trial. However, the supply of the native human proteins is either limited (e. g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinesterase) or nonexisting (synaptic acetylcholinesterase). Here we identify a unique form of recombinant human butyrylcholinesterase that mimics the native enzyme assembly into tetramers; this form provides extended effective pharmacokinetics that is significantly enhanced by polyethylene glycol conjugation. We further demonstrate that this enzyme (but not a G117H/E197Q organophosphorus acid anhydride hydrolase catalytic variant) can prevent morbidity and mortality associated with organophosphorous nerve agent and pesticide exposure of animal subjects of two model species. C1 [Geyer, Brian C.; Kannan, Latha; Garnaud, Pierre-Emmanuel; Cherni, Irene; Kelley, Karli; Kilbourne, Jacquelyn; Puffenberger, Ian; Robbins, Neil, II; Woods, Ryan R.; Mor, Tsafrir S.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA. [Geyer, Brian C.; Kannan, Latha; Garnaud, Pierre-Emmanuel; Cherni, Irene; Kelley, Karli; Kilbourne, Jacquelyn; Puffenberger, Ian; Robbins, Neil, II; Woods, Ryan R.; Mor, Tsafrir S.] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA. [Broomfield, Clarence A.; Cadieux, C. Linn; Hodgins, Sean M.; Kasten, Shane A.; Oliver, Zeke P.; Otto, Tamara C.; Reeves, Tony E.; Lenz, David E.; Cerasoli, Douglas M.] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Soreq, Hermona] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel. RP Mor, TS (reprint author), Arizona State Univ, Sch Life Sci, POB 874501, Tempe, AZ 85287 USA. EM tsafrir.mor@asu.edu RI mor, tsafrir/E-9422-2013 FU National Institutes of Health through the National Institute of Neurological Disorders and Stroke [U-54-NSO58183-01, W81XWH-07-2-0023] FX This work was funded in part by the National Institutes of Health CounterACT Program through the National Institute of Neurological Disorders and Stroke under the U-54-NSO58183-01 award-a consortium grant awarded to US Army Medical Research Institute of Chemical Defense and contracted to T. S. M. under the research cooperative agreement W81XWH-07-2-0023. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 59 TC 34 Z9 35 U1 0 U2 12 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 23 PY 2010 VL 107 IS 47 BP 20251 EP 20256 DI 10.1073/pnas.1009021107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 684DT UT WOS:000284529000023 PM 21059932 ER PT J AU Roschewski, M Weniger, M Kurdziel, K Pittaluga, S Tian, X Tweito, M Dunleavy, K Wilson, WH Wiestner, A AF Roschewski, Mark Weniger, Marc Kurdziel, Karen Pittaluga, Stefania Tian, Xin Tweito, Megan Dunleavy, Kieron Wilson, Wyndham H. Wiestner, Adrian TI FDG-PET as a Marker of tumor proliferation Compared to Gene-Expression Proliferation Scores, MIB1%, and LDH In Untreated Mantle Cell Lymphoma (MCL) SO BLOOD LA English DT Meeting Abstract CT 52nd Annual Meeting of the American-Society-of-Hematology (ASH) CY DEC 04-07, 2010 CL Orlando, FL SP Amer Soc Hematol C1 [Roschewski, Mark] Walter Reed Army Med Ctr, Dept Hematol Oncol, Washington, DC 20307 USA. [Weniger, Marc; Wiestner, Adrian] NHLBI, Hematol Branch, Bethesda, MD 20892 USA. [Tweito, Megan; Dunleavy, Kieron; Wilson, Wyndham H.] NCI, CCR, NIH, Bethesda, MD 20892 USA. NR 0 TC 1 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 19 PY 2010 VL 116 IS 21 BP 1275 EP 1276 PG 2 WC Hematology SC Hematology GA 752BH UT WOS:000289662203425 ER PT J AU Strawn, AA Hwang, PF Davis, T Elster, E Tadaki, D Sheppard, F AF Strawn, Alan Anthony Hwang, Paul F. Davis, Thomas Elster, Eric Tadaki, Doug Sheppard, Forest TI Lyophilized Platelet Transfusion Does Not Constitute An Immunologic "Second Hit" In a Non-Human Primate Hemorrhagic Shock Model. SO BLOOD LA English DT Meeting Abstract CT 52nd Annual Meeting of the American-Society-of-Hematology (ASH) CY DEC 04-07, 2010 CL Orlando, FL SP Amer Soc Hematol C1 [Strawn, Alan Anthony; Elster, Eric; Sheppard, Forest] Natl Naval Med Ctr, Bethesda, MD USA. [Hwang, Paul F.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Davis, Thomas; Tadaki, Doug] USN, Med Res Ctr, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 19 PY 2010 VL 116 IS 21 BP 1376 EP 1376 PG 1 WC Hematology SC Hematology GA 752BH UT WOS:000289662203691 ER PT J AU Nakao, R Stromdahl, EY Magona, JW Faburay, B Namangala, B Malele, I Inoue, N Geysen, D Kajino, K Jongejan, F Sugimoto, C AF Nakao, Ryo Stromdahl, Ellen Y. Magona, Joseph W. Faburay, Bonto Namangala, Boniface Malele, Imna Inoue, Noboru Geysen, Dirk Kajino, Kiichi Jongejan, Frans Sugimoto, Chihiro TI Development of Loop-Mediated Isothermal Amplification (LAMP) Assays for Rapid Detection of Ehrlichia ruminantium SO BMC MICROBIOLOGY LA English DT Article ID AMBLYOMMA-VARIEGATUM TICKS; EMERGING HUMAN PATHOGEN; REAL-TIME PCR; COWDRIA-RUMINANTIUM; MOLECULAR-DETECTION; DNA AMPLIFICATION; AMERICAN MAINLAND; HEARTWATER; INFECTION; AGENT AB Background: The rickettsial bacterium Ehrlichia ruminantium is the causative agent of heartwater, a potential zoonotic disease of ruminants transmitted by ticks of the genus Amblyomma. The disease is distributed in nearly all of sub-Saharan Africa and some islands of the Caribbean, from where it threatens the American mainland. This report describes the development of two different loop-mediated isothermal amplification (LAMP) assays for sensitive and specific detection of E. ruminantium. Results: Two sets of LAMP primers were designed from the pCS20 and sodB genes. The detection limits for each assay were 10 copies for pCS20 and 5 copies for sodB, which is at least 10 times higher than that of the conventional pCS20 PCR assay. DNA amplification was completed within 60 min. The assays detected 16 different isolates of E. ruminantium from geographically distinct countries as well as two attenuated vaccine isolates. No cross-reaction was observed with genetically related Rickettsiales, including zoonotic Ehrlichia species from the USA. LAMP detected more positive samples than conventional PCR but less than real-time PCR, when tested with field samples collected in sub-Saharan countries. Conclusions: Due to its simplicity and specificity, LAMP has the potential for use in resource-poor settings and also for active screening of E. ruminantium in both heartwater-endemic areas and regions that are at risk of contracting the disease. C1 [Nakao, Ryo; Magona, Joseph W.; Kajino, Kiichi; Sugimoto, Chihiro] Hokkaido Univ, Res Ctr Zoonosis Control, Kita Ku, Sapporo, Hokkaido 0010020, Japan. [Stromdahl, Ellen Y.] USA, Publ Hlth Command Provis, Entomol Sci Program, Aberdeen Proving Ground, MD 21010 USA. [Magona, Joseph W.] Natl Livestock Resources Res Inst NaLIRRI, Tororo, Uganda. [Faburay, Bonto] Int Trypanotolerance Ctr, Banjul, Gambia. [Namangala, Boniface] Univ Zambia, Sch Vet Med, Dept Paraclin Studies, Lusaka, Zambia. [Malele, Imna] Tsetse & Trypanosomiasis Res Inst, Tanga, Tanzania. [Inoue, Noboru] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 08085555, Japan. [Geysen, Dirk] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium. [Jongejan, Frans] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, UCTD, NL-3584 CL Utrecht, Netherlands. [Jongejan, Frans] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa. [Faburay, Bonto] Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA. RP Sugimoto, C (reprint author), Hokkaido Univ, Res Ctr Zoonosis Control, Kita Ku, Kita 20,Nishi 10, Sapporo, Hokkaido 0010020, Japan. EM sugimoto@czc.hokudai.ac.jp RI Kajino, Kiichi/F-6873-2012; Nakao, Ryo/H-6889-2013 FU Japanese Society for the Promotion of Science (JSPS) for young scientists; Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT); Funding Research Center for Emerging and Re-emerging Infectious Disease, MEXT; MEXT FX The cattle and goat owners are greatly acknowledged for their cooperation. We are thankful to all personnel who assisted in collection of field samples in Uganda, Tanzania, and Zambia. We also thank Dr. Amanda Loftis for her facilitating work with the USA ehrlichiae and for her assistance editing this manuscript. The first author was supported by a research grant fellowship from the Japanese Society for the Promotion of Science (JSPS) for young scientists. This work was supported by Grant-in-Aid for JSPS fellows and for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), the program of Funding Research Center for Emerging and Re-emerging Infectious Disease, MEXT, and Asia-Africa S & T Strategic Cooperation Promotion Program by the Special Coordination Funds for Promoting Science & Technology, MEXT. NR 45 TC 32 Z9 33 U1 0 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD NOV 19 PY 2010 VL 10 AR 296 DI 10.1186/1471-2180-10-296 PG 11 WC Microbiology SC Microbiology GA 692YO UT WOS:000285192000001 PM 21087521 ER PT J AU Lee, WJ Kim, HH Choi, YK Choi, KM Kim, MA Kim, JY Sattabongkot, J Sohn, Y Kim, H Lee, JK Park, HS Lee, HW AF Lee, Won-Ja Kim, Hyung-Hwan Choi, Yien-Kyoung Choi, Kyung-Mi Kim, Mi-A Kim, Jung-Yeon Sattabongkot, Jetsumon Sohn, Youngjoo Kim, Hyuck Lee, Jong-Koo Park, Han-Sook Lee, Hyeong-Woo TI Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment SO MALARIA JOURNAL LA English DT Article ID SULFADOXINE-PYRIMETHAMINE; FALCIPARUM-MALARIA; ANTIMALARIAL-DRUGS; POINT MUTATION; IN-VITRO; RESISTANCE; INDONESIA; POLYMORPHISMS; ASSOCIATION; DHFR AB Background: To use pyrimethamine as an alternative anti-malarial drug for chloroquine-resistant malaria parasites, it was necessary to determine the enzyme's genetic variation in dihydrofolate reductase-thymidylate syntase (DHFR-TS) among Korean strains. Methods: Genetic variation of dhfr-ts genes of Plasmodium vivax clinical isolates from patients who did not respond to drug treatment (n = 11) in Korea were analysed. The genes were amplified using the polymerase chain reaction (PCR) with genomic DNA as a template. Results: Sequence analysis showed that the open reading frame (ORF) of 1,857 nucleotides encoded a deduced protein of 618 amino acids (aa). Alignment with the DHFR-TS genes of other malaria parasites showed that a 231 residue DHFR domain and a 286-residue TS domain were seperated by a 101-aa linker region. This ORF shows 98.7% homology with the P. vivax Sal I strain (XM001615032) in the DHFR domain, 100% in the linker region and 99% in the TS domain. Comparison of the DHFR sequences from pyrimethamine-sensitive and pyrimethamine-resistant P. vivax isolates revealed that nine isolates belonged to the sensitive strain, whereas two isolates met the criteria for resistance. In these two isolates, the amino acid at position 117 is changed from serine to asparagine (S117N). Additionally, all Korean isolates showed a deletion mutant of THGGDN in short tandem repetitive sequences between 88 and 106 amino acid. Conclusions: These results suggest that sequence variations in the DHFR-TS represent the prevalence of antifolate-resistant P. vivax in Korea. Two of 11 isolates have the Ser to Asn mutation in codon 117, which is the major determinant of pyrimethamine resistance in P. vivax. Therefore, the introduction of pyrimethamine for the treatment of chloroquine-resistant vivax malaria as alternative drug in Korea should be seriously considered. C1 [Lee, Hyeong-Woo] Univ Florida, Dept Pathol, Gainesville, FL 32610 USA. [Lee, Won-Ja; Choi, Yien-Kyoung; Choi, Kyung-Mi; Kim, Mi-A; Kim, Jung-Yeon; Park, Han-Sook] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, Natl Inst Hlth, Seoul 122701, South Korea. [Kim, Hyung-Hwan] Harvard Univ, Sch Med, Brigham & Womens Hosp, Vasc Med Res Unit, Cambridge, MA 02139 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Sohn, Youngjoo] Sangji Univ, Coll Oriental Med, Dept Gynecol, Wonju 220717, South Korea. [Kim, Hyung-Hwan; Kim, Hyuck] Int Res Ctr Biosci & Biotechnol, Goesan 367805, South Korea. [Lee, Jong-Koo] Korea Ctr Dis Control & Prevent, Minist Hlth & Welf, Seoul 122701, South Korea. RP Lee, HW (reprint author), Univ Florida, Dept Pathol, J-566,1600 SW Archer Rd, Gainesville, FL 32610 USA. EM rainlee67@yahoo.co.kr RI LEE, Jong-koo/E-4166-2012; Lee, JongGu/B-7384-2013 FU Korea National Institute of Health, Republic of Korea FX We are grateful to all blood donors. This work was supported by an internal research grant from Korea National Institute of Health, Republic of Korea. NR 32 TC 5 Z9 5 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 18 PY 2010 VL 9 AR 331 DI 10.1186/1475-2875-9-331 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 724UF UT WOS:000287601000002 PM 21087471 ER PT J AU Dong, LB Turgman-Cohen, S Roberts, GW Kiserow, DJ AF Dong, Laura Beth Turgman-Cohen, Salomon Roberts, George W. Kiserow, Douglas J. TI Effect of Polymer Size on Heterogeneous Catalytic Polystyrene Hydrogenation SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID COMPETITIVE ADSORPTION; DIFFUSION; SURFACE; LIQUIDS; SPHERES; SILICA; PORES AB The effect of polymer coil size on the rate of polystyrene (PS) hydrogenation was studied in a slurry reactor with mixtures of decahydronaphthalene (DHN) and carbon dioxide (CO(2)) as the solvent for the polymer. The PS coil size was changed by varying the polymer molecular weight from 9300 g/mol to 357 000 g/mol and by varying the CO(2) concentration. Using a 5% Pd/5% Ru/SiO(2) catalyst, the rate of aromatic ring hydrogenation at 150 degrees C was found to be strongly dependent on the size of a polymer coil relative to the average pore diameter of the catalyst. Significant pore diffusion limitations, as indicated by values of the Weisz modulus, were observed with increasing polymer molecular weight. Increasing the concentration of CO(2) resulted in increased reaction rates, with an improvement of nearly 2 orders of magnitude at the highest PS molecular weight. C1 [Dong, Laura Beth; Turgman-Cohen, Salomon; Roberts, George W.; Kiserow, Douglas J.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Kiserow, Douglas J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dong, LB (reprint author), Albemarle Corp, Baton Rouge, LA USA. EM laura.beth.dong@albemarle.com OI Turgman-Cohen, Salomon/0000-0002-4011-2555 FU United States Army Research Office, Research Triangle Park, NC [W911NF-04-D-0003]; National Science Foundation [CHE-9876674] FX The authors would like to thank BASF Catalysts, LLC for supplying the 5% Pd/5% Ru/SiO2 catalyst used in this work. This research was supported by Contract W911NF-04-D-0003 from the United States Army Research Office, Research Triangle Park, NC. Partial support was also provided by the STC Program of the National Science Foundation under Agreement No. CHE-9876674. NR 30 TC 6 Z9 7 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD NOV 17 PY 2010 VL 49 IS 22 BP 11280 EP 11286 DI 10.1021/ie1011905 PG 7 WC Engineering, Chemical SC Engineering GA 676MT UT WOS:000283916700019 ER PT J AU Peterson, GW Wagner, GW Keller, JH Rossin, JA AF Peterson, Gregory W. Wagner, George W. Keller, Jennifer H. Rossin, Joseph A. TI Enhanced Cyanogen Chloride Removal by the Reactive Zirconium Hydroxide Substrate SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID ADSORPTION; CARBON; DECOMPOSITION; WHETLERITE AB A novel microporous sorbent consisting of zirconium hydroxide impregnated with triethylenediamine (TEDA) was evaluated for the removal of cyanogen chloride. Breakthrough data were collected on packed beds, illustrating the efficacious nature of TEDA and the enhanced cyanogen chloride removal from the basic zirconium hydroxide structure. NMR and XPS analyses revealed the fate of cyanogen chloride, with inorganic chloride byproducts deposited on the surface of the material and polymerized urea condensates physically adsorbed in the pore structure. The zirconium hydroxide media were found to provide significantly enhanced removal capabilities as compared to traditionally impregnated activated carbons, allowing for the development of respirators with reduced encumbrance. C1 [Peterson, Gregory W.; Wagner, George W.] USA, RDCB DRP F, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43016 USA. [Keller, Jennifer H.] SAIC Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Peterson, GW (reprint author), USA, RDCB DRP F, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gregory.w.peterson@us.army.mil FU Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) [BA07PRO104] FX The authors thank the Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) for funding this work under Project BA07PRO104. NR 18 TC 19 Z9 19 U1 2 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD NOV 17 PY 2010 VL 49 IS 22 BP 11182 EP 11187 DI 10.1021/ie101204e PG 6 WC Engineering, Chemical SC Engineering GA 676MT UT WOS:000283916700006 ER PT J AU Nicolaus, M Gerland, S Hudson, SR Hanson, S Haapala, J Perovich, DK AF Nicolaus, Marcel Gerland, Sebastian Hudson, Stephen R. Hanson, Susanne Haapala, Jari Perovich, Donald K. TI Seasonality of spectral albedo and transmittance as observed in the Arctic Transpolar Drift in 2007 SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID 1ST-YEAR SEA-ICE; OPTICAL-PROPERTIES; LIGHT-ABSORPTION; SNOW; SURFACE; PARAMETERIZATION; VARIABILITY; EVOLUTION; RADIATION; SUMMER AB The first continuous and high temporal resolution record of spectral albedo and transmittance of snow and sea ice in the Arctic Ocean over an entire summer season is presented. Measurements were performed at a manned station on multiyear sea ice in the Transpolar Drift during the drift of the schooner Tara from April to September 2007. Concurrent autonomous measurements of ice mass balance and weekly observations of snow and sea-ice properties complement the data set. The seasonality of physical and biological processes of snow and sea ice is characterized, including quantification of melt onset (10 June), melt season duration, and freeze onset (15 August). Over one year, approximately two thirds of the transmitted energy reached the ocean during the 66-day-long melt season. During the second half of July, transmitted irradiance decreased by 90% and absorption in and directly under the ice increased, significantly affecting the vertical partitioning of irradiance. The spectral radiation time series suggests that high biomass abundance in or below the sea ice caused this decrease. Comparing the spectral data set with broadband albedo data measured at the same location shows that 90% of the temporal variability of broadband albedo can be explained by variability in spectral albedo integrated over the limited wavelength range. The combination of spectral radiation and ice mass balance measurements allows a comprehensive description, and quantification, of snow and sea-ice processes, even with minimal additional in situ observations, suggesting such data sets can be collected autonomously to provide insight into the physical and biological processes on sea ice. C1 [Nicolaus, Marcel; Gerland, Sebastian; Hudson, Stephen R.] Norwegian Polar Res Inst, Polar Environm Ctr, N-9296 Tromso, Norway. [Haapala, Jari] Finnish Meteorol Inst, Helsinki 00560, Finland. [Hanson, Susanne] Danish Meteorol Inst, DK-2100 Copenhagen, Denmark. [Perovich, Donald K.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Nicolaus, M (reprint author), Alfred Wegener Inst Polar & Marine Res, Bussestr 24, D-27570 Bremerhaven, Germany. EM marcel.nicolaus@awi.de OI Nicolaus, Marcel/0000-0003-0903-1746 FU Tara Arctic project; European Union; Research Council of Norway [192516, 176096/S30]; IPY; Norwegian Polar Institute and its Centre for Ice, Climate, and Ecosystems (ICE) FX We strongly acknowledge the support of the Tara Arctic project, which enabled these measurements in the high Arctic, and especially thank the Tara summer crew for maintaining the radiation station and performing all additional snow and sea-ice measurements. Great thanks to Timo Palo (University of Tartu, Estonia, and Tara crew), who performed most of the measurements and was heavily involved in all in situ observations, including documentation and photography. Furthermore, we are grateful to all other colleagues who supported our field measurements at Tara with a lot of helping hands. We thank Timo Vihma (Finnish Meteorological Institute) and the University of Tartu for providing the meteorological and broadband irradiance data and for fruitful discussions about these data sets. Stephen Warren (University of Washington, USA) and one anonymous reviewer gave most constructive comments, helping us improving the manuscript. We greatly appreciate their contribution. Anja Nicolaus helped preparing the thin sections of the ice core. This study was funded through the Developing Arctic Modeling and Observing Capabilities for Long-Term Environmental Studies (DAMOCLES) project, which is financed by the European Union. Manuscript preparation was supported though a Leiv Eiriksson stipend from the Research Council of Norway (project 192516) for Marcel Nicolaus. Additional funding was received from the IPY project iAOOS Norway-Closing the Loop, the Research Council of Norway (grant 176096/S30), and the internal funds of the Norwegian Polar Institute and its Centre for Ice, Climate, and Ecosystems (ICE). NR 63 TC 39 Z9 41 U1 2 U2 21 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD NOV 16 PY 2010 VL 115 AR C11011 DI 10.1029/2009JC006074 PG 21 WC Oceanography SC Oceanography GA 683NS UT WOS:000284483100001 ER PT J AU Kranzusch, PJ Schenkb, AD Rahmeh, AA Radoshitzky, SR Bavari, S Walz, T Whelan, SPJ AF Kranzusch, Philip J. Schenk, Andreas D. Rahmeh, Amal A. Radoshitzky, Sheli R. Bavari, Sina Walz, Thomas Whelan, Sean P. J. TI Assembly of a functional Machupo virus polymerase complex SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE segmented negative-strand RNA virus; L protein structure; RNA binding; electron microscopy ID VESICULAR STOMATITIS-VIRUS; NUCLEOPROTEIN-RNA COMPLEX; CRYSTAL-STRUCTURE; GENOME REPLICATION; TACARIBE VIRUS; VIRION RNA; IN-VITRO; 5 ENDS; MECHANISM; ARENAVIRUS AB Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonuclease that cleaves capped primers from cellular mRNAs to prime transcription. Using purified catalytically active Machupo virus L, we provide a view of the overall architecture of this multifunctional polymerase and reconstitute complex formation with an RNA template in vitro. The L protein contains a central ring domain that is similar in appearance to the RdRP of dsRNA viruses and multiple accessory appendages that may be responsible for 5' cap formation. RNA template recognition by L requires a sequence-specific motif located at positions 2-5 in the 3' terminus of the viral genome. Moreover, L-RNA complex formation depends on single-stranded RNA, indicating that inter-termini dsRNA interactions must be partially broken for complex assembly to occur. Our results provide a model for arenavirus polymerase-template interactions and reveal the structural organization of a negative-strand RNA virus L protein. C1 [Kranzusch, Philip J.; Rahmeh, Amal A.; Whelan, Sean P. J.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA. [Schenk, Andreas D.; Walz, Thomas] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA. [Walz, Thomas] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA. [Radoshitzky, Sheli R.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Whelan, SPJ (reprint author), Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA. EM sean_whelan@hms.harvard.edu FU National Institutes of Health [AI057159, AI059371]; Burroughs Wellcome Investigators Award; Swiss National Science Foundation; Defense Threat Reduction Agency, JSTO-CBD [4.10022_08_RD_B, TMTI0048_09_RD_T] FX This study was supported by National Institutes of Health Grants AI057159 and AI059371. S.P.J.W. is a recipient of a Burroughs Wellcome Investigators Award, A.D.S. is supported by a fellowship from the Swiss National Science Foundation, and T.W. is a Howard Hughes Medical Institute Investigator. We acknowledge the exceptional support by Robin Ross and Lauren Perry (New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases). A portion of the research described herein was sponsored by the Defense Threat Reduction Agency, JSTO-CBD (project number 4.10022_08_RD_B and TMTI0048_09_RD_T to S. B.). NR 38 TC 30 Z9 30 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 16 PY 2010 VL 107 IS 46 BP 20069 EP 20074 DI 10.1073/pnas.1007152107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 680UT UT WOS:000284261800084 PM 20978208 ER PT J AU Fellows, P Adamovicz, J Hartings, J Sherwood, R Mega, W Brasel, T Barr, E Holland, L Lin, W Rom, A Blackwelder, W Price, J Morris, S Snow, D Hart, MK AF Fellows, Patricia Adamovicz, Jeffrey Hartings, Justin Sherwood, Robert Mega, William Brasel, Trevor Barr, Ed Holland, Lou Lin, Winston Rom, Amanda Blackwelder, William Price, Jessica Morris, Stephen Snow, Doris Hart, Mary Kate TI Protection in mice passively immunized with serum from cynomolgus macaques and humans vaccinated with recombinant plague vaccine (rF1V) SO VACCINE LA English DT Article DE Yersinia pestis; Passive transfer; rF1V vaccine; Pneumonic plague ID PNEUMONIC PLAGUE; YERSINIA-PESTIS; SUBUNIT VACCINE; MONOCLONAL-ANTIBODIES; V-ANTIGEN; EFFICACY; PROTEIN; F1; IMMUNOGENICITY; INFECTION AB Passive transfer models were developed to evaluate the ability of antibodies generated in cynomolgus macaques and humans vaccinated with a recombinant plague vaccine (rF1V) to protect naive Swiss Webster mice against pneumonic plague. Development of the passive transfer model is intended to support clinical and nonclinical development of the rF1V vaccine. To evaluate protection, unfractionated serum collected from rF1V vaccinated cynomolgus macaques and human volunteers with known antibody titers to rF1, rV and rF1V was transferred into naive Swiss Webster mice via the intraperitoneal route. Results of these studies demonstrated that passive immunization protected mice from challenge or extended mean survival time and that the passive transfer assay can be used to evaluate the functional role of antibodies induced by rF1V vaccination in protection against aerosol exposure. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Fellows, Patricia; Price, Jessica; Morris, Stephen; Snow, Doris; Hart, Mary Kate] CSC Co, DynPort Vaccine Co, Frederick, MD 21702 USA. [Adamovicz, Jeffrey] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Adamovicz, Jeffrey] Midwest Res Inst, Frederick, MD 21702 USA. [Hartings, Justin] Biaera Technol LLC, Frederick, MD 21704 USA. [Sherwood, Robert; Mega, William; Brasel, Trevor; Barr, Ed] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. [Holland, Lou; Lin, Winston; Rom, Amanda] IIT, Res Inst, Chicago, IL 60616 USA. [Blackwelder, William] Biol Consulting Grp LLC, Alexandria, VA USA. [Morris, Stephen] US Dept HHS, BARDA, Washington, DC 20201 USA. RP Fellows, P (reprint author), CSC Co, DynPort Vaccine Co, 64 Thomas Johnson Dr, Frederick, MD 21702 USA. EM pfellows@csc.com FU Chemical Biological Medical Systems-Joint Vaccine Acquisition Program (CBMS/JVAP) [DAMD 17-98-C8024] FX This study was supported by the Chemical Biological Medical Systems-Joint Vaccine Acquisition Program (CBMS/JVAP) Contract DAMD 17-98-C8024. The current development effort for the rF1V vaccine is supported by an international partnering arrangement that includes the United Kingdom and Canada. The facilities performing the passive transfer model development studies are fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International. Human sera were collected under a research protocol approved by the USAMRMC Human Subjects Research Review Board and as part of an IRB- and HSRRB-approved clinical study titled, "A Phase 2(a), Dose-blinded, Block-Randomized Dose and Schedule Selection Study to Evaluate the Immunogenicity and Safety of the Recombinant Plague Vaccine rF1V in Healthy Volunteers" [Protocol rFV-02(a)]. NR 40 TC 14 Z9 15 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 16 PY 2010 VL 28 IS 49 BP 7748 EP 7756 DI 10.1016/j.vaccine.2010.09.062 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 697PD UT WOS:000285526300007 PM 20920572 ER PT J AU Taylor, PJ Sarney, W Swaminathan, V AF Taylor, P. J. Sarney, W. Swaminathan, V. TI Formation of periodic nanotube array through the Kirkendall effect in epitaxial heterostructures SO APPLIED PHYSICS LETTERS LA English DT Article AB The spontaneous formation of hollow nanotubes at the heteroepitaxial interface between near lattice-matched PbSe and ZnTe is reported. Mass-spectroscopy measurements show that the rapid diffusion of zinc into PbSe, and reduced diffusion of Pb outward, governs the formation of the nanotubes by a Kirkendall vacancy-condensation mechanism. High-resolution electron microscopy shows that the diameter of the tubes ranges from 10 to 100 nm, and the spacing between neighboring nanotubes is consistent with the equilibrium spacing of misfit dislocations, suggesting that the strain field of misfit dislocations acts as the nucleation site of the nanotubes. [doi: 10.1063/1.3516471] C1 [Taylor, P. J.; Sarney, W.] USA, Res Lab, Sensors & Electron Devices Directorate, Attn RDRL SEE I, Adelphi, MD 20783 USA. [Swaminathan, V.] USA, Armament Res Dev Engn Command, Attn RDAR MEF A, Picatinny Arsenal, NJ 07806 USA. RP Taylor, PJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Attn RDRL SEE I, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM patrick.taylor7@us.army.mil NR 6 TC 1 Z9 1 U1 1 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 15 PY 2010 VL 97 IS 20 AR 203105 DI 10.1063/1.3516471 PG 2 WC Physics, Applied SC Physics GA 684JC UT WOS:000284545200053 ER PT J AU Canis, L Linkov, I Seager, TP AF Canis, Laure Linkov, Igor Seager, Thomas P. TI Application of Stochastic Multiattribute Analysis to Assessment of Single Walled Carbon Nanotube Synthesis Processes SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LIFE-CYCLE ASSESSMENT; DECISION-ANALYSIS AB The unprecedented uncertainty associated with engineered nanomaterials greatly expands the need for research regarding their potential environmental consequences. However, decision-makers such as regulatory agencies, product developers, or other nanotechnology stakeholders may not find the results of such research directly informative of decisions intended to mitigate environmental risks. To help interpret research findings and prioritize new research needs, there is an acute need for structured decision-analytic aids that are operable in a context of extraordinary uncertainty. Whereas existing stochastic decision-analytic techniques explore uncertainty only in decision-maker preference information, this paper extends model uncertainty to technology performance. As an illustrative example, the framework is applied to the case of single-wall carbon nanotubes. Four different synthesis processes (arc, high pressure carbon monoxide, chemical vapor deposition, and laser) are compared based on five salient performance criteria. A probabilistic rank ordering of preferred processes is determined using outranking normalization and a linear-weighted sum for different weighting scenarios including completely unknown weights and four fixed-weight sets representing hypothetical stakeholder views. No single process pathway dominates under all weight scenarios, but it is likely that some inferior process technologies could be identified as low priorities for further research. C1 [Canis, Laure; Linkov, Igor] USA, Corps Engineers, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Seager, Thomas P.] Arizona State Univ, Ctr Earth Syst Engn & Management, Sch Sustainable Engn & Built Environm, Ira A Fulton Sch Engn, Tempe, AZ 85287 USA. RP Linkov, I (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil NR 29 TC 19 Z9 23 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2010 VL 44 IS 22 BP 8704 EP 8711 DI 10.1021/es102117k PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 680QA UT WOS:000284248300055 PM 20964398 ER PT J AU Yin, BJ Ma, G Yen, CY Zhou, ZP Wang, GX Divino, CM Casares, S Chen, SH Yang, WC Pan, PY AF Yin, Bingjiao Ma, Ge Yen, Chun-Yu Zhou, Zuping Wang, George X. Divino, Celia M. Casares, Sofia Chen, Shu-Hsia Yang, Wen-Chin Pan, Ping-Ying TI Myeloid-Derived Suppressor Cells Prevent Type 1 Diabetes in Murine Models SO JOURNAL OF IMMUNOLOGY LA English DT Article ID REGULATORY T-CELLS; IMMUNE TOLERANCE; DISEASE; MICE; RECEPTOR; COSTIMULATION; PATHOGENESIS; MECHANISMS; EXPANSION; MEDIATE AB Effective immunotherapy for type 1 diabetes (T1D) relies on active induction of peripheral tolerance. Myeloid-derived suppressor cells (MDSCs) play a critical role in suppressing immune responses in various pathologic settings via multiple mechanisms, including expansion of regulatory T cells (Tregs). In this study, we investigated whether MDSCs could act as APCs to induce expansion of Ag-specific Tregs, suppress T cell proliferation, and prevent autoimmune T1D development. We found that MDSC-mediated expansion of Tregs and T cell suppression required MHC-dependent Ag presentation. A murine T1D model was established in INS-HA/RAG(-/-) mice in which animals received CD4-HA-TCR transgenic T cells via adoptive transfer. We found a significant reduction in the incidence of diabetes in recipients receiving MDSC plus HA, but not OVA peptide, leading to 75% diabetes-free mice among the treated animals. To test further whether MDSCs could prevent diabetes onset in NOD mice, nondiabetic NOD/SCID mice were injected with inflammatory T cells from diabetic NOD mice. MDSCs significantly prevented diabetes onset, and 60% of MDSC-treated mice remained diabetes free. The pancreata of treated mice showed significantly lower levels of lymphocyte infiltration in islet and less insulitis compared with that of the control groups. The protective effects of MDSCs might be mediated by inducing anergy in autoreactive T cells and the development of CD4(+) CD25(+) Foxp3(+) Tregs. Thist study demonstrates a remarkable capacity of transferred MDSCs to downregulate Ag-specific autoimmune responses and prevent diabetes onset, suggesting that MDSCs possess great potential as a novel cell-based tolerogenic therapy in the control of T1D and other autoimmune diseases. The Journal of Immunology, 2010, 185: 5828-5834. C1 [Yin, Bingjiao; Ma, Ge; Zhou, Zuping; Wang, George X.; Chen, Shu-Hsia; Pan, Ping-Ying] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA. [Chen, Shu-Hsia] Mt Sinai Sch Med, Dept Gen Surg, New York, NY 10029 USA. [Yen, Chun-Yu; Divino, Celia M.; Yang, Wen-Chin] Acad Sinica, Agr Biotechnol Res Ctr, Taipei, Taiwan. [Yen, Chun-Yu; Yang, Wen-Chin] Natl Taiwan Univ, Inst Zool, Taipei 10764, Taiwan. [Casares, Sofia] USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program,Infect Dis Directo, Silver Spring, MD 20920 USA. RP Chen, SH (reprint author), Mt Sinai Sch Med, Dept Gene & Cell Med, Box 1496,1 Gustave L Levy Pl, New York, NY 10029 USA. EM shu-hisa.chen@mssm.edu; wcyang@gate.sinica.edu.tw; ping-ying.pan@mssm.edu RI Yang, Wen-Chin/D-3441-2015 FU National Cancer Institute [CA70337, CA109322, DK073603]; Black Family Stem Cell Foundation FX This work was supported in part by National Cancer Institute RO1 Grants CA70337, CA109322, and DK073603 and by a grant from Black Family Stem Cell Foundation. NR 29 TC 70 Z9 79 U1 0 U2 4 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 2010 VL 185 IS 10 BP 5828 EP 5834 DI 10.4049/jimmunol.0903636 PG 7 WC Immunology SC Immunology GA 675RJ UT WOS:000283848000020 PM 20956337 ER PT J AU Koehler, RN Walsh, AM Saathoff, E Tovanabutra, S Arroyo, MA Currier, JR Maboko, L Hoelsher, M Robb, ML Michael, NL McCutchan, FE Kim, JH Kijak, GH AF Koehler, Rebecca N. Walsh, Anne M. Saathoff, Elmar Tovanabutra, Sodsai Arroyo, Miguel A. Currier, Jeffery R. Maboko, Leonard Hoelsher, Michael Robb, Merlin L. Michael, Nelson L. McCutchan, Francine E. Kim, Jerome H. Kijak, Gustavo H. TI Class I HLA-A(star)7401 Is Associated with Protection from HIV-1 Acquisition and Disease Progression in Mbeya, Tanzania SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ANTIGEN CLASS-I; VIRAL LOAD; HLA; SUPERTYPES; DIVERSITY; INFECTION; REGION AB Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV1 infection, remains understudied. African-specific allele HLA-A(star)74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4(+) cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A(star)74:01 may influence HIV-1 acquisition and control of the infection. C1 [Koehler, Rebecca N.; Walsh, Anne M.; Tovanabutra, Sodsai; Currier, Jeffery R.; Robb, Merlin L.; McCutchan, Francine E.; Kijak, Gustavo H.] US Mil HIV Res Program, Henry M Jackson Fdn, Rockville, MD 20850 USA. [Arroyo, Miguel A.; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Saathoff, Elmar; Hoelsher, Michael] Univ Munich, Dept Infect Dis & Trop Med, D-80539 Munich, Germany. [Maboko, Leonard; Hoelsher, Michael] Mbeya Med Res Program, Mbeya, Tanzania. RP Kijak, GH (reprint author), US Mil HIV Res Program, Henry M Jackson Fdn, 1600 E Gude Dr, Rockville, MD 20850 USA. EM gkijak@hivresearch.org RI Hoelscher, Michael/D-3436-2012; OI Arroyo, Miguel/0000-0001-7416-8867 FU Henry M. Jackson Foundation for the Advancement of Military Medicine; US Department of Defense; National Institute for Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH) [Y01 AI2642-12]; DOD; NIAID/NIH FX This work was supported through a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense, by the National Institute for Allergy and Infectious Diseases (NIAID), and National Institutes of Health (NIH) (grant Y01 AI2642-12).; The US Military HIV Research Program is jointly planned and funded by the DOD and NIAID/NIH by an interagency agreement. This manuscript was approved for publication by the Walter Reed Army Institute of Research. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the US Army or the Department of Defense or the National Institutes of Health. NR 15 TC 21 Z9 21 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2010 VL 202 IS 10 BP 1562 EP 1566 DI 10.1086/656913 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 665SY UT WOS:000283057000015 PM 20923372 ER PT J AU Grujicic, M Pandurangan, B He, T Cheeseman, BA Yen, CF Randow, CL AF Grujicic, M. Pandurangan, B. He, T. Cheeseman, B. A. Yen, C. -F. Randow, C. L. TI Computational investigation of impact energy absorption capability of polyurea coatings via deformation-induced glass transition SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Polyurea; Computational analysis; Glass transition; Blast/impact energy absorption coating ID THIN PLATES; FRACTURE PREDICTION; PRESSURE; MODEL AB A number of experimental investigations reported in the open literature have indicated that the application of polyurea coatings can substantially improve blast and ballistic impact resistance/survivability of buildings, vehicles and laboratory test plates. While several potential mechanisms (e.g., shock-impedance mismatch, shock-wave dispersion, fracture-mode conversion and strain delocalization) have been proposed for the observed enhancement in the blast-wave/projectile-energy absorption, direct experimental or analytical evidence for the operation of these mechanisms has been lacking. Recently, it has been proposed that transition of polyurea between its rubbery-state and its glassy-state under high deformation-rate loading conditions is another possible mechanism for the improved ballistic impact resistance of polyurea-coated structures/test plates. In the present work, an attempt is made to provide computational support for this deformation-induced glass transition based energy-dissipation/absorption mechanism. Towards that end, a series of finite-element analyses of the projectile/coated-plate interactions are carried out using a transient non-linear dynamics finite-element approach. The results obtained are used to assess the extent of energy absorption and to identify the mode of failure of the test plate as a function of the imposed impact conditions. The results obtained show that the mechanical response of polyurea under impact conditions is a fairly sensitive function of the difference between the test temperature and the glass transition temperature. Specifically, when this difference is large, polyurea tends to display high-ductility behavior of a stereotypical elastomer in its rubbery-state. On the other hand, when the test temperature is closer to the glass transition temperature, polyurea tends to transform into its glassy-state during deformation and this process is associated with viscous type energy-dissipation. It is also argued that additional energy absorbing/dissipating mechanisms may contribute to the superior ballistic/blast protection capability of polyurea. (C) 2010 Elsevier B.V. All rights reserved. C1 [Grujicic, M.; Pandurangan, B.; He, T.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Yen, C. -F.; Randow, C. L.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU Pennsylvania State University [4036-CU-ONR-1125]; Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory (ARL) [W911NF-06-2-0042] FX The material presented in this paper is based on work supported by the Office of Naval Research (ONR) research contract entitled "Elastomeric Polymer-By-Design to Protect the Warfighter Against Traumatic Brain Injury by Diverting the Blast Induced Shock Waves from the Head", Contract Number 4036-CU-ONR-1125 as funded through the Pennsylvania State University, the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites", Contract Number W911NF-09-1-0513, and the Army Research Laboratory (ARL) research contract entitled "Computational Analysis and Modeling of Various Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil" Contract Number W911NF-06-2-0042. The authors are indebted to Drs. Roshdy Barsoum of ONR and Bruce LaMat-tina of ARO for their continuing support and interest in the present work. The authors also want to thank professors J. Runt, J. Tarter, G. Settles, G. Dillon and M. Hargether for stimulating discussions and friendship. NR 30 TC 58 Z9 60 U1 9 U2 29 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 15 PY 2010 VL 527 IS 29-30 BP 7741 EP 7751 DI 10.1016/j.msea.2010.08.042 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 676EJ UT WOS:000283892600037 ER PT J AU Zainuddin, S Hosur, MV Zhou, Y Narteh, AT Kumar, A Jeelani, S AF Zainuddin, S. Hosur, M. V. Zhou, Y. Narteh, Alfred T. Kumar, Ashok Jeelani, S. TI Experimental and numerical investigations on flexural and thermal properties of nanoclay-epoxy nanocomposites SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Nanoclay; Nanocomposites; Thermo-mechanical properties; Weibull parameters ID LAYERED SILICATE NANOCOMPOSITES; CLAY NANOCOMPOSITES; BARRIER PROPERTIES; GAS PERMEATION; BEHAVIOR; COMPOSITES; MORPHOLOGY AB The prime aim of this investigation is to study the effect of montmorillonite nanoclay on mechanical and thermal properties and to develop a non-linear damage model to describe the stress-strain relationship of epoxy resin system. Neat and nanocomposites with 1-3 wt.% clay loading were fabricated. Dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA) and three-point bend tests were carried out to evaluate thermo-mechanical and mechanical properties. Results demonstrated optimum enhancement in 2 wt.% doped system in both thermal and mechanical properties when compared to the neat system. X-ray diffraction (XRD) and transmission electron microscopy (TEM) results indicated mixed intercalation and exfoliation of clay platelets in 2 wt.% system. Scanning electron micrographs (SEM) of 2 wt.% samples showed rougher fracture surface in comparison to neat epoxy samples. Based on the experimental results, a non-linear damage model using flexural modulus and Weibull parameters was established to describe the stress-strain relationship. These simulated strain-strain relationship coordinated well with the experimental results and show that the Weibull scale parameter, sigma(0), increased whereas the Weibull shape parameter, beta, remained insensitive with increasing clay content. (c) 2010 Elsevier B.V. All rights reserved. C1 [Zainuddin, S.; Hosur, M. V.; Zhou, Y.; Narteh, Alfred T.; Jeelani, S.] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Kumar, Ashok] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Hosur, MV (reprint author), Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. EM hosur@tuskegee.edu FU U.S. Engineer Research Development Corporation - Construction Engineering Research Laboratory (ERDC-CERL) FX The authors would like to acknowledge U.S. Engineer Research Development Corporation - Construction Engineering Research Laboratory (ERDC-CERL) for funding this work. NR 27 TC 31 Z9 31 U1 2 U2 12 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 15 PY 2010 VL 527 IS 29-30 BP 7920 EP 7926 DI 10.1016/j.msea.2010.08.078 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 676EJ UT WOS:000283892600061 ER PT J AU Currier, JR Ngauy, V de Souza, MS Ratto-Kim, S Cox, JH Polonis, VR Earl, P Moss, B Peel, S Slike, B Sriplienchan, S Thongcharoen, P Paris, RM Robb, ML Kim, J Michael, NL Marovich, MA AF Currier, Jeffrey R. Ngauy, Viseth de Souza, Mark S. Ratto-Kim, Silvia Cox, Josephine H. Polonis, Victoria R. Earl, Patricia Moss, Bernard Peel, Sheila Slike, Bonnie Sriplienchan, Somchai Thongcharoen, Prasert Paris, Robert M. Robb, Merlin L. Kim, Jerome Michael, Nelson L. Marovich, Mary A. TI Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RESPONSES; HIV-1 VACCINE; BOOST VACCINE; SMALLPOX VACCINATION; IMMUNE-RESPONSES; SUBTYPE-B; NYVAC-C; DNA; PRIME AB Background: We conducted a Phase I randomized, dose-escalation, route-comparison trial of MVA-CMDR, a candidate HIV-1 vaccine based on a recombinant modified vaccinia Ankara viral vector expressing HIV-1 genes env/gag/pol. The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand. Methodology/Principal Findings: MVA-CMDR or placebo was administered intra-muscularly (IM; 10(7) or 10(8) pfu) or intradermally (ID; 10(6) or 10(7) pfu) at months 0, 1 and 3, to 48 healthy volunteers at low risk for HIV-1 infection. Twelve volunteers in each dosage group were randomized to receive MVA-CMDR or placebo (10: 2). Volunteers were actively monitored for local and systemic reactogenicity and adverse events post vaccination. Cellular immunogenicity was assessed by a validated IFN gamma Elispot assay, an intracellular cytokine staining assay, lymphocyte proliferation and a Cr-51-release assay. Humoral immunogenicity was assessed by ADCC for gp120 and binding antibody ELISAs for gp120 and p24. MVA-CMDR was safe and well tolerated with no vaccine related serious adverse events. Cell-mediated immune responses were: (i) moderate in magnitude (median IFN gamma Elispot of 78 SFC/10(6) PBMC at 10(8) pfu IM), but high in response rate (70% Cr-51-release positive; 90% Elispot positive; 100% ICS positive, at 10(8) pfu IM); (ii) predominantly HIV Env-specific CD4(+) T cells, with a high proliferative capacity and durable for at least 6 months (100% LPA response rate by the IM route); (iv) dose- and route-dependent with 10(8) pfu IM being the most immunogenic treatment. Binding antibodies against gp120 and p24 were detectable in all vaccination groups with ADCC capacity detectable at the highest dose (40% positive at 10(8) pfu IM). Conclusions/Significance: MVA-CMDR delivered both intramuscularly and intradermally was safe, well-tolerated and elicited durable cell-mediated and humoral immune responses. C1 [Currier, Jeffrey R.; Ratto-Kim, Silvia; Polonis, Victoria R.; Peel, Sheila; Slike, Bonnie; Robb, Merlin L.; Kim, Jerome; Michael, Nelson L.; Marovich, Mary A.] US Mil HIV Res Program, Rockville, MD USA. [Ngauy, Viseth; de Souza, Mark S.; Sriplienchan, Somchai; Paris, Robert M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Cox, Josephine H.] Int AIDS Vaccine Initiat, New York, NY USA. [Earl, Patricia; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Thongcharoen, Prasert] Mahidol Univ, Bangkok 10700, Thailand. RP Currier, JR (reprint author), US Mil HIV Res Program, Rockville, MD USA. EM jcurrier@hivresearch.org FU U.S. Army Medical Research and Materiel Command [W81XWH-04-02-0005]; Henry M. Jackson Foundation for the Advancement of Military Medicine FX This work was supported by the U.S. Army Medical Research and Materiel Command and its Cooperative Agreement (W81XWH-04-02-0005) with the Henry M. Jackson Foundation for the Advancement of Military Medicine. The opinions expressed herein are those of the authors and do not represent the official position of the U. S. Army or Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 51 Z9 51 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 15 PY 2010 VL 5 IS 11 AR e13983 DI 10.1371/journal.pone.0013983 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 680KW UT WOS:000284231800013 PM 21085591 ER PT J AU Deng, YP Johnson, DR Guan, X Ang, CY Ai, JM Perkins, EJ AF Deng, Youping Johnson, David R. Guan, Xin Ang, Choo Y. Ai, Junmei Perkins, Edward J. TI In vitro gene regulatory networks predict in vivo function of liver SO BMC SYSTEMS BIOLOGY LA English DT Article ID EXPRESSION PROFILES; HEMOGLOBIN ADDUCTS; EISENIA-FOETIDA; T-LYMPHOCYTES; DNA-DAMAGE; 2,4,6-TRINITROTOLUENE; CELLS; TOXICITY; MICE; IDENTIFICATION AB Background: Evolution of toxicity testing is predicated upon using in vitro cell based systems to rapidly screen and predict how a chemical might cause toxicity to an organ in vivo. However, the degree to which we can extend in vitro results to in vivo activity and possible mechanisms of action remains to be fully addressed. Results: Here we use the nitroaromatic 2,4,6-trinitrotoluene (TNT) as a model chemical to compare and determine how we might extrapolate from in vitro data to in vivo effects. We found 341 transcripts differentially expressed in common among in vitro and in vivo assays in response to TNT. The major functional term corresponding to these transcripts was cell cycle. Similarly modulated common pathways were identified between in vitro and in vivo. Furthermore, we uncovered the conserved common transcriptional gene regulatory networks between in vitro and in vivo cellular liver systems that responded to TNT exposure, which mainly contain 2 subnetwork modules: PTTG1 and PIR centered networks. Interestingly, all 7 genes in the PTTG1 module were involved in cell cycle and downregulated by TNT both in vitro and in vivo. Conclusions: The results of our investigation of TNT effects on gene expression in liver suggest that gene regulatory networks obtained from an in vitro system can predict in vivo function and mechanisms. Inhibiting PTTG1 and its targeted cell cyle related genes could be key machanism for TNT induced liver toxicity. C1 [Deng, Youping] Rush Univ Med Ctr, Rush Univ Canc Ctr, Chicago, IL 60612 USA. [Johnson, David R.; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Guan, Xin; Ang, Choo Y.] SpecPro Inc, Vicksburg, MS 39180 USA. [Ai, Junmei] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. RP Deng, YP (reprint author), Rush Univ Med Ctr, Rush Univ Canc Ctr, Chicago, IL 60612 USA. EM youping_deng@rush.edu FU United States Army Engineer Research and Development Center [W912HZ-05-P-0145] FX We thank Dr. Sharon Meyer from University of Louisiana at Monroe for supervising animal experiments. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. The tests described and the resulting data presented herein, unless otherwise noted, were supported by research under the Environmental Quality Technology Program (contract #W912HZ-05-P-0145) of the United States Army Engineer Research and Development Center. Permission was granted by the Chief of Engineers to publish this information. NR 69 TC 10 Z9 10 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD NOV 12 PY 2010 VL 4 AR 153 DI 10.1186/1752-0509-4-153 PG 18 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 691EE UT WOS:000285062300001 PM 21073692 ER PT J AU Yao, ZX Jogunoori, W Choufani, S Rashid, A Blake, T Yao, WG Kreishman, P Amin, R Sidawy, AA Evans, SRT Finegold, M Reddy, EP Mishra, B Weksberg, R Kumar, R Mishra, L AF Yao, Zhi-Xing Jogunoori, Wilma Choufani, Sanaa Rashid, Asif Blake, Tiffany Yao, Wenguo Kreishman, Peter Amin, Rupen Sidawy, Anton A. Evans, Stephen R. T. Finegold, Milton Reddy, E. Premkumar Mishra, Bibhuti Weksberg, Rosanna Kumar, Rakesh Mishra, Lopa TI Epigenetic Silencing of beta-Spectrin, a TGF-beta Signaling/Scaffolding Protein in a Human Cancer Stem Cell Disorder BECKWITH-WIEDEMANN SYNDROME SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID GOLABI-BEHMEL-SYNDROME; PERINATAL LETHALITY; IMPRINTED GENES; MOUSE MODEL; GROWTH; MICE; DISRUPTION; P57(KIP2); IGF2; OVERGROWTH AB Hereditary cancer syndromes provide powerful insights into dysfunctional signaling pathways that lead to sporadic cancers. Beckwith-Wiedemann syndrome (BWS) is a hereditary human cancer stem cell syndrome currently linked to deregulated imprinting at chromosome 11p15 and uniparental disomy. However, causal molecular defects and genetic models have remained elusive to date in the majority of cases. The non-pleckstrin homology domain beta-spectrin (beta 2SP) (the official name for human is Spectrin, beta, nonerythrocytic 1 (SPTBN1), isoform 2; the official name for mouse is Spectrin beta 2 (Spnb2), isoform 2), a scaffolding protein, functions as a potent TGF-beta signaling member adaptor in tumor suppression and development. Yet, the role of the beta 2SP in human tumor syndromes remains unclear. Here, we report that beta 2SP(+/-) mice are born with many phenotypic characteristics observed in BWS patients, suggesting that beta 2SP mutant mice phenocopy BWS, and beta 2SP loss could be one of the mechanisms associated with BWS. Our results also suggest that epigenetic silencing of beta 2SP is a new potential causal factor in human BWS patients. Furthermore, beta 2SP(+/-) mice provide an important animal model for BWS, as well as sporadic cancers associated with it, including lethal gastrointestinal and pancreatic cancer. Thus, these studies could lead to further insight into defects generated by dysfunctional stem cells and identification of new treatment strategies and functional markers for the early detection of these lethal cancers that otherwise cannot be detected at an early stage. C1 [Yao, Zhi-Xing; Jogunoori, Wilma; Blake, Tiffany; Yao, Wenguo; Amin, Rupen; Mishra, Bibhuti; Mishra, Lopa] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA. [Rashid, Asif] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA. [Evans, Stephen R. T.] Georgetown Univ, Dept Surg, Washington, DC 20057 USA. [Kumar, Rakesh] George Washington Univ, Dept Biochem & Mol Biol, Washington, DC 20037 USA. [Finegold, Milton] Baylor Univ, Dept Pathol, Houston, TX 77030 USA. [Sidawy, Anton A.] Dept Vet Affairs Med Ctr, Washington, DC 20422 USA. [Reddy, E. Premkumar] Mt Sinai Med Ctr, New York, NY 10029 USA. [Choufani, Sanaa; Weksberg, Rosanna] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Kreishman, Peter] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Mishra, L (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA. EM lmishra@mdanderson.org RI Reddy, E. Premkumar/F-6233-2011 FU National Institutes of Health [P01 CA130821, R01 CA106614A, R01 CA042857, R01 DK58637]; Veterans Affairs merit award; R. Robert and Sally D. Funderburg Research Scholar award FX This work was supported, in whole or in part, by National Institutes of Health Grants P01 CA130821, R01 CA106614A, and R01 CA042857 (to L. M.) and R01 DK58637 (to B. M.). This work was also supported by a Veterans Affairs merit award (to L. M.), the R. Robert and Sally D. Funderburg Research Scholar award (to L. M.) NR 49 TC 14 Z9 17 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 12 PY 2010 VL 285 IS 46 BP 36112 EP 36120 DI 10.1074/jbc.M110.162347 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 675QK UT WOS:000283845300087 PM 20739274 ER PT J AU Crum-Cianflone, NF Roediger, M Hullsiek, KH Ganesan, A Landrum, M Weintrob, A Agan, B Medina, S Rahkola, J Hale, B Janoff, EN AF Crum-Cianflone, Nancy F. Roediger, Mollie Hullsiek, Kathy Huppler Ganesan, Anuradha Landrum, Michael Weintrob, Amy Agan, Brian Medina, Sheila Rahkola, Jeremy Hale, Braden Janoff, Edward N. CA Infect Dis Clinical Res Program HI TI The association of ethnicity with antibody responses to pneumococcal vaccination among adults with HIV infection SO VACCINE LA English DT Article DE Ethnicity; Antibodies; Pneumococcal vaccination; HIV ID IMMUNODEFICIENCY-VIRUS-INFECTION; HIV-1-INFECTED UGANDAN ADULTS; POLYSACCHARIDE VACCINE; RISK-FACTORS; RESISTANCE PATTERNS; CLINICAL-FEATURES; CHARLESTON COUNTY; CONJUGATE VACCINE; SOUTH-CAROLINA; DISEASE AB Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive disease. We evaluated the association of ethnicity with capsule-specific antibody responses to pneumococcal revaccination, with either the pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccines among 188 HIV-infected adults. The proportion of the 77 African Americans (AA) and 111 Caucasians with comparable virologic and immunologic parameters who achieved a positive immune response (>= 2-fold rise in capsule-specific IgG from baseline with post-vaccination value >= 1 mu g/mL for >= 2 of 4 serotypes) at day 60 after revaccination was similar (43% vs. 49%, respectively, p = 0.65). Results were also similar when vaccine types (PPV and PCV) were examined separately. Mean changes in log(10) transformed IgG levels from baseline to days 60 and 180 post-vaccination were also not significantly different between AA and Caucasians. In summary, in this ethnically diverse cohort with equal access to care, we did not observe differential antibody responses between AA and Caucasian HIV-infected adults after pneumococcal revaccination. Published by Elsevier Ltd. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Roediger, Mollie; Hullsiek, Kathy Huppler; Ganesan, Anuradha; Landrum, Michael; Weintrob, Amy; Agan, Brian; Medina, Sheila; Hale, Braden] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Roediger, Mollie; Hullsiek, Kathy Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Landrum, Michael] San Antonio Mil Med Ctr, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rahkola, Jeremy; Janoff, Edward N.] Univ Colorado, Mucosal & Vaccine Res Program Colorado MAVRC, Denver, CO 80202 USA. [Hale, Braden] USN, Hlth Res Ctr, San Diego, CA 92134 USA. [Rahkola, Jeremy; Janoff, Edward N.] Denver Vet Affairs Med Ctr, Denver, CO USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Department of Defense (DoD) through the Uniformed Services University of the Health Sciences [IDCRP RV-150]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Veterans Affairs Research Service FX Support for this work (IDCRP RV-150) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. Additional support was obtained from the Veterans Affairs Research Service. NR 27 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 10 PY 2010 VL 28 IS 48 BP 7583 EP 7588 DI 10.1016/j.vaccine.2010.09.056 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 696HN UT WOS:000285432600002 PM 20887830 ER PT J AU Branco, LM Grove, JN Moses, LM Goba, A Fullah, M Momoh, M Schoepp, RJ Bausch, DG Garry, RF AF Branco, Luis M. Grove, Jessica N. Moses, Lina M. Goba, Augustine Fullah, Mohammed Momoh, Mambu Schoepp, Randal J. Bausch, Daniel G. Garry, Robert F. TI Shedding of soluble glycoprotein 1 detected during acute Lassa virus infection in human subjects SO VIROLOGY JOURNAL LA English DT Article ID EBOLA-VIRUS; PROTEIN-Z; FEVER; PARTICLES; DETERMINANTS; ACTIVATION; ANTIBODIES; RELEASE; CELLS; GP AB Background: Lassa hemorrhagic fever (LHF) is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic. With a high rate of infection that may lead to morbidity and mortality, understanding how the virus interacts with the host's immune system is of great importance for generating vaccines and therapeutics. Previous work by our group identified a soluble isoform of the Lassa virus (LASV) GP1 (sGP1) in vitro resulting from the expression of the glycoprotein complex (GPC) gene [1,2]. Though no work has directly been done to demonstrate the function of this soluble isoform in arenaviral infections, evidence points to immunomodulatory effects against the host's immune system mediated by a secreted glycoprotein component in filoviruses, another class of hemorrhagic fever-causing viruses. A significant fraction of shed glycoprotein isoforms during viral infection and biogenesis may attenuate the host's inflammatory response, thereby enhancing viral replication and tissue damage. Such shed glycoprotein mediated effects were previously reported for Ebola virus (EBOV), a filovirus that also causes hemorrhagic fever with nearly 90% fatality rates [3-5]. The identification of an analogous phenomenon in vivo could establish a new correlate of LHF infection leading to the development of sensitive diagnostics targeting the earliest molecular events of the disease. Additionally, the reversal of potentially untoward immunomodulatory functions mediated by sGP1 could potentiate the development of novel therapeutic intervention. To this end, we investigated the presence of sGP1 in the serum of suspected LASV patients admitted to the Kenema Government Hospital (KGH) Lassa Fever Ward (LFW), in Kenema, Sierra Leone that tested positive for viral antigen or displayed classical signs of Lassa fever. Results: It is reasonable to expect that a narrow window exists for detection of sGP1 as the sole protein shed during early arenaviral biogenesis. This phenomenon was clearly distinguishable from virion-associated GP1 only prior to the emergence of de novo viral particles. Despite this restricted time frame, in 2/46 suspected cases in two studies performed in late 2009 and early 2010, soluble glycoprotein component shedding was identified. Differential detection of viral antigens GP1, GP2, and NP by western blot yielded five different scenarios: whole LASV virions (GP1, GP2, NP; i.e. active viremia), different combinations of these three proteins, sGP1 only, NP only, and absence of all three proteins. Four additional samples showed inconclusive evidence for sGP1 shedding due to lack of detection of GP2 and NP by western blot; however, a sensitive LASV NP antigen capture ELISA generated marginally positive signals Conclusions: During a narrow window following active infection with LASV, soluble GP1 can be detected in patient sera. This phenomenon parallels other VHF infection profiles, with the actual role of a soluble viral glycoprotein component in vivo remaining largely speculative. The expenditure of energy and cellular resources toward secretion of a critical protein during viral biogenesis without apparent specific function requires further investigation. Future studies will be aimed at systematically identifying the role of LASV sGP1 in the infection process and outcome in vitro and in vivo. C1 [Branco, Luis M.; Grove, Jessica N.; Garry, Robert F.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. [Branco, Luis M.] Autoimmune Technol LLC, New Orleans, LA USA. [Moses, Lina M.; Goba, Augustine; Bausch, Daniel G.] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA 70118 USA. [Schoepp, Randal J.] USA, Appl Diagnost Branch, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. [Goba, Augustine; Fullah, Mohammed; Momoh, Mambu] Kenema Govt Hosp, Lassa Fever Lab, Kenema, Sierra Leone. EM rfgarry@tulane.edu RI Valle, Ruben/A-7512-2013 FU Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases [AI067188, AI082119]; Louisiana Board of Regents [RC-0013-07]; Division of GEIS Operations at the Armed Forces Health Surveillance Center [C0169_10_RD] FX This work was supported by Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases Challenge and Partnership Grant Numbers AI067188 and AI082119, and RC-0013-07 from the Louisiana Board of Regents. The research described herein was sponsored in part by the Division of GEIS Operations at the Armed Forces Health Surveillance Center, Research Plan C0169_10_RD. We thank the members of the Hemorrhagic Fever Diagnostic Consortium, and Lassa Fever - Mano River Union for ongoing support. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 28 TC 6 Z9 6 U1 1 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD NOV 9 PY 2010 VL 7 AR 306 DI 10.1186/1743-422X-7-306 PG 11 WC Virology SC Virology GA 686QB UT WOS:000284709700001 PM 21062490 ER PT J AU Brown, BK Cox, J Gillis, A VanCott, TC Marovich, M Milazzo, M Antonille, TS Wieczorek, L McKee, KT Metcalfe, K Mallory, RM Birx, D Polonis, VR Robb, ML AF Brown, Bruce K. Cox, Josephine Gillis, Anita VanCott, Thomas C. Marovich, Mary Milazzo, Mark Antonille, Tanya Santelli Wieczorek, Lindsay McKee, Kelly T., Jr. Metcalfe, Karen Mallory, Raburn M. Birx, Deborah Polonis, Victoria R. Robb, Merlin L. TI Phase I Study of Safety and Immunogenicity of an Escherichia coli-Derived Recombinant Protective Antigen (rPA) Vaccine to Prevent Anthrax in Adults SO PLOS ONE LA English DT Article ID INHALATION ANTHRAX; MULTICENTER TRIAL; RHESUS MACAQUES; RESPONSES; TOLERANCE; CORRELATE; EFFICACY; IMMUNITY; RABBITS; TOXIN AB Background: The fatal disease caused by Bacillus anthracis is preventable with a prophylactic vaccine. The currently available anthrax vaccine requires a lengthy immunization schedule, and simpler and more immunogenic options for protection against anthrax are a priority for development. In this report we describe a phase I clinical trial testing the safety and immunogenicity of an anthrax vaccine using recombinant Escherichia coli-derived, B. anthracis protective antigen (rPA). Methodology/Principal Findings: A total of 73 healthy adults ages 18-40 were enrolled and 67 received 2 injections separated by 4 weeks of either buffered saline placebo, or rPA formulated with or without 704 mu g/ml Alhydrogel (R) adjuvant in increasing doses (5, 25, 50, 100 mu g) of rPA. Participants were followed for one year and safety and immunologic data were assessed. Tenderness and warmth were the most common post-injection site reactions. No serious adverse events related to the vaccine were observed. The most robust humoral immune responses were observed in subjects receiving 50 mu g of rPA formulated with Alhydrogel (R) with a geometric mean concentration of anti-rPA IgG antibodies of 283 mu g/ml and a toxin neutralizing geometric 50% reciprocal geometric mean titer of 1061. The highest lymphoproliferative peak cellular response (median Lymphocyte Stimulation Index of 29) was observed in the group receiving 25 mu g Alhydrogel (R)-formulated rPA. Conclusions/Significance: The vaccine was safe, well tolerated and stimulated a robust humoral and cellular response after two doses. C1 [Brown, Bruce K.; Cox, Josephine; Gillis, Anita; VanCott, Thomas C.; Milazzo, Mark; Antonille, Tanya Santelli; Wieczorek, Lindsay; Robb, Merlin L.] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. [Marovich, Mary; Birx, Deborah; Polonis, Victoria R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [McKee, Kelly T., Jr.; Metcalfe, Karen; Mallory, Raburn M.] DynPort Vaccine Co LLC, Frederick, MD USA. RP Brown, BK (reprint author), Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. EM mrobb@hivresearch.org FU Chemical Biological Medical Systems-Joint Vaccine Acquisition Program; DynPort Vaccine Company LLC FX Funding: This study was funded by the Chemical Biological Medical Systems-Joint Vaccine Acquisition Program (http://www.jpeocbd.osd.mil). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. DynPort Vaccine Company (DVC) supported Dr. McKee, Ms. Metcalfe, and Dr. Mallory, all of whom participated in the design of the study and review of the manuscript.; Competing Interests: Dr. Mallory was previously an employee of DynPort Vaccine Company LLC, a CSC company, and is currently employed by MedImmune LLC, a subsidiary of AstraZeneca. Dr. Kelly T. McKee Jr. was previously an employee of DynPort Vaccine Company LLC, a CSC company, and is currently employed by Quintiles Transnational Corporation. Dr. Josephine Cox was previously an employee of the US Military HIV Research Program and is currently employed by the International AIDS Vaccine Initiative. Dr. Thomas C. VanCott was previously an employee of the US Military HIV Research Program and is currently employed by Advanced BioScience Laboratories. Dr. Deborah Birx was previously an employee of the US Military HIV Research Program and is currently employed by the US Centers for Disease Control. DynPort Vaccine Company LLC was the study sponsor. None of the declared conflicting interests impede data sharing as described in the PLoS sharing guidelines. NR 24 TC 12 Z9 14 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 5 PY 2010 VL 5 IS 11 AR e13849 DI 10.1371/journal.pone.0013849 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 675OD UT WOS:000283839100008 PM 21079762 ER PT J AU Hernandez-Garcia, CM Bouchard, RA Rushton, PJ Jones, ML Chen, XF Timko, MP Finer, JJ AF Hernandez-Garcia, Carlos M. Bouchard, Robert A. Rushton, Paul J. Jones, Michelle L. Chen, Xianfeng Timko, Michael P. Finer, John J. TI High level transgenic expression of soybean (Glycine max) GmERF and Gmubi gene promoters isolated by a novel promoter analysis pipeline SO BMC PLANT BIOLOGY LA English DT Article ID GREEN FLUORESCENT PROTEIN; AGROBACTERIUM-MEDIATED TRANSFORMATION; ETHYLENE-RESPONSIVE ELEMENT; TRANSIENT GFP EXPRESSION; PARTICLE BOMBARDMENT; POLYUBIQUITIN PROMOTER; STABLE TRANSFORMATION; TRANSCRIPTION FACTORS; PLANT TRANSFORMATION; INTEGRATION PATTERNS AB Background: Although numerous factors can influence gene expression, promoters are perhaps the most important component of the regulatory control process. Promoter regions are often defined as a region upstream of the transcriptional start. They contain regulatory elements that interact with regulatory proteins to modulate gene expression. Most genes possess their own unique promoter and large numbers of promoters are therefore available for study. Unfortunately, relatively few promoters have been isolated and characterized; particularly from soybean (Glycine max). Results: In this research, a bioinformatics approach was first performed to identify members of the Gmubi (G.max ubiquitin) and the GmERF (G. max Ethylene Response Factor) gene families of soybean. Ten Gmubi and ten GmERF promoters from selected genes were cloned upstream of the gfp gene and successfully characterized using rapid validation tools developed for both transient and stable expression. Quantification of promoter strength using transient expression in lima bean (Phaseolus lunatus) cotyledonary tissue and stable expression in soybean hairy roots showed that the intensity of gfp gene expression was mostly conserved across the two expression systems. Seven of the ten Gmubi promoters yielded from 2- to 7-fold higher expression than a standard CaMV35S promoter while four of the ten GmERF promoters showed from 1.5- to 2.2-times higher GFP levels compared to the CaMV35S promoter. Quantification of GFP expression in stably-transformed hairy roots of soybean was variable among roots derived from different transformation events but consistent among secondary roots, derived from the same primary transformation events. Molecular analysis of hairy root events revealed a direct relationship between copy number and expression intensity; higher copy number events displayed higher GFP expression. Conclusion: In this study, we present expression intensity data on 20 novel soybean promoters from two different gene families, ubiquitin and ERF. We also demonstrate the utility of lima bean cotyledons and soybean hairy roots for rapid promoter analyses and provide novel insights towards the utilization of these expression systems. The soybean promoters characterized here will be useful for production of transgenic soybean plants for both basic research and commercial plant improvement. C1 [Hernandez-Garcia, Carlos M.; Bouchard, Robert A.; Jones, Michelle L.; Finer, John J.] Ohio State Univ, Dept Hort & Crop Sci, OARDC, Wooster, OH 44691 USA. [Rushton, Paul J.; Timko, Michael P.] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA. [Chen, Xianfeng] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA 22908 USA. [Rushton, Paul J.] S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA. [Chen, Xianfeng] Erdc, USACE, Environm Lab, Vicksburg, MS 39180 USA. RP Finer, JJ (reprint author), Ohio State Univ, Dept Hort & Crop Sci, OARDC, 1680 Madison Ave, Wooster, OH 44691 USA. EM finer.1@osu.edu RI Finer, John/N-4713-2014 OI Finer, John/0000-0001-8004-5468 FU United Soybean Board; CONACYT, Mexico FX We would like to thank Dr. Tea Meulia (MCIC/OARDC/OSU) for the technical assistance with confocal microscopy. We also thank Drs. Eric Stockinger and Leah McHale for the critical reading of this manuscript. Salaries and research support were provided by the United Soybean Board, and by State and Federal funds appropriated to The Ohio State University/Ohio Agricultural Research and Development Center. This research was partially supported by a fellowship from CONACYT, Mexico, to CMHG. Mention of trademark or proprietary products does not constitute a guarantee or warranty of the product by OSU/OARDC and also does not imply approval to the exclusion of other products that may also be suitable. Journal Article No HCS 10-09. NR 82 TC 28 Z9 29 U1 1 U2 28 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2229 J9 BMC PLANT BIOL JI BMC Plant Biol. PD NOV 4 PY 2010 VL 10 AR 237 DI 10.1186/1471-2229-10-237 PG 16 WC Plant Sciences SC Plant Sciences GA 685ED UT WOS:000284610500001 PM 21050446 ER PT J AU Gates, JD Clifton, GT Benavides, LC Sears, AK Carmichael, MG Hueman, MT Holmes, JP Jama, YH Mursal, M Zacharia, A Ciano, K Khoo, S Stojadinovic, A Ponniah, S Peoples, GE AF Gates, Jeremy D. Clifton, Guy T. Benavides, Linda C. Sears, Alan K. Carmichael, Mark G. Hueman, Matthew T. Holmes, Jarrod P. Jama, Yusuf H. Mursal, Mohamed Zacharia, Athina Ciano, Kathy Khoo, Steven Stojadinovic, Alexander Ponniah, Sathibalan Peoples, George E. TI Circulating regulatory T cells (CD4(+)CD25(+)FOXP3(+)) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide SO VACCINE LA English DT Article DE Vaccine; HER2/neu; Regulatory T cell ID TRANSCRIPTION FACTOR FOXP3; OVARIAN-CANCER; HER-2/NEU PROTOONCOGENE; IMMUNE-RESPONSE; CLINICAL-TRIAL; AUTOIMMUNE-DISEASES; INVARIANT CHAIN; DENDRITIC CELLS; TUMOR-IMMUNITY; E75 VACCINE AB Regulatory T cells (T-Reg), CD4(+)CD25(+)FOXP3(+), are implicated in suppressing tumor immune responses. We analyzed peripheral blood lymphocytes (PBL) from breast cancer patients receiving a modified HLA class II HER2/neu peptide (AE37) vaccine for T-Reg cells and correlated their levels with vaccine-specific immune responses. The mean CD4(+)CD25(+)FOXP3(+). T-Reg cells decreased in patients with vaccination with no significant difference in serum TGF-beta levels. IFN-gamma ELISPOT and DTH increased after vaccination with a good correlation between T-Reg cell reduction and size of DTH to AE37. The T-Reg cell reduction and associated immune response suggest that AE37 may be clinically useful. Published by Elsevier Ltd. C1 [Gates, Jeremy D.; Clifton, Guy T.; Benavides, Linda C.; Sears, Alan K.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Carmichael, Mark G.] Landstuhl Reg Med Ctr, Dept Hematol Oncol, Landstuhl, Germany. [Hueman, Matthew T.; Jama, Yusuf H.; Mursal, Mohamed; Zacharia, Athina; Ciano, Kathy; Khoo, Steven; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD 20814 USA. [Holmes, Jarrod P.] Naval Med Ctr San Diego, Dept Med, Div Hematol & Med Oncol, San Diego, CA USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Surg Oncol Serv, Washington, DC 20307 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil FU United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Department of Clinical Investigation at Walter Reed Army Medical Center; Antigen Express FX Supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation at Walter Reed Army Medical Center. The clinical trial was funded by Antigen Express. NR 59 TC 14 Z9 15 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 3 PY 2010 VL 28 IS 47 BP 7476 EP 7482 DI 10.1016/j.vaccine.2010.09.029 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 682XE UT WOS:000284435500006 PM 20858449 ER PT J AU Pirooznia, M Pozhitkov, A Perkins, EJ Deng, YP Brouwer, M AF Pirooznia, Mehdi Pozhitkov, Alexander Perkins, Edward J. Deng, Youping Brouwer, Marius TI Generation, analysis and functional annotation of expressed sequence tags from the sheepshead minnow (Cyprinodon variegatus) SO BMC GENOMICS LA English DT Article ID GENE ONTOLOGY; TOOL; DATABASE AB Background: Sheepshead minnow (Cyprinodon variegatus) are small fish capable of withstanding exposure to very low levels of dissolved oxygen, as well as extreme temperatures and salinities. It is an important model in understanding the impacts and biological response to hypoxia and co-occurring compounding stressors such as polycyclic aromatic hydrocarbons, endocrine disrupting chemicals, metals and herbicides. Here, we initiated a project to sequence and analyze over 10,000 ESTs generated from the Sheepshead minnow (Cyprinodon variegatus) as a resource for investigating stressor responses. Results: We sequenced 10,858 EST clones using a normalized cDNA library made from larval, embryonic and adult suppression subtractive hybridization-PCR (SSH) libraries. Post- sequencing processing led to 8,099 high quality sequences. Clustering analysis of these ESTs indentified 4,223 unique sequences containing 1,053 contigs and 3,170 singletons. BLASTX searches produced 1,394 significant (E-value < 10(-5)) hits and further Gene Ontology (GO) analysis annotated 388 of these genes. All the EST sequences were deposited by Expressed Sequence Tags database (dbEST) in GenBank (GenBank: GE329585 to GE337683). Gene discovery and annotations are presented and discussed. This set of ESTs represents a significant proportion of the Sheepshead minnow (Cyprinodon variegatus) transcriptome, and provides a material basis for the development of microarrays useful for further gene expression studies in association with stressors such as hypoxia, cadmium, chromium and pyrene. C1 [Deng, Youping] SpecPro Inc, Vicksburg, MS 39180 USA. [Pirooznia, Mehdi] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Pozhitkov, Alexander; Brouwer, Marius] Univ So Mississippi, Dept Coastal Sci, Hattiesburg, MS 39406 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Deng, YP (reprint author), SpecPro Inc, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Youping.Deng@usm.edu; Marius.Brouwer@usm.edu OI Pirooznia, Mehdi/0000-0002-4210-6458 FU US Army Environmental Quality; International Society of Intelligent Biological Medicine (ISIBM) FX This work was supported by the US Army Environmental Quality and Installations Basic Research Program and Toxicogenomics Focus Area. Publication of this supplement was made possible with support from the International Society of Intelligent Biological Medicine (ISIBM). NR 20 TC 1 Z9 1 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD NOV 2 PY 2010 VL 11 SU 2 AR S4 DI 10.1186/1471-2164-11-S2-S4 PG 7 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 745WA UT WOS:000289200100004 PM 21047385 ER PT J AU Brogan, J AF Brogan, Jesse TI EXPAND YOUR PARETO PRINCIPLE 80-20 metrics can evaluate viability of numerous endeavors SO INDUSTRIAL ENGINEER LA English DT Article C1 [Brogan, Jesse] Baltimore Chapter, Baltimore, MD USA. [Brogan, Jesse] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Brogan, J (reprint author), Baltimore Chapter, Baltimore, MD USA. NR 0 TC 2 Z9 2 U1 1 U2 3 PU INST INDUSTRIAL ENGINEERS PI NORCROSS PA 3577 PARKWAY LANE, STE 200, NORCROSS, GA 30092 USA SN 1542-894X J9 IND ENG JI Ind. Eng PD NOV PY 2010 VL 42 IS 11 BP 45 EP 49 PG 5 WC Engineering, Industrial SC Engineering GA 797UE UT WOS:000293154800019 ER PT J AU Katz, A Jameson, A AF Katz, Aaron Jameson, Antony TI Meshless Scheme Based on Alignment Constraints SO AIAA JOURNAL LA English DT Article; Proceedings Paper CT AIAA 19th Computational Fluid Dynamics Conference CY JUN 22-25, 2009 CL San Antonio, TX SP Amer Inst Aeronaut & Astronaut ID FINITE POINT METHOD; FLUID-FLOW; MECHANICS; TRANSPORT AB Development of a new meshless technique is described that presents certain advantages over conventional meshless schemes due to unique weights that force alignment of the derivative approximation. The method is completely meshless, yet retains the low storage and simple flux distribution technique that are characteristic of finite volume methods. The new method is based on the well-known Taylor series expansion method with least squares. The proposed weighting scheme significantly reduces storage and computational requirements compared to other meshless schemes. The scheme is shown to be analogous to finite volume schemes in many ways, but it still lacks a discrete telescoping property and is not discretely conservative. The method is applied to the Euler equations in two dimensions. Results are presented that agree well with established methods. C1 [Katz, Aaron; Jameson, Antony] Stanford Univ, Dept Aeronaut Astronaut, Stanford, CA 94305 USA. RP Katz, A (reprint author), USA, Aeroflightdynam Directorate, Washington, DC USA. RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 NR 31 TC 4 Z9 4 U1 1 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD NOV PY 2010 VL 48 IS 11 BP 2501 EP 2511 DI 10.2514/1.J050127 PG 11 WC Engineering, Aerospace SC Engineering GA 680RO UT WOS:000284252300005 ER PT J AU Freeman, RB Gartrell, CA Wakeley, LD Berney, ES Kelley, JR AF Freeman, Reed B. Gartrell, Chad A. Wakeley, Lillian D. Berney, Ernest S. Kelley, Julie R. TI Steel-shot method for measuring the density of soils SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Article DE soil density; soil moisture; in situ soil testing; soil properties AB The density of soil is crucial in engineering, construction, and research. Standard methods to determine density use procedures, equipment or expendable materials that limit their effectiveness in challenging field conditions. Some methods require burdensome logistics or have time requirements that limit their use or the number of tests that can be executed. A test method, similar to the sand-cone method, was developed that uses steel shot as the material to which a volume of soil is compared to calculate soil density. Steel shot is easily recovered and reused, eliminating the need for specialty sand and calibrated cones or containers, and allows rapid determination of the volume of displaced soil. Excavated soil also provides measurements of total mass and moisture content. Volume, mass, and moisture content are applied in simple calculations to determine wet and dry densities and unit weight of the soil. Proficiency in performing the test can be achieved with minimal training, and the required kit can be assembled for a reasonable cost. Field uses of the method in dry environments in a variety of soil types demonstrated that the method can produce repeatable results within 2% of the values of soil density determined by traditional methods, with advantages in logistics. C1 [Freeman, Reed B.; Gartrell, Chad A.; Wakeley, Lillian D.; Berney, Ernest S.; Kelley, Julie R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gartrell, CA (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM chad.a.gartrell@usace.army.mil NR 14 TC 1 Z9 1 U1 0 U2 4 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD NOV PY 2010 VL 47 IS 11 BP 1299 EP 1304 DI 10.1139/T10-034 PG 6 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 676NL UT WOS:000283919100010 ER PT J AU Saha, S Bambha, NK Bhattacharyya, SS AF Saha, Sankalita Bambha, Neal K. Bhattacharyya, Shuvra S. TI Design and implementation of embedded computer vision systems based on particle filters SO COMPUTER VISION AND IMAGE UNDERSTANDING LA English DT Article DE Design space exploration; Particle filters; Reconfigurable platforms AB Particle filtering methods are gradually attaining significant importance in a variety of embedded computer vision applications. For example, in smart camera systems, object tracking is a very important application and particle filter based tracking algorithms have shown promising results with robust tracking performance. However, most particle filters involve vast amount of computational complexity, thereby intensifying the challenges faced in their real-time, embedded implementation. Many of these applications share common characteristics, and the same system design can be reused by identifying and varying key system parameters and varying them appropriately. In this paper, we present a System-on-Chip (SoC) architecture involving both hardware and software components for a class of particle filters. The framework uses parameterization to enable fast and efficient reuse of the architecture with minimal re-design effort for a wide range of particle filtering applications as well as implementation platforms. Using this framework, we explore different design options for implementing three different particle filtering applications on field-programmable gate arrays (FPGAs). The first two applications involve particle filters with one-dimensional state transition models, and are used to demonstrate the key features of the framework The main focus of this paper is on design methodology for hardware/software implementation of multi-dimensional particle filter application and we explore this in the third application which is a 3D facial pose tracking system for videos. In this multi-dimensional particle filtering application, we extend our proposed architecture with models for hardware/software co-design so that limited hardware resources can be utilized most effectively. Our experiments demonstrate that the framework is easy and intuitive to use, while providing for efficient design and implementation. We present different memory management schemes along with results on trade-offs between area (FPGA resource requirement) and execution speed. (c) 2010 Elsevier Inc. All rights reserved. C1 [Saha, Sankalita] NASA, Ames Res Ctr, Mission Crit Technol Inc, Moffett Field, CA 94035 USA. [Bambha, Neal K.] USA, Res Lab, Adelphi, MD 20783 USA. [Bhattacharyya, Shuvra S.] Univ Maryland, Inst Adv Comp Studies, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Saha, S (reprint author), NASA, Ames Res Ctr, Mission Crit Technol Inc, Moffett Field, CA 94035 USA. EM sankalita.saha@nasa.gov; nbambha@arl.army.mil; ssb@umd.edu OI Bhattacharyya, Shuvra/0000-0001-7719-1106 NR 20 TC 7 Z9 7 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1077-3142 EI 1090-235X J9 COMPUT VIS IMAGE UND JI Comput. Vis. Image Underst. PD NOV PY 2010 VL 114 IS 11 BP 1203 EP 1214 DI 10.1016/j.cviu.2010.03.018 PG 12 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 675MN UT WOS:000283834900008 ER PT J AU Hromadka, TV Hromadka, TV Phillips, M AF Hromadka, T. V., II Hromadka, T. V., III Phillips, M. TI Use of Rainfall Statistical Return Periods to Determine Threshold for Mass Wasting Events SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE Mass Wasting; Rainfall; Return Period; Return Frequency; Infiltration; Earth Movement; Landslide; Debris Flow; Mudflow ID SHALLOW LANDSLIDES; 1994 NORTHRIDGE; CALIFORNIA; EARTHQUAKE AB Recent attention has been focused toward determination of threshold rainfall levels in the estimation and prediction of mass wasting events (such as landslides, mudflows, debris flows, sloughs, earth movements, and so forth). The literature indicates use of a cumulative rainfall value as a threshold that correlates mass wasting occurrence versus rainfall depth occurrence. In the current article, the threshold concept is extended to use of rainfall return period estimates. Return period estimates are developed for the peak 1-day, 2-day, and successively larger continuous peak durations of rainfall, to duration sizes of 1 year. Such a return period peak duration rainfall analysis is prepared for each rainfall season in the rain gauge record, resulting in a historic summary of peak duration return frequency based on every possible peak rainfall duration. By using return period as a measure of the rainfall depth for each peak duration, one can correlate the rareness of rainfall occurrence to the rareness of the mass wasting events for those events substantially triggered by rainfall. A similar type of analysis can be developed for estimates of infiltration by using a selected infiltration relationship and then synthesizing the resulting estimates in the same way that the rainfall data are analyzed. Once the entire history of the rain gauge is analyzed for infiltration, return period estimates can also be developed for use in possible correlation to mass wasting events. A case study involving a catastrophic landslide in La Conchita, California, is considered as an example application. C1 [Hromadka, T. V., II; Phillips, M.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Hromadka, T. V., III] Univ Calif San Diego, Dept Comp Sci, La Jolla, CA 92093 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. NR 19 TC 5 Z9 5 U1 1 U2 16 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD NOV PY 2010 VL 16 IS 4 BP 343 EP 356 PG 14 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 674EB UT WOS:000283715800002 ER PT J AU Becker, CR Currano, LJ Churaman, WA Stoldt, CR AF Becker, Collin R. Currano, Luke J. Churaman, Wayne A. Stoldt, Conrad R. TI Thermal Analysis of the Exothermic Reaction between Galvanic Porous Silicon and Sodium Perchlorate SO ACS APPLIED MATERIALS & INTERFACES LA English DT Letter DE porous silicon; nanoenergetics; calorimetry; MEMS ID DECOMPOSITION; DEHYDRATION; OXIDATION; EMISSION; POROSITY; KINETICS; FILMS AB Porous silicon (PS) films up to similar to 150 mu m thick with specific surface area similar to 700 m(2)/g and pore diameters similar to 3 nm are fabricated using a galvanic corrosion etching mechanism that does require a power supply. After fabrication the pores are impregnated with the strong oxidizer sodium perchlorate (NaClO4) to create a composite that constitutes a highly energetic system capable of explosion. Using bomb calorimetry, the heat of reaction is determined to be 9.9 +/- 1.8 and 27.3 +/- 3.2 kj/g of PS when ignited under N-2 and O-2 respectively. Differential scanning calorimetry (DSC) reveals that the energy output is dependent on the hydrogen termination of the PS. C1 [Becker, Collin R.; Stoldt, Conrad R.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. [Becker, Collin R.; Currano, Luke J.; Churaman, Wayne A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Stoldt, CR (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. EM conrad.stoldt@colorado.edu NR 26 TC 20 Z9 22 U1 0 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV PY 2010 VL 2 IS 11 BP 2998 EP 3003 DI 10.1021/am100975u PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 683EL UT WOS:000284454400009 PM 21058647 ER PT J AU Reddy, ALM Srivastava, A Gowda, SR Gullapalli, H Dubey, M Ajayan, PM AF Reddy, Arava Leela Mohana Srivastava, Anchal Gowda, Sanketh R. Gullapalli, Hemtej Dubey, Madan Ajayan, Pulickel M. TI Synthesis Of Nitrogen-Doped Graphene Films For Lithium Battery Application SO ACS NANO LA English DT Article DE nitrogen doped graphene; surface defects; chemical vapor deposition; Li battery; anode; cyclic performance ID MULTIWALLED CARBON NANOTUBES; MEMBRANE FUEL-CELLS; SUPERCAPACITOR ELECTRODES; INTERCALATION; PERFORMANCE; ANODE; INSERTION; STORAGE AB We demonstrate a controlled growth of nitrogen doped graphene layers by liquid precursor based chemical vapor deposition (CVD) technique Nitrogen doped graphene was grown directly on Cu current collectors and studied for its reversible Li ion intercalation properties Reversible discharge capacity of N dope graphene is almost double compared to pristine graphene due to the large number of surface defects induced due to N-doping All the graphene films were characterized by Raman spectroscopy, transmission electron microscopy, and X ray photoemission spectroscopy Direct growth of active electrode material on current collector substrates makes this a feasible and efficient process for integration into current battery manufacture technology C1 [Reddy, Arava Leela Mohana; Srivastava, Anchal; Gullapalli, Hemtej; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Gowda, Sanketh R.] Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77005 USA. [Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. RP Reddy, ALM (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RI Arava, Leela Mohana Reddy/J-3180-2015; Gullapalli, Hemtej/P-7247-2014 OI Gullapalli, Hemtej/0000-0003-1520-4287 FU Army Research Office FX We thank the Army Research Office for funding support NR 35 TC 708 Z9 720 U1 155 U2 1244 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD NOV PY 2010 VL 4 IS 11 BP 6337 EP 6342 DI 10.1021/nn101926g PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 682YD UT WOS:000284438000007 PM 20931996 ER PT J AU Hebert, CG Gupta, A Fernandes, R Tsao, CY Valdes, JJ Bentley, WE AF Hebert, Colin G. Gupta, Apoorv Fernandes, Rohan Tsao, Chen-Yu Valdes, James J. Bentley, William E. TI Biological Nanofactories Target and Activate Epithelial Cell Surfaces for Modulating Bacterial Quorum Sensing and Interspecies Signaling SO ACS NANO LA English DT Article DE quorum sensing; bacterial signaling; Escherichia coli; Caco 2; nanofactories; autoinducer 2 ID ESCHERICHIA-COLI; IN-VIVO; SALMONELLA-TYPHIMURIUM; VIBRIO-HARVEYI; DRUG-DELIVERY; PSEUDOMONAS-AERUGINOSA; AUTOINDUCER PRODUCTION; COMMUNICATION; EXPRESSION; VIRULENCE AB In order to control the behavior of bacteria present at the surface of human epithelial cells we have created a biological "nanofactory" construct that "coats" the epithelial cells and "activates" the surface to produce the bacterial quorum sensing signaling molecule autoinducer 2 (Al 2) Specifically, we demonstrate directed modulation of signaling among Eschrichia coli cells grown over the surface of human epithelial (Caco-2) cells through site-directed attachment of biological nanofactories These "factories" comprise a fusion protein expressed and purified from E coli containing two AI 2 bacterial synthases (Pfs and LuxS), a protein G IgG binding domain, and affinity ligands for purification The final factory is fabricated ex vivo by incubating with an anti CD26 antibody that binds the fusion protein and specifically targets the CD26 dipeptidyl peptidase found on the outer surface of Caco 2 cells This is the first report of the interntional "In vitro" synthesis of bacterial autoinducers at the surface of epithelial cells for the redirection of quorum sensing behaviors of bacteria We envision tools such as this will be useful for interrogating interpreting and disrupting signaling events associated with the microbiome localized in human intestine and other environments C1 [Hebert, Colin G.; Fernandes, Rohan; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. [Valdes, James J.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Gupta, Apoorv; Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Hebert, Colin G.; Fernandes, Rohan; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. FU Defense Threat Reduction Agency (DTRA); RW Deutsch Foundation; National Science Foundation FX The authors would like to thank A Beaven (Core Imaging Facility Cell Biology and Molecular Genetics University of Maryland) for her assistance with confocal imaging and T Dunn (Biomaterials Laboratory Fischell Department of Bioengineering University of Maryland) for his help in conducting the flow cytometry studies This work was also supported by the Defense Threat Reduction Agency (DTRA) the RW Deutsch Foundation and the National Science Foundation s EFRI program NR 54 TC 9 Z9 9 U1 1 U2 23 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD NOV PY 2010 VL 4 IS 11 BP 6923 EP 6931 DI 10.1021/nn1013066 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 682YD UT WOS:000284438000070 PM 21028779 ER PT J AU Wilson, DK White, MJ AF Wilson, D. Keith White, Michael J. TI Discrimination of Wind Noise and Sound Waves by Their Contrasting Spatial and Temporal Properties SO ACTA ACUSTICA UNITED WITH ACUSTICA LA English DT Article ID PARAMETER-ESTIMATION; BROAD-BAND; ARRAY; MICROPHONE; MECHANISMS; COHERENCE AB The spatial and temporal characteristics of outdoor wind noise are contrasted to those of unsteady acoustic signals through wavelet processing of data from a 49-microphone array. The results provide clear evidence that wind noise consists of non-planar, intermittent, and weakly coherent microgusts (small turbulent disturbances) propagating across the array. By applying beamforming algorithms to signal cross coherences calculated from complex continuous wavelet transforms (CWTs), the orientations of the microgusts and broadband acoustic signals can be deduced. Wavelet-based beamformers based on the conventional (Bartlett) steering method are shown to produce the most consistent results at low signal-to-noise ratios. A Gaussian-mixture-model classifier is formulated to distinguish between blasting sounds, unsteady but persistent sounds (music), and wind noise. Signal shape features reliably distinguish the blasting and music, whereas the relatively low coherence of the wind noise distinguishes it reliably from the acoustic signals. C1 [Wilson, D. Keith] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [White, Michael J.] USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Wilson, DK (reprint author), USA, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM D.Keith.Wilson@usace.army.mil; Michael.J.White@usace.army.mil RI White, Michael/B-3612-2009; Wilson, D. Keith/A-4687-2012 OI White, Michael/0000-0001-8450-9135; Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army (ASA-ALT) In-House; U.S. Army Research Laboratory; U.S. Army Armaments Research and Development Center - Acoustic Center for Excellence FX David Fisk, Douglas Punt, and Bonnie Jones (ERDC-CRREL), and Jeffery Mifflin (ERDC-CERL), played prominent roles in designing the microphone array and executing the experiment. The authors are extremely grateful for their expertise and dedication. We thank Roy Greenfield (Pennsylvania State University) for assistance in developing the data processing routines. This research was funded primarily by the U.S. Army (ASA-ALT) In-House, Laboratory Independent Research (ILIR) program. Additional funding was provided by the U.S. Army Research Laboratory and the U.S. Army Armaments Research and Development Center - Acoustic Center for Excellence. NR 23 TC 2 Z9 2 U1 0 U2 10 PU S HIRZEL VERLAG PI STUTTGART PA POSTFACH 10 10 61, D-70 009 STUTTGART, GERMANY SN 1610-1928 J9 ACTA ACUST UNITED AC JI Acta Acust. United Acust. PD NOV-DEC PY 2010 VL 96 IS 6 BP 991 EP 1002 DI 10.3813/AAA.918362 PG 12 WC Acoustics SC Acoustics GA 691LV UT WOS:000285082200001 ER PT J AU Wereszczak, AA Kirkland, TP Strong, KT Jadaan, OM Thompson, GA AF Wereszczak, A. A. Kirkland, T. P. Strong, K. T., Jr. Jadaan, O. M. Thompson, G. A. TI Size scaling of tensile failure stress in boron carbide SO ADVANCES IN APPLIED CERAMICS LA English DT Article DE Boron carbide; Weibull; Strength; Strength scaling ID BRITTLE MATERIALS; FRACTURE; COMPRESSION; DAMAGE; TILES AB Weibull strength size scaling in a rotary ground, hot pressed boron carbide is described when strength test coupons sampled effective areas from very small (similar to 0.001 mm(2)) to very large (similar to 40 000 mm(2)). The testing of this ceramic is relevant because it is a candidate material for use in personnel armour. Equibiaxial flexure and Hertzian testing were used for the strength testing. Characteristic strengths for several different specimen geometries are analysed as a function of effective area. Characteristic strength was found to substantially increase with decreased effective area and exhibited a bilinear relationship. Machining damage limited strength as measured with equibiaxial flexure testing for effective areas greater than similar to 1 mm(2), and microstructural scale flaws limited strength for effective areas, <0.1 mm(2) for the Hertzian testing. The selections of a ceramic strength to account for ballistically induced tile deflection and expanding cavity modelling are uniquely considered in context with the measured strength size scaling. C1 [Wereszczak, A. A.; Kirkland, T. P.; Strong, K. T., Jr.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Jadaan, O. M.] Univ Wisconsin, Coll Engn Math & Sci, Platteville, WI 53818 USA. [Thompson, G. A.] USA, DTRD, Great Lakes, IL USA. RP Wereszczak, AA (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. EM wereszczakaa@ornl.gov RI Wereszczak, Andrew/I-7310-2016 OI Wereszczak, Andrew/0000-0002-8344-092X FU US Army Tank-Automotive Research, Development, and Engineering Center [DE-AC05-00OR22725]; UT-Battelle, LLC FX This research was sponsored by the Work for Others sponsor US Army Tank-Automotive Research, Development, and Engineering Center under contract no. DE-AC05-00OR22725 with UT-Battelle, LLC. H.-T. Lin (ORNL, Oak Ridge, TN, USA) is thanked for assisting with the scanning electron microscopy, and K. Johanns (University of Tennessee, Knoxville, TN, USA) is thanked for assistance with the effective area estimations. Lastly, the authors thank J. Hemrick and A. Shyam (ORNL) for reviewing the manuscript and for their helpful comments. NR 17 TC 1 Z9 1 U1 1 U2 9 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 1743-6753 J9 ADV APPL CERAM JI Adv. Appl. Ceram. PD NOV PY 2010 VL 109 IS 8 BP 487 EP 492 DI 10.1179/174367510X12677121374546 PG 6 WC Materials Science, Ceramics SC Materials Science GA 690KA UT WOS:000285002300005 ER PT J AU Vanfosson, CA AF Vanfosson, Christopher A. TI Preparing for a Year on the Battlefield SO AMERICAN JOURNAL OF NURSING LA English DT Editorial Material C1 [Vanfosson, Christopher A.] USA, Nurse Corps, Ft Bragg, NC USA. RP Vanfosson, CA (reprint author), USA, Nurse Corps, Ft Bragg, NC USA. EM christopher.vanfosson@mail.us.army.mil OI VanFosson, Christopher/0000-0003-1640-3018 NR 0 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD NOV PY 2010 VL 110 IS 11 BP 52 EP 54 DI 10.1097/01.NAJ.0000390524.06690.71 PG 3 WC Nursing SC Nursing GA 672KE UT WOS:000283581000021 PM 20980900 ER PT J AU Mu, XD Urso, ML Murray, K Fu, F Li, Y AF Mu, Xiaodong Urso, Maria L. Murray, Kiley Fu, Freddie Li, Yong TI Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID REVERSES CARDIAC FIBROSIS; ENDOTHELIAL GROWTH-FACTOR; SKELETAL-MUSCLE; IN-VIVO; MATRIX METALLOPROTEINASES; STEM-CELLS; TRANSPLANTED MYOBLASTS; LIVER FIBROSIS; MDX MICE; T-CELLS AB The polypeptide hormone relaxin has been proven to be effective in promoting both the remodeling and regeneration of various tissues, including cardiac muscle. In addition, our previous study demonstrated that relaxin is beneficial to skeletal muscle healing by both promoting muscle regeneration and preventing fibrosis formation. However, the molecular and cellular mechanisms of relaxin in regulating both myogenic cell differentiation and muscle healing process are still unclear. In this study, C2C12 mouse myoblasts and primary human myoblasts were treated with relaxin to investigate its potential effect in vitro; relaxin was also injected intramuscularly into the injured site of the mouse on the second day after injury to observe its function in vivo, especially in the aged muscle. Results showed that relaxin promoted myogenic differentiation, migration, and activation of matrix metalloproteinases (MMPs) of cultured myoblasts in vitro. In the injured muscle, relaxin administration promoted the activation of Pax7-positive skeletal muscle satellite cells and increased its local population compared with non-treated control muscles. Meanwhile, both angiogenesis and revascularization were increased, while the extended inflammatory reaction was repressed in the relaxin-treated injured muscle. Moreover, relaxin similarly promoted muscle healing in mice with aged muscle. These results revealed the multiple effects of relaxin in systematically improving muscle healing as well as its potential for clinical applications in patients with skeletal muscle injuries and diseases. (Am J Pathol 2010, 177:2399-2410; DOI: 10.2353/ajpath.2010.091121) C1 [Li, Yong] Univ Pittsburgh, Med Ctr, Childrens Hosp Pittsburgh, SCRC,Lab Mol Pathol,Off 217, Pittsburgh, PA 15219 USA. [Mu, Xiaodong; Fu, Freddie; Li, Yong] Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA USA. [Li, Yong] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA. [Urso, Maria L.] USA, Mil Performance Div, Inst Environm Med USARIEM, Natick, MA 01760 USA. RP Li, Y (reprint author), Univ Pittsburgh, Med Ctr, Childrens Hosp Pittsburgh, SCRC,Lab Mol Pathol,Off 217, Bridgeside Point 2,450 Technol Dr, Pittsburgh, PA 15219 USA. EM yongli@pitt.edu RI Li, Yong/B-3628-2011; Mu, Xiaodong/A-2474-2012; OI Urso, Maria/0000-0001-8906-4673 FU National Institutes of Health; Department of Defense; NFL Charities, Medical FX Supported by an NFL Charities, Medical grant made in 2008, and in part by National Institutes of Health and Department of Defense grants (Y.L.). NR 84 TC 25 Z9 27 U1 0 U2 6 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD NOV PY 2010 VL 177 IS 5 BP 2399 EP 2410 DI 10.2353/ajpath.2010.091121 PG 12 WC Pathology SC Pathology GA 679TE UT WOS:000284182900027 PM 20934971 ER PT J AU Bakhshi, T Landon, MB Lai, YL Spong, CY Rouse, DJ Leveno, KJ Varner, MW Caritis, SN Meis, PJ Wapner, RJ Sorokin, Y Miodovnik, M Carpenter, M Peaceman, AM O'Sullivan, MJ Sibai, BM Langer, O Thorp, JM Mercer, BM AF Bakhshi, Tiki Landon, Mark B. Lai, Yinglei Spong, Catherine Y. Rouse, Dwight J. Leveno, Kenneth J. Varner, Michael W. Caritis, Steve N. Meis, Paul J. Wapner, Ronald J. Sorokin, Yoram Miodovnik, Menachem Carpenter, Marshall Peaceman, Alan M. O'Sullivan, Mary J. Sibai, Baha M. Langer, Oded Thorp, John M. Mercer, Brian M. TI Maternal and Neonatal Outcomes of Repeat Cesarean Delivery in Women with a Prior Classical versus Low Transverse Uterine Incision SO AMERICAN JOURNAL OF PERINATOLOGY LA English DT Article; Proceedings Paper CT 28th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 28-FEB 02, 2008 CL Dallas, TX SP Soc Maternal Fetal Med DE Cesarean delivery; classical cesarean delivery; prior cesarean; maternal outcomes; neonatal outcomes ID SECTION AB We compared maternal and neonatal outcomes following repeat cesarean delivery (CD) of women with a prior classical CD with those with a prior low transverse CD. The Maternal Fetal Medicine Units Network Cesarean Delivery Registry was used to identify women with one previous CD who underwent an elective repeat CD prior to the onset of labor at >= 36 weeks. Outcomes were compared between women with a previous classical CD and those with a prior low transverse CD. Of the 7936 women who met study criteria, 122 had a prior classical CD. Women with a prior classical CD had a higher rate of classical uterine incision at repeat CD (12.73% versus 0.59%; p<0.001), had longer total operative time and hospital stay, and had higher intensive care unit admission. Uterine dehiscence was more frequent in women with a prior classical CD (2.46% versus 0.27%, odds ratio 9.35, 95% confidence interval 1.76 to 31.93). After adjusting for confounding factors, there were no statistical differences in major maternal or neonatal morbidities between groups. Uterine dehiscence was present at repeat CD in 2.46% of women with a prior classical CD. However, major maternal morbidities were similar to those with a prior low transverse CD. C1 [Bakhshi, Tiki] Univ Texas Hlth Sci Ctr Houston, Dept Obstet, Houston, TX USA. [Bakhshi, Tiki] Univ Texas Hlth Sci Ctr Houston, Dept Gynecol, Houston, TX USA. [Landon, Mark B.] Ohio State Univ, Columbus, OH 43210 USA. [Rouse, Dwight J.] Univ Alabama, Birmingham, AL USA. [Leveno, Kenneth J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Varner, Michael W.] Univ Utah, Salt Lake City, UT USA. [Caritis, Steve N.] Univ Pittsburgh, Pittsburgh, PA USA. [Meis, Paul J.] Wake Forest Univ Hlth Sci, Winston Salem, NC USA. [Wapner, Ronald J.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Sorokin, Yoram] Wayne State Univ, Detroit, MI USA. [Miodovnik, Menachem] Univ Cincinnati, Cincinnati, OH USA. [Miodovnik, Menachem] Columbia Univ, New York, NY USA. [Carpenter, Marshall] Brown Univ, Providence, RI 02912 USA. [Peaceman, Alan M.] Northwestern Univ, Chicago, IL 60611 USA. [O'Sullivan, Mary J.] Univ Miami, Miami, FL USA. [Sibai, Baha M.] Univ Tennessee, Memphis, TN USA. [Langer, Oded] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. [Thorp, John M.] Univ N Carolina, Chapel Hill, NC USA. [Mercer, Brian M.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Lai, Yinglei] George Washington Univ, Ctr Biostat, Washington, DC USA. [Spong, Catherine Y.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. RP Bakhshi, T (reprint author), Tripler Army Med Ctr, Dept OB GYN, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM tiki.bakh-shi@amedd.army.mil RI Varner, Michael/K-9890-2013 OI caritis, steve/0000-0002-2169-0712; Peaceman, Alan/0000-0002-4515-4850; Varner, Michael/0000-0001-9455-3973 FU NCATS NIH HHS [UL1 TR000005]; NICHD NIH HHS [U10 HD040485, U10 HD034208-12, U10 HD040500-08, HD27915, U10 HD027861-10S2, UG1 HD040500, U10 HD021414-15S2, U10 HD027860, U10 HD027869-10, UG1 HD027915, HD40545, U10 HD021410, HD36801, R24 HD050924, U10 HD027917-18, HD27869, UG1 HD034116, HD34210, U01 HD036801, HD40512, U10 HD034122-05, HD21414, U10 HD040544-10, U10 HD040500, U10 HD027915, U10 HD034116, UG1 HD034208, HD40500, HD40560, HD27860, HD34116, UG1 HD040545, U10 HD034122, U10 HD034210-05, UG1 HD040544, U10 HD034116-13, U10 HD034208, UG1 HD040485, U10 HD040545, U10 HD040512, U10 HD040512-10, U10 HD036801, U10 HD027860-15, U10 HD027905, U10 HD034136, HD40544, U10 HD027917, U10 HD040485-10, U10 HD040560, U10 HD040545-10, U10 HD040560-10, HD27861, U10 HD040544, U10 HD027915-19, HD27917, U10 HD021410-22, U01 HD036801-10, UG1 HD040560, HD34136, U10 HD027869, U10 HD034136-10S2, UG1 HD027869, U10 HD027905-10, HD40485, UG1 HD040512, HD21410, HD34208] NR 7 TC 12 Z9 12 U1 0 U2 4 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0735-1631 J9 AM J PERINAT JI Am. J. Perinatol. PD NOV PY 2010 VL 27 IS 10 BP 791 EP 795 DI 10.1055/s-0030-1254238 PG 5 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 664GJ UT WOS:000282948100006 PM 20458666 ER PT J AU Moawad, FJ Maydonovitch, CL Cullen, PA Barlow, DS Jenson, DW Cash, BD AF Moawad, Fouad J. Maydonovitch, Corinne L. Cullen, Priscilla A. Barlow, Duncan S. Jenson, Donald W. Cash, Brooks D. TI CT Colonography May Improve Colorectal Cancer Screening Compliance SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE colonoscopy; CT colonography; patient preferences; screening ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; CMSS LANDMARK DECISION; SERVICES TASK-FORCE; CONVENTIONAL COLONOSCOPY; EXTRACOLONIC FINDINGS; VIRTUAL COLONOSCOPY; COLONIC PERFORATION; ASYMPTOMATIC ADULTS; AMERICAN-COLLEGE; RISK AB OBJECTIVE. While colonoscopy is currently the preferred test for colorectal cancer (CRC) screening, the invasive and time-consuming characteristics of the test are often cited as reasons for noncompliance with screening. CT colonography (CTC) is a less invasive screening method that is comparable to colonoscopy for the detection of advanced neoplasia. The aim of this project was to assess patient preferences between colonoscopy and CTC in an open access system. MATERIALS AND METHODS. Two hundred fifty consecutive average-risk patients undergoing CRC screening completed a survey that assessed reasons for choosing CTC in lieu of colonoscopy, compliance with CRC screening if CTC was not offered, and which of the two tests they preferred. RESULTS. The most common reasons for undergoing CTC included convenience (33.6%), recommendation by referring provider (13.2%), and perceived safety (10.8%). Had CTC not been an available option, 91 of the 250 patients (36%) would have foregone CRC screening. Among the 57 patients who had experienced both procedures, 95% (n = 54) preferred CTC. CONCLUSION. These findings show the importance of providing CTC as an alternative screening option for CRC at our institution, which may increase CRC adherence screening rates. C1 [Moawad, Fouad J.; Maydonovitch, Corinne L.] Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, Bethesda, MD 20889 USA. [Cullen, Priscilla A.; Barlow, Duncan S.; Jenson, Donald W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Cash, Brooks D.] Natl Naval Med Ctr, Dept Radiol, Bethesda, MD USA. [Cash, Brooks D.] Natl Naval Med Ctr, Div Gastroenterol, Bethesda, MD USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Fouad.Moawad@amedd.army.mil NR 49 TC 37 Z9 37 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2010 VL 195 IS 5 BP 1118 EP 1123 DI 10.2214/AJR.10.4921 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 668TY UT WOS:000283295300024 PM 20966316 ER PT J AU Houghton, R Ben Salah, A Nabil, BHH Zaatour, A Gharbi, A Chen, J Morkowski, S Moon, J Stevens, Y Raychaudhuri, S Grogl, M Kreishman-Deitrick, M Jasper, L Magill, AJ AF Houghton, Raymond Ben Salah, Afif Nabil, Bel Haj Hamida Zaatour, Amor Gharbi, Adel Chen, Jean Morkowski, Stan Moon, Jennifer Stevens, Yvonne Raychaudhuri, Syamal Grogl, Max Kreishman-Deitrick, Mara Jasper, Louis Magill, Alan J. TI A SIMPLE HAND-HELD TEST FOR RAPID DIAGNOSIS OF CUTANEOUS LEISHMANIASIS IN THE FIELD: OPTIMIZATION OF SAMPLE COLLECTION METHODS FROM LESIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Houghton, Raymond; Chen, Jean; Morkowski, Stan; Moon, Jennifer; Stevens, Yvonne; Raychaudhuri, Syamal] InBios Int Inc, Seattle, WA USA. [Ben Salah, Afif; Nabil, Bel Haj Hamida; Zaatour, Amor; Gharbi, Adel] Inst Pasteur Tunis, Tunis, Tunisia. [Grogl, Max; Magill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kreishman-Deitrick, Mara] US Army Med Mat Dev Activ, Ft Detrick, MD USA. [Jasper, Louis] US Army Med Mat Dev Activ, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 49 BP 15 EP 16 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700050 ER PT J AU Caci, JB Lyons, A Tack, DM AF Caci, Jennifer B. Lyons, Arthur Tack, Danielle M. TI SEROPREVALENCE OF DENGUE FEVER IN US ARMY SPECIAL OPERATIONS FORCES - INITIAL RESULTS AND THE WAY FORWARD SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Caci, Jennifer B.] USA, Special Operat Command, Ft Bragg, NC USA. [Lyons, Arthur] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tack, Danielle M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 90 BP 28 EP 28 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700091 ER PT J AU Klungthong, C Nisalak, A Thaisomboonsuk, B Latthiwongsakorn, N Poolpanichupatam, Y Hunsawong, T Gibbons, RV Jarman, RG AF Klungthong, Chonticha Nisalak, Ananda Thaisomboonsuk, Butsaya Latthiwongsakorn, Napaporn Poolpanichupatam, Yongyuth Hunsawong, Taweewun Gibbons, Robert V. Jarman, Richard G. TI DENGUE VIRUS CROSS-PROTECTIVE IMMUNITY IN SHAPING HETEROGENEOUS SEROTYPE EPIDEMIC CIRCULATION PATTERNS, A STUDY OF DENGUE VIRUS TYPE 1 AND 4 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Klungthong, Chonticha; Nisalak, Ananda; Thaisomboonsuk, Butsaya; Latthiwongsakorn, Napaporn; Poolpanichupatam, Yongyuth; Hunsawong, Taweewun; Gibbons, Robert V.; Jarman, Richard G.] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 95 BP 29 EP 29 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700096 ER PT J AU Awandare, GA Jiang, LB Moch, JK Ockenhouse, CF Haynes, JD Miller, LH Stoute, JA AF Awandare, Gordon A. Jiang, Lubin Moch, J. Kathleen Ockenhouse, Christian F. Haynes, J. David Miller, Louis H. Stoute, Jose A. TI MALARIA PARASITE PLASMODIUM FALCIPARUM DD2 SPONTANEOUSLY SWITCHES FROM SIALIC ACID-DEPENDENT TO SIALIC-ACID INDEPENDENT ERYTHROCYTE INVASION IN SUSPENSION CULTURE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Awandare, Gordon A.; Moch, J. Kathleen; Ockenhouse, Christian F.; Haynes, J. David] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Jiang, Lubin; Miller, Louis H.] NIAID, Malaria Cell Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Stoute, Jose A.] Penn State Univ, Coll Med, Div Infect Dis, Dept Med, Hershey, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 128 BP 39 EP 39 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700129 ER PT J AU Bantuchai, S AF Bantuchai, Sirasate TI EVALUATION OF REVERSE-TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (RT-LAMP) FOR PLASMODIUM FALCIPARUM GAMETOCYTE DETECTION IN ENDEMIC AREA OF THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Bantuchai, Sirasate] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 135 BP 40 EP 41 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700136 ER PT J AU Sheehy, SH Duncan, CJ Elias, S Collins, K Ewer, K Edwards, N Blagborough, A Sinden, R Murphy, J Correa, S Hunt-Cooke, A Meyer, J Lillie, P Colloca, S Cortese, R Nicosia, A Poulton, I Long, CA Gilbert, SC Lawrie, A Hill, AV Draper, SJ AF Sheehy, Susanne H. Duncan, Christopher J. Elias, Sean Collins, Katharine Ewer, Katie Edwards, Nick Blagborough, Andrew Sinden, Robert Murphy, Jitta Correa, Simon Hunt-Cooke, Angela Meyer, Joel Lillie, Patrick Colloca, Stefano Cortese, Riccardo Nicosia, Alfredo Poulton, Ian Long, Carole A. Gilbert, Sarah C. Lawrie, Alison Hill, Adrian V. Draper, Simon J. TI HETEROLOGOUS PRIME-BOOST VACCINATION WITH ADCH63 AND MVA EXPRESSING MSP1 CAN INDUCE PROTECTIVE EFFICACY AGAINST SPOROZOITE CHALLENGE IN VOLUNTEERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Sheehy, Susanne H.; Duncan, Christopher J.; Hunt-Cooke, Angela; Meyer, Joel; Lillie, Patrick; Poulton, Ian; Lawrie, Alison] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England. [Elias, Sean; Collins, Katharine; Ewer, Katie; Edwards, Nick; Gilbert, Sarah C.; Hill, Adrian V.; Draper, Simon J.] Univ Oxford, Jenner Inst, Oxford, England. [Blagborough, Andrew; Sinden, Robert] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England. [Murphy, Jitta] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, MD 20307 USA. [Correa, Simon] MRC Labs, Banjul, Gambia. [Colloca, Stefano; Cortese, Riccardo; Nicosia, Alfredo] Okairos SRL, Rome, Italy. [Long, Carole A.] NIAID, NIH, Rockville, MD USA. RI Duncan, Christopher/A-2018-2012 OI Duncan, Christopher/0000-0003-4181-2315 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 160 BP 48 EP 49 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700161 ER PT J AU Thera, MA Coulibaly, D Laurens, MB Kone, AK Guindo, AB Diallo, D Traore, K Dolo, A Tolo, Y Sissoko, MS Kouriba, B Lyke, KE Takala-Harrison, S Blackwelder, WC Vekemans, J Cohen, J Dube, T Lanar, DE Dutta, S House, B Diggs, CL Soisson, L Heppner, DG Doumbo, OK Plowe, CV Traore, I Diarra, I Niangaly, A Daou, M Sissoko, M Wu, YK Godeaux, O Dubois, MC Ballou, R Thompson, D Bennett, JW AF Thera, Mahamadou A. Coulibaly, Drissa Laurens, Matthew B. Kone, Abdoulaye K. Guindo, Ando B. Diallo, Dapa Traore, Karim Dolo, Amagana Tolo, Youssouf Sissoko, Mahamadou S. Kouriba, Bourema Lyke, Kirsten E. Takala-Harrison, Shannon Blackwelder, William C. Vekemans, Johan Cohen, Joe Dube, Tina Lanar, David E. Dutta, Sheetij House, Brent Diggs, Carter L. Soisson, Lorraine Heppner, D. Gray Doumbo, Ogobara K. Plowe, Christopher V. Traore, Idrissa Diarra, Issa Niangaly, Amadou Daou, Modibo Sissoko, Mady Wu, Yukun Godeaux, Olivier Dubois, Marie-Claude Ballou, Ripley Thompson, Darby Bennett, Jason W. TI EXTENDED SAFETY, IMMUNOGENICITY AND EFFICACY OF WALTER REED ARMY INSTITUTE OF RESEARCH'S AMA-1 MALARIA VACCINE (FMP2.1) ADJUVANTED IN GSK BIOLOGICALS' AS02A IN 1-6 YEAR OLD CHILDREN IN BANDIAGARA, MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Thera, Mahamadou A.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Diallo, Dapa; Traore, Karim; Dolo, Amagana; Tolo, Youssouf; Sissoko, Mahamadou S.; Kouriba, Bourema; Doumbo, Ogobara K.] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. [Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Vekemans, Johan; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Dube, Tina] EMMES Corp, Rockville, MD USA. [Lanar, David E.; Dutta, Sheetij; House, Brent; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Diggs, Carter L.; Soisson, Lorraine] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 161 BP 49 EP 49 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700162 ER PT J AU Orshan, L Zollner, G AF Orshan, Laor Zollner, Gabriela TI BASIC EFFICACY OF ORAL INSECTICIDES IN TOXIC SUGAR BAITS TO CONTROL SAND FLIES AND MOSQUITOES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Orshan, Laor] Minist Hlth, Entomol Lab, Jerusalem, Israel. [Zollner, Gabriela] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 175 BP 53 EP 53 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700176 ER PT J AU Ponlawat, A Kankaew, P Chanaimongkol, S Evans, B Richardson, J AF Ponlawat, Alongkot Kankaew, Prasan Chanaimongkol, Somporn Evans, Brian Richardson, Jason TI A SEMI-FIELD, TUNNEL ASSAY FOR THE EVALUATION OF SPATIAL REPELLENTS IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Ponlawat, Alongkot; Kankaew, Prasan; Chanaimongkol, Somporn; Evans, Brian; Richardson, Jason] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 191 BP 57 EP 57 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700192 ER PT J AU Kankaew, P Leemingsawat, S Apiwathnasorn, C Thongrungkiat, S Ponlawat, A AF Kankaew, Prasan Leemingsawat, Somjai Apiwathnasorn, Chamnarn Thongrungkiat, Supatra Ponlawat, Alongkot TI DISTRIBUTION AND IDENTIFICATION OF ANOPHELES BARBIROSTRIS/CAMPESTRIS AT SA KAEO PROVINCE IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kankaew, Prasan; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Leemingsawat, Somjai; Apiwathnasorn, Chamnarn; Thongrungkiat, Supatra] Mahidol Univ, Fac Trop Med, Dept Med Entomol, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 203 BP 61 EP 61 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700204 ER PT J AU Korkusol, A Takhampunya, R Monkanna, T Khlaimanee, N Evans, B Richardson, J AF Korkusol, Achareeya Takhampunya, Ratree Monkanna, Taweesak Khlaimanee, Nittaya Evans, Brian Richardson, Jason TI DEVELOPMENT OF A MOLECULAR TAXONOMIC KEY FOR THE IDENTIFICATION OF SCRUB TYPHUS VECTORS, MITES WITHIN THE GENUS LEPTOTROMBIDIUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Korkusol, Achareeya; Takhampunya, Ratree; Monkanna, Taweesak; Khlaimanee, Nittaya; Evans, Brian; Richardson, Jason] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 202 BP 61 EP 61 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700203 ER PT J AU Zollner, G Orshan, L AF Zollner, Gabriela Orshan, Laor TI EVALUATION OF A METOFLUTHRIN FAN VAPORIZER DEVICE AGAINST PHLEBOTOMINE SAND FLIES (DIPTERA: PSYCHODIDAE) IN A CUTANEOUS LEISHMANISIS FOCUS IN THE JUDEAN DESERT, ISRAEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Zollner, Gabriela] Walter Reed Army Inst Res, Silver Spring, MD USA. [Orshan, Laor] Minist Hlth, Entomol Lab, Jerusalem, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 206 BP 62 EP 62 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700207 ER PT J AU Reyes, S Zhang, J Zeng, Q Harris, E Zhang, P Xie, LS Sousa, J McCalmont, W Kozar, M Li, QG AF Reyes, Sean Zhang, Jing Zeng, Qiang Harris, Erin Zhang, Ping Xie, Lisa Sousa, Jason McCalmont, William Kozar, Michael Li, Qigui TI IMPROVING RELATIVE BIOAVAILABILITY AND PROPHYLACTIC EFFICACY OF ORAL WR299958 BY REDUCING PARTICLE SIZE USING AN ULTRA-SONICATOR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Reyes, Sean; Zhang, Jing; Zeng, Qiang; Harris, Erin; Zhang, Ping; Xie, Lisa; Sousa, Jason; McCalmont, William; Kozar, Michael; Li, Qigui] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 245 BP 73 EP 73 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700246 ER PT J AU Lanteri, CA Ohrt, C Gettayacamin, M Melendez, V Pybus, B Sousa, J Tungtaeng, A White, K Walker, L Charman, SA AF Lanteri, Charlotte A. Ohrt, Colin Gettayacamin, Montip Melendez, Victor Pybus, Brandon Sousa, Jason Tungtaeng, Anchalee White, Karen Walker, Larry Charman, Susan A. TI THE ANTIMALARIAL EFFICACY OF PRIMAQUINE: THE ROLE OF CYTOCHROME P450-MEDIATED METABOLITES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Lanteri, Charlotte A.; Ohrt, Colin; Melendez, Victor; Pybus, Brandon; Sousa, Jason] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [White, Karen; Charman, Susan A.] Monash Inst Pharmaceut Sci, Parkville, Vic, Australia. [Walker, Larry] Univ Mississippi, University, MS 38677 USA. RI Charman, Susan/E-2221-2011 OI Charman, Susan/0000-0003-1753-8213 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 248 BP 74 EP 74 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700249 ER PT J AU Pybus, BS Poore, DD Sousa, J Carroll, D Kozar, MP Melendez, V AF Pybus, Brandon S. Poore, Duke D. Sousa, Jason Carroll, Dustin Kozar, Michael P. Melendez, Victor TI AN LC-MS BASED METHOD FOR THE MICRO-SAMPLING AND MEASUREMENT OF COMMON ANTIMALARIAL DRUGS IN VIVO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Pybus, Brandon S.; Poore, Duke D.; Sousa, Jason; Carroll, Dustin; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 251 BP 75 EP 75 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700252 ER PT J AU Sousa, J Carroll, D Milner, E Caridha, D Gardner, S Lanteri, C Li, QQ McCalmont, W Moon, J Obaldi, N Tangteung, A Roncal, N Smith, B Zeng, Q Kozar, MP Dow, G AF Sousa, Jason Carroll, Dustin Milner, Erin Caridha, Diana Gardner, Sean Lanteri, Charlotte Li, Quiqui McCalmont, William Moon, Jay Obaldi, Nicanor Tangteung, Anchalee Roncal, Norma Smith, Bryan Zeng, Qiang Kozar, Michael P. Dow, Geoffrey TI THE USE OF A PRODRUG APPROACH TO MINIMIZE POTENTIAL CNS EXPOSURE OF NEXT GENERATION QUINOLINE METHANOLS WHILE MAINTAINING EFFICACY IN IN VIVO ANIMAL MODELS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Sousa, Jason; Carroll, Dustin; Milner, Erin; Caridha, Diana; Gardner, Sean; Lanteri, Charlotte; Li, Quiqui; McCalmont, William; Moon, Jay; Obaldi, Nicanor; Tangteung, Anchalee; Roncal, Norma; Smith, Bryan; Zeng, Qiang; Kozar, Michael P.; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 252 BP 75 EP 75 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700253 ER PT J AU Carroll, D Pybus, BS Sousa, J Olmeda, R Li, QQ Lin, AJ Kozar, MP Melendez, V AF Carroll, Dustin Pybus, Brandon S. Sousa, Jason Olmeda, Raul Li, Quiqui Lin, Ai J. Kozar, Michael P. Melendez, Victor TI IN VITRO AND IN VIVO METABOLIC AND PHARMACOKINETIC PROFILES OF WR283194, A NOVEL ANTIMALARIAL DRUG CANDIDATE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Carroll, Dustin; Pybus, Brandon S.; Sousa, Jason; Olmeda, Raul; Li, Quiqui; Lin, Ai J.; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 253 BP 76 EP 76 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700254 ER PT J AU Jin, XN Collazo, V Luong, TL Reese, N Pybus, BS Sousa, J Carroll, D Asher, C Olmeda, R Kozar, MP Melendez, V AF Jin, Xiannu Collazo, Vanessa Thu Lan Luong Reese, NeCole Pybus, Brandon S. Sousa, Jason Carroll, Dustin Asher, Constance Olmeda, Raul Kozar, Michael P. Melendez, Victor TI PERMEABILITY OF ANTIMALARIAL DRUG CANDIDATES USING CACO-2 AND MDCK CELL LINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Jin, Xiannu; Collazo, Vanessa; Thu Lan Luong; Reese, NeCole; Pybus, Brandon S.; Sousa, Jason; Carroll, Dustin; Asher, Constance; Olmeda, Raul; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 255 BP 76 EP 76 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700256 ER PT J AU Luong, TL Lin, AJ Sousa, J Liu, XJ Li, QQ Olmeda, R Xie, LS Zhang, J Kozar, MP Melendez, V AF Thu Lan Luong Lin, Ai J. Sousa, Jason Liu, Xianjun Li, Qiqui Olmeda, Raul Xie, Lisa Zhang, Jing Kozar, Michael P. Melendez, Victor TI IN VITRO AND IN VIVO METABOLIC PROFILE OF TWO DEOXO-IMIDAZOLIDINEDIONE ANALOGS WITH ANTIMALARIAL PROPERTIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Thu Lan Luong; Lin, Ai J.; Sousa, Jason; Liu, Xianjun; Li, Qiqui; Olmeda, Raul; Xie, Lisa; Zhang, Jing; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 256 BP 76 EP 77 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700257 ER PT J AU Fracisco, S Gettayacamin, M Tungtaeng, A Kozar, M O'Neil, M Craft, C Fernandes, P AF Fracisco, Susan Gettayacamin, Montip Tungtaeng, Anchalee Kozar, Michael O'Neil, Michael Craft, Carl Fernandes, Prabha TI ANTI-MALARIAL ACTIVITY OF CEM-101, A FLUOROKETOLIDE ANTIMICROBIAL, IN BOTH BLOOD STAGE AND PRESUMPTIVE CAUSAL PROPHYLACTIC MOUSE MODELS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Fracisco, Susan; Kozar, Michael; O'Neil, Michael] Walter Reed Army Inst Res Expt Therapeut, Silver Spring, MD USA. [Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Craft, Carl; Fernandes, Prabha] Cempra Pharmaceut Inc, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 265 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700265 ER PT J AU Gettayacamin, M Tungtaeng, A Imerbsin, R Sattabongkot, J Hansukjariya, P Komcharoen, S Inamnuay, L Hinds, SB Novak, JJ Fracisco, SD Dow, GS Lin, AJ Lanteri, CA Parriott, SK Ohrt, CK Kozar, MP O'Neil, MT Magill, AJ AF Gettayacamin, Montip Tungtaeng, Anchalee Imerbsin, Rawiwan Sattabongkot, Jetsumon Hansukjariya, Pranee Komcharoen, Srawuth Inamnuay, Laksanee Hinds, Sarah B. Novak, Joseph J. Fracisco, Susan D. Dow, Geoffrey S. Lin, Ai J. Lanteri, Charlotte A. Parriott, Sandi K. Ohrt, Colin K. Kozar, Michael P. O'Neil, Michael T. Magill, Alan J. TI ANIMAL MODELS FOR SCREENING OF EXOERYTHROCYTIC ANTIMALARIAL DRUGS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Gettayacamin, Montip; Tungtaeng, Anchalee; Imerbsin, Rawiwan; Hansukjariya, Pranee; Komcharoen, Srawuth; Inamnuay, Laksanee; Hinds, Sarah B.; Novak, Joseph J.] Armed Forces Res Inst Med Sci, Dept Vet Med, USA Med Component, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, USA Med Component, Bangkok 10400, Thailand. [Fracisco, Susan D.; Dow, Geoffrey S.; Lin, Ai J.; Lanteri, Charlotte A.; Parriott, Sandi K.; Ohrt, Colin K.; Kozar, Michael P.; O'Neil, Michael T.; Magill, Alan J.] Walter Reed Army Inst Res ET, Div Expt & Therapeut, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 266 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700266 ER PT J AU Smith, BL Obaldia, N Gerena, L Dow, GS AF Smith, Bryan L. Obaldia, Nicanor, III Gerena, Lucia Dow, Geoffrey S. TI THAI MULTIDRUG-RESISTANT (MDR) C2A STRAIN OF PLASMODIUM FALCIPARUM ADAPTED FOR USE IN THE AOTUS LEMURINUS IN VIVO MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Smith, Bryan L.; Gerena, Lucia; Dow, Geoffrey S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Obaldia, Nicanor, III] Gorgas Mem Inst Hlth Studies ICGES, Panama City, Panama. RI Obaldia, Nicanor/O-8460-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 268 BP 80 EP 80 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700268 ER PT J AU DiTusa, CA Gettayacamin, M Kozar, MP Lin, AJ Fracisco, SD Ohrt, C Magill, A AF DiTusa, Charles A. Gettayacamin, Montip Kozar, Michael P. Lin, Ai J. Fracisco, Susan D. Ohrt, Colin Magill, Alan TI PRIMAQUINE AND TAFENOQUINE IN THE PLASMODIUM CYNOMOLGI CAUSAL PROPHYLACTIC MALARIA MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [DiTusa, Charles A.; Kozar, Michael P.; Lin, Ai J.; Fracisco, Susan D.; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettayacamin, Montip] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 270 BP 81 EP 81 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700270 ER PT J AU Johnson, JD Harris, EH Kopydlowski, KM Hudson, TH Kozar, MP Hickman, MR O'Neil, MT AF Johnson, Jacob D. Harris, Erin H. Kopydlowski, Karen M. Hudson, Thomas H. Kozar, Michael P. Hickman, Mark R. O'Neil, Michael T. TI CHARACTERIZATION OF AN IN VITRO MALARIA LUMINESCENCE-BASED LIVER STAGE DRUG SENSITIVITY SCREEN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Johnson, Jacob D.; Harris, Erin H.; Hudson, Thomas H.; Kozar, Michael P.; Hickman, Mark R.; O'Neil, Michael T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kopydlowski, Karen M.] USA, Med Mat Dev Act, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 364 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700365 ER PT J AU Velmurugan, S Chattopadhyay, R Chakiath, C Magill, A O'Neil, M Milhous, W Barnwell, J Collins, WE Hoffman, SL AF Velmurugan, Soundarapandian Chattopadhyay, Rana Chakiath, Chinnamma Magill, Alan O'Neil, Michael Milhous, Wilbur Barnwell, John Collins, William E. Hoffman, Stephen L. TI HEPATOCYTE-BASED ASSAY TO ASSESS THE EFFECTS OF DRUGS ON THE PRE-ERYTHROCYTE STAGES OF PLASMODIUM VIVAX SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Velmurugan, Soundarapandian; Chattopadhyay, Rana; Chakiath, Chinnamma; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Magill, Alan; O'Neil, Michael; Milhous, Wilbur] Walter Reed Army Inst Res, Silver Spring, MD USA. [Barnwell, John; Collins, William E.] NCID, Ctr Dis Control & Prevent, Malaria Branch, Chamblee, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 365 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700366 ER PT J AU Walker, LA Tekwani, BL Nanayakkara, NPD Sampath, A Magill, A Ohrt, C AF Walker, Larry A. Tekwani, Babu L. Nanayakkara, N. P. Dhammika Sampath, Aruna Magill, Alan Ohrt, Colin TI PATHWAYS TO DISCOVERY OF NON-HEMOLYTIC 8-AMINOQUINOLINE ANTIMALARIALS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Walker, Larry A.; Tekwani, Babu L.; Nanayakkara, N. P. Dhammika] Univ Mississippi, University, MS 38677 USA. [Sampath, Aruna; Magill, Alan; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 368 BP 110 EP 110 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700369 ER PT J AU Kortepeter, MG Honko, A Johnson, JC Olinger, GG Purcell, BK Rivard, R Hepburn, MJ Hensley, LE Lawler, JV AF Kortepeter, Mark G. Honko, Anna Johnson, Joshua C. Olinger, Gene G. Purcell, Bret K. Rivard, Robert Hepburn, Matthew J. Hensley, Lisa E. Lawler, James V. TI PATHOPHYSIOLOGIC ASSESSMENT OF EBOLA VIRUS INFECTION WITH AND WITHOUT INTRAVENOUS FLUID TREATMENT IN A NONHUMAN PRIMATE MODEL USING A MULTI-SENSOR TELEMETRY SYSTEM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kortepeter, Mark G.; Honko, Anna; Johnson, Joshua C.; Olinger, Gene G.; Purcell, Bret K.; Rivard, Robert; Hepburn, Matthew J.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Lawler, James V.] NIAID, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 3 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 381 BP 114 EP 114 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700382 ER PT J AU Chansamut, N Buates, S Udomsangpetch, R Krasaesub, S Rachaphaew, N Takhampunya, R Sattabongkot, J AF Chansamut, Nakit Buates, Sureemas Udomsangpetch, Rachanee Krasaesub, Somporn Rachaphaew, Nattawan Takhampunya, Ratree Sattabongkot, Jetsumon TI CORRELATION OF AII-TUBULIN AND PFG377 ORTHOLOG GENE EXPRESSIONS IN PLASMODIUM VIVAX GAMETOCYTES AND MOSQUITO INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Chansamut, Nakit; Buates, Sureemas; Udomsangpetch, Rachanee] Mahidol Univ, Bangkok 10700, Thailand. [Krasaesub, Somporn; Rachaphaew, Nattawan; Takhampunya, Ratree; Sattabongkot, Jetsumon] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 398 BP 119 EP 119 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700399 ER PT J AU Wei, HH Deye, G Johnson, J Ishida, H Anova, L Myint, H Sampath, A Magill, A Walker, L Ohrt, C AF Wei, Hans H. Deye, Gregory Johnson, Jacob Ishida, Hiroshi Anova, Lalaine Myint, Hla Sampath, Aruna Magill, Alan Walker, Larry Ohrt, Colin TI TOWARD A RHESUS G-6PD DEFICIENT MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Wei, Hans H.; Deye, Gregory; Johnson, Jacob; Ishida, Hiroshi; Anova, Lalaine; Myint, Hla; Sampath, Aruna; Magill, Alan; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Walker, Larry] Univ Mississippi, Oxford, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 426 BP 127 EP 127 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700428 ER PT J AU Awandare, GA Spadafora, C Moch, JK Dutta, S Haynes, JD Stoute, JA AF Awandare, Gordon A. Spadafora, Carmenza Moch, J. Kathleen Dutta, Sheetij Haynes, J. David Stoute, Jose A. TI PLASMODIUM FALCIPARUM FIELD ISOLATES USE COMPLEMENT RECEPTOR 1 (CR1) AS A RECEPTOR FOR INVASION OF ERYTHROCYTES IN A COMPLEMENT-INDEPENDENT MANNER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Awandare, Gordon A.; Moch, J. Kathleen; Dutta, Sheetij; Haynes, J. David] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Spadafora, Carmenza] Inst Invest Cient & Serv Alta Tecnol AIP INDICASA, Ciudad Del Saber, Clayton, Panama. [Stoute, Jose A.] Penn State Univ, Coll Med, Div Infect Dis, Dept Med, Hershey, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 428 BP 128 EP 128 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700429 ER PT J AU Spadafora, C Awandare, G Kopydlowski, KM Czege, J Moch, JK Finberg, RW Tsokos, GC Stoute, JA AF Spadafora, Carmenza Awandare, Gordon Kopydlowski, Karen M. Czege, Jozsef Moch, J. Kathleen Finberg, Robert W. Tsokos, George C. Stoute, Jose A. TI COMPLEMENT RECEPTOR 1 IS THE "X" RECEPTOR (SIALIC ACID-INDEPENDENT) FOR PLASMODIUM FALCIPARUM IN THE HUMAN ERYTHROCYTE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Spadafora, Carmenza] Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Panama City, Panama. [Awandare, Gordon; Moch, J. Kathleen] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kopydlowski, Karen M.] USA, Med Mat Dev Acit, Ft Detrick, MD USA. [Czege, Jozsef] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Finberg, Robert W.] Univ Massachusetts, Sch Med, Boston, MA 02125 USA. [Tsokos, George C.] Harvard Univ, Sch Med, Boston, MD USA. [Stoute, Jose A.] Penn State Univ, Coll Med, Hershey, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 431 BP 129 EP 129 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700432 ER PT J AU Bodhidatta, L Neesanant, P Sornsakrin, S Taecharale, V Supawat, K Sethabutr, O Mason, CJ AF Bodhidatta, Ladaporn Neesanant, Pimmnapar Sornsakrin, Siriporn Taecharale, Vorachet Supawat, Krongkaew Sethabutr, Orntipa Mason, Carl J. TI NOROVIRUS INFECTION IN YOUNG CHILDREN IN THAILAND - A MULTICENTER STUDY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Bodhidatta, Ladaporn; Neesanant, Pimmnapar; Sornsakrin, Siriporn; Sethabutr, Orntipa; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Supawat, Krongkaew] Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 482 BP 144 EP 144 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700483 ER PT J AU Bodhidatta, L Shrestha, S Silapong, S Shrestha, BR Regmi, S Sethabutr, O Mason, CJ AF Bodhidatta, Ladaporn Shrestha, Sanjaya Silapong, Sasikorn Shrestha, Bhola Ram Regmi, Shanti Sethabutr, Orntipa Mason, Carl J. TI ROTAVIRUS DIARRHEA IN YOUNG CHILDREN IN BHARATPUR, NEPAL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Bodhidatta, Ladaporn; Silapong, Sasikorn; Sethabutr, Orntipa; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Shrestha, Sanjaya] Walter Reed Armed Forces Res Inst Med Sci, Res Unit Nepal, Kathmandu, Nepal. [Shrestha, Bhola Ram; Regmi, Shanti] Bharatpur Hosp, Bharatpur, Nepal. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 481 BP 144 EP 144 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700482 ER PT J AU Kuchuloria, T Clark, DV Akhvlediani, T Nanuashvili, A Makhviladze, M Kanashvili, M Tsertsvadze, T Endeladze, M Chokheli, M Chikviladze, T Chubinidze, M House, B Farrell, M Maksoud, MA Hepburn, MJ Pimentel, G AF Kuchuloria, Tinatin Clark, Danielle V. Akhvlediani, Tamar Nanuashvili, Alexander Makhviladze, Manana Kanashvili, Marine Tsertsvadze, Tengiz Endeladze, Marina Chokheli, Maiko Chikviladze, Tamar Chubinidze, Marine House, Brent Farrell, Margaret Maksoud, Mohamed Abdel Hepburn, Matthew J. Pimentel, Guillermo TI LABORATORY SURVEILLANCE FOR THE POSSIBLE INFECTIOUS CAUSES OF UNDIFFERENTIATED FEBRILE ILLNESSES IN THE COUNTRY OF GEORGIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kuchuloria, Tinatin; Akhvlediani, Tamar] I Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia. [Kuchuloria, Tinatin; Akhvlediani, Tamar] Technol Management Co, Tbilisi, Rep of Georgia. [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nanuashvili, Alexander] Serv Antimicrobial Chemotherapy, Tbilisi, Rep of Georgia. [Makhviladze, Manana; Kanashvili, Marine] V Bochorishvili Antisepsis Ctr, Tbilisi, Rep of Georgia. [Tsertsvadze, Tengiz; Endeladze, Marina] AIDS & Clin Immunol Res Ctr, Tbilisi, Rep of Georgia. [Chokheli, Maiko; Chikviladze, Tamar; Chubinidze, Marine] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [House, Brent; Farrell, Margaret; Maksoud, Mohamed Abdel; Pimentel, Guillermo] USN, Global Dis Detect & Response Program, Med Res Unit 3, Cairo, Egypt. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 504 BP 151 EP 151 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700505 ER PT J AU Ibadova, G Mamatkulov, A Abdukhalilova, G Madyarov, R Khodiev, A Mason, C Bidhidatta, L AF Ibadova, Gulnara Mamatkulov, Adkham Abdukhalilova, Gulnara Madyarov, Ruslan Khodiev, Aybek Mason, Carl Bidhidatta, Ladaporn TI PREVALENCE OF ROTAVIRUS AMONG PATIENTS WITH ACUTE DIARRHEA IN DIFFERENT REGIONS OF UZBEKISTAN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Ibadova, Gulnara] Tashkent Inst Postgrad Med Educ, Tashkent, Uzbekistan. [Mamatkulov, Adkham; Khodiev, Aybek] Technol Management Co, Tashkent, Uzbekistan. [Abdukhalilova, Gulnara; Madyarov, Ruslan] Epidemiol Microbiol & Infect Dis Res Inst, Tashkent, Uzbekistan. [Mason, Carl; Bidhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 506 BP 152 EP 152 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700507 ER PT J AU Lin, JT Bethell, DB Tyner, SD Saunders, DL Khemawoot, P Sriwichai, S Schaecher, K Socheat, D Meshnick, SR Se, Y Lon, C Fukuda, MM AF Lin, Jessica T. Bethell, Delia B. Tyner, Stuart D. Saunders, David L. Khemawoot, Phisit Sriwichai, Sabaithip Schaecher, Kurt Socheat, Duong Meshnick, Steven R. Se, Youry Lon, Chanthap Fukuda, Mark M. TI PLASMODIUM FALCIPARUM GAMETOCYTE CARRIAGE IS ASSOCIATED WITH SUBSEQUENT P. VIVAX RELAPSE AFTER TREATMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Lin, Jessica T.; Bethell, Delia B.; Tyner, Stuart D.; Saunders, David L.; Khemawoot, Phisit; Sriwichai, Sabaithip; Schaecher, Kurt; Se, Youry; Lon, Chanthap; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Meshnick, Steven R.] Univ N Carolina, Gillings Sch Publ Hlth, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 550 BP 165 EP 165 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700551 ER PT J AU Kamau, E Nyakoe, N Muringo, L Ockenhouse, CF Waitumbi, J AF Kamau, Edwin Nyakoe, Nancy Muringo, Linda Ockenhouse, Christian F. Waitumbi, John TI COMBINED RNA AND DNA RT-QPCR ASSAY FOR USE IN MALARIA DIAGNOSIS AND INTERVENTION TRIALS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kamau, Edwin; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nyakoe, Nancy; Muringo, Linda; Waitumbi, John] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 555 BP 167 EP 167 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700556 ER PT J AU Kuttasingkee, N Ruang-areerate, T Kaewsatien, P Somsri, K Youngpakool, K Indontri, B Chanchu, C Gaywee, J AF Kuttasingkee, Narupon Ruang-areerate, Toon Kaewsatien, Pradith Somsri, Kiatisak Youngpakool, Khwananong Indontri, Bungauang Chanchu, Chaiya Gaywee, Jariyanart TI ACTIVE SURVEILLANCE OF MALARIA IN MILITARY AREAS OF OPERATION (AOS) ALONG NORTHERN THAI-MYANMAR AND THAI-NORTHERN CAMBODIA BORDERS DURING 2004-2009 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kuttasingkee, Narupon; Ruang-areerate, Toon; Kaewsatien, Pradith; Somsri, Kiatisak; Youngpakool, Khwananong; Indontri, Bungauang; Chanchu, Chaiya; Gaywee, Jariyanart] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 574 BP 172 EP 172 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700575 ER PT J AU Patterson, NB Stefaniak, ME Gowda, K Farooq, F McGrath, S Konovalova, S Chen, P Semenova, E Grier, R Bruder, JT Limbach, K Richie, TL AF Patterson, Noelle B. Stefaniak, Maureen E. Gowda, Kalpana Farooq, Fouzia McGrath, Shannon Konovalova, Svetlana Chen, Ping Semenova, Elena Grier, Richard Bruder, Joseph T. Limbach, Keith Richie, Thomas L. TI HETEROLOGOUS ADENOVECTORED VACCINE REGIMENS ARE IMMUNOGENIC AND PROTECTIVE IN THE PLASMODIUM YOELII MOUSE MALARIA MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Patterson, Noelle B.; Stefaniak, Maureen E.; Farooq, Fouzia; Limbach, Keith] Henry M Jackson Fdn Adv Mil Med, Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [McGrath, Shannon] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Konovalova, Svetlana; Chen, Ping; Semenova, Elena; Grier, Richard; Bruder, Joseph T.] GenVec Inc, Gaithersburg, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 583 BP 175 EP 175 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700584 ER PT J AU Bergmann-Leitner, ES Leitner, WW Angov, E AF Bergmann-Leitner, Elke S. Leitner, Wolfgang W. Angov, Evelina TI COMPARISON OF PLASMODIUM BERGHEI CHALLENGE MODEL FOR THE EVALUATION OF PRE-ERYTHROCYTIC MALARIA VACCINES AND THEIR EFFECT ON PERCEIVED VACCINE EFFICACY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Leitner, Wolfgang W.] NIAID, NIH, Bethesda, MD 20892 USA. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 585 BP 176 EP 176 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700586 ER PT J AU Hosie, H Bergmann-Leitner, ES Trichilo, J Dake, C Alefantis, T Grewal, P DelVecchio, VG Angov, E AF Hosie, Heather Bergmann-Leitner, Elke S. Trichilo, Jessica Dake, Clarissa Alefantis, Tim Grewal, Paul DelVecchio, Vito G. Angov, Evelina TI INACTIVATED ESCHERICHIA COLI EXPRESS PROPERLY DISULFIDE-BRIDGED PLASMODIUM FALCIPARUM FVO MSP1-42 FROM DIFFERENT CELLULAR LOCALIZATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Hosie, Heather; Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Trichilo, Jessica; Dake, Clarissa; Alefantis, Tim; Grewal, Paul; DelVecchio, Vito G.] Vital Probes Inc, Mayfield, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 586 BP 176 EP 176 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700587 ER PT J AU Laurens, MB Thera, MA Coulibaly, D Kone, AK Guindo, AB Diallo, DA Traore, K Niangaly, A Dolo, A Tolo, Y Sissoko, MS Kouriba, B Lyke, KE Takala-Harrison, S Blackwelder, WC Wu, YK Vekemans, J Cohen, J Lanar, DE Dutta, S Diggs, CL Soisson, L Heppner, DG Doumbo, OK Plowe, CV Traore, I Diarra, I Daou, M Sissoko, M Godeaux, O Dubois, MC Ballou, R Thompson, D Dube, T House, B Bennett, JW AF Laurens, Matthew B. Thera, Mahamadou A. Coulibaly, Drissa Kone, Abdoulaye K. Guindo, Ando B. Diallo, Dapa A. Traore, Karim Niangaly, Amadou Dolo, Amagana Tolo, Youssouf Sissoko, Mahamadou S. Kouriba, Bourema Lyke, Kirsten E. Takala-Harrison, Shannon Blackwelder, William C. Wu, Yukun Vekemans, Johan Cohen, Joe Lanar, David E. Dutta, Sheetij Diggs, Carter L. Soisson, Lorraine Heppner, D. Gray Doumbo, Ogobara K. Plowe, Christopher V. Traore, Idrissa Diarra, Issa Daou, Modibo Sissoko, Mady Godeaux, Olivier Dubois, Marie-Claude Ballou, Ripley Thompson, Darby Dube, Tina House, Brent Bennett, Jason W. TI EFFICACY OF FMP2.1/AS02A AGAINST GAMETOCYTEMIA IN 1-6 YEAR OLD CHILDREN IN BANDIAGARA, MALI: IMPLICATIONS FOR MALARIA ELIMINATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Thera, Mahamadou A.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Diallo, Dapa A.; Traore, Karim; Niangaly, Amadou; Dolo, Amagana; Tolo, Youssouf; Sissoko, Mahamadou S.; Kouriba, Bourema; Doumbo, Ogobara K.] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. [Vekemans, Johan; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Diggs, Carter L.; Soisson, Lorraine] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 590 BP 177 EP 177 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700591 ER PT J AU Masuoka, PM Klein, TA Kim, HC Claborn, DM Achee, N Andre, R Chamberlin, J Small, J Anyamba, A Lee, DK Yi, SH Sardelis, M Grieco, J AF Masuoka, Penny M. Klein, Terry A. Kim, Heung-Chul Claborn, David M. Achee, Nicole Andre, Richard Chamberlin, Judith Small, Jennifer Anyamba, Assaf Lee, Dong-Kyu Yi, Suk H. Sardelis, Michael Grieco, John TI MODELING CULEX TRITAENIORHYNCHUS MOSQUITOES TO PREDICT THE GEOGRAPHIC DISTRIBUTION OF JAPANESE ENCEPHALITIS IN THE REPUBLIC OF KOREA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Masuoka, Penny M.; Achee, Nicole; Andre, Richard; Chamberlin, Judith; Grieco, John] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Klein, Terry A.; Kim, Heung-Chul; Yi, Suk H.] 65th Med Brigade US Army MEDDAC Korea, Seoul, South Korea. [Claborn, David M.] Missouri State Univ, Ctr Homeland Secur, Springfield, MO USA. [Small, Jennifer; Anyamba, Assaf] NASAs Goddard Space Flight Ctr, Hydrol & Biospher Sci Lab, Greenbelt, MD USA. [Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan, South Korea. [Sardelis, Michael] Natl Ctr Med Intelligence, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 607 BP 182 EP 182 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700608 ER PT J AU Sakpaisal, P Ruang-areerate, T Kuttasingkee, N Sangjun, N Somsri, K Koewsathit, J Youngpakool, K Kaewsatien, P Chanchu, C Gaywee, J AF Sakpaisal, Pimmada Ruang-areerate, Toon Kuttasingkee, Narupon Sangjun, Nopadol Somsri, Kiatisak Koewsathit, Jittasak Youngpakool, Khwananong Kaewsatien, Pradith Chanchu, Chaiya Gaywee, Jariyanart TI SURVEY OF RICKETTSIAL VECTORS AND RESERVOIR HOSTS IN MILITARY AREAS OF OPERATION (AOS) ALONG NORTHERN THAI-MYANMAR AND THAI-CAMBODIA BORDERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Sakpaisal, Pimmada; Ruang-areerate, Toon; Kuttasingkee, Narupon; Sangjun, Nopadol; Somsri, Kiatisak; Youngpakool, Khwananong; Kaewsatien, Pradith; Chanchu, Chaiya; Gaywee, Jariyanart] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Koewsathit, Jittasak] Chulalongkorn Univ, Fac Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 627 BP 187 EP 187 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819700628 ER PT J AU Takhampunya, R Kengluecha, A Monkanna, T Evans, BP Richardson, JH AF Takhampunya, Ratree Kengluecha, Ampornpan Monkanna, Taweesak Evans, Brian P. Richardson, Jason H. TI GENOTYPE IDENTIFICATION AND SEQUENCE ANALYSIS OF ORIENTIA TSUTSUGAMUSHI ISOLATED FROM SCRUB TYPHUS-INFECTED CHIGGER-MITE COLONIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Takhampunya, Ratree; Kengluecha, Ampornpan; Monkanna, Taweesak; Evans, Brian P.; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 656 BP 196 EP 196 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701025 ER PT J AU Mendez, J Brasov, IE Diao, LY Tally, J Grogl, M Weina, PJ AF Mendez, Juan Brasov, Ioana E. Diao, Li Y. Tally, John Grogl, Max Weina, Peter J. TI SEVEN YEARS OF DATA COLLECTION AND ANALYSIS FOR THE LEISHMANIA DIAGNOSTIC LABORATORY AT WALTER REED ARMY INSTITUTE OF RESEARCH SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Mendez, Juan; Brasov, Ioana E.; Diao, Li Y.; Tally, John; Grogl, Max; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 694 BP 207 EP 207 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701063 ER PT J AU Miller, AK Mohamed, K Ye, L Harrell, E Baptiste-Brown, S Kleim, JP Ohrt, C Duparc, S Beelen, A Webster, A Griffith, S AF Miller, Ann K. Mohamed, Khadeeja Ye, Li Harrell, Emma Baptiste-Brown, Sharon Kleim, Joerg-Peter Ohrt, Colin Duparc, Stephan Beelen, Andrew Webster, Alison Griffith, Sandy TI PHARMACOKINETICS (PK) AND QTC CHANGES AFTER COADMINISTRATION OF TAFENOQUINE (TQ) AND CHLOROQUINE (CQ) IN HEALTHY VOLUNTEERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Miller, Ann K.; Baptiste-Brown, Sharon] GlaxoSmithKline Inc, King Of Prussia, PA USA. [Mohamed, Khadeeja; Kleim, Joerg-Peter; Webster, Alison] GlaxoSmithKline Inc, Uxbridge, Middx, England. [Ye, Li] GlaxoSmithKline Inc, Collegeville, PA USA. [Harrell, Emma] GlaxoSmithKline Inc, Harlow, Essex, England. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Duparc, Stephan] Med Malaria Venture, Geneva, Switzerland. [Beelen, Andrew] Miriad Pharmaceut, Salt Lake City, UT USA. [Griffith, Sandy] GlaxoSmithKline Inc, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 711 BP 211 EP 212 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701079 ER PT J AU Rothstein, Y Johnson, J Sampath, A Ellis, W Nanayakkara, D Khan, I Walker, L Magill, A Ohrt, CK AF Rothstein, Yarrow Johnson, Jacob Sampath, Aruna Ellis, William Nanayakkara, Dhammika Khan, Ikhlas Walker, Larry Magill, Alan Ohrt, Colin K. TI ACTIVITY OF 8-AMINOQUINOLINE (8AQ) ANTIMALARIAL DRUG CANDIDATES AGAINST BLOOD STAGE PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Rothstein, Yarrow; Johnson, Jacob; Sampath, Aruna; Ellis, William; Magill, Alan; Ohrt, Colin K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nanayakkara, Dhammika; Khan, Ikhlas; Walker, Larry] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 710 BP 211 EP 211 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701078 ER PT J AU Gutteridge, CE Baxter, MC Hughes, SM Sadowski, BW Rodrigo, LG Smith, MB O'Neil, MT McCalmont, WF Gerena, L Montip, G AF Gutteridge, Clare E. Baxter, Michael C. Hughes, Stephen M. Sadowski, Brett W. Rodrigo, Leighton G. Smith, Matthew B. O'Neil, Michael T. McCalmont, William F. Gerena, Lucia Montip, Gettayacamin TI DEVELOPMENT OF A NOVEL CHEMICAL SERIES WITH ACTIVITY AGAINST BOTH BLOOD- AND LIVER-STAGES OF PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Gutteridge, Clare E.; Baxter, Michael C.; Hughes, Stephen M.; Sadowski, Brett W.; Rodrigo, Leighton G.; Smith, Matthew B.] USN Acad, Annapolis, MD 21402 USA. [O'Neil, Michael T.; McCalmont, William F.; Gerena, Lucia] Walter Reed Army Inst Res, Silver Spring, MD USA. [Montip, Gettayacamin] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 712 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701080 ER PT J AU Tekwani, BL Chaurasiya, ND Sahu, R Adelli, VR Nanayakkara, NPD Sampath, A Ohrt, C Walker, LA AF Tekwani, Babu L. Chaurasiya, Narayan D. Sahu, Rajnish Adelli, Vijendar R. Nanayakkara, N. P. Dhammika Sampath, Aruna Ohrt, Colin Walker, Larry A. TI SUSCEPTIBILITY OF NORMAL AND GLUCOSE 6-PHOSPHATE DEHYDROGENASE DEFICIENT HUMAN ERYTHROCYTES TO PRIMAQUINE ENANTIOMERS AND POTENTIAL HEMOTOXIC METABOLITES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Tekwani, Babu L.; Chaurasiya, Narayan D.; Sahu, Rajnish; Adelli, Vijendar R.; Nanayakkara, N. P. Dhammika; Walker, Larry A.] Univ Mississippi, University, MS 38677 USA. [Sampath, Aruna; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 713 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701081 ER PT J AU Dow, GS Milner, E Caridha, D Gardner, S Lanteri, C Kozar, M Mannila, A McCalmont, W Melendez, V Moon, J Read, K Norval, S Roncal, N Shackleford, D Sousa, J Stouten, J White, K Zeng, Q Charman, S AF Dow, Geoffrey S. Milner, Erin Caridha, Diana Gardner, Sean Lanteri, Charlotte Kozar, Michael Mannila, Ann McCalmont, William Melendez, Victor Moon, Jay Read, Kevin Norval, Suzanne Roncal, Norma Shackleford, David Sousa, Jason Stouten, Jessica White, Karen Zeng, Qiang Charman, Susan TI CENTRAL NERVOUS SYSTEM (CNS) EXPOSURE OF NEXT GENERATION QUINOLINE METHANOLS IS REDUCED RELATIVE TO MEFLOQUINE AFTER INTRAVENOUS (IV) DOSING IN MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Dow, Geoffrey S.; Milner, Erin; Caridha, Diana; Gardner, Sean; Lanteri, Charlotte; Kozar, Michael; McCalmont, William; Melendez, Victor; Moon, Jay; Roncal, Norma; Sousa, Jason; Zeng, Qiang] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mannila, Ann; Shackleford, David; Stouten, Jessica; White, Karen; Charman, Susan] Monash Univ, Ctr Drug Candidate Optimisat, Melbourne, Vic 3004, Australia. [Read, Kevin; Norval, Suzanne] Univ Dundee, Dundee, Scotland. NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 715 BP 213 EP 213 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701083 ER PT J AU Kelly, JX Li, YX Forquer, I Melendez, V Hickman, M O'Neil, M Cooper, R Harris, E Pybus, B Sousa, J Li, QG Smilkstein, M Winter, R Hinrichs, D Riscoe, M AF Kelly, Jane X. Li, Yuexin Forquer, Isaac Melendez, Victor Hickman, Mark O'Neil, Michael Cooper, Roland Harris, Erin Pybus, Brandon Sousa, Jason Li, Qigui Smilkstein, Martin Winter, Rolf Hinrichs, Dave Riscoe, Mike TI NOVEL ACRIDONES AS BROAD-SPECTRUM ANTIMALARIALS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kelly, Jane X.] Portland State Univ, Portland, OR 97207 USA. [Li, Yuexin; Forquer, Isaac; Winter, Rolf; Hinrichs, Dave; Riscoe, Mike] Portland VA Med Ctr, Portland, OR USA. [Melendez, Victor; Hickman, Mark; O'Neil, Michael; Harris, Erin; Pybus, Brandon; Sousa, Jason; Li, Qigui] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cooper, Roland] Old Dominion Univ, Norfolk, VA USA. [Smilkstein, Martin] Oregon Translat Res & Drug Dev Inst, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 716 BP 213 EP 213 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701084 ER PT J AU Rochford, R Othoro, C Sampath, A Mauro, M Tekwani, B Ohrt, C Walker, L AF Rochford, Rosemary Othoro, Caroline Sampath, Aruna Mauro, Marino Tekwani, Babu Ohrt, Colin Walker, Larry TI A HUMANIZED MOUSE MODEL TO TEST HEMOLYTIC TOXICITY OF 8-AMINOQUINOLINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Rochford, Rosemary; Othoro, Caroline; Mauro, Marino] SUNY Syracuse, Syracuse, NY USA. [Sampath, Aruna; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tekwani, Babu; Walker, Larry] Univ Mississippi, Oxford, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 717 BP 213 EP 213 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701085 ER PT J AU Ouattara, A Takala-Harrison, S Coulibaly, D Thera, MA Laurens, MB Niangaly, A Saye, R Dutta, S Heppner, GD Soisson, L Diggs, CL Vekemans, J Cohen, J Leach, A Blackwelder, WC Doumbo, OK Plowe, CV AF Ouattara, Amed Takala-Harrison, Shannon Coulibaly, Drissa Thera, Mahamadou A. Laurens, Matthew B. Niangaly, Amadou Saye, Renion Dutta, Sheetij Heppner, D. Gray Soisson, Lorraine Diggs, Carter L. Vekemans, Johan Cohen, Joe Leach, Amanda Blackwelder, William C. Doumbo, Ogobara K. Plowe, Christopher V. TI ALLELE-SPECIFIC EFFICACY OF THE MONOVALENT APICAL MEMBRANE ANTIGEN 1 (AMA1) MALARIA VACCINE FMP2.1/AS02A SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Coulibaly, Drissa; Thera, Mahamadou A.; Niangaly, Amadou; Saye, Renion; Doumbo, Ogobara K.] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. [Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [Vekemans, Johan; Cohen, Joe; Leach, Amanda] GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 803 BP 238 EP 238 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701171 ER PT J AU Epstein, JE Lyke, KE Laurens, MB Reyes, S Tamminga, C Sedegah, M Thomas, N Murphy, J Billingsley, PF James, E Gunasekera, A Anderson, C Chakravarty, S Richman, A Li, M Ahumada, A Komisar, J Bennett, J Brandt, W Plowe, CV Ockenhouse, CF Sim, BKL Edelman, R Richie, TL Hoffman, SL AF Epstein, Judith E. Lyke, Kirsten E. Laurens, Matthew B. Reyes, Sharina Tamminga, Cindy Sedegah, Martha Thomas, Nicole Murphy, Jittawadee Billingsley, Peter F. James, Eric Gunasekera, Anusha Anderson, Charles Chakravarty, Sumana Richman, Adam Li, Ming Ahumada, Adriana Komisar, Jack Bennett, Jason Brandt, Walter Plowe, Christopher V. Ockenhouse, Christian F. Sim, B. Kim Lee Edelman, Robert Richie, Thomas L. Hoffman, Stephen L. TI THE FIRST PHASE 1/2A TRIAL OF THE METABOLICALLY-ACTIVE, WHOLE ORGANISM PLASMODIUM FALCIPARUM SPOROZOITE (PFSPZ) VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Epstein, Judith E.; Reyes, Sharina; Tamminga, Cindy; Sedegah, Martha; Thomas, Nicole; Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA. [Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Murphy, Jittawadee; Komisar, Jack; Bennett, Jason; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Billingsley, Peter F.; James, Eric; Gunasekera, Anusha; Anderson, Charles; Chakravarty, Sumana; Richman, Adam; Li, Ming; Ahumada, Adriana; Sim, B. Kim Lee; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Brandt, Walter] PATH Malaria Vaccine Initiat, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 807 BP 239 EP 240 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701175 ER PT J AU Sedegah, M Chuang, IL McGrath, S House, B Ganeshan, H Lejano, J Abot, E Banania, G Sayo, R Farooq, F Belmonte, M Richie, NO Wood, C Long, CA Regis, D Tamminga, C Spring, M Limbach, K Patterson, NB Bruder, J Doolan, DL Soisson, L Diggs, C Ockenhouse, CF Richie, TL AF Sedegah, Martha Chuang, Ilin McGrath, Shannon House, Brent Ganeshan, Harini Lejano, Jennylynn Abot, Esteban Banania, Glenna Sayo, Renato Farooq, Fouzia Belmonte, Maria Richie, Nancy O. Wood, Chloe Long, Carole A. Regis, David Tamminga, Cindy Spring, Michele Limbach, Keith Patterson, Noelle B. Bruder, Joe Doolan, Denise L. Soisson, Lorraine Diggs, Carter Ockenhouse, Christian F. Richie, Thomas L. TI ANALYSIS OF CELL-MEDIATED IMMUNE RESPONSES IN VOLUNTEERS STERILELY PROTECTED AGAINST PLASMODIUM FALCIPARUM SPOROZOITE CHALLENGE FOLLOWING IMMUNIZATION WITH A GENE-BASED VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Sedegah, Martha; Chuang, Ilin; House, Brent; Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna; Sayo, Renato; Farooq, Fouzia; Belmonte, Maria; Regis, David; Tamminga, Cindy; Limbach, Keith; Patterson, Noelle B.; Richie, Thomas L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [McGrath, Shannon; Richie, Nancy O.; Wood, Chloe; Spring, Michele; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Bruder, Joe] GenVec Inc, Gaithersburg, MD USA. [Doolan, Denise L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. RI Doolan, Denise/F-1969-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 806 BP 239 EP 239 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701174 ER PT J AU Chuang, I Sattabongkot, J Fryauff, D Tosh, D Murphy, J Saunders, D Richardson, J William, J Bethel, D Richie, T Ware, L Spring, M Fukuda, M Tamminga, C Guerrero, M Bennett, J Cummings, J Yadava, A Komisar, J Polhemus, M Ockenhouse, C AF Chuang, Ilin Sattabongkot, Jetsumon Fryauff, David Tosh, Donna Murphy, Jittawadee Saunders, David Richardson, Jason William, Jack Bethel, Delia Richie, Thomas Ware, Lisa Spring, Michele Fukuda, Mark Tamminga, Cindy Guerrero, Melanie Bennett, Jason Cummings, James Yadava, Anjali Komisar, Jack Polhemus, Mark Ockenhouse, Christian TI DEVELOPMENT OF A SAFE AND REPRODUCIBLE HUMAN SPOROZOITE CHALLENGE MODEL FOR PLASMODIUM VIVAX IN HEALTHY ADULTS IN THE UNITED STATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Chuang, Ilin; Fryauff, David; Richie, Thomas; Tamminga, Cindy; Polhemus, Mark] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA. [Sattabongkot, Jetsumon; Saunders, David; Richardson, Jason; Bethel, Delia] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Tosh, Donna; Guerrero, Melanie; Cummings, James] Walter Reed Army Inst Res, Clin Trials Ctr, Silver Spring, MD USA. [Murphy, Jittawadee; William, Jack] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Ware, Lisa; Spring, Michele; Bennett, Jason; Yadava, Anjali; Komisar, Jack; Ockenhouse, Christian] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 808 BP 240 EP 240 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701176 ER PT J AU Talley, AK Healy, SA Finney, OC Murphy, SC Wang, RB Kappe, SH Murphy, JR Ockenhouse, CF Heppner, DG Duffy, PE AF Talley, Angela K. Healy, Sara A. Finney, Olivia C. Murphy, Sean C. Wang, Ruobing Kappe, Stefan H. Murphy, Jittawadee R. Ockenhouse, Chris F. Heppner, Donald G. Duffy, Patrick E. TI ESTABLISHING THE MALARIA HUMAN CHALLENGE MODEL IN A NEW REGULATORY ENVIRONMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Talley, Angela K.; Finney, Olivia C.; Wang, Ruobing; Kappe, Stefan H.; Duffy, Patrick E.] Seattle Biomed Res Inst, Malaria Clin Trials Ctr, Seattle, WA 98109 USA. [Healy, Sara A.] Univ Washington, Dept Pediat, Div Pediat Infect Dis, Med Ctr, Seattle, WA 98195 USA. [Murphy, Sean C.] Univ Washington, Dept Lab Med, Med Ctr, Seattle, WA 98195 USA. [Murphy, Jittawadee R.; Ockenhouse, Chris F.; Heppner, Donald G.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 809 BP 240 EP 240 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701177 ER PT J AU Anderson, KB Thomas, SJ Gibbons, RV Rothman, AL Nisalak, A Berkelman, RL Libraty, DH Endy, TP AF Anderson, Kathryn B. Thomas, Stephen J. Gibbons, Robert V. Rothman, Alan L. Nisalak, Ananda Berkelman, Ruth L. Libraty, Daniel H. Endy, Timothy P. TI PRE-EXISTING IMMUNITY TO JAPANESE ENCEPHALITIS VIRUS IS ASSOCIATED WITH AN INCREASED RISK OF SYMPTOMATIC ILLNESS FOLLOWING A DENGUE VIRUS INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Anderson, Kathryn B.; Berkelman, Ruth L.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Thomas, Stephen J.; Gibbons, Robert V.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Rothman, Alan L.; Libraty, Daniel H.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Endy, Timothy P.] Upstate Med Univ, SUNY, Dept Med, Div Infect Dis, Syracuse, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 837 BP 249 EP 249 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701205 ER PT J AU Tamminga, C Epstein, JE Kronmann, K Wells, N Ockenhouse, CF Richie, TL AF Tamminga, Cindy Epstein, Judith E. Kronmann, Karl Wells, Natalie Ockenhouse, Christian F. Richie, Thomas L. TI THE IMPACT OF MALARIA ON THE UNITED STATES MILITARY: SEPTEMBER 2001 TO PRESENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Tamminga, Cindy; Epstein, Judith E.; Richie, Thomas L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Kronmann, Karl] Ghana Detachment, Naval Med Res Unit 3, Legon, Ghana. [Wells, Natalie] USN, Environm Prevent Med Unit 2, Norfolk, VA USA. [Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 971 BP 290 EP 290 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701338 ER PT J AU Carter, J Pool, C Bozick, BA De la Vega, P Angov, E Spaccapelo, R Crisanti, A Murphy, JR Ockenhouse, CF Dutta, S AF Carter, Jennifer Pool, Christopher Bozick, Brooke A. De la Vega, Particia Angov, Evelina Spaccapelo, Roberta Crisanti, Andrea Murphy, Jittawadee R. Ockenhouse, Christian F. Dutta, Sheetij TI BIOPHYSICAL AND IMMUNOLOGICAL STUDIES WITH A RECOMBINANT PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN (PFCSP) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Carter, Jennifer; Pool, Christopher; Bozick, Brooke A.; De la Vega, Particia; Angov, Evelina; Murphy, Jittawadee R.; Ockenhouse, Christian F.; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Spaccapelo, Roberta] Univ Perugia, I-06100 Perugia, Italy. [Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 978 BP 292 EP 292 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701345 ER PT J AU Dutta, S Dlugosz, L Haynes, JD Pool, CD Anders, RF Foley, M Batchelor, A AF Dutta, Sheetij Dlugosz, Lisa Haynes, John D. Pool, Christopher D. Anders, Robin F. Foley, Mick Batchelor, Adrian TI PROGRESS ON THE DEVELOPMENT OF A SECOND GENERATION PAN-REACTIVE APICAL MEMBRANE ANTIGEN-1 VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Dutta, Sheetij; Dlugosz, Lisa; Haynes, John D.; Pool, Christopher D.; Batchelor, Adrian] Walter Reed Army Inst Res, Silver Spring, MD USA. [Anders, Robin F.; Foley, Mick] La Trobe Univ, Bundoora, Vic, Australia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 980 BP 293 EP 293 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701347 ER PT J AU Spring, M Chuang, I Nielsen, R Hunter, K Brunell, M Waterman, P Polhemus, M Ockenhouse, C AF Spring, Michele Chuang, Ilin Nielsen, Robin Hunter, Kari Brunell, Marla Waterman, Paige Polhemus, Mark Ockenhouse, Christian TI REVIEW OF THE HUMAN MALARIA CHALLENGE MODEL AT THE WALTER REED ARMY INSTITUTE OF RESEARCH FROM 1995-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Spring, Michele; Chuang, Ilin; Ockenhouse, Christian] US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Nielsen, Robin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Hunter, Kari; Brunell, Marla] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Waterman, Paige] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Polhemus, Mark] US Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 981 BP 293 EP 293 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701348 ER PT J AU Chuang, I Sedegah, M Cicatelli, S Spring, M Tamminga, C Bennett, J Guerrero, M Polhemus, M Cummings, J Angov, E Bruder, J Patterson, N Limbach, K Bergmann-Leitner, E Murphy, J Soisson, L Diggs, C Ockenhouse, C Richie, T AF Chuang, Ilin Sedegah, Martha Cicatelli, Susan Spring, Michele Tamminga, Cindy Bennett, Jason Guerrero, Melanie Polhemus, Mark Cummings, James Angov, Evelina Bruder, Joe Patterson, Noelle Limbach, Keith Bergmann-Leitner, Elke Murphy, Jittawadee Soisson, Lorraine Diggs, Carter Ockenhouse, Christian Richie, Thomas TI PHASE 1/2A CLINICAL TRIAL ON SAFETY, TOLERABILITY, IMMUNOGENICITY AND EFFICACY OF PRIME BOOST REGIMEN OF DNA- AND ADENOVIRUS-VECTORED MALARIA VACCINES ENCODING PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN (CSP) AND APICAL MEMBRANE ANTIGEN (AMA1) IN MALARIA-NAIVE ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Chuang, Ilin; Sedegah, Martha; Tamminga, Cindy; Patterson, Noelle; Limbach, Keith; Richie, Thomas] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD USA. [Cicatelli, Susan; Guerrero, Melanie; Cummings, James] Walter Reed Army Inst Res, Clin Trials Ctr, Silver Spring, MD USA. [Spring, Michele; Bennett, Jason; Angov, Evelina; Bergmann-Leitner, Elke; Ockenhouse, Christian] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Polhemus, Mark] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Bruder, Joe] GenVec, Gaithersburg, MD USA. [Murphy, Jittawadee] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 984 BP 294 EP 294 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701351 ER PT J AU Mende, K Galloway, RL Becker, S Beckius, ML Murray, CK Hospenthal, DR AF Mende, Katrin Galloway, Renee L. Becker, Sara Beckius, Miraim L. Murray, Clinton K. Hospenthal, Duane R. TI INTER-LABORATORY AGREEMENT OF PULSED-FIELD GEL ELECTROPHORESIS IDENTIFICATION OF LEPTOSPIRA SEROVARS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Mende, Katrin; Becker, Sara; Beckius, Miraim L.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Galloway, Renee L.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1034 BP 309 EP 309 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701401 ER PT J AU Maranich, AM Murray, CK Mende, K Yu, X Beckius, ML Hospenthal, DR AF Maranich, Ashley M. Murray, Clinton K. Mende, Katrin Yu, Xin Beckius, Miriam L. Hospenthal, Duane R. TI DETECTION OF LEPTOSPIRA FROM SPIKED BLOOD AND URINE SAMPLES DRIED ONTO WHATMAN FTATM MATRIX CARDS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Maranich, Ashley M.; Murray, Clinton K.; Mende, Katrin; Yu, Xin; Beckius, Miriam L.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1037 BP 310 EP 310 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701404 ER PT J AU Myint, KS Gibbons, RV Kipar, A Perng, GC Mongkolsirichaikul, D Van Gesser, Y Solomon, T AF Myint, Khin S. Gibbons, Robert V. Kipar, Anja Perng, Guey C. Mongkolsirichaikul, Duangrat Van Gesser, Yvonne Solomon, Tom TI ASTROCYTE ACTIVATION IN JAPANESE ENCEPHALITIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Myint, Khin S.; Gibbons, Robert V.; Mongkolsirichaikul, Duangrat; Van Gesser, Yvonne] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kipar, Anja; Solomon, Tom] Univ Liverpool, Liverpool L69 3BX, Merseyside, England. [Perng, Guey C.] Emory Univ, Sch Med, Atlanta, GA USA. RI Kipar, Anja/L-7214-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1049 BP 313 EP 313 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701416 ER PT J AU Leed, SE Jirage, D O'Neil, MT Hickman, MR Grogl, M Johnson, JD AF Leed, Susan E. Jirage, Dayadevi O'Neil, Michael T. Hickman, Mark R. Grogl, Max Johnson, Jacob D. TI DEVELOPMENT OF LUMINESCENCE-BASED LEISHMANIA INTRACELLULAR AMASTIGOTE ASSAY FOR DRUG SCREENING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Leed, Susan E.; Jirage, Dayadevi; O'Neil, Michael T.; Hickman, Mark R.; Grogl, Max; Johnson, Jacob D.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1092 BP 326 EP 326 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701459 ER PT J AU Kamau, E Tolbert, L Jones, S Waitumbi, J Ockenhouse, CF AF Kamau, Edwin Tolbert, LaDonna Jones, Samantha Waitumbi, John Ockenhouse, Christian F. TI DEVELOPMENT OF AN ALLELIC DISCRIMINATION ASSAY FOR GENOTYPING SINGLE-NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH PLASMODIUM FALCIPARUM DRUG RESISTANCE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Kamau, Edwin; Tolbert, LaDonna; Jones, Samantha; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Waitumbi, John] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1098 BP 328 EP 328 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701465 ER PT J AU Lin, JT Juliano, JJ Sattabongkot, J Meshnick, SR AF Lin, Jessica T. Juliano, Jonathan J. Sattabongkot, Jetsumon Meshnick, Steven R. TI MEASURING GENETIC COMPLEXITY OF PLASMODIUM VIVAX INFECTIONS BY A HETERODUPLEX TRACKING ASSAY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Lin, Jessica T.; Juliano, Jonathan J.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Meshnick, Steven R.] Univ N Carolina, Gillings Sch Publ Hlth, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1108 BP 331 EP 331 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701475 ER PT J AU Brando, C McCoy, ME Kaba, SA Guo, Q Dasgupta, D Golden, H Mittelholzer, C Pimentel, TA Yang, YK Burkhard, P Lanar, DE AF Brando, Clara McCoy, Margaret E. Kaba, Stephen A. Guo, Qin Dasgupta, Debleena Golden, Hannah Mittelholzer, Christian Pimentel, Tais A. Yang, Yongkun Burkhard, Peter Lanar, David E. TI POLYPEPTIDE NANOPARTICLES GENERATE CD8(+) T-CELL RESPONSES IN THE ABSENCE OF ADJUVANT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Brando, Clara; McCoy, Margaret E.; Kaba, Stephen A.; Guo, Qin; Dasgupta, Debleena; Golden, Hannah; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mittelholzer, Christian] Univ Basel, Biozentrum, ME Muller Inst, Basel, Switzerland. [Lanar, David E.] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA. [Pimentel, Tais A.; Yang, Yongkun; Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1175 BP 349 EP 349 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701542 ER PT J AU Lumsden, JM Nurmukhambetova, S Klein, JH Bertholet, S Fox, CB Howard, RF Reed, SG Polhemus, ME Ockenhouse, CF Yadava, A AF Lumsden, Joanne M. Nurmukhambetova, Saule Klein, Jennifer H. Bertholet, Sylvie Fox, Christopher B. Howard, Randall F. Reed, Steven G. Polhemus, Mark E. Ockenhouse, Christian F. Yadava, Anjali TI EVALUATION OF IMMUNE RESPONSES TO A PLASMODIUM VIVAX CSP-BASED RECOMBINANT PROTEIN VACCINE CANDIDATE IN COMBINATION WITH SECOND-GENERATION ADJUVANTS IN MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Lumsden, Joanne M.; Nurmukhambetova, Saule; Klein, Jennifer H.; Polhemus, Mark E.; Ockenhouse, Christian F.; Yadava, Anjali] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bertholet, Sylvie; Fox, Christopher B.; Howard, Randall F.; Reed, Steven G.] IDRI, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1174 BP 349 EP 349 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701541 ER PT J AU McCoy, A Husain, T Angov, E Narum, D Bruder, J Stoyanov, C Trager, L Flynn, B Tewari, K Leitner, E Komisar, J Ockenhouse, C Richie, T Weiss, W Seder, R AF McCoy, Andrea Husain, Tupur Angov, Evelina Narum, David Bruder, Joseph Stoyanov, Cristina Trager, Lauren Flynn, Barbara Tewari, Kavita Leitner, Elke Komisar, Jack Ockenhouse, Christian Richie, Thomas Weiss, Walter Seder, Robert TI PRIME-BOOST MALARIA VACCINES IN RHESUS MONKEYS USING PROTEIN IN POLY I:C ADJUVANT AND ADENOVIRUS VECTORS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [McCoy, Andrea; Husain, Tupur; Richie, Thomas; Weiss, Walter] USN, Med Res Ctr, Silver Spring, MD USA. [Angov, Evelina; Leitner, Elke; Komisar, Jack; Ockenhouse, Christian] Walter Reed Army Inst Res, Silver Spring, MD USA. [Narum, David; Stoyanov, Cristina; Trager, Lauren; Flynn, Barbara; Tewari, Kavita; Seder, Robert] NIH, Bethesda, MD 20892 USA. [Bruder, Joseph] GenVec Inc, Gaithersburg, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1173 BP 349 EP 349 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701540 ER PT J AU Bethell, D Se, Y Lon, C Saunders, D Darapiseth, S Sriwichai, S Lin, J Timmermans, A Itveerakul, M Sarim, S Tyner, S Socheat, D Fukuda, M AF Bethell, Delia Se, Youry Lon, Chanthap Saunders, David Darapiseth, Sea Sriwichai, Sabaithip Lin, Jessica Timmermans, Ans Itveerakul, Mali Sarim, Ses Tyner, Stuart Socheat, Duong Fukuda, Mark TI ADVERSE EVENT PROFILE OF SEVEN-DAY COURSES OF ARTESUNATE IN PATIENTS WITH ACUTE FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Bethell, Delia; Se, Youry; Lon, Chanthap; Saunders, David; Sriwichai, Sabaithip; Lin, Jessica; Timmermans, Ans; Itveerakul, Mali; Tyner, Stuart; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Darapiseth, Sea; Socheat, Duong] Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Sarim, Ses] Tasanh Hlth Ctr, Samlot, Cambodia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1247 BP 371 EP 371 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701614 ER PT J AU Myint, HY Ohrt, C Walker, L White, N Magill, A AF Myint, Hla Yin Ohrt, Colin Walker, Larry White, Nick Magill, Alan TI A SURVEY ON CLINICAL SAFETY OF 8-AMINOQUINOLINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Myint, Hla Yin; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Walker, Larry] Univ Mississippi, University, MS 38677 USA. [White, Nick] Mahidol Univ, Mahidol Oxford Res Unit, Bangkok 10700, Thailand. RI White, Nicholas/I-4629-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1249 BP 371 EP 372 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701616 ER PT J AU Pybus, BS Sousa, J Jin, XN Carroll, D Luong, T Barnhart, R Reese, N Collazo, V Lanteri, C Wei, H Kozar, MP Melendez, V AF Pybus, Brandon S. Sousa, Jason Jin, Xiannu Carroll, Dustin Luong, ThuLan Barnhart, Rebecca Reese, NeCole Collazo, Vanessa Lanteri, Charlotte Wei, Hans Kozar, Michael P. Melendez, Victor TI INVESTIGATING THE RELATIONSHIP BETWEEN PRIMAQUINE HEMOTOXICITY AND ANTI-MALARIAL EFFICACY THROUGH METABOLIC PROFILING I: METABOLITE IDENTIFICATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Pybus, Brandon S.; Sousa, Jason; Jin, Xiannu; Carroll, Dustin; Luong, ThuLan; Barnhart, Rebecca; Reese, NeCole; Collazo, Vanessa; Lanteri, Charlotte; Wei, Hans; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1252 BP 372 EP 373 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701618 ER PT J AU Jin, XN Pybus, BS Sousa, J Carroll, D Luong, T Barnhart, R Reese, N Collazo, V Kozar, MP Melendez, V AF Jin, Xiannu Pybus, Brandon S. Sousa, Jason Carroll, Dustin Luong, ThuLan Barnhart, Rebecca Reese, NeCole Collazo, Vanessa Kozar, Michael P. Melendez, Victor TI INVESTIGATING THE RELATIONSHIP BETWEEN PRIMAQUINE HEMOTOXICITY AND ANTI-MALARIAL EFFICACY THROUGH METABOLIC PROFILING II: ENZYME PHENOTYPING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Jin, Xiannu; Pybus, Brandon S.; Sousa, Jason; Carroll, Dustin; Luong, ThuLan; Barnhart, Rebecca; Reese, NeCole; Collazo, Vanessa; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1253 BP 373 EP 373 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701620 ER PT J AU Tyner, SD Saunders, DL Yingyuen, K Chaichana, P Teja-Isavadharm, P Khemawoot, P Darapiseth, S Gosi, P Bethell, DB Se, Y Buathong, N Kuntawunginn, W Walsh, DS Socheat, D Lon, C Fukuda, MM AF Tyner, Stuart D. Saunders, David L. Yingyuen, Kritsanai Chaichana, Panjaporn Teja-isavadharm, Paktiya Khemawoot, Phisit Darapiseth, Sea Gosi, Panita Bethell, Delia B. Se, Youry Buathong, Nillawan Kuntawunginn, Worachet Walsh, Douglas S. Socheat, Duong Lon, Chanthap Fukuda, Mark M. TI A COMPARISON OF IN VITRO AND MOLECULAR MARKERS OF ANTIMALARIAL DRUG RESISTANCE IN NORTHERN AND WESTERN CAMBODIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Tyner, Stuart D.; Saunders, David L.; Yingyuen, Kritsanai; Chaichana, Panjaporn; Teja-isavadharm, Paktiya; Khemawoot, Phisit; Gosi, Panita; Bethell, Delia B.; Se, Youry; Buathong, Nillawan; Kuntawunginn, Worachet; Walsh, Douglas S.; Lon, Chanthap] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Darapiseth, Sea; Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Fukuda, Mark M.] USAF, Hlth Surveillance Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1273 BP 379 EP 379 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701640 ER PT J AU Lyke, KE Wang, A Dabo, A Arama, C Daou, M Diarra, I Dutta, S Angov, E Lanar, DE Plowe, CV Doumbo, OK Sztein, MB AF Lyke, Kirsten E. Wang, Amy Dabo, Abdoulaye Arama, Charles Daou, Modibo Diarra, Issa Dutta, Sheetij Angov, Evelina Lanar, David E. Plowe, Christopher V. Doumbo, Ogobara K. Sztein, Marcelo B. TI ANTIGEN-SPECIFIC B MEMORY CELL RESPONSES TO PLASMODIUM FALCIPARUM BLOOD STAGE MALARIA ANTIGENS AND SCHISTOSOMAL ANTIGENS IN MALIAN CHILDREN WITH AND WITHOUT SCHISTOSOMA HAEMATOBIUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH) CY NOV 03-07, 2010 CL Atlanta, GA SP Amer Soc Trop Med & Hyg (ASTMH) C1 [Lyke, Kirsten E.; Wang, Amy; Sztein, Marcelo B.] Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Dabo, Abdoulaye; Daou, Modibo; Diarra, Issa; Doumbo, Ogobara K.] Univ Bamako, Bamako, Mali. [Arama, Charles] Univ Stockholm, Stockholm, Sweden. [Dutta, Sheetij; Angov, Evelina; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Plowe, Christopher V.] Univ Maryland, Ctr Vaccine Dev, Howard Hughes Med Inst, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 SU S MA 1288 BP 383 EP 383 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 832QF UT WOS:000295819701655 ER PT J AU Wortmann, G Zapor, M Ressner, R Fraser, S Hartzell, J Pierson, J Weintrob, A Magill, A AF Wortmann, Glenn Zapor, Michael Ressner, Roseanne Fraser, Susan Hartzell, Josh Pierson, Joseph Weintrob, Amy Magill, Alan TI Lipsosomal Amphotericin B for Treatment of Cutaneous Leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SODIUM STIBOGLUCONATE; BRAZILIENSIS; INFECTION; EFFICACY AB Treatment options for cutaneous leishmaniasis in the United States are problematic because the available products are either investigational, toxic, and/or of questionable effectiveness A retrospective review of patients receiving liposomal amphotericin B through the Walter Reed Army Medical Center for the treatment of cutaneous leishmaniasis during 2007-2009 was conducted Twenty patients who acquired disease in five countries and with five different strains of Leishmania were treated, of whom 19 received a full course of treatment Sixteen (84%) of 19 experienced a cure with the initial treatment regimen Three patients did not fully heal after an initial treatment course, but were cured with additional dosing Acute infusion related reactions occurred in 25% and mild renal toxicity occurred in 45% of patients Although the optimum dosing regimen is undefined and the cost and toxicity may limit widespread use, liposomal amphotericin B is a viable treatment alternative for cutaneous leishmaniasis C1 [Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Clin, Infect Dis Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Infect Dis Clin Res Program, Bethesda, MD USA. [Pierson, Joseph] Guthrie Army Hlth Clin, Ft Drum, NY USA. [Magill, Alan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, Infect Dis Clin, Infect Dis Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 27 TC 45 Z9 48 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 BP 1028 EP 1033 DI 10.4269/ajtmh.2010.10.0171 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 679TV UT WOS:000284184600014 PM 21036832 ER PT J AU Tang, YX Rodpradit, P Chinnawirotpisan, P Mammen, MP Li, T Lynch, JA Putnak, R Zhang, CL AF Tang, Yuxin Rodpradit, Prinyada Chinnawirotpisan, Piyawan Mammen, Mammen P., Jr. Li, Tao Lynch, Julia A. Putnak, Robert Zhang, Chunlin TI Comparative Analysis of Full-Length Genomic Sequences of 10 Dengue Serotype 1 Viruses Associated with Different Genotypes, Epidemics, and Disease Severity Isolated in Thailand over 22 Years SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NUCLEAR RIBONUCLEOPROTEIN-K; NONSTRUCTURAL PROTEIN NS2A; CORE PROTEIN; ENVELOPE PROTEIN; AMINO-ACIDS; ENCEPHALITIS-VIRUS; HEMORRHAGIC-FEVER; CRYSTAL-STRUCTURE; SERINE-PROTEASE; RNA HELICASE AB Comparative sequence analysis was performed on the full-length genomic sequences of 10 representative dengue virus serotype 1 (DENV-1) strains sampled from patients at Children s Hospital Bangkok, Thailand over a 22 year period, which represented different epidemics, disease severity and sampling time The results showed remarkable inter genotypic variation between predominant and non predominant genotypes and genotype specific amino acids and nucleotides throughout the entire viral genome except for the 5'-non translated region The frequency of ultra genotypic variation was correlated with dengue transmission rate and sampling time The 5' non translated region of all 10 viruses was highly conserved for predominant and non predominant genotypes and NS2B was the most conserved protein Some intra genotypic substitutions of amino acids and nucleotides in predominant genotype strains were fixed in the viral genome since 1994, which indicated that the evolution of predominant genotype strains in situ over time might contribute to increased virus fitness important for sustaining dengue epidemics in Thailand C1 [Tang, Yuxin; Li, Tao; Lynch, Julia A.; Putnak, Robert; Zhang, Chunlin] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Rodpradit, Prinyada; Chinnawirotpisan, Piyawan; Mammen, Mammen P., Jr.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave Room A12, Silver Spring, MD 20910 USA. FU U S Department of Defense Fort Detrick Maryland FX This study was supported by the US Military Infectious Diseases Research Program of the U S Department of Defense Fort Detrick Maryland NR 63 TC 6 Z9 6 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2010 VL 83 IS 5 BP 1156 EP 1165 DI 10.4269/ajtmh.2010.10.0052 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 679TV UT WOS:000284184600037 PM 21036855 ER PT J AU Blacker, SN Brown, CQ Tarant, NS AF Blacker, Samuel N. Brown, Carlton Q. Tarant, Nicki S. TI Autonomic Dysreflexia-Like Syndrome in a T12 Paraplegic During Thoracic Spine Surgery SO ANESTHESIA AND ANALGESIA LA English DT Article ID CORD-INJURY; HYPERREFLEXIA; HYPERTENSION; ANESTHESIA; RESPONSES; RATS AB A 19-year-old African American man with a T12 spinal cord lesion underwent a T4-L5 thoracolumbar spinal fusion. Intraoperatively, his arterial blood pressure acutely increased from 110/60 to 260/130 mm Hg without a change in heart rate. The patient did not have pheochromocytoma, carcinoid syndrome, or thyroid storm. This presentation differs from autonomic dysreflexia because the spinal cord lesion was well below T6, hypertension was elicited with somatic stimulation above the lesion, and the response required aggressive pharmacologic management. This presentation is consistent with similar cases that support a central autonomic process. (Anesth Analg 2010;111:1290-2) C1 [Blacker, Samuel N.; Tarant, Nicki S.] Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. [Blacker, Samuel N.; Brown, Carlton Q.; Tarant, Nicki S.] Natl Naval Med Ctr, Dept Anesthesiol, Bethesda, MD USA. RP Blacker, SN (reprint author), Walter Reed Army Med Ctr, Dept Anesthesiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Samuel.Blacker@gmail.com NR 20 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 2010 VL 111 IS 5 BP 1290 EP 1292 DI 10.1213/ANE.0b013e3181f334b8 PG 3 WC Anesthesiology SC Anesthesiology GA 673PI UT WOS:000283675000032 PM 20829560 ER PT J AU Cairns, CB Maier, RV Adeoye, O Baptiste, D Barsan, WG Blackbourne, L Burd, R Carpenter, C Chang, D Cioffi, W Cornwell, E Dean, M Dyer, C Jaffe, D Manley, G Meurer, WJ Neumar, R Silbergleit, R Stevens, M Wang, M Weiner, D Wright, D AF Cairns, Charles B. Maier, Ronald V. Adeoye, Opeolu Baptiste, Darryl Barsan, William G. Blackbourne, Lorne Burd, Randall Carpenter, Christopher Chang, David Cioffi, William Cornwell, Edward Dean, Michael Dyer, Carmel Jaffe, David Manley, Geoff Meurer, William J. Neumar, Robert Silbergleit, Robert Stevens, Molly Wang, Michael Weiner, Debra Wright, David CA Roundtable External Participants Roundtable Steering Comm Fed Participants TI NIH Roundtable on Emergency Trauma Research SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID INFRASTRUCTURE AB Study objective: The National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009. The objectives of the roundtable are to identify key research questions essential to advancing the scientific underpinnings of emergency trauma care and to discuss the barriers and best means to advance research by exploring the role of trauma research networks and collaboration between NIH and the emergency trauma care community. Methods: Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. During and after the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency trauma care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype of patients on the time spectrum of acuity and severity after injury and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency trauma research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical injuries, and the development of treatments capable of halting or reversing them; the need for novel experimental models of acute injury; the need to assess the effect of development and aging on the postinjury response; and the need to understand why there are regional differences in outcomes after injury. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. Conclusion: The science of emergency trauma care may be advanced by facilitating the following: (1) development of an acute injury template for clinical research; (2) developing emergency trauma clinical research networks; (3) integrating emergency trauma research into Clinical and Translational Science Awards; (4) developing emergency care specific initiatives within the existing structure of NIH institutes and centers; (5) involving acute trauma and emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; (7) performing research to address ethical and regulatory issues; and (8) training emergency care investigators with research training programs. [Ann Emerg Med. 2010;56:538-550.] C1 [Cairns, Charles B.] Univ N Carolina, Dept Emergency Med, Chapel Hill, NC 27599 USA. [Maier, Ronald V.] Univ Washington, Harborview Med Ctr, Seattle, WA 98195 USA. [Adeoye, Opeolu] Univ Cincinnati, Cincinnati, OH 45221 USA. [Baptiste, Darryl] Toronto Western Hosp, Toronto, ON, Canada. [Barsan, William G.; Meurer, William J.; Silbergleit, Robert] Univ Michigan, Ann Arbor, MI 48109 USA. [Blackbourne, Lorne] USA, Inst Surg Res, Washington, DC USA. [Burd, Randall] Childrens Natl Med Ctr, Washington, DC USA. [Carpenter, Christopher; Jaffe, David] Washington Univ, St Louis, MO 63130 USA. [Chang, David] Johns Hopkins Univ, Baltimore, MD 21218 USA. [Chang, David; Cornwell, Edward] Howard Univ, Washington, DC USA. [Cioffi, William] Rhode Isl Hosp, Providence, RI 02903 USA. [Dean, Michael] Univ Utah, Salt Lake City, UT 84112 USA. [Dyer, Carmel] Univ Texas Houston, Houston, TX USA. [Manley, Geoff] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Neumar, Robert] Univ Penn, Philadelphia, PA 19104 USA. [Stevens, Molly] Med Coll Wisconsin, Milwaukee, WI USA. [Wang, Michael] Univ Miami, Coral Gables, FL 33124 USA. [Weiner, Debra] Childrens Hosp Boston, Boston, MA USA. [Wright, David] Emory Univ, Atlanta, GA 30322 USA. RP Cairns, CB (reprint author), Univ N Carolina, Dept Emergency Med, 170 Manning Dr, Chapel Hill, NC 27599 USA. EM ccairns@med.unc.edu; ronmaier@u.washington.edu; opeolu.adeoye@uc.edu; darryl.bapiste@uhnresearch.ca; Wbarsan@umich.edu; lorne.blackbourne@amedd.army.mil; rburd@cnmc.org; carpenterc@msnotes.wustl.edu; dchang1@jhmi.edu; wcioffi@lifespan.org; ecornwell@howard.edu; mike.dean@hsc.utah.edu; carmel.b.dyer@uth.tmc.edu; jaffe@kids.wustl.edu; manleyg@neurosurg.ucsf.edu; wmeurer@umich.edu; Robert.Neumar@uphs.upenn.edu; robie@med.umich.edu; mstevens@mcw.edu; MWang2@med.miami.edu; debra.weiner@childrens.harvard.edu; david.wright@emory.edu RI Carpenter, Christopher/E-3720-2013; Wright, David/F-1209-2013; OI Carpenter, Christopher/0000-0002-2603-7157; Wright, David/0000-0002-7145-9105; Kleitman, Naomi/0000-0003-1089-0257; Guerrero, Giovanna/0000-0003-4931-8530; Kopp, Jeffrey/0000-0001-9052-186X FU NIH FX By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. Funding for the Roundtable on Emergency Trauma Research was provided by the NIH. NR 18 TC 18 Z9 18 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD NOV PY 2010 VL 56 IS 5 BP 538 EP 550 DI 10.1016/j.annemergmed.2010.05.029 PG 13 WC Emergency Medicine SC Emergency Medicine GA 681DY UT WOS:000284292800019 PM 21036294 ER PT J AU Riser, MS Bland, CM Rudisill, CN Bookstaver, PB AF Riser, M. Shawn Bland, Christopher M. Rudisill, Celeste N. Bookstaver, P. Brandon TI Cerebrospinal Fluid Penetration of High-Dose Daptomycin in Suspected Staphylococcus aureus Meningitis SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE bacteremia; daptomycin; meningitis; Staphylococcus aureus ID IN-VITRO; PNEUMOCOCCAL MENINGITIS; BACTERIAL-MENINGITIS; CEFTRIAXONE; VIVO; ENDOCARDITIS; ANTIBIOTICS; VANCOMYCIN; MORTALITY; RESISTANT AB OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations. CASE SUMMARY: A 54-year-old male presented to the emergency department with generalized weakness and presumed health-care associated pneumonia shown on chest radiograph. Treatment was empirically initiated with vancomycin, levofloxacin, and piperacillin/tazobactam. Blood cultures revealed S. aureus susceptible to oxacillin. Empiric antibiotic treatment was narrowed to nafcillin on day 4. On day 8, the patient developed acute renal failure (serum creatinine 1.9 mg/dL, increased from 1.2 mg/dL the previous day and 0.8 mg/dL on admission). The patient's Glasgow Coma Score was 3, with normal findings shown on computed tomography scan of the head 72 hours following an episode of cardiac arrest on day 10. The patient experienced relapsing MSSA bacteremia on day 9, increasing the suspicion for a central nervous system (CNS) infection. Nafcillin was discontinued and daptomycin 9 mg/kg daily was initiated for suspected meningitis and was continued until the patient's death on day 16. Daptomycin serum and CSF trough concentrations were 11.21 mu g/mL and 0.52 mu g/mL, respectively, prior to the third dose. Lumbar puncture results were inconclusive and no further blood cultures were positive for MSSA. Creatine kinase levels were normal prior to daptomycin therapy and were not reassessed. DISCUSSION: Daptomycin was initiated in our patient secondary to possible nafcillin-induced acute interstitial nephritis and relapsing bacteremia. At a dose of 9 mg/kg, resultant penetration of 5% was higher than in previous reports, more consistent with inflamed meninges. CONCLUSIONS: High-dose daptomycin may be an alternative option for MSSA bacteremia with or without a CNS source in patients who have failed or cannot tolerate standard therapy. Further clinical evaluation in patients with confirmed meningitis is warranted. C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Riser, M. Shawn; Rudisill, Celeste N.; Bookstaver, P. Brandon] Univ S Carolina Campus, S Carolina Coll Pharm, Columbia, SC USA. RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. EM chris.bland@us.army.mil FU Cubist Pharmaceuticals; Merck Co. Inc.; Astellas US Pharma FX Dr. Bland is a member of the speaker's bureau for Cubist Pharmaceuticals. Dr. Bookstaver has received research funding from Cubist Pharmaceuticals, Merck & Co. Inc., and Astellas US Pharma. NR 20 TC 11 Z9 11 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD NOV PY 2010 VL 44 IS 11 BP 1832 EP 1835 DI 10.1345/aph.1P307 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 679XX UT WOS:000284195200020 PM 20959502 ER PT J AU Summers, TA Moncur, JT AF Summers, Thomas A., Jr. Moncur, Joel T. TI The Small Cell Variant of Anaplastic Large Cell Lymphoma SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Review ID NON-HODGKINS-LYMPHOMA; STERNBERG-REED CELLS; OF-THE-LITERATURE; CLINICAL-FEATURES; CLINICOPATHOLOGICAL ENTITY; CHROMOSOMAL-ABNORMALITY; PERIPHERAL-BLOOD; LEUKEMIC PHASE; KI-1 LYMPHOMA; BONE-MARROW AB Anaplastic large cell lymphomas constitute a heterogeneous group of hematopoietic neoplasms that are characterized by immunopositivity for CD30 and the presence, in varying degrees, of large, pleomorphic "hallmark'' cells. Primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphomas are a subset of this group. Numerous heterogeneous histomorphologic patterns have been described in anaplastic lymphoma kinase-positive anaplastic large cell lymphomas, and all patterns tend to have a better prognosis than that found in anaplastic lymphoma kinase-negative cases. We provide a short review of the small cell variant of anaplastic large cell lymphoma to facilitate the diagnosis of this difficult-to-recognize entity, which may be confused with reactive processes, commonly presents with disseminated disease, and pursues an aggressive clinical course. (Arch Pathol Lab Med. 2010; 134: 1706-1710) C1 [Summers, Thomas A., Jr.; Moncur, Joel T.] Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, Washington, DC 20307 USA. RP Summers, TA (reprint author), Dept Anat Pathol, Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM thomas.a.summers@verizon.net NR 29 TC 3 Z9 4 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD NOV PY 2010 VL 134 IS 11 BP 1706 EP 1710 PG 5 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 678VI UT WOS:000284109800020 PM 21043827 ER PT J AU Thurmond, VA Hicks, R Gleason, T Miller, AC Szuflita, N Orman, J Schwab, K AF Thurmond, Veronica A. Hicks, Ramona Gleason, Theresa Miller, A. Cate Szuflita, Nicholas Orman, Jean Schwab, Karen TI Advancing Integrated Research in Psychological Health and Traumatic Brain Injury: Common Data Elements SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Analysis, demographics; Biomarkers; Brain injuries, traumatic; Outcome measures; Rehabilitation; Stress disorders, posttraumatic ID IRAQ AB In civilian, military, and veteran populations, there is increased recognition of the interrelationship between traumatic brain injury (TBI) and some psychological health (PH) disorders and the need to better understand the relationships by integrating research for these topics. The use of different measures to assess similar study variables and/or assess outcomes may limit important advances in PH and TBI research. Without a set of common data elements (CDEs; to include variable definitions and recommended measures for the purpose of this discussion), comparison of findings across studies is challenging. The federal agencies involved in PH and TBI research, the National Institute of Neurological Disorders and Stroke, Department of Veterans Affairs, National Institute on Disability and Rehabilitation Research, Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury, and Defense and Veterans Brain Injury Center, therefore cosponsored a scientific initiative to develop CDEs for PH and TBI research. Scientific experts were invited to participate in 1 of 8 working groups to develop recommendations for specific topic-driven CDEs. Draft recommendations were presented and discussed in the workshop "Advancing Integrated Research in Psychological Health and Traumatic Brain Injury: Common Data Elements (CDE)" held on March 23-24, 2009, in Silver Spring, MD. The overall process leading to the workshop and subsequent recommendations by the working groups are presented in this article. Topic-driven recommendations for CDEs are presented in individual reports in this edition. C1 [Hicks, Ramona] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. [Gleason, Theresa; Orman, Jean] Dept Vet Affairs, Washington, DC USA. [Miller, A. Cate] Natl Inst Disabil & Rehabil Res, US Dept Educ, Washington, DC USA. [Schwab, Karen] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Thurmond, Veronica A.; Szuflita, Nicholas] Def Ctr Excellence PH TBI, Silver Spring, MD 20910 USA. RP Thurmond, VA (reprint author), Def Ctr Excellence PH TBI, 1335 East West Highway, Silver Spring, MD 20910 USA. EM veronica.thurmond@us.anny.mil NR 7 TC 32 Z9 32 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1633 EP 1636 DI 10.1016/j.apmr.2010.06.034 PG 4 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400001 PM 21044705 ER PT J AU Maas, AI Harrison-Felix, CL Menon, D Adelson, PD Balkin, T Bullock, R Engel, DC Gordon, W Orman, JL Lew, HL Robertson, C Temkin, N Valadka, A Verfaellie, M Wainwright, M Wright, DW Schwab, K AF Maas, Andrew I. Harrison-Felix, Cynthia L. Menon, David Adelson, P. David Balkin, Tom Bullock, Ross Engel, Doortje C. Gordon, Wayne Orman, Jean Langlois Lew, Henry L. Robertson, Claudia Temkin, Nancy Valadka, Alex Verfaellie, Mieke Wainwright, Mark Wright, David W. Schwab, Karen TI Common Data Elements for Traumatic Brain Injury: Recommendations From the Interagency Working Group on Demographics and Clinical Assessment SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Clinical protocols; Clinical studies; Data collection; Forms and records control; Rehabilitation; Standardization; Traumatic brain injury ID PROGNOSTIC VALUE; INTRACRANIAL-PRESSURE; SECONDARY INSULTS; HEAD-INJURY; IMPACT; RACE; RACE/ETHNICITY; ETHNICITY; DESIGN; IRAQ AB Comparing results across studies in traumatic brain injury (TB!) has been difficult because of the variability in data coding, definitions, and collection procedures. The global aim of the Working Group on Demographics and Clinical Assessment was to develop recommendations on the coding of clinical and demographic variables for TBI studies applicable across the broad spectrum of TBI, and to classify these as core, supplemental, or emerging. The process was consensus driven, with input from experts over a broad range of disciplines. Special consideration was given to military and pediatric TBI. Categorizing clinical elements as core versus supplemental proved difficult, given the great variation in types of studies and their interests. The data elements are contained in modules, which are grouped together in categories. Three levels of detail for coding data elements were developed: basic, intermediate, and advanced, with the greatest level of detail in the advanced version. In every case, the more detailed coding can be collapsed into the basic version. Templates were produced to summarize coding formats, motivation of choices, and recommendations for procedures. Work is ongoing to include more international participation and to provide an electronic data entry format with pull-down menus and automated data checks. This proposed standardization will facilitate comparison of research findings across studies and encourage high-quality meta-analysis of individual patient data. C1 [Maas, Andrew I.] Univ Antwerp Hosp, Dept Neurosurg, B-2650 Edegem, Belgium. [Harrison-Felix, Cynthia L.] Craig Hosp, Englewood, CO USA. [Menon, David] Univ Cambridge, Cambridge, England. [Adelson, P. David] Phoenix Childrens Neurosci Inst, Phoenix, AZ USA. [Balkin, Tom] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Bullock, Ross] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Engel, Doortje C.] Univ Heidelberg Hosp, Heidelberg, Germany. [Gordon, Wayne] Mt Sinai Sch Med, New York, NY USA. [Orman, Jean Langlois] Rehabil Res & Dev Serv, Dept Vet Affairs, Washington, DC USA. [Lew, Henry L.] Virginia Commonwealth Univ, Sch Med, Def & Vet Brain Injury Ctr, Richmond, VA USA. [Lew, Henry L.] Virginia Commonwealth Univ, Sch Med, Dept Phys Med & Rehabil, Richmond, VA USA. [Robertson, Claudia] Baylor Coll Med, Houston, TX 77030 USA. [Temkin, Nancy] Univ Washington, Seattle, WA 98195 USA. [Valadka, Alex] Seton Brain & Spine Inst, Austin, TX USA. [Verfaellie, Mieke] Boston Univ, Sch Med, Boston, MA 02118 USA. [Verfaellie, Mieke] Boston VA Hlth Care Syst, Boston, MA USA. [Wainwright, Mark] Northwestern Univ, Chicago, IL 60611 USA. [Wright, David W.] Emory Univ, Sch Med, Atlanta, GA USA. [Schwab, Karen] Def & Vet Brain Injury Ctr, Washington, DC USA. RP Maas, AI (reprint author), Univ Antwerp Hosp, Dept Neurosurg, Wilrijkstr 10, B-2650 Edegem, Belgium. EM andrew.maas@uza.be RI Maas, Andrew/C-5584-2013; Wright, David/F-1209-2013; OI Maas, Andrew/0000-0003-1612-1264; Wright, David/0000-0002-7145-9105; Verfaellie, Mieke/0000-0001-5535-4584 FU National Institutes of Health-National Institute of Neurological Disorders and Stroke [NIH-NINDS] [NS 042691]; National Institute on Disability and Rehabilitation Research; Department of Veterans Affairs; Defense and Veterans Brain Injury Center; Defense Centers of Excellence FX Support for the meetings and activities of the Working Group on Demographics and Clinical Assessment was funded in the context of the interagency initiative toward "an integrated approach to Research in Psychological Health and Traumatic Brain Injury" (National Institutes of Health-National Institute of Neurological Disorders and Stroke [NIH-NINDS]; the National Institute on Disability and Rehabilitation Research; the Department of Veterans Affairs; the Defense and Veterans Brain Injury Center and the Defense Centers of Excellence). The development of CDEs was further supported by a supplemental grant from NIH-NINDS (grant no. NS 042691). NR 33 TC 35 Z9 35 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1641 EP 1649 DI 10.1016/j.apmr.2010.07.232 PG 9 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400003 PM 21044707 ER PT J AU Wilde, EA Whiteneck, GG Bogner, J Bushnik, T Cifu, DX Dikmen, S French, L Giacino, JT Hart, T Malec, JF Millis, SR Novack, TA Sherer, M Tulsky, DS Vanderploeg, RD von Steinbuechel, N AF Wilde, Elisabeth A. Whiteneck, Gale G. Bogner, Jennifer Bushnik, Tamara Cifu, David X. Dikmen, Sureyya French, Louis Giacino, Joseph T. Hart, Tessa Malec, James F. Millis, Scott R. Novack, Thomas A. Sherer, Mark Tulsky, David S. Vanderploeg, Rodney D. von Steinbuechel, Nicole TI Recommendations for the Use of Common Outcome Measures in Traumatic Brain Injury Research SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Outcome assessment; health care; Brain injuries; Neurobehavioral manifestations; Research; Rehabilitation ID QUALITY-OF-LIFE; PORTLAND ADAPTABILITY INVENTORY; POST-CONCUSSION SYMPTOMS; FAMILY ASSESSMENT DEVICE; BEHAVIOR SCALE FRSBE; MINOR HEAD-INJURY; NOS-TBI; POSTCONCUSSION SYNDROME; ALCOHOL-CONSUMPTION; SIGNIFICANT OTHERS AB This article summarizes the selection of outcome measures by the interagency Traumatic Brain Injury (TBI) Outcomes Workgroup to address primary clinical research objectives, including documentation of the natural course of recovery from TBI, prediction of later outcome, measurement of treatment effects, and comparison of outcomes across studies. Consistent with other Common Data Elements Workgroups, the TBI Outcomes Workgroup adopted the standard 3-tier system in its selection of measures. In the first tier, core measures included valid, robust, and widely applicable outcome measures with proven utility in TBI from each identified domain, including global level of function, neuropsychological impairment, psychological status, TBI-related symptoms, executive functions, cognitive and physical activity limitations, social role participation, and perceived health-related quality of life. In the second tier, supplemental measures were recommended for consideration in TBI research focusing on specific topics or populations. In the third tier, emerging measures included important instruments currently under development, in the process of validation, or nearing the point of published findings that have significant potential to be superior to some older ("legacy") measures in the core and supplemental lists and may eventually replace them as evidence for their utility emerges. C1 [Wilde, Elisabeth A.; Sherer, Mark] Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA. [Wilde, Elisabeth A.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA. [Wilde, Elisabeth A.] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA. [Sherer, Mark] TIRR Mem Hermann, Houston, TX USA. [Wilde, Elisabeth A.] Michael E DeBakey Vet Adm Med Ctr, Houston, TX USA. [Sherer, Mark] Univ Texas Med Sch Houston, Houston, TX USA. [Whiteneck, Gale G.] Craig Hosp, Englewood, CO USA. [Bogner, Jennifer] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA. [Bushnik, Tamara] Rusk Inst Rehabil, Dept Rehabil Med, New York, NY USA. [Cifu, David X.] Virginia Commonwealth Univ, Dept Phys Med & Rehabil, PM&R Serv, Hunter Holmes McGuire Vet Adm Med Ctr, Richmond, VA USA. [Dikmen, Sureyya] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [French, Louis] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Giacino, Joseph T.] JFK Johnson Rehabil Inst, Edison, NJ USA. [Giacino, Joseph T.] Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Boston, MA USA. [Hart, Tessa] Moss Rehabil Res Inst, Elkins Pk, PA USA. [Malec, James F.] Indiana Univ Sch Med, Dept Phys Med & Rehabil, Indianapolis, IN USA. [Malec, James F.] Rehabil Hosp Indiana, Indianapolis, IN USA. [Millis, Scott R.] Wayne State Univ, Sch Med, Dept Phys Med & Rehabil, Detroit, MI USA. [Millis, Scott R.] Wayne State Univ, Sch Med, Dept Emergency Med, Detroit, MI USA. [Novack, Thomas A.] Univ Alabama Birmingham, Dept Phys Med & Rehabil, Birmingham, AL USA. [Tulsky, David S.] Univ Michigan, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. [Vanderploeg, Rodney D.] James A Haley Vet Hosp, Psychol Serv, Tampa, FL 33612 USA. [Vanderploeg, Rodney D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Vanderploeg, Rodney D.] Univ S Florida, Dept Psychiat, Tampa, FL USA. [von Steinbuechel, Nicole] Univ Gottingen, Dept Med Psychol & Med Sociol, Univ Med Ctr, Gottingen, Germany. RP Wilde, EA (reprint author), Baylor Coll Med, Dept Phys Med & Rehabil, 1709 Dryden Rd,Ste 1200, Houston, TX 77030 USA. EM ewilde@bcm.edu OI Bushnik, Tamara/0000-0003-3328-257X FU National Institutes of Health (NIH: National Institute of Neurological Disorders and Stroke); U.S. Department of Veterans Affairs (VA); U.S. Department of Defense (DoD); U.S. Department of Education/National Institute on Disability and Rehabilitation Research FX Supported by the National Institutes of Health (NIH: National Institute of Neurological Disorders and Stroke), U.S. Department of Veterans Affairs (VA), U.S. Department of Defense (DoD), and U.S. Department of Education/National Institute on Disability and Rehabilitation Research. NR 101 TC 119 Z9 121 U1 8 U2 29 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1650 EP 1660 DI 10.1016/j.apmr.2010.06.033 PG 11 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400004 PM 21044708 ER PT J AU Duhaime, AC Gean, AD Haacke, EM Hicks, R Wintermark, M Mukherjee, P Brody, D Latour, L Riedy, G AF Duhaime, Ann-Christine Gean, Alisa D. Haacke, E. Mark Hicks, Ramona Wintermark, Max Mukherjee, Pratik Brody, David Latour, Lawrence Riedy, Gerard CA Common Data Elements Neuroimaging Pediat Working Grp Members TI Common Data Elements in Radiologic Imaging of Traumatic Brain Injury SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Clinical research; Clinical trials; Database; Head injury; Magnetic resonance imaging; Radiology; Rehabilitation; Traumatic brain injury ID DIFFUSE AXONAL INJURY; HEAD-INJURY; CLASSIFICATION; MICROBLEEDS; CHILDREN; VOLUME; MILD AB Radio logic brain imaging is the most useful means of visualizing and categorizing the location, nature, and degree of damage to the central nervous system sustained by patients with traumatic brain injury (TBI). In addition to determining acute patient management and prognosis, imaging is crucial for the characterization and classification of injuries for natural history studies and clinical trials. This article is the initial result of a workshop convened by multiple national health care agencies in March 2009 to begin to make recommendations for potential data elements dealing with specific radiologic features and definitions needed to characterize injuries, as well as specific techniques and parameters needed to optimize radiologic data acquisition. The neuroimaging work group included professionals with expertise in basic imaging research and physics, clinical neuroradiology, neurosurgery, neurology, physiatry, psychiatry, TBI research, and research database formation. This article outlines the rationale and overview of their specific recommendations. In addition, we review the contributions of various imaging modalities to the understanding of TBI and the general principles needed for database flexibility and evolution over time to accommodate technical advances. C1 [Duhaime, Ann-Christine] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Gean, Alisa D.] San Francisco Gen Hosp, Dept Radiol, Brain & Spinal Cord Injury Ctr, San Francisco, CA 94110 USA. [Haacke, E. Mark] Wayne State Univ, Dept Biomed Engn, Detroit, MI USA. [Hicks, Ramona] NIH, Repair & Plast Program, Bethesda, MD 20892 USA. [Wintermark, Max; Mukherjee, Pratik] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA. [Mukherjee, Pratik] Univ Calif San Francisco, Dept Bioengn, San Francisco, CA 94143 USA. [Brody, David] Washington Univ, Dept Neurol, St Louis, MO USA. [Latour, Lawrence] Natl Inst Neurol Disorders & Stroke, Stroke Diagnost & Therapeut Sect, Stroke Branch, Bethesda, MD USA. [Riedy, Gerard] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Duhaime, AC (reprint author), Massachusetts Gen Hosp, Wang 331,115 Parkman St, Boston, MA 02114 USA. EM aduhaime@partners.org RI Mukherjee, Pratik/A-5446-2008; OI Mukherjee, Pratik/0000-0001-7473-7409; Wintermark, Max/0000-0002-6726-3951 NR 18 TC 42 Z9 42 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1661 EP 1666 DI 10.1016/j.apmr.2010.07.238 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400005 PM 21044709 ER PT J AU Manley, GT Diaz-Arrastia, R Brophy, M Engel, D Goodman, C Gwinn, K Veenstra, TD Ling, G Ottens, AK Tortella, F Hayes, RL AF Manley, Geoffrey T. Diaz-Arrastia, Ramon Brophy, Mary Engel, Doortje Goodman, Clay Gwinn, Katrina Veenstra, Timothy D. Ling, Geoffrey Ottens, Andrew K. Tortella, Frank Hayes, Ronald L. TI Common Data Elements for Traumatic Brain Injury: Recommendations From the Biospecimens and Biomarkers Working Group SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Biological Markers; Brain Injuries; Rehabilitation ID HUMAN CEREBROSPINAL-FLUID; PROTEOMIC ANALYSIS; GENOTYPE; STANDARDIZATION; POLYMORPHISM; ASSOCIATION; PROTEINS; EVENTS; APOE; CSF AB Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI. C1 [Manley, Geoffrey T.] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94110 USA. [Diaz-Arrastia, Ramon] Univ Texas SW Med Sch, Dallas, TX USA. [Brophy, Mary] Dept Vet Affairs Cooperat Studies Program, Boston, MA USA. [Engel, Doortje] Univ Heidelberg Hosp, Heidelberg, Germany. [Goodman, Clay; Gwinn, Katrina] Baylor Coll Med, Houston, TX 77030 USA. [Veenstra, Timothy D.] NCI, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21701 USA. [Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Alachua, FL USA. RP Manley, GT (reprint author), Univ Calif San Francisco, Dept Neurosurg, 1001 Potrero Ave,Bldg 1,Room 101, San Francisco, CA 94110 USA. EM manleyg@neurosurg.ucsf.edu RI Ottens, Andrew/K-3352-2012; OI Gwinn, Katrina/0000-0002-8277-651X NR 31 TC 36 Z9 36 U1 2 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1667 EP 1672 DI 10.1016/j.apmr.2010.05.018 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400006 PM 21044710 ER PT J AU Kaloupek, DG Chard, KM Freed, MC Peterson, AL Riggs, DS Stein, MB Tuma, F AF Kaloupek, Danny G. Chard, Kathleen M. Freed, Michael C. Peterson, Alan L. Riggs, David S. Stein, Murray B. Tuma, Farris TI Common Data Elements for Posttraumatic Stress Disorder Research SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Diagnostic techniques and procedures; Outcome assessment; Rehabilitation; Stress disorders, post-traumatic ID TRAUMATIC BRAIN-INJURY; LIFE EVENTS QUESTIONNAIRE; INTERAGENCY WORKING GROUP; PREFERENCE-BASED MEASURE; ADMINISTERED PTSD SCALE; MENTAL-HEALTH PROBLEMS; PSYCHOMETRIC PROPERTIES; MILITARY SERVICE; RISK-FACTORS; DSM-IV AB An expert work group with 7 members was formed under the cosponsorship of 5 U.S. federal agencies to identify common data elements for research related to posttraumatic stress disorder (PTSD). The work group reviewed both previous and contemporary measurement standardization efforts for PTSD research and engaged in a series of electronic and live discussions to address a set of predefined aims. Eight construct domains relevant to PTSD were identified: (1) traditional demographics, (2) exposure to stressors and trauma, (3) potential stress moderators, (4) trauma assessment, (5) PTSD screening, (6) PTSD symptoms and diagnosis, (7) PTSD-related functioning and disability, and (8) mental health history. Measures assigned to the core data elements category have relatively low time-and-effort costs in order to make them potentially applicable across a wide range of studies for which PTSD is a relevant condition. Measures assigned to the supplemental data elements category have greater costs but generally demonstrate stronger psychometric performance and provide more extensive information. Accordingly, measures designated as supplemental are recommended instead of or in addition to corresponding core measures whenever resources and study design allow. The work group offered 4 caveats that highlight potential limitations and emphasize the voluntary nature of standardization for PTSD-related measurement. C1 [Kaloupek, Danny G.] Boston Univ, Sch Med, Vet Affairs Boston Healthcare Syst, Vet Affairs Natl Ctr Posttraumat Stress Disorder, Boston, MA 02118 USA. [Kaloupek, Danny G.] Boston Univ, Sch Med, Div Psychiat, Boston, MA 02118 USA. [Chard, Kathleen M.] Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA. [Chard, Kathleen M.] Univ Cincinnati, Cincinnati Vet Affairs Med Ctr, Cincinnati, OH USA. [Freed, Michael C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Freed, Michael C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Freed, Michael C.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Riggs, David S.] Uniformed Serv Univ Hlth Sci, Ctr Deployment Psychol, Bethesda, MD 20814 USA. [Peterson, Alan L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Tuma, Farris] NIMH, Div Adult Translat Res & Treatment Dev, Bethesda, MD 20892 USA. RP Kaloupek, DG (reprint author), VA Boston Healthcare Syst, Natl Ctr PTSD 116B 2, 150 S Huntington Ave, Boston, MA 02130 USA. EM danny.kaloupek@va.gov OI Kaloupek, Danny/0000-0002-0795-593X NR 69 TC 17 Z9 17 U1 4 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2010 VL 91 IS 11 BP 1684 EP 1691 DI 10.1016/j.apmr.2010.06.032 PG 8 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 681UQ UT WOS:000284346400008 PM 21044712 ER PT J AU Ellsworth, DL Decewicz, DJ Neatrour, DM Burke, A Haberkorn, MJ Patney, HL Vernalis, MN AF Ellsworth, Darrell L. Decewicz, David J. Neatrour, David M. Burke, Amy Haberkorn, Mary Jane Patney, Heather L. Vernalis, Marina N. TI Intensive Lifestyle Modification for CAD Reversal Successfully Reduces Circulating Levels of Metabolic Hormones Insulin and Leptin SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY LA English DT Meeting Abstract CT Scientific Sessions on Arteriosclerosis, Thrombosis and Vascular Biology CY APR 08-10, 2010 CL San Francisco, CA C1 [Ellsworth, Darrell L.; Decewicz, David J.; Patney, Heather L.] Windber Rsch Inst, Windber, PA USA. [Neatrour, David M.; Burke, Amy; Haberkorn, Mary Jane] Windber Med Cntr, Windber, PA USA. [Vernalis, Marina N.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-5642 J9 ARTERIOSCL THROM VAS JI Arterioscler. Thromb. Vasc. Biol. PD NOV PY 2010 VL 30 IS 11 BP E245 EP E245 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 667YS UT WOS:000283234800286 ER PT J AU Deane, KD O'Donnell, CI Hueber, W Majka, DS Lazar, AA Derber, LA Gilliland, WR Edison, JD Norris, JM Robinson, WH Holers, VM AF Deane, Kevin D. O'Donnell, Colin I. Hueber, Wolfgang Majka, Darcy S. Lazar, Ann A. Derber, Lezlie A. Gilliland, William R. Edison, Jess D. Norris, Jill M. Robinson, William H. Holers, V. Michael TI The Number of Elevated Cytokines and Chemokines in Preclinical Seropositive Rheumatoid Arthritis Predicts Time to Diagnosis in an Age-Dependent Manner SO ARTHRITIS AND RHEUMATISM LA English DT Article ID CYCLIC CITRULLINATED PEPTIDE; C-REACTIVE PROTEIN; UP-REGULATION; BLOOD-DONORS; 1ST-DEGREE RELATIVES; PROSPECTIVE COHORT; EFFECTS MODELS; ANTIBODIES; ONSET; AUTOANTIBODIES AB Objective. To evaluate levels of biomarkers in preclinical rheumatoid arthritis (RA) and to use elevated biomarkers to develop a model for the prediction of time to future diagnosis of seropositive RA. Methods. Stored samples obtained from 73 military cases with seropositive RA prior to RA diagnosis and from controls (mean 2.9 samples per case; samples collected a mean of 6.6 years prior to diagnosis) were tested for rheumatoid factor (RF) isotypes, anti-cyclic citrullinated peptide (anti-CCP) antibodies, 14 cytokines and chemokines (by bead-based assay), and C-reactive protein (CRP). Results. Preclinical positivity for anti-CCP and/or >= 2 RF isotypes was >96% specific for future RA. In preclinical RA, levels of the following were positive in a significantly greater proportion of RA cases versus controls: interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-10, IL-12p40, IL-12p70, IL-15, fibroblast growth factor 2, flt-3 ligand, tumor necrosis factor alpha, interferon-gamma-inducible 10-kd protein, granulocyte-macrophage colony-stimulating factor, and CRP. Also, increasing numbers of elevated cytokines/chemokines were present in cases nearer to the time of diagnosis. RA patients who were >= 40 years old at diagnosis had a higher proportion of samples positive for cytokines/chemokines 5-10 years prior to diagnosis than did patients who were <40 years old at diagnosis (P < 0.01). In regression modeling using only case samples positive for autoantibodies highly specific for future RA, increasing numbers of cytokines/chemokines were predictive of decreased time to diagnosis, and the predicted time to diagnosis based on cytokines/chemokines was longer in older compared with younger cases. Conclusion. Levels of autoantibodies, cytokines/chemokines, and CRP are elevated in the preclinical period of RA development. In preclinical autoantibody-positive cases, the number of elevated cytokines/chemokines is predictive of the time of diagnosis of future RA in an age-dependent manner. C1 [Deane, Kevin D.] Univ Colorado, Sch Med, Div Rheumatol, Aurora, CO 80045 USA. [O'Donnell, Colin I.; Norris, Jill M.] Colorado Sch Publ Hlth, Aurora, CO USA. [Hueber, Wolfgang; Robinson, William H.] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Hueber, Wolfgang; Robinson, William H.] Stanford Univ, Stanford, CA 94305 USA. [Hueber, Wolfgang] Novartis Inst BioMed Res, Basel, Switzerland. [Majka, Darcy S.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Lazar, Ann A.] Harvard Univ, Boston, MA 02115 USA. [Lazar, Ann A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Gilliland, William R.; Edison, Jess D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Deane, KD (reprint author), Univ Colorado, Sch Med, Div Rheumatol, 1775 Aurora Court,Mail Stop B-115, Aurora, CO 80045 USA. EM Kevin.Deane@UCDenver.edu FU NIH [AR-51394, AI-50864, AR-051461, T32-CA-09337, P30-DE-020752, AR-058713, AR-054822]; American College of Rheumatology Research and Education Foundation FX Drs. Deane, Norris, and Holers, Mr. O'Donnell, and Ms Derber's work was supported by NIH grants AR-51394, AI-50864, and AR-051461. Dr. Lazar's work was supported by NIH grants T32-CA-09337 and P30-DE-020752. Dr. Robinson's work was supported by NIH grants AR-058713 and AR-054822 and by the American College of Rheumatology Research and Education Foundation. NR 37 TC 81 Z9 85 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD NOV PY 2010 VL 62 IS 11 BP 3161 EP 3172 DI 10.1002/art.27638 PG 12 WC Rheumatology SC Rheumatology GA 674UU UT WOS:000283776400005 PM 20597112 ER PT J AU Waterman, SM Slade, D Masini, BD Owens, BD AF Waterman, Scott M. Slade, Dirk Masini, Brendan D. Owens, Brett D. TI Safety Analysis of All-Inside Arthroscopic Repair of Peripheral Triangular Fibrocartilage Complex SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article ID DORSAL SENSORY BRANCH; PARTIAL EXCISION; ARTICULAR DISK; ISOLATED TEARS; ULNAR NERVE; WRIST; MANAGEMENT; INJURIES; ANATOMY AB Purpose: The purpose of this study was to determine whether an all-inside peripheral triangular fibrocartilage complex (TFCC) repair using the FasT-Fix device (Smith & Nephew Endoscopy, Andover, MA) is safe by measuring the proximity of the anchors to ulnar-sided anatomic structures. Methods: Eleven fresh-frozen cadaveric wrists were thawed and placed in traction. Under direct arthroscopic visualization, an all-inside arthroscopic peripheral TFCC repair was completed by placing a single FasT-Fix device in a vertical mattress fashion. The wrists were then dissected to visualize the 2 anchors. The distance between these anchors and the flexor carpi ulnaris (FCU), extensor carpi ulnaris (ECU), and dorsal branch of the ulnar sensory nerve (DBUN) were measured with digital calipers and recorded. Results: The peripheral anchor averaged 4.2 mm (range, 0 to 14 mm) from the ECU tendon, 3.8 mm (range, 0 to 9 mm) from the DBUN, and 8.3 mm (range, 1 to 15 mm) from the FCU tendon. The central anchor averaged 9.6 mm (range, 2 to 15 mm) from the ECU tendon, 6.8 mm (range, 1 to 13 mm) from the DBUN, and 7.6 mm (range, 1 to 13 mm) from the FCU tendon. Conclusions: This study exposes some safety concerns with the all-inside peripheral TFCC repair using the FasT-Fix device, which was found to reside in close proximity to the ECU, FCU, and DBUN. In multiple wrists the anchors were noted to underlie the anatomic structure that we measured, making it possible to pierce these structures with the needle before deployment of the anchor. Clinical Relevance: Though technically feasible, all-inside arthroscopic repair of the peripheral TFCC risks injury to the ulnar-sided anatomy. C1 [Waterman, Scott M.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Slade, Dirk] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Masini, Brendan D.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Owens, Brett D.] Keller Army Community Hosp, West Point, NY USA. RP Waterman, SM (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM scott.m.waterman@us.army.mil FU US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX FX Supported by the US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX. The authors report no conflict of interest. NR 29 TC 8 Z9 8 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD NOV PY 2010 VL 26 IS 11 BP 1474 EP 1477 DI 10.1016/j.arthro.2010.02.027 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 672IY UT WOS:000283577700014 PM 20851562 ER PT J AU Luo, CY Chambers, C Pattabiraman, N Tong, M Tipparaju, P Saxena, A AF Luo, Chunyuan Chambers, Carolyn Pattabiraman, Nagarajan Tong, Min Tipparaju, Prasanthi Saxena, Ashima TI Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE Bovine acetylcholinesterase; Cyclosarin; VR; Oxime reactivation; Peripheral anionic site; Molecular modeling ID SOMAN; TABUN; METHYLPHOSPHONOFLUORIDATE; CHOLINESTERASES; OBIDOXIME; EFFICACY; DESIGN; MICE; HI-6; ANTIDOTES AB The toxicity of organophosphorus (OP) nerve agents is manifested through irreversible inhibition of acetylcholinesterase (AChE) at the cholinergic synapses, which stops nerve signal transmission, resulting in a cholinergic crisis and eventually death of the poisoned person. Oxime compounds used in nerve agent antidote regimen reactivate nerve agent-inhibited AChE and halt the development of this cholinergic crisis. Due to diversity in structures of OP nerve agents, none of the currently available oximes is able to reactivate AChE inhibited by different nerve agents. To understand the mechanism for the differential activities of oximes toward AChE inhibited by diverse nerve agents in order to aid the design of new broad-spectrum AChE reactivators, we undertook site-directed mutagenesis and molecular modeling studies. Recombinant wild-type and mutant bovine (Bo) AChEs were inhibited by two bulky side-chain nerve agents, GF and VR, and used for conducting reactivation kinetics with five oximes. A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack. Results revealed that the peripheral anionic site (PAS) of AChE as a whole plays a critical role in the reactivation of nerve agent-inhibited AChE by all 4 bis-pyridinium oximes examined, but not by the mono-pyridinium oxime 2-PAM. Of all the residues at the PAS, Y124 appears to be critical for the enhanced reactivation potency of H oximes. Published by Elsevier Inc. C1 [Luo, Chunyuan; Chambers, Carolyn; Pattabiraman, Nagarajan; Tong, Min; Tipparaju, Prasanthi; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Luo, CY (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chunyuan.luo@us.army.mil RI Pattabiraman, Nagarjan /A-9347-2011 FU Defense Threat Reduction Agency FX We thank Mr. Patrick Kates and Mr. Shawn Xiao for the excellent technical assistance and Dr. Robert diTargiani providing purified rabbit PON1. This work was supported by funding from the Defense Threat Reduction Agency. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the Department of Defense. NR 38 TC 11 Z9 11 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD NOV 1 PY 2010 VL 80 IS 9 BP 1427 EP 1436 DI 10.1016/j.bcp.2010.07.020 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 657JC UT WOS:000282408000014 PM 20655881 ER PT J AU Rothwell, SW Settle, T Wallace, S Dorsey, J Simpson, D Bowman, JR Janmey, P Sawyer, E AF Rothwell, Stephen W. Settle, Timothy Wallace, Shannon Dorsey, Jennifer Simpson, David Bowman, James R. Janmey, Paul Sawyer, Evelyn TI The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage SO BIOLOGICALS LA English DT Article DE Salmon; Hemostasis; Coagulation; Antibodies; Thrombin; Fibrinogen; Bandage ID TOPICAL BOVINE THROMBIN; HUMAN FACTOR-V; ANTIBODIES; MODEL; HEMORRHAGE; SURGERY; OPERATIONS; INHIBITORS; INJECTION; DRESSINGS AB Experimental salmon thrombin/fibrinogen dressings have been shown to provide effective hemostasis in severe hemorrhage situations The hypothesis for this study was that swine would still remain healthy without coagulopathy six months after exposure to salmon thrombin/fibrinogen dressings Initial exposure was by insertion of the salmon dressing into the peritoneal cavity Three months after the initial exposure the same animals were subjected to two full thickness dermal wounds on the dorsal surface One wound was bandaged with the salmon thrombin/fibrinogen bandage and the other wound was dressed with a standard bandage The animals were monitored for an additional three months Blood was drawn every 14 days over the six months for immunological and coagulation function analysis All of the animals (8 pigs) remained healthy during the six month period and the dermal wounds healed without incidence Lymph nodes and spleen showed signs of normal immune response and Western blots showed development of antibodies against salmon fibrinogen but none of the animals made antibodies that recognized any species of thrombin Coagulation parameters (fibrinogen concentration thrombin time PT and aPTT) and hematological parameters remained normal over the course of the study when compared to initial values of the subject swine Published by Elsevier Ltd on behalf of The International Association for Biologicals C1 [Rothwell, Stephen W.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Settle, Timothy] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. [Wallace, Shannon] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. [Dorsey, Jennifer] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD USA. [Simpson, David; Bowman, James R.] Virginia Commonwealth Univ, Dept Anat, Richmond, VA USA. [Janmey, Paul] Univ Penn, Inst Med Engn, Philadelphia, PA 19104 USA. [Sawyer, Evelyn] Sea Run Holdings, Freeport, ME USA. RP Rothwell, SW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. FU Office of Naval Research Arlington VA [N0001406MP20010]; Uniformed Services University of the Health Sciences Bethesda MD [R070TF]; US Army Military Research and Materiel Command Ft Detrick MD FX This research project was supported by funding from the Office of Naval Research Arlington VA (Project No N0001406MP20010) The Uniformed Services University of the Health Sciences Bethesda MD (R070TF) and by the US Army Military Research and Materiel Command Ft Detrick MD NR 43 TC 5 Z9 5 U1 0 U2 4 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1045-1056 J9 BIOLOGICALS JI Biologicals PD NOV PY 2010 VL 38 IS 6 BP 619 EP 628 DI 10.1016/j.biologicals.2010.07.001 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy GA 682IA UT WOS:000284393400002 PM 20705479 ER PT J AU Platten, WE Bailey, D Suidan, MT Maloney, SW AF Platten, William E., III Bailey, David Suidan, Makram T. Maloney, Stephen W. TI Biological transformation pathways of 2,4-dinitro anisole and N-methyl paranitro aniline in anaerobic fluidized-bed bioreactors SO CHEMOSPHERE LA English DT Article DE Insensitive munitions; 2,4-Dinitro anisole; N-methyl paranitto aniline; Ethanol; Anaerobic fluidized-bed bioreactors; Anaerobic transformation ID BIOTRANSFORMATION; DNAN AB The US Army is evaluating new, insensitive explosives to produce safer munitions. Two potential new components are 2,4-dinitro anisole (DNAN) and N-methyl paranitro aniline (MNA), which would eventually make their way to waste streams generated in the production and handling of new munitions. The effectiveness of anaerobic fluidized-bed bioreactors (AFBB) was studied for treatment and transformation of these two new chemical components in munitions. Each compound was fed into a separate reactor and monitored for removal and transformation, using ethanol as the electron donor. The results show that both were degradable using the AFBB system. DNAN was found to transform into diaminoanisole and MNA was found to transform into N-methyl-p-phenylenediamine. Both of these by-products appeared to form azobond polymers after exposure to air. To test the resilience of the reactors, the compounds were removed from the feed streams for 3 week and then reintroduced. DNAN showed that a re-acclimation period was necessary for it to be degraded again, while MNA was removed immediately upon reintroduction. The AFBB technology was shown here to be an effective means of removing the new munitions, but produce secondary compounds that could potentially be just as harmful and require further study. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Platten, William E., III; Bailey, David; Suidan, Makram T.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. [Maloney, Stephen W.] USA, Engn Res & Dev Ctr, CERL, Washington, DC USA. RP Suidan, MT (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. EM Makram.Suidan@uc.edu RI Motteran, Fabricio/F-8406-2012 OI Motteran, Fabricio/0000-0002-7664-2697 NR 17 TC 28 Z9 28 U1 1 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2010 VL 81 IS 9 BP 1131 EP 1136 DI 10.1016/j.chemosphere.2010.08.044 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 685WN UT WOS:000284658900012 PM 20855103 ER PT J AU Morris, MJ Christopher, KL AF Morris, Michael J. Christopher, Kent L. TI Diagnostic Criteria for the Classification of Vocal Cord Dysfunction SO CHEST LA English DT Article ID UPPER AIRWAY-OBSTRUCTION; EXERCISE-INDUCED ASTHMA; FUNCTIONAL INSPIRATORY STRIDOR; IRRITABLE LARYNX SYNDROME; FLOW-VOLUME CURVE; FOLD MOTION; PAROXYSMAL LARYNGOSPASM; GASTROESOPHAGEAL-REFLUX; INDUCED BRONCHOSPASM; BRONCHIAL-ASTHMA AB Vocal cord dysfunction (VCD) is a syndrome characterized by paroxysms of glottic obstruction due to true vocal cord adduction resulting in symptoms such as dyspneat and noisy breathing. Since first described as a distinct clinical entity in 1983, VCD has inadvertently become a collective term for a variety of clinical presentations due to glottic disorders. Despite an increased understanding of laryngeal function over the past 25 years, VCD remains a poorly understood and characterized entity. Disparities in the literature regarding etiology, pathophysiology, and management may be due to the historic approach to this patient population. Additionally, disorders clearly not due to paroxysms of true vocal cord adduction, such as laryngomalacia, vocal cord paresis, and CNS causes, need to be differentiated from VCD. Although a psychologic origin for VCD has been established, gastroesophageal reflux disease (GERD), nonspecific airway irritants, and exercise have also been associated with intermittent laryngeal obstruction with dyspnea and noisy breathing. VCD has been repeatedly misdiagnosed as asthma; however, the relationship between asthma and VCD is elusive. There are numerous case reports on VCD, but there is a paucity of prospective studies. Following an in-depth review of the medical literature, this article examines the available retrospective and prospective evidence to present an approach for evaluation of VCD including: (1) evaluation of factors associated with VCD, (2) differential diagnosis of movement disorders of the upper airway, and (3) clinical, spirometric, and endoscopic criteria for the diagnosis. CHEST 2010; 138(5):1213-1223 C1 [Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, Ft Sam Houston, TX 78234 USA. [Christopher, Kent L.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med MCHE MD, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.morris@amedd.army.mil NR 135 TC 58 Z9 58 U1 1 U2 10 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2010 VL 138 IS 5 BP 1213 EP 1223 DI 10.1378/chest.09-2944 PG 11 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 681TH UT WOS:000284341700030 PM 21051397 ER PT J AU Bandera, B Ainsworth, C Shikle, J Rupard, E Roach, M AF Bandera, Bradley Ainsworth, Craig Shikle, James Rupard, Erik Roach, Michael TI Treatment of Unicentric Castleman Disease With Neoadjuvant Rituximab SO CHEST LA English DT Article AB Angiofollicular lymph node hyperplasia, known more commonly as Castleman disease, is a rare lymphopro-liferative disorder. Castleman disease has two distinct clinical manifestations described as unicentric and multicentric disease. These presentations have distinct treatment algorithms and portend very different prognoses. Standard treatment of unicentric disease is complete surgical resection, which confers a cure rate approaching 100%. To our knowledge, this case report is the first to describe the use of neoadjuvant rituximab in the treatment of unicentric Castleman disease to enable a less morbid surgical resection. Given the vascularity of the tumor, proximity to the pulmonary artery and superior vena cava, and possible intimate association with the lung parenchyma, the tumor was treated preoperatively with rituximab, an anti-CD20 monoclonal antibody, at doses of 375 mg/m(2) weekly for 4 weeks. Rituximab therapy successfully decreased the diameter of the tumor from 4.79 cm X 2.67 cm to 2.8 cm X 1.5 cm, as confirmed by CT imaging. Postoperative surgical pathology confirmed the diagnosis of Castleman disease, hyaline vascular type, with negative margins. Notably, the lymph node tissue in the rituximab-treated specimen demonstrated reduced mantle zone thickness, decreased size of follicles, and increased hyalinization of vessels. Rituximab shows promise in neoadjuvant treatment of unresectable or partially resectable unicentric Castleman disease. CHEST 2010; 138(5):1239-1241 C1 [Roach, Michael] Eisenhower Army Med Ctr, Dept Cardiothorac Surg, Ft Gordon, GA 30905 USA. [Bandera, Bradley] Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. [Ainsworth, Craig] Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA. [Shikle, James] Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA. [Rupard, Erik] Eisenhower Army Med Ctr, Dept Med Oncol, Ft Gordon, GA 30905 USA. RP Roach, M (reprint author), Eisenhower Army Med Ctr, Dept Cardiothorac Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM michael.j.roach@amedd.army.mil FU Eisenhower Army Medical Center FX This study was performed at the Eisenhower Army Medical Center. NR 7 TC 18 Z9 19 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2010 VL 138 IS 5 BP 1239 EP 1241 DI 10.1378/chest.09-2084 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 681TH UT WOS:000284341700033 PM 21051400 ER PT J AU Scher, DL Belmont, PJ Owens, BD AF Scher, Danielle L. Belmont, Philip J., Jr. Owens, Brett D. TI Osteonecrosis of the Femoral Head after Hip Arthroscopy SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID BLOOD-FLOW; FOLLOW-UP; COMPLICATIONS; JOINT; TRACTION; PRESSURE; TAMPONADE; EPIPHYSIS; NECROSIS; DISEASE AB Background Hip arthroscopy is a common orthopaedic procedure used as a diagnostic and therapeutic tool with a multitude of surgical indications. The complication rate is reportedly between 1.3% and 23.3%. Major complications are related to traction, fluid extravasation, and iatrogenic chondral injury. Although osteonecrosis is a concern with any surgical procedure about the hip, this complication has been primarily a theoretical concern with hip arthroscopy. Case Description We report the case of a 24-year-old man who presented with a 2-year history of left hip pain. He underwent hip arthroscopy to include debridement of a torn labrum and removal of a prominent pincer lesion for femoroacetabular impingement. Traction was initiated by applying manual traction to the traction bar until 10 mm of joint distraction was obtained. Traction was removed at 90 minutes. At the 3-month followup, MRI showed osteonecrosis in the subcapital region of the left femoral head. Literature Review It generally is agreed the magnitude and duration of traction during hip arthroscopy increase the risk of traction-related injuries. Only one previous case of femoral head osteonecrosis associated with hip arthroscopy has been reported, and this may have resulted from the initial traumatic event. Based on anatomic studies, the use of standard arthroscopic portals would not put at risk any dominant normal vascular structures supplying the femoral head. In contrast, the literature shows that femoral head osteonecrosis may develop secondary to a combination of increased intraarticular pressure and traction. Purposes and Clinical Relevance We suspect this case of femoral head osteonecrosis after hip arthroscopy was caused by traction used in the procedure. C1 [Scher, Danielle L.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Orthopaed Surg Serv, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Hosp, Dept Orthopaed Surg, West Point, NY USA. RP Scher, DL (reprint author), William Beaumont Army Med Ctr, Orthopaed Surg Serv, 5005 N Piedras St, El Paso, TX 79920 USA. EM danielle.scher@amedd.army.mil NR 25 TC 23 Z9 23 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD NOV PY 2010 VL 468 IS 11 BP 3121 EP 3125 DI 10.1007/s11999-010-1256-1 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 735TE UT WOS:000288439900039 PM 20146035 ER PT J AU Lindemer, CA Plant, NG Puleo, JA Thompson, DM Wamsley, TV AF Lindemer, C. A. Plant, N. G. Puleo, J. A. Thompson, D. M. Wamsley, T. V. TI Numerical simulation of a low-lying barrier island's morphological response to Hurricane Katrina SO COASTAL ENGINEERING LA English DT Article DE XBeach; Barrier Islands; Coastal processes; Hurricanes; Chandeleur Islands; Numerical modeling ID BEHAVIOR MODEL; SCALE; LOUISIANA AB Tropical cyclones that enter or form in the Gulf of Mexico generate storm surge and large waves that impact low-lying coastlines along the Gulf Coast. The Chandeleur Islands, located 161 km east of New Orleans, Louisiana, have endured numerous hurricanes that have passed nearby. Hurricane Katrina (landfall near Waveland MS, 29 Aug 2005) caused dramatic changes to the island elevation and shape. In this paper the predictability of hurricane-induced barrier island erosion and accretion is evaluated using a coupled hydrodynamic and morphodynamic model known as XBeach. Pre- and post-storm island topography was surveyed with an airborne lidar system. Numerical simulations utilized realistic surge and wave conditions determined from larger-scale hydrodynamic models. Simulations included model sensitivity tests with varying grid size and temporal resolutions. Model-predicted bathymetry/topography and post-storm survey data both showed similar patterns of island erosion, such as increased dissection by channels. However, the model under predicted the magnitude of erosion. Potential causes for under prediction include (1) errors in the initial conditions (the initial bathymetry/topography was measured three years prior to Katrina), (2) errors in the forcing conditions (a result of our omission of storms prior to Katrina and/or errors in Katrina storm conditions), and/or (3) physical processes that were omitted from the model (e.g., inclusion of sediment variations and bio-physical processes). Published by Elsevier B.V. C1 [Lindemer, C. A.; Puleo, J. A.] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Plant, N. G.; Thompson, D. M.] US Geol Survey, St Petersburg, FL USA. [Wamsley, T. V.] USA, Corps Engineers, Vicksburg, MS 39180 USA. RP Puleo, JA (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. EM jpuleo@udel.edu OI Plant, Nathaniel/0000-0002-5703-5672 FU University of Delaware; U.S. Geological Survey FX We would like to thank Kristy Guy (USGS) for drafting and image processing, Wayne Wright for lidar instrumentation development, and Charlene Sullivan (formerly with USGS) for lidar processing. Jim Flocks graciously provided his bathymetric data for construction of the morphology used to initialize the model. This work was funded by the University of Delaware and the U.S. Geological Survey's Coastal and Marine Geology Program. NR 23 TC 28 Z9 28 U1 4 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD NOV-DEC PY 2010 VL 57 IS 11-12 BP 985 EP 995 DI 10.1016/j.coastaleng.2010.06.004 PG 11 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 659IQ UT WOS:000282560600003 ER PT J AU Hamoush, S Abu-Lebdeh, T Cummins, T AF Hamoush, Sameer Abu-Lebdeh, Taher Cummins, Toney TI Deflection behavior of concrete beams reinforced with PVA micro-fibers SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE Deflection; Moment-curvature; Stress-strain; Micro-fibers reinforced concrete; Flexural strength; Strain-softening; Ductility; Toughness index; Load-deflection curve ID COMPOSITES; MODEL AB This paper presents experimental and theoretical investigations on the stress-strain and load-deflection behavior of Poly Vinyl Alcohol (PVA) microfiber reinforced concrete composites. The actual stress-strain relationships in both compression and tension were established by performing a series of compression and tension tests on PVA micro-fibers reinforced concrete specimens. The proposed deflection model was developed by using the well known moment-curvature and conjugate beam methods. Comparisons with the experimental data indicated that the model can be efficiently used to predict the load-deflection behavior of the microfiber reinforced concrete beams. Flexural results indicated that the addition of PVA micro-fibers significantly increases toughness and ductility. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Hamoush, Sameer; Abu-Lebdeh, Taher] N Carolina Agr & Tech State Univ, Dept Civil Architectural & Environm Engn, Greensboro, NC 27411 USA. [Cummins, Toney] USA, Corps Engineers, Concrete & Mat Div, Vicksburg, MS 39180 USA. RP Abu-Lebdeh, T (reprint author), N Carolina Agr & Tech State Univ, Dept Civil Architectural & Environm Engn, Greensboro, NC 27411 USA. EM taher@ncat.edu FU US Army Corps of Engineers (ERDC) FX The authors would like to thank the US Army Corps of Engineers (ERDC) for funding of this research. NR 15 TC 15 Z9 16 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD NOV PY 2010 VL 24 IS 11 BP 2285 EP 2293 DI 10.1016/j.conbuildmat.2010.04.027 PG 9 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 636XV UT WOS:000280778700031 ER PT J AU Derdak, S Cannon, JW AF Derdak, Stephen Cannon, Jeremy W. TI 'Rescue oxygenation therapies' for severe pH1N1-associated acute respiratory distress syndrome SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE H1N1; influenza; extracorporeal membrane oxygenation (ECMO); high-frequency oscillatory ventilation (HFOV); acute respiratory distress syndrome (ARDS); rescue therapy ID EXTRACORPOREAL MEMBRANE-OXYGENATION; 2009 INFLUENZA A(H1N1); ACUTE LUNG INJURY; VENTILATION C1 [Derdak, Stephen] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Cannon, Jeremy W.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Derdak, S (reprint author), Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. NR 16 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD NOV PY 2010 VL 38 IS 11 BP 2257 EP 2258 DI 10.1097/CCM.0b013e3181f848e1 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 667YW UT WOS:000283235400026 PM 20959754 ER PT J AU Rickards, CA Ryan, KL Ludwig, DA Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Ludwig, David A. Convertino, Victor A. TI Trauma patients with normal vital signs: Is shock index a reflection of injury severity? Reply SO CRITICAL CARE MEDICINE LA English DT Letter C1 [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78285 USA. [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ludwig, David A.] Univ Miami, Dept Pediat, Div Clin Res, Miller Sch Med, Miami, FL 33152 USA. RP Rickards, CA (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78285 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD NOV PY 2010 VL 38 IS 11 BP 2269 EP 2270 DI 10.1097/CCM.0b013e3181f849fb PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 667YW UT WOS:000283235400036 ER PT J AU He, WJ Castiblanco, J Walter, EA Okulicz, JF Ahuja, SK AF He, Weijing Castiblanco, John Walter, Elizabeth A. Okulicz, Jason F. Ahuja, Sunil K. TI Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes SO CURRENT OPINION IN HIV AND AIDS LA English DT Article DE biomarker; chemokine; gene; HIV; Mendelian randomization ID HUMAN-IMMUNODEFICIENCY-VIRUS; DUFFY ANTIGEN RECEPTOR; C-REACTIVE PROTEIN; COPY-NUMBER VARIATION; CD4(+) T-CELLS; DISEASE PROGRESSION; ANTIRETROVIRAL THERAPY; PROMOTER POLYMORPHISM; TYPE-1 INFECTION; AIDS SUSCEPTIBILITY AB Purpose of review It is unknown whether biomarkers simply correlate with or are causal for HIV-associated outcomes. Mendelian randomization is a genetic epidemiologic approach used to disentangle causation from association. Here, we discuss the potential use of Mendelian randomization for differentiating whether biomarkers are correlating with or causal for HIV-associated outcomes. Recent findings Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. A formal Mendelian randomization study using a genetic marker as a proxy for the biomarker has not been conducted in the HIV field. However, in the postgenomic era, this approach is being used increasingly. Examples are evidence for the causal role of BMI in blood pressure and noncausal role of C-reactive protein in coronary heart disease. We discuss the conceptual framework, uses, and limitations of Mendelian randomization in the context of HIV infection as well as specific biomarkers (IL-6, C-reactive protein) and genetic determinants (e. g., in CCR5, chemokine, and DARC genes) that associate with HIV-related outcomes. Summary Making the distinction between correlation and causality has particular relevance when a biomarker (e. g., IL-6) is potentially modifiable, in which case a biomarker-guided targeted treatment strategy may be feasible. Although the tenets of Mendelian randomization rest on strong assumptions, and conducting a Mendelian randomization study in HIV infection presents many challenges, it may offer the potential to identify causal biomarkers for HIV-associated outcomes. C1 [He, Weijing; Castiblanco, John; Ahuja, Sunil K.] S Texas Vet Healthcare Syst, Vet Adm Res Ctr AIDS & HIV Infect 1, San Antonio, TX USA. [He, Weijing; Castiblanco, John; Walter, Elizabeth A.; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Biochem, San Antonio, TX 78229 USA. [Okulicz, Jason F.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Ahuja, SK (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Vet Adm Ctr AIDS & HIV Infect, 7703 Floyd Curl Dr MC 7881,Rm 5-065R, San Antonio, TX 78229 USA. EM ahujas@uthscsa.edu OI CASTIBLANCO, JOHN/0000-0003-2556-3697; CASTIBLANCO, JOHN/0000-0002-7965-9822 FU Veterans Administration HIV/AIDS Center of the South Texas Veterans Healthcare System, NIH [R37046326]; Doris Duke Distinguished Clinical Scientist Award; VA MERIT award; Burroughs Wellcome Clinical Scientist Award in Translational Research FX The present work was supported by the Veterans Administration HIV/AIDS Center of the South Texas Veterans Healthcare System, NIH (R37046326), and the Doris Duke Distinguished Clinical Scientist Award to S. K. A. S. K. A. is also supported by a VA MERIT award and the Burroughs Wellcome Clinical Scientist Award in Translational Research. NR 140 TC 1 Z9 1 U1 1 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD NOV PY 2010 VL 5 IS 6 BP 545 EP 559 DI 10.1097/COH.0b013e32833f2087 PG 15 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 828NX UT WOS:000295509900014 PM 20978399 ER PT J AU Palmer, B Xia, Y Cho, SH Lewis, FS AF Palmer, Benjamin Xia, Yang Cho, Sunghun Lewis, Felicia S. TI Acroangiodermatitis Secondary to Chronic Venous Insufficiency SO CUTIS LA English DT Article ID ACROANGLODERMATITIS; FOOT AB Acroangiodermatitis (AAD) is a benign uncommon vasoproliferative disorder that affects the lower extremities It appears to be a reactive phenomenon related to severe chronic venous insufficiency and stasis of the lower extremities The clinical presentation of this condition often is similar to Kaposi sarcoma We report a case of AAD in a patient with severe hypertension and chronic venous insufficiency Cutis 2010 86 239-240 C1 [Palmer, Benjamin] W Virginia Sch Osteopath Med, Morgantown, WV USA. [Xia, Yang] Evans Army Community Hosp, Dermatol Clin, Ft Carson, CO 80913 USA. [Cho, Sunghun] Darnall Army Community Hosp, Dermatol Clin, Ft Hood, TX USA. [Lewis, Felicia S.] Walter Reed Army Med Ctr, Dermatol Serv, Natl Capital Consortium, Dermatol Residency Program, Washington, DC 20307 USA. RP Xia, Y (reprint author), Evans Army Community Hosp, Dermatol Clin, Room 2228,1650 Cochrane Cir, Ft Carson, CO 80913 USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2010 VL 86 IS 5 BP 239 EP 240 PG 2 WC Dermatology SC Dermatology GA 689JL UT WOS:000284923800005 PM 21214123 ER PT J AU Adair, J Gromski, MA Lim, RB Nagle, D AF Adair, James Gromski, Mark A. Lim, Robert B. Nagle, Deborah TI Single-Incision Laparoscopic Right Colectomy: Experience With 17 Consecutive Cases and Comparison With Multiport Laparoscopic Right Colectomy SO DISEASES OF THE COLON & RECTUM LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Colon-and-Rectal-Surgeons CY MAY 15-19, 2010 CL Minneapolis, MN SP Amer Soc Colon & Rectal Surg DE Benign abdominal; Laparoscopy; Abdominal malignancy; Colon cancer; Colon and rectal surgery ID RIGHT HEMICOLECTOMY; SLEEVE GASTRECTOMY; PORT; CHOLECYSTECTOMY; SURGERY; ADRENALECTOMY; SILS AB BACKGROUND: Recently, single-incision laparoscopic surgery has begun to develop as an extension of standard laparoscopic minimally invasive procedures. However, there have been a limited number of reports of single-incision procedures in colorectal disease. PURPOSE: The aim of this study is to describe our initial experience with single-incision laparoscopic right colectomy and to make comparisons with the current standard of care, multiport laparoscopic right colectomy. METHODS: Data from consecutive patients undergoing single-incision laparoscopic right colectomy were analyzed and compared with case-matched multiport laparoscopic right colectomies. Indications for surgery, type of port used, operative time, number of nodes harvested, length of hospital stay, and complications were the outcomes measured. RESULTS: During the study period, 17 patients underwent single-incision laparoscopic colectomy. Of the planned single-incision laparoscopic cases, 15 (88%) were completed with a single incision, whereas 2 required an additional port placement. There were no conversions to open surgery during any of the cases. Indications for surgery were similar between the 2 groups. Operative time was not significantly different in single-incision laparoscopic right colectomy compared with multiport laparoscopic right colectomy (139 min vs 134 min, respectively; P = .61). Length of stay and number of nodes harvested also had no significant differences between the 2 groups. There was one death after discharge to home secondary to pulmonary embolism and one delayed thermal injury in the single-incision laparoscopic group. CONCLUSION: Single-incision laparoscopic right colectomy is feasible, and appears to have results similar to standard multiport right colectomy in our initial comparisons. Ongoing development in instrumentation may help to further shorten operative time and minimize complications, and may make this an equivalent or preferred method for minimally invasive colorectal surgery. Large, prospective, randomized, controlled trials should be conducted to further compare the safety and efficacy of this approach. C1 [Adair, James] Harvard Univ, Beth Israel Deaconess Med Ctr, Sect Minimally Invas Surg, Sch Med,Dept Surg, Boston, MA 02215 USA. [Lim, Robert B.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Nagle, Deborah] Harvard Univ, Beth Israel Deaconess Med Ctr, Div Colon & Rectal Surg, Sch Med, Boston, MA 02215 USA. RP Nagle, D (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sect Minimally Invas Surg, Sch Med,Dept Surg, Stoneman 9,330 Brookline Ave, Boston, MA 02215 USA. EM dnagle@bidmc.harvard.edu NR 30 TC 72 Z9 75 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0012-3706 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD NOV PY 2010 VL 53 IS 11 BP 1549 EP 1554 DI 10.1007/DCR.0b013e3181e85875 PG 6 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 664DN UT WOS:000282939600014 PM 20940605 ER PT J AU Morton, RA Bernier, JC Kelso, KW Barras, JA AF Morton, Robert A. Bernier, Julie C. Kelso, Kyle W. Barras, John A. TI Quantifying large-scale historical formation of accommodation in the Mississippi Delta SO EARTH SURFACE PROCESSES AND LANDFORMS LA English DT Article DE subsidence; erosion; wetland loss; bathymetry; remote sensing; imagery analysis ID PLAIN; LAND AB Large volumes of new accommodation have formed within the Mississippi Delta plain since the mid-1950s in association with rapid conversion of coastal wetlands to open water. The three-dimensional aspects and processes responsible for accommodation formation were quantified by comparing surface elevations, water depths, and vertical displacements of stratigraphic contacts that were correlated between short sediment cores. Integration of data from remotely sensed images, sediment cores, and water-depth surveys at 10 geologically diverse areas in the delta plain provided a basis for estimating the total volume of accommodation formed by interior-wetland subsidence and subsequent erosion. Results indicate that at most of the study areas subsidence was a greater contributor than erosion to the formation of accommodation associated with wetland loss. Tens of millions of cubic meters of accommodation formed rapidly at each of the large open-water bodies that were formerly continuous interior delta-plain marsh. Together the individual study areas account for more than 440 x 10(6) m(3) of new accommodation that formed as holes in the Mississippi River delta-plain fabric between 1956 and 2004. This large volume provides an estimate of the new sediment that would be needed just at the study areas to restore the delta-plain wetlands to their pre-1956 areal extent and elevations. Published 2010. This article is a US Government work and is in the public domain in the USA. C1 [Morton, Robert A.] US Geol Survey, Austin, TX 78758 USA. [Bernier, Julie C.] US Geol Survey, St Petersburg, FL USA. [Kelso, Kyle W.] Jacobs Technol Inc, St Petersburg, FL USA. [Barras, John A.] US Army Engineer Res & Dev Ctr, Environm Lab, Baton Rouge Off, Baton Rouge, LA USA. RP Morton, RA (reprint author), US Geol Survey, 10100 Burnet Rd,Bldg 130, Austin, TX 78758 USA. EM rmorton@usgs.gov NR 30 TC 6 Z9 7 U1 1 U2 9 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0197-9337 J9 EARTH SURF PROC LAND JI Earth Surf. Process. Landf. PD NOV PY 2010 VL 35 IS 14 BP 1625 EP 1641 DI 10.1002/esp.2000 PG 17 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 678DI UT WOS:000284051300001 ER PT J AU Leverenz, HL Haunschild, K Hopes, G Tchobanoglous, G Darby, JL AF Leverenz, Harold L. Haunschild, Kristine Hopes, Guy Tchobanoglous, George Darby, Jeannie L. TI Anoxic treatment wetlands for denitrification SO ECOLOGICAL ENGINEERING LA English DT Article DE Anoxic constructed wetland; Subsurface flow; Woodchips; Denitrification; Decentralized wastewater management; Nitrate removal ID NITRATE REMOVAL; ARTIFICIAL WETLANDS; SEPTIC SYSTEMS; GROUNDWATER; REMEDIATION; WASTEWATER; NITROGEN; BARRIERS; RATES AB Anoxic subsurface flow (SSF) constructed wetlands were evaluated for denitrification using nitrified wastewater. The treatment wetlands utilized a readily available organic woodchip-media packing to create the anoxic conditions. After 2 years in operation, nitrate removal was found to be best described by first-order kinetics. Removal rate constants at 20 degrees C (k(20)) were determined to be 1.41-1.30d(-1), with temperature coefficients (theta) of 1.10 and 1.17, for planted and unplanted experimental woodchip-media SSF wetlands, respectively. First-order removal rate constants decreased as length of operation increased: however, a longer-term study is needed to establish the steady-state values. The hydraulic conductivity in the planted woodchip-media SSF wetlands, 0.13-0.15 m/s, was similar to that measured in an unplanted gravel-media SSF control system. (C) 2010 Elsevier B.V. All rights reserved. C1 [Leverenz, Harold L.; Hopes, Guy; Tchobanoglous, George; Darby, Jeannie L.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Haunschild, Kristine] US Army Corps Engn, Sacramento, CA 95814 USA. RP Darby, JL (reprint author), Univ Calif Davis, Dept Civil & Environm Engn, 1 Shields Ave, Davis, CA 95616 USA. EM jdarby@ucdavis.edu FU Water Environment Research Foundation [DEC13U06]; California Department of Transportation FX This research was supported by the Water Environment Research Foundation Contract # DEC13U06 and the California Department of Transportation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. Woodchips were provided by Waste Management, Inc. (WMCR/K&M, Sacramento, CA). The septic tank, nitrification filters, and SSF basins were provided by Orenco Systems Inc. (Sutherlin, OR). NR 32 TC 27 Z9 29 U1 1 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD NOV PY 2010 VL 36 IS 11 SI SI BP 1544 EP 1551 DI 10.1016/j.ecoleng.2010.03.014 PG 8 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 665BS UT WOS:000283010600005 ER PT J AU Zhu, W Zheng, JP Liang, R Wang, B Zhang, C Au, G Plichta, EJ AF Zhu, W. Zheng, J. P. Liang, R. Wang, B. Zhang, C. Au, G. Plichta, E. J. TI Ultra-low platinum loading high-performance PEMFCs using buckypaper-supported electrodes SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE PEMFCs; Carbon nanotube; Carbon nanofiber; Gradient structure ID CATHODE CATALYST LAYERS; FUEL-CELLS; OXYGEN REDUCTION AB The microstructure of the catalyst layer in proton exchange membrane fuel cells (PEMFCs) greatly influences catalyst (Pt) utilization and cell performance. We demonstrated a functionally graded catalyst layer based on a double-layered carbon nanotube/nanofiber film- (bucicypaper) supported Pt composite catalyst to approach an idealized microstructure. The gradient distribution of Pt, electrolyte and porosity along the thickness effectively depresses the transport resistance of proton and gas. A rated power of 0.88 W/cm(2) at 0.65 V was achieved at 80 C with a low Pt loading of 0.11 mg/cm(2) resulting in a relatively high Pt utilization of 0.18g(pt)/kW. The accelerated degradation test of catalyst support showed a good durability of buckypaper support because of the high graphitization degree of carbon nanofibers. (C) 2010 Elsevier B.V. All rights reserved. C1 [Zhu, W.; Zheng, J. P.] Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Zhu, W.; Zheng, J. P.; Liang, R.; Wang, B.; Zhang, C.] Florida State Univ, Tallahassee, FL 32310 USA. [Zhu, W.; Liang, R.; Wang, B.; Zhang, C.] Florida A&M Univ, Dept Ind & Mfg Engn, Tallahassee, FL 32310 USA. [Au, G.; Plichta, E. J.] USA, CERDEC, Ft Monmouth, NJ 07703 USA. RP Zheng, JP (reprint author), Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM zheng@eng.fsu.edu RI Zhu, Wei/B-4159-2010 FU Army CERDEC FX This research is partially supported by Army CERDEC. NR 16 TC 12 Z9 14 U1 4 U2 32 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD NOV PY 2010 VL 12 IS 11 BP 1654 EP 1657 DI 10.1016/j.elecom.2010.09.019 PG 4 WC Electrochemistry SC Electrochemistry GA 682FF UT WOS:000284386100050 ER PT J AU McKinney, RA Oczkowski, AJ Prezioso, J Hyde, KJW AF McKinney, R. A. Oczkowski, A. J. Prezioso, J. Hyde, K. J. W. TI Spatial variability of nitrogen isotope ratios of particulate material from Northwest Atlantic continental shelf waters SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE nitrogen; stable isotope; continental shelf; particulate material; estuary; chlorophyll-a ID STABLE-ISOTOPE; COASTAL WATERS; ATMOSPHERIC NITROGEN; ORGANIC-MATTER; UNITED-STATES; FOOD-WEB; NITRATE; OCEAN; PHYTOPLANKTON; ECOSYSTEMS AB Human encroachment on the coastal zone has led to concern about the impact of anthropogenic nitrogen (N) on estuarine and continental shelf waters. Western North Atlantic watershed budgets suggest that the export of human-derived N from estuaries to shelf waters off the east coast of the US may be significant: however, models based on water inputs and estimates of upwelling of deepwater nutrients to surface waters of the mid-Atlantic bight indicate that estuarine N may be a relatively minor component of the overall shelf N budget. Stable N isotope ratios could provide a means to assess the relative input of anthropogenic N to shelf waters, particularly since dissolved N from human sources has elevated delta(15)N values (range: 7-30 parts per thousand). We collected particulate material from surface shelf waters off the US east coast from 2000 to 2005 at near-shore sample sites proximal to the mouth of six estuaries and corresponding sites farther offshore. Near-shore (mean 33.7 km from estuary mouth) delta(15)N values ranged from 5.5 to 7.7 parts per thousand, Offshore values (mean 92.4 km from estuary mouth) were consistently lower than near-shore sites (average 4.7 +/- 1.0 parts per thousand versus 6.8 +/- 1.1 parts per thousand)(,) suggesting different N sources to near and offshore stations. Near-shore regions are often more productive, as mean monthly chlorophyll-a concentrations from the sea-viewing wide field-of-view sensor (SeaWiFS) were significantly higher at near-shore sites near the mouth of three of the six estuaries. A mass balance using a concentration-dependent mixing model with chlorophyll-a concentrations as a surrogate for dissolved inorganic nitrogen can account for all of the nitrogen at near-shore sites south of Cape Cod with estuarine nitrogen estimated to contribute 45-85% of the nitrogen to the near-shore surface particulate material. Our results support the hypothesis that estuarine nitrogen is influencing continental shelf ecosystems, and also provide preliminary evidence of the spatial extent of its influence on shelf waters in the mid-Atlantic bight. Published by Elsevier Ltd. C1 [McKinney, R. A.; Oczkowski, A. J.] USA, US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Atlantic Eco, Narragansett, RI 02882 USA. [Prezioso, J.; Hyde, K. J. W.] NOAA, Natl Marine Fisheries Serv, NE Fisheries Sci Ctr, Narragansett Lab, Narragansett, RI 02882 USA. RP McKinney, RA (reprint author), USA, US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Atlantic Eco, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM mckinney.rick@epa.gov OI Oczkowski, Autumn/0000-0002-2421-0956 FU U.S. Environmental Protection Agency FX We thank Joe Kane for assistance with sample collection and data analysis. Also many thanks to John O'Reilly for providing chlorophyll-a data and Teresa Ducas for help with data processing. We are grateful to Scott Nixon, Richard Pruell and Mark Cantwell for their critical review and helpful comments that greatly improved the manuscript. Mention of trade names or commercial products does not constitute endorsement or recommendation. Although the research described in this article has been funded wholly by the U.S. Environmental Protection Agency, it has not been subjected to Agency-level review. Therefore, it does not necessarily reflect the views of the Agency. This is the Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division contribution number AED-08-083. NR 57 TC 9 Z9 9 U1 3 U2 16 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD NOV 1 PY 2010 VL 89 IS 4 BP 287 EP 293 DI 10.1016/j.ecss.2010.08.004 PG 7 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 664ZF UT WOS:000283002100005 ER PT J AU Cobb, W Anderson, A Turner, C Hoffman, RD Schonberg, S Levin, SW AF Cobb, William Anderson, Arne Turner, Clesson Hoffman, Ruth D. Schonberg, Steven Levin, Sondra W. TI 1.3 Mb de novo deletion in chromosome band 3q29 associated with normal intelligence in a child SO EUROPEAN JOURNAL OF MEDICAL GENETICS LA English DT Article DE Deletion 3q29; IQ; Autism; Array CGH analysis ID MICRODELETION; REARRANGEMENTS AB We report on a 6 and 9/12 year-old male patient with a de novo chromosome 3q29 microdeletion identified by BAC array comparative genomic hybridization assay (aCGH), with accompanying normal 46, XY high-resolution chromosome analysis. The patient has language-based learning disabilities and behavioral features consistent with diagnoses of autism and attention deficit hyperactivity disorder (ADHD) of the inattentive type. He also displays some other features previously associated with chromosome 3q29 microdeletion such as an elongated face, long fingers, and joint laxity. Most notably our patient, per formal IQ testing, was not found to have frank mental retardation as has been previously reported among patients with chromosome 3q29 terminal deletion, but rather our patient has demonstrated an average full-scale IQ result. Our report further expands the phenotypic spectrum of the rare chromosome 3q29 microdeletion syndrome to include the possibility of normal intelligence as corroborated by formal, longitudinal psycho-educational testing. Published by Elsevier Masson SAS. C1 [Turner, Clesson; Levin, Sondra W.] Walter Reed Army Med Ctr, Dept Pediat, Div Genet, Washington, DC 20307 USA. [Cobb, William; Anderson, Arne; Hoffman, Ruth D.] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD 20889 USA. [Schonberg, Steven] Quest Diagnost Nichols Inst, Chantilly, VA 20153 USA. RP Levin, SW (reprint author), Walter Reed Army Med Ctr, Dept Pediat, Div Genet, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Sondra.Levin@us.army.mil NR 10 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1769-7212 J9 EUR J MED GENET JI Eur. J. Med. Genet. PD NOV-DEC PY 2010 VL 53 IS 6 BP 415 EP 418 DI 10.1016/j.ejmg.2010.08.009 PG 4 WC Genetics & Heredity SC Genetics & Heredity GA 692WP UT WOS:000285186900014 PM 20832509 ER PT J AU Sulkowski, MS Shiffman, ML Afdhal, NH Reddy, KR McCone, J Lee, WM Herrine, SK Harrison, SA Poordad, FF Koury, K Deng, WP Noviello, S Pedicone, LD Brass, CA Albrecht, JK McHutchison, JG AF Sulkowski, Mark S. Shiffman, Mitchell L. Afdhal, Nezam H. Reddy, K. Rajender McCone, Jonathan Lee, William M. Herrine, Steven K. Harrison, Stephen A. Poordad, F. Fred Koury, Kenneth Deng, Weiping Noviello, Stephanie Pedicone, Lisa D. Brass, Clifford A. Albrecht, Janice K. McHutchison, John G. CA IDEAL Study Team TI Hepatitis C Virus Treatment-Related Anemia Is Associated With Higher Sustained Virologic Response Rate SO GASTROENTEROLOGY LA English DT Article DE Adverse Effects of Hepatitis Therapy; Clinical Trial; Liver Disease; Blood Disorders ID INTERFERON-ALPHA-2B PLUS RIBAVIRIN; HCV-INFECTED PATIENTS; RED-CELL APLASIA; EPOETIN-ALPHA; COMBINATION THERAPY; PEGYLATED INTERFERON-ALPHA-2B; PEGINTERFERON ALPHA-2A; GENOTYPE-1 PATIENTS; GROWTH-FACTORS; MANAGEMENT AB BACKGROUND & AIMS: Hepatitis C virus (HCV) treatment is frequently complicated by anemia from ribavirin (RBV)-related hemolysis and peginterferon-alfa (PEG-IFN)-related bone marrow suppression. We investigated the relationships among treatment outcomes, anemia, and their management with RBV dose reduction and/or erythropoiesis-stimulating agents (ESAs). METHODS: We analyzed data from a trial conducted at 118 United States academic and community centers in treatment-naive patients with HCV genotype 1. Patients were treated for as many as 48 weeks with 1 of 3 PEG-IFN/RBV regimens. ESAs were permitted for anemic patients (hemoglobin [Hb] < 10 g/dL) after RBV dose reduction. Sustained virologic responses (SVR) were assessed based on decreases in Hb, anemia, and ESA use. RESULTS: While patients received treatment, 3023 had their Hb levels measured at least once. An SVR was associated with the magnitude of Hb decrease: >3 g/dL, 43.7%; <= 3 g/dL, 29.9% (P < .001). Anemia occurred in 865 patients (28.6%); 449 of these (51.9%) used ESAs. In patients with early-onset anemia (<= 8 weeks of treatment), ESAs were associated with higher SVR rate (45.0% vs 25.9%; P < .001) and reduced discontinuation of treatment because of adverse events (12.6% vs 30.1%, P < .001). ESAs did not affect SVR or discontinuation rates among patients with late-stage anemia. CONCLUSIONS: Among HCV genotype 1-infected patients treated with PEG-IFN/RBV, anemia was associated with higher rates of SVR. The effect of ESAs varied by time to anemia; patients with early-onset anemia had higher rates of SVR with ESA use, whereas no effect was observed in those with late-onset anemia. Prospective trials are needed to assess the role of ESAs in HCV treatment. C1 [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Shiffman, Mitchell L.] Liver Inst Virginia, Bon Secours Hlth Syst, Newport News, VA USA. [Afdhal, Nezam H.] Beth Israel Liver Ctr, Boston, MA USA. [Reddy, K. Rajender] Univ Penn Hlth Syst, Philadelphia, PA USA. [McCone, Jonathan] Mt Vernon Endoscopy Ctr, Alexandria, VA USA. [Lee, William M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Herrine, Steven K.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Poordad, F. Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Koury, Kenneth; Deng, Weiping; Noviello, Stephanie; Pedicone, Lisa D.; Brass, Clifford A.; Albrecht, Janice K.] Merck & Co Inc, Whitehouse Stn, NJ USA. [McHutchison, John G.] Duke Clin Res Inst, Durham, NC USA. RP Sulkowski, MS (reprint author), Johns Hopkins Univ, Sch Med, 600 N Wolfe St,1830 Bldg,Suite 445, Baltimore, MD 21287 USA. EM msulkowski@jhmi.edu FU Schering-Plough; Roche; Gilead; Merck Co; Vertex Pharmaceuticals; Biolex; Bristol-Myers Squibb; Coley Pharmaceuticals; Conatus Pharmaceuticals; GlaxoSmithKline; GlobeImmune; Idenix; Johnson Johnson; Pfizer; Pharmassett; Romark Laboratories; Tibotec; Valeant; Wyeth; ZymoGenetics; Debio Pharmaceuticals; Duke University Medical Center; Peregrine Pharmaceuticals; Beckman FX The authors disclose the following: J.G. McHutchison (consultant or advisor: Schering-Plough), M. L. Shiffman (consultant or advisor: Gilead, Roche, Schering-Plough, Vertex Pharmaceuticals, ZymoGenetics), J. McCone (consultant or advisor: Roche, Schering-Plough), M. S. Sulkowski (consultant or advisor: Roche, Schering-Plough), W. M. Lee (consultant or advisor: Gilead, Lilly, Novartis, Westat); J. G. McHutchison (lecture fees: Schering-Plough), J. McCone (lecture fees: Roche, Schering-Plough), W. M. Lee (lecture fees: Schering-Plough), M. S. Sulkowski (lecture fees: Roche, Schering-Plough), M. L. Shiffman (lecture fees: Gilead, Roche); F. F. Poordad (investigator: Bristol-Myers Squibb, Gilead, GlaxoSmithKline, Human Genome Sciences, Idenix, Intarcia, Intermune, Novartis, Roche, Schering-Plough, Valeant, Vertex, Wyeth); F. F. Poordad (speaker bureau: Gilead, Novartis, Schering- Plough, Valeant); S. Noviello is former employee and current consultant of Schering-Plough (now Merck & Co.); C. A. Brass, W. Deng, K. Koury, L. D. Pedicone, and J. K. Albrecht are employees of Schering-Plough (now Merck & Co.) and are stock holders in this entity.; Supported by Schering-Plough Research Institute (now Merck & Co) for the study and research. Grant support by Roche (to J.G.M., M.L.S., and M.S.S.), Schering-Plough (to J.G.M., M.L.S., J.M., and M.S.S.), Vertex Pharmaceuticals (to J.G.M., M.L.S., M.S.S., and W.M.L); Biolex (to M.L.S.), Bristol-Myers Squibb (to M.L.S. and W.M.L.), Coley Pharmaceuticals (to M.L.S.), Conatus Pharmaceuticals (to M.L.S.), Gilead (to M.L.S.), GlaxoSmithKline (to M.L.S.and W.M.L.), GlobeImmune (to M.L.S.and W.M.L.), Idenix (to M.L.S.), Johnson & Johnson (to M.L.S.), Pfizer (to M.L.S.), Pharmassett (to M.L.S.), Romark Laboratories (to M.L.S.), Tibotec (to M.L.S.), Valeant (to M.L.S.), Wyeth (to M.L.S.), ZymoGenetics) (to M.L.S.); Debio Pharmaceuticals (to M.S.S.), Duke University Medical Center (to M.S.S.), Peregrine Pharmaceuticals (to M.S.S.); Beckman (to W.M.L.) and GlobeImmune (to W.M.L.). NR 36 TC 77 Z9 79 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD NOV PY 2010 VL 139 IS 5 BP 1602 EP + DI 10.1053/j.gastro.2010.07.059 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 673HW UT WOS:000283651100036 PM 20723545 ER PT J AU Masuoka, P Klein, TA Kim, HC Claborn, DM Achee, N Andre, R Chamberlin, J Small, J Anyamba, A Lee, DK Yi, SH Sardelis, M Ju, YR Grieco, J AF Masuoka, Penny Klein, Terry A. Kim, Heung-Chul Claborn, David M. Achee, Nicole Andre, Richard Chamberlin, Judith Small, Jennifer Anyamba, Assaf Lee, Dong-Kyu Yi, Suk H. Sardelis, Michael Ju, Young-Ran Grieco, John TI Modeling the distribution of Culex tritaeniorhynchus to predict Japanese encephalitis distribution in the Republic of Korea SO GEOSPATIAL HEALTH LA English DT Article DE Culex tritaeniorhynchus; geographical distribution; ecological niche modeling; Japanese encephalitis virus; Republic of Korea ID SPECIES DISTRIBUTIONS; ECOLOGY; VECTORS; AREAS AB Over 35,000 cases of Japanese encephalitis (JE) are reported worldwide each year. Culex tritaeniorhynchus is the primary vector of the JE virus, while wading birds are natural reservoirs and swine amplifying hosts. As part of a JE risk analysis, the ecological niche modeling programme, Maxent, was used to develop a predictive model for the distribution of Cx. tritaeniorhynchus in the Republic of Korea, using mosquito collection data, temperature, precipitation, elevation, land cover and the normalized difference vegetation index (NDVI). The resulting probability maps from the model were consistent with the known environmental limitations of the mosquito with low probabilities predicted for forest covered mountains. July minimum temperature and land cover were the most important variables in the model. Elevation, summer NDVI (July-September), precipitation in July, summer minimum temperature (May-August) and maximum temperature for fall and winter months also contributed to the model. Comparison of the Cx. tritaeniorhynchus model to the distribution of JE cases in the Republic of Korea from 2001 to 2009 showed that cases among a highly vaccinated Korean population were located in high-probability areas for Cx. tritaeniorhynchus. No recent JE cases were reported from the eastern coastline, where higher probabilities of mosquitoes were predicted, but where only small numbers of pigs are raised. The geographical distribution of reported JE cases corresponded closely with the predicted high-probability areas for Cx. tritaeniorhynchus, making the map a useful tool for health risk analysis that could be used for planning preventive public health measures. C1 [Masuoka, Penny; Achee, Nicole; Andre, Richard; Chamberlin, Judith; Grieco, John] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Klein, Terry A.; Yi, Suk H.] USA, Med Brigade 65, MEDDAC Korea, APO, AP 96205 USA. [Claborn, David M.] Missouri State Univ, Ctr Homeland Secur, Springfield, MO 65897 USA. [Small, Jennifer; Anyamba, Assaf] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA. [Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea. [Sardelis, Michael] Natl Ctr Med Intelligence, Ft Detrick, MD 21702 USA. [Kim, Heung-Chul] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, APO, AP 96205 USA. RP Masuoka, P (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM pmasuoka@usuhs.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center, Division of GEIS Operations FX The vector surveillance and modeling was funded by the Armed Forces Health Surveillance Center, Division of GEIS Operations. NR 26 TC 16 Z9 20 U1 0 U2 8 PU UNIV NAPLES FEDERICO II PI NAPLES PA FAC VET MED, DEP PATHOLOGY & ANIMAL HEALTH, VET PARASITOLOGY, VIA DELLA VETERINARIA 1, NAPLES, 80137, ITALY SN 1827-1987 J9 GEOSPATIAL HEALTH JI Geospatial Health PD NOV PY 2010 VL 5 IS 1 BP 45 EP 57 PG 13 WC Health Care Sciences & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 678OS UT WOS:000284089600005 PM 21080320 ER PT J AU Weiss, J Donigian, A Hughes, J AF Weiss, Jeff Donigian, Aram Hughes, Jonathan TI Extreme Negotiations SO HARVARD BUSINESS REVIEW LA English DT Article C1 [Weiss, Jeff] US Mil Acad, West Point, NY 10996 USA. [Donigian, Aram] USA, Negotiat Project, West Point, NY USA. RP Weiss, J (reprint author), US Mil Acad, West Point, NY 10996 USA. EM jweiss@vantagepartners.com; aram.donigian@usma.edu; jhughes@vantagepartners.com NR 0 TC 0 Z9 0 U1 2 U2 13 PU HARVARD BUSINESS SCHOOL PUBLISHING CORPORATION PI WATERTOWN PA 300 NORTH BEACON STREET, WATERTOWN, MA 02472 USA SN 0017-8012 J9 HARVARD BUS REV JI Harv. Bus. Rev. PD NOV PY 2010 VL 88 IS 11 BP 66 EP 75 PG 10 WC Business; Management SC Business & Economics GA 667PK UT WOS:000283205800033 PM 21049681 ER PT J AU Wu, JR Moser, DK Rayens, MK De Jong, MJ Chung, ML Riegel, B Lennie, TA AF Wu, Jia-Rong Moser, Debra K. Rayens, Mary Kay De Jong, Marla J. Chung, Misook L. Riegel, Barbara Lennie, Terry A. TI Rurality and event-free survival in patients with heart failure SO HEART & LUNG LA English DT Article ID QUALITY-OF-CARE; ELDERLY-PATIENTS; HEALTH-CARE; MYOCARDIAL-INFARCTION; DEPRESSION; OUTCOMES; DISEASE; MORTALITY; ADHERENCE; RISK AB BACKGROUND: Evidence of health disparities between urban and rural populations usually favors urban dwellers. The impact of rurality on heart failure (HF) outcomes is unknown. OBJECTIVE: We compared event-free survival between HF patients living in urban and rural areas. METHODS: In this longitudinal study, 136 patients with HF (male, 70%; age, mean +/- SD 61 +/- 11 years; New York Heart Association class III/IV, 60%) were enrolled. Patients' emergency department visits for HF exacerbation and rehospitalization during follow-up were identified. Rural status was determined by rural-urban commuting area code. Survival analysis was used to determine the effect of rurality on outcomes while controlling for relevant demographic, clinical, and psychosocial variables. RESULTS: Rural patients (64%) had longer event-free survival than urban patients (P = .015). Rurality (P = .04) predicted event-free survival after controlling for age, marital status, New York Heart Association class, medications, adherence to medications, depressive symptoms, and social support. CONCLUSIONS: Rural patients were less likely than their urban counterparts to experience an event. Further research is needed to identify protective factors that may be unique to rural settings. (Heart Lung (R) 2010;39:512-520.) C1 [Wu, Jia-Rong] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Moser, Debra K.; Rayens, Mary Kay; Chung, Misook L.; Lennie, Terry A.] Univ Kentucky, Coll Nursing, Lexington, KY USA. [De Jong, Marla J.] USA, Res & Mat Command, Blast Injury Res Program, Coordinating Off,Dept Def, Ft Detrick, MD USA. [Riegel, Barbara] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. RP Wu, JR (reprint author), Univ N Carolina, Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA. EM jiarongw@email.unc.edu FU Philips Medical-American Association of Critical Care Nurses Outcomes Grant; American Heart Association; University of Kentucky General Clinical Research Center [M01RR02602, R01 NR008567]; National Institute of Nursing Research, and Center [1P20NR010679]; National Institutes of Health (NIH); National Institute of Nursing Research FX This study was supported by a Philips Medical-American Association of Critical Care Nurses Outcomes Grant, an American Heart Association Great River Affiliate Post-doctoral Fellowship to J.-R.W., University of Kentucky General Clinical Research Center grant M01RR02602, grant R01 NR008567 from the National Institute of Nursing Research, and Center Grant 1P20NR010679 to the College of Nursing at the University of Kentucky from the National Institutes of Health (NIH) and National Institute of Nursing Research. The content of this article is solely the responsibility of the authors, and does not necessarily represent the official views of the National Institute of Nursing Research or the NIH. NR 41 TC 3 Z9 3 U1 2 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0147-9563 J9 HEART LUNG JI Heart Lung PD NOV-DEC PY 2010 VL 39 IS 6 BP 512 EP 520 DI 10.1016/j.hrtlng.2009.11.002 PG 9 WC Cardiac & Cardiovascular Systems; Nursing; Respiratory System SC Cardiovascular System & Cardiology; Nursing; Respiratory System GA 689JS UT WOS:000284924500010 PM 20561853 ER PT J AU Xu, JL Su, W Zhou, M AF Xu, Jefferson L. Su, Wei Zhou, MengChu TI Distributed Automatic Modulation Classification With Multiple Sensors SO IEEE SENSORS JOURNAL LA English DT Article DE Cognitive radio; distributed classification; distributed detection; likelihood ratio test (LRT); modulation classification; wireless sensor networks (WSN) ID DECENTRALIZED DETECTION; SNR ESTIMATION; SIGNAL; CHANNEL; NETWORKS; SYSTEMS; RADIO AB Automatic modulation classification (AMC) has been intensively studied to enhance the successful classification rate, particularly for overcoming the physical limit that deals with weak signals received in a noncooperative communication environment. A wireless sensor network (WSN) has multiple geometrically distributed sensors to work cooperatively. The distributed signal sensing and classification performed by collaborated sensors is proven to be beneficial to increasing the modulation classification reliability. In this paper, we apply the likelihood ratio-based distributed detection fusion technique to address the issues of general binary modulation classifications. The data fusion algorithm performed in the primary node is presented. Its numerical performance with simulation results is demonstrated. C1 [Xu, Jefferson L.; Zhou, MengChu] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. [Zhou, MengChu] Tongji Univ, Dept Comp Sci & Engn, Shanghai 201804, Peoples R China. [Su, Wei] USA, RDECOM, Commun Elect RD&E Ctr, Ft Monmouth, NJ 07703 USA. RP Xu, JL (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. EM lx26@njit.edu; Wei.Su@us.army.mil; zhou@njit.edu NR 26 TC 29 Z9 35 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD NOV PY 2010 VL 10 IS 11 BP 1779 EP 1785 DI 10.1109/JSEN.2010.2049487 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 668SV UT WOS:000283291000014 ER PT J AU Lin, JL Moore, JJ Sproul, WD Lee, SL Wang, J AF Lin, Jianliang Moore, John J. Sproul, William D. Lee, Sabrina L. Wang, Jun TI Effect of Negative Substrate Bias on the Structure and Properties of Ta Coatings Deposited Using Modulated Pulse Power Magnetron Sputtering SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE High power pulsed magnetron sputtering (HPPMS/HiPIMS); modulated pulse power (MPP); negative substrate bias; tantalum (Ta) coating; thick coating ID TANTALUM THIN-FILMS; PHYSICAL VAPOR-DEPOSITION; NITRIDE COATINGS; BETA-TANTALUM; SILICON; STEEL; DENSITIES; BEHAVIOR; ENERGY; COPPER AB Crystalline phase control is critical for obtaining desired structure and properties of Ta coatings deposited by magnetron sputtering. We have shown the approach to control the alpha and beta Ta phase formations by tuning the negative substrate bias voltage during modulated pulse power (MPP) magnetron sputtering, which generates a large fraction of target metallic ions in the plasma providing enhanced ion bombardment on the growing film. It was found that the peak and mean substrate ion current densities increased rapidly from 42 to 165 mAcm(-2) and 16 to 55 mAcm(-2), respectively, as the negative substrate bias voltage was increased from -20 to -50 V and became saturated with a further increase in the negative substrate bias voltage. As the negative substrate bias voltage was increased from 0 to -100 V, the MPP Ta phase changed from an all beta phase when the bias voltage was at 0 V and a floating bias, to a mixed alpha and beta phases when the bias voltage was in the range of -30 to -40 V, and finally to an all alpha phase when the negative bias voltage was -50 V or greater. In this paper, alpha Ta coating with thicknesses up to 100 mu m were successfully deposited using the MPP technique with high deposition rate. The residual stress of the thick Ta coating was measured using an X-ray stress analyzer. The adhesion strength of the thick Ta coating was evaluated using Rockwell-C indentation and scratch tests. The possibility to coat complex-shaped substrates with good coating coverage on the substrate's surface placed orthogonal to the target has also been demonstrated. C1 [Lin, Jianliang; Moore, John J.; Sproul, William D.; Wang, Jun] Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA. [Sproul, William D.] React Sputtering Inc, San Marcos, CA 92078 USA. [Lee, Sabrina L.] USA, Benet Labs, Watervliet Arsenal, NY 12189 USA. [Wang, Jun] HeFei Univ Technol, Dept Vacuum Technol & Proc Equipment, Hefei 230009, Peoples R China. RP Lin, JL (reprint author), Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA. EM jjmoore@mines.edu; bsproul@cox.net RI Lin, Jianliang/F-8405-2012 FU US Army [W15QKN-08-P-0528] FX This work was supported by the US Army under Army Award W15QKN-08-P-0528. NR 29 TC 21 Z9 23 U1 4 U2 37 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD NOV PY 2010 VL 38 IS 11 BP 3071 EP 3078 DI 10.1109/TPS.2010.2068316 PN 1 PG 8 WC Physics, Fluids & Plasmas SC Physics GA 678OP UT WOS:000284089300010 ER PT J AU Mahajan, B Berzofsky, JA Boykins, RA Majam, V Zheng, H Chattopadhyay, R de la Vega, P Moch, JK Haynes, JD Belyakov, IM Nakhasi, HL Kumar, S AF Mahajan, Babita Berzofsky, Jay A. Boykins, Robert A. Majam, Victoria Zheng, Hong Chattopadhyay, Rana de la Vega, Patricia Moch, J. Kathleen Haynes, J. David Belyakov, Igor M. Nakhasi, Hira L. Kumar, Sanjai TI Multiple Antigen Peptide Vaccines against Plasmodium falciparum Malaria SO INFECTION AND IMMUNITY LA English DT Article ID B-CELL EPITOPES; RED-BLOOD-CELLS; CIRCUMSPOROZOITE PROTEIN; T-CELL; SYNTHETIC PEPTIDES; SPOROZOITE VACCINE; IMMUNE-RESPONSE; SURFACE-ANTIGEN; ANTIBODIES; IMMUNOGENICITY AB The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antigenic epitopes from the sporozoite, liver, and blood stages of the life cycle. Antibody and cellular responses were determined in three inbred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice. All three MAPs were immunogenic and induced both antibody and cellular responses, albeit in a somewhat genetically restricted manner. Antibodies against MAP-1, MAP-2, and MAP-3 had an antiparasite effect that was also dependent on the mouse major histocompatibility complex background. Anti-MAP-1 (CSP-based) antibodies blocked the invasion of HepG2 liver cells by P. falciparum sporozoites (highest, 95.16% in HLA-A2 C57BL/6; lowest, 11.21% in BALB/c). Furthermore, antibodies generated following immunizations with the MAP-2 (PfCSP, PfLSA-1, PfMSP-1(42), and PfMSP-3b) and MAP-3 (PfRAP-1, PfRAP-2, PfSERA, and PfMSP-1(42)) vaccines were able to reduce the growth of blood stage parasites in erythrocyte cultures to various degrees. Thus, MAP-based vaccines remain a viable option to induce effective antibody and cellular responses. These results warrant further development and preclinical and clinical testing of the next generation of candidate MAP vaccines that are based on the conserved protective epitopes from Plasmodium antigens that are widely recognized by populations of divergent HLA types from around the world. C1 [Kumar, Sanjai] US FDA, Malaria Res Program, Div Emerging & Transfus Transmitted Dis, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA. [Berzofsky, Jay A.; Belyakov, Igor M.] NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [de la Vega, Patricia; Moch, J. Kathleen; Haynes, J. David] USN, Med Res Ctr, Silver Spring, MD USA. [de la Vega, Patricia; Moch, J. Kathleen; Haynes, J. David] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Kumar, S (reprint author), US FDA, Malaria Res Program, Div Emerging & Transfus Transmitted Dis, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA. EM Sanjai.kumar@fda.hhs.gov NR 63 TC 24 Z9 29 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 2010 VL 78 IS 11 BP 4613 EP 4624 DI 10.1128/IAI.00533-10 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 665RB UT WOS:000283052100018 PM 20823210 ER PT J AU Jain, R Yeo, H Chopra, I AF Jain, Robit Yeo, Hyeonsoo Chopra, Inderjit TI Examination of Rotor Loads due to On-Blade Active Controls for Performance Enhancement SO JOURNAL OF AIRCRAFT LA English DT Article ID AIRLOADS; HELICOPTER AB On-blade active controls with trailing-edge deflection, leading-edge deflection, and active-twist are studied for improvements in rotor aerodynamic efficiency and their influence on structural loads. A full-scale UH-60A Blackhawk rotor at two key flight conditions (high-speed forward flight and high-thrust forward flight) is studied using coupled computational fluid dynamics and computational structural dynamics simulations. A simulation-based trade study is carried out comprising parametric variations of geometric sizing and deployment schedules of the blade morphing. The study shows that active controls improve rotor performance and reduce rotor loads at the same time with careful selection of deployment schedule and design. In high-speed forward flight, using trailing-edge deflection, an improvement of 7.3% in performance and a reduction in the hub vibratory loads of up to 54% is achieved, and using active-twist an improvement of 7.0% in performance and up to 22% reduction in hub vibratory loads is achieved. In high-thrust forward flight, a 15.0% improvement in performance and up to 40% reduction in hub vibratory loads is achieved using leading-edge deflection. C1 [Jain, Robit] HyPerComp Inc, Westlake Village, CA 91361 USA. [Yeo, Hyeonsoo] NASA, Ames Res Ctr, Aeroflightdynam Directorate, US Army Res Dev & Engn Command, Moffett Field, CA 94035 USA. [Chopra, Inderjit] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. RP Jain, R (reprint author), HyPerComp Inc, Westlake Village, CA 91361 USA. EM rkj@hypercomp.net FU U.S. Army Research, Development, and Engineering Command under SBIR [W911W6-08-C-0061] FX This work is sponsored by U.S. Army Research, Development, and Engineering Command under SBIR Contract No. W911W6-08-C-0061. Technical monitors were Hyeonsoo Yeo and Mark Fulton at the U.S. Army Aeroflightdynamics Directorate. NR 29 TC 7 Z9 8 U1 0 U2 3 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD NOV-DEC PY 2010 VL 47 IS 6 BP 2049 EP 2066 DI 10.2514/1.C000306 PG 18 WC Engineering, Aerospace SC Engineering GA 695WV UT WOS:000285404200022 ER PT J AU Crossman, LC Chaudhuri, RR Beatson, SA Wells, TJ Desvaux, M Cunningham, AF Petty, NK Mahon, V Brinkley, C Hobman, JL Savarino, SJ Turner, SM Pallen, MJ Penn, CW Parkhill, J Turner, AK Johnson, TJ Thomson, NR Smith, SGJ Henderson, IR AF Crossman, Lisa C. Chaudhuri, Roy R. Beatson, Scott A. Wells, Timothy J. Desvaux, Mickael Cunningham, Adam F. Petty, Nicola K. Mahon, Vivienne Brinkley, Carl Hobman, Jon L. Savarino, Stephen J. Turner, Susan M. Pallen, Mark J. Penn, Charles W. Parkhill, Julian Turner, A. Keith Johnson, Timothy J. Thomson, Nicholas R. Smith, Stephen G. J. Henderson, Ian R. TI A Commensal Gone Bad: Complete Genome Sequence of the Prototypical Enterotoxigenic Escherichia coli Strain H10407 SO JOURNAL OF BACTERIOLOGY LA English DT Article ID EPITHELIAL-CELL INVASION; HEAT-LABILE ENTEROTOXIN; MOLECULAR CHARACTERIZATION; PLASMID STABILITY; GENE-CLUSTER; PROTEIN; IDENTIFICATION; SECRETION; COLONIZATION; VIRULENCE AB In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the complete genomic sequence of E. coli H10407, a prototypical strain of enterotoxigenic E. coli, which reproducibly elicits diarrhea in human volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains, revealing that the chromosome is closely related to that of the nonpathogenic commensal strain E. coli HS and to those of the laboratory strains E. coli K-12 and C. Furthermore, these analyses demonstrated that there were no chromosomally encoded factors unique to any sequenced ETEC strains. Comparison of the E. coli H10407 plasmids with those from several ETEC strains revealed that the plasmids had a mosaic structure but that several loci were conserved among ETEC strains. This study provides a genetic context for the vast amount of experimental and epidemiological data that have been published. C1 [Wells, Timothy J.; Desvaux, Mickael; Cunningham, Adam F.; Turner, Susan M.; Henderson, Ian R.] Univ Birmingham, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England. [Crossman, Lisa C.; Petty, Nicola K.; Parkhill, Julian; Turner, A. Keith; Thomson, Nicholas R.] Wellcome Trust Sanger Inst, Cambridge, England. [Chaudhuri, Roy R.] Univ Cambridge, Dept Vet Med, Cambridge, England. [Beatson, Scott A.] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia. [Pallen, Mark J.; Penn, Charles W.] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England. [Mahon, Vivienne; Smith, Stephen G. J.] Trinity Coll Dublin, Sch Med, Dept Clin Microbiol, Dublin, Ireland. [Brinkley, Carl] Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD USA. [Savarino, Stephen J.] Enter Dis Dept, Silver Spring, MD USA. [Hobman, Jon L.] Univ Nottingham, Sch Biosci, Loughborough, England. [Johnson, Timothy J.] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA. RP Henderson, IR (reprint author), Univ Birmingham, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England. EM i.r.henderson@bham.ac.uk RI DESVAUX, Mickael/A-8333-2008; Pallen, Mark/E-7619-2011; Parkhill, Julian/G-4703-2011; Petty, Nicola/A-3122-2012; Smith, Stephen/C-8523-2014; Beatson, Scott/B-6985-2013; Wells, Timothy/M-2025-2016; OI DESVAUX, Mickael/0000-0003-2986-6417; Pallen, Mark/0000-0003-1807-3657; Parkhill, Julian/0000-0002-7069-5958; Smith, Stephen/0000-0001-7807-2176; Beatson, Scott/0000-0002-1806-3283; Chaudhuri, Roy/0000-0001-5037-2695; Petty, Nicola/0000-0001-6528-9886; Wells, Timothy/0000-0001-7766-5404; Hobman, Jon/0000-0003-0998-9444 FU BBSRC [BB/C510075/1] FX This work was supported by project grant BB/C510075/1 from the BBSRC to I. R. H., M.J.P., C. W. P., J.P., and N.R.T. NR 66 TC 70 Z9 77 U1 0 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 EI 1098-5530 J9 J BACTERIOL JI J. Bacteriol. PD NOV PY 2010 VL 192 IS 21 BP 5822 EP 5831 DI 10.1128/JB.00710-10 PG 10 WC Microbiology SC Microbiology GA 662LD UT WOS:000282807900029 PM 20802035 ER PT J AU Khavrutskii, IV Wallqvist, A AF Khavrutskii, Ilja V. Wallqvist, Anders TI Computing Relative Free Energies of Solvation Using Single Reference Thermodynamic Integration Augmented with Hamiltonian Replica Exchange SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID ACCELERATED MOLECULAR-DYNAMICS; HYDRATION FREE-ENERGIES; BINDING FREE-ENERGIES; ROTATIONAL ISOMERIC STATES; HISTOGRAM ANALYSIS METHOD; MONTE-CARLO SIMULATIONS; AB-INITIO CALCULATIONS; CHARGE FORCE-FIELDS; CONFORMATIONAL FLEXIBILITY; EXPLICIT-SOLVENT AB This paper introduces an efficient single-topology variant of Thermodynamic Integration (TI) for computing relative transformation free energies in a series of molecules with respect to a single reference state. The presented TI variant that we refer to as Single-Reference TI (SR-TI) combines well-established molecular simulation methodologies into a practical computational tool. Augmented with Hamiltonian Replica Exchange (HREX), the SR-TI variant can deliver enhanced sampling in select degrees of freedom. The utility of the SR-TI variant is demonstrated in calculations of relative solvation free energies for a series of benzene derivatives with increasing complexity. Of note, the SR-TI variant with the HREX option provides converged results in a challenging case of an amide molecule with a high (13-15 kcal/mol) barrier for internal cis/trans interconversion using simulation times of only 1 to 4 ns. C1 [Khavrutskii, Ilja V.; Wallqvist, Anders] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Khavrutskii, IV (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM ikhavrutskii@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense under the High Performance Computing Software Applications Institutes (HSAI) initiative FX We would like to thank Dr. In-Chul Yeh, Dr. Michael S. Lee, and Dr. Hyung-June Woo for helpful discussions. Also, we acknowledge the National Cancer Institute (NCI) for allocation of computing time and staff support at the Advanced Biomedical Computing Center (ABCC) at NCI Frederick. This work was sponsored by the U.S. Department of Defense High Performance Computing Modernization Program (HPCMP), under the High Performance Computing Software Applications Institutes (HSAI) initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. NR 127 TC 13 Z9 13 U1 1 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD NOV PY 2010 VL 6 IS 11 SI 3285 BP 3427 EP 3441 DI 10.1021/ct1003302 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 676BE UT WOS:000283884300015 PM 21151738 ER PT J AU Huang, XZ Frye, JG Chahine, MA Cash, DM Barber, MG Babel, BS Kasper, MR Whitman, TJ Lindler, LE Bowden, RA Nikolich, MP AF Huang, Xiao-Zhe Frye, Jonathan G. Chahine, Mohamad A. Cash, Dana M. Barber, Melissa G. Babel, Britta S. Kasper, Matthew R. Whitman, Timothy J. Lindler, Luther E. Bowden, Robert A. Nikolich, Mikeljon P. TI Genotypic and Phenotypic Correlations of Multidrug-Resistant Acinetobacter baumannii-A. calcoaceticus Complex Strains Isolated from Patients at the National Naval Medical Center SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter ID ANTIMICROBIAL RESISTANCE; GENES; MICROARRAY; INTEGRONS C1 [Huang, Xiao-Zhe; Chahine, Mohamad A.; Cash, Dana M.; Bowden, Robert A.; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Frye, Jonathan G.] ARS, Bacterial Epidemiol & Antimicrobial Resistance Re, USDA, Athens, GA USA. [Babel, Britta S.; Kasper, Matthew R.; Whitman, Timothy J.] Natl Naval Med Ctr, Bethesda, MD USA. [Lindler, Luther E.] Dept Homeland Secur, Chem & Biol Div, Sci & Technol Directorate, Washington, DC USA. [Barber, Melissa G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Huang, XZ (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM xiaozhe.huang@amedd.army.mil RI Valle, Ruben/A-7512-2013; Frye, Jonathan/I-6382-2013 OI Frye, Jonathan/0000-0002-8500-3395 NR 9 TC 8 Z9 8 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2010 VL 48 IS 11 BP 4333 EP 4336 DI 10.1128/JCM.01585-10 PG 4 WC Microbiology SC Microbiology GA 672MK UT WOS:000283588500088 PM 20739490 ER PT J AU Bui-Mansfield, LT Clayton, TL AF Bui-Mansfield, Liem T. Clayton, Trevor L. TI Isolated Bone Infarct of the Calcaneus After Fracture SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE avascular necrosis; osteonecrosis; bone infarct; calcaneus; MR imaging; CT ID OSTEONECROSIS; NECROSIS; ADULT AB The calcaneus has a rich vascular supply; therefore, avascular necrosis of the calcaneus is extremely rare. We report the first case of bone infarct of the calcaneus 9 months after a fracture. We also review the literature on osteonecrosis of the calcaneus to offer potential mechanisms for bone infarction in the calcaneus after a fracture. C1 [Bui-Mansfield, Liem T.; Clayton, Trevor L.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.] USUHS, Dept Radiol, Bethesda, MD USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@gmail.com NR 9 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD NOV-DEC PY 2010 VL 34 IS 6 BP 958 EP 960 DI 10.1097/RCT.0b013e3181ddb956 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 681WA UT WOS:000284352800025 PM 21084916 ER PT J AU Barstow, C Gauer, R Jamieson, B AF Barstow, Craig Gauer, Robert Jamieson, Barbara TI How does electronic fetal heart rate monitoring affect labor and delivery outcomes? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material C1 [Barstow, Craig; Gauer, Robert] Womack Army Med Ctr, Family Med Residency Program, Ft Bragg, NC USA. [Jamieson, Barbara] Med Coll Wisconsin, Milwaukee, WI 53226 USA. RP Barstow, C (reprint author), Womack Army Med Ctr, Family Med Residency Program, Ft Bragg, NC USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD NOV PY 2010 VL 59 IS 11 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 797AY UT WOS:000293095800011 ER PT J AU Johnson, JB Ford, WM Rodrigue, JL Edwards, JW Johnson, CM AF Johnson, Joshua B. Ford, W. Mark Rodrigue, Jane L. Edwards, John W. Johnson, Catherine M. TI Roost Selection by Male Indiana Myotis Following Forest Fires in Central Appalachian Hardwoods Forests SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE Fernow Experimental Forest; forest fire; Indiana myotis; Myotis sodalis; prescribed fire; roost selection; West Virginia AB Despite the potential for prescribed fire and natural wildfire to increase snag abundance in hardwood forests, few studies have investigated effects of fire on bat roosting habitat, particularly that of the endangered Indiana myotis Myotis sodalis. From 2001 to 2009, we examined roost selection of Indiana myotis in burned and unburned forests in Tucker County, West Virginia. We radiotracked 15 male Indiana myotis to 50 roost trees; 16 in burned stands and 34 in unburned stands. Indiana myotis roosted in stands that had initially been burned 1-3 y prior to our observations. In burned stands, Indiana myotis roosted exclusively in fire-killed maples (Acer spp.). In unburned stands, they roosted in live trees, predominately hickories (Carya spp.), oaks (Quercus spp.), and maples. Roost trees in burned stands were surrounded by less basal area and by trees in advanced stages of decay, creating larger canopy gaps than at random trees in burned stands or actual roost trees located in unburned stands. Compared to random trees in unburned stands, roost trees in unburned stands were less decayed, had higher percent bark coverage, and were surrounded by less basal area, also resulting in larger canopy gaps. Roost-switching frequency and distances moved by Indiana myotis among roost trees were similar between burned and unburned stands. Our research indicates that use of fire for forest management purposes, at minimum provoked no response from Indiana myotis in terms of roost tree selection, and may create additional roost resources, depending on spatial context. C1 [Johnson, Joshua B.; Edwards, John W.] W Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. [Ford, W. Mark] USA, Engineer & Res Dev Ctr, Vicksburg, MS 39180 USA. [Rodrigue, Jane L.] US Forest Serv, No Res Stn, Parsons, WV 26287 USA. [Johnson, Catherine M.] US Forest Serv, Elkins, WV 26241 USA. RP Johnson, JB (reprint author), W Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. EM j-johnson3@juno.com FU U.S. Department of Agriculture Forest Service Northern Research Station [06-JV-11242300-140]; Florida Power and Light and BHE Environmental [06-CO-112331-034] FX The U.S. Department of Agriculture Forest Service Northern Research Station Joint Venture Agreement 06-JV-11242300-140 provided primary funding for our study from the National Fire Plan to West Virginia University, Division of Forestry and Natural Resources. Funding for prescribed burning was provided by a grant from Florida Power and Light and BHE Environmental to the U.S. Forest Service Northern Research Station through Collection Agreement 06-CO-112331-034. NR 60 TC 13 Z9 13 U1 5 U2 33 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD NOV PY 2010 VL 1 IS 2 BP 111 EP 121 DI 10.3996/042010-JFWM-007 PG 11 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA V26LH UT WOS:000208546600007 ER PT J AU Britzke, ER Slack, BA Armstrong, MP Loeb, SC AF Britzke, Eric R. Slack, Brooke A. Armstrong, Mike P. Loeb, Susan C. TI Effects of Orientation and Weatherproofing on the Detection of Bat Echolocation Calls SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE activity; Anabat; bats; orientation; weatherproofing AB Ultrasonic detectors are powerful tools for the study of bat ecology. Many options are available for deploying acoustic detectors including various weatherproofing designs and microphone orientations, but the impacts of these options on the quantity and quality of the bat calls that are recorded are unknown. We compared the impacts of three microphone orientations (horizontal, 45 degrees, and vertical) and two weatherproofing designs (polyvinyl chloride tubes and the BatHat) on the number of calls detected, call quality, and species detected by the Anabat II bat detector system at 17 sites in central Kentucky in May and June 2008. Detectors with BatHat weatherproofing recorded significantly fewer call sequences, pulses per file, species per site, and lower quality calls. Detectors in the horizontal position also tended to record fewer files, fewer species, and lower quality calls. These results illustrate potential impacts of deployment method on quality and quantity of data obtained. Because weatherproofing and orientation impacted the quality and quantity of data recorded, comparison of results using different methodologies should be made with caution. C1 [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Slack, Brooke A.] Kentucky Dept Fish & Wildlife Resources, Frankfort, KY 40601 USA. [Armstrong, Mike P.] US Fish & Wildlife Serv, Kentucky Ecol Serv Field Off, Frankfort, KY 40601 USA. [Loeb, Susan C.] US Forest Serv, So Res Stn, Clemson, SC 29634 USA. RP Britzke, ER (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM eric.r.britzke@usace.army.mil FU Kentucky Department of Fish and Wildlife Resources; U.S. Fish and Wildlife Service, Kentucky Ecological Service Field Office FX This study was supported by the Kentucky Department of Fish and Wildlife Resources and the U.S. Fish and Wildlife Service, Kentucky Ecological Service Field Office. NR 15 TC 13 Z9 15 U1 0 U2 23 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD NOV PY 2010 VL 1 IS 2 BP 136 EP 141 DI 10.3996/072010-JFWM-025 PG 6 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA V26LH UT WOS:000208546600010 ER PT J AU Eick, A Ticehurst, J Tobler, S Nevin, R Lindler, L Hu, Z MacIntosh, V Jarman, RG Gibbons, RV Myint, KSA Gaydos, J AF Eick, Angelia Ticehurst, John Tobler, Steven Nevin, Remington Lindler, Luther Hu, Zheng MacIntosh, Victor Jarman, Richard G. Gibbons, Robert V. Myint, Khin Saw Aye Gaydos, Joel TI Hepatitis E Seroprevalence and Seroconversion among US Military Service Members Deployed to Afghanistan SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID E VIRUS-INFECTION; ENTERICALLY-TRANSMITTED HEPATITIS; UNITED-STATES; BLOOD-DONORS; TRANSPLANT RECIPIENTS; KIDNEY-TRANSPLANT; OUTBREAK; DISEASE; PREVALENCE; PAKISTAN AB Background. Hepatitis E virus (HEV) has been recognized as a threat to military forces since its discovery. Although HEV seroprevalence in Afghanistan is not known, HEV infection is thought to be highly endemic in that country. This study determined the incidence of HEV seroconversion among United States (US) service members who were deployed to Afghanistan, as well as the prevalence of antibodies to HEV prior to the deployment. Methods. A random sample of 1500 subjects was selected from the cohort of service members who were deployed to Afghanistan between 2002 and 2006. Predeployment and postdeployment serum samples from these subjects were tested by enzyme immunoassay for total antibodies to HEV. Results. The seroprevalence of antibodies to HEV in US service members prior to deployment was 1.1%. The seroconversion rate among service members deployed to Afghanistan was 0.13%. Conclusions. Although subpopulations may be at higher risk for HEV exposure during deployment, the risk among US service members deployed to Afghanistan in this study was low. Previously implemented and current preventive measures in theater appear to have been adequate. With future deployments to new areas or changes in military operations in areas of risk, continued surveillance for HEV infection in the military will be warranted. C1 [Eick, Angelia; Tobler, Steven; Nevin, Remington; Lindler, Luther; Hu, Zheng; MacIntosh, Victor; Gaydos, Joel] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Ticehurst, John] Johns Hopkins Univ, Appl Phys Lab, Natl Secur Technol Dept, Laurel, MD USA. [Ticehurst, John] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Ticehurst, John] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Jarman, Richard G.; Gibbons, Robert V.; Myint, Khin Saw Aye] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Eick, A (reprint author), USAF, Hlth Surveillance Ctr, 2900 Linden Ln,Ste 200, Silver Spring, MD 20910 USA. EM angie.eick@us.army.mil RI Ticehurst, John/I-7532-2012; Valle, Ruben/A-7512-2013; OI Nevin, Remington/0000-0002-0534-1889 FU Department of Defense Global Emerging Infections Surveillance and Response [GM0072_07_CH] FX Department of Defense Global Emerging Infections Surveillance and Response (award GM0072_07_CH to A.E.). NR 50 TC 13 Z9 13 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 1 PY 2010 VL 202 IS 9 BP 1302 EP 1308 DI 10.1086/656598 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 656VB UT WOS:000282367900003 PM 20863230 ER PT J AU Rushing, JF Newman, K AF Rushing, John F. Newman, Kent TI Investigation of Laboratory Procedure for Evaluating Chemical Dust Palliative Performance SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Dust; Full-scale tests; Military engineering; Unpaved roads; Soil stabilization; Airfields AB An experimental testing protocol was developed to compare the relative effectiveness of chemical dust palliatives. The methods and application simulate field construction using commercial spray components. The test devices were constructed to simulate wind speeds and conditions for rotary wing aircraft. Fifteen chemical dust suppressants were evaluated using this methodology. These commercial products were applied topically to prepared soil specimens and allowed to cure for one and 48 h. Effectiveness was determined from the relative mass loss of the soil samples from erosion when samples were subjected to an air impingement device. An optical dust sensor was installed in the test device to measure airborne dust concentrations as an additional method for quantifying performance. A method to disturb the treated soil surface was also introduced to simulate the effect of traffic. Select application rates of the palliatives were used in sample preparation to identify minimal quantities necessary for the desired performance. The testing equipment and processes provided a rapid screening methodology for selecting potential dust palliatives. Results indicated good correlation between erosion and airborne dust concentrations with higher application rates and complete curing of materials demonstrating reduced dust levels. The traffic simulation test identified products with a propensity to form surface crusts that may be disturbed by traffic. C1 [Rushing, John F.; Newman, Kent] USA, Airfields & Pavements Branch, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rushing, JF (reprint author), USA, Airfields & Pavements Branch, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM john.f.rushing@usace.army.mil; john.k.newman@usace.army.mil NR 7 TC 0 Z9 0 U1 2 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD NOV PY 2010 VL 22 IS 11 BP 1148 EP 1155 DI 10.1061/(ASCE)MT.1943-5533.0000122 PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 667JA UT WOS:000283187900008 ER PT J AU Russell, K Shen, Q AF Russell, Kevin Shen, Qiong TI A General Static Torque Constraint for Spatial Four-Bar Motion Generation With a Coupler Load SO JOURNAL OF MECHANISMS AND ROBOTICS-TRANSACTIONS OF THE ASME LA English DT Article ID MULTIPLY SEPARATED POSITIONS; KINEMATIC SYNTHESIS; MECHANISMS; FINITE AB A general static torque constraint for spatial four-bar mechanisms with coupler forces is formulated in this work. With this constraint, the user can synthesize spatial four-bar motion generators that also support static coupler loads. This constraint is demonstrated in the synthesis of RRSS, SSRC, and 4R spherical motion generators to approximate prescribed coupler poses and do so within maximum specified driver torques for given coupler forces. [DOI:10.1115/1.4002514] C1 [Russell, Kevin] USA, Res Dev & Engn Ctr, Armament Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Shen, Qiong] ASCO Power Technol, Power Control Syst Engn, Florham Pk, NJ 07932 USA. RP Russell, K (reprint author), USA, Res Dev & Engn Ctr, Armament Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil; john.shen@emerson.com NR 12 TC 1 Z9 1 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1942-4302 J9 J MECH ROBOT JI J. Mech. Robot. PD NOV PY 2010 VL 2 IS 4 AR 044502 DI 10.1115/1.4002514 PG 6 WC Engineering, Mechanical; Robotics SC Engineering; Robotics GA 782GX UT WOS:000291997600015 ER PT J AU Kim, HC Chong, ST Chae, JS Lee, H Klein, TA Suh, SJ Rueda, LM AF Kim, Heung Chul Chong, Sung Tae Chae, Joon-Seok Lee, Hang Klein, Terry A. Suh, Sang Jae Rueda, Leopoldo M. TI New Record of Lipoptena cervi and Updated Checklist of the Louse Flies (Diptera: Hippoboscidae) of the Republic of Korea SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE louse fly; Lipoptena cervi; Hippoboscidae; water deer; Korea ID BARTONELLA-SCHOENBUCHENSIS; DEER AB This is the first confirmed record of the genus Lipoptena Nitzsch and its species, Limptena cervi (Linnaeus), from the Republic of Korea. A total of five females and 10 males was collected from eight of 29 Korean water deer, Hydropotes inermis at-gilt-opus Swinhoe, from Cangwon and Gyeongsangbuk Provinces and Ulsan Metropolitan Area from May through October 2008. An updated checklist of Korean hippoboscids contains nine species in six genera (Hippobosca Linnaeus, lcosta Speiser, Lipoptena, Ornithoctona Speiser, Ornithomya Lattreille, and Ornithophila Rondani). Hosts, collection records, and repositories are also noted. C1 [Suh, Sang Jae] Kyungpook Natl Univ, Coll Life Sci & Nat Resources, Dept Environm Hort, Sangju 742711, South Korea. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Unit 15281, APO, AP 96205 USA. [Lee, Hang] Seoul Natl Univ, Coll Vet Med, Conservat Genome Resource Bank Korean Wildlife, Seoul 151742, South Korea. [Chae, Joon-Seok] Seoul Natl Univ, Coll Vet Med, Program Vet Sci BK21, Seoul 151742, South Korea. [Chae, Joon-Seok] Seoul Natl Univ, Coll Vet Med, Res Inst Vet Sci, Seoul 151742, South Korea. [Kim, Heung Chul; Chong, Sung Tae] Unit 15247, APO, AP 96205 USA. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Lee, Hang/A-7516-2011; Valle, Ruben/A-7512-2013 OI Lee, Hang/0000-0003-0264-6289; FU Conservation Genome Resource Bank for Korean Wildlife, Seoul National University; Korean Government [2009-0071622]; Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems (Silver Spring, MD); National Center for Military Intelligence (Fort Detrick, MD) FX We thank Captain Peter V. Nunn, 5th Medical Detachment, 168th Medical Battalion, 65th Medical Brigade, and the Conservation Genome Resource Bank for Korean Wildlife, Seoul National University, for their support in this work. We also thank Jun-Cu Kang and Sungjin Ko, College of Veterinary Medicine, Seoul National University, for collection of deer keds in this survey; and Richard Robbins, Armed Forces Pest Management Board, and Joel Gaydos, Armed Forces Health Surveillance Center for their support in conducting this work. Special thanks go to F. C. Thompson for confirming the identification of the specimens, and to D. M. Levin and B. P. Rueda for reviewing the manuscript and providing helpful suggestions. Portions of this work were supported by National Research Foundation of Korea grant funded by the Korean Government (2009-0071622), the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems (Silver Spring, MD), and the National Center for Military Intelligence (Fort Detrick, MD). NR 12 TC 6 Z9 6 U1 0 U2 3 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2010 VL 47 IS 6 BP 1227 EP 1230 DI 10.1603/ME09262 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 684RR UT WOS:000284567500035 PM 21175076 ER PT J AU Burke, RL Barrera, R Kluchinsky, T Lewis, M Claborn, DM AF Burke, R. L. Barrera, R. Kluchinsky, T. Lewis, M. Claborn, D. M. TI Examination of a Miniaturized Funnel Trap for Aedes aegypti (Diptera: Culicidae) Larval Sampling SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; septic tanks; funnel trap ID SEPTIC TANKS; WELLS; MOSQUITOS; COPEPODS AB Funnel traps are often used to sample for the presence of Aedes aegypti (L.) (Diptera: Gulicidae) larvae in subterranean aquatic habitats. These traps are generally >= 15 cm in diameter, making them impractical for use in subterranean sites that have narrow (10-cm) access ports, such as those in standard-sized septic tanks. Recent research indicates septic tanks may be important habitats for Ac. aegypti in Puerto Rico and the Caribbean. To sample mosquito larval populations in these sites, a miniaturized funnel trap was necessary. This project describes the use of a smaller funnel trap for sampling larval populations. The effects of larval instar (third and fourth) and population density on trap efficacy also are examined. The trap detected larval presence 83% of the time at a larval density of 0.011 larvae per cm(2) and 100% of the time at densities >= 0.022 larvae per cm(2). There was a significant trend of increasing percentage of recaptured larvae with higher larval population densities. Although the miniaturized funnel trap is less sensitive at detecting larval presence in low population densities, it may be useful for sampling aquatic environments with restricted access or shallow water, particularly in domestic septic tanks. C1 [Barrera, R.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. [Kluchinsky, T.] USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA. [Kluchinsky, T.; Lewis, M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Claborn, D. M.] Missouri State Univ, MPH Program, Springfield, MO 65897 USA. [Burke, R. L.] Armed Forces Hlth Surveillance Ctr, Div Global Emerging Infect Surveillance & Respons, Silver Spring, MD 20910 USA. RP Burke, RL (reprint author), Armed Forces Hlth Surveillance Ctr, Div Global Emerging Infect Surveillance & Respons, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ronald.burke@us.army.mil FU USU FX We acknowledge Cara Olsen (Uniformed Services University [USU]) for assistance with the statistics and Edward Mitre (USU) for guidance and direction. We also thank Brian Kay and Yen Nguyen for information on funnel trap designs. Funding for this project was provided by the USU Intramural fund for graduate students. NR 12 TC 1 Z9 1 U1 0 U2 5 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2010 VL 47 IS 6 BP 1231 EP 1234 DI 10.1603/ME10112 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 684RR UT WOS:000284567500036 PM 21175077 ER PT J AU West, BJ Clancy, TR AF West, Bruce J. Clancy, Thomas R. TI Flash Crashes, Bursts, and Black Swans Parallels Between Financial Markets and Healthcare Systems SO JOURNAL OF NURSING ADMINISTRATION LA English DT Article AB As systems evolve over time, their natural tendency is to become increasingly more complex. Studies in the field of complex systems have generated new perspectives on management in social organizations such as hospitals. Much of this research appears as a natural extension of the cross-disciplinary field of systems theory. This is the 16th in a series of articles applying complex systems science to the traditional management concepts of planning, organizing, directing, coordinating, and controlling. In this article, Dr Clancy, the editor of this column, and coauthor, Dr West, discuss how the collapse of global financial markets in 2008 may provide valuable insight into mechanisms of complex system behavior in healthcare. Dr West, a physicist and expert in the field of complex systems and network science, is author of a chapter in the book, On the Edge: Nursing in the Age of Complexity (Lindberg C, Nash S, Linberg C. Bordertown, NJ: Plexus Press; 2008) and his most recent book, Disrupted Networks: From Physics to Climate Change (West BJ, Scafetta N. Singapore: Disrupted Networks, World Scientific Publishing; 2010). C1 [Clancy, Thomas R.] Univ Minnesota, Sch Nursing, Minneapolis, MN 55455 USA. [West, Bruce J.] USA, Res Off, Math & Informat Directorate, Res Triangle Pk, NC 27709 USA. RP Clancy, TR (reprint author), Univ Minnesota, Sch Nursing, Weaver Densford Hall,308 Harvard Ave S, Minneapolis, MN 55455 USA. EM clanc027@umn.edu NR 3 TC 7 Z9 7 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-0443 J9 J NURS ADMIN JI J. Nurs. Adm. PD NOV PY 2010 VL 40 IS 11 BP 456 EP 459 DI 10.1097/NNA.0b013e3181f88a8b PG 4 WC Nursing SC Nursing GA 671TZ UT WOS:000283535200003 PM 20978411 ER PT J AU Hannah, ST Avolio, BJ AF Hannah, Sean T. Avolio, Bruce J. TI Ready or not: How do we accelerate the developmental readiness of leaders? SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article ID PERSONALITY AB A theory of leader developmental readiness is examined comprised of leaders' motivation and ability to develop Early theory building and testing suggests leaders' motivation to develop is promoted through interest and goals learning goal orientation and developmental efficacy, while leaders ability to develop is promoted through self awareness self complexity, and meta-cognitive ability Copyright (C) 2010 John Wiley & Sons Ltd C1 [Hannah, Sean T.] US Mil Acad, Army Ctr Excellence Profess Mil Eth, West Point, NY 10996 USA. [Avolio, Bruce J.] Univ Washington, Dept Management & Org, Seattle, WA 98195 USA. RP Hannah, ST (reprint author), US Mil Acad, Army Ctr Excellence Profess Mil Eth, 646 Swift Rd, West Point, NY 10996 USA. NR 15 TC 21 Z9 21 U1 0 U2 13 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0894-3796 J9 J ORGAN BEHAV JI J. Organ. Behav. PD NOV PY 2010 VL 31 IS 8 BP 1181 EP 1187 DI 10.1002/job.675 PG 7 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 694CD UT WOS:000285271700006 ER PT J AU Burns, TC Stinner, DJ Possley, DR Mack, AW Eckel, TT Potter, BK Wenke, JC Hsu, JR AF Burns, Travis C. Stinner, Daniel J. Possley, Daniel R. Mack, Andrew W. Eckel, Tobin T. Potter, Benjamin K. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Consortium ST TI Does the Zone of Injury in Combat-Related Type III Open Tibia Fractures Preclude the Use of Local Soft Tissue Coverage? SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE open; tibia; fracture; flap; rotational ID DONOR-SITE MORBIDITY; OPERATION ENDURING FREEDOM; LOWER-EXTREMITY; MUSCLE-FLAP; IRAQI FREEDOM; MANAGEMENT; RECONSTRUCTION; EXPERIENCE; CLASSIFICATION; COMPLICATIONS AB Objectives: Does the large zone of injury in high-energy, combat-related open tibia fractures limit the effectiveness of rotational flap coverage? Design: Retrospective consecutive series. Setting: This study was conducted at Brooke Army Medical Center, Walter Reed Army Medical Center, and National Naval Medical Center between March 2003 and September 2007. Patients/Participants: We identified 67 extremities requiring a coverage procedure out of 213 consecutive combat-related Type III open diaphyseal tibia fractures. Intervention: The 67 Type III B tibia fractures were treated with rotational or free flap coverage. Main Outcome Measures: Flap failure, reoperation, infection, amputation, time to union, and visual pain scale. Results: There were no differences between the free and rotational flap cohorts with respect to demographic information, injury characteristics, or treatment before coverage. The reoperation and amputation rates were significantly lower for the rotational coverage group (30% and 9%) compared with the free flap group (64% and 36%; P = 0.05 and P = 0.03, respectively). The coverage failure rate was also lower for the rotational flap cohort (7% versus 27%, P = 0.08). The average time to fracture union for the free flap group was 9.5 months (range, 5-15.8 months) and 10.5 months (range, 3-41 months) for the rotational flap group (P = 0.99). Conclusions: There was a significantly lower amputation and reoperation rate for patients treated with rotational coverage. Contrary to our hypothesis and previous reports, the zone of injury in combat-related open tibia fractures does not preclude the use of local rotational coverage when practicable. C1 [Burns, Travis C.; Stinner, Daniel J.; Possley, Daniel R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Mack, Andrew W.; Eckel, Tobin T.; Potter, Benjamin K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Burns, TC (reprint author), Brooke Army Med Ctr, Bldg 3600,3851 Roger Brook Dr, Ft Sam Houston, TX 78234 USA. EM Travis.Burns@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262; Potter, MD, Benjamin K./0000-0002-8771-0317 NR 45 TC 14 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD NOV PY 2010 VL 24 IS 11 BP 697 EP 703 DI 10.1097/BOT.0b013e3181d048b8 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 664MU UT WOS:000282966300012 PM 20926962 ER PT J AU Lewis, JA Dennis, WE Hadix, J Jackson, DA AF Lewis, John A. Dennis, William E. Hadix, Jennifer Jackson, David A. TI Analysis of Secreted Proteins as an in vitro Model for Discovery of Liver Toxicity Markers SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE ethanol exposure; HepG2/C3A; human biomarkers; liver toxicity markers; quantitative proteomics ID PRIMARY HUMAN HEPATOCYTES; IGF-BINDING PROTEIN-1; HEPG2 CELLS; HEPATIC-FIBROSIS; ENZYME LEVELS; INDUCTION; EXPRESSION; DISEASE; HEPATOTOXICITY; INTERLEUKIN-6 AB Despite the wealth of sequence data and new technologies that can scan large portions of the transcriptome or proteome in a single experiment, attempts to identify human biomarkers of toxicity have been met with limited success. We have adapted an in vitro model system to identify proteins secreted by a human hepatoma-derived cell line (HepG2/C3A) in response to toxicant exposure. Using quantitative proteomics, we can find alterations in the abundance of proteins at the source of damage liver cells that are likely to be present in blood samples of exposed animals. In a proof of concept experiment, conditioned medium from cells exposed to ethanol was subjected to quantitative mass spectral analysis after abundant proteins were immunodepleted. Eighty-seven proteins were identified with almost half changing in abundance. Some of these were only identified in the highest treatment condition and presumably result from the release of intracellular proteins into the medium when the cell membrane is disrupted upon cell death. However, the majority of the identified proteins reflect known consequences of ethanol exposure or alcoholism. The analysis of proteins found in conditioned medium after exposure to toxicants appears to be a useful system for the expedited discovery of potential human biomarkers. C1 [Lewis, John A.; Dennis, William E.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [Hadix, Jennifer] SAIC Inc, Ft Detrick, MD 21702 USA. RP Lewis, JA (reprint author), USA, Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM john.a.lewis1@us.army.mil RI Jackson, David/E-9984-2014 FU U.S. Army Medical Research and Materiel Command FX Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The research was sponsored by the U.S. Army Medical Research and Materiel Command, Military Operational Medicine Research Program. Citations of commercial organizations or trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The authors wish to thank Dr. Naissan Hussainzada and Dr. James Dillman for critical review of the manuscript. NR 36 TC 10 Z9 11 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 J9 J PROTEOME RES JI J. Proteome Res. PD NOV PY 2010 VL 9 IS 11 BP 5794 EP 5802 DI 10.1021/pr1005668 PG 9 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 675FA UT WOS:000283810500028 PM 20822094 ER PT J AU Macdonald, B AF Macdonald, Brian TI Density of Complex Critical Points of a Real Random SO(m+1) Polynomial SO JOURNAL OF STATISTICAL PHYSICS LA English DT Article DE Random polynomials; Several complex variables; Random critical points; Random zeros ID EXACT STATISTICS; ZEROS; UNIVERSALITY; ROOTS AB We study the density of complex critical points of a real random SO(m+1) polynomial in m variables. In a previous paper (Macdonald in J. Stat. Phys. 136(5):807, 2009), the author used the Poincar,-Lelong formula to show that the density of complex zeros of a system of these real random polynomials rapidly approaches the density of complex zeros of a system of the corresponding complex random polynomials, the SU(m+1) polynomials. In this paper, we use the Kac-Rice formula to prove an analogous result: the density of complex critical points of one of these real random polynomials rapidly approaches the density of complex critical points of the corresponding complex random polynomial. In one variable, we give an exact formula and a scaling limit formula for the density of critical points of the real random SO(2) polynomial as well as for the density of critical points of the corresponding complex random SU(2) polynomial. C1 [Macdonald, Brian] Johns Hopkins Univ, Dept Math, Baltimore, MD 21218 USA. RP Macdonald, B (reprint author), US Mil Acad, MADN MATH, 646 Swift Rd, West Point, NY 10996 USA. EM bmac@jhu.edu NR 14 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-4715 J9 J STAT PHYS JI J. Stat. Phys. PD NOV PY 2010 VL 141 IS 3 BP 517 EP 531 DI 10.1007/s10955-010-0057-y PG 15 WC Physics, Mathematical SC Physics GA 664QC UT WOS:000282976100005 ER PT J AU Esquivel, J Chua, TC Stojadinovic, A Melero, JT Levine, EA Gutman, M Howard, R Piso, P Nissan, A Gomez-Portilla, A Gonzalez-Bayon, L Gonzalez-Moreno, S Shen, P Stewart, JH Sugarbaker, PH Barone, RM Hoefer, R Morris, DL Sardi, A Sticca, RP AF Esquivel, J. Chua, T. C. Stojadinovic, A. Torres Melero, J. Levine, E. A. Gutman, M. Howard, R. Piso, P. Nissan, A. Gomez-Portilla, A. Gonzalez-Bayon, L. Gonzalez-Moreno, S. Shen, P. Stewart, J. H. Sugarbaker, P. H. Barone, R. M. Hoefer, R. Morris, D. L. Sardi, A. Sticca, R. P. TI Accuracy and Clinical Relevance of Computed Tomography Scan Interpretation of Peritoneal Cancer Index in Colorectal Cancer Peritoneal Carcinomatosis: A Multi-Institutional Study SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE colorectal cancer; computed tomography; peritoneal carcinomatosis ID HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; OVARIAN-CANCER; SURFACE MALIGNANCIES; CONSENSUS STATEMENT; PROGNOSTIC-FACTORS; CT; MANAGEMENT; ORIGIN AB Background: Evaluation of peritoneal metastases by computed tomography (CT) scans is challenging and has been reported to be inaccurate. Methods: A multi-institutional prospective observational registry study of patients with peritoneal carcinomatosis from colorectal cancer was conducted and a subset analysis was performed to examine peritoneal cancer index (PCI) based on CT and intraoperative exploration. Results: Fifty-two patients (mean age 52.6 +/- 12.4 years) from 16 institutions were included in this study Inaccuracies of CT-based assessment of lesion sizes were observed in the RUQ (P = 0 004). LLQ (P < 0.0005). RLQ (P = 0.003), distal jejunum (P = 0004), and distal ileum (P < 0.0005). When CT-PCI was classified based on the extent of carcinomatosis, 17 cases (33%) were underestimations, of which, 11 cases (21%) were upstaged from low to moderate, 4 cases (8%) were upstaged from low to severe, and 2 cases (4%) were upstaged from moderate to severe. Relevant clinical discordance where an upstage occurred to severe carcinomatosis constituted a true inaccuracy and was observed in six cases (12%). Conclusions: The actual clinical impact of inaccuracies of CT-PCI was modest. CT-PCI will remain as a mandatory imaging tool and may be supplemented with other tools including positron emission tomography scan or diagnostic laparoscopy, in the patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy J. Surg Oncol. 2010;102:565-570. (C) 2010 Wiley-Liss, Inc. C1 [Esquivel, J.] St Agnes Hosp, Dept Surg Oncol, Baltimore, MD 21229 USA. [Chua, T. C.; Morris, D. L.] Univ New S Wales, St George Hosp, Sydney, NSW, Australia. [Stojadinovic, A.; Howard, R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Torres Melero, J.] Hosp Torrecardenas, Almeria, Spain. [Levine, E. A.; Shen, P.; Stewart, J. H.] Wake Forest Univ, Baptist Med Ctr, Winston Salem, NC 27109 USA. [Gutman, M.] Meir Hosp, Sapit Med Ctr, Kefar Sava, Israel. [Piso, P.] Univ Regensburg, Med Ctr, Regensburg, Germany. [Nissan, A.] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel. [Gomez-Portilla, A.] Hosp Santiago Apostol, Vitoria, Spain. [Gonzalez-Bayon, L.] Hosp Gen Univ Gregorio Maranon, Madrid, Spain. [Gonzalez-Moreno, S.] Ctr Oncol MD Anderson Int Espana, Madrid, Spain. [Sugarbaker, P. H.] Washington Hosp Ctr, Washington, DC 20010 USA. [Barone, R. M.] Sharp Mem Hosp & Rehabil Ctr, San Diego, CA USA. [Hoefer, R.] Surg Oncol Associates, Newport News, VA USA. [Sardi, A.] St Johns Mercy Med Ctr, Baltimore, MD USA. [Sticca, R. P.] Univ N Dakota, Altru Hosp, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA. RP Esquivel, J (reprint author), St Agnes Hosp, Dept Surg Oncol, 900 Caton Ave, Baltimore, MD 21229 USA. FU NCI NIH HHS [K08 CA131482] NR 21 TC 52 Z9 54 U1 0 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD NOV 1 PY 2010 VL 102 IS 6 BP 565 EP 570 DI 10.1002/jso.21601 PG 6 WC Oncology; Surgery SC Oncology; Surgery GA 674OZ UT WOS:000283758300006 PM 20976729 ER PT J AU Johnson, D Gegel, B Burgert, J Duncklee, GW Robison, RR Lewis, EJ Crum, PM Kuhns, W Moore, D O'Brien, S Elliott, J Washington, J Boyle, J Seigler, D AF Johnson, Don Gegel, Brian Burgert, James Duncklee, Geoffrey W. Robison, Ricci R. Lewis, Eric J. Crum, Paul M. Kuhns, William Moore, Daniel O'Brien, Scott Elliott, Joel Washington, Jason Boyle, John Seigler, Dale TI Effects of the HEET Garment in the Prevention of Hypothermia in a Porcine Model SO JOURNAL OF SURGICAL RESEARCH LA English DT Review DE hypothermia; aeromedic evacuation; combat care; hypothermic prevention ID COMBAT; EXPERIENCE; CARE AB Background. Hypothermia is a common battlefield trauma occurrence. This study compared the effectiveness of the hypothermia, environmental, exposure, and trauma (HEET) garment (Trident Industries, Beaufort, SC) with and without thermal inserts with a control group of two wool blankets in the prevention of hypothermia in a treated hypovolemic porcine model. Materials and methods. Five female swine (Sus scrofa-Yorkshire cross) were assigned to each of three groups: HEET with thermal inserts (n = 5); HEET without thermal inserts (n = 5); or control (n = 5). After the animals were anesthetized and stabilized for 30min, the swine were hemorrhaged to a mean arterial pressure (MAP) of 30min Hg, simulating a battlefield injury. Hetastarch 6% (500mL) was rapidly administered, simulating initial field resuscitation. One hour later, the animals' shed blood was reinfused, simulating transfusion at a field medical facility. The investigators moved the animal into a cooler set at 10 degrees C +/- 0.5 degrees C. A pulmonary artery catheter was used to monitor core body temperature over a 6-h period. Results. A repeated measures ANOVA and Tukey's post hoc test were used to analyze the data. There was a significant difference between the groups. At the end of 6h, the mean core temperature for the BEET with inserts group was 32.69 degrees C +/- 1.5; the HEET without inserts, 31.02 degrees C +/- 1.8; and control, 34.78 degrees C +/- 1.2 (P <0.05). While all groups became hypothermic, the wool blanket group was most effective in maintaining body temperature closer to normothermia. Conclusion. The HEET garments with and without heaters are ineffective in preventing hypothermia. Published by Elsevier Inc. C1 [Johnson, Don; Duncklee, Geoffrey W.; Robison, Ricci R.; Lewis, Eric J.; Crum, Paul M.; Kuhns, William; Moore, Daniel; O'Brien, Scott; Elliott, Joel; Washington, Jason; Boyle, John; Seigler, Dale] USA, Grad Program Anesthesia, Ft Sam Houston, TX USA. [Gegel, Brian; Burgert, James] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Johnson, D (reprint author), USA, Grad Program Anesthesia, 7627 Lynn Ann, San Antonio, TX 78240 USA. EM Arthur.johnson@amedd.army.mil OI Burgert, James/0000-0001-8346-6196 NR 12 TC 1 Z9 1 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD NOV PY 2010 VL 164 IS 1 BP 126 EP 130 DI 10.1016/j.jss.2009.07.038 PG 5 WC Surgery SC Surgery GA 672XX UT WOS:000283622100022 PM 20060130 ER PT J AU Gegel, B Burgert, J Cooley, B MacGregor, J Myers, J Calder, S Luellen, R Loughren, M Johnson, D AF Gegel, Brian Burgert, James Cooley, Brian MacGregor, Jacob Myers, Jules Calder, Sean Luellen, Ralph Loughren, Michael Johnson, Don TI The Effects of BleedArrest, Celox, and TraumaDex on Hemorrhage Control in a Porcine Model SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE hemorrhage; hemorrhage control; hemostatic agents ID EXTREMITY ARTERIAL HEMORRHAGE; HEMOSTATIC AGENT QUIKCLOT; LETHAL GROIN INJURY; BLOOD-LOSS; VENOUS HEMORRHAGE; HEPATIC-INJURY; ANIMAL-MODEL; LIVER-INJURY; SWINE MODEL; DRESSINGS AB Background. Hemorrhage is the second leading cause of death in civilian trauma and the leading cause of preventable death in military trauma. The purpose of this study was to examine the effectiveness of three hemostatic agents: BleedArrest, TraumaDex, and Celox. Materials and Methods. This was a prospective, experimental study using male Yorkshire swine. The pigs (n = 5 per group) were randomly assigned to one of the following: BleedArrest, TraumaDex, Celox, or control. To simulate a trauma injury, the investigators generated a complex groin injury with transection of the femoral artery and vein in all pigs. After 1 min of uncontrolled hemorrhage, one of the hemostatic agents was poured into the wound, followed by standard wound packing. The control group underwent the same procedures with the exception of the hemostatic agents. In all groups, 5 min of direct manual pressure was applied to the wound followed by a standard pressure dressing. After 30 min, dressings were removed, and the amount of bleeding was determined. Results. There were significant differences between the BleedArrest(mean = 21.2, SD +/- 36.6 mL) TraumaDex (mean = 68, SD +/- 103.5 mL) and Celox (mean = 18.16, SD +/- 41.6 mL) groups compared with Control group (mean = 230, SD +/- 154 mL) (P < 0.05). However, there were no statistically significant difference between BleedArrest, TraumaDex, and Celox groups (P = 0.478). Conclusions. BleedArrest, Celox, and TraumaDex were statistically and clinically superior at controlling hemorrhage compared with the standard pressure dressing in the control group. Published by Elsevier Inc. C1 [Gegel, Brian] USA, Grad Program Anesthesia, Brooke Army Med Ctr, Houston, TX USA. [Cooley, Brian; MacGregor, Jacob; Myers, Jules; Calder, Sean; Luellen, Ralph; Loughren, Michael; Johnson, Don] USA, Grad Program Anesthesia Nursing, Ft Sam Houston, TX USA. RP Johnson, D (reprint author), Acad Hlth Sci, Dept Army, 3490 Forage Rd, Ft Sam Houston, TX 78234 USA. EM Arthur.johnson@amedd.army.mil OI Burgert, James/0000-0001-8346-6196 NR 37 TC 2 Z9 3 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD NOV PY 2010 VL 164 IS 1 BP E125 EP E129 DI 10.1016/j.jss.2010.07.060 PG 5 WC Surgery SC Surgery GA 700MR UT WOS:000285747600018 PM 20863522 ER PT J AU Bradley, M Sabatier, JM AF Bradley, Marshall Sabatier, James M. TI Applications of Fresnel-Kirchhoff diffraction theory in the analysis of human-motion Doppler sonar grams SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article AB Observed human-gait features in Doppler sonar grams are explained by using the Boulic-Thalmann (BT) model to predict joint angle time histories and the temporal displacements of the body center of mass. Body segments are represented as ellipsoids. Temporally dependent velocities at the proximal and distal end of key body segments are determined from BT. Doppler sonar grams are computed by mapping velocity-time dependent spectral acoustic-cross sections for the body segments onto time-velocity space, mimicking the Short Time Fourier Transform used in the Doppler sonar processing. Comparisons to measured data indicate that dominant returns come from trunk, thigh and lower leg. (C) 2010 Acoustical Society of America C1 [Bradley, Marshall] Univ Mississippi, Natl Ctr Phys Acoust, University, MS 38677 USA. [Sabatier, James M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Bradley, M (reprint author), Univ Mississippi, Natl Ctr Phys Acoust, 1 Coliseum Dr, University, MS 38677 USA. EM rrbradle@olemiss.edu; sabatier@olemiss.edu FU Department of the Army, Army Armament Research, Development, and Engineering Center [W15QKN-09-C-0163] FX This work was supported by Department of the Army, Army Armament Research, Development, and Engineering Center under Contract W15QKN-09-C-0163. NR 10 TC 4 Z9 4 U1 0 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD NOV PY 2010 VL 128 IS 5 BP EL248 EP EL253 DI 10.1121/1.3499702 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 685GT UT WOS:000284617900008 PM 21110534 ER PT J AU Mehmood, A Sabatier, JM Bradley, M Ekimov, A AF Mehmood, Asif Sabatier, James M. Bradley, Marshall Ekimov, Alexander TI Extraction of the velocity of walking human's body segments using ultrasonic Doppler SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID RADAR AB The focus of this paper is to experimentally extract the Doppler signatures of a walking human's individual body segments using an ultrasonic Doppler system (UDS) operating at 40 kHz. In a human's walk, the major contribution to Doppler velocities and acoustic scattering is from the foot, lower leg, thigh (upper leg) and torso. The Doppler signature of these human body segments are extracted experimentally. The measurements were made by illuminating one of these body segments at a time and blocking the remaining body segments using acoustic screens. The results obtained in our experiment were verified with the results published by Bradley using a physics-based model for Doppler sonar spectrograms. C1 [Mehmood, Asif; Sabatier, James M.] USA, Res Lab, Adelphi, MD 20783 USA. [Bradley, Marshall; Ekimov, Alexander] Univ Mississippi, Natl Ctr Phys Acoust, University, MS 38677 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1@us.army.mil; james.sabatier@us.army.mil NR 8 TC 7 Z9 7 U1 0 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD NOV PY 2010 VL 128 IS 5 BP EL316 EP EL322 DI 10.1121/1.3501115 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 685GT UT WOS:000284617900019 PM 21110545 ER PT J AU Alves, DA Bell, TM Benton, C Rushing, EJ Stevens, EL AF Alves, Derron A. Bell, Todd M. Benton, Carrie Rushing, Elisabeth J. Stevens, Edward L. TI Giant Thoracic Schwannoma in a Rhesus Macaque (Macaca mulatta) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID NERVE SHEATH TUMORS; MALIGNANT SCHWANNOMA; PLEXIFORM; GOAT AB A 15-y-old male rhesus macaque with a 3-d history of labored breathing, was culled from a nonhuman primate research colony after thoracic radiographs and exploratory surgery revealed a 10-cm, well-circumscribed space-occupying mass in the posterior thoracic cavity The multilobulated cystic and necrotic neoplasm was composed of interlacing streams and fascicles of neoplastic spindle cells arranged in Antoni A, and less commonly, Antoni B patterns Verocay bodies were present also The neoplasm was encapsulated mostly, and histomorphologic features were benign Immunohistochemistry indicated that neoplastic cells were positive for vimentin, S100, glial fibrillary acidic protein, and nerve growth factor receptor Reticulin histochemical staining and immunohistochemical stains for collagen IV and laminin showed a prominent basal lamina surrounding the neoplastic cells The histologic features and results of the immunohistochemical stains confirmed peripheral nerve origin and were consistent with schwannoma To our knowledge, this is the first case of thoracic schwannoma in a rhesus macaque and the second reported case of schwannoma in a nonhuman primate C1 [Alves, Derron A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Benton, Carrie] USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. [Bell, Todd M.; Stevens, Edward L.] Armed Forces Inst Pathol, Dept Vet Pathol, Washington, DC 20306 USA. [Rushing, Elisabeth J.] Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. RP Alves, DA (reprint author), USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. NR 31 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2010 VL 49 IS 6 BP 868 EP 872 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 687PZ UT WOS:000284791700015 PM 21205456 ER PT J AU Inaba, K Lustenberger, T Rhee, P Holcomb, JB Blackbourne, LH Shulman, I Nelson, J Talving, P Demetriades, D AF Inaba, Kenji Lustenberger, Thomas Rhee, Peter Holcomb, John B. Blackbourne, Lorne H. Shulman, Ira Nelson, Janice Talving, Peep Demetriades, Demetrios TI The Impact of Platelet Transfusion in Massively Transfused Trauma Patients SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID FRESH-FROZEN PLASMA; LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; RED-BLOOD-CELLS; LAST 60 YEARS; AGGRESSIVE USE; EXSANGUINATION PROTOCOL; PRODUCT UTILIZATION; CONTROL HEMATOLOGY; IMPROVED SURVIVAL AB BACKGROUND: The impact of platelet transfusion in trauma patients undergoing a massive transfusion (MT) was evaluated. STUDY DESIGN: The Institutional Trauma Registry and Blood Bank Database at a Level I trauma center was used to identify all patients requiring an MT (>= 10 packed red blood cells [PRBC] within 24 hours of admission). Mortality was evaluated according to 4 apheresis platelet (aPLT):PRBC ratios: Low ratio (<1:18), medium ratio (1:18 and <1:12), high ratio (1:12 and <1:6), and highest ratio (>= 1:6). RESULTS: Of 32,289 trauma patients, a total of 657 (2.0%) required an MT. At 24 hours, 171 patients (26.0%) received a low ratio, 77 (11.7%) a medium ratio, 249 (37.9%) a high ratio, and 160 (24.4%) the highest ratio of aPLT:PRBC. After correcting for differences between groups, the mortality at 24 hours increased in a stepwise fashion with decreasing aPLT:PRBC ratio. Using the highest ratio group as a reference, the adjusted relative risk of death was 1.67 (adjusted p = 0.054) for the high ratio group, 2.28 (adjusted p = 0.013) for the medium ratio group, and 5.51 (adjusted p < 0.001) for the low ratio group. A similar stepwise increase in mortality with decreasing platelet ratio was observed at 12 hours after admission and for overall survival to discharge. After stepwise logistic regression, a high aPLT:PRBC ratio (adjusted p < 0.001) was independently associated with improved survival at 24 hours. CONCLUSIONS: For injured patients requiring a massive transfusion, as the apheresis platelet-to-red cell ratio increased, a stepwise improvement in survival was seen. Prospective evaluation of the role of platelet transfusion in massively transfused patients is warranted. (J Am Coll Surg 2010;211: 573-579. (C) 2010 by the American College of Surgeons) C1 [Rhee, Peter] Univ Arizona, Div Trauma Crit Care & Emergency Surg, Tucson, AZ USA. [Holcomb, John B.] Univ Texas Med Sch Houston, Ctr Translat Injury Res, Div Acute Care Surg, Houston, TX USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Shulman, Ira; Nelson, Janice] Univ So Calif, Med Ctr, Dept Pathol, Los Angeles, CA 90033 USA. [Inaba, Kenji; Lustenberger, Thomas; Talving, Peep; Demetriades, Demetrios] Los Angeles Cty & Univ So Calif Med Ctr, Div Trauma Emergency Surg & Surg Crit Care, Los Angeles, CA USA. RP Inaba, K (reprint author), Univ So Calif, Keck Sch Med, Div Trauma Emergency Surg & Surg Crit Care, LAC USC Med Ctr, 1200 N State St,IPT,C5L100, Los Angeles, CA 90033 USA. EM kinaba@surgery.usc.edu RI Talving, Peep/G-8621-2015 OI Talving, Peep/0000-0002-9741-2073 NR 45 TC 51 Z9 52 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD NOV PY 2010 VL 211 IS 5 BP 573 EP 579 DI 10.1016/j.jamcollsurg.2010.06.392 PG 7 WC Surgery SC Surgery GA 681FS UT WOS:000284297400001 PM 20846882 ER PT J AU Tyler, JA Clive, KS White, CE Beekley, AC Blackbourne, LH AF Tyler, Joshua A. Clive, Kevin S. White, Christopher E. Beekley, Alec C. Blackbourne, Lorne H. TI Current US Military Operations and Implications for Military Surgical Training SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID MANAGEMENT COURSE; ENDURING-FREEDOM; IRAQI-FREEDOM; AFGHANISTAN; DEATH; WAR AB BACKGROUND: Since 2001, US military surgeons have deployed frequently, with many surgeons deploying within 1 year of graduating residency. The purpose of this study was to evaluate readiness of recent graduates to manage combat-related injuries and to make recommendations for improvements in training military surgeons. STUDY DESIGN: We reviewed casualties treated at the 31(st) Combat Support Hospital in Baghdad from December 2003 to November 2004. We identified 3,426 wounded patients; of these, 2,648 (77.3%) required an operative procedure. There were 2,788 patients (81.4%) who sustained penetrating injuries. The most common procedures performed were debridement of wounds (39%), skeletal fixation (14.7%), and exploratory laparotomy (11.4%). Common procedures were compared with 15 case logs from the ACGME database for our institution from 2005 to 2009. RESULTS: Graduating residents averaged 973 cases during residency (range 867 to 1,293, median 921). This included experience with most procedures encountered except nephrectomy (1.5 procedures per resident [PPR]), craniotomy (1.1 PPRs), inferior vena cava injury (1.1 PPRs), bladder repair (0.87 PPR), and duodenal injury (0.6 PPR). Residents had minimal experience with skeletal fixation and external genital trauma. CONCLUSIONS: Recent surgical residency graduates are prepared for deployment in support of US military operations for the majority of injuries encountered. However, familiarization with procedures that fall outside the traditional general surgical curriculum would improve their ability to treat these injuries. To enhance experience with rare injuries, cadaver studies and animal models may serve as training tools before deployment. (J Am Coll Surg 2010;211:658-662. (C) 2010 by the American College of Surgeons) C1 [Tyler, Joshua A.] Brooke Army Med Ctr, Dept Gen Surg, USAF, MC, Ft Sam Houston, TX 78234 USA. [White, Christopher E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Beekley, Alec C.] Madigan Army Med Ctr, Dept Gen Surg, Tacoma, WA 98431 USA. RP Tyler, JA (reprint author), Brooke Army Med Ctr, Dept Gen Surg, USAF, MC, 3851 Roger Brooke Dr MCHE SDG, Ft Sam Houston, TX 78234 USA. EM Josh.Tyler@amedd.army.mil NR 18 TC 13 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD NOV PY 2010 VL 211 IS 5 BP 658 EP 662 DI 10.1016/j.jamcollsurg.2010.07.009 PG 5 WC Surgery SC Surgery GA 681FS UT WOS:000284297400012 PM 20869271 ER PT J AU Al-Aly, Z Zeringue, A Fu, J Rauchman, MI McDonald, JR El-Achkar, TM Balasubramanian, S Nurutdinova, D Xian, H Stroupe, K Abbott, KC Eisen, S AF Al-Aly, Ziyad Zeringue, Angelique Fu, John Rauchman, Michael I. McDonald, Jay R. El-Achkar, Tarek M. Balasubramanian, Sumitra Nurutdinova, Diaria Xian, Hong Stroupe, Kevin Abbott, Kevin C. Eisen, Seth TI Rate of Kidney Function Decline Associates with Mortality SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID GLOMERULAR-FILTRATION-RATE; NONTRADITIONAL RISK-FACTORS; CORONARY-HEART-DISEASE; REVERSE EPIDEMIOLOGY; RENAL-DISEASE; UNITED-STATES; CARDIOVASCULAR OUTCOMES; VASCULAR CALCIFICATION; DIABETES-MELLITUS; SERUM CREATININE AB The effect of rate of decline of kidney function on risk for death is not well understood Using the Department of Veterans Affairs national databases, we retrospectively studied a cohort of 4171 patients who had rheumatoid arthritis and early stage 3 chronic kidney disease (CKD, estimated GFR 45 to 60 ml/min) and followed them longitudinally to characterize predictors of disease progression and the effect of rate of kidney function decline on mortality After a median of 2 6 years, 1604 (38%) maintained stable kidney function, 426 (10%), 1147 (28%), and 994 (24%) experienced mild moderate, and severe progression of CKD, respectively (defined as estimated GFR decline of 0 to 1, 1 to 4, and >4 ml/min per yr) Peripheral artery disease predicted moderate progression of CKD progression Black race, hypertension, diabetes, cardiovascular disease, and peripheral artery disease predicted severe progression of CKD After a median of 5 7 years, patients with severe progression had a significantly increased risk for mortality (hazard ratio 1 54 95% confidence interval 1 30 to 1 82) compared with those with mild progression, patients with moderate progression exhibited a similar trend (hazard ratio 1 10 95% confidence interval 0 98 to 1 30) Our results demonstrate an independent and graded association between the rate of kidney function decline and mortality Incorporating the rate of decline into the definition of CKD may transform a static definition into a dynamic one that more accurately describes the potential consequences of the disease for an individual C1 [Al-Aly, Ziyad; Rauchman, Michael I.; El-Achkar, Tarek M.] St Louis Vet Affairs Med Ctr, Div Nephrol, St Louis, MO 63106 USA. [Al-Aly, Ziyad; Zeringue, Angelique; Fu, John; McDonald, Jay R.; Balasubramanian, Sumitra; Nurutdinova, Diaria; Xian, Hong; Eisen, Seth] St Louis Vet Affairs Clin Res & Epidemiol Ctr, St Louis, MO USA. [Fu, John] St Louis Univ, Div Biostat, Sch Publ Hlth, St Louis, MO 63103 USA. [McDonald, Jay R.; Nurutdinova, Diaria] Washington Univ, Sch Med, Div Infect Dis, St Louis, MO 63110 USA. [Stroupe, Kevin] Edward Hines Vet Affairs Med Ctr, Ctr Management Complex Chron Care, Hines, IL USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Div Nephrol, Washington, DC 20307 USA. [Eisen, Seth] US Dept Vet Affairs, Washington, DC USA. RP Al-Aly, Z (reprint author), St Louis Vet Affairs Med Ctr, Div Nephrol, 915 N Grand Blvd,111B JC, St Louis, MO 63106 USA. RI Zeringue, Angelique/I-1755-2012; Al-Aly, Ziyad/S-4439-2016; OI Al-Aly, Ziyad/0000-0002-2600-0434; Abbott, Kevin/0000-0003-2111-7112 FU Department of Veterans Affairs [VISN 15] FX This work was funded by a Department of Veterans Affairs VISN 15 Career Development Award to Ziyad Al-Aly, M D NR 48 TC 85 Z9 86 U1 1 U2 5 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD NOV PY 2010 VL 21 IS 11 BP 1961 EP 1969 DI 10.1681/ASN.2009121210 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 689ZL UT WOS:000284969500020 PM 20947634 ER PT J AU Thorne, DR AF Thorne, David R. TI IDENTITIES AND THEIR USES RESPONSE TO "RATE, PROBABILITY AND MATCHING" BY RACHLIN AND LOCEY SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Editorial Material DE identity; tautology; law matching; reinforcement; probability reinforcement rate; running rate; postreinforcement; pause; bout ID VARIABLE-INTERVAL SCHEDULES; FEEDBACK FUNCTIONS; REINFORCEMENT; LAW AB Some of the differences between Rachlin & Locey (2010) and Thorne (2010) are due to what assumptions are taken as givens versus questionable Most of the other apparent differences art largely linguistic and can be resolved by agreeing on terminology The identity combining both late and probability of reinforcement is general has already revealed order not previously noted even in its currently simple form and provides a way of incorporating additional variables known to influence and characterize behavior C1 Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat Neurosci, Silver Spring, MD 20910 USA. RP Thorne, DR (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat Neurosci, Silver Spring, MD 20910 USA. NR 16 TC 0 Z9 0 U1 1 U2 1 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 USA SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD NOV PY 2010 VL 94 IS 3 BP 369 EP 372 DI 10.1901/jeab.2010.94-369 PG 4 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA 681HE UT WOS:000284301200008 ER PT J AU Gavini, V Knap, J Bhattacharya, K Ortiz, M AF Gavini, Vikram Knap, Jaroslaw Bhattacharya, Kaushik Ortiz, Michael TI Non-periodic finite-element formulation of orbital-free density functional theory (vol 55, pg 669, 2007) SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Correction C1 [Gavini, Vikram] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Knap, Jaroslaw] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Bhattacharya, Kaushik; Ortiz, Michael] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA. RP Gavini, V (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM vikramg@umich.edu NR 1 TC 0 Z9 0 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD NOV PY 2010 VL 58 IS 11 BP 1834 EP 1834 DI 10.1016/j.jmps.2010.08.003 PG 1 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 676HK UT WOS:000283901400005 ER PT J AU Parsons, EM Weerasooriya, T Sarva, S Socrate, S AF Parsons, Ethan M. Weerasooriya, Tusit Sarva, Sai Socrate, Simona TI Impact of woven fabric: Experiments and mesostructure-based continuum-level simulations SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE Dynamics; Constitutive behavior; Finite elements; Impact testing; Woven fabric ID NONORTHOGONAL CONSTITUTIVE MODEL; SHELL FINITE-ELEMENT; BALLISTIC IMPACT; MECHANICAL-BEHAVIOR; TEXTILE STRUCTURES; TRANSVERSE IMPACT; ENERGY-ABSORPTION; TENSILE BEHAVIOR; ARMOR; PERFORMANCE AB Woven fabric is an increasingly important component of many defense and commercial systems, including deployable structures, restraint systems, numerous forms of protective armor, and a variety of structural applications where it serves as the reinforcement phase of composite materials. With the prevalence of these systems and the desire to explore new applications, a comprehensive, computationally efficient model for the deformation of woven fabrics is needed. However, modeling woven fabrics is difficult due, in particular, to the need to simulate the response both at the scale of the entire fabric and at the meso-level, the scale of the yarns that compose the weave. Here, we present finite elements for the simulation of the three-dimensional, high-rate deformation of woven fabric. We employ a continuum-level modeling technique that, through the use of an appropriate unit cell, captures the evolution of the mesostructure of the fabric without explicitly modeling every yarn. Displacement degrees of freedom and degrees of freedom representing the change in crimp amplitude of each yarn family fully determine the deformed geometry of the mesostructure of the fabric, which in turn provides, through the constitutive relations, the internal nodal forces. In order to verify the accuracy of the elements, instrumented ballistic impact experiments with projectile velocities of 22-550 m/s were conducted on single layers of Kevlar (R) fabric. Simulations of the experiments demonstrate that the finite elements are capable of efficiently simulating large, complex structures. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Parsons, Ethan M.; Socrate, Simona] MIT, Cambridge, MA 02139 USA. [Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sarva, Sai] Gen Elect Global Res, Niskayuna, NY 12309 USA. RP Parsons, EM (reprint author), MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM emoparsons@gmail.com FU U.S. Army Research Office through the MIT Institute for Soldier Nanotechnologies [W911NF-07-D-0004] FX This research was supported by the U.S. Army Research Office through the MIT Institute for Soldier Nanotechnologies under contract number W911NF-07-D-0004. We thank Professor R. Radovitzky for providing the explicit finite element framework, Adlib, in which we originally implemented the fabric model. NR 47 TC 20 Z9 20 U1 0 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD NOV PY 2010 VL 58 IS 11 BP 1995 EP 2021 DI 10.1016/j.jmps.2010.05.006 PG 27 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 676HK UT WOS:000283901400014 ER PT J AU Vorontsov, MA Lachinova, SL Beresnev, LA Weyrauch, T AF Vorontsov, Mikhail A. Lachinova, Svetlana L. Beresnev, Leonid A. Weyrauch, Thomas TI Obscuration-free pupil-plane phase locking of a coherent array of fiber collimators SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID LASER-BEAM PROJECTION; ADAPTIVE OPTICS; HIGH-POWER; SYSTEMS; OPTIMIZATION AB Control methods and system architectures that can be used for locking in phase of multiple laser beams that are generated at the transmitter aperture plane of a coherent fiber-collimator array system (pupil-plane phase locking) are considered. In the proposed and analyzed phase-locking techniques, sensing of the piston phase differences is performed using interference of periphery (tail) sections of the laser beams prior to their clipping by the fiber-collimator transmitter apertures. This obscuration-free sensing technique eliminates the need for a beam splitter being directly located inside the optical train of the transmitted beams-one of the major drawbacks of large-aperture and/or high-power fiber-array systems. Numerical simulation results demonstrate efficiency of the proposed phase-locking methods. (C) 2010 Optical Society of America C1 [Vorontsov, Mikhail A.; Weyrauch, Thomas] Univ Dayton, Sch Engn, Dayton, OH 45469 USA. [Lachinova, Svetlana L.] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. [Beresnev, Leonid A.] USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Vorontsov, MA (reprint author), Univ Dayton, Sch Engn, 300 Coll Pk, Dayton, OH 45469 USA. EM Mikhail.Vorontsov@udayton.edu FU Cooperative Agreement (CA) [W911NF-06-2-0009]; U.S. Army Research Laboratory (ARL) and the University of Maryland, College Park [W911NF-09-2-0040]; University of Dayton FX This work was supported in part by Cooperative Agreement (CA) W911NF-06-2-0009 between the U.S. Army Research Laboratory (ARL) and the University of Maryland, College Park, and by CA W911NF-09-2-0040 between ARL and the University of Dayton. NR 38 TC 9 Z9 10 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD NOV PY 2010 VL 27 IS 11 BP A106 EP A121 PG 16 WC Optics SC Optics GA 674GC UT WOS:000283723400013 PM 21045873 ER PT J AU Slim, AM Slim, JN Haney, BR Shry, EA AF Slim, Ahmad M. Slim, Jennifer N. Haney, Brian R. Shry, Eric A. TI Coronary Thrombus Detected by Cardiac CT Angiography Before Cardiac Catheterization SO JOURNAL OF THORACIC IMAGING LA English DT Article DE coronary CT; coronary thrombus; cardiac catheterization; cardiac MRI ID ACUTE CHEST-PAIN; MULTIDETECTOR COMPUTED-TOMOGRAPHY; ARTERY-DISEASE; STATEMENT; RISK AB A patient presented with a complaint of pleuritic chest discomfort with elevated cardiac biomarkers. After a cardiac magnetic resonance imaging scan for the suspicion of myopericarditis showed a potential myocardial infarct, a coronary CT scan was performed. This revealed a thrombus of the left anterior descending artery. Cardiac catheterization confirmed the findings, and a small clot was removed. To our knowledge, this is the first reported case of coronary thrombus being detected by CT angiography with cardiac catheterization correlation. Coronary CT angiography has been increasingly used to evaluate acute chest pain with a negative predictive value close to 100%. In a young patient with suspicion of myopericarditis, CT angiography proved to be useful in diagnosing thrombus in the coronary tree. C1 [Slim, Ahmad M.; Slim, Jennifer N.; Haney, Brian R.] Brooke Army Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. [Shry, Eric A.] Landstuhl Reg Med Ctr, Dept Cardiol, Landstuhl, Germany. RP Slim, AM (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Ahmad.slim@us.army.mil NR 10 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0883-5993 J9 J THORAC IMAG JI J. Thorac. Imaging PD NOV PY 2010 VL 25 IS 4 BP W118 EP W120 DI 10.1097/RTI.0b013e3181ced163 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 674DZ UT WOS:000283715600005 PM 20463613 ER PT J AU Spoerke, NJ Van, PY Differding, JA Zink, KA Cho, SD Muller, PJ Karahan, ZA Sondeen, JL Holcomb, JB Schreiber, MA AF Spoerke, Nicholas J. Van, Philbert Y. Differding, Jerome A. Zink, Karen A. Cho, S. David Muller, Patrick J. Karahan, Z. Ayhan Sondeen, Jill L. Holcomb, John B. Schreiber, Martin A. TI Red Blood Cells Accelerate the Onset of Clot Formation in Polytrauma and Hemorrhagic Shock SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 23rd Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 19-23, 2010 CL Phoenix, AZ SP Eastern Assoc Surg Trauma DE Coagulopathy; Polytrauma; Lyophilized plasma; Accelerated clot formation ID MASSIVE TRANSFUSION; COAGULOPATHY; TRAUMA; PLASMA; INJURY; RESUSCITATION; MORTALITY; MODEL AB Background: Hemorrhage and coagulopathy are major contributors to death after trauma. The contribution of red blood cells (RBCs) in correcting coagulopathy is poorly understood. Current methods of measuring coagulopathy may fail to accurately characterize in vivo clotting. We aimed to determine the effect of RBCs on clotting parameters by comparing resuscitation regimens containing RBCs and plasma with those containing plasma alone. Methods: Thirty-two Yorkshire swine were anesthetized, subjected to a complex model of polytrauma and hemorrhagic shock, and resuscitated with either fresh frozen plasma, lyophilized plasma (LP), or 1:1 ratios of fresh frozen plasma: packed RBC (PRBC) or LP:PRBC. Activated clotting time, prothrombin time, partial thromboplastin time, and thrombelastography (TEG) were performed at 1 hour, 2 hours, 3 hours, and 4 hours after resuscitation. Results: Animals treated with 1:1 LP:PRBC had less blood loss than the other groups (p < 0.05). The activated clotting time was shorter in the 1:1 groups when compared with the pure plasma groups at all time points (p < 0.05). The 1:1 groups had shorter TEG R times (time to onset of clotting) at 1 hour, 3 hours, and 4 hours compared with pure plasma groups (p < 0.05). Other TEG parameters did not differ between groups. Partial thromboplastin time was shorter in the pure plasma groups than the 1:1 groups at all time points (p < 0.05). Conclusions: Whole blood assays reveal that RBCs accelerate the onset of clot formation. Coagulation assays using spun plasma underestimate the effect of RBCs on clotting and do not completely characterize clot formation. C1 [Spoerke, Nicholas J.; Van, Philbert Y.; Differding, Jerome A.; Zink, Karen A.; Cho, S. David; Muller, Patrick J.; Karahan, Z. Ayhan; Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Dept Surg, Portland, OR 97239 USA. [Sondeen, Jill L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Div Acute Care Surg, Dept Surg, Houston, TX USA. RP Schreiber, MA (reprint author), Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Dept Surg, 3181 SW Sam Jackson Pk Rd,Mail Code L-611, Portland, OR 97239 USA. EM schreibm@ohsu.edu NR 15 TC 12 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2010 VL 69 IS 5 BP 1054 EP 1059 DI 10.1097/TA.0b013e3181f9912a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 678VK UT WOS:000284110100017 PM 21068611 ER PT J AU Kheirabadi, BS Mace, JE Terrazas, IB Fedyk, CG Valdez, KK MacPhee, MJ Beall, D Estep, JS Dubick, MA Blackbourne, LH AF Kheirabadi, Bijan Shams Mace, James E. Terrazas, Irasema B. Fedyk, Chriselda G. Valdez, Krystal K. MacPhee, Martin J. Beall, Dawson Estep, J. Scot Dubick, Michael A. Blackbourne, Lorne H. TI Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 23rd Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 19-23, 2010 CL Phoenix, AZ SP Eastern Assoc Surg Trauma DE Combat Gauze; WoundStat; Fibrinogen/fibrin dressing; Coagulopathy; Swine; FAST dressing ID EXTREMITY ARTERIAL HEMORRHAGE; 10 HEMOSTATIC DRESSINGS; REDUCE BLOOD-LOSS; V LIVER-INJURIES; RESUSCITATION VOLUME; COMBAT CASUALTIES; IMPROVE SURVIVAL; SWINE; MODEL; TRAUMA AB Background: Previous studies identified WoundStat (WS, smectite) and Combat Gauze (CG, kaolin-coated gauze) as the most effective available agents for controlling arterial bleeding with potential utility in casualty care. Tissue sealant properties of WS suggested its potential advantage over clot-promoting CG for treating coagulopathic bleeding. This study compared the efficacy of CG and WS with a fibrinogen-based (FAST) dressing to control bleeding in coagulopathic animals. Methods: Coagulopathy was induced in pigs (n = 55, 35 kg) by similar to 50% isovolemic hemodilution and hypothermia (core temperature, 33 degrees C +/- 0.5 degrees C). A 6-mm arteriotomy was made in the femoral artery and free bleeding allowed for 30 seconds. A test agent (n = 13-15 per group) or control product (gauze, GZ, n = 12) was applied to the wounds and compressed with a Kerlix gauze for 2 minutes. Fluid resuscitation was given, titrated to a mean arterial pressure of 65 mm Hg. Animals were observed for 180 minutes or until death. Angiography using the computed tomography method was performed on survivors, and local tissues were collected for histology. Results: No differences were seen in baseline measures. Coagulopathy, confirmed by a 31% increase in prothrombin time and a 28% reduction in clotting strength (maximum amplitude, thrombelastography assay), was similar in all groups before injury. The average pretreatment blood loss was 11.9 mL/kg +/- 0.4 mL/kg with no difference among groups. Posttreatment blood loss, however, was significantly different (p = 0.015) ranging from 18.2 mL/kg +/- 8.8 mL/kg (FAST) to 63.3 mL/kg +/- 10.2 mL/kg (GZ controls). Stable hemostasis was achieved in 10 of 13 (FAST), 5 of 15 (CG), 2 of 15 (WS), and 1 of 12 (GZ) animals in each group, resulting in significantly different survival rates (8-77%; p = 0.001). The average survival times were 145 (FAST), 119 (CG), 75 (WS), and 74 (GZ) minutes for different groups (p < 0.002). The outcomes with the FAST dressing were significantly better than with WS or GZ in this coagulopathic bleeding model. Essentially, no difference was found between WS and GZ control. Computed tomography images showed limited blood flow only through the vessels treated with FAST dressings. Histologic observations of the vessels indicated minimal damage with FAST and CG and greater injury with WS with some residues present on the tissues. Conclusion: The tissue sealant property of WS is apparently mediated by clot formation in the wound; therefore, it was ineffective under coagulopathic conditions. CG was partially effective in maintaining blood pressure up to 1 hour after application. FAST dressing showed the highest efficacy because of the exogenous delivery of concentrated fibrinogen and thrombin to the wound, which bypasses coagulopathy and secures hemostasis. C1 [Kheirabadi, Bijan Shams; Mace, James E.; Terrazas, Irasema B.; Fedyk, Chriselda G.; Valdez, Krystal K.; Estep, J. Scot; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Hemostasis Div, Ft Sam Houston, TX 78234 USA. [MacPhee, Martin J.; Beall, Dawson] STB Lifesaving Technol, Rockville, MD USA. RP Kheirabadi, BS (reprint author), 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@us.army.mil NR 31 TC 20 Z9 20 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2010 VL 69 IS 5 BP 1062 EP 1072 DI 10.1097/TA.0b013e3181fa0f21 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 678VK UT WOS:000284110100019 PM 21068612 ER PT J AU Gerlach, T Grayson, JK Pichakron, KO Sena, MJ DeMartini, SD Clark, BZ Estep, JS Zierold, D AF Gerlach, Travis Grayson, J. Kevin Pichakron, Kullada O. Sena, Matthew J. DeMartini, Steven D. Clark, Beth Z. Estep, J. Scot Zierold, Dustin TI Preliminary Study of the Effects of Smectite Granules (WoundStat) on Vascular Repair and Wound Healing in a Swine Survival Model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 51st Annual Meeting of the Society-of-Air-Force-Clinical-Surgeons CY APR 12, 2009 CL Denver, CO SP Soc Air Force Clin Surg DE Swine; Trauma; Hemostatics; Groin; Injuries; Wounds; Penetrating ID EXTREMITY ARTERIAL HEMORRHAGE; HEMOSTATIC PRODUCTS; TRAUMA; AGENTS AB Background: WoundStat (WS) (TraumaCure, Bethesda, MD) is a topical hemostatic agent that effectively stops severe hemorrhage in animal models. To the best of our knowledge, no survival study has been conducted to ensure long-term product safety. We evaluated vascular patency and tissue responses to WS in a swine femoral artery injury model with survival up to 5 weeks. Methods: Anesthetized swine received a standardized femoral artery injury with free hemorrhage for 45 seconds followed by WS application. One hour after application, the WS was removed, the wound copiously irrigated, and the artery repaired using a vein patch. Six groups of three animals received WS and were killed either immediately after surgery or at weekly intervals up to 5 weeks. Three control animals were treated with gauze packing and direct pressure followed by identical vascular repair and survival for 1 week. At the time of killing, angiograms were performed, and tissue was collected for histopathology. Results: Hemostasis was complete in all WS animals. All animals survived the procedure, and there were no clinically evident postoperative complications. Vascular repairs were angiographically patent in 15 of 18 animals (83%) receiving WS. Histopathologic examination of WS animals revealed severe diffuse fibrogranulomatous inflammation, early endothelial degeneration with subsequent intimal hyperplasia, moderate myocyte necrosis, and fibrogranulomatous nerve entrapment with axonal degeneration. Conclusion: Although an effective hemostatic agent, WS use was associated with a substantial local inflammatory response and neurovascular changes up to 5 weeks postinjury. C1 [Gerlach, Travis; Sena, Matthew J.] UC Davis Med Ctr, Dept Surg, Div Trauma & Emergency Surg, Sacramento, CA 95817 USA. [Estep, J. Scot] USA, Inst Surg Res, Dept Vet Pathol, Ft Sam Houston, TX 78234 USA. [Grayson, J. Kevin] David Grant USAF Med Ctr, Clin Investigat Facil, Travis AFB, CA USA. [Pichakron, Kullada O.; Zierold, Dustin] David Grant USAF Med Ctr, Dept Surg, Travis AFB, CA USA. [DeMartini, Steven D.; Clark, Beth Z.] David Grant USAF Med Ctr, Dept Pathol, Travis AFB, CA USA. RP Gerlach, T (reprint author), UC Davis Med Ctr, Dept Surg, Div Trauma & Emergency Surg, 2315 Stockton Blvd, Sacramento, CA 95817 USA. EM travis.gerlach@ucdmc.ucdavis.edu NR 18 TC 16 Z9 17 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2010 VL 69 IS 5 BP 1203 EP 1209 DI 10.1097/TA.0b013e3181c452b5 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 678VK UT WOS:000284110100047 PM 20068476 ER PT J AU Hsu, JR Stinner, DJ Rosenzweig, SD Salinas, J Dickson, KF AF Hsu, Joseph R. Stinner, Daniel J. Rosenzweig, Seth D. Salinas, Jose Dickson, Kyle F. TI Is There a Benefit to Drains With a Kocher-Langenbeck Approach? A Prospective Randomized Pilot Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Surgical drains; Suction drainage; Kocher-Langenbeck ID TOTAL JOINT ARTHROPLASTY; CLOSED SUCTION DRAINAGE; TOTAL KNEE ARTHROPLASTY; TOTAL HIP; ACETABULAR FRACTURES; ORTHOPEDIC-SURGERY; WOUND DRAINAGE; OPERATIONS; NONDRAINAGE; CULTURE AB Background: Closed suction drainage is a routine part of wound management for patients undergoing surgical treatment of acetabulum fractures. This pilot study seeks to determine if there is a difference in wound healing for a Kocher-Langenbeck approach with and without the use of drains. Methods: We conducted a prospective, randomized study including 39 patients with acetabulum fractures treated through a Kocher-Langenbeck approach. During wound closure, patients were randomized into two groups: 20 patients (group I) received drains and 19 (group II) were closed without drains. All were followed up for drain output, quality and quantity of drainage, signs of infection, and duration of drainage. Patients were then evaluated at 2 weeks and 8 weeks for wound healing and any signs of infection. Results: By the 8-week follow-up, all wounds healed without any signs of infection. There was no difference in the average number of days of drainage between groups: 7.45 days and 7.95 days for group I and group II, respectively (p = 0.37). There were two wound complications (5.13%), with one in each group. Both complications consisted of cellulitis without signs of deep infection and had complete resolution with intravenous antibiotics. A post hoc power analysis determined that a test population of 1,264 patients would be needed to show a reduction in wound drainage time by 1 day. Conclusion: With the numbers available in this pilot study, we showed no benefit to the use of drains for acetabular surgery performed through a Kocher-Langenbeck approach. C1 [Stinner, Daniel J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. Univ Texas Houston, Chief Orthopaed Trauma Mem Hermann Hosp, Houston, TX 77030 USA. RP Stinner, DJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM daniel.stinner@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 27 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2010 VL 69 IS 5 BP 1222 EP 1225 DI 10.1097/TA.0b013e3181bc78cb PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 678VK UT WOS:000284110100051 PM 20375919 ER PT J AU Hudak, SJ Landt, CL Hernandez, J Soderdahl, DW AF Hudak, Steven J. Landt, Cristy L. Hernandez, Javier Soderdahl, Douglas W. TI External Validation of a Virtual Reality Transurethral Resection of the Prostate Simulator SO JOURNAL OF UROLOGY LA English DT Article DE prostate; prostatic hyperplasia; transurethral resection of prostate; computer simulation; education; medical ID TRAINER; VALIDITY; SKILLS AB Purpose: Virtual reality surgical simulation is an emerging technology that may eventually fill the gaps in surgical education created by changes in our medical system. We assessed the construct validity of a commercially available, virtual reality transurethral prostate resection simulator. Materials and Methods: Participants performed 2, 5-minute transurethral prostate resection exercises on a standardized virtual reality prostate. Data from the first exercise were discarded. Simulator based metrics from the second exercise were tabulated, including tissue resected in gm, number of cuts, coagulation time, number of coagulation attempts, tissue per cut in gm and blood loss. Complications were recorded. Performance metrics were compared between groups based on urological training level and prior real-world experience with transurethral prostate resection. Results: A total of 35 participants with varied levels of transurethral prostate resection experience completed the exercise. Several performance metrics had statistically significant correlations with urology training level and prior experience with transurethral prostate resection. There was a positive correlation of all measures of experience with mass resected, mass resected per cut and blood loss. Number of cuts correlated significantly with transurethral prostate resection experience in the previous year. Complications were present in most groups with medical students more likely to encounter external urethral sphincter and rectal injuries. Conclusions: We report the construct validity of a commercially available, virtual reality transurethral prostate resection simulator. The more experienced participants resected more tissue in a more efficient manner but with increased blood loss. Further investigations are needed before the widespread application of transurethral prostate resection simulators for training, certification and accreditation. C1 [Hudak, Steven J.] Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA. [Landt, Cristy L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Hudak, SJ (reprint author), Brooke Army Med Ctr, Dept Surg, Urol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM steven.hudak@us.army.mil NR 11 TC 11 Z9 12 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 2010 VL 184 IS 5 BP 2018 EP 2022 DI 10.1016/j.juro.2010.06.141 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 660XG UT WOS:000282679200068 PM 20850819 ER PT J AU Gurevich-Uvena, J Parker, JM Fitzpatrick, TM Makashay, MJ Perello, MM Blair, EA Solomon, NP AF Gurevich-Uvena, Joyce Parker, Joseph M. Fitzpatrick, Thomas M. Makashay, Matthew J. Perello, Michelle M. Blair, Elizabeth A. Solomon, Nancy Pearl TI Medical Comorbidities for Paradoxical Vocal Fold Motion (Vocal Cord Dysfunction) in the Military Population SO JOURNAL OF VOICE LA English DT Article DE Paradoxical vocal fold motion; Vocal cord dysfunction; Military; Asthma; Gastroesophageal reflux disease; Allergy; Postnasal drip ID ASTHMATICS AB Objectives/Hypotheses. This study aimed to describe the demographic characteristics of patients diagnosed with paradoxical vocal fold motion (PVFM) at Walter Reed Army Medical Center (WRAMC), and to document common medical comorbidities. The military population was expected to differ from the general population because of a presumed association between high physical demands and PVFM. Study Design. Retrospective chart review of active-duty (AD) military personnel compared with a natural control group of non-AD patients. Methods. Reports of asthma, allergy, gastroesophageal reflux disease (GERD), and postnasal drip (consequent to chronic sinusitis) were recorded for patients referred to the Speech Pathology Clinic at WRAMC with a diagnosis of PVFM from 1996 to 2001. Results. The cohort consisted of 265 patients, 127 of whom were on AD status. The AD group was significantly younger and represented a narrower age range (17-53 years) than the non-AD patients (8-80 years), and had a more balanced sex ratio (1.2:1 vs 2.9:1). Eighty percent of all patients had at least one of the medical comorbidities surveyed, and 51% had two or more factors. GERD and allergies were reported most commonly by both groups; only asthma occurred significantly more in non-AD than AD patients. Conclusions. PVFM referrals of AD personnel of the US military are characterized by younger patients and a smaller female: male ratio as compared with non-AD patients. Based on the preponderance of men in the military, the number of females in the AD group remained disproportionately large. Multiple medical comorbidities were commonly documented by both groups; the only significant difference was a greater prevalence of asthma in the non-AD group. These data reinforce the need for appropriate differential diagnosis in all patients. C1 [Gurevich-Uvena, Joyce; Makashay, Matthew J.; Solomon, Nancy Pearl] Walter Reed Army Med Ctr, Dept Surg, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Parker, Joseph M.; Fitzpatrick, Thomas M.; Perello, Michelle M.] Walter Reed Army Med Ctr, Dept Med Pulm & Crit Care Serv, Washington, DC 20307 USA. [Blair, Elizabeth A.] Walter Reed Army Med Ctr, Dept Surg Otolaryngol Head & Neck Serv, Washington, DC 20307 USA. RP Solomon, NP (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Nancy.P.Solomon@US.Army.mil NR 19 TC 6 Z9 6 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0892-1997 J9 J VOICE JI J. Voice PD NOV PY 2010 VL 24 IS 6 BP 728 EP 731 DI 10.1016/j.jvoice.2009.03.007 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 697EO UT WOS:000285495600015 PM 19892521 ER PT J AU Nwogu, O Demirbilek, Z AF Nwogu, Okey Demirbilek, Zeki TI Infragravity Wave Motions and Runup over Shallow Fringing Reefs SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Coral reefs; Ocean waves; Long-period surges; Runup; Infragravity waves ID CORAL-REEFS; SET-UP; SURF ZONE; FINITE-AMPLITUDE; WATER WAVES; BREAKING; PROPAGATION; MODEL; BEAT; FLOW AB This paper presents the results of a combined laboratory and numerical investigation into the role of infragravity motions in the wave runup process over fringing coral reefs. Laboratory experiments were performed with a reef profile typical of fringing reef systems along the southeast coast of Guam. Spectral analysis of the measured time histories of surface elevation over the reef face and flats show significant changes to the wave energy spectrum shoreward of the break point. Most of the wave energy in the incident wave frequency band is dissipated within a few wavelengths of the reef face with the wave motions over the reef flat and shoreline dominated by oscillations at infragravity periods [O(100s) prototype]. The infragravity wave energy is minimum at the reef crest and increases as waves propagate shoreward over the reef flat and also with increasing water level on the reef. The dominant infragravity mode is the first reef oscillation mode with a wavelength approximately equal to four times the width of the reef flat. This component is resonantly amplified at the shoreline relative to the incident infragravity energy at the reef crest. A numerical model based on the Boussinesq equations is applied to the laboratory data and is able to describe complex changes to the wave spectrum over the reef flat due to nonlinear wave-wave interactions and wave breaking as well as runup at the shoreline. C1 [Nwogu, Okey] Univ Michigan, Dept Naval Architecture & Marine Engn, Ann Arbor, MI 48109 USA. [Demirbilek, Zeki] USA, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Nwogu, O (reprint author), Univ Michigan, Dept Naval Architecture & Marine Engn, Ann Arbor, MI 48109 USA. FU Surge and Wave Island Modeling Studies (SWIMS); U.S. Army Engineer Research and Development Center; Chief of Engineers, U.S. Army Corps of Engineers FX This work was supported by the Surge and Wave Island Modeling Studies (SWIMS) and Navigation Systems programs of the U.S. Army Engineer Research and Development Center. Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corps of Engineers. NR 38 TC 33 Z9 34 U1 2 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 2010 VL 136 IS 6 BP 295 EP 305 DI 10.1061/(ASCE)WW.1943-5460.0000050 PG 11 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 670HL UT WOS:000283411700001 ER PT J AU Jepsen, R Roberts, J Gailani, J AF Jepsen, Richard Roberts, Jesse Gailani, Joseph TI Effects of Bed Load and Suspended Load on Separation of Sands and Fines in Mixed Sediment SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Bed load; Sediment; Sand; Silt; Separation; Transport; Suspension ID BULK-DENSITY; EROSION; TRANSPORT; THRESHOLD; FLUME; SEA AB An adjustable shear stress straight flume commonly used to measure cohesive sediment erosion rates has been modified to include downstream bed load traps. The new flume can be used not only to measure erosion rates, but also to analyze and quantify the modes of transport for this complex problem. The new device was used to study transport modes of quartz particles ranging in size from 19 to 1,250 mu m. As expected, the traps captured the coarse material (bed load) and the fine material bypassed the traps (suspended load). Transport properties of natural sediments from three locations were also studied. Fine sediments with little or no sand eroded as aggregates which maintained their integrity in the flume channel while moving as bed load into the traps. Natural sediments that included high percentage of sand also eroded as aggregates. However, these aggregates quickly disaggregated. Sand moved as bed load and fell into the traps while fine particles moved predominately in suspension. C1 [Jepsen, Richard] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Roberts, Jesse] Sandia Natl Labs, Carlsbad, NM 88220 USA. [Gailani, Joseph] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Jepsen, R (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM rajepse@sandia.gov; jdrober@sandia.gov; Joe.Z.Gailani@usace.army.mil FU U.S. Army Corps of Engineers Engineering Research and Development Center; U.S. Army Corps of Engineers; Sandia Corporation, a Lockheed Martin Company FX This research was supported by the Dredging Operations and Environmental Research Program of the U.S. Army Corps of Engineers Engineering Research and Development Center. Permission to publish was granted by the office, Chief of Engineers, U.S. Army Corps of Engineers. Sandia National Laboratories is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company for the United States Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. NR 25 TC 0 Z9 1 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 2010 VL 136 IS 6 BP 319 EP 326 DI 10.1061/(ASCE)WW.1943-5460.0000054 PG 8 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 670HL UT WOS:000283411700003 ER PT J AU Dixit, AM Singh, H Meitzler, T AF Dixit, Arati M. Singh, Harpreet Meitzler, Thomas TI Soft Computing Approach to Crack Detection and FPGA Implementation SO MATERIALS EVALUATION LA English DT Article DE fuzzy logic; nondestructive testing techniques; crack detection; neuro-fuzzy logic; Mamdani technique; FPGA AB For many years, there has been considerable interest in applications of nondestructive testing (NDT) techniques of real-time crack detection. Various authors have suggested different approaches to find a solution to solve the problem of real-time crack detection (Meitzter et al., 2008; Zheng et al., 2008; Berthelot et al.,2000; Tong and Wu, 2001). This paper suggests a soft computing approach using fuzzy logic as an effective technique to solve the problem of real-time crack detection. It is also desirable to develop an integrated-circuit microprocessor chip, which can be used for the detection of cracks. The objectives of this paper are to report on efforts to develop an automated procedure for crack detection and to devise a technique so that the proposed technique can be easily implemented on a microprocessor chip. The developed fuzzy inference system is supported by the rule base which defines the behavior of a crack detection system. A very large-scale integration (VLSI) circuit for crack detection is developed on the basis of the fuzzy logic model and using a hardware description language (HDL). Field-programmable gate array (FPGA) implementation and circuit testing were also performed. C1 [Dixit, Arati M.; Singh, Harpreet] Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. [Meitzler, Thomas] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Dixit, AM (reprint author), Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. EM as7623@wayne.edu RI Meitzler, Thomas/D-1065-2017 NR 18 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC NONDESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD NOV PY 2010 VL 68 IS 11 BP 1263 EP 1272 PG 10 WC Materials Science, Characterization & Testing SC Materials Science GA 681UU UT WOS:000284346900003 ER PT J AU Ruiz, F Linton, YM Ponsonby, DJ Conn, JE Herrera, M Quinones, ML Velez, ID Wilkerson, RC AF Ruiz, Freddy Linton, Yvonne-Marie Ponsonby, David J. Conn, Jan E. Herrera, Manuela Quinones, Martha L. Velez, Ivan D. Wilkerson, Richard C. TI Molecular comparison of topotypic specimens confirms Anopheles (Nyssorhynchus) dunhami Causey (Diptera: Culicidae) in the Colombian Amazon SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Anopheles dunhami; COI barcodes; ITS2; topotypic; Brazil; Colombia ID DNA BARCODES; NUNEZTOVARI DIPTERA; SEQUENCE-ANALYSIS; ITS2 RDNA; MOSQUITOS; VECTORS AB The presence of Anopheles (Nyssorhynchus) dunhami Causey in Colombia (Department of Amazonas) is confirmed for the first time through direct comparison of mtDNA cytochrome c oxidase I (COI) barcodes and nuclear rDNA second internal transcribed spacer (ITS2) sequences with topotypic specimens of An. dunhami from Tefe, Brazil. An. dunhami was identified through retrospective correlation of DNA sequences following misidentification as Anopheles nuneztovari s.l. using available morphological keys for Colombian mosquitoes. That An. dunhami occurs in Colombia and also possibly throughout the Amazon Basin, is of importance to vector control programs, as this non-vector species is morphologically similar to known malaria vectors including An. nuneztovari, Anopheles oswaldoi and Anopheles trinkae. Species identification of An. dunhami and differentiation from these closely related species are highly robust using either DNA ITS2 sequences or COI DNA barcode. DNA methods are advocated for future differentiation of these often sympatric taxa in South America. C1 [Ruiz, Freddy; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Ruiz, Freddy; Linton, Yvonne-Marie] Nat Hist Museum, Dept Entomol, Mosquitoes Programme, London SW7 5BD, England. [Ruiz, Freddy; Ponsonby, David J.] Canterbury Christ Church Univ, Dept Geog & Life Sci, Canterbury, Kent, England. [Conn, Jan E.] New York State Dept Hlth, Griffin Lab, Wadsworth Ctr, Albany, NY USA. [Herrera, Manuela; Quinones, Martha L.] Univ Nacl Colombia, Fac Med, Bogota, Colombia. [Velez, Ivan D.] Univ Antioquia, Programa Estudio & Control Enfermedades Trop, Fac Med, Medellin, Colombia. RP Ruiz, F (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Av, Silver Spring, MD 20910 USA. EM ruizj@si.edu OI Conn, Jan/0000-0002-5301-7020 FU UNICEF/UNDP/WorldBank/WHO/TDR [A50252]; Canterbury Christ Church University, UK; NIH, USA [2R01AI054139]; Smithsonian Institution; Walter Reed Army Institute of Research FX UNICEF/UNDP/WorldBank/WHO/TDR (A50252 to YML), Canterbury Christ Church University, UK (PhD studentship for FR to DJP and YML), NIH, USA (2R01AI054139 to JEC), Smithsonian Institution, Walter Reed Army Institute of Research NR 30 TC 25 Z9 25 U1 1 U2 6 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD NOV PY 2010 VL 105 IS 7 BP 899 EP 903 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 687LB UT WOS:000284778900010 PM 21120360 ER PT J AU Servinsky, MD Kiel, JT Dupuy, NF Sund, CJ AF Servinsky, Matthew D. Kiel, James T. Dupuy, Nicole F. Sund, Christian J. TI Transcriptional analysis of differential carbohydrate utilization by Clostridium acetobutylicum SO MICROBIOLOGY-SGM LA English DT Article ID GLUCOSE PHOSPHOTRANSFERASE SYSTEM; ACETONE-BUTANOL FERMENTATION; CARBON CATABOLITE REPRESSION; BEIJERINCKII NCIMB 8052; SUCROSE TRANSPORT; BACILLUS-SUBTILIS; ATCC-824; METABOLISM; BACTERIA; OPERON AB Transcriptional analysis was performed on Clostridium acetobutylicum with the goal of identifying sugar-specific mechanisms for the transcriptional regulation of transport and metabolism genes. DNA microarrays were used to determine transcript levels from total RNA isolated from cells grown on media containing eleven different carbohydrates, including two pentoses (xylose, arabinose), four hexoses (glucose, mannose, galactose, fructose), four disaccharides (sucrose, lactose, maltose, cellobiose) and one polysaccharide (starch). Sugar-specific induction of many transport and metabolism genes indicates that these processes are regulated at the transcriptional level and are subject to carbon catabolite repression. The results show that C. acetobutylicum utilizes symporters and ATP-binding cassette (ABC) transporters for the uptake of pentose sugars, while disaccharides and hexoses are primarily taken up by phosphotransferase system (PTS) transporters and a gluconate : H(+) (GntP) transporter. The transcription of some transporter genes was induced by specific sugars, while others were induced by a subset of the sugars tested. Sugar-specific transport roles are suggested, based on expression comparisons, for various transporters of the PTS, the ABC superfamily and members of the major facilitator superfamily (MFS), including the GntP symporter family and the glycoside-pentoside-hexuronide (GPH)-cation symporter family. Additionally, updates to the C. acetobutylicum genome annotation are proposed, including the identification of genes likely to encode proteins involved in the metabolism of arabinose and xylose via the pentose phosphate pathway. C1 [Servinsky, Matthew D.; Kiel, James T.; Dupuy, Nicole F.; Sund, Christian J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Sund, CJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christian.sund@us.army.mil RI sund, christian/G-3424-2013 NR 49 TC 73 Z9 75 U1 4 U2 31 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD NOV PY 2010 VL 156 SI SI BP 3478 EP 3491 DI 10.1099/mic.0.037085-0 PN 11 PG 14 WC Microbiology SC Microbiology GA 685XC UT WOS:000284660400028 PM 20656779 ER PT J AU Teyhen, DS Thomas, RM Roberts, CC Gray, BE Robbins, T McPoil, T Childs, JD Molloy, JM AF Teyhen, Deydre S. Thomas, Rachelle M. Roberts, Candi C. Gray, Brian E. Robbins, Travis McPoil, Thomas Childs, John D. Molloy, Joseph M. TI Awareness and Compliance With Recommended Running Shoe Guidelines Among U.S. Army Soldiers SO MILITARY MEDICINE LA English DT Article ID MEDIAL LONGITUDINAL ARCH; EXTREMITY OVERUSE INJURY; TIBIAL STRESS SYNDROME; LOWER-LEG PAIN; RISK-FACTORS; MUSCULOSKELETAL INJURIES; PHYSICAL-ACTIVITY; BODY-COMPOSITION; CONTROLLED-TRIAL; FEMALE RECRUITS AB The purpose of this study was to determine awareness and compliance with recommended running shoe selection, sizing, and replacement guidelines among U.S. Army soldiers. Soldiers (n = 524) attending training at Fort Sam Houston, Texas completed self-report questionnaires and a foot assessment, which included measurement of foot size and arch height index. Researchers examined each soldier's running shoes for type, wear pattern, and general condition. Thirty-five percent of the soldiers wore shoes that were inappropriately sized; 56.5% wore shoes that were inappropriate for their foot type. Thirty-five percent of the soldiers had excessively worn shoes and 63% did not know recommended shoe replacement guidelines. Further efforts may be necessary to ensure that soldiers are aware of and compliant with recommended running shoe selection, sizing, and replacement guidelines. Future research is needed to determine whether adherence to these guidelines has a favorable effect on reducing risk of overuse injury. C1 [Teyhen, Deydre S.; Thomas, Rachelle M.; Roberts, Candi C.; Gray, Brian E.; Robbins, Travis; Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, AMEDDC&S,ATTN MCCS HGE PT, Ft Sam Houston, TX 78234 USA. [McPoil, Thomas] No Arizona Univ, NAU, Dept Phys Therapy, Flagstaff, AZ 86011 USA. [Molloy, Joseph M.] Brooke Army Med Ctr, Dept Phys Therapy, Ft Sam Houston, TX 78234 USA. RP Teyhen, DS (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, AMEDDC&S,ATTN MCCS HGE PT, 3151 Scott Rd,Room 1303, Ft Sam Houston, TX 78234 USA. NR 76 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 847 EP 854 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500006 PM 21121493 ER PT J AU Kamerath, JH De Luigi, AJ AF Kamerath, Joseph H. De Luigi, Arthur J. TI Analgesic Benefit of Niacin for Shrapnel Wound Pain in War Veteran SO MILITARY MEDICINE LA English DT Article AB We report a case of an 86-year-old male with a history of dyslipidemia, which had been treated with a medication regimen that included niacin. Upon discontinuation of niacin by his physician, he noticed recurrence of aching pain on the dorsal surface of the foot where he had a scar from a World War II shrapnel injury. With reinitation of niacin, his pain again abated. C1 [Kamerath, Joseph H.; De Luigi, Arthur J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kamerath, JH (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 876 EP 877 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500011 PM 21121498 ER PT J AU Koplovitz, I Schulz, S AF Koplovitz, Irwin Schulz, Susan TI Perspectives on the Use of Scopolamine as an Adjunct Treatment to Enhance Survival Following Organophosphorus Nerve Agent Poisoning SO MILITARY MEDICINE LA English DT Article ID GUINEA-PIGS; INDUCED SEIZURES; DRUG SELECTION; SOMAN; EFFICACY; ATROPINE; PROTECTION; ACETYLCHOLINESTERASE; DIAZEPAM; OXIMES AB Scopolamine (SCP) is an anticholinergic drug used clinically for decades to treat motion sickness, as a surgical preanesthetic, and as a smooth muscle antispasmodic. It has also been used experimentally as a pretreatment and/or treatment adjunct to mitigate the toxic sequelae of organophosphorus (OP) nerve agent intoxication. SCP has been reported to increase survival, prevent or terminate seizures, and reduce morbidity from nerve agent intoxication in a number of animal models. The purpose of this study was to evaluate the effect of atropine dose, pyridostigmine bromide (PB) pretreatment, and oxime selection on the efficacy of SCP as an adjunctive treatment to enhance survival following lethal nerve agent exposure in guinea pigs. The results indicate that the use of an effective oxime and/or PB pretreatment was a critical factor in determining the efficacy of SCP. SCP can also reduce the dose of atropine required for survival against lethal nerve agent intoxication. C1 [Koplovitz, Irwin; Schulz, Susan] USA, Med Res Inst Chem Def, Attn MCMR CDR P, Aberdeen Proving Ground, MD 21010 USA. RP Koplovitz, I (reprint author), USA, Med Res Inst Chem Def, Attn MCMR CDR P, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX The authors thank Stephen Robinson, William Aguilar, and Kelly Ault for their excellent technical assistance. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. NR 33 TC 4 Z9 5 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 878 EP 882 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500012 PM 21121499 ER PT J AU Klein, DA Gildengorin, G Mosher, P Adelman, WP AF Klein, David A. Gildengorin, Ginny Mosher, Peter Adelman, William P. TI Births to Adolescents in the U.S. Military Healthcare System SO MILITARY MEDICINE LA English DT Article ID DEPENDENT ADOLESCENTS; SEXUAL-ACTIVITY; PREGNANCY; BEHAVIOR; OUTCOMES; CHILDREN; MOTHERS; YOUTH; RISK; AGE AB Purpose: To describe the rate and sociodemographic profile of live births to adolescents having U.S. Department of Defense healthcare coverage because of parental military service. Methods: All live births identified from the M2 database during 2003-2006 to 10- to 23-year olds in this population were stratified and compared. Results: Birth rates rose in the 18- to 19- and 20- to 23-year-old groups over the 4 years studied (p < 0.05). Daughters of active duty personnel had higher live birth rates than daughters of retirees (7.1 vs. 6.1 age 15-17; p < 0.05). Birth rates differed among dependents of junior enlistees, senior enlistees, and officers (7.1, 9.4, 3.8, respectively; p < 0.0001). Conclusions: Adolescent dependents in this system have an increasing, though low, live birth rate. Those with active duty sponsors have a significantly higher rate than their age-matched peers with retired sponsors. Further study is warranted to identify factors unique to this population that may influence birth patterns. C1 [Klein, David A.] David Grant Med Ctr, Dept Family Med, Travis Afb, CA 94535 USA. [Mosher, Peter] David Grant Med Ctr, TRICARE Operat, Travis Afb, CA 94535 USA. [Adelman, William P.] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD 20889 USA. [Adelman, William P.] Walter Reed Army Med Ctr, Bethesda, MD 20889 USA. RP Klein, DA (reprint author), David Grant Med Ctr, Dept Family Med, Travis Afb, CA 94535 USA. NR 23 TC 5 Z9 5 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 890 EP 894 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500014 PM 21121501 ER PT J AU Krakauer, T Buckley, M Fisher, D AF Krakauer, Teresa Buckley, Marilyn Fisher, Diana TI Murine Models of Staphylococcal Enterotoxin B-Induced Toxic Shock SO MILITARY MEDICINE LA English DT Article ID CLASS-II MOLECULES; LETHAL SHOCK; BACTERIAL SUPERANTIGENS; TRANSGENIC MICE; HUMAN-DISEASE; T-CELLS; ACTIVATION; PROTECTS AB Staphylococcal enterotoxin B (SEB) is a member of a large family of structurally related exotoxins produced by Staphylococcus aureus, which is the etiological agent responsible for toxic shock and staphylococcal food poisoning. SEB binds directly to the major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and T-cell receptors on T cells triggering T-cell proliferation and mediator release. SEB is a biothreat agent because of its ability to potently activate cells of the immune system. In vivo animal models are critical in the development of therapeutics against SEB-induced shock. Our results show that three different mouse strains with different susceptibility to SEB can be used to study SEB-induced shock without the use of potentiating agents. The hypothermic response, weight loss, and induction of serum monocyte chemoattractant protein 1 (MCP-1), interleukin 2 (IL-2), and IL-6 correlated with mortality in all three models. C1 [Krakauer, Teresa; Buckley, Marilyn] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Fisher, Diana] USA, Med Res Inst Infect Dis, Div Stat, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. FU Defense Threat Reduction Agency FX We thank the Defense Threat Reduction Agency for support. NR 31 TC 9 Z9 11 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 917 EP 922 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500019 PM 21121506 ER PT J AU Hull, JE AF Hull, James E. TI Multisystem Organ Failure Due to Gemella morbillorum Native Valve Endocarditis SO MILITARY MEDICINE LA English DT Article ID INFECTIVE ENDOCARDITIS; STREPTOCOCCUS-MORBILLORUM; VIRIDANS STREPTOCOCCI; ASSOCIATION; SHOCK AB Gemella morbillorum is a gram positive cocci, considered normal flora of the upper respiratory tract, gastrointestinal tract, and genitourinary tract in humans. As a pathogen, there are reported cases of infectious endocarditis, bacteremia, sepsis, and abscesses, primarily associated with dental instrumentation, prosthetic heart valves, colon cancer, and endovascular access. We report a case of an 87-year-old Caucasian male with a history of a ruptured chordae of the anterior mitral leaflet, severe mitral regurgitation (MR), and atrial fibrillation who developed multisystem organ failure due to Gemella morbillorum native valve endocarditis without any precipitating factor. He was diagnosed per Duke criteria, treated with intravenous fluids, packed red blood cell transfusion, and broad spectrum antibiotics, with improvement in his clinical course. Our patient survived despite his generalized poor health, where he was eventually discharged to a skilled nursing facility. C1 Brooke Army Med Ctr, MDW Pulm Dis Inst 59, Ft Sam Houston, TX 78234 USA. RP Hull, JE (reprint author), Brooke Army Med Ctr, MDW Pulm Dis Inst 59, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 28 TC 3 Z9 4 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 923 EP 925 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500020 PM 21121507 ER PT J AU Samms, S Wittich, A Graf, K AF Samms, Shari Wittich, Arthur Graf, Kenneth TI Extraordinary Military Medical Care of a Pediatric Patient With Penetrating Pelvic Trauma: A Case Report SO MILITARY MEDICINE LA English DT Article ID MANAGEMENT; INJURIES AB Modern military medicine is an ever advancing field, capable of remarkable feats. We present the case of a 16-year-old Iraqi female with a single gunshot wound to the pelvis with extensive rectal injury who survived despite the odds. Using "damage control" techniques, this patient survived despite a reported 30% mortality associated with such wounds. During the course of her stay, she was cared for by a multidisciplinary team whose integrated efforts led to survival and complete closure of 2 of 3 wounds prior to discharge. The case demonstrates the success of modern military medical measures applied to a malnourished pediatric civilian in an austere environment. In addition to being noteworthy as an extraordinary case of survival, this case raises questions about the implications of practicing short term modern medicine on a population that will have to be reintegrated into a primitive medical establishment, possibly before definitive care is complete. C1 [Samms, Shari] Clark Hlth Clin, Ft Bragg, NC 28310 USA. [Wittich, Arthur] DeWitt Army Community Hosp, Dept Obstet Gynecol, Ft Belvoir, VA 22060 USA. [Graf, Kenneth] Lebanon VA Med Ctr, Lebanon, PA 17042 USA. RP Samms, S (reprint author), Clark Hlth Clin, Bldg 5-4256,Bastogne Dr Extens, Ft Bragg, NC 28310 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2010 VL 175 IS 11 BP 926 EP 928 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 679TK UT WOS:000284183500021 PM 21121508 ER PT J AU Sheridan, SC Kalkstein, AJ AF Sheridan, Scott C. Kalkstein, Adam J. TI Seasonal variability in heat-related mortality across the United States SO NATURAL HAZARDS LA English DT Article DE Heat watch-warning system; Atmospheric hazards; Heat-related mortality; Seasonal cycle; Heat vulnerability ID TEMPERATURE-RELATED MORTALITY; PUBLIC-HEALTH; US CITIES; SUMMER TEMPERATURE; WINTER-MORTALITY; CLIMATE-CHANGE; ALL-CAUSE; IMPACTS; WAVE; LONDON AB This study examines the seasonal variability in the heat mortality relationship across 29 US metropolitan areas from 1975 to 2004 to discern the seasonal cycle of the health risk from anomalously high temperatures (relative to the time of season). Mortality data for the 30-year period are standardized to account for population trends and overall seasonal and interannual variability. On days when a city experienced an "oppressive" air mass, mean anomalous mortality was calculated. Results show that while the greatest overall health impact is found mid-summer in many locations due to the peak frequency of hot weather occurring at this time, the relative increase in acute mortality on oppressive air mass days is actually just as large in spring as it is in summer, and in some cases is larger. Late summer and autumn vulnerability to anomalously warm or hot days is much less significant than spring days in all areas except along the Pacific coast. Results show significant spatial variability, with the most consistent results across the more 'traditionally' heat vulnerable areas of the Midwestern and northeastern US, along with the Pacific Coast. Elsewhere, the seasonal cycle of the correlation between anomalously high temperatures and human health is more ambiguous. C1 [Sheridan, Scott C.] Kent State Univ, Dept Geog, Kent, OH 44242 USA. [Kalkstein, Adam J.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Sheridan, SC (reprint author), Kent State Univ, Dept Geog, 413 McGilvrey Hall, Kent, OH 44242 USA. EM ssherid1@kent.edu NR 40 TC 23 Z9 23 U1 2 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD NOV PY 2010 VL 55 IS 2 BP 291 EP 305 DI 10.1007/s11069-010-9526-5 PG 15 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 671MJ UT WOS:000283509900010 ER PT J AU Hartman, IZ Kim, A Cotter, RJ Walter, K Dalai, SK Boronina, T Griffith, W Lanar, DE Schwenk, R Krzych, U Cole, RN Sadegh-Nasseri, S AF Hartman, Isamu Z. Kim, AeRyon Cotter, Robert J. Walter, Kimberly Dalai, Sarat K. Boronina, Tatiana Griffith, Wendell Lanar, David E. Schwenk, Robert Krzych, Urszula Cole, Robert N. Sadegh-Nasseri, Scheherazade TI A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes SO NATURE MEDICINE LA English DT Article ID LIVER-STAGE ANTIGEN-1; COLLAGEN TYPE-II; HLA-DM; PLASMODIUM-FALCIPARUM; MASS-SPECTROMETRY; T-CELLS; REMNANT EPITOPES; MHC MOLECULES; GELATINASE-B; CATHEPSIN-S AB Immunodominance is defined as restricted responsiveness of T cells to a few selected epitopes from complex antigens. Strategies currently used for elucidating CD4(+) T cell epitopes are inadequate. To understand the mechanism of epitope selection for helper T cells, we established a cell-free antigen processing system composed of defined proteins: human leukocyte antigen-DR1 (HLA-DR1), HLA-DM and cathepsins. Our reductionist system successfully identified the physiologically selected immunodominant epitopes of two model antigens: hemagglutinin-1 (HA1) from influenza virus (A/Texas/1/77) and type II collagen (CII). When applied for identification of new epitopes from a recombinant liver-stage antigen of malaria falciparum (LSA-NRC) or HA1 from H5N1 influenza virus ('avian flu'), the system selected single epitopes from each protein that were confirmed to be immunodominant by their capacity to activate CD4(+) T cells from H5N1-immunized HLA-DR1-transgenic mice and LSA-NRC-vaccinated HLA-DR1-positive human volunteers. Thus, we provide a new tool for the identification of physiologically relevant helper T cell epitopes from antigens. C1 [Hartman, Isamu Z.; Kim, AeRyon; Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Grad Program Immunol, Baltimore, MD 21218 USA. [Cotter, Robert J.; Griffith, Wendell] Johns Hopkins Univ, Sch Med, Dept Pharmacol, Baltimore, MD 21205 USA. [Walter, Kimberly; Dalai, Sarat K.; Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Boronina, Tatiana; Cole, Robert N.] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA. [Lanar, David E.; Schwenk, Robert; Krzych, Urszula] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Cole, Robert N.] Johns Hopkins Univ, Sch Med, Mass Spectrometry & Prote Facil, Inst Basic Biomed Sci, Baltimore, MD USA. RP Sadegh-Nasseri, S (reprint author), Johns Hopkins Univ, Sch Med, Grad Program Immunol, Baltimore, MD 21218 USA. EM ssadegh@jhmi.edu RI Lanar, David/B-3560-2011; OI Sadegh-Nasseri, Scheherazade/0000-0002-8127-1720 FU Johns Hopkins Malaria Research Institute [AI063764, GM053549]; US National Science Foundation; Johns Hopkins University Rheumatology FX We wish to thank S. Landry, A. Hamad, J. Pomerantz and K. Narayan for reading the manuscript and insightful discussions, S. Khoruzhenko for protein production, S. Kalb-Ramirez and D. Wang for the initial mass spectrometry, F. Korangy and D. Pardoll (Johns Hopkins University) for Escherichia coli transformed with an expression vector encoding influenza HA, D. Zaller (Merck) for the original DR1-transgenic mice, L. Rein for testing the human samples and the US National Institutes of Health Tetramer Facility for providing DR1 and CLIP monomers. This work was supported by R01 grants AI063764 and GM053549, a grant from Johns Hopkins Malaria Research Institute to S.S.-N., a US National Science Foundation predoctoral award to I.Z.H. and a Johns Hopkins University Rheumatology T32 Fellowship to A.K. NR 37 TC 22 Z9 22 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD NOV PY 2010 VL 16 IS 11 BP 1333 EP U192 DI 10.1038/nm.2248 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 675TV UT WOS:000283860100047 PM 21037588 ER PT J AU Whitley, RJ Hromadka, TV Horton, SB AF Whitley, R. J. Hromadka, T. V., II Horton, S. B. TI Approximating Solutions to the Dirichlet Problem in R-N Using One Analytic Function SO NUMERICAL METHODS FOR PARTIAL DIFFERENTIAL EQUATIONS LA English DT Article DE complex variable methods; Dirichlet problem; harmonic polynomials AB A simpler proof is given of the result of (Whitley and Hromadka II, Numer Methods Partial Differential Eq 21 (2005) 905-917) that, under very mild conditions, any solution to a Dirichlet problem with given continuous boundary data can be approximated by a sum involving a single function of one complex variable; any analytic function not a polynomial can be used. This can be applied to give a method for the numerical solution of potential problems in dimension three or higher. (C) 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 26: 1636-1641, 2010 C1 [Hromadka, T. V., II; Horton, S. B.] US Mil Acad, Dept Math Sci, West Point, NY 10096 USA. RP Whitley, RJ (reprint author), POB 11133, Bainbridge Isl, WA 98110 USA. EM rwhitley@math.uci.edu NR 7 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0749-159X J9 NUMER METH PART D E JI Numer. Meth. Part Differ. Equ. PD NOV PY 2010 VL 26 IS 6 BP 1636 EP 1641 DI 10.1002/num.20515 PG 6 WC Mathematics, Applied SC Mathematics GA 661PE UT WOS:000282739400026 ER PT J AU Cho, RI Elner, VM AF Cho, Raymond I. Elner, Victor M. TI Closure of Mid-Posterior Tenon's Capsule in Enucleation SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID IMPLANTS; EVISCERATION; EXPOSURE AB Purpose: To evaluate the potential advantages of closing mid-posterior Tenon's capsule during enucleation surgery by comparing its thickness and relative tissue strength with anterior Tenon's capsule. To evaluate surgical outcomes of enucleation using mid-posterior Tenon's capsule closure. Methods: This is an experimental laboratory study and retrospective surgical case series. Histologic examination of Tenon's capsule was performed on permanently fixated human orbital specimens. Suture pull-out testing as a measure of tissue strength was performed on anterior and mid-posterior Tenon's capsule in nonfixated human cadaver orbits. A retrospective review of enucleations with primary orbital implant placement performed by the authors between 1998 and 2008 was conducted to determine the surgical outcomes of enucleation using closure of mid-posterior Tenon's capsule. Results: Histologic analysis showed the average thickness of mid-posterior Tenon's capsule to be 121% greater than that of the anterior portion (518 vs. 234 mu, p < 0.001). Suture pull-out strength was 84% higher in mid-posterior versus anterior Tenon's capsule (741 vs. 1298 g, p = 0.016). Of the 103 enucleations performed by the authors (54 with unwrapped silicone implants and 49 with unwrapped porous polyethylene), there were 2 cases (1.9%) of implant extrusion and 1 case (1%) of implant exposure. Conclusion: From a structural and biomechanical standpoint, mid-posterior Tenon's capsule is significantly thicker and stronger than anterior Tenon's capsule, theoretically providing a superior barrier to orbital implant exposure and extrusion after enucleation. C1 [Cho, Raymond I.; Elner, Victor M.] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA. [Elner, Victor M.] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. RP Cho, RI (reprint author), Brooke Army Med Ctr, Ophthalmol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM raymond.cho@amedd.army.mil NR 36 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHAL PLAST RECONS JI Ophthalmic Plast. Reconstr. Surg. PD NOV-DEC PY 2010 VL 26 IS 6 BP 462 EP 466 DI 10.1097/IOP.0b013e3181dac629 PG 5 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 682KL UT WOS:000284402300019 PM 20700075 ER PT J AU Heimbeck, MS Reardon, PJ Callahan, J Everitt, HO AF Heimbeck, Martin S. Reardon, Patrick J. Callahan, John Everitt, Henry O. TI Transmissive quasi-optical Ronchi phase grating for terahertz frequencies SO OPTICS LETTERS LA English DT Article ID DIFFRACTIVE OPTICS; MILLIMETER; DESIGN AB A transmissive, square-wave Ronchi phase grating has been fabricated from the dielectric polytetrafluoroethylene to diffract an similar to 0.7 THz beam quasi-optically. When illuminated by a coherent, cw terahertz (THz) source, the spot separation of the +/- 1 diffractive orders and the diffraction efficiency were measured as a function of THz frequency and rotation angle. The grating performance depends sensitively on the refractive index, whose value can be measured with an accuracy limited by the fabrication precision. The use of these gratings for polarization-insensitive quasi-optical imaging and phased arrays is discussed. (C) 2010 Optical Society of America C1 [Heimbeck, Martin S.; Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. [Reardon, Patrick J.] Univ Alabama, Ctr Appl Opt, Huntsville, AL 35899 USA. [Callahan, John] AEgis Technol Grp Inc, Huntsville, AL 35806 USA. RP Heimbeck, MS (reprint author), USA, Aviat & Missile RD&E Ctr, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. EM martin.heimbeck@us.army.mil RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU Test Resource Management Center (TRMC); U.S. Army Program Executive Office for Simulation, Training and Instrumentation (PEO STRI) [W900KK-09-C-0001] FX The authors thank J. Mait for a critical reading of this manuscript and the Test Resource Management Center (TRMC) Test and Evaluation/Science & Technology (T&E/S&E/S&T) Program for their support. This work was partially funded by the T&E/S&E/S&T Program through the U.S. Army Program Executive Office for Simulation, Training and Instrumentation (PEO STRI) contract number W900KK-09-C-0001. NR 11 TC 3 Z9 3 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD NOV 1 PY 2010 VL 35 IS 21 BP 3658 EP 3660 PG 3 WC Optics SC Optics GA 673IW UT WOS:000283653900041 PM 21042382 ER PT J AU Crane, CC AF Crane, Conrad C. TI Bombing Civilians: A Twentieth-Century History SO PACIFIC HISTORICAL REVIEW LA English DT Book Review C1 [Crane, Conrad C.] USA, War Coll, Washington, DC USA. RP Crane, CC (reprint author), USA, War Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI BERKELEY PA C/O JOURNALS & DIGITAL PUBLISHING DIVISION, 2000 CENTER ST, STE 303, BERKELEY, CA 94704-1223 USA SN 0030-8684 J9 PAC HIST REV JI Pac. Hist. Rev. PD NOV PY 2010 VL 79 IS 4 BP 669 EP U292 PG 3 WC History SC History GA 671GF UT WOS:000283487800025 ER PT J AU Gorman, G Neu, A Fivush, B Frankenfield, D Furth, S AF Gorman, Gregory Neu, Alicia Fivush, Barbara Frankenfield, Diane Furth, Susan TI Hospitalization rates and clinical performance measures in U.S. adolescent hemodialysis patients SO PEDIATRIC NEPHROLOGY LA English DT Article DE Hemodialysis; Pediatrics; Guidelines; Outcomes ID MORTALITY; TARGETS; OUTCOMES AB The Centers for Medicare and Medicaid Services' End Stage Renal Disease (ESRD) Clinical Performance Measures (CPM) Project monitors clinical measure attainment in pediatric hemodialysis (HD) patients. Targets include hemoglobin a parts per thousand yen11 g/dL, albumin a parts per thousand yen3.5/3.2 g/dL (bromcresol green/purple), single-pooled Kt/V a parts per thousand yen1.2, and the use of subcutaneous access. We hypothesized that the achievement of multiple targets by adolescent HD patients is associated with decreased morbidity. Data on patients aged 12-18 years included in the ESRD CPM Project from 2000 to 2004 with Medicare as primary payer were linked to the U.S. Renal Data System data from October 1, 1999 to December 31, 2004. Hospitalization rates by number of targets achieved were determined with Poisson regression analysis adjusted for dialysis vintage, short stature, and race. A total of 1534 patients with 1774 patient-years of follow-up, with 580 hospitalizations, were included in the analysis. In their first year in the ESRD CPM Project, 22% of the patients achieved four targets, with 34 and 28% achieving three and two targets, respectively. Subcutaneous access was least frequently attained target; spKt/V a parts per thousand yenaEuro parts per thousand 1.2 was the most frequently attained target. After adjustment, there was decreased hospitalization risk with increasing target attainment (incidence rate ratio 0.74, 95% confidence interval 0.67-0.80, p < 0.001). Based on this analysis, meeting adult-defined targets is associated with decreases in the hospitalization rate of adolescent HD patients. Tracking adult-defined HD measures is appropriate for assessing hospitalization risk in adolescent patients, although no evidence for a cause-and-effect relationship exists. C1 [Gorman, Gregory] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Gorman, Gregory] Natl Naval Med Ctr, Sect Pediat Nephrol, Walter Reed Army Med Ctr, Washington, DC USA. [Neu, Alicia; Fivush, Barbara; Furth, Susan] Johns Hopkins Med Inst, Div Pediat Nephrol, Baltimore, MD 21205 USA. [Frankenfield, Diane] Ctr Medicare & Medicaid Serv, Res & Evaluat Grp, Off Res Dev & Informat, Baltimore, MD USA. [Furth, Susan] Childrens Hosp Philadelphia, Div Nephrol, Philadelphia, PA 19104 USA. RP Gorman, G (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM ggorman@usuhs.mil FU National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland [R21 DK64313] FX This study was supported by grant R21 DK64313 from the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland. This study was presented at the American Society of Nephrology in Philadelphia, PA in October 2005 and at the American Society of Pediatric Nephrology meeting in San Francisco on April 30, 2006. NR 17 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PD NOV PY 2010 VL 25 IS 11 BP 2335 EP 2341 DI 10.1007/s00467-010-1597-8 PG 7 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA 648WN UT WOS:000281725200016 PM 20668886 ER PT J AU Yingling, P AF Yingling, Paul TI Critical Thinking and Its Discontents SO PERSPECTIVES ON POLITICS LA English DT Editorial Material C1 [Yingling, Paul] USA, Washington, DC 20310 USA. [Yingling, Paul] George C Marshall European Ctr Secur Studies, Program Terrorism & Secur Studies, Garmisch Partenkirchen, Germany. [Yingling, Paul] Univ Chicago, Chicago, IL 60637 USA. RP Yingling, P (reprint author), USA, Washington, DC 20310 USA. EM paul.yingling@us.army.mil NR 19 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 J9 PERSPECT POLIT JI Perspect. Polit. PD NOV PY 2010 VL 8 IS 4 BP 1117 EP 1121 DI 10.1017/S1537592710003257 PG 5 WC Political Science SC Government & Law GA 684TZ UT WOS:000284574500012 ER PT J AU Perez, C AF Perez, Celestino TI Empowering Our Military Conscience: Transforming Just War Theory and Military Moral Education. SO PERSPECTIVES ON POLITICS LA English DT Book Review C1 [Perez, Celestino] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Perez, C (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 J9 PERSPECT POLIT JI Perspect. Polit. PD NOV PY 2010 VL 8 IS 4 BP 1203 EP 1205 DI 10.1017/S1537592710003002 PG 4 WC Political Science SC Government & Law GA 684TZ UT WOS:000284574500045 ER PT J AU Bishop-Lilly, KA Turell, MJ Willner, KM Butani, A Nolan, NME Lentz, SM Akmal, A Mateczun, A Brahmbhatt, TN Sozhamannan, S Whitehouse, CA Read, TD AF Bishop-Lilly, Kimberly A. Turell, Michael J. Willner, Kristin M. Butani, Amy Nolan, Nichole M. E. Lentz, Shannon M. Akmal, Arya Mateczun, Al Brahmbhatt, Trupti N. Sozhamannan, Shanmuga Whitehouse, Chris A. Read, Timothy D. TI Arbovirus Detection in Insect Vectors by Rapid, High-Throughput Pyrosequencing SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID VIRUS-INFECTION; DENGUE-2 VIRUS; AEDES-AEGYPTI; GENOME; DIVERSITY; BACTERIUM; MICROBES; SEQUENCE; GENES AB Background: Despite the global threat caused by arthropod-borne viruses, there is not an efficient method for screening vector populations to detect novel viral sequences. Current viral detection and surveillance methods based on culture can be costly and time consuming and are predicated on prior knowledge of the etiologic agent, as they rely on specific oligonucleotide primers or antibodies. Therefore, these techniques may be unsuitable for situations when the causative agent of an outbreak is unknown. Methodology/Principal Findings: In this study we explored the use of high-throughput pyrosequencing for surveillance of arthropod-borne RNA viruses. Dengue virus, a member of the positive strand RNA Flavivirus family that is transmitted by several members of the Aedes genus of mosquitoes, was used as a model. Aedes aegypti mosquitoes experimentally infected with dengue virus type 1 (DENV-1) were pooled with noninfected mosquitoes to simulate samples derived from ongoing arbovirus surveillance programs. Using random-primed methods, total RNA was reverse-transcribed and resulting cDNA subjected to 454 pyrosequencing. Conclusions/Significance: In two types of samples, one with 5 adult mosquitoes infected with DENV-1- and the other with 1 DENV-1 infected mosquito and 4 noninfected mosquitoes, we identified DENV-1 DNA sequences. DENV-1 sequences were not detected in an uninfected control pool of 5 adult mosquitoes. We calculated the proportion of the Ae. aegypti metagenome contributed by each infecting Dengue virus genome (p(IP)), which ranged from 2.75x10(-8) to 1.08x10(-7). DENV-1 RNA was sufficiently concentrated in the mosquito that its detection was feasible using current high-throughput sequencing instrumentation. We also identified some of the components of the mosquito microflora on the basis of the sequence of expressed RNA. This included members of the bacterial genera Pirellula and Asaia, various fungi, and a potentially uncharacterized mycovirus. C1 [Bishop-Lilly, Kimberly A.; Willner, Kristin M.; Butani, Amy; Nolan, Nichole M. E.; Lentz, Shannon M.; Akmal, Arya; Mateczun, Al; Brahmbhatt, Trupti N.; Sozhamannan, Shanmuga; Read, Timothy D.] USN, Biol Def Res Directorate, Med Res Ctr, Silver Spring, MD USA. [Turell, Michael J.; Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bishop-Lilly, KA (reprint author), USN, Biol Def Res Directorate, Med Res Ctr, Silver Spring, MD USA. EM Kim.bishop-lilly@med.navy.mil RI Read, Timothy/E-6240-2011 FU Defense Threat Reduction Agency (DTRA) [G.G.0004_06_NM_B] FX Funding was provided by Defense Threat Reduction Agency (DTRA; www.dtra.mil) for project G.G.0004_06_NM_B to T. D. Read. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 40 TC 28 Z9 29 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD NOV PY 2010 VL 4 IS 11 AR e878 DI 10.1371/journal.pntd.0000878 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 687GB UT WOS:000284765900020 PM 21085471 ER PT J AU Sacquety, TJ AF Sacquety, Troy J. TI OSS Training in the National Parks and Service Abroad in World War II SO PUBLIC HISTORIAN LA English DT Book Review C1 [Sacquety, Troy J.] USA, Hist Off, Special Operat Command, Washington, DC 20310 USA. RP Sacquety, TJ (reprint author), USA, Hist Off, Special Operat Command, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI BERKELEY PA C/O JOURNALS & DIGITAL PUBLISHING DIVISION, 2000 CENTER ST, STE 303, BERKELEY, CA 94704-1223 USA SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD NOV PY 2010 VL 32 IS 4 BP 157 EP 159 DI 10.1525/tph.2010.32.4.157 PG 4 WC History SC History GA 695YF UT WOS:000285408100027 ER PT J AU Cohn, SM Blackbourne, LH Landry, DW Proctor, KG Walley, KR Wenzel, V AF Cohn, Stephen M. Blackbourne, Lorne H. Landry, Donald W. Proctor, Kenneth G. Walley, Keith R. Wenzel, Volker TI San Antonio Vasopressin in Shock Symposium Report SO RESUSCITATION LA English DT Article DE Conference report; Vasopressin; Shock; Cardiac arrest; Traumatic brain injury; Septic shock; Haemorrhagic shock ID HEMORRHAGIC-SHOCK; CARDIOPULMONARY-RESUSCITATION; ARGININE-VASOPRESSIN; SEPTIC SHOCK; EPINEPHRINE; MANAGEMENT; SURVIVAL; INFUSION; CARE AB The San Antonio Vasopressin Symposium reviewed substantial accumulated data concerning vasopressin in haemorrhagic, septic, and cardiac arrest shock conditions and found that there is considerable evidence to support the use of vasopressin in overcoming vasopressin deficiency or insufficiency. The value of vasopressin in the setting of trauma requires further investigation. It was concluded that a large, multicenter controlled trial of vasopressin is needed to assess the therapeutic benefit of vasopressin replacement in the setting of trauma with haemorrhagic shock that is prolonged and profound. (c) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Wenzel, Volker] Innsbruck Med Univ, Dept Anesthesiol & Crit Care Med, A-6020 Innsbruck, Austria. [Cohn, Stephen M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Landry, Donald W.] Columbia Univ, New York, NY USA. [Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Walley, Keith R.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. RP Wenzel, V (reprint author), Innsbruck Med Univ, Dept Anesthesiol & Crit Care Med, Anichstr 35, A-6020 Innsbruck, Austria. EM volker.wenzel@uki.at FU University of Texas Health Sciences Center, Department of Surgery; U.S. Army Institute of Surgical Research, San Antonio, Texas FX The meeting was sponsored by the University of Texas Health Sciences Center, Department of Surgery, and the U.S. Army Institute of Surgical Research, San Antonio, Texas. NR 20 TC 5 Z9 5 U1 1 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD NOV PY 2010 VL 81 IS 11 BP 1473 EP 1475 DI 10.1016/j.resuscitation.2010.06.005 PG 3 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 692BQ UT WOS:000285126900006 PM 20655650 ER PT J AU Nussenblatt, RB Byrnes, G Sen, HN Yeh, S Faia, L Meyerle, C Wroblewski, K Li, ZQ Liu, BY Chew, E Sherry, PR Friedman, P Gill, F Ferris, F AF Nussenblatt, Robert B. Byrnes, Gordon Sen, H. Nida Yeh, Steven Faia, Lisa Meyerle, Catherine Wroblewski, Keith Li, Zhuqing Liu, Baoying Chew, Emily Sherry, Patti R. Friedman, Penelope Gill, Fred Ferris, Frederick, III TI A RANDOMIZED PILOT STUDY OF SYSTEMIC IMMUNOSUPPRESSION IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION WITH CHOROIDAL NEOVASCULARIZATION SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES LA English DT Article DE age-related macular degeneration; immunosuppression; T cell; choroidal neovascularization ID RAPAMYCIN; THERAPY; SUSCEPTIBILITY; INFLAMMATION; SIROLIMUS; UVEITIS; VARIANT; ALPHA; CELLS; HTRA1 AB Background: Age-related macular degeneration remains the leading cause of irreversible blindness in the United States and the developed world. Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications have become standard of care for the treatment of the wet form of the disease. Recent reports have demonstrated an association with various immune factors. We aimed to investigate the effect of immunosuppressive therapy in the clinical course of the wet form of the disease. We compared anti-VEGF therapy plus one of three systemic immunosuppressive therapies versus anti-VEGF therapy alone for recurrent choroidal neovascularization associated with age-related macular degeneration. Methods: This was a pilot, Phase I/II, prospective, randomized, unmasked, single-center trial. Patients with subretinal exudation secondary to recurrent choroidal neovascularization associated with age-related macular degeneration were included in the study. Patients were randomized to 1 of 3 systemic arms immunosuppressive agents (daclizumab, rapamycin, or infliximab) for 6 months plus intraocular anti-VEGF therapy if indicated, compared with a group who received only anti-VEGF therapy if indicated. Results: The number of anti-VEGF injections per group, visual acuity, retinal thickness, and safety measures were assessed in all groups. Thirteen patients were randomized; comparing anti-VEGF injections before and during the study, a decrease in the number of injections from 0.73 injections per month to 0.42 for daclizumab and from 0.67 to 0.34 for sirolimus was seen, while no apparent decrease was seen for either infliximab or observation. Visual acuities were maintained in all groups. Conclusion: These preliminary data suggest that some immunosuppressive agents given systemically can alter the clinical course of the wet form of the disease and support the notion that more definitive clinical trials of immune mediation of age-related macular degeneration are indicated. RETINA 30:1579-1587, 2010 C1 [Nussenblatt, Robert B.] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA. [Byrnes, Gordon] Retina Grp Washington, Fairfax, VA USA. [Wroblewski, Keith] Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC USA. [Gill, Fred] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Nussenblatt, RB (reprint author), NEI, Immunol Lab, NIH, Bldg 10,Room 10N112,10 Ctr Dr, Bethesda, MD 20892 USA. EM drbob@nei.nih.gov FU National Eye Institute, National Institutes of Health, Bethesda, Maryland FX Supported by intramural funds of the National Eye Institute, National Institutes of Health, Bethesda, Maryland. NR 29 TC 37 Z9 38 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0275-004X J9 RETINA-J RET VIT DIS JI Retin.-J. Retin. Vitr. Dis. PD NOV-DEC PY 2010 VL 30 IS 10 BP 1579 EP 1587 DI 10.1097/IAE.0b013e3181e7978e PG 9 WC Ophthalmology SC Ophthalmology GA 678HL UT WOS:000284064600004 PM 20847709 ER PT J AU Todd, CS Nasir, A Stanekzai, MR Abed, AMS Strathdee, SA Bautista, CT Scott, PT Botros, BA Tjaden, J AF Todd, Catherine S. Nasir, Abdul Stanekzai, Mohammad Raza Abed, Abdullah M. S. Strathdee, Steffanie A. Bautista, Christian T. Scott, Paul T. Botros, Boulos A. Tjaden, Jeffrey TI Prevalence and Correlates of Syphilis and Condom Use Among Male Injection Drug Users in Four Afghan Cities SO SEXUALLY TRANSMITTED DISEASES LA English DT Article; Proceedings Paper CT 17th International AIDS Conference CY AUG 03-08, 2008 CL Mexico City, MEXICO ID SEXUALLY-TRANSMITTED INFECTIONS; FEMALE SEX WORKERS; RISK BEHAVIORS; HEPATITIS-B; HIV-INFECTION; PAKISTAN; KABUL; INDIA; TRANSMISSION; PREVENTION AB Background: Injecting drug use is increasing in Afghanistan but little is known about sexual risk behaviors and sexually transmitted infection (STI) prevalence among injection drug users (IDU). The purpose of this study is to assess prevalence and correlates of syphilis and condom use with female sex workers (FSWs) among male IDUs in Hirat, Jalalabad, Kabul, and Mazar-i-Sharif, Afghanistan. Methods: Participants in this cross-sectional study completed an interviewer-administered questionnaire and serologic testing for syphilis between June 2005 and January 2008. Factors associated with syphilis condom use with FSWs were assessed with site-controlled logistic regression analysis. Results: Of 1078 male IDUs, most (90.3%) reported prior sexual experience, of whom 27.6% reported any condom use. Sexual experiences with FSWs (58.1%) and men or boys (25.7%) were common, although prior condom use with FSWs (32.6%) or male partners (10.8%) was relatively rare. Few reported having a lifetime STI diagnosis (6.3%, n = 68) or symptoms (10.4%, n = 110) in the last 6 months. Prevalence of syphilis was 3.72% (95% CI: 2.66%-5.06%) and varied significantly between sites ranging from 0% (Jalalabad) to 13.9% (Mazar-i-Sharif) (P < 0.001). Syphilis was significantly associated with STI diagnosis (adjusted odds ratio [AOR] = 3.84) or sex with FSWs (AOR = 3.82) in the last 6 months, and with lower (<= 6 years) educational level (AOR = 2.20). Prior condom use with FSWs was independently associated with living outside Afghanistan in the last decade (AOR = 5.52, 95% CI: 1.83-16.71), higher income (AOR = 2.03, 95% CI: 1.17-3.51), greater number of lifetime partners (AOR = 1.80, 95% CI: 1.32-2.45), and younger age (AOR = 0.985, 95% CI: 0.973-0.998). Conclusions: Although prevalence of syphilis and condom use varied significantly by site, high levels of risky sexual behavior were common, and consistent condom use was rare among IDUs in Afghanistan. Harm reduction programming should incorporate sexual risk reduction and condom promotion and distribution in Afghan cities. C1 [Todd, Catherine S.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10032 USA. [Nasir, Abdul; Stanekzai, Mohammad Raza] Int Rescue Comm, Kabul, Afghanistan. [Abed, Abdullah M. S.] Natl HIV AIDS Control Program, Minist Publ Hlth, Kabul, Afghanistan. [Strathdee, Steffanie A.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. [Bautista, Christian T.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Botros, Boulos A.; Tjaden, Jeffrey] USN, Med Res Unit 3, Cairo, Egypt. RP Todd, CS (reprint author), Columbia Univ, Dept Obstet & Gynecol, PH 16-69,622 West 168th St, New York, NY 10032 USA. EM cst2121@columbia.edu RI Bautista, Christian/B-2812-2011 FU FIC NIH HHS [K01TW007408] NR 35 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD NOV PY 2010 VL 37 IS 11 BP 719 EP 725 DI 10.1097/OLQ.0b013e3181e2c76a PG 7 WC Infectious Diseases SC Infectious Diseases GA 671FY UT WOS:000283487100010 PM 20585276 ER PT J AU Rupp, TL Killgore, WDS Balkin, TJ AF Rupp, Tracy L. Killgore, William D. S. Balkin, Thomas J. TI Socializing by Day May Affect Performance by Night: Vulnerability to Sleep Deprivation is Differentially Mediated by Social Exposure in Extraverts vs Introverts SO SLEEP LA English DT Article DE Sleep deprivation; personality; extraversion; waking experience ID INTERINDIVIDUAL DIFFERENCES; MORNINGNESS-EVENINGNESS; INDIVIDUAL-DIFFERENCES; PSYCHOMOTOR VIGILANCE; BRAIN RESPONSES; PERSONALITY; DROSOPHILA; TRAIT; WAKEFULNESS; HOMEOSTASIS AB Study Objectives: To examine the effects of socially enriched versus socially impoverished environments on performance and alertness decline during sleep deprivation in extraverts versus introverts. Design: Participants (n = 29 men, n = 19 women) were assigned to socially enriched (n = 24; 13 introverts, 11 extraverts) or socially impoverished (n = 24; 12 introverts, 12 extraverts) conditions (activities matched) for 12 hours (1000-2200) on Day 1 followed by 22 hours of sleep deprivation (2200-2000; 36 h awake total), monitored by actigraphy. The median split of volunteers' Eysenck Extraversion scores was used for extravert/introvert categorization. The Psychomotor Vigilance Task (PVT), modified Maintenance of Wakefulness Test (MWT), and Stanford Sleepiness Scale (SSS) were administered every 2 hours throughout. PVT speed, transformed lapses, modified MWT sleep-onset latency, and SSS were analyzed using mixed-model analyses of variance, with covariates of age and total actigraphic activity during enrichment or impoverishment. Setting: Residential sleep/performance testing facility. Participants: Forty-eight healthy adults (aged 18-39). Interventions: Twelve hours of socially enriched or isolated environments in extraverts and introverts prior to sleep deprivation. Results: Social experience interacted with personality type to affect alertness and vigilance. Social enrichment, as compared with social impoverishment, was associated with more PVT lapses at 04:00 overall. Similarly, following social enrichment, PVT speed was significantly slower among extraverts than among introverts during sleep deprivation, but no personality-group differences emerged following social impoverishment. MWT sleep latency and SSS subjective sleepiness did not show significant personality or social-condition effects during sleep deprivation. Conclusions: The effect of social exposure on vulnerability or resiliency to sleep deprivation was modulated by introversion and extraversion. Extraverts exposed to social environments were more vulnerable to subsequent sleep deprivation than were introverts. C1 [Rupp, Tracy L.] Walter Reed Army Inst Res, Dept Behav Biol, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Rm 2w88,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defense. NR 58 TC 14 Z9 14 U1 2 U2 14 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD NOV 1 PY 2010 VL 33 IS 11 BP 1475 EP 1485 PG 11 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 693GM UT WOS:000285212600011 PM 21102989 ER PT J AU Das, NC AF Das, Naresh C. TI Infrared light emitting device with two color emission SO SOLID-STATE ELECTRONICS LA English DT Article DE MWIR LEDs; LWIR LEDs; Interband cascade; Cryogenic operation ID DIODES AB We have designed and fabricated two-color infrared light emitting diode (LED) emitting in the wavelength regions of 3-4 mu m and 5-10 mu m. The interband cascade (IC) LED device was grown on n-type GaSb substrate and has 30 cascaded stages for the long-wave infrared (LWIR) and 15 cascaded stages for the mid-wave infrared (MWIR) emission bands. The two active regions are separated by a 0.5 mu m thick contact layer, which is used for biasing the two LEDs. Both room temperature and cryogenic temperature results show emission in the wavelength regions as designed. Published by Elsevier Ltd. C1 Army Res Lab, Adelphi, MD 20783 USA. RP Das, NC (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM naresh.das@us.army.mil NR 12 TC 2 Z9 2 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD NOV PY 2010 VL 54 IS 11 BP 1381 EP 1383 DI 10.1016/j.sse.2010.06.007 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 644DC UT WOS:000281350600023 ER PT J AU Nobthai, P Serichantalergs, O Wongstitwilairoong, B Srijan, A Bodhidatta, L Malla, S Mason, CJ AF Nobthai, Panida Serichantalergs, Oralak Wongstitwilairoong, Boonchai Srijan, Apichai Bodhidatta, Ladaporn Malla, Sarala Mason, Carl J. TI EMERGENCE AND PROPERTIES OF FLUOROQUINOLONE RESISTANT SALMONELLA ENTERICA SEROVAR TYPHI STRAINS ISOLATED FROM NEPAL IN 2002 AND 2003 SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Salmonella enterica serovar Typhi; antimicrobial resistances; quinolone resistance; typhoid outbreak; Nepal ID QUINOLONE RESISTANCE; PARATYPHI-A; MUTATIONS; GYRA; SUSCEPTIBILITY; CIPROFLOXACIN; MECHANISMS; GENES; FEVER; PARC AB A total of 171 Salmonella enterica serovar Typhi strains isolated from Nepal, mostly from patients with typhoid fever in 2002-2003, were tested for antimicrobial susceptibility by disk diffusion assay Selected S enterica serovar Typhi isolates were tested for MICs by E-test for ceftriaxone, ciprofloxacin and ofloxacin Mutations of DNA gyrase gyrA and gyrB and topoisomerase IV parC and parE were identified by sequencing of PCR amplicons By disk diffusion assay, 757171 S enterica serovar Typhi isolates were resistant to nalidixic acid, ampicillin, choramphenicol, streptomycin, tetracycline, sulfisoxazole, and trimethroprim/sulfamethoxazoles Multiple drug resistance to the 7 antimicrobials was most predominant among S enterica serovar Typhi isolates in this study Resistance to nalidixic acid was detected in 76/111 and 56/60 of total isolates collected in 2002 and 2003, respectively Nalidixic acid-resistant isolates in 2002 and 2003 showed MIC range for ciprofloxacin of 0 125-0 250 mg/l Nalidixic acid-resistant isolates contained point mutations in gyrA and parC but not gyrB and parE The gyrA mutation of nalidixic acid-resistant isolates obtained in 2002 and 2003 had amino acid substitution at position 83 of Serine -> Tyrosine and Serine -> Phenylalanine, respectively Two different mutations of gyrA were detected among nalidixic acid-resistant isolates Thus it is necessary to monitor mutation in DNA topoisomerase associated with increases in quinolones resistance C1 [Nobthai, Panida; Serichantalergs, Oralak; Wongstitwilairoong, Boonchai; Srijan, Apichai; Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Malla, Sarala] Natl Publ Hlth Lab, Kathmandu, Nepal. RP Nobthai, P (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. OI MASON, CARL/0000-0002-3676-2811 FU National Public Health Laboratory, Nepal; US Department of Defense Global Emerging Infectious Surveillance and Response System FX We were grateful to staff of the Enteric Diseases Department, AFRIMS for bacterial identification and archiving of bacteria We thank the staff of Bharatpur Hospital, Bharatpur and College of Medical Sciences, Bharatpur, Nepal Without their assistance, the collection of samples from outbreaks could not have been possible We also would like to thank the staff of antimicrobial resistance program of the National Public Health Laboratory, Nepal for providing necessary support This study was supported by the US Department of Defense Global Emerging Infectious Surveillance and Response System NR 17 TC 3 Z9 4 U1 0 U2 0 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2010 VL 41 IS 6 BP 1416 EP 1422 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 687PT UT WOS:000284791100020 PM 21329318 ER PT J AU Bland, CM Porr, WH Davis, KA Mansell, KB AF Bland, Christopher M. Porr, William H. Davis, Kepler A. Mansell, Karon B. TI Vancomycin MIC Susceptibility Testing of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Isolates: A Comparison Between Etest (R) and an Automated Testing Method SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE Etest; MIC; MRSA; MSSA; vancomycin ID MINIMUM INHIBITORY CONCENTRATION; BACTEREMIA; INFECTIONS; THERAPY; GLYCOPEPTIDES; HEMODIALYSIS; EFFICACY; FAILURE; GENE AB Background: Vancomycin treatment failures and increased mortality have been reported in methicillin-resistant Staphylococcus aureus (MRSA) isolates with minimum inhibitory concentrations (MICs) >1 mu g/mL. Most of this data utilized manual testing to determine the MIC. Recent vancomycin treatment guidelines do not specify the optimal testing method to define the MIC. Methods: Over a twelve-month study period, we compared manual susceptibility testing by Etest (R) (AB Biodisk, Solna, Sweden) with automated testing by MicroScan Walk-Away (R) (Dade Behring, Inc., East Mississauga, Ontario) to determine the difference in the MICs among 383 sequential clinical S aureus isolates. Results: Manual testing demonstrated MICs of 1.5 mu g/mL or 2.0 mu g/mL in 90% and 86% of MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) isolates, respectively. Automated testing revealed MICs of 2.0 mu g/mL for 56% and 54% of MRSA and MSSA isolates, respectively. The manual MIC test by Etest (R) was >1 mu g/mL in 87% of MRSA isolates and 86% of methicillin-susceptible S aureus isolates in which the automated MIC result was 1 mu g/mL. This same finding occurred in 94% (17/18) of S aureus isolates causing non-skin/skin structure infections. Among all subgroups of isolates, manual testing demonstrated statistically significant higher MICs compared to automated testing. Conclusions: MIC results generated by the Etest (R) consistently revealed a one dilution higher vancomycin MIC compared to MicroScan (R). Automated MIC results of invasive MRSA isolates should be confirmed by manual Etest (R) to ensure identification of those isolates with vancomycin MICs >1 mu g/mL that are at risk for vancomycin treatment failure or increased mortality. C1 [Bland, Christopher M.] Dwight Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA 30905 USA. Dwight Eisenhower Army Med Ctr, Dept Med Infect Dis, Ft Gordon, GA 30905 USA. Dwight Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA. Dwight Eisenhower Army Med Ctr, Area Lab Serv, Ft Gordon, GA 30905 USA. RP Bland, CM (reprint author), Dwight Eisenhower Army Med Ctr, Dept Clin Pharm, Bldg 300,E Hosp Rd, Ft Gordon, GA 30905 USA. EM chris.bland@us.army.mil NR 23 TC 16 Z9 17 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD NOV PY 2010 VL 103 IS 11 BP 1124 EP 1128 DI 10.1097/SMJ.0b013e3181efb5b1 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 674EH UT WOS:000283716400011 PM 20890258 ER PT J AU Cardoso, MJ Dmitriev, AE Helgeson, MD Paik, H Mendelsohn, AK Lehman, RA Rosner, MK AF Cardoso, Mario J. Dmitriev, Anton E. Helgeson, Melvin D. Paik, Haines Mendelsohn, Audra K. Lehman, Ronald A., Jr. Rosner, Michael K. TI Does catastrophic midline failure of upper thoracic lamina screws violate the spinal canal? A cadaveric biomechanical analysis using two lamina screw techniques SO SPINE JOURNAL LA English DT Article DE Lamina screw; Midline failure; Thoracic spine; Biomechanic; Cadaver ID BONE-MINERAL DENSITY; COMPUTED-TOMOGRAPHY; STRAIGHT-FORWARD; PULLOUT STRENGTH; PEDICLE SCREWS; FIXATION; PLACEMENT; SALVAGE; INSTRUMENTATION; VERTEBRAE AB BACKGROUND CONTEXT: Lamina screws have been reported to be a biomechanically sound alternative to pedicle screws in the proximal thoracic spine. However, concerns have been raised that midline failure may result in a spinal canal breach. PURPOSE: To evaluate the catastrophic failure of proximal thoracic lamina screws using two techniques for lamina screw purchase. STUDY DESIGN: Biomechanical study with human cadaveric vertebrae. PATIENT SAMPLE: Not applicable. OUTCOME MEASURES: Not applicable. METHODS: Nineteen fresh-frozen T1-T2 vertebrae were Dual energy X-ray absorptiometry scanned for bone mineral density. Caliper measurements of lamina thickness and lateral mass width for bicortical purchase were obtained. Ten specimens had right-to-left 26-mm lamina screws inserted entirely within the length of the lamina (unicortical). Nine specimens had right-to-left 42-mm lamina screws inserted as to extend the length of the lamina and breach the cortex behind the first and second ribs (bicortical). All screws were placed by experienced spine surgeons under fluoroscopic visualization using 4.5-mm cervicothoracic screws. Insertional torque was recorded while placing all implants and reported in "in-lbs." Tensile loading to failure was performed with the force oriented in the parasagittal plane along the vertebral midline. Pullout loading was applied at a rate of 0.25 mm/s using an MTS 858 MiniBionix II System (MTS Systems, Inc., Minneapolis, MN, USA) with the maximum pullout strength (POS) recorded in Newtons. Video fluoroscopy was performed during midline pullout to evaluate screw failure and ascertain spinal canal breach. After testing. all specimens were visually inspected for spinal canal breach. RESULTS: Neither the unicortical nor the bicortical lamina screws violated the spinal canal during catastrophic midline failure. The ventral lamina cortex remained intact for both the lamina screw techniques. All of the unicortical lamina screws resulted in dorsal avulsion of the spinous process and lamina. All nine bicortical lamina screws separated the dorsal lamina from the ventral but were able to maintain lateral mass purchase. The peak insertional torque for both lamina screw techniques was not significantly different (p=.20). However, bicortical lamina screw POS (584.8 +/- 150.2 N) was significantly greater than unicortical lamina screw POS (455.6 +/- 100.2 N) (p=.04). Bone mineral density showed a moderate correlation with unicortical (r=0.67) and bicortical (r=0.47) lamina screw POS. CONCLUSION: Our results suggest that catastrophic midline failure of lamina screws does not violate the spinal canal. Of the two techniques tested, bicortical lamina screws have a biomechanical advantage. Lamina screws present a viable option for instrumenting the proximal thoracic spine. Published by Elsevier Inc. C1 [Dmitriev, Anton E.; Helgeson, Melvin D.; Paik, Haines; Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Dept Surg, Washington, DC 20307 USA. [Mendelsohn, Audra K.] Uniformed Hlth Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Paik, H (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM haines.paik@gmail.com NR 22 TC 1 Z9 1 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD NOV PY 2010 VL 10 IS 11 BP 1007 EP 1013 DI 10.1016/j.spinee.2010.07.393 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 680RJ UT WOS:000284251800009 PM 20851059 ER PT J AU Hall, JB Ellner, PM Mosleh, A AF Hall, J. Brian Ellner, Paul M. Mosleh, Ali TI Reliability Growth Management Metrics and Statistical Methods for Discrete-Use Systems SO TECHNOMETRICS LA English DT Article DE Discrete; Growth potential; Management metrics; Projection; Reliability growth ID ONE-SHOT SYSTEMS; WEIBULL PROCESS; PARAMETERS; MODEL AB In this article we present new methodology for analyzing reliability growth of discrete-use systems (i.e., systems whose test duration is measured in terms of discrete trials, shots, or demands). The methodology is applicable to the case where corrective actions are applied to prototypes anytime after associated failure modes are first discovered. Thus, the system configuration need not be constant. The methodology consists of several model equations for estimating: system reliability; the expected number of failure modes observed during testing; the probability of failure due to a new failure mode, and the portion of system unreliability associated with repeat, or known, failure modes. These model equations are used to: (1) estimate the initial and projected reliability as well as the reliability growth potential; (2) address model goodness-of-fit concerns; (3) quantify programmatic risk; and (4) assess reliability maturity of discrete-use systems undergoing development. Statistical procedures for point estimation, confidence interval construction, and goodness-of-fit testing are also given. In particular. a new likelihood function (and associated maximum likelihood procedure) is derived to estimate model parameters, that is, the shape parameters of the beta distribution. An application to a missile program is given to illustrate the utility of the presented approach. Supplemental materials for this article are available on the Technometrics website. C1 [Hall, J. Brian] USA, Test & Evaluat Command, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. [Ellner, Paul M.] US AMSAA, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. [Mosleh, Ali] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Hall, JB (reprint author), USA, Test & Evaluat Command, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. EM brian.hall@us.army.mil; paul.m.ellner@us.army.mil; mosleh@umd.edu NR 32 TC 5 Z9 5 U1 0 U2 9 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA SN 0040-1706 J9 TECHNOMETRICS JI Technometrics PD NOV PY 2010 VL 52 IS 4 BP 379 EP 389 DI 10.1198/TECH.2010.08068 PG 11 WC Statistics & Probability SC Mathematics GA 698BB UT WOS:000285565400002 ER PT J AU Hall, JB Ellner, PM Mosleh, A AF Hall, J. Brian Ellner, Paul M. Mosleh, Ali TI Untitled SO TECHNOMETRICS LA English DT Editorial Material ID RELIABILITY-GROWTH; MODELS; SOFTWARE C1 [Hall, J. Brian] USA, Test & Evaluat Command, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. [Ellner, Paul M.] US AMSAA, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. [Mosleh, Ali] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Hall, JB (reprint author), USA, Test & Evaluat Command, US Dept Def, Aberdeen Proving Ground, MD 21005 USA. EM brian.hall@us.army.mil; paul.m.ellner@us.army.mil; mosleh@umd.edu NR 8 TC 0 Z9 0 U1 0 U2 2 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA SN 0040-1706 J9 TECHNOMETRICS JI Technometrics PD NOV PY 2010 VL 52 IS 4 BP 401 EP 408 DI 10.1198/TECH.2010.10103 PG 8 WC Statistics & Probability SC Mathematics GA 698BB UT WOS:000285565400008 ER PT J AU O'Donnell, JC Acon-Chen, C McDonough, JH Shih, TM AF O'Donnell, John C. Acon-Chen, Cindy McDonough, John H. Shih, Tsung-Ming TI Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholine; acetylcholinesterase; cholinesterase inhibitors; cyclosarin; in vivo microdialysis; lethality; nerve agents; organophosphorus compounds; seizure activity; tabun ID SOMAN-INDUCED SEIZURES; ATROPINE SULFATE; BLOOD; EFFICACY; BARRIER; MICRODIALYSIS; REACTIVATION; HIPPOCAMPUS; MECHANISMS; CORTEX AB Organophosphorus nerve agents like cyclosarin and tabun are potent cholinesterase inhibitors. The inhibition of acetylcholinesterase, which is responsible for breaking down acetylcholine (ACh) at the synapse and neuromuscular junction, leads to a build-up of extracellular ACh and a series of toxic consequences including hypersecretion, tremor, convulsion/seizure, respiratory distress, coma, and death. This study employed simultaneous and continuous electroencephalographic recording and striatal microdialysis collection for quantification of ACh changes (via subsequent HPLC analysis) during acute exposure to a 1.0 x LD(50) subcutaneous dose of either cyclosarin or tabun to investigate differences in cholinergic and behavioral effects. Information about the unique mechanisms and consequences of different nerve agents is intended to aid in the development of broad-spectrum medical countermeasures for nerve agents. At the dose administered, non-seizure and sustained seizure responses were observed in both agent groups and in the tabun-exposed group some subjects experienced an unsustained seizure response. Significant extracellular ACh increases were only observed in seizure groups. Cyclosarin and tabun were found to exhibit some unique cholinergic and ictogenic characteristics. Lethality only occurred in subjects experiencing sustained seizure, and there was no difference in lethality between agent groups that progressed to sustained seizure. C1 [Shih, Tsung-Ming] USA, Med Res Inst Chem Def, Pharmacol Branch, Div Res,ATTN MCMR CDR P, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, Pharmacol Branch, Div Res,ATTN MCMR CDR P, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil FU Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division FX This research was supported by the Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division. The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of the paper. NR 36 TC 4 Z9 4 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD NOV PY 2010 VL 20 IS 9 BP 600 EP 608 DI 10.3109/15376516.2010.521208 PG 9 WC Toxicology SC Toxicology GA 668ZA UT WOS:000283314300011 PM 20919801 ER PT J AU Rice, K Hudak, J Peay, K Elsamanoudi, S Travis, J Lockhart, R Cullen, J Black, L Houge, S Brassell, S AF Rice, Kevin Hudak, Jane Peay, Kimberly Elsamanoudi, Sally Travis, Judith Lockhart, Robbin Cullen, Jennifer Black, Libby Houge, Susan Brassell, Stephen TI Comprehensive Quality-of-life Outcomes in the Setting of a Multidisciplinary, Equal Access Prostate Cancer Clinic SO UROLOGY LA English DT Article ID EXPECTATIONS; MANAGEMENT AB OBJECTIVES To identify racial and demographic factors that influence treatment choice and its resulting impact on health-related quality of life (HRQoL) for prostate cancer patients. METHODS Patients presenting to an equal access, military, multidisciplinary prostate cancer clinic composed the study group. The Expanded Prostate Cancer Index Composite (EPIC), EPIC Demographic, and Medical Outcomes Study Short Form 36 were the instruments used. Evaluation was performed before treatment and every 3 months after treatment. RESULTS The study group comprised 665 patients. Caucasians were 3-fold more likely to choose surgery (radical prostatectomy [ RP]) over external beam radiation therapy (EBRT). Patients who earned more than $100 000 annually disproportionately chose RP (P < .0001). Similarly, those having a graduate school degree disproportionally chose RP (P < .0001). Patients undergoing RP had the greatest risk of urinary function decline (P < .0001) and sexual bother (P = .0003). African Americans (AA) had a greater risk of urinary function decline irrespective of treatment choice. Patients undergoing EBRT had equivalent urinary function to expectant management (EM) at 12 months (P < .0001). Brachytherapy was the only treatment that posed an increased risk of urinary bother decline when compared with EM (P = .0217). EBRT alone did not show significant decrement in sexual function when compared with EM. CONCLUSIONS RP was chosen by patients of Caucasian ethnicity and patients with higher income and education level, despite providing the greatest risk of HRQoL decline. EBRT had no significant impact on urinary function, sexual function, or sexual bother scores at 12 months. EBRT may be offered to older patients with minimal HRQoL impact. Pretreatment counseling of HRQoL outcomes is essential to overall prostate cancer management. UROLOGY 76: 1231-1239, 2010. Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. Ctr Prostate Dis Res, Washington, DC USA. GlaxoSmithKline Inc, Res Triangle Pk, NC USA. RP Rice, K (reprint author), 6900 Georgia Ave NW,Bldg 2,Ward 56, Washington, DC 20307 USA. EM Kevin.rice@amedd.army.mil NR 15 TC 14 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD NOV PY 2010 VL 76 IS 5 BP 1231 EP 1238 DI 10.1016/j.urology.2010.03.087 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 675QD UT WOS:000283844600059 PM 20579698 ER PT J AU Rice, K Brassell, S Hudak, J Peay, K Elsamanoudi, S Travis, J Lockhart, R Cullen, J Brassell, S Black, L Houge, S AF Rice, Kevin Brassell, Stephen Hudak, Jane Peay, Kimberly Elsamanoudi, Sally Travis, Judith Lockhart, Robbin Cullen, Jennifer Brassell, Stephen Black, Libby Houge, Susan TI Comprehensive Quality-of-life Outcomes in the Setting of a Multidisciplinary, Equal Access Prostate Cancer Clinic REPLY SO UROLOGY LA English DT Editorial Material C1 [Rice, Kevin; Brassell, Stephen] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Hudak, Jane; Peay, Kimberly; Elsamanoudi, Sally; Travis, Judith; Lockhart, Robbin; Cullen, Jennifer; Brassell, Stephen] Ctr Prostate Dis Res, Washington, DC USA. [Black, Libby; Houge, Susan] GlaxoSmithKline Inc, Res Triangle Pk, NC USA. RP Rice, K (reprint author), Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD NOV PY 2010 VL 76 IS 5 BP 1238 EP 1239 DI 10.1016/j.urology.2010.04.014 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 675QD UT WOS:000283844600061 ER PT J AU Hawksworth, JS Fitzgerald, D Speir, A Mukherjee, D AF Hawksworth, Jason S. Fitzgerald, Dave Speir, Alan Mukherjee, Dipankar TI Percutaneous In Situ Oxygenated Pump Perfusion of a Transplanted Kidney during Abdominal Aortic Aneurysm Repair SO VASCULAR LA English DT Article DE abdominal aortic aneurysm; kidney transplant; pump perfusion ID RENAL-TRANSPLANT; METABOLIC SYNDROME; ALLOGRAFT AB The surgical management of aortic aneurysms in kidney transplant patients is a difficult clinical scenario where preservation of the kidney allograft during aortic cross-clamping is paramount. We describe a novel technique for renal protection during abdominal aortic aneurysm repair with in situ oxygenated pump perfusion of the transplanted kidney. A percutaneous approach is used for common femoral artery and vein cannulation and a cardiopulmonary bypass circuit to provide retrograde oxygenated pump perfusion to the transplanted kidney. This technique allows adequate kidney perfusion during warm ischemia and minimizes morbidity by using a percutaneous access technique. C1 [Fitzgerald, Dave; Speir, Alan; Mukherjee, Dipankar] Cardiac Vasc & Thorac Surg Associates, Inova Fairfax Hosp, Falls Church, VA 22042 USA. [Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Mukherjee, D (reprint author), Cardiac Vasc & Thorac Surg Associates, Inova Fairfax Hosp, 2921 Telestar Court, Falls Church, VA 22042 USA. EM muk1953@aol.com NR 10 TC 0 Z9 0 U1 0 U2 0 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1708-5381 J9 VASCULAR JI Vascular PD NOV-DEC PY 2010 VL 18 IS 6 BP 367 EP 370 DI 10.2310/6670.2010.00057 PG 4 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 679AO UT WOS:000284132000010 PM 20979926 ER PT J AU Echevarria, AJ AF Echevarria, Antulio J., II TI The Echo of Battle: The Army's Way of War SO WAR IN HISTORY LA English DT Book Review C1 [Echevarria, Antulio J., II] US Army War Coll, Carlisle, PA 17013 USA. RP Echevarria, AJ (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD NOV PY 2010 VL 17 IS 4 BP 535 EP 536 DI 10.1177/0968344510377833 PG 2 WC History; International Relations SC History; International Relations GA 682KY UT WOS:000284403600010 ER PT J AU Wojciechowski, J Chase-Baldwin, K Wasieloski, LP Padilla, S Vora, GJ Taitt, CR AF Wojciechowski, Jason Chase-Baldwin, Kitty Wasieloski, Leonard P., Jr. Padilla, Susana Vora, Gary J. Taitt, Chris Rowe TI Enhancement of deoxyribonucleic acid microarray performance using post-hybridization signal amplification SO ANALYTICA CHIMICA ACTA LA English DT Article DE CombiMatrix; Microarray; Electrochemical detection; Super avidin-biotin system; Secondary enzymatic enhancement ID CATALYZED REPORTER DEPOSITION; IN-SITU HYBRIDIZATION; SUBTYPE IDENTIFICATION; EXPRESSION PROFILES; PATHOGEN DETECTION; DEHALOCOCCOIDES; PREDICTORS; CANCER; ASSAYS; GENES AB Microarray performance depends upon the ability to screen samples against a vast array of probes with the appropriate sensitivity and selectivity While these factors are significantly influenced by probe design they are also subject to the particular detection methodology and reagents employed Herein we describe the incorporation of super avidin-biotin system (SABS) and secondary enzymatic enhancement (SEE) as post-hybridization signal amplification techniques to improve the sensitivity of oligonucleotide microarrays To these ends we tested these methods on electrochemically Interrogated arrays using both purified influenza A PCR products and randomly amplified genomic Francisella tularensis DNA as targets While SABS treatment did not improve sensitivity for CombiMatrix ElectraSense (R) arrays using purified influenza A cDNA chip sensitivity was improved 10-fold for randomly amplified targets SEE improved performance to a greater degree and was able to lower the detection limits 10-fold for influenza A and 100-fold for F tularensis DNA These results indicate the promising capability of post-hybridization amplification techniques for enhancing microarray performance Published by Elsevier B V C1 [Wojciechowski, Jason; Vora, Gary J.; Taitt, Chris Rowe] USN, Ctr Biomol Sci & Engn, Res Lab, Washington, DC 20376 USA. [Chase-Baldwin, Kitty; Wasieloski, Leonard P., Jr.; Padilla, Susana] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Wojciechowski, J (reprint author), USN, Ctr Biomol Sci & Engn, Res Lab, Bld 30,4555 Overlook Ave SW, Washington, DC 20376 USA. OI Vora, Gary/0000-0002-0657-8597 FU Joint Science and Technology Office for Chemical and Biological Defense/Defense Threat Reduction Agency [8 10006_07_RD_B, 8 10016_07_NRL_B]; American Society for Engineering Education FX This work was supported by Joint Science and Technology Office for Chemical and Biological Defense/Defense Threat Reduction Agency Projects 8 10006_07_RD_B and 8 10016_07_NRL_B J W was supported by a postdoctoral fellowship sponsored through the American Society for Engineering Education Opinions interpretations conclusions and recommendations are those of the authors and do not represent those of the US Government the US Department of Defense US Army or the US Navy NR 32 TC 5 Z9 5 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD OCT 29 PY 2010 VL 679 IS 1-2 BP 85 EP 90 DI 10.1016/j.aca.2010.09.007 PG 6 WC Chemistry, Analytical SC Chemistry GA 677CA UT WOS:000283965500011 PM 20951861 ER PT J AU Li, Y Wang, N Perkins, EJ Zhang, CY Gong, P AF Li, Ying Wang, Nan Perkins, Edward J. Zhang, Chaoyang Gong, Ping TI Identification and Optimization of Classifier Genes from Multi-Class Earthworm Microarray Dataset SO PLOS ONE LA English DT Article ID SUPPORT VECTOR MACHINES; CANCER CLASSIFICATION; FEATURE-SELECTION; BINDING-PROTEIN; VARIABLE SELECTION; EISENIA-FOETIDA; EXPRESSION DATA; DISCOVERY; BIOINFORMATICS; RECOGNITION AB Monitoring, assessment and prediction of environmental risks that chemicals pose demand rapid and accurate diagnostic assays. A variety of toxicological effects have been associated with explosive compounds TNT and RDX. One important goal of microarray experiments is to discover novel biomarkers for toxicity evaluation. We have developed an earthworm microarray containing 15,208 unique oligo probes and have used it to profile gene expression in 248 earthworms exposed to TNT, RDX or neither. We assembled a new machine learning pipeline consisting of several well-established feature filtering/selection and classification techniques to analyze the 248-array dataset in order to construct classifier models that can separate earthworm samples into three groups: control, TNT-treated, and RDX-treated. First, a total of 869 genes differentially expressed in response to TNT or RDX exposure were identified using a univariate statistical algorithm of class comparison. Then, decision tree-based algorithms were applied to select a subset of 354 classifier genes, which were ranked by their overall weight of significance. A multiclass support vector machine (MC-SVM) method and an unsupervised K-mean clustering method were applied to independently refine the classifier, producing a smaller subset of 39 and 30 classifier genes, separately, with 11 common genes being potential biomarkers. The combined 58 genes were considered the refined subset and used to build MC-SVM and clustering models with classification accuracy of 83.5% and 56.9%, respectively. This study demonstrates that the machine learning approach can be used to identify and optimize a small subset of classifier/biomarker genes from high dimensional datasets and generate classification models of acceptable precision for multiple classes. C1 [Li, Ying; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Perkins, Edward J.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. [Gong, Ping] SpecPro Inc, Environm Serv, Vicksburg, MS USA. RP Li, Y (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM ping.gong@usace.army.mil FU U.S. Army Environmental Quality Technology Research; ERDC; U.S. Army Chief of Engineers FX This work was supported by the U.S. Army Environmental Quality Technology Research Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SpecPro Inc. supported Ping Gong through a contract granted by ERDC, and through this employment is considered by PLoS ONE to have played a role in the research. Permission to publish this information was granted by the U.S. Army Chief of Engineers. NR 48 TC 8 Z9 9 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 28 PY 2010 VL 5 IS 10 AR e13715 DI 10.1371/journal.pone.0013715 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 672HN UT WOS:000283573800014 PM 21060837 ER PT J AU Dupuy, LC Richards, MJ Reed, DS Schmaljohn, CS AF Dupuy, Lesley C. Richards, Michelle J. Reed, Douglas S. Schmaljohn, Connie S. TI Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates SO VACCINE LA English DT Article DE Venezuelan equine encephalitis virus; (VEEV); DNA vaccine; Nonhuman primates; Aerosol challenge ID ATTENUATED VACCINES; LIVE; STRAIN; ELECTROPORATION; IMMUNIZATION; INFECTIONS; MACAQUES; HAMSTERS; CELLS; MICE AB A study to evaluate the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus (VEEV) DNA vaccine in an aerosol model of nonhuman primate infection was performed Cynomolgus macaques vaccinated with a plasmid expressing the 26S structural genes of VEEV subtype IAB by particle-mediated epidermal delivery (PMED) developed virus-neutralizing antibodies No serum viremia was detected in two out of three macaques vaccinated with the VEEV DNA after aerosol challenge with homologous virus while one displayed a low viremia on a single day postchallenge In contrast all three macaques vaccinated with empty vector DNA developed a high viremia that persisted for at least 3 days after challenge In addition macaques vaccinated with the VEEV DNA had reduced febrile reactions lymphopenia and clinical signs of disease postchallenge as compared to negative control macaques Therefore although the sample size was small in this pilot study these results indicate that a VEEV DNA vaccine administered by PMED can at least partially protect nonhuman primates against an aerosol VEEV challenge (C) 2010 Elsevier Ltd All rights reserved C1 [Dupuy, Lesley C.; Richards, Michelle J.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Reed, Douglas S.] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Dupuy, LC (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. OI Reed, Douglas/0000-0003-0076-9023 FU Defense Threat Reduction Agency (DTRA) [H H 0001_07_RD_B] FX This research was supported by grant H H 0001_07_RD_B from the Defense Threat Reduction Agency (DTRA) The opinions interpretations conclusions and recommendations contained herein are those of the authors and are not necessarily endorsed by the U S Army NR 30 TC 12 Z9 12 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD OCT 28 PY 2010 VL 28 IS 46 BP 7345 EP 7350 DI 10.1016/j.vaccine.2010.09.005 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 683TY UT WOS:000284499300001 PM 20851089 ER PT J AU Hurst, FP Jindal, RM Graham, LJ Falta, EM Elster, EA Stackhouse, GB Agodoa, LY Lentine, KL Salifu, MO Abbott, KC AF Hurst, Frank P. Jindal, Rahul M. Graham, Lindsey J. Falta, Edward M. Elster, Eric A. Stackhouse, George B. Agodoa, Lawrence Y. Lentine, Krista L. Salifu, Moro O. Abbott, Kevin C. TI Incidence, Predictors, Costs, and Outcome of Renal Cell Carcinoma After Kidney Transplantation: USRDS Experience SO TRANSPLANTATION LA English DT Article DE Renal cell carcinoma; Kidney cysts; Cost of screening; Risk of renal cell carcinoma ID UNITED-STATES; DISEASE; RECIPIENTS; CANCER AB Introduction. We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation. Methods. This is a retrospective cohort of 40,821 Medicare primary renal transplant recipients transplanted from January 1, 2000, to July 1, 2005, and followed up till December 31, 2005, excluding those with prior RCC or nephrectomy. Kaplan-Meier analysis was performed to determine the time of occurrence of RCC, and Cox regression was used to determine factors associated with RCC. Results. Three hundred sixty-eight patients were diagnosed with RCC within 3 years after transplant (incidence of 3.16 per 1000 person years). The 3-year incidence of RCC posttransplant was 9.29 per 1000 person years (2.3%) for those with pretransplant cysts and 3.08 per 1000 person years (0.7%) without pretransplant cysts. RCC was diagnosed disproportionately early posttransplant in patients with cysts. Cysts were independently associated with increased risk of RCC, as was male gender, older recipient, donor age, African American recipient, increased time on dialysis and acute rejection within first year posttransplant. RCC was associated with increased risk of mortality with a higher risk with pretransplant cysts. Patients who developed RCC had higher cumulative median costs ($55,456 at 2 years) than those who did not develop RCC ($40,369). There was no "clustering" of RCC in individual states or centers more than would be expected by chance. Conclusion. RCC was diagnosed disproportionately early in patients with pretransplant renal cysts and was associated with a worse prognosis and increased costs. C1 [Jindal, Rahul M.] Walter Reed Army Med Ctr, Dept Organ Transplantat, Organ Transplant Serv, Washington, DC 20307 USA. [Hurst, Frank P.; Graham, Lindsey J.; Elster, Eric A.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Hurst, Frank P.; Jindal, Rahul M.; Graham, Lindsey J.; Falta, Edward M.; Elster, Eric A.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Nephrol & Surg, Bethesda, MD 20814 USA. [Jindal, Rahul M.] George Washington Univ, Dept Med, Washington, DC USA. [Stackhouse, George B.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDKD, NIH, Bethesda, MD 20892 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Ctr Outcomes Res, St Louis, MO USA. [Salifu, Moro O.] Suny Downstate Med Ctr, Dept Med, Div Nephrol, Brooklyn, NY 11203 USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Dept Organ Transplantat, Organ Transplant Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 16 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD OCT 27 PY 2010 VL 90 IS 8 BP 898 EP 904 DI 10.1097/TP.0b013e3181f30479 PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 668JD UT WOS:000283263700015 PM 21248500 ER PT J AU DiFurio, M Sundborg, M AF DiFurio, Megan Sundborg, Michael TI Unsatisfactory Pap Tests: A Performance Improvement Project SO CANCER CYTOPATHOLOGY LA English DT Meeting Abstract C1 [DiFurio, Megan] Womack Army Med Ctr, Dept Pathol, Ft Bragg, NC USA. [Sundborg, Michael] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1934-662X J9 CANCER CYTOPATHOL JI Cancer Cytopathol. PD OCT 25 PY 2010 VL 118 IS 5 SU S BP 388 EP 389 PG 2 WC Oncology; Pathology SC Oncology; Pathology GA 671DO UT WOS:000283480700118 ER PT J AU Huang, LH Liu, Q Chen, RR Chu, D Hsu, AT AF Huang, Lihong Liu, Qi Chen, Rongrong Chu, Deryn Hsu, Andrew T. TI Layered double hydroxide derived Co-0.3 Mg2.7Al1-xFexO4.5 +/-delta catalysts for hydrogen production via auto-thermal reforming of bio-ethanol SO CATALYSIS COMMUNICATIONS LA English DT Article DE Hydrogen production; Auto-thermal reforming of ethanol; Layered double hydroxide; Hydrotalcite; Co catalyst ID NICKEL-BASED CATALYSTS; HYDROTALCITE PRECURSORS; FUEL-CELLS; METHANE; OXIDES; IRON; OXIDATION; GAS; XPS AB Layered double hydroxide-derived Co-0.3 Mg(2.7A)l(1-x)Fe(x)O(4.5 +/-delta) catalysts were prepared via co-precipitation and tested in auto-thermal reforming of ethanol for hydrogen production. The layered double hydroxide precursors show typical hydrotalcite-like structures and form a similar MgO cubic structure after calcination. Compared with iron-free catalyst, the Co-0.3 Mg2.7Al0.9Fe0.1O4.5 +/-delta performs better in auto-thermal reforming of ethanol: the conversion of ethanol remains near 100%, and the H-2 yield stays above 3.2 mol H-2/mol EtOH throughout the 30-h test. The improved performance can be attributed to the stable Cobalt species within Mg(Al)O matrix, the higher surface area, and the synergic effects of Co and Fe. (C) 2010 Elsevier B.V. All rights reserved. C1 [Hsu, Andrew T.] Wright State Univ, Dayton, OH 45435 USA. [Huang, Lihong; Liu, Qi; Chen, Rongrong] Indiana Univ Purdue Univ, Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Hsu, AT (reprint author), Wright State Univ, 3640 Colonel Glenn Hwy, Dayton, OH 45435 USA. EM andrew.hsu@wright.edu FU U.S. Army Research Lab [W911NF-07-2-0036] FX This work is partially supported by the U.S. Army Research Lab (Grant No. W911NF-07-2-0036). The authors wish to thank Ms. Rosalice Buehrer of Department of Earth Sciences at IUPUI for ICP-OES tests. NR 22 TC 13 Z9 14 U1 3 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-7367 J9 CATAL COMMUN JI Catal. Commun. PD OCT 25 PY 2010 VL 12 IS 1 BP 40 EP 45 DI 10.1016/j.catcom.2010.05.019 PG 6 WC Chemistry, Physical SC Chemistry GA 670SJ UT WOS:000283447300009 ER PT J AU Berg, MJ Hill, SC Pan, YL Videen, G AF Berg, Matthew J. Hill, Steven C. Pan, Yong-Le Videen, Gorden TI Two-dimensional Guinier analysis: Application to single aerosol particles in-flight SO OPTICS EXPRESS LA English DT Article ID SMALL-ANGLE SCATTERING AB This work presents an apparatus that measures near-forward two-dimensional elastic scattering patterns of single aerosol particles and proposes a two-angle extension of the Guinier law to analyze these patterns. The particles, which approximately range from 2 to 8 micrometers in size, flow through the apparatus in an aerosol stream. A spatial filtering technique separates the near-forward portion of the patterns from the illumination light. Contours intended to represent the geometrical profile of the particles are generated from the patterns using the extension of the Guinier law. The analysis is applied to spherical and nonspherical particles, and the resulting contours are found to be consistent with particle shape only for spherical particles. (C) 2010 Optical Society of America C1 [Berg, Matthew J.] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Berg, Matthew J.; Hill, Steven C.; Pan, Yong-Le; Videen, Gorden] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. RP Berg, MJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. EM matt.berg@msstate.edu FU United States Defense Threat Reduction Agency FX The authors are thankful for assistance provided by James Sumner for the SEM images, advice provided by Dave Ligon, and helpful discussions with Chris Sorensen. This work was funded by the United States Defense Threat Reduction Agency. NR 11 TC 7 Z9 7 U1 3 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 25 PY 2010 VL 18 IS 22 BP 23343 EP 23352 DI 10.1364/OE.18.023343 PG 10 WC Optics SC Optics GA 672CK UT WOS:000283560400075 PM 21164675 ER PT J AU Pixton, BM Greivenkamp, JE AF Pixton, Bruce M. Greivenkamp, John E. TI Spherical aberration gauge for human vision SO APPLIED OPTICS LA English DT Article ID ADAPTIVE OPTICS SIMULATION; SPATIAL LIGHT-MODULATOR; SOFT CONTACT-LENSES; HUMAN EYE; INTRAOCULAR LENSES; COMPENSATION; PERFORMANCE; GENERATORS; ACCOMMODATION; DESIGN AB Spherical aberration affects vision in varying degrees depending on pupil size, accommodation, individual eye characteristics, and interpretations by the brain. We developed a spherical aberration gauge to help evaluate the correction potential of spherical aberration in human vision. Variable aberration levels are achieved with laterally shifted polynomial plates from which a user selects a setting that provides the best vision. The aberration is mapped into the pupil of the eye using a simple telescope. Calibration data are given. (C) 2010 Optical Society of America C1 [Pixton, Bruce M.; Greivenkamp, John E.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. RP Pixton, BM (reprint author), USA, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Washington, DC USA. EM pixtonb@optics.arizona.edu NR 32 TC 2 Z9 3 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2010 VL 49 IS 30 BP 5906 EP 5913 DI 10.1364/AO.49.005906 PG 8 WC Optics SC Optics GA 668DC UT WOS:000283247800027 PM 20962957 ER PT J AU Jackson, JL Shimeall, W Sessums, L DeZee, KJ Becher, D Diemer, M Berbano, E O'Malley, PG AF Jackson, Jeffrey L. Shimeall, William Sessums, Laura DeZee, Kent J. Becher, Dorothy Diemer, Margretta Berbano, Elizabeth O'Malley, Patrick G. TI Tricyclic antidepressants and headaches: systematic review and meta-analysis SO BRITISH MEDICAL JOURNAL LA English DT Review ID TENSION-TYPE HEADACHE; RANDOMIZED CONTROLLED-TRIAL; CONTROLLED CLINICAL-TRIAL; DOUBLE-BLIND; PROPHYLACTIC TREATMENT; MIGRAINE PROPHYLAXIS; SPINAL MANIPULATION; PUBLICATION BIAS; MIXED HEADACHE; AMITRIPTYLINE AB Objective To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. Design Meta-analysis. Data sources Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks. Data extraction Frequency of headaches (number of headache attacks for migraine and number of days with headache for tension-type headaches), intensity of headache, and headache index. Results 37 studies met the inclusion criteria. Tricyclics significantly reduced the number of days with tension-type headache and number of headache attacks from migraine than placebo (average standardised mean difference -1.29, 95% confidence interval -2.18 to -0.39 and -0.70, -0.93 to -0.48) but not compared with selective serotonin reuptake inhibitors (-0.80, -2.63 to 0.02 and -0.20, -0.60 to 0.19). The effect of tricyclics increased with longer duration of treatment (beta=-0.11, 95% confidence interval -0.63 to -0.15; P<0.0005). Tricyclics were also more likely to reduce the intensity of headaches by at least 50% than either placebo (tension-type: relative risk 1.41, 95% confidence interval 1.02 to 1.89; migraine: 1.80, 1.24 to 2.62) or selective serotonin reuptake inhibitors (1.73, 1.34 to 2.22 and 1.72, 1.15 to 2.55). Tricyclics were more likely to cause adverse effects than placebo (1.53, 95% confidence interval 1.11 to 2.12) and selective serotonin reuptake inhibitors (2.22, 1.52 to 3.32), including dry mouth (P<0.0005 for both), drowsiness (P<0.0005 for both), and weight gain (P<0.001 for both), but did not increase dropout rates (placebo: 1.22, 0.83 to 1.80, selective serotonin reuptake inhibitors: 1.16, 0.81 to 2.97). Conclusions Tricyclic antidepressants are effective in preventing migraine and tension-type headaches and are more effective than selective serotonin reuptake inhibitors, although with greater adverse effects. The effectiveness of tricyclics seems to increase over time. C1 [Jackson, Jeffrey L.] Zablocki VA, Div Gen Med, Milwaukee, WI 53295 USA. [Sessums, Laura; Becher, Dorothy; Diemer, Margretta; Berbano, Elizabeth] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Shimeall, William] Natl Naval Med Ctr, Bethesda, MD USA. [DeZee, Kent J.; O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Jackson, JL (reprint author), Zablocki VA, Div Gen Med, 5000 Natl Ave, Milwaukee, WI 53295 USA. EM Jeffrey.jackson6@va.gov NR 68 TC 58 Z9 58 U1 2 U2 7 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BRIT MED J JI Br. Med. J. PD OCT 20 PY 2010 VL 341 AR c5222 DI 10.1136/bmj.c5222 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA 671ZL UT WOS:000283552700001 PM 20961988 ER PT J AU Everley, PA Dillman, JF AF Everley, Patrick A. Dillman, James F., III TI Genomics and proteomics in chemical warfare agent research: Recent studies and future applications SO TOXICOLOGY LETTERS LA English DT Review DE Chemical warfare agent; Sarin; Soman; Sulfur mustard; Genomics; Proteomics ID HUMAN EPIDERMAL-KERATINOCYTES; SPECTROMETRY-BASED PROTEOMICS; BRONCHOALVEOLAR LAVAGE FLUID; GENE-EXPRESSION PROFILES; CENTRAL-NERVOUS-SYSTEM; SULFUR MUSTARD; MESSENGER-RNA; RAT-BRAIN; BIS-(2-CHLOROETHYL) SULFIDE; MICROARRAY ANALYSIS AB Medical research on the effects of chemical warfare agents (CWAs) has been ongoing for nearly 100 years, yet these agents continue to pose a serious threat to deployed military forces and civilian populations. CWAs are extremely toxic, relatively inexpensive, and easy to produce, making them a legitimate weapon of choice for terrorist organizations. While the mechanisms of action for many CWAs have been known for years. questions about their molecular effects following acute and chronic exposure remain largely unanswered. Global approaches that can pinpoint which cellular pathways are altered in response to CWAs and characterize long-term toxicity have not been widely used. Fortunately, innovations in genomics and proteomics technologies now allow for thousands of genes and proteins to be identified and subsequently quantified in a single experiment. Advanced bioinformatics software can also help decipher large-scale changes observed, leading to mapping of signaling pathways, functional characterization, and identification of potential therapeutic targets. Here we present an overview of how genomics and proteomics technologies have been applied to CWA researh and also provide a series of questions focused on how these techniques could further our understanding of CWA toxicity. Published by Elsevier Ireland Ltd. C1 [Everley, Patrick A.; Dillman, James F., III] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Everley, PA (reprint author), USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM patrick.everley@us.army.mil; james.dillman@us.army.mil FU U.S. Army; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division FX lWe thank D.M. Cerasoli, J.S. Graham, E.A. Johnson, R.K. Kan, P.M. McNutt, G.A. Rockwood, T.M. Shih, W.J. Smith, and T.R. Varney (USAMRICD, Aberdeen Proving Ground, MD, USA) for helpful discussions and critical reading of the manuscript. Financial support was provided by In-house Laboratory Independent Research funding from the U.S. Army (P.A.E) and by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (J.F.D.). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 56 TC 2 Z9 2 U1 1 U2 24 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 20 PY 2010 VL 198 IS 3 BP 297 EP 303 DI 10.1016/j.toxlet.2010.08.003 PG 7 WC Toxicology SC Toxicology GA 663AL UT WOS:000282855300001 PM 20708669 ER PT J AU Branco, LM Grove, JN Geske, FJ Boisen, ML Muncy, IJ Magliato, SA Henderson, LA Schoepp, RJ Cashman, KA Hensley, LE Garry, RF AF Branco, Luis M. Grove, Jessica N. Geske, Frederick J. Boisen, Matt L. Muncy, Ivana J. Magliato, Susan A. Henderson, Lee A. Schoepp, Randal J. Cashman, Kathleen A. Hensley, Lisa E. Garry, Robert F. TI Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever SO VIROLOGY JOURNAL LA English DT Article ID PROTECTS GUINEA-PIGS; HUMAN-PAPILLOMAVIRUS; GLYCOPROTEIN GENE; INFLUENZA-VIRUS; CELLS; ANTIBODIES; INFECTION; SAFETY; EBOLA; EPIDEMIOLOGY AB Background: Lassa fever is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic. Treatment of acute Lassa fever infections has successfully utilized intravenous administration of ribavirin, a nucleotide analogue drug, but this is not an approved use; efficacy of oral administration has not been demonstrated. To date, several potential new vaccine platforms have been explored, but none have progressed toward clinical trials and commercialization. Therefore, the development of a robust vaccine platform that could be generated in sufficient quantities and at a low cost per dose could herald a subcontinent-wide vaccination program. This would move Lassa endemic areas toward the control and reduction of major outbreaks and endemic infections. To this end, we have employed efficient mammalian expression systems to generate a Lassa virus (LASV)-like particle (VLP)-based modular vaccine platform. Results: A mammalian expression system that generated large quantities of LASV VLP in human cells at small scale settings was developed. These VLP contained the major immunological determinants of the virus: glycoprotein complex, nucleoprotein, and Z matrix protein, with known post-translational modifications. The viral proteins packaged into LASV VLP were characterized, including glycosylation profiles of glycoprotein subunits GP1 and GP2, and structural compartmentalization of each polypeptide. The host cell protein component of LASV VLP was also partially analyzed, namely glycoprotein incorporation, though the identity of these proteins remain unknown. All combinations of LASV Z, GPC, and NP proteins that generated VLP did not incorporate host cell ribosomes, a known component of native arenaviral particles, despite detection of small RNA species packaged into pseudoparticles. Although VLP did not contain the same host cell components as the native virion, electron microscopy analysis demonstrated that LASV VLP appeared structurally similar to native virions, with pleiomorphic distribution in size and shape. LASV VLP that displayed GPC or GPC+NP were immunogenic in mice, and generated a significant IgG response to individual viral proteins over the course of three immunizations, in the absence of adjuvants. Furthermore, sera from convalescent Lassa fever patients recognized VLP in ELISA format, thus affirming the presence of native epitopes displayed by the recombinant pseudoparticles. Conclusions: These results established that modular LASV VLP can be generated displaying high levels of immunogenic viral proteins, and that small laboratory scale mammalian expression systems are capable of producing multi-milligram quantities of pseudoparticles. These VLP are structurally and morphologically similar to native LASV virions, but lack replicative functions, and thus can be safely generated in low biosafety level settings. LASV VLP were immunogenic in mice in the absence of adjuvants, with mature IgG responses developing within a few weeks after the first immunization. These studies highlight the relevance of a VLP platform for designing an optimal vaccine candidate against Lassa hemorrhagic fever, and warrant further investigation in lethal challenge animal models to establish their protective potential. C1 [Branco, Luis M.; Grove, Jessica N.; Garry, Robert F.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. [Branco, Luis M.] Autoimmune Technol LLC, New Orleans, LA USA. [Geske, Frederick J.; Boisen, Matt L.; Muncy, Ivana J.] Corgenix Med Corp, Broomfield, CO USA. [Magliato, Susan A.] Tulane Univ, Dept Pathol, New Orleans, LA 70118 USA. [Henderson, Lee A.] Vybion Inc, Ithaca, NY USA. [Schoepp, Randal J.] USA, Med Res Inst Infect Dis, Appl Diagnost Branch, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Cashman, Kathleen A.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Viral Therapeut Branch, Diagnost Syst Div,Virol Div, Ft Detrick, MD 21702 USA. RP Garry, RF (reprint author), Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. EM rfgarry@tulane.edu FU Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases [AI067188, AI082119]; Louisiana Board of Regents [RC-0013-07]; Division of GEIS Operations at the Armed Forces Health Surveillance Center [C0169_10_RD] FX This work was supported by Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases Challenge and Partnership Grant Numbers AI067188 and AI082119, and RC-0013-07 from the Louisiana Board of Regents. The research described herein was sponsored in part by the Division of GEIS Operations at the Armed Forces Health Surveillance Center, Research Plan C0169_10_RD. We thank the members of the Hemorrhagic Fever Diagnostic Consortium, and Lassa Fever - Mano River Union for ongoing support. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 62 TC 25 Z9 27 U1 1 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD OCT 20 PY 2010 VL 7 AR 279 DI 10.1186/1743-422X-7-279 PG 19 WC Virology SC Virology GA 678VH UT WOS:000284109700001 PM 20961433 ER PT J AU Kelton, ML LeardMann, CA Smith, B Boyko, EJ Hooper, TI Gackstetter, GD Bliese, PD Hoge, CW Smith, TC AF Kelton, Molly L. LeardMann, Cynthia A. Smith, Besa Boyko, Edward J. Hooper, Tomoko I. Gackstetter, Gary D. Bliese, Paul D. Hoge, Charles W. Smith, Tyler C. CA Millennium Cohort Study Team TI Exploratory factor analysis of self-reported symptoms in a large, population-based military cohort SO BMC MEDICAL RESEARCH METHODOLOGY LA English DT Article ID GULF-WAR SYNDROME; POSTTRAUMATIC-STRESS-DISORDER; MILLENNIUM COHORT; US MILITARY; CORRELATION-COEFFICIENT; COMBAT DEPLOYMENT; HEALTH; PREVALENCE; VALIDATION; EXPOSURES AB Background: US military engagements have consistently raised concern over the array of health outcomes experienced by service members postdeployment. Exploratory factor analysis has been used in studies of 1991 Gulf War-related illnesses, and may increase understanding of symptoms and health outcomes associated with current military conflicts in Iraq and Afghanistan. The objective of this study was to use exploratory factor analysis to describe the correlations among numerous physical and psychological symptoms in terms of a smaller number of unobserved variables or factors. Methods: The Millennium Cohort Study collects extensive self-reported health data from a large, population-based military cohort, providing a unique opportunity to investigate the interrelationships of numerous physical and psychological symptoms among US military personnel. This study used data from the Millennium Cohort Study, a large, population-based military cohort. Exploratory factor analysis was used to examine the covariance structure of symptoms reported by approximately 50,000 cohort members during 2004-2006. Analyses incorporated 89 symptoms, including responses to several validated instruments embedded in the questionnaire. Techniques accommodated the categorical and sometimes incomplete nature of the survey data. Results: A 14-factor model accounted for 60 percent of the total variance in symptoms data and included factors related to several physical, psychological, and behavioral constructs. A notable finding was that many factors appeared to load in accordance with symptom co-location within the survey instrument, highlighting the difficulty in disassociating the effects of question content, location, and response format on factor structure. Conclusions: This study demonstrates the potential strengths and weaknesses of exploratory factor analysis to heighten understanding of the complex associations among symptoms. Further research is needed to investigate the relationship between factor analytic results and survey structure, as well as to assess the relationship between factor scores and key exposure variables. C1 [Kelton, Molly L.; LeardMann, Cynthia A.; Smith, Besa; Smith, Tyler C.] US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, San Diego, CA USA. [Boyko, Edward J.] Puget Sound Hlth Care Syst, Vet Affairs, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Bliese, Paul D.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. RP LeardMann, CA (reprint author), US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, San Diego, CA USA. EM cynthia.leardmann@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland; VA Puget Sound Health Care System; US Department of Defense [60002]; US Army Medical Research and Materiel Command, Fort Detrick, Maryland FX We are indebted to the Millennium Cohort Study participants, without whom these analyses would not be possible. We thank Scott L. Seggerman from the Management Information Division, US Defense Manpower Data Center, Seaside, California. Additionally, we thank Michelle Stoia from the Naval Health Research Center. We also thank all the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. VA Puget Sound Health Care System provided support for Dr. Boyko's involvement in this research. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.; This report represents Naval Health Research Center report 09-21, supported by the US Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Department of the Navy, US Department of the Army, US Department of the Air Force, US Department of Defense, US Department of Veterans Affairs, or the US Government. This work was supported by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The funding organization had no role in the design and conduct of the study; collection, preparation, analysis, or interpretation of data; or preparation, review, or approval of the manuscript. NR 41 TC 4 Z9 4 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2288 J9 BMC MED RES METHODOL JI BMC Med. Res. Methodol. PD OCT 15 PY 2010 VL 10 AR 94 DI 10.1186/1471-2288-10-94 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 673MQ UT WOS:000283668000001 PM 20950474 ER PT J AU Baker, EL Capellos, C Stiel, LI Pincay, J AF Baker, Ernest L. Capellos, Christos Stiel, Leonard I. Pincay, Jack TI Accuracy and Calibration of High Explosive Thermodynamic Equations of State SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE detonation; detonation products; detonation velocity; equation of state AB The Jones-Wilkins-Lee-Baker (JWLB) equation of state (EOS) was developed to more accurately describe overdriven detonation while maintaining an accurate description of high explosive products expansion work output. The increased mathematical complexity of the JWLB high explosive equations of state provides increased accuracy for practical problems of interest. Increased numbers of parameters are often justified based on improved physics descriptions but can also mean increased calibration complexity. A generalized extent of aluminum reaction Jones-Wilkins-Lee (JWL)-based EOS was developed in order to more accurately describe the observed behavior of aluminized explosives detonation products expansion. A calibration method was developed to describe the unreacted, partially reacted, and completely reacted explosive using nonlinear optimization. A reasonable calibration of a generalized extent of aluminum reaction JWLB EOS as a function of aluminum reaction fraction has not yet been achieved due to the increased mathematical complexity of the JWLB form. C1 [Baker, Ernest L.; Capellos, Christos; Pincay, Jack] US ARMY ARDEC, AETC, Picatinny Arsenal, NJ 07806 USA. [Stiel, Leonard I.] NYU, Polytech Inst, Metrotech Ctr 6, Brooklyn, NY USA. RP Baker, EL (reprint author), US ARMY ARDEC, B3022, Picatinny Arsenal, NJ 07806 USA. EM ernest.l.baker@us.army.mil NR 15 TC 1 Z9 1 U1 6 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0737-0652 EI 1545-8822 J9 J ENERG MATER JI J. Energ. Mater. PD OCT 15 PY 2010 VL 28 SU 1 SI SI BP 140 EP 153 DI 10.1080/07370652.2010.505597 PG 14 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA V31UX UT WOS:000208909600009 ER PT J AU Donald, JGA Kovanen, A Danon, Y AF Gillich, Donald J. Kovanen, Andrew Danon, Yaron TI Deuterated target comparison for pyroelectric crystal D-D nuclear fusion experiments SO JOURNAL OF NUCLEAR MATERIALS LA English DT Article ID GENERATION; SYSTEM AB Different target materials were investigated to determine which ones are favorable to increasing the theoretical neutron yield using pyroelectric crystal D-D nuclear fusion. Calculations show that deuterated polyethylene (CD(2)) will potentially yield the highest number of neutrons compared to the other targets investigated. However, deuterated plastic targets have been found to erode over the course of experiments. Published by Elsevier B.V. C1 [Danon, Yaron] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. [Gillich, Donald J.; Kovanen, Andrew] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Danon, Y (reprint author), Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. EM danony@rpi.edu NR 21 TC 6 Z9 6 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3115 J9 J NUCL MATER JI J. Nucl. Mater. PD OCT 15 PY 2010 VL 405 IS 2 BP 181 EP 185 DI 10.1016/j.jnucmat.2010.08.012 PG 5 WC Materials Science, Multidisciplinary; Nuclear Science & Technology SC Materials Science; Nuclear Science & Technology GA 670GX UT WOS:000283410300015 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Korean War: A History SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 89 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000168 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Into the Crater: The Mine Attack at Petersburg SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000165 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Border War: Fighting Over Slavery Before the Civil War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000164 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Three Armies on the Somme: The First Battle of the Twentieth Century SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000167 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Stealing Secrets: How a Few Daring Women Deceived Generals, Impacted Battles, and Altered the Course of the Civil War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000166 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI After the War: The Lives and Images of Major Civil War Figures After the Shooting Stopped SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000163 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Day Dixie Died: The Battle of Atlanta SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000162 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Engines of War: How Wars Were Won and Lost on the Railways SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000175 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI How We Fight: Crusades, Quagmires, and the American Way of War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000174 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Operation Dark Heart: Spycraft and Special Ops on the Frontlines of Afghanistan-and the Path to Victory SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000170 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI How Wars End: Why We Always Fight the Last Battle SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000173 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Into the Viper's Nest: The First Pivotal Battle of the Afghan War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000169 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Peace Meals: A War Reporter's Journey, with Friends, Feasts, and Candy-Wrapped Kalashnikovs SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000171 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Gun SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2010 VL 135 IS 17 BP 89 EP 89 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 670WC UT WOS:000283457000172 ER PT J AU Modi, SH Dikovics, KB Gevgilili, H Mago, G Bartolucci, SF Fisher, FT Kalyon, DM AF Modi, Shriraj H. Dikovics, Kimberly B. Gevgilili, Halil Mago, Gaurav Bartolucci, Stephen F. Fisher, Frank T. Kalyon, Dilhan M. TI Nanocomposites of poly(ether ether ketone) with carbon nanofibers: Effects of dispersion and thermo-oxidative degradation on development of linear viscoelasticity and crystallinity SO POLYMER LA English DT Article DE PEEK; Nanocomposites; Carbon nanofibers ID NANOTUBE/POLYMER COMPOSITES; THERMOPLASTIC COMPOSITES; INDUCED CRYSTALLIZATION; MECHANICAL-PROPERTIES; THERMAL-DEGRADATION; POLYMER MATRIX; CURE BEHAVIOR; EPOXY-RESIN; NANOTUBES; PEEK AB Poly(ether ether ketone), PEEK, is a widely used engineering plastic that is especially suitable for high temperature applications. Compounding of PEEK with carbon nanofibers, CNF, has the potential of enhancing its mechanical and thermal properties further, even at relatively low CNF concentrations. However, such enhancements can be compromised by myriad factors, some of which are elucidated in this study. Considering that the dispersion of the CNF into any high molecular weight polymer is a challenge, two different processing methods, i.e., melt and solution processing were used to prepare PEEK nanocomposites with low aspect ratio carbon nanofibers. The linear viscoelastic material functions of PEEK nanocomposites in the solid and molten states were characterized as indirect indicators of the dispersion state of the nanofibers and suggested that the dispersion of nanofibers into PEEK becomes difficult at increasing CNF concentrations for both solution and melt processing methods. Furthermore, the time-dependence of the linear viscoelastic material functions of the PEEK/CNF nanocomposites at 360-400 degrees C indicated that PEEK undergoes thermo-oxidative cross-linking under typical melt processing conditions, thus preventing better dispersion by progressive increases of the mixing time and specific energy input during melt processing. The crystallization behavior of PEEK is also affected by the presence of CNF and degree of cross-linking, with the rate of crystallization decreasing with increasing degree of cross-linking and upon the incorporation of CNFs both for the solution and melt processed PEEK nanocomposites. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Modi, Shriraj H.; Dikovics, Kimberly B.; Gevgilili, Halil; Kalyon, Dilhan M.] Stevens Inst Technol, Highly Filled Mat Inst, Hoboken, NJ 07030 USA. [Modi, Shriraj H.; Dikovics, Kimberly B.; Kalyon, Dilhan M.] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Mago, Gaurav; Fisher, Frank T.] Stevens Inst Technol, Dept Mech Engn, Hoboken, NJ 07030 USA. [Bartolucci, Stephen F.] USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. RP Kalyon, DM (reprint author), Stevens Inst Technol, Highly Filled Mat Inst, Hoboken, NJ 07030 USA. EM dilhan.kalyon@stevens.edu RI mago, gaurav/A-6753-2013; Mago, Gaurav/I-3356-2013 OI mago, gaurav/0000-0003-2316-8458; FU Benet Laboratories/ARDEC FX The investigation was funded by Benet Laboratories/ARDEC for which we are grateful. We thank Ms. Asli Ergun, Ms. Seda Vural and Mr. Daniel Ward for their help with some of the experiments. NR 52 TC 12 Z9 14 U1 2 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD OCT 15 PY 2010 VL 51 IS 22 BP 5236 EP 5244 DI 10.1016/j.polymer.2010.08.060 PG 9 WC Polymer Science SC Polymer Science GA 671DA UT WOS:000283479000029 ER PT J AU Malaviya, R Sunil, VR Cervelli, J Anderson, DR Holmes, WW Conti, ML Gordon, RE Laskin, JD Laskin, DL AF Malaviya, Rama Sunil, Vasanthi R. Cervelli, Jessica Anderson, Dana R. Holmes, Wesley W. Conti, Michele L. Gordon, Ronald E. Laskin, Jeffrey D. Laskin, Debra L. TI Inflammatory effects of inhaled sulfur mustard in rat lung SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Vesicant; Sulfur mustard; Inflammation; Lung; Apoptosis; Autophagy ID 2-CHLOROETHYL ETHYL SULFIDE; AIRWAY EPITHELIAL-CELLS; HUMAN EPIDERMAL-KERATINOCYTES; NITRIC-OXIDE SYNTHASE; EAR VESICANT MODEL; GUINEA-PIGS; OXIDATIVE STRESS; INJURY; EXPOSURE; TOXICITY AB Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian populations. The mechanisms mediating its cytotoxic effects are unknown and were investigated in the present studies. Male rats Crl:CD(SD) were anesthetized, and then intratracheally intubated and exposed to 0.7-1.4 mg/kg SM by vapor inhalation. Animals were euthanized 6, 24, 48 h or 7 days post-exposure and bronchoalveolar lavage fluid (BAL) and lung tissue collected. Exposure of rats to SM resulted in rapid pulmonary toxicity, including focal ulceration and detachment of the trachea and bronchial epithelia from underlying mucosa, thickening of alveolar septal walls and increased numbers of inflammatory cells in the tissue. There was also evidence of autophagy and apoptosis in the tissue. This was correlated with increased BAL protein content, a marker of injury to the alveolar epithelial lining. SM exposure also resulted in increased expression of markers of inflammation including cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF alpha), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-9 (MMP-9), each of which has been implicated in pulmonary toxicity. Whereas COX-2, TNF alpha and iNOS were mainly localized in alveolar regions, MMP-9 was prominent in bronchial epithelium. In contrast, expression of the anti-oxidant hemeoxygenase, and the anti-inflammatory collectin, surfactant protein-D, decreased in the lung after SM exposure. These data demonstrate that SM-induced oxidative stress and injury are associated with the generation of cytotoxic inflammatory proteins which may contribute to the pathogenic response to this vesicant. (C) 2010 Published by Elsevier Inc. C1 [Laskin, Debra L.] Rutgers State Univ, Dept Pharmacol & Toxicol, Ernest Mario Sch Pharm, Piscataway, NJ 08854 USA. [Anderson, Dana R.; Holmes, Wesley W.; Conti, Michele L.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen, MD 21010 USA. [Gordon, Ronald E.] Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA. [Laskin, Jeffrey D.] UMDNJ Robert Wood Johnson Med Sch, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA. RP Laskin, DL (reprint author), Rutgers State Univ, Dept Pharmacol & Toxicol, Ernest Mario Sch Pharm, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA. EM laskin@eohsi.rutgers.edu FU NIH [HL096426, AR055073, GM034310, ES004738, CA132624, ES005022]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S T Division FX This work was supported by NIH Grants HL096426, AR055073, GM034310, ES004738, CA132624, and ES005022, and by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S & T Division. NR 67 TC 49 Z9 53 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 15 PY 2010 VL 248 IS 2 BP 89 EP 99 DI 10.1016/j.taap.2010.07.018 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 663BG UT WOS:000282857400002 PM 20659490 ER PT J AU Penzias, AA AF Penzias, Arno Allan TI A runaway success SO NATURE LA English DT Editorial Material C1 [Penzias, Arno Allan] USA, Washington, DC USA. [Penzias, Arno Allan] Columbia Univ, New York, NY 10027 USA. [Penzias, Arno Allan] Bell Labs, Murray Hill, NJ 07974 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD OCT 14 PY 2010 VL 467 IS 7317 BP S4 EP S4 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 663PB UT WOS:000282898700003 PM 20944619 ER PT J AU Xiao, XD Zhu, ZY Dankmeyer, JL Wormald, MM Fast, RL Worsham, PL Cote, CK Amemiya, K Dimitrov, DS AF Xiao, Xiaodong Zhu, Zhongyu Dankmeyer, Jennifer L. Wormald, Michael M. Fast, Randy L. Worsham, Patricia L. Cote, Christopher K. Amemiya, Kei Dimitrov, Dimiter S. TI Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model SO PLOS ONE LA English DT Article ID V-ANTIGEN; PNEUMONIC PLAGUE; PASTEURELLA-PESTIS; FUSION PROTEIN; VIRULENCE; VACCINE; F1; PHAGOCYTOSIS; PLASMID; LCRV AB Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people throughout the recorded history of mankind. Antibiotics may provide little immediate relief to patients who have a high bacteremia or to patients infected with an antibiotic resistant strain of plague. Two virulent factors of Y. pestis are the capsid F1 protein and the low-calcium response (Lcr) V-protein or V-antigen that have been proven to be the targets for both active and passive immunization. There are mouse monoclonal antibodies (mAbs) against the F1- and V-antigens that can passively protect mice in a murine model of plague; however, there are no anti-Yersinia pestis monoclonal antibodies available for prophylactic or therapeutic treatment in humans. We identified one anti-F1-specific human mAb (m252) and two anti-V-specific human mAb (m253, m254) by panning a naive phage-displayed Fab library against the F1- and V-antigens. The Fabs were converted to IgG1s and their binding and protective activities were evaluated. M252 bound weakly to peptides located at the F1 N-terminus where a protective mouse anti-F1 mAb also binds. M253 bound strongly to a V-antigen peptide indicating a linear epitope; m254 did not bind to any peptide from a panel of 53 peptides suggesting that its epitope may be conformational. M252 showed better protection than m253 and m254 against a Y, pestis challenge in a plague mouse model. A synergistic effect was observed when the three antibodies were combined. Incomplete to complete protection was achieved when m252 was given at different times post-challenge. These antibodies can be further studied to determine their potential as therapeutics or prophylactics in Y. pestis infection in humans. C1 [Xiao, Xiaodong; Zhu, Zhongyu; Dimitrov, Dimiter S.] NCI, Prot Interact Grp, Ctr Canc Res Nanobiol Program, NIH, Frederick, MD 21701 USA. [Zhu, Zhongyu] NCI, BSP, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21701 USA. [Dankmeyer, Jennifer L.; Wormald, Michael M.; Fast, Randy L.; Worsham, Patricia L.; Cote, Christopher K.; Amemiya, Kei] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. RP Xiao, XD (reprint author), Medimmune LLC, Gaithersburg, MD USA. EM kei.amemiya@us.army.mil; dimiter.dimitrov@nih.gov FU National Institutes of Health (NIH), National Cancer Institute, Center for Cancer Research; National Cancer Institute, NIH [N01-CO-12400]; National Institute of Allergy and Infectious Diseases; Joint Science and Technology Office Defense Threat Reduction Agency (JUSTO/DTRA) [1.1A0018_07_RD_B]; SAIC-Frederick, Inc.; U.S. Government FX This project was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute, Center for Cancer Research, by federal funds from the National Cancer Institute, NIH, under contract N01-CO-12400, by the National Institute of Allergy and Infectious Diseases Biodefense Program to Dimiter S. Dimitrov and agency Joint Science and Technology Office Defense Threat Reduction Agency (JUSTO/DTRA) proposal no. 1.1A0018_07_RD_B to Kei Amemiya. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SAIC-Frederick, Inc., as one of the funders of this study, had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; SAIC-Fredereick, Inc. is a wholly owned subsidiary of Science Applications International Corporation and operates exclusively under a single, long-term contract to the National Cancer Institute, part of the U.S. National Institutes of Health. All funding is derived from the U.S. Government. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. NR 37 TC 10 Z9 12 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 13 PY 2010 VL 5 IS 10 AR e13047 DI 10.1371/journal.pone.0013047 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 663FZ UT WOS:000282869800002 PM 20976274 ER PT J AU Hoey, ML Carlson, JB Osgood, RM Kimball, B Buchwald, W AF Hoey, Megan L. Carlson, J. B. Osgood, R. M., III Kimball, B. Buchwald, W. TI rf plasma oxidation of Ni thin films sputter deposited to generate thin nickel oxide layers SO APPLIED PHYSICS LETTERS LA English DT Article ID LASER; DETECTORS; DIODES AB Nickel oxide (NiO) layers were formed on silicon (Si) substrates by plasma oxidation of nickel (Ni) film lines. This ultrathin NiO layer acted as a barrier layer to conduction, and was an integral part of a metal-insulator-metal (MIM) diode, completed by depositing gold (Au) on top of the oxide. The electrical and structural properties of the NiO thin film were examined using resistivity calculations, current-voltage (I-V) measurements and cross-sectional transmission electron microscopy (XTEM) imaging. The flow rate of the oxygen gas, chamber pressure, power, and exposure time and their influence on the characteristics of the NiO thin film were studied. [doi: 10.1063/1.3499661] C1 [Hoey, Megan L.; Carlson, J. B.; Osgood, R. M., III; Kimball, B.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Buchwald, W.] USAF, Sensors Directorate, RYHC, Res Lab,Optoelect Technol Branch, Hanscom AFB, MA 01731 USA. RP Hoey, ML (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM megan.hoey@us.army.mil NR 7 TC 14 Z9 14 U1 2 U2 15 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 11 PY 2010 VL 97 IS 15 AR 153104 DI 10.1063/1.3499661 PG 3 WC Physics, Applied SC Physics GA 667TM UT WOS:000283216900055 ER PT J AU Larkin, EA Stiles, BG Ulrich, RG AF Larkin, Eileen A. Stiles, Bradley G. Ulrich, Robert G. TI Inhibition of Toxic Shock by Human Monoclonal Antibodies against Staphylococcal Enterotoxin B SO PLOS ONE LA English DT Article ID OF-THE-LITERATURE; INTRAVENOUS IMMUNOGLOBULIN; CROSS-REACTIVITY; MURINE MODEL; DOUBLE-BLIND; IN-VITRO; AUREUS; SUPERANTIGENS; INFECTIONS; RESISTANT AB Background: Staphylococcus aureus is implicated in many opportunistic bacterial infections around the world. Rising antibiotic resistance and few alternative methods of treatment are just two looming problems associated with clinical management of S. aureus. Among numerous virulence factors produced by S. aureus, staphylococcal enterotoxin (SE) B is a secreted protein that binds T-cell receptor and major histocompatibility complex class II, potentially causing toxic shock mediated by pathological activation of T cells. Recombinant monoclonal antibodies that target SEB and block receptor interactions can be of therapeutic value. Methodology/Principal Findings: The inhibitory and biophysical properties of ten human monoclonal antibodies, isolated from a recombinant library by panning against SEB vaccine (STEBVax), were examined as bivalent Fabs and native full-length IgG (Mab). The best performing Fabs had binding affinities equal to polyclonal IgG, low nanomolar IC(50)s against SEB in cell culture assays, and protected mice from SEB-induced toxic shock. The orthologous staphylococcal proteins, SEC1 and SEC2, as well as streptococcal pyrogenic exotoxin C were recognized by several Fabs. Four Fabs against SEB, with the lowest IC(50)s, were converted into native full-length Mabs. Although SEB-binding kinetics were identical between each Fab and respective Mab, a 250-fold greater inhibition of SEB-induced T-cell activation was observed with two Mabs. Conclusions/Significance: Results suggest that these human monoclonal antibodies possess high affinity, target specificity, and toxin neutralization qualities essential for any therapeutic agent. C1 [Larkin, Eileen A.; Stiles, Bradley G.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD USA. [Larkin, Eileen A.; Ulrich, Robert G.] Hood Coll, Dept Biomed Sci, Frederick, MD 21701 USA. [Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA USA. RP Larkin, EA (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD USA. EM bstiles@wilson.edu; rulrich@bioanalysis.org FU Joint Science and Technology Office [3.1003 07 RD B] FX Funding was provided by The Joint Science and Technology Office 3.1003 07 RD B. This research was supported in part by an appointment of EAL to the Postgraduate Research Participation Program at the Medical Research Institute of Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 65 TC 25 Z9 26 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 11 PY 2010 VL 5 IS 10 AR e13253 DI 10.1371/journal.pone.0013253 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 661SK UT WOS:000282748100006 PM 20949003 ER PT J AU Toole, JM Timmermans, ML Perovich, DK Krishfield, RA Proshutinsky, A Richter-Menge, JA AF Toole, J. M. Timmermans, M. -L. Perovich, D. K. Krishfield, R. A. Proshutinsky, A. Richter-Menge, J. A. TI Influences of the ocean surface mixed layer and thermohaline stratification on Arctic Sea ice in the central Canada Basin SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID NEAR-INERTIAL MOTIONS; ENERGY FLUX; INTERNAL WAVES; BEAUFORT SEA; PACK ICE; WIND; VARIABILITY; MODELS; COVER AB Variations in the Arctic central Canada Basin mixed layer properties are documented based on a subset of nearly 6500 temperature and salinity profiles acquired by Ice-Tethered Profilers during the period summer 2004 to summer 2009 and analyzed in conjunction with sea ice observations from ice mass balance buoys and atmosphere-ocean heat flux estimates. The July-August mean mixed layer depth based on the Ice-Tethered Profiler data averaged 16 m (an overestimate due to the Ice-Tethered Profiler sampling characteristics and present analysis procedures), while the average winter mixed layer depth was only 24 m, with individual observations rarely exceeding 40 m. Guidance interpreting the observations is provided by a 1-D ocean mixed layer model. The analysis focuses attention on the very strong density stratification at the base of the mixed layer in the Canada Basin that greatly impedes surface layer deepening and thus limits the flux of deep ocean heat to the surface that could influence sea ice growth/decay. The observations additionally suggest that efficient lateral mixed layer restratification processes are active in the Arctic, also impeding mixed layer deepening. C1 [Toole, J. M.; Krishfield, R. A.; Proshutinsky, A.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Perovich, D. K.; Richter-Menge, J. A.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Timmermans, M. -L.] Yale Univ, New Haven, CT 06520 USA. RP Toole, JM (reprint author), Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. RI Timmermans, Mary-Louise/N-5983-2014 FU U. S. National Science Foundation; Woods Hole Oceanographic Institution; National Science Foundation; National Oceanographic and Atmospheric Administration FX We thank two anonymous reviewers and the associate editor for their detailed constructive comments on our manuscript and I. Polyakov, L. Rainville, and M. Steele for their additional suggestions. The ITP data analyzed here were collected and made available by the Ice-Tethered Profiler Program based at the Woods Hole Oceanographic Institution (http://www.whoi.edu/itp). We thank the many technicians and sea-going personnel who assisted with the instrument deployments, particularly the officers and crew of the CCGS Louis S. St-Laurent. Support for the ITP program and this study was provided by the U. S. National Science Foundation and the Woods Hole Oceanographic Institution. Support for the IMB program came from the National Science Foundation and the National Oceanographic and Atmospheric Administration. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the National Science Foundation or the National Oceanographic and Atmospheric Administration. NR 38 TC 75 Z9 76 U1 1 U2 16 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD OCT 8 PY 2010 VL 115 AR C10018 DI 10.1029/2009JC005660 PG 14 WC Oceanography SC Oceanography GA 690MX UT WOS:000285010000002 ER PT J AU Keiser, PB Gibbs, BT Coster, TS Moran, EE Stoddard, MB Labrie, JE Schmiel, DH Pinto, V Chen, P Zollinger, WD AF Keiser, Paul B. Gibbs, Barnett T. Coster, Trinka S. Moran, E. Ellen Stoddard, Mark B. Labrie, Joseph E., III Schmiel, Deborah H. Pinto, Valerian Chen, Ping Zollinger, Wendell D. TI A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA SO VACCINE LA English DT Article DE Neisseria; NOMV; lpxL2; Lipooligosaccharide; OpcA ID NEISSERIA-MENINGITIDIS; UNITED-STATES; ANTIBODIES; MICE; DISEASE AB This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a IpxL2(-)synX(-)mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adjuvant, and 50 mcg) to receive three intramuscular injections at 0, 6 and 24 weeks. Specific local and systemic adverse events (AEs) were solicited by diary and at visits on days 1, 2, 7 and 14 after each vaccination and at the end of the study at 30 weeks. Blood chemistries, complete blood count, and coagulation studies were measured on each vaccination day and again two days later. Blood for antibody measurements and bactericidal assays were drawn 0, 14, and 42 days after each vaccination. The proportion of volunteers who developed a fourfold or greater increase in serum bactericidal activity (SBA) to the wild-type parent of the vaccine strain with high opcA expression at 6 weeks after the third dose was 12/26 (0.46, 95% confidence interval 0.27-0.65). Antibody levels to OpcA were significantly higher in vaccine responders than in non-responders (p = 0.008), and there was a trend for higher antibody levels to the lipooligosaccharide (LOS) (p = 0.059). Bactericidal depletion assays on sera from volunteers with high-titer responses also indicate a major contribution of anti-OpcA and anti-LOS antibodies to the bactericidal response. These results suggest that genetically modified NOMV vaccines can induce protection against group B meningococcus. Published by Elsevier Ltd. C1 [Keiser, Paul B.; Moran, E. Ellen; Labrie, Joseph E., III; Schmiel, Deborah H.; Pinto, Valerian; Zollinger, Wendell D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gibbs, Barnett T.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Coster, Trinka S.] USA, Off Surg Gen, Silver Spring, MD USA. [Stoddard, Mark B.] Univ Alabama, Sch Med, Birmingham, AL USA. [Chen, Ping] NIAID, Div Microbiol & Infect Dis, NIH, Bethesda, MD 20892 USA. RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM paul.keiser@us.army.mil RI Schmiel, Deborah/B-2875-2011; Zollinger, Wendell/B-2887-2011 FU Military Infectious Disease Research Program FX This study was funded by the Military Infectious Disease Research Program, Fort Detrick, MD. Disclosure: Presented in part as a poster at the International Pathogenic Neisseria Conference, September 2008 in Rotterdam, Netherlands. NR 27 TC 28 Z9 28 U1 2 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 8 PY 2010 VL 28 IS 43 BP 6970 EP 6976 DI 10.1016/j.vaccine.2010.08.048 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 677DW UT WOS:000283970300004 PM 20732470 ER PT J AU Chaitankar, V Ghosh, P Perkins, EJ Gong, P Zhang, C AF Chaitankar, Vijender Ghosh, Preetam Perkins, Edward J. Gong, Ping Zhang, Chaoyang TI Time lagged information theoretic approaches to the reverse engineering of gene regulatory networks SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT 7th Annual Midsouth Computational Biology and Bioinformatics (MCBIOS) CY FEB 19-20, 2010 CL Jonesboro, AR ID MINIMUM DESCRIPTION LENGTH; KEGG; PRINCIPLE; GENOMES; MODELS AB Background: A number of models and algorithms have been proposed in the past for gene regulatory network (GRN) inference; however, none of them address the effects of the size of time-series microarray expression data in terms of the number of time-points. In this paper, we study this problem by analyzing the behaviour of three algorithms based on information theory and dynamic Bayesian network (DBN) models. These algorithms were implemented on different sizes of data generated by synthetic networks. Experiments show that the inference accuracy of these algorithms reaches a saturation point after a specific data size brought about by a saturation in the pair-wise mutual information (MI) metric; hence there is a theoretical limit on the inference accuracy of information theory based schemes that depends on the number of time points of micro-array data used to infer GRNs. This illustrates the fact that MI might not be the best metric to use for GRN inference algorithms. To circumvent the limitations of the MI metric, we introduce a new method of computing time lags between any pair of genes and present the pair-wise time lagged Mutual Information (TLMI) and time lagged Conditional Mutual Information (TLCMI) metrics. Next we use these new metrics to propose novel GRN inference schemes which provides higher inference accuracy based on the precision and recall parameters. Results: It was observed that beyond a certain number of time-points (i.e., a specific size) of micro-array data, the performance of the algorithms measured in terms of the recall-to-precision ratio saturated due to the saturation in the calculated pair-wise MI metric with increasing data size. The proposed algorithms were compared to existing approaches on four different biological networks. The resulting networks were evaluated based on the benchmark precision and recall metrics and the results favour our approach. Conclusions: To alleviate the effects of data size on information theory based GRN inference algorithms, novel time lag based information theoretic approaches to infer gene regulatory networks have been proposed. The results show that the time lags of regulatory effects between any pair of genes play an important role in GRN inference schemes. C1 [Chaitankar, Vijender; Ghosh, Preetam; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Gong, Ping] SpecPro Inc, Vicksburg, MS 39180 USA. RP Zhang, C (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. EM chaoyang.zhang@usm.edu FU NSF [EPS-0903787]; US Army Corps of Engineers [W912HZ-08-2-0011] FX This work was supported by NSF through contract EPS-0903787 awarded to CZ and PG1, and the US Army Corps of Engineers Environmental Quality Program under contract # W912HZ-08-2-0011. Permission was granted by the Chief of Engineers to publish this information. NR 28 TC 11 Z9 13 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 7 PY 2010 VL 11 SU 6 AR S19 DI 10.1186/1471-2105-11-S6-S19 PG 14 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 759CB UT WOS:000290216600019 PM 20946602 ER PT J AU Rawat, A Gust, KA Elasri, MO Perkins, EJ AF Rawat, Arun Gust, Kurt A. Elasri, Mohamed O. Perkins, Edward J. TI Quail Genomics: a knowledgebase for Northern bobwhite SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT 7th Annual Midsouth Computational Biology and Bioinformatics (MCBIOS) CY FEB 19-20, 2010 CL Jonesboro, AR ID COLINUS-VIRGINIANUS; GENE ONTOLOGY; ANNOTATION; TOOL; ALIGNMENT; EXPOSURE; PLATFORM; PIPELINE AB Background: The Quail Genomics knowledgebase (http://www.quailgenomics.info) has been initiated to share and develop functional genomic data for Northern bobwhite (Colinus virginianus). This web-based platform has been designed to allow researchers to perform analysis and curate genomic information for this non-model species that has little supporting information in GenBank. Description: A multi-tissue, normalized cDNA library generated for Northern bobwhite was sequenced using 454 Life Sciences next generation sequencing. The Quail Genomics knowledgebase represents the 478,142 raw ESTs generated from the sequencing effort in addition to assembled nucleotide and protein sequences including 21,980 unigenes annotated with meta-data. A normalized MySQL relational database was established to provide comprehensive search parameters where meta-data can be retrieved using functional and structural information annotation such as gene name, pathways and protein domain. Additionally, blast hit cutoff levels and microarray expression data are available for batch searches. A Gene Ontology (GO) browser from Amigo is locally hosted providing 8,825 unigenes that are putative orthologs to chicken genes. In an effort to address over abundance of Northern bobwhite unigenes (71,384) caused by non-overlapping contigs and singletons, we have built a pipeline that generates scaffolds/supercontigs by aligning partial sequence fragments against the indexed protein database of chicken to build longer sequences that can be visualized in a web browser. Conclusion: Our effort provides a central repository for storage and a platform for functional interrogation of the Northern bobwhite sequences providing comprehensive GO annotations, meta-data and a scaffold building pipeline. The Quail Genomics knowledgebase will be integrated with Japanese quail (Coturnix coturnix) data in future builds and incorporate a broader platform for these avian species. C1 [Gust, Kurt A.; Perkins, Edward J.] US Army Corps Engineers, Environm Lab, EP P, Vicksburg, MS USA. [Rawat, Arun; Elasri, Mohamed O.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. RP Perkins, EJ (reprint author), US Army Corps Engineers, Environm Lab, EP P, Vicksburg, MS USA. EM Edward.J.Perkins@usace.army.mil OI Rawat, Arun/0000-0003-0540-2044 FU Mississippi Functional Genomics Network (NIH/NCRR) [P20 RR016476]; U. S. Army Environmental Quality/Installations Research Program [W912HZ-08-C-0032] FX We gratefully acknowledge the support of the Mississippi Functional Genomics Network (NIH/NCRR P20 RR016476) and grant #W912HZ-08-C-0032 from the U. S. Army Environmental Quality/Installations Research Program. We thank Glover George for assisting in establishing MPI-Blast and use of http://cluster.vislab.usm.edu. Permission was granted from the Chief of Engineers to publish this information. NR 24 TC 8 Z9 8 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 7 PY 2010 VL 11 SU 6 AR S13 DI 10.1186/1471-2105-11-S6-S13 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 759CB UT WOS:000290216600013 PM 20946596 ER PT J AU Wren, JD Kupfer, DM Perkins, EJ Bridges, S Berleant, D AF Wren, Jonathan D. Kupfer, Doris M. Perkins, Edward J. Bridges, Susan Berleant, Daniel TI Proceedings of the 2010 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference SO BMC BIOINFORMATICS LA English DT Editorial Material ID GENOME-WIDE ASSOCIATION; SYSTEMS BIOLOGY; SNP DATA; PROTEIN; IDENTIFICATION; DATABASE; NETWORKS; TOOL; INFORMATION; MICROARRAYS C1 [Wren, Jonathan D.] Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, Oklahoma City, OK 73104 USA. [Kupfer, Doris M.] FAA, Aerosp Med Inst, Oklahoma City, OK 73169 USA. [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Bridges, Susan] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS USA. [Berleant, Daniel] Univ Arkansas, Dept Informat Sci, Little Rock, AR 72204 USA. RP Wren, JD (reprint author), Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM jdwren@gmail.com RI Wren, Jonathan/E-5611-2011 OI Wren, Jonathan/0000-0003-2776-3545 NR 69 TC 0 Z9 0 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 7 PY 2010 VL 11 SU 6 AR S1 DI 10.1186/1471-2105-11-S6-S1 PG 5 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 759CB UT WOS:000290216600001 PM 20946592 ER PT J AU McKeon, SN Lehr, MA Wilkerson, RC Ruiz, JF Sallum, MA Lima, JBP Povoa, MM Conn, JE AF McKeon, Sascha N. Lehr, Margaret A. Wilkerson, Richard C. Ruiz, John F. Sallum, Maria A. Lima, Jose B. P. Povoa, Marinete M. Conn, Jan E. TI Lineage divergence detected in the malaria vector Anopheles marajoara (Diptera: Culicidae) in Amazonian Brazil SO MALARIA JOURNAL LA English DT Article ID CHAIN-REACTION IDENTIFICATION; INTERNAL TRANSCRIBED SPACER; ALBITARSIS COMPLEX DIPTERA; CYTOCHROME-OXIDASE-I; MITOCHONDRIAL-DNA; MOLECULAR PHYLOGENY; BIOLOGICAL IDENTIFICATIONS; COMPARATIVE SUSCEPTIBILITY; GENETIC DIFFERENTIATION; INSECTICIDE RESISTANCE AB Background: Cryptic species complexes are common among anophelines. Previous phylogenetic analysis based on the complete mtDNA COI gene sequences detected paraphyly in the Neotropical malaria vector Anopheles marajoara. The "Folmer region" detects a single taxon using a 3% divergence threshold. Methods: To test the paraphyletic hypothesis and examine the utility of the Folmer region, genealogical trees based on a concatenated (white + 3' COI sequences) dataset and pairwise differentiation of COI fragments were examined. The population structure and demographic history were based on partial COI sequences for 294 individuals from 14 localities in Amazonian Brazil. 109 individuals from 12 localities were sequenced for the nDNA white gene, and 57 individuals from 11 localities were sequenced for the ribosomal DNA (rDNA) internal transcribed spacer 2 (ITS2). Results: Distinct A. marajoara lineages were detected by combined genealogical analysis and were also supported among COI haplotypes using a median joining network and AMOVA, with time since divergence during the Pleistocene (< 100,000 ya). COI sequences at the 3' end were more variable, demonstrating significant pairwise differentiation (3.82%) compared to the more moderate 2.92% detected by the Folmer region. Lineage 1 was present in all localities, whereas lineage 2 was restricted mainly to the west. Mismatch distributions for both lineages were bimodal, likely due to multiple colonization events and spatial expansion (similar to 798 - 81,045 ya). There appears to be gene flow within, not between lineages, and a partial barrier was detected near Rio Jari in Amapa state, separating western and eastern populations. In contrast, both nDNA data sets (white gene sequences with or without the retention of the 4th intron, and ITS2 sequences and length) detected a single A. marajoara lineage. Conclusions: Strong support for combined data with significant differentiation detected in the COI and absent in the nDNA suggest that the divergence is recent, and detectable only by the faster evolving mtDNA. A within subgenus threshold of >2% may be more appropriate among sister taxa in cryptic anopheline complexes than the standard 3%. Differences in demographic history and climatic changes may have contributed to mtDNA lineage divergence in A. marajoara. C1 [McKeon, Sascha N.; Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12201 USA. [Lehr, Margaret A.] Univ Vermont, Dept Biol, Burlington, VT 05405 USA. [Wilkerson, Richard C.; Ruiz, John F.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. [Sallum, Maria A.] Univ Sao Paulo, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil. [Lima, Jose B. P.] Fiocruz MS, IOC, Lab Fisiol & Controle Artropodes Vetores, BR-21045900 Rio De Janeiro, Brazil. [Povoa, Marinete M.] Secretaria Vigilancia Saude MS, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria, BR-67030000 Ananindeua, Para, Brazil. [Conn, Jan E.] New York State Dept Hlth, Griffin Lab, Wadsworth Ctr, Slingerlands, NY 12159 USA. RP Conn, JE (reprint author), SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Empire State Plaza, Albany, NY 12201 USA. EM jconn@wadsworth.org RI Sallum, Maria/B-8537-2012; OI Conn, Jan/0000-0002-5301-7020 FU Instituto Evandro Chagas, Ananindeua, Para, Brazil; NIH [1T32AI05532901A1, 2R01 A154139] FX We thank M Povoa's research group at Instituto Evandro Chagas/SVS/MS in Ananindeua, Para, Brazil as well as Rosa and Roger Hutchings, Instituto Nacional de Pesquisas da Amazonia, Manaus, Brazil, for assistance in mosquito collection and logistics. We also appreciate the help of W. Kilpatrick, UVM, with analysis and interpretation of the eastern Amazon data early on. Funding for this study was provided by Instituto Evandro Chagas, Ananindeua, Para, Brazil and NIH grants 1T32AI05532901A1, "Training in Biodefense and Emerging Infectious Disease" and NIH 2R01 A154139 to JEC. Permission to collect in the Amazon basin was provided by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) processo: CMC 028/04 - Expedicao Cientifica and IBAMA RMX 021/04 (Projeto: ? Biologia e sistematica de vetores de malaria no Brasil: genetica e ecologia?). NR 115 TC 19 Z9 19 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 7 PY 2010 VL 9 AR 271 DI 10.1186/1475-2875-9-271 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 668IQ UT WOS:000283262200001 PM 20929572 ER PT J AU Waterman, BR Owens, BD Davey, S Zacchilli, MA Belmont, PJ AF Waterman, Brian R. Owens, Brett D. Davey, Shaunette Zacchilli, Michael A. Belmont, Philip J., Jr. TI The Epidemiology of Ankle Sprains in the United States SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID CRUCIATE LIGAMENT INJURY; FEMALE ARMY TRAINEES; RISK-FACTORS; EMERGENCY-DEPARTMENTS; ATHLETIC POPULATION; FOOTBALL PLAYERS; TENDON RUPTURES; LATERAL ANKLE; SPORTS; SOCCER AB Background: Ankle sprain has been studied in athletic cohorts, but little is known of its epidemiology in the general population. A longitudinal, prospective epidemiological database was used to determine the incidence and demographic risk factors for ankle sprains presenting to emergency departments in the United States. It was our hypothesis that ankle sprain is influenced by sex, race, age, and involvement in athletics. Methods: The National Electronic Injury Surveillance System (NEISS) was queried for all ankle sprain injuries presenting to emergency departments between 2002 and 2006. Incidence rate ratios were then calculated with respect to age, sex, and race. Results: During the study period, an estimated 3,140,132 ankle sprains occurred among an at-risk population of 1,461,379,599 person-years for an incidence rate of 2.15 per 1000 person-years in the United States. The peak incidence of ankle sprain occurred between fifteen and nineteen years of age (7.2 per 1000 person-years). Males, compared with females, did not demonstrate an overall increased incidence rate ratio for ankle sprain (incidence rate ratio, 1.04; 95% confidence interval, 1.00 to 1.09). However, males between fifteen and twenty-four years old had a substantially higher incidence of ankle sprain than their female counterparts (incidence rate ratio, 1.53; 95% confidence interval, 1.41 to 1.66), whereas females over thirty years old had a higher incidence compared with their male counterparts (incidence rate ratio, 2.03; 95% confidence interval, 1.65 to 2.65). Compared with the Hispanic race, the black and white races were associated with substantially higher rates of ankle sprain (incidence rate ratio, 3.55 [95% confidence interval, 1.01 to 6.09] and 2.49 [95% confidence interval, 1.01 to 3.97], respectively). Nearly half of all ankle sprains (49.3%) occurred during athletic activity, with basketball (41.1%), football (9.3%), and soccer (7.9%) being associated with the highest percentage of ankle sprains during athletics. Conclusions: An age of ten to nineteen years old is associated with higher rates of ankle sprain. Males between fifteen and twenty-four years old have higher rates of ankle sprain than their female counterparts, whereas females over thirty years old have higher rates than their male counterparts. Half of all ankle sprains occur during athletic activity. Level of Evidence: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. C1 [Waterman, Brian R.] William Beaumont Army Med Ctr, Orthopaed Surg Serv, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA. US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Waterman, BR (reprint author), William Beaumont Army Med Ctr, Orthopaed Surg Serv, Dept Orthopaed Surg & Rehabil, 5005 N Piedras St, El Paso, TX 79920 USA. EM brian.waterman@amedd.army.mil OI Belmont, Philip/0000-0003-2618-199X NR 51 TC 163 Z9 172 U1 6 U2 45 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD OCT 6 PY 2010 VL 92A IS 13 BP 2279 EP 2284 DI 10.2106/JBJS.I.01537 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 675LN UT WOS:000283832300003 PM 20926721 ER PT J AU Gordon, WT O'Brien, FP Strauss, JE Andersen, RC Potter, BK AF Gordon, Wade T. O'Brien, Frederick P. Strauss, Joseph E. Andersen, Romney C. Potter, Benjamin K. TI Outcomes Associated with the Internal Fixation of Long-Bone Fractures Proximal to Traumatic Amputations SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID HETEROTOPIC OSSIFICATION; ENERGY-COST; AMBULATION; AMPUTEES; LEVEL AB Background: Preservation of optimal residual limb length following a traumatic amputation can be challenging. The purpose of this study was to determine if acceptable results can be achieved by definitive fixation of a long-bone fracture proximal to a traumatic amputation. Methods: We identified thirty-seven active-duty military service members who underwent internal fixation of a long-bone fracture. proximal to a traumatic amputation. Functional status was assessed with the Tegner activity level scale and prosthesis use. Secondary outcome measures were the development of nonunion, infection, and heterotopic ossification. Results: Twelve patients (32%) underwent amputation and fracture in the same osseous segment. Ten patients (27%) sustained bilateral traumatic amputations, and eight (22%) had a major fracture of the contralateral extremity. The median times to fracture fixation and amputation closure were twelve days and nineteen days, respectively, after the injury. The mean Tegner activity score was 3.32 (range, 1 to 6); patients with isolated extremity injuries had significantly higher Tegner scores than those with severe bilateral injuries (3.59 and 2.38, respectively; p = 0.04). Thirty-three patients (89%) developed an infection requiring surgical debridement. However, all fractures were treated until union occurred, and amputation level salvage was successful in all instances. Heterotopic ossification developed in twenty-eight patients (76%), with operative excision required in eleven patients (39%). Conclusions: High complication rates, but acceptable final results, can be achieved with internal fixation of a fracture proximal to a traumatic amputation to preserve functional joint levels or salvage residual limb length. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence. C1 [Gordon, Wade T.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gordon, WT (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2,Clin 5A Ortho, Washington, DC 20307 USA. EM wade.gordon@amedd.army.mil NR 28 TC 8 Z9 8 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD OCT 6 PY 2010 VL 92A IS 13 BP 2312 EP 2318 DI 10.2106/JBJS.I.00138 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 675LN UT WOS:000283832300008 PM 20926726 ER PT J AU Bromenshenk, JJ Henderson, CB Wick, CH Stanford, MF Zulich, AW Jabbour, RE Deshpande, SV McCubbin, PE Seccomb, RA Welch, PM Williams, T Firth, DR Skowronski, E Lehmann, MM Bilimoria, SL Gress, J Wanner, KW Cramer, RA AF Bromenshenk, Jerry J. Henderson, Colin B. Wick, Charles H. Stanford, Michael F. Zulich, Alan W. Jabbour, Rabih E. Deshpande, Samir V. McCubbin, Patrick E. Seccomb, Robert A. Welch, Phillip M. Williams, Trevor Firth, David R. Skowronski, Evan Lehmann, Margaret M. Bilimoria, Shan L. Gress, Joanna Wanner, Kevin W. Cramer, Robert A., Jr. TI Iridovirus and Microsporidian Linked to Honey Bee Colony Decline SO PLOS ONE LA English DT Article ID CHILO IRIDESCENT VIRUS; SPECTROMETRY-BASED PROTEOMICS; APIS-MELLIFERA L.; COLLAPSE DISORDER; NOSEMA-CERANAE; KAKUGO-VIRUS; MOSQUITO; TRANSMISSION; CLASSIFICATION; INDUCTION AB Background: In 2010 Colony Collapse Disorder (CCD), again devastated honey bee colonies in the USA, indicating that the problem is neither diminishing nor has it been resolved. Many CCD investigations, using sensitive genome-based methods, have found small RNA bee viruses and the microsporidia, Nosema apis and N. ceranae in healthy and collapsing colonies alike with no single pathogen firmly linked to honey bee losses. Methodology/Principal Findings: We used Mass spectrometry-based proteomics (MSP) to identify and quantify thousands of proteins from healthy and collapsing bee colonies. MSP revealed two unreported RNA viruses in North American honey bees, Varroa destructor-1 virus and Kakugo virus, and identified an invertebrate iridescent virus (IIV) (Iridoviridae) associated with CCD colonies. Prevalence of IIV significantly discriminated among strong, failing, and collapsed colonies. In addition, bees in failing colonies contained not only IIV, but also Nosema. Co-occurrence of these microbes consistently marked CCD in (1) bees from commercial apiaries sampled across the U. S. in 2006-2007, (2) bees sequentially sampled as the disorder progressed in an observation hive colony in 2008, and (3) bees from a recurrence of CCD in Florida in 2009. The pathogen pairing was not observed in samples from colonies with no history of CCD, namely bees from Australia and a large, non-migratory beekeeping business in Montana. Laboratory cage trials with a strain of IIV type 6 and Nosema ceranae confirmed that co-infection with these two pathogens was more lethal to bees than either pathogen alone. Conclusions/Significance: These findings implicate co-infection by IIV and Nosema with honey bee colony decline, giving credence to older research pointing to IIV, interacting with Nosema and mites, as probable cause of bee losses in the USA, Europe, and Asia. We next need to characterize the IIV and Nosema that we detected and develop management practices to reduce honey bee losses. C1 [Bromenshenk, Jerry J.] Univ Montana, Div Biol Sci, Missoula, MT 59812 USA. [Henderson, Colin B.] Univ Montana, Coll Technol, Missoula, MT USA. [Wick, Charles H.; Stanford, Michael F.; Zulich, Alan W.; Skowronski, Evan] USA, Edgewood Chem Biol Ctr, Edgewood Area, MD USA. [Jabbour, Rabih E.] Sci Applicat Int Corp, Abingdon, MD USA. [Deshpande, Samir V.] Sci Technol Corp, Edgewood, MD USA. [McCubbin, Patrick E.] OptiMetrics Inc, Abingdon, MD USA. [Bromenshenk, Jerry J.; Henderson, Colin B.; Seccomb, Robert A.; Welch, Phillip M.] Bee Alert Technol Inc, Missoula, MT USA. [Williams, Trevor] Inst Ecol AC, Xalapa, Veracruz, Mexico. [Firth, David R.] Univ Montana, Dept Informat Syst & Technol, Missoula, MT 59812 USA. [Lehmann, Margaret M.; Cramer, Robert A., Jr.] Montana State Univ, Dept Vet Mol Biol, Bozeman, MT 59717 USA. [Bilimoria, Shan L.] Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USA. [Gress, Joanna; Wanner, Kevin W.] Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA. [Deshpande, Samir V.] Towson Univ, Dept Comp & Informat Sci, Towson, MD USA. [Bilimoria, Shan L.] Texas Tech Univ, Ctr Biotechnol & Genom, Lubbock, TX 79409 USA. RP Bromenshenk, JJ (reprint author), Univ Montana, Div Biol Sci, Missoula, MT 59812 USA. EM beeresearch@aol.com RI Williams, Trevor/J-4239-2013; Williams, Trevor/F-1447-2011 OI Williams, Trevor/0000-0003-3414-3440; Williams, Trevor/0000-0003-3414-3440 FU Point Detection Branch of ECBC, Defense Threat Reduction Agency (DTRA); National Honey Board, California Almond Board [06-POLL8-Bromenshenk, 09-POLL10-Bromenshenk]; Foundation for the Preservation of the Honey Bee; US Army Medical Research and Material Command [W81XWH-04-C-0013]; California Beekeepers Association; Montana Agricultural Experiment Station in the laboratory of RAC FX Proteomics analysis was provided by the Point Detection Branch of ECBC under the auspices of the basic science program of the Defense Threat Reduction Agency (DTRA). Sampling and analysis was supported by the National Honey Board, California Almond Board (06-POLL8-Bromenshenk, 09-POLL10-Bromenshenk), The Foundation for the Preservation of the Honey Bee, and the US Army Medical Research and Material Command (W81XWH-04-C-0013), with data processing and statistical analysis by the US Army Night Vision Laboratory (W909MY-06-C-0037). Project Apis m. is funding confirmatory inoculation studies. Work related to these studies was supported by the California Beekeepers Association and the Montana Agricultural Experiment Station in the laboratory of RAC. These companies and the other listed funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 95 Z9 110 U1 7 U2 99 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 6 PY 2010 VL 5 IS 10 AR e13181 DI 10.1371/journal.pone.0013181 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 659LQ UT WOS:000282568400008 PM 20949138 ER PT J AU Huang, YM Mathis, WN Wilkerson, RC AF Huang, Yiau-Min Mathis, Wayne N. Wilkerson, Richard C. TI Coetzeemyia, a new subgenus of Aedes, and a redescription of the holotype female of Aedes (Coetzeemyia) fryeri (Theobald) (Diptera: Culicidae) SO ZOOTAXA LA English DT Article DE Coetzeemyia; new subgenus; Aedes fryeri; Ae. dufouri; Ochlerotatus; Levua; Ae. (Levua) geoskusea (=suvae); characteristics; systematics; Culicidae; Aldabra Island ID ALLIED TAXA DIPTERA; LIFE STAGES; MORPHOLOGICAL DATA; AEDINI DIPTERA; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Coetzeemyia, a new subgenus of Aedes Meigen (in the broad traditional sense, pre-Reinert 2000), is characterized and diagnosed. Aedes fryeri (Theobald) is removed from the subgenus Levua Stone and Bohart (genus Levua of Reinert et al. 2004) and placed in the new monotypic subgenus Coetzeemyia as its type species by present designation. Recognition of Coetzeemyia is based in part on a cladistic analysis of 16 species: seven outgroup species (four non-Aedini species and 3 aedine species) and nine within group species, including the three species that had been included in Levua and six other species belonging to three related subgenera in Aedes (Geoskusea Edwards, Rhinoskusea Edwards, and Ochlerotatus-Lynch Arribalzaga). The type female and the male genitalia of Ae. fryeri are redescribed and illustrated. Its affinity to other subgenera of the genus Aedes is discussed. Information on the type data, distribution, bionomics, medical importance, and taxonomy of this species are presented. Some morphological characteristics of adults of the subgenera Ochlerotatus and Levua of Aedes are tabulated. Based on this cladistic analysis, it is evident that Levua is a monotypic lineage represented by a single known species, Ae. geoskusea. Aedes dufouri is transferred back to the subgenus Ochlerotatus and is distinguished from other congeners of this subgenus. C1 [Huang, Yiau-Min; Mathis, Wayne N.] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA. [Wilkerson, Richard C.] Smithsonian Inst, WRBU, Washington, DC 20013 USA. [Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. EM huangy@si.edu; mathisw@si.edu; wilkersonr@si.edu FU Department of Entomology, Smithsonian Institution; Walter Reed Army Institute of Research and the Smithsonian Institution FX We express our sincere appreciation and gratitude to the Department of Entomology, Smithsonian Institution for providing funding for the publication; to Drs. Leopoldo M. Rueda and Desmond Foley, Walter Reed Biosystematics Unit (WRBU), for critically reviewing this manuscript, and for their valuable comments. We also thank Ms. Karolyn Darrow, Scientific Illustrator, Department of Entomology, Smithsonian Institution, who helped produce the cladogram (Fig. 4).; This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The material to be published reflects the views of the authors and should not be construed to represent those of the Department of the Army or the Department of Defense. NR 28 TC 4 Z9 4 U1 0 U2 0 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD OCT 6 PY 2010 IS 2638 BP 1 EP 24 PG 24 WC Zoology SC Zoology GA 660LV UT WOS:000282645300001 ER PT J AU Smith, NK AF Smith, Norman K. TI Real Heroes: Those Who Speak Out SO NATION LA English DT Letter C1 [Smith, Norman K.] USA, Exton, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATION CO INC PI NEW YORK PA 33 IRVING PLACE, 8TH FLOOR, NEW YORK, NY 10003 USA SN 0027-8378 J9 NATION JI Nation PD OCT 4 PY 2010 VL 291 IS 14 BP 2 EP 2 PG 1 WC Political Science SC Government & Law GA 652QL UT WOS:000282024800002 ER PT J AU Wilchinsky, AV Feltham, DL Hopkins, MA AF Wilchinsky, Alexander V. Feltham, Daniel L. Hopkins, Mark A. TI Effect of shear rupture on aggregate scale formation in sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID TENSILE-STRENGTH; IN-SITU; FRACTURE; FAILURE; COMPRESSION; SATELLITE; RHEOLOGY AB A discrete element model is used to study shear rupture of sea ice under convergent wind stresses. The model includes compressive, tensile, and shear rupture of viscous elastic joints connecting floes that move under the action of the wind stresses. The adopted shear rupture is governed by Coulomb's criterion. The ice pack is a 400 km long square domain consisting of 4 km size floes. In the standard case with tensile strength 10 times smaller than the compressive strength, under uniaxial compression the failure regime is mainly shear rupture with the most probable scenario corresponding to that with the minimum failure work. The orientation of cracks delineating formed aggregates is bimodal with the peaks around the angles given by the wing crack theory determining diamond-shaped blocks. The ice block (floe aggregate) size decreases as the wind stress gradient increases since the elastic strain energy grows faster leading to a higher speed of crack propagation. As the tensile strength grows, shear rupture becomes harder to attain and compressive failure becomes equally important leading to elongation of blocks perpendicular to the compression direction and the blocks grow larger. In the standard case, as the wind stress confinement ratio increases the failure mode changes at a confinement ratio within 0.2-0.4, which corresponds to the analytical critical confinement ratio of 0.32. Below this value, the cracks are bimodal delineating diamond shape aggregates, while above this value failure becomes isotropic and is determined by small-scale stress anomalies due to irregularities in floe shape. C1 [Wilchinsky, Alexander V.; Feltham, Daniel L.] UCL, Natl Ctr Earth Observat, Ctr Polar Observat & Modelling, London WC1E 6BT, England. [Hopkins, Mark A.] USA, CRREL, Corps Engineers, Hanover, NH 03755 USA. [Feltham, Daniel L.] British Antarctic Survey, Cambridge CB3 0ET, England. RP Wilchinsky, AV (reprint author), UCL, Natl Ctr Earth Observat, Ctr Polar Observat & Modelling, Gower St, London WC1E 6BT, England. EM aw@cpom.ucl.ac.uk; dlf@cpom.ucl.ac.uk; mark.a.hopkins@usace.army.mil FU Leverhulme Trust FX D. L. Feltham acknowledges financial support made available by the Leverhulme Trust by the award of a research prize. NR 27 TC 11 Z9 12 U1 1 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD OCT 2 PY 2010 VL 115 AR C10002 DI 10.1029/2009JC006043 PG 13 WC Oceanography SC Oceanography GA 658TB UT WOS:000282511200005 ER PT J AU Molloy, JW Calcagno, CJ Williams, CD Harrison, SA AF Molloy, Jeffrey W. Calcagno, Christopher J. Williams, Christopher D. Harrison, Stephen A. TI ASSOCIATION OF COFFEE CONSUMPTION WITH FATTY LIVER DISEASE, NASH, AND DEGREE OF HEPATIC FIBROSIS SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Molloy, Jeffrey W.; Calcagno, Christopher J.; Williams, Christopher D.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 627 BP 621A EP 621A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775600626 ER PT J AU Hayward, CS Lockwood, J Williams, CD Cole, RE Torres, DM Harrison, SA AF Hayward, Carly S. Lockwood, Josh Williams, Christopher D. Cole, Renee E. Torres, Dawn M. Harrison, Stephen A. TI LIFESTYLE MODIFICATION AND NAFLD: A PROSPECTIVE, RANDOMIZED TRIAL SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Lockwood, Josh; Williams, Christopher D.; Cole, Renee E.; Torres, Dawn M.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hayward, Carly S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 629 BP 622A EP 622A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775600628 ER PT J AU Domanski, JP Park, S Harrison, SA AF Domanski, Jeremy P. Park, Stephen Harrison, Stephen A. TI CARDIOVASCULAR DISEASE AND NAFLD: DOES HISTOLOGIC SEVERITY MATTER? SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Domanski, Jeremy P.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Park, Stephen] SAMMC, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 639 BP 627A EP 627A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775600638 ER PT J AU Touzin, NT Bush, KN Williams, CD Harrison, SA AF Touzin, Nadege T. Bush, Kelvin N. Williams, Christopher D. Harrison, Stephen A. TI PREVALENCE OF COLONIC ADENOMAS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Touzin, Nadege T.; Williams, Christopher D.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Bush, Kelvin N.] SAMMC, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 697 BP 653A EP 653A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775601016 ER PT J AU Vierling, JM Prabhakar, A Han, JA Harrison, SA AF Vierling, John M. Prabhakar, Avinash Han, Jian Harrison, Stephen A. TI VIROLOGIC AND METABOLIC RESPONSES IN CHRONIC HEPATITIS C (CHC) GENOTYPE 1 (G1) PATIENTS WITH INSULIN RESISTANCE (IR) TREATED WITH PIOGLITAZONE (PIO) AND PEGINTERFERON ALFA-2A PLUS RIBAVIRIN (P/R) - FINAL RESULTS OF WEEK 12 EARLY VIROLOGIC RESPONSE SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Vierling, John M.] Baylor Coll Med, Houston, TX 77030 USA. [Prabhakar, Avinash; Han, Jian] Genentech Inc, San Francisco, CA USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 808 BP 707A EP 707A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775601128 ER PT J AU Harrison, SA Abdurakhmanov, D Shiffman, ML Bakulin, IG Mazur, WW Rodriguez-Torres, M Silva, GF Cheinquer, H Messinger, D Tatsch, F Reddy, R AF Harrison, Stephen A. Abdurakhmanov, Djamal Shiffman, Mitchell L. Bakulin, Igor G. Mazur, Wlodzimierz W. Rodriguez-Torres, Maribel Silva, Giovanni Faria Cheinquer, Hugo Messinger, Diethelm Tatsch, Fernando Reddy, Rajender TI SUSTAINED VIROLOGIC RESPONSE (SVR) RATES ARE HIGHER AMONG HEPATITIS C VIRUS (HCV) G1 PATIENTS WITH ELEVATED LOW-DENSITY LIPOPROTEIN (LDL) LEVELS WHEN TREATED WITH INTENSIFIED DOSES OF PEGINTERFERON ALFA-2A (40KD) (PEGASYS) PLUS RIBAVIRIN (RBV) SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Abdurakhmanov, Djamal] Moscow Med Acad, Moscow, Russia. [Shiffman, Mitchell L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA. [Bakulin, Igor G.] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia. [Mazur, Wlodzimierz W.] Med Univ Silesia, Chorzow, Poland. [Silva, Giovanni Faria] Botucatu Sch Med, Botucatu, SP, Brazil. [Cheinquer, Hugo] Hosp Clin Porto Alegre, Porto Alegre, Brazil. [Messinger, Diethelm] IST GmbH, Mannheim, Germany. [Tatsch, Fernando] Roche, Basel, Switzerland. [Reddy, Rajender] Univ Penn, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 921 BP 763A EP 763A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775601240 ER PT J AU Martone, AF Delp, EJ AF Martone, Anthony F. Delp, Edward J. TI Transcript synchronization using local dynamic programming SO JOURNAL OF ELECTRONIC IMAGING LA English DT Article ID SPEECH TRANSCRIPTS; VIDEO AB A local text alignment algorithm is introduced in this work for synchronizing transcripts. The proposed algorithm can be used for any transcript alignment process where high computational complexity is a concern. Dynamic programming is typically used to align a set of transcripts: however, the computational complexity of dynamic programming is high. To reduce the computational complexity, a local dynamic programming algorithm is introduced that aligns subsections of the transcripts. Aligning subsections of the transcripts greatly reduces the information needed for accurate synchronization. The information is reduced because it is not necessary to compare all words between the two transcripts. For example, words at the beginning of one transcript would not be compared to the words at the end of the other transcript. The subsection size is dependent on the total number of alignment errors between the transcripts. It is shown that the computational complexity of the proposed local dynamic programming algorithm is greatly reduced while preserving alignment accuracy. (C) 2010 SPIE and IS&T. [DOI: 10.1117/1.3504350] C1 [Martone, Anthony F.] USA, Res Lab, Adelphi, MD 20783 USA. [Delp, Edward J.] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA. [Delp, Edward J.] Purdue Univ, Sch Biomed Engn, W Lafayette, IN 47907 USA. RP Martone, AF (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Delp, Edward/C-3616-2013 OI Delp, Edward/0000-0002-2909-7323 FU C-SPAN Archives FX This work was partially supported by a grant from the C-SPAN Archives. NR 31 TC 0 Z9 0 U1 0 U2 2 PU IS&T & SPIE PI BELLINGHAM PA 1000 20TH ST, BELLINGHAM, WA 98225 USA SN 1017-9909 EI 1560-229X J9 J ELECTRON IMAGING JI J. Electron. Imaging PD OCT-DEC PY 2010 VL 19 IS 4 AR 043011 DI 10.1117/1.3504350 PG 11 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA 700LW UT WOS:000285744400013 ER PT J AU Murphy, D Barry, C Mead, J Zukas, W AF Murphy, Dan Barry, Carol Mead, Joey Zukas, Walter TI THE EFFECT OF MIXED FILLER SIZES ON THE FIBER DIAMETER OF ELECTROSPUN BUTYL RUBBER FORMULATIONS SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article; Proceedings Paper CT Fall 176th Technical Meeting of the Rubber-Division of the American-Chemical-Society CY OCT 13-15, 2009 CL Pittsburgh, PA SP Amer Chem Soc, Rubber Div ID NANOFIBERS; MEMBRANES AB Electrospinning of thermosetting elastomers is a method for developing nonwoven membranes with a microporous structure for use in dynamic applications (i.e., stretchable). These membranes have potential for chemical protective clothing applications. The most challenging concerns are the ability to control pore sizes, fiber diameter, permeability, and physical properties. We investigated the effect on fiber diameters as a ratio of two different carbon black particulate sizes. Carbon black N110 and N990 were incorporated at various percentages of total carbon black loading in a butyl rubber formulation. Higher levels of small particulates were found to give smaller and more consistent fiber diameters. Understanding of the effects of filler size and concentration on the electrospinning process will lead to the successful tailoring of nonwoven membranes with desired fiber diameter and pore size. C1 [Murphy, Dan; Barry, Carol; Mead, Joey] Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. [Zukas, Walter] USA, Soldiers Syst Ctr, Natick, MA 01760 USA. RP Murphy, D (reprint author), Univ Massachusetts, Dept Plast Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM murphydq@gmail.com NR 20 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 USA SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD OCT-DEC PY 2010 VL 83 IS 4 BP 349 EP 357 DI 10.5254/1.3481691 PG 9 WC Polymer Science SC Polymer Science GA 708ZD UT WOS:000286401900003 ER PT J AU Bermudez-Aguirre, D Yanez, JA Dunne, CP Davies, NM Barbosa-Canovas, GV AF Bermudez-Aguirre, Daniela Yanez, Jaime A. Dunne, C. Patrick Davies, Neal M. Barbosa-Canovas, Gustavo V. TI Study of strawberry flavored milk under pulsed electric field processing SO FOOD RESEARCH INTERNATIONAL LA English DT Article DE Allura Red; HPLC; Strawberry milk; Pulsed electric fields ID SYNTHETIC FOOD COLORANTS; ALLURA-RED; SHELF-LIFE; CHROMATOGRAPHY; PROTEIN; DRINKS AB Few studies exist on flavored milk processed by pulsed electric fields (PEF) The main concern is product stability This study aimed to analyze the degradation of coloring agent Allura Red in strawberry milk under PEF Four systems were tested containing Allura Red two commercial milks and two model systems PEF conditions were 40 kV/cm 48 pulses (2 5 mu s) and 55 C coloring agent was quantified via RP-HPLC After processing only minor changes were observed in color Allura Red concentration and pH During storage (32 d) at refrigerated conditions (4 C) commercial samples maintained pH above 6 Model systems dropped below pH 6 after 10 days of storage Color of samples showed important decrease in a* hue angle and chroma changed during storage HPLC analysis reported a bi-phasic effect in Allura Red concentrations versus time Concentration changed reaching a maximum value during the middle of storage possibly attributed to microbial growth pH reduction or interaction of proteins However PEF affected the stability of Allura Red in milk when additional ingredients were not added to the product (C) 2010 Elsevier Ltd All rights reserved C1 [Bermudez-Aguirre, Daniela; Barbosa-Canovas, Gustavo V.] Washington State Univ, Dept Biol Syst Engn, Pullman, WA 99164 USA. [Yanez, Jaime A.; Davies, Neal M.] Washington State Univ, Dept Pharmaceut Sci, Pullman, WA 99164 USA. [Dunne, C. Patrick] USA, Natick Soldier RDEC, Natick, MA 01760 USA. RP Barbosa-Canovas, GV (reprint author), Washington State Univ, Dept Biol Syst Engn, Pullman, WA 99164 USA. RI Yanez, Jaime/I-6972-2013; Davies, Neal/J-5811-2013 OI Yanez, Jaime/0000-0002-9713-1829; FU US Army Natick FX The authors acknowledge the economic support of this project by US Army Natick NR 21 TC 9 Z9 9 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0963-9969 J9 FOOD RES INT JI Food Res. Int. PD OCT PY 2010 VL 43 IS 8 BP 2201 EP 2207 DI 10.1016/j.foodres.2010.07.021 PG 7 WC Food Science & Technology SC Food Science & Technology GA 677FC UT WOS:000283973500035 ER PT J AU Furusato, B Parker, P Nydam, T Rice, K Srivastava, S Brassell, SA McLeod, DG Sesterhenn, IA AF Furusato, B. Parker, P. Nydam, T. Rice, K. Srivastava, S. Brassell, S. A. McLeod, D. G. Sesterhenn, I. A. TI Extensive multifocal prostatic adenocarcinomas (> 20) in radical prostatectomy specimens of young men SO HISTOPATHOLOGY LA English DT Meeting Abstract CT 28th International Congress of the International-Academy-of-Pathology CY OCT 10-15, 2010 CL Sao Paulo, BRAZIL SP Int Acad Pathol C1 [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Furusato, B.; Parker, P.; Nydam, T.; Rice, K.; Srivastava, S.; Brassell, S. A.; McLeod, D. G.; Sesterhenn, I. A.] Ctr Prostate Dis Res, Dept Surg, Uniformed Serv Univ, Bethesda, MD 20814 USA. [Parker, P.; Nydam, T.; Rice, K.; Brassell, S. A.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0309-0167 J9 HISTOPATHOLOGY JI Histopathology PD OCT PY 2010 VL 57 SU 1 MA 697 BP 251 EP 251 PG 1 WC Cell Biology; Pathology SC Cell Biology; Pathology GA 656GW UT WOS:000282317400694 ER PT J AU Legrand, FA McLeod, D Bilhartz, D Gittleman, M Adams, G Cochran, J Reiling, R Ruiz, H Karlin, G Owen, R Nguyen, AT Hwang, O Paranjpe, G Fernandez, L Brand, L Laus, R Delcayre, A Godfrey, W AF Legrand, Fatema A. McLeod, David Bilhartz, David Gittleman, Marc Adams, George Cochran, James Reiling, Richard Ruiz, Henry Karlin, Gary Owen, Rachel Nguyen, Anh-Tuan Hwang, Olivia Paranjpe, Gayatri Fernandez, Leilani Brand, Leslie Laus, Reiner Delcayre, Alain Godfrey, Wayne TI Clinical and Immunological Analysis of a Phase I Trial Evaluating MVA-BN (R)-PRO in patients with Non-metastatic Castration Resistant Prostate Cancer (CRPC) SO JOURNAL OF IMMUNOTHERAPY LA English DT Meeting Abstract C1 [Legrand, Fatema A.; Owen, Rachel; Nguyen, Anh-Tuan; Hwang, Olivia; Paranjpe, Gayatri; Fernandez, Leilani; Brand, Leslie; Laus, Reiner; Delcayre, Alain; Godfrey, Wayne] BN Immunotherapeut, Mountain View, CA USA. [McLeod, David] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Bilhartz, David] Urol Associates PC, Nashville, TN USA. [Gittleman, Marc] S Florida Med Res, Aventura, FL USA. [Adams, George] Urol Ctr Alabama PC, Birmingham, AL USA. [Cochran, James] Urol Clin N Texas, Dallas, TX USA. [Reiling, Richard] Presbyterian Hosp Ctr Canc Res, Charlotte, NC USA. [Karlin, Gary] Lawrenceville Urol, Lawrenceville, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD OCT PY 2010 VL 33 IS 8 BP 900 EP 901 PG 2 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 653XQ UT WOS:000282131800142 ER PT J AU Patil, R Clifton, GT Ciano, C Zacharia, A Mursal, M Jama, Y Krivak, T Maxwell, GL Peoples, G Ponniah, S AF Patil, Ritesh Clifton, Guy T. Ciano, Cathy Zacharia, Athena Mursal, Mohamed Jama, Yusuf Krivak, Thomas Maxwell, G. Larry Peoples, George Ponniah, Sathibalan TI Evaluation of HER2/NEU and Folate Binding Protein (FBP) Peptides in Immunotherapy for Endometrial Cancer SO JOURNAL OF IMMUNOTHERAPY LA English DT Meeting Abstract C1 [Patil, Ritesh] Windber Med Ctr, Joyce Murtha Breast Care Ctr, Windber, PA USA. [Krivak, Thomas] Univ Pittsburgh, Pittsburgh, PA USA. [Clifton, Guy T.; Peoples, George] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Clifton, Guy T.; Ciano, Cathy; Zacharia, Athena; Mursal, Mohamed; Jama, Yusuf; Peoples, George; Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Gynecol Canc Translat Res Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD OCT PY 2010 VL 33 IS 8 BP 906 EP 907 PG 2 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 653XQ UT WOS:000282131800160 ER PT J AU Sadate, S Calzzani, F Kassu, A Sharma, A Ruffin, P Brantley, C Edwards, E AF Sadate, Sandra Calzzani, Fernando, Jr. Kassu, Aschalew Sharma, Anup Ruffin, Paul Brantley, Christina Edwards, Eugene TI Recycling of surface-enhanced Raman substrates by ultraviolet cleaning SO OPTICAL ENGINEERING LA English DT Article DE surface enhanced Raman; recycling engineered substrates; UV irradiation; RDX; Rhodamine 6G ID SCATTERING; NANOPARTICLES; MOLECULES; ARRAYS; SERS AB Commercial substrates used for surface-enhanced Raman spectroscopy (SERS) are investigated for their reusability following cleaning with 254-nm UV light from a mercury lamp. SERS of Rhodamine 6G (Rh6G, a dye) and RDX (an explosive) is investigated. It is found that without UV irradiation, the substrate is usable only once, since it is not possible to dislodge the analyte either by prolonged immersion in distilled water or by ultrasonic cleaning. However, prolonged exposure to 254-nm UV followed by immersion in distilled water removes most of the analyte, making the substrate reusable for new SERS measurements. The technique of UV cleaning is demonstrated by recycling the same substrate several times and comparing SERS spectra taken after each cleaning cycle. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3491201] C1 [Sadate, Sandra; Calzzani, Fernando, Jr.; Sharma, Anup] Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. [Kassu, Aschalew] Alabama A&M Univ, Dept Technol, Normal, AL 35762 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, RDECOM, AMSRD AMR SG, Redstone Arsenal, AL 35898 USA. RP Sadate, S (reprint author), Alabama A&M Univ, Dept Phys, 4900 Meridian St, Normal, AL 35762 USA. EM anup.sharma@aamu.edu FU AMRDEC, Huntsville, Alabama; National Science Foundation FX This work is funded by AMRDEC, Huntsville, Alabama, as well as by the National Science Foundation. NR 14 TC 2 Z9 2 U1 2 U2 24 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 2010 VL 49 IS 10 AR 106501 DI 10.1117/1.3491201 PG 4 WC Optics SC Optics GA 674DC UT WOS:000283712900022 ER PT J AU Nuss, JE Dong, YX Wanner, LM Ruthel, G Wipf, P Gussio, R Vennerstrom, JL Bavari, S Burnett, JC AF Nuss, Jonathan E. Dong, Yuxiang Wanner, Laura M. Ruthel, Gordon Wipf, Peter Gussio, Rick Vennerstrom, Jonathan L. Bavari, Sina Burnett, James C. TI Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Botulinum neurotoxin; small molecule inhibitor; gas-phase pharmacophore; rational design; biothreat agent ID PROTEOLYTIC ACTIVITY; ANALOGS; BINDING; TOXIN AB Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzyme's zinc(II) metalloprotease, referred to as the light chain (LC) component, inhibits acetylcholine release into neuromuscular junctions, resulting in the disease botulism. Currently, no therapies counter BoNT poisoning postneuronal intoxication; however it is hypothesized that small molecules may be used to inhibit BoNT LC activity in the neuronal cytosol. Herein, we describe the pharmacophore-based design and chemical synthesis of potent [non-zinc(II) chelating] small molecule (nonpeptidic) inhibitors (SMNPIs) of the BoNT serotype-A LC (the most toxic of the BoNT serotype LCs). Specifically the three-dimensional superimpositions of 2-[4-(4-amidinephenoxy)-phenyl]indole-6-amidine-based SMNPI regionisomers [K(i) = 0.600 mu M (+/-0.100 mu M)], with a novel lead bis-[3-amide-5-(imidazolino) phenyl]terephthalamide (BAIPT)-based SMNPI [K(i) = 8.52 mu M (+/-0.53 mu M)], resulted in a refined four zone pharmacophore. The refined model guided the design of BAIPT-based SMNPIs possessing K(i) values = 0.572 (+/-0.041 mu M) and 0.900 mu M (0.078 mu M). C1 [Nuss, Jonathan E.; Wanner, Laura M.; Ruthel, Gordon; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Dong, Yuxiang; Vennerstrom, Jonathan L.] Univ Nebraska Med Ctr, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA. [Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Wipf, Peter] Univ Pittsburgh, Combinatorial Chem Ctr, Pittsburgh, PA 15260 USA. [Gussio, Rick] Natl Canc Inst Frederick, Dev Therapeut Program, Frederick, MD 21702 USA. [Burnett, James C.] Natl Canc Inst Frederick, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil; burnettjames@mail.nih.gov FU Defense Threat Reduction Agency [3.10084_09_RD_B]; MRMC [Y3CM 100505]; NCI, National Institutes of Health; National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX The presented research was supported by Defense Threat Reduction Agency project 3.10084_09_RD_B and also Agreement Y3CM 100505 (MRMC and NCI, National Institutes of Health) for J.C.B. Furthermore, for J.C.B.. in accordance with SAIC-Frederick. Inc., contractual requirements, this project has been funded in whole or in part with federal Funds from the National Cancer Institute, National Institutes of Health, under Contract HHSN261200800001E. NR 21 TC 12 Z9 12 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD OCT PY 2010 VL 1 IS 7 BP 301 EP 305 DI 10.1021/ml100056v PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 666FY UT WOS:000283100900001 PM 21116458 ER PT J AU Brunye, TT Ditman, T Mahoney, CR Walters, EK Taylor, HA AF Brunye, Tad T. Ditman, Tali Mahoney, Caroline R. Walters, Eliza K. Taylor, Holly A. TI You heard it here first: Readers mentally simulate described sounds SO ACTA PSYCHOLOGICA LA English DT Article DE Embodied cognition; Auditory imagery; Language ID LANGUAGE COMPREHENSION; SITUATION MODELS; NARRATIVE COMPREHENSION; SENTENCE COMPREHENSION; PICTURE-RECOGNITION; PERSPECTIVE-TAKING; SEMANTIC MEMORY; MOTOR SYSTEM; INFORMATION; IMAGERY AB The present experiments examined whether readers spontaneously simulate implied auditory elements of sentences. Participants read sentences that implicitly conveyed details that could provoke auditory imagery (e.g., The engine clattered as the truck driver warmed up his rig.), and then performed an unrelated sound categorization task during which they classified sounds as real (occurring in the world) or fake (computer generated). In Experiment 1 these two tasks were performed in sequence; in Experiment 2 they were separated into three experimental blocks to rule out the possibility that readers strategically formed auditory imagery as a result of task demands. In both studies, readers were faster to correctly categorize sounds as 'real' when the sounds had been implied by a preceding sentence. These results suggest that readers mentally simulate the implied auditory characteristics of sentences, even in the absence of tasks that promote mental simulation. Mentally simulating described events is not limited to visual and action-based modalities, further demonstrating the multimodal nature of the perceptual symbols spontaneously activated during reading. Published by Elsevier B.V. C1 [Brunye, Tad T.; Ditman, Tali; Mahoney, Caroline R.; Walters, Eliza K.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. [Ditman, Tali] Harvard Univ, Sch Med, Charlestown, MA USA. [Ditman, Tali] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbrunye@alumni.tufts.edu NR 66 TC 10 Z9 12 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-6918 J9 ACTA PSYCHOL JI Acta Psychol. PD OCT PY 2010 VL 135 IS 2 BP 209 EP 215 DI 10.1016/j.actpsy.2010.06.008 PG 7 WC Psychology, Experimental SC Psychology GA 676CD UT WOS:000283886800020 PM 20621285 ER PT J AU Aboud, S Bakari, M Francis, J Buma, D Moshiro, C Aris, EA Lyamuya, EF Janabi, M Godoy-Ramirez, K Earl, P Robb, M Marovich, M Michael, N Wahren, B Pallangyo, K Biberfeld, G Mhalu, F Sandstrom, E AF Aboud, S. Bakari, M. Francis, J. Buma, D. Moshiro, C. Aris, E. A. Lyamuya, E. F. Janabi, M. Godoy-Ramirez, K. Earl, P. Robb, M. Marovich, M. Michael, N. Wahren, B. Pallangyo, K. Biberfeld, G. Mhalu, F. Sandstrom, E. TI Broad and strong immune responses in a trial of a heterologous DNA prime MVA boost HIV vaccine among healthy Tanzanian volunteers SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Aboud, S.; Bakari, M.; Moshiro, C.; Lyamuya, E. F.; Pallangyo, K.; Mhalu, F.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Francis, J.] Natl Inst Med Res, Dar Es Salaam, Tanzania. [Buma, D.; Aris, E. A.; Janabi, M.] Muhimbili Natl Hosp, Dar Es Salaam, Tanzania. [Godoy-Ramirez, K.] Swedish Inst Infect Dis Control SMI, Solna, Sweden. [Earl, P.] NIAID, NIH, Bethesda, MD 20892 USA. [Robb, M.; Marovich, M.; Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Wahren, B.; Biberfeld, G.] Karolinska Inst, Swedish Inst Infect Dis Control, Stockholm, Sweden. [Sandstrom, E.] Karolinska Inst Sodersjukhuset, Stockholm, Sweden. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A10 EP A10 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200023 ER PT J AU Ake, J Heipertz, R Varleva, T Sanders-Buell, E Barthel, RV Taskov, H Elenkov, I Nenova, M Popivanova, N Bolen-Valenzuela, A Tjaden, J Myles, O Bautista, C Michael, N Kim, J Scott, P Tovanabutra, S AF Ake, J. Heipertz, R. Varleva, T. Sanders-Buell, E. Barthel, R. V. Taskov, H. Elenkov, I. Nenova, M. Popivanova, N. Bolen-Valenzuela, A. Tjaden, J. Myles, O. Bautista, C. Michael, N. Kim, J. Scott, P. Tovanabutra, S. TI HIV-1 Genetic Diversity in Bulgaria 2008-2009 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Ake, J.] Walter Reed Army Med Ctr, Rockville, MD USA. [Ake, J.; Heipertz, R.; Sanders-Buell, E.; Bolen-Valenzuela, A.; Myles, O.; Bautista, C.; Michael, N.; Kim, J.; Scott, P.; Tovanabutra, S.] US Mil HIV Res Program, Rockville, MD USA. [Varleva, T.] Minist Hlth, Sofia, Bulgaria. [Barthel, R. V.; Tjaden, J.] Naval Med Res Unit 3, Cairo, Egypt. [Taskov, H.] Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria. [Elenkov, I.] Hosp Infect Dis Prof Iv Kirov, Sofia, Bulgaria. [Nenova, M.] Med Univ Hosp St Marina, Varna, Bulgaria. [Popivanova, N.] Med Univ Hosp St Georg, Plovdiv, Bulgaria. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A142 EP A142 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200365 ER PT J AU Baldwin, K Cervenka, T de Souza, MS Paris, R Koehler, R Thongcharoen, P Pitisutitthum, P Nitayaphan, S Suriyanon, V Robb, M Michael, N Kim, J Kijak, G AF Baldwin, K. Cervenka, T. de Souza, M. S. Paris, R. Koehler, R. Thongcharoen, P. Pitisutitthum, P. Nitayaphan, S. Suriyanon, V. Robb, M. Michael, N. Kim, J. Kijak, G. CA TAVEG TI Genetics of Fc Gamma Receptors IIa and IIIa in vaccine trial reagents to support the study of immune correlates in RV144 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [de Souza, M. S.; Paris, R.; Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Thongcharoen, P.] Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok, Thailand. [Pitisutitthum, P.] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand. [Suriyanon, V.] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Baldwin, K.; Cervenka, T.; Koehler, R.; Robb, M.; Kijak, G.; TAVEG] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A71 EP A71 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200174 ER PT J AU Beck, Z Brown, B Wieczorek, L Matyas, G Polonis, V Peachman, K Rao, M Alving, C AF Beck, Z. Brown, B. Wieczorek, L. Matyas, G. Polonis, V. Peachman, K. Rao, M. Alving, C. TI Binding of HIV-1 to erythrocytes: effects of antibodies on trans infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Beck, Z.; Brown, B.; Wieczorek, L.; Peachman, K.] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. [Matyas, G.; Polonis, V.; Rao, M.; Alving, C.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A147 EP A147 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200378 ER PT J AU Brave, A Nilsson, C Biberfeld, G Earl, P Gudmundsdotter, L Hejdeman, B Marovich, M Michael, N Moss, B Petterson, S Polonis, V Robb, M Sandstrom, E Wahren, B AF Brave, A. Nilsson, C. Biberfeld, G. Earl, P. Gudmundsdotter, L. Hejdeman, B. Marovich, M. Michael, N. Moss, B. Petterson, S. Polonis, V. Robb, M. Sandstrom, E. Wahren, B. TI Vaccine-induced seropositivity (VISP) following immunization of healthy individuals with HIV DNA and recombinant modified vaccinia virus Ankara SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Brave, A.; Nilsson, C.; Biberfeld, G.; Gudmundsdotter, L.; Petterson, S.; Wahren, B.] Karolinska Inst, Solna, Sweden. [Brave, A.; Nilsson, C.; Biberfeld, G.; Gudmundsdotter, L.; Petterson, S.; Wahren, B.] Swedish Inst Infect Dis Control, Solna, Sweden. [Earl, P.; Moss, B.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Hejdeman, B.; Sandstrom, E.] Stockholm S Hosp, Karolinska Inst, Stockholm, Sweden. [Marovich, M.; Michael, N.; Polonis, V.; Robb, M.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A11 EP A11 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200024 ER PT J AU Cervenka, T Bladwin, K de Souza, MS Paris, R Koehler, R Thongcharoen, P Pitisutitthum, P Nitayaphan, S Suriyanon, V Robb, M Michael, N Kim, J Kijak, G AF Cervenka, T. Bladwin, K. de Souza, M. S. Paris, R. Koehler, R. Thongcharoen, P. Pitisutitthum, P. Nitayaphan, S. Suriyanon, V. Robb, M. Michael, N. Kim, J. Kijak, G. CA TAVEG TI Feasibility of high-throughput and low-cost high-resolution class I HLA typing of HIV vaccine trial cohorts in Southeast Asia SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [de Souza, M. S.; Paris, R.; Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Thongcharoen, P.] Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok, Thailand. [Pitisutitthum, P.] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand. [Suriyanon, V.] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Cervenka, T.; Bladwin, K.; Koehler, R.; Robb, M.; Kijak, G.; TAVEG] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A70 EP A71 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200173 ER PT J AU Cork, D Lembark, S Tovanabutra, S Robb, M Polonis, V Michael, N Kim, J AF Cork, D. Lembark, S. Tovanabutra, S. Robb, M. Polonis, V. Michael, N. Kim, J. TI Correlating HIV-1 gp120 Sequences with Neutralization Data Using W-curve Heuristics SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Cork, D.] IIT, MHRP HJF, Rockville, MD USA. [Lembark, S.] Workhorse Comp, Woodhaven, NY USA. [Tovanabutra, S.] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. [Polonis, V.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD USA. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A125 EP A126 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200321 ER PT J AU Gao, G Peachman, KK Wieczorek, L Polonis, V Alving, CR Rao, M Rao, VB AF Gao, G. Peachman, K. K. Wieczorek, L. Polonis, V. Alving, C. R. Rao, M. Rao, V. B. TI Bacteriophage T4 Displayed gp41 Protein as HIV-1 Vaccine Candidate SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Gao, G.; Rao, V. B.] Catholic Univ Amer, Washington, DC 20064 USA. [Peachman, K. K.; Wieczorek, L.; Polonis, V.; Alving, C. R.; Rao, M.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A86 EP A86 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200214 ER PT J AU Hallengard, D Applequist, S Nystrom, S Maltais, A Marovich, M Moss, B Earl, P Nihlmark, K Wahren, B Brave, A AF Hallengard, D. Applequist, S. Nystrom, S. Maltais, A. Marovich, M. Moss, B. Earl, P. Nihlmark, K. Wahren, B. Brave, A. TI Priming with plasmid DNA by electroporation and boosting with recombinant vaccinia virus Ankara induces polyfunctional immune responses in mice SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Hallengard, D.; Wahren, B.; Brave, A.] Karolinska Inst, Solna, Sweden. [Applequist, S.; Nystrom, S.] Karolinska Inst, Ctr Infect Med, S-10401 Stockholm, Sweden. [Marovich, M.] Walter Reed Army Inst Res, Rockville, MD USA. [Moss, B.; Earl, P.] NIAID, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A92 EP A92 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200230 ER PT J AU Kaewkungwal, J Pitisuttithum, P Nitayapan, S Stablein, D Chiu, J Benenson, M Kim, J Robb, M Michael, N Rerks-Ngarm, S AF Kaewkungwal, J. Pitisuttithum, P. Nitayapan, S. Stablein, D. Chiu, J. Benenson, M. Kim, J. Robb, M. Michael, N. Rerks-Ngarm, S. CA MOPH TAVEG TI Exploratory Age-stratified Analysis of Risk-taking Behaviors and Trial Participation Outcomes in the Thai Phase III HIV Vaccine Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Kaewkungwal, J.; Pitisuttithum, P.; MOPH TAVEG] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayapan, S.] Thai Component Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Stablein, D.] EMMES Corp, Rockville, MD USA. [Chiu, J.; Benenson, M.] US Army Med Component AFRIMS, Bangkok, Thailand. [Kim, J.; Robb, M.; Michael, N.] US Mil HIV Res Program, Rockville, MD USA. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A9 EP A9 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200020 ER PT J AU Karnasuta, C McLinden, R de Souza, M Karasavva, N Tovanabutra, S Laurence-Chenine, A Sanders-Buell, E Ochsenbauer, C Kappes, J Polonis, V Michael, N Kim, J Montefiori, DC AF Karnasuta, C. McLinden, R. de Souza, M. Karasavva, N. Tovanabutra, S. Laurence-Chenine, A. Sanders-Buell, E. Ochsenbauer, C. Kappes, J. Polonis, V. Michael, N. Kim, J. Montefiori, D. C. TI Magnitude and Breadth of the Neutralizing Antibody Response in RV144 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Karnasuta, C.; de Souza, M.] US Army Med Component, AFRIMS, Bangkok, Thailand. [McLinden, R.; Tovanabutra, S.; Laurence-Chenine, A.; Sanders-Buell, E.; Polonis, V.; Michael, N.; Kim, J.] US Mil HIV Res Program, WRAIR, Rockville, MD USA. [Ochsenbauer, C.; Kappes, J.] Univ Alabama, Birmingham, AL USA. [Montefiori, D. C.] Duke Univ, Med Ctr, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A161 EP A161 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200412 ER PT J AU Matyas, GR Wieczorek, L Peachman, KK Beck, Z Polonis, VR Rao, M Alving, CR AF Matyas, G. R. Wieczorek, L. Peachman, K. K. Beck, Z. Polonis, V. R. Rao, M. Alving, C. R. TI Differences in Lipid Binding of Neutralizing and Non-neutralizing Murine Multispecific Monoclonal Antibodies that Bind to the Same Peptide Epitopes SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Matyas, G. R.; Polonis, V. R.; Rao, M.; Alving, C. R.] Walter Reed Army Med Ctr, MHRP, Rockville, MD USA. [Wieczorek, L.; Peachman, K. K.; Beck, Z.] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A44 EP A44 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200104 ER PT J AU Oballah, PO Eller, LA Eller, MA Ouma, BJ Flach, B Taylor, A Wandege, J Souza, MD Wabwire-Mangen, F Michael, NL Robb, ML Montefiori, D Polonis, VR AF Oballah, P. O. Eller, L. A. Eller, M. A. Ouma, B. J. Flach, B. Taylor, A. Wandege, J. Souza, M. D. Wabwire-Mangen, F. Michael, N. L. Robb, M. L. Montefiori, D. Polonis, V. R. TI B cell depletion, CD4 counts and viral load impact on ADCC, binding antibodies and neutralizing antibody profiles in HIV-1 subtype A infected Ugandans SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Oballah, P. O.; Ouma, B. J.; Flach, B.; Taylor, A.; Wandege, J.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Eller, L. A.; Eller, M. A.; Michael, N. L.; Robb, M. L.; Polonis, V. R.] US Mil HIV Res Program, Rockville, MD USA. [Souza, M. D.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Wabwire-Mangen, F.] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Montefiori, D.] Duke Univ, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A52 EP A52 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200123 ER PT J AU Pitisuttithum, P Rerks-Ngarm, S Bussaratid, V Dhitavat, J Maek-a-nantawat, W Pungpak, S Suntharasamai, P Vanijanonta, S Nitayaphan, S Kaewkungwal, J Benenson, MW Chiu, J Robb, ML Gurunathan, S Francis, D Stablein, DM Kim, J AF Pitisuttithum, P. Rerks-Ngarm, S. Bussaratid, V. Dhitavat, J. Maek-a-nantawat, W. Pungpak, S. Suntharasamai, P. Vanijanonta, S. Nitayaphan, S. Kaewkungwal, J. Benenson, M. W. Chiu, J. Robb, M. L. Gurunathan, S. Francis, D. Stablein, D. M. Kim, J. TI Safety Profiles of ALVAC HIV and AIDSVAX Vaccines in the Phase III Community Based Trial in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Pitisuttithum, P.; Bussaratid, V.; Dhitavat, J.; Maek-a-nantawat, W.; Pungpak, S.; Suntharasamai, P.; Vanijanonta, S.; Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Nitayaphan, S.; Benenson, M. W.; Chiu, J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Stablein, D. M.] EMMES Corp, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A93 EP A94 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200234 ER PT J AU Rao, M Peachman, KK Li, Q Gao, G Wieczorek, L McCormack, S Polonis, VR Rao, VB Alving, CR AF Rao, M. Peachman, K. K. Li, Q. Gao, G. Wieczorek, L. McCormack, S. Polonis, V. R. Rao, V. B. Alving, C. R. TI Adjuvant-Antigen formulations and route of immunization influence the induction of binding and neutralizing antibodies to HIV-1gp41 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Peachman, K. K.; Wieczorek, L.; McCormack, S.] USMHRP, Henry M Jackson Fdn, Div Retrovirol, Rockville, MD USA. [Li, Q.; Gao, G.; Rao, V. B.] Catholic Univ Amer, Washington, DC 20064 USA. [Polonis, V. R.; Alving, C. R.] USMHRP, Div Retrovirolgy, Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A38 EP A39 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200090 ER PT J AU Rerks-Ngarm, S Premsri, N Namwat, C Pitisutthithum, P Nitayaphan, S Kaewkungwal, J Kingko, P Jirasethasiri, M Paris, R Chiu, J Kim, J Khamboonruang, C Thongchareon, P Kunasol, P AF Rerks-Ngarm, S. Premsri, N. Namwat, C. Pitisutthithum, P. Nitayaphan, S. Kaewkungwal, J. Kingko, P. Jirasethasiri, M. Paris, R. Chiu, J. Kim, J. Khamboonruang, C. Thongchareon, P. Kunasol, P. TI Community Engagement: Experience from the Thai Phase III Prime-Boost HIV Vaccine Trial, RV144 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Rerks-Ngarm, S.; Premsri, N.; Namwat, C.; Khamboonruang, C.; Thongchareon, P.; Kunasol, P.] Prime Boost HIV Vaccine Phase III Trial, Nonthaburi, Thailand. [Pitisutthithum, P.; Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, S.; Chiu, J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kingko, P.] Rayong Prov Hlth Off, Rayong, Thailand. [Jirasethasiri, M.] Chon Buri Prov Hlth Off, Chon Buri, Thailand. [Paris, R.; Kim, J.] Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A99 EP A99 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200249 ER PT J AU Rono, K Sanga, E Sekiziyivu, A Sinei, S Kroidl, I Kibuuka, H Shaffer, D Maganga, L Millard, M Khamadi, S Shikuku, K Eser, A Taylor, A Peel, S deSouza, M Michael, N Robb, ML AF Rono, K. Sanga, E. Sekiziyivu, A. Sinei, S. Kroidl, I. Kibuuka, H. Shaffer, D. Maganga, L. Millard, M. Khamadi, S. Shikuku, K. Eser, A. Taylor, A. Peel, S. deSouza, M. Michael, N. Robb, M. L. TI RV 217: The Early Capture HIV Cohort Study (ECHO): A prospective study of acute HIV infection among high risk populations SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Rono, K.; Sinei, S.; Shaffer, D.; Khamadi, S.; Shikuku, K.] Walter Reed Project Kenya, Kericho, Kenya. [Sanga, E.; Kroidl, I.; Maganga, L.; Eser, A.] Mbeya Med Res Programme, Mbeya, Tanzania. [Sekiziyivu, A.; Kibuuka, H.; Millard, M.; Taylor, A.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Peel, S.; Michael, N.] Walter Reed Army Inst Res, Silver Spring, MD USA. [deSouza, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Robb, M. L.] US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A36 EP A36 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200083 ER PT J AU Sekiziyivu, A Kibuuka, H Millard, M Watyema, C Matsiko, D Wabwire-Mangen, F Michael, N Merlin, R AF Sekiziyivu, A. Kibuuka, H. Millard, M. Watyema, C. Matsiko, D. Wabwire-Mangen, F. Michael, N. Merlin, R. TI Participant Retention of Women in African HIV prevention efficacy trials: A critical literature review SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Sekiziyivu, A.; Kibuuka, H.; Millard, M.; Watyema, C.; Matsiko, D.; Wabwire-Mangen, F.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Merlin, R.] Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A67 EP A67 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200163 ER PT J AU Tabprasit, S Vesamavibool, B Kleebmontha, A Kamonsin, V Khobchit, W Panjapornsuk, P Tongchanakarn, P Sukwit, S de Souza, MS Eamsila, C Premsri, N Rerks-Ngarm, S Paris, R Kim, J Chiu, J Nitayaphan, S AF Tabprasit, S. Vesamavibool, B. Kleebmontha, A. Kamonsin, V. Khobchit, W. Panjapornsuk, P. Tongchanakarn, P. Sukwit, S. de Souza, M. S. Eamsila, C. Premsri, N. Rerks-Ngarm, S. Paris, R. Kim, J. Chiu, J. Nitayaphan, S. CA MOPH-TAVEG Collaborators TI False HIV Seropositive among uninfected HIV vaccine recipients of phase III vaccine trial in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Tabprasit, S.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Vesamavibool, B.; Kleebmontha, A.; Kamonsin, V.; Khobchit, W.; Tongchanakarn, P.; Sukwit, S.; de Souza, M. S.; Eamsila, C.; Paris, R.; Kim, J.; Chiu, J.; MOPH-TAVEG Collaborators] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Panjapornsuk, P.] Forces Res Inst Med Sci AFRIMS, Bangkok, Thailand. [Premsri, N.; Rerks-Ngarm, S.] Minist Publ Hlth, Thai AIDS Vaccine Evaluat Grp, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A8 EP A9 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200019 ER PT J AU Wieczorek, L Brown, B Wesberry, M Ochsenbauer, C Kappes, J Lora, N Gillis, A Molnar, S Michael, N Montefiori, D Polonis, V AF Wieczorek, L. Brown, B. Wesberry, M. Ochsenbauer, C. Kappes, J. Lora, N. Gillis, A. Molnar, S. Michael, N. Montefiori, D. Polonis, V. TI HIV-1 neutralization using pooled versus individual PBMC donors as target cells SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2010 CY SEP 28-OCT 01, 2010 CL Atlanta, GA C1 [Wieczorek, L.; Brown, B.; Wesberry, M.; Lora, N.; Gillis, A.; Molnar, S.] Henry M Jackson Fdn, Rockville, MD USA. [Ochsenbauer, C.; Kappes, J.] Univ Alabama, Birmingham, AL USA. [Michael, N.; Polonis, V.] Walter Reed Army Inst Res, Rockville, MD USA. [Montefiori, D.] Duke Univ, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2010 VL 26 IS 10 BP A46 EP A46 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 665OC UT WOS:000283044200108 ER PT J AU Lieberman, HR Stavinoha, TB McGraw, SM White, A Hadden, LS Marriott, BP AF Lieberman, Harris R. Stavinoha, Trisha B. McGraw, Susan M. White, Alan Hadden, Louise S. Marriott, Bernadette P. TI Use of dietary supplements among active-duty US Army soldiers SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID UNITED-STATES; CANCER; HEALTH; MEDICATION; CHILDREN; EXERCISE; ADULTS; WOMEN; MOOD AB Background: US Army soldiers engage in strenuous activities and must maintain fitness and body weight to retain their jobs. Anecdotal reports suggest that the use of dietary supplements (DSs) by soldiers may reflect their unique occupational requirements and the complexity of their job and family responsibilities. Objective: We assessed the use of DSs by soldiers. Design: We conducted a survey of 990 randomly selected soldiers at 11 army bases globally. Data were weighted by age, sex, rank, and Special Forces status to represent the active-duty army. Results: Overall, 53% of soldiers reported the use of DSs >= 1 time/wk; 23% of soldiers used sports beverages, 6% of soldiers used sports bars or gels, and 3% of soldiers reported the use of meal-replacement beverages. Most commonly used DSs were multivitamins or multi-minerals (37.5%), protein and amino acids (18.7%), individual vitamins and minerals (17.9%), combination products (9.1%), and herbal supplements (8.3%). Many soldiers reported the use of performance-enhancement and weight-reduction products, and 22% of soldiers consumed >= 3 different DSs/wk. Logistic regression modeling indicated that older age, educational attainment, higher body mass index, and strength training were associated with DS use (P < 0.05). Reported reasons for DS use were to improve health (64%), provide more energy (31%), increase muscle strength (25%), and enhance performance (17%). Among DS users, mean monthly expenditures on DSs were $38, whereas 23% of soldiers spent >$50/mo. Conclusions: Soldiers, like civilians, use large amounts of DSs, often in combination. Soldiers use more DSs purported to enhance performance than civilians use when matched for key demographic factors. These differences may reflect the unique occupational demands and stressors of military service. Am J Clin Nutr 2010; 92:985-95. C1 [Lieberman, Harris R.; Stavinoha, Trisha B.; McGraw, Susan M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [White, Alan; Hadden, Louise S.; Marriott, Bernadette P.] ABT Associates Inc, Durham, NC USA. [Marriott, Bernadette P.] Samueli Inst, Alexandria, VA USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU US Army Medical Research and Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 28 TC 57 Z9 58 U1 3 U2 29 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD OCT PY 2010 VL 92 IS 4 BP 985 EP 995 DI 10.3945/ajcn.2010.29274 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 655FU UT WOS:000282234100040 PM 20668050 ER PT J AU Gillern, SM Chua, TC Stojadinovic, A Esquivel, J AF Gillern, Suzanne M. Chua, Terence C. Stojadinovic, Alexander Esquivel, Jesus TI KRAS Status in Patients With Colorectal Cancer Peritoneal Carcinomatosis and Its Impact on Outcome SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article DE colorectal cancer; KRAS mutations; ras gene; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis ID KIRSTEN RAS MUTATIONS; RANDOMIZED PHASE-III; K-RAS; 1ST-LINE THERAPY; ONCOLOGY-GROUP; BEVACIZUMAB; OXALIPLATIN; FLUOROURACIL; LEUCOVORIN; TUMORIGENESIS AB Background: KRAS mutated colorectal cancers (CRC) are reported to be associated with a poor response to anti-EGFR monoclonal antibody therapy and poor prognosis. We studied the rates of KRAS mutated tumors in patients with peritoneal carcinomatosis from CRC and investigated the association of KRAS status with specific clinicopathologic factors. Methods: A retrospective observational study of tumor specimens from 23 patients with peritoneal carcinomatosis from CRC was performed using standard genomic DNA sampling techniques to identify KRAS mutations. Correlation between clinicopathologic factors and KRAS mutation status was performed using the Fisher exact test or chi(2) test, as appropriate. Results: Eleven (48%) of 23 patients had KRAS mutations. There were no statistically significant correlations in patient demographics, tumor pathology, surgical evaluation, treatments, or survival outcomes for peritoneal carcinomatosis between patients with KRAS mutations or wild-type KRAS status. Conclusion: The prevalence of KRAS mutation in CRC patients with peritoneal carcinomatosis is 48% in this preliminary study and clinicopathologic factors appear to be independent of mutation status. C1 [Chua, Terence C.; Esquivel, Jesus] St Agnes Hosp, Dept Surg, Baltimore, MD 21229 USA. [Gillern, Suzanne M.; Stojadinovic, Alexander; Esquivel, Jesus] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Gillern, Suzanne M.; Stojadinovic, Alexander; Esquivel, Jesus] US Mil Canc Inst, Washington, DC USA. [Chua, Terence C.] Univ New S Wales, Dept Surg, St George Hosp, Sydney, NSW, Australia. RP Chua, TC (reprint author), St Agnes Hosp, Dept Surg, 900 Caton Ave, Baltimore, MD 21229 USA. EM Terence.chua@unsw.edu.au; jesquive@stagnes.org NR 27 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD OCT PY 2010 VL 33 IS 5 BP 456 EP 460 DI 10.1097/COC.0b013e3181b4b160 PG 5 WC Oncology SC Oncology GA 659WT UT WOS:000282598700006 PM 19952717 ER PT J AU Park, J Williamson, E Moncur, J AF Park, Jisoo Williamson, Evan Moncur, Joel TI CD117 (c-kit) and Mast Cell Tryptase Are Equivalent for Enumerating Mast Cells in "Mastocytic Enterocolitis" SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Clinical-Pathology CY OCT 27-31, 2010 CL San Francisco, CA SP Amer Soc Clin Pathol C1 [Park, Jisoo; Williamson, Evan; Moncur, Joel] Walter Reed Army Med Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2010 VL 134 IS 4 MA 65 BP 682 EP 682 PG 1 WC Pathology SC Pathology GA 652NN UT WOS:000282013900081 ER PT J AU Cash, BD AF Cash, Brooks D. TI CT Colonography: Ready for Prime Time? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Editorial Material ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; COLORECTAL-CANCER; VIRTUAL COLONOSCOPY; AMERICAN-COLLEGE; ASYMPTOMATIC ADULTS; POLYPS SMALLER; 1 CM; RISK; NEOPLASIA; POPULATION C1 [Cash, Brooks D.] Uniformed Serv Univ Hlth Sci, Gastroenterol Serv, Bethesda, MD 20889 USA. [Cash, Brooks D.] Natl Naval Med Ctr, Bethesda, MD USA. [Cash, Brooks D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cash, BD (reprint author), Uniformed Serv Univ Hlth Sci, Gastroenterol Serv, 8901 Wisconsin Ave,Bldg 9, Bethesda, MD 20889 USA. EM brooks.cash@med.navy.mil NR 42 TC 2 Z9 2 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2010 VL 105 IS 10 BP 2128 EP 2132 DI 10.1038/ajg.2010.188 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 659US UT WOS:000282593000001 PM 20927057 ER PT J AU Belur, P Betteridge, J Veerappan, G AF Belur, Pallavi Betteridge, John Veerappan, Ganesh TI A Case of Pulmonary Carcinoid Tumor in a Patient on Adalimumab for Crohn's Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 75th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 15-20, 2010 CL San Antonio, TX SP Amer Coll Gastroenterol C1 [Belur, Pallavi; Betteridge, John; Veerappan, Ganesh] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2010 VL 105 SU 1 MA 989 BP S358 EP S358 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 663VG UT WOS:000282917701177 ER PT J AU Betteridge, J Maydonovitch, C Veerappan, G AF Betteridge, John Maydonovitch, Corinne Veerappan, Ganesh TI Demographic Differences Among Patients with Inflammatory Bowel Disease in the U.S Military Health System SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 75th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 15-20, 2010 CL San Antonio, TX SP Amer Coll Gastroenterol C1 [Betteridge, John; Maydonovitch, Corinne; Veerappan, Ganesh] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2010 VL 105 SU 1 MA 1267 BP S465 EP S466 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 663VG UT WOS:000282917701457 ER PT J AU Damiano, M Young, P Lake, J AF Damiano, Mark Young, Patrick Lake, Jason TI McBurney's Point Meets Occam's Razor: A Not So Simple Case of Appendicitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 75th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 15-20, 2010 CL San Antonio, TX SP Amer Coll Gastroenterol C1 [Damiano, Mark; Young, Patrick] Natl Naval Med Ctr, Bethesda, MD USA. [Lake, Jason] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2010 VL 105 SU 1 MA 933 BP S338 EP S338 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 663VG UT WOS:000282917701122 ER PT J AU Hjelkrem, M Stengel, J Liu, M Jones, D AF Hjelkrem, Michael Stengel, Joel Liu, Mark Jones, David TI A Randomized Blinded Prospective Trial Comparing PEG 3350 (MiraLAX (R)) with Bisacodyl Pretreatment versus PEG 3350 (MiraLAX (R)) with Lubiprostone Pretreatment versus PEG 3350 (MiraLAX (R)) without Pretreatment versus PEG 3350 (Golytely (R)) for Bowel Cleansing Prior to Colonoscopy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 75th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 15-20, 2010 CL San Antonio, TX SP Amer Coll Gastroenterol C1 [Hjelkrem, Michael; Stengel, Joel; Liu, Mark; Jones, David] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2010 VL 105 SU 1 MA 375 BP S138 EP S138 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 663VG UT WOS:000282917700370 ER PT J AU Forman, HP Beauchamp, NJ Kazerooni, EA Larson, DB Javitt, MC Norbash, A AF Forman, Howard P. Beauchamp, Norman J., Jr. Kazerooni, Ella A. Larson, David B. Javitt, Marcia C. Norbash, Alexander TI Masters of Radiology Panel Discussion: Who Is Accountable for the Appropriateness of Studies-The Radiologist, the Referring Physician, or Both? SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE appropriateness criteria; clinicians; decision support; relationships C1 [Forman, Howard P.] Yale Univ, Dept Diagnost Radiol, New Haven, CT 06510 USA. [Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Kazerooni, Ella A.] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA. [Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. RP Forman, HP (reprint author), Yale Univ, Dept Diagnost Radiol, New Haven, CT 06510 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563 NR 3 TC 3 Z9 3 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2010 VL 195 IS 4 BP 968 EP 973 DI 10.2214/AJR.10.4997 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 652TU UT WOS:000282033600026 PM 20858826 ER PT J AU Hsiao, M Owens, BD Burks, R Sturdivant, RX Cameron, KL AF Hsiao, Mark Owens, Brett D. Burks, Robert Sturdivant, Rodney X. Cameron, Kenneth L. TI Incidence of Acute Traumatic Patellar Dislocation Among Active-Duty United States Military Service Members SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE patella; dislocation; epidemiology; risk factors ID ANTERIOR CRUCIATE LIGAMENT; RISK-FACTORS; CONSERVATIVE TREATMENT; NATURAL-HISTORY; PUBLIC-HEALTH; INJURY; ARMY; OSTEOARTHRITIS; REDISLOCATION; EPIDEMIOLOGY AB Background: Although some studies have reported an increased incidence of patellar dislocations within active populations, few studies have reported incidence rates and examined risk factors for this injury. Purpose: To examine the incidence of patellar dislocation injuries and the influence of demographic and occupational risk factors associated with injury among active-duty United States (US) service members between 1998 and 2007. Study Design: Cohort study; Level of evidence, 3. Methods: Using the Defense Medical Surveillance System, a search was performed for International Classification of Disease, 9th Revision (ICD-9) code 836.3 among all US service members on active duty during the study period. Multivariable Poisson regression analysis was used to estimate the rate of patellar dislocation per 1000 person-years at risk to injury. Incidence rates (IRs) and incidence rate ratios (IRRs) for patellar dislocation along with 95% confidence intervals (CIs) were estimated by gender, age, race, branch of military service, and rank while controlling for the other variables in the model. Results: There were a total of 9299 individuals with documented patellar dislocation injuries among a population at risk of 13 443 448 person-years. The IR was 0.69 per 1000 person-years at risk. Women were 61% more likely (IRR, 1.61; 95% CI, 1.53-1.69) to sustain a patellar dislocation injury than men. Rates were highest in the youngest age group and decreased with increasing age. Service members aged <20 years were 84% more likely (IRR, 1.84; 95% CI, 1.61-2.10) to sustain a patellar dislocation injury as service members aged >= 40 years. Differences were also noted by race, service, and rank. Conclusion: The incidence of patellar dislocation injuries among US service members was an order of magnitude greater than that previously reported in civilian population studies. Gender, age, race, rank, and branch of military service are important risk factors related to the incidence of patellar dislocation injuries in this population. C1 [Hsiao, Mark; Owens, Brett D.; Cameron, Kenneth L.] Keller Army Hosp, Dept Orthoped Surg, West Point, NY 10996 USA. [Burks, Robert] USN, Postgrad Sch, Dept Operat Res, Monterey, CA USA. [Sturdivant, Rodney X.] US Mil Acad, Dept Math, West Point, NY 10996 USA. RP Cameron, KL (reprint author), Keller Army Hosp, Dept Orthopaed Res, 900 Washington Ave, West Point, NY 10996 USA. EM kenneth.cameron@amedd.army.mil RI Burks, Robert/J-2481-2015; OI Burks, Robert/0000-0001-6443-6653; Cameron, Kenneth/0000-0002-6276-4482 NR 37 TC 32 Z9 37 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD OCT PY 2010 VL 38 IS 10 BP 1997 EP 2004 DI 10.1177/0363546510371423 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 656VQ UT WOS:000282369600005 PM 20616375 ER PT J AU Sheppard, FR Keiser, P Craft, DW Gage, F Robson, M Brown, TS Petersen, K Sincock, S Kasper, M Hawksworth, J Tadaki, D Davis, TA Stojadinovic, A Elster, E AF Sheppard, Forest R. Keiser, Paul Craft, David W. Gage, Fred Robson, Martin Brown, Trevor S. Petersen, Kyle Sincock, Stephanie Kasper, Matt Hawksworth, Jason Tadaki, Doug Davis, Thomas A. Stojadinovic, Alexander Elster, Eric TI The majority of US combat casualty soft-tissue wounds are not infected or colonized upon arrival or during treatment at a continental US military medical facility SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Combat extremity wounds; Combat soft-tissue wounds; Vacuum-assisted wound closure; Device; Microorganisms ID BIOPSY; SWAB; BACTERIA; IRAQ AB BACKGROUND: The microbiology of war wounds has changed as medicine and warfare have evolved. This study was designed to determine the microbial flora and bacterial quantification of present-day war wounds in US troops from Iraq and Afghanistan upon arrival at the National Naval Medical Center (NNMC). METHODS: Patients with extremity combat wounds treated with a vacuum-assisted wound closure device were enrolled in study. Wounds were biopsied every 48 to 72 hours with quantitative microbiology performed on all biopsies. RESULTS: Two hundred forty-two wound biopsies from 34 patients; 167 (69%) showed no growth, and 75 (31%) showed positive growth. The incidence of any bacterial isolation from biopsies weekly from the time of injury was 28% (first), 31% (second), and 37% (>= third). Acinetobacter baumannii was the most prevalent isolate. CONCLUSIONS: Most soft-tissue wounds from Iraq and Afghanistan do not have significant bacterial burden upon arrival to and during initial treatment at NNMC. Improved evaluation of combat wound microbiology at all levels of care is warranted to determine shifts in microbiology and to impact care practices. Published by Elsevier Inc. C1 [Sheppard, Forest R.; Gage, Fred; Elster, Eric] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Sheppard, Forest R.; Gage, Fred; Brown, Trevor S.; Hawksworth, Jason; Tadaki, Doug; Davis, Thomas A.; Elster, Eric] Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. [Sheppard, Forest R.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Keiser, Paul; Craft, David W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Robson, Martin] Univ S Florida, Dept Surg, Tampa, FL 33620 USA. [Sincock, Stephanie; Kasper, Matt] Natl Naval Med Ctr, Dept Microbiol, Bethesda, MD USA. [Hawksworth, Jason; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Sheppard, FR (reprint author), Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. EM Forest.Sheppard@med.navy.mil RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015 OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X FU US Navy Bureau of Medicine and Surgery [PE 0604771N]; Office of Naval Research [604771N.0933.001.A0604] FX Supported in part by the US Navy Bureau of Medicine and Surgery under the Medical Development Program (PE 0604771N) and Office of Naval Research work unit number: 604771N.0933.001.A0604. This study was approved by the National Naval Medical Center Institutional Review Board in compliance with all Federal regulations governing the protection of human subjects. NR 14 TC 30 Z9 31 U1 2 U2 5 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD OCT PY 2010 VL 200 IS 4 BP 489 EP 495 DI 10.1016/j.amjsurg.2010.03.001 PG 7 WC Surgery SC Surgery GA 666JB UT WOS:000283109800010 PM 20887842 ER PT J AU Potts, JA Thomas, SJ Srikiatkhachorn, A Supradish, PO Li, WJ Nisalak, A Nimmannitya, S Endy, TP Libraty, DH Gibbons, RV Green, S Rothman, AL Kalayanarooj, S AF Potts, James A. Thomas, Stephen J. Srikiatkhachorn, Anon Supradish, Pra-on Li, Wenjun Nisalak, Ananda Nimmannitya, Suchitra Endy, Timothy P. Libraty, Daniel H. Gibbons, Robert V. Green, Sharone Rothman, Alan L. Kalayanarooj, Siripen TI Classification of Dengue Illness Based on Readily Available Laboratory Data SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID JAPANESE ENCEPHALITIS; HEMORRHAGIC-FEVER; CASE DEFINITIONS; SEVERITY; NEED; INFECTIONS; NICARAGUA; FEATURES; CHILDREN; SYSTEM AB The aim of this study was to examine retrospective dengue-illness classification using only clinical laboratory data, without relying on X-ray, ultrasound, or percent hemoconcentration. We analyzed data from a study of children who presented with acute febrile illness to two hospitals in Thailand. Multivariable logistic regression models were used to distinguish: (1) dengue hemorrhagic fever (DHF) versus dengue fever (DF), (2) DHF versus DF + other febrile illness (OFI), (3) dengue versus OFI, and (4) severe dengue versus non-severe dengue + OFI. Data from the second hospital served as a validation set. There were 1,227 patients in the analysis. The sensitivity of the models ranged from 89.2% (dengue versus OF!) to 79.6% (DHF versus DF). The models showed high sensitivity in the validation dataset. These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions. C1 [Potts, James A.; Srikiatkhachorn, Anon; Li, Wenjun; Libraty, Daniel H.; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Potts, James A.; Srikiatkhachorn, Anon; Li, Wenjun; Libraty, Daniel H.; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA. [Thomas, Stephen J.; Nisalak, Ananda; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. [Supradish, Pra-on; Nimmannitya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Endy, Timothy P.] SUNY Upstate Med Univ, Dept Med, Syracuse, NY USA. RP Rothman, AL (reprint author), 55 Lake Ave N, Worcester, MA 01655 USA. EM James.Potts@umassmed.edu; stephen.thomas@afrims.org; Anon.Srikiatkhachorn@umassmed.edu; praonsu@yahoo.com; Wenjun.Li@umassmed.edu; anandan@afrims.org; sujitran@health.moph.go.th; endyt@upstate.edu; Daniel.Libraty@umassmed.edu; robert.gibbons@afrims.org; Sharone.Green@umassmed.edu; Alan.Rothman@umassmed.edu; sirip@health.moph.go.th RI Li, Wenjun/F-5634-2015 OI Li, Wenjun/0000-0001-5335-7386 FU National Institutes of Health [NIH-P01A134533]; Centers for Disease Control and Prevention Office of the Director [1R36CK00123-01]; Military Infectious Disease Research Program FX This work was supported by National Institutes of Health Grant NIH-P01A134533, Centers for Disease Control and Prevention Office of the Director Grant 1R36CK00123-01, and the Military Infectious Disease Research Program. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the view of the US Government. The authors have no conflicting financial interests. NR 20 TC 12 Z9 12 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2010 VL 83 IS 4 BP 781 EP 788 DI 10.4269/ajtmh.2010.10-0135 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 663DF UT WOS:000282862500011 PM 20889865 ER PT J AU Wu, J Cropek, DM West, AC Banta, S AF Wu, Jun Cropek, Donald M. West, Alan C. Banta, Scott TI Development of a Troponin I Biosensor Using a Peptide Obtained through Phage Display SO ANALYTICAL CHEMISTRY LA English DT Article ID QUARTZ-CRYSTAL MICROBALANCE; SURFACE-PLASMON RESONANCE; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; TYROSINE-PHOSPHORYLATED PEPTIDES; ACUTE MYOCARDIAL-INFARCTION; FRAGMENT VARIABLE ANTIBODY; CARDIAC TROPONIN; IMPEDIMETRIC IMMUNOSENSOR; BIOCHEMICAL MARKERS; SENSOR AB A small synthetic peptide with nanomolar affinity for cardiac troponin I (TnI) previously identified from a polyvalent phage displayed library, has been immobilized on a gold surface for TnI detection. The binding affinity of gold-immobilized peptides for TnI was studied and compared with that of phage-immobilized peptides. Quartz crystal microbalance (QCM), cyclic voltammetry, and electrochemical impedance spectroscopy (EIS) were used to monitor both the immobilization and target binding processes. All three techniques show that the binding is specific for TnI as compared to a streptavidin (SA) control. The response curves obtained at TnI concentrations ranging from 0 to 10 mu g/mL, using both QCM and EIS, were also compared. For the EIS measurements, the sensitivity was 0.30 +/- 0.030 normalized impedance/(mu g/mL) and the limit of detection (LOD) was 0.34 mu g/mL. Using the QCM, a sensitivity of 18 +/- 1 Hz/(mu g/mL) was obtained, corresponding to an LOD of 0.11 mu g/mL. Although the QCM demonstrated a lower LOD as compared to EIS, the latter technique exhibited a larger linear dynamic range than QCM. In a relevant tissue culture milieu, Minimum Essential Media (MEM), the sensitivity of the EIS measurement was greater than that obtained in a phosphate buffer system (PBS). The kinetics of target binding using QCM were analyzed by two independent methods, and the dissociation constants (K(D) = 66 +/- 4 nM and 17 +/- 8 nM) were an order of magnitude higher than that calculated for the polyvalent phage particles (K(D) = 2.5 +/- 0.1 nM). Even though the affinity of the immobilized peptides for Till was somewhat reduced, overall, these results demonstrate that peptides obtained from the biopanning of phage display libraries can be readily used as sensing probes in biosensor development. C1 [Wu, Jun; West, Alan C.; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Wu, Jun; Cropek, Donald M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. EM sbanta@columbia.edu FU U.S. Army Engineering Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) FX This research was supported by U.S. Army Corps of Engineers Applied Research program with funding from the U.S. Army Engineering Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL). NR 72 TC 37 Z9 37 U1 10 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD OCT 1 PY 2010 VL 82 IS 19 BP 8235 EP 8243 DI 10.1021/ac101657h PG 9 WC Chemistry, Analytical SC Chemistry GA 655NT UT WOS:000282257400050 PM 20831206 ER PT J AU Mark, AL Sun, ZL Warren, DS Lonze, BE Knabel, MK Williams, GMM Locke, JE Montgomery, RA Cameron, AM AF Mark, Anthony L. Sun, Zhaoli Warren, Daniel S. Lonze, Bonnie E. Knabel, Matthew K. Williams, George M. Melville Locke, Jayme E. Montgomery, Robert A. Cameron, Andrew M. TI Stem Cell Mobilization Is Life Saving in an Animal Model of Acute Liver Failure SO ANNALS OF SURGERY LA English DT Article ID ACUTE MYOCARDIAL-INFARCTION; FULMINANT HEPATIC-FAILURE; G-CSF; BONE-MARROW; PROGENITOR CELLS; THERAPY; TRANSPLANTATION; CIRRHOSIS; SAFETY AB Objective: No therapy except liver transplantation currently exists for patients with acute liver failure (ALF). The aim of this study was to determine whether pharmacologic mobilization of endogenous hematopoietic stem cells (HSCs) can aid in liver repair and improve survival in an animal model of ALF. Methods: Rodents were treated with a single near-lethal intraperitoneal injection of carbon tetrachloride (CCl(4)). After 12 hours, animals were randomized to receive plerixafor and granulocyte colony-stimulating factor (G-CSF), agents known to mobilize marrow-derived stem cells, or saline vehicle injection. Mice were observed for survival, and serial assessment of liver injury by serum transaminase measurements, and histologic analysis was performed. Results: In our ALF model, 7-day survival after injection of CCl(4) was 25%. Administration of plerixafor and G-CSF following CCl(4) resulted in 87% survival (n = 8, P < 0.05). On serial histopathologic analysis, animals treated with plerixafor and G-CSF demonstrated less hepatic injury compared with control animals. Evaluation of peripheral blood demonstrated an increase in circulating HSCs in response to plerixafor and G-CSF, and immunostaining suggested the infiltration of HSCs into the hepatic parenchyma after stem cell mobilization. Conclusions: Our results suggest a possible new treatment strategy for patients with ALF, a group for whom either liver transplantation or death is frequently the outcome. Pharmacologic agents that mobilize HSCs may lead to an infiltration of the injured liver with cells that may participate in or expedite liver regeneration. This therapy has the potential to avert liver transplantation in some patients with ALF and may be of benefit in a wide variety of medical and surgical patients with liver injury. C1 [Sun, Zhaoli; Warren, Daniel S.; Lonze, Bonnie E.; Williams, George M. Melville; Locke, Jayme E.; Montgomery, Robert A.; Cameron, Andrew M.] Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplantat, Baltimore, MD 21205 USA. [Mark, Anthony L.] Walter Reed Army Med Ctr, Dept Surg, Bethesda, MD USA. [Knabel, Matthew K.] Johns Hopkins Univ, Sch Med, Dept Human Genet, Baltimore, MD 21205 USA. RP Cameron, AM (reprint author), Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplantat, 720 Rutland Ave,Ross 765, Baltimore, MD 21205 USA. EM acamero5@jhmi.edu OI Lonze, Bonnie/0000-0002-0973-1657 FU American Surgical Association Foundation; Genzyme Corporation, Cambridge, MA FX Supported by an American Surgical Association Foundation Fellowship (to A.M.C.) and by a Research grant from Genzyme Corporation, Cambridge, MA. NR 22 TC 33 Z9 36 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD OCT PY 2010 VL 252 IS 4 BP 591 EP 595 DI 10.1097/SLA.0b013e3181f4e479 PG 5 WC Surgery SC Surgery GA 656VO UT WOS:000282369400003 PM 20881764 ER PT J AU Heine, HS Bassett, J Miller, L Purcell, BK Byrne, WR AF Heine, Henry S. Bassett, Jennifer Miller, Lynda Purcell, Bret K. Byrne, W. Russell TI Efficacy of Daptomycin against Bacillus anthracis in a Murine Model of Anthrax Spore Inhalation SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID STAPHYLOCOCCUS-AUREUS; BACTERICIDAL ACTIVITY; RESISTANT; DOXYCYCLINE; STERNE AB Daptomycin demonstrated in vitro (MIC(90), 4 mu g/ml) and in vivo activities against Bacillus anthracis. Twice-daily treatment with a dose of 50 mg/kg of body weight was begun 24 h after challenge and continued for 14 or 21 days; results were compared to those for controls treated with phosphate-buffered saline or ciprofloxacin. Day 43 survival rates were 6/10 mice for the 14-day and 9/10 mice for the 21-day treatment groups, compared to survival with ciprofloxacin: 8/10 and 9/10 mice, respectively. Culture results from tissues removed at the termination of the experiment were negative. C1 [Heine, Henry S.; Bassett, Jennifer; Miller, Lynda; Purcell, Bret K.; Byrne, W. Russell] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. RP Heine, HS (reprint author), Ordway Res Inst, Ctr Biodef & Emerging Infect, 150 New Scotland Ave, Albany, NY 12208 USA. EM hheine@ordwayresearch.org FU Defense Threat Reduction Agency [02-4-2C-013] FX The research described herein was sponsored by the Defense Threat Reduction Agency (project no. 02-4-2C-013). NR 25 TC 9 Z9 9 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2010 VL 54 IS 10 BP 4471 EP 4473 DI 10.1128/AAC.00210-10 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 651EI UT WOS:000281907200057 PM 20643899 ER PT J AU Indest, KJ Jung, CM Chen, HP Hancock, D Florizone, C Eltis, LD Crocker, FH AF Indest, Karl J. Jung, Carina M. Chen, Hao-Ping Hancock, Dawn Florizone, Christine Eltis, Lindsay D. Crocker, Fiona H. TI Functional Characterization of pGKT2, a 182-Kilobase Plasmid Containing the xplAB Genes, Which Are Involved in the Degradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine by Gordonia sp. Strain KTR9 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID RDX DEGRADATION; CORYNEBACTERIUM-GLUTAMICUM; ANAEROBIC BIODEGRADATION; RHODOCOCCUS-ERYTHROPOLIS; MYCOBACTERIUM-SMEGMATIS; CYTOCHROME-P450 SYSTEM; ELECTRON-DONORS; BACTERIA; TRANSFORMATION; EXPLOSIVES AB Several microorganisms have been isolated that can transform hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a cyclic nitramine explosive. To better characterize the microbial genes that facilitate this transformation, we sequenced and annotated a 182-kb plasmid, pGKT2, from the RDX-degrading strain Gordonia sp. KTR9. This plasmid carries xplA, encoding a protein sharing up to 99% amino acid sequence identity with characterized RDX-degrading cytochromes P450. Other genes that cluster with xplA are predicted to encode a glutamine synthase-XplB fusion protein, a second cytochrome P450, Cyp151C, and XplR, a GntR-type regulator. Rhodococcus jostii RHA1 expressing xplA from KTR9 degraded RDX but did not utilize RDX as a nitrogen source. Moreover, an Escherichia coli strain producing XplA degraded RDX but a strain producing Cyp151C did not. KTR9 strains cured of pGKT2 did not transform RDX. Physiological studies examining the effects of exogenous nitrogen sources on RDX degradation in strain KTR9 revealed that ammonium, nitrite, and nitrate each inhibited RDX degradation by up to 79%. Quantitative real-time PCR analysis of glnA-xplB, xplA, and xplR showed that transcript levels were 3.7-fold higher during growth on RDX than during growth on ammonium and that this upregulation was repressed in the presence of various inorganic nitrogen sources. Overall, the results indicate that RDX degradation by KTR9 is integrated with central nitrogen metabolism and that the uptake of RDX by bacterial cells does not require a dedicated transporter. C1 [Indest, Karl J.; Jung, Carina M.; Hancock, Dawn; Crocker, Fiona H.] USA, CEERD EP P, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Chen, Hao-Ping; Florizone, Christine; Eltis, Lindsay D.] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada. RP Indest, KJ (reprint author), USA, CEERD EP P, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Karl.J.Indest@usace.army.mil; leltis@interchange.ubc.ca RI Eltis, Lindsay/J-8272-2015 OI Eltis, Lindsay/0000-0002-6774-8158 FU Strategic Environmental Research and Development Program [ER-1609]; U.S. Army Corps of Engineers; Genome BC; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID) [HHSN266200400042C] FX This research was funded in part through grants from the Strategic Environmental Research and Development Program (project ER-1609), the U.S. Army Corps of Engineers Environmental Quality Research Program, and Genome BC. The use of RAST was supported in part by National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID), under contract HHSN266200400042C. NR 56 TC 25 Z9 25 U1 0 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 2010 VL 76 IS 19 BP 6329 EP 6337 DI 10.1128/AEM.01217-10 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 653ZA UT WOS:000282136700001 PM 20709853 ER PT J AU Tyynela, J Zubko, E Muinonen, K Videen, G AF Tyynela, Jani Zubko, Evgenij Muinonen, Karri Videen, Gorden TI Interpretation of single-particle negative polarization at intermediate scattering angles SO APPLIED OPTICS LA English DT Article ID DISCRETE-DIPOLE APPROXIMATION; INTERNAL ELECTRIC-FIELDS; LIGHT-SCATTERING; IRREGULAR PARTICLES; AEROSOL-PARTICLES; WAVELENGTH; DISTRIBUTIONS; SIMULATIONS; SYMMETRY; MATRICES AB We study the interrelation of the internal field of irregular particles to the far-field scattering characteristics by modifying the internal field of dipole groups. In this paper, we concentrate on the longitudinal component, i.e., the internal-field component parallel to the incident wave vector. We use the discrete-dipole approximation to determine the internal field and switch off the longitudinal component from the dipoles that have the highest energy density above a preset cutoff value. We conclude that only a relatively small number of core dipoles, about 5% of all dipoles, contribute to the negative linear polarization at intermediate scattering angles. These core dipole groups are located at the forward part of the particles. The number of core dipoles in the group becomes greater as particle asphericity increases. We find that the interference between the scattered waves from the core dipole groups, which was studied previously for spherical particles, is preserved to a large extent for nonspherical particles. (C) 2010 Optical Society of America C1 [Tyynela, Jani; Zubko, Evgenij; Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Zubko, Evgenij] Astron Inst Kharkov Natl Univ, UA-61022 Kharkov, Ukraine. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Tyynela, J (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland. EM jktyynel@mappi.helsinki.fi RI Tyynela, Jani/H-4761-2011 FU Academy of Finland [1127461] FX This study was partially supported by the Academy of Finland (contract 1127461). NR 30 TC 14 Z9 14 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 1 PY 2010 VL 49 IS 28 BP 5284 EP 5296 DI 10.1364/AO.49.005284 PG 13 WC Optics SC Optics GA 657WO UT WOS:000282449800013 PM 20885464 ER PT J AU Bright, FV Holthoff, EL AF Bright, Frank V. Holthoff, Ellen L. TI Dynamics Within Site Selectively Templated and Tagged Xerogel Sensor Platforms SO APPLIED SPECTROSCOPY LA English DT Article DE Fluorescence; Anisotropy decays; Sensors; Molecular imprinting; Photophysics ID LIFETIME DISTRIBUTIONS; SOL-GELS; FLUORESCENCE ANISOTROPY; FLUOROMETRY; PHOTOPHYSICS AB In a nitrobenzo-2-oxa-1,3-diazole (NBD) -based, 9-anthrol-responsive site selectively templated and tagged xerogel (SSTTX) sensor platform, there are two reporter molecule site types (responsive and non-responsive) that are responsible for the observed fluorescence signals. These NBD sites function independently. Site I alone binds the target analyte and yields an analyte-dependent signal. This signal arises from analyte binding decreasing the photo-induced electron transfer (PET) efficiency between a strategically placed amine residue and the excited NBD reporter molecule within the template site. Site 2 does not respond to analyte, it is not fully formed, and it manifests itself as a background signal. In an n-octyl residue-free SSTTX, the local microviscosity sensed by the site I NBD reporter molecules in the absence and presence of target analyte is similar to 260 cP and similar to 540 cP, respectively. These local microviscosity values are substantially greater in comparison to free NBD dissolved in THF (eta = 0.46 cP at 298 K, phi similar to 25 ps). As the SSTTX n-octyl content is increased, the local microviscosity sensed by the site 1 NBD reporter molecules in the absence and presence of target analyte is similar to 360 cP and similar to 760 cP, respectively. This behavior is consistent with the n-octyl chains crowding the cybotactic region surrounding the site 1 NBD reporter molecules. This n-octyl-induced site I "crowding" is also associated with improved analyte binding to site l and better overall SSTTX analytical performance. C1 [Bright, Frank V.] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA. [Holthoff, Ellen L.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Bright, FV (reprint author), SUNY Buffalo, Dept Chem, Nat Sci Complex, Buffalo, NY 14260 USA. EM chefvb@buffalo.edu OI Bright, Frank/0000-0002-1500-5969 FU National Science Foundation [CHE-0848171] FX This research is based in part upon work supported by the National Science Foundation under Grant Number CHE-0848171. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. NR 20 TC 1 Z9 1 U1 0 U2 6 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD OCT PY 2010 VL 64 IS 10 BP 1073 EP 1077 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 663AN UT WOS:000282855500001 PM 20925975 ER PT J AU Wong, L AF Wong, Leonard TI Until the Last Man Comes Home: POWs, MIAs, and the Unending Vietnam War SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Wong, Leonard] USA, War Coll, Carlisle, PA USA. RP Wong, L (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2010 VL 36 IS 5 BP 930 EP 931 DI 10.1177/0095327X10379721 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA 669PQ UT WOS:000283363100010 ER PT J AU Griffith, J AF Griffith, James TI The Greatest Generation Comes Home: The Veteran in American Society SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Griffith, James] US Army Natl Guard, Damascus, MD USA. RP Griffith, J (reprint author), US Army Natl Guard, Damascus, MD USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2010 VL 36 IS 5 BP 933 EP 936 DI 10.1177/0095327X10379726 PG 5 WC Political Science; Sociology SC Government & Law; Sociology GA 669PQ UT WOS:000283363100012 ER PT J AU Trego, L Wilson, C Steele, N AF Trego, Lori Wilson, Candy Steele, Nancy TI A Call to Action for Evidence-Based Military Women's Health Care: Developing a Women's Health Research Agenda That Addresses Sex and Gender in Health and Illness SO BIOLOGICAL RESEARCH FOR NURSING LA English DT Article DE women's health; military health care; research ID PRIORITIES; DEPLOYMENT; VETERANS; FREEDOM; WAR AB Women in the Army, Navy, Air Force, and Marines are serving in complex occupational specialties that sustain national policy and ensure combat effectiveness of our forces. Their roles have evolved from supportive roles during early conflicts to active roles in combat support and counterinsurgency operations today. Although women have received military health care over the past three decades, sex- and gender-specific care has been limited to reproductive needs and has rarely addressed military-specific health risks and outcomes. The complexity of military jobs and increased deployments to combat operations has led to increased occupational and health risks for women. As differences have been noted between men and women's deployment-related health outcomes, it is incumbent on the Military Health Care System (MHS) to create an evidence base that addresses sex and gender differences in the health of its service members. A working group of military women's health advanced practice nurses (APN) and research experts proposes to address this gap in knowledge and practices through sex- and gender-specific research. A sex-and gender-based research agenda for military women's health will be a valuable instrument to those who are dedicated to the health of this population, including members of the Army, Navy, and Air Force military nursing community. Using the knowledge that the research agenda generates, military health care providers can develop clinical practice guidelines, influence policy, and participate in program development to improve the health of servicewomen. Shaping a sex- and gender-specific military women's health research agenda will create the foundation for future evidence-based care. C1 [Trego, Lori] US Army Nurse Corps, Nursing Res Serv, Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wilson, Candy] US AF Nurse Corps, CSPG SGVUS 59, Lackland AFB, TX USA. [Steele, Nancy] US Army Nurse Corps, European Reg Med Command, Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Trego, L (reprint author), US Army Nurse Corps, Nursing Res Serv, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Lori.trego@us.army.mil RI lyp, maggie/G-1471-2011 NR 36 TC 8 Z9 8 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1099-8004 EI 1552-4175 J9 BIOL RES NURS JI Biol. Res. Nurs. PD OCT PY 2010 VL 12 IS 2 BP 171 EP 177 DI 10.1177/1099800410375299 PG 7 WC Nursing SC Nursing GA 649TH UT WOS:000281796300008 PM 20798161 ER PT J AU Rastogi, A Luo, ZQ Wu, ZJ Ho, PS Bowman, PD Stavchansky, S AF Rastogi, Ashish Luo, Zhiquan Wu, Zhuojie Ho, Paul S. Bowman, Phillip D. Stavchansky, Salomon TI Development and characterization of a scalable microperforated device capable of long-term zero order drug release SO BIOMEDICAL MICRODEVICES LA English DT Article DE Drug delivery device; Microholes; Polymer free; Zero order; Long term release ID PAIN MANAGEMENT; DELIVERY; IMPLANTS; NORPLANT AB A drug delivery system that consists of microperforated polyimide microtubes was developed and characterized. Two groups of polyimide tubes were used. One set consisted of microtubes (I.D. = 125 mu m) with 32.9 +/- 1.7 mu m size holes. The second set consisted of larger tubes (I.D. = 1000 mu m) with 362-542 mu m holes. The number of holes was varied between 1 and 3. The small tubes were loaded with crystal violet (CV) and ethinyl estradiol (EE) and the drug release studies were performed in 0.01 M phosphate buffered saline (PBS) (pH 7.1-7.4) at 37.0 +/- 1.0A degrees C for upto 4 weeks. The large tubes were loaded with CV and the drug release was studied in vitro in PBS and also ex vivo in rabbit's vitreous humor. Linear release rates with R(2) > 0.9900 were obtained for all groups with CV and EE. Release rates of 7.8 A +/- 2.5, 16.2 A +/- 5.5, and 22.5 A +/- 6.0 ng/day for CV and 30.1 A +/- 5.8 ng/day for EE were obtained for small tubes. For large tubes, a release rate of 10.8 A +/- 4.1, 15.8 A +/- 4.8 and 22.1 A +/- 6.7 mu g/day was observed in vitro in PBS and a release rate of 5.8 A +/- 1.8 mu g/day was observed ex vivo in vitreous humor. C1 [Rastogi, Ashish; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Luo, Zhiquan; Wu, Zhuojie; Ho, Paul S.] Univ Texas Austin, Microelect Res Ctr, MER, MRC, Austin, TX 78758 USA. [Rastogi, Ashish; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Stavchansky, S (reprint author), Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. EM stavchansky@mail.utexas.edu RI Wu, Zhuojie/K-7484-2012 NR 29 TC 5 Z9 5 U1 1 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-2176 J9 BIOMED MICRODEVICES JI Biomed. Microdevices PD OCT PY 2010 VL 12 IS 5 BP 915 EP 921 DI 10.1007/s10544-010-9446-x PG 7 WC Engineering, Biomedical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA 635HY UT WOS:000280647400017 PM 20585863 ER PT J AU Hilmas, CJ Scherer, JW Williams, PT AF Hilmas, Corey J. Scherer, John W. Williams, Patrick T. TI A nerve clamp electrode design for indirect stimulation of skeletal muscle SO BIOTECHNIQUES LA English DT Article DE stimulating electrode; botulinum neurotoxin; skeletal muscle; paralysis ID BOTULINUM TOXIN AB A nerve clamp electrode was developed to indirectly stimulate skeletal muscle innervated by alpha motor neurons as an alternative to conventional electrodes. The stimulating electrode device consists of a spring coil-activated nerve clamp mounted inside a 1-mL syringe barrel. Supramaximal pulses were generated by a Grass stimulator and delivered to the nerve segment via the nerve clamp electrode. The salient feature of the electrode is its ability to produce muscle contractions indirectly through stimulation of the attached nerve. Indirect muscle stimulation is critical for studying the paralytic actions of presynaptic-acting toxins such as botulinum neurotoxins (BoNT), a potent inhibitor of acetylcholine (ACh) release from alpha motor neurons. This device enables stimulation of muscle contraction indirectly as opposed to contraction from direct muscle stimulation. The electrode is able to stimulate indirect muscle contraction when tested on ex vivo preparations from rodent phrenic nerve-hemidiaphragm muscle in similar fashion to conventional electrodes. In addition, the electrode stimulated external intercostal nerve-muscle preparations. This was confirmed after applying BoNT serotype A, a potent inhibitor of ACh release, to induce muscle paralysis. Alternative methods, including suction and bipolar loop electrodes, were unsuccessful in stimulating indirect muscle contraction. Therefore, this novel electrode is useful for physiological assessment of nerve agents and presynaptic actions of toxins that cause muscle paralysis. This electrode is useful for stimulating nerve-muscle preparations for which the length of nerve is a concern. C1 [Hilmas, Corey J.; Williams, Patrick T.] USA, Neurobehav Toxicol Branch, Med Res Inst Chem Def, Apg Ea, MD USA. [Scherer, John W.] USA, Informat Management Technol Off, Med Res Inst Chem Def, Apg Ea, MD USA. RP Williams, PT (reprint author), USA, Neurobehav Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM patrick.wil-liams23@us.army.mil NR 12 TC 0 Z9 0 U1 0 U2 3 PU BIOTECHNIQUES OFFICE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD OCT PY 2010 VL 49 IS 4 BP 739 EP + DI 10.2144/000113513 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 726KB UT WOS:000287719200009 PM 20964634 ER PT J AU Watson, M Abbott, KC Yuan, CM AF Watson, Maura Abbott, Kevin C. Yuan, Christina M. TI Damned If You Do, Damned If You Don't: Potassium Binding Resins in Hyperkalemia SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Editorial Material ID SODIUM POLYSTYRENE SULFONATE; CATION-EXCHANGE RESIN; INTESTINAL NECROSIS; SORBITOL; MANAGEMENT; KAYEXALATE; EARTHQUAKE; PATIENT; DISEASE AB Sodium polystyrene sulfonate (SPS) potassium binding resins increase colonic potassium excretion and are approved by the U.S. Food and Drug Administration (FDA) for the treatment of hyperkalemia. In 2009, the FDA recommended that sorbitol, a cathartic often given with SPS to prevent obstipation, not be added to SPS powder because of associated colonic necrosis. A premixed oral suspension of SPS in 33% sorbitol was not included in this warning. SPS resins increase stool potassium excretion in normokalemic subjects, but proportionately more potassium is excreted due to cathartics when the two are combined. In hyperkalemic patients, oral SPS mixed in water significantly decreases serum potassium within 24 hours. SPS/sorbitol-associated colonic necrosis is most commonly seen in patients who have received enemas in the setting of recent abdominal surgery, bowel injury, or intestinal dysfunction. It is a rare event, on the order of 0.2 to 0.3%, almost exclusively present in patients at risk. The agent most likely associated with colonic necrosis is 70% sorbitol, and animal data support that etiology. There is very little data to suggest that oral SPS given with 33% sorbitol (in the premixed form) or SPS powder in water orally or as an enema causes colonic necrosis. SPS ion-exchange resins are the only agents, other than dialysis and diuretics, available to increase potassium excretion in hyperkalemia, and when used appropriately, they appear to be clinically effective and reasonably safe. C1 [Watson, Maura; Abbott, Kevin C.; Yuan, Christina M.] Walter Reed Army Med Ctr, Serv Nephrol, Dept Med, Washington, DC 20307 USA. RP Yuan, CM (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Dept Med, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM christina.yuan@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 24 TC 41 Z9 41 U1 0 U2 2 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD OCT PY 2010 VL 5 IS 10 BP 1723 EP 1726 DI 10.2215/CJN.03700410 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 662TS UT WOS:000282836400001 PM 20798253 ER PT J AU Ochoa, LM Dawson, L Patzkowski, JC Hsu, JR AF Ochoa, Leah M. Dawson, Laura Patzkowski, Jeanne C. Hsu, Joseph R. TI Radiographic Prevalence of Femoroacetabular Impingement in a Young Population with Hip Complaints Is High SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID EARLY OSTEOARTHRITIS; ABNORMALITIES AB Femoroacetabular impingement (FAI) is reportedly a prearthritic condition in young adults that can progress to osteoarthritis. However, the prevalence of FAI is unknown in the young, active population presenting with hip complaints. We sought to determine (1) the prevalence of radiographic findings of FAI in a young, active patient population with complaints localized to the region of the hip presenting to primary care and orthopaedic clinics; (2) the percentage of films with FAI with an official reading suggesting the diagnosis; and (3) whether the Tonnis grades of osteoarthritis corresponded to the findings of FAI. We performed a database review of pelvic and hip radiographs obtained from 157 young (mean age 32 years; range, 18-50 years) patients presenting with hip-related complaints to primary care and orthopaedic clinics. Radiographs were analyzed for signs of FAI (herniation pits, pistol grip deformity, center-edge angle, alpha angle, and crossover sign) and Tonnis grade. Radiology reports were reviewed for a diagnosis of FAI. At least one finding of FAI was found in 135 of the 155 patients (87%). Four hundred thirteen of 487 radiographs (85%) had been read as normal and one read as showing FAI. Tonnis grades did not correlate with radiographic signs of FAI. Radiographic evidence of FAI is common in active patients with hip complaints. Increased awareness of FAI in primary care, radiology, and orthopaedic clinics and additional research into the long-term effects of management are warranted. Level II, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence. C1 [Patzkowski, Jeanne C.] Brooke Army Med Ctr, Orthopaed Surg Serv, Ft Sam Houston, TX 78234 USA. [Ochoa, Leah M.; Dawson, Laura] William Beaumont Army Med Ctr, Orthopaed Surg Serv, El Paso, TX 79920 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Orthopaed Surg Serv, Ft Sam Houston, TX 78234 USA. RP Patzkowski, JC (reprint author), Brooke Army Med Ctr, Orthopaed Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeanne.patzkowski2@amedd.army.mil NR 13 TC 42 Z9 43 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD OCT PY 2010 VL 468 IS 10 BP 2710 EP 2714 DI 10.1007/s11999-010-1233-8 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 650IT UT WOS:000281843200021 PM 20107939 ER PT J AU Chung, KK Wolf, SE Renz, EM Allan, PF Aden, JK Merrill, GA Shelhamer, MC King, BT White, CE Bell, DG Schwacha, MG Wanek, SM Wade, CE Holcomb, JB Blackbourne, LH Cancio, LC AF Chung, Kevin K. Wolf, Steven E. Renz, Evan M. Allan, Patrick F. Aden, James K. Merrill, Gerald A. Shelhamer, Mehdi C. King, Booker T. White, Christopher E. Bell, David G. Schwacha, Martin G. Wanek, Sandra M. Wade, Charles E. Holcomb, John B. Blackbourne, Lorne H. Cancio, Leopoldo C. TI High-frequency percussive ventilation and low tidal volume ventilation in burns: A randomized controlled trial SO CRITICAL CARE MEDICINE LA English DT Article DE burns; high frequency; percussive ventilation; low-tidal volume ventilation; inhalation injury ID ACUTE LUNG INJURY; ACUTE RESPIRATORY-DISTRESS; INHALATION INJURY; CONVENTIONAL VENTILATION; MECHANICAL VENTILATION; IMPROVES OXYGENATION; MILITARY CASUALTIES; SMOKE-INHALATION; RESUSCITATION; ARDS AB Objectives: In select burn intensive care units, high-frequency percussive ventilation is preferentially used to provide mechanical ventilation in support of patients with acute lung injury, acute respiratory distress syndrome, and inhalation injury. However, we found an absence of prospective studies comparing high-frequency percussive ventilation with contemporary low-tidal volume ventilation strategies. The purpose of this study was to prospectively compare the two ventilator modalities in a burn intensive care unit setting. Design: Single-center, prospective, randomized, controlled clinical trial, comparing high-frequency percussive ventilation with low-tidal volume ventilation in patients admitted to our burn intensive care unit with respiratory failure. Setting: A 16-bed burn intensive care unit at a tertiary military teaching hospital. Patients: Adult patients >= 18 yrs of age requiring prolonged (>24 hrs) mechanical ventilation were admitted to the burn intensive care unit. The study was conducted over a 3-yr period between April 2006 and May 2009. This trial was registered with ClinicalTrials.gov as NCT00351741. Interventions: Subjects were randomly assigned to receive mechanical ventilation through a high-frequency percussive ventilation-based strategy (n = 31) or a low-tidal volume ventilation-based strategy (n = 31). Measurements and Main Results: At baseline, both the high-frequency percussive ventilation group and the low-tidal volume ventilation group had similar demographics to include median age (interquartile range) (28 yrs [23-45] vs. 33 yrs [24-46], p = nonsignificant), percentage of total body surface area burn (34 [20-52] vs. 34 [23-50], p = nonsignificant), and clinical diagnosis of inhalation injury (39% vs. 35%, p = nonsignificant). The primary outcome was ventilator-free days in the first 28 days after randomization. Intent-to-treat analysis revealed no significant difference between the high-frequency percussive ventilation and the low-tidal volume ventilation groups in mean (+/- SD) ventilator-free days (12 +/- 9 vs. 11 +/- 9, p = nonsignificant). No significant difference was detected between groups for any of the secondary outcome measures to include mortality except the need for "rescue" mode application (p = .02). Nine (29%) in the low-tidal volume ventilation arm did not meet predetermined oxygenation or ventilation goals and required transition to a rescue mode. By contrast, two in the high-frequency percussive ventilation arm (6%) required rescue. Conclusions: A high-frequency percussive ventilation-based strategy resulted in similar clinical outcomes when compared with a low-tidal volume ventilation-based strategy in burn patients with respiratory failure. However, the low-tidal volume ventilation strategy failed to achieve ventilation and oxygenation goals in a higher percentage necessitating rescue ventilation. (Crit Care Med 2010; 38: 1970-1977) C1 [Chung, Kevin K.; Wolf, Steven E.; Renz, Evan M.; Aden, James K.; King, Booker T.; White, Christopher E.; Wade, Charles E.; Blackbourne, Lorne H.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.; Wolf, Steven E.; Renz, Evan M.; White, Christopher E.; Schwacha, Martin G.; Wade, Charles E.; Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Allan, Patrick F.; Wanek, Sandra M.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Merrill, Gerald A.; Shelhamer, Mehdi C.; Bell, David G.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM Kevin.chung@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU Department of Clinical Investigations FX We specifically acknowledge the tremendous work done by our research and regulatory staff to facilitate the conduct of this trial: Chaya M. Galin, RN, CNOR; Michelle L. Morrow, RN; Elsa C. Coates, RN, BSN, CCRN; Annette R. McClinton, RN, BSN, MA; Lynn S. Platteborze, MS, RAC; Michael Perez, MS; Nancy C. Molter, RN, PhD; Elizabeth A. Frail, RN, BSN; Peggy A. Bielke, RN, BSN; and Kari Williams, RN, BSN. We further acknowledge the laboratory support of the Department of Clinical Investigations by Kimberly Farrow, David Ho, Lisa Perez, and Houston Kim in conducting the cytokine analyses. We also especially thank John Jones, MS, for his statistical analysis during the planning stages of this trial; Denise Jimenez, CRT, for contributing her time for data entry and verification; and Otilia Sanchez, for proofing the final manuscript. Finally, we are indebted to the burn intensive care unit nurses and respiratory therapists without whom this work would not be possible. NR 43 TC 45 Z9 45 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD OCT PY 2010 VL 38 IS 10 BP 1970 EP 1977 DI 10.1097/CCM.0b013e3181eb9d0b PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 652XB UT WOS:000282043800007 PM 20639746 ER PT J AU Rees, DI Sabia, JJ AF Rees, Daniel I. Sabia, Joseph J. TI Sports participation and academic performance: Evidence from the National Longitudinal Study of Adolescent Health SO ECONOMICS OF EDUCATION REVIEW LA English DT Article DE Sports participation; Academic performance; Educational economics ID LABOR-MARKET OUTCOMES; SCHOOL ATHLETIC PARTICIPATION; EXTRACURRICULAR INVOLVEMENT; WEAK INSTRUMENTS; EDUCATION; HEIGHT; RACE AB It has been argued that high school sports participation increases motivation and teaches teamwork and self-discipline. While several studies have shown that students who participate in athletic activities perform better in school than those who do not, it is not clear whether this association is a result of positive academic spillovers, or due to the influence of unobservables. Using data from the National Longitudinal Study of Adolescent Health and a variety of statistical techniques designed to distinguish between these hypotheses, we examine the effect of sports participation on several measures of academic performance. Our results provide only limited evidence that sports participation leads to enhanced academic performance. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Rees, Daniel I.] Univ Colorado, Dept Econ, Denver, CO 80217 USA. [Sabia, Joseph J.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. RP Rees, DI (reprint author), Univ Colorado, Dept Econ, CB 181,POB 173364, Denver, CO 80217 USA. EM Daniel.Rees@ucdenver.edu; Joe_Sabia@yahoo.com NR 23 TC 19 Z9 19 U1 5 U2 32 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0272-7757 J9 ECON EDUC REV JI Econ. Educ. Rev. PD OCT PY 2010 VL 29 IS 5 BP 751 EP 759 DI 10.1016/j.econedurev.2010.04.008 PG 9 WC Economics; Education & Educational Research SC Business & Economics; Education & Educational Research GA 645OF UT WOS:000281471000006 ER PT J AU Lotufo, GR Gibson, AB Yoo, JL AF Lotufo, Guilherme R. Gibson, Alfreda B. Yoo, J. Leslie TI Toxicity and bioconcentration evaluation of RDX and HMX using sheepshead minnows in water exposures SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Explosives; RDX; HMX; Toxicity; Bioaccumulation; Critical body residue; Cyprinodon variegatus ID ZEBRAFISH DANIO-RERIO; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; MUNITIONS CONSTITUENTS; PIMEPHALES-PROMELAS; EXPLOSIVE COMPOUNDS; 2,4,6-TRINITROTOLUENE; INVERTEBRATES; ORDNANCE; FATE AB Lethal effects of the explosives RDX and HMX were assessed using ten-day water exposures to juvenile sheepshead minnows Cyprinodon variegatus). For RDX, maximum mortality occurred during the first two days of exposure with a 10-d median lethal concentration (LC50) of 9.9 mg L(-1). The RDX 10-d median lethal residue (LR50) was 9.6 mg kg(-1) (34.9 pmol kg(-1)) wet weight (ww), the first RDX critical body residue reported for fish. Previous investigations reported that RDX body residues in marine amphipods up to 96 pmol kg-1 ww and in marine mussels up to 86 pmol kg-1 ww failed to result in significant mortality. The highest HMX concentration tested, corresponding to its apparent solubility limit in seawater (2.0 mg L(-1)), and the associated mean body residue (3 mg kg(-1) or 14 pmol kg(-1) ww) resulted in no significant mortality for exposed minnows. The mean 10-d bioconcentration factors for RDX (0.6-0.9 L kg-1) and HMX (0.3-1.6 L kg(-1)) were typically lower than 1, reflecting the low bioaccumulative potential for these compounds. Published by Elsevier Inc. C1 [Lotufo, Guilherme R.; Gibson, Alfreda B.; Yoo, J. Leslie] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU The US Navy; U.S. Army FX The US Navy Environmental Sustainability Development to Integration Program and the Environmental Quality Technology Research Program of the U.S. Army supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N456) and the Chief of Engineers. The authors thank Daniel Farrar for high performance liquid chromatography analyses. We are grateful to Robert George, Bill Wild, Gunther Rosen, Allan Kennedy, M. John Cullinane and Elizabeth Ferguson for their review of this manuscript. The U.S. Navy's Environmental Sustainability Development to Integration Program and the Installation Restoration Research Program of the U.S. Army Corps of Engineers supported this research. NR 36 TC 5 Z9 5 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD OCT PY 2010 VL 73 IS 7 BP 1653 EP 1657 DI 10.1016/j.ecoenv.2010.02.006 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 662FH UT WOS:000282792300023 PM 20188417 ER PT J AU Lotufo, GR Blackburn, W Marlborough, SJ Fleeger, JW AF Lotufo, Guilherme R. Blackburn, William Marlborough, Sydney J. Fleeger, John W. TI Toxicity and bioaccumulation of TNT in marine fish in sediment exposures SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Explosives; TNT; Sediment; Bioaccumulation; Cyprinodon variegatus; Hypsoblennius ionthas ID MINNOW CYPRINODON-VARIEGATUS; EARTHWORM EISENIA-ANDREI; LIFE-CYCLE TOXICITY; AROMATIC-HYDROCARBONS; SHEEPSHEAD MINNOWS; 2,4,6-TRINITROTOLUENE; SOIL; FATE; TRANSFORMATION; EXPLOSIVES AB The bioaccumulation potential and toxicity of 2,4,6-trinitrotoluene (TNT) spiked to sediment was evaluated in juvenile sheepshead minnows (JSHM, Cyprinodon variegatus) and adult freckled blennies (FB, Hypsoblennius ionthas). The JSHM were exposed for 4 days in the presence or absence of a mesh separating fish from sediment. FB were exposed to sediment for 7 days. During the 24-day storage period (4 degrees C), extensive transformation of spiked TNT occurred and concentrations are expressed as the sum of TNT, aminodinitrotoluenes and diaminonitrotoluenes (SumTNT), on a dry weight basis. SumTNT in the overlying water, not exchanged during exposure, increased gradually. Survival was high (>= 90%) for JSHM exposed to 7 mg kg(-1) and FB exposed to up to 260 mg kg(-1). All SHM died after 24 h exposure to 340 mg kg(-1). Isolation from sediment did not significantly affect water concentrations or decrease bioaccumulation. Uptake from contact to sediment was likely negligible and bioaccumulation was from the overlying water. The feeding rate of FB exposed to 1700 mu mol kg(-1) sediment suspended in water for 24-h was significantly reduced by 50%. Published by Elsevier Inc. C1 [Lotufo, Guilherme R.; Blackburn, William] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Marlborough, Sydney J.; Fleeger, John W.] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA. RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil RI Fleeger, John/A-6215-2013 FU US Navy; US Army; Chief of Naval Operations [N456] FX The US Navy Environmental Sustainability Development to Integration Program and the Environmental Quality Technology Research Program of the US Army supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N456) and the Chief of Engineers. The authors thank Daniel Farrar for high-performance liquid chromatography analyses. We are grateful to Gunther Rosen, Robert George, Stanley Jacob, M. John Cullinane and Elizabeth Ferguson for their review of this manuscript. NR 38 TC 10 Z9 10 U1 2 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD OCT PY 2010 VL 73 IS 7 BP 1720 EP 1727 DI 10.1016/j.ecoenv.2010.02.009 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 662FH UT WOS:000282792300033 PM 20189649 ER PT J AU Abel, MT Suedel, B Presley, SM Rainwater, TR Austin, GP Cox, SB McDaniel, LN Rigdon, R Goebel, T Zartman, R Leftwich, BD Anderson, TA Kendall, RJ Cobb, GP AF Abel, Michael T. Suedel, Burton Presley, Steven M. Rainwater, Thomas R. Austin, Galen P. Cox, Stephen B. McDaniel, Les N. Rigdon, Richard Goebel, Timothy Zartman, Richard Leftwich, Blair D. Anderson, Todd A. Kendall, Ronald J. Cobb, George P. TI Spatial distribution of lead concentrations in urban surface soils of New Orleans, Louisiana USA SO ENVIRONMENTAL GEOCHEMISTRY AND HEALTH LA English DT Article DE Trace metals; Lead; Spatial distribution; New Orleans ID HURRICANE-KATRINA; BLOOD LEAD; SEDIMENTS; EXPOSURE; RITA AB Immediately following hurricane Katrina concern was raised over the environmental impact of floodwaters on the city of New Orleans, especially in regard to human health. Several studies were conducted to determine the actual contaminant distribution throughout the city and surrounding wetlands by analyzing soil, sediment, and water for a variety of contaminants including organics, inorganics, and biologics. Preliminary investigations by The Institute of Environmental and Human Health at Texas Tech University concluded that soils and sediments contained pesticides, semi-volatiles, and metals, specifically arsenic, iron, and lead, at concentrations that could pose a significant risk to human health. Additional studies on New Orleans floodwaters revealed similar constituents as well as compounds commonly found in gasoline. More recently, it has been revealed that lead (Pb), arsenic, and vanadium are found intermittently throughout the city at concentrations greater than the human health soil screening levels (HHSSLs) of 400, 22 (non-cancer endpoint) and 390 mu g/g, respectively. Of these, Pb appears to present the greatest exposure hazard to humans as a result of its extensive distribution in city soils. In this study, we spatially evaluated Pb concentrations across greater New Orleans surface soils. We established 128 sampling sites throughout New Orleans at approximately half-mile intervals. A soil sample was collected at each site and analyzed for Pb by ICP-AES. Soils from 19 (15%) of the sites had Pb concentrations exceeding the HHSSL threshold of 400 mu g/g. It was determined that the highest concentrations of Pb were found in the south and west portions of the city. Pb concentrations found throughout New Orleans in this study were then incorporated into a geographic information system to create a spatial distribution model that can be further used to predict Pb exposure to humans in the city. C1 [Abel, Michael T.; Presley, Steven M.; Rainwater, Thomas R.; Austin, Galen P.; Cox, Stephen B.; McDaniel, Les N.; Anderson, Todd A.; Kendall, Ronald J.; Cobb, George P.] Texas Tech Univ, Dept Environm Toxicol, Inst Environm & Human Hlth, Lubbock, TX 79409 USA. [Rigdon, Richard; Goebel, Timothy; Leftwich, Blair D.] TraceAnalysis Inc, Lubbock, TX 79424 USA. [Suedel, Burton] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Zartman, Richard] Texas Tech Univ, Dept Plant & Soil Sci, Lubbock, TX 79409 USA. RP Abel, MT (reprint author), Texas Tech Univ, Dept Environm Toxicol, Inst Environm & Human Hlth, Box 41163, Lubbock, TX 79409 USA. EM michael.abel@tiehh.ttu.edu NR 27 TC 12 Z9 13 U1 1 U2 24 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0269-4042 J9 ENVIRON GEOCHEM HLTH JI Environ. Geochem. Health PD OCT PY 2010 VL 32 IS 5 BP 379 EP 389 DI 10.1007/s10653-009-9282-1 PG 11 WC Engineering, Environmental; Environmental Sciences; Public, Environmental & Occupational Health; Water Resources SC Engineering; Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Water Resources GA 651OG UT WOS:000281936400001 PM 20054703 ER PT J AU Uchimiya, M Gorb, L Isayev, O Qasim, MM Leszczynski, J AF Uchimiya, Minori Gorb, Leonid Isayev, Olexandr Qasim, Mohammad M. Leszczynski, Jerzy TI One-electron standard reduction potentials of nitroaromatic and cyclic nitramine explosives SO ENVIRONMENTAL POLLUTION LA English DT Article DE Reduction potential; Explosives; Electron transfer; Nitroaromatic compounds; Cyclic nitramine ID ABIOTIC REDUCTION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; QUINONE DERIVATIVES; ENERGETIC COMPOUNDS; AQUEOUS-SOLUTION; N-15 NMR; FE(II); TRANSFORMATION; CL-20; IRON AB Extensive studies have been conducted in the past decades to predict the environmental abiotic and biotic redox fate of nitroaromatic and nitramine explosives. However, surprisingly little information is available on one-electron standard reduction potentials (E(o)(R-NO(2)/R-NO(2)(-))). The E(o)(R-NO(2)/R-NO(2)(-)) is an essential thermodynamic parameter for predicting the rate and extent of reductive transformation for energetic residues. In this study, experimental (linear free energy relationships) and theoretical (ab initio calculation) approaches were employed to determine E(o)(R-NO(2)/R-NO(2)(-)) for nitroaromatic, (caged) cyclic nitramine, and nitroimino explosives that are found in military installations or are emerging contaminants. The results indicate a close agreement between experimental and theoretical E(o)(R-NO(2)/R-NO(2)(-)) and suggest a key trend: E(o)(R-NO(2)/R-NO(2)(-)) value decreases from di- and tri-nitroaromatic (e.g., 2,4-dinitroanisole) to nitramine (e.g., RDX) to nitroimino compound (e.g., nitroguanidine). The observed trend in E(o)(R-NO(2)/R-NO(2)(-) agrees with reported rate trends for reductive degradation, suggesting a thermodynamic control on the reduction rate under anoxic/suboxic conditions. Published by Elsevier Ltd. C1 [Uchimiya, Minori; Qasim, Mohammad M.; Leszczynski, Jerzy] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Gorb, Leonid] SpecPro Inc, Vicksburg, MS 39180 USA. [Isayev, Olexandr] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. [Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Ctr Nanotoxic, Jackson, MS 39217 USA. RP Uchimiya, M (reprint author), USDA ARS, So Reg Res Ctr, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov RI Isayev, Olexandr/B-7944-2008 OI Isayev, Olexandr/0000-0001-7581-8497 FU Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS FX This project was supported by the U.S. Army Environmental Quality Technology Program at the Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS. NR 42 TC 22 Z9 22 U1 3 U2 43 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD OCT PY 2010 VL 158 IS 10 BP 3048 EP 3053 DI 10.1016/j.envpol.2010.06.033 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 655OV UT WOS:000282260200007 PM 20656388 ER PT J AU Do, Y Koh, H Park, CG Dudziak, D Seo, P Mehandru, S Choi, JH Cheong, C Park, S Perlin, DS Powell, BS Steinman, RM AF Do, Yoonkyung Koh, Hyein Park, Chae Gyu Dudziak, Diana Seo, Patrick Mehandru, S. Choi, Jae-Hoon Cheong, Cheolho Park, Steven Perlin, David S. Powell, Bradford S. Steinman, Ralph M. TI Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE CD205/DEC-205; DCIR2; DC; LcrV; Yersinia pestis ID NECROSIS-FACTOR-ALPHA; GAMMA-INTERFERON; FUSION PROTEIN; T-CELLS; IN-VIVO; INFECTION; IMMUNITY; ANTIGEN; VACCINE; DEFENSE AB To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8 alpha(+) DEC-205(+) or CD8 alpha(-) DCIR2(+) DC along with a clinically feasible adjuvant, poly IC By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC-targeted LcrV induced polarized Th1 immunity, whereas DCIR2-targeted LcrV induced fewer CD4(+) T cells secreting IFN-gamma, but higher IL-4, IL-5, IL-10, and IL-13 production. DCIR-2 targeting elicited higher anti-LcrV Ab titers than DEC targeting, which were comparable to a protein vaccine given in alhydrogel adjuvant, but the latter did not induce detectable T-cell immunity. When DEC- and DCIR2-targeted and F1-V+ alhydrogel-vaccinated mice were challenged 6 wk after vaccination with the virulent CO92 Y. pestis, the protection level and Ab titers induced by DCIR2 targeting were similar to those induced by F1-V protein with alhydrogel vaccination. Therefore, LcrV targeting to DC elicits combined humoral and cellular immunity, and for the first time with this approach, also induces protection in a mouse model for a human pathogen. C1 [Do, Yoonkyung; Koh, Hyein; Park, Chae Gyu; Seo, Patrick; Mehandru, S.; Choi, Jae-Hoon; Cheong, Cheolho; Steinman, Ralph M.] Rockefeller Univ, Lab Cellular Physiol & Immunol, New York, NY 10021 USA. [Do, Yoonkyung; Koh, Hyein; Park, Chae Gyu; Seo, Patrick; Mehandru, S.; Choi, Jae-Hoon; Cheong, Cheolho; Steinman, Ralph M.] Rockefeller Univ, Chris Browne Ctr, New York, NY 10021 USA. [Do, Yoonkyung] Ulsan Natl Inst Sci & Technol, Sch Nanobiotechnol & Chem Engn, Ulsan, South Korea. [Dudziak, Diana] Univ Hosp Erlangen, Nikolaus Fiebiger Ctr Mol Med, Dept Dermatol, Lab Dendrit Cell Biol, Erlangen, Germany. [Park, Steven; Perlin, David S.] UMDNJ New Jersey Med Sch, Int Ctr Publ Hlth, Publ Hlth Res Inst, Newark, NJ USA. [Powell, Bradford S.] USA, Med Res Inst Infect Dis, USAMRIID, Bacteriol Div, Frederick, MD USA. RP Do, Y (reprint author), Rockefeller Univ, Lab Cellular Physiol & Immunol, 1230 York Ave, New York, NY 10021 USA. EM doy@unist.ac.kr RI Steinman, Ralph/F-7729-2012; OI Park, Chae Gyu/0000-0003-1906-1308; Dudziak, Diana/0000-0001-9358-134X FU National Institutes of Health [5 U54 AI057158, AI13013]; NBC; NIH/NIAID [1R21AI082331-01]; Korea Government (MEST) [2010-0002810]; German Research Foundation [DU548/1-1, DU548/2-1] FX The authors thank H. Zebroski of the Rockefeller University Proteomics Facility for synthesizing peptides, J. Adams for help with graphics, and Guillame Delmas and Senina Svetlana of the Public Health Research Institute for technical support. This work was supported by the National Institutes of Health (#5 U54 AI057158, PI-Lipkin and AI13013, PI RMS). Animal studies were performed in the Northeast Biodefense Center (NBC) Animal Core facility (Newark, NJ). Y. Do was supported by a Postdoctoral Fellowship through the NBC Career Development Program, and NIH/NIAID Exploratory/Development grant (1R21AI082331-01). This work was also supported by the 2009 Research Fund of the Ulsan National Institute of Science and Technology (UNIST, #1.090022), and the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST, #2010-0002810). D. Dudziak was supported by the German Research Foundation (DU548/1-1 and DU548/2-1). The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 22 TC 23 Z9 25 U1 0 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD OCT PY 2010 VL 40 IS 10 BP 2791 EP 2796 DI 10.1002/eji.201040511 PG 6 WC Immunology SC Immunology GA 669YY UT WOS:000283387500017 PM 20812236 ER PT J AU Zhang, YH Ryan, DS Bower, KS Ilan, N Vlodavsky, I Laurie, GW AF Zhang, Yinghui Ryan, Denise S. Bower, Kraig S. Ilan, Neta Vlodavsky, Israel Laurie, Gordon W. TI Focus on Molecules: Heparanase SO EXPERIMENTAL EYE RESEARCH LA English DT Article DE dry eye; cornea; tears; syndecan; HPSE; cancer; inflammation; ocular surface C1 [Zhang, Yinghui; Laurie, Gordon W.] Univ Virginia, Dept Cell Biol, UVa Hlth Syst, Charlottesville, VA 22908 USA. [Ryan, Denise S.; Bower, Kraig S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Washington, DC 20307 USA. [Ilan, Neta; Vlodavsky, Israel] Technion Israel Inst Technol, Rappaport Fac Med, Canc & Vasc Biol Res Ctr, IL-31096 Haifa, Israel. RP Laurie, GW (reprint author), Univ Virginia, Dept Cell Biol, UVa Hlth Syst, POB 800732, Charlottesville, VA 22908 USA. EM glaurie@virginia.edu FU NIH [RO1 EY13143, EY018222, RO1 CA106456] FX Supported by NIH RO1 EY13143 and EY018222 to GWL, and NIH RO1 CA106456 to IV. NR 4 TC 3 Z9 3 U1 0 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0014-4835 J9 EXP EYE RES JI Exp. Eye Res. PD OCT PY 2010 VL 91 IS 4 BP 476 EP 477 DI 10.1016/j.exer.2010.05.004 PG 2 WC Ophthalmology SC Ophthalmology GA 655PH UT WOS:000282261400001 PM 20478306 ER PT J AU Tannenbaum, LV AF Tannenbaum, Lawrence V. TI ERA lessons from the ocean floor SO FRONTIERS IN ECOLOGY AND THE ENVIRONMENT LA English DT Editorial Material C1 USA, Publ Hlth Command Prov, Aberdeen Proving Ground, MD USA. RP Tannenbaum, LV (reprint author), USA, Publ Hlth Command Prov, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1540-9295 J9 FRONT ECOL ENVIRON JI Front. Ecol. Environ. PD OCT PY 2010 VL 8 IS 8 BP 395 EP 395 DI 10.1890/1540-9295-8.8.385 PG 1 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 660PL UT WOS:000282655500001 ER PT J AU Moawad, FJ Gentry, AB Humphries, A Young, PE AF Moawad, Fouad J. Gentry, Andrew B. Humphries, Ashley Young, Patrick E. TI An unusual case of acute pancreatitis secondary to an intraluminal duodenal diverticulum SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 [Moawad, Fouad J.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. [Gentry, Andrew B.; Humphries, Ashley; Young, Patrick E.] Natl Naval Med Ctr, Div Gastroenterol, Bethesda, MD USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. NR 0 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD OCT PY 2010 VL 72 IS 4 BP 847 EP 848 DI 10.1016/j.gie.2010.03.1055 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 663ZB UT WOS:000282927600031 PM 20541753 ER PT J AU Le Roux, JP Demirbilek, Z Brodalka, M Flemming, BW AF Le Roux, Jacobus P. Demirbilek, Zeki Brodalka, Marysia Flemming, Burghard W. TI WAVECALC: an Excel-VBA spreadsheet to model the characteristics of fully developed waves and their influence on bottom sediments in different water depths SO GEO-MARINE LETTERS LA English DT Article ID OSCILLATORY SHEET FLOW; SHALLOW-WATER; CNOIDAL WAVE; DETERMINE WAVELENGTH; BEDLOAD TRANSPORT; UNIFIED CRITERION; THRESHOLD; BREAKING; MOTION; INITIATION AB The generation and growth of waves in deep water is controlled by winds blowing over the sea surface. In fully developed sea states, where winds and waves are in equilibrium, wave parameters may be calculated directly from the wind velocity. We provide an Excel spreadsheet to compute the wave period, length, height and celerity, as well as horizontal and vertical particle velocities for any water depth, bottom slope, and distance below the reference water level. The wave profile and propagation can also be visualized for any water depth, modeling the sea surface change from sinusoidal to trochoidal and finally cnoidal profiles into shallow water. Bedload entrainment is estimated under both the wave crest and the trough, using the horizontal water particle velocity at the top of the boundary layer. The calculations are programmed in an Excel file called WAVECALC, which is available online to authorized users. Although many of the recently published formulas are based on theoretical arguments, the values agree well with several existing theories and limited field and laboratory observations. WAVECALC is a user-friendly program intended for sedimentologists, coastal engineers and oceanographers, as well as marine ecologists and biologists. It provides a rapid means to calculate many wave characteristics required in coastal and shallow marine studies, and can also serve as an educational tool. C1 [Le Roux, Jacobus P.] Univ Chile, Fac Ciencias Fis & Matemat, Dept Geol, Santiago, Chile. [Demirbilek, Zeki] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Brodalka, Marysia] Univ Pretoria, ZA-0002 Pretoria, South Africa. [Flemming, Burghard W.] Senckenberg Inst, Dept Marine Sci, D-26382 Wilhelmshaven, Germany. RP Le Roux, JP (reprint author), Univ Chile, Fac Ciencias Fis & Matemat, Dept Geol, Casilla 13518,Correo 21, Santiago, Chile. EM jroux@cec.uchile.cl RI Le Roux, Jacobus/A-9765-2008 OI Le Roux, Jacobus/0000-0003-0173-4471 FU Hanse Institute for Advanced Study in Delmenhorst, Germany; U.S. Army Engineer RD Center FX JPLR gratefully acknowledges the financial and logistical support of the Hanse Institute for Advanced Study in Delmenhorst, Germany, where this study was initiated during 2006. This research was supported by the Navigation System program, U.S. Army Engineer R&D Center (for ZD). Permission was granted by Headquarters, U.S. Army Corps of Engineers, to publish this information. Several anonymous reviewers of previous versions are thanked for their valuable input. NR 55 TC 4 Z9 4 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0276-0460 J9 GEO-MAR LETT JI Geo-Mar. Lett. PD OCT PY 2010 VL 30 IS 5 BP 549 EP 560 DI 10.1007/s00367-010-0195-x PG 12 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 650JO UT WOS:000281845300007 ER PT J AU Kardol, P Campany, CE Souza, L Norby, RJ Weltzin, JF Classen, AT AF Kardol, Paul Campany, Courtney E. Souza, Lara Norby, Richard J. Weltzin, Jake F. Classen, Aimee T. TI Climate change effects on plant biomass alter dominance patterns and community evenness in an experimental old-field ecosystem SO GLOBAL CHANGE BIOLOGY LA English DT Article DE community composition; diversity; drought; elevated [CO(2)]; Lespedeza cuneata; old-fields; precipitation; soil moisture; temperature; warming ID GLOBAL ENVIRONMENTAL-CHANGES; ELEVATED AIR-TEMPERATURE; CO2 ENRICHMENT; TERRESTRIAL ECOSYSTEMS; SPECIES RICHNESS; ATMOSPHERIC CO2; SOIL-MOISTURE; CALCAREOUS GRASSLAND; CONCEPTUAL-FRAMEWORK; WATER AVAILABILITY AB Atmospheric and climatic change can alter plant biomass production and plant community composition. However, we know little about how climate change-induced alterations in biomass production affect plant species composition. To better understand how climate change will alter both individual plant species and community biomass, we manipulated atmospheric [CO(2)], air temperature, and precipitation in a constructed old-field ecosystem. Specifically, we compared the responses of dominant and subdominant species to our climatic treatments, and explored how changes in plant dominance patterns alter community evenness over 2 years. Our study resulted in four major findings: (1) all treatments, elevated [CO(2)], warming, and increased precipitation increased plant community biomass and the effects were additive rather than interactive, (2) plant species differed in their response to the treatments, resulting in shifts in the proportional biomass of individual species, which altered the plant community composition; however, the plant community response was largely driven by the positive precipitation response of Lespedeza, the most dominant species in the community, (3) precipitation explained most of the variation in plant community composition among treatments, and (4) changes in precipitation caused a shift in the dominant species proportional biomass that resulted in lower community evenness in the wet relative to dry treatments. Interestingly, compositional and evenness responses of the subdominant community to the treatments did not always follow the responses of the whole plant community. Our data suggest that changes in plant dominance patterns and community evenness are an important part of community responses to climatic change, and generally, that such compositional shifts can alter ecosystem biomass production and nutrient inputs. C1 [Kardol, Paul; Norby, Richard J.] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. [Kardol, Paul; Campany, Courtney E.; Souza, Lara; Weltzin, Jake F.; Classen, Aimee T.] Univ Tennessee, Dept Ecol & Evolutionary Biol, Knoxville, TN 37996 USA. [Weltzin, Jake F.] USA, Natl Phenol Network, Tucson, AZ 85721 USA. RP Kardol, P (reprint author), Swedish Univ Agr Sci, Dept Forest Ecol & Management, S-90183 Umea, Sweden. EM Paul.Kardol@seksko.slu.se RI Kardol, Paul/A-2600-2010; Classen, Aimee/C-4035-2008; Norby, Richard/C-1773-2012; Kardol, Paul/N-8383-2015 OI Classen, Aimee/0000-0002-6741-3470; Norby, Richard/0000-0002-0238-9828; Kardol, Paul/0000-0001-7065-3435 FU U.S. Department of Energy, Office of Science, Biological and Environmental Research, Program for Ecosystem Research with Oak Ridge National Laboratory (ORNL) [DE-AC05-00OR22725, DE-FG02-02ER63366] FX E. Austin, J. Bevans, G. Byrd, C. Garten, H. Castro, D. Brice, J. Childs, S. Childs, O. Dermody, C. Engel, E. Felker-Quinn, E. Ferguson, M.-A. de Graaff, D. Hui, C. Iversen, G. Jimenez, Z. Kiershmann, O. Mnzawa, W. N. Reynolds, K. Rula, K. Sides, and J. Warren all assisted with long days of sample collection. P. Allen was pivotal in setting up the experiment. This research was sponsored by the U.S. Department of Energy, Office of Science, Biological and Environmental Research, Program for Ecosystem Research under contract DE-AC05-00OR22725 with Oak Ridge National Laboratory (ORNL), managed by UT-Battelle, L. L. C., and through grant DE-FG02-02ER63366 to the University of Tennessee. NR 78 TC 85 Z9 90 U1 6 U2 120 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1354-1013 J9 GLOBAL CHANGE BIOL JI Glob. Change Biol. PD OCT PY 2010 VL 16 IS 10 BP 2676 EP 2687 DI 10.1111/j.1365-2486.2010.02162.x PG 12 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 648FV UT WOS:000281676700004 ER PT J AU Clark, PJ Thompson, AJ Zhu, MF Zhu, QQ Ge, DL Sulkowski, MS Tillmann, HL Patel, K Naggie, S Muir, AJ Afdhal, NH Jacobson, IM Esteban, R Lawitz, E Poordad, F Shiffman, ML Galler, GW Harrison, S King, JW Kwo, PY Nyberg, LM McCone, J Lee, WM Reindollar, R Ghalib, RH Freilich, B Goodman, Z Boparai, N Koury, KJ Noviello, S Pedicone, L Brass, CA Albrecht, JK Goldstein, DB McHutchison, JG AF Clark, Paul J. Thompson, Alexander J. Zhu, Mingfu Zhu, Qianqian Ge, Dongliang Sulkowski, Mark S. Tillmann, Hans L. Patel, Keyur Naggie, Susanna Muir, Andrew J. Afdhal, Nezam H. Jacobson, Ira M. Esteban, Rafael Lawitz, Eric Poordad, Fred Shiffman, Mitchell L. Galler, Greg Wayne Harrison, Stephen King, John W. Kwo, Paul Y. Nyberg, Lisa M. McCone, Jonathan Lee, William M. Reindollar, Robert Ghalib, Reem H. Freilich, Bradley Goodman, Zachary Boparai, Navdeep Koury, Kenneth J. Noviello, Stephanie Pedicone, Lisa Brass, Clifford A. Albrecht, Janice K. Goldstein, David B. McHutchison, John G. TI IL28B GENETIC POLYMORPHISM HAS GENOME WIDE SIGNIFICANT ASSOCIATIONS WITH SERUM LOW DENSITY LIPOPROTEIN LEVELS AND HEPATIC STEATOSIS IN PATIENTS WITH GENOTYPE 1 CHRONIC HEPATITIS C (CHC) SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Clark, Paul J.; Thompson, Alexander J.; Tillmann, Hans L.; Patel, Keyur; Naggie, Susanna; Muir, Andrew J.; McHutchison, John G.] Duke Clin Res Inst, Durham, NC USA. [Zhu, Mingfu; Zhu, Qianqian; Ge, Dongliang; Goldstein, David B.] Duke Univ, Inst Genome Sci & Policy, Ctr Human Genome Variat, Durham, NC USA. [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Afdhal, Nezam H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Jacobson, Ira M.] Weill Cornell Med Coll, New York, NY USA. [Esteban, Rafael] Hosp Gen Univ Valle Hebron, Barcelona, Spain. [Lawitz, Eric] Alamo Med Res, San Antonio, TX USA. [Poordad, Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Shiffman, Mitchell L.] Virginia Commonwealth Univ, Richmond, VA USA. [Galler, Greg Wayne] Kelsey Res Fdn, Houston, TX USA. [King, John W.] Louisiana State Univ, Shreveport, LA 71105 USA. [Harrison, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. [Kwo, Paul Y.] Indiana Univ Sch Med, Indianapolis, IN USA. [Nyberg, Lisa M.] Kaiser Permanente, San Diego, CA USA. [McCone, Jonathan] Mt Vernon Endoscopy Ctr, Alexandria, VA USA. [Lee, William M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Reindollar, Robert] Piedmont Healthcare, Statesville, NC USA. [Ghalib, Reem H.] Methodist Dallas Med Ctr, Liver Inst, Dallas, TX USA. [Freilich, Bradley] Kansas City Gastroenterol & Hepatol, Kansas City, MO USA. [Goodman, Zachary] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Boparai, Navdeep; Koury, Kenneth J.; Noviello, Stephanie; Pedicone, Lisa; Brass, Clifford A.; Albrecht, Janice K.] Merck & Co Inc, Whitehouse Stn, NJ USA. RI Zhu, Mingfu/F-3217-2011; Clark, Paul/A-1480-2012 OI Zhu, Mingfu/0000-0003-0296-712X; Clark, Paul/0000-0002-1821-4969 NR 0 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 232 BP 439A EP 440A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775600238 ER PT J AU Sulkowski, MS Harrison, SA Rossaro, L Hu, KQ Lawitz, E Shiffman, ML Muir, AJ Galler, GW McCone, J Nyberg, LM Lee, WM Ghalib, RH Long, JM Noviello, S Brass, CA Pedicone, L Albrecht, JK McHutchison, JG King, JW AF Sulkowski, Mark S. Harrison, Stephen A. Rossaro, Lorenzo Hu, Ke-Qin Lawitz, Eric Shiffman, Mitchell L. Muir, Andrew J. Galler, Greg Wayne McCone, Jonathan Nyberg, Lisa Marie Lee, William M. Ghalib, Reem H. Long, Jianmin Noviello, Stephanie Brass, Clifford A. Pedicone, Lisa Albrecht, Janice K. McHutchison, John G. King, John W. TI IMPAIRED FASTING GLUCOSE IS ASSOCIATED WITH LOWER RATES OF SUSTAINED VIROLOGIC RESPONSE (SVR) IN PATIENTS WITH GENOTYPE 1 CHRONIC HEPATITIS C (CHC): RETROSPECTIVE ANALYSIS OF THE IDEAL STUDY SO HEPATOLOGY LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 29-NOV 02, 2010 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Rossaro, Lorenzo] Univ Calif Davis, Sacramento Med Ctr UCDMC, Sacramento, CA 95817 USA. [Hu, Ke-Qin] Univ Calif Irvine, Med Ctr, Irvine, CA USA. [Lawitz, Eric] Alamo Med Res, San Antonio, TX USA. [Shiffman, Mitchell L.] Liver Inst Virginia, Newport News, VA USA. [Muir, Andrew J.; McHutchison, John G.] Duke Clin Res Inst, Durham, NC USA. [Galler, Greg Wayne] Kelsey Seybold Res Fdn, Houston, TX USA. [McCone, Jonathan] Mt Vernon Endoscopy Ctr, Alexandria, VA USA. [Nyberg, Lisa Marie] Kaiser Permanente, San Diego Med Ctr, San Diego, CA USA. [Lee, William M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Ghalib, Reem H.] Liver Inst Methodist Dallas, Dallas, TX USA. [Long, Jianmin; Noviello, Stephanie; Brass, Clifford A.; Pedicone, Lisa; Albrecht, Janice K.] Merck Res Labs, Kenilworth, NJ USA. [King, John W.] Louisiana State Univ, Hlth Sci Ctr, Shreveport, LA 71105 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2010 VL 52 IS 4 SU S MA 816 BP 712A EP 712A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 740EY UT WOS:000288775601136 ER PT J AU Rosen, MA Salas, E Pavlas, D Jensen, R Fu, D Lampton, D AF Rosen, Michael A. Salas, Eduardo Pavlas, Davin Jensen, Randy Fu, Dan Lampton, Donald TI Demonstration-Based Training: A Review of Instructional Features SO HUMAN FACTORS LA English DT Review DE training; observational learning; instructional design; demonstration-based training; demonstration; instructional systems ID SKILL ACQUISITION; MOTOR-SKILLS; BEHAVIOR; PERFORMANCE; REHEARSAL; ATTENTION; OUTCOMES; MEMORY; ERRORS; MODEL AB Objective: This article reviews instructional features used in demonstration-based training (DBT). Background: The need for fast and effective training and performance support that can be accessed from anywhere is a growing need for organizations. DBT programs are one method to address these needs, but a better understanding of how to maximize the effectiveness of DBT activities is needed. Specifically, beyond the content of the demonstration (i.e., the dynamic example of task performance), what instructional features (i.e., information and activities in addition to the demonstration) can be used to improve the effectiveness of DBT interventions? Method: The authors conducted a systematic review of the applied and basic science literatures relevant to DBT. Results: Instructional features in DBT can be categorized according to the degree to which they encourage active learner involvement (i.e., active vs. passive), when they occur relative to viewing the demonstration (i.e., pre-, during-, and postdemonstration conditions), and the observational learning process they are intended to augment. Five categories of instructional features are described: passive guidance or support, preparatory activities, concurrent activities, retrospective activities, and prospective activities. Conclusion: There is a wide variety of instructional features used in DBT, but more systematic research is needed to understand the conditions under which each is most effective as well as to outline a method for sequencing of demonstration with other delivery methods, such as practice opportunities. Application: The framework presented in this article can help guide the systematic development of training systems incorporating DBT as well as provide a direction for future research. C1 [Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32826 USA. [Jensen, Randy; Fu, Dan] Stottler Henke Associates Inc, San Mateo, CA USA. [Lampton, Donald] USA, Res Inst Behav & Social Sci, Orlando, FL USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM esalas@ist.ucf.edu FU U.S. Army Research Institute for the Behavioral and Social Sciences (ARI) [W91WAW-08-C-0020] FX This research was sponsored by the U.S. Army Research Institute for the Behavioral and Social Sciences (ARI), Contract No. W91WAW-08-C-0020. We are especially grateful to Donald Lampton and Bruce Knerr at ARI for initiating and contributing to the effort. NR 76 TC 16 Z9 16 U1 4 U2 19 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD OCT PY 2010 VL 52 IS 5 BP 596 EP 609 DI 10.1177/0018720810381071 PG 14 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 684XA UT WOS:000284587400005 PM 21186739 ER PT J AU Suri, N Benincasa, G Tortonesi, M Stefanelli, C Kovach, J Winkler, R Kohler, R Hanna, J Pochet, L Watson, S AF Suri, Niranjan Benincasa, Giacomo Tortonesi, Mauro Stefanelli, Cesare Kovach, Jesse Winkler, Robert Kohler, Ralph Hanna, James Pochet, Louis Watson, Scott TI Peer-to-Peer Communications for Tactical Environments: Observations, Requirements, and Experiences SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Tactical edge networks present extremely challenging environments for communications given their wireless ad hoc nature and the inherent node mobility. Military applications such as Blue Force Tracking, inter-team communications, remote unmanned vehicle control, and sensor data mining/fusion thus have to deal with unstable links with limited bandwidth and variable latency. The peculiar characteristics of tactical networks call for peer-to-peer approaches to realize complex, adaptive, and fault-tolerant applications to be deployed in the battlefield. This article reports on our observations from several tactical networking experiments in which we have deployed state-of-the-art applications and services that leverage P2P communications. More specifically, we discuss why P2P approaches are critical for tactical network environments and applications. We then analyze the requirements that should be satisfied by P2P middleware for tactical environments. Finally, we discuss a case study, the Agile Computing Middleware, and present experimental results that demonstrate its effectiveness. C1 [Tortonesi, Mauro; Stefanelli, Cesare] Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. [Kovach, Jesse] USA, Res Lab, Battlefield Informat Proc Branch, Washington, DC USA. [Kohler, Ralph; Hanna, James] USAF, Res Lab, Washington, DC USA. [Winkler, Robert] USA, Res Labs, Washington, DC USA. EM nsuri@ihmc.us; gbenincasa@ihmc.us; mauro.tortonesi@unife.it; cesare.stefanelli@unife.it; jkovach@arl.army.mil; winkler@arl.army.mil; Ralph.Kohler@rl.af.mil; james.hanna@rl.af.mil; loupochet@gmail.com; scott.c.watson@navy.mil OI Tortonesi, Mauro/0000-0002-7417-4455; Benincasa, Giacomo/0000-0002-6357-9043 FU U.S. Army Research Laboratory [W911NF-04-2-0013, DAAD19-01-2-0009]; Air Force Research Laboratory [FA8750-06-2-0064]; Office of Naval Research [N000140910012] FX This research was sponsored in part by the U.S. Army Research Laboratory under Cooperative Agreement W911NF-04-2-0013, by the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0009, by the Air Force Research Laboratory under Cooperative Agreement FA8750-06-2-0064, and by the Office of Naval Research under grant N000140910012. Figure 1 is courtesy of William Howell, Florida Institute for Human and Machine Cognition. NR 9 TC 16 Z9 16 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2010 VL 48 IS 10 BP 60 EP 69 DI 10.1109/MCOM.2010.5594678 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 669QM UT WOS:000283365300005 ER PT J AU Younis, O Kant, L McAuley, A Manousakis, K Shallcross, D Sinkar, K Chang, K Young, K Graff, C Patel, M AF Younis, Ossama Kant, Latha McAuley, Anthony Manousakis, Kyriakos Shallcross, David Sinkar, Kaustubh Chang, Kirk Young, Kenneth Graff, Charles Patel, Mitesh TI Cognitive Tactical Network Models SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Unlike commercial MANET applications, tactical networks are typically hierarchical and involve heterogeneous types of radio communications. Future tactical networks also require cognitive functions across the protocol stack to exploit scarce spectrum and dynamically adapt functions and configuration settings. In this work we highlight the need for novel design tools for cognitive tactical networks. We define a system design model that will provide the foundation for generic network design problem formulations via the use of cognitive techniques covering both dynamic frequency adaptations and machine-learning-related aspects of cognition. We use the system model to identify several potential cognitive design knobs and describe how the different design knobs can potentially be adjusted at different timescales of operation. These knobs are used in formulating a cognitive network design problem. Finally, we discuss how a network designer can potentially benefit from the proposed model result, a cognitive network design toolset we have recently developed. C1 [Graff, Charles] USA, CERDEC, RDECOM, Ft Monmouth, NJ USA. [Patel, Mitesh] USA, CERDEC, Aberdeen Proving Ground, MD USA. NR 9 TC 10 Z9 10 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2010 VL 48 IS 10 BP 70 EP 77 DI 10.1109/MCOM.2010.5594679 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 669QM UT WOS:000283365300006 ER PT J AU Wasikowski, M Chen, XW AF Wasikowski, Mike Chen, Xue-wen TI Combating the Small Sample Class Imbalance Problem Using Feature Selection SO IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING LA English DT Article DE Class imbalance problem; feature evaluation and selection; machine learning; pattern recognition; bioinformatics; text mining ID MUTUAL INFORMATION; CLASSIFICATION; REDUNDANCY; RELEVANCE; CANCER AB The class imbalance problem is encountered in real-world applications of machine learning and results in a classifier's suboptimal performance. Researchers have rigorously studied the resampling, algorithms, and feature selection approaches to this problem. No systematic studies have been conducted to understand how well these methods combat the class imbalance problem and which of these methods best manage the different challenges posed by imbalanced data sets. In particular, feature selection has rarely been studied outside of text classification problems. Additionally, no studies have looked at the additional problem of learning from small samples. This paper presents a first systematic comparison of the three types of methods developed for imbalanced data classification problems and of seven feature selection metrics evaluated on small sample data sets from different applications. We evaluated the performance of these metrics using area under the receiver operating characteristic (AUC) and area under the precision-recall curve (PRC). We compared each metric on the average performance across all problems and on the likelihood of a metric yielding the best performance on a specific problem. We examined the performance of these metrics inside each problem domain. Finally, we evaluated the efficacy of these metrics to see which perform best across algorithms. Our results showed that signal-to-noise correlation coefficient (S2N) and Feature Assessment by Sliding Thresholds (FAST) are great candidates for feature selection in most applications, especially when selecting very small numbers of features. C1 [Wasikowski, Mike] USA, Methods & Res Off, Training & Doctrine Command Anal Ctr, Ft Leavenworth, KS 66027 USA. [Chen, Xue-wen] Univ Kansas, Dept Elect Engn & Comp Sci, Lawrence, KS 66045 USA. RP Wasikowski, M (reprint author), USA, Methods & Res Off, Training & Doctrine Command Anal Ctr, 255 Sedgwick Ave, Ft Leavenworth, KS 66027 USA. EM mike.wasikowski@us.army.mil; xwchen@ku.edu FU US National Science Foundation [IIS-0644366] FX This work is supported by the US National Science Foundation Award IIS-0644366. The authors would like to thank Oscar Luaces for his assistance in compiling the MEX interfaces for SV Mperf. NR 59 TC 75 Z9 80 U1 5 U2 48 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1041-4347 J9 IEEE T KNOWL DATA EN JI IEEE Trans. Knowl. Data Eng. PD OCT PY 2010 VL 22 IS 10 BP 1388 EP 1400 DI 10.1109/TKDE.2009.187 PG 13 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 639UQ UT WOS:000281000500004 ER PT J AU Curry, RD Altgilbers, L Jiang, WH Smith, PW AF Curry, Randy D. Altgilbers, Larry Jiang, Weihua Smith, Paul W. TI Special Issue on Pulsed Power Science and Technology SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Editorial Material C1 [Curry, Randy D.] Univ Missouri, Columbia, MO 65211 USA. [Altgilbers, Larry] USA, Space & Missile Def Command, Huntsville, AL 35807 USA. [Jiang, Weihua] Nagaoka Univ Technol, Extreme Energy Dens Res Inst, Niigata 9402188, Japan. [Smith, Paul W.] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England. RP Curry, RD (reprint author), Univ Missouri, Columbia, MO 65211 USA. EM curryrd@missouri.edu; Larry.Altgilbers@smdc.army.mil; jiang@nagaokaut.ac.jp; paul.smith@eng.ox.ac.uk NR 0 TC 0 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2010 VL 38 IS 10 BP 2506 EP 2506 DI 10.1109/TPS.2010.2079533 PN 1 PG 1 WC Physics, Fluids & Plasmas SC Physics GA 670LE UT WOS:000283422400001 ER PT J AU Zhang, W Ma, XL Swami, A AF Zhang, Wei Ma, Xiaoli Swami, Ananthram TI Designing Low-Complexity Detectors Based on Seysen's Algorithm SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE Linear equalizers; soft-output detectors; tree-search; lattice reduction; complexity ID LATTICE-REDUCTION; OFDM; SYSTEMS AB Lattice reduction (LR) has been applied to linear equalizers and decision feedback equalizers to improve their performance. Recently, Seysen's algorithm (SA) has been proposed as an alternative LR method to the well-documented LLL algorithm. In this paper, we first provide a tree-search implementation method of SA which enables flexible performance-complexity trade-offs. Based on this tree structure, SA-aided hard-output and soft-output detectors are proposed to enhance performance. The diversity and complexity of the proposed methods are also studied. Thorough comparisons of SA and other LR algorithms are provided. Our analysis of complexity and numerical simulations provide insights that are useful to system designers. C1 [Zhang, Wei; Ma, Xiaoli] Georgia Inst Technol, Sch Elect & Comp Eng, Atlanta, GA 30332 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, W (reprint author), Qualcomm CDMA Technol, Santa Clara, CA 95051 USA. EM weizhang@qualcomm.com; xiaoli@ece.gatech.edu; a.swami@ieee.org FU U.S. Army Research Laboratory [DAAD19-01-2-0011]; U.S. Army Research Office [W911NF-06-1-0090] FX This material is based on work supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under grant no. W911NF-06-1-0090 and thorough collaborative participation in the Collaborative Technology Alliance for Communications & Networks sponsored by the U. S. Army Research Laboratory under Cooperative Agreement DAAD19-01-2-0011. NR 28 TC 7 Z9 8 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD OCT PY 2010 VL 9 IS 10 BP 3301 EP 3311 DI 10.1109/TWC.2010.081610.100659 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 670OP UT WOS:000283436800035 ER PT J AU Dong, J Zaghloul, AI AF Dong, J. Zaghloul, A. I. TI Extremely high-frequency beam steerable lens-fed antenna for vehicular sensor applications SO IET MICROWAVES ANTENNAS & PROPAGATION LA English DT Article; Proceedings Paper CT 20th Asia Pacific Microwave Conference CY DEC 19-20, 2008 CL Macau, PEOPLES R CHINA ID ROTMAN LENSES AB A low-profile, high-performance beam steerable antenna, also referred to as electrically steerable array or array, system is proposed for vehicular sensor applications. The antenna aperture is realised by a phased array fed with a tri-focal Rotman lens. Theory of designing the beam-forming network and an improved parametric study are presented, while the narrow-H-plane, broad-E-plane microstrip antenna fed by the printed lens is investigated for extremely high-frequency -band operation. The full wave simulation demonstrates good results for the antenna use over the required two-dimensional scanning range of +45 degrees. C1 [Dong, J.; Zaghloul, A. I.] Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. [Dong, J.] Microwave Engn Corp, N Andover, MA 01845 USA. [Zaghloul, A. I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Dong, J (reprint author), Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. EM junweid@gmail.com NR 23 TC 4 Z9 4 U1 0 U2 2 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8725 J9 IET MICROW ANTENNA P JI IET Microw. Antennas Propag. PD OCT PY 2010 VL 4 IS 10 BP 1549 EP 1558 DI 10.1049/iet-map.2009.0271 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 668CV UT WOS:000283247100016 ER PT J AU Chen, WH Basu, S Bhattacharjee, AK Cross, AS AF Chen, Wilbur H. Basu, Subhendu Bhattacharjee, Apurba K. Cross, Alan S. TI Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors SO INNATE IMMUNITY LA English DT Article DE antibody; cytokine; endotoxin vaccine; Toll-like receptor (TLR); synergy ID ESCHERICHIA-COLI J5; GRAM-NEGATIVE BACTEREMIA; COMPLEX VACCINE; DENDRITIC CELLS; ACTIVE IMMUNIZATION; CYTOKINE PRODUCTION; IMMUNE-RESPONSES; BACTERIAL-DNA; SEPTIC SHOCK; DOUBLE-BLIND AB When given passively or elicited actively, antibodies induced by a detoxified Escherichia coli Rc chemotype (J5) mutant lipopolysaccharide (J5dLPS)-group B meningococcal outer membrane protein (OMP) complex vaccine protected animals from lethal sepsis. The protection from sepsis is believed to be dependent on high levels of antibodies against the core glycolipid (CGL), a region of LPS that is rather conserved among Enterobacteriaceae. The addition of unmethylated deoxycytidyl-deoxyguanosine dinucleotide (CpG)-containing oligodeoxynucleotides (ODN) was used as an immuno-adjuvant to improve antibody responses. In preparation for a Phase I human trial, we elucidated potential contributions by which the sepsis vaccine (J5dLPS-OMP) and CpG ODN might enhance the antibody response and provide evidence that the generation of immune responses is Toll-like receptor (TLR) dependent. Toll-like receptor 2, TLR4, and TLR9 were each essential for generating robust cytokine and antibody responses. The signature cytokine of dendritic cells, interleukin-12, was one of the cytokines that demonstrated synergy with the optimal TLR ligand/ engagement combination. We conclude that the involvement of multiple TLRs upon immunization was critical for the generation of optimal antibody responses. These observations provide further evidence for the inclusion of innate immune-based adjuvants during the development of next-generation vaccines. C1 [Chen, Wilbur H.; Basu, Subhendu; Cross, Alan S.] Univ Maryland, Ctr Vaccine Dev, Sch Med, Baltimore, MD 21201 USA. [Bhattacharjee, Apurba K.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Chen, WH (reprint author), Univ Maryland, Ctr Vaccine Dev, Sch Med, 685 W Baltimore St,HSF 1,Suite 480, Baltimore, MD 21201 USA. EM wchen@medicine.umaryland.edu FU National Institute of Allergy and Infectious Diseases [RO1AI 42181, T32AI07524]; National Center for Research Resources [K12RR023250] FX This research was supported by National Institute of Allergy and Infectious Diseases grants RO1AI 42181 and T32AI07524 and National Center for Research Resources grant K12RR023250 (WHC). NR 35 TC 6 Z9 6 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1753-4259 J9 INNATE IMMUN-LONDON JI Innate Immun. PD OCT PY 2010 VL 16 IS 5 BP 322 EP 332 DI 10.1177/1753425909346973 PG 11 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA 653LG UT WOS:000282092200006 PM 19822632 ER PT J AU Lee, BB Andrade, M Bergan, J Boccardo, F Campisi, C Damstra, R Flour, M Gloviczki, P Laredo, J Piller, N Michelini, S Mortimer, P Villavicencio, JL AF Lee, B. B. Andrade, M. Bergan, J. Boccardo, F. Campisi, C. Damstra, R. Flour, M. Gloviczki, P. Laredo, J. Piller, N. Michelini, S. Mortimer, P. Villavicencio, J. L. TI Diagnosis and treatment of primary lymphedema. Consensus Document of the International Union of Phlebology (IUP)-2009 SO INTERNATIONAL ANGIOLOGY LA English DT Article DE Lymphedema; Lymphatic abnormalities; Drainage; Reconstructive surgical procedures ID CONGENITAL VASCULAR MALFORMATIONS; KLIPPEL-TRENAUNAY-SYNDROME; ARTERIOVENOUS SHUNTING MALFORMATION; LYMPHO-VENOUS ANASTOMOSES; CANCER-RELATED LYMPHEDEMA; COMPLEX PHYSICAL-THERAPY; REDUCES ARM LYMPHEDEMA; PORT-WINE STAINS; PERIPHERAL LYMPHEDEMA; ADVANCED MANAGEMENT AB Primary lymphedema can be managed safely as one of the chronic lymphedemas by a proper combination of DLT with compression therapy. Treatment in the maintenance phase should include compression garments, self management including the compression therapy, self massage and meticulous personal hygiene and skin care in addition to lymph-transport promoting excercises. The management of primary lymphedema can be further improved with proper addition of surgical therapy either reconstructive or ablative. These two surgical therapies can be effective only when fully integrated with MLD-based DLT postoperatively. Compliance with a long-term commitment of DLT postoperatively is the most critical factor determining the success of any new treatment strategy with either reconstructive or palliative surgery. The future of management of primary lymphedema caused by truncular lymphatic malformation has never been brighter with the new prospect of gene-oriented management. [Int Angiol 2010;29:454-70] C1 [Lee, B. B.; Laredo, J.] Georgetown Univ, Sch Med, Ctr Vein Lymphat & Vasc Malformat, Div Vasc Surg,Dept Surg, Washington, DC 20057 USA. [Andrade, M.] Univ Sao Paulo, Sch Med, Dept Surg, Sao Paulo, Brazil. [Bergan, J.] Univ Calif San Diego, Dept Surg, UCSD Sch Med, San Diego, CA 92103 USA. [Boccardo, F.; Campisi, C.] Univ Genoa, Sect Lymphol & Microsurg, Univ Hosp S Martino, Dept Surg,Unit Lymphat Surg, Genoa, Italy. [Damstra, R.] Nij Smellinghe Hosp, Dept Dermatol & Phlebol & Lympho Vasc Med, Drachten, Netherlands. [Flour, M.] Univ Hosp Leuven, Multidisciplinary Diabet Foot Clin, Vasc Ctr, Dept Dermatol, Louvain, Belgium. [Gloviczki, P.] Mayo Clin, Div Vasc & Endovasc Surg, Rochester, MN USA. [Gloviczki, P.] Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA. [Piller, N.] Flinders Univ S Australia, Sch Med, Dept Surg, Lymphoedema Assessment Clin, Adelaide, SA, Australia. [Michelini, S.] San Giovanni Battista Hosp, Dept Vasc Rehabil, Rome, Italy. [Mortimer, P.] St Georges Univ London, London, England. [Villavicencio, J. L.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Surg, Bethesda, MD USA. [Villavicencio, J. L.] Walter Reed Army Med Ctr, Venous & Lymphat Teaching Clin, Bethesda, MD USA. RP Lee, BB (reprint author), Georgetown Univ, Sch Med, Ctr Vein Lymphat & Vasc Malformat, Div Vasc Surg,Dept Surg, Washington, DC 20057 USA. EM bblee38@comcast.net NR 145 TC 39 Z9 40 U1 2 U2 8 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 J9 INT ANGIOL JI Int. Angiol. PD OCT PY 2010 VL 29 IS 5 BP 454 EP 470 PG 17 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 711AS UT WOS:000286558700013 PM 20924350 ER PT J AU Nilakantan, G Keefe, M Bogetti, TA Gillespie, JW AF Nilakantan, Gaurav Keefe, Michael Bogetti, Travis A. Gillespie, John W., Jr. TI Multiscale modeling of the impact of textile fabrics based on hybrid element analysis SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Textile composite; Woven fabric; Finite element analysis (FEA); Impact; Multi scale modeling ID BALLISTIC IMPACT; SIMULATION; FRICTION; BEHAVIOR; ARMOR AB In this work, a multi scale modeling approach has been developed to simulate the impact of woven fabrics using a finite element (FE) analysis. A yarn level of resolution is used in the model. This approach, referred to as the hybrid element analysis (HEA) is based on decreasing the complexity of the finite element model with distance away from the impact zone based on the multiscale nature of the fabric architecture and the physics of the impact event. Solid elements are used to discretize the yarns around the impact region, which transition to shell elements in the surrounding region. A new method for modeling the shell yarns is incorporated that more accurately represents the contours of the yarn cross section. Impedances have been matched across the solid shell interface to prevent interfacial reflections of the longitudinal strain wave. The HEA method is validated by first applying it to the FE model of a single yarn for which an analytical solution is known. The HEA method is then applied to a woven fabric model and validated by comparing it against a baseline model consisting of yarns discretized using only solid elements. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Nilakantan, Gaurav; Keefe, Michael; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Nilakantan, Gaurav; Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gillespi@udel.edu RI Nilakantan, Gaurav/B-8643-2012 OI Nilakantan, Gaurav/0000-0002-5375-9681 FU US Army Research Laboratory at the Aberdeen Proving Ground, MD, USA through University of Delaware, Center for Composite Materials FX This work was supported by the US Army Research Laboratory at the Aberdeen Proving Ground, MD, USA through the Composite Materials Research (CMR) program at the University of Delaware, Center for Composite Materials. NR 22 TC 27 Z9 29 U1 1 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT PY 2010 VL 37 IS 10 BP 1056 EP 1071 DI 10.1016/j.ijimpeng.2010.04.007 PG 16 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 631XE UT WOS:000280383200006 ER PT J AU Mancuso, JD Tobler, SK Eick, AA Olsen, CH AF Mancuso, J. D. Tobler, S. K. Eick, A. A. Olsen, C. H. TI An evaluation of the completeness and accuracy of active tuberculosis reporting in the United States military SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE tuberculosis; surveillance evaluation; military medicine; capture-recapture ID CAPTURE-RECAPTURE METHODS; US-ARMY; SURVEILLANCE; INFECTION; NAVY; TIMELINESS; PERSONNEL; OUTBREAK; RATES AB SETTING: Despite the low incidence of tuberculosis (TB) in the United States military, there is uncertainty in the overall reporting and estimates of incidence. OBJECTIVE: To assess TB reporting in the active component US military. DESIGN: TB notification in the US military was compared with three other data sources: laboratory, hospitalization and pharmacy records. Sensitivity and positive predictive value were estimated for all data sources using a gold standard of either a reportable medical event (RME) reported as confirmed or a positive laboratory result for Mycobacterium tuberculosis. Uncorrected and capture-recapture (CR) methods were used to estimate underreporting and completeness of data sources. RESULTS: Completeness of reporting of pulmonary TB cases was estimated as 72.4% uncorrected or 58.3% with CR. Even after correction for possible underreporting, the incidence of active pulmonary TB was only 0.87 per 100000 person-years between 2004 and 2006. CONCLUSION: The rate of active TB in the US military is low. Like civilian surveillance, US military RME surveillance may substantially underreport TB incidence rates. Expanding surveillance to include data sources such as hospitalizations and pharmacy records will increase the number of TB diagnoses at the cost of including many false-positives. C1 [Mancuso, J. D.] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA. [Mancuso, J. D.; Olsen, C. H.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Tobler, S. K.; Eick, A. A.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil NR 32 TC 3 Z9 3 U1 0 U2 0 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD OCT PY 2010 VL 14 IS 10 BP 1310 EP 1315 PG 6 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA 661FR UT WOS:000282710700014 PM 20843423 ER PT J AU Mathew, SD Bristow, K Higgs, J AF Mathew, Stephanie D. Bristow, Kelly Higgs, Jay TI Giant Cell Arteritis Presenting as Ageusia and Lower Extremity Claudication SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article ID RHEUMATOLOGY 1990 CRITERIA; FOLLOW-UP; CLASSIFICATION C1 [Mathew, Stephanie D.; Higgs, Jay] USAF, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Bristow, Kelly] USAF, Wilford Hall Med Ctr, Lackland AFB, TX USA. RP Mathew, SD (reprint author), USAF, Brooke Army Med Ctr, 3750 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephanie.Mathew@amedd.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD OCT PY 2010 VL 16 IS 7 BP 343 EP 344 DI 10.1097/RHU.0b013e3181f4e100 PG 2 WC Rheumatology SC Rheumatology GA 658SA UT WOS:000282508500011 PM 20859219 ER PT J AU Pollard, KA Blumstein, DT Griffin, SC AF Pollard, Kimberly A. Blumstein, Daniel T. Griffin, Suzanne C. TI Pre-screening acoustic and other natural signatures for use in noninvasive individual identification SO JOURNAL OF APPLIED ECOLOGY LA English DT Article DE censusing; individuality; individual discrimination; information theory; marking; signature; vocalization ID VOCAL INDIVIDUALITY; CONSERVATION TOOL; VOCALIZATIONS; RECOGNITION; PATTERNS; OWLS; DISCRIMINATION; CONSEQUENCES; INFORMATION; MANAGEMENT AB P>1. Common ecological tasks, such as wildlife monitoring, adaptive management, and behavioural study, often make use of natural signatures (e.g. animal calls or visual markings) to identify individual animals noninvasively. However, there is no accepted method for pre-screening candidate natural signatures to select which signatures are the best-suited for this purpose. In this paper, we suggest a pre-screening checklist and focus on the challenge of assessing a candidate signature's individuality. 2. Individuality is critical, as the use of low-individuality natural signatures can lead to misidentification of individuals and therefore bias estimation of population parameters and population response to management actions. An information-based metric of individuality could assist researchers with selecting suitable signatures by allowing comparison among candidate signatures and providing an estimate of how many individuals may be reliably discriminated using a particular signature. 3. Before an individuality metric can be used to pre-screen natural signatures, the metric must first be calculated from preliminary sampling and must be robust to typical sampling concerns. We used field-collected animal vocalizations as well as simulations to test how robust the metric is to variation in sampling design. 4. We found that the metric is fairly robust to the number of animals sampled and the number of sessions (e.g. calling bouts) analysed, but that it is sensitive to the number of observations per session. 5. Synthesis and applications. Managers and researchers could save time and energy and improve the accuracy of estimates (such as abundance, survival, or population response) based on individual identification by first pre-screening candidate natural signatures for their individuality. As long as the number of observations per session is controlled, the relative values of the individuality metric can be meaningfully compared. The metric can thus be used as a tool to estimate relative individuality and so facilitates a difficult step in choosing a natural signature for noninvasive individual identification. We include instructions on how to calculate and interpret the individuality metric. C1 [Pollard, Kimberly A.; Blumstein, Daniel T.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA. [Griffin, Suzanne C.] Univ Montana, Dept Ecosyst Conservat, Missoula, MT 59812 USA. RP Pollard, KA (reprint author), USA, Res Lab, Human Res & Engn Directorate, Visual & Auditory Proc Branch, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM kpollard@ucla.edu RI Blumstein, Daniel/B-6199-2012; OI Blumstein, Daniel/0000-0001-5793-9244 FU American Philosophical Society; American Society of Mammalogists; Animal Behavior Society; Explorers Club; Mildred Mathias/UC Reserves; National Science Foundation (GRFP); Sigma Xi; George Bartholomew Research Fellowship; Holmes O. Miller Fellowship; UCLA; National Science Foundation [DEB-0415604, DEB-0415932]; Canon National Park; NSERC FX We thank J. Hare for providing recordings of Richardson's ground squirrels, S. Pagacz and J. Witczuk for help collecting Olympic marmot recordings, and N. Beri, D. Farsakh, N. Mahoney, A. Satoh, Y. Sharma, E. Tanaka, and A. Thu Tran for help measuring the recorded calls in the lab. We thank R. Mundry for helpful suggestions on macro construction and P. Nonacs, J. Silk, J. Hare, G. Grether, and P. Griffin for comments on previous versions of this manuscript. We thank Olympic National Park, B. Wrigley, and the Assiniboine Park Zoo staff for recording access. K.A.P.'s work on individuality has been supported by the American Philosophical Society, American Society of Mammalogists, Animal Behavior Society, Explorers Club, Mildred Mathias/UC Reserves, National Science Foundation (GRFP), Sigma Xi, George Bartholomew Research Fellowship, Holmes O. Miller Fellowship, and UCLA Quality of Graduate Education Fellowship. S.C.G.'s work was supported by the National Science Foundation (grants DEB-0415604, DEB-0415932, and a graduate student fellowship) and the Canon National Parks Science Scholars Program. J. Hare's work was supported by an NSERC Discovery Grant. Trapping and handling procedures were approved by the Canadian Council on Animal Care and the Animal Care and Use Committees of UCLA, the University of Montana, and the University of Manitoba. NR 51 TC 11 Z9 11 U1 0 U2 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-8901 J9 J APPL ECOL JI J. Appl. Ecol. PD OCT PY 2010 VL 47 IS 5 BP 1103 EP 1109 DI 10.1111/j.1365-2664.2010.01851.x PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 643HS UT WOS:000281286800016 ER PT J AU Mal, S Nori, S Jin, CM Narayan, J Nellutla, S Smirnov, AI Prater, JT AF Mal, Siddhartha Nori, Sudhakar Jin, Chunming Narayan, J. Nellutla, S. Smirnov, A. I. Prater, J. T. TI Reversible room temperature ferromagnetism in undoped zinc oxide: Correlation between defects and physical properties SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRON-PARAMAGNETIC RESONANCE; D(0) FERROMAGNETISM; IRRADIATED ZNO; POINT-DEFECTS; THIN-FILMS; DOPED ZNO; SEMICONDUCTORS; VACANCIES; PHOTOLUMINESCENCE; 1ST-PRINCIPLES AB We report a systematic study of the structural, chemical, electrical, optical, and magnetic properties of undoped ZnO thin films grown under different conditions as well as the films that were annealed in various environments. Oxygen-annealed films displayed a sequential transition from ferromagnetism to diamagnetism as a function of the annealing temperature. An increase in the green band intensity has been observed in oxygen-annealed ZnO films. Reversible switching of room-temperature ferromagnetism and n-type conductivity have been demonstrated by oxygen and vacuum annealing. Electron paramagnetic resonance data were found to be in agreement with the results of magnetization and conductivity measurements. Possibility of external ferromagnetic impurity as the origin of the unconventional room temperature ferromagnetism in these films has been ruled out by secondary ion mass spectrometer and electron energy loss spectroscopy studies. Correlation between structural, electrical, optical, and magnetic properties has been established in terms of defects and defect complexes. Taken together, our data indicate that the ferromagnetic order in ZnO matrix might be defect-mediated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3491037] C1 [Mal, Siddhartha; Nori, Sudhakar; Jin, Chunming; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Nellutla, S.; Smirnov, A. I.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. [Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. EM smal@ncsu.edu RI Nori, Sudhakar/E-8111-2010; Smirnov, Alex/Q-9818-2016 OI Smirnov, Alex/0000-0002-0037-2555 FU Army Research Office [W911NF-04-D-0003]; National Science Foundation [NSF 0653722]; U.S. Department of Energy [DE-FG02-02ER15354] FX The authors are pleased to acknowledge the support of the Army Research Office under grant W911NF-04-D-0003, the National Science Foundation under Grant No. NSF 0653722, and a partial support from the U.S. Department of Energy under Contract No. DE-FG02-02ER15354 to AIS. NR 61 TC 43 Z9 43 U1 0 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2010 VL 108 IS 7 AR 073510 DI 10.1063/1.3491037 PG 10 WC Physics, Applied SC Physics GA 667UW UT WOS:000283222200034 ER PT J AU Sablon, KA Little, JW Olver, KA Wang, ZM Dorogan, VG Mazur, YI Salamo, GJ Towner, FJ AF Sablon, K. A. Little, J. W. Olver, K. A. Wang, Zh. M. Dorogan, V. G. Mazur, Yu. I. Salamo, G. J. Towner, F. J. TI Effects of AlGaAs energy barriers on InAs/GaAs quantum dot solar cells SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID OPTICAL-PROPERTIES AB We have studied the effects of AlGaAs energy barriers surrounding self-assembled InAs quantum dots in a GaAs matrix on the properties of solar cells made with multiple quantum dot layers in the active region of a photodiode. We have compared the fenced dot samples with conventional InAs/GaAs quantum dot solar cells and with GaAs reference cells. We have found that, contrary to theoretical predictions, the AlGaAs fence layers do not enhance the transport properties of photogenerated carriers but instead suppress the extraction of the carriers excited in the dots by light with wavelengths longer than the cutoff wavelength of the GaAs matrix material. Both the standard quantum dots and the fenced dots were found to give solar cell performance comparable to the GaAs reference cells for certain active region thicknesses but neither showed enhancement due to the longer wavelength absorption or improved carrier transport. (C) 2010 American Institute of Physics. [doi:10.1063/1.3486014] C1 [Sablon, K. A.; Little, J. W.; Olver, K. A.] USA, Res Lab, Adelphi, MD 20783 USA. [Wang, Zh. M.; Dorogan, V. G.; Mazur, Yu. I.; Salamo, G. J.] Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA. [Towner, F. J.] Max Technol Inc, College Pk, MD 20740 USA. RP Sablon, KA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM k.sablonramsey@us.army.mil RI Dorogan, Vitaliy/D-7019-2012; Wang, Zhiming/Q-1031-2015 NR 12 TC 16 Z9 16 U1 1 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2010 VL 108 IS 7 AR 074305 DI 10.1063/1.3486014 PG 4 WC Physics, Applied SC Physics GA 667UW UT WOS:000283222200121 ER PT J AU Lorenzo, S Halliwill, JR Sawka, MN Minson, CT AF Lorenzo, Santiago Halliwill, John R. Sawka, Michael N. Minson, Christopher T. TI Heat acclimation improves exercise performance SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE maximal oxygen uptake; time-trial performance; lactate threshold; plasma volume; cardiac output; hot environment; cool environment ID PLASMA-VOLUME EXPANSION; MAXIMAL AEROBIC POWER; BLOOD-VOLUME; MUSCLE METABOLISM; RAT-HEART; STRESS; MEN; FLOW; TEMPERATURE; ENVIRONMENT AB This study examined the impact of heat acclimation on improving exercise performance in cool and hot environments. Twelve trained cyclists performed tests of maximal aerobic power ((V) over dotO(2max))(,) time-trial performance, and lactate threshold, in both cool [13 degrees C, 30% relative humidity (RH)] and hot (38 degrees C, 30% RH) environments before and after a 10-day heat acclimation (similar to 50% (V) over dotO(2max) in 40 degrees C) program. The hot and cool condition (V) over dotO(2max) and lactate threshold tests were both preceded by either warm (41 degrees C) water or thermoneutral (34 degrees C) water immersion to induce hyperthermia (0.8-1.0 degrees C) or sustain normothermia, respectively. Eight matched control subjects completed the same exercise tests in the same environments before and after 10 days of identical exercise in a cool (13 degrees C) environment. Heat acclimation increased (V) over dotO(2max) by 5% in cool (66.8 +/- 2.1 vs. 70.2 +/- 2.3 ml.kg(-1).min(-1), P = 0.004) and by 8% in hot (55.1 +/- 2.5 vs. 59.6 +/- 2.0 ml.kg(-1).min(-1), P = 0.007) conditions. Heat acclimation improved time-trial performance by 6% in cool (879.8 +/- 48.5 vs. 934.7 +/- 50.9 kJ, P = 0.005) and by 8% in hot (718.7 +/- 42.3 vs. 776.2 +/- 50.9 kJ, P = 0.014) conditions. Heat acclimation increased power output at lactate threshold by 5% in cool (3.88 +/- 0.82 vs. 4.09 +/- 0.76 W/kg, P = 0.002) and by 5% in hot (3.45 +/- 0.80 vs. 3.60 +/- 0.79 W/kg, P < 0.001) conditions. Heat acclimation increased plasma volume (6.5 +/- 1.5%) and maximal cardiac output in cool and hot conditions (9.1 +/- 3.4% and 4.5 +/- 4.6%, respectively). The control group had no changes in (V) over dotO(2max), time-trial performance, lactate threshold, or any physiological parameters. These data demonstrate that heat acclimation improves aerobic exercise performance in temperate-cool conditions and provide the scientific basis for employing heat acclimation to augment physical training programs. C1 [Lorenzo, Santiago; Halliwill, John R.; Minson, Christopher T.] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA. [Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Minson, CT (reprint author), Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA. EM minson@uoregon.edu FU Clarissa and Evonuk Memorial Fellowship; National Institutes of Health [HL-081671] FX Funding of this research project was provided by the Clarissa and Evonuk Memorial Fellowship and National Institutes of Health Grant HL-081671 (Minson). NR 42 TC 94 Z9 97 U1 6 U2 51 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 2010 VL 109 IS 4 BP 1140 EP 1147 DI 10.1152/japplphysiol.00495.2010 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 695BF UT WOS:000285344900027 PM 20724560 ER PT J AU Fonda, SJ Kedziora, RJ Vigersky, RA Bursell, SE AF Fonda, Stephanie J. Kedziora, Richard J. Vigersky, Robert A. Bursell, Sven-Erik TI Evolution of a web-based, prototype Personal Health Application for diabetes self-management SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE Diabetes; Internet; Self-management; Telemedicine ID GLYCEMIC CONTROL; UNITED-STATES; COMPLICATIONS; FREQUENCY; MELLITUS; QUALITY; ADULTS; CARE; RISK AB Behaviors carried out by the person with diabetes (e. g., healthy eating, physical activity, judicious use of medication, glucose monitoring, coping and problem-solving, regular clinic visits, etc.) are of central importance in diabetes management. To assist with these behaviors, we developed a prototype PHA for diabetes self-management that was based on User-Centered Design principles and congruent with the anticipatory vision of Project Health Design (PHD). This article presents aspects of the prototype PHA's functionality as conceived under PHD and describes modifications to the PHA now being undertaken under new sponsorship, in response to user feedback and timing tests we have performed. In brief, the prototype Personal Health Application (PHA) receives data on the major diabetes management domains from a Personal Health Record (PHR) and analyzes and provides feedback based on clinically vetted educational content. The information is presented within "gadgets" within a portal-based website. The PHR used for the first implementation was the Common Platform developed by PHD. Key changes include a re-conceptualization of the gadgets by topic areas originally defined by the American Association of Diabetes Educators, a refocusing on low-cost approaches to diabetes monitoring and data entry, and synchronization with a new PHR, Microsoft (R) HealthVault (TM). (C) 2010 Elsevier Inc. All rights reserved. C1 [Fonda, Stephanie J.; Vigersky, Robert A.] Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, Washington, DC 20307 USA. [Kedziora, Richard J.] Estenda Solut Inc, Conshohocken, PA USA. [Bursell, Sven-Erik] Univ Hawaii, John A Burns Sch Med, Telehlth Res Inst, Honolulu, HI 96822 USA. RP Fonda, SJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, 6900 Georgia Ave NW,Bldg 2,Room 7D08, Washington, DC 20307 USA. EM fondasj@gmail.com FU Robert Wood Johnson Foundation [59888, 63415, 64533]; California HealthCare Foundation; U.S. Army Medical Research and Materiel Command [W81XWH-09-2-0196] FX This work was supported by Grant 59888 (Fonda and Bursell) and Grants 63415 and 64533 (Fonda) from the Robert Wood Johnson Foundation and the California HealthCare Foundation. Refinement of the work under the first grants has been supported by Grant W81XWH-09-2-0196 from U.S. Army Medical Research and Materiel Command (Fonda). NR 18 TC 9 Z9 9 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 J9 J BIOMED INFORM JI J. Biomed. Inform. PD OCT PY 2010 VL 43 IS 5 SU 1 BP S17 EP S21 DI 10.1016/j.jbi.2010.05.006 PG 5 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA 804WZ UT WOS:000293686500006 PM 20937479 ER PT J AU Lakshmi, TSR Shanmugasundaram, N Shanmuganathan, S Karthikeyan, K Meenakshi, J Babu, M AF Lakshmi, T. S. Ramyaa Shanmugasundaram, N. Shanmuganathan, S. Karthikeyan, K. Meenakshi, J. Babu, Mary TI Controlled release of 2, 3 desulfated heparin exerts its anti-inflammatory activity by effectively inhibiting E-selectin SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE heparin; desulfation; inflammation; microspheres; controlled release ID ENDOTHELIAL-CELLS; IN-VITRO; CHITOSAN MICROSPHERES; MOLECULAR-WEIGHT; ADHESION; DELIVERY; PROLIFERATION; BURNS; MICE AB Control of inflammation using appropriate antiinflammatory agent prevents wound from becoming chronic. Heparin is a heterogeneous mixture of polysaccharide molecules with a mean molecular weight between 12-30 kDa containing 200-300 disaccharide units of glycosaminoglycan chains. Chemical modifications leading to generation of a unique pentasaccharide sequence effectively reduces its anticoagualant activity, while retaining its anti-inflammmatory property. In this study, Standard heparin was partially desulfated to 2, 3 desulfated heparin (2, 3 DSH) and its anti-inflammatory property was determined by assessing its ability to prevent static adhesion of leukocytes to endothelium and clotting assay. The effectiveness of 2, 3 DSH to down regulate E-selectin and key proinflammatory cytokines (IL-1 beta and IL-6) was assessed by western blot and immunocytochemistry. These results were compared with commercially available 2-Desulfated Heparin (2DSH) and standard heparin (SH). Finally, a controlled delivery system of 2, 3 DSH was designed using chitosan microspheres and collagen as scaffold. Optimal loading of 2, 3 DSH was achieved and the release kinetics were tuned to follow a controlled release pattern. The steady state concentration of 2, 3 DSH was found to be optimal to elicit anti-inflammatory property and could achieve inhibition of E-selectin expression while unaffecting the normal clotting cascade. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 95A: 118-128, 2010. C1 [Lakshmi, T. S. Ramyaa; Shanmugasundaram, N.; Shanmuganathan, S.; Meenakshi, J.; Babu, Mary] Cent Leather Res Inst, Biomat Div, Madras 600020, Tamil Nadu, India. [Shanmugasundaram, N.; Shanmuganathan, S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Karthikeyan, K.] Cent Leather Res Inst, Organ Lab, Madras 600020, Tamil Nadu, India. RP Babu, M (reprint author), Cent Leather Res Inst, Biomat Div, Madras 600020, Tamil Nadu, India. EM Babumary2000@yahoo.com OI Natesan, Shanmugasundaram/0000-0003-4213-3111 NR 29 TC 10 Z9 10 U1 1 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1549-3296 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD OCT PY 2010 VL 95A IS 1 BP 118 EP 128 DI 10.1002/jbm.a.32791 PG 11 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 645IU UT WOS:000281448700012 PM 20540094 ER PT J AU Olson, CA Thornton, JA Adam, GE Lieberman, HR AF Olson, Craig A. Thornton, Jennifer A. Adam, Gina E. Lieberman, Harris R. TI Effects of 2 Adenosine Antagonists, Quercetin and Caffeine, on Vigilance and Mood SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Article DE dietary supplement; cognitive performance; flavonoid; alertness; fatigue ID POTENTIALLY ANTICARCINOGENIC FLAVONOIDS; PERFORMANCE LIQUID-CHROMATOGRAPHY; HEART-DISEASE; COGNITIVE PERFORMANCE; DRIVER SLEEPINESS; VISUAL VIGILANCE; A(2A) RECEPTORS; ABSORPTION; GLYCOSIDES; STRESS AB Quercetin, a phenolic flavonoid found in small quantities in some fruits and vegetables, is an adenosine receptor antagonist in vitro marketed as a dietary supplement for purported caffeine-like effects. A double-blind, placebo-controlled, between-subjects study was conducted to compare the behavioral effects of quercetin to a central adenosine receptor antagonist, caffeine. Fifty-seven volunteers received either 2000 mg of quercetin dihydrate (a dose estimated based on in vitro receptor binding to be equivalent in potency to 200 mg of caffeine), placebo, or 200 mg of caffeine. One hour later, a 45-minute visual vigilance task was administered. The Profile of Mood States questionnaire was completed before treatment and immediately after vigilance testing. On the vigilance task, caffeine increased the number of stimuli detected (P < 0.02) and decreased the reaction time (P = 0.001). Caffeine increased self-reported vigor and reduced fatigue and total mood disturbance Profile of Mood States scores compared with placebo. Quercetin did not significantly alter any parameter, but values were typically intermediate between caffeine and placebo on those tests affected by caffeine. Quercetin is unlikely to have any effects when consumed by humans in quantities present in the diet or in dietary supplements. Caffeine (200 mg) administration resulted in the expected effects on vigilance and mood. C1 [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Olson, Craig A.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA. [Thornton, Jennifer A.] David Grant USAF Med Ctr, Clin Investigat Facil, Travis AFB, Fairfield, CA USA. [Adam, Gina E.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, 42 Kansas St, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU US Army Medical Research and Material Command (USAMRMC) FX This work was supported by the US Army Medical Research and Material Command (USAMRMC). The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Human subjects participated after giving their free and informed voluntary consent. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Approved for public release; distribution is unlimited. NR 58 TC 6 Z9 7 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-0749 J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD OCT PY 2010 VL 30 IS 5 BP 573 EP 578 DI 10.1097/JCP.0b013e3181ee0f79 PG 6 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA 650JY UT WOS:000281846400013 PM 20814335 ER PT J AU Ching, M AF Ching, Mihael TI Overcoming ADHD: Helping Your Child Become Calm, Engaged, and Focused-Without a Pill SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Book Review C1 [Ching, Mihael] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Ching, M (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-206X J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD OCT PY 2010 VL 31 IS 8 BP 677 EP 677 PG 1 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA 670AV UT WOS:000283393100008 ER PT J AU Brown, DJ AF Brown, Daniel J. TI SMALL BOWEL PERFORATION CAUSED BY MULTIPLE MAGNET INGESTION SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article C1 Brooke Army Med Ctr, SAUSHEC Emergency Med, MCHE EM, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Brown, DJ (reprint author), Brooke Army Med Ctr, SAUSHEC Emergency Med, MCHE EM, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 2 TC 8 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD OCT PY 2010 VL 39 IS 4 BP 497 EP 498 DI 10.1016/j.jemermed.2008.04.007 PG 2 WC Emergency Medicine SC Emergency Medicine GA 663DC UT WOS:000282862200014 PM 18930371 ER PT J AU de Bejar, LA AF de Bejar, Luis A. TI Time-Domain Hydrodynamic Forces on Rigid Dams with Reservoir Bottom Absorption of Energy SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article DE Earthquakes; Hydrodynamics; Reservoirs; Absorption; Response spectra; Seismic analysis; Dams ID CONCRETE GRAVITY DAMS; FOUNDATION ROCK INTERACTION; EARTHQUAKE RESPONSE; SEDIMENT AB In this investigation, a two-dimensional time-domain closed-form mathematical model for the hydrodynamic forces on the upstream vertical face of a given rigid dam subjected to a specified horizontal ground motion accelerogram was developed. The model includes the absorption of energy at the elastic reservoir bottom, characterized by the impedance ratio of the sub-bottom materials with respect to water (alpha). The formulated boundary-value problem is solved in Laplace's domain and subsequently transformed back to the time domain. Response spectra for the hydrodynamic base shear force and overturning moment are constructed for extreme values of the parameter alpha. It is found that, frequently, including the solid-foundation elasticity in the reservoir model attenuates the resultant hydrodynamic forces on a rigid barrier, as compared to the results for the case of a rigid reservoir foundation. In this case, the elasticity of the sub-bottom materials constitutes an effective energy dissipating mechanism (radiation damping). By contrast, for sub-bottom materials with less-than-water impedance, amplification of the effective earthquake forces is obtained, as compared to the results for the case of a rigid reservoir foundation. C1 USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. FU Department of the Army, Corps of Engineers, Headquarters; Office of the Chief of Engineers; Army Engineer District FX This investigation was conducted under the Work Unit "Nonlinear Behavior and Failure Mechanisms of Concrete Dams (Foundation and Bottom Absorption)," of the Earthquake Engineering Research Program, part of the Research Program on Civil Works sponsored by the Department of the Army, Corps of Engineers, Headquarters. The writers gratefully acknowledges the support and guidance provided by the Office of the Chief of Engineers and by the Army Engineer District representatives in the Field Review Group. Approved for public release; distribution is unlimited. Permission to publish was granted by the Director of the Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 20 TC 2 Z9 2 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD OCT PY 2010 VL 136 IS 10 BP 1271 EP 1280 DI 10.1061/(ASCE)EM.1943-7889.0000174 PG 10 WC Engineering, Mechanical SC Engineering GA 662VZ UT WOS:000282843700008 ER PT J AU Zhu, TL Walsh, D DesJardins, J Roychoudhury, S Holcomb, FH Feickert, CA AF Zhu, Tianli Walsh, Dennis DesJardins, Joel Roychoudhury, Subir Holcomb, Franklin H. Feickert, Carl A. TI Microlith Supported Sulfur Tolerant Catalyst for Autothermal Reforming of E85 Fuel SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article ID NOBLE-METAL CATALYSTS; HYDROGEN-PRODUCTION; PARTIAL OXIDATION; CELL APPLICATIONS; ETHANOL; METHANE; PERFORMANCE; REACTORS; GASOLINE; RH AB Under a U.S. Army program, PCI has developed autothermal reforming catalysts for E85 to provide stable performance in the presence of fuel sulfur as well as corrosion inhibitors. The catalysts build on PCI's Microlith (TM) catalyst technology and used PCI's proprietary formulations. A stable performance was demonstrated through short-term testing (70-80h) using high sulfur doped (100 ppm) fuel. At 1.11 O:C and 1.25 S:C, nearly complete conversion and 70% + reforming efficiency (LHV based) were achieved on stabilized catalysts in the presence of 20 ppm feed sulfur. The effect of ceria addition into an alumina based support was also examined. [DOI: 10.1115/1.3005574] C1 [Zhu, Tianli; Walsh, Dennis; DesJardins, Joel; Roychoudhury, Subir] Precis Combust Inc, N Haven, CT 06473 USA. [Holcomb, Franklin H.; Feickert, Carl A.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Zhu, TL (reprint author), Precis Combust Inc, 410 Sackett Point Rd, N Haven, CT 06473 USA. FU U.S. Army (Army Corp of Engineers Construction Engineering Research Laboratory (CERL)) FX We are grateful to the U.S. Army (Army Corp of Engineers Construction Engineering Research Laboratory (CERL)) for supporting this work. We are also thankful to the engineers and technicians at PCI who helped make the project successful. NR 29 TC 2 Z9 2 U1 0 U2 4 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD OCT PY 2010 VL 7 IS 5 AR 051002 DI 10.1115/1.3005574 PG 8 GA 628TH UT WOS:000280144100002 ER PT J AU Sharp, MK Dobry, R Phillips, R AF Sharp, Michael K. Dobry, Ricardo Phillips, Ryan TI CPT-Based Evaluation of Liquefaction and Lateral Spreading in Centrifuge SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article DE Centrifuge; Liquefaction; Lateral spreading; Cone penetrometer ID SOIL LIQUEFACTION; SAND; RESISTANCE; PERMEABILITY; PREDICTION AB Two series of centrifuge model tests were conducted using Nevada sand. Four saturated models placed in a mildly inclined laminar box and simulating a 6-m-thick deposit were shaken inducing liquefaction effects and lateral spreading. The sand was deposited at a relative density, D(r)=45 or 75%; two of the 45% models were subjected to overconsolidation or preshaking. The second series involved in-flight measurements of static cone tip penetration resistance, q(c), simulating the standard cone penetration test (CPT) 36-mm cone. Values of q(c) increased with D(r), overconsolidation, and preshaking. A normalized resistance, q(c1N), was assigned to each of the four liquefaction/lateral spreading models. Increases in D(r), overconsolidation, and preshaking decreased liquefaction and ground deformation, but relative density alone captured these effects rather poorly. Conversely, q(c1N) predicted extremely well the liquefaction and lateral spreading response of the four models, confirming Seed's hypothesis to explain the success of penetration-based seismic liquefaction charts. The depth to liquefaction measured in the four centrifuge models is consistent with the field CPT liquefaction chart. C1 [Sharp, Michael K.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dobry, Ricardo] Rensselaer Polytech Inst, Dept Civil & Environm Eng, Troy, NY 12180 USA. [Phillips, Ryan] Mem Univ Newfoundland, Ctr Cold Ocean Resources Engn, St John, NF A1B 3X5, Canada. RP Sharp, MK (reprint author), Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 42 TC 11 Z9 15 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD OCT PY 2010 VL 136 IS 10 BP 1334 EP 1346 DI 10.1061/(ASCE)GT.1943-5606.0000338 PG 13 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 650MJ UT WOS:000281853300003 ER PT J AU Woodrow, JP Shlobin, OA Barnett, SD Burton, N Nathan, SD AF Woodrow, James P. Shlobin, Oksana A. Barnett, Scott D. Burton, Nelson Nathan, Steven D. TI Comparison of bronchiolitis obliterans syndrome to other forms of chronic lung allograft dysfunction after lung transplantation SO JOURNAL OF HEART AND LUNG TRANSPLANTATION LA English DT Article DE lung transplantation; chronic rejection; chronic lung allograft dysfunction; bronchiolitis obliterans; bronchiolitis obliterans syndrome ID AZITHROMYCIN THERAPY; RECIPIENTS; STANDARDIZATION AB BACKGROUND: The radiographic presence of allograft infiltrates is atypical of bronchiolitis obliterans (BO) and inconsistent with the definition of bronchiolitis obliterans requires that restrictive processes are ruled out. The natural history of these other forms of chronic allograft dysfunction has not been well characterized. We examined the prognostic significance of radiographic and spirometric restrictive processes in comparison to BOS among lung transplant recipients. METHODS: We performed a retrospective review of lung transplant recipients with chronic lung allograft dysfunction (CLAD) as defined by spirometry. Subgroups based on the presence or absence of persistent radiographic abnomalities were labeled as non-specific (CLAD-NS) and CLAD due to BOS (CLAD-BOS), respectively. The CLAD-BOS group was further divided into obstructive (OBOS) and restrictive (RBOS) phenotypes' based on spirometry. Groups were compared with respect to survival and decline in forced expiratory volume in l second (FEV(1)). RESULTS: Among 241 lung transplant recipients, 96 (40%) were identified as having CLAD, of whom 62 (65%) had CLAD-BOS and 34 (35%) CLAD-NS. No difference between groups was identified with respect to post-CLAD survival or decline in FEV(1). CLAD-BOS subgroups included 35 (56%) patients with OBOS and 27 (44%) with RBOS. There was no difference in these subgroups with respect to survival or subsequent FEV(1) decline. CONCLUSIONS: Patients with CLAD and persistent radiographic, infiltrates have a similar prognosis to BOS patients but may still represent a clinically distinct phenotype. BOS patients frequently exhibited a restrictive pattern on spirometry, which also did not offer further prognostic information, but could still represent a unique disease phenotype. J Heart Lung Transplant 2010;29:1159-64 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved. C1 [Woodrow, James P.] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [Shlobin, Oksana A.; Barnett, Scott D.; Burton, Nelson; Nathan, Steven D.] Inova Fairfax Hosp, Lung Transplant Program, Falls Church, VA USA. RP Woodrow, JP (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jake.woodrow@us.army.mil NR 18 TC 30 Z9 30 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1053-2498 J9 J HEART LUNG TRANSPL JI J. Heart Lung Transplant. PD OCT PY 2010 VL 29 IS 10 BP 1159 EP 1164 DI 10.1016/j.healun.2010.05.012 PG 6 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery; Transplantation SC Cardiovascular System & Cardiology; Respiratory System; Surgery; Transplantation GA 660EE UT WOS:000282621900008 PM 20580267 ER PT J AU de Bejar, LA Stockstill, RL AF de Bejar, Luis A. Stockstill, Richard L. TI Hydrodynamic Forces on Spillway Torque-Tube Gates SO JOURNAL OF HYDRAULIC ENGINEERING LA English DT Article DE Hydraulic forces; Hydraulic pressure field; Hydraulic physical models; Hydraulic structures; Navigable spillways; Torque-tube gates ID DESIGN GUIDELINES AB The critical hydraulic configuration for a set of torque-tube gates controlling the flow through the navigable portion of a spillway was experimentally identified. In this paper, an analytical model for the upstream pressure field on a typical gate within the set is constructed. The gate rotation from the maximum elevation (gate in closed position) and the hydraulic torque transmitted by the pressure field to the gate tube are formulated. Mean values of parameters of response are often sufficient for the preliminary design of a gate. The dispersions of these parameters of response, which are necessary for the final design of a gate, may be computed using the corresponding mean-square values. These were obtained empirically in a flume from experiments on a 1/15-scale physical model of a set of three prototype gates for the Montgomery Point Lock and Dam project. Theoretical predictions of parameter mean and mean-square values compare well with the average corresponding statistics obtained experimentally. C1 [de Bejar, Luis A.; Stockstill, Richard L.] USA, Erdc, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), USA, Erdc, Vicksburg, MS 39180 USA. EM Luis.A.DeBejar@erdc.usace.army.mil; Richard.L.Stockstill@erdc.usace.army.mil FU Headquarters, U. S. Army Corps of Engineers FX This investigation was conducted at the U.S. Army Engineer Research and Development Center through the Montgomery Point Lock and Dam Gate Study, sponsored by Headquarters, U. S. Army Corps of Engineers at the request of the U.S. Army Engineer District, Little Rock. The writers gratefully acknowledge permission from the authorities at the U. S. Army Engineer District, Little Rock, and from the Chief of Engineers to publish the information in this paper. NR 19 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 EI 1943-7900 J9 J HYDRAUL ENG JI J. Hydraul. Eng.-ASCE PD OCT PY 2010 VL 136 IS 10 BP 681 EP 692 DI 10.1061/(ASCE)HY.1943-7900.0000216 PG 12 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 650MQ UT WOS:000281854000001 ER PT J AU van Panhuis, WG Gibbons, RV Endy, TP Rothman, AL Srikiatkhachorn, A Nisalak, A Burke, DS Cummings, DAT AF van Panhuis, Willem G. Gibbons, Robert V. Endy, Timothy P. Rothman, Alan L. Srikiatkhachorn, Anon Nisalak, Ananda Burke, Donald S. Cummings, Derek A. T. TI Inferring the Serotype Associated with Dengue Virus Infections on the Basis of Pre- and Postinfection Neutralizing Antibody Titers SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ORIGINAL ANTIGENIC SIN; PRIMARY-SCHOOL CHILDREN; HEMORRHAGIC-FEVER; EARLY-DIAGNOSIS; KAMPHAENG PHET; THAILAND; VACCINE; PATHOGENESIS; CHALLENGES; BANGKOK AB Background. Currently, the only tests capable of determining the serotype associated with dengue virus (DENV) infection require sampling during the period of acute viremia. No test can accurately detect the serotype associated with past DENV infections. The standard assay for determination of serotype-specific antibody against DENV is the plaque reduction neutralization test (PRNT), although performance of this test continues to be evaluated. Methods. From a cohort study among schoolchildren in Thailand, PRNT values were determined in serum samples collected before and after infection. A multinomial logistic regression model was used to infer the serotype associated with intercurrent DENV infections. Models were validated based on polymerase chain reaction identification of DENV serotypes. Results. The serotype associated with DENV infection inferred by the model corresponded with polymerase chain reaction in 67.6% of cases, and the kappa statistic was 0.479. A model for 35 cases with primary seroconversion correctly identified the DENV serotypes causing infection in 77.1% of cases, compared with 66.9%, using a model for 169 cases with secondary seroconversion. The best model using only postinfection PRNT values correctly inferred the DENV serotype causing infection in 60.3% of cases. Conclusions. A statistical model based on both pre- and postinfection PRNT values can be used to infer the serotype associated with DENV infections in prospective studies and vaccine trials. C1 [van Panhuis, Willem G.; Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY USA. [Rothman, Alan L.; Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Gibbons, Robert V.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, Bangkok 10400, Thailand. RP van Panhuis, WG (reprint author), 127 Parran Hll,130 DeSoto St, Pittsburgh, PA 15261 USA. EM wav10@pitt.edu OI /0000-0002-5704-8094 FU Bill & Melinda Gates Foundation; National Institutes of Health [1U01-GM070708, 1R01 TW008246-01, P01 AI034533]; Burroughs Wellcome Fund; US Military Infectious Disease Research Program FX The Bill & Melinda Gates Foundation (W. G. v. P., D. S. B., and D. A. T. C); National Institutes of Health (grants 1U01-GM070708 [to D. S. B. and D. A. T. C], 1R01 TW008246-01 [to D. A. T. C.], and NIH P01 AI034533 [to R. V. G., T. P. E., A. L. R., and A.N.]); the Burroughs Wellcome Fund (Career Award at the Scientific Interface [to D. A. T. C.]); and the US Military Infectious Disease Research Program. NR 41 TC 23 Z9 23 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2010 VL 202 IS 7 BP 1002 EP 1010 DI 10.1086/656141 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 651FR UT WOS:000281912100004 PM 20738205 ER PT J AU Crum-Cianflone, NF Hullsiek, KH Roediger, M Ganesan, A Patel, S Landrum, ML Weintrob, A Agan, BK Medina, S Rahkola, J Hale, BR Janoff, EN AF Crum-Cianflone, Nancy F. Hullsiek, Katherine Huppler Roediger, Mollie Ganesan, Anuradha Patel, Sugat Landrum, Michael L. Weintrob, Amy Agan, Brian K. Medina, Sheila Rahkola, Jeremy Hale, Braden R. Janoff, Edward N. CA Infect Dis Clinical Res Program HI TI A Randomized Clinical Trial Comparing Revaccination with Pneumococcal Conjugate Vaccine to Polysaccharide Vaccine among HIV-Infected Adults SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; PROTECTIVE ANTIBODY-RESPONSES; CELL TRANSPLANTATION; DOUBLE-BLIND; DISEASE; CHILDREN; IMMUNOGENICITY; IMMUNIZATION; BACTEREMIA; TYPE-1 AB Background. The risk of pneumococcal disease persists, and antibody responses to revaccination with the 23-valent polysaccharide vaccine (PPV) are low among human immunodeficiency virus (HIV)-infected adults. We determined whether revaccination with the 7-valent pneumococcal conjugate vaccine (PCV) would enhance these responses. Methods. In a randomized clinical trial, we compared the immunogenicity of revaccination with PCV (np) or PPV (n = 73) among HIV-infected adults (median CD4 cell count, 533 cells/mm(3)) who had been vaccinated with PPV 3-8 years earlier. HIV-uninfected adults (n = 25) without prior pneumococcal vaccination received 1 dose of PCV. A positive response was defined as a >= 2-fold increase (from baseline to day 60) in capsule-specific immunoglobulin G, with a postvaccination level >= 1000 ng/mL for at least 2 of the 4 serotypes. Results. HIV-infected persons demonstrated a higher frequency of positive antibody responses to PCV than to PPV (57% vs 36%) (Pp. 004) and greater mean changes in the immunoglobulin G concentration from baseline to day 60 for serotypes 4, 9V, and 19F (P<.05, for all), but not for serotype 14. However, by day 180, both outcomes were similar. Responses to PCV were greater in frequency and magnitude for all serotypes in HIV-uninfected adults, compared with those in HIV-infected adults. Conclusions. Among persons with HIV infection, revaccination with PCV was only transiently more immunogenic than PPV, and responses were inferior to those in HIV-uninfected subjects with primary vaccination. Pneumococcal vaccines with more robust and sustained immunogenicity are needed for HIV-infected adults. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Hullsiek, Katherine Huppler; Roediger, Mollie; Ganesan, Anuradha; Landrum, Michael L.; Weintrob, Amy; Agan, Brian K.; Medina, Sheila; Hale, Braden R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] USN, Med Ctr, Infect Dis Clin, Bethesda, MD 20814 USA. [Hullsiek, Katherine Huppler; Roediger, Mollie] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Patel, Sugat] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Rahkola, Jeremy; Janoff, Edward N.] Univ Colorado, Div Infect Dis, Mucosal & Vaccine Res Program Colorado, Denver, CO 80202 USA. [Janoff, Edward N.] Denver Vet Affairs Med Ctr, Denver, CO USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil; braden.hale@med.navy.mil OI Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU NIAID NIH HHS [Y01 AI005072, Y1-AI-5072] NR 35 TC 42 Z9 44 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2010 VL 202 IS 7 BP 1114 EP 1125 DI 10.1086/656147 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 651FR UT WOS:000281912100016 PM 20795819 ER PT J AU Regwan, S Hulten, EA Martinho, S Slim, J Villines, TC Mitchell, J Slim, AM AF Regwan, Steven Hulten, Edward A. Martinho, Shaun Slim, Jennifer Villines, Todd C. Mitchell, Joshua Slim, Ahmad M. TI Marathon Running as a Cause of Troponin Elevation: A Systematic Review and Meta-Analysis SO JOURNAL OF INTERVENTIONAL CARDIOLOGY LA English DT Review ID BRAIN NATRIURETIC PEPTIDE; PROLONGED STRENUOUS EXERCISE; ISCHEMIA-MODIFIED ALBUMIN; HUMAN SKELETAL-MUSCLE; KINASE-MB-ISOENZYME; CARDIAC-TROPONIN; MYOCARDIAL INJURY; BOSTON-MARATHON; PLASMA INTERLEUKIN-6; ENDURANCE EXERCISE AB Background: Cardiac troponin (cTn) has high sensitivity and specificity for myocardial injury in acute coronary syndrome. Our objective was to review the published literature regarding the incidence of cTn elevations in marathon runners. Methods: Systematic review and meta-analysis of observational studies published before September 2009. We included studies of patients who had completed a marathon and had serum cTn levels within 24 hours. The primary outcome was the odds ratio for conversion of a normal pre-marathon cTn to an elevated post-marathon cTn. Secondary outcomes included the pooled prevalence of cTn elevation and comparison of the odds ratio for post-marathon elevation of cTnI versus cTnT. Results: Sixteen studies of 939 participants met criteria for inclusion. The mean age was 39 +/- 4 years and patients were 74 +/- 14% male. There were 6 pre-marathon cTn elevations and 579 post-race elevations. The pooled odds ratio for converting from a normal pre-race to an elevated post-race cTn was 51.84 (95% CI 16-168, I2 = 66%, P < 0.001). The pooled incidence of a post-marathon cTn elevation was 51% (95% CI 33-69, I2 = 98%, P < 0.001) of all runners. For the primary outcome there was no significant publication bias. Age and gender were not associated, but publication date and assay sensitivity was associated with cTn elevation. cTnI was less commonly elevated versus cTnT. Conclusions: The available data demonstrate that cTn levels are frequently elevated after a marathon with unclear cardiovascular significance. This elevation of cTn appears to be consistent among a diverse patient population. (J Interven Cardiol 2010;23:443-450). C1 San Antonio Mil Med Ctr, Serv Cardiol, Washington, DC USA. Walter Reed Army Med Ctr, Texas Cardiol Serv, Washington, DC 20307 USA. RP Slim, AM (reprint author), Brooke Army Med Ctr, Cardiol Serv MCHE MDC, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM Ahmad.slim@US.ARMY.MIL OI Villines, Todd/0000-0003-2674-3702; Hulten, Edward/0000-0001-9281-0032 NR 38 TC 29 Z9 30 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0896-4327 J9 J INTERV CARDIOL JI J. Interv. Cardiol. PD OCT PY 2010 VL 23 IS 5 BP 443 EP 450 DI 10.1111/j.1540-8183.2010.00575.x PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 658UA UT WOS:000282513700004 PM 20663014 ER PT J AU Lantova, L Ghosh, K Svobodova, M Braig, HR Rowton, E Weina, P Volf, P Votypka, J AF Lantova, Lucie Ghosh, Kashinath Svobodova, Milena Braig, Henk R. Rowton, Edgar Weina, Peter Volf, Petr Votypka, Jan TI The life cycle and host specificity of Psychodiella sergenti n. sp. and Ps. tobbi n. sp. (Protozoa: Apicomplexa) in sand flies Phlebotomus sergenti and Ph. tobbi (Diptera: Psychodidae) SO JOURNAL OF INVERTEBRATE PATHOLOGY LA English DT Article DE Psychodiella; Gregarine; Phlebotomus; Lutzomyia; Cross-infection; Life cycle differences; Blood meal; SSU rDNA phylogeny ID ASCOGREGARINA-TAIWANENSIS APICOMPLEXA; AEDES-AEGYPTI; LECUDINIDAE; MOSQUITOS; PATHOGENICITY; EUGREGARINIDA; INFECTIONS; GREGARINES; CULICIDAE; FLORIDA AB Two new gregarines in the recently erected genus Psychodiella (formerly Ascogregarina), Psychodiella sergenti n. sp. and Psychodiella tobbi n. sp., are described based on morphology and life cycle observations conducted on larvae and adults of their natural hosts, the sand flies Phlebotomus sergenti and Phlebotomus tobbi, respectively. The phylogenetic analyses inferred from small subunit ribosomal DNA (SSU rDNA) sequences indicate the monophyly of newly described species with Psychodiella chagasi. Ps. sergenti n. sp. and Ps. tobbi n. sp. significantly differ from each other in the life cycle and in the size of life stages. The sexual development of Ps. sergenti n. sp. (syzygy, formation of gametocysts and oocysts) takes place exclusively in blood-fed Ph. sergenti females, while the sexual development of Ps. tobbi n. sp. takes place also in males and unfed females of Ph. tobbi. The susceptibility of Phlebotomus perniciosus, Phlebotomus papatasi, Ph. sergenti, Ph. tobbi, and Phlebotomus arabicus to both gregarines was examined by exposing 1st instar larvae to parasite oocysts. High host specificity was observed, as both gregarines were able to fully develop and complete regularly the life cycle only in their natural hosts. Both gregarines are considered as serious pathogens in laboratory-reared colonies of Old World sand flies. (C) 2010 Elsevier Inc. All rights reserved. C1 [Votypka, Jan] Charles Univ Prague, Fac Sci, Dept Parasitol, Prague 12844, Czech Republic. [Ghosh, Kashinath; Rowton, Edgar] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Braig, Henk R.] Bangor Univ, Sch Biol Sci, Bangor, Gwynedd, Wales. [Weina, Peter] Walter Reed Army Inst Res, Dept Pharmacol, Silver Spring, MD USA. RP Votypka, J (reprint author), Charles Univ Prague, Fac Sci, Dept Parasitol, Vinicna 7, Prague 12844, Czech Republic. EM vapid@natur.cuni.cz RI Weina, Peter/A-2120-2011; Rowton, Edgar/A-4474-2012; Volf, Petr/C-4300-2012; Votypka, Jan/C-5313-2012; Rowton, Edgar/A-1975-2011; Braig, Henk/I-5477-2013; Svobodova, Milena/E-1355-2011 OI Volf, Petr/0000-0003-1790-1123; Votypka, Jan/0000-0002-0552-9363; Rowton, Edgar/0000-0002-1979-1485; Braig, Henk/0000-0001-9592-1141; FU Czech Ministry of Education [MSM0021620828, LC06009]; National Research Council, National Academy of Sciences, USA FX The work was supported by the Czech Ministry of Education (MSM0021620828, LC06009) and National Research Council, National Academy of Sciences, USA (KG.). NR 25 TC 13 Z9 13 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-2011 J9 J INVERTEBR PATHOL JI J. Invertebr. Pathol. PD OCT PY 2010 VL 105 IS 2 BP 182 EP 189 DI 10.1016/j.jip.2010.07.001 PG 8 WC Zoology SC Zoology GA 650DN UT WOS:000281829300010 PM 20627106 ER PT J AU Genovese, RF Benton, BJ Oubre, JL Fleming, PJ Jakubowski, EM Mioduszewski, RJ AF Genovese, Raymond F. Benton, Bernard J. Oubre, John L. Fleming, Patrick J. Jakubowski, E. Michael Mioduszewski, Robert J. TI Evaluation of miosis, behavior and cholinesterase inhibition from low-level, whole-body vapor exposure to soman in African green monkeys (Chlorocebus sabeus)* SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE African green monkey; Chlorocebus sabeus; cognition; GD; miosis; serial probe recognition; soman ID TOKYO SUBWAY; SARIN VAPOR; ACETYLCHOLINESTERASE ACTIVITY; NERVOUS-SYSTEM; RHESUS-MONKEYS; ACUTE TOXICITY; ERYTHROCYTE; TOLERANCE; RATS; ORGANOPHOSPHATES AB Background Relatively little is known about the effects of very low-level exposures to nerve agents where few signs or symptoms are present. Methods African green monkeys (Chlorocebus sabeus) (n = 8) were exposed for 10 min, whole-body, to a single concentration of soman (0.028-0.891 mg/m3). Results EC(50) values for miosis were determined to be 0.055 mg/m3 and 0.132 mg/m3 when defined as a 50 percent reduction in pupil area and diameter, respectively. In general, performance on a serial probe recognition task remained unchanged at lower concentrations, but responding was suppressed at the largest concentration tested. Soman produced concentration-dependent inhibition of acetylcholinesterase activity and, to a lesser extent, butyrylcholinesterase activity. Conclusions These results characterize threshold soman exposure concentrations that produce miosis in the absence of other overt signs of toxicity and extend previous studies indicating that miosis is a valuable early indicator for the detection of soman vapor exposure. C1 [Genovese, Raymond F.; Oubre, John L.; Fleming, Patrick J.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Benton, Bernard J.; Mioduszewski, Robert J.] USA, Operat Toxicol Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Jakubowski, E. Michael] USA, Analyt Toxicol Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM Raymond.Genovese@US.ARMY.MIL FU Defense Threat Reduction Agency FX The authors thank Kathy Crouse, Charles Crouse, Christina C. Johnson, David McCaskey, Marcia A. Caputo, Dr. Stanley W. Hulet, Dr. Paul Dabisch, David C. Burnett, Ronald A. Evans, Julie A. Renner, Jacqueline A. Scotto, Joseph Gruver and MAJ Kevin W. Nemelka for helpful contributions to the studies. This work was supported by the Defense Threat Reduction Agency. NR 28 TC 1 Z9 1 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD OCT PY 2010 VL 39 IS 5 BP 318 EP 327 DI 10.1111/j.1600-0684.2010.00413.x PG 10 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 646NP UT WOS:000281549400003 PM 20412376 ER PT J AU Waits, CM Hanrahan, B Lee, I AF Waits, C. Mike Hanrahan, Brendan Lee, Ivan TI Multiplexed electrospray scaling for liquid fuel injection SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article; Proceedings Paper CT 9th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2009) CY DEC 01-04, 2009 CL Leuven, BELGIUM SP Univ Maryland, Transoucer Res Fdn, NSF ID CONE; LAWS; JET; CHARGE AB Evaporation and space-charge requirements are evaluated to understand the effect of device scaling and fuel preheating for a liquid fuel injector using a multiplexed electrospray (MES) configuration in compact combustion applications. This work reveals the influence of the droplet diameter, droplet velocity and droplet surface temperature as well as the surrounding gas temperature on the size and performance of microfabricated MES. Measurements from MES devices are used in the model to accurately account for the droplet diameter versus flow rate relationship, the minimum droplet diameter and the relevant droplet velocities. A maximum extractor electrode to ground electrode distance of 3.1 mm required to overcome space-charge forces is found to be independent of voltage or droplet velocity for large levels of multiplexing. This maximum distance also becomes the required evaporation length scale which imposes minimum fuel pre-heating requirements for large flow densities. Required fuel preheating is therefore evaluated for both ethanol and 1-butanol with combustor parameters relevant to fuel reformation, thermoelectric conversion, thermophotovoltaic conversion and thermionic conversion. C1 [Waits, C. Mike; Hanrahan, Brendan; Lee, Ivan] USA, Res Lab, Adelphi, MD 20783 USA. RP Waits, CM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mike.waits@us.army.mil RI Lee, Ivan/H-6444-2011 NR 21 TC 4 Z9 4 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD OCT PY 2010 VL 20 IS 10 AR 104010 DI 10.1088/0960-1317/20/10/104010 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 655SR UT WOS:000282270300011 ER PT J AU Kuehn, JT AF Kuehn, John T. TI The U.S. Navy General Board and Naval Arms Limitation: 1922-1937 SO JOURNAL OF MILITARY HISTORY LA English DT Article AB The naval treaty system inaugurated at Washington in 1922 channeled innovation in the U.S. Navy. The Washington Naval Treaty eliminated the ability of the United States to construct new bases or to improve existing ones in the western Pacific. It fell to the General Board of the Navy to implement the clauses of the Washington Treaty. The General Board was also charged with the responsibility of preparing and attending subsequent naval conferences during the period. The General Board was the critical link between the Navy and the naval treaty system. As such, the General Board both shaped and was shaped by the treaty system. C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 33 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1129 EP 1160 PG 32 WC History SC History GA 663BC UT WOS:000282857000005 ER PT J AU Driscoll, RS AF Driscoll, Robert S. TI Women Doctors in War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Driscoll, Robert S.] USA, Med Command, Off Med Hist, Washington, DC USA. RP Driscoll, RS (reprint author), USA, Med Command, Off Med Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1289 EP 1291 PG 3 WC History SC History GA 663BC UT WOS:000282857000045 ER PT J AU Fischer, JR AF Fischer, Joseph R. TI Jungle of Snakes: A Century of Counterinsurgency Warfare from the Philippines to Iraq. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Fischer, Joseph R.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Fischer, JR (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1294 EP 1297 PG 4 WC History SC History GA 663BC UT WOS:000282857000048 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI Operation Dragoon: The Liberation of Southern France 1944 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bourque, Stephen A.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Bourque, SA (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1321 EP 1322 PG 2 WC History SC History GA 663BC UT WOS:000282857000065 ER PT J AU House, JM AF House, Jonathan M. TI The Atlantic and Its Enemies: A History of the Cold War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1329 EP 1330 PG 2 WC History SC History GA 663BC UT WOS:000282857000071 ER PT J AU Schifferle, PJ AF Schifferle, Peter J. TI Combat in Korea: Striking Back, March-April 1951 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Schifferle, Peter J.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Schifferle, PJ (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2010 VL 74 IS 4 BP 1333 EP 1334 PG 2 WC History SC History GA 663BC UT WOS:000282857000074 ER PT J AU Ottens, AK Bustamante, L Golden, EC Yao, CP Hayes, RL Wang, KKW Tortella, FC Dave, JR AF Ottens, Andrew K. Bustamante, Liliana Golden, Erin C. Yao, Changping Hayes, Ronald L. Wang, Kevin K. W. Tortella, Frank C. Dave, Jitendra R. TI Neuroproteomics: A Biochemical Means To Discriminate the Extent and Modality of Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE controlled cortical impact; middle cerebral artery occlusion; ischemia; proteomics; traumatic brain injury ID NEURON-SPECIFIC ENOLASE; CONTROLLED CORTICAL IMPACT; FOCAL CEREBRAL-ISCHEMIA; CYTOSKELETON-ASSOCIATED PROTEIN; SERUM BIOMARKER CONCENTRATIONS; PROTEOMIC ANALYSIS; CEREBROSPINAL-FLUID; RAT-BRAIN; THERAPEUTIC IMPLICATIONS; INTRACRANIAL-PRESSURE AB Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast biochemical responses following ischemic and traumatic brain injuries in the rat. A middle cerebral artery occlusion (MCAO) model was employed in groups of 30-min and 2-h focal neocortical ischemia with reperfusion. Neuroproteomes were assessed via tandem cation-anion exchange chromatography-gel electrophoresis, followed by reversed-phase liquid chromatography-tandem mass spectrometry. MCAO results were compared with those from a previous study of focal contusional brain injury employing the same methodology to characterize homologous neocortical tissues at 2 days post-injury. The 30-min MCAO neuroproteome depicted abridged energy production involving pentose phosphate, modulated synaptic function and plasticity, and increased chaperone activity and cell survival factors. The 2-h MCAO data indicated near complete loss of ATP production, synaptic dysfunction with degraded cytoarchitecture, more conservative chaperone activity, and additional cell survival factors than those seen in the 30-min MCAO model. The TBI group exhibited disrupted metabolism, but with retained malate shuttle functionality. Synaptic dysfunction and cytoarchitectural degradation resembled the 2-h MCAO group; however, chaperone and cell survival factors were more depressed following TBI. These results underscore the utility of neuroproteomics for characterizing interactive biochemistry for profiling and contrasting the molecular aspects underlying the pathobiological differences between types of brain injuries. C1 [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Anat, Med Coll Virginia, Richmond, VA 23298 USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Neurobiol, Med Coll Virginia, Richmond, VA 23298 USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Biochem, Med Coll Virginia, Richmond, VA 23298 USA. [Bustamante, Liliana; Golden, Erin C.; Wang, Kevin K. W.] Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA. [Yao, Changping; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. [Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA. RP Ottens, AK (reprint author), Virginia Commonwealth Univ, Dept Anat, Med Coll Virginia, POB 980709, Richmond, VA 23298 USA. EM akottens@vcu.edu RI Ottens, Andrew/K-3352-2012; OI Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DAMD1703-1-0066]; National Institute of Neurological Disorders and Stroke [NS055012] FX Our thanks go to Drs. Povlishock and McGinn Greer for their thoughtful feedback. This work was supported by Department of Defense grant DAMD1703-1-0066, and the National Institute of Neurological Disorders and Stroke grant NS055012. This article was reviewed by the Walter Reed Army Institute of Research, and there was no objection to its presentation and publication. The opinions and assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting the views of the Department of the Army or the Department of Defense. NR 89 TC 20 Z9 20 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT PY 2010 VL 27 IS 10 BP 1837 EP 1852 DI 10.1089/neu.2010.1374 PG 16 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 665OZ UT WOS:000283046600008 PM 20698760 ER PT J AU Shear, DA Lu, XCM Bombard, MC Pedersen, R Chen, ZY Davis, A Tortella, FC AF Shear, Deborah A. Lu, Xi-Chun May Bombard, Matthew C. Pedersen, Rebecca Chen, Zhiyong Davis, Angela Tortella, Frank C. TI Longitudinal Characterization of Motor and Cognitive Deficits in a Model of Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE behavioral assessments; cognitive function; models of injury; penetrating ballistic-like brain injury; traumatic brain injury ID CEREBRAL-ARTERY OCCLUSION; TRAUMATIC BRAIN; POSTTRAUMATIC HYDROCEPHALUS; FUNCTIONAL RECOVERY; PROSPECTIVE MEMORY; PREFRONTAL CORTEX; GUNSHOT WOUNDS; ROTAROD TEST; RAT MODEL; MICE AB Traumatic brain injury (TBI) produces a wide range of motor and cognitive changes. While some neurological symptoms may respond to therapeutic intervention during the initial recovery period, others may persist for many years after the initial insult, and often have a devastating impact on quality of life for the TBI victim. The aim of the current study was to develop neurobehavioral testing parameters designed to provide a longitudinal assessment of neurofunctional deficits in a rodent model of penetrating ballistic-like brain injury (PBBI). We report here a series of experiments in which unilateral frontal PBBI was induced in rats, and motor/cognitive abilities were assessed using a battery of tests ranging from 30 min to 10 weeks post-injury. The results showed that PBBI produced consistent and significant (1) neurological deficits (neuroscore examination: 30 min to 10 weeks post-PBBI), (2) sensorimotor dysfunction in the contralateral forelimb (forelimb asymmetry task: 7 and 21 days), (3) motor dysfunction (balance beam task: 3-7 days; and fixed-speed rotarod task: 3-28 days), and (4) spatial learning deficits in the Morris water maze (MWM) task out to 10 weeks post-injury. Overall, the results of this study demonstrate that PBBI produces enduring motor and cognitive deficits, and identifies the optimal task and testing parameters for facilitating longitudinal screening of promising therapeutic interventions in this brain injury model. C1 [Shear, Deborah A.; Lu, Xi-Chun May; Bombard, Matthew C.; Pedersen, Rebecca; Chen, Zhiyong; Davis, Angela; Tortella, Frank C.] MRMC UWI C, Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. [Bombard, Matthew C.; Pedersen, Rebecca; Davis, Angela] Geneva Fdn, Lakewood, WA USA. RP Shear, DA (reprint author), MRMC UWI C, Walter Reed Army Inst Res, Dept Appl Neurobiol, Bldg 503-2W14, Silver Spring, MD 20910 USA. EM Deborah.Shear@AMEDD.ARMY.MIL RI Shear, Deborah/B-3607-2011; OI Bombard, Matthew/0000-0002-3039-5192 FU Department of the Army [W81XWH-08-2-0127]; U.S. Army Medical Research Acquisition Activity, Fort Detrick, MD FX This work was supported by the Department of the Army, award W81XWH-08-2-0127, with the U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014, as the awarding and administering acquisition office. NR 53 TC 35 Z9 35 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT PY 2010 VL 27 IS 10 BP 1911 EP 1923 DI 10.1089/neu.2010.1399 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 665OZ UT WOS:000283046600015 PM 20684676 ER PT J AU Smith, KW Proctor, SR Ozonoff, A McClean, MD AF Smith, Kristen W. Proctor, Susan R. Ozonoff, Al McClean, Michael D. TI Inhalation Exposure to Jet Fuel (JP8) Among US Air Force Personnel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE exposure assessment; inhalation exposure; jet fuel; JP8 ID DERMAL EXPOSURE; JP-8; NAPHTHALENE; WORKERS AB As jet fuel is a common occupational exposure among military and civilian populations, this study was conducted to characterize jet fuel (JP8) exposure among active duty U.S. Air Force personnel. Personnel (n = 24) were divided a priori into high, moderate, and low exposure groups. Questionnaires and personal air samples (breathing zone) were collected from each worker over 3 consecutive days (72 worker-days) and analyzed for total hydrocarbons (THC), benzene, toluene, ethylbenzene, xylenes, and naphthalene. Air samples were collected from inside the fuel tank and analyzed for the same analytes. Linear mixed-effects models were used to evaluate the exposure data. Our results show that the correlation of THC (a measure of overall JP8 inhalation exposure) with all other analytes was moderate to strong in the a priori high and moderate exposure groups combined. Inhalation exposure to all analytes varied significantly by self-reported JP8 exposure (THC levels higher among workers reporting JP8 exposure), a priori exposure group (THC levels in high group > moderate group > low group), and more specific job task groupings (THC levels among workers in fuel systems hangar group > refueling maintenance group > fuel systems office group > fuel handling group > clinic group), with task groupings explaining the most between-worker variability. Among highly exposed workers, statistically significant job task-related predictors of inhalation exposure to THC indicated that increased time in the hangar; working close to the fuel tank (inside > less than 25 ft > greater than 25 ft), primary job (entrant > attendant/runner/fireguard > outside hangar), and performing various tasks near the fuel tank, such as searching for a leak, resulted in higher JP8 exposure. This study shows that while a priori exposure groups were useful in distinguishing JP8 exposure levels, job task-based categories should be considered in epidemiologic study designs to improve exposure classification. Finally, the strong correlation of THC with naphthalene suggests that naphthalene may be an appropriate surrogate of JP8 exposure. C1 [Smith, Kristen W.; Proctor, Susan R.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Smith, Kristen W.; Proctor, Susan R.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan R.] VA Boston Healthcare Syst, Boston, MA USA. [Ozonoff, Al] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Smith, KW (reprint author), Harvard Univ, Sch Med, 655 Huntington Ave,Bldg 1,Room 1402, Boston, MA 02115 USA. EM ksmith@hsph.harvard.edu RI McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823; Ozonoff, Al/0000-0003-4233-5899 FU U.S. Army Medical Research and Materiel Command [W81XWH-06-1-0105] FX The authors gratefully acknowledge the Air Force personnel who participated in this study. This work was supported by the U.S. Army Medical Research and Materiel Command, grant number W81XWH-06-1-0105. NR 24 TC 12 Z9 12 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD OCT PY 2010 VL 7 IS 10 BP 563 EP 572 DI 10.1080/15459624.2010.503755 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 659AB UT WOS:000282538100003 PM 20694886 ER PT J AU Palo, DE Warden, PJ AF Palo, David E. Warden, Paul J. TI Shrapnel-Induced Mandibular Hypomobility SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article AB Mandibular hypomobility can develop from direct injury to, or as a result of disorders affecting, the supporting structures of the temporomandibular joint. This can be subdivided into intra-articular and extra-articular processes. Ankylosis is commonly associated with trauma (31% to 98%), followed by infections (10% to 49%) and systemic disease (10%).(1) Temporomandibular joint ankylosis is an intra-articular process characterized by fibrous, fibro-osseous, or osseous obliteration of the joint space.(2) Pseudoankylosis involves extracapsular causes of restricted jaw motion that include, but are not limited to, coronoid-zygomatic fusion, coronoid hypertrophy, and muscular fibrosis.(2) Shrapnel injuries can be as devastating as high-velocity gunshot wounds, with functional and esthetic consequences, depending on the velocity, size, shape, and jagged edges of the fragments.(3,4) Traumatic life support measures are paramount during the immediate postinjury setting. The airway and hemodynamic status must be maintained, because the oxygen-carrying capacity is essential for wound healing and the prevention of infection.(3,4) A secure airway controlled with an endotracheal tube or tracheostomy needs early consideration because bleeding and edema can result in airway compromise.(3,4) The securing of the airway should be followed by a comprehensive examination of the patient to reveal additional injuries. C1 [Palo, David E.; Warden, Paul J.] Womack Army Med Ctr, Dept Oral & Maxillofacial Surg, Ft Bragg, NC USA. RP Palo, DE (reprint author), 100 State St,Suite B102, Erie, PA 16507 USA. EM Teampalodsb@aol.com NR 7 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD OCT PY 2010 VL 68 IS 10 BP 2639 EP 2641 DI 10.1016/j.joms.2010.04.008 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 660UD UT WOS:000282670400046 PM 20674125 ER PT J AU Garciano, LO Upadhyaya, SK Jones, RA AF Garciano, Leroy Ortega Upadhyaya, Shrinivasa K. Jones, Randolph A. TI Measurement of soil parameters useful in predicting tractive ability of off-road vehicles using an instrumented portable device SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Instrumented portable soil test device; Cohron sheargraph; Engineering properties of soil; Tractive ability of off-road vehicles ID RESISTANCE; SHEARGRAPH AB An instrumented portable device that measures soil sinkage, shear, and frictional parameters in situ was developed to investigate the complexity of soil-traction device interaction process. The device was tested to determine its ability to measure soil frictional and shear characteristics. Extensive laboratory tests were conducted using dry and moist Capay clay and Yolo loam soils. In addition, field tests were also conducted in a Yolo loam field located at the UC Davis Agricultural Experiment Station. The Cohron sheargraph was also tested under the same laboratory experimental conditions to determine adhesion, soil metal friction, cohesion, and angle of internal friction of soil. The analysis of experimental data indicated that soil adhesion and soil metal friction were found to be functions of the intercept and slope values of cone torque versus cone index plot (r(2) = 0.94 and 0.95, respectively). Moreover, soil cohesion was found to be related to adhesion by the constrained adhesion relationship, and soil angle of internal friction was proportional to soil metal friction as reported by Hettiaratchi [7,8]. These results imply that a simpler device consisting of a rotating cone can be developed to measure soil frictional and shear characteristics. Preliminary results showed that the soil parameters determined using this device predicted the maximum net traction developed by four different radial ply tires tested by Upadhyaya et al. [18] under similar soil conditions quite well. These results indicate that the parameters obtained from the device could be useful in obtaining traction related parameters of a soil-tractive device interaction process. (C) 2010 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Garciano, Leroy Ortega; Upadhyaya, Shrinivasa K.] Univ Calif Davis, Biol & Agr Engn Dept, Davis, CA 95616 USA. [Jones, Randolph A.] USA, Corps Engineers, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Garciano, LO (reprint author), Univ Calif Davis, Biol & Agr Engn Dept, Davis, CA 95616 USA. EM logarciano@ucdavis.edu; skupad-hyaya@ucdavis.edu; Randolph.A.Jones@erdc.usace.army.mil FU US Army Research Office [W911NF-04-1-0116] FX This material is based upon work supported by the US Army Research Office under Contract/Grant Number W911NF-04-1-0116. The authors would also like to thank University of California, Davis Civil Engineering Department for the use of the universal testing machine for the laboratory tests. NR 23 TC 1 Z9 2 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD OCT PY 2010 VL 47 IS 5 BP 295 EP 305 DI 10.1016/j.jterra.2010.07.002 PG 11 WC Engineering, Environmental SC Engineering GA 659CW UT WOS:000282545600002 ER PT J AU Mansi, IA Shi, RH Khan, M Huang, JA Carden, D AF Mansi, Ishak A. Shi, Runhua Khan, Mehreen Huang, Jian Carden, Donna TI Effect of Compliance With Quality Performance Measures for Heart Failure on Clinical Outcomes in High-Risk Patients SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION LA English DT Article DE health care; heart ID PAY-FOR-PERFORMANCE; OF-CARE; UNITED-STATES; US HOSPITALS; REGISTRY; ASSOCIATION; IMPROVEMENT; MANAGEMENT; MORTALITY; MONEY AB Background: Although effects of the Joint Commission on Accreditation of Healthcare Organizations (TJC) performance measures on national trends in patient outcomes have been reported, little information exists on the effects of these quality measures on patient outcomes in individual centers caring for high-risk patient populations. Objectives: To determine the effects of compliance with TJC core quality measures for heart failure on patient outcomes at a university hospital caring for high-risk patients. Methods: We reviewed data collected for TJC in patients admitted with heart. failure at a university hospital serving an indigent population in Louisiana. Patients were divided based on compliance with TJC measures into quality-compliant or quality-deficient groups. Of 646 reviewed records, 542, representing 357 patients, were included in the analysis. There were 193 patients in the quality-compliant and 164 in the quality-deficient group. Outcome measures included rate of heart failure admission/year and readmission within 90 days. Multivariate logistic and linear regression analyses were performed to identify independent associations between patient characteristics and heart failure admission. Results: Multiple linear regression analysis demonstrated higher rates of heart failure admission/year, and multiple logistic regression revealed higher readmissions at 90 days in the quality-compliant group (parameter estimate, 0.203; p = .02; odds ratio, 2.82; 95% confidence interval, 1.46-5.44, respectively). Conclusion: Compliance with TJC quality measures for heart failure at a university hospital in Louisiana was associated with higher readmission rates for heart failure. Several factors may explain this trend, including patient characteristics and focus on national reporting benchmarks rather than patient-centered health care. C1 [Mansi, Ishak A.] Brooke Army Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. [Mansi, Ishak A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. [Shi, Runhua; Khan, Mehreen] Louisiana State Univ, Hlth Sci Ctr, Dept Med, Shreveport, LA 71105 USA. [Shi, Runhua] Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA. [Huang, Jian] Univ Calif San Francisco, Dept Med, VA Cent Calif Hlth Care Syst, San Francisco, CA USA. [Carden, Donna] Univ Florida, Coll Med, Dept Emergency Med, Gainesville, FL USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil RI Max, Mad/E-5238-2010 OI Max, Mad/0000-0001-6966-6829 NR 30 TC 11 Z9 12 U1 0 U2 1 PU NATL MED ASSOC PI WASHINGON PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA SN 0027-9684 J9 J NATL MED ASSOC JI J. Natl. Med. Assoc. PD OCT PY 2010 VL 102 IS 10 BP 898 EP 905 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 672VN UT WOS:000283615100006 PM 21053704 ER PT J AU Wall, WA Hilton, JL Wentworth, TR Gray, JB Hohmann, MG Hoffmann, WA AF Wall, Wade A. Hilton, Jacob L. Wentworth, Thomas R. Gray, Janet B. Hohmann, Matthew G. Hoffmann, William A. TI Effects of light and temperature on germination of Pyxidanthera brevifolia Wells (Diapensiaceae) SO JOURNAL OF THE TORREY BOTANICAL SOCIETY LA English DT Article DE after-ripening; conservation; Diapensiaceae; Fort Bragg Military Reservation; germination; Pyxidanthera brevifolia; Sandhills ID AMERICAN GINSENG; SELF-POLLINATION; PLANT; SEED; GROWTH; FLORA AB WALL, W. A. (Department of Plant Biology, North Carolina State University, Box 7612, Raleigh, NC 27695), J. L. HILTON (Coastal Sciences Department, University of Southern Mississippi, Hattiesburg, MS 39406), T. R. WENTWORTH (Department of Plant Biology, North Carolina State University, Box 7612, Raleigh, NC 27695), J. B. GRAY (Endangered Species Branch, Fort Bragg, NC 28310), M. G. HOHMANN (US Army Corps of Engineers, Engineer Research and Development Center, Box 9005, Champaign, IL 61826), and W. A. HOFFMANN (Department of Plant Biology, North Carolina State University, Box 7612, Raleigh, NC 27695). Effects of light and temperature on germination of Pyxidanthera brevifolia B.W. Wells (Diapensiaceae). J. Torrey Bot. Soc. 137: 348-354. 2010.-Pyxidanthera brevifolia is an evergreen semi-woody cushion plant endemic to the Sandhills of North and South Carolina, with the majority of populations occurring on Fort Bragg Military Reservation in North Carolina. Currently the species is listed as Endangered in North Carolina and is designated as a Species at Risk (SAR) by the US Department of Defense. Previous studies have suggested that seeds may not be viable because they failed to germinate under controlled conditions. Our objectives in this study were to attempt germination of Pyxidanthera brevifolia seeds, determine the best temperature conditions for germination, and understand more about germination requirements to aid in future restoration efforts. Using seeds that had been stored at room temperature for six months, we performed a germination experiment at the NCSU Phytotron with six treatments, all combinations of three temperature regimes (low (18 degrees C day / 14 degrees C night), medium (22/18 degrees C), and high (26/22 degrees C)) and two light conditions (light and dark). We monitored the experiment for 13 weeks, recording the number of seeds germinating per dish and the number of days to germination for seeds in each treatment. We found that Pxyidanthera brevifolia produces germinable seeds and that there are significant effects of light and temperature on germination. Highest germination occurred under low temperature and high light conditions (78%); the combination of high temperature and no light produced the lowest germination (6%). Seeds exposed to light germinated significantly earlier at the coolest temperature, compared to medium and high temperatures. These results indicate that it is possible to germinate seeds of this rare plant and suggest that germination of Pyxidanthera brevifolia likely occurs in late fall and is dependent on adequate light availability. C1 [Wall, Wade A.; Wentworth, Thomas R.; Hoffmann, William A.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA. [Hilton, Jacob L.] Univ So Mississippi, Coastal Sci Dept, Hattiesburg, MS 39406 USA. [Gray, Janet B.] Endangered Species Branch, Ft Bragg, NC 28310 USA. [Hohmann, Matthew G.] USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Wall, WA (reprint author), N Carolina State Univ, Dept Plant Biol, Box 7612, Raleigh, NC 27695 USA. EM wade.wall@gmail.com RI Hoffmann, William/E-8894-2010 OI Hoffmann, William/0000-0002-1926-823X FU Department of Defense, US Army Engineer Research and Development Center, Construction Engineering Research Laboratory [W9132T-07-2-0019] FX Funding was provided by Department of Defense, US Army Engineer Research and Development Center, Construction Engineering Research Laboratory under Agreement # W9132T-07-2-0019. NR 40 TC 1 Z9 1 U1 1 U2 10 PU TORREY BOTANICAL SOC PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 USA SN 1095-5674 J9 J TORREY BOT SOC JI J. Torrey Bot. Soc. PD OCT-DEC PY 2010 VL 137 IS 4 BP 348 EP 354 DI 10.3159/10-RA-023.1 PG 7 WC Plant Sciences SC Plant Sciences GA 719RE UT WOS:000287225600005 ER PT J AU Svetlov, SI Prima, V Kirk, DR Gutierrez, H Curley, KC Hayes, RL Wang, KKW AF Svetlov, Stanislav I. Prima, Victor Kirk, Daniel R. Gutierrez, Hector Curley, Kenneth C. Hayes, Ronald L. Wang, Kevin K. W. TI Morphologic and Biochemical Characterization of Brain Injury in a Model of Controlled Blast Overpressure Exposure SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Blast; Brain injury; Experimental models; Biomarkers; UCH-L1; GFAP; CNPase ID NEURON-SPECIFIC ENOLASE; ALPHA-II-SPECTRIN; INDUCED NEUROTRAUMA; TERMINAL HYDROLASE; SILVER TECHNIQUE; UP-REGULATION; RAT-BRAIN; SERUM; DEGENERATION; BIOMARKERS AB Objectives: Existing experimental approaches for studies of blast impact in small animals are insufficient and lacking consistency. Here, we present a comprehensive model, with repeatable blast signatures of controlled duration, peak pressure, and transmitted impulse, accurately reproducing blast impact in laboratory animals. Materials: Rat survival, brain pathomorphology, and levels of putative biomarkers of brain injury glial fibrillary acid protein (GFAP), neuron-specific enolase, and ubiquitin C-terminal hydrolase (UCH)-L1 were examined in brain, cerebrospinal fluid (CSF), and blood after 10 msec of 358 kPa peak overpressure blast exposure. Results: The high-speed imaging demonstrated a strong head acceleration/jolting accompanied by typical intracranial hematomas and brain swelling. Microscopic injury was revealed by prominent silver staining in deep brain areas, including the nucleus subthalamicus zone, suggesting both diffused and focal neurodegeneration. GFAP and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), markers of astroglia and oligodendroglia, accumulated substantially in the hippocampus 24 hours after blast and persisted for 30 days postblast. However, GFAP content in the blood significantly increased 24 hours after injury, followed by a decline and subsequent accumulation in CSF in a time-dependent fashion. A similar profile is shown for UCH-L1 increase in blood, whereas increased CSF levels of UCH-L1 persisted throughout 14 days after blast and varied significantly in individual rats. Neuron-specific enolase levels in blood were significantly elevated within 24 hours and 48 hours postblast. Conclusions: The proposed model of controlled nonpenetrating blast in rats demonstrates the critical pathologic and biochemical signatures of blast brain injury that may be triggered by cerebrovascular responses, including blood-brain barrier disruption, glia responses, and neuroglial alterations. C1 [Svetlov, Stanislav I.; Prima, Victor; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL 32615 USA. [Kirk, Daniel R.; Gutierrez, Hector] Florida Inst Technol, Dept Mech & Aerosp Engn, Melbourne, FL 32901 USA. [Svetlov, Stanislav I.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. [Curley, Kenneth C.] USA, Med Res & Mat Command MRMC, Frederick, MD USA. RP Svetlov, SI (reprint author), Banyan Biomarkers Inc, Ctr Innovat Res, 12085 Res Dr, Alachua, FL 32615 USA. EM ssvetlov@banyanbio.com OI Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [N14-06-1-1029, W81XWH-8-1-0376, W81XWH-07-01-0701] FX Supported by Department of Defense grants N14-06-1-1029, W81XWH-8-1-0376, and W81XWH-07-01-0701. NR 57 TC 96 Z9 99 U1 0 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2010 VL 69 IS 4 BP 795 EP 804 DI 10.1097/TA.0b013e3181bbd885 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 664KP UT WOS:000282959100026 PM 20215974 ER EF