FN Thomson Reuters Web of Science™ VR 1.0 PT J AU McGeary, D Moore, M Vriend, CA Peterson, AL Gatchel, RJ AF McGeary, Don Moore, Mysti Vriend, Catherine A. Peterson, Alan L. Gatchel, Robert J. TI The Evaluation and Treatment of Comorbid Pain and PTSD in a Military Setting: An Overview SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Article DE Comorbidity; Functional restoration; Pain; Post-traumatic stress disorder (PTSD); Disability ID POSTTRAUMATIC-STRESS-DISORDER; OPERATION-IRAQI-FREEDOM; ENDURING-FREEDOM; SYMPTOMS; PREVALENCE; DISABILITY; CASUALTIES; PERSONNEL; INJURIES; TRAUMA AB The present article reviews the growing prevalence of comorbid pain and post-traumatic stress disorder (PTSD) in the military. This has been caused by the ongoing military conflicts in Iraq and Afghanistan, where new combat conditions/strategies are causing these comorbid conditions. Fortunately, comprehensive interdisciplinary treatment programs, originally developed for a civilian population and in academic settings, are being successfully "translated" or utilized in the military environment. Recent data demonstrating this translational clinical intervention are presented. Finally, challenges encountered when translating these interventions in a military environment are also discussed. C1 [Moore, Mysti; Gatchel, Robert J.] Univ Texas Arlington, Dept Psychol, Coll Sci, Arlington, TX 76019 USA. [McGeary, Don] Wilford Hall USAF Med Ctr, Clin Hlth Psychol Serv, San Antonio, TX 78236 USA. [Vriend, Catherine A.] Brooke Army Med Ctr, Dept Behav Med, San Antonio, TX USA. [Peterson, Alan L.] UT Hlth Sci Ctr San Antonio, Sch Med, San Antonio, TX USA. RP Gatchel, RJ (reprint author), Univ Texas Arlington, Dept Psychol, Coll Sci, 313 Life Sci Bldg, Arlington, TX 76019 USA. EM gatchel@uta.edu NR 30 TC 16 Z9 16 U1 1 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD JUN PY 2011 VL 18 IS 2 BP 155 EP 163 DI 10.1007/s10880-011-9236-5 PG 9 WC Psychology, Clinical SC Psychology GA 775SQ UT WOS:000291484100006 PM 21626356 ER PT J AU Stetz, MC Folen, RA Yamanuha, BK AF Stetz, Melba C. Folen, Raymond A. Yamanuha, Bronson K. TI Technology Complementing Military Behavioral Health Efforts at Tripler Army Medical Center SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Article DE Stress; Virtual reality; Telehealth ID MENTAL-HEALTH; PERFORMANCE; STRESS AB The purpose of this article is to provide a short narrative on the ways that behavioral health professionals and their patients are currently benefitting from the use of technology. Examples stem from applications of technology to patients/research participants at the Tripler Army Medical Center. The paper also discusses how current use of this technology has made it possible to serve individuals in their own cultural environment, providing a cost-effective means of providing mental health services. C1 [Stetz, Melba C.; Folen, Raymond A.; Yamanuha, Bronson K.] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. RP Stetz, MC (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM melba.stetz@us.army.mil RI Schueter, nicos/A-3625-2014 NR 35 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD JUN PY 2011 VL 18 IS 2 BP 188 EP 195 DI 10.1007/s10880-011-9246-3 PG 8 WC Psychology, Clinical SC Psychology GA 775SQ UT WOS:000291484100009 PM 21643963 ER PT J AU Melamed, BG Castro, C AF Melamed, Barbara G. Castro, Carl TI Observations and Insights About Strengthening Our Soldiers (SOS) SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Editorial Material DE PTSD; Traumatic brain injury; Polytrauma; Chronic pain; Prolonged exposure; Cognitive processing; Virtual reality; Suicide; Alcoholism; War trauma; Soldiers; Veterans ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; CHRONIC PAIN; US-ARMY; MUTUAL MAINTENANCE; FUNCTIONAL MRI; ALCOHOL-USE; IRAQ; AFGHANISTAN AB The Special Issue (June 2011) of the Journal of Clinical Psychology in Medical Settings titled Strengthening Our Soldiers (SOS) and Their Families: Contemporary Psychological Advances Applied to Wartime Problems revealed the following important concerns: 1) Who is at risk for psychological sequelae during and following service in the U.S. military? 2) How to deliver the best treatment for our soldiers and veterans with PTSD, Traumatic Brain Injury and Pain? 3) How to train the trainers? and 4) What are the current priorities for service delivery, research and funding? Assessment strategies and tools are provided to assist in identification of suicidal ideation and behaviors, alcohol abuse in spouses, posttraumatic stress disorders, depression, brain injuries and post-concussion syndrome, as well as positive growth experiences. Empirically validated Cognitive Processing and Prolonged Exposure treatments are described as are the empirical results already in evidence in our military populations. The innovative use of Virtual Reality and Telehealth applications is demonstrated in both army and naval settings for preparing and reducing trauma in affected soldiers. The Functional and Occupational Rehabilitation Treatment (FORT) Program and its role in returning function to injured soldiers with musculoskeletal pain and motion restrictions, while also leading to reductions of anxiety, depression and use of medical services, is described. A critique about providing service-research for children's reactions to their parent's deployments and family functioning during separation and reintegration is provided. The need for theoretical-empirical approaches to understanding pain-behavior, anxiety dysregulation as it impacts the brain function and structure is provided by experts in pain, neuropsychology, brain circuitry and anxiety management of multiple traumas. This final paper in SOS provides commentary on SOS and describes possible future implications of current psychological knowledge related to military personnel and their families. C1 [Melamed, Barbara G.] Tripler Army Med Ctr, Dept Psychol, Clin Heath Psychol Postdoctoral Fellowship Progra, Honolulu, HI 96859 USA. [Castro, Carl] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Melamed, BG (reprint author), Univ Hawaii, Dept Psychol, Clin Studies Program, 2530 Dole St, Honolulu, HI 96822 USA. EM bmelamed@hawaii.edu RI Duncan, Kirsty/H-1911-2011; Schueter, nicos/A-3625-2014 NR 79 TC 0 Z9 0 U1 2 U2 20 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD JUN PY 2011 VL 18 IS 2 BP 210 EP 223 DI 10.1007/s10880-011-9253-4 PG 14 WC Psychology, Clinical SC Psychology GA 775SQ UT WOS:000291484100015 PM 21638114 ER PT J AU Furey, JS Butler, DK AF Furey, John S. Butler, Dwain K. TI The Physical Dipole Model and Polarizability for Magnetostatic Object Parameter Estimation SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article ID DEMAGNETIZING FACTORS; UNEXPLODED ORDNANCE; FIELDS; UXO; MAGNETIZATION; CYLINDERS; BARS AB The physical dipole is the next simplest model of a magnetic object beyond the point dipole model. The theory and analytical properties of the physical dipole are developed and explored, and compare favorably with alternative models, including limiting cases of prolate spheroids and other shapes. The general applicability of explicitly modeling the demagnetization properties of magnetic materials is critically reviewed, and reasons proffered to use the object polarizability instead, especially for the external field properties of most relevance. Neither the physical dipole model nor polarizability is currently used for magnetostatic parameter estimation of magnetic objects such as unexploded ordnance. It is recommended that their utility be further explored with field data. C1 [Furey, John S.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Butler, Dwain K.] Appl Geophys Consultancy LLC, Vicksburg, MS 39180 USA. RP Furey, JS (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.s.furey@usace.army.mil FU U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS FX This research was supported by the U.S. Army Engineer Environmental Quality and Installations Program at the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS. The use of the extensive U.S. Army Environmental Quality Technology (EQT) Research compendium of UXO reports and articles, available through the EQT Program Management Office at ERDC, is gratefully acknowledged. NR 54 TC 1 Z9 1 U1 1 U2 4 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD JUN PY 2011 VL 16 IS 2 BP 49 EP 60 PG 12 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 775YZ UT WOS:000291501000001 ER PT J AU Barrett, AH Porter, WL Marando, G Chinachoti, P AF Barrett, Ann H. Porter, William L. Marando, Gina Chinachoti, Pavinee TI EFFECT OF VARIOUS ANTIOXIDANTS, ANTIOXIDANT LEVELS, AND ENCAPSULATION ON THE STABILITY OF FISH AND FLAXSEED OILS: ASSESSMENT BY FLUOROMETRIC ANALYSIS SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID IN-WATER EMULSIONS; OXIDATIVE STABILITY; BULK OILS; ASCORBYL PALMITATE; ALPHA-TOCOPHEROL; ROSEMARY EXTRACT; LIPID OXIDATION; CITRIC-ACID; EDTA AB Ease of use and oxidative stability of fish and flaxseed oils were improved by encapsulation and antioxidants. The oils, containing various levels of vitamin E, rosmarinic acid, ethylenediaminetetraacetic acid and citric acid, plus carnosic acid and ascorbyl palmitate for fish oil, were encapsulated and tested weekly for 8 weeks by a front-face ratiometric fluorometric method applied to both powders and volatile-reacting polyamide plates. Regression analysis of fluorescence ratio versus time was used to calculate induction times and oxidation rate; significance of inhibition was additionally determined at each pull. Encapsulation increased the stability of both oils, most significantly for flaxseed oil. Encapsulated fish oil stability was increased by all antioxidants, most significantly by carnosic acid. Encapsulated unsupplemented flaxseed oil was more stable than fish oil, but its stability was diminished by most antioxidants. Sensory properties of high-carbohydrate performance bars supplemented with the encapsulated oils were comparable with those of an unsupplemented control. PRACTICAL APPLICATIONS Fortification of foods with omega-3 fatty acid-containing fish and flaxseed oils would improve nutritional quality through provision of docosahexaenoic acid, eicosapentaenoic acid, and alpha-linolenic acid. The oils in their native state not only lack functionality (i.e., are not suitable for addition to dry foods), but also are not shelf-stable because of their susceptibility to oxidation. Incorporation of the oils into a high-load powder through encapsulation produces an easily added ingredient for fortification; incorporation of effective antioxidants at optimal levels ensures oxidative shelf stability. Analysis of the encapsulated oils over several weeks and at high storage temperatures can indicate best antioxidants and concentrations to incorporate into long shelf-life food. C1 [Barrett, Ann H.; Porter, William L.; Marando, Gina] USA, Performance Optimizat Res Team, Combat Feeding Directorate, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. [Chinachoti, Pavinee] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA. RP Barrett, AH (reprint author), USA, Performance Optimizat Res Team, Combat Feeding Directorate, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. EM ann.barrett@us.army.mil NR 31 TC 11 Z9 11 U1 2 U2 38 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0145-8892 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD JUN PY 2011 VL 35 IS 3 BP 349 EP 358 DI 10.1111/j.1745-4549.2009.00474.x PG 10 WC Food Science & Technology SC Food Science & Technology GA 774PQ UT WOS:000291399000009 ER PT J AU Khattab, MA Ferenci, P Hadziyannis, SJ Colombo, M Manns, MP Almasio, PL Esteban, R Abdo, AA Harrison, SA Ibrahim, N Cacoub, P Eslam, M Lee, SS AF Khattab, Mahmoud A. Ferenci, Peter Hadziyannis, Stephanos J. Colombo, Massimo Manns, Michael P. Almasio, Piero L. Esteban, Rafael Abdo, Ayman A. Harrison, Stephen A. Ibrahim, Nazir Cacoub, Patrice Eslam, Mohammed Lee, Samuel S. TI Management of hepatitis C virus genotype 4: Recommendations of An International Expert Panel SO JOURNAL OF HEPATOLOGY LA English DT Review ID SUSTAINED VIROLOGICAL RESPONSE; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; CHRONIC LIVER-DISEASE; CD4(+) T-CELL; HEPATOCELLULAR-CARCINOMA; PEGINTERFERON ALPHA-2A; EGYPTIAN PATIENTS; PEGYLATED INTERFERON; COMBINATION THERAPY; INITIAL TREATMENT AB HCV has been classified into no fewer than six major genotypes and a series of subtypes. Each HCV genotype is unique with respect to its nucleotide sequence, geographic distribution, and response to therapy. Genotypes 1, 2, and 3 are common throughout North America and Europe. HCV genotype 4 (HCV-4) is common in the Middle East and in Africa, where it is responsible for more than 80% of HCV infections. It has recently spread to several European countries. HCV-4 is considered a major cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma, and liver transplantation in these regions. Although HCV-4 is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in the world, it has not been the subject of widespread research. Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Khattab, Mahmoud A.; Eslam, Mohammed] Univ Minia, Dept Internal Med, Al Minya 61111, Egypt. [Ferenci, Peter] Med Univ, Dept Internal Med 3, Vienna, Austria. [Hadziyannis, Stephanos J.] Henry Dunant Hosp, Athens, Greece. [Colombo, Massimo] Univ Milan, Div Gastroenterol 1, Dept Med, Fdn IRCCS,Osped Maggiore Policlin, Milan, Italy. [Manns, Michael P.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany. [Almasio, Piero L.] Univ Palermo, Gastroenterol & Hepatol Unit, DiBiMIS, Palermo, Italy. [Esteban, Rafael] Hosp Gen Univ Valle Hebron, Liver Unit, Barcelona, Spain. [Abdo, Ayman A.] King Saud Univ, Coll Med, Gastroenterol Unit, Riyadh 11461, Saudi Arabia. [Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. [Ibrahim, Nazir] Al Kalamoon Univ, Dept Gastroenterol Hepatol, Damascus, Syria. [Cacoub, Patrice] Univ Paris 06, Hop Pitie Salpetriere, AP HP,Serv Med Interne 2, UMR 7211,UPMC CNRS,U 959,INSERM, F-75013 Paris, France. [Lee, Samuel S.] Univ Calgary, Liver Unit, Calgary, AB, Canada. RP Khattab, MA (reprint author), Univ Minia, Dept Internal Med, Al Minya 61111, Egypt. EM mkhattabmed@hotmail.com NR 144 TC 73 Z9 75 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 J9 J HEPATOL JI J. Hepatol. PD JUN PY 2011 VL 54 IS 6 BP 1250 EP 1262 DI 10.1016/j.jhep.2010.11.016 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 776GR UT WOS:000291523000024 PM 21316497 ER PT J AU Zeweldi, DA Gebremichael, M Downer, CW AF Zeweldi, Dawit A. Gebremichael, Mekonnen Downer, Charles W. TI On CMORPH Rainfall for Streamflow Simulation in a Small, Hortonian Watershed SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID PRECIPITATION PRODUCTS; OKAVANGO RIVER; MODELS; BASIN; CALIBRATION; PREDICTION; RUNOFF; GAUGE AB The objective is to assess the use of the Climate Prediction Center morphing method (CMORPH) (similar to 0.073 degrees latitude-longitude, 30 min resolution) rainfall product as input to the physics-based fully distributed Gridded Surface-Subsurface Hydrologic Analysis (GSSHA) model for streamflow simulation in the small (21.4 km(2)) Hortonian watershed of the Goodwin Creek experimental watershed located in northern Mississippi. Calibration is performed in two different ways: using rainfall data from a dense network of 30 gauges as input, and using CMORPH rainfall data as input. The study period covers 4 years, during which there were 24 events, each with peak flow rate higher than 0.5 m(3) s(-1). Streamflow simulations using CMORPH rainfall are compared against observed streamflows and streamflow simulations using rainfall from a dense rain gauge network. Results show that the CMORPH simulations captured all 24 events. The CMORPH simulations have comparable performance with gauge simulations, which is striking given the significant differences in the spatial scale between the rain gauge network and CMORPH. This study concludes that CMORPH rainfall products have potential value for streamflow simulation in such small watersheds. Overall, the performance of CMORPH-driven simulations increases when the model is calibrated with CMORPH data than when the model is calibrated with rain gauge data. C1 [Gebremichael, Mekonnen] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Downer, Charles W.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Gebremichael, M (reprint author), Univ Connecticut, Dept Civil & Environm Engn, 261 Glenbrook Rd,Unit 2037, Storrs, CT 06269 USA. EM mekonnen@engr.uconn.edu FU NASA [NNX08AR31G, NNX10AG77G] FX The study was supported by NASA NIP Grant NNX08AR31G and NASA Grant NNX10AG77G to the University of Connecticut. NR 24 TC 7 Z9 7 U1 0 U2 4 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD JUN PY 2011 VL 12 IS 3 BP 456 EP 466 DI 10.1175/2010JHM1270.1 PG 11 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 777AF UT WOS:000291584300008 ER PT J AU Rasmussen, TE AF Rasmussen, Todd E. TI Characterization of Systemic and Histologic Injury After Crush Syndrome and Intervals of Reperfusion in a Small Animal Model EDITORIAL COMMENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2011 VL 70 IS 6 BP 1463 EP 1463 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 775QR UT WOS:000291478500033 ER PT J AU Rasmussen, TE AF Rasmussen, Todd E. TI Prolonged Indwelling Time of Temporary Vascular Shunts Is Associated With Increased Endothelial Injury in the Porcine Mesenteric Artery EDITORIAL COMMENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2011 VL 70 IS 6 BP 1469 EP 1470 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 775QR UT WOS:000291478500035 ER PT J AU Ou, W Delisle, J Konduru, K Bradfute, S Radoshitzky, SR Retterer, C Kota, K Bavari, S Kuhn, JH Jahrling, PB Kaplan, G Wilson, CA AF Ou, Wu Delisle, Josie Konduru, Krishnamurthy Bradfute, Steven Radoshitzky, Sheli R. Retterer, Cary Kota, Krishna Bavari, Sina Kuhn, Jens H. Jahrling, Peter B. Kaplan, Gerardo Wilson, Carolyn A. TI Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Ebola; Ebolavirus; Envelope glycoprotein; Filovirus; sGP ID VIRUS INFECTION; MONOCLONAL-ANTIBODIES; PASSIVE TRANSFER; EPITOPES; ELISA; CELL; GP AB Ebolaviruses are the etiologic agents of severe viral hemorrhagic fevers in primates, including humans, and could be misused for the development of biological weapons. The ability to rapidly detect and differentiate these viruses is therefore crucial. Antibodies that can detect reliably the ebolavinis surface envelope glycoprotein GP(1,2) or a truncated variant that is secreted from infected cells (sGP) are required for advanced development of diagnostic assays such as sandwich ELISAs or Western blots (WB). We used a GP(1,2) peptide conserved among Bundibugyo, Ebola, Reston, Sudan, and Tai Forest viruses and a mucin-like domain-deleted Sudan virus GP(1,2) (SudanGP Delta Muc) to immunize mice or rabbits, and developed a panel of antibodies that either cross-react or are virus-specific. These antibodies detected full-length GP(1,2) and sGP in different assays such as ELISA, FACS, or WB. In addition, some of the antibodies were shown to have potential clinical relevance, as they detected ebolavirus-infected cells by immunofluorescence assay and gave a specific increase in signal by sandwich ELISA against sera from mouse-adapted Ebola virus-infected mice over uninfected mouse sera. Rabbit anti-SudanGP Delta Muc polyclonal antibody neutralized gammaretroviral particles pseudotyped with Sudan virus GP(1,2), but not particles pseudotyped with other ebolavirus GP(1,2). Together, our results suggest that this panel of antibodies may prove useful for both in vitro analyses of ebolavirus GP(1,2), as well as analysis of clinically relevant samples. Published by Elsevier B.V. C1 [Ou, Wu; Delisle, Josie; Wilson, Carolyn A.] US FDA, Div Cellular & Gene Therapies, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Konduru, Krishnamurthy; Kaplan, Gerardo] US FDA, Div Emerging & Transfus Transmitted Dis, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Bradfute, Steven; Radoshitzky, Sheli R.; Retterer, Cary; Kota, Krishna; Bavari, Sina] USA, Med Res Inst Infect Dis, Div Toxicol, Frederick, MD USA. [Kuhn, Jens H.; Jahrling, Peter B.] NIH NIAID Integrated Res Facil Ft Detrick, Frederick, MD USA. RP Wilson, CA (reprint author), US FDA, Div Cellular & Gene Therapies, Ctr Biol Evaluat & Res, Bldg 29B,Room 5NN22,8800 Rockville Pike, Bethesda, MD 20892 USA. EM carolyn.wilson@fda.hhs.gov RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU CBER/NIAID Interagency Agreement (IAG); Biomedical Advanced Research and Development Authority (BARDA); Joint Science and Technology Office Transformational Medical Technologies [TMT10048_09_RD_T]; Defense Threat Reduction Agency [4.10022_08_RD_B]; NIAID [HHSN2722002000161] FX We are grateful to Seton Pariser, Bertram W. Maidment III, and Evan Ewers for their technical assistance. This research was partially supported by CBER/NIAID Interagency Agreement (IAG) and the Biomedical Advanced Research and Development Authority (BARDA). This research was partially supported by the Joint Science and Technology Office Transformational Medical Technologies (proposal # TMT10048_09_RD_T) and Defense Threat Reduction Agency (proposal #4.10022_08_RD_B) to SB. JHK performed this work as an employee of Tunnel(Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN2722002000161. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army, the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 25 TC 5 Z9 7 U1 4 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD JUN PY 2011 VL 174 IS 1-2 BP 99 EP 109 DI 10.1016/j.jviromet.2011.04.003 PG 11 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 776FX UT WOS:000291521000016 PM 21513741 ER PT J AU De Lucia, FC Gottfried, JL AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. TI Rapid analysis of energetic and geo-materials using LIBS SO MATERIALS TODAY LA English DT Article ID LASER-INDUCED-BREAKDOWN; INDUCED PLASMA SPECTROSCOPY; PARTIAL LEAST-SQUARES; QUANTITATIVE-ANALYSIS; SPECTROCHEMICAL ANALYSIS; PATTERN-RECOGNITION; ELEMENTAL ANALYSIS; SENSOR TECHNOLOGY; REAL-TIME; SAMPLES AB The laser induced breakdown spectroscopy (LIBS) technique has been used to analyze a diverse array of materials for several decades. LIBS is ideal for rapid materials analysis since data can be collected in real time with no sample preparation. The coupling of LIBS with multivariate analysis has increased in recent years and allows for rapid processing of spectral information for qualitative or quantitative analysis. We will discuss several examples of how LIBS and multivariate analysis has been used to classify geological and energetic materials at the United States Army Research Laboratory. It is important to understand the parameters that influence the results and the limitations of multivariate analysis for LIBS applications. C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM frank.delucia@us.army.mil RI De Lucia, Frank/D-5630-2012; Gottfried, Jennifer/G-6333-2010 NR 90 TC 12 Z9 12 U1 5 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1369-7021 J9 MATER TODAY JI Mater. Today PD JUN PY 2011 VL 14 IS 6 BP 274 EP 281 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 774ZW UT WOS:000291426700018 ER PT J AU Owens, BD Duffey, ML DeBerardino, TM Cameron, KL AF Owens, Brett D. Duffey, Michele L. DeBerardino, Thomas M. Cameron, Kenneth L. TI Physical Examination Findings in Young Athletes Correlate With History of Shoulder Instability SO ORTHOPEDICS LA English DT Article ID GENERALIZED JOINT HYPERMOBILITY; UNITED-STATES; TESTS AB The goal of this study was to evaluate physical examination findings in a healthy cohort and determine potential correlations with a history of shoulder instability. A cross-sectional analysis was performed using the baseline data for an ongoing prospective cohort study to examine the risk factors for shoulder instability. A complete history of shoulder instability events was obtained, and a blinded physical examination was performed. The cohort comprised 711 patients (627 men, 84 women) with a mean age of 18.8 years. A total of 100 patients had a history of shoulder instability. Patients with a history of instability were more likely to have increased posterior translation (P=.010), positive apprehension sign (P=.003), positive relocation sign (P=.007), and sulcus sign (P=.017). C1 [Owens, Brett D.; Cameron, Kenneth L.] Keller Army Hosp, West Point, NY 10996 USA. [Duffey, Michele L.] Penn State Univ, Dept Kinesiol, State Coll, PA USA. [DeBerardino, Thomas M.] Univ Connecticut, Ctr Hlth, Dept Orthoped Surg, Farmington, CT USA. RP Owens, BD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743; Cameron, Kenneth/0000-0002-6276-4482 FU Orthopaedic Research and Education Foundation FX Drs Owens, DeBerardino, and Cameron, and Ms Duffey have no relevant financial relationships to disclose. This project was aided by a grant from the Orthopaedic Research and Education Foundation. NR 14 TC 7 Z9 7 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUN PY 2011 VL 34 IS 6 BP 460 EP 464 DI 10.3928/01477447-20110427-21 PG 5 WC Orthopedics SC Orthopedics GA 776GG UT WOS:000291521900024 PM 21661678 ER PT J AU Cersovsky, SB AF Cersovsky, Steven B. TI Fighting the War Within: Suicide as an Individual and Public Health Challenge in the US Army SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Editorial Material C1 [Cersovsky, Steven B.] USA, Med Corps, Washington, DC USA. [Cersovsky, Steven B.] USA, Publ Hlth Command, Washington, DC USA. RP Cersovsky, SB (reprint author), 5158 Blackhawk Rd, Aberdeen Proving Ground, MD USA. EM steven.cersovsky@us.army.mil NR 3 TC 2 Z9 2 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SUM PY 2011 VL 74 IS 2 BP 110 EP 114 PG 5 WC Psychiatry SC Psychiatry GA 776UR UT WOS:000291564400003 PM 21688959 ER PT J AU Warner, CH Appenzeller, GN Parker, JR Warner, C Diebold, CJ Grieger, T AF Warner, Christopher H. Appenzeller, George N. Parker, Jessica R. Warner, Carolynn Diebold, Carroll J. Grieger, Thomas TI Suicide Prevention in a Deployed Military Unit SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Article ID DIVISION MENTAL-HEALTH; COMBAT TEAM STRUCTURE; RISK; SURVEILLANCE; PROGRAM; STATES; MODEL; CARE AB Objective: Military suicide and parasuicidal behaviors have been increasing over the last several years, with rates highest in the deployed environment. This article presents a deployment cycle-specific suicide prevention plan utilized during one U.S. Army division's 15-month deployment to Iraq. Methods: Education, identification, and intervention programs were implemented at each phase of the deployment cycle based on the specific unit activities and predicted stressors. Results: During the deployment, there was an annual suicide rate of 16/100,000 within the trial cohort, compared to a theater rate of 24/100,000. Peaks in suicidal ideation and behaviors occurred during months two, six, and twelve of deployment. Conclusions: A deployment cycle prevention program may decrease rates of suicide in the combat environment. This program may serve as a model for other suicide prevention programs. C1 [Warner, Christopher H.] USA Commander & Gen Staff Coll, Ft Leavenworth, KS USA. [Appenzeller, George N.] Bassett Army Community Hosp, Ft Wainwright, AK USA. [Parker, Jessica R.] Winn Army Community Hosp, Warrior Restorat Ctr, Ft Stewart, GA USA. [Diebold, Carroll J.] Triplet Army Med Ctr, Dept Psychiat, Honolulu, HI USA. [Grieger, Thomas] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. RP Warner, CH (reprint author), USA Commander & Gen Staff Coll, Ft Leavenworth, KS USA. NR 36 TC 6 Z9 6 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SUM PY 2011 VL 74 IS 2 BP 127 EP 141 PG 15 WC Psychiatry SC Psychiatry GA 776UR UT WOS:000291564400008 PM 21688964 ER PT J AU Morey, LC Lowmaster, SE Coldren, RL Kelly, MP Parish, RV Russell, ML AF Morey, Leslie C. Lowmaster, Sara E. Coldren, Rodney L. Kelly, Mark P. Parish, Robert V. Russell, Michael L. TI Personality Assessment Inventory Profiles of Deployed Combat Troops: An Empirical Investigation of Normative Performance SO PSYCHOLOGICAL ASSESSMENT LA English DT Article DE Personality Assessment Inventory; assessment; military psychology; combat stress ID POSTTRAUMATIC-STRESS-DISORDER; VETERANS; PTSD; IRAQ; PAI; AFGHANISTAN; VALIDITY; SCALES AB The present study examined the normative scores and psychometric properties of the Personality Assessment Inventory (PAI; Morey, 1991) within a non-treatment-seeking sample of soldiers deployed to combat zones in Iraq, compared with a sample of community adults matched with respect to age and gender. Results indicate the scores and properties of the PAI scales were generally quite similar in the Iraq and community samples, with modest differences emerging on only 3 subscales addressing antisocial behavior, issues with close relationships, and interpersonal vigilance. These results suggest that standard normative interpretation of PAI scales is appropriate even when the instrument is administered in a combat zone. In comparison with prior research, the results may suggest that documented mental health issues among combat veterans, when present, may be particularly likely to emerge postdeployment. C1 [Morey, Leslie C.; Lowmaster, Sara E.] Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA. [Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Kelly, Mark P.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC USA. [Parish, Robert V.] Landstuhl Reg Med Ctr, Dept Behav Hlth, Landstuhl, Germany. [Russell, Michael L.] USA, HQ, Med Command, Ft Sam Houston, TX USA. RP Morey, LC (reprint author), Texas A&M Univ, Dept Psychol, MS 4235, College Stn, TX 77843 USA. EM lmorey@psych.tamu.edu RI Morey, Leslie/B-5617-2008 OI Morey, Leslie/0000-0001-7711-5568 NR 24 TC 5 Z9 5 U1 0 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1040-3590 J9 PSYCHOL ASSESSMENT JI Psychol. Assess. PD JUN PY 2011 VL 23 IS 2 BP 456 EP 462 DI 10.1037/a0022173 PG 7 WC Psychology, Clinical SC Psychology GA 774HY UT WOS:000291377500016 PM 21319909 ER PT J AU Bahn, RS Burch, HB Cooper, DS Garber, JR Greenlee, MC Klein, I Laurberg, P McDougall, IR Montori, VM Rivkees, SA Ross, DS Sosa, JA Stan, MN AF Bahn, Rebecca S. Burch, Henry B. Cooper, David S. Garber, Jeffrey R. Greenlee, M. Carol Klein, Irwin Laurberg, Peter McDougall, I. Ross Montori, Victor M. Rivkees, Scott A. Ross, Douglas S. Sosa, Julie Ann Stan, Marius N. TI Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists SO THYROID LA English DT Article ID ENDOGENOUS SUBCLINICAL HYPERTHYROIDISM; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY; AMIODARONE-INDUCED THYROTOXICOSIS; PERCUTANEOUS ETHANOL INJECTION; HUMAN CHORIONIC-GONADOTROPIN; DRUG-INDUCED AGRANULOCYTOSIS; RADIOACTIVE IODINE THERAPY; MULTINODULAR TOXIC GOITER; QUALITY-OF-LIFE; PARATHYROID-HORMONE ASSAY AB Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition. Methods: The development of these guidelines was commissioned by the American Thyroid Association in association with the American Association of Clinical Endocrinologists. The American Thyroid Association and American Association of Clinical Endocrinologists assembled a task force of expert clinicians who authored this report. The task force examined relevant literature using a systematic PubMed search supplemented with additional published materials. An evidence-based medicine approach that incorporated the knowledge and experience of the panel was used to develop the text and a series of specific recommendations. The strength of the recommendations and the quality of evidence supporting each was rated according to the approach recommended by the Grading of Recommendations, Assessment, Development, and Evaluation Group. Results: Clinical topics addressed include the initial evaluation and management of thyrotoxicosis; management of Graves' hyperthyroidism using radioactive iodine, antithyroid drugs, or surgery; management of toxic multinodular goiter or toxic adenoma using radioactive iodine or surgery; Graves' disease in children, adolescents, or pregnant patients; subclinical hyperthyroidism; hyperthyroidism in patients with Graves' ophthalmopathy; and management of other miscellaneous causes of thyrotoxicosis. Conclusions: One hundred evidence-based recommendations were developed to aid in the care of patients with thyrotoxicosis and to share what the task force believes is current, rational, and optimal medical practice. C1 [Bahn, Rebecca S.; Montori, Victor M.; Stan, Marius N.] Mayo Clin, Div Endocrinol Metab & Nutr, Rochester, MN 55905 USA. [Burch, Henry B.] Walter Reed Army Med Ctr, Div Endocrinol & Metab, Washington, DC 20307 USA. [Cooper, David S.] Johns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD USA. [Garber, Jeffrey R.] Harvard Vanguard Med Associates, Div Endocrine, Boston, MA USA. [Greenlee, M. Carol] Western Slope Endocrinol, Grand Junction, CO USA. [Klein, Irwin] N Shore Univ Hosp, Thyroid Unit, Manhasset, NY USA. [Laurberg, Peter] Aarhus Univ Hosp, Dept Endocrinol, Aalborg, Denmark. [McDougall, I. Ross] Stanford Univ, Sch Med, Dept Radiol, Div Nucl Med, Stanford, CA 94305 USA. [McDougall, I. Ross] Stanford Univ, Dept Med, Sch Med, Div Endocrinol, Stanford, CA 94305 USA. [Rivkees, Scott A.] Yale Pediat Thyroid Ctr, Dept Pediat, New Haven, CT USA. [Ross, Douglas S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Sosa, Julie Ann] Yale Univ, Sch Med, Div Endocrine Surg, New Haven, CT USA. [Sosa, Julie Ann] Yale Univ, Sch Med, Div Surg Oncol, New Haven, CT USA. RP Bahn, RS (reprint author), Mayo Clin, Div Endocrinol Metab & Nutr, 200 1st St SW, Rochester, MN 55905 USA. EM bahn.rebecca@mayo.edu OI Stan, Marius/0000-0002-1408-8125; Montori, Victor/0000-0003-0595-2898 FU Genzyme FX D.R. is a consultant for Abbott Laboratories and has received research grant support from Genzyme. For all other authors, no competing financial interests exist. NR 358 TC 148 Z9 167 U1 3 U2 32 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 EI 1557-9077 J9 THYROID JI Thyroid PD JUN PY 2011 VL 21 IS 6 BP 593 EP 646 DI 10.1089/thy.2010.0417 PG 54 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 775LM UT WOS:000291461000005 PM 21510801 ER PT J AU Henning, JS Firoz, BF AF Henning, J. S. Firoz, B. F. TI Rituxan is not associated with Stevens Johnson Syndrome SO ANNALS OF ONCOLOGY LA English DT Letter C1 [Henning, J. S.] Brooke Army Med Ctr, Dept Dermatol, San Antonio, TX USA. [Firoz, B. F.] Univ Texas Hlth Sci Ctr, Dept Dermatol, San Antonio, TX USA. RP Henning, JS (reprint author), Brooke Army Med Ctr, Dept Dermatol, San Antonio, TX USA. EM jeffery.henning@us.af.mil NR 3 TC 4 Z9 4 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD JUN PY 2011 VL 22 IS 6 BP 1463 EP U226 DI 10.1093/annonc/mdr254 PG 2 WC Oncology SC Oncology GA 770BA UT WOS:000291060800034 PM 21525404 ER PT J AU Boksiner, J AF Boksiner, Jeffrey TI Obtaining effective metamaterial parameters through modal analysis SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article AB We develop a general method for analyzing the behavior of MTMs using modal decomposition. We replace the inclusions by equivalent lumped circuit elements and use transmission-line theory to solve the propagation problem in the longitudinal direction. This approach calculates physically observable quantities, such as the input impedance, reflection coefficient, dispersion relation, etc., directly without relying on homogenization first. Unlike previous methods, our method can handle complex configurations such as multiple graduated or random inclusion layers within an MTM unit cell. We calculate equivalent constitutive parameters that take into account the entire unit cell and any interactions among the shunt and series elements of the unit cell. We illustrate the utility of our model by evaluating the performance of a MTM composed of unit cells that consist of several layers of SRRs with graduated resonant frequency. C1 USA, CERDEC, S&TCD, Aberdeen Proving Ground, MD USA. RP Boksiner, J (reprint author), USA, CERDEC, S&TCD, Aberdeen Proving Ground, MD USA. NR 10 TC 0 Z9 0 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 EI 1432-0630 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD JUN PY 2011 VL 103 IS 3 BP 555 EP 559 DI 10.1007/s00339-010-6186-y PG 5 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 771MF UT WOS:000291161700009 ER PT J AU Mann, EA Wood, GL Wade, CE AF Mann, Elizabeth A. Wood, Geri L. Wade, Charles E. TI Use of procalcitonin for the detection of sepsis in the critically ill burn patient: A systematic review of the literature SO BURNS LA English DT Review DE Procalcitonin; Sepsis; Intensive care; Burn; Diagnosis ID SERUM PROCALCITONIN; EARLY INDICATOR; EARLY-DIAGNOSIS; METAANALYSIS; INFECTION; TRAUMA; INJURY; ASSOCIATION; PREDICTORS; BACTEREMIA AB The purpose of this systematic review was to assess the evidence for use of routine procalcitonin testing to diagnose the presence of sepsis in the burn patient. The electronic databases MEDLINE, Cochrane, CINAHL, Pro Quest, and SCOPUS were searched for relevant studies using the MeSH terms burn, infection, procalcitonin, and meta-analysis. The focus of the review was the adult burn population, but other relevant studies of critically ill patients were included as data specific to the patient with burns are limited. Studies were compiled in tabular form and critically appraised for quality and level of evidence. Four meta-analyses, one review of the literature, one randomized controlled trial, nine prospective observational, and three retrospective studies were retrieved. Six of these studies were specific to the burn population, with one specific to burned children. Only one meta-analysis, one adult burn and one pediatric burn study reported no benefit of procalcitonin testing to improve diagnosis of sepsis or differentiate sepsis from non-infectious systemic inflammatory response. The collective findings of the included studies demonstrated benefit of incorporating procalcitonin assay into clinical sepsis determination. Evaluation of the burn specific studies is limited by the use of guidelines to define sepsis and inconsistent results from the burn studies. Utility of the procalcitonin assay is limited due to the lack of availability of rapid, inexpensive tests. However, it appears procalcitonin assay is a safe and beneficial addition to the clinical diagnosis of sepsis in the burn intensive care unit. Published by Elsevier Ltd and ISBI. C1 [Mann, Elizabeth A.; Wood, Geri L.] Univ Texas Hlth Sci Ctr, Sch Nursing, Houston, TX USA. [Wood, Geri L.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Mann, Elizabeth A.; Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA. RP Mann, EA (reprint author), 335 Pershing Ave, San Antonio, TX 78209 USA. EM Elizabeth.Mann@us.army.mil NR 37 TC 36 Z9 43 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD JUN PY 2011 VL 37 IS 4 BP 549 EP 558 DI 10.1016/j.burns.2010.04.013 PG 10 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 771RI UT WOS:000291178000001 PM 20537467 ER PT J AU Crum-Cianflone, NF Roediger, M Eberly, LE Ganesan, A Weintrob, A Johnson, E Agan, BK AF Crum-Cianflone, Nancy F. Roediger, Mollie Eberly, Lynn E. Ganesan, Anuradha Weintrob, Amy Johnson, Erica Agan, Brian K. CA Infect Dis Clinical Res Program TI Impact of Weight on Immune Cell Counts among HIV-Infected Persons SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID BODY-MASS INDEX; C-REACTIVE PROTEIN; ACTIVE ANTIRETROVIRAL THERAPY; PERIPHERAL-BLOOD; DISEASE PROGRESSION; OBESITY; OVERWEIGHT; ADULTS; SURVIVAL; RISK AB Prior studies have shown that weight may impact immune cell counts. However, few data exist about the relationship of weight and immune cell counts among HIV-infected patients. We examined documented HIV seroconverters (mean window, 15.7 months) in a prospective U. S. Military HIV Natural History Study (1 January 1986 to 20 January 2010). We estimated the association of the time-updated body mass index (BMI) category with changes in immune cell counts from HIV diagnosis across time (mean follow-up of 5.1 years) using multiply adjusted longitudinal linear mixed-effects models. Of 1,097 HIV seroconverters, 448 (41%) were overweight and 93 (8%) were obese at HIV diagnosis. Immune cell counts at HIV diagnosis did not significantly differ by BMI category. In the longitudinal models for those diagnosed before the advent of the highly active antiretroviral therapy (HAART) era, mean postdiagnosis decreases in the white cell count, total lymphocyte count, CD4 count, CD4 percentage, and CD4/CD8 ratio were less as the BMI category increased (all with P values of <0.05). Among HIV seroconverters diagnosed in the HAART era, obese compared to normal-weight patients had significantly smaller increases in CD4 counts, CD4 percentages, and the CD4/CD8 ratio (all with P values of <0.05). Similar findings were also noted among underweight versus normal-weight patients. In conclusion, although BMI was not associated with immune cell levels at the time of HIV diagnosis, weight appears to affect immune cells counts over the course of infection. In the HAART era, being either underweight or obese was associated with smaller increases in several important immune cell levels, including the CD4/CD8 ratio. C1 [Crum-Cianflone, Nancy F.; Roediger, Mollie; Eberly, Lynn E.; Ganesan, Anuradha; Weintrob, Amy; Johnson, Erica; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92134 USA. [Roediger, Mollie; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Johnson, Erica] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), USN, Med Ctr, Clin Investigat Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-06]; Department of Defense (DoD) through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP-000-06) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 49 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2011 VL 18 IS 6 BP 940 EP 946 DI 10.1128/CVI.00020-11 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 771HH UT WOS:000291147300007 PM 21525303 ER PT J AU Maxwell, GL Hood, BL Day, R Chandran, U Kirchner, D Kolli, VSK Bateman, NW Allard, J Miller, C Sun, M Flint, MS Zahn, C Oliver, J Banerjee, S Litzi, T Parwani, A Sandburg, G Rose, S Becich, MJ Berchuck, A Kohn, E Risinger, JI Conrads, TP AF Maxwell, G. Larry Hood, Brian L. Day, Roger Chandran, Uma Kirchner, David Kolli, V. S. Kumar Bateman, Nicolas W. Allard, Jay Miller, Caela Sun, Mai Flint, Melanie S. Zahn, Chris Oliver, Julie Banerjee, Subhadra Litzi, Tracy Parwani, Anil Sandburg, Glenn Rose, Scott Becich, Michael J. Berchuck, Andrew Kohn, Elise Risinger, John I. Conrads, Thomas P. TI Proteomic analysis of stage I endometrial cancer tissue: Identification of proteins associated with oxidative processes and inflammation SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Endometrial cancer; Laser capture microdissection; Proteomics; Stage I ID GENE-EXPRESSION PROFILES; DIFFERENT HISTOLOGIC TYPES; H2O2-INDUCED CELL-DEATH; HUMAN BREAST-TUMORS; DIFFERENTIAL EXPRESSION; MICROARRAY ANALYSIS; RIBOSOMAL-PROTEINS; PEROXIREDOXIN-I; ANNEXIN A1; CARCINOMA AB Objective. The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. Methods. A differential MS-based proteomic analysis was conducted from discrete epithelial cell populations gathered by laser microdissection from 91 pathologically reviewed stage I endometrial cancer tissue samples (79 endometrioid and 12 serous) and 10 samples of normal endometrium from postmenopausal women. Hierarchical cluster analysis of protein abundance levels derived from a spectral count analysis revealed a number of proteins whose expression levels were common as well as unique to both histologic types. An independent set of endometrial cancer specimens from 394 patients were used to externally validate the differential expression of select proteins. Results. 209 differentially expressed proteins were identified in a comparison of stage I endoimetrial cancers and normal post-menopausal endometrium controls (Q < 0.005). A number of differentially abundant proteins in stage I endometrial cancer were identified and independently validated by western blot and tissue microarray analyses. Multiple proteins identified with elevated abundance in stage I endometrial cancer are functionally associated with inflammation (annexins) and oxidative processes (peroxiredoxins). PRDX1 and ANXA2 were both confirmed as being overexpressed in stage I cancer compared to normal endometrium by independent TMA (Q=0.008 and Q=0.00002 respectively). Conclusions. These data provide the basis for further investigation of previously unrecognized novel pathways involved in early stage endometrial carcinogenesis and provide possible targets for prevention strategies that are inclusive of both endometrioid and serous histologic subtypes. Published by Elsevier Inc. C1 [Maxwell, G. Larry; Allard, Jay; Miller, Caela; Rose, Scott] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. [Maxwell, G. Larry; Allard, Jay; Miller, Caela; Oliver, Julie; Banerjee, Subhadra; Litzi, Tracy; Kohn, Elise; Conrads, Thomas P.] NCI, Canc Res Ctr, Walter Reed Lab Gynecol Dis, Bethesda, MD 20892 USA. [Maxwell, G. Larry; Hood, Brian L.; Miller, Caela; Conrads, Thomas P.] Womens Hlth Integrated Res Ctr Inova Hlth Syst, Fairfax, VA USA. [Day, Roger; Chandran, Uma; Bateman, Nicolas W.; Sun, Mai; Flint, Melanie S.; Parwani, Anil; Becich, Michael J.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Kirchner, David; Kolli, V. S. Kumar] Windber Res Inst, Johnstown, PA USA. [Zahn, Chris] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sandburg, Glenn] Duke Univ, Med Ctr, Armed Forces Inst Pathol, Durham, NC USA. [Berchuck, Andrew] Duke Univ, Med Ctr, Div Gynecol Oncol, Durham, NC USA. [Risinger, John I.] Michigan State Univ, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, 6900 Georgia Ave, Washington, DC 20307 USA. EM george.maxwell@us.army.mil OI Flint, Melanie/0000-0001-5311-3023; parwani, anil/0000-0002-7616-1666 FU Department of Defense Telemedicine and Advanced Technology Center [W81XWH-05-2-0005] FX The opinions expressed in this article represent the private views of the authors and should not be construed as reflecting the official views of the Department of Defense. This study was funded by the Department of Defense Telemedicine and Advanced Technology Center, Award Number W81XWH-05-2-0005. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 45 TC 18 Z9 21 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN 1 PY 2011 VL 121 IS 3 BP 586 EP 594 DI 10.1016/j.ygyno.2011.02.031 PG 9 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 772NN UT WOS:000291240700030 PM 21458040 ER PT J AU Phippen, NT Lowery, WJ Banks, NB Leath, CA AF Phippen, Neil T. Lowery, William J. Banks, Nancy Beaman Leath, Charles A., III TI Multiple synchronous primary ovarian malignancies in a patient with a MLH-1 mutation: Impact on potential fertility preservation SO GYNECOLOGIC ONCOLOGY LA English DT Editorial Material ID CANCER C1 [Phippen, Neil T.; Leath, Charles A., III] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, San Antonio, TX 78234 USA. [Lowery, William J.] Duke Univ, Div Gynecol Oncol, Dept Obstet & Gynecol, Durham, NC USA. [Banks, Nancy Beaman] Brooke Army Med Ctr, Dept Pathol, San Antonio, TX 78234 USA. RP Leath, CA (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM Trey_Leath@yahoo.com OI Leath III, Charles/0000-0002-4034-6845 NR 4 TC 1 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN 1 PY 2011 VL 121 IS 3 BP 637 EP 638 DI 10.1016/j.ygyno.2011.02.011 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 772NN UT WOS:000291240700038 PM 21353691 ER PT J AU Keyser, EA Reed, BG Lowery, WJ Sundborg, MJ Winter, WE Ward, JA Leath, CA AF Keyser, Erin A. Reed, Beverly G. Lowery, William J. Sundborg, Michael J. Winter, William E., III Ward, John A. Leath, Charles A., III TI Hospice enrollment for terminally ill patients with gynecologic malignancies: Impact on outcomes and interventions (vol 118, pg 274, 2010) SO GYNECOLOGIC ONCOLOGY LA English DT Correction C1 [Keyser, Erin A.; Reed, Beverly G.; Lowery, William J.; Leath, Charles A., III] Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. [Sundborg, Michael J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA. [Winter, William E., III] NW Canc Specialists, Portland, OR USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Leath, CA (reprint author), Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. EM Trey_Leath@yahoo.com NR 1 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN 1 PY 2011 VL 121 IS 3 BP 643 EP 643 DI 10.1016/j.ygyno.2011.03.015 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 772NN UT WOS:000291240700045 ER PT J AU Cimpoiasu, E Haugan, TJ Varanasi, CV Levin, GA Barnes, PN AF Cimpoiasu, E. Haugan, T. J. Varanasi, C. V. Levin, G. A. Barnes, P. N. TI Effect of Oxygen Depletion on the Pinning Properties of YBa2Cu3Ox Films With Nanoinclusions SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article DE Nanoparticles; pinning; superconductor; vortex dynamics ID THIN-FILMS; SUPERCONDUCTOR; NANOPARTICLES; DISPERSIONS AB Applications of YBa2Cu3Ox (YBCO) coated conductors require strong vortex pinning to ensure a non-dissipative state over a large range of temperatures and magnetic field values. Incorporations of nanoparticles and nanorods have generally resulted in a substantial increase of pinning, but the actual mechanism producing this increase is not fully understood. This report addresses the origin of the enhanced pinning through comparative resistive measurements in the mixed state of thin films of YBCO, YBCO doped with Y2O3 nanoparticles, and YBCO doped with BaSnO3 nanorods. In order to study the effect of oxygen, all three kinds of samples have been annealed in air at 420 degrees C. We have extracted and compared the resistive irreversibility lines before and after annealing. Our results indicate that while the nanoinclusions in the fully-oxygenated samples improve the pinning strength over that in the pure YBCO sample, the pinning enhancement essentially vanishes upon oxygen depletion. This is true for both pinning structures, nanorods and nanoparticles. C1 [Cimpoiasu, E.] USN Acad, Dept Phys, Annapolis, MD 21412 USA. [Haugan, T. J.; Levin, G. A.; Barnes, P. N.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Varanasi, C. V.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Cimpoiasu, E (reprint author), USN Acad, Dept Phys, Annapolis, MD 21412 USA. EM cimpoias@usna.edu FU AFOSR; AFRL Propulsion Directorate at AFRL; NARC at USNA FX Manuscript received August 02, 2010; accepted October 18, 2010. Date of publication November 18, 2010; date of current version May 27, 2011. This work was partially supported by AFOSR and AFRL Propulsion Directorate at AFRL and NARC at USNA. NR 18 TC 0 Z9 0 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD JUN PY 2011 VL 21 IS 3 BP 3218 EP 3221 DI 10.1109/TASC.2010.2090120 PN 3 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 770DW UT WOS:000291068200174 ER PT J AU Kees, CE Akkerman, I Farthing, MW Bazilevs, Y AF Kees, C. E. Akkerman, I. Farthing, M. W. Bazilevs, Y. TI A conservative level set method suitable for variable-order approximations and unstructured meshes SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Free-surface flow; Level set; Mass conservation; Finite elements; Fluids; Residual-based variational multiscale method ID FINITE-ELEMENT-METHOD; OF-FLUID METHOD; 2-PHASE INCOMPRESSIBLE FLOWS; 2ND-ORDER ELLIPTIC PROBLEMS; INVISCID SUPERSONIC FLOWS; NAVIER-STOKES EQUATIONS; FREE-SURFACE FLOWS; SUPG FORMULATION; GALERKIN METHOD; UNSTEADY FLOWS AB This paper presents a formulation for free-surface computations capable of handling complex phenomena, such as wave breaking, without excessive mass loss or smearing of the interface. The formulation is suitable for discretizations using finite elements of any topology and order, or other approaches such as isogeometric and finite volume methods. Furthermore, the approach builds on standard level set tools and can therefore be used to augment existing implementations of level set methods with discrete conservation properties. Implementations of the method are tested on several difficult two- and three-dimensional problems, including two incompressible air/water flow problems with available experimental results. Linear and quadratic approximations on unstructured tetrahedral and trilinear approximations on hexahedral meshes were tested. Global conservation and agreement with experiments as well as computations by other researchers are obtained. Published by Elsevier Inc. C1 [Kees, C. E.; Akkerman, I.; Farthing, M. W.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Akkerman, I.; Bazilevs, Y.] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92123 USA. RP Kees, CE (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM christopher.e.kees@usace.army.mil; idoakkerman@gmail.com; matthew.w.farthing@usace.army.mil; yuri@ucsd.edu RI Akkerman, Ido/H-9957-2012 FU Teragrid [MCAD7S032]; J. Tinsley Oden faculty; US Army Corps of Engineers; Army Research Office [W911NF-10-1-0247] FX The authors thank Prof. C.N. Dawson and Prof. S. Prudhomme for their suggestions on discretizations of the conservation correction, Prof. A.L.G.A. Coutinho for his valuable input on the second test problem, and Prof. T.E. Tezduyar and Dr. K. Takizawa for fruitful discussions regarding free-surface flows and fluid object interaction. We also wish to thank the Texas Advanced Computing Center (TACC) at the University of Texas at Austin for providing HPC resources that have contributed to the research results reported within this paper. Support from Teragrid Grant No. MCAD7S032, the J. Tinsley Oden faculty fellowship program, the Navigation Systems and Military Engineering 6.1 research programs of the US Army Corps of Engineers are gratefully acknowledged. Y. Bazilevs was supported by the Army Research Office Award W911NF-10-1-0247. Permission was granted by the Chief of Engineers to publish this information. NR 72 TC 37 Z9 38 U1 3 U2 18 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD JUN 1 PY 2011 VL 230 IS 12 BP 4536 EP 4558 DI 10.1016/j.jcp.2011.02.030 PG 23 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 770YW UT WOS:000291125400010 ER PT J AU Seely, AJE Kauffman, SA Bates, JHT Macklem, PT Suki, B Marshall, JC Batchinsky, AI Perez-Velazquez, JL Seiver, A McGregor, C Maksym, G Eng, MVKP Similowski, T Buchman, TG Letellier, C Filoche, M Frasch, MG Straus, C Glass, L Godin, PJ Morris, JA Sow, D Nenadovic, V Arnold, RC Norris, P Moorman, JR AF Seely, Andrew J. E. Kauffman, Stuart A. Bates, Jason H. T. Macklem, Peter T. Suki, Bela Marshall, John C. Batchinsky, Andriy I. Perez-Velazquez, Jose Luis Seiver, Adam McGregor, Carolyn Maksym, Geoffrey Eng, Markad V. Kamath P. Similowski, Thomas Buchman, Timothy G. Letellier, Christophe Filoche, Marcel Frasch, Martin G. Straus, Christian Glass, Leon Godin, Paul J. Morris, John A. Sow, Daby Nenadovic, Vera Arnold, Ryan C. Norris, Patrick Moorman, J. Randall TI Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside SO JOURNAL OF CRITICAL CARE LA English DT Editorial Material C1 [Seely, Andrew J. E.] Univ Ottawa, Ottawa Hosp, Res Inst, Div Thorac Surg, Ottawa, ON K1N 6N5, Canada. [Seely, Andrew J. E.] Univ Ottawa, Ottawa Hosp, Res Inst, Div Crit Care Med, Ottawa, ON K1N 6N5, Canada. [Kauffman, Stuart A.] Univ Vermont, Coll Med, Burlington, VT 05405 USA. [Bates, Jason H. T.] Univ Vermont, Sch Engn, Dept Med, Burlington, VT 05405 USA. [Macklem, Peter T.] McGill Univ, Dept Med, Quebec City, PQ, Canada. [Suki, Bela] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA. [Marshall, John C.] St Michaels Hosp, Toronto, ON, Canada. [Marshall, John C.] Univ Toronto, Sch Med, Dept Surg, Toronto, ON M5S 1A1, Canada. [Marshall, John C.] Univ Toronto, Sch Med, Dept Crit Care, Toronto, ON M5S 1A1, Canada. [Batchinsky, Andriy I.] USA, Inst Surg Res, Ft Sam Houston, TX USA. [Perez-Velazquez, Jose Luis] Toronto Hosp Sick Kids, Dept Paediat, Toronto, ON, Canada. [Perez-Velazquez, Jose Luis] Toronto Hosp Sick Kids, Div Crit Care Med, Toronto, ON, Canada. [Seiver, Adam] Philips Healthcare, Hosp Resp Care, Irvine, CA USA. [McGregor, Carolyn] Univ Ontario, Inst Technol, Fac Hlth Sci, Fac Business & Informat Technol, London, ON, Canada. [Maksym, Geoffrey] Dalhousie Univ, Dept Phys, Sch Biomed Engn, Halifax, NS B3H 3J5, Canada. [Eng, Markad V. Kamath P.] McMaster Univ, Sch Biomed Engn, Dept Med, Hamilton, ON L8S 4L8, Canada. [Similowski, Thomas; Straus, Christian] Univ Paris 06, Pitie Salpetriere Hosp, Paris, France. [Letellier, Christophe] Univ Rouen, Dept Biomed Engn, Rouen, France. [Filoche, Marcel] Ecole Polytech, CNRS, F-91128 Palaiseau, France. [Frasch, Martin G.] Univ Montreal, Dept Obstet & Gynecol, CHU Ste Justine Res Ctr, Quebec City, PQ, Canada. [Glass, Leon] McGill Univ, Dept Physiol, Quebec City, PQ, Canada. [Morris, John A.; Norris, Patrick] Vanderbilt Univ Sch Med, Div Trauma & Surg Crit Care, Nashville, TN USA. [Sow, Daby] IBM TJ Watson Res Ctr, Hawthorne, NY USA. [Nenadovic, Vera] Toronto Hosp Sick Kids, Crit Care Unit, Toronto, ON, Canada. [Arnold, Ryan C.] Cooper Univ Hosp, Dept Emergency Med, Camden, NJ USA. [Moorman, J. Randall] Univ Virginia, Dept Internal Med & Biomed Engn, Div Cardiovasc, Charlottesville, VA 22903 USA. RP Seely, AJE (reprint author), Univ Ottawa, Ottawa Hosp, Res Inst, Div Thorac Surg, Ottawa, ON K1N 6N5, Canada. EM aseely@ottawahospital.on.ca; stukauffman@gmail.com; jason.h.bates@uvm.edu; bsuki@bu.edu; marshallj@smh.toronto.on.ca; andriy.batchinsky@amedd.army.mil; jose-luis.perez-velazquez@sickkids.ca; adam.seiver@philips.com; carolyn.mcgregor@uoit.ca; gmaksym@dal.ca; kamathm@univmail.cis.mcmaster.ca; thomas.similowski@psl.aphp.fr; tbuchma@emory.edu; christophe.letellier@coria.fr; marcel.filoche@gmail.com; mg.frasch@umontreal.ca; christian.straus@psl.aphp.fr; glass@cnd.mcgill.ca; pgodin1@gmail.com; john.morris@vanderbilt.edu; sowdaby@us.ibm.com; vera.nenadovic@sickkids.ca; arnold-ryan@cooperhealth.edu; patrick.norris@vanderbilt.edu; rm3h@virginia.edu RI Letellier, Christophe/E-2245-2012; Frasch, Martin/B-3539-2014; OI Letellier, Christophe/0000-0003-3603-394X; Frasch, Martin/0000-0003-3159-6321; Buchman, Timothy/0000-0001-7350-5921; FILOCHE, Marcel/0000-0001-8637-3016 NR 0 TC 6 Z9 6 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD JUN PY 2011 VL 26 IS 3 BP 325 EP 327 DI 10.1016/j.jcrc.2011.04.002 PG 3 WC Critical Care Medicine SC General & Internal Medicine GA 774MH UT WOS:000291390200019 PM 21616298 ER PT J AU Bermudez-Aguirre, D Fernandez, S Esquivel, H Dunne, PC Barbosa-Canovas, GV AF Bermudez-Aguirre, Daniela Fernandez, Sulmer Esquivel, Heracleo Dunne, Patrick C. Barbosa-Canovas, Gustavo V. TI Milk Processed by Pulsed Electric Fields: Evaluation of Microbial Quality, Physicochemical Characteristics, and Selected Nutrients at Different Storage Conditions SO JOURNAL OF FOOD SCIENCE LA English DT Article DE milk; nonthermal technology; pulsed electric fields; storage life ID SKIM MILK; SHELF-LIFE; STAPHYLOCOCCUS-AUREUS; THERMO-SONICATION; LISTERIA-INNOCUA; HEAT-TREATMENTS; METAL RELEASE; WHOLE MILK; INACTIVATION; PEF AB Pulsed electric fields (PEF) technology was used to pasteurize raw milk under selected treatments. Processing conditions were: temperature 20, 30, and 40 degrees C, electric field 30.76 to 53.84 kV/cm, and pulse numbers 12, 24, and 30 for skim milk (SM), and 12, 21, and 30 for whole milk (WM) (2 mu s pulse width, monopolar). Physicochemical parameters (pH, electrical conductivity, density, color, solids nonfat [SNF]) and composition (protein and fat content) were measured after processing. Shelf life of SM and WM was assessed after processing at 46.15 kV/cm, combined with temperature (20 to 60 degrees C) and 30 pulses. Mesophilic and psychrophilic loads and pH were evaluated during storage at 4 and 21 degrees C. Results showed minor variations in physicochemical properties after processing. There was an interesting trend in SM in SNF, which decreased as treatment became stronger; similar behavior was observed for fat and protein, showing a 0.18% and 0.17% decrease, respectively, under the strongest conditions. Protein and fat content decreased in WM samples treated at 40 degrees C, showing a decrease in protein (0.11%), and an even higher decrease in fat content. During storage, PEF-treated milk samples showed higher stability at 4 degrees C with minor variations in pH; after 33 d, pH was higher than 6. However samples at 21 degrees C showed faster spoilage and pH dropped to 4 after 5 d. Growth of mesophilic bacteria was delayed in both milks after PEF processing, showing a 6- and 7-log cycles for SM and WM, respectively, after day 25 (4 degrees C); however, psychrophilic bacteria grew faster in both cases. Practical Application Pulsed electric fields (PEF) technology in the pasteurization of liquid food products has shown positive results. Processing times can be reduced considerably, which in turn reduces the loss of nutrients and offers important savings in energy. PEF has been used successfully to pasteurize some liquid foods, but it is still not used commercially in milk pasteurization, although several trials have shown the positive effects of PEF milk pasteurization, which could allow for its future use at the industrial level. C1 [Bermudez-Aguirre, Daniela; Fernandez, Sulmer; Esquivel, Heracleo; Barbosa-Canovas, Gustavo V.] Washington State Univ, Ctr Nonthermal Proc Food, Pullman, WA 99164 USA. [Dunne, Patrick C.] USA, Natick Soldier Ctr, Natick, MA 01760 USA. RP Barbosa-Canovas, GV (reprint author), Washington State Univ, Ctr Nonthermal Proc Food, Pullman, WA 99164 USA. EM barbosa@wsu.edu NR 42 TC 9 Z9 10 U1 0 U2 36 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD JUN-JUL PY 2011 VL 76 IS 5 BP S289 EP S299 DI 10.1111/j.1750-3841.2011.02171.x PG 11 WC Food Science & Technology SC Food Science & Technology GA 772JV UT WOS:000291231100013 PM 22417443 ER PT J AU Wink, DA Hines, HB Cheng, RYS Switzer, CH Flores-Santana, W Vitek, MP Ridnour, LA Colton, CA AF Wink, David A. Hines, Harry B. Cheng, Robert Y. S. Switzer, Christopher H. Flores-Santana, Wilmarie Vitek, Michael P. Ridnour, Lisa A. Colton, Carol A. TI Nitric oxide and redox mechanisms in the immune response SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Review DE oxidative nitrosative stress; signaling cascade ID FACTOR-KAPPA-B; HUMAN-IMMUNODEFICIENCY-VIRUS; CELL-MEDIATED IMMUNOSUPPRESSION; CYTOSOLIC PHOSPHOLIPASE A(2); SYNTHASE TYPE-2 EXPRESSION; RAT ALVEOLAR MACROPHAGES; NECROSIS-FACTOR-ALPHA; HUMAN MONOCYTIC CELLS; GROWTH-FACTOR BETA-1; REGULATORY T-CELLS AB The role of redox molecules, such as NO and ROS, as key mediators of immunity has recently garnered renewed interest and appreciation. To regulate immune responses, these species trigger the eradication of pathogens on the one hand and modulate immunosuppression during tissue-restoration and wound-healing processes on the other. In the acidic environment of the phagosome, a variety of RNS and ROS is produced, thereby providing a cauldron of redox chemistry, which is the first line in fighting infection. Interestingly, fluctuations in the levels of these same reactive intermediates orchestrate other phases of the immune response. NO activates specific signal transduction pathways in tumor cells, endothelial cells, and monocytes in a concentration-dependent manner. As ROS can react directly with NO-forming RNS, NO bioavailability and therefore, NO response(s) are changed. The NO/ROS balance is also important during Th1 to Th2 transition. In this review, we discuss the chemistry of NO and ROS in the context of antipathogen activity and immune regulation and also discuss similarities and differences between murine and human production of these intermediates. J. Leukoc. Biol. 89: 873-891; 2011. C1 [Wink, David A.; Cheng, Robert Y. S.; Switzer, Christopher H.; Flores-Santana, Wilmarie; Ridnour, Lisa A.] NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA. [Hines, Harry B.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD USA. [Vitek, Michael P.; Colton, Carol A.] Duke Univ, Med Ctr, Div Neurol, Durham, NC 27710 USA. RP Wink, DA (reprint author), NCI, Radiat Biol Branch, NIH, Bldg 10,Room B3-B35, Bethesda, MD 20892 USA. EM wink@mail.nih.gov; glia01@aol.com RI Switzer, Christopher/D-9203-2013; OI Cheng, Robert/0000-0003-0287-6439 FU NIA NIH HHS [R01 AG031845, R01 AG031124] NR 251 TC 187 Z9 192 U1 5 U2 42 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUN PY 2011 VL 89 IS 6 BP 873 EP 891 DI 10.1189/jlb.1010550 PG 19 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 770SI UT WOS:000291108400008 PM 21233414 ER PT J AU Sun, YM Li, YZ AF Sun, Yongmin Li, Yuanzhang TI Effects of Family Structure Type and Stability on Children's Academic Performance Trajectories SO JOURNAL OF MARRIAGE AND FAMILY LA English DT Article DE academic performance; child development; family instability; family structure; growth-curve models; hierarchical linear models ID PARENTS MARITAL DISRUPTION; HIGH-SCHOOL; ADJUSTMENT PROBLEMS; PREMARITAL BIRTH; TRANSITIONS; ADOLESCENTS; ACHIEVEMENT; INSTABILITY; RISK; CONSEQUENCES AB Using five waves of panel data from 8,008 children in the ECLS-K, the current study compared children's academic performance growth curves from kindergarten through fifth grade among three types of nondisrupted and three types of disrupted families. The analyses found that children in nondisrupted two-biological-parent and nondisrupted stepparent households consistently made greater progress in their math and reading performances over time than their peers in nondisrupted single-parent, disrupted two-biological-parent, and disrupted alternative families with multiple transitions. These trajectory differences were either partially or completely accounted for by family resources in the kindergarten year (Time 1). Overall, our findings provided strong support for the resource-deprivation perspective and partial support for the instability-stress perspective. C1 [Sun, Yongmin] Ohio State Univ, Dept Sociol, Mansfield, OH 44906 USA. [Li, Yuanzhang] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Sun, YM (reprint author), Ohio State Univ, Dept Sociol, 1680 Univ Dr, Mansfield, OH 44906 USA. EM sun.84@osu.edu OI Li, Yuanzhang/0000-0001-8872-4430 NR 46 TC 14 Z9 14 U1 1 U2 37 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-2445 J9 J MARRIAGE FAM JI J. Marriage Fam. PD JUN PY 2011 VL 73 IS 3 BP 541 EP 556 DI 10.1111/j.1741-3737.2011.00825.x PG 16 WC Family Studies; Sociology SC Family Studies; Sociology GA 766GL UT WOS:000290768900002 ER PT J AU Koppenhaver, SL Fritz, JM Hebert, JJ Kawchuk, GN Childs, JD Parent, EC Gill, NW Teyhen, DS AF Koppenhaver, Shane L. Fritz, Julie M. Hebert, Jeffrey J. Kawchuk, Greg N. Childs, John D. Parent, Eric C. Gill, Norman W. Teyhen, Deydre S. TI Association Between Changes in Abdominal and Lumbar Multifidus Muscle Thickness and Clinical Improvement After Spinal Manipulation SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE low back pain; muscle contraction; transversus abdominis; ultrasound ID LOW-BACK-PAIN; LEG RAISE TEST; TRANSVERSUS ABDOMINIS; STRENGTH PERFORMANCE; PARASPINAL MUSCLES; PREDICTION RULE; DISC HERNIATION; TRUNK MUSCLES; CONTRACTION; RELIABILITY AB STUDY DESIGN: Prospective case series. OBJECTIVE: To examine the relation between improved disability and changes in abdominal and lumbar multifidus (LM) thickness using ultrasound imaging following spinal manipulative therapy (SMT) in patients with low back pain (LBP). BACKGROUND: Although there is a growing body of literature demonstrating physiologic effects following the application of SMT, few studies have attempted to correlate these changes with clinically relevant outcomes. METHODS: Eighty-one participants with LBP underwent 2 thrust SMT treatments and 3 assessment sessions within 1 week. Transversus abdominis (TrA), internal oblique (10), and LM muscle thickness was assessed during each session, using ultrasound imaging of the muscles at rest and during submaximal contractions. The Modified Oswestry Disability Index was used to quantify participants' improvement in LBP-related disability. Stepwise hierarchical multiple linear regression and repeated-measures analysis of variance were performed to examine the multivariate relationship between change in muscle thickness and clinical improvement over time. RESULTS: After controlling for the effects of age, sex, and body mass index, change in contracted LM muscle thickness was predictive of improved disability at 1 week (P = .02). As expected, larger increases in contracted LM muscle thickness at 1 week were associated with larger improvements in LBP-related disability. Contrary to our hypothesis, significant decreases in both contracted TrA and 10 muscle thickness were observed immediately following SMT; but these changes were transient and unrelated to whether participants experienced clinical improvements. CONCLUSION: These findings provide evidence that clinical improvement following SMT is associated with increased thickening of the LM muscle during a submaximal task. LEVEL OF EVIDENCE: Prognosis, level 4. J Orthop Sports Phys Ther 2011:41(6):389-399, Epub 6 April 2011. doi:10.2519/jospt.2011.3632 C1 [Koppenhaver, Shane L.; Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX 78209 USA. [Fritz, Julie M.] Univ Utah, Coll Hlth, Salt Lake City, UT USA. [Hebert, Jeffrey J.] Murdoch Univ, Sch Chiropract & Sports Sci, Perth, WA, Australia. [Kawchuk, Greg N.; Parent, Eric C.] Univ Alberta, Dept Phys Therapy, Edmonton, AB, Canada. [Parent, Eric C.] Glenrose Rehabil Hosp, Edmonton, AB, Canada. RP Koppenhaver, SL (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, 414 Robinhood Pl, San Antonio, TX 78209 USA. EM shanekoppenhaver@mac.com RI Hebert, Jeffrey/C-4614-2008 OI Hebert, Jeffrey/0000-0002-6959-325X FU National Institutes of Health, National Center for Complementary and Alternative Medicine [R21 AT004221] FX This study was supported by the National Institutes of Health, National Center for Complementary and Alternative Medicine (R21 AT004221). This study was approved by The Institutional Review Boards of the University of Utah and Brooke Army Medical Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Departments of the Army or Defense. NR 62 TC 20 Z9 21 U1 1 U2 5 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2011 VL 41 IS 6 BP 389 EP 399 DI 10.2519/jospt.2011.3632 PG 11 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 772NY UT WOS:000291241800004 PM 21471653 ER PT J AU Kiang, JE Olsen, JR Waskom, RM AF Kiang, Julie E. Olsen, J. Rolf Waskom, Reagan M. TI Introduction to the Featured Collection on "Nonstationarity, Hydrologic Frequency Analysis, and Water Management" SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Editorial Material ID UNITED-STATES; STREAMFLOW AB Kiang, Julie E., J. Rolf Olsen, and Reagan M. Waskom, 2011. Introduction to the Featured Collection on "Nonstationarity, Hydrologic Frequency Analysis, and Water Management." Journal of the American Water Resources Association (JAWRA) 47(3):433-435. DOI: 10.1111/j.1752-1688.2011.00551.x. C1 [Kiang, Julie E.] US Geol Survey, Natl Ctr 415, Reston, VA 20192 USA. [Olsen, J. Rolf] USA, Inst Water Resources, Corp Engineers, Alexandria, VA USA. [Waskom, Reagan M.] Colorado State Univ, Colorado Water Inst, Ft Collins, CO 80523 USA. RP Kiang, JE (reprint author), US Geol Survey, Natl Ctr 415, Reston, VA 20192 USA. EM jkiang@usgs.gov NR 5 TC 6 Z9 6 U1 1 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2011 VL 47 IS 3 BP 433 EP 435 DI 10.1111/j.1752-1688.2011.00551.x PG 3 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 772HL UT WOS:000291224900001 ER PT J AU Kim, HC Klein, TA Kang, HJ Gu, SH Moon, SS Baek, LJ Chong, ST O'Guinn, ML Lee, JS Turell, MJ Song, JW AF Kim, Heung Chul Klein, Terry A. Kang, Hae Ji Gu, Se Hun Moon, Sung Sil Baek, Luck Ju Chong, Sung Tae O'Guinn, Monica L. Lee, John S. Turell, Michael J. Song, Jin-Won TI Ecological surveillance of small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005 SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Rodents; insectivores; ecology; Apodemus; Rattus; Micromys; Microtus; Myodes; Tscherskia; Crocidura; Korea ID BORNE ENCEPHALITIS-VIRUS; SIN-NOMBRE-VIRUS; FIRING POINTS 10; SCRUB TYPHUS; HEMORRHAGIC-FEVER; SEROLOGICAL SURVEILLANCE; RODENT POPULATIONS; APODEMUS-AGRARIUS; ETIOLOGIC AGENT; MURINE TYPHUS AB A seasonal rodent-borne disease surveillance program was established at Dagmar North Training Area located near the demilitarized zone, Republic of Korea, from 2001 through 2005. Selected habitats surveyed included earthen banks separating rice paddies, fighting positions along a 5 m rock-faced earthen berm, and extensive tall grasses with various degrees of herbaceous and scrub vegetation associated with dirt roads, rice paddies, ditches, ponds, or the Imjin River. Of the nine species of small mammals captured, the striped field mouse (Apodemus agrarius), the primary reservoir for Hantaan virus, was the most frequently collected, representing 92.5% of the 1,848 small mammals captured. Males were captured similarly to females during the spring and summer seasons but were captured less frequently during the fall and winter seasons. Gravid rates were highest in the fall (25.5-57.3%) with the lowest rates during the summer (0.0-2.2%). Capture rates were the lowest along earthen banks separating rice paddies (5.5%) and highest in unmanaged tall grasses and crawling vegetation (15.3-43.5%). An increased knowledge of ecological factors that impact the abundance and distribution of small mammals and the associated ectoparasites and pathogens they harbor is critical for developing accurate disease risk assessments and mitigation strategies for preventing vector-and rodent-borne diseases among soldiers training in field environments. Journal of Vector Ecology 36 (1): 42-54. 2011. C1 [Kang, Hae Ji; Gu, Se Hun; Moon, Sung Sil; Baek, Luck Ju; Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis & Bank Pathogen Viruses, Seoul 136705, South Korea. [O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kim, Heung Chul; Chong, Sung Tae] 65th Med Brigade, 168th Multifunct Med Battal, 5th Med Detachment, Unit 15247, APO, AP 96205 USA. [Klein, Terry A.] 65th Med Brigade, USAMEDDAC Korea, Force Hlth Protect, Unit 15281, APO, AP 96205 USA. RP Song, JW (reprint author), Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis & Bank Pathogen Viruses, 126-1,5Ka Anam Dong, Seoul 136705, South Korea. RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center (AFHSC); Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD; National Center for Medical Intelligence, Fort Detrick, MD FX We are grateful for the assistance of Wan-Young Kim, Edwin Huertas, and Kerry McKinley, Force Health Protection and Preventive Medicine, 65th Medical Brigade, for their support in coordinating personnel for conducting rodent surveillance and Ms. Suk-Hee Yi for conducting data analysis and maps. We also thank the commanders and many soldiers of the Preventive Medicine Detachments, 168th Multifunctional Medical Battalion, for their support in conducting rodent surveillance throughout the five-year surveillance program. We especially thank Si Jung Ha, So Hee Shim, and other graduate students and staff of Korea University for their support in handling and gathering of small mammal bionomics in the laboratory. We are grateful for the support and encouragement that the Commanders, 18th MEDCOM, MG Phillip Volpe, COL Brian Allgood (deceased), and COL James Jolissaint and Preventive Medicine Officer, Force Health Protection, 18th MEDCOM, Hee-Choon (Sam) Lee provided throughout this study. We especially thank Dr. Joel Gaydos, Armed Forces Health Surveillance Center, for his support and encouragement throughout this study. Funding for portions of this work was provided by the Armed Forces Health Surveillance Center (AFHSC), Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD, and the National Center for Medical Intelligence, Fort Detrick, MD. NR 59 TC 6 Z9 6 U1 0 U2 8 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2011 VL 36 IS 1 BP 42 EP 54 PG 13 WC Entomology SC Entomology GA 772II UT WOS:000291227200006 PM 21635640 ER PT J AU Kim, HC Rueda, LM Wilkerson, RC Foley, DH Sames, WJ Chong, ST Nunn, PV Klein, TA AF Kim, Heung-Chul Rueda, Leopoldo M. Wilkerson, Richard C. Foley, Desmond H. Sames, William J. Chong, Sung-Tae Nunn, Peter V. Klein, Terry A. TI Distribution and larval habitats of Anopheles species in northern Gyeonggi Province, Republic of Korea SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Distribution; habitats; Anopheles; Munsan; Gyeonggi Province; Republic of Korea (ROK) ID PLASMODIUM-VIVAX; US FORCES; CULICIDAE; DIPTERA; MALARIA; MOSQUITOS; VECTORS AB A total of 180 larval collection sites (e. g., rice paddies, marshes, ground pools, ponds, stream margins, and irrigation and drainage ditches) was surveyed within a 2 km radius from Warrior Base training area, 5 km south of Panmunjeom (Joint Security Area, demilitarized zone), Gyeonggi Province, Republic of Korea (ROK), from May through October, 2007 to characterize larval habitat distributions of members of the Anopheles Hyrcanus Group (An. sinensis, An. lesteri, An. pullus, An. belenrae, An. kleini, and An. sineroides). A total of 5,859 anopheline larvae was collected from 84.4% of the sites surveyed, of which 4,071 were identified to species by polymerase chain reaction (PCR) using the ribosomal DNA internal transcribed spacer 2 (rDNA ITS2). Anopheles sinensis (52.6%) was the most frequently collected, followed by An. kleini (29.4%), An. sineroides (9.8%), An. pullus (6.7%), An. belenrae (1.1%), and An. lesteri (0.5%). Anopheles pullus and An. kleini were collected in greater proportions in May and from May - July, respectively. Few An. sinensis were collected from May - June, but it was the predominant species collected by August, and accounted for >80% of all larvae from September - October. Anopheles kleini was found in all habitats sampled; however, it was collected most frequently in young growth rice paddies, while An. sinensis was collected more frequently in mature and post-harvest paddies. Anopheles pullus was associated with pre-cultivated rice paddies, including water-filled tire ruts left from the previous fall's harvest. Journal of Vector Ecology 36 (1): 124-134. 2011. C1 [Rueda, Leopoldo M.; Wilkerson, Richard C.; Foley, Desmond H.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Sames, William J.] Walter Reed Army Med Ctr, AFPMB, Washington, DC 20307 USA. [Klein, Terry A.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. [Kim, Heung-Chul; Chong, Sung-Tae; Nunn, Peter V.] 65th Med Brigade, 168th Multifunct Med Battal, 5th Med Detachment, Unit 15247, APO, AP 96205 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 FU Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD; Armed Forces Medical Intelligence Center (AFMIC), Fort Detrick, MD; National Center for Medical Intelligence, Fort Detrick, MD FX We thank the Commander, 65th Medical Brigade and Chief, Force Health Protection and Preventive Medicine, 65thMedical Brigade for their dedicated support. Special thanks go to Ms. Suk-Hee Yi, Force Health Protection and Preventive Medicine, 65th Medical Brigade, for providing geographical information system (GIS) maps of collection sites, and B. P. Rueda for reviewing the manuscript. Funding for this work was provided by the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD, and the Armed Forces Medical Intelligence Center (AFMIC), Fort Detrick, MD and the National Center for Medical Intelligence, Fort Detrick, MD. NR 24 TC 9 Z9 10 U1 2 U2 4 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2011 VL 36 IS 1 BP 124 EP 134 PG 11 WC Entomology SC Entomology GA 772II UT WOS:000291227200016 PM 21635650 ER PT J AU Marion, DW AF Marion, Donald W. TI Decompressive craniectomy in diffuse traumatic brain injury SO LANCET NEUROLOGY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Marion, DW (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. EM donald.marion@us.army.mil NR 8 TC 10 Z9 11 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1474-4422 J9 LANCET NEUROL JI Lancet Neurol. PD JUN PY 2011 VL 10 IS 6 BP 497 EP 498 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 774HK UT WOS:000291376100005 PM 21601156 ER PT J AU Sablon, KA Little, JW Mitin, V Sergeev, A Vagidov, N Reinhardt, K AF Sablon, Kimberly A. Little, John W. Mitin, Vladimir Sergeev, Andrei Vagidov, Nizami Reinhardt, Kitt TI Strong Enhancement of Solar Cell Efficiency Due to Quantum Dots with Built-In Charge SO NANO LETTERS LA English DT Article DE Solar cell; quantum dots; doping; infrared radiation; built-in charge ID ELECTRON-CAPTURE; RELAXATION AB We report a 50% increase in the power conversion efficiency of InAs/GaAs quantum dot solar cells due to n-doping of the interdot space. The n-doped device was compared with GaAs reference cell, undoped, and p-doped devices. We found that the quantum dots with built-in charge (Q-BIC) enhance electron intersubband quantum dot transitions, suppress fast electron capture processes, and preclude deterioration of the open circuit voltage in the n-doped structures. These factors lead to enhanced harvesting and efficient conversion of IR energy in the Q-BIC solar cells. C1 [Mitin, Vladimir; Sergeev, Andrei; Vagidov, Nizami] SUNY Buffalo, Buffalo, NY 14260 USA. [Sablon, Kimberly A.; Little, John W.] USA, Res Lab, Adelphi, MD 20783 USA. [Reinhardt, Kitt] AFOSR NE, Arlington, VA 22203 USA. RP Sergeev, A (reprint author), SUNY Buffalo, Buffalo, NY 14260 USA. EM asergeev@buffalo.edu FU Power and Energy Division; NSF FX The authors thank Kimberley Olver for sample processing, Salamo's group at University of Arkansas for assisting with PL measurements, Fred Towner of Maxion Technologies, Inc. for MBE growth, and Peter Vogl and Stefan Birner from the Walter Schottky Institute, Technische Universitat Munchen for providing us with nextnano3 software. This work was partially supported by ARL Extreme Energy Grant from the Power and Energy Division. The work of A.S. was also partially supported by DMR of NSF. NR 28 TC 133 Z9 136 U1 3 U2 50 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD JUN PY 2011 VL 11 IS 6 BP 2311 EP 2317 DI 10.1021/nl200543v PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 773QJ UT WOS:000291322600020 PM 21545165 ER PT J AU Pasiakos, SM Caruso, CM Kellogg, MD Kramer, FM Lieberman, HR AF Pasiakos, Stefan M. Caruso, Christina M. Kellogg, Mark D. Kramer, F. Matthew Lieberman, Harris R. TI Appetite and Endocrine Regulators of Energy Balance After 2 Days of Energy Restriction: Insulin, Leptin, Ghrelin, and DHEA-S SO OBESITY LA English DT Article ID SERUM DEHYDROEPIANDROSTERONE-SULFATE; OBESE ZUCKER RATS; FOOD-INTAKE; BODY-WEIGHT; HYPOTHALAMIC NEUROTRANSMITTERS; METABOLIC PARAMETERS; CALORIC RESTRICTION; GENE-EXPRESSION; FASTING LEPTIN; PLASMA LEPTIN AB Using a double-blind, placebo-controlled crossover design, the effects of 48 h near complete energy restriction on endocrine regulators of appetite and satiety were assessed. Twelve men and one woman participated in this controlled, 2-day diet intervention study. One experimental trial was completed in a calorie deprived state (CAL-DEP; <10% of estimated energy requirements) and others in a fed condition (carbohydrate only and carbohydrate and fat; data were pooled and compared to CAL-DEP). Test meals containing prescribed energy intake and indistinguishable in sensory characteristics were provided during each trial. Glucose, insulin, leptin, ghrelin, cortisol, dehydroepiandrosterone-sulfate (DHEA-S), and satiety were repeatedly assessed. Mean glucose, insulin, and leptin concentrations were lower (P < 0.0001) for CAL-DEP compared to the fully fed (FED) state. Ghrelin and DHEA-S were higher (P < 0.0001) for CAL-DEP relative to FED. Cortisol levels declined each day regardless of diet (P < 0.0001) but were 32% higher (P < 0.01) at the conclusion of the session for CAL-DEP compared to FED. Satiety was 25% lower (P < 0.0001) for CAL-DEP relative to FED and decreased (P < 0.0001) over time regardless of diet. In the FED state, insulin (r = 0.55), glucose (r = 0.76), cortisol (r = -0.59), and DHEA-S (r = -0.62) were associated (P < 0.05) with satiety, but not during CAL-DEP. These findings show that 2 days of severe energy restriction alter several endocrine regulators of appetite independent of perception of increased hunger suggesting a physiological mechanism to explain overeating following acute periods of severe energy restriction. C1 [Pasiakos, Stefan M.; Caruso, Christina M.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Kellogg, Mark D.] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA. [Kramer, F. Matthew] USA, Consumer Res Cognit Sci Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; Kellogg, Mark/0000-0003-1868-2153 FU U.S. Army Medical Research and Materiel Command FX This work was supported by the U.S. Army Medical Research and Materiel Command. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR part 219. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. The authors would like to acknowledge Paul Maguire and Holly McClung for the development and preparation of the hydrocolloid-based gels. We acknowledge Dr Jennifer Rood and her staff at the Pennington Biomedical Research Center for their assistance with hormone assays. We also wish to acknowledge Philip Niro for his layout and design expertise in preparation of the manuscript. NR 57 TC 15 Z9 15 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD JUN PY 2011 VL 19 IS 6 BP 1124 EP 1130 DI 10.1038/oby.2010.316 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 769NG UT WOS:000291021600003 PM 21212768 ER PT J AU Valiyaveettil, M Alamneh, Y Biggemann, L Soojhawon, I Farag, HA Agrawal, P Doctor, BP Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Biggemann, Lionel Soojhawon, Iswarduth Farag, Heba A. Agrawal, Prashasthi Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates SO TOXICOLOGY IN VITRO LA English DT Article DE Catalytic bioscavenger; Paraoxonase 1; Organophosphates; Protein purification; Nerve agents; Chemical defense ID HUMAN SERUM PARAOXONASE; NERVE AGENTS; GUINEA-PIGS; PON1 STATUS; CATALYTIC SCAVENGERS; PURIFIED HUMAN; ACTIVE-SITE; TOXICITY; RABBIT; PURIFICATION AB Paraoxonase 1 (PON1) has been described as a potential catalytic bioscavenger due to its ability to hydrolyze organophosphate (OP) insecticides and nerve agents. In vitro catalytic efficiency of purified human and rabbit serum PON1 against different OP substrates was compared to human recombinant PON1, expressed in Trichoplusia ni larvae. Highly purified human and rabbit serum PON1s were prepared by multiple chromatography methods. Purified enzymes showed higher catalytic activity with the substrate p-nitrophenyl acetate compared to diethyl paraoxon. The hydrolyzing potential of PON1s against multiple OPs was evaluated by using an in vitro acetylcholinesterase back-titration assay. Significant differences in the catalytic efficiency of all the three PON1s with regard to various OP substrates were observed. Purified PON1s showed higher catalytic activity towards diisopropylfluorophosphate followed by diethylparaoxon compared to dimethyl paraoxon. Heat inactivation or incubation of PON1 with specific inhibitor resulted in complete loss of the enzyme catalytic activity indicating that OP hydrolysis was intrinsic to PON1. In conclusion, purified PON1s from multiple sources show significant differences in the catalytic activity against several OP substrates. These results underscore the importance of systematic analysis of candidate PON1 molecules for developing as an effective catalytic bioscavenger against toxic OPs and chemical warfare nerve agents. Published by Elsevier Ltd. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Biggemann, Lionel; Soojhawon, Iswarduth; Farag, Heba A.; Agrawal, Prashasthi; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Farag, Heba A.; Agrawal, Prashasthi; Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.D0017_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.D0017_08_WR_C. NR 70 TC 8 Z9 9 U1 3 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD JUN PY 2011 VL 25 IS 4 BP 905 EP 913 DI 10.1016/j.tiv.2011.02.012 PG 9 WC Toxicology SC Toxicology GA 771ET UT WOS:000291140700018 PM 21382471 ER PT J AU Masini, BD Stinner, DJ Waterman, SM Wenke, JC AF Masini, Brendan D. Stinner, Daniel J. Waterman, Scott M. Wenke, Joseph C. TI Bacterial Adherence to High-Tensile Strength Sutures SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article ID ARTHROSCOPIC KNOTS; INFECTION; MODEL; CONTAMINATION; COMPLICATIONS AB Purpose: The purpose of this study was to evaluate the bacterial adherence to high-tensile strength suture materials using a bioluminescent in vitro model. Methods: Eleven strands each of No. 2 MaxBraid (Arthrotek [Biomet], Warsaw, IN), FiberWire (Arthrex, Naples, FL), Ethibond (Ethicon, Somerville, NJ), Orthocord (DePuy Mitek, Raynham, MA), and silk (Ethicon) sutures were immersed in a broth of bioluminescent Staphylococcus aureus, which is genetically engineered to emit photons. After 12 hours in the broth, the suture strands were individually irrigated with 10 mL of low-pressure normal saline solution and imaged with a photon-capturing camera system that yields a total photon count that correlates directly with residual bacterial counts. Results: MaxBraid had the greatest adherence, followed by FiberWire, Ethibond, Orthocord, and silk. Orthocord had only 25% of the bacterial adherence of MaxBraid (P < .001). Ethibond and FiberWire had 53% (P < .001) and 75% (P = .003) of the adherence of MaxBraid, respectively. Differences between each suture were also statistically significant, with Ethibond and Orthocord having 71% (P = .007) and 33% (P < .001) of the adherence of FiberWire, respectively, and Orthocord having 47% (P < .001) of the adherence of Ethibond. The adherence to silk was statistically lower than all of the high-tensile strength sutures. Conclusions: Among high-tensile strength sutures, Orthocord has significantly less bacterial adherence than MaxBraid and FiberWire. Although infections in arthroscopic shoulder surgery are rare, the physical properties of surgical implants should be known by surgeons. In addition, bacterial adherence may contribute to suture selection in a patient prone to infection or to the use of suture in other body areas at greater risk for contamination. Clinical Relevance: Bacterial adherence to high-tensile strength sutures may be a useful factor in implant selection in a patient with predisposition for contamination or infection. C1 [Masini, Brendan D.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Waterman, Scott M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Masini, BD (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Brendan.Masini@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 15 TC 4 Z9 4 U1 0 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD JUN PY 2011 VL 27 IS 6 BP 834 EP 838 DI 10.1016/j.arthro.2011.02.003 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 769WB UT WOS:000291047900016 PM 21624678 ER PT J AU Hunter, LE Howle, JF Rose, RS Bawden, GW AF Hunter, L. E. Howle, J. F. Rose, R. S. Bawden, G. W. TI LiDAR-Assisted Identification of an Active Fault near Truckee, California SO BULLETIN OF THE SEISMOLOGICAL SOCIETY OF AMERICA LA English DT Article ID WESTERN UNITED-STATES; SIERRA-NEVADA; RANGE PROVINCE; LAKE TAHOE; GREAT-BASIN; PLEISTOCENE GLACIATION; EASTERN CALIFORNIA; NORTHERN BASIN; DEFORMATION; EARTHQUAKE AB We use high-resolution (1.5-2.4 points/m(2)) bare-earth airborne Light Detection and Ranging (LiDAR) imagery to identify, map, constrain, and visualize fault-related geomorphology in densely vegetated terrain surrounding Martis Creek Dam near Truckee, California. Bare-earth LiDAR imagery reveals a previously unrecognized and apparently youthful right-lateral strike-slip fault that exhibits laterally continuous tectonic geomorphic features over a 35-km-long zone. If these interpretations are correct, the fault, herein named the Polaris fault, may represent a significant seismic hazard to the greater Truckee-Lake Tahoe and Reno-Carson City regions. Three-dimensional modeling of an offset late Quaternary terrace riser indicates a minimum tectonic slip rate of 0.4 +/- 0.1 mm/yr. Mapped fault patterns are fairly typical of regional patterns elsewhere in the northern Walker Lane and are in strong coherence with moderate magnitude historical seismicity of the immediate area, as well as the current regional stress regime. Based on a range of surface-rupture lengths and depths to the base of the seismogenic zone, we estimate a maximum earthquake magnitude (M) for the Polaris fault to be between 6.4 and 6.9. C1 [Hunter, L. E.; Rose, R. S.] USA, Corps Engineers, Sacramento, CA 95814 USA. [Howle, J. F.] US Geol Survey, Carnelian Bay, CA 96140 USA. [Bawden, G. W.] US Geol Survey, Sacramento, CA 95819 USA. RP Hunter, LE (reprint author), USA, Corps Engineers, Sacramento, CA 95814 USA. NR 64 TC 21 Z9 22 U1 1 U2 11 PU SEISMOLOGICAL SOC AMER PI EL CERRITO PA PLAZA PROFESSIONAL BLDG, SUITE 201, EL CERRITO, CA 94530 USA SN 0037-1106 J9 B SEISMOL SOC AM JI Bull. Seismol. Soc. Amer. PD JUN PY 2011 VL 101 IS 3 BP 1162 EP 1181 DI 10.1785/0120090261 PG 20 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 769PL UT WOS:000291029700017 ER PT J AU Chesnut, GT Maggio, KL Turiansky, GW AF Chesnut, Gregory T. Maggio, Kurt L. Turiansky, George W. TI RE: Case Series of Multiple Recurrent Reactive Keratoacanthomas Developing at Surgical Margins SO DERMATOLOGIC SURGERY LA English DT Letter C1 [Chesnut, Gregory T.] USN, Natl Capital Consortium Gen Surg, Residency Program, Bethesda, MD 20084 USA. [Turiansky, George W.] USA, Dermatol Serv, Walter Reed Army Med Ctr, Washington, DC 20310 USA. RP Chesnut, GT (reprint author), USN, Natl Capital Consortium Gen Surg, Residency Program, Bethesda, MD 20084 USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD JUN PY 2011 VL 37 IS 6 BP 884 EP 885 DI 10.1111/j.1524-4725.2011.01962.x PG 2 WC Dermatology; Surgery SC Dermatology; Surgery GA 767QO UT WOS:000290871300031 PM 21492306 ER PT J AU Acosta, RD Cash, BD AF Acosta, Ruben D. Cash, Brooks D. TI Existing and emerging therapies for irritable bowel syndrome SO EXPERT OPINION ON EMERGING DRUGS LA English DT Review DE alosetron; irritable bowel syndrome; linaclotide; lubiprostone; rifaximin; talnetant; tegaserod ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; 5-HT4 RECEPTOR AGONIST; INTESTINAL BACTERIAL OVERGROWTH; CORTICOTROPIN-RELEASING HORMONE; CELL STABILIZER KETOTIFEN; BILE-ACID MALABSORPTION; DIARRHEA-PREDOMINANT; CLINICAL-TRIAL; DOUBLE-BLIND AB Areas covered: A search of the online bibliographic databases MEDLINE and EMBASE was performed in order to identify all relevant articles published between 1980 and 2010. The search was enhanced with the use of a medical librarian. Bibliographies from potentially relevant articles were manually searched. Expert opinion: The therapeutic options for irritable bowel syndrome are rapidly evolving beyond traditional symptom-based therapies, such as fiber, antispasmodics, antidiarrheals and laxatives, and are moving toward agents with organ-specific receptor selectivity directed, in many cases, at specific gastrointestinal functions. C1 [Acosta, Ruben D.; Cash, Brooks D.] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Acosta, Ruben D.; Cash, Brooks D.] Walter Reed Army Med Ctr, Div Gastroenterol, Bethesda, MD 20889 USA. [Cash, Brooks D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cash, BD (reprint author), Natl Naval Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM brooks.cash@med.navy.mil NR 114 TC 0 Z9 0 U1 1 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1472-8214 J9 EXPERT OPIN EMERG DR JI Expert Opin Emerg. Drugs PD JUN PY 2011 VL 16 IS 2 BP 389 EP 402 DI 10.1517/14728214.2011.566214 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 768UY UT WOS:000290965100012 PM 21438740 ER PT J AU McKinney, KK Webb, L Petersen, M Nelson, M Laubach, S AF McKinney, Kristi K. Webb, Luke Petersen, Maureen Nelson, Michael Laubach, Susan TI Ovalbumin content of 2010-2011 influenza vaccines SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter ID EGG ALLERGY C1 [McKinney, Kristi K.; Webb, Luke; Petersen, Maureen; Nelson, Michael; Laubach, Susan] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. RP McKinney, KK (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. EM Kristi.mckinney@us.army.mil NR 9 TC 16 Z9 18 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JUN PY 2011 VL 127 IS 6 BP 1629 EP 1632 DI 10.1016/j.jaci.2011.02.003 PG 5 WC Allergy; Immunology SC Allergy; Immunology GA 769WH UT WOS:000291048500049 PM 21397313 ER PT J AU Stringer, DB Sheth, PN Allaire, PE AF Stringer, D. B. Sheth, P. N. Allaire, P. E. TI Modal reduction of geared rotor systems with general damping and gyroscopic effects SO JOURNAL OF VIBRATION AND CONTROL LA English DT Article DE Gearing effect; general damping systems; gyroscopic systems; modal reduction ID COORDINATE TRANSFORMATIONS; VIBRATION ANALYSIS; 2ND-ORDER SYSTEMS; BEARINGS AB The presence of damping, gyroscopic behavior, and gearing complicates traditional vibration analysis. This paper presents a methodology for conducting modal reduction on a geared rotor dynamic system under the influences of general damping and gyroscopic effects. Based on the first-order, state-space methodology, a coordinate transformation is presented for diagonalizing the state equations of motion for each substructure in the system. A modal synthesis procedure assembles the system equations from the individual substructures. The substructures are coupled via gear-mesh interactions. Using this technique, the size and complexity of a model can be reduced without incurring significant loss of accuracy. The reduced model allows for traditional methods of system analysis to include eigen-solution analysis, and frequency response. Validation occurs through application to a simple geared system widely discussed in the literature. The results of the modal reduction match closely with the full finite element model. A transmission system is also analyzed to illustrate the method's usefulness to a complex system model of multiple shafts and gear interactions. Considerations arising from the analysis of geared systems are also discussed. C1 [Stringer, D. B.] NASA, USA, Res Lab, Vehicle Technol Directorate,Glenn Res Ctr, Cleveland, OH 44135 USA. [Sheth, P. N.] Univ Virginia, Dept Mech & Aerosp Engn, Charlottesville, VA USA. RP Stringer, DB (reprint author), NASA, USA, Res Lab, Vehicle Technol Directorate,Glenn Res Ctr, MS 23-3, Cleveland, OH 44135 USA. EM david.stringer@us.army.mil RI Stringer, D. Blake/B-3051-2017 OI Stringer, D. Blake/0000-0002-4375-2638 NR 27 TC 8 Z9 9 U1 1 U2 15 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1077-5463 J9 J VIB CONTROL JI J. Vib. Control PD JUN PY 2011 VL 17 IS 7 BP 975 EP 987 DI 10.1177/1077546310372848 PG 13 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 769JB UT WOS:000291007600002 ER PT J AU Cowan, DN Bedno, SA Urban, N Yi, B Niebuhr, DW AF Cowan, D. N. Bedno, S. A. Urban, N. Yi, B. Niebuhr, D. W. TI Musculoskeletal injuries among overweight army trainees: incidence and health care utilization SO OCCUPATIONAL MEDICINE-OXFORD LA English DT Article DE armed forces; BMI; epidemiological studies; fitness tests; injury; male; musculoskeletal; obesity ID US MILITARY; OBESITY; FITNESS; CONSCRIPTS; PRIORITIES; ATTRITION; ADULTS; RATES AB Aims This study was conducted to compare the incidence of and outpatient utilization for training-related overuse injuries among men who were over body fat (OBF) standards compared with those who were weight qualified (WQ). Methods All study subjects were men >= 18 years old, who were classified as OBF or WQ and were followed for 90 days. During this period, everyone entering through the study sites was required to take a physical fitness test (5 min step test). Only individuals passing the fitness test were included in these analyses. Results There were 812 OBF and 6511 WQ study participants. OBF were 47% more likely to experience a musculoskeletal injury and had 49% higher health care utilization. Other significant factors included age > 19 and a history of smoking. Conclusions Among this population who had passed a fitness test, those who were OBF had a substantially higher risk of injury and higher utilization for these injuries. Because the recruiting environment is much better, military entrance standards have been tightened, but should the economy improve substantially the military may again be challenged to recruit adequate numbers of personnel, and the lessons learned in this project may prove valuable. C1 [Cowan, D. N.; Bedno, S. A.; Urban, N.; Yi, B.; Niebuhr, D. W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Cowan, D. N.; Urban, N.; Yi, B.] Allied Technol Grp Inc, Rockville, MD 20850 USA. [Bedno, S. A.] Dwight D Eisenhower Army Med Ctr, Occupat Hlth Clin, Ft Gordon, GA 30905 USA. RP Cowan, DN (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.cowan@amedd.army.mil RI Yi, Bin/B-7874-2011 FU United States Military Entrance Processing Command; Army Accession Command [MIPR9DDATFTM04] FX United States Military Entrance Processing Command; Army Accession Command (MIPR9DDATFTM04). NR 20 TC 22 Z9 23 U1 1 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0962-7480 J9 OCCUP MED-OXFORD JI Occup. Med.-Oxf. PD JUN PY 2011 VL 61 IS 4 BP 247 EP 252 DI 10.1093/occmed/kqr028 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 770BJ UT WOS:000291061700007 PM 21482621 ER PT J AU Dubick, MA Barr, JL Martini, WZ AF Dubick, M. A. Barr, J. L. Martini, W. Z. TI ANTIOXIDANT STATUS IN TISSUES FROM PIGS SUBJECTED TO TRAUMATIC HEMORRHAGE AND RESUSCITATION SO SHOCK LA English DT Meeting Abstract CT 34th Annual Conference on Shock CY JUN 11-14, 2011 CL Norfolk, VA C1 [Dubick, M. A.; Barr, J. L.; Martini, W. Z.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2011 VL 35 SU 1 BP 29 EP 29 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 768VG UT WOS:000290965900089 ER PT J AU Sondeen, JL DeGuzman, R Polykratis, A Prince, D McNair, SD Diaz, JE Cap, AP Dubick, MA AF Sondeen, J. L. DeGuzman, R. Polykratis, A. Prince, D. McNair, S. D. Diaz, J. E. Cap, A. P. Dubick, M. A. TI COMPARISON BETWEEN HUMAN AND PORCINE THROMBOELASTOGRAPH (TEG) MAXIMUM AMPLITUDE IN RESPONSE TO EX VIVO CHANGES TO BLOOD COMPONENT CONCENTRATIONS SO SHOCK LA English DT Meeting Abstract CT 34th Annual Conference on Shock CY JUN 11-14, 2011 CL Norfolk, VA C1 [Sondeen, J. L.; DeGuzman, R.; Polykratis, A.; Prince, D.; McNair, S. D.; Diaz, J. E.; Cap, A. P.; Dubick, M. A.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2011 VL 35 SU 1 BP 29 EP 29 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 768VG UT WOS:000290965900090 ER PT J AU Martini, WZ Cortez, D Colvin, S Dubick, MA Blackbourne, LH AF Martini, W. Z. Cortez, D. Colvin, S. Dubick, M. A. Blackbourne, L. H. TI CHANGES OF COAGULATION FACTORS, THROMBIN GENERATION AND COAGULATION FUNCTION AFTER HEMORRHAGIC SHOCK IN PIGS SO SHOCK LA English DT Meeting Abstract CT 34th Annual Conference on Shock CY JUN 11-14, 2011 CL Norfolk, VA C1 [Martini, W. Z.; Cortez, D.; Colvin, S.; Dubick, M. A.; Blackbourne, L. H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2011 VL 35 SU 1 BP 30 EP 30 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 768VG UT WOS:000290965900092 ER PT J AU Baer, LA Wu, X Pidcoke, H Wolf, SE Wade, CE AF Baer, L. A. Wu, X. Pidcoke, H. F. Wolf, S. E. Wade, C. E. TI INCREASED URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) IN RATS WITH BURNS: HIGH ASSOCIATION WITH INFLAMMATION BUT NOT RENAL INSUFFICIENCY SO SHOCK LA English DT Meeting Abstract CT 34th Annual Conference on Shock CY JUN 11-14, 2011 CL Norfolk, VA C1 [Baer, L. A.; Wu, X.; Pidcoke, H. F.; Wolf, S. E.; Wade, C. E.] Univ Texas Hlth Sci Ctr Houston, USA, Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2011 VL 35 SU 1 BP 33 EP 33 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 768VG UT WOS:000290965900101 ER PT J AU Hurst, FP Jindal, RM Fletcher, JJ Dharnidharka, V Gorman, G Lechner, B Nee, R Agodoa, LY Abbott, KC AF Hurst, Frank P. Jindal, Rahul M. Fletcher, James J. Dharnidharka, Vikas Gorman, Greg Lechner, Brent Nee, Robert Agodoa, Lawrence Y. Abbott, Kevin C. TI Incidence, Predictors and Associated Outcomes of Renal Cell Carcinoma in Long-term Dialysis Patients SO UROLOGY LA English DT Review ID ACQUIRED CYSTIC-DISEASE; KIDNEY-DISEASE; UNITED-STATES; TRANSPLANTATION; CANCER; CT AB We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors and prognosis of renal cell carcinoma (RCC) in a national population of patients receiving incident long-term dialysis. In Cox regression, male gender, older age, end-stage renal disease caused by obstruction, tuberous sclerosis, focal segmental glomerulosclerosis, as well as acquired renal cysts, were independently associated with RCC. Most cases of RCC in incident long-term dialysis patients occurred in patients without acquired renal cysts. A diagnosis of RCC was associated with increased risk of subsequent mortality overall and in all high-risk groups. UROLOGY 77: 1271-1276, 2011. Published by Elsevier Inc. C1 [Jindal, Rahul M.] Walter Reed Army Med Ctr, Dept Organ Transplantat, Serv Nephrol, Washington, DC 20307 USA. Portsmouth Naval Hosp, Serv Nephrol, Portsmouth, VA USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Gainesville, FL USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. George Washington Univ, Dept Med, Washington, DC USA. Univ Florida, Gainesville, FL USA. NIDDK, NIH, Bethesda, MD USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Dept Organ Transplantat, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 23 TC 15 Z9 15 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JUN PY 2011 VL 77 IS 6 BP 1271 EP 1276 DI 10.1016/j.urology.2011.01.007 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 769VX UT WOS:000291047500003 PM 21459420 ER PT J AU Weiss, BM Minter, A Abadie, J Howard, R Ascencao, J Schechter, GP Kuehl, M Landgren, O AF Weiss, Brendan M. Minter, Alex Abadie, Jude Howard, Robin Ascencao, Joao Schechter, Geraldine P. Kuehl, Michael Landgren, Ola TI Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article ID ASYMPTOMATIC MULTIPLE-MYELOMA; INDEPENDENT RISK-FACTOR; NON-HODGKINS-LYMPHOMA; UNITED-STATES; WALDENSTROM MACROGLOBULINEMIA; REFERENCE INTERVALS; ADULT-POPULATION; WORKING GROUP; LONG-TERM; FOLLOW-UP AB Monoclonal gammopathy of undetermined significance (MGUS), the precursor to multiple myeloma, is more common in blacks than whites. The serum free light chain (sFLC) assay is an important prognostic test in MGUS, but no study has evaluated sFLC levels and ratios in black MGUS patients. One-hundred and twenty-five black MGUS patients at two urban centers were compared to the white population of the Mayo Clinic. The median age for blacks was 73 years [41-94] and 75% were male. The M-protein isotype in blacks was 81% IgG, 13% IgA, 2% IgM, and 4% biclonal compared to 70%, 12%, 16%, and 2%, respectively, in whites, (P < 0.0005). The median M-protein concentration for blacks was 0.44 gm/dL (trace-2.33) compared to 1.2 gm/dl in whites. An abnormal sFLC ratio was present in 45% of black compared to 33% of white (P = 0.01) patients. Using the Mayo Clinic risk model, black patients had a significantly lower proportion of higher risk MGUS compared to whites: low 43%, low-intermediate 45%, high-intermediate 10%, and high 2% (P = 0.014). Black patients with MGUS have significantly different laboratory findings compared to whites. The biologic basis for these disparities and their effect on prognostic assessment is unknown. Prognostic models based on these biomarkers should be used cautiously in nonwhite populations. Am. J. Hematol. 86:475-478, 2011. (C) 2011 Wiley-Liss, Inc. C1 [Weiss, Brendan M.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. [Abadie, Jude] Brooke Army Med Ctr, Pathol Serv, San Antonio, TX USA. [Abadie, Jude] Brooke Army Med Ctr, Area Lab Serv, San Antonio, TX USA. [Ascencao, Joao; Schechter, Geraldine P.] Washington Vet Affairs Med Ctr, Hematol Sect, Washington, DC USA. [Ascencao, Joao; Schechter, Geraldine P.] George Washington Univ, Washington, DC USA. [Kuehl, Michael] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA. [Landgren, Ola] NCI, Med Oncol Branch, NIH, Bethesda, MD 20892 USA. RP Weiss, BM (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM brendan.weiss@us.army.mil FU Binding Site, Inc. FX Contract grant sponsors: The Binding Site, Inc. NR 44 TC 20 Z9 20 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 2011 VL 86 IS 6 BP 475 EP 478 DI 10.1002/ajh.22025 PG 4 WC Hematology SC Hematology GA 766CI UT WOS:000290757400003 PM 21544856 ER PT J AU Louie, A VanScoy, B Liu, WG Kulawy, R Brown, D Heine, HS Drusano, GL AF Louie, Arnold VanScoy, Brian Liu, Weiguo Kulawy, Robert Brown, David Heine, Henry S. Drusano, George L. TI Comparative Efficacies of Candidate Antibiotics against Yersinia pestis in an In Vitro Pharmacodynamic Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PNEUMONIC PLAGUE; BACILLUS-ANTHRACIS; RESISTANCE; INFECTION; THERAPY AB Yersinia pestis, the bacterium that causes plague, is a potential agent of bioterrorism. Streptomycin is the "gold standard" for the treatment of plague infections in humans, but the drug is not available in many countries, and resistance to this antibiotic occurs naturally and has been generated in the laboratory. Other antibiotics have been shown to be active against Y. pestis in vitro and in vivo. However, the relative efficacies of clinically prescribed regimens of these antibiotics with streptomycin and with each other for the killing of Yersinia pestis are unknown. The efficacies of simulated pharmacokinetic profiles for human 10-day clinical regimens of ampicillin, meropenem, moxifloxacin, ciprofloxacin, and gentamicin were compared with the gold standard, streptomycin, for killing of Yersinia pestis in an in vitro pharmacodynamic model. Resistance amplification with therapy was also assessed. Streptomycin killed the microbe in one trial but failed due to resistance amplification in the second trial. In two trials, the other antibiotics consistently reduced the bacterial densities within the pharmacodynamic systems from 10(8) CFU/ml to undetectable levels (<10(2) CFU/ml) between 1 and 3 days of treatment. None of the comparator agents selected for resistance. The comparator antibiotics were superior to streptomycin against Y. pestis and deserve further evaluation. C1 [Louie, Arnold; VanScoy, Brian; Liu, Weiguo; Kulawy, Robert; Brown, David; Drusano, George L.] Ordway Res Inst, Ctr Biodef & Emerging Infect, Albany, NY 12208 USA. [Heine, Henry S.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Louie, A (reprint author), Ordway Res Inst, Ctr Biodef & Emerging Infect, 150 New Scotland Ave, Albany, NY 12208 USA. EM alouie@ordwayresearch.org FU NIAID [P01AI060908] FX This work was supported by P01AI060908, a grant from NIAID to the Emerging Infections and Pharmacodynamics Laboratory (G. L. Drusano). NR 27 TC 6 Z9 6 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2011 VL 55 IS 6 BP 2623 EP 2628 DI 10.1128/AAC.01374-10 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 765NA UT WOS:000290713400019 PM 21486959 ER PT J AU Cloran, F Bui-Mansfield, LT AF Cloran, F. Bui-Mansfield, L. T. TI Extracranial epidural emphysema: pathway, aetiology, diagnosis and management SO BRITISH JOURNAL OF RADIOLOGY LA English DT Review ID GAS; PNEUMOMEDIASTINUM; PNEUMOPERICARDIUM; PNEUMORRHACHIS; PNEUMATOSIS AB Extracranial epidural emphysema is an uncommon phenomenon that refers to the presence of gas within the epidural space. As an isolated finding, it is typically benign, but it can be a secondary sign of more ominous disease processes, such as pneumothorax, pneumoperitoneum and epidural abscess. Although the phenomenon has been cited in case reports, a comprehensive review of this topic is lacking in the radiology literature. The authors' aim is to report our experience with extracranial epidural emphysema, illustrating the spectrum of its clinical presentation. We also review the aetiology, pathophysiology, diagnosis and management of extracranial epidural emphysema. C1 [Cloran, F.; Bui-Mansfield, L. T.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. [Bui-Mansfield, L. T.] Wake Forest Univ, Dept Radiol, Winston Salem, NC 27109 USA. [Bui-Mansfield, L. T.] USUHS, Dept Radiol, Bethesda, MD USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78258 USA. EM liem.mansfield@gmail.com NR 18 TC 3 Z9 3 U1 0 U2 1 PU BRITISH INST RADIOLOGY PI LONDON PA 36 PORTLAND PLACE, LONDON W1N 4AT, ENGLAND SN 0007-1285 J9 BRIT J RADIOL JI Br. J. Radiol. PD JUN PY 2011 VL 84 IS 1002 BP 570 EP 575 DI 10.1259/bjr/79263160 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 767HU UT WOS:000290847100016 PM 21343323 ER PT J AU Kunz, AN Rajnik, M AF Kunz, Anjali N. Rajnik, Michael TI Disseminated Cutaneous Varicella Zoster Virus Infections During Infliximab Therapy for Crohn's Disease: Case Report of Two Pediatric Patients at One Institution SO CLINICAL PEDIATRICS LA English DT Article ID ALPHA ANTAGONISTS; HERPES-ZOSTER C1 [Kunz, Anjali N.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Kunz, Anjali N.; Rajnik, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kunz, AN (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 5207 Elsmere Ave, Bethesda, MD 20814 USA. EM akunz@usuhs.mil NR 5 TC 7 Z9 7 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD JUN PY 2011 VL 50 IS 6 BP 559 EP 561 DI 10.1177/0009922810380452 PG 3 WC Pediatrics SC Pediatrics GA 763US UT WOS:000290585800014 PM 20837619 ER PT J AU Rajabalinejad, M Demirbilek, Z AF Rajabalinejad, M. Demirbilek, Z. TI Bayesian Monte Carlo method for monotonic models applying the Generalized Beta distribution SO ENGINEERING FAILURE ANALYSIS LA English DT Article DE Bayesian Mente Carlo; Dynamic Bounds; Generalized Beta distribution; Global uncertainty AB A novel Bayesian Monte Carlo method for monotonic models (BMCM) is described in this paper. The BMCM method enjoys the advantages of the recently developed method of Dynamic Bounds [1] for the reliability assessment of monotonic models, and incorporates weighted logical dependence between neighboring points of the limit state equation (LSE) as prior information for improving computational speed. The BMCM benefits from the global uncertainty concept that links global and local uncertainties. This integrated approach is superior to other techniques used in safety assessment of monotonic models as it substantially increases the efficiency of Monte Carlo method. The formulation of BMCM is provided in this paper with an example showing its ability to dramatically improve efficiency of simulations. This is achieved by employing prior information obtained from monotonic models and outcomes of the preceding simulations. The theory and numerical algorithms of the BMCM method for multi-dimensional problems, and integration with a probabilistic finite element model, are discussed in this paper. These coupled models are applied to the 17th Street Flood Wall in New Orleans to assess reliability of a flood defence system. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Rajabalinejad, M.] Delft Univ Technol TUDelft, Dept Design Engn, NL-2628 CE Delft, Netherlands. [Demirbilek, Z.] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Rajabalinejad, M (reprint author), Delft Univ Technol TUDelft, Dept Design Engn, NL-2628 CE Delft, Netherlands. EM M.Rajabalinejad@tudelft.nl NR 18 TC 1 Z9 1 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1350-6307 J9 ENG FAIL ANAL JI Eng. Fail. Anal. PD JUN PY 2011 VL 18 IS 4 BP 1153 EP 1161 DI 10.1016/j.engfailanal.2010.09.009 PG 9 WC Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA 768FW UT WOS:000290920100002 ER PT J AU Bennett, ER Steevens, JA Lotufo, GR Paterson, G Drouillard, KG AF Bennett, Erin R. Steevens, Jeffery A. Lotufo, Guilherme R. Paterson, Gord Drouillard, Ken G. TI NOVEL CONTROL AND STEADY-STATE CORRECTION METHOD FOR STANDARD 28-DAY BIOACCUMULATION TESTS USING NEREIS VIRENS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Biota sediment accumulation factor; Nereis virens; Polychlorinated biphenyl; Pulse-chase; Sediment ID FRESH-WATER MUSSEL; POLYCYCLIC AROMATIC-HYDROCARBONS; SEDIMENT-ASSOCIATED CONTAMINANTS; POLYCHLORINATED-BIPHENYLS PCBS; ELLIPTIO-COMPLANATA; ORGANIC CONTAMINANTS; LUMBRICULUS-VARIEGATUS; DEPENDENT ELIMINATION; ACCUMULATION FACTORS; MACOMA-NASUTA AB Evaluation of dredged material for aquatic placement requires assessment of bioaccumulation potentials for benthic organisms using standardized laboratory bioaccumulation tests. Critical to the interpretation of these data is the assessment of steady state for bioaccumulated residues needed to generate biota sediment accumulation factors (BSAFs) and to address control correction of day 0 contaminant residues measured in bioassay organisms. This study applied a novel performance reference compound approach with a pulse-chase experimental design to investigate elimination of a series of isotopically labeled polychlorinated biphenyl (C-13-PCBs) in the polychaete worm Nereis virens while simultaneously evaluating native PCB bioaccumulation from field-collected sediments. Results demonstrated that all C-13-PCBs, with the exception of C-13-PCB209 (> 80%), were eliminated by more than 90% after 28 d. The three sediment types yielded similar C-13-PCB whole-body elimination rate constants (k(tot)) producing the following predictive equation: log k(tot) = -0.09 x log K-OW -0.45. The rapid loss of C-13-PCBs from worms over the bioassay period indicated that control correction, by subtracting day 0 residues, would result in underestimates of bioavailable sediment residues. Significant uptake of native PCBs was observed only in the most contaminated sediment and proceeded according to kinetic model predictions with steady-state BSAFs ranging from 1 to 3 and peaking for congeners of log K-OW between 6.2 and 6.5. The performance reference compound approach can provide novel information about chemical toxicokinetics and also serve as a quality check for the physiological performance of the bioassay organism during standardized bioaccumulation testing. Environ. Toxicol. Chem. 2011;30:1366-1375. (C) 2011 SETAC C1 [Bennett, Erin R.] Bioengn Grp, Salem, MA USA. [Bennett, Erin R.; Paterson, Gord; Drouillard, Ken G.] Univ Windsor, Great Lakes Inst Environm Res, Windsor, ON N9B 3P4, Canada. [Steevens, Jeffery A.; Lotufo, Guilherme R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Bennett, ER (reprint author), Bioengn Grp, Salem, MA USA. EM ebennett@bioengineering.com FU U.S. Army Corps of Engineers (USACE) New York District (Monte Greges); USACE Engineer Research and Development Center Dredging Operations and Environmental Research FX The present study was supported in part by the U.S. Army Corps of Engineers (USACE) New York District (Monte Greges) and USACE Engineer Research and Development Center Dredging Operations and Environmental Research (Todd Bridges, Program Manager). The authors acknowledge Jerre Sims for laboratory support and David Qiu for analytical support. Permission was granted by the Chief of Engineers to present these research results. NR 53 TC 1 Z9 1 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUN PY 2011 VL 30 IS 6 BP 1366 EP 1375 DI 10.1002/etc.520 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 766ZN UT WOS:000290825200017 PM 21381091 ER PT J AU Goldman, KN Moon, KS Yauger, BJ Payson, MD Segars, JH Stegmann, BJ AF Goldman, Kara N. Moon, Kimberly S. Yauger, Belinda J. Payson, Mark D. Segars, James H. Stegmann, Barbara J. TI Proficiency in oocyte retrieval: how many procedures are necessary for training? SO FERTILITY AND STERILITY LA English DT Article DE Follicular aspiration; fellowship; competency; learning curve ID IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; RELIABILITY; RESIDENTS; SKILLS; CURVE AB Objective: To determine a minimum number of procedures required for proficiency in oocyte retrieval and to characterize skill acquisition. Design: Retrospective analysis. Setting: Reproductive endocrinology and infertility fellowship training program. Subject(s): Fellows in training from 2005 to 2007 and 2008 to 2010. Intervention(s): None. Main Outcome Measure(s): Proficiency scores were calculated by dividing the number of oocytes retrieved by oocytes expected. The 2005 to 2007 trainees were grouped and proficiency scores calculated as an average during specific points in their training. The 2008 to 2010 trainees were compared individually to determine differences in individual skill acquisition. Result(s): A greater number of oocytes were retrieved than expected, 8.6 versus 7.6. A relatively lower proficiency score was noted during the first 10 trainee aspirations (proficiency score 1.1) compared with subsequent aspirations (proficiency score = 1.25 for retrievals 11-20, proficiency score = 1.21 for retrievals 21-30 and > 31). When individual fellows' scores were calculated, the majority achieved proficiency by 20 aspirations, and all but one trainee achieved the mean staff proficiency score by 50 retrievals. Conclusion(s): Regardless of a trainee's initial proficiency in oocyte retrieval, there were no statistically significant differences in the learning curve between trainees. The majority of individual fellows in training demonstrate proficiency in follicular aspirations within 20 procedures; however, a minority may require 50 procedures to achieve the proficiency of an attending physician. (Fertil Steril (R) 2011; 95: 2279-82. (C) 2011 by American Society for Reproductive Medicine.) C1 [Stegmann, Barbara J.] Univ Iowa Hosp & Clin, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Iowa City, IA 52246 USA. [Goldman, Kara N.; Moon, Kimberly S.; Yauger, Belinda J.; Payson, Mark D.; Segars, James H.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA. [Goldman, Kara N.] Northwestern Univ, Prentice Womens Hosp, Dept Obstet & Gynecol, Chicago, IL 60611 USA. [Payson, Mark D.] Walter Reed Army Med Ctr, Assisted Reprod Technol Program, Div Reprod Endocrinol & Infertil, Washington, DC 20307 USA. RP Stegmann, BJ (reprint author), Univ Iowa Hosp & Clin, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, 200 Hawkins Dr,31324 PFP, Iowa City, IA 52246 USA. EM Barbara-Stegmann@uiowa.edu OI Goldman, Kara/0000-0002-5455-627X FU National Institutes of Health; National Institute of Child Health and Human Development FX Supported by the Intramural Research Program of the National Institutes of Health, Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development. NR 16 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUN PY 2011 VL 95 IS 7 BP 2279 EP 2282 DI 10.1016/j.fertnstert.2011.02.055 PG 4 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 766NT UT WOS:000290791000051 PM 21457969 ER PT J AU Walker, DM Tordesillas, A Thornton, C Behringer, RP Zhang, J Peters, JF AF Walker, David M. Tordesillas, Antoinette Thornton, Colin Behringer, Robert P. Zhang, Jie Peters, John F. TI Percolating contact subnetworks on the edge of isostaticity SO GRANULAR MATTER LA English DT Article DE Complex networks; Spanning trees; Force chains; Force cycles; Isostatic ID GRANULAR-MATERIALS; SHEAR; MEDIA; DEFORMATION; SIMULATIONS; TRANSITION; SYSTEMS; STRESS AB We search for a percolating, strong subnetwork of contacts in a quasi-statically deforming, frictional granular material. Of specific interest in this study is that subnetwork which contributes to the majority of the total deviator stress and is, or is on the edge of being, isostatic. We argue that a subnetwork derived from the minimal spanning trees of a graph-optimized to include as many elastic contacts as possible and which bear normal contact forces above a given threshold delivers such a network. Moreover adding the strong 3-force-cycles to the spanning tree introduces a level of redundancy required to achieve a network that is almost if not isostatic. Results are shown for assemblies of non-uniformly sized circular particles under biaxial compression, in two-dimensions: a discrete element (DEM) simulation of monotonic loading under constant confining pressure, and cyclic loading of photoelastic disks under constant volume. C1 [Walker, David M.; Tordesillas, Antoinette] Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. [Thornton, Colin] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England. [Behringer, Robert P.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Zhang, Jie] Los Alamos Natl Lab, CNLS MPA CMMS, Los Alamos, NM 87545 USA. [Peters, John F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Tordesillas, A (reprint author), Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. EM atordesi@ms.unimelb.edu.au RI Zhang, Jie/O-2127-2015; Walker, David/Q-1995-2016 OI Walker, David/0000-0001-9322-6743 FU US Army Research Office [W911NF-07-1-0131, W911NF-07-1-0370]; Australian Research Council [DP0986876, DP0772409]; US NSF [DMR0906908] FX We thank Fernando Alonso-Marroquin and our reviewers for their insightful comments and assistance which have significantly improved the paper. This study was supported by the US Army Research Office (W911NF-07-1-0131 for RPB, W911NF-07-1-0370 for AT) and the Australian Research Council (DP0986876 and DP0772409 for AT) and the US NSF (DMR0906908 for RPB). NR 31 TC 10 Z9 10 U1 1 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1434-5021 J9 GRANUL MATTER JI Granul. Matter PD JUN PY 2011 VL 13 IS 3 SI SI BP 233 EP 240 DI 10.1007/s10035-011-0250-y PG 8 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA 765AX UT WOS:000290676900010 ER PT J AU Chen, Y Nasrabadi, NM Tran, TD AF Chen, Yi Nasrabadi, Nasser M. Tran, Trac D. TI Sparse Representation for Target Detection in Hyperspectral Imagery SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Hyperspectral imagery; sparse recovery; sparse representation; spatial correlation; target detection ID MATCHED-FILTER; SUBSPACE DETECTORS; PURSUIT; CLASSIFICATION; RECOGNITION; EQUATIONS; SUPPORT; SYSTEMS; ADVENT; BASES AB In this paper, we propose a new sparsity-based algorithm for automatic target detection in hyperspectral imagery (HSI). This algorithm is based on the concept that a pixel in HSI lies in a low-dimensional subspace and thus can be represented as a sparse linear combination of the training samples. The sparse representation (a sparse vector corresponding to the linear combination of a few selected training samples) of a test sample can be recovered by solving an l(0)-norm minimization problem. With the recent development of the compressed sensing theory, such minimization problem can be recast as a standard linear programming problem or efficiently approximated by greedy pursuit algorithms. Once the sparse vector is obtained, the class of the test sample can be determined by the characteristics of the sparse vector on reconstruction. In addition to the constraints on sparsity and reconstruction accuracy, we also exploit the fact that in HSI the neighboring pixels have a similar spectral characteristic (smoothness). In our proposed algorithm, a smoothness constraint is also imposed by forcing the vector Laplacian at each reconstructed pixel to be minimum all the time within the minimization process. The proposed sparsity-based algorithm is applied to several hyperspectral imagery to detect targets of interest. Simulation results show that our algorithm outperforms the classical hyperspectral target detection algorithms, such as the popular spectral matched filters, matched subspace detectors, adaptive subspace detectors, as well as binary classifiers such as support vector machines. C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. EM ychen98@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu FU Army Research Office (ARO) [58110-MA-II]; National Science Foundation (NSF) [CCF-0728893] FX This paper was supported in part by the Army Research Office (ARO) under Grant 58110-MA-II and in part by the National Science Foundation (NSF) under Grant CCF-0728893. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Gustavo Camps-Valls. NR 40 TC 95 Z9 112 U1 7 U2 28 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-4553 EI 1941-0484 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD JUN PY 2011 VL 5 IS 3 BP 629 EP 640 DI 10.1109/JSTSP.2011.2113170 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA 766AN UT WOS:000290750700023 ER PT J AU Abu Obaid, A Deitzel, JM Gillespie, JW Zheng, JQ AF Abu Obaid, A. Deitzel, J. M. Gillespie, J. W., Jr. Zheng, J. Q. TI The effects of environmental conditioning on tensile properties of high performance aramid fibers at near-ambient temperatures SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE aramid fibers; hygrothermal degradation; Armos (R) fibers ID POLYMERIZED POLY(P-PHENYLENE TEREPHTHALAMIDE); DIFFERENTIAL WATER SORPTION; AROMATIC POLYAMIDE FIBERS; KEVLAR 49 FIBERS; MECHANICAL-PROPERTIES; CRYSTAL-STRUCTURE; SPECTROSCOPY; DIFFUSION; DYNAMICS; MOISTURE AB Aramid and aramid copolymer fibers are used in a wide variety of military and civilian applications; however, the long-term effects of environmental exposure on tensile properties are still not well understood. The current effort investigates the effect of hygrothermal conditioning on the tensile properties of Kevlar (R) KM2 (R), Twaron (R), and the newly available Russian copolymer, Armos (R) high performance fibers. Moisture uptake studies show that at room temperature, water diffuses more slowly into the copolymer Armos (R) (D = 8.7 x 10(-13) cm(2)/s) compared to the Kevlar (R) KM2 (R) and Twaron (R) homopolymers (D = 2.16 x 10(-12) cm(2)/s and D = 1.8 x 10 (-12) cm(2)/s, respectively). Tensile properties have been measured for these aramid fibers that have been conditioned in water at 40 degrees C, 60 degrees C, 80 degrees C, and 100 degrees C for periods of 17 and 34 days. For both aramid and aramid copolymer fibers, hygrothermal conditioning did not significantly change fiber tensile properties below 80 degrees C. At the most extreme condition of 100 degrees C, 34 days, aramid fibers showed significant loss of tensile strength (58% for KM2 and 34% for Twaron (R)), while a reduction in tensile strength of 13% (Armos (R)) was observed for aramid copolymer (Armos (R)) fibers. Conditioned fibers exhibited no significant change in mass as a result of the conditioning procedure and FTIR spectroscopy results did not indicate signs of chemical or thermo-oxidative change due to hygrothermal conditioning. These results suggest that in aramid fibers, the primary mechanism of degradation at temperatures between 80 degrees C and 100 degrees C is due to the ingress and egress of moisture in the highly ordered core structure of the fiber. The presence of water in the intercrystalline regions of the fiber core enable segmental chain motion that can relax tie molecules, alter crystal orientation, and change apparent crystallite size. Because of differences in molecular architecture and phase morphology, the aramid copolymer, Armos (R), is less susceptible to degradation of tensile properties under these conditions. C1 [Abu Obaid, A.; Deitzel, J. M.; Gillespie, J. W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gillespie, J. W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, J. W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Zheng, J. Q.] USA, Execut Program Off Soldier, Haymarket, VA 20169 USA. RP Deitzel, JM (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM jdeitzel@udel.edu FU US Army Program Executive Office: Soldier and the Army Research Laboratory [W911NF-06-2-011] FX The authors would like to thank Dr Andreas Leal at the Voith Materials GmbH & Co. KG for his help with plasma etching and microscopy, as well as Dr Serge Lopatnikov at the UD-CCM and the Khimvlokno Scientific-Industrial Association for providing samples of Armos (R) fiber for testing. Research was sponsored by the US Army Program Executive Office: Soldier and the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 33 TC 8 Z9 8 U1 5 U2 37 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD JUN PY 2011 VL 45 IS 11 BP 1217 EP 1231 DI 10.1177/0021998310381436 PG 15 WC Materials Science, Composites SC Materials Science GA 768BE UT WOS:000290905500007 ER PT J AU Hegg, R Lee, AG Tagg, NT Zimmerman, MB AF Hegg, Ryan Lee, Andrew G. Tagg, Nathan T. Zimmerman, M. Bridget TI Statin or Nonsteroidal Anti-Inflammatory Drug Use Is Associated With Lower Erythrocyte Sedimentation Rate in Patients With Giant Cell Arteritis SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Article ID C-REACTIVE PROTEIN; RHEUMATOID-ARTHRITIS; DISEASE-ACTIVITY AB Background: Previous studies have found that nonsteroidal anti-inflammatory drugs (NSAIDs) and statins may impact erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) levels in patients. The current study was performed to determine if NSAID or statin use is associated with lower ESR and CRP in patients with biopsy-proven giant cell arteritis (GCA). Methods: A retrospective cross-sectional study was conducted that included 161 patients via chart review. Charts of patients with GCA seen at the University of Iowa Hospitals and Clinics from 1960 to 2008 were reviewed. Inclusion criteria were adequate medication records, serum ESR and/or CRP on record, no prior corticosteroid use, and biopsy-positive GCA. Exclusion criteria were the presence of diseases known to elevate ESR or CRP. Main outcome measures included ESR and CRP values measured while evaluating patients for GCA but prior to receiving treatment. Results: Statin nonusers had an ESR of 85.0 mm per hour (interquartile range [IQR] = 60-110 mm per hour) and a CRP of 8.7 mg/dL (IQR = 2.7-16.2 mg/dL). Statin users had an ESR of 57.5 mm per hour (IQR = 35-85) and a CRP of 2.4 mg/dL (IQR = 0.8-15.9 mg/dL). Statin use was associated with a lower ESR (P = 0.005), while there was no significant association with a lower CRP (P = 0.127). NSAID nonusers had an ESR of 98.0 mm per hour (IQR = 64-116) and a CRP of 8.7 mg/dL (IQR = 2.1-16.2 mg/dL). NSAID users had an ESR of 75.0 mm per hour (IQR = 46-98.5 mm per hour) and CRP of 8.0 mg/dL (IQR. = 1.5-16.2 mg/dL). NSAID use was associated with a lower ESR (P = 0.004), but there was no significant association with a lower CRP (P = 0.522). Conclusion: Statin use and NSAID use were associated with a lower ESR; however, they were not associated with lower CRP values. Clinicians should be aware that statin or NSAID use is associated with lower ESR in patients with GCA, and this test may therefore have lower sensitivity and specificity for recognizing patients with GCA, and CRP may be a superior test to evaluate patients for GCA. C1 [Hegg, Ryan] Univ Iowa, Roy J & Lucille A Carver Coll Med, Iowa City, IA USA. [Lee, Andrew G.] Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA. [Tagg, Nathan T.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Zimmerman, M. Bridget] Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA USA. RP Lee, AG (reprint author), 6560 Fannin St,Scurlock 2100, Houston, TX 77030 USA. EM aglee@tmhs.org NR 13 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-8022 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD JUN PY 2011 VL 31 IS 2 BP 135 EP 138 DI 10.1097/WNO.0b013e31820c4421 PG 4 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA 766LO UT WOS:000290784000009 PM 21358421 ER PT J AU Ely, BR Cheuvront, SN Kenefick, RW Sawka, MN AF Ely, Brett R. Cheuvront, Samuel N. Kenefick, Robert W. Sawka, Michael N. TI Limitations of Salivary Osmolality as a Marker of Hydration Status SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE DEHYDRATION; FLUID INTAKE; HYPOHYDRATION; PLASMA OSMOLALITY ID BIOLOGICAL VARIATION; ACUTE DEHYDRATION; EXERCISE; FLUID; INDEXES; THIRST AB ELY, B. R., S. N. CHEUVRONT, R. W. KENEFICK, and M. N. SAWKA. Limitations of Salivary Osmolality as a Marker of Hydration Status. Med. Sci. Sports Exerc., Vol. 43, No. 6, pp. 1080-1084, 2011. Salivary osmolality (S(osm)) is a potentially useful hydration marker but may be confounded by oral artifacts. Purpose: This study aimed to determine the efficacy of Sosm for detecting hypohydration and evaluate the effect of a simple mouth rinse. Methods: Eight healthy volunteers (six males and two females; age = 22 +/- 7 yr, body mass = 83.7 +/- 14.9 kg, height = 176.9 +/- 9.2 cm) were measured for nude body mass (BM), plasma osmolality (P(osm)), and S(osm) when euhydrated (EUH) and again when hypohydrated (HYP) by exercise-heat exposure with fluid restriction. After the initial saliva sample during HYP, a 10-s mouth rinse with 50 mL of water was provided, and saliva samples were obtained 1 min (RIN01), 15 min (RIN15), and 30 min (RIN30) after rinse. The ability of S(osm) to detect HYP was compared with P(osm). Results: Volunteers were hypohydrated by -4.0% +/- 1.2% of BM (range = -2.2% to -5.3%). S(osm) was elevated above EUH after hypohydration (EUH 58 +/- 8 mmol.kg(-1) vs HYP 96 +/- 28 mmol.kg(-1), P < 0.05). S(osm) baseline and change values displayed more variability than P(osm) based on ANOVA and regression analyses. After the oral rinse, saliva decreased in concentration (RIN01 = 61 +/- 17 mmol.kg(-1), P < 0.05) but returned to prerinse values within 15 min (RIN15 = 101 +/- 25 mmol.kg(-1)) and remained similar 30 min after (RIN30 = 103 +/- 33 mmol.kg(-1)). Conclusions: S(osm) was remarkably altered 1 min after a brief water mouth rinse. Fifteen minutes proved an adequate recovery time, indicating that the timing of oral artifacts and saliva sample collection is critical when considering Sosm for hydration assessment. Given the inherent variability and profound effect of oral intake, use of S(osm) as a marker of hydration status is dubious. C1 [Ely, Brett R.; Cheuvront, Samuel N.; Kenefick, Robert W.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Ely, BR (reprint author), USARIEM, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Brett.ely@us.army.mil NR 21 TC 14 Z9 14 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 2011 VL 43 IS 6 BP 1080 EP 1084 DI 10.1249/MSS.0b013e3182058643 PG 5 WC Sport Sciences SC Sport Sciences GA 764TW UT WOS:000290657300021 PM 21088626 ER PT J AU Bozue, J Mou, S Moody, KL Cote, CK Trevino, S Fritz, D Worsham, P AF Bozue, Joel Mou, Sherry Moody, Krishna L. Cote, Christopher K. Trevino, Sylvia Fritz, David Worsham, Patricia TI The role of the phoPQ operon in the pathogenesis of the fully virulent CO92 strain of Yersinia pestis and the IP32953 strain of Yersinia pseudotuberculosis SO MICROBIAL PATHOGENESIS LA English DT Article DE Yersinia pestis; Yersinia pseudotuberculosis; phoP; phoQ; Macrophages; Plague ID RESPONSE REGULATOR PHOP; MOUSE PERITONEAL-MACROPHAGES; SALMONELLA-TYPHIMURIUM; PLASMINOGEN-ACTIVATOR; BIOFILM FORMATION; ESCHERICHIA-COLI; PNEUMONIC PLAGUE; BUBONIC PLAGUE; F1 CAPSULE; INFECTION AB At the genomic level, Yersinia pestis and Yersinia pseudotuberculosis are nearly identical but cause very different diseases. Y. pestis is the etiologic agent of plague; whereas Y. pseudotuberculosis causes a gastrointestinal infection primarily after the consumption of contaminated food. In many gram-negative pathogenic bacteria, PhoP is part of a two-component global regulatory system in which PhoQ serves as the sensor kinase, and PhoP is the response regulator. PhoP is known to activate a number of genes in many bacteria related to virulence. To determine the role of the PhoPQ proteins in Yersinia infections, primarily using aerosol challenge models, the phoP gene was deleted from the chromosome of the CO92 strain of Y. pestis and the IP32953 strain of Y. pseudotuberculosis, leading to a polar mutation of the phoPQ operon. We demonstrated that loss of phoPQ from both strains leads to a defect in intracellular growth and/or survival within macrophages. These in vitro data would suggest that the phoPQ mutants would be attenuated in vivo. However, the LD50 for the Y. pestis mutant did not differ from the calculated LD50 for the wild-type CO92 strain for either the bubonic or pneumonic murine models of infection. In contrast, mice challenged by aerosol with the Y. pseudotuberculosis mutant had a LD50 value 40x higher than the wild-type strain. These results demonstrate that phoPQ are necessary for full virulence by aerosol infection with the IP32953 strain of Y. pseudotuberculosis. However, the PhoPQ proteins do not play a significant role in infection with a fully virulent strain of Y. pestis. Published by Elsevier Ltd. C1 [Bozue, Joel; Mou, Sherry; Moody, Krishna L.; Cote, Christopher K.; Trevino, Sylvia; Fritz, David; Worsham, Patricia] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bozue, J (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM joel.a.bozue@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD [1.1A0021_07_RD_B] FX We thank Heather Schmadel, George Rush, Anthony Bassett, and Steve Tobery for their technical assistance; Hank Heine and Jennifer Bassett for advice in performing the antimicrobial sensitivity assays, Sarah Norris and Diane Fisher for completing the statistical analysis; and Susan Welkos and Brad Stiles for helpful comments and review of this manuscript. The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD project 1.1A0021_07_RD_B. NR 54 TC 23 Z9 24 U1 1 U2 5 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD JUN PY 2011 VL 50 IS 6 BP 314 EP 321 DI 10.1016/j.micpath.2011.02.005 PG 8 WC Immunology; Microbiology SC Immunology; Microbiology GA 767GJ UT WOS:000290843000006 PM 21320584 ER PT J AU Toblin, RL Mack, KA Perveen, G Paulozzi, LJ AF Toblin, Robin L. Mack, Karin A. Perveen, Ghazala Paulozzi, Leonard J. TI A population-based survey of chronic pain and its treatment with prescription drugs SO PAIN LA English DT Article DE Epidemiology; Opioid analgesics; Risk factors; Pain measurement ID CHRONIC NONCANCER PAIN; PERSISTENT PAIN; UNITED-STATES; OPIOIDS; EPIDEMIOLOGY; COMMUNITY; OVERDOSE; PREVALENCE; GUIDELINES; MANAGEMENT AB Chronic pain is a common reason for medical visits, but prevalence estimates vary between studies and have rarely included drug treatment data. This study aimed to examine characteristics of chronic pain and its relation to demographic and health factors, and factors associated with treatment of pain with opioid analgesics. A chronic pain module was added to the 2007 Kansas Behavioral Risk Factor Surveillance System (response rate = 61%). Data on prevalence, duration, frequency, and severity of chronic pain, demographics, and health were collected from a representative sample of 4090 adults 18 years and older by telephone. Logistic regression was used to examine the association of both chronic pain and opioid use with demographic and health factors. Chronic pain was reported by 26.0% of the participants and was associated with activity limitations (adjusted odds ratio [AOR] = 3.6, 95% confidence interval [95% CI] 2.8-4.5), arthritis (AOR = 3.3, 95% CI 2.6-4.0), poor mental health (AOR = 2.0, 95% CI 1.4-2.8), poor overall health (AOR = 1.9; 95% CI 1.5-2.5), and obesity (AOR = 1.6; 95% CI 1.2-2.0). Of the 33.4% of people with pain who use prescription pain medication, 45.7% took opioids, including 36.7% of those with mild pain. Chronic pain affects a quarter of adults in Kansas and is associated with poor health. Opioid analgesics are the mainstay of prescribed pharmacotherapy in this group, even among those reporting mild pain. Published by Elsevier B.V. on behalf of International Association for the Study of Pain. C1 [Toblin, Robin L.; Mack, Karin A.; Paulozzi, Leonard J.] Ctr Dis Control & Prevent, NCIPC, Atlanta, GA 30341 USA. [Toblin, Robin L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Perveen, Ghazala] Bur Hlth Promot, Kansas Dept Hlth & Environm, Topeka, KS 66612 USA. RP Toblin, RL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robin.l.toblin@us.army.mil RI Mack, Karin/A-3263-2012 OI Mack, Karin/0000-0001-9274-3001 FU Centers for Disease Control and Prevention FX The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the US Centers for Disease Control and Prevention or the Kansas Department of Health and Environment. None of the authors has any relevant financial interest in this article. The authors have no conflicts of interest. This work was accomplished entirely using internal funding supplied by the Centers for Disease Control and Prevention. NR 39 TC 60 Z9 62 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD JUN PY 2011 VL 152 IS 6 BP 1249 EP 1255 DI 10.1016/j.pain.2010.12.036 PG 7 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA 765MD UT WOS:000290710100010 PM 21397401 ER PT J AU Pinsker, JE Ondrasik, D Chan, D Fredericks, GJ Tabsola-Nuesca, E Fernandez-Aponte, M Focht, DR Poth, M AF Pinsker, Jordan E. Ondrasik, Deborah Chan, Debora Fredericks, Gregory J. Tabsola-Nuesca, Eludrizza Fernandez-Aponte, Minela Focht, Dean R. Poth, Merrily TI Total and Acylated Ghrelin Levels in Children With Poor Growth SO PEDIATRIC RESEARCH LA English DT Article ID HELICOBACTER-PYLORI INFECTION; SHORT STATURE; HORMONE SECRETAGOGUE; ENDOCRINE; APPETITE; HUMANS; NEUROENDOCRINE; SECRETION; GASTRITIS; OBESITY AB Ghrelin, an enteric hormone with potent appetite stimulating effects, also stimulates growth hormone release. We hypothesized that altered levels of total ghrelin (TG) or acylated ghrelin (AG) could affect growth by altering growth hormone secretion, subsequently affecting insulin-like growth factor-1 (IGF-1) generation or by altering appetite and food intake. After institutional review board approval, 52 children presenting for evaluation of chronic gastrointestinal symptoms (group 1), poor weight gain (group 2), or poor linear growth (group 3) were evaluated for fasting TG and AG levels in addition to their regular evaluation. Serum ghrelin, IGF-1, and prealbumin were compared between groups. No difference was observed for mean fasting TG between groups. However, mean fasting AG was highest in patients in group 2 (465 +/- 128 pg/mL) versus group 1 (176 +/- 37 pg/mL) and group 3 (190 +/- 34 pg/mL). IGF-1 was lowest in patients in group 2 despite similar prealbumin levels among the three groups. We conclude that serum AG levels are highest in children with isolated poor weight gain compared with children with short stature or chronic gastrointestinal symptoms, suggesting the possibility of resistance to AG in underweight children. Additional studies are needed to further clarify ghrelin's role in growth and appetite. (Pediatr Res 69: 517-521, 2011) C1 [Pinsker, Jordan E.; Ondrasik, Deborah; Chan, Debora; Tabsola-Nuesca, Eludrizza; Fernandez-Aponte, Minela] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Fredericks, Gregory J.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Focht, Dean R.] Geisinger Med Ctr, Dept Pediat Gastroenterol, Danville, PA 17822 USA. [Poth, Merrily] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Mail Code MCHK-PE,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 FU Tripler Army Medical Center Department of Clinical Investigation FX Supported by the Tripler Army Medical Center Department of Clinical Investigation. NR 30 TC 4 Z9 4 U1 1 U2 1 PU INT PEDIATRIC RESEARCH FOUNDATION, INC PI BALTIMORE PA 351 W CAMDEN ST, BALTIMORE, MD 21201-2436 USA SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD JUN PY 2011 VL 69 IS 6 BP 517 EP 521 DI 10.1203/PDR.0b013e3182181b2c PG 5 WC Pediatrics SC Pediatrics GA 767CA UT WOS:000290831700009 PM 21386753 ER PT J AU Nayback-Beebe, AM Yoder, LH AF Nayback-Beebe, Ann M. Yoder, Linda H. TI Psychometric Properties of the Interpersonal Relationship Inventory-Short Form for Active Duty Female Service Members SO RESEARCH IN NURSING & HEALTH LA English DT Article DE social support; mental health; women's health; interpersonal relationships; instrument development ID SOCIAL SUPPORT; IPR INVENTORY; RISK-FACTORS; VETERANS; STRESS; DEPLOYMENT; MILITARY; FAMILY; IMPACT; PREVALENCE AB The Interpersonal Relationship Inventory-Short Form (IPRI-SF) has demonstrated psychometric consistency across several demographic and clinical populations; however, it has not been psychometrically tested in a military population. The purpose of this study was to psychometrically evaluate the reliability and component structure of the IPRI-SF in active duty United States Army female service members (FSMs). The reliability estimates were .93 for the social support subscale and .91 for the conflict subscale. Principal component analysis demonstrated an obliquely rotated three-component solution that accounted for 58.9% of the variance. The results of this study support the reliability and validity of the IPRI-SF for use in FSMs; however, a three-factor structure emerged in this sample of FSMs post-deployment that represents "cultural context." (C) 2011 Wiley Periodicals, Inc. Res Nurs Health 34: 241-252, 2011 C1 [Nayback-Beebe, Ann M.] USA, Washington, DC 20301 USA. [Yoder, Linda H.] Univ Texas Austin, Grad Program Nursing Adm & Healthcare Syst Manage, Sch Nursing, Austin, TX 78712 USA. RP Nayback-Beebe, AM (reprint author), 18815 Millhollow, San Antonio, TX 78258 USA. EM ann_nayback@yahoo.com FU TriService Nursing Research Program (TSNRP) [HU 0001-09-1-TS10 (N09-P12)]; Uniformed Services University of the Health Sciences FX Funding for this study was provided by the TriService Nursing Research Program (TSNRP) HU 0001-09-1-TS10 (N09-P12).; This project was sponsored by TriService Nursing Research Program, Uniformed Services University of the Health Sciences; however, the information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Government. NR 44 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0160-6891 J9 RES NURS HEALTH JI Res. Nurs. Health PD JUN PY 2011 VL 34 IS 3 BP 241 EP 252 DI 10.1002/nur.20435 PG 12 WC Nursing SC Nursing GA 762EG UT WOS:000290455000008 PM 21472737 ER PT J AU Berkowitz, JF AF Berkowitz, Jacob F. TI Recent Advances in Wetland Delineation-Implications and impact of Regionalization SO WETLANDS LA English DT Article DE Hydric soils; Hydrophytic vegetation; Wetland boundary; Wetland hydrology AB Methodologies used to identify wetland boundaries continue to evolve and impact ecosystem management. Field testing conducted at 232 locations evaluated Regional Supplements to the 1987 Corps of Engineers Wetlands Delineation Manual. These documents are used for wetland delineation by regulatory agencies and resource managers. Wetland delineations compared 1987 Corps of Engineers Wetland Delineation Manual guidance to Regional Supplement guidance. Supplement testing occurred in 37 States. This document examines changes in the wetland boundary, wetland delineation factors (vegetation, soils, and hydrology), problem situations, and comments provided by field teams. The wetland boundary did not change at 83% (192 sites) of locations. Where the boundary differed, wetland delineation based on Supplement guidance resulted in larger wetland in 12% (28 sites) of cases, while 1987 Manual guidance resulted in a larger wetland in 5% (12 sites) of cases. Changes in the boundary were reported at 25 locations and produced a mean increase of 5.8 m (median 4.6 m). Atypical or problem situations were reported at 22% (51 sites) of the sites examined. Supplement guidance was clear and easily applied at 84% (195 sites) of locations. Teams reported Supplement guidance as more defensible at 79% (183 sites) of locations compared to the 1987 Manual. C1 USA, Corps Engineers, Engn Res & Dev Ctr,CEERD EE W, Environm Lab,Wetlands & Coastal Ecol Branch, Vicksburg, MS 39180 USA. RP Berkowitz, JF (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr,CEERD EE W, Environm Lab,Wetlands & Coastal Ecol Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jacob.F.Berkowitz@usace.army.mil NR 21 TC 1 Z9 1 U1 1 U2 22 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 2011 VL 31 IS 3 BP 593 EP 601 DI 10.1007/s13157-011-0167-6 PG 9 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 765CO UT WOS:000290681200014 ER PT J AU Lichvar, R Gillrich, J Ochs, W AF Lichvar, Robert Gillrich, Jennifer Ochs, Walter TI Discrepancies in Hydrophytic Determinations Produced by Three Vegetation Formulas Used for Wetland Delineations SO WETLANDS LA English DT Article DE Dominance Ratio; Dominants; Prevalence Index; Strata ID GREAT DISMAL SWAMP; BOUNDARY DETERMINATION; WEIGHTED AVERAGES; DOMINANCE; FOREST; SOILS AB We examined disagreement among three methods used in the USA to make hydrophytic vegetation determinations during wetland delineations: the Dominance Ratio (DR), the Prevalence Index (PI), and the FAC-neutral Dominance Ratio (FN-DR). We had two objectives: to determine whether the number of dominant species in a plot affects the percentage of hydrophytic vegetation determinations made by each of the three methods and, if so, to explain the mathematical origin of disagreements among the methods. We compared the percentage of hydrophytic vegetation determinations produced when each method was applied to 200,000 simulations. The PI was the most consistent method for making hydrophytic vegetation determinations. We found that the DR is biased toward nonhydrophytic vegetation when there is an even number of dominant plant species in a plot; it is biased toward hydrophytic vegetation when there is an odd number of dominants. As the number of dominant species and strata increased, there were > 20% more hydrophytic determinations made when we used DR than when we used PI. The FN-DR was also biased; it consistently produced fewer hydrophytic determinations than the other methods. When the DR disagrees with hydric soil and hydrology indicators, delineators should re-examine vegetation using the plot-based PI approach. C1 [Lichvar, Robert; Gillrich, Jennifer] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Lichvar, R (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM robert.w.lichvar@usace.army.mil FU U.S. Army Corps of Engineers FX Peter Gadomski of ERDC/CRREL wrote the code for the vegetation simulations. James Wakeley of ERDC/EL reviewed the manuscript and provided insightful criticism. Stephen Stehman of SUNY-ESF kindly reviewed mathematical characteristics of the PI formula. We also thank two anonymous reviewers for their thoughtful recommendations. Funding for this project was made possible by the Wetlands Regulatory Assistance Program (WRAP) of the U.S. Army Corps of Engineers. NR 19 TC 1 Z9 1 U1 2 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 2011 VL 31 IS 3 BP 603 EP 611 DI 10.1007/s13157-011-0166-7 PG 9 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 765CO UT WOS:000290681200015 ER PT J AU Kumar, A Reddy, ALM Mukherjee, A Dubey, M Zhan, XB Singh, N Ci, L Billups, WE Nagurny, J Mital, G Ajayan, PM AF Kumar, Ashavani Reddy, Arava Leela Mohana Mukherjee, Arnab Dubey, Madan Zhan, Xiaobo Singh, Neelam Ci, Lijie Billups, W. Edward Nagurny, John Mital, Gandhi Ajayan, Pulickel M. TI Direct Synthesis of Lithium-Intercalated Graphene for Electrochemical Energy Storage Application SO ACS NANO LA English DT Article DE graphene; liquid ammonia; lithium intercalation; Li-ion battery ID EXFOLIATED GRAPHITE OXIDE; CARBON NANOTUBES; REDUCTION; INSERTION; ROUTE; NANOPLATELETS; DISSOLUTION; NITROGEN AB A novel approach for bulk synthesis of lithium-intercalated graphene sheets through the reduction of exfoliated graphene oxide in liquid ammonia and lithium metal Is reported. It is demonstrated here that as-synthesized lithlated graphite oxide sheets (Li-RGO) can be directly used as an electrode material in lithium batteries. The electrochemical studies on Li-RGO electrodes show a significant enhancement in the specific capacity of the lithium battery over commercially available graphite electrodes. Partial intercalation of lithium ions in between graphene layers makes this material a good candidate for electrochemical energy storage applications. C1 [Kumar, Ashavani; Reddy, Arava Leela Mohana; Zhan, Xiaobo; Singh, Neelam; Ci, Lijie; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Mukherjee, Arnab; Billups, W. Edward; Ajayan, Pulickel M.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. [Nagurny, John; Mital, Gandhi] Lockheed Martin Maritime Syst & Sensors, Manassas, VA 20110 USA. RP Reddy, ALM (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, 6100 Main St, Houston, TX 77005 USA. EM leela@rice.edu; ajayan@rice.edu RI 慈, 立杰/E-3485-2014; Arava, Leela Mohana Reddy/J-3180-2015 FU Welch Foundation [C-0490]; Army Research Office FX Financial support from Lockheed Martin is acknowledged. W.E.B. is supported by the Welch Foundation (C-0490). A.L.M.R. thanks the Army Research Office for funding support. NR 35 TC 72 Z9 73 U1 4 U2 79 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD JUN PY 2011 VL 5 IS 6 BP 4345 EP 4349 DI 10.1021/nn201527p PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 783AZ UT WOS:000292055200014 PM 21609023 ER PT J AU Biddle, TD AF Biddle, Tami Davis TI Media, Memory, and the First World War SO AMERICAN HISTORICAL REVIEW LA English DT Book Review C1 [Biddle, Tami Davis] USA, War Coll, Washington, DC USA. RP Biddle, TD (reprint author), USA, War Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD JUN PY 2011 VL 116 IS 3 BP 763 EP 764 PG 2 WC History SC History GA 784RO UT WOS:000292176100019 ER PT J AU Helfer, TM Jordan, NN Lee, RB Pietrusiak, P Cave, K Schairer, K AF Helfer, Thomas M. Jordan, Nikki N. Lee, Robyn B. Pietrusiak, Paul Cave, Kara Schairer, Kim TI Noise-Induced Hearing Injury and Comorbidities Among Postdeployment U.S. Army Soldiers: April 2003-June 2009 SO AMERICAN JOURNAL OF AUDIOLOGY LA English DT Article DE noise-induced hearing injury; mild traumatic brain injury; posttraumatic stress disorder; blast trauma; speech-language disorders ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; LOSS PREVENTION PROGRAMS; BLAST; IRAQ; POPULATIONS; UPDATE; TEAM; DUTY; EAR AB Purpose: To evaluate noise-induced hearing injury (NIHI) and blast-related comorbidities among U.S. Army soldiers in an effort to understand the morbidity burden and future health service requirements for wounded war fighters returning from the Central Command Area of Responsibility, predominantly from Iraq and Afghanistan deployments. Method: Inpatient and outpatient records with diagnosed NIHI or blast-related comorbidities (e.g., significant threshold shift [STS], noise-induced hearing loss, tinnitus, sensorineural hearing loss, eardrum perforations, mild traumatic brain injury, and posttraumatic stress disorder) were extracted for active duty soldiers returning from combat deployments. Records were limited to those within 6 months of the soldier's return date from April 2003 through June 2009. To account for changes in STS coding practice, STS rates observed after October 1, 2006, were used to extrapolate prior probable postdeployment STS. Results: Statistically significant increases were observed for tinnitus, dizziness, eardrum perforations, and speech-language disorders. The combination of observed and extrapolated STS yielded a conservative estimate of 27,427 cases. Conclusions: Estimates can be used to forecast resource requirements for hearing services among veterans. This article could serve as a guide for resourcing and innovating prevention measures and treatment in this population. Data provided may also serve as a baseline for evaluating prevention measures. C1 [Helfer, Thomas M.; Jordan, Nikki N.; Lee, Robyn B.; Pietrusiak, Paul] USA, Publ Hlth Command Provis, Inst Publ Hlth, Gunpowder, MD USA. [Cave, Kara] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Schairer, Kim] Univ Wisconsin, Madison, WI 53706 USA. RP Helfer, TM (reprint author), USA, Publ Hlth Command Provis, Inst Publ Hlth, Gunpowder, MD USA. EM thomas.helfer@us.army.mil RI Schueter, nicos/A-3625-2014 NR 53 TC 14 Z9 16 U1 0 U2 5 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1059-0889 J9 AM J AUDIOL JI Am. J. Audiol. PD JUN PY 2011 VL 20 IS 1 BP 33 EP 41 DI 10.1044/1059-0889(2011/10-0033) PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 782IP UT WOS:000292002000005 PM 21474555 ER PT J AU Porter, KL Olmstead, AW Kumsher, DM Dennis, WE Sprando, RL Holcombe, GW Korte, JJ Lindberg-Livingston, A Degitz, SJ AF Porter, Karen L. Olmstead, Allen W. Kumsher, David M. Dennis, William E. Sprando, Robert L. Holcombe, Gary W. Korte, Joseph J. Lindberg-Livingston, Annelie Degitz, Sigmund J. TI Effects of 4-tert-octylphenol on Xenopus tropicalis in a long term exposure SO AQUATIC TOXICOLOGY LA English DT Article DE Xenopus tropicalis; Octylphenol; Estrogenic; Vitellogenin; Oviducts ID CHROMATOGRAPHY-MASS SPECTROMETRY; MEDAKA ORYZIAS-LATIPES; FROG RANA-PIPIENS; ENDOCRINE DISRUPTION; BISPHENOL-A; IN-VITRO; ESTROGENIC ACTIVITY; REPRODUCTIVE TOXICITY; SEX-DIFFERENTIATION; POLYCHLORINATED-BIPHENYLS AB Endocrine disrupting chemicals that activate the estrogen receptor are routinely detected in the environment and are a concern for the health of both exposed humans and indigenous wildlife. We exposed the western clawed frog (Xenopus tropicalis) to the weak estrogen octylphenol from Nieuwkoop-Faber (NF) stage 46 tadpoles through adulthood in order to document the effects of a weak estrogen on the life history of an amphibian species. Frogs were exposed to 1, 3.3, 11 and 36 mu g/L octylphenol in a continuous flow-through water system. Just prior to completion of metamorphosis (NF 65), a random subsample of froglets was collected and assessed, while the remaining frogs received continued exposure through 31 weeks of exposure when the remaining animals were sampled. Significant induction of the female egg yolk protein precursor vitellogenin was observed in the high treatment at the larval subsampling for both males and females, but not at the final sampling for either sex. No significant deviation from the control sex ratio was observed for either sampling period, suggesting minimal to no effect of octylphenol exposure on gonad differentiation. No effects in the adult frogs were observed for mortality, body mass and size, liver somatic index, estradiol and testosterone serum levels, sperm counts, or oocyte counts. The development and growth of oviducts, a female-specific secondary sex characteristic, was observed in males exposed to octyl phenol. These results indicate that octylphenol exposure can induce vitellogenin in immature froglets and the development of oviducts in male adult frogs. The lack of effect observed on the developing gonads suggests that in amphibians, secondary sex characteristics are more susceptible to impact from estrogenic compounds than the developing gonads. Published by Elsevier B.V. C1 [Porter, Karen L.; Kumsher, David M.; Dennis, William E.] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [Olmstead, Allen W.; Holcombe, Gary W.; Korte, Joseph J.; Lindberg-Livingston, Annelie; Degitz, Sigmund J.] US EPA, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA. [Sprando, Robert L.] US FDA, Ctr Food Safety & Appl Nutr, Div Toxicol, Laurel, MD USA. RP Porter, KL (reprint author), USA, Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM karen.porter@amedd.army.mil NR 70 TC 12 Z9 13 U1 6 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X J9 AQUAT TOXICOL JI Aquat. Toxicol. PD JUN PY 2011 VL 103 IS 3-4 BP 159 EP 169 DI 10.1016/j.aquatox.2011.02.019 PG 11 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA 781CL UT WOS:000291908100004 PM 21470552 ER PT J AU Skolness, SY Durhan, EJ Garcia-Reyero, N Jensen, KM Kahl, MD Makynen, EA Martinovic-Weigelt, D Perkins, E Villeneuve, DL Ankley, GT AF Skolness, Sarah Y. Durhan, Elizabeth J. Garcia-Reyero, Natalia Jensen, Kathleen M. Kahl, Michael D. Makynen, Elizabeth A. Martinovic-Weigelt, Dalma Perkins, Edward Villeneuve, Daniel L. Ankley, Gerald T. TI Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas) SO AQUATIC TOXICOLOGY LA English DT Article DE Estrogen; Fish; Microarray; Vitellogenin; Endocrine disruption; Aromatase ID ACTIVITY IN-VITRO; AROMATASE-ACTIVITY; BINDING-PROTEIN; MESSENGER-RNA; TRIAZOLE ANTIFUNGALS; STEROIDOGENESIS; INHIBITION; KETOCONAZOLE; REPRODUCTION; PESTICIDES AB Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic-pituitary-gonadal (HPG) axis. To determine the short-term impacts of prochloraz on gene expression and steroid production, adult female fathead minnows (Pimephales promelas) were exposed to the chemical (0 or 300 mu g/L) for a time-course of 6, 12 and 24 h. Consistent with inhibition of cytochrome P450 17 alpha-hydroxylase/17,20-lyase (CYP17) and aromatase (CYP19), known molecular targets of prochloraz, plasma 17 beta-estradiol (E2) was reduced within 6h. Ex vivo E2 production was significantly reduced at all time-points, while ex vivo testosterone (T) production remained unchanged. Consistent with the decrease in E2 levels, plasma concentrations of the estrogen-responsive protein vitellogenin were significantly reduced at 24h. Genes coding for CYP19. CYP17, and steroidogenic acute regulatory protein were up-regulated in a compensatory manner in ovaries of the prochloraz-treated fish. In addition to targeted quantitative real-time polymerase chain reaction analyses, a 15k feature fathead minnow microarray was used to determine gene expression profiles in ovaries. From time-point to time-point, the microarray results showed a relatively rapid change in the differentially expressed gene (DEG) profiles associated with the chemical exposure. Functional analysis of the DEGs indicated changes in expression of genes associated with cofactor and coenzyme binding (GO:0048037 and 0050662), fatty acid binding (GO:0005504) and organelle organization and biogenesis (GO:0006996). Overall, the results from this study are consistent with compensation of the fish HPG axis to inhibition of steroidogenesis by prochloraz, and provide further insights into relatively rapid, system-wide, effects of a model chemical stressor on fish. (C) 2011 Elsevier B.V. All rights reserved. C1 [Skolness, Sarah Y.; Durhan, Elizabeth J.; Jensen, Kathleen M.; Kahl, Michael D.; Makynen, Elizabeth A.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Skolness, Sarah Y.] Univ Minnesota, Dept Biochem & Mol Biol, Duluth, MN 55812 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Martinovic-Weigelt, Dalma] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. [Perkins, Edward] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Skolness, SY (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Skolness.sarah@epa.gov OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU US Environmental Protection Agency (USEPA); University of Minnesota-Duluth FX We thank Jenna Cavallin and Nathan Mueller who provided valuable technical assistance for the work and Dr. Michael Hornung for the helpful comments on an earlier version of this article. SYS was supported through Cooperative Agreement between the US Environmental Protection Agency (USEPA) and the University of Minnesota-Duluth. This article had been reviewed in accordance with USEPA policy. Mention of specific products does not indicate endorsement by USEPA. NR 49 TC 30 Z9 34 U1 3 U2 35 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X J9 AQUAT TOXICOL JI Aquat. Toxicol. PD JUN PY 2011 VL 103 IS 3-4 BP 170 EP 178 DI 10.1016/j.aquatox.2011.02.016 PG 9 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA 781CL UT WOS:000291908100005 PM 21470553 ER PT J AU Hart, SD AF Hart, Steven D. TI On Populations and Power Sources SO CIVIL ENGINEERING LA English DT Letter C1 US Mil Acad, West Point, NY 10996 USA. RP Hart, SD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD JUN PY 2011 VL 81 IS 6 BP 8 EP 8 PG 1 WC Engineering, Civil SC Engineering GA 783DZ UT WOS:000292063000002 ER PT J AU Zoraster, RM AF Zoraster, Richard M. TI Working With Interpreters During International Health Responses SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE disaster; language; interpreter; translator; communication ID OF-THE-LITERATURE; LANGUAGE BARRIERS; MEDICAL INTERPRETERS; HAITIAN EARTHQUAKE; CULTURAL COMPETENCE; FAMILY INTERPRETERS; CARE; COMMUNICATION; ROLES; ENCOUNTERS AB Health care providers face multiple difficulties in providing care to a disaster-stricken community. Training, preparation, and a good attitude are important, as is adequate logistical support. An often-ignored issue is the difficulty encountered with language barriers during a response, and how using interpreters affects the quality and impact of the health care provided. This article reviews the use of interpreters and focuses on how they may affect an international health care response. (Disaster Med Public Health Preparedness. 2011; 5: 159-163) C1 [Zoraster, Richard M.] Tripler Army Med Ctr, Ctr Excellence Disaster Management & Humanitarian, Honolulu, HI 96859 USA. RP Zoraster, RM (reprint author), Tripler Army Med Ctr, Ctr Excellence Disaster Management & Humanitarian, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM richard.zoraster@coe-dmha.org NR 59 TC 0 Z9 0 U1 4 U2 15 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD JUN PY 2011 VL 5 IS 2 BP 159 EP 163 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 778SL UT WOS:000291725800013 PM 21685310 ER PT J AU Bastian, ND AF Bastian, Nathaniel D. TI Optimizing Army Sustainability at Fort Bragg: A Case Study Connecting Life-Cycle Cost Analysis with Leadership in Energy and Environmental Design for Existing Buildings SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Engineering Economics; Sustainability; Life-Cycle Cost Analysis; Optimization; Monte Carlo Simulation; Decision-Making AB In 2006, the Assistant Secretary of the Army for Installations and Environment announced the Army's desire to transition to the U.S. Green Building Council's Leadership in Energy and Environmental Design for Existing Buildings rating scheme in an effort to institutionalize sustainable practices across all Army facilities. This article describes an engineering management tool developed for project managers at Fort Bragg's Directorate of Housing and Public Works used to determine the most cost-effective route to building certification and to support the Army goal of sustainability. The results expose practicing engineering managers to a significant issue concerning Army sustainability, where numerous engineering management methods are employed for more effective decision-making. Future research is needed to convert retrofit project life-cycle costs from specific location sources to national values. C1 USA, Wheeler Army Airfield, HI USA. RP Bastian, ND (reprint author), USA, 3-25th Aviat Regiment, Wheeler Army Airfield, HI USA. EM nathaniel.bastian@fulbrightmail.org NR 20 TC 4 Z9 4 U1 0 U2 9 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD JUN PY 2011 VL 23 IS 2 BP 42 EP 54 PG 13 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 971JG UT WOS:000306199600005 ER PT J AU Julian, C Lucy, T Farr, J AF Julian, Cotye Lucy, Tana Farr, John TI Commercial-Off-The-Shelf Selection Process SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Commercial-Off-The-Shelf; COTS; Technology Insertion; Technology Evaluation; Technology Management AB This article presents a Commercial-Off-The-Shelf (COTS) evaluation and selection process that utilizes a weighted scoring model to facilitate the comparison of COTS components relative to a number of pre-established evaluation criteria. The application of a COTS evaluation methodology will enable project teams responsible for designing complex systems to take advantage of potential economic leverage and performance advantages COTS technology presents. More importantly, this approach provides a mechanism for careful evaluation of the candidate COTS components to ensure engineers developing COTS-intensive systems give appropriate consideration to critical COTS attributes such as operational requirements, risk, cost, technology maturity, and supplier viability. C1 [Farr, John] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Lucy, Tana] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Julian, Cotye] Sandia Natl Labs, Albuquerque, NM USA. RP Farr, J (reprint author), US Mil Acad, Dept Syst Engn, Rm 403A,MaHan Hall, West Point, NY 10996 USA. EM john.farr@usma.edu NR 10 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD JUN PY 2011 VL 23 IS 2 BP 63 EP 71 PG 9 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 971JG UT WOS:000306199600007 ER PT J AU Thomas, SJ Endy, TP AF Thomas, Stephen J. Endy, Timothy P. TI Vaccines for the prevention of dengue Development update SO HUMAN VACCINES LA English DT Review DE dengue; vaccine; development; pre-clinical; clinical ID VIRUS-NEUTRALIZING ANTIBODIES; ENVELOPE DOMAIN-III; RECOMBINANT FUSION PROTEIN; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; T-CELL RESPONSES; ATTENUATED DENGUE; YELLOW-FEVER; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES AB The dengue viruses (DENV) are mosquito-borne flaviviruses which cause a spectrum of clinical disease known as "dengue," and have emerged and re-emerged as a significant global health problem. It is estimated more than 120 countries currently have endemic DENV transmission, 55% of the world's population is at risk of infection, and there are between 70-500 million infections of which 2.1 million are clinically severe resulting in more than 21,000 deaths annually. By all estimates the global dengue problem will continue to worsen due to the increasing mobility of the population, ecological changes and the inability to effectively sustain vector control. There are no licensed antivirals or vaccines to treat or prevent dengue. The development and widespread use of safe and efficacious dengue vaccine is required to significantly reduce the global dengue burden. In this review the authors discuss dengue vaccines currently in the pre-clinical and clinical development pipeline. C1 [Thomas, Stephen J.] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. SUNY Syracuse, Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY USA. RP Thomas, SJ (reprint author), US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. EM stephen.thomas@afrims.org NR 196 TC 29 Z9 30 U1 2 U2 8 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD JUN PY 2011 VL 7 IS 6 BP 674 EP 684 DI 10.4161/hv.7.6.14985 PG 11 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 785RQ UT WOS:000292247000020 PM 21508679 ER PT J AU Bradfute, SB Dye, JM Bavari, S AF Bradfute, Steven B. Dye, John M. Bavari, Sina TI Filovirus vaccines SO HUMAN VACCINES LA English DT Review DE ebola; ebola virus; ebolavirus; filovirid; filoviridae; filovirus; marburg virus; marburgvirus; mononegavirad; mononegavirales; mononegavirus; vaccine ID EBOLA-VIRUS-INFECTION; EQUINE ENCEPHALITIS-VIRUS; PROTECT GUINEA-PIGS; ATTENUATED RECOMBINANT VACCINE; MARBURG HEMORRHAGIC-FEVER; T-CELL RESPONSES; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; PARTICLES PROTECT; DENDRITIC CELLS AB Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed. C1 [Bradfute, Steven B.; Dye, John M.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Natl Interagency Biodef Campus, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil FU Department of Defense through the Defense Threat Reduction Agency (DTRA) [1.1C0003_08_RD_B]; US Department of Energy; US Army Medical Research and Materiel Command FX We thank Jens Kuhn, Amy Shurtleff and Gordon Ruthel for critical review of the manuscript. This work was supported in part by the Joint Science and Technology Office program project number 1.1C0003_08_RD_B from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA) (S. B.); and in part by an appointment to the Postgraduate Research Participation Program at the US Army Medical Research Institute for Infectious Disease administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and US Army Medical Research and Materiel Command (S. B.B.). NR 95 TC 18 Z9 20 U1 1 U2 8 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD JUN PY 2011 VL 7 IS 6 BP 701 EP 711 DI 10.4161/hv.7.6.15398 PG 11 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 785RQ UT WOS:000292247000023 PM 21519188 ER PT J AU Montgomery, VA Smith, LA AF Montgomery, Vicki A. Smith, Leonard A. TI Diagnostic and Possible Therapeutic Application of a Monoclonal Antibody (14G8) Directed Against botulinum Type C Neurotoxin SO HYBRIDOMA LA English DT Article ID POLYMERASE-CHAIN-REACTION; CLOSTRIDIUM-BOTULINUM; ENVIRONMENTAL-SAMPLES; BINDING DOMAIN; AVIAN BOTULISM; D STRAINS; TOXINS; PCR; RELEASE; CELLS AB A monoclonal antibody, designated 14G8, detected Clostridium botulinum type C neurotoxin in immunoassays requiring native confirmation of the analyte. 14G8 bound to the light chain of the type C neurotoxin, which is conserved between strains of C. botulinum type C and C/d mosaic neurotoxins. 14G8 did not react to any other serotypes of C. botulinum neurotoxins. In mouse phrenic nerve-hemidiaphragm assays, 14G8, when combined with a second antibody (5D9-H9-A9, which reacts to epitopes on the carboxy terminus of the heavy chain), was able to protect the mouse myoneural junction from intoxication with C. botulinum type C neurotoxin. When used individually, both 14G8 and 5D9-H9-G9 antibodies slowed the loss of twitch tension in the mouse phrenic nerve-hemidiaphragm assays, but did not completely protect the phrenic nerve from paralysis. In in vivo mouse botulinum neurotoxin type C challenge studies, the combination of 14G8 and 5D9-H9-A9 significantly increased mean time-to-death and survival when compared to toxin controls and mice receiving only one of the monoclonal antibodies. These results suggest that the 14G8 monoclonal antibody could have useful therapeutic applications. C1 [Montgomery, Vicki A.] USA, Res Inst Infect Dis, Div Integrated Toxicol, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Montgomery, VA (reprint author), USA, Res Inst Infect Dis, Div Integrated Toxicol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM vicki.montgomery@amedd.army.mil FU Joint Science and Technology Office for Chemical Biological Defense, Defense Threat Reduction Agency FX The authors declare no conflict of interest in the publication of this manuscript. This work was sponsored by The Joint Science and Technology Office for Chemical Biological Defense, Defense Threat Reduction Agency. The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense. NR 28 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1554-0014 J9 HYBRIDOMA JI Hybridoma PD JUN PY 2011 VL 30 IS 3 BP 209 EP 216 DI 10.1089/hyb.2010.0109 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA 784ED UT WOS:000292137000001 PM 21707354 ER PT J AU Montgomery, VA AF Montgomery, Vicki A. TI Monoclonal Antibody 5D9-H9-A9 Anti-Botulinum Neurotoxin Type C SO HYBRIDOMA LA English DT Article C1 USA, Med Res Inst Infect Dis, Div Integrated Toxicol, Frederick, MD 21702 USA. RP Montgomery, VA (reprint author), USA, Med Res Inst Infect Dis, Div Integrated Toxicol, 1425 Porter St, Frederick, MD 21702 USA. EM vicki.montgomery@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1554-0014 J9 HYBRIDOMA JI Hybridoma PD JUN PY 2011 VL 30 IS 3 BP 311 EP 311 DI 10.1089/hyb.2010.0118.MAb PG 1 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA 784ED UT WOS:000292137000016 ER PT J AU Montgomery, VA AF Montgomery, Vicki A. TI Monoclonal Antibody 14G8 Anti-Botulinum Neurotoxin Type C SO HYBRIDOMA LA English DT Article C1 USA, Med Res Inst Infect Dis, Div Integrated Toxicol, Frederick, MD 21702 USA. RP Montgomery, VA (reprint author), USA, Med Res Inst Infect Dis, Div Integrated Toxicol, 1425 Porter St, Frederick, MD 21702 USA. EM vicki.montgomery@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1554-0014 J9 HYBRIDOMA JI Hybridoma PD JUN PY 2011 VL 30 IS 3 BP 312 EP 312 DI 10.1089/hyb.2010.0119.MAb PG 1 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA 784ED UT WOS:000292137000017 ER PT J AU Owens, FJ Gladczuk, L Szymczak, R Dluzewski, P Wisniewski, A Szymczak, H Golnik, A Bernhard, C Niedermayer, C AF Owens, Frank J. Gladczuk, L. Szymczak, R. Dluzewski, P. Wisniewski, A. Szymczak, H. Golnik, A. Bernhard, Ch. Niedermayer, Ch. TI High temperature magnetic order in zinc sulfide doped with copper SO JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS LA English DT Article DE Semiconductors; Magnetic properties; muon spin resonance (mu SR) ID ROOM-TEMPERATURE; MICROWAVE-ABSORPTION; THIN-FILMS; FERROMAGNETISM; SEMICONDUCTORS; STATES; BULK; ZNO AB We report the first observation of magnetic order above room temperature in zinc sulfide doped with Cu2+ made by a simple sintering process and detected by ferromagnetic resonance (FMR), SQUID magnetometry and the mu SR experiments. FMR study shows nonzero absorption above room temperature indicating a high value of Curie temperature. Field-cooled and zero-field-cooled magnetization data indicate a bifurcation at about 300 K. This temperature is considered to be the blocking temperature at ferromagnetic nanosized regions, which appear to exist in the sample of ZnS doped with copper. The muon spin rotation measurements confirm highly nonuniform magnetic order. It was shown that about 25% of the sample volume fraction exhibits strong magnetism. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Gladczuk, L.; Szymczak, R.; Dluzewski, P.; Wisniewski, A.; Szymczak, H.] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland. [Owens, Frank J.] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Owens, Frank J.] CUNY Hunter Coll, Dept Phys, New York, NY 10024 USA. [Golnik, A.] Univ Warsaw, Inst Expt Phys, PL-00681 Warsaw, Poland. [Bernhard, Ch.] Univ Fribourg, Dept Phys, CH-1700 Fribourg, Switzerland. [Bernhard, Ch.] Univ Fribourg, FriMat Ctr Nanomat, CH-1700 Fribourg, Switzerland. [Niedermayer, Ch.] Swiss Fed Inst Technol, Neutron Scattering Lab, CH-5232 Villigen, Switzerland. [Niedermayer, Ch.] Paul Scherrer Inst, CH-5232 Villigen, Switzerland. RP Gladczuk, L (reprint author), Polish Acad Sci, Inst Phys, Aleja Lotnikow 32-46, PL-02668 Warsaw, Poland. EM gladl@ifpan.edu.pl RI Dluzewski, Piotr/A-3289-2012; Niedermayer, Christof/K-4436-2014; Wisniewski, Andrzej/A-1781-2017 OI Dluzewski, Piotr/0000-0002-4153-6309; FU Schweizer Nationalfonds (SNF) [200020-119784]; EU [MTKD-CT-2005-029671] FX The OR experiments were performed at the Swiss Muon Source, Paul Scherrer Institute, Villigen, Switzerland. The authors are grateful to Prof. W. Paszkowicz for assistance in X-ray diffraction measurements. CB acknowledges support by the Schweizer Nationalfonds (SNF) in Grant 200020-119784 and AG-partial support by the MTKD-CT-2005-029671 project from the EU. NR 25 TC 15 Z9 16 U1 0 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3697 EI 1879-2553 J9 J PHYS CHEM SOLIDS JI J. Phys. Chem. Solids PD JUN PY 2011 VL 72 IS 6 BP 648 EP 652 DI 10.1016/j.jpcs.2011.02.009 PG 5 WC Chemistry, Multidisciplinary; Physics, Condensed Matter SC Chemistry; Physics GA 781FF UT WOS:000291915300008 ER PT J AU Mendenhall, IH Giraldo-Calderon, GI Ocampo, CD Wesson, DM Pecor, JE AF Mendenhall, Ian H. Giraldo-Calderon, Gloria I. Ocampo, Clara D. Wesson, Dawn M. Pecor, James E. TI FIRST RECORD OF CULEX (ANOEDIOPORPA) RESTRICTOR FROM COLOMBIA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Editorial Material DE Culex restrictor; Colombia AB We report the first record of Culex (Anoedioporpa) restrictor collected from a tree hole in the Cauca Valley, Colombia, in 2006. C1 [Mendenhall, Ian H.; Wesson, Dawn M.] Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA. [Giraldo-Calderon, Gloria I.; Ocampo, Clara D.] Ctr Int Entrenamiento & Invest Med, Cali, Colombia. [Pecor, James E.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Mendenhall, IH (reprint author), Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA. NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2011 VL 27 IS 2 BP 148 EP 148 DI 10.2987/10-6102.1 PG 1 WC Entomology SC Entomology GA 973FH UT WOS:000306343700009 PM 21805847 ER PT J AU McGehee, E Isaacson, J AF McGehee, Ellen Isaacson, John TI Interpreting the Bomb Contested History and the Proposed Manhattan Project National Historical Park at Los Alamos SO JOURNAL OF THE WEST LA English DT Article C1 [McGehee, Ellen; Isaacson, John] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Isaacson, John] Univ Illinois, Mat Res Lab, Ancient Technol & Archeol Mat Program, Chicago, IL 60680 USA. [Isaacson, John] Harvard Univ, Gordon McKay Mat Res Lab, Cambridge, MA 02138 USA. [Isaacson, John] USA, Spatial Anal & Syst Team, Construct Engn Res Lab, Champaign, IL USA. [Isaacson, John] USA, Cultural Resources Res Ctr, Construct Engn Res Lab, Champaign, IL USA. RP McGehee, E (reprint author), Los Alamos Natl Lab, Los Alamos, NM 87545 USA. NR 36 TC 0 Z9 0 U1 1 U2 1 PU ABC-CLIO PI SANTA BARBARA PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA SN 0022-5169 J9 J WEST JI J. West PD SUM PY 2011 VL 50 IS 3 BP 51 EP 61 PG 11 WC History SC History GA 994FL UT WOS:000307916200007 ER PT J AU Bandara, S Maloney, P Baril, N Pellegrino, J Tidrow, M AF Bandara, Sumith Maloney, Patrick Baril, Neil Pellegrino, Joseph Tidrow, Meimei TI Doping dependence of minority carrier lifetime in long-wave Sb-based type II superlattice infrared detector materials SO OPTICAL ENGINEERING LA English DT Article DE infrared detectors; strained layer superlattices; minority carrier lifetime ID PERFORMANCE AB Theoretical modeling and experimental evidence show that the dark currents of antimonide (Sb)-based Type-II Superlattice (T2SL) detectors sensitive to long-wavelength infrared (LWIR) radiation are limited by the minority carrier lifetimes associated with the Shockley Read-Hall (SRH) generation-recombination process. Despite the low minority carrier lifetimes, the present photodiode dark current performance is achieved by increasing the background doping density of the absorber layers to N-A similar to 2 x 10(16) cm(-3). This paper will discuss the measured minority carrier lifetimes of T2SL LWIR detectors with various background doping densities. To make comparisons, we designed several T2SL absorber layers sensitive in the LWIR range and p-type doped up to various densities. We find the minority carrier lifetimes are dominated by the SRH generation-recombination process. By analyzing minority carrier lifetime data as a function of excess carrier densities, we estimate SRH lifetimes and actual ionized acceptor densities of the absorber layers. The data are compared with the measured impurity doping densities of the detectors. In addition, we predict the type of flaws responsible for the SRH recombination process and narrow down the flaw energy level relative to the Fermi energy. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3590720] C1 [Bandara, Sumith; Maloney, Patrick; Baril, Neil; Pellegrino, Joseph; Tidrow, Meimei] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Bandara, S (reprint author), USA, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM sumith.bandara@us.army.mil NR 14 TC 12 Z9 12 U1 0 U2 14 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUN PY 2011 VL 50 IS 6 AR 061015 DI 10.1117/1.3590720 PG 5 WC Optics SC Optics GA 786IU UT WOS:000292299400014 ER PT J AU Choi, KK Jhabvala, MD Forrai, D Sun, J Endres, D AF Choi, Kwong-Kit Jhabvala, Murzy D. Forrai, David Sun, Jason Endres, Darrel TI Corrugated quantum well infrared photodetectors for far infrared detection SO OPTICAL ENGINEERING LA English DT Article DE quantum well infrared photodetector; focal plane array; noise equivalent temperature difference AB We have extended our investigation of corrugated quantum well infrared photodetector focal plane arrays (FPAs) into the far infrared regime. Specifically, we are developing the detectors for the thermal infrared sensor (TIRS) used in the Landsat Data Continuity Mission. To maintain a low dark current, we adopted a low doping density of 0.6 x 10(18) cm(-3) and a bound-to-bound state detector. The internal absorption quantum efficiency (QE) is calculated to be 25.4%. With a pixel fill factor of 80% and a substrate transmission of 70.9%, the external QE is 14.4%. To yield the theoretical conversion efficiency (CE), the photoconductive gain was measured and is 0.25 at 5 V, from which CE is predicted to be 3.6%. This value is in agreement with the 3.5% from the FPA measurement. Meanwhile, the dark current is measured to be 2.1 x 10(-6) A/cm(2) at 43 K. For regular infrared imaging above 8 mu m, the FPA will have an noise equivalent temperature difference (NETD) of 16 mK at 2 ms integration time in the presence of 260 read noise electrons. The highest operability of the tested FPAs is 99.967%. With the CE agreement, we project the FPA performance in the far infrared regime up to 30 mu m cutoff. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3578406] C1 [Choi, Kwong-Kit; Sun, Jason] USA, Res Lab, Adelphi, MD 20783 USA. [Jhabvala, Murzy D.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Forrai, David; Endres, Darrel] L3 Cincinnati Elect, Mason, OH 45040 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kwongkit.choi@us.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 5 TC 1 Z9 1 U1 0 U2 11 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUN PY 2011 VL 50 IS 6 AR 061005 DI 10.1117/1.3578406 PG 6 WC Optics SC Optics GA 786IU UT WOS:000292299400005 ER PT J AU Klemcke, HG Joe, B Calderon, ML Rose, R Oh, T Aden, J Ryan, KL AF Klemcke, Harold G. Joe, Bina Calderon, Mariam L. Rose, Rajiv Oh, Thomas Aden, James Ryan, Kathy L. TI Genetic influences on survival time after severe hemorrhage in inbred rat strains SO PHYSIOLOGICAL GENOMICS LA English DT Article DE inbred rats; quantitative trait; blood volume; epigenetic ID TOTAL BLOOD VOLUME; PLASMA VOLUME; CELL VOLUME; EVANS BLUE; ISOFLURANE; MORTALITY; ISCHEMIA; TRAUMA; SHOCK; CARDIOPROTECTION AB Klemcke HG, Joe B, Calderon ML, Rose R, Oh T, Aden J, Ryan KL. Genetic influences on survival time after severe hemorrhage in inbred rat strains. Physiol Genomics 43: 758-765, 2011. First published April 12, 2011; doi:10.1152/physiolgenomics.00245.2010.-To find a genetic basis for differential ability to survive severe hemorrhage, we previously showed eightfold differences in survival times among inbred rat strains. We assumed that rat strains had similar normalized blood volumes (NBV; ml/100 g body wt). As NBV might vary among strains and constitute one genetic variable affecting survival time to hemorrhage, in experiment 1 of the current studies we first measured total blood volumes and calculated NBV in specific inbred rat strains (Brown Norway/Medical College of Wisconsin, BN; Dark Agouti, DA; Fawn Hooded Hypertensive, FHH; Lewis, LEW; and Dahl Salt-Sensitive, SS) previously found to be divergent in survival time. NBV differed by 20% (P < 0.01; BN > SS > FHH = LEW = DA) and had a heritability (h(2)) of 0.56. Hence, differential survival times in our previously published study might reflect strain-dependent differences in NBV. Then studies were conducted wherein rats were catheterized and, similar to 24 h later, 47% of their blood volume was removed; these rats were observed for a maximum of 4 h. In experiment 2, blood volumes were measured the day prior to hemorrhage. Percent survival and survival time did not differ among strains. To obviate possible confounding effects of blood volume determination, in experiment 3 the average NBV for each strain was used to determine hemorrhage volumes. Percent survival (P < 0.01) and survival times (P < 0.001) were different with DA demonstrating the best (62.5%, 190 +/- 29 min) and BN the worst (0%, 52 +/- 5 min) survival responses. These data indicate that both blood volume and survival time after hemorrhage in rats are heritable quantitative traits, and continue to suggest that genetic assessment of these phenotypes might lead to novel therapeutics to improve survival to hemorrhage. C1 [Klemcke, Harold G.; Calderon, Mariam L.; Rose, Rajiv; Oh, Thomas; Aden, James; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Joe, Bina] Univ Toledo, Dept Physiol & Pharmacol, Coll Med, Physiol Genom Lab, Toledo, OH 43606 USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil NR 45 TC 6 Z9 7 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1094-8341 EI 1531-2267 J9 PHYSIOL GENOMICS JI Physiol. Genomics PD JUN PY 2011 VL 43 IS 12 BP 758 EP 765 DI 10.1152/physiolgenomics.00245.2010 PG 8 WC Cell Biology; Genetics & Heredity; Physiology SC Cell Biology; Genetics & Heredity; Physiology GA 784DX UT WOS:000292136200005 PM 21487033 ER PT J AU Weiland, MA Deng, ZD Seim, TA LaMarche, BL Choi, EY Fu, T Carlson, TJ Thronas, AI Eppard, MB AF Weiland, Mark A. Deng, Z. Daniel Seim, Tom A. LaMarche, Brian L. Choi, Eric Y. Fu, Tao Carlson, Thomas J. Thronas, Aaron I. Eppard, M. Brad TI A Cabled Acoustic Telemetry System for Detecting and Tracking Juvenile Salmon: Part 1. Engineering Design and Instrumentation SO SENSORS LA English DT Article DE acoustic telemetry; microtransmitter; juvenile salmon ID HYDROPHONE ARRAY; CHINOOK SALMON; PASSAGE; LOCATION; TURBINES; TRANSMITTERS; LOCALIZATION; PERFORMANCE; ENVIRONMENT; SURVIVAL AB In 2001 the U.S. Army Corps of Engineers, Portland District (OR, USA), started developing the Juvenile Salmon Acoustic Telemetry System, a nonproprietary sensing technology, to meet the needs for monitoring the survival of juvenile salmonids through eight large hydroelectric facilities within the Federal Columbia River Power System (FCRPS). Initial development focused on coded acoustic microtransmitters and autonomous receivers that could be deployed in open reaches of the river for detection of the juvenile salmonids implanted with microtransmitters as they passed the autonomous receiver arrays. In 2006, the Pacific Northwest National Laboratory began the development of an acoustic receiver system for deployment at hydropower facilities (cabled receiver) for detecting fish tagged with microtransmitters as well as tracking them in two or three dimensions for determining route of passage and behavior as the fish passed at the facility. The additional information on route of passage, combined with survival estimates, is used by the dam operators and managers to make structural and operational changes at the hydropower facilities to improve survival of fish as they pass the facilities through the FCRPS. C1 [Weiland, Mark A.; Deng, Z. Daniel; Seim, Tom A.; LaMarche, Brian L.; Choi, Eric Y.; Fu, Tao; Carlson, Thomas J.; Thronas, Aaron I.] Pacific NW Natl Lab, Richland, WA 99332 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA. RP Weiland, MA (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA. EM mark.weiland@pnl.gov; zhiqun.deng@pnl.gov; Thomas.Seim@pnl.gov; brian.lamarche@pnl.gov; eric.choi@pnl.gov; tao.fu@pnnl.gov; thomas.carlson@pnl.gov; aaron.thronas@pnnl.gov; matthew.b.eppard@usace.army.mil RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers, Portland District FX The work described in this article was funded by the U.S. Army Corps of Engineers, Portland District. The study was conducted at Pacific Northwest National Laboratory (PNNL) in Richland, Washington, which is operated by Battelle for the U.S. Department of Energy. The authors thank Robert Wertheimer of the USACE and Derrek Faber, James Hughes, Mitchell Myjak, Geoff McMichael, and Gene Ploskey of PNNL for their help with this study. Numerous staff from the Pacific States Marine Fisheries Commission and other PNNL staff from the Ecology Group, Hydrology Group, Marine Sciences Laboratory, and Instrument Development Laboratory worked hard to develop and prove this technology. Sonic Concepts Inc. provided innovative engineering, prototype development, and production of transmitters and receiving equipment. Advanced Telemetry Systems set a new standard for acoustic tag size and performance. Andrea Currie and Jayson Martinez of PNNL provided comments and technical help preparing the manuscript. The authors are also grateful to the four anonymous reviewers whose comments substantially improved the initial manuscript. NR 26 TC 32 Z9 32 U1 4 U2 12 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD JUN PY 2011 VL 11 IS 6 BP 5645 EP 5660 DI 10.3390/s110605645 PG 16 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 782RB UT WOS:000292026400007 PM 22163918 ER PT J AU Deng, ZD Weiland, MA Fu, T Seim, TA LaMarche, BL Choi, EY Carlson, TJ Eppard, MB AF Deng, Z. Daniel Weiland, Mark A. Fu, Tao Seim, Tom A. LaMarche, Brian L. Choi, Eric Y. Carlson, Thomas J. Eppard, M. Brad TI A Cabled Acoustic Telemetry System for Detecting and Tracking Juvenile Salmon: Part 2. Three-Dimensional Tracking and Passage Outcomes SO SENSORS LA English DT Article DE acoustic tracking; underwater acoustic sensors; acoustic telemetry ID PASSIVE LOCALIZATION; POSITION ACCURACY; HYDROPHONE ARRAY; LOCATION; SURVIVAL; TURBINES; WATER; INSTRUMENTATION; PERFORMANCE; ENVIRONMENT AB In Part 1 of this paper, we presented the engineering design and instrumentation of the Juvenile Salmon Acoustic Telemetry System (JSATS) cabled system, a nonproprietary sensing technology developed by the U. S. Army Corps of Engineers, Portland District (Oregon, USA) to meet the needs for monitoring the survival of juvenile salmonids through the hydroelectric facilities within the Federal Columbia River Power System. Here in Part 2, we describe how the JSATS cabled system was employed as a reference sensor network for detecting and tracking juvenile salmon. Time-of-arrival data for valid detections on four hydrophones were used to solve for the three-dimensional (3D) position of fish surgically implanted with JSATS acoustic transmitters. Validation tests demonstrated high accuracy of 3D tracking up to 100 m upstream from the John Day Dam spillway. The along-dam component, used for assigning the route of fish passage, had the highest accuracy; the median errors ranged from 0.02 to 0.22 m, and root mean square errors ranged from 0.07 to 0.56 m at distances up to 100 m. For the 2008 case study at John Day Dam, the range for 3D tracking was more than 100 m upstream of the dam face where hydrophones were deployed, and detection and tracking probabilities of fish tagged with JSATS acoustic transmitters were higher than 98%. JSATS cabled systems have been successfully deployed on several major dams to acquire information for salmon protection and for development of more "fish-friendly" hydroelectric facilities. C1 [Deng, Z. Daniel; Weiland, Mark A.; Fu, Tao; Seim, Tom A.; LaMarche, Brian L.; Choi, Eric Y.; Carlson, Thomas J.] Pacific NW Natl Lab, Richland, WA 99332 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA. RP Deng, ZD (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA. EM zhiqun.deng@pnl.gov; mark.weiland@pnl.gov; tao.fu@pnnl.gov; Thomas.Seim@pnl.gov; brian.lamarche@pnl.gov; eric.choi@pnl.gov; thomas.carlson@pnl.gov; matthew.b.eppard@usace.army.mil RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers, Portland District FX The work described in this article was funded by the U.S. Army Corps of Engineers, Portland District. The study was conducted at Pacific Northwest National Laboratory (PNNL), operated in Richland, Washington, by Battelle for the U.S. Department of Energy. The authors thank Robert Wertheimer of the USACE and Derrek Faber, James Hughes, Mitchell Myjak, Geoff McMichael, Gene Ploskey of PNNL for their help with this study. Numerous staff from the Pacific States Marine Fisheries Commission and other PNNL staff from the Ecology Group, Hydrology Group, Marine Sciences Laboratory, and Instrument Development Laboratory worked hard to develop and prove this technology. Sonic Concepts Inc. provided innovative engineering, prototype development, and production of transmitters and receiving equipment. Advanced Telemetry Systems set a new standard for acoustic tag size and performance. Andrea Currie and Jayson Martinez of PNNL provided comments and technical help preparing the manuscript. The authors are also grateful to the four anonymous reviewers whose comments substantially improved the initial manuscript. NR 38 TC 28 Z9 28 U1 4 U2 21 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD JUN PY 2011 VL 11 IS 6 BP 5661 EP 5676 DI 10.3390/s110605661 PG 16 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 782RB UT WOS:000292026400008 PM 22163919 ER PT J AU Kattke, MD Gao, EJ Sapsford, KE Stephenson, LD Kumar, A AF Kattke, Michele D. Gao, Elizabeth J. Sapsford, Kim E. Stephenson, Larry D. Kumar, Ashok TI FRET-Based Quantum Dot Immunoassay for Rapid and Sensitive Detection of Aspergillus amstelodami SO SENSORS LA English DT Article DE Fluorescence Resonance Energy Transfer (FRET); quantum dot (QD); displacement immunoassay; detection; biosensor; fluorescence; quenching; mold; fungi; spores ID RESONANCE ENERGY-TRANSFER; SEMICONDUCTOR NANOCRYSTALS; FUNGAL-INFECTIONS; FLUORESCENCE; AUTOFLUORESCENCE; DESIGN; SENSOR AB In this study, a fluorescence resonance energy transfer (FRET)-based quantum dot (QD) immunoassay for detection and identification of Aspergillus amstelodami was developed. Biosensors were formed by conjugating QDs to IgG antibodies and incubating with quencher-labeled analytes; QD energy was transferred to the quencher species through FRET, resulting in diminished fluorescence from the QD donor. During a detection event, quencher-labeled analytes are displaced by higher affinity target analytes, creating a detectable fluorescence signal increase from the QD donor. Conjugation and the resulting antibody: QD ratios were characterized with UV-Vis spectroscopy and QuantiT protein assay. The sensitivity of initial fluorescence experiments was compromised by inherent autofluorescence of mold spores, which produced low signal-to-noise and inconsistent readings. Therefore, excitation wavelength, QD, and quencher were adjusted to provide optimal signal-to-noise over spore background. Affinities of anti-Aspergillus antibody for different mold species were estimated with sandwich immunoassays, which identified A. fumigatus and A. amstelodami for use as quencher-labeled-and target-analytes, respectively. The optimized displacement immunoassay detected A. amstelodami concentrations as low as 10(3) spores/mL in five minutes or less. Additionally, baseline fluorescence was produced in the presence of 10(5) CFU/mL heat-killed E. coli O157:H7, demonstrating high specificity. This sensing modality may be useful for identification and detection of other biological threat agents, pending identification of suitable antibodies. Overall, these FRET-based QD-antibody biosensors represent a significant advancement in detection capabilities, offering sensitive and reliable detection of targets with applications in areas from biological terrorism defense to clinical analysis. C1 [Kattke, Michele D.; Gao, Elizabeth J.; Stephenson, Larry D.; Kumar, Ashok] Erdc, US Corps Engineers, CERL, Champaign, IL 61826 USA. [Sapsford, Kim E.] US FDA, CDRH OSEL DB, Silver Spring, MD 20993 USA. RP Kattke, MD (reprint author), Erdc, US Corps Engineers, CERL, 2902 Newmark Dr, Champaign, IL 61826 USA. EM Michele.D.Kattke@usace.army.mil; Elizabeth.J.Gao@usace.army.mil; kim.sapsford@fda.hhs.gov; Larry.D.Stephenson@usace.army.mil; Ashok.Kumar@usace.army.mil FU U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory FX The authors sincerely thank Igor Medintz for his consultation and advice regarding the project. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and ERDC-CERL. NR 25 TC 23 Z9 23 U1 4 U2 60 PU MDPI AG PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD JUN PY 2011 VL 11 IS 6 BP 6396 EP 6410 DI 10.3390/s110606396 PG 15 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 782RB UT WOS:000292026400051 PM 22163961 ER PT J AU Harrison, AB George, SG Slack, WT AF Harrison, Audrey B. George, Steven G. Slack, William T. TI Nymphal Cicadas (Hemiptera: Cicadidae) as a Prey Item of Shovelnose Sturgeon (Scaphirhynchus platorynchus) in the Lower Mississippi River SO SOUTHEASTERN NATURALIST LA English DT Article ID PALLID STURGEON; MISSOURI RIVER; SOUTH-DAKOTA; MIDDLE; FOOD AB Stomach contents of 3 Scaphirhynchus platorynchus (Shovelnose Sturgeon) collected in the Lower Mississippi River in January 2010 yielded 44 specimens of cicada nymphs, Diceroprocta sp. The fish were collected during a sudden rise in water level. The floodplain-dwelling cicada were likely washed out of their terrestrial habitat and into the river, where opportunistic sturgeon were foraging. C1 [Harrison, Audrey B.; George, Steven G.; Slack, William T.] USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Harrison, AB (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Audrey.B.Harrison@usace.army.mil FU US Army Corps of Engineers office, Mississippi Valley Division; US Army Corps of Engineers office, New Orleans District; US Army Corps of Engineers office, Dredging Operation and Environmental Research Program of the ERDC FX This project was supported by three US Army Corps of Engineers offices: the Mississippi Valley Division, the New Orleans District, and the Dredging Operation and Environmental Research Program of the ERDC. We thank the US Army ERDC-EL Fish Ecology Team, Vicksburg, MS for their work in the field collecting and processing the sturgeon used in this analysis. Dr. Bill Stark of Mississippi College and Dr. Allen Sanborn of Barry University confirmed the identification of the cicadas. The manuscript was reviewed by Bill Stark, Jan Hoover, and Jack Killgore. Permission was granted byt the Chief of Engineers to publish this information. NR 16 TC 2 Z9 2 U1 0 U2 4 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD JUN PY 2011 VL 10 IS 2 BP 371 EP 373 DI 10.1656/058.010.0216 PG 3 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 976SS UT WOS:000306605700016 ER PT J AU Schillaci, J AF Schillaci, Jessica TI American Kestrel (Falco sparverius) Attacks Red-cockaded Woodpecker (Picoides borealis) Fledgling SO SOUTHEASTERN NATURALIST LA English DT Article ID HABITAT; FLORIDA; SELECTION; SUCCESS AB A Falco sparverius (American Kestrel) was observed attacking and carrying away a Picoides borealis (Red-cockaded Woodpecker) fledgling during observations associated with a long-term monitoring program on Fort Bragg Military Installation, Fort Bragg, NC. The woodpecker was released in mid-air approximately 100 m from the site of the attack and fell to the ground, alive. It is unknown if the American kestrel returned to consume the fledgling, or if the fledgling survived the encounter. C1 IMSE BRG PWE E, Directorate Publ Works, Ft Bragg, NC 28310 USA. RP Schillaci, J (reprint author), IMSE BRG PWE E, Directorate Publ Works, 2175 Reilly Rd Stop A, Ft Bragg, NC 28310 USA. EM Jessie.schillaci@us.army.mil NR 19 TC 0 Z9 0 U1 0 U2 6 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PD JUN PY 2011 VL 10 IS 2 BP 378 EP 380 DI 10.1656/058.010.0218 PG 3 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 976SS UT WOS:000306605700018 ER PT J AU Helgeson, MD Lehman, RA Patzkowski, JC Dmitriev, AE Rosner, MK Mack, AW AF Helgeson, Melvin D. Lehman, Ronald A., Jr. Patzkowski, Jeanne C. Dmitriev, Anton E. Rosner, Michael K. Mack, Andrew W. TI Adjacent vertebral body osteolysis with bone morphogenetic protein use in transforaminal lumbar interbody fusion SO SPINE JOURNAL LA English DT Article DE Osteolysis; Resorption; Transforaminal lumbar interbody fusion; Bone morphogenetic protein ID RHBMP-2; ALLOGRAFT; RESORPTION; OUTCOMES AB BACKGROUND CONTEXT: Recent studies have demonstrated cases of adjacent vertebral body osteolysis when assessing the effect of bone morphogenetic protein (BMP) on fusion rates. However, no study to date has evaluated the course of osteolysis at different periods. PURPOSE: To determine the incidence and resolution of osteolysis associated with BMP used in transforaminal lumbar interbody fusions (TLIF). STUDY DESIGN: Retrospective review. PATIENT SAMPLE: All TLIF cases using BMP performed at one institution with routine postoperative computed tomography (CT) scans at defined intervals. OUTCOME MEASURES: Area of osteolysis and fusion as determined by CT scan. METHODS: We performed a retrospective analysis of all patients at our facility who underwent TLIF with BMP. Included were all patients who had obtained a CT scan within 48 hours of surgery, 3 to 6 months postoperatively, and 1 to 2 years postoperatively. Areas of osteolysis were defined as lucency within the vertebral body communicating with the interbody spacer that was not present on the immediately postoperative CT scan. Areas of osteolysis were measured in all three planes and the volume used for comparison of the 3 to 6 months CT scans with the greater than 1 year CT scan. RESULTS: Twenty-three patients who underwent TLIF with BMP had obtained CT scans at all time periods required for evaluation. Seventy-eight vertebral bodies/end plates were assessed for osteolysis (39 levels). The incidence of osteolysis 3 to 6 months postoperatively in the adjacent vertebral bodies was 54% compared with 41% at 1 to 2 years. The mean volume of osteolysis was at 0.216 cm(3) at 1 to 2 years compared with 0.306 cm(3) at 3 to 6 months (p-.082). The area/rate of osteolysis did not appear to significantly affect the rate of fusion or final outcome with an overall union rate of 83%. CONCLUSIONS: The rate of osteolysis decreased at 1 year compared with 3 to 6 months, but only 24% of the vertebral bodies with evidence of osteolysis at 3 to 6 months completely resolved by 1 year. Published by Elsevier Inc. C1 [Helgeson, Melvin D.; Mack, Andrew W.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Dmitriev, Anton E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Spine Res Lab, Washington, DC 20307 USA. [Patzkowski, Jeanne C.] Brooke Army Med Ctr, Dept Orthopaed Surg, San Antonio, TX 78234 USA. [Rosner, Michael K.] Walter Reed Army Med Ctr, Dept Surg, Neurosurg Serv, Washington, DC 20307 USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. EM armyspine@yahoo.com FU Medtronic Spine Biologics; Other: Defense Advanced Research Projects Agency; Defense Advanced Research Projects Agency FX Research Support (Staff and/or Materials): Medtronic Spine Biologics (A, Paid directly to institution/employer); Other: Defense Advanced Research Projects Agency (Financial, G, Paid directly to institution/employer); Relationships Outside the One-Year Requirement: Medtronic Spine Biologics (12/2008, D), Defense Advanced Research Projects Agency (Financial, H, Paid directly to institution/employer). NR 10 TC 45 Z9 46 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD JUN PY 2011 VL 11 IS 6 BP 507 EP 510 DI 10.1016/j.spinee.2011.01.017 PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 786PJ UT WOS:000292320100008 PM 21729801 ER PT J AU Belard, A Dolney, D Zelig, T McDonough, J O'Connell, J AF Belard, Arnaud Dolney, Derek Zelig, Tochner McDonough, James O'Connell, John TI Improving Proton Therapy Accessibility Through Seamless Electronic Integration of Remote Treatment Planning Sites SO TELEMEDICINE AND E-HEALTH LA English DT Article DE Cancer; radiation therapy; virtual medical simulation; remote treatment planning ID CANCER-CARE; TELEMEDICINE; HEALTH; EDUCATION; SYSTEM; INTERNET; COLLABORATION; TELERADIOLOGY; SERVICES; ONCOLOGY AB Objectives: Proton radiotherapy is a relatively scarce treatment modality in radiation oncology, with only nine centers currently operating in the United States. Funded by Public Law 107-248, the University of Pennsylvania and the Walter Reed Army Medical Center have developed a remote proton radiation therapy solution with the goals of improving access to proton radiation therapy for Department of Defense (DoD) beneficiaries while minimizing treatment delays and time spent away from home/work (time savings of up to 3 weeks per patient). Materials and Methods: To meet both Health Insurance Portability and Accountability Act guidelines and the more stringent security restrictions imposed by the DoD, our program developed a hybrid remote proton radiation therapy solution merging a CITRIX server with a JITIC-certified (Joint Interoperability Test Command) desktop videoconferencing unit. This conduit, thoroughly tested over a period of 6 months, integrates both institutions' radiation oncology treatment planning infrastructures into a single entity for DoD patients' treatment planning and delivery. Results: This telemedicine solution enables DoD radiation oncologists and medical physicists the ability to (1) remotely access a proton therapy treatment planning platform, (2) transfer patient plans securely to the University of Pennsylvania patient database, and (3) initiate ad-hoc point-to-point and multipoint videoconferences to dynamically optimize and validate treatment plans. Conclusions: Our robust and secure remote treatment planning solution grants DoD patients not only access to a state-of-the-art treatment modality, but also participation in the treatment planning process by Walter Reed Army Medical Center radiation oncologists and medical physicists. This telemedicine system has the potential to lead to a greater integration of military treatment facilities and/or satellite clinics into regional proton therapy centers. C1 [Belard, Arnaud] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Belard, Arnaud; O'Connell, John] Walter Reed Army Med Ctr, Dept Radiol, Radiat Oncol Serv, Washington, DC 20307 USA. [Dolney, Derek; Zelig, Tochner; McDonough, James] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA. RP Belard, A (reprint author), Henry M Jackson Fdn Adv Mil Med, 6900 Georgia Ave NW,Bldg 2,Room 1H46A, Washington, DC 20307 USA. EM arnaud.belard@amedd.army.mil FU US Army Medical Research and Material Command [DAMD17W81XWH-04-2-0022, W81XWH0720121] FX This work was supported by the US Army Medical Research and Material Command (DAMD17W81XWH-04-2-0022 and W81XWH0720121). Our research program further recognizes the contributions of the following individuals for their efforts: Lew Harvey, Nyere Hollingsworth, Desire Duckett, and Margaret Russell from WRAMC-Directorate of Information Management; and Brendten Eickstaedt, Scott Galper, Gary Robinson, Teresa Corbo, and Heathyr McNiece from the UPenn Health System. Mr. Chuck Martin (Varian Medical Systems) was also instrumental in helping to configure the CITRIX solution. Additionally, the authors thank COL(R) Michael Brazaitis, M.D., former chairman of the Department of Radiology at WRAMC, for the resources provided to further this work. NR 34 TC 3 Z9 3 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD JUN PY 2011 VL 17 IS 5 BP 370 EP 375 DI 10.1089/tmj.2010.0199 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 784ZX UT WOS:000292198300010 PM 21492029 ER PT J AU Lang, ET Peterson, MS Slack, WT AF Lang, Erik T. Peterson, Mark S. Slack, William T. TI Comparative development of five sympatric coastal Fundulid species from the northern Gulf of Mexico SO ZOOTAXA LA English DT Article DE Fundulidae; Adinia xenica; Fundulus grandis; Fundulus jenkinsi; Fundulus pulvereus; Fundulus similis; larvae; dichotomous key; morphometrics; diagnostic pigments; meristics ID SALT-MARSH TOPMINNOW; LIFE-HISTORY; PISCES CYPRINODONTIDAE; SPOTFIN KILLIFISH; DIAMOND KILLIFISH; ADINIA-XENICA; HETEROCLITUS; HABITAT; PATTERNS; LUCIAE AB There are five coastal fundulid species in the northern Gulf of Mexico (nGOM) including Fundulus jenkinsi, which is recognized within all states from Louisiana through Florida and federally as a Species of Concern. This particular fundulid was listed because of a perceived linkage to salt marsh habitat, only scant data available on its ecology, and salt marsh habitat being altered throughout its range. Little is known about the life history of this coastal killifish, but a detailed diagnostic key of the early life stages of select members of Fundulidae can provide the foundation needed to accurately identify this rare species in need of conservation. Larval and postlarval stages of select members of the family Fundulidae along the east coast of the U. S. have been described and compared among species. We illustrated various stages of coastal Fundulus spp. and Adinia xenica in the northern GOM and quantified morphometric and meristic characters. Total length, head length, body depth, caudal peduncle width, snout length, eye diameter, anal and dorsal fin counts, and diagnostic pigment patterns were compared among species. The first branch of our dichotomous key utilized the number of branchiostegal rays to separate young fundulids (< 15 mm TL) into two groups that can then be identified by selected pigment patterns, morphometrics, and meristics. C1 [Lang, Erik T.; Peterson, Mark S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA. [Slack, William T.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn EE A 3909, Vicksburg, MS 39180 USA. RP Lang, ET (reprint author), Univ So Mississippi, Dept Coastal Sci, 703 E Beach Dr, Ocean Springs, MS 39564 USA. EM erik.lang@eagles.usm.edu; mark.peterson@usm.edu; todd.slack@usace.army.mil FU USFWS; Mississippi Museum of Natural Science under the Mississippi Department of Wildlife Fisheries and Parks FX First, thanks to the USFWS in conjunction with the Mississippi Museum of Natural Science under the Mississippi Department of Wildlife Fisheries and Parks for funding this project. We would also like to thank Bruce Comyns and Nancy Brown-Peterson for their input on previous drafts of this paper. A special thanks to Steve Manning, who lent tanks and space to raise larvae. Others who have helped along the way to produce the final product of this endeavor are P.O. Grammar, M. R. Lowe, and M.J. Andres. This research was conducted with a sampling permit of the state of Mississippi, and was approved and performed under the University of Southern Mississippi IACUC protocol # 10040802. NR 47 TC 2 Z9 3 U1 0 U2 2 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD JUN 1 PY 2011 IS 2901 BP 1 EP 18 PG 18 WC Zoology SC Zoology GA 772IS UT WOS:000291228200001 ER PT J AU Ringelberg, DB Foley, KL Reynolds, CM AF Ringelberg, David B. Foley, Karen L. Reynolds, Charles M. TI Electrogenic capacity and community composition of anodic biofilms in soil-based bioelectrochemical systems SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Bioelectrochemical system (BES); Anode biofilm; Community composition ID MICROBIAL FUEL-CELLS; RIBOSOMAL-RNA GENES; ELECTRICITY-GENERATION; 16S; ENRICHMENT; SEDIMENTS; PROFILES; CHAMBER AB Although a number of bacteria are known to be capable of generating an electrical current, the diversity of electrogenic bacteria in soils and the commonality across soil types is relatively unknown. Simple bioelectrochemical cells were constructed to measure the electrogenic capacity and community composition of bacteria originating on cell anodes from three biogeochemically distinct soil types. All three soils supported electrogenic activity, amounting to a maximum sustained current of 1.5-2.1 mA over 55 days. Analysis of fatty acids identified differences in microbial community composition between anode biofilms and far-field soil materials. Anode communities showed greater percentages of fatty acids indicative of Gram-negative bacteria and Actinomycetes. By analysis of anode biofilm genomic DNA via terminal-restriction fragment-length polymorphisms, commonalities in community composition across the three soil types were identified, specifically, the putative presence of bacterial species belonging to the alpha- and -Proteobacteria and the Firmicutes. Subsequent culture and isolation of bacteria from the anodes confirmed the presence of similar classes of bacteria. Results showed that, under saturated conditions, different soils can support electrogenic activity and that the bacterial communities that develop on the anodes share certain common inherent community traits. C1 [Ringelberg, David B.] USA, ERDC CRREL, Hanover, NH 03755 USA. [Ringelberg, David B.; Foley, Karen L.; Reynolds, Charles M.] USA, Cold Reg Res & Engn Ctr, Hanover, NH 03755 USA. RP Ringelberg, DB (reprint author), USA, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM david.b.ringelberg@usace.army.mil NR 29 TC 11 Z9 19 U1 7 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD JUN PY 2011 VL 90 IS 5 BP 1805 EP 1815 DI 10.1007/s00253-011-3264-9 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 763SQ UT WOS:000290580400019 PM 21503759 ER PT J AU Zhang, C Zheng, JH Wang, YG Demirbilek, Z AF Zhang, Chi Zheng, Jinhai Wang, Yigang Demirbilek, Zeki TI Modeling wave-current bottom boundary layers beneath shoaling and breaking waves SO GEO-MARINE LETTERS LA English DT Article ID DIFFERENT WATER DEPTHS; K-EPSILON MODEL; SEDIMENT TRANSPORT; ASYMMETRICAL WAVES; SANDBAR MIGRATION; SHEAR-STRESS; PLUS CURRENT; CURRENT FLOW; SHEET FLOW; SURF ZONE AB The boundary layer characteristics beneath waves transforming on a natural beach are affected by both waves and wave-induced currents, and their predictability is more difficult and challenging than for those observed over a seabed of uniform depth. In this research, a first-order boundary layer model is developed to investigate the characteristics of bottom boundary layers in a wave-current coexisting environment beneath shoaling and breaking waves. The main difference between the present modeling approach and previous methods is in the mathematical formulation for the mean horizontal pressure gradient term in the governing equations for the cross-shore wave-induced currents. This term is obtained from the wave-averaged momentum equation, and its magnitude depends on the balance between the wave excess momentum flux gradient and the hydrostatic pressure gradient due to spatial variations in the wave field of propagating waves and mean water level fluctuations. A turbulence closure scheme is used with a modified low Reynolds number k-epsilon model. The model was validated with two published experimental datasets for normally incident shoaling and breaking waves over a sloping seabed. For shoaling waves, model results agree well with data for the instantaneous velocity profiles, oscillatory wave amplitudes, and mean velocity profiles. For breaking waves, a good agreement is obtained between model and data for the vertical distribution of mean shear stress. In particular, the model reproduced the local onshore mean flow near the bottom beneath shoaling waves, and the vertically decreasing pattern of mean shear stress beneath breaking waves. These successful demonstrations for wave-current bottom boundary layers are attributed to a novel formulation of the mean pressure gradient incorporated in the present model. The proposed new formulation plays an important role in modeling the boundary layer characteristics beneath shoaling and breaking waves, and ensuring that the present model is applicable to nearshore sediment transport and morphology evolution. C1 [Zhang, Chi; Zheng, Jinhai] Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Peoples R China. [Wang, Yigang] Hohai Univ, Key Lab Coastal Disaster & Def, Minist Educ, Nanjing 210098, Peoples R China. [Demirbilek, Zeki] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Zheng, JH (reprint author), Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, 1 Xikang Rd, Nanjing 210098, Peoples R China. EM jhzheng@hhu.edu.cn FU National Natural Science Foundation of China [50979033]; Program for New Century Excellent Talents in University of China [NCET-07-0255]; Special Research Funding of State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering [2009585812] FX The work was supported by the National Natural Science Foundation of China (Grant No. 50979033), the Program for New Century Excellent Talents in University of China (NCET-07-0255), and the Special Research Funding of State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering (Grant No. 2009585812). The authors thank two anonymous reviewers for their valuable comments that have improved the quality of the paper. NR 57 TC 14 Z9 17 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0276-0460 EI 1432-1157 J9 GEO-MAR LETT JI Geo-Mar. Lett. PD JUN PY 2011 VL 31 IS 3 BP 189 EP 201 DI 10.1007/s00367-010-0224-9 PG 13 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 763QQ UT WOS:000290575200005 ER PT J AU Jung, CM Crocker, FH Eberly, JO Indest, KJ AF Jung, C. M. Crocker, F. H. Eberly, J. O. Indest, K. J. TI Horizontal gene transfer (HGT) as a mechanism of disseminating RDX-degrading activity among Actinomycete bacteria SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE conjugation; degradation; Gordonia; hexahydro-1; 3; 5-trinitro-1; 3; 5; -triazine; horizontal gene transfer; pGKT2 ID ACID 2,4-D DEGRADATION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; STRAIN DN22; EXPLOSIVE HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; RHODOCOCCUS; PLASMIDS; SOIL; BIODEGRADATION; COMMUNITY; GORDONIA AB Aims: Hexahydro-1,3,5-trinitro-1,3,5,-triazine (RDX) is a cyclic nitramine explosive that is a major component in many high-explosive formulations and has been found as a contaminant of soil and groundwater. The RDX-degrading gene locus xplAB, located on pGKT2 in Gordonia sp. KTR9, is highly conserved among isolates from disparate geographical locations suggesting a horizontal gene transfer (HGT) event. It was our goal to determine whether Gordonia sp. KTR9 is capable of transferring pGKT2 and the associated RDX degradation ability to other bacteria. Methods and Results: We demonstrate the successful conjugal transfer of pGKT2 from Gordonia sp. KTR9 to Gordonia polyisoprenivorans, Rhodococcus jostii RHA1 and Nocardia sp. TW2. Through growth and RDX degradation studies, it was demonstrated that pGKT2 conferred to transconjugants the ability to degrade and utilize RDX as a nitrogen source. The inhibitory effect of exogenous inorganic nitrogen sources on RDX degradation in transconjugant strains was found to be strain specific. Conclusions: Plasmid pGKT2 can be transferred by conjugation, along with the ability to degrade RDX, to related bacteria, providing evidence of at least one mechanism for the dissemination and persistence of xplAB in the environment. Significance and Impact of Study: These results provide evidence of one mechanism for the environmental dissemination of xplAB and provide a framework for future field relevant bioremediation practices. C1 [Indest, K. J.] USA, Environm Lab, CEERDC EP P, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Indest, KJ (reprint author), USA, Environm Lab, CEERDC EP P, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Karl.J.Indest@usace.army.mil FU US Army [ER1609] FX This research was funded through the US Army Corps of Engineers Environmental Quality Program and SERDP (project ER1609). Views, opinions and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision unless so designated by other official documentation. Mycobacterium strains were kindly provided by John B. Sutherland at the US FDA National Center for Toxicological Research, Jefferson, AR; the Nocardia, Nocardioides and Arthrobacter strains by Larry F. Hanne at California State University, Chico, CA; and Rhodococcus jostii RHA1 by Lindsay Eltis at the University of British Columbia. We thank Ryan Carbone and Caly Bodeis for technical assistance. NR 50 TC 15 Z9 15 U1 2 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1364-5072 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD JUN PY 2011 VL 110 IS 6 BP 1449 EP 1459 DI 10.1111/j.1365-2672.2011.04995.x PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 763CX UT WOS:000290532800009 PM 21395947 ER PT J AU Hinchey, SA Jackson, JL AF Hinchey, Sherri A. Jackson, Jeffrey L. TI A Cohort Study Assessing Difficult Patient Encounters in a Walk-In Primary Care Clinic, Predictors and Outcomes SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article ID MENTAL-DISORDERS; PHYSICIAN; COMMUNICATION; MEDICINE; PSYCHOPATHOLOGY; PREVALENCE; SYMPTOMS; MILITARY; VISITS; IMPACT AB BACKGROUND: Previous studies have found that up to 15% of clinical encounters are experienced as difficult by clinicians. OBJECTIVES: Explore patient and physician characteristics associated with being considered "difficult" and assess the impact on patient outcomes. DESIGN: Prospective cohort study. PARTICIPANTS: Seven hundred fifty adults presenting to a primary care walk-in clinic with a physical symptom. MAIN MEASURES: Pre-visit surveys assessed symptom characteristics, expectations, functional status (Medical Outcome Study SF-6) and the presence of mental disorders [Primary Care Evaluation of Mental Disorders, (PRIME-MD)]. Post-visit surveys assessed satisfaction (Rand-9), unmet expectations and trust. Two-week assessment included symptom outcome (gone, better, same, worse), functional status and satisfaction. After each visit, clinicians rated encounter difficulty using the Difficult Doctor-Patient Relationship Questionnaire (DDPRQ). Clinicians also completed the Physician's Belief Scale, a measure of psychosocial orientation. KEY RESULTS: Among the 750 subjects, 133 (17.8%) were perceived as difficult. "Difficult" patients were less likely to fully trust (RR = 0.88, 95% CI: 0.77-0.99) or be fully satisfied (RR = 0.78, 95% CI: 0.62-0.98) with their clinician, and were more likely to have worsening of symptoms at 2 weeks (RR = 0.75, 95% CI: 0.57-0.97). Patients involved in "difficult encounters" had more than five symptoms (RR = 1.8, 95% CI: 1.3-2.3), endorsed recent stress (RR = 1.9, 95% CI: 1.4-3.2) and had a depressive or anxiety disorder (RR = 2.3, 95% CI: 1.3-4.2). Physicians involved in difficult encounters were less experienced (12 years vs. 9 years, p = 0.0002) and had worse psychosocial orientation scores (77 vs. 67, p < 0.005). CONCLUSION: Both patient and physician characteristics are associated with "difficult" encounters, and patients involved in such encounters have worse short-term outcomes. C1 [Jackson, Jeffrey L.] Dept Med, Milwaukee, WI USA. [Jackson, Jeffrey L.] Zablocki Vet Adm Med Ctr, Gen Med Div, Milwaukee, WI 53295 USA. [Hinchey, Sherri A.] Tripler Army Med Ctr, Gen Med Div, Honolulu, HI 96859 USA. RP Jackson, JL (reprint author), Dept Med, 5000 W Natl Ave, Milwaukee, WI USA. EM jjackson@mcw.edu NR 33 TC 35 Z9 36 U1 2 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2011 VL 26 IS 6 BP 588 EP 594 DI 10.1007/s11606-010-1620-6 PG 7 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 763RE UT WOS:000290576600008 PM 21264521 ER PT J AU Mascari, TM Mitchell, MA Rowton, ED Foil, LD AF Mascari, T. M. Mitchell, M. A. Rowton, E. D. Foil, L. D. TI Evaluation of juvenile hormone analogues as rodent feed-through insecticides for control of immature phlebotomine sandflies SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE Phlebotomus papatasi; juvenile hormone analogues; methoprene; pyriproxyfen; sandfly control ID SAND FLIES DIPTERA; GROWTH-REGULATORS; PSYCHODIDAE AB The juvenile hormone analogues methoprene and pyriproxyfen were evaluated as rodent feed-through insecticides for control of immature stages of the sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The development and survival of P. papatasi second-instar larvae fed faeces from Syrian hamsters, Mesocricetus auratus, that had been fed a diet containing methoprene (0, 9.788, 97.88 or 978.8 p.p.m.) or pyriproxyfen (0, 9.82, 98.2 or 982 p.p.m.) were evaluated. The faeces of methoprene-treated hamsters greatly reduced the percentage of larvae that pupated at all concentrations tested and prevented adult emergence at all but the lowest concentration (9.788 p.p.m.). Pyriproxyfen prevented both pupation and adult emergence at all concentrations tested. The results of this study suggest that a control strategy using rodent baits containing juvenile hormone analogues to control phlebotomine sandflies that live in rodent burrows and feed on rodent faeces may be possible. As rodent reservoirs and vectors of Leishmania major live in close association in many parts of the Middle East, control of the transmission of the agent of zoonotic cutaneous leishmaniasis may also be possible. C1 [Mascari, T. M.] Louisiana State Univ, Dept Entomol, Ctr Agr, Agr Expt Stn, Baton Rouge, LA 70803 USA. [Mitchell, M. A.] Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USA. [Rowton, E. D.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Mascari, TM (reprint author), Louisiana State Univ, Dept Entomol, Ctr Agr, Agr Expt Stn, 402 Life Sci, Baton Rouge, LA 70803 USA. EM tmascari@agcenter.lsu.edu RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 FU U.S. Department of Defense through the Armed Forces Pest Management Board (AFPMB) FX This work was supported by a grant from the Deployed War-Fighter Protection (DWFP) Research Program, funded by the U.S. Department of Defense through the Armed Forces Pest Management Board (AFPMB). Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of the Army or the Department of Defense. This paper is published with the approval of the Director of Louisiana Agricultural Experiment Station as manuscript no. 2008-234-1593. NR 19 TC 7 Z9 7 U1 1 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JUN PY 2011 VL 25 IS 2 BP 227 EP 231 DI 10.1111/j.1365-2915.2010.00919.x PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 763VZ UT WOS:000290589100013 PM 21073493 ER PT J AU Scherer, MR Burrows, H Pinto, R Littlefield, P French, LM Tarbett, AK Schubert, MC AF Scherer, Matthew R. Burrows, Holly Pinto, Robin Littlefield, Philip French, Louis M. Tarbett, Aaron K. Schubert, Michael C. TI Evidence of Central and Peripheral Vestibular Pathology in Blast-Related Traumatic Brain Injury SO OTOLOGY & NEUROTOLOGY LA English DT Article DE Blast; Traumatic brain injury; Vestibular function testing; Videonystagmography ID NICOTINE-INDUCED NYSTAGMUS; CEREBELLAR VERMIS LESIONS; POSITIONAL VERTIGO; FUNCTIONAL DISABILITY; PSYCHIATRIC-DISORDERS; OCULAR REFLEX; DIZZINESS; COMPLAINTS; RESPONSES; HANDICAP AB Objective: To prospectively assay the vestibular and oculomotor systems of blast-exposed service members with traumatic brain injury (TBI). Study Design: Prospective, nonblinded, nonrandomized descriptive study. Setting: Tertiary care facility (Department of Defense Medical Center). Patients: Twenty-four service members recovering from blast-related TBI sustained in Iraq or Afghanistan. Interventions: Focused history and physical, videonystagmography (VNG), rotational chair, cervical vestibular-evoked myogenic potentials, computerized dynamic posturography, and self-report measures. Results: Vestibular testing confirms a greater incidence of vestibular and oculomotor dysfunction in symptomatic (vestibularlike dizziness) personnel with blast-related TBI relative to asymptomatic group members. VNG in the symptomatic group revealed abnormal nystagmus or oculomotor findings in 6 of 12 subjects tested. Similarly, rotational chair testing in this group revealed evidence of both peripheral (4/12) and central (2/12) vestibular pathology. By contrast, the asymptomatic group revealed less vestibular impairment with 1 of 10 rotational chair abnormalities. The asymptomatic group was further characterized by fewer aberrant nystagmus findings (4/12 abnormal VNGs). Computerized dynamic posturography testing revealed no significant differences between groups. Self-report measures demonstrated differences between groups. Conclusion: Vestibular function testing confirms a greater incidence of peripheral vestibular hypofunction in dizzy service members with blast-related TBI relative to those who are asymptomatic. Additionally, oculomotor abnormalities and/or nystagmus consistent with central involvement were present in 10 of the 24 study participants tested. The precise cause of these findings remains unknown. C1 [Scherer, Matthew R.] Univ Maryland, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA. [Burrows, Holly; Pinto, Robin] Army Audiol & Speech Ctr, No Washington, DC USA. [Tarbett, Aaron K.] Walter Reed Army Med Ctr, Optometry Serv, No Washington, DC USA. [French, Louis M.] Walter Reed Army Med Ctr, Traumat Brain Injury Serv, No Washington, DC USA. [Scherer, Matthew R.; Schubert, Michael C.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA. RP Scherer, MR (reprint author), Univ Maryland, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA. EM Matthew.scherer@us.army.mil OI Littlefield, Philip/0000-0002-1890-2278 NR 51 TC 19 Z9 19 U1 5 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2011 VL 32 IS 4 BP 571 EP 580 DI 10.1097/MAO.0b013e318210b8fa PG 10 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 763ME UT WOS:000290560600009 PM 21358450 ER PT J AU Tobgay, T Dorji, T Pelzom, D Gibbons, RV AF Tobgay, Tashi Dorji, Tandin Pelzom, Dorji Gibbons, Robert V. TI Progress and delivery of health care in Bhutan, the Land of the Thunder Dragon and Gross National Happiness SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Bhutan; national health programmes; delivery of health care; public health ID HERBAL MEDICINES AB P>The Himalayan Kingdom of Bhutan is rapidly changing, but it remains relatively isolated, and it tenaciously embraces its rich cultural heritage. Despite very limited resources, Bhutan is making a concerted effort to update its health care and deliver it to all of its citizens. Healthcare services are delivered through 31 hospitals, 178 basic health unit clinics and 654 outreach clinics that provide maternal and child health services in remote communities in the mountains. Physical access to primary health care is now well sustained for more than 90% of the population. Bhutan has made progress in key health indicators. In the past 50 years, life expectancy increased by 18 years and infant mortality dropped from 102.8 to 49.3 per 1000 live births between 1984 and 2008. Bhutan has a rich medical history. One of the ancient names for Bhutan was 'Land of Medicinal Herbs' because of the diverse medicinal plants it exported to neighbouring countries. In 1967, traditional medicine was included in the National Health System, and in 1971, formal training for Drungtshos (traditional doctors) and sMenpas (traditional compounders) began. In 1982, Bhutan established the Pharmaceutical and Research Unit, which manufactures, develops and researches traditional herbal medicines. Despite commendable achievements, considerable challenges lie ahead, but the advances of the past few decades bode well for the future. C1 [Gibbons, Robert V.] USA, Med Command, AFRIMS, Bangkok, Thailand. [Tobgay, Tashi; Dorji, Tandin; Pelzom, Dorji] Bhutan Minist Hlth, Thimphu, Bhutan. RP Gibbons, RV (reprint author), USA, Med Command, AFRIMS, APO, AP 96546 USA. EM robert.gibbons@afrims.org NR 28 TC 8 Z9 8 U1 1 U2 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JUN PY 2011 VL 16 IS 6 BP 731 EP 736 DI 10.1111/j.1365-3156.2011.02760.x PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 762EQ UT WOS:000290456100012 PM 21418446 ER PT J AU Anderson, AD Baker, TR Littrell, AC Mott, RL Niebuhr, DW Smoak, BL AF Anderson, A. D. Baker, T. R. Littrell, A. C. Mott, R. L. Niebuhr, D. W. Smoak, B. L. TI Seroepidemiologic Survey for Coxiella burnetii Among Hospitalized US Troops Deployed to Iraq* SO ZOONOSES AND PUBLIC HEALTH LA English DT Article DE Q fever; Coxiella burnetii; military; serosurvey; Iraq; ICD-9 ID Q-FEVER; UNITED-STATES; MILITARY; OUTBREAK; EPIDEMIOLOGY; INFECTIONS; DIAGNOSIS; FORCES AB P > Q fever is a zoonotic illness which frequently has a non-specific clinical presentation. Cases among deployed US military personnel have been reported in increasing numbers indicating an emerging at-risk occupational group. Banked serum specimens were utilized to estimate seroprevalence and risk factors among military personnel deployed to Iraq. Coxiella burnetii antibody testing was performed and epidemiologic data were analysed from 909 servicemembers. The overall number who seroconverted to Q fever was 88 (10%). The most common ICD-9 code assigned to Q fever cases was fever not otherwise specified (NOS) (45%). A combat occupational specialty was a risk factor for Q fever seroconversion (OR = 1.8, 95% CI: 1.1-2.8) as well as receiving a primary diagnosis of fever NOS (OR = 2.6, 95% CI: 1.6-4.1).These findings indicate that Q fever is a significant infectious disease threat to military personnel deployed to Iraq. A heightened awareness among physicians is necessary to ensure prompt diagnosis and treatment. C1 [Anderson, A. D.; Baker, T. R.; Littrell, A. C.; Mott, R. L.; Niebuhr, D. W.; Smoak, B. L.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.niebuhr@na.amedd.army.mil FU Department of Defense Global Emerging Infections Surveillance and Response System FX Funding for this study was provided by the Department of Defense Global Emerging Infections Surveillance and Response System. NR 33 TC 23 Z9 23 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1863-1959 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD JUN PY 2011 VL 58 IS 4 BP 276 EP 283 DI 10.1111/j.1863-2378.2010.01347.x PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA 762NK UT WOS:000290486000008 PM 20880090 ER PT J AU Pequignet, AC Becker, JM Merrifield, MA Boc, SJ AF Pequignet, A. -C. Becker, J. M. Merrifield, M. A. Boc, S. J. TI The dissipation of wind wave energy across a fringing reef at Ipan, Guam SO CORAL REEFS LA English DT Article DE Fringing reef; Hydrodynamics; Waves; Wave setup; Sea level; Friction; Wave breaking ID 2-DIMENSIONAL HORIZONTAL REEF; CORAL-REEFS; SET-UP; GENERATED FLOW; SURF ZONE; RUN-UP; TRANSFORMATION; HYDRODYNAMICS; WATER; ATTENUATION AB Field observations over a fringing reef at Ipan, Guam, during trade wind and tropical storm conditions are used to assess the transformation of sea and swell energy from the fore reef to the shoreline. Parameterizations of wave breaking and bottom friction developed for sandy beaches are found to represent the observed decay in wave energy with an increased friction coefficient. These parameterizations are incorporated into the one-dimensional energy flux balance, which is integrated across the reef to assess the effects of varying tidal range, incident wave height and reef bathymetry on the sea and swell band wave height and wave setup near the shoreline. Wave energy on the reef is strongly depth-limited and controlled by the reef submergence level. Shoreline wave energy increases with incident wave height largely due to the increase in water level from breaking wave setup. Increased tidal levels result in increased shoreline energy, since wave setup is only weakly reduced. The wave height at the shore is shown to be inversely proportional to the width of the reef flat due to dissipation. C1 [Pequignet, A. -C.; Merrifield, M. A.] Univ Hawaii Manoa, Dept Oceanog, Honolulu, HI 96822 USA. [Becker, J. M.] Univ Hawaii Manoa, Dept Geol & Geophys, Honolulu, HI 96822 USA. [Boc, S. J.] USA, Corps Engineers, Vicksburg, MS 39183 USA. RP Pequignet, AC (reprint author), Univ Hawaii Manoa, Dept Oceanog, 1000 Pope Rd, Honolulu, HI 96822 USA. EM chrispeq@hawaii.edu; jbecker@soest.hawaii.edu; markm@soest.hawaii.edu; Stanley.J.Boc@usace.army.mil RI Pequignet, Christine/H-5618-2014 FU University of California, San Diego [PO 10230553]; National Oceanic and Atmospheric Administration [R/EP-31]; University of Hawaii Sea Grant College; SOEST; NOAA Office of Sea Grant [NA05OAR4171048]; Department of Commerce. FX We thank J. Miller and the staff of the University of Guam Marine Laboratory, and C. Kontoes, O. Vetter, T. Hilmer, C. Quisenberry, J. Aucan, K. Millikan, Y. Firing, G. Rocheleau, A. Fetheroff, and P. Lethaby from SOEST, University of Hawaii for their outstanding contributions to the field operations in Guam. The wave buoy data were provided by the Coastal Data Information Program (CDIP) at the University of California, San Diego (UCSD). PILOT project support provided by J. Thomas (UCSD) and R. Jensen and A. Garcia (US-ACE) is greatly appreciated. The two reviewers and the topic editor's comments are appreciated. PILOT was funded by the U.S. Army Corps of Engineers via a subcontract PO 10230553 from the University of California, San Diego. ACP was partially funded by a grant/cooperative agreement from the National Oceanic and Atmospheric Administration, Project R/EP-31, which is sponsored by the University of Hawaii Sea Grant College Program, SOEST, under Institutional Grant No. NA05OAR4171048 from NOAA Office of Sea Grant, Department of Commerce. The views expressed herein are those of the authors and do not necessarily reflect the views of NOAA or any of its subagencies. NR 41 TC 24 Z9 25 U1 0 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0722-4028 J9 CORAL REEFS JI Coral Reefs PD JUN PY 2011 VL 30 SU 1 SI SI BP 71 EP 82 DI 10.1007/s00338-011-0719-5 PG 12 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 760LE UT WOS:000290325000007 ER PT J AU Wu, ZJ Luo, ZQ Rastogia, A Stavchansky, S Bowman, PD Ho, PS AF Wu, Zhuo-Jie Luo, Zhiquan Rastogia, Ashish Stavchansky, Salomon Bowman, Phillip D. Ho, Paul S. TI Micro-fabricated perforated polymer devices for long-term drug delivery SO BIOMEDICAL MICRODEVICES LA English DT Article DE Drug delivery device; Microfabrication; Polymer tube; Polyimide ID CRACKING; RELEASE; FILM AB Fabrication techniques have been developed to produce a perforated polymer microtube as a drug delivery device. The technique consists of first forming a silicon platform with trenches and alignment marks to hold the tubes for subsequent processing. Photolithography and reactive ion etching with an inductively coupled plasma source were used to fabricate micro holes on the surface of polyimide tubes. Several materials have been used to form the etching mask, including titanium film deposited by e-beam evaporation and SiO(2) and SiN(x) films deposited by high-density plasma chemical vapor deposition (HDPCVD). Three equidistant holes of 20 mu m in diameter were fabricated on polyimide tubes (I.D. = 125 mu m). The perforated tubes were loaded with ethinyl estradiol and tested for drug release in phosphate buffered saline (pH = 7.1) at 37A degrees C. Zero order release was observed over a period of 30 days with a potential to be extended to 4 years. C1 [Wu, Zhuo-Jie; Luo, Zhiquan; Ho, Paul S.] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. [Rastogia, Ashish; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Rastogia, Ashish; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Ho, PS (reprint author), Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. EM paulho@mail.utexas.edu RI Wu, Zhuojie/K-7484-2012 NR 22 TC 8 Z9 8 U1 0 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-2176 J9 BIOMED MICRODEVICES JI Biomed. Microdevices PD JUN PY 2011 VL 13 IS 3 BP 485 EP 491 DI 10.1007/s10544-011-9516-8 PG 7 WC Engineering, Biomedical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA 757PG UT WOS:000290099600007 PM 21347826 ER PT J AU Wu, ZJ Luo, ZQ Rastogi, A Stavchansky, S Bowman, PD Ho, PS AF Wu, Zhuo-Jie Luo, Zhiquan Rastogi, Ashish Stavchansky, Salomon Bowman, Phillip D. Ho, Paul S. TI Micro-fabricated perforated polymer devices for long-term drug delivery (vol 13, pg 485, 2011) SO BIOMEDICAL MICRODEVICES LA English DT Correction C1 [Wu, Zhuo-Jie; Luo, Zhiquan; Ho, Paul S.] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. [Rastogi, Ashish; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Rastogi, Ashish; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Ho, PS (reprint author), Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. EM paulho@mail.utexas.edu RI Wu, Zhuojie/K-7484-2012 NR 1 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-2176 J9 BIOMED MICRODEVICES JI Biomed. Microdevices PD JUN PY 2011 VL 13 IS 3 BP 597 EP 597 DI 10.1007/s10544-011-9525-7 PG 1 WC Engineering, Biomedical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA 757PG UT WOS:000290099600019 ER PT J AU Myers, TM Langston, JL AF Myers, Todd M. Langston, Jeffrey L. TI Diet composition exacerbates or attenuates soman toxicity in rats: Implied metabolic control of nerve agent toxicity SO NEUROTOXICOLOGY LA English DT Article DE Organophosphorus nerve agent; Soman; Diet composition; Survival; Active avoidance behavior; Rat ID PARATHION-INDUCED NEUROTOXICITY; INDUCED MEMORY IMPAIRMENT; ESTERASE-1 ES-1 ACTIVITY; HIGH-FAT DIETS; KETOGENIC DIET; BLOOD-GLUCOSE; CHOLINE SUPPLEMENTATION; KETONE-BODIES; SEIZURE SUSCEPTIBILITY; ACETYLCHOLINE-RELEASE AB To evaluate the role of diet composition on nerve agent toxicity, rats were fed four distinct diets ad libitum for 28 d prior to challenge with 110 mu g/kg (1.0 LD(50), sc) soman. The four diets used were a standard rodent diet, a choline-enriched diet, a glucose-enriched diet, and a ketogenic diet. Body weight was recorded throughout the study. Toxic signs and survival were evaluated at key times for up to 72 h following soman exposure. Additionally, acquisition of discriminated shuttlebox avoidance performance was characterized beginning 24 h after soman challenge and across the next 8 d (six behavioral sessions). Prior to exposure, body weight was highest in the standard diet group and lowest in the ketogenic diet group. Upon exposure, differences in soman toxicity as a function of diet became apparent within the first hour, with mortality in the glucose-enriched diet group reaching 80% and exceeding all other groups (in which mortality ranged from 0 to 6%). At 72 h after exposure, mortality was 100% in the glucose-enriched diet group, and survival approximated 50% in the standard and choline-enriched diet groups, but equaled 87% in the ketogenic diet group. Body weight loss was significantly reduced in the ketogenic and choline-enriched diet groups, relative to the standard diet group. At 1 and 4 h after exposure, rats in the ketogenic diet group had significantly lower toxic sign scores than all other groups. The ketogenic diet group performed significantly better than the standard diet group on two measures of active avoidance performance. The exacerbated soman toxicity observed in the glucose-enriched diet group coupled with the attenuated soman toxicity observed in the ketogenic diet group implicates glucose availability in the toxic effects of soman. This increased glucose availability may enhance acetylcholine synthesis and/or utilization, thereby exacerbating peripheral and central soman toxicity. Published by Elsevier Inc. C1 [Myers, Todd M.; Langston, Jeffrey L.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Myers, TM (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Todd.Myers2@us.army.mil FU Defense Threat Reduction Agency, Medical ST Division; U.S. Army Medical Research Institute of Chemical Defense; U.S. Department of Energy; USAMRMC FX This research was supported by the Defense Threat Reduction Agency, Medical S&T Division.; This research was supported in part by an appointment to the Postgraduate Research Participation Program (JLL) at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 76 TC 4 Z9 5 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD JUN PY 2011 VL 32 IS 3 BP 342 EP 349 DI 10.1016/j.neuro.2011.03.001 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 755JK UT WOS:000289925800007 PM 21396400 ER PT J AU Alfredsson, KS Gawandi, AA Gillespie, JW Carlsson, LA Bogetti, TA AF Alfredsson, K. S. Gawandi, A. A. Gillespie, J. W., Jr. Carlsson, L. A. Bogetti, T. A. TI Stress analysis of axially and thermally loaded discontinuous tile core sandwich with and without adhesive filled core gaps SO COMPOSITE STRUCTURES LA English DT Article DE Sandwich; Adhesive; Stresses; Compliance; Interlaminar ID VARIATIONAL APPROACH AB An analytical study is performed to investigate the stress states in an axially and thermally loaded sandwich structure with a discontinuous ceramic tile core. General and simplified models are developed to determine stresses in the constituents of the sandwich structure with and without adhesive in the gaps between adjacent tiles. A general model that allows local bending of the face sheet and a simplified model which assumes uniform through-thickness stress distribution in the face sheets are developed. It is shown that the normal stress in the face sheet decreases when the gap is filled by adhesive, although the tile stress increases. The analytical model shows that normal and shear stresses at the face/core interface can be reduced by filling the gaps between tiles. Filled gaps also elevate the axial stiffness of the structure. Model results are verified by comparison to a previously developed analytical model and finite element analysis. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Gawandi, A. A.; Gillespie, J. W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Alfredsson, K. S.] Univ Skovde, S-54128 Skovde, Sweden. [Carlsson, L. A.] Florida Atlantic Univ, Dept Mech Engn, Boca Raton, FL 33431 USA. [Bogetti, T. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gawandi, AA (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM Gawandi@udel.edu NR 16 TC 8 Z9 8 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUN PY 2011 VL 93 IS 7 BP 1621 EP 1630 DI 10.1016/j.compstruct.2011.01.015 PG 10 WC Materials Science, Composites SC Materials Science GA 753IA UT WOS:000289764300002 ER PT J AU Little, SF Webster, WM Fisher, DE AF Little, Stephen F. Webster, Wendy M. Fisher, Diana E. TI Monoclonal antibodies directed against protective antigen of Bacillus anthracis enhance lethal toxin activity in vivo SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE monoclonal antibodies; antibody-dependent enhancement; in vivo; anthrax lethal toxin ID DENGUE VIRUS-INFECTION; DEPENDENT ENHANCEMENT; MEDIATED ENHANCEMENT; INHALATIONAL ANTHRAX; NEUTRALIZING EPITOPE; MURINE MACROPHAGES; RECEPTOR-BINDING; EDEMA FACTOR; IMMUNITY; VACCINE AB Protective antigen (PA) from Bacillus anthracis binds to cellular receptors, combines with lethal factor (LF) forming lethal toxin (LeTx), and facilitates the translocation of LF into the cytosol. LeTx is cytotoxic for J774A.1 cells, a murine macrophage cell line, and causes death of Fisher 344 rats when injected intravenously. PA is also the major protective component in anthrax vaccines. Antibody-dependent enhancement has been reported for several viral diseases, a bacterial infection, and for B. anthracis LeTx in vitro cytotoxicity. Further screening of our 73 PA monoclonal antibodies (mAbs) identified a total of 17 PA mAbs that enhanced in vitro cytotoxicity at suboptimal concentrations of LeTx. A competitive binding enzyme-linked immunosorbent assay showed that these 17 PA mAbs identified eight different antigenic regions on PA. Eight of the 17 PA mAbs that enhanced LeTx in vitro cytoxicity were examined for their activity in vivo. Of the eight mAbs that were injected intravenously with a sublethal concentration of LeTx into male Fisher 344 rats, four mAbs enhanced the lethality of LeTx and resulted in the death of animals, whereas control animals did not succumb to intoxication. This is the first demonstration that PA mAbs can enhance LeTx intoxication in vivo. C1 [Little, Stephen F.; Webster, Wendy M.] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Fisher, Diana E.] USA, Biostast Serv Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Little, SF (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM stephen.little@amedd.army.mil FU DTRA [92230]; US Army Medical Research and Materiel Command [02-4-CC-009] FX The authors acknowledge the contribution of M. Williams for technical assistance, S. Guest for growth and maintenance of hybridoma cell lines, and K. Kenyon for excellent editorial assistance. This work was supported by DTRA project no. 92230.; Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the US Army. The research described herein was sponsored by the US Army Medical Research and Materiel Command, Project 02-4-CC-009. NR 60 TC 14 Z9 15 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD JUN PY 2011 VL 62 IS 1 BP 11 EP 22 DI 10.1111/j.1574-695X.2011.00782.x PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 754DM UT WOS:000289832700002 PM 21231965 ER PT J AU Narayanan, A Popova, T Turell, M Kidd, J Chertow, J Popov, SG Bailey, C Kashanchi, F Kehn-Hall, K AF Narayanan, Aarthi Popova, Taissia Turell, Michael Kidd, Jessica Chertow, Jessica Popov, Serguei G. Bailey, Charles Kashanchi, Fatah Kehn-Hall, Kylene TI Alteration in Superoxide Dismutase 1 Causes Oxidative Stress and p38 MAPK Activation Following RVFV Infection SO PLOS ONE LA English DT Article ID RIFT-VALLEY FEVER; AMYOTROPHIC-LATERAL-SCLEROSIS; NONSTRUCTURAL PROTEIN NSS; SIGNALING PATHWAY; INFLUENZA-VIRUS; GREEN TEA; TRANSCRIPTION; DISEASE; CELLS; REPLICATION AB Rift Valley fever (RVF) is a zoonotic disease caused by Rift Valley fever virus (RVFV). RVFV is a category A pathogen that belongs to the genus Phlebovirus, family Bunyaviridae. Understanding early host events to an infectious exposure to RVFV will be of significant use in the development of effective therapeutics that not only control pathogen multiplication, but also contribute to cell survival. In this study, we have carried out infections of human cells with a vaccine strain (MP12) and virulent strain (ZH501) of RVFV and determined host responses to viral infection. We demonstrate that the cellular antioxidant enzyme superoxide dismutase 1 (SOD1) displays altered abundances at early time points following exposure to the virus. We show that the enzyme is down regulated in cases of both a virulent (ZH501) and a vaccine strain (MP12) exposure. Our data demonstrates that the down regulation of SOD1 is likely to be due to post transcriptional processes and may be related to up regulation of TNF alpha following infection. We also provide evidence for extensive oxidative stress in the MP12 infected cells. Concomitantly, there is an increase in the activation of the p38 MAPK stress response, which our earlier published study demonstrated to be an essential cell survival strategy. Our data suggests that the viral anti-apoptotic protein NSm may play a role in the regulation of the cellular p38 MAPK response. Alterations in the host protein SOD1 following RVFV infection appears to be an early event that occurs in multiple cell types. Activation of the cellular stress response p38 MAPK pathway can be observed in all cell types tested. Our data implies that maintaining oxidative homeostasis in the infected cells may play an important role in improving survival of infected cells. C1 [Narayanan, Aarthi; Popova, Taissia; Chertow, Jessica; Popov, Serguei G.; Bailey, Charles; Kashanchi, Fatah; Kehn-Hall, Kylene] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. [Turell, Michael] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Kidd, Jessica] MDA ALS Res Ctr, Neurol Inst, New York, NY USA. RP Narayanan, A (reprint author), George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. EM fkashanc@gmu.edu RI Kehn-Hall, Kylene/I-5752-2013 FU US Department of Energy [DE-SC0001599] FX This work was funded by US Department of Energy grant (DE-SC0001599) to CB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 13 Z9 13 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 31 PY 2011 VL 6 IS 5 AR e20354 DI 10.1371/journal.pone.0020354 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 770OP UT WOS:000291097600051 PM 21655261 ER PT J AU Peterson, MW Fairchild, SZ Otto, TC Mohtashemi, M Cerasoli, DM Chang, WE AF Peterson, Matthew W. Fairchild, Steven Z. Otto, Tamara C. Mohtashemi, Mojdeh Cerasoli, Douglas M. Chang, Wenling E. TI VX Hydrolysis by Human Serum Paraoxonase 1: A Comparison of Experimental and Computational Results SO PLOS ONE LA English DT Article ID TRANSITION-STATE DOCKING; STRUCTURE PREDICTION; ACTIVE-SITE; PON1; LACTONASE; STABILITY; PROGRAMS AB Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has been suggested that increasing HuPON1's organophosphorous hydrolase activity by one or two orders of magnitude would make the enzyme suitable for this purpose. The binding interaction between HuPON1 and VX has recently been modeled, but the mechanism for VX hydrolysis is still unknown. In this study, we created a transition state model for VX hydrolysis (VX(ts)) in water using quantum mechanical/molecular mechanical simulations, and docked the transition state model to 22 experimentally characterized HuPON1 variants using AutoDock Vina. The HuPON1-VX(ts) complexes were grouped by reaction mechanism using a novel clustering procedure. The average Vina interaction energies for different clusters were compared to the experimentally determined activities of HuPON1 variants to determine which computational procedures best predict how well HuPON1 variants will hydrolyze VX. The analysis showed that only conformations which have the attacking hydroxyl group of VX(ts) coordinated by the sidechain oxygen of D269 have a significant correlation with experimental results. The results from this study can be used for further characterization of how HuPON1 hydrolyzes VX and design of HuPON1 variants with increased activity against VX. C1 [Peterson, Matthew W.; Fairchild, Steven Z.; Mohtashemi, Mojdeh; Chang, Wenling E.] Mitre Corp, Bedford, MA 01730 USA. [Peterson, Matthew W.] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA. [Otto, Tamara C.; Cerasoli, Douglas M.] USA, Physiol & Immunol Branch, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Mohtashemi, Mojdeh] MIT Comp Sci & Lab, Cambridge, MA USA. [Chang, Wenling E.] George Mason Univ, Sch Syst Biol, Manassas, VA USA. RP Peterson, MW (reprint author), Mitre Corp, Burlington Rd, Bedford, MA 01730 USA. EM wchang@mitre.org FU Defense Threat Reduction Agency-Joint Science and Technology Office Medical ST Division FX The research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office Medical S&T Division. The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 32 TC 14 Z9 14 U1 2 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 31 PY 2011 VL 6 IS 5 AR e20335 DI 10.1371/journal.pone.0020335 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 770OP UT WOS:000291097600046 PM 21655255 ER PT J AU Chiao, CC Wickiser, JK Allen, JJ Genter, B Hanlon, RT AF Chiao, Chuan-Chin Wickiser, J. Kenneth Allen, Justine J. Genter, Brock Hanlon, Roger T. TI Hyperspectral imaging of cuttlefish camouflage indicates good color match in the eyes of fish predators SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Sepia officinalis; skin coloration; defense; predator-prey; visual perception ID CEPHALOPOD DYNAMIC CAMOUFLAGE; SEPIA-OFFICINALIS; NATURAL SCENES; OBJECTIVE ASSESSMENT; ANIMAL COLORATION; BODY PATTERNS; VISION; STATISTICS; PERCEPTION; SPIDERS AB Camouflage is a widespread phenomenon throughout nature and an important antipredator tactic in natural selection. Many visual predators have keen color perception, and thus camouflage patterns should provide some degree of color matching in addition to other visual factors such as pattern, contrast, and texture. Quantifying camouflage effectiveness in the eyes of the predator is a challenge from the perspectives of both biology and optical imaging technology. Here we take advantage of hyperspectral imaging (HSI), which records full-spectrum light data, to simultaneously visualize color match and pattern match in the spectral and the spatial domains, respectively. Cuttlefish can dynamically camouflage themselves on any natural substrate and, despite their colorblindness, produce body patterns that appear to have high-fidelity color matches to the substrate when viewed directly by humans or with RGB images. Live camouflaged cuttlefish on natural backgrounds were imaged using HSI, and subsequent spectral analysis revealed that most reflectance spectra of individual cuttlefish and substrates were similar, rendering the color match possible. Modeling color vision of potential di- and trichromatic fish predators of cuttlefish corroborated the spectral match analysis and demonstrated that camouflaged cuttlefish show good color match as well as pattern match in the eyes of fish predators. These findings (i) indicate the strong potential of HSI technology to enhance studies of biological coloration and (ii) provide supporting evidence that cuttlefish can produce color-coordinated camouflage on natural substrates despite lacking color vision. C1 [Chiao, Chuan-Chin; Allen, Justine J.; Hanlon, Roger T.] Marine Biol Lab, Woods Hole, MA 02543 USA. [Chiao, Chuan-Chin] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30013, Taiwan. [Wickiser, J. Kenneth; Genter, Brock] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Allen, Justine J.] Brown Univ, Dept Neurosci, Providence, RI 02912 USA. [Hanlon, Roger T.] Brown Univ, Dept Ecol & Evolutionary Biol, Providence, RI 02912 USA. RP Chiao, CC (reprint author), Marine Biol Lab, Woods Hole, MA 02543 USA. EM ccchiao@life.nthu.edu.tw RI Hanlon, Roger/Q-8687-2016; OI Hanlon, Roger/0000-0003-0004-5674; Allen, Justine/0000-0001-9974-4226 FU National Science Council of Taiwan [NSC-98-2628-B-007-001-MY3]; Network Science Center at West Point; Army Research Office; National Defense Science and Engineering Graduate Fellowship; Office of Naval [N000140610202] FX We thank LTC John Ingram for assistance at the beginning of the project and the Photonics Research Center at West Point for the support and use of the HSI equipment. Lydia Mathger provided helpful suggestions and we appreciate husbandry assistance from various laboratory members at the Marine Biological Laboratory. We acknowledge financial support from the National Science Council of Taiwan (NSC-98-2628-B-007-001-MY3) (to C.-C.C.), from the Network Science Center at West Point and the Army Research Office (J.K.W.), from the National Defense Science and Engineering Graduate Fellowship (J.J.A.), and from Office of Naval Research Grant N000140610202 (to R.H.). NR 58 TC 34 Z9 35 U1 6 U2 83 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 31 PY 2011 VL 108 IS 22 BP 9148 EP 9153 DI 10.1073/pnas.1019090108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 770RM UT WOS:000291106200050 PM 21576487 ER PT J AU Cornwell, CF Welch, CR AF Cornwell, Charles F. Welch, Charles R. TI Very-high-strength (60-GPa) carbon nanotube fiber design based on molecular dynamics simulations SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MECHANICAL-PROPERTIES; YOUNGS MODULUS; ROPES; BUNDLES; STRAIN; YARNS; LOAD; SPUN AB The mechanical properties of carbon nanotubes such as low density, high stiffness, and exceptional strength make them ideal candidates for reinforcement material in a wide range of high-performance composites. Molecular dynamics simulations are used to predict the tensile response of fibers composed of aligned carbon nanotubes with intermolecular bonds of interstitial carbon atoms. The effects of bond density and carbon nanotube length distribution on fiber strength and stiffness are investigated. The interstitial carbon bonds significantly increase load transfer between the carbon nanotubes over that obtained with van der Waals forces. The simulation results indicate that fibers with tensile strengths to 60 GPa could be produced by employing interstitial cross-link atoms. The elastic modulus of the fibers is also increased by the bonds. [doi:10.1063/1.3594197] C1 [Cornwell, Charles F.; Welch, Charles R.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cornwell, CF (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Charles.F.Cornwell@usace.army.mil; Charles.R.Welch@usace.army.mil FU U.S. Army Engineer Research and Development Center; HPC FX This study gratefully acknowledges funding support from the U.S. Army Engineer Research and Development Center research program "Molecular-Designed Carbon Nanotube Filaments, Membranes, and Coatings" and the HPC Challenge Project "Molecular Dynamics Simulations To Underpin the Design and Development of High-Performance Carbon-Nanotube-Based Filaments, Membranes, and Coatings" and allocation of computer time from the Department of Defense High Performance Computing Modernization Program. NR 43 TC 18 Z9 18 U1 2 U2 30 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAY 28 PY 2011 VL 134 IS 20 AR 204708 DI 10.1063/1.3594197 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 770SD UT WOS:000291107900057 PM 21639468 ER PT J AU Day, RS McDade, KK Chandran, UR Lisovich, A Conrads, TP Hood, BL Kolli, VSK Kirchner, D Litzi, T Maxwell, GL AF Day, Roger S. McDade, Kevin K. Chandran, Uma R. Lisovich, Alex Conrads, Thomas P. Hood, Brian L. Kolli, V. S. Kumar Kirchner, David Litzi, Traci Maxwell, G. Larry TI Identifier mapping performance for integrating transcriptomics and proteomics experimental results SO BMC BIOINFORMATICS LA English DT Article ID DAVID BIOINFORMATICS RESOURCES; MESSENGER-RNA EXPRESSION; LARGE GENE LISTS; ANNOTATION DATABASE; PROTEIN ABUNDANCE; CANCER AB Background: Studies integrating transcriptomic data with proteomic data can illuminate the proteome more clearly than either separately. Integromic studies can deepen understanding of the dynamic complex regulatory relationship between the transcriptome and the proteome. Integrating these data dictates a reliable mapping between the identifier nomenclature resultant from the two high-throughput platforms. However, this kind of analysis is well known to be hampered by lack of standardization of identifier nomenclature among proteins, genes, and microarray probe sets. Therefore data integration may also play a role in critiquing the fallible gene identifications that both platforms emit. Results: We compared three freely available internet-based identifier mapping resources for mapping UniProt accessions (ACCs) to Affymetrix probesets identifications (IDs): DAVID, EnVision, and NetAffx. Liquid chromatography-tandem mass spectrometry analyses of 91 endometrial cancer and 7 noncancer samples generated 11,879 distinct ACCs. For each ACC, we compared the retrieval sets of probeset IDs from each mapping resource. We confirmed a high level of discrepancy among the mapping resources. On the same samples, mRNA expression was available. Therefore, to evaluate the quality of each ACC-to-probeset match, we calculated proteome-transcriptome correlations, and compared the resources presuming that better mapping of identifiers should generate a higher proportion of mapped pairs with strong inter-platform correlations. A mixture model for the correlations fitted well and supported regression analysis, providing a window into the performance of the mapping resources. The resources have added and dropped matches over two years, but their overall performance has not changed. Conclusions: The methods presented here serve to achieve concrete context-specific insight, to support well-informed decisions in choosing an ID mapping strategy for "omic" data merging. C1 [Day, Roger S.; McDade, Kevin K.; Chandran, Uma R.; Lisovich, Alex] Univ Pittsburgh, Sch Med, Dept Biomed Informat, Pittsburgh, PA 15261 USA. [Day, Roger S.] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15260 USA. [Conrads, Thomas P.; Hood, Brian L.; Maxwell, G. Larry] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Falls Church, VA 22042 USA. [Kolli, V. S. Kumar; Kirchner, David] Windber Res Inst, Windber, PA 15963 USA. [Litzi, Traci; Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Day, RS (reprint author), Univ Pittsburgh, Sch Med, Dept Biomed Informat, Pittsburgh, PA 15261 USA. EM day01@pitt.edu OI McDade, Kevin/0000-0002-7754-508X FU Dept. of Defense [W81XWH-05-2-0005]; Gynecologic Cancer Center (GCC) [W81XWH-09-2-0051]; [NLMT15LM007059] FX KKM is supported by NLMT15LM007059. The other authors are supported by: USAMRAA Prim Award TATRC/Dept. of Defense, Gynecological Diseases Program (GDP) Grant Number W81XWH-05-2-0005, Gynecologic Cancer Center (GCC) Grant No. W81XWH-09-2-0051. Thanks go to Nova Smith, who assisted in preparation of this manuscript. NR 23 TC 14 Z9 14 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD MAY 27 PY 2011 VL 12 AR 213 DI 10.1186/1471-2105-12-213 PG 13 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 784CD UT WOS:000292130300001 PM 21619611 ER PT J AU Lentine, KL Villines, TC Xiao, HL Schnitzler, MA Brennan, DC Abbott, KC Hauptman, PJ AF Lentine, Krista L. Villines, Todd C. Xiao, Huiling Schnitzler, Mark A. Brennan, Daniel C. Abbott, Kevin C. Hauptman, Paul J. TI Cardioprotective Medication Use After Acute Myocardial Infarction in Kidney Transplant Recipients SO TRANSPLANTATION LA English DT Article DE Billing claims; Kidney transplantation; Myocardial infarction; Prescription drugs; Registries ID ACUTE CORONARY SYNDROMES; RENAL-FUNCTION; DRUG EXPOSURE; DISEASE; OUTCOMES; GUIDELINES; SYSTEM; RECORDS; EVENTS; CLAIMS AB Background. Limited data are available on the use of potentially cardioprotective medications among U.S. kidney transplant recipients. Methods. We constructed a database wherein Organ Procurement and Transplant Network identifiers for kidney transplant recipients were linked to billing records of a private health insurer (2003-2006 claims). Transplant recipients and general beneficiaries with acute myocardial infarction (AMI) events were identified by diagnosis codes. The healthcare process measures of interest comprised prescription fills for beta-blockers, antiplatelet drugs, angiotensin-converting enzyme inhibitors/angiotensin-2 receptor blockers, and beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) within 60 days after AMI. Medication use was compared in transplant and general patients by multivariable regression and by one-to-one matching for demographic and clinical factors including comorbidities and revascularization status. Results. We identified 192 kidney transplant recipients and 52,021 general patients who survived with insurance benefits more than or equal to 60 days after AMI diagnosis. In multiple logistic regression, transplant status was independently associated with increased likelihood of beta-blocker (adjusted odds ratio, 2.50; 95% confidence interval, 1.70-3.68; P < 0.0001) and statin (adjusted odds ratio, 1.78; 95% confidence interval, 1.28-2.48; P = 0.0006) use after AMI. Similarly kidney transplant recipients with AMI more commonly received beta-blockers (83.0% vs. 65.9%; P = 0.0001) and statins (72.0% vs. 62.6%; P = 0.04) compared with matched controls. Use of antiplatelet agents and angiotensin-converting enzyme inhibitors/angiotensin-2 receptor blockers did not differ significantly by transplant status. Conclusions. Although kidney transplant status does not seem to be a barrier to medication use after AMI, there may be opportunities for improving cardiovascular risk management in high-risk transplant recipients. Administrative records offer a practical tool for monitoring cardiovascular complications and healthcare delivery not tracked in national registries. C1 [Lentine, Krista L.; Xiao, Huiling; Schnitzler, Mark A.; Hauptman, Paul J.] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Washington, DC 20307 USA. [Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Dept Med, Washington, DC 20307 USA. [Hauptman, Paul J.] St Louis Univ, Sch Med, Div Cardiol, St Louis, MO 63104 USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 4th Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentinek@slu.edu OI Villines, Todd/0000-0003-2674-3702; Abbott, Kevin/0000-0003-2111-7112 FU National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) [K08DK073036, P30DK079333] FX This work was supported by the National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) grant K08DK073036 (K.L.L.) and P30DK079333 (D.C.B., M.A.S.). NR 30 TC 8 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD MAY 27 PY 2011 VL 91 IS 10 BP 1120 EP 1126 DI 10.1097/TP.0b013e31821570c8 PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 758ZP UT WOS:000290208500014 PM 21427631 ER PT J AU Krajacic, MB Peric, M Smith, KS Schonfeld, ZI Ziher, D Fajdetic, A Kujundzic, N Schonfeld, W Landek, G Padovan, J Jelic, D Ager, A Milhous, WK Ellis, W Spaventi, R Ohrt, C AF Krajacic, Mirjana Bukvic Peric, Mihaela Smith, Kirsten S. Schoenfeld, Zrinka Ivezic Ziher, Dinko Fajdetic, Andrea Kujundzic, Nedjeljko Schoenfeld, Wolfgang Landek, Goran Padovan, Jasna Jelic, Dubravko Ager, Arba Milhous, Wilbur K. Ellis, William Spaventi, Radan Ohrt, Colin TI Synthesis, Structure-Activity Relationship, and Antimalarial Activity of Ureas and Thioureas of 15-Membered Azalides SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PLASMODIUM-FALCIPARUM; IN-VITRO; DOUBLE-BLIND; AZITHROMYCIN; MALARIA; PROPHYLAXIS; INVITRO; CHLOROQUINE; RESISTANCE; TRIAL AB Azithromycin, a first member of the azalide family of macrolides, while having substantial antimalarial activity, failed as a single agent for malaria prophylaxis. In this paper we present the first analogue campaign to identify more potent compounds from this class. Ureas and thioureas of 15-membered azalides, N ''-substituted 9a(N'-carbamoyl-beta-aminoethyl), 9a-(N'-thiocarbamoyl-beta-aminoethyl), 9a-[N'-(beta-cyanoethyl)-N'-(carbarrioyl-beta-aminoethyl)], [N'-(beta-cyanoethyl)-N'-(thiocarbamoyl-beta-aminoethyl)], 9a-{N'-[beta-(ethoxycarbonyl)ethyl]-N'-(carbamoyl-beta-aminoethyl)}, and 9a-[N'-(beta-amidoethyl)-N'-(carbamoyl-beta-aminoethyl)] of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A, were synthesized and their biological properties evaluated. The results obtained indicate a substantial improvement of the in vitro activity against P. falciparum (up to 88 times over azithromycin), particularly for compounds containing both sugar; on the macrocyclic ring and aromatic moiety on 9a-position. The improved in vitro activity was not confirmed in the mouse model, likely due to an increase in lipophilicity of these analogues leading to a higher volume of distribution. Overall, with increased in vitro activity, promising PK properties, and modest in vivo efficacy, this series of molecules represents a good starting platform for the design of novel antimalarial azalides. C1 [Krajacic, Mirjana Bukvic; Peric, Mihaela; Schoenfeld, Zrinka Ivezic; Ziher, Dinko; Fajdetic, Andrea; Kujundzic, Nedjeljko; Schoenfeld, Wolfgang; Landek, Goran; Padovan, Jasna; Jelic, Dubravko; Spaventi, Radan] GlaxoSmithKline Res Ctr Zagreb Ltd, Zagreb 10000, Croatia. [Smith, Kirsten S.; Milhous, Wilbur K.; Ellis, William; Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA. [Ager, Arba] Univ Miami, Dept Microbiol & Immunol, Miami, FL 33177 USA. RP Peric, M (reprint author), GlaxoSmithKline Res Ctr Zagreb Ltd, Prilaz Baruna Filipovica 29, Zagreb 10000, Croatia. EM mihaela.peric@mef.hr FU Renata Rupcic with the scale-up synthesis of certain compounds; Military Infectious Diseases Research Program; U.S. Army Medical Research and Material Command FX The authors thank Dr. Lucia Gerena for the hard work with the in vitro susceptibility testing of P. falciparum strains. The authors also acknowledge the support provided by Renata Rupcic with the scale-up synthesis of certain compounds. This study was supported by the Military Infectious Diseases Research Program and U.S. Army Medical Research and Material Command. NR 25 TC 16 Z9 16 U1 0 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY 26 PY 2011 VL 54 IS 10 BP 3595 EP 3605 DI 10.1021/jm2001585 PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 764SB UT WOS:000290651800011 ER PT J AU Galloway, KM Lester, ME Evans, RK AF Galloway, Kathleen M. Lester, Mark E. Evans, Rachel K. TI Clinical utility of tibial motor and sensory nerve conduction studies with motor recording from the flexor hallucis brevis: a methodological and reliability study SO JOURNAL OF FOOT AND ANKLE RESEARCH LA English DT Article ID TARSAL TUNNEL-SYNDROME; LATERAL PLANTAR NERVES; ABDUCTOR HALLUCIS; TEMPERATURE AB Background: Standard tibial motor nerve conduction measures are established with recording from the abductor hallucis. This technique is often technically challenging and clinicians have difficulty interpreting the information particularly in the short segment needed to assess focal tibial nerve entrapment at the medial ankle as occurs in posterior tarsal tunnel syndrome. The flexor hallucis brevis (FHB) has been described as an alternative site for recording tibial nerve function in those with posterior tarsal tunnel syndrome. Normative data has not been established for this technique. This pilot study describes the technique in detail. In addition we provide reference values for medial and lateral plantar orthodromic sensory measures and assessed intrarater reliability for all measures. Methods: Eighty healthy female participants took part, and 39 returned for serial testing at 4 time points. Mean values +/- SD were recorded for nerve conduction measures, and coefficient of variation as well as intraclass correlation coefficients (ICC) were calculated. Results: Motor latency, amplitude and velocity values for the FHB were 4.1 +/- 0.9 msec, 8.0 +/- 3.0 mV and 45.6 +/- 3.4 m/s, respectively. Sensory latencies, amplitudes, and velocities, respectively, were 2.8 +/- 0.3 msec, 26.7 +/- 10.1 mu V, and 41.4 +/- 3.5 m/s for the medial plantar nerve and 3.2 +/- 0.5 msec, 13.3 +/- 4.7 mu V, and 44.3 +/- 4.0 msec for the lateral plantar nerve. All values demonstrated significant ICC values (P <= 0.007). Conclusion: Motor recording from the FHB provides technically clear waveforms that allow for an improved ability to assess tibial nerve function in the short segments used to assess tarsal tunnel syndrome. The reported means will begin to establish normal values for this technique. C1 [Galloway, Kathleen M.; Lester, Mark E.; Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Galloway, Kathleen M.] Oakland Univ, Rochester, MI 48063 USA. RP Galloway, KM (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM kathy.galloway@belmont.edu FU U.S. Army Medical Research; Materiel Command Bone Health and Military Medical Readiness Research Program FX The authors thank Amanda Antezak for her assistance with many aspects of this project, as well as the participants from Oakland University and surrounding areas for their time and dedication. The U.S. Army Medical Research and Materiel Command Bone Health and Military Medical Readiness Research Program supported this research, in part. NR 35 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1757-1146 J9 J FOOT ANKLE RES JI J. Foot Ankle Res. PD MAY 24 PY 2011 VL 4 AR 14 DI 10.1186/1757-1146-4-14 PG 9 WC Orthopedics SC Orthopedics GA 838ZK UT WOS:000296333100001 PM 21609432 ER PT J AU Darling, KA VanLeeuwen, BK Semones, JE Koch, CC Scattergood, RO Kecskes, LJ Mathaudhu, SN AF Darling, K. A. VanLeeuwen, B. K. Semones, J. E. Koch, C. C. Scattergood, R. O. Kecskes, L. J. Mathaudhu, S. N. TI Stabilized nanocrystalline iron-based alloys: Guiding efforts in alloy selection SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Mechanical alloying; Grain growth; Interfaces; Recrystallization and nanostructured materials ID GRAIN-GROWTH; SOLUTE SEGREGATION; THERMAL-STABILITY; DOPANTS; NANOSTRUCTURES; ENERGY AB Using a modified regular solution model for grain boundary solute segregation, the relative thermal stability of a number of Fe-based nanocrystalline binary alloys was predicted with considerable accuracy. It was found that nanocrystalline iron was strongly stabilized by zirconium, moderately stabilized by tantalum, and not significantly stabilized by nickel or chromium. These findings are fully in line with the aforementioned predictions. This success with iron based alloys highlights the utility of this practical approach to selecting stabilizing solutes for nanocrystalline alloys. Published by Elsevier B.V. C1 [Darling, K. A.; Kecskes, L. J.; Mathaudhu, S. N.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [VanLeeuwen, B. K.; Semones, J. E.; Koch, C. C.; Scattergood, R. O.] NC State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Darling, KA (reprint author), USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM kris.darling@arl.army.mil RI Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 24 TC 41 Z9 41 U1 0 U2 32 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAY 24 PY 2011 VL 528 IS 13-14 BP 4365 EP 4371 DI 10.1016/j.msea.2011.02.080 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 756IF UT WOS:000290004200013 ER PT J AU Munro-Leighton, C Adduci, LL Becker, JJ Gagne, MR AF Munro-Leighton, Colleen Adduci, Laura L. Becker, Jennifer J. Gagne, Michel R. TI Oxidative Addition of Secondary C-X Bonds to Palladium(0): A Beneficial Anomeric Acceleration SO ORGANOMETALLICS LA English DT Article ID CATALYZED CROSS-COUPLINGS; NONACTIVATED ALKYL-HALIDES; GRIGNARD-REAGENTS; ELECTROPHILES; BROMIDES; NI; GLYCOSIDES; DERIVATIVES; ACTIVATION; REACTIVITY AB The oxidative addition of secondary electrophiles to Pd(0) is significantly accelerated by anomeric effects. In contrast to cyclohexyl bromide, acetobromo-alpha-D-glucose undergoes invertive oxidative addition to tris(triethylphosphine)palladium(0) to generate a stable, isolable organometallic complex, Pd(PEt(3))(2)(Br)(AcO-beta-glucose), which has been fully characterized but is prone to beta-acetoxy elimination. C1 [Munro-Leighton, Colleen; Adduci, Laura L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU U.S. Department of Energy [FG02-OSER15630]; U.S. Army Research Office, the National Research Council; UNC Institute for the Environment/Progress Energy Foundation FX Support from the U.S. Department of Energy (FG02-OSER15630), the U.S. Army Research Office, the National Research Council (fellowship to C.M.-L.), and the UNC Institute for the Environment/Progress Energy Foundation (fellowship to L.L.A.) is gratefully acknowledged. NR 37 TC 9 Z9 9 U1 0 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0276-7333 J9 ORGANOMETALLICS JI Organometallics PD MAY 23 PY 2011 VL 30 IS 10 BP 2646 EP 2649 DI 10.1021/om200221r PG 4 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 799TA UT WOS:000293307800005 ER PT J AU Miyata, T Harakuni, T Sugawa, H Sattabongkot, J Kato, A Tachibana, M Torii, M Tsuboi, T Arakawa, T AF Miyata, Takeshi Harakuni, Tetsuya Sugawa, Hideki Sattabongkot, Jetsumon Kato, Aki Tachibana, Mayumi Torii, Motomi Tsuboi, Takafumi Arakawa, Takeshi TI Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine (vol 29, pg 2720, 2011) SO VACCINE LA English DT Correction C1 [Miyata, Takeshi; Harakuni, Tetsuya; Sugawa, Hideki; Arakawa, Takeshi] Univ Ryukyus, Mol Microbiol Grp, Dept Trop Infect Dis, Trop Biosphere Res Ctr,COMP, Okinawa 9030213, Japan. [Sugawa, Hideki] AMBiS Corp, Okinawa 9011202, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Kato, Aki; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Dept Mol Parasitol, Grad Sch Med, Toon, Ehime 7910295, Japan. [Arakawa, Takeshi] Univ Ryukyus, Div Host Def & Vaccinol, Grad Sch Med, Okinawa 9030215, Japan. RP Arakawa, T (reprint author), Univ Ryukyus, Mol Microbiol Grp, Dept Trop, Trop Biosphere Res Ctr,COMP, 1 Senbaru, Okinawa 9030213, Japan. EM tarakawa@comb.u-ryukyu.ac.jp NR 1 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 23 PY 2011 VL 29 IS 23 BP 4077 EP 4077 DI 10.1016/j.vaccine.2011.03.070 PG 1 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 774FQ UT WOS:000291371000020 ER PT J AU Wu, N Wang, WH Tian, Y Zou, XT Maffeo, M Niezrecki, C Chen, JL Wang, XW AF Wu, Nan Wang, Wenhui Tian, Ye Zou, Xiaotian Maffeo, Michael Niezrecki, Christopher Chen, Julie Wang, Xingwei TI Low-cost rapid miniature optical pressure sensors for blast wave measurements SO OPTICS EXPRESS LA English DT Article ID TRAUMATIC BRAIN-INJURY; FIBER; SHOCK; DIAPHRAGM AB This paper presents an optical pressure sensor based on a Fabry-Perot (FP) interferometer formed by a 45 degrees angle polished single mode fiber and an external silicon nitride diaphragm. The sensor is comprised of two V-shape grooves with different widths on a silicon chip, a silicon nitride diaphragm released on the surface of the wider V-groove, and a 45 degrees angle polished single mode fiber. The sensor is especially suitable for blast wave measurements: its compact structure ensures a high spatial resolution; its thin diaphragm based design and the optical demodulation scheme allow a fast response to the rapid changing signals experienced during blast events. The sensor shows linearity with the correlation coefficient of 0.9999 as well as a hysteresis of less than 0.3%. The shock tube test demonstrated that the sensor has a rise time of less than 2 mu s from 0 kPa to 140 kPa. (C) 2011 Optical Society of America C1 [Wu, Nan; Wang, Wenhui; Tian, Ye; Zou, Xiaotian; Wang, Xingwei] Univ Massachusetts Lowell, Dept Elect & Comp Engn, Lowell, MA 01854 USA. [Maffeo, Michael] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Niezrecki, Christopher; Chen, Julie] Univ Massachusetts Lowell, Dept Mech Engn, Lowell, MA 01854 USA. RP Wu, N (reprint author), Univ Massachusetts Lowell, Dept Elect & Comp Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM xingwei_wang@uml.edu RI Tian, Ye/C-4662-2013; Tian, Ye/A-1090-2014; Zou, Xiaotian/J-8657-2013 OI Tian, Ye/0000-0002-0785-1145; Tian, Ye/0000-0002-0785-1145; FU Army Research Laboratory [W911NF-07-2-0081] FX The authors are grateful for the collaboration with Natick Soldier Research, Development, and Engineering Center for sharing the shock tube and the reference pressure sensors. The authors also appreciate the Army Research Laboratory for sponsoring this work (Nanomanufacturing of Multifunctional Sensors Ref. Award Number: W911NF-07-2-0081). NR 12 TC 14 Z9 14 U1 2 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 23 PY 2011 VL 19 IS 11 BP 10797 EP 10804 DI 10.1364/OE.19.010797 PG 8 WC Optics SC Optics GA 767JN UT WOS:000290852800076 PM 21643336 ER PT J AU Izvekov, S Swanson, JMJ AF Izvekov, Sergei Swanson, Jessica M. J. TI Using force-matching to reveal essential differences between density functionals in ab initio molecular dynamics simulations SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID GENERALIZED GRADIENT APPROXIMATION; RADIAL-DISTRIBUTION FUNCTIONS; 1ST PRINCIPLES SIMULATIONS; LIQUID WATER; SYSTEMS; TEMPERATURE; SOLVATION; TRANSPORT; ACCURACY; PHASE AB The exchange-correlation (XC) functional and value of the electronic fictitious mass mu can be two major sources of systematic errors in ab initio Car-Parrinello Molecular Dynamics (CPMD) simulations, and have a significant impact on the structural and dynamic properties of condensed-phase systems. In this work, an attempt is made to identify the origin of differences in liquid water properties generated from CPMD simulations run with the BLYP and HCTH/120 XC functionals and two different values of mu (representative of "small" and "large" limits) by analyzing the effective pairwise atom-atom interactions. The force-matching (FM) algorithm is used to map CPMD interactions into non-polarizable, empirical potentials defined by bonded interactions, pairwise short-ranged interactions in numerical form, and Coulombic interactions via atomic partial charges. The effective interaction models are derived for the BLYP XC functional with mu = 340 a.u. and mu = 1100 a.u. (BLYP-340 and BLYP-1100 simulations) and the HCTH/120 XC functional with mu = 340 a.u. (HCTH-340 simulation). The BLYP-340 simulation results in overstructured water with slow dynamics. In contrast, the BLYP-1100 and HCTH-340 simulations both produce radial distribution functions (indicative of structure) that are in reasonably good agreement with experiment. It is shown that the main difference between the BLYP-340 and HCTH-340 effective potentials arises in the short-ranged nonbonded interactions (in hydrogen bonding regions), while the difference between the BLYP-340 and BLYP-1100 interactions is mainly in the long-ranged electrostatic components. Collectively, these results demonstrate how the FM method can be used to further characterize various simulation ensembles (e. g., density-functional theory via CPMD). An analytical representation of each effective interaction water model, which is easy to implement, is presented. c 2011 American Institute of Physics. [doi: 10.1063/1.3591374] C1 [Izvekov, Sergei] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Swanson, Jessica M. J.] Univ Chicago, Computat Inst, Chicago, IL 60637 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov@us.army.mil FU Division of Chemical Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FG02-09ER16055]; DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX The authors are grateful to Gregory Voth, Betsy Rice, Peter Chung, and Sarah Hamdan for helpful discussions. This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. J.M.J.S. acknowledges funding from the Division of Chemical Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy through Grant No. DE-FG02-09ER16055. Computational resources were provided by the ERDC and the NAVY Department of Defense Supercomputing Resource Centers (DSRCs) of the DoD High Performance Computing Modernization Program. NR 53 TC 13 Z9 13 U1 1 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAY 21 PY 2011 VL 134 IS 19 AR 194109 DI 10.1063/1.3591374 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 770SX UT WOS:000291109900011 PM 21599046 ER PT J AU Akkerman, I Bazilevs, Y Kees, CE Farthing, MW AF Akkerman, I. Bazilevs, Y. Kees, C. E. Farthing, M. W. TI Isogeometric analysis of free-surface flow SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Free-surface flow; Level set method; Global mass conservation; Isogeometric analysis; Higher-order methods; Finite elements; Fluids; Residual-based variational multiscale method (RBVMS); Turbulence ID LEVEL SET METHOD; DIRICHLET BOUNDARY-CONDITIONS; FLUID-STRUCTURE INTERACTION; FINITE-ELEMENT SIMULATION; NAVIER-STOKES EQUATIONS; INCOMPRESSIBLE FLOWS; MOVING BOUNDARIES; BLOOD-FLOW; NURBS; COMPUTATION AB This paper presents the first application of isogeometric analysis, a new computational technology built on higher-order and higher-continuity basis functions employed in Computer-Aided Design and computer graphics, to the computation of free-surface phenomena described using the level set approach. The method is based on the variational framework that is suitable for discretization by standard finite elements as well as the basis functions employed in isogeometric analysis. The underlying numerical formulation globally conserves mass and preserves a sharp air-water interface for the entire length of the simulation. The numerical tests indicate that the proposed methodology gives an accurate description of the free-surface behavior in both quasi-steady and dynamic regimes. Furthermore, very good per-degree-of-freedom accuracy is obtained when higher-order and higher-continuity isogeometric discretizations are employed in free-surface computations. (C) 2010 Elsevier Inc. All rights reserved. C1 [Akkerman, I.; Bazilevs, Y.] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92123 USA. [Kees, C. E.; Farthing, M. W.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bazilevs, Y (reprint author), Univ Calif San Diego, Dept Struct Engn, 9500 Gilman Dr, La Jolla, CA 92123 USA. EM iakkerman@ucsd.edu; yuri@ucsd.edu; christopher.e.kees@usace.army.mil; matthew.w.farthing@usace.army.mil RI Akkerman, Ido/H-9957-2012 FU Teragrid; J. Tinsley Oden faculty fellowship program; US Army Corps of Engineers; US Army Engineering Research and Development Center; Coastal and Hydraulics Laboratory (ERDC-CHL); ARO [W911NF-10-1-0247] FX The authors thank Prof. A.L.G.A. Coutinho for his valuable input on the dam break test problem. We also wish to thank the Texas Advanced Computing Center (TACC) at the University of Texas at Austin for providing HPC resources that have contributed to the research results reported within this paper. Support from Teragrid, the J. Tinsley Oden faculty fellowship program, and the Navigation Systems and Military Engineering 6.1 research programs of the US Army Corps of Engineers are gratefully acknowledged. This research has been supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Engineering Research and Development Center, Coastal and Hydraulics Laboratory (ERDC-CHL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ERDC. The corresponding author was supported through ARO Award W911NF-10-1-0247. Permission was granted by the Chief of Engineers to publish this information. NR 44 TC 51 Z9 52 U1 1 U2 18 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD MAY 20 PY 2011 VL 230 IS 11 SI SI BP 4137 EP 4152 DI 10.1016/j.jcp.2010.11.044 PG 16 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 758RW UT WOS:000290185000003 ER PT J AU Marconi, VC Grandits, G Okulicz, JF Wortmann, G Ganesan, A Crum-Cianflone, N Polis, M Landrum, M Dolan, MJ Ahuja, SK Agan, B Kulkarni, H AF Marconi, Vincent C. Grandits, Greg Okulicz, Jason F. Wortmann, Glenn Ganesan, Anuradha Crum-Cianflone, Nancy Polis, Michael Landrum, Michael Dolan, Matthew J. Ahuja, Sunil K. Agan, Brian Kulkarni, Hemant CA Infect Dis Clinical Res Program TI Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS SO PLOS ONE LA English DT Article ID PROTEASE INHIBITOR THERAPY; VIRUS TYPE-1 RNA; TERM-FOLLOW-UP; CELL COUNT; HIV-1-INFECTED PATIENTS; DISEASE PROGRESSION; DRUG-RESISTANCE; INTERMITTENT VIREMIA; PROGNOSTIC MARKERS; CLINICAL-OUTCOMES AB Background: The impact of viral load (VL) decay and cumulative VL on CD4 recovery and AIDS after highly-active antiretroviral therapy (HAART) is unknown. Methods and Findings: Three virologic kinetic parameters (first year and overall exponential VL decay constants, and first year VL slope) and cumulative VL during HAART were estimated for 2,278 patients who initiated HAART in the U. S. Military HIV Natural History Study. CD4 and VL trajectories were computed using linear and nonlinear Generalized Estimating Equations models. Multivariate Poisson and linear regression models were used to determine associations of VL parameters with CD4 recovery, adjusted for factors known to correlate with immune recovery. Cumulative VL higher than the sample median was independently associated with an increased risk of AIDS (relative risk 2.38, 95% confidence interval 1.56-3.62, p < 0.001). Among patients with VL suppression, first year VL decay and slope were independent predictors of early CD4 recovery (p = 0.001) and overall gain (p < 0.05). Despite VL suppression, those with slow decay during the first year of HAART as well as during the entire therapy period (overall), in general, gained less CD4 cells compared to the other subjects (133 vs. 195.4 cells/mu L; p = 0.001) even after adjusting for potential confounders. Conclusions: In a cohort with free access to healthcare, independent of established predictors of AIDS and CD4 recovery during HAART, cumulative VL and virologic decay patterns were associated with AIDS and distinct aspects of CD4 reconstitution. C1 [Marconi, Vincent C.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA. [Marconi, Vincent C.; Grandits, Greg; Okulicz, Jason F.; Wortmann, Glenn; Ganesan, Anuradha; Crum-Cianflone, Nancy; Polis, Michael; Landrum, Michael; Agan, Brian] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Grandits, Greg] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Okulicz, Jason F.; Landrum, Michael] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Crum-Cianflone, Nancy] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Polis, Michael] NIAID, NIH, Bethesda, MD 20892 USA. [Dolan, Matthew J.] Wilford Hall USAF Med Ctr, Henry M Jackson Fdn, Lackland AFB, TX 78236 USA. [Ahuja, Sunil K.; Kulkarni, Hemant] S Texas Vet Hlth Care Syst, Vet Adm Res Ctr AIDS & HIV 1 Infect, San Antonio, TX USA. [Ahuja, Sunil K.; Kulkarni, Hemant] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. RP Marconi, VC (reprint author), Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA. EM vcmarco@emory.edu; kulkarnih@uthscsa.edu RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program [IDCRP-000-03]; Department of Defense through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System; NIH [R37046326]; VA; Elizabeth Glaser Scientist Award; Burroughs Wellcome Clinical Scientist Award; Doris Duke Distinguished Clinical Scientist Award FX Support for this work (IDCRP-000-03) was provided by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. This work was also supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and a MERIT (R37046326) award from the NIH to SKA. SKA is also supported by a VA MERIT award and is a recipient of the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 24 Z9 24 U1 2 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 20 PY 2011 VL 6 IS 5 AR e17956 DI 10.1371/journal.pone.0017956 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 766OI UT WOS:000290793400001 PM 21625477 ER PT J AU Clifton, GT Sears, AK Patil, R Shumway, NM Carmichael, MG Van Echo, DC Holmes, JP McCall, S Merrill, GA Ponniah, S Peoples, GE Mittendorf, EA AF Clifton, G. T. Sears, A. K. Patil, R. Shumway, N. M. Carmichael, M. G. Van Echo, D. C. Holmes, J. P. McCall, S. Merrill, G. A. Ponniah, S. Peoples, G. E. Mittendorf, E. A. TI Monitoring of circulating tumor cell trends in a prospective, randomized, placebo-controlled HER2/neu peptide vaccine trial SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, San Antonio, TX USA. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. SAMMC, Ft Sam Houston, TX USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Naval Med Ctr San Diego, San Diego, CA USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2011 VL 29 IS 15 SU S MA e11126 PG 1 WC Oncology SC Oncology GA V31JQ UT WOS:000208880303093 PM 28023845 ER PT J AU McLeod, DG Quinn, DI Whitmore, JB Tabesh, M AF McLeod, D. G. Quinn, D. I. Whitmore, J. B. Tabesh, M. TI Sipuleucel-T in African Americans: A subgroup analysis of three phase III sipuleucel-T trials in advanced prostate cancer. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA. Dendreon Corp, Seattle, WA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2011 VL 29 IS 15 SU S MA e15148 PG 1 WC Oncology SC Oncology GA V31JQ UT WOS:000208880304051 PM 28021265 ER PT J AU Oliver, KE Enewold, L Zhu, K Conrads, TP Rose, GS Maxwell, GL Farley, JH AF Oliver, K. E. Enewold, L. Zhu, K. Conrads, T. P. Rose, G. S. Maxwell, G. L. Farley, J. H. TI The presence of racial disparities in histopathologic characteristics of uterine cancer in an equal-access environment. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. US Mil Canc Inst, Washington, DC USA. Womens Hlth Integrated Res Ctr, Annandale, VA USA. USUHS, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2011 VL 29 IS 15 SU S MA 5094 PG 1 WC Oncology SC Oncology GA V31JQ UT WOS:000208880301627 PM 28023632 ER PT J AU Petrovics, G Tan, S Dobi, A Young, D Wang, Z Paetau, A Chen, Y Sreenath, T Brassell, SA Miettinen, M Sesterhenn, I McLeod, DG Srivastava, S AF Petrovics, G. Tan, S. Dobi, A. Young, D. Wang, Z. Paetau, A. Chen, Y. Sreenath, T. Brassell, S. A. Miettinen, M. Sesterhenn, I. McLeod, D. G. Srivastava, S. TI ERG protein expression in prostate and vascular tumors: A potential for ERG-based stratification. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Ctr Prostat Dis Res, Rockville, MD USA. Ctr Prostate Dis Res, Rockville, MD USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, CPDR, Rockville, MD USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2011 VL 29 IS 15 SU S MA e15171 PG 1 WC Oncology SC Oncology GA V31JQ UT WOS:000208880304072 PM 28020916 ER PT J AU Sears, AK Clifton, GT Patil, R Shumway, NM Carmichael, MG Van Echo, DC Holmes, JP Ponniah, S Mittendorf, EA Peoples, GE AF Sears, A. K. Clifton, G. T. Patil, R. Shumway, N. M. Carmichael, M. G. Van Echo, D. C. Holmes, J. P. Ponniah, S. Mittendorf, E. A. Peoples, G. E. TI Sequential administration of trastuzumab and a CD8 T-cell-eliciting HER2/neu peptide vaccine in patients with breast cancer compared to trastuzumab alone. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, San Antonio, TX USA. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. SAMMC, Ft Sam Houston, TX USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Naval Med Ctr San Diego, San Diego, CA USA. USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2011 VL 29 IS 15 SU S MA 564 PG 1 WC Oncology SC Oncology GA V31JQ UT WOS:000208880300067 PM 28021436 ER PT J AU Buda-Okreglak, EM Cordaro, DV AF Buda-Okreglak, Edwarda M. Cordaro, Daniel V. TI Simultaneous chronic myeloid leukemia and chronic lymphocytic leukemia SO BLOOD LA English DT Editorial Material C1 [Buda-Okreglak, Edwarda M.; Cordaro, Daniel V.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Buda-Okreglak, EM (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD MAY 19 PY 2011 VL 117 IS 20 BP 5279 EP 5279 DI 10.1182/blood-2010-08-301788 PG 1 WC Hematology SC Hematology GA 766AR UT WOS:000290751300005 PM 21744517 ER PT J AU Swietnicki, W Carmany, D Retford, M Guelta, M Dorsey, R Bozue, J Lee, MS Olson, MA AF Swietnicki, Wieslaw Carmany, Daniel Retford, Michael Guelta, Mark Dorsey, Russell Bozue, Joel Lee, Michael S. Olson, Mark A. TI Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase SO PLOS ONE LA English DT Article ID ENTEROPATHOGENIC ESCHERICHIA-COLI; STREPTOMYCES SP K01-0509; GRAM-NEGATIVE BACTERIA; BURKHOLDERIA-MALLEI; INFECTIOUS-DISEASES; YOP TRANSLOCATION; FORCE-FIELD; VIRULENCE; PLAGUE; ENTEROCOLITICA AB Yersinia pestis is a Gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans. The pathogen uses a type III secretion system (T3SS) to deliver virulence factors directly from bacterium into host mammalian cells. The system contains a single ATPase, YscN, necessary for delivery of virulence factors. In this work, we show that deletion of the catalytic domain of the yscN gene in Y. pestis CO92 attenuated the strain over three million-fold in the Swiss-Webster mouse model of bubonic plague. The result validates the YscN protein as a therapeutic target for plague. The catalytic domain of the YscN protein was made using recombinant methods and its ATPase activity was characterized in vitro. To identify candidate therapeutics, we tested computationally selected small molecules for inhibition of YscN ATPase activity. The best inhibitors had measured IC(50) values below 20 mu M in an in vitro ATPase assay and were also found to inhibit the homologous BsaS protein from Burkholderia mallei animal-like T3SS at similar concentrations. Moreover, the compounds fully inhibited YopE secretion by attenuated Y. pestis in a bacterial cell culture and mammalian cells at mM concentrations. The data demonstrate the feasibility of targeting and inhibiting a critical protein transport ATPase of a bacterial virulence system. It is likely the same strategy could be applied to many other common human pathogens using type III secretion system, including enteropathogenic E. coli, Shigella flexneri, Salmonella typhimurium, and Burkholderia mallei/pseudomallei species. C1 [Swietnicki, Wieslaw] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Carmany, Daniel] Battelle Eastern Sci & Technol Ctr, Battelle Mem Inst, Aberdeen, MD USA. [Retford, Michael; Guelta, Mark; Dorsey, Russell] Edgewood Chem & Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD USA. [Bozue, Joel] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. [Lee, Michael S.; Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. RP Swietnicki, W (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. EM wieslaw.swietnicki@usuhs.mil FU Defense Threat Reduction Agency [2.10019_08_RD_B] FX This work was supported by the Defense Threat Reduction Agency project 2.10019_08_RD_B (W.S.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 65 TC 18 Z9 18 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 18 PY 2011 VL 6 IS 5 AR e19716 DI 10.1371/journal.pone.0019716 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 765PE UT WOS:000290720200028 PM 21611119 ER PT J AU Gunther, VJ Putnak, R Eckels, KH Mammen, MP Scherer, JM Lyons, A Sztein, MB Sun, W AF Gunther, V. J. Putnak, R. Eckels, K. H. Mammen, M. P. Scherer, J. M. Lyons, A. Sztein, M. B. Sun, W. TI A human challenge model for dengue infection reveals a possible protective role for sustained interferon gamma levels during the acute phase of illness SO VACCINE LA English DT Article DE Dengue; Human challenge; Immune response ID CLINICAL LABORATORY RESPONSES; YELLOW FEVER VIRUSES; T-CELL CLONES; ATTENUATED DENGUE; CYTOKINE PRODUCTION; HEMORRHAGIC-FEVER; DISEASE SEVERITY; RHESUS-MONKEYS; MICE; PATHOGENESIS AB Dengue has recently been defined by the World Health Organization as a major international public health concern. Although several vaccine candidates are in various stages of development, there is no licensed vaccine available to assist in controlling the further spread of this mosquito borne disease. The need for a reliable animal model for dengue disease increases the risk to vaccine developers as they move their vaccine candidates into large-scale phase III testing. In this paper we describe the cellular immune responses observed in a human challenge model for dengue infection; a model that has the potential to provide efficacy data for potential vaccine candidates in a controlled setting. Serum levels of sIL-2R alpha and sTNF-RII were increased in volunteers who developed illness. Supernatants from in vitro stimulated PBMC were tested for cytokines associated with a T(H)1 or T(H)2 T-cell response (IL-2, TNF-alpha, IFN-gamma, IL-4, IL-10, IL-5) and only IFN-gamma was associated with protection against fever and/or viremia. Interestingly, IFN-gamma levels drop to 0 pg/mL for volunteers who develop illness after challenge suggesting that some mechanism of immunosuppression may play a role in dengue illness. The human challenge model provides an opportunity to test potential vaccine candidates for efficacy prior to large-scale phase III testing, and hints at a possible mechanism for immune suppression by dengue. (C) 2011 Published by Elsevier Ltd. C1 [Gunther, V. J.; Putnak, R.; Lyons, A.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Eckels, K. H.] Walter Reed Army Inst Res, Div Regulated Act, Pilot Bioprod Facil, Silver Spring, MD 20910 USA. [Mammen, M. P.] Natl Ctr Med Intelligence, Ft Detrick, MD 21702 USA. [Scherer, J. M.] MEDCOM Surety, Ft Detrick, MD 21702 USA. [Sztein, M. B.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Sztein, M. B.] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA. [Sztein, M. B.] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA. [Sun, W.] CBER, Off Vaccine Res & Review, Div Vaccines & Related Prod Applicat, Rockville, MD 20852 USA. RP Gunther, VJ (reprint author), Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. EM v_gunther@yahoo.com RI Lyons, Arthur/B-8923-2011 NR 58 TC 54 Z9 54 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 17 PY 2011 VL 29 IS 22 BP 3895 EP 3904 DI 10.1016/j.vaccine.2011.03.038 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 774FP UT WOS:000291370900015 PM 21443963 ER PT J AU Danner, R Chaudhari, SN Rosenberger, J Surls, J Richie, TL Brumeanu, TD Casares, S AF Danner, Rebecca Chaudhari, Snehal N. Rosenberger, John Surls, Jacqueline Richie, Thomas L. Brumeanu, Teodor-Doru Casares, Sofia TI Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells SO PLOS ONE LA English DT Article ID HUMAN IMMUNE-SYSTEM; SEVERE COMBINED IMMUNODEFICIENCY; SCID IL2R-GAMMA(NULL) MICE; FLOW-CYTOMETRIC ANALYSIS; ANTIGEN PRESENTATION; MONOCLONAL-ANTIBODY; DENDRITIC CELLS; HIV-INFECTION; HOST-DISEASE; BONE-MARROW AB Background: Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials. However, current humanized mouse models show sub-optimal human T cell reconstitution and limited ability to support immunoglobulin class switching by human B cells. This limitation has been attributed to the lack of expression of Human Leukocyte Antigens (HLA) molecules in mouse lymphoid organs. Recently, humanized mice expressing HLA class I molecules have been generated but showed little improvement in human T cell reconstitution and function of T and B cells. Methods: We have generated NOD.Rag1KO.IL2RccKO mice expressing HLA class II (HLA-DR4) molecules under the I-E(d) promoter that were infused as adults with HLA-DR-matched human hematopoietic stem cells (HSC). Littermates lacking expression of HLA-DR4 molecules were used as control. Results: HSC-infused HLA-DR4.NOD.Rag1KO.IL-2RccKO mice developed a very high reconstitution rate (>90%) with long-lived and functional human T and B cells. Unlike previous humanized mouse models reported in the literature and our control mice, the HLA-DR4 expressing mice reconstituted serum levels (natural antibodies) of human IgM, IgG (all four subclasses), IgA, and IgE comparable to humans, and elicited high titers of specific human IgG antibodies upon tetanus toxoid vaccination. Conclusions: Our study demonstrates the critical role of HLA class II molecules for development of functional human T cells able to support immunoglobulin class switching and efficiently respond to vaccination. C1 [Danner, Rebecca; Chaudhari, Snehal N.; Rosenberger, John; Richie, Thomas L.; Casares, Sofia] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. [Surls, Jacqueline; Brumeanu, Teodor-Doru; Casares, Sofia] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Danner, R (reprint author), USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. EM sofia.casares@med.navy.mil OI Richie, Thomas/0000-0002-2946-5456 FU NIH/NIDDK; Juvenile Diabetes Research Foundation; USUHS; USAID; Military Infectious Diseases Research Program; [6000.RAD1.F] FX This work was supported by grants from NIH/NIDDK, Juvenile Diabetes Research Foundation, Military Infectious Diseases Research Program, and USAID to SC and a USUHS grant to TBD. This work was supported by work unit number 6000.RAD1.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 66 Z9 67 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 17 PY 2011 VL 6 IS 5 AR e19826 DI 10.1371/journal.pone.0019826 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 764TX UT WOS:000290657500025 PM 21611197 ER PT J AU Zhang, WD Woolard, DL AF Zhang, W-D Woolard, D. L. TI Far-infrared and terahertz lasing based upon resonant and interband tunneling in InAs/GaSb heterostructures SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRON-TRANSPORT; LASER AB A far-infrared lasing device based upon conduction-band to heavy-hole level interband transitions within a double-barrier broken-gap structure is presented. The upper conduction-band level is populated by resonant tunneling electron injection, and the lower heavy-hole state is depopulated by ultrafast valence-band electron interband tunneling. Significant optical gain exceeding 10(3) cm(-1) for operation in the frequency range 1.9-3.4 THz is predicted from a Kane multiband model based study of an unoptimized structure. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3590273] C1 [Zhang, W-D] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, D. L.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Zhang, WD (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM wzhang5@ncsu.edu NR 11 TC 4 Z9 4 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 16 PY 2011 VL 98 IS 20 AR 203505 DI 10.1063/1.3590273 PG 3 WC Physics, Applied SC Physics GA 766UN UT WOS:000290812100069 ER PT J AU Zhong, XL Yap, YK Pandey, R Karna, SP AF Zhong, Xiaoliang Yap, Yoke Khin Pandey, Ravindra Karna, Shashi P. TI First-principles study of strain-induced modulation of energy gaps of graphene/BN and BN bilayers SO PHYSICAL REVIEW B LA English DT Article ID GRAPHITE AB First-principles calculations based on density functional theory are performed on graphene/BN and BN bilayers to investigate the effect of the strain on their energy gaps. For the graphene/BN bilayer, the bands have characteristic graphenelike features with a small band gap at K. Application of strain modulates the band gap, whose magnitude depends on the strength of interaction between constituent monolayers. For the BN bilayer, on the other hand, a large band gap is predicted, which remains nearly the same for small strains. The increased inhomogeneity in charge density of different carbon sublattices due to a stronger interplanar interaction is the cause of the predicted variation in the band gap with strains applied along the perpendicular direction in the graphene/BN bilayer. C1 [Zhong, Xiaoliang; Yap, Yoke Khin; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Zhong, XL (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.karna@us.army.mil RI Zhong, Xiaoliang/B-2220-2012; OI Yap, Yoke Khin/0000-0002-1224-4120 FU Army Research Laboratory [W911NF-09-2-0026-133417] FX The work at Michigan Technological University was performed under support by the Army Research Laboratory through Contract No. W911NF-09-2-0026-133417. NR 31 TC 59 Z9 59 U1 2 U2 42 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 16 PY 2011 VL 83 IS 19 AR 193403 DI 10.1103/PhysRevB.83.193403 PG 4 WC Physics, Condensed Matter SC Physics GA 765MQ UT WOS:000290711800003 ER PT J AU Roppo, V Raineri, F Raj, R Sagnes, I Trull, J Vilaseca, R Scalora, M Cojocaru, C AF Roppo, V. Raineri, F. Raj, R. Sagnes, I. Trull, J. Vilaseca, R. Scalora, M. Cojocaru, C. TI Enhanced efficiency of the second harmonic inhomogeneous component in an opaque cavity SO OPTICS LETTERS LA English DT Article ID FEMTOSECOND PULSES; OPTICAL HARMONICS; LIGHT WAVES; GENERATION; DISPERSION; BOUNDARY AB In this Letter, we experimentally demonstrate the enhancement of the inhomogeneous second harmonic conversion in the opaque region of a GaAs cavity with efficiencies of the order of 0.1% at 612 nm, using 3 ps pump pulses having peak intensities of the order of 10 MW/cm(2). We show that the conversion efficiency of the inhomogeneous, phase-locked second harmonic component is a quadratic function of the cavity factor Q. (C) 2011 Optical Society of America C1 [Roppo, V.; Trull, J.; Vilaseca, R.; Cojocaru, C.] Univ Politecn Cataluna, Dept Fis & Engn Nucl, Rambla St Nebridi 08222, Terrassa, Spain. [Roppo, V.; Scalora, M.] USA, Charles M Bowden Res Facil, RDECOM, Redstone Arsenal, AL 35803 USA. [Raineri, F.; Raj, R.; Sagnes, I.] Lab Photon & Nanostruct, F-91460 Marcoussis, France. [Raineri, F.] Univ Paris Diderot, F-75205 Paris 13, France. RP Roppo, V (reprint author), Univ Politecn Cataluna, Dept Fis & Engn Nucl, Rambla St Nebridi 08222, Terrassa, Spain. EM vito.roppo@upc.edu RI roppo, vito/D-9639-2012; Trull, Jose/L-9054-2014; Raineri, Fabrice/B-2386-2016; OI roppo, vito/0000-0003-0928-4209; Trull, Jose/0000-0002-5850-088X; Vilaseca, Ramon/0000-0002-3736-5789 FU Spanish Government [FIS2008-06024-C03-02]; Catalan Government [2009 SGR 1168]; Army Research Office [W911NF-10-2-0105] FX This work was partially supported by the Spanish Government (FIS2008-06024-C03-02), the Catalan Government (2009 SGR 1168), and the Army Research Office (W911NF-10-2-0105). The authors thank D. Chouteau for his contributions in sample fabrication. NR 20 TC 4 Z9 4 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 15 PY 2011 VL 36 IS 10 BP 1809 EP 1811 PG 3 WC Optics SC Optics GA 765NW UT WOS:000290716000023 PM 21593898 ER PT J AU Griggs, CS Martin, WA Larson, SL O'Connnor, G Fabian, G Zynda, G Mackie, D AF Griggs, Christopher S. Martin, W. Andy Larson, Steven L. O'Connnor, Greg Fabian, Gene Zynda, Greg Mackie, David TI The effect of phosphate application on the mobility of antimony in firing range soils SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Antimony; Phosphate; Leachate; In situ stabilization ID CONTAMINATED SOIL; SHOOTING RANGES; LEAD; METALS; BEHAVIOR; ELEMENTS; MOBILIZATION; ENVIRONMENT; AMENDMENTS; SPECIATION AB Chemical and biogenic sources of phosphate are commonly accepted in situ treatment methods for immobilization of lead (Pb) in soil. The metalloid antimony (Sb), commonly associated with Pb in the environment, exists as either a neutral species or a negatively charged oxyanion. Antimony is used in the manufacture of bullets as a hardening agent, constituting approximately 3% of the bullet mass. Technological solutions to reduce the migration of metals from small arms firing range (SAFR) soils for environmental compliance purposes must be robust with respect to multi-component systems containing both cationic and anionic contaminants. The effect of varying physico-chemical soil properties on Sb mobility post-firing was assessed in this study for six soil types using common analytical protocols and methods related to regulatory criteria. The sands (SM and SP) demonstrated the greatest Sb solubility in post-firing leachate samples and therefore were selected to evaluate the effects of five commercially available stabilization amendments on Sb mobility. Enhanced Sb leaching was experimentally confirmed in the phosphate-treated soils compared to both the untreated control soil and the sulfur-based amendment, and thus suggests competition for negative sorption sites between Sb and phosphate. However, the 5% Buffer Block (R) calcium phosphate amendment did not exhibit the same enhanced Sb release. This can be attributed to the inclusion of aluminum hydroxide in the amendment composition. Technologies are needed that will adequately immobilize Pb without mobilizing oxyanions such as Sb. Further research will be required to elucidate binding mechanisms and redox conditions that govern the mobility of Sb on SAFRs. Published by Elsevier B.V. C1 [Griggs, Christopher S.; Martin, W. Andy; Larson, Steven L.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Fabian, Gene] USA, Aberdeen Test Ctr, Aberdeen Proving Ground, MD USA. [Zynda, Greg] Booz Allen Hamilton Inc, Belcamp, MD USA. [Mackie, David] AMEC, Somerset, NJ USA. RP Griggs, CS (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM Chris.S.Griggs@usace.army.mil FU DoD Environmental Security Technology Certification Program (ESTCP); US Army Environmental Command (USAEC); US Army Environmental Quality and Installation (EQI) FX This study would not be possible without the support of range personnel that provided the field samples. Analytical support was provided by Ms. Michelle Thompson and internal document review was provided by Dr. Afrachanna Butler and Mr. Roy Wade. The authors also acknowledge the support of the DoD Environmental Security Technology Certification Program (ESTCP), the US Army Environmental Command (USAEC), and the US Army Environmental Quality and Installation (EQI) program for funding various aspects of this research. Citation of trade names in this report does not constitute an official endorsement or approval of the use of such commercial NR 57 TC 24 Z9 24 U1 0 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD MAY 15 PY 2011 VL 409 IS 12 BP 2397 EP 2403 DI 10.1016/j.scitotenv.2011.02.043 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 767BG UT WOS:000290829700008 PM 21440928 ER PT J AU Sparrevik, M Saloranta, T Cornelissen, G Eek, E Fet, AM Breedveld, GD Linkov, I AF Sparrevik, Magnus Saloranta, Tuomo Cornelissen, Gerard Eek, Espen Fet, Annik Magerholm Breedveld, Gijs D. Linkov, Igor TI Use of Life Cycle Assessments To Evaluate the Environmental Footprint of Contaminated Sediment Remediation SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID IMPACT ASSESSMENT; DRILLING DISCHARGES; EXPOSURE; MODEL; OPTIONS; CARBON; SITE; NORMALIZATION; CONSEQUENCES; FATE AB Ecological and human risks often drive the selection of remedial alternatives for contaminated sediments. Traditional human and ecological risk assessment (HERA) includes assessing risk for benthic organisms and aquatic fauna associated with exposure to contaminated sediments before and after remediation as well as risk for human exposure but does not consider the environmental footprint associated with implementing remedial alternatives. Assessment of environmental effects over the whole life cycle (i.e., Life Cycle Assessment, LCA) could complement HERA and help in selecting the most appropriate sediment management alternative. Even though LCA has been developed and applied in multiple environmental management cases, applications to contaminated sediments and marine ecosystems are in general less frequent. This paper implements LCA methodology for the case of the polychlorinated dibenzo-p-dioxins and -furans (PCDD/F)-contaminated Grenland fiord in Norway. LCA was applied to investigate the environmental footprint of different active and passive thin-layer capping alternatives as compared to natural recovery. The results showed that capping was preferable to natural recovery when analysis is limited to effects related to the site contamination. Incorporation of impacts related to the use of resources and energy during the implementation of a thin layer cap increase the environmental footprint by over 1 order of magnitude, making capping inferior to the natural recovery alternative. Use of biomass-derived activated carbon, where carbon dioxide is sequestered during the production process, reduces the overall environmental impact to that of natural recovery. The results from this study show that LCA may be a valuable tool for assessing the environmental footprint of sediment remediation projects and for sustainable sediment management. C1 [Sparrevik, Magnus; Cornelissen, Gerard; Eek, Espen; Breedveld, Gijs D.] Norwegian Geotech Inst, NO-0806 Oslo, Norway. [Sparrevik, Magnus; Fet, Annik Magerholm] Norwegian Univ Technol, Dept Ind Econ & Technol Management, N-7491 Trondheim, Norway. [Saloranta, Tuomo] Norwegian Inst Water Res, NO-0349 Oslo, Norway. [Linkov, Igor] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Sparrevik, M (reprint author), Norwegian Geotech Inst, POB 3930 Ulleval Stad, NO-0806 Oslo, Norway. EM magnus.sparrevik@ngi.no OI Breedveld, Gijs D./0000-0003-2944-840X FU Norwegian Research Council [182720/I40]; U.S. Army Corps of Engineers FX The authors would like to thank the Opticap (www.opticap. no) project and especially Morten Schaanning NIVA for supplying data and valuable information to the study and the Norwegian Research Council for financing the work (project no.: 182720/I40). The last author would like to acknowledge the funding from the Dredging Operation Environmental Research (DOER) program by the U.S. Army Corps of Engineers. Permission was granted by the USACE Chief of Engineers to publish this material. NR 41 TC 39 Z9 41 U1 13 U2 87 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 15 PY 2011 VL 45 IS 10 BP 4235 EP 4241 DI 10.1021/es103925u PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 761UQ UT WOS:000290426900012 PM 21520943 ER PT J AU Ren, XD Chen, JS Li, J Slawson, TR Roth, MJ AF Ren, Xiaodan Chen, Jiun-Shyan Li, Jie Slawson, T. R. Roth, M. J. TI Micro-cracks informed damage models for brittle solids SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Multi-scale; Damage model; Micro-crack; Homogenization; Helmholtz free energy ID KERNEL PARTICLE METHODS; MATHEMATICAL HOMOGENIZATION; DIFFERENTIAL SCHEME; COMPOSITE-MATERIALS; CONCRETE; ENERGY; MODULI AB A class of micro-cracks informed damage models for describing the softening behavior of brittle solids is proposed, in which damage evolution is treated as a consequence of micro-crack propagation. The homogenized stress-strain relation in the cracked microscopic cell defines the degradation tensor, which can be obtained by the equivalence between the averaged strain energy of the microscopic cell and the strain energy density of the homogenized material. This energy equivalence relationship serves as an energy bridging vehicle between the damaged continuum and the cracked microstructure. Several damage evolution equations are obtained by this energy bridging method. The size effect of the micro-cracks informed damage law is characterized through the microscopic cell analysis, and the proper scaling of the characterized damage evolution functions to eliminate mesh dependency in the continuum solution is introduced. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Chen, Jiun-Shyan] Univ Calif Los Angeles, Dept Civil & Environm Engn, Los Angeles, CA 90095 USA. [Ren, Xiaodan; Li, Jie] Tongji Univ, Sch Civil Engn, Shanghai 200092, Peoples R China. [Slawson, T. R.; Roth, M. J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Chen, JS (reprint author), Univ Calif Los Angeles, Dept Civil & Environm Engn, POB 159310, Los Angeles, CA 90095 USA. EM jschen@seas.ucla.edu RI 谢, 毅源/G-7347-2012; Li, Jie/C-4652-2013 OI Li, Jie/0000-0002-4366-7724 FU US Army Engineer Research and Development Center [W912HZ-07-C-0019]; National Science Foundation of China [90715033] FX Financial support from the US Army Engineer Research and Development Center (Grant No. W912HZ-07-C-0019) to UCLA and National Science Foundation of China for key Project (Grant No. 90715033) to Tongji University is gratefully acknowledged. Permission to publish was granted by Director, Geotechnical & Structures Laboratory. NR 33 TC 10 Z9 10 U1 3 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD MAY 15 PY 2011 VL 48 IS 10 BP 1560 EP 1571 DI 10.1016/j.ijsolstr.2011.02.001 PG 12 WC Mechanics SC Mechanics GA 753IT UT WOS:000289766200014 ER PT J AU Vento, TJ Prakash, V Murray, CK Brosch, LC Tchandja, JB Cogburn, C Yun, HC AF Vento, Todd J. Prakash, Vidhya Murray, Clinton K. Brosch, Lorie C. Tchandja, Juste B. Cogburn, Cynthia Yun, Heather C. TI Pneumonia in Military Trainees: A Comparison Study Based on Adenovirus Serotype 14 Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ACUTE RESPIRATORY-DISEASE; COMMUNITY-ACQUIRED PNEUMONIA; ADULTS; OUTBREAK; RECRUITS; ILLNESS; EPIDEMIOLOGY; GUIDELINES; SOCIETY; TYPE-7 AB Methods. Medical records of military trainees hospitalized with pneumonia during an outbreak of Ad-14 infection were reviewed. Clinical, radiographic, and laboratory parameters were compared on the basis of Ad-14 infection. Results. Two hundred thirty-four trainees received a diagnosis of pneumonia, and 83(35%) were hospitalized. Sixty-one percent of patients with pneumonia were Ad-14 positive; 43% of patients with Ad-14 pneumonia were hospitalized (83% of female patients and 40% of male patients; P = .04), compared with 40% of patients with Ad-14 negative cases. Ad-14 infection was associated with higher admission temperature (38.3(o)C [interquartile range, (IQR) 37.7, 39.4] vs 37.3(o)C [IQR (36.7, 38.5)]; P < .01) and lower white blood cell count (8.3 x 1000 cells/mu L [IQR, 5.7, 12.4] vs 13 x 1000 cells/mu L [IQR, 7.5, 12.9]; P = .01), neutrophil count (6.7 x 1000 cells/mu L [IQR, 2.8, 9.7] vs 9.7 x 1000 cells/mu L [IQR, 5.6, 12.1]; P = .02), lymphocyte count (0.9 x 1000 cells/mu L [IQR, 0.8, 1.1] vs 1.3 x 1000 cells/mu L [IQR, 1, 1.9]; P = .001), and platelet count (210 x 1000 cells/mu L [IQR, 145, 285] vs 261 x 1000 cells/mu L [IQR, 238, 343]; P < .01). Ad-14 pneumonia was not associated with specific radiographic findings, pneumonia severity score, intensive care unit admission, longer hospitalization, or 30-day mortality. Conclusions. During an outbreak of Ad-14 infection, Ad-14 infection was not associated with excess overall morbidity or mortality. Ad-14 infection was associated with specific laboratory and clinical parameters and higher hospitalization rates in female trainees. These data provide new insight to the epidemiology of Ad-14 infection. C1 [Vento, Todd J.; Murray, Clinton K.; Yun, Heather C.] Brooke Army Med Ctr, Infect Dis Serv, Dept Med, San Antonio, TX USA. [Prakash, Vidhya] Wright Patterson Med Ctr, Dept Med, Infect Dis Serv, Wright Patterson AFB, OH USA. [Murray, Clinton K.; Yun, Heather C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Vento, TJ (reprint author), USA, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM todd.vento@us.army.mil NR 32 TC 10 Z9 14 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2011 VL 203 IS 10 BP 1388 EP 1395 DI 10.1093/infdis/jir040 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 754FC UT WOS:000289838800006 PM 21502080 ER PT J AU West, BJ West, D AF West, Bruce J. West, Damien TI Are allometry and macroevolution related? SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Allometry; Metabolism; Pareto distribution; Probability calculus ID FOSSIL RECORD; MODEL; EXTINCTIONS; SIMILARITY; EVOLUTION; SIZE AB The allometric relationship between the basal metabolic rate B and total body mass M is B = aM(b), where the allometry coefficient a and the allometry exponent b have been fit to various data sets for over 150 years. The best fit of the allometry exponent to 391 mammalian species is given by Heusner [7] to be midway between the leading theoretical values of 2/3 and 3/4. Most theoretical investigations have focused on determining the proper value of b entailed by an appropriate biological model and with some notable exceptions ignored the allometry coefficient a altogether. Herein, we shift the focus and use the above data to settle on an empirical value of b that gives rise to an allometry coefficient with random variability described by a Pareto distribution. This new perspective suggests an interesting biological interpretation of the statistical fluctuations of the allometry coefficient. The time distribution of the intermittent fluctuations in a are determined to be of the same statistical form as those of speciation found in the punctuated equilibrium theory of macroevolution (Eldredge and Gould [3], Sneppen et al. [5] and Rikvold and Zia [17]). Published by Elsevier B.V. C1 [West, Bruce J.] USA, Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. [West, Damien] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. RP West, BJ (reprint author), USA, Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. EM Bruce.J.West@us.army.mil RI West, Damien/F-8616-2012 OI West, Damien/0000-0002-4970-3968 NR 20 TC 2 Z9 3 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 EI 1873-2119 J9 PHYSICA A JI Physica A PD MAY 15 PY 2011 VL 390 IS 10 BP 1733 EP 1736 DI 10.1016/j.physa.2010.11.031 PG 4 WC Physics, Multidisciplinary SC Physics GA 747QY UT WOS:000289335700003 ER PT J AU Crenshaw, ME Bander, TB AF Crenshaw, Michael E. Bander, Thomas B. TI Energy-momentum tensor for the electromagnetic field in a dielectric SO OPTICS COMMUNICATIONS LA English DT Article ID RADIATION PRESSURE; ELECTRODYNAMICS; CONTROVERSY; MINKOWSKI; FORCES; MATTER; LIGHT; MEDIA; WAVE AB The total momentum of a thermodynamically closed system is unique, as is the total energy. Nevertheless, there is continuing confusion concerning the correct form of the momentum and the energy-momentum tensor for an electromagnetic field interacting with a linear dielectric medium. Rather than construct a total momentum from the Abraham momentum or the Minkowski momentum, we define a thermodynamically closed system consisting of a propagating electromagnetic field and a negligibly reflecting dielectric and we identify the Gordon momentum as the conserved total momentum by the fact that it is invariant in time. In the formalism of classical continuum electrodynamics, the Gordon momentum is therefore the unique representation of the total momentum in terms of the macroscopic electromagnetic fields and the macroscopic refractive index that characterizes the material. We also construct continuity equations for the energy and the Gordon momentum, noting that a time variable transformation is necessary to write the continuity equations in terms of the densities of conserved quantities. Finally, we use the continuity equations and the time-coordinate transformation to construct an array that has the properties of a traceless, symmetric energy-momentum tensor. Published by Elsevier B.V. C1 [Crenshaw, Michael E.; Bander, Thomas B.] USA, RDMR WSS, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, RDMR WSS, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL 35898 USA. EM Michael.Crenshaw@us.army.mil NR 27 TC 8 Z9 8 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAY 15 PY 2011 VL 284 IS 10-11 BP 2460 EP 2465 DI 10.1016/j.optcom.2011.01.055 PG 6 WC Optics SC Optics GA 744XN UT WOS:000289128600009 ER PT J AU Bethell, D Se, Y Lon, C Tyner, S Saunders, D Sriwichai, S Darapiseth, S Teja-Isavadharm, P Khemawoot, P Schaecher, K Ruttvisutinunt, W Lin, J Kuntawungin, W Gosi, P Timmermans, A Smith, B Socheat, D Fukuda, MM AF Bethell, Delia Se, Youry Lon, Chanthap Tyner, Stuart Saunders, David Sriwichai, Sabaithip Darapiseth, Sea Teja-Isavadharm, Paktiya Khemawoot, Phisit Schaecher, Kurt Ruttvisutinunt, Wiriya Lin, Jessica Kuntawungin, Worachet Gosi, Panita Timmermans, Ans Smith, Bryan Socheat, Duong Fukuda, Mark M. TI Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; WESTERN CAMBODIA; PARASITES; THAILAND AB Background: The emergence of artemisinin resistance has raised concerns that the most potent antimalarial drug may be under threat. The currently recommended daily dose of artesunate (AS) is 4 mg/kg, and is administered for 3 days together with a partner antimalarial drug. This study investigated the impact of different AS doses on clinical and parasitological responses in malaria patients from an area of known artemisinin resistance in western Cambodia. Methods: Adult patients with uncomplicated P. falciparum malaria were randomized into one of three 7-day AS monotherapy regimens: 2, 4 or 6 mg/kg/day (total dose 14, 28 and 42 mg/kg). Clinical, parasitological, pharmacokinetic and in vitro drug sensitivity data was collected over a 7-day inpatient period and during weekly follow-up to 42 days. Results: 143 patients were enrolled (n = 75, 40 and 28 to receive AS 2, 4 and 6 mg/kg/day respectively). Cure rates were high in all treatment groups at 42 days despite almost half the patients remaining parasitemic on Day 3. There was no impact of increasing AS dose on median parasite clearance times, median parasite clearance rates or on the proportion of patients remaining parasitemic on Day 3. However at the lowest dose used (2 mg/kg/d) patients with parasitemia > 10,000/mu L had longer median (IQR) parasite clearance times than those with parasitemia < 10,000/mu L (63 (48-75) vs. 84 (66-96) hours, p < 0.0001). 19% of patients in the high-dose arm developed neutropenia (absolute neutrophil count < 1.0 x 10(9)/L) by Day 14 and resulted in the arm being halted early. Conclusion: There is no pharmacodynamic benefit of increasing the daily dose of AS (4mg/kg) currently recommended for short-course combination treatment of uncomplicated malaria, even in regions with emerging artemisinin resistance, as long as the partner drug retains high efficacy. C1 [Bethell, Delia; Se, Youry; Lon, Chanthap; Tyner, Stuart; Saunders, David; Sriwichai, Sabaithip; Teja-Isavadharm, Paktiya; Khemawoot, Phisit; Schaecher, Kurt; Ruttvisutinunt, Wiriya; Lin, Jessica; Kuntawungin, Worachet; Gosi, Panita; Timmermans, Ans; Smith, Bryan; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Darapiseth, Sea; Socheat, Duong] Ctr Parasitol Entomol & Malaria Control, Pnom Penh, Cambodia. RP Bethell, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM delia.bethell@afrims.org RI Valle, Ruben/A-7512-2013 FU Bill and Melinda Gates Foundation through the World Health Organization; U.S. Department of Defense FX This study was funded by a Bill and Melinda Gates Foundation Program Grant through the World Health Organization, and the U.S. Department of Defense Global Emerging Infections System (GEIS) Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 39 Z9 39 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 13 PY 2011 VL 6 IS 5 AR e19283 DI 10.1371/journal.pone.0019283 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 763LP UT WOS:000290558500006 PM 21603629 ER PT J AU Barton, NR Bernier, JV Knap, J Sunwoo, AJ Cerreta, EK Turner, TJ AF Barton, Nathan R. Bernier, Joel V. Knap, Jaroslaw Sunwoo, Anne J. Cerreta, Ellen K. Turner, Todd J. TI A call to arms for task parallelism in multi-scale materials modeling SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE solids; materials science; multiscale; plasticity; parallelization; finite element methods ID SITU ADAPTIVE TABULATION; POLYCRYSTALLINE SOLIDS; COMPONENT ARCHITECTURE; DEFORMATION-BEHAVIOR; CRYSTAL PLASTICITY; STRAIN RATES; SIMULATION; TITANIUM; TEXTURE; ALLOY AB Simulations based on multi-scale material models enabled by adaptive sampling have demonstrated speedup factors exceeding an order of magnitude. The use of these methods in parallel computing is hampered by dynamic load imbalance, with load imbalance measurably reducing the achieved speedup. Here we discuss these issues in the context of task parallelism, showing results achieved to date and discussing possibilities for further improvement. In some cases, the task parallelism methods employed to date are able to restore much of the potential wall-clock speedup. The specific application highlighted here focuses on the connection between microstructure and material performance using a polycrystal plasticity-based multi-scale method. However, the parallel load balancing issues are germane to a broad class of multi-scale problems. Copyright (C) 2011 John Wiley & Sons, Ltd. C1 [Barton, Nathan R.; Bernier, Joel V.; Sunwoo, Anne J.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Knap, Jaroslaw] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Cerreta, Ellen K.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Turner, Todd J.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. RP Barton, NR (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. EM barton22@llnl.gov FU agency of the United States government; U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344 (LLNL-JRNL-426324)] FX This document was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor Lawrence Livermore National Security, LLC, nor any of their employees makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States government or Lawrence Livermore National Security, LLC. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States government or Lawrence Livermore National Security, LLC, and shall not be used for advertising or product endorsement purposes.; This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344 (LLNL-JRNL-426324). We gratefully acknowledge the contributions of the members of the Babel and Co-op teams, the cooperation of the Ale3d development team, the resources provided by Livermore Computing, and DOD support of ongoing research through James Mackiewicz. NR 69 TC 11 Z9 11 U1 1 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD MAY 13 PY 2011 VL 86 IS 6 BP 744 EP 764 DI 10.1002/nme.3071 PG 21 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 748CZ UT WOS:000289368900004 ER PT J AU Mattson, WD Balu, R AF Mattson, William D. Balu, Radhakrishnan TI Shock-induced behavior of cubic gauche polymeric nitrogen SO PHYSICAL REVIEW B LA English DT Article ID HIGH-PRESSURE PHASES; SOLID NITROGEN; VIBRATIONAL DYNAMICS; MOLECULAR NITROGEN; ATOMIC PHASES; AB-INITIO; GPA; N-2; TRANSFORMATION; METASTABILITY AB Quantum-mechanical calculations based on density functional theory are used to study the shock response of the polymeric cubic gauche phase of nitrogen (cg-N), proposed as an alternative energetic ingredient to those used in conventional explosive formulations. The shocked polymeric nitrogen undergoes multiple complex phase transformations and spontaneously forms defects. The occurrence of these dynamic phenomena absorbs the shock energy which subsequently slows the compression wave. Additionally, no reaction occurs immediately behind the shock front; rather reactions result from the unraveling of the material at the free edge of the filament opposite to shock propagation. As the material unravels, numerous polyatomic transients are formed, including five-membered rings and polymeric chains, which subsequently undergo secondary reactions to form the final diatomic products. The speed at which these reactions propagate through the material is much slower than the sound speed, and combined with the slowing compression wave, indicates that the material may not detonate under these conditions. C1 [Mattson, William D.; Balu, Radhakrishnan] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Mattson, WD (reprint author), USA, Res Lab, RDRL WML B, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. FU DOD [C2L]; Research Participation Program for the U.S. Army Research Laboratory FX Calculations were performed using the DOD Supercomputing Resource Centers (DSRCs) located at the U.S. Army Research Laboratory and the Air Force Research Laboratory under the Computing Challenge Project C2L awarded by the DOD High Performance Computing Modernization Program. R.B. acknowledges support from the Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education. The authors wish to thank Betsy Rice for helpful comments and discussions. NR 54 TC 8 Z9 9 U1 2 U2 23 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 11 PY 2011 VL 83 IS 17 AR 174105 DI 10.1103/PhysRevB.83.174105 PG 7 WC Physics, Condensed Matter SC Physics GA 762KV UT WOS:000290477200002 ER PT J AU Leslie, T Whitehouse, CA Yingst, S Baldwin, C Kakar, F Mofleh, J Hami, AS Mustafa, L Omar, F Ayazi, E Rossi, C Noormal, B Ziar, N Kakar, R AF Leslie, T. Whitehouse, C. A. Yingst, S. Baldwin, C. Kakar, F. Mofleh, J. Hami, A. S. Mustafa, L. Omar, F. Ayazi, E. Rossi, C. Noormal, B. Ziar, N. Kakar, R. TI Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Emerging infections; infectious disease epidemiology; laboratory tests; plague; zoonoses ID PLAGUE; ANTIBODIES AB Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment. In late December 2007, an outbreak of acute gastroenteritis occurred in Nimroz Province of southern Afghanistan. Of the 83 probable cases of illness, 17 died (case fatality 20.5%). Being a case was associated with consumption or handling of camel meat (adjusted odds ratio 4.4, 95% confidence interval 2.2-8.8, P<0.001). Molecular testing of patient clinical samples and of tissue from the camel using PCR/electrospray ionization-mass spectrometry revealed DNA signatures consistent with Yersinia pestis. Confirmatory testing using real-time PCR and immunological seroconversion of one of the patients confirmed that the outbreak was caused by plague, with a rare gastrointestinal presentation. The study highlights the challenges of identifying infectious agents in low-resource settings; it is the first reported occurrence of plague in Afghanistan. C1 [Leslie, T.] Univ London London Sch Hyg & Trop Med, Dept Dis Control, London WC1E 7HT, England. [Leslie, T.; Hami, A. S.] Hlth Protect & Res Org, Kabul, Afghanistan. [Whitehouse, C. A.; Yingst, S.; Baldwin, C.; Rossi, C.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kakar, F.; Mofleh, J.; Mustafa, L.; Omar, F.; Ayazi, E.; Noormal, B.; Ziar, N.] Minist Publ Hlth, Kabul, Afghanistan. [Kakar, R.] World Hlth Org, Kabul, Afghanistan. RP Leslie, T (reprint author), Univ London London Sch Hyg & Trop Med, Dept Dis Control, Keppel St, London WC1E 7HT, England. EM toby.leslie@lshtm.ac.uk RI Valle, Ruben/A-7512-2013 FU Defense Threat Reduction Agency, Fort Belvoir, VA; WHO Kabul; United States Naval Medical Research Unit no. 3, Cairo, Egypt FX We thank Tamara Clements for conducting the ELISAs. Laboratory research was funded, in part, by the Defense Threat Reduction Agency, Fort Belvoir, VA. Fieldwork was funded by WHO Kabul and United States Naval Medical Research Unit no. 3, Cairo, Egypt. The opinions, interpretations, conclusions, and recommendation are those of the authors and are not necessarily endorsed by the U.S. Army or any other associated agency. NR 19 TC 10 Z9 10 U1 0 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAY 11 PY 2011 VL 139 IS 5 BP 728 EP 735 DI 10.1017/S0950268810001792 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 757RM UT WOS:000290105400010 PM 20663260 ER PT J AU Valiyaveettil, M Alamneh, Y Rezk, P Perkins, MW Sciuto, AM Doctor, BP Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Rezk, Peter Perkins, Michael W. Sciuto, Alfred M. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs SO TOXICOLOGY LETTERS LA English DT Article DE Catalytic bioscavenger; Paraoxonase 1; Recombinant protein; Trichoplusia ni larvae; Chemical warfare nerve agents ID ORGANOPHOSPHATE TOXICITY; PON1 ACTIVITY; EXPRESSION; FAMILY; PRETREATMENT; ENZYMES; HUMANS; BRAIN; CELLS; MICE AB To explore the efficacy of paraoxonase 1 (PON1) as a catalytic bioscavenger, we evaluated human recombinant PON1 (rePON1) expressed in Trichoplusia ni larvae against sarin and soman toxicity using microinstillation inhalation exposure in guinea pigs. Animals were pretreated intravenously with catalytically active rePON1. followed by exposure to 1.2 X LCt(50) sarin or soman. Administration of 5 units of rePON1 showed mild increase in the blood activity of the enzyme after 30 min, but protected the animals with a significant increase in survival rate along with minimal signs of nerve agent toxicity. Recombinant PON1 pretreated animals exposed to sarin or soman prevented the reduction of blood O(2) saturation and pulse rate observed after nerve agent exposure. In addition, rePON1 pretreated animals showed significantly higher blood PON1, acetylcholinesterase (AChE), and butyrylcholinesterase activity after nerve agent exposure compared to the respective controls without treatments. AChE activity in different brain regions of rePON1 pretreated animals exposed to sarin or soman were also significantly higher than respective controls. The remaining activity of blood PON1, cholinesterases and brain AChE in PON1 pretreated animals after nerve agent exposure correlated with the survival rate. In summary, these data suggest that human rePON1 protects against sarin and soman exposure in guinea pigs. (C) 2011 Elsevier Ireland Ltd. All rights reserved. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Rezk, Peter; Perkins, Michael W.; Sciuto, Alfred M.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Doctor, BP (reprint author), Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM bpdoctor@verizon.net; madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.D0017_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.D0017_08_WR_C. We are really grateful to Robert Balcerzak, Chesapeake PERL (Savage, MD) and Dr. Douglas M. Cerasoli, USAMRICD for kindly providing recombinant PON1. NR 39 TC 14 Z9 14 U1 1 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD MAY 10 PY 2011 VL 202 IS 3 BP 203 EP 208 DI 10.1016/j.toxlet.2011.02.007 PG 6 WC Toxicology SC Toxicology GA 766JO UT WOS:000290778600007 PM 21329748 ER PT J AU Crowe, SR Garman, L Engler, RJM Farris, AD Ballard, JD Harley, JB James, JA AF Crowe, Sherry R. Garman, Lori Engler, Renata J. M. Farris, A. Darise Ballard, Jimmy D. Harley, John B. James, Judith A. TI Anthrax vaccination induced anti-lethal factor IgG: Fine specificity and neutralizing capacity SO VACCINE LA English DT Article DE Bacillus anthracis; Anthrax; Anthrax vaccine adsorbed; Lethal factor; Protective antigen; Correlate of protection ID BACILLUS-ANTHRACIS; PROTECTIVE ANTIGEN; MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSE; INFLUENZA VACCINE; TOXIN CHALLENGE; MEASLES-VACCINE; POLYMORPHISMS; RECEPTORS; CELLS AB The efficacy biomarker of the currently licensed anthrax vaccine (AVA) is based on quantity and neutralizing capacity of anti-protective antigen (anti-PA) antibodies. However, animal studies have demonstrated that antibodies to lethal factor (LF) can provide protection against in vivo bacterial spore challenges. Improved understanding of the fine specificities of humoral immune responses that provide optimum neutralization capacity may enhance the efficacy of future passive immune globulin preparations to treat and prevent inhalation anthrax morbidity and mortality. This study (n = 1000) was designed to identify AVA vaccinated individuals who generate neutralizing antibodies and to determine what specificities correlate with protection. The number of vaccine doses, years post vaccination, and PA titer were associated with in vitro neutralization, reinforcing previous reports. In addition, African American individuals had lower serologic neutralizing activity than European Americans, suggesting a genetic role in the generation of these neutralizing antibodies. Of the vaccinated individuals, only 69(6.9%) had moderate levels of anti-LF IgG compared to 244 (24.4%) with low and 687 (68.7%) with extremely low levels of IgG antibodies to LF. Using overlapping decapeptide analysis, we identified six common LF antigenic regions targeted by those individuals with moderate levels of antibodies to LF and high in vitro toxin neutralizing activity. Affinity purified antibodies directed against antigenic epitopes within the PA binding and ADP-ribotransferase-like domains of LF were able to protect mice against lethal toxin challenge. Findings from these studies have important implications for vaccine design and immunotherapeutic development. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Crowe, Sherry R.; Garman, Lori; Farris, A. Darise; James, Judith A.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Garman, Lori; Farris, A. Darise; Ballard, Jimmy D.; Harley, John B.; James, Judith A.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr VHC Network, Washington, DC 20012 USA. [Harley, John B.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. RP James, JA (reprint author), 825 NE 13th St, Oklahoma City, OK 73104 USA. EM jamesj@omrf.ouhsc.edu FU National Institute of Allergy and Infectious Diseases (NIAID) [U19AI062629]; NCRR [P20RR15577]; OMRF J. Donald Capra Fellowship; OMRF Lou C. Kerr Chair in Biomedical Research; Walter Reed Army Medical Center Vaccine Healthcare Centers Network/Allergy-Immunology Department and Womack Army Medical Center, Fort Bragg Regional VHC FX This work was supported by funds from the National Institute of Allergy and Infectious Diseases (NIAID) through grant U19AI062629 and NCRR grant P20RR15577, OMRF J. Donald Capra Fellowship Support, and the OMRF Lou C. Kerr Chair in Biomedical Research. Local protocol development and management was supported by Walter Reed Army Medical Center Vaccine Healthcare Centers Network/Allergy-Immunology Department and Womack Army Medical Center, Fort Bragg Regional VHC. NR 44 TC 17 Z9 18 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 9 PY 2011 VL 29 IS 20 BP 3670 EP 3678 DI 10.1016/j.vaccine.2011.03.011 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 768ZB UT WOS:000290977700008 PM 21420416 ER PT J AU Rinderspacher, BC Andzelm, JW Rawlett, AM Dougherty, JM Baranoski, M Davis, MC AF Rinderspacher, B. Christopher Andzelm, Jan W. Rawlett, Adam M. Dougherty, Joseph M. Baranoski, MyVan Davis, Matthew C. TI The role of aromatic pi-bridges in push-pull-chromophores on the transparency-hyperpolarizability tradeoff SO CHEMICAL PHYSICS LETTERS LA English DT Article ID NONLINEAR-OPTICAL CHROMOPHORES; QUANTUM-CHEMICAL CALCULATIONS; DISPERSION COEFFICIENTS; ELECTROOPTIC ACTIVITY; ENERGIES; EXCHANGE; ACCEPTOR; DESIGN; POLARIZABILITIES; APPROXIMATION AB We present electronic structure calculations of the ultraviolet/visible (UV-Vis) spectra as well as hyperpolarizabilities (HP) of push-pull chromophores based on a donor-aromatic bridge-acceptor framework. As expected, both the color of the chromophores and the static hyperpolarizability are sensitive functions of modifications of the conjugated framework. Effects can be rationalized by determining zwitter-ionic mesomers of the bridge that can be stabilized by the donor or acceptor. The choice of bridge coupled with the substitution pattern on the ring allows targeting specific spectral features (absorption or transparency windows). Exceptionally large hyperpolarizabilities were found for the cyclopentadieno[1,2]-benz[4,5-b]cycloheptatriene bridge. Published by Elsevier B.V. C1 [Rinderspacher, B. Christopher] USA, Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. USN, Warfare Ctr, Chem & Mat Div, Michelson Lab, China Lake, CA 93555 USA. RP Rinderspacher, BC (reprint author), USA, Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. EM berend.rinderspacher@arl.army.mil NR 42 TC 5 Z9 5 U1 1 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD MAY 9 PY 2011 VL 507 IS 4-6 BP 221 EP 225 DI 10.1016/j.cplett.2011.03.038 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 756NF UT WOS:000290018500003 ER PT J AU Hensley, LE Smith, MA Geisbert, JB Fritz, EA Daddario-DiCaprio, KM Larsen, T Geisbert, TW AF Hensley, Lisa E. Smith, Mark A. Geisbert, Joan B. Fritz, Elizabeth A. Daddario-DiCaprio, Kathleen M. Larsen, Tom Geisbert, Thomas W. TI Pathogenesis of lassa fever in cynomolgus macaques SO VIROLOGY JOURNAL LA English DT Article ID CLOSELY RELATED ARENAVIRUS; EBOLA HEMORRHAGIC-FEVER; VIRUS-INFECTION; RHESUS-MONKEYS; DENDRITIC CELLS; SIERRA-LEONE; GUINEA-PIGS; PATHOLOGY; RIBAVIRIN; ENCEPHALOPATHY AB Background: Lassa virus (LASV) infection causes an acute and sometimes fatal hemorrhagic disease in humans and nonhuman primates; however, little is known about the development of Lassa fever. Here, we performed a pilot study to begin to understand the progression of LASV infection in nonhuman primates. Methods: Six cynomolgus monkeys were experimentally infected with LASV. Tissues from three animals were examined at an early-to mid-stage of disease and compared with tissues from three animals collected at terminal stages of disease. Results: Dendritic cells were identified as a prominent target of LASV infection in a variety of tissues in all animals at day 7 while Kupffer cells, hepatocytes, adrenal cortical cells, and endothelial cells were more frequently infected with LASV in tissues of terminal animals (days 13.5-17). Meningoencephalitis and neuronal necrosis were noteworthy findings in terminal animals. Evidence of coagulopathy was noted; however, the degree of fibrin deposition in tissues was less prominent than has been reported in other viral hemorrhagic fevers. Conclusion: The sequence of pathogenic events identified in this study begins to shed light on the development of disease processes during Lassa fever and also may provide new targets for rational prophylactic and chemotherapeutic interventions. C1 [Geisbert, Joan B.; Fritz, Elizabeth A.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Hensley, Lisa E.; Daddario-DiCaprio, Kathleen M.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Smith, Mark A.; Larsen, Tom] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Geisbert, Joan B.; Fritz, Elizabeth A.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX USA. [Geisbert, Joan B.; Fritz, Elizabeth A.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX USA. RP Geisbert, TW (reprint author), Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. EM tom.geisbert@utmb.edu FU Defense Threat Reduction Agency FX The authors thank Jeff Brubaker, Neil Davis, and Chris Mech for their expert technical assistance. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the University of Texas Medical Branch at Galveston. Work on Lassa virus was in part funded by the Defense Threat Reduction Agency. NR 49 TC 39 Z9 39 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAY 6 PY 2011 VL 8 AR 205 DI 10.1186/1743-422X-8-205 PG 15 WC Virology SC Virology GA 770QH UT WOS:000291103100001 PM 21548931 ER PT J AU Miller, EH Harrison, JS Radoshitzky, SR Higgins, CD Chi, XL Dong, L Kuhn, JH Bavari, S Lai, JR Chandran, K AF Miller, Emily Happy Harrison, Joseph S. Radoshitzky, Sheli R. Higgins, Chelsea D. Chi, Xiaoli Dong, Lian Kuhn, Jens H. Bavari, Sina Lai, Jonathan R. Chandran, Kartik TI Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID VIRAL MEMBRANE-FUSION; HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN; RECEPTOR-BINDING; AVIAN-SARCOMA; COILED-COIL; TYPE-1 GP41; INFECTION; MECHANISMS; PROTEINS AB Ebola virus (EboV) and Marburg virus (MarV) (filoviruses) are the causative agents of severe hemorrhagic fever. Infection begins with uptake of particles into cellular endosomes, where the viral envelope glycoprotein (GP) catalyzes fusion between the viral and host cell membranes. This fusion event is thought to involve conformational rearrangements of the transmembrane subunit (GP2) of the envelope spike that ultimately result in formation of a six-helix bundle by the N- and C-terminal heptad repeat (NHR and CHR, respectively) regions of GP2. Infection by other viruses employing similar viral entry mechanisms (such as HIV-1 and severe acute respiratory syndrome coronavirus) can be inhibited with synthetic peptides corresponding to the native CHR sequence ("C-peptides"). However, previously reported EboV C-peptides have shown weak or insignificant antiviral activity. To determine whether the activity of a C-peptide could be improved by increasing its intracellular concentration, we prepared an EboV C-peptide conjugated to the arginine-rich sequence from HIV-1 Tat, which is known to accumulate in endosomes. We found that this peptide specifically inhibited viral entry mediated by filovirus GP proteins and infection by authentic filoviruses. We determined that antiviral activity was dependent on both the Tat sequence and the native EboV CHR sequence. Mechanistic studies suggested that the peptide acts by blocking a membrane fusion intermediate. C1 [Harrison, Joseph S.; Higgins, Chelsea D.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. [Miller, Emily Happy; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Radoshitzky, Sheli R.; Chi, Xiaoli; Dong, Lian; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Kuhn, Jens H.] Tunnell Consulting Inc, King Of Prussia, PA 19406 USA. RP Lai, JR (reprint author), Albert Einstein Coll Med, Dept Biochem, 1300 Morris Pk Ave, Bronx, NY 10461 USA. EM jon.lai@einstein.yu.edu; kartik.chandran@einstein.yu.edu RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU National Institutes of Health [R01 AI088027, R01 AI090249]; Albert Einstein College of Medicine; Arnold and Mabel Beckman Foundation; Joint Science and Technology Office Transformational Medical Technologies [TMTI0048_09_RD_T]; Defense Threat Reduction Agency [4.10022_08_RD_B]; NIAID [HHSN272200200016I] FX This work was supported, in whole or in part, by National Institutes of Health Grants R01 AI088027 (to K. C.) and R01 AI090249 (to J. R. L.). This work was also supported by the Albert Einstein College of Medicine, the Arnold and Mabel Beckman Foundation Young Investigators Program (to J. R. L.), and Joint Science and Technology Office Transformational Medical Technologies Proposal TMTI0048_09_RD_T and Defense Threat Reduction Agency Proposal 4.10022_08_RD_B (to S. B.). J. H. K. performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200200016I. NR 48 TC 27 Z9 30 U1 1 U2 23 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 6 PY 2011 VL 286 IS 18 DI 10.1074/jbc.M110.207084 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 756ON UT WOS:000290022800026 PM 21454542 ER PT J AU Andrews, RS Becker, JJ Gagne, MR AF Andrews, R. Stephen Becker, Jennifer J. Gagne, Michel R. TI Investigating the Rate of Photoreductive Glucosyl Radical Generation SO ORGANIC LETTERS LA English DT Article ID BACK ELECTRON-TRANSFER; VISIBLE-LIGHT PHOTOCATALYSIS; TRANSITION-METAL-COMPLEXES; EXCITED-STATE; RUTHENIUM(II) COMPLEXES; AROMATIC-AMINES; CATALYSIS; ORGANOCATALYSIS; ALDEHYDES; ENERGY AB The photoreduction of glucosyl halides to generate glucosyl radicals has been investigated to probe the nature of the photoredox cycle. Amine (the reductant) and catalyst concentration affect the reaction rate at low concentrations but exhibit saturation at higher concentrations. Water and hydrophobic catalysts were found to significantly increase the conversion efficiency. C1 [Andrews, R. Stephen; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU Army Research Office; Department of Energy [DE-FG02-05ER15630] FX We thank Stephanie Kramer (UNC-CH) for her contribution to initial investigations. J.J.B. thanks the Army Research Office for Staff Research Funding, and M.R.G. thanks the Department of Energy (DE-FG02-05ER15630) for their support. NR 33 TC 54 Z9 54 U1 2 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD MAY 6 PY 2011 VL 13 IS 9 BP 2406 EP 2409 DI 10.1021/ol200644w PG 4 WC Chemistry, Organic SC Chemistry GA 755SM UT WOS:000289956700068 PM 21473567 ER PT J AU Guo, JS Li, HX He, H Chu, D Chen, RR AF Guo, Junsong Li, Haixia He, Hui Chu, Deryn Chen, Rongrong TI CoPc- and CoPcF16-Modified Ag Nanoparticles as Novel Catalysts with Tunable Oxygen Reduction Activity in Alkaline Media SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SIZE-DEPENDENT ACTIVITY; COBALT PHTHALOCYANINE; CARBON NANOTUBES; SODIUM-HYDROXIDE; MANGANESE OXIDE; ELECTROREDUCTION; SURFACE; NANOSTRUCTURES; PORPHYRINS; GOLD AB A new class of non-Pt "hybrid" catalysts is reported that is intended as a lower cost alternative that meets the performance and durability requirements of the oxygen cathode in fuel cells with alkaline electrolytes. These novel hybrid catalysts are cobalt (Co) phthalocyanine on silver (Ag) nanoparticles on a carbon (C) support. For O-2 reduction, a catalyst with cobalt phthalocyanine (Copc) on Ag nanoparticles on carbon (CoPc@Ag/C) or the fully fluorinated cobalt phthalocyanine (CoPcF16) on Ag nanoparticles on carbon (CoPcF16@Ag/C) showed lower overpotentials and higher rate constants at a given potential than did CoPc and CoPcF16 on carbon (CoPc/C and CoPcF16/C) and Ag nanoparticles on carbon (Ag/C). The oxygen reduction reaction (ORR) activity of the cobalt-phthalocyanine-modified Ag nanocatalysts is tuned by adjusting the composition of the metalated phthalocyanine molecules adsorbed on Ag. X-ray photoelectron spectroscopy (XPS) and electrochemical characterizations indicate that the ORR on these new catalysts occurs almost entirely by a 4-electron pathway and shows SO mV lower overpotential in the half-wave potential for CoPc@Ag/C and 82 mV for CoPcF16@Ag/C as compared to that found when using Ag/C as the catalyst. The current densities are higher and Tafel slopes are lower for ORB. on CoPc@Ag/C and CoPcF16@Ag/C than on Ag/C catalysts in the high overpotential region. This indicates higher rate constants at any given potential are obtained with CoPc@Ag/C and CoPcF16@Ag/C than with Ag/C as the catalyst. C1 [Guo, Junsong; Li, Haixia; He, Hui; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu RI dong, guofa/D-5248-2011; li, Haixia/B-9937-2012 FU U.S. Army Research Lab [W911NF-07-2-0036] FX This work was supported by the U.S. Army Research Lab (Grant No. W911NF-07-2-0036). Dr. Guofeng Wang supervised Dr. H. He to conduct DFT simulations of CoPc and CoPcF16. The detailed DFT results will be reported soon. NR 47 TC 25 Z9 25 U1 5 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAY 5 PY 2011 VL 115 IS 17 BP 8494 EP 8502 DI 10.1021/jp112197f PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 754AU UT WOS:000289824200006 ER PT J AU Lambrechts, L Paaijmans, KP Fansiri, T Carrington, LB Kramer, LD Thomas, MB Scott, TW AF Lambrechts, Louis Paaijmans, Krijn P. Fansiri, Thanyalak Carrington, Lauren B. Kramer, Laura D. Thomas, Matthew B. Scott, Thomas W. TI Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE arbovirus; climate; vectorial capacity ID WESTERN EQUINE ENCEPHALOMYELITIS; CULEX-TARSALIS DIPTERA; VECTOR-BORNE DISEASES; CLIMATE-CHANGE; ENVIRONMENTAL-TEMPERATURE; MALARIA TRANSMISSION; EXTRINSIC INCUBATION; INFECTIOUS-DISEASES; ENCEPHALITIS-VIRUS; KAMPHAENG PHET AB Most studies on the ability of insect populations to transmit pathogens consider only constant temperatures and do not account for realistic daily temperature fluctuations that can impact vector-pathogen interactions. Here, we show that diurnal temperature range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti. In two independent experiments using different DENV serotypes, mosquitoes were less susceptible to virus infection and died faster under larger DTR around the same mean temperature. Large DTR (20 degrees C) decreased the probability of midgut infection, but not duration of the virus extrinsic incubation period (EIP), compared with moderate DTR (10 degrees C) or constant temperature. A thermodynamic model predicted that at mean temperatures < 18 degrees C, DENV transmission increases as DTR increases, whereas at mean temperatures > 18 degrees C, larger DTR reduces DENV transmission. The negative impact of DTR on Ae. aegypti survival indicates that large temperature fluctuations will reduce the probability of vector survival through EIP and expectation of infectious life. Seasonal variation in the amplitude of daily temperature fluctuations helps to explain seasonal forcing of DENV transmission at locations where average temperature does not vary seasonally and mosquito abundance is not associated with dengue incidence. Mosquitoes lived longer and were more likely to become infected under moderate temperature fluctuations, which is typical of the high DENV transmission season than under large temperature fluctuations, which is typical of the low DENV transmission season. Our findings reveal the importance of considering short-term temperature variations when studying DENV transmission dynamics. C1 [Lambrechts, Louis; Fansiri, Thanyalak] Inst Pasteur, Dept Virol, F-75724 Paris 15, France. [Paaijmans, Krijn P.; Thomas, Matthew B.] Penn State Univ, Dept Entomol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA. [Fansiri, Thanyalak] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Carrington, Lauren B.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Kramer, Laura D.] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY 12159 USA. [Kramer, Laura D.] SUNY Albany, Sch Publ Hlth, Albany, NY 12237 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Lambrechts, L (reprint author), Inst Pasteur, Dept Virol, F-75724 Paris 15, France. EM louis.lambrechts@pasteur.fr RI Lambrechts, Louis/A-2057-2010; Carrington, Lauren/B-8269-2013; OI Lambrechts, Louis/0000-0001-5958-2138; Carrington, Lauren Bree/0000-0001-9273-7912 FU European Commission [MOIF-CT-2006-039855]; French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center; National Institutes of Health (NIH), Bethesda, MD; National Science Foundation Ecology of Infectious Disease [EF-0914384]; National Institutes of Health [R01 GM-083224] FX The authors are grateful to Laura C. Harrington and Alongkot Ponlawat for providing mosquito eggs and field temperature data from Thailand. We thank Richard G. Jarman and Alan L. Rothman for providing the DENV isolates, Pam Chin for expert technical support, and Linda M. Styer and Caroline Lego for their help during vector competence assays in the first experiment. Anna-Bella Failloux, Marie Vazeille, Laurence Mousson, Estelle Martin, and Camilo Arias-Goeta provided support during the second experiment. Christopher M. Barker and Romain Gallet helped with fruitful discussions. Two anonymous reviewers provided helpful comments on a previous version of the manuscript. L. L. was supported by Marie Curie Fellowship MOIF-CT-2006-039855 from the European Commission and French Agence Nationale de la Recherche Grant ANR-09-RPDOC-007-01. T.W.S. received support from the Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center, National Institutes of Health (NIH), Bethesda, MD. This study was supported by National Science Foundation Ecology of Infectious Disease Program Grant EF-0914384 and National Institutes of Health Grant R01 GM-083224. NR 42 TC 168 Z9 173 U1 5 U2 88 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 3 PY 2011 VL 108 IS 18 BP 7460 EP 7465 DI 10.1073/pnas.1101377108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 758YF UT WOS:000290203100040 PM 21502510 ER PT J AU Johnson, EA Dao, TL Guignet, MA Geddes, CE Koemeter-Cox, AI Kan, RK AF Johnson, Erik A. Dao, Thuy L. Guignet, Michelle A. Geddes, Claire E. Koemeter-Cox, Andrew I. Kan, Robert K. TI Increased expression of the chemokines CXCL1 and MIP-1 alpha by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; INFLAMMATORY CYTOKINES; INDUCED NEUROPATHOLOGY; ALZHEIMERS-DISEASE; MOUSE ASTROCYTES; SPINAL-CORD; INJURY; PROTEIN; RECRUITMENT; ACTIVATION AB Background: Exposure to the nerve agent soman (GD) causes neuronal cell death and impaired behavioral function dependent on the induction of status epilepticus (SE). Little is known about the maturation of this pathological process, though neuroinflammation and infiltration of neutrophils are prominent features. The purpose of this study is to quantify the regional and temporal progression of early chemotactic signals, describe the cellular expression of these factors and the relationship between expression and neutrophil infiltration in damaged brain using a rat GD seizure model. Methods: Protein levels of 4 chemokines responsible for neutrophil infiltration and activation were quantified up to 72 hours in multiple brain regions (i.e. piriform cortex, hippocampus and thalamus) following SE onset using multiplex bead immunoassays. Chemokines with significantly increased protein levels were localized to resident brain cells (i.e. neurons, astrocytes, microglia and endothelial cells). Lastly, neutrophil infiltration into these brain regions was quantified and correlated to the expression of these chemokines. Results: We observed significant concentration increases for CXCL1 and MIP-1 alpha after seizure onset. CXCL1 expression originated from neurons and endothelial cells while MIP-1 alpha was expressed by neurons and microglia. Lastly, the expression of these chemokines directly preceded and positively correlated with significant neutrophil infiltration in the brain. These data suggest that following GD-induced SE, a strong chemotactic response originating from various brain cells, recruits circulating neutrophils to the injured brain. Conclusions: A strong induction of neutrophil attractant chemokines occurs following GD-induced SE resulting in neutrophil influx into injured brain tissues. This process may play a key role in the progressive secondary brain pathology observed in this model though further study is warranted. C1 [Johnson, Erik A.; Dao, Thuy L.; Guignet, Michelle A.; Geddes, Claire E.; Koemeter-Cox, Andrew I.; Kan, Robert K.] USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Johnson, EA (reprint author), USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. EM erik.a.johnson1@us.army.mil FU U.S. Army Medical Research and Materiel Command; Defense Threat Reduction Agency (DTRA) [110001_04_RC_C, W911NF-07-D-001] FX This work was supported by the U.S. Army Medical Research and Materiel Command and by the Defense Threat Reduction Agency (DTRA) under contract #110001_04_RC_C and W911NF-07-D-001. The authors would like to thank Ms. Jessica Leuschner, Mr. Colin Smith, Mr. Mayank Patel, Ms. Jennifer Peeling, Ms. Marissa Babnew and Ms. Dominique Scutella for their expert technical support. We would also like to thank Dr. Wolfgang Streit, University of Florida Department of Neuroscience, for his assistance in identifying dystrophic microglia. The findings contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the U.S. Army or Department of Defense. NR 56 TC 38 Z9 42 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD MAY 2 PY 2011 VL 8 AR 41 DI 10.1186/1742-2094-8-41 PG 10 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 771ZL UT WOS:000291199100001 PM 21535896 ER PT J AU Bahder, TB AF Bahder, Thomas B. TI Phase estimation with nonunitary interferometers: Information as a metric SO PHYSICAL REVIEW A LA English DT Article ID STANDARD QUANTUM LIMIT; LUMINOUS ETHER; STATES; STATISTICS; PROSPECTS; PHOTONS AB Determining the phase in one arm of a quantum interferometer is discussed taking into account the three nonideal aspects in real experiments: nondeterministic state preparation, nonunitary state evolution due to losses during state propagation, and imperfect state detection. A general expression is written for the probability of a measurement outcome taking into account these three nonideal aspects. As an example of applying the formalism, the classical Fisher information and fidelity (Shannon mutual information between phase and measurements) are computed for few-photon Fock and N00N states input into a lossy Mach-Zehnder interferometer. These three nonideal aspects lead to qualitative differences in phase estimation, such as a decrease in fidelity and Fisher information that depends on the true value of the phase. C1 US Army RDECOM, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Bahder, TB (reprint author), US Army RDECOM, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. NR 59 TC 3 Z9 3 U1 2 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY 2 PY 2011 VL 83 IS 5 AR 053601 DI 10.1103/PhysRevA.83.053601 PG 14 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 757SL UT WOS:000290107900003 ER PT J AU Chen, MM AF Chen, Michael M. TI Analytical Approach to Ballistic Dispersion of Projectile Weapons Based on Variant Launch Velocity SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article AB This study quantifies the contribution of variant projectile velocity at a gun muzzle to its dispersion at an aim point from an analytical approach. The dispersion was formulated on the basis of stochastic physical conditions including potential crosswind effect. As a result, the statistical quantities of projectile impact distribution could be obtained from the stochastic formulation. In addition, this research proposes correction factors that may be needed when comparing dispersion in angular mil at multiple downrange distances. The significance of the correction factors was demonstrated through a few application examples. [DOI: 10.1115/1.4003430] C1 USA, Ballist Struct & Launch Dynam Branch, Weap & Mat Res Directorate, Res Lab,RDRL WML G, Aberdeen Proving Ground, MD 21005 USA. RP Chen, MM (reprint author), USA, Ballist Struct & Launch Dynam Branch, Weap & Mat Res Directorate, Res Lab,RDRL WML G, Aberdeen Proving Ground, MD 21005 USA. EM michael.m.chen@us.army.mil FU Maneuver Ammunition Systems FX This work was supported in part by the U.S. Army Project Manager, Maneuver Ammunition Systems. NR 9 TC 0 Z9 0 U1 2 U2 6 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAY PY 2011 VL 78 IS 3 AR 031015 DI 10.1115/1.4003430 PG 9 WC Mechanics SC Mechanics GA 866LH UT WOS:000298381800015 ER PT J AU Peng, W Zhang, ZY Gogos, G Gazonas, G AF Peng, Wen Zhang, Zhaoyan Gogos, George Gazonas, George TI Fluid Structure Interactions for Blast Wave Mitigation SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article DE fluid-structure interaction; blast wave mitigation; shock wave; resistance ID NUMERICAL-SIMULATION; FREESTANDING PLATES; AIR BLAST AB The dynamic response of a free-standing plate subjected to a blast wave is studied numerically to investigate the effects of fluid-structure interaction (FSI) in blast wave mitigation. Previous work on the FSI between a blast wave and a free-standing plate (Kambouchev, N., , 2006, "Nonlinear Compressibility Effects in Fluid-Structure Interaction and Their Implications on the Air-Blast Loading of Structures," J. Appl. Phys., 100(6), p. 063519) has assumed a constant atmospheric pressure at the back of the plate and neglected the resistance caused by the shock wave formation due to the receding motion of the plate. This paper develops an FSI model that includes the resistance caused by the shock wave formation at the back of the plate. The numerical results show that the resistance to the plate motion is especially pronounced for a light plate, and as a result, the previous work overpredicts the mitigation effects of FSI. Therefore, the effects of the interaction between the plate and the shock wave formation at the back of the plate should be considered in blast wave mitigation. [DOI: 10.1115/1.4002758] C1 [Peng, Wen; Zhang, Zhaoyan; Gogos, George] Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. [Gazonas, George] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Peng, W (reprint author), Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. EM zzhang5@unl.edu OI Gazonas, George/0000-0002-2715-016X FU U.S. Army Research Office [W911NF-04-2-0011] FX Financial support for this study by the U.S. Army Research Office Contract No. W911NF-04-2-0011 is gratefully acknowledged. NR 17 TC 5 Z9 5 U1 0 U2 12 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAY PY 2011 VL 78 IS 3 AR 031016 DI 10.1115/1.4002758 PG 8 WC Mechanics SC Mechanics GA 866LH UT WOS:000298381800016 ER PT J AU Hoffman, RC Mott, AG Ferry, MJ Pritchett, TM Shensky, W Orlicki, JA Martin, GR Dougherty, J Leadore, JL Rawlett, AM Park, DH AF Hoffman, Robert C. Mott, Andrew G. Ferry, Michael J. Pritchett, Timothy M. Shensky, William, III Orlicki, Joshua A. Martin, George R. Dougherty, Joseph Leadore, Julia L. Rawlett, Adam M. Park, Dong Hun TI Poling of visible chromophores in millimeter-thick PMMA host SO OPTICAL MATERIALS EXPRESS LA English DT Article ID POLYMER-FILMS; ORIENTATION; GENERATION AB We report the direct high-voltage poling of the chromophores 4methoxy- 4'-nitrostilbene (MNS) and 2-methyl-4-nitroaniline (MNA) in a 1.2 mm thick polymethylmethacrylate (PMMA) host. The DC fields used to pole the guest-host system varied in strength from 58 to 67 V mu m(-1), and the presence of chromophore orientation in the poled samples was subsequently analyzed via Maker fringe analysis. We observed values of the SHG coefficient d(33) of 0.7 to 1.75pm/V at 532nm. (C) 2011 Optical Society of America C1 [Hoffman, Robert C.; Mott, Andrew G.; Ferry, Michael J.; Pritchett, Timothy M.; Shensky, William, III] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Orlicki, Joshua A.; Martin, George R.; Dougherty, Joseph; Leadore, Julia L.; Rawlett, Adam M.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. [Park, Dong Hun] Lab Phys Sci, College Pk, MD 20740 USA. RP Hoffman, RC (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.c.hoffman@us.army.mil RI Shensky, William/J-7012-2014 NR 16 TC 2 Z9 2 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD MAY 1 PY 2011 VL 1 IS 1 BP 67 EP 77 PG 11 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 875PZ UT WOS:000299046500009 ER PT J AU Metcalfe, GD Readinger, ED Enck, R Shen, HG Wraback, M Woodward, NT Poplawsky, J Dierolf, V AF Metcalfe, Grace D. Readinger, Eric D. Enck, Ryan Shen, Hongen Wraback, Michael Woodward, Nathaniel T. Poplawsky, Jon Dierolf, Volkmar TI Near-infrared photoluminescence properties of neodymium in in situ doped AlN grown using plasma-assisted molecular beam epitaxy SO OPTICAL MATERIALS EXPRESS LA English DT Article ID THIN-FILMS; SEMICONDUCTORS; SPECTROSCOPY; LUMINESCENCE; TEMPERATURE; EMISSION; ERBIUM; GAN AB We present luminescence spectroscopy measurements of in situ Nd doped AlN grown by plasma-assisted molecular beam epitaxy. A Nd concentration as high as 0.08 at. % is incorporated into the host material. The Nd incorporation efficiency within the AlN matrix is found to be highly sensitive to the Al flux but independent of the substrate temperature (between 800 degrees C to 950 degrees C). Photoluminescence, photoluminescence excitation, and combined excitation-emission spectroscopy (CEES) spectra are used to identify the Stark sublevels of the following manifolds: (4)I(9/2), (4)I(11/2), (4)I(13/2), (4)F(3/2), (4)F(5/2), (2)H(9/2), (4)F(7/2), (4)S(3/2), (4)G(5/2), and (4)G(7/2). A main Nd incorporation site and two minority sites are identified using CEES measurements. (C) 2011 Optical Society of America C1 [Metcalfe, Grace D.; Readinger, Eric D.; Enck, Ryan; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. [Woodward, Nathaniel T.; Poplawsky, Jon; Dierolf, Volkmar] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil RI Poplawsky, Jonathan/Q-2456-2015 OI Poplawsky, Jonathan/0000-0002-4272-7043 NR 13 TC 6 Z9 6 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD MAY 1 PY 2011 VL 1 IS 1 BP 78 EP 84 PG 7 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 875PZ UT WOS:000299046500010 ER PT J AU LaRussa, PS Edwards, KM Dekker, CL Klein, NP Halsey, NA Marchant, C Baxter, R Engler, RJM Kissner, J Slade, BA AF LaRussa, Philip S. Edwards, Kathryn M. Dekker, Cornelia L. Klein, Nicola P. Halsey, Neal A. Marchant, Colin Baxter, Roger Engler, Renata J. M. Kissner, Jennifer Slade, Barbara A. TI Understanding the Role of Human Variation in Vaccine Adverse Events: The Clinical Immunization Safety Assessment Network SO PEDIATRICS LA English DT Article DE CISA Network; vaccine safety; adverse events following immunization ID DATA-COLLECTION; CASE-DEFINITION; GUIDELINES; EXPOSURE; VIRUS; RISK; TIV AB The Clinical Immunization Safety Assessment (CISA) Network is a collaboration between the Centers for Disease Control and Prevention (CDC) and 6 academic medical centers to provide support for immunization safety assessment and research. The CISA Network was established by the CDC in 2001 with 4 primary goals: (1) develop research protocols for clinical evaluation, diagnosis, and management of adverse events following immunization (AEFI); (2) improve the understanding of AEFI at the individual level, including determining possible genetic and other risk factors for predisposed people and subpopulations at high risk; (3) develop evidence-based algorithms for vaccination of people at risk of serious AEFI; and (4) serve as subject-matter experts for clinical vaccine-safety inquiries. CISA Network investigators bring in-depth clinical, pathophysiologic, and epidemiologic expertise to assessing causal relationships between vaccines and adverse events and to understanding the pathogenesis of AEFI. CISA Network researchers conduct expert reviews of clinically significant adverse events and determine the validity of the recorded diagnoses on the basis of clinical and laboratory criteria. They also conduct special studies to investigate the possible pathogenesis of adverse events, assess relationships between vaccines and adverse events, and maintain a centralized repository for clinical specimens. The CISA Network provides specific clinical guidance to both health care providers who administer vaccines and those who evaluate and treat patients with possible AEFI. The CISA Network plays an important role in providing critical immunization-safety data and expertise to inform vaccine policy-makers. The CISA Network serves as a unique resource for vaccine-safety monitoring efforts conducted at the CDC. Pediatrics 2011;127:S65-S73 C1 [LaRussa, Philip S.] Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA. [Edwards, Kathryn M.; Kissner, Jennifer] Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Res Program, Nashville, TN USA. [Dekker, Cornelia L.] Stanford Univ, Dept Pediat, Sch Med, Div Pediat Infect Dis, Stanford, CA 94305 USA. [Klein, Nicola P.; Baxter, Roger] Kaiser Permanente, Vaccine Study Ctr, Oakland, CA USA. [Halsey, Neal A.] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD USA. [Halsey, Neal A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Marchant, Colin] Boston Med Ctr, Dept Pediat, Boston, MA USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Natl Branch, Washington, DC 20307 USA. [Slade, Barbara A.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP LaRussa, PS (reprint author), Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA. EM plarussa@columbia.edu FU National Institutes of Health (NIH); CDC [200-2002-00732]; Sanofi Pasteur; Novartis; Wyeth; CSL; GlaxoSmithKline; Merck Co; Wyeth (Pfizer); MedImmune; Johns Hopkins University; Berna; Intercel; Wyeth (Pfizer Inc); Pfizer; Protein Sciences; Merck FX Dr LaRussa receives contract funding from the National Institutes of Health (NIH) and the CDC and currently serves on a Novartis data safety monitoring board; Dr Edwards receives contract funding from the NIH and the CDC, has received contract support within the past 3 years from Sanofi Pasteur, Novartis, Wyeth, and CSL for the conduct of clinical vaccine studies, and has served as a consultant to Nexbio and PATH; Dr Dekker receives contract funding from the NIH and the CDC; Dr Klein receives contract funding from the CDC and research support from GlaxoSmithKline, Merck & Co, Sanofi Pasteur, Wyeth (Pfizer), Novartis and MedImmune; Dr Halsey receives contract funding from the CDC and is compensated for serving on safety monitoring committees for studies of vaccines for Merck and Novartis, has received an honorarium for training and support for travel from Sanofi-MSD, a company in France, has research grants through Johns Hopkins University for studies of unrelated vaccines in Guatemala from Berna and Intercel, and has received support for a study of a Merck HPV vaccine in Peru but receives no support for the effort in Peru; Dr Marchant receives contract funding from the CDC and has performed clinical research for GlaxoSmithKline, Sanofi Pasteur, Merck, Wyeth (Pfizer Inc), MedImmune, and Novartis, has served as a consultant to GlaxoSmithKline, Sanofi Pasteur, MedImmune, and Novartis, and has given lectures sponsored by GlaxoSmithKline and Sanofi Pasteur; Dr Baxter receives contract funding from the CDC and research grants from Sanofi Pasteur, MedImmune, Novartis, GlaxoSmithKline, Pfizer, Protein Sciences, and Merck. Drs Engler, Kissner, and Slade have indicated they have no financial relationships relevant to this article to disclose.; This work was supported by CDC contract 200-2002-00732. NR 31 TC 17 Z9 17 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2011 VL 127 SU 1 BP S65 EP S73 DI 10.1542/peds.2010-1722J PG 9 WC Pediatrics SC Pediatrics GA 846QK UT WOS:000296918100010 PM 21502239 ER PT J AU Salmon, DA Akhtar, A Mergler, MJ Vannice, KS Izurieta, H Ball, R Lee, GM Vellozzi, C Garman, P Cunningham, F Gellin, B Koh, H Lurie, N AF Salmon, Daniel A. Akhtar, Aysha Mergler, Michelle J. Vannice, Kirsten S. Izurieta, Hector Ball, Robert Lee, Grace M. Vellozzi, Claudia Garman, Patrick Cunningham, Francesca Gellin, Bruce Koh, Howard Lurie, Nicole CA H1N1 Working Grp Fed Immunization TI Immunization-Safety Monitoring Systems for the 2009 H1N1 Monovalent Influenza Vaccination Program SO PEDIATRICS LA English DT Article DE vaccine safety; H1N1 influenza ID DEFENSE MEDICAL SURVEILLANCE; EVENT REPORTING SYSTEM; VACCINES; DISEASE; COMPLICATIONS; EXPERIENCE AB The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20% of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/press-releases/2009-releases/survey-40-adults-absolutely-certain-h1n1vaccine.html and www.med.umich.edu/mott/npch/reports/h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines. Pediatrics 2011;127:S78-S86 C1 [Salmon, Daniel A.] US Dept HHS, Natl Vaccine Program Off, Off Publ Hlth & Sci, Off Secretary, Washington, DC 20201 USA. [Izurieta, Hector] US FDA, Analyt Epidemiol Branch, Div Epidemiol, Rockville, MD 20857 USA. [Akhtar, Aysha; Ball, Robert] US FDA, Off Biostat & Epidemiol, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA. [Lee, Grace M.] Harvard Univ, Sch Med, Dept Populat Med, Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Lee, Grace M.] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Lee, Grace M.] Dept Lab Med, Boston, MA USA. [Vellozzi, Claudia] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA USA. [Garman, Patrick] USA, Mil Vaccine Agcy, Falls Church, VA USA. [Cunningham, Francesca] Pharm Benefits Management Serv, Natl Ctr Patient Safety, Dept Vet Affairs, Washington, DC USA. RP Salmon, DA (reprint author), US Dept HHS, Natl Vaccine Program Off, Off Publ Hlth & Sci, Off Secretary, 200 Independence Ave,SW Room 715H, Washington, DC 20201 USA. EM daniel.salmon@hhs.gov OI Krause, Philip/0000-0002-1045-7536; Hughes, Michelle/0000-0002-4436-2236 NR 27 TC 29 Z9 30 U1 0 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2011 VL 127 SU 1 BP S78 EP S86 DI 10.1542/peds.2010-1722L PG 9 WC Pediatrics SC Pediatrics GA 846QK UT WOS:000296918100012 PM 21502251 ER PT J AU Colacicco-Mayhugh, MG Grieco, JP Putnam, JL Burkett, DA Coleman, RE AF Colacicco-Mayhugh, Michelle G. Grieco, John P. Putnam, John L. Burkett, Douglas A. Coleman, Russell E. TI Impact of Phlebotomine Sand Flies on United States Military Operations at Tallil Air Base, Iraq: 5. Impact of Weather on Sand Fly Activity SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE sand fly; Phlebotomus; climate; light trap; Iraq ID ZOONOTIC CUTANEOUS LEISHMANIASIS; PSYCHODIDAE; DIPTERA; SANDFLIES; PAPATASI; VECTOR; AREA; MOONLIGHT AB In this study, we examined the effect of weather and moon illumination on sand fly activity, as measured by light trap collections made between 2 May 2003 and 25 October 2004 at Tallil Air Base, Iraq. Wind speed, temperature, dew point, percentage of sky cover, and moon illumination were entered into principal components analysis. The resulting principal components were entered into stepwise regression to develop a model of the impact of the weather on sand fly collections. Wind speed, percentage of sky cover, and moon illumination each had a strong inverse relationship with the number of sand flies collected, whereas temperature displayed a direct relationship to sand fly collections. Our data indicate that sand fly light trap catches at Tallil Air Base are highest on warm, clear nights with low wind speed and minimal illumination from the moon. C1 [Colacicco-Mayhugh, Michelle G.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Grieco, John P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Putnam, John L.] USAF Acad, Ft Collins, CO 80840 USA. [Burkett, Douglas A.] Armed Forces Pest Management Board, Silver Spring, MD 20910 USA. [Coleman, Russell E.] United States Army, Theater Army Med Lab 520, Tallil Air Base, Iran. RP Coleman, RE (reprint author), USA Med Mat Dev Act, 1430 Vet Dr, Ft Detrick, MD 21702 USA. EM Russell.coleman@us.army.mil NR 30 TC 8 Z9 8 U1 1 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2011 VL 48 IS 3 BP 538 EP 545 DI 10.1603/ME10128 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 810JY UT WOS:000294122800009 PM 21661314 ER PT J AU Turell, M Dave, K Mayda, M Parker, Z Coleman, R Dave, S Strickman, D AF Turell, M. Dave, K. Mayda, M. Parker, Z. Coleman, R. Dave, S. Strickman, D. TI Wicking Assay for the Rapid Detection of Rift Valley Fever Viral Antigens in Mosquitoes (Diptera: Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE arbovirus; rapid detection; dipstick; surveillance ID CULEX-PIPIENS; VECTOR COMPETENCE; VIRUS; EGYPT AB Rift Valley fever virus (RVFV) causes outbreaks of severe disease in domestic ungulates as well as humans in Africa. There is a logical concern that RVFV could be introduced into the Americas and cause significant health and economic damage based on the precedent of the introduction and spread of West Nile virus (WNV). Unfortunately, there are currently no licensed diagnostic assays available for RVFV in the Americas. In this work, we report on the ability of a novel dipstick assay, VectorTest RVFV antigen assay, modeled on the VecTest assay for WNV, to detect a RVFV-infected female within a pool of mosquitoes. The dipsticks provided results in <20 min, were easy to use, and did not require a laboratory with containment facilities. Although readily able to detect a mosquito with a disseminated RVFV infection, it only occasionally detected RVFV in a mosquito with a nondisseminated infection, and therefore may fail to detect some pools that actually contain one or more positive mosquitoes. The RVFV dipstick assay was highly specific and did not react with samples to which had been added yellow fever, West Nile, Venezuelan equine encephalitis, sandfly fever Naples, sandfly fever Sicilian, or sandfly fever Toscana viruses. The RVFV assay can provide a rapid, safe, easy-to-use assay to alert public health personnel to the presence of RVFV in mosquitoes. Results from this assay will allow a rapid threat assessment and the focusing of vector control measures in high-risk areas. C1 [Turell, M.] USA, Med Res Inst Infect Dis, Dept Vector Assessment, Div Virol, Ft Detrick, MD 21702 USA. [Dave, K.; Dave, S.] VecTOR Test Syst, Thousand Oaks, CA 91320 USA. [Mayda, M.; Parker, Z.; Coleman, R.; Strickman, D.] Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. RP Turell, M (reprint author), USA, Med Res Inst Infect Dis, Dept Vector Assessment, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amedd.army.mil FU DoD [W81XWH-04-C-0045] FX We thank J. Naslund, Swedish Defense Research Agency (Department of Chemical, Biological, Radiological, and Nuclear Defense and Security, Umea, Sweden), for providing the RVFV cDNA; D. Dohm, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), for his assistance in testing the mosquitoes; J. Williams, USAMRIID, for caring for the hamsters; D. Nash and T. Hanson, USAMRIID, for rearing the mosquitoes; S. Norris, USAMRIID, for statistical analysis; and K. Kenyon, USAMRIID, for her editorial suggestions. This work was supported in part by DoD SBIR Contract W81XWH-04-C-0045 to VecTOR Test Systems. NR 19 TC 5 Z9 5 U1 0 U2 6 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2011 VL 48 IS 3 BP 628 EP 633 DI 10.1603/ME10219 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 810JY UT WOS:000294122800019 PM 21661324 ER PT J AU Bahn, RS Burch, HB Cooper, DS Garber, JR Greenlee, C Klein, I Laurberg, P McDougall, IR Montori, VM Rivkees, SA Ross, DS Sosa, JA Stan, MN AF Bahn, Rebecca S. Burch, Henry B. Cooper, David S. Garber, Jeffrey R. Greenlee, Carol Klein, Irwin Laurberg, Peter McDougall, I. Ross Montori, Victor M. Rivkees, Scott A. Ross, Douglas S. Sosa, Julie Ann Stan, Marius N. TI HYPERTHYROIDISM AND OTHER CAUSES OF THYROTOXICOSIS: MANAGEMENT GUIDELINES OF THE AMERICAN THYROID ASSOCIATION AND AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS SO ENDOCRINE PRACTICE LA English DT Article ID ENDOGENOUS SUBCLINICAL HYPERTHYROIDISM; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY; AMIODARONE-INDUCED THYROTOXICOSIS; PERCUTANEOUS ETHANOL INJECTION; HUMAN CHORIONIC-GONADOTROPIN; DRUG-INDUCED AGRANULOCYTOSIS; RADIOACTIVE IODINE THERAPY; MULTINODULAR TOXIC GOITER; QUALITY-OF-LIFE; PARATHYROID-HORMONE ASSAY AB Objective: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition. Methods: The development of these guidelines was commissioned by the American Thyroid Association in association with the American Association of Clinical Endocrinologists. The American Thyroid Association and American Association of Clinical Endocrinologists assembled a task force of expert clinicians who authored this report. The task force examined relevant literature using a systematic PubMed search supplemented with additional published materials. An evidence-based medicine approach that incorporated the knowledge and experience of the panel was used to develop the text and a series of specific recommendations. The strength of the recommendations and the quality of evidence supporting each was rated according to the approach recommended by the Grading of Recommendations, Assessment, Development, and Evaluation Group. Results: Clinical topics addressed include the initial evaluation and management of thyrotoxicosis; management of Graves' hyperthyroidism using radioactive iodine, antithyroid drugs, or surgery; management of toxic multinodular goiter or toxic adenoma using radioactive iodine or surgery; Graves' disease in children, adolescents, or pregnant patients; subclinical hyperthyroidism; hyperthyroidism in patients with Graves' ophthalmopathy; and management of other miscellaneous causes of thyrotoxicosis. Conclusions: One hundred evidence-based recommendations were developed to aid in the care of patients with thyrotoxicosis and to share what the task force believes is current, rational, and optimal medical practice. C1 [Bahn, Rebecca S.; Montori, Victor M.; Stan, Marius N.] Mayo Clin, Div Metab Endocrinol & Nutr, Rochester, MN 55905 USA. [Burch, Henry B.] Walter Reed Army Med Ctr, Div Endocrinol & Metab, Washington, DC 20307 USA. [Cooper, David S.] Johns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD USA. [Garber, Jeffrey R.] Harvard Vanguard Med Associates, Div Endocrine, Boston, MA USA. [Greenlee, Carol] Western Slope Endocrinol, Grand Junction, CO USA. [Klein, Irwin] N Shore Univ Hosp, Thyroid Unit, Manhasset, NY USA. [Laurberg, Peter] Aarhus Univ Hosp, Dept Endocrinol, Aalborg, Denmark. [McDougall, I. Ross] Stanford Univ, Sch Med, Dept Radiol, Div Nucl Med, Stanford, CA 94305 USA. [McDougall, I. Ross] Stanford Univ, Sch Med, Div Endocrinol, Dept Med, Stanford, CA 94305 USA. [Rivkees, Scott A.] Yale Pediat Thyroid Ctr, Dept Pediat, New Haven, CT USA. [Ross, Douglas S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Sosa, Julie Ann] Yale Univ, Sch Med, Div Endocrine Surg, New Haven, CT USA. [Sosa, Julie Ann] Yale Univ, Sch Med, Div Surg Oncol, New Haven, CT USA. RP Bahn, RS (reprint author), Mayo Clin, Div Metab Endocrinol & Nutr, 200 1st St SW, Rochester, MN 55905 USA. EM bahn.rcbecca@mayo.edu FU Genzyme FX Disclosure Information for 2 years before May 2010 and the known future as of May 2010. D.R. is a consultant for Abbott Laboratories and has received research grant support from Genzyme. For all other authors, no competing financial interests exist. NR 360 TC 183 Z9 193 U1 2 U2 15 PU AMER ASSOC CLINICAL ENDOCRINOLOGISTS PI JACKSONVILLE PA 245 RIVERSIDE AVENUE, STE 200, JACKSONVILLE, FL 32202 USA SN 1530-891X EI 1934-2403 J9 ENDOCR PRACT JI Endocr. Pract. PD MAY-JUN PY 2011 VL 17 IS 3 BP 456 EP 520 PG 65 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 793EK UT WOS:000292803000017 PM 21700562 ER PT J AU Perkins, MW Pierre, Z Rezk, P Song, J Oguntayo, S Sciuto, AM Doctor, BP Nambiar, MP AF Perkins, Michael W. Pierre, Zdenka Rezk, Peter Song, Jian Oguntayo, Samuel Sciuto, Alfred M. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Acute Changes in Pulmonary Function Following Microinstillation Inhalation Exposure to Soman in Nonatropenized Guinea Pigs SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE barometric plethysmography; inhalation exposure; nerve agents; pulmonary function; respiratory toxicology ID NERVE AGENT-VX; INDUCED RESPIRATORY DEPRESSION; NONNEURONAL CHOLINERGIC SYSTEM; TISSUE CHOLINESTERASE; SPECIES VARIATION; BLOOD-BRAIN; ATROPINE; INJURY; RATS; SARIN AB Barometric whole-body plethysmography (WBP) was used to examine pulmonary functions at 4 and 24 hours postexposure to soman (GD) in guinea pigs without therapeutics to improve survival. Endotracheal aerosolization by microinstillation was used to administer GD (280, 561, and 841 mg/m(3)) or saline to anesthetized guinea pigs. Significant increases in respiratory frequency (RF), tidal volume (TV), and minute volume (MV) were observed with 841 mg/m(3) GD at 4 hours and that were reduced at 24 hours postexposure. A dose-dependent increase in peak inspiration flow and peak expiration flow was present at 4-hour post-GD exposure that was reduced at 24 hours. Time of inspiration and expiration were decreased in all doses of GD exposure at 4 and 24 hours, with significant inhibition at 841 mg/m(3). End-expiratory pause (EEP) increased at 280 and 561 mg/m(3), but decreased in animals exposed 841 mg/m(3) at 24 hours postexposure. Pseudo-lung resistance (Penh) and pause followed similar patterns and increased at 4 hours, but decreased at 24 hours postexposure to 841 mg/m(3) of GD compared to control. These studies indicate GD exposure induces dose-dependent changes in pulmonary function that are significant at 841 mg/m(3) at 4 hours and remains 24 hours postexposure. Furthermore, at 4 hours, GD induces bronchoconstriction possibly due to copious airway secretion and ongoing lung injury in addition to cholinergic effects, while at 24 hours GD induces bronchodilation a possible consequence of initial compensatory mechanisms. C1 [Song, Jian; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Perkins, Michael W.; Pierre, Zdenka; Rezk, Peter; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD USA. EM madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency [3.F0006_08_WR_C] FX The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: Defense Threat Reduction Agency, proposal # 3.F0006_08_WR_C. NR 48 TC 5 Z9 6 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAY PY 2011 VL 30 IS 3 BP 348 EP 357 DI 10.1177/1091581810397960 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 795OB UT WOS:000292982400008 PM 21527644 ER PT J AU Mal, S Nori, S Narayan, J Prater, JT AF Mal, Siddhartha Nori, Sudhakar Narayan, Jagdish Prater, John T. TI Defect-mediated ferromagnetism and controlled switching characteristics in ZnO SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID ELECTRON-PARAMAGNETIC RESONANCE; DOPED ZNO; IRRADIATED ZNO; OXIDE FILMS; ZINC-OXIDE; THIN-FILMS; SEMICONDUCTORS; VACANCIES AB We report a detailed study of the structural, chemical, electrical, and magnetic properties of undoped ZnO thin films grown under different conditions and the films that were annealed in various environments and irradiated with an ultraviolet laser. Samples prepared in low oxygen pressure or subsequently annealed in vacuum have always been strongly magnetic. Oxygen-annealed films displayed a sequential transition from the ferromagnetic to the diamagnetic state as a function of the annealing temperature. Reversible switching of room temperature ferromagnetism and n-type conductivity have been demonstrated either by annealing in different environments or by a novel laser irradiation treatment. Enhancements in both the electrical conductivity and magnetic moment have been controlled precisely with laser pulses, without altering the crystal structure. Electron paramagnetic resonance data were found to be in good agreement with the magnetization and conductivity measurements. Our secondary ion mass spectrometer and electron energy loss spectrometer studies conclusively rule out the presence of any external ferromagnetic impurities. C1 [Mal, Siddhartha; Nori, Sudhakar; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, John T.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu RI Nori, Sudhakar/E-8111-2010 FU Army Research Office [W911NF-04-D-0003] FX The authors thank Prof. A.I. Smirnov and Dr. S. Nellutla for the EPR measurements. The authors are pleased to acknowledge the support of the Army Research Office under Grant No. W911NF-04-D-0003. NR 43 TC 13 Z9 13 U1 0 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD MAY PY 2011 VL 26 IS 10 BP 1298 EP 1308 DI 10.1557/jmr.2011.74 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 793NV UT WOS:000292831300015 ER PT J AU Stinner, DJ Hsu, JR AF Stinner, Daniel J. Hsu, Joseph R. TI Untitled response SO MILITARY MEDICINE LA English DT Letter C1 [Stinner, Daniel J.; Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Stinner, DJ (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP II EP III PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700002 ER PT J AU Bedno, SA Gardiner, B Li, YZ Wiesen, AR Firestone, JA Niebuhr, DW AF Bedno, Sheryl A. Gardiner, Bradley Li, Yuanzhang Wiesen, Andrew R. Firestone, Jordan A. Niebuhr, David W. TI US Military Recruits Waived for Pathological Curvature of the Spine: Increased Risk of Discharge From Service SO MILITARY MEDICINE LA English DT Article ID UNTREATED IDIOPATHIC SCOLIOSIS; NATURAL-HISTORY; DEFORMITY AB Selective accession waivers for medically disqualifying conditions like spinal curvature are one way the military meets its manpower needs. We evaluated retention patterns during the first 2 years of service of a cohort of military recruits with waivers for pathological curvature of the spine (spinal curvature). Recruits waived for spinal curvature (n = 417), who accessed from 1998 to 2005 were identified and matched with 3 qualified recruits. Kaplan-Meier survival analysis and Cox proportional hazards model were used to compare survival patterns and adjusted attrition hazard estimates. Waived recruits experienced significantly increased risk of "all cause" discharge (relative risk = 1.3; 95% confidence interval: 1.1, 1.5) and "existing prior to service" discharge (relative risk = 2.4; confidence interval: 1.6, 3.5). Despite the increased risk of discharge, current waiver criteria allowed a majority with spinal curvature to complete at least 2 years of service. Policy makers must consider risks and benefits before modifying the current accession standard for spinal curvature. C1 [Bedno, Sheryl A.; Li, Yuanzhang; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD 20910 USA. [Bedno, Sheryl A.] Uniformed Serv Univ Hlth Sci, Occupat & Environm Med Residency Program, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gardiner, Bradley; Wiesen, Andrew R.] Madigan Army Med Ctr, ATTN MCHJ PV, Tacoma, WA 98431 USA. [Firestone, Jordan A.] Univ Washington, Dept Environm & Occupat Hlth Sci, Sch Publ Hlth, Seattle, WA 98195 USA. RP Bedno, SA (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. OI Li, Yuanzhang/0000-0001-8872-4430 FU Defense Health Program [847714] FX This study was funded by the Defense Health Program (no. 847714). NR 17 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 519 EP 523 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700012 PM 21634296 ER PT J AU Lande, RG AF Lande, R. Gregory TI Felo De Se: Soldier Suicides in America's Civil War SO MILITARY MEDICINE LA English DT Article AB Objective: This article examined the factors associated with suicide during America's Civil War and the years immediately following the cessation of armed conflict. Methods: Contemporary newspaper reports, complemented by book and journal articles, provide an understanding of the incidence and motivations of suicide. Results: The rate of suicide in the general population dramatically increased in the years following the war's end. During the Civil War, suicides occurred nearly every month, reliably peaking in the spring of each year. Depression and alcohol abuse were major factors associated with military suicides. Conclusion: Emotional disorders and alcohol misuse, when combined with the hardships of war, contributed to a steady rate of suicides during the Civil War. C1 Walter Reed Army Med Ctr, Psychiat Continu Serv, Washington, DC 20307 USA. RP Lande, RG (reprint author), Walter Reed Army Med Ctr, Psychiat Continu Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 25 TC 5 Z9 5 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 531 EP 536 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700014 PM 21634298 ER PT J AU Freeman, RJ Li, YZ Niebuhr, DW AF Freeman, Randall J. Li, Yuanzhang Niebuhr, David W. TI Descriptive Epidemiology and Natural History of Idiopathic Venous Thromboembolism in US Active Duty Enlisted Personnel, 1998-2007 SO MILITARY MEDICINE LA English DT Article ID ACUTE PULMONARY-EMBOLISM; DEEP-VEIN THROMBOSIS; DIAGNOSIS; COMMUNITY AB The estimated incidence of idiopathic venous thromboembolism (IVTE) cases in the United States ranges from 24,000 to 282,000/year. This analysis explores the incidence and prevalence of IVTE in the military and if cases experience increased attrition. The Defense Medical Surveillance System was searched for incident IVTE cases from 1998 through 2007. Enlisted cases were each matched to 3 controls. Kaplan-Meier survival analysis and Cox proportional hazard modeling were performed. We matched 463 cases to 1,389 controls. Outpatient IVTE rates have increased markedly from 1998 through 2007. Cases of all-cause attrition risk (0.56 [95% CI = 0.44, 0.72]) and rates were significantly less than controls (p < 0.0001), and cases of medical attrition risk (1.64 [95% CI = 1.13, 2.37]) and rates were significantly higher (p < 0.01). Increasing rates with lower attrition suggests increasing case prevalence. Health care providers must maintain a high index of suspicion for venous thromboembolism to minimize adverse sequelae affecting health, unit readiness, and medical costs. C1 [Freeman, Randall J.; Li, Yuanzhang; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD 20910 USA. [Freeman, Randall J.] Uniformed Serv Univ Hlth Sci, Occupat & Environm Med Residency Program, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Freeman, RJ (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. OI Li, Yuanzhang/0000-0001-8872-4430 FU AMSARA; National Capital Consortium at the Walter Reed Army Institute of Research; Defense Health Program [847714] FX The authors are grateful to Jean L Otto, MPH, DrPH, Armed Forces Health Surveillance Center, Silver Spring, MD: and Janice K Gary, WRAIR Accession Medical Standards Analysis & Research Activity (AMSARA), for their administrative support. This work was supported by the AMSARA and by the National Capital Consortium Preventive Medicine Residency program at the Walter Reed Army Institute of Research. This study was funded by the Defense Health Program (No. 847714). NR 22 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 537 EP 543 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700015 PM 21634299 ER PT J AU Buckley, M Edwards, H Buckenmaier, CC Plunkett, AR AF Buckley, Michael Edwards, Hisani Buckenmaier, Chester C., III Plunkett, Anthony R. TI Continuous Thoracic Paravertebral Nerve Block in a Working Anesthesia Resident-When Opioids are not an Option SO MILITARY MEDICINE LA English DT Article ID MULTIPLE FRACTURED RIBS; PAIN MANAGEMENT; ANALGESIA; BUPIVACAINE; INFUSION; SURGERY; QUALITY; CANCER; LIFE AB Multiple unilateral rib fractures can cause significant pain and morbidity. Continuous nerve block catheters are often maintained while inpatient, and patients are discharged with oral analgesics. However, in many institutions, this dynamic is changing and patients are being managed effectively with outpatient catheters. A 45-year-old male was presented with fractured right ribs 6 through 9. The patient was an anesthesiology resident and was unable to perform his clinical duties. Single paravertebral nerve blocks were performed at right thoracic levels 6-9. At the T7 level, an indwelling catheter was placed. On post-injury day 18, he was able to discontinue the catheter and there were no associated complications. We report a unique case of a patient with multiple rib fractures who was not able to be exposed to potential side effects of opioids. The use of a continuous thoracic paravertebral nerve in an outpatient setting allowed a faster return to function with no adverse events. C1 [Buckley, Michael; Edwards, Hisani; Buckenmaier, Chester C., III; Plunkett, Anthony R.] Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. RP Buckley, M (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA. NR 26 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 578 EP 580 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700021 PM 21634305 ER PT J AU Chavez, TT Fraser, SL Kassop, D Bowden, LP Skidmore, PJ AF Chavez, Temujin T. Fraser, Susan L. Kassop, David Bowden, Lynden P., III Skidmore, Peter J. TI Disseminated Nocardia cyriacigeorgica Presenting as Right Lung Abscess and Skin Nodule SO MILITARY MEDICINE LA English DT Article ID IDENTIFICATION; PATHOGEN; FEATURES; HOST AB Nocardia species are ubiquitous in the environment and can be found worldwide. Direct inhalation remains the most commonly attributed route of infection with Nocardia asteroides complex, causing 50% of invasive infections. Improved molecular methods have identified a significant proportion of N. asteroides complex isolates to be Nocardia cyriacigeorgica. We report a case of a 58-year-old male working as a contractor in Bagram Air Force Base, Afghanistan, with disseminated N. cyriacigeorgica involving the lung, brain, and dermis. Diagnosis was facilitated by early identification of branched, filamentous bacteria using Fite and gram staining along secA DNA sequencing of clinical isolates. Our patient is the first confirmed case of N. cyriacigeorgica infection in Afghanistan. C1 [Chavez, Temujin T.] Natl Naval Med Ctr, Dept Med, Div Infect Dis, Bethesda, MD 20889 USA. [Fraser, Susan L.; Kassop, David] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Bowden, Lynden P., III] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Skidmore, Peter J.] Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA 30905 USA. RP Chavez, TT (reprint author), Natl Naval Med Ctr, Dept Med, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 20 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 586 EP 588 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700024 PM 21634308 ER PT J AU Cigrang, JA Rauch, SAM Avila, LL Bryan, CJ Goodie, JL Hryshko-Mullen, A Peterson, AL AF Cigrang, Jeffrey A. Rauch, Sheila A. M. Avila, Laura L. Bryan, Craig J. Goodie, Jeffrey L. Hryshko-Mullen, Ann Peterson, Alan L. CA STRONG STAR Consortium TI Treatment of Active-Duty Military With PTSD in Primary Care: Early Findings SO PSYCHOLOGICAL SERVICES LA English DT Article DE primary care; PTSD; treatment; military; veterans ID POSTTRAUMATIC-STRESS-DISORDER; COGNITIVE-PROCESSING THERAPY; RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH PROBLEMS; BEHAVIORAL THERAPY; PROLONGED EXPOSURE; SUICIDE IDEATION; ASSAULT VICTIMS; STEPPED CARE; IRAQ WAR AB The study presents early findings from an ongoing pilot study of a cognitive-behavioral treatment for assisting active-duty military members with deployment-related posttraumatic stress disorder (PTSD) designed for use by psychologists working in an integrated primary care clinic. Treatment protocol is based primarily on Prolonged Exposure but also includes elements of Cognitive Processing Therapy that were adapted for use in primary care. Individuals were recruited from the population of patients consulted to the psychologist by primary care providers during routine clinical care. The 15 participants include active-duty or activated reserve Operation Iraqi Freedom and Operation Enduring Freedom veterans seeking help for deployment-related PTSD symptoms, with a PTSD Checklist-Military Version score 32, and interest in treatment for PTSD in primary care. Baseline and 1-month posttreatment follow-up evaluations were conducted by an independent evaluator. Five participants (33%) dropped out of the intervention after one or two appointments. Using the last observation carried forward for intent-to-treat analyses, the results showed that PTSD severity, depression, and global mental health functioning all significantly improved with the intervention. Fifty percent of treatment completers no longer met criteria for PTSD. C1 [Cigrang, Jeffrey A.; Hryshko-Mullen, Ann] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Rauch, Sheila A. M.] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA. [Rauch, Sheila A. M.] VA Ann Arbor Healthcare Syst, West Haven, CT USA. [Avila, Laura L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Bryan, Craig J.; Peterson, Alan L.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Goodie, Jeffrey L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cigrang, JA (reprint author), Minot AFB, Med Grp 5, Minot, ND 58704 USA. EM jeffrey.cigrang@minot.af.mil RI Rauch, Sheila/K-4450-2015; OI Rauch, Sheila/0000-0001-9686-4011; Bryan, Craig/0000-0002-9714-0733 NR 43 TC 27 Z9 27 U1 2 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2011 VL 8 IS 2 BP 104 EP 113 DI 10.1037/a0022740 PG 10 WC Psychology, Clinical SC Psychology GA 789QJ UT WOS:000292530100005 ER PT J AU Zollinger, WD Poolman, JT Maiden, MCJ AF Zollinger, Wendell D. Poolman, Jan T. Maiden, Martin C. J. TI Meningococcal serogroup B vaccines: will they live up to expectations? SO EXPERT REVIEW OF VACCINES LA English DT Editorial Material DE antigenic variation; factor H-binding protein; fHbp; MenB; OMV; outer membrane vesicle; PorA; Porin A ID MEMBRANE VESICLE VACCINE; NEISSERIA-MENINGITIDIS; BACTERICIDAL ACTIVITY; CONTROLLED-TRIAL; IMMUNOGENICITY; PROTEIN; ANTIBODIES; COMPONENTS; ANTIGENS; STRAINS C1 [Poolman, Jan T.] GlaxoSmithKline Biol, B-1330 Rixensart, Belgium. [Zollinger, Wendell D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Maiden, Martin C. J.] Univ Oxford, Dept Zool, Oxford OX1 3PS, England. RP Poolman, JT (reprint author), GlaxoSmithKline Biol, Rue Inst 89, B-1330 Rixensart, Belgium. EM jan.poolman@gskbio.com RI Maiden, Martin/C-5055-2014 OI Maiden, Martin/0000-0001-6321-5138 FU Wellcome Trust [087622] NR 23 TC 11 Z9 11 U1 0 U2 2 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2011 VL 10 IS 5 SI SI BP 559 EP 561 DI 10.1586/ERV.11.41 PG 3 WC Immunology SC Immunology GA 779DR UT WOS:000291758800002 PM 21604975 ER PT J AU Regules, JA Cummings, JF Ockenhouse, CF AF Regules, Jason A. Cummings, James F. Ockenhouse, Christian F. TI The RTS,S vaccine candidate for malaria SO EXPERT REVIEW OF VACCINES LA English DT Article DE adjuvant; falciparum; malaria; malaria vaccine; prime-boost RTS,S ID B SURFACE-ANTIGEN; FALCIPARUM CIRCUMSPOROZOITE-PROTEIN; RANDOMIZED CONTROLLED-TRIAL; T-CELL RESPONSES; PHASE 2A TRIAL; PLASMODIUM-FALCIPARUM; MOZAMBICAN CHILDREN; NAIVE ADULTS; SEQUENTIAL IMMUNIZATION; PRECLINICAL EVALUATION AB Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine formulation. Throughout its development, increasingly more effective adjuvants have been key in improving the potency of the vaccine. RTS,S-based vaccine formulations have been demonstrated to be safe, well tolerated, immunogenic, and to confer partial efficacy in both malaria-naive and -experienced adults as well as children. Further research to optimize and improve vaccine efficacy is ongoing. C1 [Regules, Jason A.; Cummings, James F.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Regules, JA (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jason.regules@us.army.mil NR 67 TC 48 Z9 48 U1 4 U2 11 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2011 VL 10 IS 5 SI SI BP 589 EP 599 DI 10.1586/ERV.11.57 PG 11 WC Immunology SC Immunology GA 779DR UT WOS:000291758800010 PM 21604980 ER PT J AU Brown, A Nitayaphan, S AF Brown, Arthur Nitayaphan, Sorachai TI THE ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES: FIVE DECADES OF COLLABORATIVE MEDICAL RESEARCH SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Army; research; tropical disease; Thailand ID JAPANESE ENCEPHALITIS-VIRUS; PLACEBO-CONTROLLED TRIAL; YOUNG THAI MEN; ANTIMALARIAL DRUG SUSCEPTIBILITY; PLASMODIUM-FALCIPARUM MALARIA; LINKED-IMMUNOSORBENT-ASSAY; DENGUE HEMORRHAGIC-FEVER; DISEASE SEVERITY; VACCINE TRIAL; FOREIGN RESIDENTS AB The Armed Forces Research Institute of Medical Sciences (AFRIMS) is a 50-year-old joint institute of the US and Royal Thai Army Medical Departments located in Bangkok, Thailand. Investigators from the Institute have carried out research in Thailand and the region, in collaboration with many partners, focused on a large number of tropical infectious diseases. In celebration of the 50(th) anniversary, this paper summarizes highlights of this research, focusing on malaria, Japanese encephalitis, dengue, diarrhea and HIV. In addition, research done in support of the medical problems of refugees and of the health of Thai peace-keeping forces are summarized. The research carried out by AFRIMS and added to the scientific literature has contributed significantly to advancement in multiple areas of tropical infectious disease. C1 [Brown, Arthur; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Brown, A (reprint author), Armed Forces Res Inst Med Sci, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM Arthur.Brown@afrims.org NR 94 TC 0 Z9 0 U1 0 U2 3 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAY PY 2011 VL 42 IS 3 BP 477 EP 490 PG 14 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 779IZ UT WOS:000291772600001 PM 21706925 ER PT J AU Schaaf, RC Toth-Cohen, S Johnson, SL Outten, G Benevides, TW AF Schaaf, Roseann C. Toth-Cohen, Susan Johnson, Stephanie L. Outten, Gina Benevides, Teal W. TI The everyday routines of families of children with autism Examining the impact of sensory processing difficulties on the family SO AUTISM LA English DT Article DE autism; family; qualitative research; routines; sensory processing ID ASPERGER-SYNDROME; PARENTS; ABNORMALITIES; DISORDERS; STRESS AB The purpose of this qualitative study was to explore the lived experience of how sensory-related behaviors of children with autism affected family routines. In-depth semi-structured interviews were conducted with four primary caregivers regarding the meaning and impact of their child's sensory-related behaviors on family routines that occurred inside and outside the home. Findings indicated that sensory behaviors are one factor that limited family participation in work, family and leisure activities; and that parents employed specific strategies to manage individual and family routines in light of the child's sensory-related behaviors. This information has important implications for professionals who work with families of children with autism to decrease caregiver stress and to increase life satisfaction for the child and family. C1 [Schaaf, Roseann C.; Toth-Cohen, Susan; Benevides, Teal W.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Johnson, Stephanie L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Outten, Gina] Therapy Serv Delaware, Wilmington, DE USA. RP Schaaf, RC (reprint author), Thomas Jefferson Univ, 130 S 9th St,Suite 810, Philadelphia, PA 19107 USA. EM roseann.schaaf@jefferson.edu NR 28 TC 47 Z9 47 U1 3 U2 19 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1362-3613 J9 AUTISM JI Autism PD MAY PY 2011 VL 15 IS 3 BP 373 EP 389 DI 10.1177/1362361310386505 PG 17 WC Psychology, Developmental SC Psychology GA 776MY UT WOS:000291540600009 PM 21430016 ER PT J AU Cui, XF Talley, JW Liu, GJ Larson, SL AF Cui, Xiaofei Talley, Jeffrey W. Liu, Guojing Larson, Steve L. TI Effects of primary sludge particulate (PSP) entrapment on ultrasonic (20 kHz) disinfection of Escherichia coli SO WATER RESEARCH LA English DT Article DE Primary sludge particulates; Ultrasonic disinfection; Entrapment of Escherichia coli; Scanning electron microscopy ID WASTE-WATER DISINFECTION; ANAEROBIC-DIGESTION; ACTIVATED-SLUDGE; ULTRAVIOLET DISINFECTION; SUSPENDED PARTICLES; DIRECT SONICATION; AQUEOUS-SOLUTIONS; ORGANIC-MATTER; SEWAGE-SLUDGE; ACETIC-ACID AB The role of primary sludge particulates (PSPs) in ultrasonic disinfection of Escherichia coli (E. coli) was investigated. Entrapment of E. coli by PSP was directly observed through scanning electron microscope (SEM) after E. coli and PSP were incubated together in water for 24 h at 35 degrees C. Entrapment coefficient was proposed for the first time to reflect the ability of PSP to entrap E. coli and was estimated as 1.4 x 10(3) CFU/mg PSP under our experimental conditions. Ultrasonication (20 kHz) of different E. coli-PSPs solutions showed that the entrapped E. coli cells were protected by PSP from ultrasonication and the unentrapped cells were not. However, the protection of entrapped E. coli cells gradually decreased as ultrasonication proceeded, suggesting the ability of power ultrasonication to deprotect the entrapped E. coli cells. SEM studies suggested a two-step mechanism for ultrasonic (20 kHz) disinfection of entrapped E. coli: breakdown of the protective PSP refugia and disinfection of the exposed E. coli cells. This research will enable more informed decisions about disinfection of aqueous samples where porous PSP are present. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Cui, Xiaofei; Talley, Jeffrey W.] So Methodist Univ, Dept Civil & Environm Engn, Dallas, TX 75205 USA. [Talley, Jeffrey W.] Environm Technol Solut, Gilbert, AZ 85233 USA. [Larson, Steve L.] USA, Corps Engineers, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Talley, JW (reprint author), So Methodist Univ, Dept Civil & Environm Engn, Suite 203,3101 Dyer St, Dallas, TX 75205 USA. EM jtalley@lyle.smu.edu FU Indiana 21st Century Project FX Thanks to Mr. Roy Beavers who has provided great advice on SEM imaging, Dr. Larry Ruben and Mr. Greg Hubbard from the Department of Biological Sciences of Southern Methodist University who have provided the lyophilizer and valuable assistance, Ms. Laurie Muller from Molecular and Cellular Imaging Facilities of University of Texas-Southwestern Medical Center for help in the SEM studies, and Dr. Andrew Quicksall, Mr. Gary Michael Nijak Jr. and Mr. Brian D. Fisher from the Department of Environmental and Civil Engineering of Southern Methodist University for their comments on the paper. We also thank sponsors of the Indiana 21st Century Project for their financial support, and Dallas, TX Central Wastewater Treatment Plant for supply of primary sludge. NR 41 TC 11 Z9 13 U1 1 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD MAY PY 2011 VL 45 IS 11 BP 3300 EP 3308 DI 10.1016/j.watres.2011.03.034 PG 9 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 775YJ UT WOS:000291499100004 PM 21529883 ER PT J AU Autor, DH Duggan, MG Lyle, DS AF Autor, David H. Duggan, Mark G. Lyle, David S. TI Battle Scars? The Puzzling Decline in Employment and Rise in Disability Receipt among Vietnam Era Veterans SO AMERICAN ECONOMIC REVIEW LA English DT Article ID INSURANCE; HEALTH C1 [Autor, David H.] MIT, Dept Econ, Cambridge, MA 02142 USA. [Autor, David H.] Natl Bur Econ Res, Cambridge, MA 02138 USA. [Duggan, Mark G.] Univ Maryland, Dept Econ, College Pk, MD 20742 USA. [Duggan, Mark G.] NBER, Cambridge, MA 02138 USA. [Lyle, David S.] US Mil Acad, Off Econ & Manpower Anal, West Point, NY 10996 USA. RP Autor, DH (reprint author), MIT, Dept Econ, 50 Mem Dr,E52-371, Cambridge, MA 02142 USA. EM dautor@mit.edu; duggan@econ.umd.edu; David.Lyle@usma.edu NR 10 TC 20 Z9 20 U1 0 U2 7 PU AMER ECONOMIC ASSOC PI NASHVILLE PA 2014 BROADWAY, STE 305, NASHVILLE, TN 37203 USA SN 0002-8282 J9 AM ECON REV JI Am. Econ. Rev. PD MAY PY 2011 VL 101 IS 3 BP 339 EP 344 DI 10.1257/aer.101.3.339 PG 6 WC Economics SC Business & Economics GA 771IL UT WOS:000291150300066 ER PT J AU Keshtkar-Jahromi, M Kuhn, JH Christova, I Bradfute, SB Jahrling, PB Bavari, S AF Keshtkar-Jahromi, Maryam Kuhn, Jens H. Christova, Iva Bradfute, Steven B. Jahrling, Peter B. Bavari, Sina TI Crimean-Congo hemorrhagic fever: Current and future prospects of vaccines and therapies SO ANTIVIRAL RESEARCH LA English DT Review DE Crimean-Congo hemorrhagic fever; Bunyavirus; Nairovirus; Priority pathogen; Ribavirin; Antiviral therapy; Viral hemorrhagic fever ID ORAL RIBAVIRIN; NOSOCOMIAL OUTBREAK; CLINICAL PATHOLOGY; BIOLOGICAL WEAPONS; VIRUS-INFECTION; EFFICACY; TURKEY; PATHOGENESIS; IRAN; MANAGEMENT AB Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by CCHF virus (CCHFV), a nairovirus in the family Bunyaviridae. CCHF occurs sporadically in a number of countries in Asia, the Middle East, southeastern Europe and Africa. Patients may develop subclinical to severe hemorrhagic disease, with fatal outcomes in a substantial percentage of cases. Transmission usually occurs through contact with viremic livestock or patients or bites by infected ticks. The number of reported cases has increased in recent years, possibly due to global climatic change and human perturbations of biocenoses that may have led to the migration of tick vectors. There is currently no FDA-approved vaccine or specific antiviral therapy for CCHF. The classification of CCHFV as a WHO Risk Group IV pathogen and the lack of suitable animal models has caused progress in developing new prophylactic and therapeutic measures to be slow. Ribavirin is active against CCHFV in vitro, but its efficacy for human therapy has not been definitively demonstrated by clinical studies. CCHF-immunoglobulin is also in use, but without clear evidence of efficacy. In this article, we review the development of prophylaxis and therapy for CCHF and discuss future prospects for vaccine and drug development. (C) 2011 Published by Elsevier B.V. C1 [Bradfute, Steven B.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Keshtkar-Jahromi, Maryam] Univ Maryland, Union Mem Hosp, Baltimore, MD 21201 USA. [Kuhn, Jens H.; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Christova, Iva] Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU Defense Threat Reduction Agency [0048-09-RD-T]; NIAID [HHSN272200200016I] FX This work was partially supported by the Defense Threat Reduction Agency, Transformational Medical Technologies project number 0048-09-RD-T (to SB). JHK performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200200016I. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army, the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. NR 70 TC 34 Z9 38 U1 2 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD MAY PY 2011 VL 90 IS 2 BP 85 EP 92 DI 10.1016/j.antiviral.2011.02.010 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 771TB UT WOS:000291182500166 PM 21362441 ER PT J AU Rogers, J Costello, M Hepner, D AF Rogers, Jonathan Costello, Mark Hepner, David TI Roll Orientation Estimator for Smart Projectiles Using Thermopile Sensors SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article ID ATTITUDE DETERMINATION; HORIZON; SYSTEM AB The use of inexpensive, commercially available thermopiles sensors for roll orientation estimation of spinning bodies is explored. The sensors convert observed thermal gradients into an electrical signal well suited for onboard data acquisition and real-time signal processing. An environmental model emulating sensor stimulus for a six-degree-of-freedom body is generated given standard atmospheric and typical ground conditions. When sensor characteristics are included, the fully developed model can he used to generate accurate sensor output as a function of Euler angles and altitude. Outputs from the model are then shown to compare favorably with experimental flight data, capturing the predominant and nearly sinusoidal signal variation as the projectile rolls. An extended Kalman filter algorithm is offered, which enables real-time roll angle and roll rate estimation using solely thermopiles as feedback. Example results demonstrate that the algorithm yields reasonably accurate roll information. Finally, a trade study demonstrates that roll error is further mitigated as the number of thermopile sensors is increased. This research shows that thermopiles could be useful in a diverse multisensor constellation as a convenient absolute inertial roll reference. C1 [Rogers, Jonathan; Costello, Mark] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. [Hepner, David] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Rogers, J (reprint author), Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. NR 16 TC 11 Z9 12 U1 0 U2 5 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD MAY-JUN PY 2011 VL 34 IS 3 BP 688 EP 697 DI 10.2514/1.52935 PG 10 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 771XK UT WOS:000291193800004 ER PT J AU Jacobs, RN Markunas, JK Nozaki, C Jaime-Vasquez, M Smith, PJ Benson, JD Pellegrino, J AF Jacobs, R. N. Markunas, J. K. Nozaki, C. Jaime-Vasquez, M. Smith, P. J. Benson, J. D. Pellegrino, J. TI Localized dry-etch substrate thinning for dislocation reduction in heteroepitaxial CdTe/Si(211) SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 27th North American Molecular Beam Epitaxy Conference of the American-Vacuum-Society CY SEP 26-29, 2010 CL Breckenridge, CO SP Amer Vacuum Soc ID CDTE HETEROEPITAXY; CRITICAL THICKNESS; CADMIUM TELLURIDE; EPITAXIAL-GROWTH; HGCDTE; SI; SILICON; MBE AB Threading dislocations are a significant problem for heteroepitaxial growth of thin films on large lattice-mismatched substrates. In the case of HgCdTe thin films on Si, Ge, or GaAs, the molecular beam epitaxy (MBE) of 10-15-mu m-thick CdTe buffer layers has historically played a crucial role in reducing threading dislocation densities to current state-of-the-art levels. In this work, the authors investigate a localized substrate thinning approach and its overall effect on further reducing dislocation densities in the CdTe/Si heteroepitaxial system. In using substrates with regions thinned to thicknesses on the order of the CdTe buffer, the attempt is to reduce the dislocation image force acting from the interface toward the epilayer surface. The authors employ both wet-and dry-etching techniques to create locally back-thinned regions of Si(211) wafers. Localized rather than whole wafer thinning was necessary to maintain sufficient substrate thickness for handling. The opposite sides of the wafers were cleaned using standard techniques prior to CdTe MBE. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to measure epilayer and substrate thicknesses. Using CdTe defect-decoration techniques, a decrease in threading dislocation density by up to 60% has been observed in regions for which the underlying Si substrate was thinned to 2 mu m. Results obtained for wet-etch and dry-etch back-thinning approaches suggest that the dislocation-reduction mechanism is not solely based on substrate-thickness induced image forces. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3547711] C1 [Jacobs, R. N.; Markunas, J. K.; Nozaki, C.; Jaime-Vasquez, M.; Smith, P. J.; Benson, J. D.; Pellegrino, J.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Jacobs, RN (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 22 TC 0 Z9 0 U1 1 U2 3 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY PY 2011 VL 29 IS 3 AR 03C105 DI 10.1116/1.3547711 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 770TL UT WOS:000291111300041 ER PT J AU Sampath, AV Garrett, GA Enck, RW Rottella, P Shen, H Wraback, M AF Sampath, A. V. Garrett, G. A. Enck, R. W. Rottella, P., Jr. Shen, H. Wraback, M. TI Growth of AlGaN containing nanometer scale compositional inhomogeneities for ultraviolet light emitters SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MOLECULAR-BEAM EPITAXY; FILMS; LUMINESCENCE AB The incorporation of nanometer scale compositional inhomogeneities in AlGaN has a great promise for improving the performance of UV light emitting diodes based on these materials by suppressing nonradiative recombination associated with dislocations. In this article, the authors report on the growth and characterization of AlGaN containing nanometer scale compositional inhomogeneity (NCI-AlGaN) alloys deposited by plasma-assisted molecular beam epitaxy. Growth under N-limited and nearly stoichiometric growth is observed to enhance the photoluminescence intensity in AlGaN alloys by promoting the spontaneous formation of these NCI regions. This is attributed to the lower adatom mobility of group III and N species on the AlGaN layer surface under these conditions as well as the formation of beneficial surface faceting. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3585660] C1 [Sampath, A. V.; Garrett, G. A.; Enck, R. W.; Rottella, P., Jr.; Shen, H.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Sampath, AV (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM anand.sampath@us.army.mil NR 11 TC 2 Z9 2 U1 1 U2 4 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY PY 2011 VL 29 IS 3 AR 03C134 DI 10.1116/1.3585660 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 770TL UT WOS:000291111300070 ER PT J AU Zhang, ZL Chatterjee, A Grein, C Ciani, AJ Chung, PW AF Zhang, Zhenli Chatterjee, Alok Grein, Christoph Ciani, Anthony J. Chung, Peter W. TI Atomic-scale modeling of InxGa1-xN quantum dot self-assembly SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MOLECULAR-BEAM EPITAXY; GROWTH; GAN; DYNAMICS; NITRIDE AB The authors simulate in three dimensions the molecular beam epitaxial growth of InxGa1-xN with classical molecular dynamics. Atomic interactions are simulated with Stillinger-Weber potentials. Both homoepitaxial and heteroepitaxial growths are studied. The effects of substrate temperature and indium concentration on quantum dot morphology, concentration profiles, and the thickness of wetting layers qualitatively agree with experimental findings. The authors' simulations support earlier suggestions that quantum dot formation in the InGaN/GaN system is governed by a stress-driven phase separation mechanism. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3579462] C1 [Zhang, Zhenli; Chatterjee, Alok; Grein, Christoph] Sivananthan Labs Inc, Bolingbrook, IL 60440 USA. [Ciani, Anthony J.; Chung, Peter W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, ZL (reprint author), Sivananthan Labs Inc, Bolingbrook, IL 60440 USA. EM zzhang@sivananthanlabs.us FU U.S. Army Research Laboratory [W911QX-07-C-0092] FX This work was supported by the U.S. Army Research Laboratory under Contract No. W911QX-07-C-0092. Computing resources are gratefully acknowledged from the DoD Supercomputing Resource Center at the U. S. Army Research Laboratory. NR 24 TC 2 Z9 2 U1 2 U2 16 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY PY 2011 VL 29 IS 3 AR 03C133 DI 10.1116/1.3579462 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 770TL UT WOS:000291111300069 ER PT J AU Fraser, S AF Fraser, Shanna TI HERNIA BELT ... STAT! SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING LA English DT Meeting Abstract C1 [Fraser, Shanna] Brooke Army Med Ctr, Schertz, TX USA. EM shanna.fraser@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1071-5754 J9 J WOUND OSTOMY CONT JI J. Wound Ostomy Cont. Nurs. PD MAY-JUN PY 2011 VL 38 IS 3 SU S MA 5302 BP S65 EP S65 PG 1 WC Nursing SC Nursing GA 772LI UT WOS:000291235000182 ER PT J AU Hernandez, M AF Hernandez, Maxwell TI HOSPITAL-ACQUIRED PRESSURE ULCERS AND SKIN CARE: IMPROVING NURSING STAFF EFFECTIVENESS SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING LA English DT Meeting Abstract C1 [Hernandez, Maxwell] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM maxwell.hernandez@us.army.mil NR 5 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1071-5754 J9 J WOUND OSTOMY CONT JI J. Wound Ostomy Cont. Nurs. PD MAY-JUN PY 2011 VL 38 IS 3 SU S MA 5285 BP S59 EP S59 PG 1 WC Nursing SC Nursing GA 772LI UT WOS:000291235000165 ER PT J AU Madore, A AF Madore, Alicia TI JOINT SERVICE INITIATIVE: OPERATIONAL ADVANCED WOUND CARE FORMULARY AND GUIDELINE SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING LA English DT Meeting Abstract C1 [Madore, Alicia] Walter Reed Army Med Ctr, Springfield, VA USA. EM alicia.madore@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1071-5754 J9 J WOUND OSTOMY CONT JI J. Wound Ostomy Cont. Nurs. PD MAY-JUN PY 2011 VL 38 IS 3 SU S MA 5201 BP S30 EP S30 PG 1 WC Nursing SC Nursing GA 772LI UT WOS:000291235000081 ER PT J AU Barnes, TA Kacmarek, RM Kageler, WV Morris, MJ Durbin, CG AF Barnes, Thomas A. Kacmarek, Robert M. Kageler, Woody V. Morris, Michael J. Durbin, Charles G., Jr. TI Transitioning the Respiratory Therapy Workforce for 2015 and Beyond SO RESPIRATORY CARE LA English DT Article DE respiratory care; respiratory therapist; manpower; education; training; competency; licensure; credentialing; accreditation; credentials; specialty; protocols ID MECHANICAL VENTILATION; CARDIAC-ARREST; EDUCATION; CARE AB The American Association for Respiratory Care established a task force in late 2007 to identify likely new roles and responsibilities of respiratory therapists (RTs) in the year 2015 and beyond. A series of 3 conferences was held between 2008 and 2010. The first task force conference affirmed that the healthcare system is in the process of dramatic change, driven by the need to improve health while decreasing costs and improving quality. This will be facilitated by application of evidence-based care, prevention and management of disease, and closely integrated interdisciplinary care teams. The second task force conference identified specific competencies needed to assure safe and effective execution of RT roles and responsibilities in the future. The third task force conference was charged with creating plans to change the professional education process so that RTs are able to achieve the needed skills, attitudes, and competencies identified in the previous conferences. Transition plans were developed by participants after review and discussion of the outcomes of the first two conferences and 1,011 survey responses from RT department managers and RT education program directors. This is a report of the recommendations of the third task force conference held July 12-14, 2010, on Marco Island, Florida. The participants, who represented groups concerned with RT education, licensure, and practice, proposed, discussed, and accepted that to be successful in the future a baccalaureate degree must be the minimum entry level for respiratory care practice. Also accepted was the recommendation that the Certified Respiratory Therapist examination be retired, and instead, passing of the Registered Respiratory Therapist examination will be required for beginning clinical practice. A date of 2020 for achieving these changes was proposed, debated, and accepted. Recommendations were approved requesting resources be provided to help RT education programs, existing RT workforce, and state societies work through the issues raised by these changes. C1 [Barnes, Thomas A.] Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA. [Kacmarek, Robert M.] Massachusetts Gen Hosp, Dept Anesthesiol, Boston, MA 02114 USA. [Kacmarek, Robert M.] Harvard Univ, Sch Med, Boston, MA USA. [Kageler, Woody V.] Tarrant Cty Coll, Dept Hlth Sci, Ft Worth, TX USA. [Morris, Michael J.] Brooke Army Med Ctr, Dept Internal Med, San Antonio, TX USA. [Durbin, Charles G., Jr.] Univ Virginia, Dept Anesthesiol, Charlottesville, VA USA. RP Barnes, TA (reprint author), Northeastern Univ, Dept Hlth Sci, 316 Robinson Hall,360 Huntington Ave, Boston, MA 02115 USA. EM tbarnes@neu.edu NR 29 TC 13 Z9 14 U1 1 U2 4 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD MAY PY 2011 VL 56 IS 5 BP 681 EP 690 DI 10.4187/respcare.01169 PG 10 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 771XO UT WOS:000291194200015 PM 21276324 ER PT J AU Niebuhr, DW Li, YZ Cowan, DN Weber, NS Fisher, JA Ford, GM Yolken, R AF Niebuhr, David W. Li, Yuanzhang Cowan, David N. Weber, Natalya S. Fisher, Jared A. Ford, Glen M. Yolken, Robert TI Association between bovine casein antibody and new onset schizophrenia among US military personnel SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Hazard ratio; Serum; Immunoglobulin G; Pre-onset; Diet ID BIPOLAR DISORDER; WHEAT GLUTEN; MILK; HYPOTHESIS; PSYCHOSIS AB Schizophrenia is a pervasive neuropsychiatric disorder of uncertain etiology. Multiple studies have documented immune activation in individuals with schizophrenia. One antigen capable of inducing a prolonged immune response is bovine casein derived from ingested milk products. Increased levels of casein antibodies have been found in individuals with schizophrenia after diagnosis. This study was directed at determining the potential association between schizophrenia and pre-illness onset levels of immunoglobulin G (IgG) antibodies to bovine casein. Parallel analyses for casein antibody levels with bipolar disorder were included as comparison. Cases were service members who received medical discharges from the military with a schizophrenia diagnosis from 1992 to 2005. Serum specimens were selected for 855 cases and 1165 matched healthy controls. IgG antibodies to bovine whole-casein were measured by solid phase enzyme-linked immunosorbent assays (ELISAs). Hazard ratios (HR) were calculated to examine the associations of casein IgG level with risk of schizophrenia by time to diagnosis and by subjects' initial level. Increasing casein IgG antibody levels among those with a high initial level, drawn before diagnosis, was associated with an 18% increase in the hazard risk of schizophrenia per unit increase (value of low-positive standard) in IgG antibody levels (HR = 1.18; 95% CI 1.04, 1.34). This is the first report to identify an association between the risk of schizophrenia and elevated antibodies to bovine casein prior to disease onset. Additional research is required to elucidate the complex genetic environmental interactions involved in the pathogenesis of schizophrenia and to identify potentially modifiable risk factors. Published by Elsevier B.V. C1 [Niebuhr, David W.; Li, Yuanzhang; Cowan, David N.; Weber, Natalya S.; Fisher, Jared A.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Cowan, David N.; Fisher, Jared A.] Allied Technol Grp Inc, Rockville, MD 20850 USA. [Ford, Glen M.] BioAssay Works LLC, Ijamsville, MD 21754 USA. [Yolken, Robert] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM David.Niebuhr@us.army.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU Stanley Medical Research Institute, Bethesda, MD; Department of the Army FX This work was funded by the Stanley Medical Research Institute, Bethesda, MD, and the Department of the Army. The funding organizations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army or Department of Defense. NR 22 TC 17 Z9 17 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD MAY PY 2011 VL 128 IS 1-3 BP 51 EP 55 DI 10.1016/j.schres.2011.02.005 PG 5 WC Psychiatry SC Psychiatry GA 771QL UT WOS:000291175700010 PM 21376538 ER PT J AU Kiris, E Nuss, JE Burnett, JC Kota, KP Koh, DC Wanner, LM Torres-Melendez, E Gussio, R Tessarollo, L Bavari, S AF Kiris, Erkan Nuss, Jonathan E. Burnett, James C. Kota, Krishna P. Koh, Dawn C. Wanner, Laura M. Torres-Melendez, Edna Gussio, Rick Tessarollo, Lino Bavari, Sina TI Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery SO STEM CELL RESEARCH LA English DT Article ID SYNAPTIC PROTEIN SNAP-25; MOTOR-NEURONS; SPINAL-CORD; DIRECTED DIFFERENTIATION; CLOSTRIDIAL NEUROTOXINS; TERMINAL DOMAIN; TOXIN; RECEPTOR; PERSISTENCE; TRANSLOCATION AB Botulinum neurotoxins (BoNTs) inhibit cholinergic synaptic transmission by specifically cleaving proteins that are crucial for neurotransmitter exocytosis. Due to the lethality of these toxins, there are elevated concerns regarding their possible use as bioterrorism agents. Moreover, their widespread use for cosmetic purposes, and as medical treatments, has increased the potential risk of accidental overdosing and environmental exposure. Hence, there is an urgent need to develop novel modalities to counter BoNT intoxication. Mammalian motoneurons are the main target of BoNTs; however, due to the difficulty and poor efficiency of the procedures required to isolate the cells, they are not suitable for high-throughput drug screening assays. Here, we explored the suitability of embryonic stem (ES) cell-derived motoneurons as a renewable, reproducible, and physiologically relevant system for BoNT studies. We found that the sensitivity of ES-derived motoneurons to BoNT/A intoxication is comparable to that of primary mouse spinal motoneurons. Additionally, we demonstrated that several BoNT/A inhibitors protected SNAP-25, the BoNT/A substrate, in the ES-derived motoneuron system. Furthermore, this system is compatible with immunofluorescence-based high-throughput studies. These data suggest that ES-derived motoneurons provide a highly sensitive system that is amenable to large-scale screenings to rapidly identify and evaluate the biological efficacies of novel therapeutics. Published by Elsevier B.V. C1 [Kiris, Erkan; Nuss, Jonathan E.; Kota, Krishna P.; Wanner, Laura M.; Torres-Melendez, Edna; Bavari, Sina] USA, Med Res Inst Infect Dis, Dept Target Discovery & Expt Microbiol, Frederick, MD 21702 USA. [Kiris, Erkan; Koh, Dawn C.; Tessarollo, Lino] NCI, Neural Dev Grp, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA. [Burnett, James C.] NCI, SAIC Frederick Inc, TSBDDG, Frederick, MD 21702 USA. [Burnett, James C.; Gussio, Rick] NCI, TSBDDG, Informat Technol Branch, Dev Therapeut Program, Frederick, MD USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Dept Target Discovery & Expt Microbiol, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil FU Defense Threat Reduction Agency [CBS.MEDBIO_01_10_RD_014]; National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX We are indebted to Dr. Thomas M. Jessell and Dr. Hynek Wichterle (Columbia University, New York, NY) for the generous gift of HBG3 mouse ES cell line. Also, we are grateful to Eileen Southon for kindly providing mouse embryonic fibroblast cells and helping with stem cell culture, Jodi Becker for providing assistance with microscopy and mouse spinal cord dissections, and Lyal Tressler for providing assistance with Li-Cor studies. Additionally, we thank the members of the Tessarollo, Gussio, and Bavari labs for their insightful discussion and generosity. This work was supported by Defense Threat Reduction Agency (CBS.MEDBIO_01_10_RD_014). Furthermore, for J.C.B., this project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. NR 59 TC 22 Z9 22 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1873-5061 J9 STEM CELL RES JI Stem Cell Res. PD MAY PY 2011 VL 6 IS 3 BP 195 EP 205 DI 10.1016/j.scr.2011.01.002 PG 11 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 773GU UT WOS:000291295800001 PM 21353660 ER PT J AU Lehmann, RK Brounts, LR Johnson, EK Rizzo, JA Steele, SR AF Lehmann, Ryan K. Brounts, Lionel R. Johnson, Eric K. Rizzo, Julie A. Steele, Scott R. TI Does sacrifice of the inferior mesenteric artery or superior rectal artery affect anastomotic leak following sigmoidectomy for diverticulitis? a retrospective review SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Sigmoid colectomy; Diverticulitis; Anastomotic leak; Inferior mesenteric artery ID COLORECTAL RESECTION; DISEASE; SURGERY; COLECTOMY; COLON AB BACKGROUND: Anastomotic leak after sigmoidectomy for diverticular disease can have devastating consequences. Preservation or sacrifice of the descending colon or rectal arterial supply may affect the anastomosis. The aim of this study was to evaluate whether preservation of the inferior mesenteric artery (IMA) or superior rectal artery (SRA) was associated with a decreased anastomotic leak rate. METHODS: A retrospective review of adult patients undergoing sigmoidectomies from 2 military tertiary care centers was performed, evaluating patient demographic and operative variables for their effects on anastomotic leak rate. RESULTS: A total of 130 patients were identified. The overall anastomotic leak rate was 5.4%. Laparoscopy was used in 41%, and stapled anastomoses were used in 91%. The IMA was sacrificed in 29% and the SRA in 37%. There were no significant differences in leak rates when the IMA or SRA was sacrificed (0% and 3.7% with the IMA and SRA sacrificed, 9.3% and 6.5% with the vessels preserved; P = .140 and P = .610, respectively). Laparoscopic technique (P = .843), emergency surgery (P = .29), and operative time (P = .78) did not affect leak rate. Hand-sewn anastomoses were associated with a higher leak rate (33% vs 2%; odds ratio, 3.44; 95% confidence interval, 1.514-7.817; P < .001). CONCLUSIONS: IMA or SRA preservation or sacrifice was not associated with an increased leak rate from colorectal anastomoses after sigmoidectomy for diverticular disease. Stapled anastomoses were associated with a lower leak rate than hand-sewn anastomoses. Published by Elsevier Inc. C1 [Lehmann, Ryan K.; Brounts, Lionel R.; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Johnson, Eric K.; Rizzo, Julie A.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. RP Steele, SR (reprint author), Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. EM harkersteele@mac.com NR 19 TC 2 Z9 2 U1 0 U2 3 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD MAY PY 2011 VL 201 IS 5 BP 619 EP 623 DI 10.1016/j.amjsurg.2011.01.011 PG 5 WC Surgery SC Surgery GA 768PV UT WOS:000290948800017 ER PT J AU Conti, G Babbbbitt, T Nelson, J AF Conti, Gregory Babbbbitt, Thomas Nelson, John TI Hacking Competitions and Their Untapped Potential for Security Education SO IEEE SECURITY & PRIVACY LA English DT Article DE computer security education; hacking; hacking competitions; computer security; security and privacy; hacker conferences; capture the flag C1 [Conti, Gregory; Babbbbitt, Thomas] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Nelson, John] US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA. RP Conti, G (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM gregory.conti@usma.edu; babbitt@usma.edu; john.nelson@usma.edu NR 10 TC 4 Z9 4 U1 0 U2 7 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD MAY-JUN PY 2011 VL 9 IS 3 BP 56 EP 59 DI 10.1109/MSP.2011.51 PG 4 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 769GJ UT WOS:000290999800010 ER PT J AU Choi, KK Jhabvala, MD Forrai, DP Sun, J Endres, D AF Choi, K. K. Jhabvala, M. D. Forrai, D. P. Sun, J. Endres, D. TI C-QWIPs for space exploration SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on the Quantum Structure Infrared Photodector (QSIP) CY AUG 15-20, 2010 CL Istanbul, TURKEY DE QWIP; FPA; NE Delta T ID WELL INFRARED PHOTODETECTORS AB We have extended our investigation of corrugated quantum well infrared photodetector focal plane arrays (C-QWIP FPAs) into the far infrared regime. Specifically, we are developing the detectors for the thermal infrared sensor (TIRS) used in the NASA Landsat Data Continuity Mission. This mission requires infrared detection cutoff at 12.5 mu m and FPAs operated at similar to 43 K. To maintain a low dark current in these extended wavelengths, we adopted a low doping density of 0.6 x 10(18) cm(-3) and a bound-to-bound state detector in one of the designs. The internal absorption quantum efficiency eta is calculated to be 25.4% for a pixel pitch of 25 mu m and 60 periods of QWs. With a pixel fill factor of 80% and a substrate transmission of 70.9%, the external eta is 14.4%. To yield the theoretical conversion efficiency CE, the photoconductive gain was measured and is 0.25 at 5 V. from which CE is predicted to be 3.6%. This value is in agreement with the 3.5% from the FPA measurement. Meanwhile, the dark current is measured to be 2.1 x 10(-6) A/cm(2) at 43 K. For regular infrared imaging above 8 gm, the FPA will have a noise equivalent temperature difference (NETD) of 16 mK at 2 ms integration time in the presence of 260 read noise electrons, and it increases to 22 mK at 51 K. The highest operability of the tested FPAs is 99.967%. With the CE agreement, we project the FPA performance in the far infrared regime up to 30-gm cutoff, which will be useful for the Jupiter-Europa deep space exploration. In this work, we also investigated the C-QWIP optical coupling when the detector substrate is thinned. Published by Elsevier B.V. C1 [Choi, K. K.; Sun, J.] USA, Res Lab, Adelphi, MD 20783 USA. [Jhabvala, M. D.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Forrai, D. P.; Endres, D.] L3 Cincinnati Elect, Mason, OH 45040 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kwongkit.choi@us.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 5 TC 1 Z9 2 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2011 VL 54 IS 3 BP 170 EP 176 DI 10.1016/j.infrared.2010.12.006 PG 7 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 768XP UT WOS:000290973200005 ER PT J AU Bandara, S Maloney, P Baril, N Pellegrino, J Tidrow, M AF Bandara, Sumith Maloney, Patrick Baril, Neil Pellegrino, Joseph Tidrow, Meimei TI Performance of InAs/GaSb superlattice infrared detectors and dependence on minority carrier lifetime SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on the Quantum Structure Infrared Photodector (QSIP) CY AUG 15-20, 2010 CL Istanbul, TURKEY DE Long wavelength; Infrared; Focal plane arrays; Strained-layer superlattice AB This paper will discuss the desired quantum efficiency and dark current density of type-II strained-layer superlattice detectors (T2SLS), and required read-noise levels for long-wavelength infrared (LWIR) imaging applications at various background levels. The computation begins with noise equivalent irradiance NEI requirements with the focal plane array (FPA) operating at near-background limited infrared photodetection (BLIP) performance conditions. The paper will theoretically analyze the quantum efficiency and the dark current based on various components such as: diffusion, generation-recombination and tunneling, and dependence on the minority carrier lifetime of T2SL detector material. These calculations show appropriate minority carrier lifetime of the detector material for the various flux levels discussed in the article. Published by Elsevier B.V. C1 [Bandara, Sumith; Maloney, Patrick; Baril, Neil; Pellegrino, Joseph; Tidrow, Meimei] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Bandara, S (reprint author), USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. EM sumith.bandara@us.army.mil NR 16 TC 9 Z9 9 U1 3 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2011 VL 54 IS 3 BP 263 EP 266 DI 10.1016/j.infrared.2010.12.026 PG 4 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 768XP UT WOS:000290973200023 ER PT J AU Knapik, JJ Hauret, KG Canada, S Marin, R Jones, B AF Knapik, Joseph J. Hauret, Keith G. Canada, Sara Marin, Roberto Jones, Bruce TI Association Between Ambulatory Physical Activity and Injuries During United States Army Basic Combat Training SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE pedometer; fitness; body mass index ID RUNNING INJURIES; MUSCULOSKELETAL INJURIES; RISK-FACTORS; YOUNG MEN; RUNNERS; FITNESS; EPIDEMIOLOGY; EXERCISE; ADULTS; POPULATION AB Background: Associations between physical activity and injuries have been previously examined using self-reports. The present investigation examined this association using objective measures of activity and injury. Methods: To quantify ambulatory activity, pedometers were worn daily by recruits in 10 Army Basic Combat Training companies during the 9-week training cycle. Injuries were obtained from a medical surveillance system, defined as traumatic or overuse events resulting in a medical care provider visit. A daily questionnaire documented whether or not recruits wore the pedometers and trained with their companies for the entire day. Results: Training companies were categorized by activity level into 3 groups with higher activity (HA, 17,948 +/- 550 steps/day), 4 with moderate activity (MA, 16,346 +/- 768 steps/day) and 3 with lower activity (LA, 14,772 +/- 400 steps/day). Among men, the MA and HA groups were at 1.52 (95% confidence interval [95% CI] = 1.15-2.01) and 1.94 (95% CI = 1.46-2.61) times higher injury risk, respectively, compared with the LA group. Among women, the MA and HA groups were at 1.36 (95% CI = 1.07-1.73) and 1.53 (95% CI = 1.24-1.89) times higher injury risk, respectively, compared with low LA group. The relationships remained significant after considering physical characteristics and physical fitness. Conclusions: In consonance with previous self-report studies, higher physical activity was associated with higher injury risk. C1 [Knapik, Joseph J.; Hauret, Keith G.; Jones, Bruce] USA, Dept Injury Prevent, Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA. [Canada, Sara] Towson Univ, Towson, MD USA. [Marin, Roberto] Womack Army Med Ctr, Dept Occupat Med, Ft Bragg, NC USA. RP Knapik, JJ (reprint author), USA, Dept Injury Prevent, Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA. NR 38 TC 15 Z9 16 U1 1 U2 4 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD MAY PY 2011 VL 8 IS 4 BP 496 EP 502 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 768YD UT WOS:000290974900006 PM 21597122 ER PT J AU Bromberg, L Straut, CM Centrone, A Wilusz, E Hatton, TA AF Bromberg, Lev Straut, Christine M. Centrone, Andrea Wilusz, Eugene Hatton, T. Alan TI Montmorillonite Functionalized with Pralidoxime As a Material for Chemical Protection against Organophosphorous Compounds SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE montmorillonite K-10; pyridine-2-aldoxime methiodide; functionalization; organophosphate hydrolysis; protective barrier ID ORGANOTHIOPHOSPHATE PESTICIDE; METHYL PARATHION; LEWIS ACIDITY; MODIFIED CLAY; ADSORPTION; BEHAVIOR; WATER; HYDROLYSIS; OXIMATE; POLYMERIZATION AB Montmorillonite K-10 functionalized with a-nucleophilic 2-pralidoxime (PAM) and its zwitterionic oximate form (PAMNa) is introduced as a versatile material for chemical protection against organophosphorous (OP) compounds such as pesticides and chemical warfare agents (CWA). Upon inclusion into the montmorillonite interlayer structure, the pyridinium group of PAMNa is strongly physisorbed onto acidic sites of the clay, leading to shrinking of the interplanar distance. Degradation of diethyl parathion by PAMNa-functionalized montmorillonite in aqueous-acetonitrile solutions occurred primarily via hydrolytic conversion of parathion into diethylthio phosphoric acid, with the initial stages of hydrolysis observed to be pseudo-first-order reactions. Hydrolysis catalyzed by the clay intercalated by PAMNa was 10- and 17-fold more rapid than corresponding spontaneous processes measured at 25 and 70 degrees C, respectively. Hydrolytic degradation of diisopropyl fluorophosphate (DFP), a CWA simulant, was studied on,montmorillonite clay functionalized by PAMNa and equilibrated with water vapor at 100% relative humidity by (31)P high-resolution magic angle spinning NMR and was observed to be rather facile compared with the untreated montmorillonite, which did not show any DFP hydrolysis within 24 h. The incorporation of the functionalized clay particles into elastomeric film of polyisobutylene was shown to be a means to impart DFP-degrading capability to the film, with clay particle content exceeding 18 wt %. C1 [Bromberg, Lev; Centrone, Andrea; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Straut, Christine M.] Battelle Natick Operat, Natick, MA 01760 USA. [Wilusz, Eugene] US Army Natick Soldier Res, Ctr Dev & Engn, Mat & Def Sci Div, Natick, MA 01760 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM tahatton@mit.edu RI Centrone, Andrea/H-5541-2013 FU Defense Threat Reduction Agency [HDTRA1-09-1-0012] FX The authors were supported by the Defense Threat Reduction Agency, in part by Grant HDTRA1-09-1-0012. NR 31 TC 19 Z9 19 U1 7 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY PY 2011 VL 3 IS 5 BP 1479 EP 1484 DI 10.1021/am200041e PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 767GR UT WOS:000290843800017 PM 21438604 ER PT J AU Cardellina, JH Vieira, RC Eccard, V Skerry, J Montgomery, V Campbell, Y Roxas-Duncan, V Leister, W LeClair, CA Maloney, DJ Padula, D Pescitelli, G Khavrutskii, I Hu, X Wallqvist, A Smith, LA AF Cardellina, John H., II Vieira, Rebecca C. Eccard, Vanessa Skerry, Janet Montgomery, Vicki Campbell, Yvette Roxas-Duncan, Virginia Leister, William LeClair, Christopher A. Maloney, David J. Padula, Daniele Pescitelli, Gennaro Khavrutskii, Ilja Hu, Xin Wallqvist, Anders Smith, Leonard A. TI Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Chiral resolution; Betti reaction products; TDDFT CD calculations; molecular docking; inhibition of botulinum neurotoxin ID AUTOMATED DOCKING; FLEXIBLE LIGANDS; INVERSION; BASE; IBUPROFEN; ENERGIES; PROTEASE; AUTODOCK; SEROTYPE; KEY AB The racemic product of the Betti reaction of 5-chloro-8-hydroxyquinoline, benzaldehyde, and 2-aminopyridine was separated by chiral HPLC to determine which enantiomer inhibited botulinurn neurotoxin serotype A. When the enantiomers unexpectedly proved to have comparable activity, the absolute structures of (+)-(R)-1 and ()-(S)-1 were determined by comparison of calculated and observed circular dichroism spectra. Molecular modeling studies were undertaken in an effort to understand the observed bioactivity and revealed different ensembles of binding modes, with roughly equal binding energies, for the two enantiomers. C1 [Smith, Leonard A.] USA, Off Chief Scientist, Med Res Inst Infect Dis, Frederick, MD USA. [Cardellina, John H., II; Vieira, Rebecca C.; Eccard, Vanessa; Skerry, Janet; Montgomery, Vicki; Campbell, Yvette; Roxas-Duncan, Virginia] USA, Div Integrated Toxicol, Med Res Inst Infect Dis, Frederick, MD USA. [Leister, William; LeClair, Christopher A.; Maloney, David J.] NHGRI, NIH Chem Genom Ctr, NIH, Bethesda, MD 20892 USA. [Padula, Daniele; Pescitelli, Gennaro] Univ Pisa, Dept Chem, Pisa, Italy. [Khavrutskii, Ilja; Hu, Xin; Wallqvist, Anders] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Frederick, MD USA. RP Smith, LA (reprint author), USA, Off Chief Scientist, Med Res Inst Infect Dis, Frederick, MD USA. EM Leonard.Smith@amedd.army.mil RI Pescitelli, Gennaro/G-3536-2010; Padula, Daniele/F-2866-2012; OI Pescitelli, Gennaro/0000-0002-0869-5076; Padula, Daniele/0000-0002-7171-7928; wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency [3.10037_07_RD_B]; National Research Council; U.S. Department of Defense under High Performance Computing Software Applications Institutes (HSAI) initiative FX This work was supported by a grant to L.A.S. from the Defense Threat Reduction Agency, JSTO-CBD Project Number 3.10037_07_RD_B. R.C.V. was funded by a National Research Council Research Associateship Award. This work was sponsored by the U.S. Department of Defense High Performance Computing Modernization Program (HPCMP), under the High Performance Computing Software Applications Institutes (HSAI) initiative. We thank James Bougie for help with the chiral HPLC separation. Opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Department of Defense. NR 28 TC 4 Z9 4 U1 0 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD MAY PY 2011 VL 2 IS 5 BP 396 EP 401 DI 10.1021/ml200028z PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 765GE UT WOS:000290691400014 PM 22102940 ER PT J AU Herr, MW Sheridan, MF AF Herr, Marc W. Sheridan, Mark F. TI Pathology Quiz Case 2 Adenocarcinoma of the colon with metastasis to the thyroid gland (TM) SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID CANCER C1 [Herr, Marc W.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Herr, MW (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAY PY 2011 VL 137 IS 5 BP 527 EP + PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 764MC UT WOS:000290632600018 PM 21576569 ER PT J AU Meyerhoff, J Chakraborty, N di Lima, T Hammamieh, R Calhoun, M Muhie, S Lumley, L Jett, M AF Meyerhoff, James Chakraborty, Nabarun di Lima, Thereza Hammamieh, Rasha Calhoun, Michael Muhie, Seid Lumley, Lucille Jett, Marti TI Social Stress Reduces mPFC Volume and Length of Dendritic Spines SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 66th Annual Meeting of the Society-of-Biological-Psychiatry CY MAY 12-14, 2011 CL San Francisco, CA SP Soc Biol Psychiat C1 [Meyerhoff, James; Chakraborty, Nabarun; Hammamieh, Rasha; Muhie, Seid; Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD USA. [di Lima, Thereza] Univ Fed Santa Catarina, Dept Farmacol, Florianopolis, SC, Brazil. [Calhoun, Michael] Sing Syst Inc, Mol Pathol, Columbia, MD USA. [Lumley, Lucille] US Army, Dept Neurobehav Toxicol, Med Res Inst Chem Def, Aberdeen, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2011 VL 69 IS 9 SU S MA 102 BP 27S EP 27S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 764OR UT WOS:000290641800087 ER PT J AU Farley, J Smith, LM Darcy, KM Brady, MF Bell, J McGuire, W Birrer, MJ AF Farley, John Smith, Leia M. Darcy, Kathleen M. Brady, Mark F. Bell, Jeffrey McGuire, William Birrer, Michael J. TI Nuclear P27 expression in benign, borderline (LMP) and invasive tumors of the ovary and its association with prognosis: A gynecologic oncology group study SO GYNECOLOGIC ONCOLOGY LA English DT Article DE p27; Ovary; Carcinogenesis; Prognostic; Immunohistochemistry ID DEPENDENT KINASE INHIBITOR; CELL-CYCLE REGULATORS; BREAST-CANCER CELLS; P27(KIP1) EXPRESSION; GROWTH ARREST; SUBCELLULAR-LOCALIZATION; SURVIVAL; D1; MALIGNANCY; MUTATIONS AB Objective. Nuclear p27 expression was examined in non-invasive and invasive ovarian tumors from a cross-sectional study, and clinical relevance of p27 was evaluated in the primary tumors from women participating in two randomized phase III treatment trials. Methods. An immunohistochemistry assay was used to detect p27 in formalin-fixed paraffin-embedded ovarian tumors from 3 distinct sources. Results. Among the initial 91 ovarian tumors tested, low p27 expression (< 50% positive cells) was observed in 5.4% of non-invasive tumors versus 42.6% of invasive tumors (p < 0.001). In 145 ovarian cancers with high-risk early stage disease, 16.5% exhibited low p27 expression, and categorized p27 was not associated with age, race, or performance status. Low expression of p27 was common in poorly differentiated tumors (35.7%) compared to moderately (15.0%) and well (9.5%) differentiated tumors (p = 0.024) and rare in clear cell carcinomas (2.4%) compared to other histologies (p = 0.014). In the 139 cancers with advanced disease, 60% displayed low p27 expression, and categorized p27 expression was not associated with age, race, performance status, tumor grade, histologic subtype, measurable disease status or survival. Exploratory analyses revealed an association of cyclin E to p27 ratio > 1.0 with an increased risk of death (hazard ratio = 1.53; p = 0.017). Conclusions. Low p27 expression could be associated with malignant transformation of the ovarian epithelium and FIGO stage. A cyclin E to p27 ratio > 1.0 may be associated with shorter survival in these patients. Further study is required to confirm the trend for increased recurrences with low p27 expression in early stage disease. (C) 2010 Published by Elsevier Inc. C1 [Birrer, Michael J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Farley, John] Walter Reed Army Med Ctr, Dept Obstet Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Smith, Leia M.] Seattle Genet Inc, Seattle, WA 98021 USA. [Darcy, Kathleen M.; Brady, Mark F.] Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. [Bell, Jeffrey] Riverside Methodist Hosp, Columbus, OH 43214 USA. [McGuire, William] Franklin Sq Hosp, Baltimore, MD 21237 USA. [Birrer, Michael J.] Harvard Canc Ctr, Boston, MA 02114 USA. [Birrer, Michael J.] Harvard Univ, Sch Med, Boston, MA 02114 USA. RP Birrer, MJ (reprint author), Massachusetts Gen Hosp, Yawkey 9,55 Fruit St, Boston, MA 02114 USA. EM mbirrer@partners.org FU National Cancer Institute; GOG Tissue Bank [CA 27469]; GOG Statistical and Data Center [CA 37517]; National Cancer Institute of the National Institute of Health FX This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office and the GOG Tissue Bank (CA 27469), the GOG Statistical and Data Center (CA 37517), and the Intramural Research Program of the National Cancer Institute of the National Institute of Health. The following GOG member institutions participated in this study: University of Alabama at Birmingham, Oregon Health Sciences University, Abington Memorial Hospital, University of Rochester Medical Center, Walter Reed Army Medical Center, Wayne State University, University of Southern California at Los Angeles, Colorado Gynecologic Oncology Group, PC, University of California at Los Angeles, University of Washington, Milton S. Hershey Medical Center, Georgetown University Hospital, Wake Forest University School of Medicine, University of California Medical Center at Irvine, Stanford University Medical Center, University of Kentucky, The Cleveland Clinic Foundation, Johns Hopkins Oncology Center, East:ern Pennsylvania GYN/ONC Center, PC, Washington University School of Medicine, Cooper Hospital/University Medical Center, Columbus Cancer Council, University of Massachusetts Medical Center, University of Oklahoma, and Tacoma General Hospital. NR 39 TC 6 Z9 6 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY 1 PY 2011 VL 121 IS 2 BP 395 EP 401 DI 10.1016/j.ygyno.2010.11.023 PG 7 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 760AD UT WOS:000290292100029 PM 21310472 ER PT J AU Han, JJ Yu, MS Houston, N Steinberg, SM Kohn, EC AF Han, Jasmine J. Yu, Minshu Houston, Nicole Steinberg, Seth M. Kohn, Elise C. TI Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers (vol 120, pg 5, 2011) SO GYNECOLOGIC ONCOLOGY LA English DT Correction C1 [Han, Jasmine J.; Yu, Minshu; Houston, Nicole; Kohn, Elise C.] NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Han, Jasmine J.] NCI, Walter Reed Army Med Ctr, Gynecol Malignancies Lab, Bethesda, MD 20892 USA. [Steinberg, Seth M.] NCI, Biostat & Data Management Sect, Ctr Canc Res, Bethesda, MD 20892 USA. RP Kohn, EC (reprint author), NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. EM Kohne@mail.nih.gov NR 1 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY 1 PY 2011 VL 121 IS 2 BP 427 EP 427 DI 10.1016/j.ygyno.2010.12.324 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 760AD UT WOS:000290292100040 ER PT J AU Hause, T AF Hause, Terry TI Advanced functionally graded plate-type structures impacted by blast loading SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Functionally graded; Dynamic response; Explosive blast; Transient response ID VIBRATION AB The foundation of the theory of functionally graded plates with simply supported edges, under a Fried-lander explosive air-blast are developed within the classical plate theory (CPT). Within the development of the theory, the two constituent phases, ceramic and metal, vary across the wall thickness according to a prescribed power law. The theory includes the geometrical non-linearities, the dynamic effects, compressive tensile edge loadings, the damping effects, and thermal effects. The static and dynamic solutions are developed leveraging the use of a stress potential with the Extended Galerkin method and the Runge-Kutta method. Validations with simpler cases within the specialized literature are shown. The analysis focuses on how to alleviate the unwanted effects of large deformations through proper material selection and the proper gradation of the constituent phases or materials. Published by Elsevier Ltd. C1 USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Hause, T (reprint author), USA, RDECOM TARDEC, Warren, MI 48397 USA. EM terry.hause@us.army.mil FU U.S. Army-RDECOM-TARDEC FX The author would like to express his thanks to the U.S. Army-RDECOM-TARDEC for their support and funding under the Independent Laboratory In-house Research program (ILIR). NR 9 TC 7 Z9 7 U1 2 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2011 VL 38 IS 5 BP 314 EP 321 DI 10.1016/j.ijimpeng.2010.11.006 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 767CU UT WOS:000290833700005 ER PT J AU Voros, S Rinehart, S Qian, Z Joshi, P Vazquez, G Fischer, C Belur, P Hulten, E Villines, TC AF Voros, Szilard Rinehart, Sarah Qian, Zhen Joshi, Parag Vazquez, Gustavo Fischer, Collin Belur, Pallavi Hulten, Edward Villines, Todd C. TI Coronary Atherosclerosis Imaging by Coronary CT Angiography Current Status, Correlation With Intravascular Interrogation and Meta-Analysis SO JACC-CARDIOVASCULAR IMAGING LA English DT Article DE atherosclerosis; coronary computed tomography angiography; intravascular ultrasound; meta-analysis; near-infrared spectroscopy; plaque imaging ID MULTIDETECTOR COMPUTED-TOMOGRAPHY; PROGNOSTIC VALUE; ARTERY-DISEASE; STABLE ANGINA; INTEROBSERVER VARIABILITY; NONINVASIVE ASSESSMENT; MORTALITY INCIDENCE; VIRTUAL HISTOLOGY; PLAQUE; ULTRASOUND C1 [Voros, Szilard; Rinehart, Sarah; Qian, Zhen; Joshi, Parag; Vazquez, Gustavo] Piedmont Heart Inst, Atlanta, GA 30309 USA. [Fischer, Collin; Belur, Pallavi; Hulten, Edward; Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Voros, S (reprint author), Piedmont Heart Inst, 1968 Peachtree Rd NW, Atlanta, GA 30309 USA. EM szilard.voros@piedmont.org OI Hulten, Edward/0000-0001-9281-0032; Villines, Todd/0000-0003-2674-3702 NR 39 TC 130 Z9 137 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-878X J9 JACC-CARDIOVASC IMAG JI JACC-Cardiovasc. Imag. PD MAY PY 2011 VL 4 IS 5 BP 537 EP 548 DI 10.1016/j.jcmg.2011.03.006 PG 12 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA 765MT UT WOS:000290712100014 PM 21565743 ER PT J AU Lang, J Bliese, PD Lang, JWB Adler, AB AF Lang, Jessica Bliese, Paul D. Lang, Jonas W. B. Adler, Amy B. TI Work Gets Unfair for the Depressed: Cross-Lagged Relations Between Organizational Justice Perceptions and Depressive Symptoms SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article DE organizational justice; depressive symptoms; cross-lagged panel design; occupational health; longitudinal ID MASLACH BURNOUT INVENTORY; OF-FIT INDEXES; MEASUREMENT INVARIANCE; RECIPROCAL RELATIONSHIPS; UNIPOLAR DEPRESSION; JOB-SATISFACTION; ROLE CLARITY; STRESS; SUPPORT; MODEL AB The organizational justice literature has consistently documented substantial correlations between organizational justice and employee depression. Existing theoretical literature suggests this relationship occurs because perceptions of organizational (in)justice lead to subsequent psychological health problems. Building on recent research on the affective nature of justice perceptions, in the present research we broaden this perspective by arguing there are also theoretical arguments for a reverse effect whereby psychological health problems influence perceptions of organizational justice. To contrast both theoretical perspectives, we test longitudinal lagged effects between organizational justice perceptions (i.e., distributive justice, interactional justice, interpersonal justice, informational justice, and procedural justice) and employee depressive symptoms using structural equation modeling. Analyses of 3 samples from different military contexts (N(1) = 625, N(2) = 134, N(3) = 550) revealed evidence of depressive symptoms leading to subsequent organizational justice perceptions. In contrast, the opposite effects of organizational justice perceptions on depressive symptoms were not significant for any of the justice dimensions. The findings have broad implications for theoretical perspectives on psychological health and organizational justice perceptions. C1 [Lang, Jessica; Bliese, Paul D.; Adler, Amy B.] US Army Med Res Unit Europe, Heidelberg, Germany. RP Lang, J (reprint author), Rhein Westfal TH Aachen, Inst Occupat Med, Pauwelsstr 30, D-52074 Aachen, Germany. EM jlang@ukaachen.de RI Lang, Jessica/I-2388-2014; OI Lang, Jessica/0000-0001-7802-8546; Lang, Jonas/0000-0003-1115-3443 NR 78 TC 40 Z9 40 U1 10 U2 54 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD MAY PY 2011 VL 96 IS 3 BP 602 EP 618 DI 10.1037/a0022463 PG 17 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 766IV UT WOS:000290776700011 PM 21299270 ER PT J AU Leavitt, K Fong, CT Greenwald, AG AF Leavitt, Keith Fong, Christina T. Greenwald, Anthony G. TI Asking about well-being gets you half an answer: Intra-individual processes of implicit and explicit job attitudes SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article DE implicit attitudes; automatic processes; well-being; job performance ID LEADER-MEMBER EXCHANGE; ORGANIZATIONAL CITIZENSHIP BEHAVIOR; ASSOCIATION TEST; INDIVIDUAL-DIFFERENCES; SOCIAL COGNITION; SELF-CONCEPT; SATISFACTION; METAANALYSIS; PERSONALITY; PERFORMANCE AB Job attitudes, as indicators of well-being, vary within individuals across cognitive processes and not just time. Research on employee well-being has relied primarily on self-reported measures of explicit job and life attitudes. Our work takes a different perspective on this issue by examining the role of implicit attitudes regarding one's organization, coworkers, and supervisor as indicators of well-being. Implicit attitudes are automatic, introspectively inaccessible, and predict behavior in socially sensitive contexts in which self-report measures may be impaired by impression management. The results of a field study demonstrate that implicit and explicit job attitudes reflect relatively independent intra-individual processes. Additionally, this study demonstrates that job performance and citizenship behaviors are best predicted by a combination of implicit and explicit job attitudes, and that a dissociation between implicit and explicit attitudes impacts organizational identification. We conclude with a discussion of how capturing implicit cognition in the workplace can better describe and subsequently help improve employee well-being. Copyright (C) 2011 John Wiley & Sons, Ltd. C1 [Leavitt, Keith] US Mil Acad, CAPE, West Point, NY 10996 USA. [Fong, Christina T.] Univ Washington, Foster Sch Business, Seattle, WA 98195 USA. [Greenwald, Anthony G.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. RP Leavitt, K (reprint author), US Mil Acad, CAPE, 621 Wilson Rd, West Point, NY 10996 USA. EM keith.leavitt@usma.edu; ctfong@uw.edu; agg@uw.edu RI Leavitt, Keith/D-6686-2012 OI Leavitt, Keith/0000-0003-3729-3997 NR 55 TC 19 Z9 20 U1 2 U2 44 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-3796 EI 1099-1379 J9 J ORGAN BEHAV JI J. Organ. Behav. PD MAY PY 2011 VL 32 IS 4 SI SI BP 672 EP 687 DI 10.1002/job.746 PG 16 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 764JJ UT WOS:000290625500009 ER PT J AU Lisiewski, AP Liu, HJ Yu, M Currano, L Gee, D AF Lisiewski, A. P. Liu, H. J. Yu, M. Currano, L. Gee, D. TI Fly-ear inspired micro-sensor for sound source localization in two dimensions SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ORMIA-OCHRACEA; DIRECTIONAL HEARING; SYSTEM AB Inspired by the hearing organ of the fly Ormia ochracea, a miniature sound localization sensor is developed, which can be used to pinpoint a sound source in two dimensions described by the azimuth and elevation angles. The sensor device employs an equilateral triangle configuration consisting of three mechanically coupled circular membranes whose oscillations are detected by a fiber-optic system. The experimental results indicate that significant amplification of the directional cues and directional sensitivity can be achieved with the fly-ear inspired sensor design. This work can provide a basis for the development of miniature sound localization sensors in two dimensions. (C) 2011 Acoustical Society of America C1 [Lisiewski, A. P.; Liu, H. J.; Yu, M.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Currano, L.; Gee, D.] USA, Res Lab, Adelphi, MD 20783 USA. RP Yu, M (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM alisiews@umd.edu; liuhj@umd.edu; mmyu@umd.edu; lcurrano@arl.army.mil; danny.gee@arl.army.mil RI Yu, Miao/M-6252-2013; Liu, Haijun/A-5060-2016 OI Yu, Miao/0000-0003-4180-5094; FU NSF [CMMI 0644914]; AFOSR [FA95500810042]; ONR DURIP; University of Maryland; DARPA through Army Research Laboratory (ARL), Adelphi, MD FX Support received from NSF under the Grant No. CMMI 0644914, AFOSR under the Grant No. FA95500810042, ONR DURIP, University of Maryland GRB award, and DARPA through Army Research Laboratory (ARL), Adelphi, MD, is gratefully acknowledged. NR 16 TC 6 Z9 6 U1 2 U2 14 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 2011 VL 129 IS 5 BP E166 EP E171 DI 10.1121/1.3565473 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 762CR UT WOS:000290450400002 PM 21568370 ER PT J AU Boyd, CM Leff, B Wolff, JL Yu, QL Zhou, J Rand, C Weiss, CO AF Boyd, Cynthia M. Leff, Bruce Wolff, Jennifer L. Yu, Qilu Zhou, Jing Rand, Cynthia Weiss, Carlos O. TI Informing Clinical Practice Guideline Development and Implementation: Prevalence of Coexisting Conditions Among Adults with Coronary Heart Disease SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE comorbidity; heart disease; guideline; prevalence ID QUALITY-OF-CARE; RANDOMIZED CONTROLLED-TRIALS; FREQUENT MENTAL DISTRESS; OLDER-ADULTS; UNITED-STATES; DIABETES-MELLITUS; AGING RESEARCH; CO-MORBIDITY; COMORBIDITY; FAILURE AB OBJECTIVES: To describe the prevalence of coexisting conditions that affect clinical decision-making in adults with coronary heart disease (CHD). DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey, 1999 to 2004. PARTICIPANTS: Eight thousand six hundred fifty-four people aged 45 and older; 1,259 with CHD. MEASUREMENTS: Coexisting conditions relevant to clinical decision-making and implementing therapy for CHD across three domains: chronic diseases, self-reported and laboratory-based clinical measures, and health status factors of self-reported and observed function. Prevalence was estimated according to sex and age, mutually exclusive patterns were examined, and the odds ratios (OR) of having incurred repeated hospitalization in the last year of participants with CHD and each complexity pattern versus CHD alone were modeled. RESULTS: The prevalence of comorbid chronic diseases in subjects with CHD was 56.7% for arthritis, 29.0% for congestive heart failure, 25.5% for chronic lower respiratory tract disease, 24.8% for diabetes mellitus, and 13.8% for stroke. Clinical factors adding to complexity of clinical decision-making for CHD were use of more than four medications (54.5%), urinary incontinence (48.6%), dizziness or falls (34.8%), low glomerular filtration rate (24.4%), anemia (10.1%), high alanine aminotransferase (5.9%), use of warfarin (10.2%), and health status factors were cognitive impairment (29.9%), mobility difficulty (40.4%), frequent mental distress (14.3%), visual impairment (16.7%), and hearing impairment (17.9%). Several comorbidity patterns were associated with high odds of hospitalization. CONCLUSION: Coexisting conditions that may modify the effectiveness of or interact with CHD therapies, influence the feasibility of CHD therapies, or alter patients' priorities concerning their health care should be considered in the development of trials and guidelines to better inform real-world clinical decision-making. J Am Geriatr Soc 59:797-805, 2011. C1 [Boyd, Cynthia M.; Leff, Bruce; Wolff, Jennifer L.; Yu, Qilu; Weiss, Carlos O.] Johns Hopkins Univ, Sch Med, Div Geriatr Med Gerontol, Baltimore, MD 21224 USA. [Rand, Cynthia] Johns Hopkins Univ, Sch Med, Div Pulm Med, Baltimore, MD 21224 USA. [Boyd, Cynthia M.; Leff, Bruce; Wolff, Jennifer L.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21224 USA. [Boyd, Cynthia M.; Leff, Bruce; Wolff, Jennifer L.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Roger C Lipitz Ctr Integrated Hlth Care, Baltimore, MD 21224 USA. [Boyd, Cynthia M.; Leff, Bruce; Wolff, Jennifer L.; Yu, Qilu; Weiss, Carlos O.] Johns Hopkins Med Inst, Ctr Aging & Hlth, Baltimore, MD 21205 USA. [Zhou, Jing] Walter Reed Army Med Ctr, United States Mil Canc Inst, Bethesda, MD USA. RP Boyd, CM (reprint author), Johns Hopkins Univ, Sch Med, Div Geriatr Med Gerontol, Mason Lord Bldg,Ctr Tower,7th Floor,5200 Eastern, Baltimore, MD 21224 USA. EM cboyd1@jhmi.edu FU federal government through the National Institute on Aging (NIA); Agency for Healthcare Research and Quality; National Heart, Lung and Blood Institute; National Institute for Mental Health (NIMH) [K01 MH082885-2]; Johns Hopkins Bayview Center for Innovative Medicine; Robert Wood Johnson Foundation Physician Faculty; Paul Beeson Career Development [NIA K23 AG032910] FX Drs. Boyd, Leff, Wolff, Rand, Weiss, and Yu and Ms. Zhou have been supported by the federal government through the National Institute on Aging (NIA); the Agency for Healthcare Research and Quality; the National Heart, Lung and Blood Institute; and the National Institute for Mental Health (NIMH). Drs. Boyd, Leff, Wolff, and Weiss have been supported by the non-profit Center for HealthCare Strategies for work on the prevalence of multimorbidity in the Medicaid population. Dr. Boyd is a Robert Wood Johnson Physician Faculty Scholar.; None of the authors received corporate financial support, consultantships, speaker arrangements, company holdings, or patents related to this research and the materials described in this article. For this work, Dr. Boyd was supported by the Johns Hopkins Bayview Center for Innovative Medicine, The Robert Wood Johnson Foundation Physician Faculty Scholars Program, and the Paul Beeson Career Development Award Program (NIA K23 AG032910, AFAR, The John A. Hartford Foundation, The Atlantic Philanthropies, The Starr Foundation, and an anonymous donor). Dr. Weiss was supported by the Robert Wood Johnson Foundation Amos Medical Faculty Development Program. Dr. Wolff was supported by NIMH K01 MH082885-2. NR 55 TC 30 Z9 30 U1 1 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD MAY PY 2011 VL 59 IS 5 BP 797 EP 805 DI 10.1111/j.1532-5415.2011.03391.x PG 9 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 763RZ UT WOS:000290578700003 PM 21568950 ER PT J AU Meitzler, TJ Reynolds, T Ebenstein, S Smith, G AF Meitzler, Thomas J. Reynolds, Thomas Ebenstein, Samuel Smith, Gregory TI Evaluating the Stability of a Metric for Determining the Health of Armor Plates SO MATERIALS EVALUATION LA English DT Article DE ceramic armor plates; nondestructive testing; piezoelectric transducers; damage detection AB A technique for evaluating the stability of a metric for determining the health of armor plates is presented. The metric is based on the following basic premise: the amplitudes and frequencies of the major vibrational modes of an undamaged armor plate constitute a basic signature of the armor plate. Damaging the armor plate should cause changes to both the amplitude and frequency of the significant vibrational modes. A metric has been developed to exploit these changes in order to distinguish between an undamaged and a damaged plate. C1 [Meitzler, Thomas J.; Reynolds, Thomas; Ebenstein, Samuel; Smith, Gregory] USA, RDECOM TARDEC, RDTA RS, Warren, MI 48397 USA. RP Meitzler, TJ (reprint author), USA, RDECOM TARDEC, RDTA RS, 6501 E 11 Mile Rd, Warren, MI 48397 USA. EM thomas.meitzler@us.army.mil RI Meitzler, Thomas/D-1065-2017 NR 3 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC NONDESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD MAY PY 2011 VL 69 IS 5 BP 597 EP 601 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA 764RR UT WOS:000290650700006 ER PT J AU Kamienski, M Tate, D Vega, CPTM AF Kamienski, Mary Tate, Denise Vega, C. P. T. Marielos TI The Silent Thief Diagnosis and Management of Osteoporosis SO ORTHOPAEDIC NURSING LA English DT Article ID INTRAVENOUS IBANDRONATE INJECTIONS; RANDOMIZED CONTROLLED-TRIAL; BISPHOSPHONATE-RELATED OSTEONECROSIS; VITAMIN-D SUPPLEMENTATION; BONE-MINERAL DENSITY; EVERY 3 MONTHS; POSTMENOPAUSAL WOMEN; HORMONE REPLACEMENT; VERTEBRAL FRACTURES; ATRIAL-FIBRILLATION AB Osteoporosis causes approximately 1.5 million fractures every year in the United States. Not only can these fractures be painful and disfiguring but they may reduce a person's ability to lead an active life as well. Osteoporosis affects every bone in the body, but the most common places where fractures occur are the back, hips, and wrists. Because osteoporosis thins bones, weakening them and making them more susceptible to fractures, practitioners must understand the risk factors and the diagnosis and management of this very common problem. This article, geared toward advanced practice nurses, presents a summary of the latest diagnostic tests and medication treatments available and approved by the Food and Drug Administration for the management of osteoporosis. C1 [Kamienski, Mary] UMDNJ Sch Nursing, Grad Program, Newark, NJ 07103 USA. [Kamienski, Mary] Univ Med & Dent New Jersey, Newark, NJ 07103 USA. [Vega, C. P. T. Marielos] USA, Nursing Corp, Brooke Army Med Ctr, San Antonio, TX USA. [Tate, Denise] UMDNJ Sch Nursing, Prelicensure Program, Newark, NJ USA. RP Kamienski, M (reprint author), UMDNJ Sch Nursing, Grad Program, Newark, NJ 07103 USA. NR 72 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0744-6020 J9 ORTHOP NURS JI Orthop. Nurs. PD MAY-JUN PY 2011 VL 30 IS 3 BP 162 EP 171 DI 10.1097/NOR.0b013e318219ab9d PG 10 WC Nursing; Orthopedics SC Nursing; Orthopedics GA 766MO UT WOS:000290787200003 PM 21597343 ER PT J AU Perkins, JG Shorr, AF Holcomb, JB AF Perkins, Jeremy G. Shorr, Andrew F. Holcomb, John B. TI The lost (to follow-up) intervention reply SO TRANSFUSION LA English DT Letter ID TRANSFUSED TRAUMA PATIENTS; PLATELET; IMPACT; TIME C1 [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Shorr, Andrew F.] Washington Hosp Ctr, Washington, DC 20010 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. RP Perkins, JG (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM jeremy.perkins1@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAY PY 2011 VL 51 IS 5 BP 1119 EP 1120 PG 3 WC Hematology SC Hematology GA 759SC UT WOS:000290267700030 ER PT J AU Sherali, HD Hill, JM McCrea, MV Trani, AA AF Sherali, Hanif D. Hill, Justin M. McCrea, Michael V. Trani, Antonio A. TI Integrating Slot Exchange, Safety, Capacity, and Equity Mechanisms Within an Airspace Flow Program SO TRANSPORTATION SCIENCE LA English DT Article DE airspace flow program; ground delay program; collaborative decision making; mediated bartering; slot exchanges; airline equity; air traffic management ID COLLABORATIVE DECISION-MAKING; GROUND DELAY PROGRAMS; MODEL AB In this paper, we study an airspace flow program in the context of weather-related disruptions by augmenting the airspace planning and collaborative decision-making model (APCDM). The proposed model selects among alternative flight plans for the affected flights while integrating slot exchange mechanisms induced by multiple ground delay programs (GDPs) to permit airlines to improve flight efficiencies through a mediated bartering of assigned slots, and simultaneously considering issues related to sector workloads and airspace conflicts, as well as overall equity concerns among the involved airlines in regard to accepted slot trades and flight plans. The APCDM is enhanced to include (a) the selection of slot exchange trade offers suggested by the airlines based on their allotted slots under a GDP; (b) connections between continuing flights; and (c) several alternative equity concepts. Both full and light versions of this model are developed and tested using realistic data derived from the enhanced traffic management system data provided by the Federal Aviation Administration. C1 [Sherali, Hanif D.] Virginia Polytech Inst & State Univ, Grado Dept Ind & Syst Engn, Blacksburg, VA 24061 USA. [Hill, Justin M.] USAF Studies & Anal Assessments & Lessons Learned, Washington, DC 20330 USA. [McCrea, Michael V.] USA, War Coll, Carlisle, PA 17013 USA. [Trani, Antonio A.] Virginia Polytech Inst & State Univ, Jr Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. RP Sherali, HD (reprint author), Virginia Polytech Inst & State Univ, Grado Dept Ind & Syst Engn, Blacksburg, VA 24061 USA. EM hanifs@vt.edu; justin.hill@us.af.mil; michael.mccrea@us.army.mil; vuela@vt.edu FU National Aeronautics and Space Administration (NASA) [NNA06CN21A, Z627302]; National Science Foundation [0552676]; Federal Aviation Administration grant FX This research has been supported by the National Aeronautics and Space Administration (NASA) under Grant NNA06CN21A (Subcontract Z627302), by the National Science Foundation under Grant 0552676, and by a Federal Aviation Administration grant under the National Center of Excellence for Aviation Operations Research program. Thanks are also due to Dr. Raymond Staats for his assistance in data acquisition and to two referees and an associate editor for their detailed constructive comments that have greatly helped improve the presentation of this paper. NR 15 TC 9 Z9 9 U1 0 U2 8 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 0041-1655 J9 TRANSPORT SCI JI Transp. Sci. PD MAY PY 2011 VL 45 IS 2 BP 271 EP 284 DI 10.1287/trsc.1100.0356 PG 14 WC Operations Research & Management Science; Transportation; Transportation Science & Technology SC Operations Research & Management Science; Transportation GA 764UB UT WOS:000290658100009 ER PT J AU Evans, MR Escalante, A Battafarano, DF Freeman, GL O'Leary, DH del Rincon, I AF Evans, Matthew R. Escalante, Agustin Battafarano, Daniel F. Freeman, Gregory L. O'Leary, Daniel H. del Rincon, Inmaculada TI Carotid Atherosclerosis Predicts Incident Acute Coronary Syndromes in Rheumatoid Arthritis SO ARTHRITIS AND RHEUMATISM LA English DT Article ID TUMOR-NECROSIS-FACTOR; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS; ENDOTHELIAL FUNCTION; FACTOR-ALPHA; MYOCARDIAL-INFARCTION; DISEASE-ACTIVITY; SYNOVIAL-FLUID; BODY-MASS; INFLAMMATION AB Objective. The role of atherosclerosis in the acute coronary syndromes (ACS) that occur in patients with rheumatoid arthritis (RA) has not been quantified in detail. We undertook this study to determine the extent to which ACS are associated with carotid atherosclerosis in RA. Methods. We prospectively ascertained ACS, defined as myocardial infarction, unstable angina, cardiac arrest, or death due to ischemic heart disease, in an RA cohort. We measured carotid atherosclerosis using high-resolution ultrasound. We used Cox proportional hazards models to estimate the association between ACS and atherosclerosis, adjusting for demographic features, cardiovascular (CV) risk factors, and RA manifestations. Results. We performed carotid ultrasound on 636 patients whom we followed up for 3,402 person-years. During this time, 84 patients experienced 121 new or recurrent ACS events, a rate of 3.5 ACS events per 100 patient-years (95% confidence interval [95% CI] 3.0-4.3). Among the 599 patients without a history of ACS, 66 incident ACS events occurred over 3,085 person-years, an incidence of 2.1 ACS events per 100 person-years (95% CI 1.7-2.7). The incidence of new ACS events per 100 patient-years was 1.1 (95% CI 0.6-1.7) among patients without plaque, 2.5 (95% CI 1.7-3.8) among patients with unilateral plaque, and 4.3 (95% CI 2.9-6.3) among patients with bilateral plaque. Covariates associated with incident ACS events independent of atherosclerosis included male sex, diabetes mellitus, and a cumulative glucocorticoid dose of >= 20 mu m. Conclusion. Atherosclerosis is strongly associated with ACS in RA. RA patients with carotid plaque, multiple CV risk factors (particularly diabetes mellitus or hypertension), many swollen joints, and a high cumulative dose of glucocorticoids, as well as RA patients who are men, are at high risk of ACS. C1 [Escalante, Agustin; Freeman, Gregory L.; del Rincon, Inmaculada] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Evans, Matthew R.; Battafarano, Daniel F.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [O'Leary, Daniel H.] Tufts Univ New England Med Ctr, Boston, MA 02111 USA. RP del Rincon, I (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM delrincon@uthscsa.edu FU NIH [K23-HL-004481, R01-HL-085742, R01-HD-037151, UL1-RR-025767]; Pfizer FX Supported by the NIH (grants K23-HL-004481, R01-HL-085742, R01-HD-037151, and UL1-RR-025767).; Dr. O'Leary has received consulting fees from Pfizer (less than $10,000) and holds stock or stock options in Medpace. NR 52 TC 91 Z9 94 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD MAY PY 2011 VL 63 IS 5 BP 1211 EP 1220 DI 10.1002/art.30265 PG 10 WC Rheumatology SC Rheumatology GA 764DY UT WOS:000290609800008 PM 21305526 ER PT J AU Kessler, R Sutcliffe, JB Bell, L Bradley, YC Anderson, S Banks, KP AF Kessler, Rebecca Sutcliffe, Joseph B. Bell, Lisa Bradley, Yong C. Anderson, Shane Banks, Kevin P. TI Negative Predictive Value of Breast-Specific Gamma Imaging in Low Suspicion Breast Lesions: A Potential Means for Reducing Benign Biopsies SO BREAST JOURNAL LA English DT Letter ID DATA SYSTEM; FOLLOW-UP; MAMMOGRAPHY; CANCER C1 [Kessler, Rebecca; Sutcliffe, Joseph B.; Bell, Lisa; Bradley, Yong C.; Anderson, Shane; Banks, Kevin P.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 10 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1075-122X J9 BREAST J JI Breast J. PD MAY-JUN PY 2011 VL 17 IS 3 BP 319 EP 321 DI 10.1111/j.1524-4741.2011.01077.x PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 759SN UT WOS:000290268800021 PM 21492299 ER PT J AU Felt, D Larson, S Griggs, C Nestler, C Wynter, M AF Felt, Deborah Larson, Steven Griggs, Chris Nestler, Catherine Wynter, Michelle TI Relationship of surface changes to metal leaching from tungsten composite shot exposed to three different soil types SO CHEMOSPHERE LA English DT Article DE Tungsten composite ammunition; Leaching potential; Scanning electron microscopy; Soil type; Soil lysimeter ID NICKEL; SORPTION; ALLOYS AB Physical changes that occur on the surface of fired shots due to firing and impact with soil may increase the dissolution of muniton metals. Increased metal dissolution could potentially increase metal transport and leaching, affecting metal concentrations in surface and groundwater. This research describes the relationship between the surface changes on fired tungsten-nickel-iron (94% W:2% Ni:4% Fe) composite shots and metals leaching from those shots. Tungsten composite shot was fired into, and aged in, three soil types (Silty Sand, Sandy Clay, and Silt) in mesoscale rainfall lysimeters to simulate live-fire conditions and subsequent interactions between the metals of the composite and soil. Leachate, runoff, and soil samples were collected from the lysimeters and analyzed for metal content. The shots were analyzed using scanning electron microscopy (SEM) to evaluate surface changes. SEM results indicated that a soil's particle size distribution initially affected the amount of metal that was sheared from the surface of the fired W-composite shots. Shearing was greatest in soils with larger soil particles (sand and gravel); shearing was least in soils composed of small soil particles (fines). Increased metallic shearing from the shot's surface was associated with increased W dissolution, compared to controls, following a simulated 1 year soil aging. Published by Elsevier Ltd. C1 [Felt, Deborah; Larson, Steven; Griggs, Chris; Wynter, Michelle] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nestler, Catherine] Appl Res Associates, Vicksburg, MS 39180 USA. RP Felt, D (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Deborah.Felt@usace.army.mil; Steven.I.Larson@usace.army.mil; Chris.S.Griggs@usace.army.mil; Chris.S.Griggs@usace.army.mil; Michelle.Wynter@usace.army.mil FU Army Environmental Policy Institute FX This work was funded by the Army Environmental Policy Institute. The sponsor did not assist with the actual research discussed in this article or the writing of this article. NR 22 TC 4 Z9 4 U1 3 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAY PY 2011 VL 83 IS 7 BP 955 EP 962 DI 10.1016/j.chemosphere.2011.02.035 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 762UU UT WOS:000290507800010 PM 21402395 ER PT J AU Ehrgott, JQ Rhett, RG Akers, SA Rickman, DD AF Ehrgott, J. Q., Jr. Rhett, R. G. Akers, S. A. Rickman, D. D. TI DESIGN AND FABRICATION OF AN IMPULSE MEASUREMENT DEVICE TO QUANTIFY THE BLAST ENVIRONMENT FROM A NEAR-SURFACE DETONATION IN SOIL SO EXPERIMENTAL TECHNIQUES LA English DT Article C1 [Ehrgott, J. Q., Jr.; Rhett, R. G.; Akers, S. A.; Rickman, D. D.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ehrgott, JQ (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 16 TC 5 Z9 5 U1 2 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0732-8818 J9 EXP TECHNIQUES JI Exp. Tech. PD MAY-JUN PY 2011 VL 35 IS 3 BP 51 EP 62 DI 10.1111/j.1747-1567.2009.00604.x PG 12 WC Engineering, Mechanical; Mechanics; Materials Science, Characterization & Testing SC Engineering; Mechanics; Materials Science GA 762OD UT WOS:000290488400009 ER PT J AU Huzar, TFM Oh, J Renz, EM Wolf, SE King, BT Chung, KK White, CE Malin, E Lundy, JB Kim, SH Blackbourne, LH Cancio, LC AF Huzar, Todd F. M. Oh, John Renz, Evan M. Wolf, Steven E. King, Booker T. Chung, Kevin K. White, Christopher E. Malin, Edward Lundy, Jonathan B. Kim, Seung H. Blackbourne, Lorne H. Cancio, Leopoldo C. TI Pneumatosis Intestinalis in Patients With Severe Thermal Injury SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID CYSTOIDES-INTESTINALIS; VENOUS GAS; PATHOGENESIS; MANAGEMENT; ETIOLOGY; ISCHEMIA; COLI; COMPLICATIONS; MORTALITY; BURNS AB Severe thermal injury is associated with pronounced changes in intestinal physiology, which may cause ischemia, infarction, and pneumatosis intestinalis (PI). PI is a pathologic condition defined as infiltration of gas into the gastrointestinal tract wall. Historically, PI prompted urgent surgery, yet some surgeons "watch and wait" to avoid the risks of a negative laparotomy. The authors reviewed experience with PI at a single burn center. They retrospectively identified burn center intensive care unit patients with radiographic or pathologic evidence of PI. Data included demographics, injury severity score, TBSA burned, operative findings, length of stay, and mortality. From January 2003 through August 2009, 1129 patients were admitted to the authors' burn center intensive care unit. Fifteen had PI. Twelve had radiographic evidence of PI, and 10 had PI associated with intestinal infarction. Nonsurvivors had lower base deficits (P = .02), higher lactate levels (P = .05), and required vasopressor support (P = .02) within 24 hours of developing PI. Massive intestinal infarction (P = .004) and open abdomens (P = .004) were more common among nonsurvivors. PI can be identified by radiologic or pathologic findings. The authors' experience with PI among patients with burn injury revealed a high mortality rate. Because of the association of bowel ischemia with PI, exploratory laparotomy should be strongly considered in patients with burn injury with radiographic evidence of PI. (J Burn Care Res 2011; 32:e37-e44) C1 [Huzar, Todd F. M.; Oh, John; Renz, Evan M.; Wolf, Steven E.; King, Booker T.; Chung, Kevin K.; White, Christopher E.; Malin, Edward; Lundy, Jonathan B.; Kim, Seung H.; Blackbourne, Lorne H.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 35 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2011 VL 32 IS 3 BP E37 EP E44 DI 10.1097/BCR.0b013e318217f8f6 PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 760EZ UT WOS:000290308500001 PM 21422942 ER PT J AU Houston, JR Dean, RG AF Houston, J. R. Dean, R. G. TI Sea-Level Acceleration Based on US Tide Gauges and Extensions of Previous Global-Gauge Analyses SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Global climate change; Sea level rise ID WATER STORAGE; RISE AB HOUSTON, J.R. and DEAN, R.G., 2011. Sea-level acceleration based on U.S. tide gauges and extensions of previous global-gauge analyses. Journal of Coastal Research, 27(3), 409-417. West Palm Beach (Florida), ISSN 0749-0208. Without sea-level acceleration, the 20th-century sea-level trend of 1.7 mm/y would produce a rise of only approximately 0.15 m from 2010 to 2100; therefore, sea-level acceleration is a critical component of projected sea-level rise. To determine this acceleration, we analyze monthly-averaged records for 57 U.S. tide gauges in the Permanent Service for Mean Sea Level (PSMSL) data base that have lengths of 60-156 years. Least-squares quadratic analysis of each of the 57 records are performed to quantify accelerations, and 25 gauge records having data spanning from 1930 to 2010 are analyzed. In both cases we obtain small average sea-level decelerations. To compare these results with worldwide data, we extend the analysis of Douglas (1992) by an additional 25 years and analyze revised data of Church and White (2006) from 1930 to 2007 and also obtain small sea-level decelerations similar to those we obtain from U.S. gauge records. C1 [Houston, J. R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, R. G.] Univ Florida, Dept Civil & Coastal Civil Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil; dean@coastal.ufl.edu NR 33 TC 74 Z9 77 U1 2 U2 19 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD MAY PY 2011 VL 27 IS 3 BP 409 EP 417 DI 10.2112/JCOASTRES-D-10-00157.1 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 764PY UT WOS:000290645600001 ER PT J AU Larsen, RJ Ting, FCK Jones, AL AF Larsen, Ryan J. Ting, Francis C. K. Jones, Allen L. TI Flow Velocity and Pier Scour Prediction in a Compound Channel: Big Sioux River Bridge at Flandreau, South Dakota SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article DE Compound channel; Two-dimensional flow modeling; Bridge hydraulics; Pier scour; Cohesive soils ID SRICOS; SOILS AB The two-dimensional (2D) depth-averaged river model Finite-Element Surface-Water Modeling System (FESWMS) was used to predict flow distribution at the bend of a compound channel. The site studied was the Highway 13 bridge over the Big Sioux River in Flandreau, South Dakota. The Flandreau site has complex channel and floodplain geometry that produces unique flow conditions at the bridge crossing. The 2D model was calibrated using flow measurements obtained during two floods in 1993. The calibrated model was used to examine the hydraulic and geomorphic factors that affect the main channel and floodplain flows and the flow interactions between the two portions. A one-dimensional (1D) flow model of the bridge site was also created in Hydrologic Engineering Centers River Analysis System (HEC-RAS) for comparison. Soil samples were collected from the bridge site and tested in an erosion function apparatus (EFA) to determine the critical shear stress and erosion rate constant. The results of EFA testing and 2D flow modeling were used as inputs to the Scour Rate in Cohesive Soils (SRICOS) method to predict local scour at the northern and southernmost piers. The sensitivity of predicted scour depth to the hydraulic and soil parameters was examined. The predicted scour depth was very sensitive to the approach-flow velocity and critical shear stress. Overall, this study has provided a better understanding of 2D flow effects in compound channels and an overall assessment of the SRICOS method for prediction of bridge pier scour. DOI: 10.1061/(ASCE)HY.1943-7900.0000334. (C) 2011 American Society of Civil Engineers. C1 [Ting, Francis C. K.; Jones, Allen L.] S Dakota State Univ, Dept Civil & Environm Engn, Brookings, SD 57007 USA. [Larsen, Ryan J.] US Army Corps Engineers, Omaha, NE 68102 USA. RP Ting, FCK (reprint author), S Dakota State Univ, Dept Civil & Environm Engn, Brookings, SD 57007 USA. EM francis.ting@sdstate.edu FU South Dakota Department of Transportation (SDDOT); United States Department of Transportation; MPC FX Funding for this study was provided by the South Dakota Department of Transportation (SDDOT) and United States Department of Transportation to the Mountain-Plains Consortium (MPC). The support of SDDOT and MPC is gratefully acknowledged. Ryan Thompson and Richard Liggett from the USGS conducted the topographic and bathymetric survey; their assistance is greatly appreciated. We would also like to thank Derrick Dasenbrock at the Minnesota Department of Transportation (MNDOT) for assisting us with EFA testing. NR 16 TC 5 Z9 5 U1 1 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAY PY 2011 VL 137 IS 5 BP 595 EP 605 DI 10.1061/(ASCE)HY.1943-7900.0000334 PG 11 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 762DT UT WOS:000290453200010 ER PT J AU Dave, J Chen, ZY Liao, ZL Cartagena, C Yao, CP Lu, XCM Tortella, F AF Dave, Jitendra Chen, Zhiyong Liao, Zhilin Cartagena, Cassandra Yao, Changping Lu, X. -C. May Tortella, Frank TI NEUROPROTECTIVE EFFICACY OF NEFIRACETAM IN IN VITRO MODELS OF NEUROTOXICITY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 10th International Neurotrauma Symposium (INTS) CY APR 27-30, 2011 CL Shanghai, PEOPLES R CHINA C1 [Dave, Jitendra; Chen, Zhiyong; Liao, Zhilin; Cartagena, Cassandra; Yao, Changping; Lu, X. -C. May; Tortella, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY PY 2011 VL 28 IS 5 BP A71 EP A71 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 762JI UT WOS:000290472100219 ER PT J AU Mondello, S Gabrielli, A Catani, S D'Ippolito, M Tortella, F Schmidt, K Hayes, RL Wang, KK Formisano, R AF Mondello, Stefania Gabrielli, Andrea Catani, Sheila D'Ippolito, Mariagrazia Tortella, Frank Schmidt, Kara Hayes, Ronald L. Wang, Kevin K. Formisano, Rita TI ROLE OF SERUM BIOMARKERS IN INDIVIDUALS IN COMA OR VEGETATIVE STATE AFTER TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 10th International Neurotrauma Symposium (INTS) CY APR 27-30, 2011 CL Shanghai, PEOPLES R CHINA C1 Banyan Biomarkers Inc, Alachua, FL USA. Univ Florida, Gainesville, FL 32611 USA. Santa Lucia Fdn, Rome, Italy. Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY PY 2011 VL 28 IS 5 BP A8 EP A8 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 762JI UT WOS:000290472100022 ER PT J AU Shear, D Pederson, R Rosen, E Sun, J Lu, XCM Tortella, FC AF Shear, Deborah Pederson, Rebecca Rosen, Elliot Sun, Justin Lu, Xi-Chun May Tortella, Frank C. TI NEUROPROTECTIVE EFFECTS OF PROGESTERONE AND DEXTROMETHORPHAN IN A RODENT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 10th International Neurotrauma Symposium (INTS) CY APR 27-30, 2011 CL Shanghai, PEOPLES R CHINA C1 [Shear, Deborah; Pederson, Rebecca; Rosen, Elliot; Sun, Justin; Lu, Xi-Chun May; Tortella, Frank C.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY PY 2011 VL 28 IS 5 BP A30 EP A31 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 762JI UT WOS:000290472100090 ER PT J AU Walters, TJ Mase, VJ Roe, JL Dubick, MA Christy, RJ AF Walters, Thomas J. Mase, Vincent J., Jr. Roe, Janet L. Dubick, Michael A. Christy, Robert J. TI Poloxamer-188 Reduces Muscular Edema After Tourniquet-Induced Ischemia-Reperfusion Injury in Rats SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Muscle injury; Edema; Triblock copolymer; Compartment syndrome; Microvascular ID SKELETAL-MUSCLE ISCHEMIA; MAJOR LIMB TRAUMA; COMPARTMENT SYNDROME; SURFACTANT POLOXAMER-188; TISSUE-INJURY; IN-VIVO; PATHOPHYSIOLOGY; RESUSCITATION; MEMBRANES; RECOVERY AB Background: Skeletal muscle injury can result in significant edema, which can in turn lead to the development of acute extremity compartment syndrome (CS). Poloxamer-188 (P-188), a multiblock copolymer surfactant, has been shown to decrease edema by sealing damaged membranes in a number of tissues after a variety of injury modalities. The objective is to determine whether the administration of P-188 significantly reduces skeletal muscle edema associated with ischemia/reperfusion injury (I-R). Methods: Male Sprague-Dawley rats underwent 180 minutes of tourniquet-induced ischemia. Five minutes before tourniquet release, rats received either a bolus of (1) P-188 (150 mg/kg; P-188 group) or (2) vehicle (Vehicle group) via a jugular catheter (n = 10 per group). After 240 minutes reperfusion, both groups received a second bolus of either P-188 (P-188) or vehicle (Vehicle) via a tail vein catheter. Sixteen hours later, rats were killed; muscle weights were determined, infarct size (2,3,5-triphenyltetrazolium chloride method), and blinded histologic analysis (hematoxylin and eosin) were performed on the gastrocnemius and tibialis anterior muscles, as well as indices of antioxidant status. Results: P-188 resulted in significantly less edema (wet weight) and reduced an index of lipid peroxidation compared with Vehicle (p < 0.05). Wet: dry weight ratios were less in the P-188 group (indicating less edema). Muscle viability as indicated by 2,3,5-triphenyltetrazolium chloride staining or routine histology did not reveal statistically significant differences between groups. Conclusion: P-188 significantly reduced ischemia-reperfusion-related muscle edema and lipid peroxidation but did not impact muscle viability. Excess edema can lead to acute extremity CS, which is associated with significant morbidity and mortality. P-188 may provide a potential adjunctive treatment for the reduction of CS. C1 [Walters, Thomas J.; Mase, Vincent J., Jr.; Roe, Janet L.; Christy, Robert J.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, San Antonio, TX 78234 USA. [Dubick, Michael A.] USA, Inst Surg Res, Hemostasis Res Proigram, San Antonio, TX 78234 USA. RP Walters, TJ (reprint author), USA, Inst Surg Res, Regenerat Med Res Program, San Antonio, TX 78234 USA. EM thomas.walters@amedd.army.mil FU United States Army Medical Research and Materiel Command FX Supported by the United States Army Medical Research and Materiel Command. NR 40 TC 11 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 BP 1192 EP 1197 DI 10.1097/TA.0b013e318217879a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762LQ UT WOS:000290480300043 PM 21610433 ER PT J AU Chung, KK AF Chung, Kevin K. TI Crush Syndrome and Acute Kidney Injury in the Wenchuan Earthquake EDITORIAL COMMENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 BP 1217 EP 1218 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762LQ UT WOS:000290480300048 ER PT J AU Rasmussen, TE Woodson, J Rich, NM Mattox, KL AF Rasmussen, Todd E. Woodson, Jonathan Rich, Norman M. Mattox, Kenneth L. TI Vascular Trauma at a Crossroads SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Operational crisis; Medical manpower shortage; Vascular injury; Surgical training; Wartime injury; Trauma; Trauma endovascular techniques ID OPERATION-ENDURING-FREEDOM; IRAQI-FREEDOM; GLOBAL WAR; INJURY; MANAGEMENT; SURVIVAL; SURGERY; WARTIME; DEATH C1 [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.; Woodson, Jonathan; Rich, Norman M.; Mattox, Kenneth L.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Woodson, Jonathan] Boston Univ, Sch Med, Sect Vasc & Endovasc Surg, Boston, MA 02118 USA. [Mattox, Kenneth L.] Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Suite B, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil NR 17 TC 8 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 BP 1291 EP 1293 DI 10.1097/TA.0b013e3182178994 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762LQ UT WOS:000290480300064 PM 21610443 ER PT J AU Blackbourne, LH Rasmussen, TE AF Blackbourne, Lorne H. Rasmussen, Todd E. TI Foreword-Combat Prehospital Resuscitation SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID DEATH C1 [Blackbourne, Lorne H.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 2 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 SU S BP S1 EP S1 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762RU UT WOS:000290499200001 PM 21841557 ER PT J AU Cap, AP Perkins, JG AF Cap, Andrew P. Perkins, Jeremy G. TI Lyophilized Platelets: Challenges and Opportunities SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT US Army-Institute-of-Surgical-Research Prehospital Fluid Conference CY JAN 08-09, 2010 CL Ft Worth, TX SP US Army Inst Surg Res & Casual Care Res, US Army Med Res Mat Command ID BLEEDING-TIME; FRESH; PRESERVATION; HEMORRHAGE C1 [Cap, Andrew P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cap, AP (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM andre.p.cap@us.army.mil NR 15 TC 8 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 SU S BP S59 EP S60 DI 10.1097/TA.0b013e31821a606d PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762RU UT WOS:000290499200022 PM 21841577 ER PT J AU McSwain, NE Champion, HR Fabian, TC Hoyt, DB Wade, CE Eastridge, BJ Rasmussen, TE Roussel, RR Butler, FK Holcomb, JB Schreiber, MA Shackford, SR Blackbourne, LH AF McSwain, Norman E. Champion, Howard R. Fabian, Timothy C. Hoyt, David B. Wade, Charles E. Eastridge, Brian J. Rasmussen, Todd E. Roussel, Robert R. Butler, Frank K. Holcomb, John B. Schreiber, Martin A. Shackford, Steven R. Blackbourne, Lorne H. TI State of the Art of Fluid Resuscitation 2010: Prehospital and Immediate Transition to the Hospital SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID DAMAGE CONTROL RESUSCITATION; COMBAT CASUALTY CARE; HYDROXYETHYL STARCH; SPECIAL OPERATIONS; TRAUMA PATIENTS; BLOOD; COAGULOPATHY; SURVIVAL; INJURY; MORTALITY C1 [McSwain, Norman E.; Champion, Howard R.; Fabian, Timothy C.; Hoyt, David B.; Wade, Charles E.; Eastridge, Brian J.; Rasmussen, Todd E.; Roussel, Robert R.; Butler, Frank K.; Holcomb, John B.; Schreiber, Martin A.; Shackford, Steven R.; Blackbourne, Lorne H.] USA, Inst Surg Res, Dept Army, Ft Sam Houston, TX 78234 USA. RP McSwain, NE (reprint author), Tulane Univ, Sch Med, Dept Surg, 1430 Tulane Ave,SL-22, New Orleans, LA 70112 USA. EM nmcswai@tulane.edu NR 57 TC 37 Z9 38 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 SU S BP S2 EP S10 DI 10.1097/TA.0b013e31821b201d PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762RU UT WOS:000290499200002 PM 21841563 ER PT J AU Rentas, FJ AF Rentas, Francisco J. TI Cryopreserved Red Blood Cells: Summary SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT US Army-Institute-of-Surgical-Research Prehospital Fluid Conference CY JAN 08-09, 2010 CL Ft Worth, TX SP USArmy Inst Surg Res & Casual Care Res, US Army Med Res Mat Command ID WT/VOL GLYCEROL; IN-VITRO; FROZEN; 4-DEGREES-C; AS-3; DEGLYCEROLIZATION; ACP-215 C1 USA, Serv Blood Program Off, Falls Church, VA 22041 USA. RP Rentas, FJ (reprint author), USA, Serv Blood Program Off, 5109 Leesburg Pike,Suite 698, Falls Church, VA 22041 USA. EM francisco.rentas@amedd.army.mil NR 8 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 SU S BP S45 EP S46 DI 10.1097/TA.0b013e31821a5a61 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762RU UT WOS:000290499200017 PM 21841572 ER PT J AU Wehrum, MJ Buhimschi, IA Salafia, C Thung, S Bahtiyar, MO Werner, EF Campbell, KH Laky, C Sfakianaki, AK Zhao, GM Funai, EF Buhimschi, CS AF Wehrum, Mark J. Buhimschi, Irina A. Salafia, Carolyn Thung, Stephen Bahtiyar, Mert O. Werner, Erica F. Campbell, Katherine H. Laky, Christine Sfakianaki, Anna K. Zhao, Guomao Funai, Edmund F. Buhimschi, Catalin S. TI Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE angiogenesis; invasion; myometrium; trophoblast; vascular endothelial growth factor ID ANGIOGENIC FACTORS; EXTRAVILLOUS TROPHOBLAST; SEVERE PREECLAMPSIA; SOLUBLE FLT-1; EXPRESSION; RECEPTORS; WOMEN; CANCER; CELLS; VEGF AB OBJECTIVE: We sought to characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta, or percreta shares features of epithelial-to-mesenchymal transition. STUDY DESIGN: We analyzed gestational age-matched serum samples from 90 pregnant women with either complete placenta previa (n = 45) or uncomplicated pregnancies (n = 45). Vascular endothelial growth factor (VEGF), placental growth factor, and soluble form of fms-like-tyrosine-kinase-1 were immunoassayed. VEGF and phosphotyrosine immunoreactivity was surveyed in histological specimens relative to expression of vimentin and cytokeratin-7. RESULTS: Women with previa and invasive placentation (accreta, n = 5; increta, n = 6; percreta, n = 2) had lower systemic VEGF (invasive previa: median 0.8 [0.02-3.4] vs control 6.5 [2.7-10.5] pg/mL, P = .02). VEGF and phosphotyrosine immunostaining predominated in the invasive extravillous trophoblasts that coexpressed vimentin and cytokeratin-7, an epithelial-to-mesenchymal transition feature and tumorlike cell phenotype. CONCLUSION: Lower systemic free VEGF and a switch of the interstitial extravillous trophoblasts to a metastable cell phenotype characterize placenta previa with excessive myometrial invasion. C1 [Wehrum, Mark J.; Buhimschi, Irina A.; Thung, Stephen; Bahtiyar, Mert O.; Werner, Erica F.; Campbell, Katherine H.; Laky, Christine; Sfakianaki, Anna K.; Zhao, Guomao; Funai, Edmund F.; Buhimschi, Catalin S.] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA. [Salafia, Carolyn] Placental Analyt LLC, Larchmont, NY USA. RP Wehrum, MJ (reprint author), Womack Army Med Ctr, Dept Obstet Gynecol, WAMC Stop A,2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM mark.j.wehrum@us.army.mil RI Bahtiyar, Mert/M-8265-2015 OI Bahtiyar, Mert/0000-0002-5813-8067 FU National Institutes of Health [R01 HD 047321, RO3 HD 50249]; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine; Yale Women's Reproductive Health Research Career Development Center [K12 HD 1027766] FX This work was supported by National Institutes of Health Grant no. R01 HD 047321 (I.A.B.) and the Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine. C.S.B. was supported by the Yale Women's Reproductive Health Research Career Development Center (K12 HD 1027766) and NIH RO3 HD 50249. NR 49 TC 2 Z9 3 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD MAY PY 2011 VL 204 IS 5 AR 411.e1 DI 10.1016/j.ajog.2010.12.027 PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 758YZ UT WOS:000290206200027 PM 21316642 ER PT J AU Waterman, BR Belmont, PJ Cameron, KL Svoboda, SJ Alitz, CJ Owens, BD AF Waterman, Brian R. Belmont, Philip J., Jr. Cameron, Kenneth L. Svoboda, Steven J. Alitz, Curtis J. Owens, Brett D. TI Risk Factors for Syndesmotic and Medial Ankle Sprain Role of Sex, Sport, and Level of Competition SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE ankle; sprain; medial; syndesmosis; deltoid; athlete; high ankle ID FEMALE ARMY TRAINEES; FOOTBALL PLAYERS; INJURIES; EPIDEMIOLOGY; SOCCER; HOCKEY; GENDER; RATES AB Background: Syndesmotic and medial ankle sprains constitute up to 15% of all ankle sprains in athletic populations and can result in significant time lost to injury and long-term disability. Purpose: The objective of this study was to estimate the rate of syndesmotic and medial ankle sprain injuries and identify risk factors associated with these injuries within the physically active cadet population at the United States Military Academy (USMA). Study Design: Cohort study; Level of evidence, 2. Methods: The Cadet Illness and Injury Tracking System (CIITS) database at USMA was queried for all ankle injuries between 2005 and 2009. Sex, level of competition, and exposure to sport were among risk factors analyzed. Results: Among 20 336 person-years, 1206 cadets sustained ankle sprain. Syndesmotic (6.7%) and medial (5.1%) ankle sprains had an incidence rate (IR) of 4.8 and 3.5 per 1000 person-years, respectively. Compared with women, men were 3 times more likely to experience medial ankle sprain (IR ratio [IRR] 3.37; 95% confidence interval [CI]: 1.05, 10.74], but there was no difference in rate of syndesmotic sprains by sex (IRR 1.06; 95% CI: 0.58, 1.95). Athletics accounted for 81% of syndesmotic sprains and 64% of medial sprains. Sprint football (52.3), team handball (men's, 34.7), soccer (men's, 30.5; women's, 6.5), and basketball (men's, 24.8; women's, 6.7) had the highest syndesmotic IR per 100 000 athlete-exposures. Medial sprain IR was highest in men's rugby (16.6) and gymnastics (14.0). When analyzed by athlete-exposure, male intercollegiate athletes had a greater risk of syndesmotic sprain than their female counterparts (3.53; 95% CI: 1.26, 9.83). Furthermore, intercollegiate level of competition had an increased risk of syndesmotic sprain when compared with intramural level (IRR 2.41; 95% CI: 1.03, 5.65). Conclusion: Male athletes have an over threefold greater risk of medial ankle sprain. Male sex and higher level of competition are risk factors for syndesmotic ankle sprain during athletics. C1 [Owens, Brett D.] Keller Army Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Belmont, Philip/0000-0003-2618-199X; Cameron, Kenneth/0000-0002-6276-4482 NR 34 TC 30 Z9 32 U1 2 U2 24 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY PY 2011 VL 39 IS 5 BP 992 EP 998 DI 10.1177/0363546510391462 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 759NC UT WOS:000290252200015 PM 21289274 ER PT J AU Moon, JE Deye, GA Miller, L Fracisco, S Miller, RS Tosh, D Cummings, JF Ohrt, C Magill, AJ AF Moon, James E. Deye, Gregory A. Miller, Lori Fracisco, Susan Miller, R. Scott Tosh, Donna Cummings, James F. Ohrt, Colin Magill, Alan J. TI Plasmodium falciparum Infection during Suppressive Prophylaxis with Mefloquine Does Not Induce an Antibody Response to Merozoite Surface Protein-1(42) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA; TERM AB A sensitive biomarker of malaria infection would obviate the need for placebo control arms in clinical trials of malaria prophylactic drugs. Antibodies to the 42-kDa fragment of merozoite surface protein-1 (MSP1(42)) have been identified as a potential marker of malaria exposure in individuals receiving prophylaxis with mefloquine. We conducted an open-label trial to determine the sensitivity of seroconversion to MSP1(42), defined as a fourfold rise in enzyme-linked immunosorbant assay (ELISA) titer, among 23 malaria nave volunteers receiving mefloquine prophylaxis and 6 controls after Plasmodium falciparum sporozoite challenge. All members of the control cohort but none of the mefloquine cohort developed patent parasitemia. Four of six controls but zero of the mefloquine cohort seroconverted to MSP1(42). We conclude that malaria infection during suppressive prophylaxis does not induce antibody response to the blood-stage antigen MSP1(42) in a malaria-nave study population. C1 [Moon, James E.; Deye, Gregory A.; Miller, Lori; Fracisco, Susan; Miller, R. Scott; Tosh, Donna; Cummings, James F.; Ohrt, Colin; Magill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Moon, JE (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM james.e.moon@us.army.mil; gregory.deye@us.army.mil; robert.s.miller@us.army.mil; susan.fracisco@us.army.mil; robert.s.miller@us.army.mil; donna.tosh@amedd.army.mil; james.cummings@us.army.mil; colin.ohrt@amedd.army.mil; alan.magill@us.army.mil RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 FU United States Army Medical Materiel Development Activity FX This project was supported by the United States Army Medical Materiel Development Activity. NR 13 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2011 VL 84 IS 5 BP 825 EP 829 DI 10.4269/ajtmh.2011.10-0699 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 760ZW UT WOS:000290365100028 PM 21540397 ER PT J AU Cuda, SP Musser, JE Belnap, CM Thibault, GP AF Cuda, Scott P. Musser, John E. Belnap, Christina M. Thibault, Gregory P. TI Incidence and clinical significance of arterial injury in varicocele repair SO BJU INTERNATIONAL LA English DT Article DE varicocele; ligation; atrophy; complications ID LIGATION; OUTCOMES AB OBJECTIVE This study was performed to histologically determine the rate of arterial injury in varicocele ligation surgery and to determine the clinical significance of these arterial injuries. MATERIALS AND METHODS 41 men who underwent varicocele ligation surgery, and had segments of each ligated vessel examined histologically. The patients were followed prospectively to determine the effect of arterial injury on surgical results and clinical complications. RESULTS Arterial ligation was identified in 6 of 41 patients (12%), and in 7 of 132 specimens (5%), which is higher than previous reports. Arterial injury was not associated with testicular atrophy and there was no apparent effect of arterial injury on surgical outcome. CONCLUSION The rate of arterial injury during varicocele repair is higher than previously reported, but the clinical significance of these injuries appears to be limited. C1 [Musser, John E.] Tripler Army Med Ctr, Urol Sect, MCHK DSG, Honolulu, HI 96859 USA. [Belnap, Christina M.] Univ Hawaii, John A Burns Sch Med, Dept Pathol, Honolulu, HI 96822 USA. RP Musser, JE (reprint author), Tripler Army Med Ctr, Urol Sect, MCHK DSG, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.e.musser@us.army.mil NR 6 TC 5 Z9 7 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1464-4096 J9 BJU INT JI BJU Int. PD MAY PY 2011 VL 107 IS 10 BP 1635 EP 1637 DI 10.1111/j.1464-410X.2010.09643.x PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 755AN UT WOS:000289899100017 PM 20950303 ER PT J AU Dupuy, LC Richards, MJ Ellefsen, B Chau, L Luxembourg, A Hannaman, D Livingston, BD Schmaljohn, CS AF Dupuy, Lesley C. Richards, Michelle J. Ellefsen, Barry Chau, Lillian Luxembourg, Alain Hannaman, Drew Livingston, Brian D. Schmaljohn, Connie S. TI A DNA Vaccine for Venezuelan Equine Encephalitis Virus Delivered by Intramuscular Electroporation Elicits High Levels of Neutralizing Antibodies in Multiple Animal Models and Provides Protective Immunity to Mice and Nonhuman Primates SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID AIRBORNE CHALLENGE; AEROSOL CHALLENGE; ENCEPHALOMYELITIS VIRUS; ATTENUATED VACCINES; CAPSID PROTEIN; IMMUNOGENICITY; INFECTION; LIVE; EXPRESSION; CELLS AB We evaluated the immunogenicity and protective efficacy of a DNA vaccine expressing codon-optimized envelope glycoprotein genes of Venezuelan equine encephalitis virus (VEEV) when delivered by intramuscular electroporation. Mice vaccinated with the DNA vaccine developed robust VEEV-neutralizing antibody responses that were comparable to those observed after administration of the live-attenuated VEEV vaccine TC-83 and were completely protected from a lethal aerosol VEEV challenge. The DNA vaccine also elicited strong neutralizing antibody responses in rabbits that persisted at high levels for at least 6 months and could be boosted by a single additional electroporation administration of the DNA performed approximately 6 months after the initial vaccinations. Cynomolgus macaques that received the vaccine by intramuscular electroporation developed substantial neutralizing antibody responses and after an aerosol challenge had no detectable serum viremia and had reduced febrile reactions, lymphopenia, and clinical signs of disease compared to those of negative-control macaques. Taken together, our results demonstrate that this DNA vaccine provides a potent means of protecting against VEEV infections and represents an attractive candidate for further development. C1 [Dupuy, Lesley C.; Richards, Michelle J.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Ellefsen, Barry; Chau, Lillian; Luxembourg, Alain; Hannaman, Drew; Livingston, Brian D.] Ichor Med Syst Inc, San Diego, CA 92121 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. EM connie.schmaljohn@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [H.H.0001_07_RD_B, HDTRA1-07-C-0029] FX This research was supported by grant H.H.0001_07_RD_B to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and contract HDTRA1-07-C-0029 to Ichor Medical Systems, Inc., from the Defense Threat Reduction Agency (DTRA). This research was performed under U.S. Army Medical Research and Material Command (USAMRMC) Cooperative Research and Development Agreement (CRADA) W81XWH-07-0029 between USAMRIID and Ichor Medical Systems, Inc. NR 52 TC 24 Z9 24 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2011 VL 18 IS 5 BP 707 EP 716 DI 10.1128/CVI.00030-11 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 758IB UT WOS:000290156600002 PM 21450977 ER PT J AU Hurst, FP Lee, JJ Jindal, RM Agodoa, LY Abbott, KC AF Hurst, Frank P. Lee, Jessica J. Jindal, Rahul M. Agodoa, Lawrence Y. Abbott, Kevin C. TI Outcomes Associated with Influenza Vaccination in the First Year after Kidney Transplantation SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ANTIBODY-RESPONSE; RECIPIENTS; DISEASE; REJECTION; MORTALITY; THERAPY; SAFE AB Background and objectives Influenza vaccination is recommended in all renal transplant recipients. However, immunosuppression in the early period post-transplant may attenuate the immunologic response to the vaccine. Additionally, it has been theorized that vaccination can induce an immune response that could trigger rejection episodes. Design, setting, participants, & measurements In a retrospective cohort of 51,730 adult Medicare primary patients who were first transplanted from January 2000 to July 2006 and followed through October 2006, we assessed Medicare claims for influenza vaccination and influenza infections, respectively. Outcomes included allograft loss and death. Results There were 9678 (18.7%) patients with claims for influenza vaccination in the first year post-transplant. Factors associated with vaccination included older age, diabetes, later year of transplant, and tacrolimus or mycophenolate at discharge. Vaccinations were less frequent among men, African Americans, highly sensitized patients, or those receiving induction immunosuppression or expanded criteria donor kidneys. Vaccination in the first year after transplant was associated with lower risk of subsequent allograft loss and death. Claims for influenza infection were reported in 310 (0.6%) patients and were not significantly associated with graft loss, although there was a trend toward death. Conclusions In the first year after renal transplantation, influenza vaccination was associated with a lower risk of subsequent allograft loss and death. Although this study cannot comment on formation of protective antibodies after vaccination, these data do not support withholding vaccination on the basis of concerns of adversely affecting allograft function. Clin J Ant Soc Nephrol 6: 1192-1197, 2011. doi: 10.2215/CJN.05430610 C1 [Hurst, Frank P.] Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, Washington, DC 20307 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Hurst, Frank P.; Lee, Jessica J.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Agodoa, Lawrence Y.] NIDDKD, NIH, Bethesda, MD 20892 USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 17 TC 30 Z9 30 U1 0 U2 0 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD MAY PY 2011 VL 6 IS 5 BP 1192 EP 1197 DI 10.2215/CJN.05430610 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 761CK UT WOS:000290372600033 PM 21511837 ER PT J AU Belden, JB Lotufo, GR Chambliss, CK Fisher, JC Johnson, DR Boyd, RE Sims, JG AF Belden, Jason B. Lotufo, Guillerme R. Chambliss, C. Kevin Fisher, Jonathan C. Johnson, Dave R. Boyd, Robert E. Sims, Jerre G. TI Accumulation of (14)C-trinitrotoluene and related nonextractable (bound) residues in Eisenia fetida SO ENVIRONMENTAL POLLUTION LA English DT Article DE TNT; Earthworms; Bound residue; Nonextractable ID CATFISH ICTALURUS-PUNCTATUS; 2,4,6-TRINITROTOLUENE TNT; TRINITROTOLUENE TNT; AQUATIC ORGANISMS; EARTHWORM; SOIL; ANDREI; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIOCONCENTRATION; BIOACCUMULATION AB To determine if trinitrotoluene (TNT) forms nonextractable residues in earthworms and to measure the relative degree of accumulation as compared to TNT and its deaminated metabolites, Eisenia fetida was exposed to (14)C-TNT using dermal contact to filter paper or exposure to soil. Nonextractable residues made up 32-68% of total body burden depending on exposure media and deputation time. Parent TNT accounted for less than 3% of radioactivity, while ADNTs accounted for 7-38%. Elimination half-lives were 61-120 h for TNT, ADNTs, and DANTs, which was significantly lower than the half-lives found for nonextractable residues, 201-240 h. However, over 80% of the nonextractable residue was solubilized using weak acid (pH 2). Based on our findings that TNT accumulation occurs primarily as nonextractable residues, which have a longer half-life, and that nonextractable residues can be solubilized, we propose that nonextractable residues could be used as a selective biomarker for assessing TNT contamination. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Belden, Jason B.; Fisher, Jonathan C.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA. [Lotufo, Guillerme R.; Johnson, Dave R.; Boyd, Robert E.; Sims, Jerre G.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Chambliss, C. Kevin] Baylor Univ, Dept Chem, Waco, TX 76798 USA. RP Belden, JB (reprint author), Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA. EM jbelden@okstate.edu RI Belden, Jason/H-1764-2014; OI Belden, Jason/0000-0002-0432-7700; Chambliss, Kevin/0000-0003-3888-6890 FU Chief of Engineers FX Permission was granted by the Chief of Engineers to publish this material. The data presented were obtained from research conducted under the Army's Environmental Quality Technology Basic Research Program (Elizabeth Ferguson, Technical Director). We are grateful to Jessica Coleman for her laboratory assistance. NR 29 TC 10 Z9 10 U1 4 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD MAY PY 2011 VL 159 IS 5 SI SI BP 1363 EP 1368 DI 10.1016/j.envpol.2011.01.007 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 758UL UT WOS:000290192400045 PM 21295392 ER PT J AU West, D West, BJ AF West, D. West, B. J. TI Statistical origin of allometry SO EPL LA English DT Article ID POWER; METABOLISM; ANIMALS; BIOLOGY; MODEL; LAWS AB The allometry relationship (AR) between two properties of a living network X and Y is X = aY(b) where one or both of the variables is a measure of size and the allometry coefficient a and exponent b are fit to data. Many investigators have focused on determining the proper value of b entailed by an appropriate biological model, whereas others have argued that the allometry coefficient plays the more important role. Herein we use metabolic data to determine a probability density function (pdf) for the allometry coefficient P(a) with constant allometry exponent and a pdf for the allometry exponent Psi(b) with a constant allometry coefficient. The two distributions are found to imply that the allometry parameters co-vary and an explict functional relation between them is determined. The empirical pdf P(a) is a Pareto distribution and establishes an inconsistency between reductionistic and statistical models of the interspecies AR. This inconsistency is resolved using the probability calculus to establish that the scaling of the pdf is the proper origin of allometry. Copyright (c) EPLA, 2011 C1 [West, D.] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. [West, B. J.] USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. RP West, D (reprint author), Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. EM Bruce.J.West@us.army.mil RI West, Damien/F-8616-2012 OI West, Damien/0000-0002-4970-3968 NR 26 TC 4 Z9 4 U1 0 U2 8 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 J9 EPL-EUROPHYS LETT JI EPL PD MAY PY 2011 VL 94 IS 3 AR 38005 DI 10.1209/0295-5075/94/38005 PG 6 WC Physics, Multidisciplinary SC Physics GA 759FU UT WOS:000290226900032 ER PT J AU Johnson, BJ Melde, BJ Leska, IA Charles, PT Hewitt, AD AF Johnson, Brandy J. Melde, Brian J. Leska, Iwona A. Charles, Paul T. Hewitt, Alan D. TI Solid-phase extraction using hierarchical organosilicates for enhanced detection of nitroenergetic targets SO JOURNAL OF ENVIRONMENTAL MONITORING LA English DT Article ID ION MOBILITY SPECTROMETRY; PERIODIC MESOPOROUS ORGANOSILICAS; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; NANOPOROUS ORGANOSILICAS; NITROAROMATIC COMPOUNDS; ORGANIC GROUPS; CHANNEL WALLS; TNT DETECTION; TRACE LEVELS AB A novel porous organosilicate material was evaluated for application as a solid phase extraction sorbent for preconcentration of nitroenergetic targets from aqueous solution prior to HPLC analysis. The performance of the sorbent in spiked deionized water, groundwater, and surface water was evaluated. Targets considered included 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, RDX, HMX, and nitroglycerin. The sorbent was shown to provide improved performance over Sep-Pak RDX. The impact of complex matrices on target preconcentration by the sorbent was also found to be less dramatic than that observed for LiChrolut EN. The impact of changes in pH on target preconcentration was considered. Aqueous soil extracts generated from samples collected at sites of ordnance testing were also used to evaluate the materials. The results presented here demonstrate the potential of this novel sorbent for application as a solid phase extraction material for the preconcentration of nitroenergetic targets from aqueous solutions. C1 [Johnson, Brandy J.; Melde, Brian J.; Leska, Iwona A.; Charles, Paul T.] USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA. [Leska, Iwona A.] NOVA Res Inc, Alexandria, VA USA. [Hewitt, Alan D.] US Army Corps Engineers, Engineer Res & Dev Ctr, Hanover, NH USA. RP Johnson, BJ (reprint author), USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA. EM brandy.white@nrl.navy.mil; iwona.leska.ctr@nrl.navy.mil RI Johnson, Brandy/B-3462-2008 OI Johnson, Brandy/0000-0002-3637-0631 FU U.S. DoD [ER-1604] FX This research was sponsored by the U.S. DoD Strategic Environmental Research and Development Program (SERDP; ER-1604). We applied the SDC approach ("sequence-determines-credit") for determining the sequence of authors.45 The views expressed here are those of the authors and do not represent those of the U.S. Navy, the U.S. Department of Defense, or the U.S. Government. NR 45 TC 4 Z9 4 U1 0 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1464-0325 J9 J ENVIRON MONITOR JI J. Environ. Monit. PD MAY PY 2011 VL 13 IS 5 BP 1404 EP 1409 DI 10.1039/c1em10034c PG 6 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA 758LR UT WOS:000290166800030 PM 21409222 ER PT J AU Morgan, CA Russell, B McNeil, J Maxwell, J Snyder, PJ Southwick, SM Pietrzak, RH AF Morgan, Charles A., III Russell, Bartlett McNeil, Jeff Maxwell, Jeff Snyder, Peter J. Southwick, Steven M. Pietrzak, Robert H. TI Baseline Burnout Symptoms Predict Visuospatial Executive Function During Survival School Training in Special Operations Military Personnel SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY LA English DT Article DE Burnout; Stress; Cognition; Learning; Executive function; Military; Training ID SPATIAL WORKING-MEMORY; MAZE-LEARNING-TEST; COGNITIVE PERFORMANCE; CORTISOL RESPONSES; CLINICAL-TRIALS; STRESS; RESILIENCE; COMBAT; DISSOCIATION; DECREMENTS AB Burnout symptoms, which are characterized by exhaustion, cynicism, and a reduced sense of professional efficacy, may deleteriously affect cognitive function in military personnel. A total of 32 U.S. Military Special Operations personnel enrolled in Survival School completed measures of trauma history, dissociation, and burnout before training. They then completed the Groton Maze Learning Test (GMLT), a neuropsychological measure of integrative visuospatial executive function during three field-based phases of Survival School-enemy evasion, captivity/interrogation, and escape/release from captivity. Lower pre-training perceptions of professional efficacy were associated with reduced executive function during all of the field-based phases of Survival School, even after adjustment for years of education, cynicism, and baseline GMLT scores. Magnitudes of decrements in executive function in Marines with low efficacy relative to those with high efficacy increased as training progressed and ranged from .58 during enemy evasion to .99 during escape/release from captivity. Pre-training perceptions of burnout may predict visuospatial executive function during naturalistic training-related stress in military personnel. Assessment of burnout symptoms, particularly perceptions of professional efficacy, may help identify military personnel at risk for stress-related executive dysfunction. (JINS, 2011, 17, 494-501) C1 [Pietrzak, Robert H.] Yale Univ, Sch Med, Natl Ctr Posttraumat Stress Diso, Clin Neurosci Div,VA Connecticut Healthcare Syst, West Haven, CT 06516 USA. [Morgan, Charles A., III; Southwick, Steven M.; Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA. [Russell, Bartlett] Univ Maryland, Dept Kinesiol, Sch Publ Hlth, Cognit Motor Neurosci, College Pk, MD 20742 USA. [Russell, Bartlett] Univ Maryland, Dept Kinesiol, Ctr Adv Study Language, College Pk, MD 20742 USA. [Maxwell, Jeff] USA, Special Operat Command, Ft Bragg, NC USA. [Maxwell, Jeff] US Army Proving Grounds, Aberdeen, MD USA. [Snyder, Peter J.] Brown Univ, Rhode Isl Hosp, Providence, RI 02903 USA. [Snyder, Peter J.] Brown Univ, Warren Alpert Med Sch, Dept Neurol, Providence, RI 02903 USA. RP Pietrzak, RH (reprint author), Yale Univ, Sch Med, Natl Ctr Posttraumat Stress Diso, Clin Neurosci Div,VA Connecticut Healthcare Syst, 950 Campbell Ave 151E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu OI Snyder, Peter/0000-0003-0555-4654 FU Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder; CogState, Inc. FX The authors thank Capt. Joseph Clemmey, MAJ. Rob Sellars, Mr. Scott Kinder, SSGT. Pete Peterson, Mr. Ben Blick, Mr. Byron Sevario, and Alison Rivers. Their support and work significantly facilitated the completion of this project. Funding for this project was provided by the Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder. The opinions reflected in this study are not to be considered policy or guidance of the U.S. Government, U.S. Marine Corps, U.S. Navy, or the Department of Defense, but reflect solely the opinions of the authors. Dr. Pietrzak receives partial salary support from CogState, Inc., a cognitive test company that provided the cognitive test used in this study. Dr. Snyder serves as a consultant to this company. NR 40 TC 5 Z9 6 U1 2 U2 12 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1355-6177 J9 J INT NEUROPSYCH SOC JI J. Int. Neuropsychol. Soc. PD MAY PY 2011 VL 17 IS 3 BP 494 EP 501 DI 10.1017/S1355617711000221 PG 8 WC Clinical Neurology; Neurosciences; Psychiatry; Psychology SC Neurosciences & Neurology; Psychiatry; Psychology GA 757QU UT WOS:000290103600011 PM 21466738 ER PT J AU Hu, GL Ramesh, KT Cao, BY McCauley, JW AF Hu, Guangli Ramesh, K. T. Cao, Buyang McCauley, J. W. TI The compressive failure of aluminum nitride considered as a model advanced ceramic SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE AlN; Dynamic; Confining stress; Failure envelop; Deformation mechanism ID HIGH-STRAIN RATE; BRITTLE SOLIDS; HIGH-PRESSURE; UNIAXIAL COMPRESSION; DYNAMIC FRAGMENTATION; MECHANICAL-BEHAVIOR; LATERAL CONFINEMENT; CRACK-GROWTH; DAMAGE MODEL; FRACTURE AB Uniaxial quasi-static compression, uniaxial dynamic compression and confined dynamic compression experiments were performed to characterize the failure of Aluminum Nitride (AlN) using a servo hydraulic machine and a modified Kolsky bar set-up respectively. High-speed digital cameras are used to visualize the failure processes. A summary of the available experimental results, including that in the literature, shows that the compressive strength of the AIN is sensitive to strain rate in the range from 10(-3) to 10(3) s(-1), that the deviatoric strength of AIN is linearly dependent on pressure at low pressures and nearly independent of pressure above a transitional pressure (about 2 GPa). TEM characterization of fragments obtained after dynamic loading is used to characterize the deformation mechanisms in the AIN for varying confinement. The transition in the pressure dependent behavior is shown to be the result of a change of deformation mechanism. Classical wing crack micromechanics is used to predict the transition in the deformation mechanism, and to explain the observed behavior at low pressure. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Hu, Guangli; Ramesh, K. T.; Cao, Buyang] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [McCauley, J. W.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21078 USA. RP Ramesh, KT (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM ramesh@jhu.edu RI Hu, Guangli/F-2461-2011 OI Hu, Guangli/0000-0003-4751-1628 FU Army Research Laboratory under ARMAC-RTP [DAAD19-01-2-0003, W911NF-06-2-0006] FX This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems (CAMCS) at the Johns Hopkins University, supported by the Army Research Laboratory under the ARMAC-RTP Cooperative Agreement Nos. DAAD19-01-2-0003 and W911NF-06-2-0006. NR 65 TC 28 Z9 29 U1 2 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD MAY PY 2011 VL 59 IS 5 BP 1076 EP 1093 DI 10.1016/j.jmps.2011.02.003 PG 18 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 757FV UT WOS:000290071800010 ER PT J AU Mittermayr, R Hartinger, J Antonic, V Meinl, A Pfeifer, S Stojadinovic, A Schaden, W Redl, H AF Mittermayr, Rainer Hartinger, Joachim Antonic, Vlado Meinl, Alexandra Pfeifer, Sabine Stojadinovic, Alexander Schaden, Wolfgang Redl, Heinz TI Extracorporeal Shock Wave Therapy (ESWT) Minimizes Ischemic Tissue Necrosis Irrespective of Application Time and Promotes Tissue Revascularization by Stimulating Angiogenesis SO ANNALS OF SURGERY LA English DT Article ID SKIN-FLAP SURVIVAL; ENDOTHELIAL GROWTH-FACTOR; TOPICAL BLOOD PERFUSION; GENE-THERAPY; ANTIINFLAMMATORY ACTION; NITRIC-OXIDE; FACTOR-BETA; RAT MODEL; VEGF; RECRUITMENT AB Objective: To assess the time-dependent treatment effects of extracorporeal shock wave therapy (ESWT) in a standard rodent ischemic epigastric flap model. Background: ESWT has been shown to accelerate tissue repair in acute and chronic wounds and improve graft survival, but the mechanism remains incompletely understood. Methods: Shock waves at 0.1 mJ/mm(2) and 5 impulses/s (total 300 impulses) were applied to the epigastric flap ischemic region at various times pre-, immediately and 24 hours postischemic insult. Flap survival; vascular perfusion; vessel number; von Willebrand factor and smooth muscle actin protein expression as well as in vivo vascular endothelial growth factor receptor 2 expression were evaluated at 1, 3, and 7 days postoperatively in ESWT-treated and untreated controls. Results: Flap perfusion, microvessel number, and survival (through reduced flap contraction and necrosis) were significantly enhanced in the treated groups compared with controls, irrespective of timing of shock wave treatment (preischemia vs. postischemia). Vascular endothelial growth factor receptor 2 expression was dynamically upregulated in response to ESWT. Conclusion: Shock wave preconditioning and treatment postischemic insult improves skin flap survival through neovascularization and early upregulation of angiogenesis-related growth factors. C1 [Mittermayr, Rainer; Hartinger, Joachim; Meinl, Alexandra; Pfeifer, Sabine; Redl, Heinz] Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria. [Mittermayr, Rainer; Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria. [Antonic, Vlado; Stojadinovic, Alexander] Bernhard Gottlieb Univ, Sch Dent, Vienna, Austria. [Antonic, Vlado; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. [Meinl, Alexandra] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Stojadinovic, Alexander] Armed Forces Inst Pathol, Wound Biol & Translat Res Div, Washington, DC 20306 USA. RP Mittermayr, R (reprint author), Donaueschingenstr 13, A-1200 Vienna, Austria. EM Rainer.Mittermayr@trauma.lbg.ac.at FU Combat Wound Initiative Program FX Supported, in part, by the congressionally funded Combat Wound Initiative Program. NR 36 TC 47 Z9 49 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD MAY PY 2011 VL 253 IS 5 BP 1024 EP 1032 DI 10.1097/SLA.0b013e3182121d6e PG 9 WC Surgery SC Surgery GA 749ZD UT WOS:000289510600028 PM 21372687 ER PT J AU Moawad, FJ Maydonovitch, CL Veerappan, GR Bassett, JT Lake, JM Wong, RKH AF Moawad, Fouad J. Maydonovitch, Corinne L. Veerappan, Ganesh R. Bassett, John T. Lake, Jason M. Wong, Roy K. H. TI Esophageal Motor Disorders in Adults with Eosinophilic Esophagitis SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Eosinophilic esophagitis; Esophageal dysmotility; Esophageal motor disorders; Dysphagia ID DYSPHAGIA; CHILDREN; DYSMOTILITY; ACHALASIA; MANOMETRY AB An association between eosinophilic esophagitis (EoE) and esophageal motility disorders has been described in small studies. The aim of this study was to describe the prevalence of esophageal motor disorders in a large cohort of adults with EoE and examine whether an association exists between esophageal dysmotility and dysphagia. A retrospective review of esophageal manometry studies in adult EoE patients was performed. Tracings were reviewed for abnormalities including nutcracker esophagus and ineffective swallows, defined as low amplitude peristalsis (< 30 mmHg) or non-propagating contractions. Ineffective esophageal motility (IEM) was categorized as mild (30-40% ineffective swallows), moderate (50-60% ineffective swallows), and severe (a parts per thousand yen70% ineffective swallows). Dysphagia was graded on a 0-3 scale for frequency and severity. Seventy-five tracings from EoE patients were reviewed (85% male, mean age 41 +/- A 12 years). IEM was identified in 25 patients and categorized as mild (n = 13), moderate (n = 6), and severe (n = 6). Nutcracker esophagus was found in three patients. There was no significant difference in eosinophil count among the motility groups: normal 46.5 +/- A 3.1, mild IEM 56.9 +/- A 36.9, moderate IEM 45.5 +/- A 23.7, severe IEM 34.3 +/- A 12.6 (P = 0.157). In this cohort of EoE patients, the majority had normal esophageal motility studies, although a subset of these patients had some esophageal dysmotility. It is unlikely that esophageal dysmotility is a major contributing factor to dysphagia, although it is reasonable to consider esophageal manometry testing in EoE patients to identify potential abnormalities of the smooth muscle esophagus. C1 [Moawad, Fouad J.; Maydonovitch, Corinne L.; Veerappan, Ganesh R.; Lake, Jason M.; Wong, Roy K. H.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. [Moawad, Fouad J.; Veerappan, Ganesh R.; Lake, Jason M.; Wong, Roy K. H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Bassett, John T.] USN Hosp, Dept Med, Gastroenterol Serv, Jacksonville, FL USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Fouad.Moawad@us.army.mil NR 20 TC 10 Z9 10 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD MAY PY 2011 VL 56 IS 5 BP 1427 EP 1431 DI 10.1007/s10620-011-1655-5 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 755AO UT WOS:000289899200023 PM 21416245 ER PT J AU Poly, F Serichatalergs, O Schulman, M Ju, J Cates, CN Kanipes, M Mason, C Guerry, P AF Poly, Frederic Serichatalergs, Oralak Schulman, Marc Ju, Jennifer Cates, Cory N. Kanipes, Margaret Mason, Carl Guerry, Patricia TI Discrimination of Major Capsular Types of Campylobacter jejuni by Multiplex PCR SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID IRRITABLE-BOWEL-SYNDROME; GENOME SEQUENCE; STREPTOCOCCUS-PNEUMONIAE; CHEMICAL-STRUCTURE; DIARRHEAL DISEASE; POLYSACCHARIDE; SEROTYPES; OUTBREAK; INVASIVENESS; MUTAGENESIS AB The polysaccharide capsule (CPS) of Campylobacter jejuni is the major serodeterminant of the Penner serotyping scheme. There are 47 Penner serotypes of C. jejuni, 22 of which fall into complexes of related serotypes. A multiplex PCR method for determination of capsule types of Campylobacter jejuni which is simpler and more affordable than classical Penner typing was developed. Primers specific for each capsule type were designed on the basis of a database of gene sequences from the variable capsule loci of 8 strains of major serotypes sequenced in this study and 10 published sequences of other serotypes. DNA sequence analysis revealed a mosaic nature of the capsule loci, suggesting reassortment of genes by horizontal transfer, and demonstrated a high degree of conservation of genes within Penner complexes. The multiplex PCR can distinguish 17 individual serotypes in two PCRs with sensitivities and specificities ranging from 90 to 100% using 244 strains of known Penner type. C1 [Guerry, Patricia] USN, Enter Dis Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Serichatalergs, Oralak; Mason, Carl] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Cates, Cory N.; Kanipes, Margaret] N Carolina Agr & Tech Univ, Dept Chem, Greensboro, NC USA. RP Guerry, P (reprint author), USN, Enter Dis Dept, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM patricia.guerry@med.navy.mil RI Guerry, Patricia/A-8024-2011; OI MASON, CARL/0000-0002-3676-2811 FU U.S. Naval Medical Research and Development Command Work Unit [6000.RAD1.DA3.A0308] FX This work was supported by U.S. Naval Medical Research and Development Command Work Unit 6000.RAD1.DA3.A0308. NR 47 TC 19 Z9 19 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2011 VL 49 IS 5 BP 1750 EP 1757 DI 10.1128/JCM.02348-10 PG 8 WC Microbiology SC Microbiology GA 755OA UT WOS:000289941000008 PM 21411576 ER PT J AU Lonsway, DR Urich, SK Heine, HS McAllister, SK Banerjee, SN Schriefer, ME Patel, JB AF Lonsway, David R. Urich, Sandra K. Heine, Henry S. McAllister, Sigrid K. Banerjee, Shailen N. Schriefer, Martin E. Patel, Jean B. TI Comparison of Etest Method with Reference Broth Microdilution Method for Antimicrobial Susceptibility Testing of Yersinia pestis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID TRANSFERABLE PLASMID; PLAGUE; AGENTS; RESISTANCE; STRAINS AB The utility of Etest for antimicrobial susceptibility testing of Yersinia pestis was evaluated in comparison with broth microdilution and disk diffusion for eight agents. Four laboratories tested 26 diverse strains and found Etest to be reliable for testing antimicrobial agents used to treat Y. pestis, except for chloramphenicol and trimethoprim-sulfamethoxazole. Disk diffusion testing is not recommended. C1 [Lonsway, David R.; McAllister, Sigrid K.; Banerjee, Shailen N.; Patel, Jean B.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Urich, Sandra K.; Schriefer, Martin E.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Heine, Henry S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Lonsway, DR (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Mailstop G08,1600 Clifton Rd, Atlanta, GA 30333 USA. EM dul7@cdc.gov NR 25 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2011 VL 49 IS 5 BP 1956 EP 1960 DI 10.1128/JCM.00142-11 PG 5 WC Microbiology SC Microbiology GA 755OA UT WOS:000289941000038 PM 21411569 ER PT J AU Vyas, K Hospenthal, DR Mende, K Crum-Cianflone, NF AF Vyas, Kartavya Hospenthal, Duane R. Mende, Katrin Crum-Cianflone, Nancy F. TI Recurrent Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections in an HIV-Infected Person SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SOFT-TISSUE INFECTION; FIELD GEL-ELECTROPHORESIS; RISK-FACTORS; NASAL CARRIAGE; COLONIZATION; SKIN; COHORT; MRSA; SEX; MEN AB HIV-infected persons are at heightened risk for recurrent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, but there are limited data regarding the molecular characterization of these events. We describe an HIV-infected patient with 24 soft tissue infections and multiple colonization events. Molecular genotyping from 33 nonduplicate isolates showed all strains were USA300, Panton-Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME) positive, and genetically related. C1 [Vyas, Kartavya; Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92134 USA. [Vyas, Kartavya; Hospenthal, Duane R.; Mende, Katrin; Crum-Cianflone, Nancy F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Hospenthal, Duane R.; Mende, Katrin] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Infectious Disease Clinical Research Program (IDCRP); Department of Defense (DoD); National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 27 TC 5 Z9 7 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2011 VL 49 IS 5 BP 2047 EP 2053 DI 10.1128/JCM.02423-10 PG 7 WC Microbiology SC Microbiology GA 755OA UT WOS:000289941000063 PM 21389153 ER PT J AU Thakre, PR Lagoudas, DC Riddick, JC Gates, TS Frankland, SJV Ratcliffe, JG Zhu, J Barrera, EV AF Thakre, Piyush R. Lagoudas, Dimitris C. Riddick, Jaret C. Gates, Thomas S. Frankland, Sarah-Jane V. Ratcliffe, James G. Zhu, Jiang (John) Barrera, Enrique V. TI Investigation of the effect of single wall carbon nanotubes on interlaminar fracture toughness of woven carbon fiber-epoxy composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE carbon nanotubes; interlaminar fracture; delamination; carbon fiber composites; woven fabric composites; VARTM; DCB ID CANTILEVER BEAM TESTS; MODE-I; POLYMER COMPOSITES; REINFORCED COMPOSITES; CRACK-PROPAGATION; INTEGRATION; SIMULATION; BEHAVIOR; GLASS AB Single wall carbon nanotubes (SWCNTs) were introduced in the interlaminar region of woven carbon fiber-epoxy composites and the mode-I delamination behavior was investigated. Pristine (P-SWCNT) and functionalized (F-SWCNT) nanotubes were sprayed in the mid-plane of these laminates and delamination was initiated using a teflon pre-crack insert. The composite laminates were produced using vacuum-assisted resin transfer molding process. The interlaminar fracture toughness (ILFT) represented by mode-I critical strain energy release rate (G(Ic)) for the initiation of delamination was measured using double cantilever beam tests. The specimens with pristine nanotubes and functionalized nanotubes showed a small effect on the ILFT. The specimens with P-SWCNTs showed stable crack growth and the potential for enhanced crack bridging along with slightly higher GIc than F-SWCNT specimens. Scanning electron microscopy images showed enhanced fiber-matrix interfacial bonding in the specimens with F-SWCNTs. However, large unstable crack propagation was observed in these F-SWCNT specimens from load-displacement curves and crack propagation videos. This research helps in understanding the differences in mechanisms by addition of functionalized and unfunctionalized (pristine) nanotubes to the woven carbon fiber-epoxy matrix composite laminates. C1 [Thakre, Piyush R.; Lagoudas, Dimitris C.] Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77840 USA. [Riddick, Jaret C.] USA, Res Lab, Aberdeen, MD 21005 USA. [Gates, Thomas S.] NASA, Langley Res Ctr, Durabil Damage Tolerance & Reliabil Branch, Hampton, VA 23681 USA. [Frankland, Sarah-Jane V.; Ratcliffe, James G.] Natl Inst Aerosp, Hampton, VA 23666 USA. [Zhu, Jiang (John)] NanoRidge Mat Inc, Houston, TX 77023 USA. [Barrera, Enrique V.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RP Lagoudas, DC (reprint author), Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77840 USA. EM lagoudas@tamu.edu OI Lagoudas, Dimitris/0000-0002-0194-5933 FU NASA [NCC-1-02038] FX This study was supported by Texas Institute for Intelligent Bio-Nano Materials and Structures for Aerospace Vehicles funded by NASA Cooperative agreement no. NCC-1-02038. The authors would like to thank Mr James Baughman from Lockheed Martin for helping with SEM Fractography and Dr Roberto J. Cano from NASA-LARC for providing the carbon fiber material. We would also like to thank Dr Gary-Don Seidel for useful discussions on this article. This study was conducted while Dr Gates was the Branch Head of the DDTR Branch at NASA LaRC and his contributions in bringing the team together for this project were essential, in addition to his technical participation in this study. Authors would also like to thank Dr Edward Glaessgen for helping with the article review process at NASA. NR 49 TC 23 Z9 23 U1 1 U2 29 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD MAY PY 2011 VL 45 IS 10 BP 1091 EP 1107 DI 10.1177/0021998310389088 PG 17 WC Materials Science, Composites SC Materials Science GA 755XG UT WOS:000289972700003 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Moro War: How America Battled a Muslim Insurgency in the Philippine Jungle 1902-1913 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 2011 VL 136 IS 8 BP 91 EP 91 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 755IU UT WOS:000289923500138 ER PT J AU Blazeck, A Klem, ML Miller, TH AF Blazeck, Alice Klem, Mary Lou Miller, Thomas H. TI Building Evidence-Based Practice Into the Foundations of Practice SO NURSE EDUCATOR LA English DT Article AB The Institute of Medicine asserts that evidence-based practice can become a reality because the tools to find the best evidence are available. However, teaching the naive sophomore how to use these tools while ensuring that this first search experience is successful from both the student and the instructor standpoint is complex. The authors describe an assignment that ensures students will master the steps needed to locate quality evidence. C1 [Blazeck, Alice; Miller, Thomas H.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15216 USA. [Klem, Mary Lou] Univ Pittsburgh, Hlth Sci Lib Syst, Pittsburgh, PA 15216 USA. [Miller, Thomas H.] USA, Washington, DC USA. RP Blazeck, A (reprint author), Univ Pittsburgh, Sch Nursing, 320 Victoria, Pittsburgh, PA 15216 USA. EM blazecka@pitt.edu NR 3 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-3624 J9 NURS EDUC JI Nurs. Educ. PD MAY-JUN PY 2011 VL 36 IS 3 BP 124 EP 127 DI 10.1097/NNE.0b013e31820b4fe9 PG 4 WC Nursing SC Nursing GA 752DV UT WOS:000289670100010 PM 21502848 ER PT J AU Garcia-Reyero, N Habib, T Pirooznia, M Gust, KA Gong, P Warner, C Wilbanks, M Perkins, E AF Garcia-Reyero, Natalia Habib, Tanwir Pirooznia, Mehdi Gust, Kurt A. Gong, Ping Warner, Chris Wilbanks, Mitchell Perkins, Edward TI Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics SO ECOTOXICOLOGY LA English DT Article DE Genomics; Meta-analysis; Species comparison; GABA(A) receptor; RDX ID BOBWHITE COLINUS-VIRGINIANUS; SET ENRICHMENT ANALYSIS; EXPRESSION PROFILES; PROTEIN-INTERACTION; GABA(A) RECEPTORS; OXIDATIVE STRESS; EISENIA-FOETIDA; GENE-EXPRESSION; GLUTATHIONE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE AB At military training sites, a variety of pollutants such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), may contaminate the area originating from used munitions. Studies investigating the mechanism of toxicity of RDX have shown that it affects the central nervous system causing seizures in humans and animals. Environmental pollutants such as RDX have the potential to affect many different species, therefore it is important to establish how phylogenetically distant species may respond to these types of emerging pollutants. In this paper, we have used a transcriptional network approach to compare and contrast the neurotoxic effects of RDX among five phylogenetically disparate species: rat (Sprague-Dawley), Northern bobwhite quail (Colinus virginianus), fathead minnow (Pimephales promelas), earthworm (Eisenia fetida), and coral (Acropora formosa). Pathway enrichment analysis indicated a conservation of RDX impacts on pathways related to neuronal function in rat, Northern bobwhite quail, fathead minnows and earthworm, but not in coral. As evolutionary distance increased common responses decreased with impacts on energy and metabolism dominating effects in coral. A neurotransmission related transcriptional network based on whole rat brain responses to RDX exposure was used to identify functionally related modules of genes, components of which were conserved across species depending upon evolutionary distance. Overall, the meta-analysis using genomic data of the effects of RDX on several species suggested a common and conserved mode of action of the chemical throughout phylogenetically remote organisms. C1 [Gust, Kurt A.; Warner, Chris; Wilbanks, Mitchell; Perkins, Edward] USA, Environm Lab, Engineer Res & Dev Ctr, ERDC EP P, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Habib, Tanwir] Badger Tech Serv, Vicksburg, MS 39180 USA. [Pirooznia, Mehdi] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Gong, Ping] SpecPro Inc, Vicksburg, MS 39180 USA. RP Perkins, E (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, ERDC EP P, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Edward.J.Perkins@usace.army.mil OI Pirooznia, Mehdi/0000-0002-4210-6458 FU US Army FX The authors would like to thank Lynn Escalon, Natalie Barker, Xin Guan, and Robby Body who were responsible for generating the data presented here. This work was funded by the US Army Environmental Quality Research Program. Permission for publishing this information has been granted by the Chief of Engineers. NR 64 TC 20 Z9 20 U1 2 U2 28 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 EI 1573-3017 J9 ECOTOXICOLOGY JI Ecotoxicology PD MAY PY 2011 VL 20 IS 3 BP 580 EP 594 DI 10.1007/s10646-011-0623-3 PG 15 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 754IP UT WOS:000289848600011 PM 21516383 ER PT J AU Matheny, RW Nindl, BC AF Matheny, Ronald W., Jr. Nindl, Bradley C. TI Loss of IGF-IEa or IGF-IEb Impairs Myogenic Differentiation SO ENDOCRINOLOGY LA English DT Article ID GROWTH-FACTOR-I; MYOSIN HEAVY-CHAIN; (IGF)-I E-PEPTIDES; SKELETAL-MUSCLE; GENE-EXPRESSION; MYOBLAST DIFFERENTIATION; BINDING-PROTEINS; C2C12 MYOBLASTS; INSULIN; HYPERTROPHY AB Actions of protein products resulting from alternative splicing of the Igf1 gene have received increasing attention in recent years. However, the significance and functional relevance of these observations remain poorly defined. To address functions of IGF-I splice variants, we examined the impact of loss of IGF-IEa and IGF-IEb on the proliferation and differentiation of cultured mouse myoblasts. RNA interference-mediated reductions in total IGF-I, IGF-IEa alone, or IGF-IEb alone had no effect on cell viability in growth medium. However, cells deficient in total IGF-I or IGF-IEa alone proliferated significantly slower than control cells or cells deficient in IGF-IEb in serum-free media. Simultaneous loss of both or specific loss of either splice variant significantly inhibited myosin heavy chain (MyHC) immunoreactivity by 70-80% (P < 0.01) under differentiation conditions (48 h in 2% horse serum) as determined by Western immunoblotting. This loss in protein was associated with reduced MyHC isoform mRNAs, because reductions in total IGF-I or IGF-IEa mRNA significantly reduced MyHC mRNAs by approximately 50-75% (P < 0.05). Loss of IGF-IEb also reduced MyHC isoform mRNA significantly, with the exception of Myh7, but to a lesser degree (similar to 20-40%, P < 0.05). Provision of mature IGF-I, but not synthetic E peptides, restored Myh3 expression to control levels in cells deficient in IGF-IEa or IGF-IEb. Collectively, these data suggest that IGF-I splice variants may regulate myoblast differentiation through the actions of mature IGF-I and not the E peptides. (Endocrinology 152: 1923-1934, 2011) C1 [Matheny, Ronald W., Jr.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Matheny, RW (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM ronald.matheny@us.army.mil RI Matheny, Ronald/I-9336-2012 OI Matheny, Ronald/0000-0001-7378-0560 FU United States Army Research Institute of Environmental Medicine FX This work was supported by an appointment to the Postgraduate Research Participation Program at the United States Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the United States Department of Energy and United States Army Medical Research and Materiel Command (R. W. M.). NR 62 TC 20 Z9 21 U1 1 U2 4 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD MAY PY 2011 VL 152 IS 5 BP 1923 EP 1934 DI 10.1210/en.2010-1279 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 753OJ UT WOS:000289788500024 PM 21406500 ER PT J AU Bellar, D Kamimori, GH Glickman, EL AF Bellar, David Kamimori, Gary H. Glickman, Ellen L. TI THE EFFECTS OF LOW-DOSE CAFFEINE ON PERCEIVED PAIN DURING A GRIP TO EXHAUSTION TASK SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE analgesic; RPE; muscle pain; exhaustive exercise ID PREDICTING BODY DENSITY; GENERALIZED EQUATIONS; HEALTHY-VOLUNTEERS; CYCLING EXERCISE; MUSCLE PAIN; PERFORMANCE; INGESTION; METABOLISM AB Bellar, D, Kamimori, GH, and Glickman, EL. The effects of low-dose caffeine on perceived pain during a grip to exhaustion task. J Strength Cond Res 25(5): 1225-1228, 2011-This double-blind, placebo-controlled, within-subject experiment examined the effects of low-dose caffeine on pain reported during an exhaustive grip task. The grip task consisted of holding a metal block attached to standard Olympic weight plates with the arm at the side until the participants could no longer maintain their grip. Apparently healthy recreationally trained college-aged adults (men, n = 5; women, n = 5) were given either a piece of Stay Alert (TM) gum that delivered 85% of the effective dose of 100 mg of caffeine in 5 minutes or an identical placebo gum that contained no caffeine. Subsequently, pain perception and ratings of perceived exertion were recorded during an exhaustive grip task every 15 seconds and the overall time to exhaustion. No significant difference was found in time to exhaustion between treatments. A significant main effect of treatment for reported pain (p < 0.001, Phi = 0.377) was observed. Thus, in a population of recreationally trained college-aged adults, low-dose caffeine may attenuate the individual's perception of pain during a grip to exhaustion task. C1 [Bellar, David] Univ Louisiana Lafayette, Dept Kinesiol, Lafayette, LA 70504 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Dept Behav Biol, Rockville, MD USA. [Glickman, Ellen L.] Kent State Univ, Sch Hlth Sci, Kent, OH 44242 USA. RP Bellar, D (reprint author), Univ Louisiana Lafayette, Dept Kinesiol, Lafayette, LA 70504 USA. EM davidbellar@mac.com NR 23 TC 6 Z9 6 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAY PY 2011 VL 25 IS 5 BP 1225 EP 1228 DI 10.1519/JSC.0b013e3181d9901f PG 4 WC Sport Sciences SC Sport Sciences GA 753KL UT WOS:000289772000005 PM 21522070 ER PT J AU Eller, MA Koehler, RN Kijak, GH Eller, LA Guwatudde, D Marovich, MA Michael, NL de Souza, MS Wabwire-Mangen, F Robb, ML Currier, JR Sandberg, JK AF Eller, Michael A. Koehler, Rebecca N. Kijak, Gustavo H. Eller, Leigh Anne Guwatudde, David Marovich, Mary A. Michael, Nelson L. de Souza, Mark S. Wabwire-Mangen, Fred Robb, Merlin L. Currier, Jeffrey R. Sandberg, Johan K. TI Human Immunodeficiency Virus Type 1 Infection Is Associated with Increased NK Cell Polyfunctionality and Higher Levels of KIR3DL1(+) NK Cells in Ugandans Carrying the HLA-B Bw4 Motif SO JOURNAL OF VIROLOGY LA English DT Article ID NATURAL-KILLER-CELLS; CLASS-I LIGANDS; HIV-INFECTION; DISEASE PROGRESSION; ALLELES; KIR; AIDS; EXPRESSION; PROTECTION; DIVERSITY AB Natural killer (NK) cells are important innate effector cells controlled by an array of activating and inhibitory receptors. Some alleles of the inhibitory killer-cell immunoglobulin-like receptor KIR3DL1 in combination with its HLA class I ligand Bw4 have been genetically associated with slower HIV-1 disease progression. Here, we observed that the presence of HLA-B Bw4 was associated with elevated frequencies of KIR3DL1(+) CD56(dim) NK cells in chronically HIV-1-infected individuals from the rural district of Kayunga, Uganda. In contrast, levels of KIR2DL1(+) CD56(dim) NK cells were decreased, and levels of KIR2DL3(+) CD56(dim) NK cells were unchanged in infected subjects carrying their respective HLA-C ligands. Furthermore, the size of the KIR3DL1(+) NK cell subset correlated directly with viral load, and this effect occurred only in HLA-B Bw4(+) patients, suggesting that these cells expand in response to viral replication but may have relatively poor antiviral capacity. In contrast, no association with viral load was present for KIR2DL1(+) and KIR2DL3(+) NK cells. Interestingly, chronic HIV-1 infection was associated with an increased polyfunctional response in the NK cell compartment, and, upon further investigation, KIR3DL1(+) CD56(dim) NK cells exhibited a significantly increased functional response in the patients carrying HLA-B Bw4. These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif. C1 [Eller, Michael A.; Koehler, Rebecca N.; Kijak, Gustavo H.; Eller, Leigh Anne; Marovich, Mary A.; Michael, Nelson L.; de Souza, Mark S.; Robb, Merlin L.; Currier, Jeffrey R.] US Mil HIV Res Program, Rockville, MD 20850 USA. [Eller, Michael A.; Sandberg, Johan K.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, S-14186 Stockholm, Sweden. [Eller, Michael A.; Eller, Leigh Anne; Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Eller, MA (reprint author), US Mil HIV Res Program, 13 Taft Court,Suite 200, Rockville, MD 20850 USA. EM meller@hivresearch.org OI Sandberg, Johan/0000-0002-6275-0750 FU U.S. Army Medical Research and Materiel Command and its Cooperative Agreement with Henry M. Jackson Foundation for the Advancement of Military Medicine with Division of AIDS, National Institute of Allergy and Infectious Diseases [W81XWH-04-02-0005, 1Y-A1-26-42-07]; National Institutes of Health; Swedish Research Council; Swedish Physicians against AIDS Foundation; Swedish Cancer Foundation; Karolinska Institutet FX This work was supported by the U.S. Army Medical Research and Materiel Command and its Cooperative Agreement (W81XWH-04-02-0005) with the Henry M. Jackson Foundation for the Advancement of Military Medicine and with an interagency agreement (1Y-A1-26-42-07) with the Division of AIDS, National Institute of Allergy and Infectious Diseases, and the National Institutes of Health. The work was also supported by the Swedish Research Council, the Swedish Physicians against AIDS Foundation, the Swedish Cancer Foundation, and Karolinska Institutet. NR 51 TC 10 Z9 10 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2011 VL 85 IS 10 BP 4802 EP 4811 DI 10.1128/JVI.00111-11 PG 10 WC Virology SC Virology GA 753NZ UT WOS:000289787300017 PM 21411516 ER PT J AU Goff, AJ Chapman, J Foster, C Wlazlowski, C Shamblin, J Lin, K Kreiselmeier, N Mucker, E Paragas, J Lawler, J Hensley, L AF Goff, Arthur J. Chapman, Jennifer Foster, Chad Wlazlowski, Carly Shamblin, Joshua Lin, Kenny Kreiselmeier, Norman Mucker, Eric Paragas, Jason Lawler, James Hensley, Lisa TI A Novel Respiratory Model of Infection with Monkeypox Virus in Cynomolgus Macaques SO JOURNAL OF VIROLOGY LA English DT Article ID SMALLPOX; CONGO; PATHOLOGY; ST-246 AB Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model. C1 [Goff, Arthur J.; Chapman, Jennifer; Wlazlowski, Carly; Shamblin, Joshua; Lin, Kenny; Mucker, Eric; Hensley, Lisa] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Foster, Chad] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Kreiselmeier, Norman] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Paragas, Jason; Lawler, James] NIAID, Integrated Res Facil, NIH, Frederick, MD USA. RP Goff, AJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Viral Therapeut Branch, 1425 Porter St,903Q, Ft Detrick, MD 21702 USA. EM Arthur.Goff@amedd.army.mil FU Department of Homeland Security/National Biodefense and Countermeasures Center [RSRD-05-00378] FX This work was supported by Department of Homeland Security/National Biodefense and Countermeasures Center, Contract number RSRD-05-00378. NR 18 TC 32 Z9 33 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2011 VL 85 IS 10 BP 4898 EP 4909 DI 10.1128/JVI.02525-10 PG 12 WC Virology SC Virology GA 753NZ UT WOS:000289787300026 PM 21389129 ER PT J AU Bondugula, R Wallqvist, A Lee, MS AF Bondugula, Rajkumar Wallqvist, Anders Lee, Michael S. TI Can computationally designed protein sequences improve secondary structure prediction? SO PROTEIN ENGINEERING DESIGN & SELECTION LA English DT Article DE computational protein design; fuzzy nearest neighbor; RosettaDesign; secondary structure prediction ID RECOGNITION; DATABASE; CLASSIFICATION; STRATEGIES; ROSETTA; FAMILY; SCOP; TOOL AB Computational sequence design methods are used to engineer proteins with desired properties such as increased thermal stability and novel function. In addition, these algorithms can be used to identify an envelope of sequences that may be compatible with a particular protein fold topology. In this regard, we hypothesized that sequence-property prediction, specifically secondary structure, could be significantly enhanced by using a large database of computationally designed sequences. We performed a large-scale test of this hypothesis with 6511 diverse protein domains and 50 designed sequences per domain. After analysis of the inherent accuracy of the designed sequences database, we realized that it was necessary to put constraints on what fraction of the native sequence should be allowed to change. With mutational constraints, accuracy was improved vs. no constraints, but the diversity of designed sequences, and hence effective size of the database, was moderately reduced. Overall, the best three-state prediction accuracy (Q(3)) that we achieved was nearly a percentage point improved over using a natural sequence database alone, well below the theoretical possibility for improvement of 8-10 percentage points. Furthermore, our nascent method was used to augment the state-of-the-art PSIPRED program by a percentage point. C1 [Bondugula, Rajkumar; Wallqvist, Anders; Lee, Michael S.] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Lee, Michael S.] USA, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Lee, MS (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM michael.lee@amedd.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU US Department of Defense under the High Performance Computing Software Applications Institutes Initiative FX This work was sponsored by the US Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes Initiative. NR 33 TC 4 Z9 4 U1 1 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1741-0126 J9 PROTEIN ENG DES SEL JI Protein Eng. Des. Sel. PD MAY PY 2011 VL 24 IS 5 BP 455 EP 461 DI 10.1093/protein/gzr003 PG 7 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 754FD UT WOS:000289838900006 PM 21282334 ER PT J AU Gruber, DD Warner, WB Lombardini, ED Zahn, CM Buller, JL AF Gruber, Daniel D. Warner, William B. Lombardini, Eric D. Zahn, Christopher M. Buller, Jerome L. TI Anatomical and Histological Examination of the Porcine Vagina and Supportive Structures: In Search of an Ideal Model for Pelvic Floor Disorder Evaluation and Management SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE swine; anatomy; vagina; model; histology AB Objective: The objective of the study was to examine the anatomy and histology of the swine vagina and adjacent supportive structures in comparison to human tissues to determine the potential utility of this model for pelvic floor disorder evaluation and management. Methods: This is a descriptive study of the gross anatomy and histology of the swine vagina, uterosacral ligament, cardinal ligament, and rectovaginal space. Tissue was collected from 6 different sites in each of the 6 animals, processed, and stained with hematoxylin-eosin, Masson trichrome, and van Gieson and evaluated by both gynecologic and veterinary pathologists. Results: Porcine tissues were similar to the human vagina and supporting structures. The origin, insertion, and course of the uterosacral and cardinal ligaments appeared similar to those in humans. Histologically, both the porcine and human vagina and rectum consist of a mucosal, muscular, and adventitial layers. The swine vaginal smooth muscle is arranged in an inner circular and outer longitudinal manner. Collagen, elastin, and smooth muscle were identified in 5 sites. Collagen was highest in the cardinal compared with the uterosacral ligament (P = 0.03), whereas elastin was highest in the uterosacral ligament. The vaginal epithelium measured approximately 40 mu m at the vaginal cuff and 50 to 200 Km at anterior and posterior vagina. The swine vagina appeared thinner and contained less elastin. The rectovaginal region contained a smooth muscle layer leading to a thin adventitial layer. Conclusions: The swine vagina and adjacent supportive structures appear to be grossly and histologically similar to human vaginal anatomy, and these similarities could lead to further investigation of the porcine model in the study of pelvic support and support disorders. C1 [Gruber, Daniel D.; Warner, William B.; Buller, Jerome L.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Lombardini, Eric D.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. [Zahn, Christopher M.; Buller, Jerome L.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. RP Gruber, DD (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Bldg 2,Rm 6764,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM ddgruber1@gmail.com FU Medical Research and Material Command, Telemedicine and Advanced Technology Research Center FX Funding was provided through Medical Research and Material Command, Telemedicine and Advanced Technology Research Center. This is a Uniformed Services University IACUC approved study (protocol OBG-09-576). NR 16 TC 4 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAY-JUN PY 2011 VL 17 IS 3 BP 110 EP 114 DI 10.1097/SPV.0b013e318214b1a6 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35WO UT WOS:000209176200002 PM 22453780 ER PT J AU von Pechmann, WS Aungst, MJ Gruber, DD Ghodsi, PM Cruess, DF Griffis, KR AF von Pechmann, Walter S. Aungst, Matthew J. Gruber, Daniel D. Ghodsi, Pari M. Cruess, David F. Griffis, Kenneth R. TI A Pilot Study on Vaginally Assisted Laparoscopic Sacrocolpopexy for Patients With Uterovaginal Prolapse SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE laparoscopy; laparoscopic sacrocolpopexy; time; mesh; pelvic organ prolapse AB Objectives: The primary objective of this pilot study was to compare the short-term anatomic outcomes and complication rates of vaginally assisted laparoscopic sacrocolpopexy (VALS) with those of conventional laparoscopic sacrocolpopexy (LS) in patients undergoing concurrent hysterectomy. The secondary objective was to compare operative times of the 2 different techniques. Methods: This is a retrospective pilot study comparing VALSVa method using transvaginal mesh attachment to the vaginal apexVto conventional LS in patients undergoing concurrent hysterectomy. Results: Forty-four women underwent VALS, and 26 women underwent LS. There was no significant difference in intraoperative complication rates (2.3% vs 3.8%, not statistically significant), postoperative complication rates (4.5% vs 0.0%, P = 0.526), mesh extrusion rates (2.3% vs 0%, not statistically significant), or postoperative pelvic organ prolapse quantification scores. The mean total operative time was 55 minutes shorter for the VALS group (215.2 [SD, 41.0] minutes) than the LS group (269.7 [SD, 55.6] minutes; P < 0.001). Conclusions: There was no significant difference in short-term anatomic outcomes or complication rates between groups. Vaginally assisted LS was associated with significantly shorter operative times than conventional LS. C1 [von Pechmann, Walter S.; Ghodsi, Pari M.] George Washington Univ, Sch Med, Dept Obstet & Gynecol, Washington, DC USA. [Aungst, Matthew J.; Gruber, Daniel D.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Cruess, David F.] Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, Bethesda, MD 20814 USA. [Griffis, Kenneth R.] Kaiser Permanente, Urogynecol & Reconstruct Pelv Surg, Fontana, CA USA. RP von Pechmann, WS (reprint author), 3289 Woodburn Rd 130, Annandale, VA 22003 USA. EM wvonpechmann@yahoo.com NR 15 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAY-JUN PY 2011 VL 17 IS 3 BP 115 EP 119 DI 10.1097/SPV.0b013e318216379d PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35WO UT WOS:000209176200003 PM 22453781 ER PT J AU Smith, TM Trowbridge, ER Pastore, LM Smith, SC Brennan, MC Dooley, Y Matthews, CA Ozel, B Sutkin, G Hullfish, KL AF Smith, Tovia Martirosian Trowbridge, Elisa R. Pastore, Lisa M. Smith, Steven C. Brennan, Matthew C. Dooley, Yashika Matthews, Catherine A. Ozel, Begum Sutkin, Gary Hullfish, Kathie L. TI The Multicenter Urogynecology Study on Education: Associations Between Educational Outcomes and Clerkship Center Characteristics SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE medical student education; clerkship; urogynecology; female pelvic medicine and reconstructive surgery; center characteristics AB Objective: The objective of the study was to examine the effect of center characteristics on educational experiences and female pelvic medicine knowledge changes in third-year students at 6 medical schools. Methods: In this secondary analysis of data acquired during a prospective, multicenter study conducted from May 2008 through June 2009, preclerkship and postclerkship third-year medical students scored their knowledge of 12 female pelvic medicine topics and 4 office procedures (knowledge scores [KSs]). Postclerkship, students also reported the number and type of learning experiences they had encountered. Participating investigators provided data on length of clerkship, number of residents, number of fellowship-trained urogynecologists, presence of a fellowship program, clerkship grading system type, presence of a urogynecology clerkship rotation, and presence of a urogynecology lecture. Analyses used Wilcoxon tests/Spearman correlation, with an alpha = 0.05. Results: Paired preclerkship and postclerkship survey datawere available for 323 students. Increased numbers of learning experiences were positively associated with number of clerkship weeks (r(s) = 0.22, P < 0.001), presence of a urogynecology rotation (P = 0.03), and urogynecology lecture (P < 0.001). Knowledge scores were positively associated with the number of fellowship-trained urogynecology faculty (r(s) = 0.17, P = 0.002) and grading system (letter grades 9 pass/fail) (P < 0.001). Knowledge scores were negatively associated with increasing numbers of residents (r(s) = -0.29, P < 0.001) and presence of a urogynecology fellowship program (P < 0.001). The center characteristics of fellowship program and number of residents were highly correlated (r(s) = 0.74, P < 0.001); thus, multivariate modeling was not performed. Conclusions: The presence of fellowship-trained faculty, urogynecology rotation, longer duration of clerkship, and urogynecology lecture were positively correlated with higher subjective KSs. The inverse association of KS with increased resident number and presence of fellowship was an unexpected finding. C1 [Smith, Tovia Martirosian; Trowbridge, Elisa R.; Pastore, Lisa M.; Smith, Steven C.; Hullfish, Kathie L.] Univ Virginia, Charlottesville, VA USA. [Brennan, Matthew C.] Univ New Mexico, Albuquerque, NM 87131 USA. [Dooley, Yashika] Brooke Army Med Ctr, San Antonio, TX USA. [Matthews, Catherine A.] Univ N Carolina, Chapel Hill, NC USA. [Ozel, Begum] Univ So Calif, Los Angeles, CA USA. [Sutkin, Gary] Univ Pittsburgh, Pittsburgh, PA USA. RP Smith, TM (reprint author), Univ Michigan, Womens Hosp L4000, Dept Obstet & Gynecol, 1500 E Med Ctr Dr,SPC 5276,929 5 St, Ann Arbor, MI 48109 USA. EM toviasmith@gmail.com FU AUGS Multicenter Educational Research Initiative FX The authors thank the AUGS Multicenter Educational Research Initiative for the support, which helped fund this research. NR 16 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAY-JUN PY 2011 VL 17 IS 3 BP 134 EP 138 DI 10.1097/SPV.0b013e31821cf2b3 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35WO UT WOS:000209176200007 PM 22453785 ER PT J AU McVearry, ME Warner, WB AF McVearry, Mary E. Warner, William B. TI Use of Physical Therapy to Augment Dilator Treatment for Vaginal Agenesis SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE dilator; physical therapy; vaginal agenesis AB Objective: Dilator therapy has been used successfully for many years to treat vaginal agenesis. Our objective was to show how established physical therapy techniques can be used to augment dilator therapy. Methods: A 36-year-old woman desiring nonsurgical management of vaginal agenesis was instructed in the use of vaginal dilators by a pelvic-floor physical therapist. Manual stretching of the vaginal tissues was performed during office visits after application of heat and therapeutic ultrasound to the perineum. In addition, the patient's husband was taught how to perform the vaginal stretching at home in conjunction with dilator therapy. Results: The patient was able to attempt intercourse after 6 weeks of treatment and achieved full penetration by 9 weeks. At the completion of treatment, she scored 31.9 on the Female Sexual Function Index. The patient and her husband were very satisfied with the treatment approach, especially the encouragement and guidance received in physical therapy. Conclusions: By using established physical therapy techniques in conjunction with dilator therapy, a faster time to intercourse may be achieved with high patient and spouse satisfaction. We recommend the involvement of a physical therapist specializing in the pelvic floor as an adjunct to standard dilator therapy in the treatment of vaginal agenesis. C1 [McVearry, Mary E.; Warner, William B.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. RP Warner, WB (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM homegrown95@yahoo.com NR 25 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAY-JUN PY 2011 VL 17 IS 3 BP 153 EP 156 DI 10.1097/SPV.0b013e31821bcd83 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35WO UT WOS:000209176200012 PM 22453790 ER PT J AU Wilken, JM Sinitski, EH Bagg, EA AF Wilken, Jason M. Sinitski, Emily H. Bagg, Elizabeth A. TI The role of lower extremity joint powers in successful stair ambulation SO GAIT & POSTURE LA English DT Article DE Stairs; Plantarflexors; Ankle power; Center of mass ID BIOMECHANICAL ANALYSIS; WALKING; DESCENT; ASCENT AB Ascending stairs is an important functional activity that is affected by lower extremity pathology including amputation. Although several studies have demonstrated stair ascent is more challenging than level ground walking, our understanding of the mechanics remains limited. The purpose of this study was to determine the association between lower extremity joint power generation and vertical COM acceleration (COM(A)) during stair ascent. Twenty-two healthy individuals underwent a biomechanical gait assessment while walking up a 16-step instrumented staircase. The association between the peak joint powers and peak COMA during stance were assessed with respect to timing and magnitude. With respect to timing, peak ankle joint power was highly correlated with peak COM(A) (R(2) = 0.93), while peak knee and hip joint powers demonstrated limited association with COM(A) (R(2) = 0.41 and 0.08, respectively). Only the magnitude of peak ankle power was associated with peak COM(A) (R(2) = 0.3). Significant temporal and magnitude associations between peak ankle joint power and peak COM(A) suggest ankle power is a key contributor to COM(A). Although peak knee joint power and COM(A) are temporally associated, the association is weaker and the occurrence of peak joint knee power is nearly 10% after peak COM(A), suggesting knee joint power plays a lesser role in COM(A). These combined findings indicate the role of trail limb ankle plantarflexors should be recognized in the stair ascent cycle definition and demonstrate the potential importance of a power generated by the ankle plantarflexors to normalize stair ascent performance following lower extremity amputation. Published by Elsevier B.V. C1 [Wilken, Jason M.; Sinitski, Emily H.; Bagg, Elizabeth A.] Brooke Army Med Ctr, Mil Performance Lab, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Mil Performance Lab, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM Jason.Wilken@us.army.mil OI Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX Support provided by the Military Amputee Research Program (to JMW). NR 10 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD MAY PY 2011 VL 34 IS 1 BP 142 EP 144 DI 10.1016/j.gaitpost.2011.03.015 PG 3 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 785OB UT WOS:000292237200026 PM 21482112 ER PT J AU Clark, P Wroblewski, T AF Clark, Paul Wroblewski, Tanya TI UNEXPECTED MRI FINDINGS IN A 24 YEAR-OLD MALE WITH NEWLY DIAGNOSED ACUTE LYMPHOBLASTIC LEUKEMIAWITH HIP PAIN SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Clark, Paul; Wroblewski, Tanya] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2011 VL 26 SU 1 BP S456 EP S457 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V30JQ UT WOS:000208812703017 ER PT J AU George, S Becher, D Zapor, M Hartzell, J AF George, Susan Becher, Dorothy Zapor, Michael Hartzell, Joshua TI SMOKING HABITS AND CESSATION EFFORTS AMONG DEPLOYED SOLDIERS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [George, Susan; Becher, Dorothy; Zapor, Michael; Hartzell, Joshua] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2011 VL 26 SU 1 BP S232 EP S232 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V30JQ UT WOS:000208812701194 ER PT J AU George, S Jackson, J Hanson, J AF George, Susan Jackson, Jeffrey Hanson, Janice TI BARRIERS PERCEIVED BY PHYSICIANS REGARDING THEIR OWN HEALTH CARE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [George, Susan] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jackson, Jeffrey] Clement J Zablocki VA Med Ctr, Milwaukee, WI USA. [Hanson, Janice] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2011 VL 26 SU 1 BP S98 EP S98 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V30JQ UT WOS:000208812700173 ER PT J AU Roesel, TR Feliciano, M Stano, NL Friedman, K Hunter, L Brian, C Novy, P AF Roesel, Thomas R. Feliciano, Molly Stano, Nancy L. Friedman, Karen Hunter, Leslie Brian, Crowley Novy, Pamela TI PHARMACEUTICAL FORMULATION FOR FATIGUE AND FORGETFULNESS IN POST TRAUMATIC STRESS DISORDER SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Roesel, Thomas R.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. [Feliciano, Molly; Stano, Nancy L.; Friedman, Karen; Hunter, Leslie; Brian, Crowley; Novy, Pamela] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2011 VL 26 SU 1 BP S438 EP S438 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V30JQ UT WOS:000208812702303 ER PT J AU Gupta, N Voloshinov, VB Knyazev, GA Kulakova, LA AF Gupta, Neelam Voloshinov, Vitaly B. Knyazev, Gregory A. Kulakova, Lyudmila A. TI Optical transmission of single crystal tellurium for application in acousto-optic cells SO JOURNAL OF OPTICS LA English DT Article DE single crystal tellurium; Te; refractive indices; optical absorption; optical transmission; infrared; acousto-optics; AO; AO imaging filter; AO deflector ID 10.6 MU-M; TUNABLE FILTER; PERFORMANCE; HG2CL2 AB The optical properties of single crystals of tellurium (Te) are investigated in order to develop acousto-optic (AO) devices operating in the longwave infrared spectral region. The optical transparency of carefully cut and polished plates and large size samples of Te crystals was measured from 4 to 24 mu m. The absorption of ordinary and extraordinary polarized optical beams was measured along various directions in the crystal with respect to the optic axis. Using a 10.6 mu m CO(2) laser the absorption coefficient for the best samples of Te was found to be 0.07 cm(-1) for the ordinary and between 0.07 and 4.0 cm(-1) for the extraordinary polarized optical beam. Here, we also discuss the possible application of Te crystals in fabricating AO imaging filters. C1 [Gupta, Neelam] USA, Res Lab, Adelphi, MD 20783 USA. [Voloshinov, Vitaly B.; Knyazev, Gregory A.] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. [Kulakova, Lyudmila A.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM neelam.gupta@us.army.mil; volosh@phys.msu.ru; L.Kulakova@mail.ioffe.ru RI Voloshinov, Vitaly/I-6045-2012; Gupta, Neelam/B-8702-2013 FU Civilian Research and Development Fund [RUP1-1663-MO-06]; Russian Foundation for Basic Research [RFBR 10-07-00623, 10-07-683] FX Part of this research was supported by the Civilian Research and Development Fund (Grant RUP1-1663-MO-06) and the Russian Foundation for Basic Research (Grants RFBR 10-07-00623 and 10-07-683). NR 28 TC 9 Z9 9 U1 0 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 J9 J OPTICS-UK JI J. Opt. PD MAY PY 2011 VL 13 IS 5 AR 055702 DI 10.1088/2040-8978/13/5/055702 PG 8 WC Optics SC Optics GA 784VA UT WOS:000292185100027 ER PT J AU Eustis, HL Lopez, HP Roy, TC AF Eustis, Heather L. Lopez, Heather P. Roy, Tanja C. TI Prior Low- Back Pain is Predictive of Increased Prevalence of Current Low- Back Pain Among Active Duty US Army Personnel SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Eustis, Heather L.; Roy, Tanja C.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Lopez, Heather P.] MEDDAC, Ft Campbell, KY USA. EM heather.l.eustis.ctr@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 833 BP 97 EP 97 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500256 ER PT J AU Bedno, SA Loringer, KA Kao, TC Hauret, K AF Bedno, Sheryl A. Loringer, Kelly A. Kao, Tzu-Cheg Hauret, Keith TI Causes of and Consequences from Sports-Related Injuries: A Survey of Active Duty Service Members SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Loringer, Kelly A.; Hauret, Keith] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM sheryl.ann.bedno@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 834 BP 98 EP 98 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500257 ER PT J AU Kocay, S Nindl, BC Vaara, J Kyrolainen, H AF Kocay, Sheila Nindl, Bradley C. Vaara, Jani Kyrolainen, Heikki TI Relationship of Endogenous Steroid Hormones and SHBG to Body Composition, Cardiovascular Health and Physical Fitness SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kocay, Sheila; Kyrolainen, Heikki] Univ Jyvaskyla, Jyvaskyla, Finland. [Nindl, Bradley C.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Vaara, Jani] Natl Def Univ, Helsinki, Finland. EM skocay@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 851 BP 103 EP 104 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500272 ER PT J AU Susmarski, AJ Franco, TD AF Susmarski, Adam J. Franco, Todd D. TI Baseball Player Steals Home with Left Knee Platelet Rich Plasma and Autologous Stem Cell Injections SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Susmarski, Adam J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Franco, Todd D.] Med Rehabil Inc, Pittsburgh, PA USA. EM adam.susmarski@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1125 BP 195 EP 196 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500493 ER PT J AU Kane, SF Taylor, JC Lynch, JH Cooper, PB AF Kane, Shawn F. Taylor, Jonathan C. Lynch, James H. Cooper, Patrick B. TI Head, Neck And Spine - Progressive Low Back Pain In a Soldier SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kane, Shawn F.; Taylor, Jonathan C.; Lynch, James H.] Womack Army Med Ctr, Ft Bragg, NC USA. [Cooper, Patrick B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM shawn.kane@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1152 BP 204 EP 205 PG 2 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500511 ER PT J AU Kenny, C Chen, YT De Luigi, A AF Kenny, Christopher Chen, Yin-Ting De Luigi, Arthur TI Hip Injury - Soccer SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kenny, Christopher; Chen, Yin-Ting; De Luigi, Arthur] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1193 BP 218 EP 219 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500537 ER PT J AU McCallin, JP DeLuigi, AJ AF McCallin, John P. DeLuigi, Arthur J. TI Hip Pain or Injury - Soccer SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [McCallin, John P.; DeLuigi, Arthur J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM jp.mccallin@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1192 BP 218 EP 218 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079500536 ER PT J AU Williamson, ML Ryan, EJ Fickes, EJ Kim, CH Gunstad, J Kamimori, GH Glickman, EL AF Williamson, Megan L. Ryan, Edward J. Fickes, Emily J. Kim, Chul H. Gunstad, John Kamimori, Gary H. Glickman, Ellen L. TI Caffeine, Exercise, And Selective Attention SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Williamson, Megan L.; Ryan, Edward J.; Fickes, Emily J.; Kim, Chul H.; Gunstad, John; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM mwilli93@kent.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1301 BP 256 EP 256 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501058 ER PT J AU Shultz, SJ Wideman, L Montgomery, MM Beasley, KN Nindl, BC AF Shultz, Sandra J. Wideman, Laurie Montgomery, Melissa M. Beasley, Kathleen N. Nindl, Bradley C. TI Changes in Serum Collagen Markers and IGF-I and Knee Joint Laxity Across the Menstrual Cycle SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Shultz, Sandra J.; Wideman, Laurie; Montgomery, Melissa M.] UNC Greensboro, Greensboro, NC USA. [Beasley, Kathleen N.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. EM sjshultz@uncg.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1317 BP 261 EP 261 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501074 ER PT J AU Crowder, TA AF Crowder, Todd A. TI Aerobic Capacity Influence on Load Carriage Performance and High Intensity Activity Recovery SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. EM todd.crowder@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1608 BP 366 EP 366 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501364 ER PT J AU Graham, BS Knapik, JJ Colliver, K Grier, T Steelman, R Jones, B AF Graham, Bria S. Knapik, Joseph J. Colliver, Keith Grier, Tyson Steelman, Ryan Jones, Bruce TI Comparison of Injury Incidence in Two Different Military Parachuting Systems During United States Army Airborne Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Graham, Bria S.; Knapik, Joseph J.; Grier, Tyson; Steelman, Ryan; Jones, Bruce] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Colliver, Keith] Engility Corp, Ft Belvior, VA USA. EM bria.graham@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1612 BP 367 EP 368 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501368 ER PT J AU Grier, T Swedler, D Jones, BH AF Grier, Tyson Swedler, David Jones, Bruce H. TI Effect of Body Mass Index and Aerobic Fitness on Injury Risks in US Army Trainees SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Grier, Tyson; Swedler, David; Jones, Bruce H.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. EM Tyson.Grier@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1610 BP 367 EP 367 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501366 ER PT J AU Loringer, KA Bedno, SA Kao, TC Hauret, K AF Loringer, Kelly A. Bedno, Sheryl A. Kao, Tzu-Cheg Hauret, Keith TI Incidence of Sports Injuries in the Military: 2008 Survey of Active Duty Military Members SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Loringer, Kelly A.; Hauret, Keith] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM kelly.loringer@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1611 BP 367 EP 367 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501367 ER PT J AU Roy, TC Seay, J AF Roy, Tanja C. Seay, Joseph TI Low Back Pain Prevalence and Mechanisms of Injury in an Infantry Brigade Serving in Afghanistan SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Roy, Tanja C.; Seay, Joseph] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1613 BP 368 EP 368 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501369 ER PT J AU Hendrickson, NR Sharp, MA Staab, JS McClung, HL Michniak-Kohn, BB Adam, GE Nindl, BC AF Hendrickson, Nathan R. Sharp, Marilyn A. Staab, Jeffery S. McClung, Holly L. Michniak-Kohn, Bozena B. Adam, Gina E. Nindl, Bradley C. TI Quercetin's Influence On Muscle Soreness, Markers Of Inflammation, And Muscle Damage SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Hendrickson, Nathan R.; Sharp, Marilyn A.; Staab, Jeffery S.; McClung, Holly L.; Adam, Gina E.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. [Michniak-Kohn, Bozena B.] Rutgers State Univ, Piscataway, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1779 BP 428 EP 429 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501534 ER PT J AU Sharp, MA Hendrickson, NR Staab, JS McClung, HL Michniak-Kohn, B Catrambone, DE Adam, GE Nindl, BC AF Sharp, Marilyn A. Hendrickson, Nathan R. Staab, Jeffery S. McClung, Holly L. Michniak-Kohn, Bozena Catrambone, Daniel E. Adam, Gina E. Nindl, Bradley C. TI Quercetin Did Not Influence Exercise Performance or Plasma Metabolic Markers in Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Sharp, Marilyn A.; Hendrickson, Nathan R.; Staab, Jeffery S.; McClung, Holly L.; Catrambone, Daniel E.; Adam, Gina E.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. [Michniak-Kohn, Bozena] Rutgers State Univ, New Brunswick, NJ 08903 USA. EM marilyn.sharp@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1780 BP 429 EP 429 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501535 ER PT J AU Sauer, S Ely, B Kenefick, R Seay, J Cheuvront, S AF Sauer, Shane Ely, Brett Kenefick, Robert Seay, Joseph Cheuvront, Samuel TI Effects Of Dehydration On Measures Of Quiet Standing Balance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Sauer, Shane; Ely, Brett; Kenefick, Robert; Seay, Joseph; Cheuvront, Samuel] US Army Res Inst Environm Med, Natick, MA USA. EM shane.sauer@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2048 BP 525 EP 525 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079502160 ER PT J AU Fickes, EJ Ryan, EJ Kim, CH Williamson, ML Gunstad, J Barkley, JE Kamimori, GH Glickman, EL AF Fickes, Emily J. Ryan, Edward J. Kim, Chul-Ho Williamson, Megan L. Gunstad, John Barkley, Jacob E. Kamimori, Gary H. Glickman, Ellen L. TI Perceptual Responses to Cycling Following Caffeine Administration in Chewing Gum SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Fickes, Emily J.; Ryan, Edward J.; Kim, Chul-Ho; Williamson, Megan L.; Gunstad, John; Barkley, Jacob E.; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2073 BP 534 EP 535 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079502185 ER PT J AU Gregory, RW Bond, BM AF Gregory, Robert W. Bond, Bryan M. TI Biomechanics of Movement-Related Effort: Effects of Task SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Gregory, Robert W.] US Mil Acad, West Point, NY 10996 USA. [Bond, Bryan M.] Univ Kansas, Lawrence, KS 66045 USA. EM robert.gregory@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2292 BP 612 EP 613 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079502404 ER PT J AU Linberg, AA Sweet, AF Andrews, AM AF Linberg, Alison A. Sweet, Allison F. Andrews, Anne M. TI Oxygen Consumption Of Individuals With And Without Lower Extremity Amputations During Self-selected Pace Running SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Linberg, Alison A.; Andrews, Anne M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Sweet, Allison F.] Gen Leonard Wood Army Community Hosptial, Ft Leonard Wood, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2486 BP 678 EP 678 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079502587 ER PT J AU Seay, JF Frykman, PN Gutekunst, DJ AF Seay, Joseph F. Frykman, Peter N. Gutekunst, David J. TI Constrained Cadence Marching Leads to Higher Peak Tibial Accelerations SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Seay, Joseph F.; Frykman, Peter N.; Gutekunst, David J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. EM joseph.seay@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2524 BP 691 EP 692 PG 3 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079502625 ER PT J AU Kane, MM Boyev, A Brechue, WF AF Kane, Michelle M. Boyev, Artem Brechue, William F. TI Total Daily Energy Expenditure, Body Composition, and Physical Activity in West Point Cadets SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kane, Michelle M.; Boyev, Artem; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. EM bill.brechue@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2621 BP 725 EP 725 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503090 ER PT J AU Gregory, S Headley, S Germain, M Flyvbjerg, A Frystyk, J Coughlin, MA Milch, C Sullivan, S Nindl, B AF Gregory, Sara Headley, Samuel Germain, Michael Flyvbjerg, Allan Frystyk, Jan Coughlin, Mary Ann Milch, Charles Sullivan, Sheila Nindl, Bradley TI Physical Training Leads to Improved Fitness in CKD Despite no Change in Circulating Bioactive IGF-I SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Gregory, Sara; Headley, Samuel; Coughlin, Mary Ann; Milch, Charles; Sullivan, Sheila] Springfield Coll, Springfield, MA USA. [Germain, Michael] Western New England Renal & Transplant Associates, Springfield, MA USA. [Flyvbjerg, Allan; Frystyk, Jan] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark. [Nindl, Bradley] US Army Res Inst Environm Med, Natick, MA USA. EM sgregory@spfldcol.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2728 BP 762 EP 763 PG 2 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503197 ER PT J AU Pujol, TJ Mayhew, JL Brechue, WF Smith, AE Reneau, P Barnes, JT AF Pujol, Thomas J. Mayhew, Jerry L. Brechue, W. F. Smith, A. E. Reneau, Paul Barnes, Jeremy T. TI Effect Of Heavy Resistance Training On Low- And High-intensity Upper Body Work Capacity In College Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Pujol, Thomas J.; Barnes, Jeremy T.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. [Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Kirksville, MO USA. [Brechue, W. F.] US Mil Acad, West Point, NY 10996 USA. [Smith, A. E.] Univ Oklahoma, Norman, OK 73019 USA. [Reneau, Paul] Fairmont State Univ, Fairmont, WV USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2941 BP 837 EP 838 PG 2 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503409 ER PT J AU Mayhew, JL Brechue, WF Pujol, TJ Reneau, P Smith, AE AF Mayhew, Jerry L. Brechue, William F. Pujol, Thomas J. Reneau, Paul Smith, Abbie E. TI Comparison of Training Frequency and Mode on Upper-Body Strength Gains in College Men and Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. [Reneau, Paul] Fairmont State Unievrs, Fairmont, WV USA. [Smith, Abbie E.] Univ Oklahoma, Norman, OK 73019 USA. EM jmayhew@truman.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2951 BP 841 EP 841 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503419 ER PT J AU Scofield, DE Pierce, JR Barnes, BR Kraemer, WJ Maresh, CM Anderson, JM Zambraski, EJ Nindl, BC AF Scofield, Dennis E. Pierce, Joseph R. Barnes, Brian R. Kraemer, William J. Maresh, Carl M. Anderson, Jeffrey M. Zambraski, Edward J. Nindl, Bradley C. TI Elevated IGF-I Concentration Observed In Transdermal Fluid But Not Serum Following Acute Lower-body Plyometric Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Scofield, Dennis E.; Pierce, Joseph R.; Barnes, Brian R.; Zambraski, Edward J.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. [Kraemer, William J.; Maresh, Carl M.; Anderson, Jeffrey M.] Univ Connecticut, Storrs, CT USA. EM dennis.scofield@amedd.army.mil RI SCOFIELD, DENNIS/F-3636-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 3141 BP 906 EP 907 PG 2 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503608 ER PT J AU Lord, RG Hannah, ST Jennings, PL AF Lord, Robert G. Hannah, Sean T. Jennings, Peter L. TI A framework for understanding leadership and individual requisite complexity SO ORGANIZATIONAL PSYCHOLOGY REVIEW LA English DT Article DE leadership; organizational change; self and identity AB This paper examines the relation of individual perceptual, conscious, and self-regulatory processes to the generation of requisite complexity in formal and informal leaders. Requisite complexity is a complex adaptive systems concept that pertains to the ability of a system to adjust to the requirements of a changing environment by achieving equivalent levels of complexity. We maintain that requisite complexity has both static and dynamic aspects that involve four domains (general, social, self, and affective complexity), with each being more or less important for leaders depending upon the task requirements they face. Dynamic complexity draws on these static components and also creates new aspects of complexity through the interaction of mental processes. The implications of these issues for understanding leader adaptation and development are also discussed. C1 [Lord, Robert G.] Univ Akron, Psychol, Akron, OH 44325 USA. [Hannah, Sean T.] US Mil Acad, West Point, West Point, NY USA. [Jennings, Peter L.] Arizona State Univ, WP Carey Sch Business, Tempe, AZ 85287 USA. [Jennings, Peter L.] US Army Reserve, Ft Bragg, NC USA. RP Lord, RG (reprint author), Univ Akron, Dept Psychol, Akron, OH 44325 USA. EM rlord@uakron.edu NR 83 TC 25 Z9 25 U1 3 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 2041-3866 EI 2041-3874 J9 ORGAN PSYCHOL REV JI Organ. Psychol. Rev. PD MAY PY 2011 VL 1 IS 2 BP 104 EP 127 DI 10.1177/2041386610384757 PG 24 WC Psychology, Applied; Management SC Psychology; Business & Economics GA V38ZV UT WOS:000209382200002 ER PT J AU Dewey, WS Richard, RL Parry, IS AF Dewey, William S. Richard, Reg L. Parry, Ingrid S. TI Positioning, Splinting, and Contracture Management SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA LA English DT Article DE Splinting; Positioning; Contracture; Burn; Scar ID BURN REHABILITATION; SCAR; INJURY; SKIN; PREVENTION; EXPERIENCE; EXTREMITY; TENSION; STRESS; JOINTS AB Whether a patient with burn injury is an adult or child, contracture management should be the primary focus of burn rehabilitation throughout the continuum of care. Positioning and splinting are crucial components of a comprehensive burn rehabilitation program that emphasizes contracture prevention. The emphasis of these devices throughout the phases of rehabilitation fluctuates to meet the changing needs of patients with burn injury. Early, effective, and consistent use of positioning devices and splints is recommended for successful management of burn scar contracture. C1 [Dewey, William S.; Richard, Reg L.] USA, Inst Surg Res, Burn Ctr, Rehabil Dept, Ft Sam Houston, TX 78234 USA. [Parry, Ingrid S.] Shriners Hosp Children No Calif, Sacramento, CA 95817 USA. RP Dewey, WS (reprint author), USA, Inst Surg Res, Burn Ctr, Rehabil Dept, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM scott.dewey@amedd.army.mil NR 75 TC 9 Z9 10 U1 1 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1047-9651 J9 PHYS MED REH CLIN N JI Phys. Med. Rehabil. Clin. N. Am. PD MAY PY 2011 VL 22 IS 2 BP 229 EP + DI 10.1016/j.pmr.2011.02.001 PG 20 WC Rehabilitation SC Rehabilitation GA 782KG UT WOS:000292006700005 PM 21624718 ER PT J AU Fergason, JR Blanck, R AF Fergason, John R. Blanck, Ryan TI Prosthetic Management of the Burn Amputation SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA LA English DT Article DE Amputation; Microprocessor; Transradial; Transhumeral; Shear ID TRANS-TIBIAL AMPUTATION; TRANSFEMORAL AMPUTEES; INJURY; WALKING; CLASSIFICATION; PREFERENCE; SALVAGE; LEVEL; FOOT; SKIN AB Amputations as a result of thermal or electrical burns present a unique challenge that requires a coordinated effort by the rehabilitation team. Complications of surface and deep tissue injury require adjustment to the more standard approaches to prosthetic provision. Accommodations for the complications of joint contracture, skin adhesions, sensation compromise, skin grafts, and muscle flaps must be made by the treating clinicians. Differences in the treatment timelines, socket designs, material options, and component choices are discussed to familiarize the team for optimization of function in this difficult treatment scenario. C1 [Fergason, John R.; Blanck, Ryan] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. RP Fergason, JR (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM john.fergason@amedd.army.mil NR 36 TC 1 Z9 1 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1047-9651 J9 PHYS MED REH CLIN N JI Phys. Med. Rehabil. Clin. N. Am. PD MAY PY 2011 VL 22 IS 2 BP 277 EP + DI 10.1016/j.pmr.2011.03.001 PG 24 WC Rehabilitation SC Rehabilitation GA 782KG UT WOS:000292006700008 PM 21624721 ER PT J AU Mesngon, M McNutt, P AF Mesngon, Mariano McNutt, Patrick TI Alpha-Latrotoxin Rescues SNAP-25 from BoNT/A-Mediated Proteolysis in Embryonic Stem Cell-Derived Neurons SO TOXINS LA English DT Article DE botulinum neurotoxin; alpha-latrotoxin; embryonic stem cell-derived neurons ID WIDOW SPIDER VENOM; BOTULINUM-NEUROTOXIN-A; FROG NEUROMUSCULAR-JUNCTIONS; TRANSMITTER RELEASE; NERVE-TERMINALS; INTENSE RELEASE; FREEZE-FRACTURE; MEMBRANE PORES; EXOCYTOSIS; RECOVERY AB The botulinum neurotoxins (BoNTs) exhibit zinc-dependent proteolytic activity against members of the core synaptic membrane fusion complex, preventing neurotransmitter release and resulting in neuromuscular paralysis. No pharmacologic therapies have been identified that clinically relieve botulinum poisoning. The black widow spider venom alpha-latrotoxin (LTX) has the potential to attenuate the severity or duration of BoNT-induced paralysis in neurons via the induction of synaptic degeneration and remodeling. The potential for LTX to antagonize botulinum poisoning was evaluated in embryonic stem cell-derived neurons (ESNs), using a novel screening assay designed around the kinetics of BoNT/A activation. Exposure of ESNs to 400 pM LTX for 6.5 or 13 min resulted in the nearly complete restoration of uncleaved SNAP-25 within 48 h, whereas treatment with 60 mM K+ had no effect. Time-lapse imaging demonstrated that LTX treatment caused a profound increase in Ca2+ influx and evidence of excitotoxicity, though ESNs remained viable 48 h after LTX treatment. This is the first instance of a cell-based treatment that has shown the ability to eliminate BoNT activity. These data suggest that LTX treatment may provide the basis for a new class of therapeutic approach to BoNT intoxication and may contribute to an improved understanding of long-term mechanisms of BoNT intoxication and recovery. They further demonstrate that ESNs are a novel, responsive and biologically relevant model for LTX research and BoNT therapeutic drug discovery. C1 [Mesngon, Mariano; McNutt, Patrick] USA, Med Res Inst Chem Def, Gunpowder, MD 21010 USA. RP Mesngon, M (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Gunpowder, MD 21010 USA. EM mariano.mesngon@us.army.mil; patrick.mcnutt@us.army.mil OI McNutt, Patrick/0000-0002-5703-4565 FU Defense Threat Reduction Agency; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [3.10037_07_RC_B, CBM.THRTOX.01.10.RC.021] FX We greatly appreciate the advice and support of Mike Adler and Megan Lyman (USAMRICD, MD); and Joe Larson and Erin Reichert for encouragement and financial support (the Defense Threat Reduction Agency). This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division [grant numbers 3.10037_07_RC_B and CBM.THRTOX.01.10.RC.021]. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 46 TC 10 Z9 11 U1 0 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD MAY PY 2011 VL 3 IS 5 BP 489 EP 503 DI 10.3390/toxins3050489 PG 15 WC Toxicology SC Toxicology GA 995AE UT WOS:000307977000005 PM 22069721 ER PT J AU Killgore, KJ Miranda, LE Murphy, CE Wolff, DM Hoover, JJ Keevin, TM Maynord, ST Cornish, MA AF Killgore, K. Jack Miranda, L. E. Murphy, Catherine E. Wolff, Douglas M. Hoover, Jan Jeffrey Keevin, Thomas M. Maynord, Steven T. Cornish, Mark A. TI Fish Entrainment Rates through Towboat Propellers in the Upper Mississippi and Illinois Rivers SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID MAIN CHANNEL; NAVIGATION; ABUNDANCE; MORTALITY; SYSTEM; LIFE AB A specially designed net was used to study fish entrainment and injury through towboat propellers in 13 pools of the Upper Mississippi and Illinois rivers. The net was attached to the stern of a 48.8-m-long towboat with twin propellers (in Kort propulsion nozzles), and sampling typically took place while the towboat pushed 15 loaded barges upstream at a time. In total, 254 entrainment samples over 894 km of the 13 study pools were collected. The sampling efforts produced 16,005 fish representing 15 families and at least 44 species; fish ranged in total length from 3 to 123 cm, but only 12.5-cm or longer fish were analyzed because smaller fish could escape through the mesh of the trawl. Clupeidae (68% of total catch) and Sciaenidae (21%) were the dominant families. We detected no effects of towboat operation variables (speed and engine [i.e., propeller] revolutions per minute [RPM]) on entrainment rate (i.e., fish/km), but entrainment rate showed a wedge-shaped distribution relative to hydraulic and geomorphic characteristics of the channel. Entrainment rate was low (< 1 fish/km) in wide sections of the river, deep water, and swift current (or time periods characterized by faster flow); however, entrainment in narrow sections with shallow, slow water was highly variable and occasionally reached high levels (> 30 fish/km). Although total entrainment rate was not related to engine RPM, the probability of being struck by a propeller increased with fish length and engine RPM. Limits on engine RPM in narrow, shallow, and sluggish reaches could reduce entrainment impact, particularly for large-bodied fish. C1 [Killgore, K. Jack; Hoover, Jan Jeffrey; Maynord, Steven T.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA. [Murphy, Catherine E.] Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [Wolff, Douglas M.] Elliott Bay Design Grp, Seattle, WA 98107 USA. [Keevin, Thomas M.] USA, Corps Engineers, St Louis, MO 63103 USA. [Cornish, Mark A.] USA, Corps Engineers, Rock Isl, IL 61299 USA. RP Killgore, KJ (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jack.killgore@usace.army.mil FU U.S. Army Corps of Engineers Rock Island District FX Steven George, Bradley Lewis, Bill Lancaster, and Jay Collins (Engineer Research and Development Center) assisted in all phases of the field study. Wendy Taylor (National Oceanic and Atmospheric Administration, Pascagoula, Mississippi) designed and constructed the net with assistance from John Watson and Jack Forrester (National Oceanic and Atmospheric Administration). Steve Parrish (S&S Trawl Shop) provided valuable modifications to the net. Port Captain Raymond Hopkins (Archer Daniels Midland Corporation [ADM]) provided logistical assistance and was extremely helpful in scheduling the availability of the MV American Beauty. Captain Rennie Kienitz (ADM) provided invaluable support and expertise in setting up and conducting the study. Chief Engineer Donnie Collins (ADM) developed modifications to the trawling gantry that substantially improved trawling efficiency and safety. Other ADM personnel who provided important assistance on the MV American Beauty included Hank Magnus, Tom Jacobsen, Leroy Foley, Jacob Sowers, and Wes Tutor. The U.S. Army Corps of Engineers Rock Island District funded this study. The contents of this report are not to be used for advertising, publication, or promotional purposes. Reference to trade names does not imply endorsement by the U.S. Government. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. Permission to publish this document was granted by the Chief of Engineers. NR 28 TC 7 Z9 7 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD MAY PY 2011 VL 140 IS 3 BP 570 EP 581 DI 10.1080/00028487.2011.581977 PG 12 WC Fisheries SC Fisheries GA 779WV UT WOS:000291813800005 ER PT J AU Abbott, KC Yuan, CM Lee, JL AF Abbott, Kevin C. Yuan, Christina M. Lee, Jessica L. TI Nothing to Sneeze At: Efficacy and Cost-Effectiveness of the Influenza Vaccine in Patients Receiving Long-term Dialysis SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Editorial Material ID STAGE RENAL-DISEASE; ANTIBODY-RESPONSE; HEMODIALYSIS; MORTALITY C1 [Abbott, Kevin C.] Walter Reed Army Med Ctr, Dept Nephrol, Washington, DC 20307 USA. [Lee, Jessica L.] Natl Naval Med Ctr, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Kevin.Abbott@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 14 TC 1 Z9 1 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAY PY 2011 VL 57 IS 5 BP 651 EP 653 DI 10.1053/j.ajkd.2011.02.380 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 749ZW UT WOS:000289513600004 PM 21496725 ER PT J AU Iyengar, SG Varshney, PK Damarla, T AF Iyengar, Satish G. Varshney, Pramod K. Damarla, Thyagaraju TI A Parametric Copula-Based Framework for Hypothesis Testing Using Heterogeneous Data SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Copula theory; hypothesis testing; Kullback-Leibler divergence; multibiometrics; multimodal signals; multisensor fusion; statistical dependence ID OBJECT TRACKING; FUSION; MODEL AB We present a parametric framework for the joint processing of heterogeneous data, specifically for a binary classification problem. Processing such a data set is not straightforward as heterogeneous data may not be commensurate. In addition, the signals may also exhibit statistical dependence due to overlapping fields of view. We propose a copula-based solution to incorporate statistical dependence between disparate sources of information. The important problem of identifying the best copula for binary classification problems is also addressed. Computer simulation results are presented to demonstrate the feasibility of our approach. The method is also tested on real-data provided by the National Institute of Standards and Technology (NIST) for a multibiometric face recognition application. Finally, performance limits are derived to study the influence of statistical dependence on classification performance. C1 [Iyengar, Satish G.; Varshney, Pramod K.] Syracuse Univ, Dept Elect Engn & Comp Sci, Syracuse, NY 13244 USA. [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Iyengar, SG (reprint author), Syracuse Univ, Dept Elect Engn & Comp Sci, Syracuse, NY 13244 USA. EM siyengarvarshney@syr.edu; rdamarla@arl.army.mil FU Army Research Laboratory [W911NF-07-2-0007]; ARO [W911NF-09-1-0244] FX Manuscript received May 19, 2010; revised September 18, 2010, December 20, 2010; accepted December 21, 2010. Date of publication February 14, 2011; date of current version April 13, 2011. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Aleksandar Dogandzic. This work was supported by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-07-2-0007 and ARO grant W911NF-09-1-0244. The material in this paper was presented at ICASSP 2009, Taipei, Taiwan. NR 40 TC 28 Z9 28 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY PY 2011 VL 59 IS 5 BP 2308 EP 2319 DI 10.1109/TSP.2011.2105483 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA 749NT UT WOS:000289475800031 ER PT J AU Houng, HSH Zhou, YF Lyons, A Solovyov, A Street, C Firth, C Lipkin, WI Myers, C Blair, P Kuschner, R AF Houng, Huo-Shu H. Zhou, Yanfei Lyons, Arthur Solovyov, Alexander Street, Craig Firth, Cadhla Lipkin, W. I. Myers, Chris Blair, Patrick Kuschner, Robert TI Evolutionary studies of 2009 H1N1 pandemic via next generation sequencing (NGS): circulating influenza A from the worldwide locations are the variants of original 2009 H1N1 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article; Proceedings Paper CT Conference on Options for the Control of Influenza VII CY SEP 03-07, 2010 CL Hong Kong, PEOPLES R CHINA DE 2009 H1N1; evolution; next generation sequencing ID VIRUS; TRANSMISSION; CULTURE AB Pandemic 2009 influenza A virus (A/H1N1/2009) continues to cause worldwide influenza outbreaks beyond its 1st anniversary. Full genomic sequence analysis of 2009 pandemic infections might provide an important role on preparation for future influenza outbreaks. We investigated the potential of ultra-deep pyrosequencing (Roche 454 FLX) to determine and assemble >100 full genome sequences of novel 2009 H1N1 viruses isolated worldwide since the beginning of the 2009 pandemic. Phylogenetic studies of the eight influenza A gene segments were generated and were found to display higher genetic diversity for HA and NA segments as compared to the mutational rates for other five RNA segments. Analysis of full influenza genomes containing all 8 concatenated RNA segments revealed the existence of two distinctive genetic groups, Clades 1 and 2. It was concluded that 2009 H1N1 influenza A currently causing large scale global infections all belong to the genetic Clade 2. The initial 2009 H1N1 isolates of Mexican/California origins isolated at the beginning of 2009 pandemics are probably no longer in circulation. C1 [Houng, Huo-Shu H.; Zhou, Yanfei; Lyons, Arthur; Kuschner, Robert] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Solovyov, Alexander; Street, Craig; Firth, Cadhla; Lipkin, W. I.] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [Myers, Chris; Blair, Patrick] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Houng, HSH (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013 NR 23 TC 0 Z9 0 U1 1 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2011 VL 5 SU 1 BP 398 EP 402 PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 747BV UT WOS:000289296200130 ER PT J AU Lakshmi, TSR Shanmugasundaram, N Shanmuganathan, S Babu, M AF Lakshmi, Thiagavathi S. Ramyaa Shanmugasundaram, Natesan Shanmuganathan, Seetharaman Babu, Mary TI Efficacy of desulfated heparin mitigating inflammation in rat burn wound model SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS LA English DT Article DE 2,3 DSH; inflammation; collagen; cytokines; burns ID P-SELECTIN; MACROPHAGES; REPAIR; TISSUE AB During skin repair, leukocyte infiltration is the principal inflammatory response which is instrumental in triggering growth factor and cytokine signals that orchestrate together to recruit cells necessary for healing. In severe wounds like burn, when acute inflammation becomes chronic, intervention is required to control inflammation so as to hasten the process of healing. Heparin, a known anticoagulant also possesses anti-inflammatory activity by its ability to interfere with the adhesion of leukocytes to the endothelium. Desulfated heparins (DSH) have subdued anticoagulant activity while possessing increased anti-inflammatory activity. Among which 2,3 DSH is found to have marked potency as an anti-inflammatory agent and has been utilized for this study. In this investigation, a controlled delivery system was designed by incorporating 2,3 DSH in microspheres and embedding in collagen matrix which could serve as a wound dressing in burns. In vivo evaluation of healing process was ascertained in rat burn wound model by qualitative and quantitative estimation of proinflammatory cytokines in serum and granulation tissue and collagen turnover was also assessed as healing progressed. The results of this study suggests that 2,3 DSH could be delivered in a controlled manner to regulate inflammatory events to hasten healing of burn wounds. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 97B: 215-223, 2011. C1 [Lakshmi, Thiagavathi S. Ramyaa; Shanmugasundaram, Natesan; Shanmuganathan, Seetharaman; Babu, Mary] Cent Leather Res Inst, Div Biomat, Chennai 600020, Tamil Nadu, India. [Shanmugasundaram, Natesan; Shanmuganathan, Seetharaman] USA, Regenerat Med Res Program, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Babu, M (reprint author), Cent Leather Res Inst, Div Biomat, Chennai 600020, Tamil Nadu, India. EM marybabu@hotmail.com OI Natesan, Shanmugasundaram/0000-0003-4213-3111 NR 26 TC 5 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4973 EI 1552-4981 J9 J BIOMED MATER RES B JI J. Biomed. Mater. Res. Part B PD MAY PY 2011 VL 97B IS 2 BP 215 EP 223 DI 10.1002/jbm.b.31797 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 750ZX UT WOS:000289588200002 PM 21391301 ER PT J AU Hatch, S Endy, TP Thomas, S Mathew, A Potts, J Pazoles, P Libraty, DH Gibbons, R Rothman, AL AF Hatch, Steven Endy, Tim P. Thomas, Stephen Mathew, Anuja Potts, James Pazoles, Pamela Libraty, Daniel H. Gibbons, Robert Rothman, Alan L. TI Intracellular Cytokine Production by Dengue Virus-specific T cells Correlates with Subclinical Secondary Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; THAILAND; SEROTYPES; RESPONSES; DISEASE; CHALLENGES; SEVERITY; CHILDREN; VACCINE; VIREMIA AB The pathophysiology of dengue virus infection remains poorly understood, although secondary infection is strongly associated with more severe disease. In the present study, we performed a nested, case-control study comparing the responses of pre-illness peripheral blood mononuclear cells between children who would subsequently develop either subclinical or symptomatic secondary infection 6-11 months after the baseline blood samples were obtained and frozen. We analyzed intracellular cytokine production by CD4(+) and CD8(+) cells in response to stimulation with dengue antigen. We found higher frequencies of dengue virus-specific TNF alpha, IFN gamma-, and IL-2-producing T cells among schoolchildren who subsequently developed subclinical infection, compared with those who developed symptomatic secondary dengue virus infection. Although other studies have correlated immune responses during secondary infection with severity of disease, to our knowledge this is the first study to demonstrate a pre-infection dengue-specific immune response that correlates specifically with a subclinical secondary infection. C1 [Hatch, Steven; Mathew, Anuja; Potts, James; Pazoles, Pamela; Libraty, Daniel H.; Rothman, Alan L.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Endy, Tim P.; Gibbons, Robert] SUNY Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY USA. [Thomas, Stephen] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Rothman, AL (reprint author), UMass Med Sch, Ctr Infect Dis & Vaccine Res, 55 Lake Ave N, Worcester, MA 01655 USA. EM alan.rothman@umassmed.edu FU National Institutes of Health [P01 AI034533]; United States Army Medical Research and Materiel Command; National Institutes of Health (Diabetes Endocrinology Research Center [DERC] [DK32520] FX This work was funded by the National Institutes of Health (P01 AI034533) and the United States Army Medical Research and Materiel Command, Ft Detrick MD. Core resources were supported by the National Institutes of Health (Diabetes Endocrinology Research Center [DERC] grant DK32520]. ALR is a member of the UMMS DERC. NR 28 TC 40 Z9 40 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2011 VL 203 IS 9 BP 1282 EP 1291 DI 10.1093/infdis/jir012 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 747FQ UT WOS:000289306100012 PM 21335561 ER PT J AU Berg, MJ Sorensen, CM Chakrabarti, A AF Berg, M. J. Sorensen, C. M. Chakrabarti, A. TI A new explanation of the extinction paradox SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Extinction paradox; Extinction; Ewald-Oseen; Geometrical optics; Light scattering ID OPTICAL THEOREM; CROSS-SECTIONS; DERIVATION; SCATTERING; PARTICLES AB This work presents a new explanation for the extinction paradox and shows that the canonical explanations are incorrect. This paradox refers to the large size limit of a particle's extinction cross section. It is called a paradox because the geometrical optics approximation, which should be valid in this limit, predicts a cross section that is half of the true value. The new explanation is achieved by formulating the scattered wave in terms of an integral over the particle's surface where the seemingly unrelated Ewald-Oseen theorem appears in the formulation. By expressing the cross section in terms of this surface integral, the Ewald-Oseen theorem is analytically connected to the cross section. Several illustrations are used to reveal the significance of this connection: The paradox is seen to be a consequence of the requirement that the incident wave be canceled within the particle by secondary radiation from its own internal field. Following this, the canonical explanations are examined to reveal serious problems. In the process, the same asymptotic extinction behavior is shown to occur for small highly refractive dielectric particles, and thus is not just a large particle size or small wavelength effect as is often stated. The traditional explanations cannot account for this behavior while the new one actually predicts it. All in all, this work constitutes a fundamental reworking of 60 years of accepted understanding for the cause of the asymptotic behavior of the extinction cross section. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Berg, M. J.] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Berg, M. J.] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. [Sorensen, C. M.; Chakrabarti, A.] Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA. RP Berg, MJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. EM matt.berg@msstate.edu RI Sorensen, Christopher/G-4900-2013 OI Sorensen, Christopher/0000-0002-1980-3394 NR 33 TC 10 Z9 10 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2011 VL 112 IS 7 SI SI BP 1170 EP 1181 DI 10.1016/j.jqsrt.2010.08.024 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 747PR UT WOS:000289332400006 ER PT J AU Chen, J Crispin, JC Lucca, JD Tsokos, GC AF Chen, Jie Crispin, Jose C. Lucca, Jurandir Dalle Tsokos, George C. TI A Novel Inhibitor of the Alternative Pathway of Complement Attenuates Intestinal Ischemia/Reperfusion-Induced Injury SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE ischemia/reperfusion injury; CRIg-Fc; complement; alternative pathway ID TISSUE-INJURY; MESENTERIC ISCHEMIA/REPERFUSION; NATURAL ANTIBODIES; REPERFUSION INJURY; ACTIVATION; MICE; AUTOANTIBODIES; CRIG AB Complement activation has been demonstrated to contribute significantly to the expression of IR-induced tissue damage. Each of the three complement pathways, classic, alternative, and lectin, has been implicated in the instigation of tissue pathology. In this study, we used a selective inhibitor of the alternative pathway, that is, a soluble form of complement receptor of the immunoglobulin superfamily (CRIg-Fc) to determine whether it can prevent IR tissue injury. We demonstrate that treatment of C57B1/6 mice prior to mesenteric IR prevents local (intestinal) and remote (lung) injury by limiting deposition of complement and entry of polymorphonuclear cells to the sites of injury. Our results show that CRIg-Fc represents a candidate to limit IR injury as it occurs in various clinical conditions. (C) 2011 Elsevier Inc. All rights reserved. C1 [Chen, Jie; Crispin, Jose C.; Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. [Lucca, Jurandir Dalle] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, 330 Brookline Ave,CLS-937, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu NR 22 TC 12 Z9 13 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD MAY PY 2011 VL 167 IS 2 BP E131 EP E136 DI 10.1016/j.jss.2009.05.041 PG 6 WC Surgery SC Surgery GA 748RG UT WOS:000289407800010 PM 19691988 ER PT J AU Lu, XY Li, YS Simovic, MO Peckham, R Wang, Y Tsokos, GC Lucca, JJD AF Lu, Xinyue Li, Yansong Simovic, Milomir O. Peckham, Russell Wang, Ying Tsokos, George C. Lucca, Jurandir J. Dalle TI Decay-Accelerating Factor Attenuates C-Reactive Protein-Potentiated Tissue Injury After Mesenteric Ischemia/Reperfusion SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE complement; C-reactive protein; inflammation; rodent; mesenteric ischemia ID ISCHEMIA-REPERFUSION INJURY; COMPLEMENT REGULATORY PROTEINS; INTESTINAL ISCHEMIA; IMMUNE-RESPONSE; RAT MODEL; INFLAMMATION; INHIBITION; RECEPTORS; INFECTION; CD55 AB Background. C-reactive protein (CRP) is an acute pro-inflammatory mediator that has been demonstrated to enhance ischemia/reperfusion (IR) injury by virtue of activating the complement system. CRP is able to interact with complement proteins such as C1q, complement factor H, and C4b-binding protein. Since complement activation is central in the expression of tissue injury following IR, we have investigated the effects of human decay-accelerating factor (DAF), a complement inhibitor, on CRP-potentiated complement activation and tissue injury in mice subjected to mesenteric IR. Materials and Methods. Male C57B1/6 mice were allocated into eight groups: (1) Sham-operated group without IR injury; (2) CRPD+Sham group; (3) IR group; (4) CRP+IR group; (5) DAF group; (6) CRP+DAF group; (7) IR+DAF group, and (8) CRP+IR+DAF group. Intestinal and lung injury, neutrophil infiltration, myeloperoxidase (MPO) expression, complement component deposition, and interleukin-6 (IL-6) production were assessed for each treatment group of mice. Results. We report that administration of DAF significantly attenuates the CRP-enhanced intestinal injury as well as remote lung damages following acute mesenteric IR in mice, while DAF inhibits complement activation, suppresses neutrophil infiltration, and reduces IL-6 production. Conclusions. Our study suggests that inhibition complement activation with DAF may prove useful for the treatment of post-ischemic inflammatory in-juries associated with an increased production of CRP. Published by Elsevier Inc. C1 [Lu, Xinyue; Li, Yansong; Simovic, Milomir O.; Peckham, Russell; Wang, Ying; Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. [Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA. RP Lucca, JJD (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, 503 Robert Grant Ave,Room 1A32, Silver Spring, MD 20910 USA. EM jurandir.dallelucca@us.army.mil FU Department of Defense Combat Casualty Care Research Program FX The authors acknowledge support for this work by the Department of Defense Combat Casualty Care Research Program. NR 40 TC 8 Z9 8 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD MAY PY 2011 VL 167 IS 2 BP E103 EP E115 DI 10.1016/j.jss.2009.10.021 PG 13 WC Surgery SC Surgery GA 748RG UT WOS:000289407800007 PM 20189588 ER PT J AU Geisbert, TW Bailey, M Hensley, L Asiedu, C Geisbert, J Stanley, D Honko, A Johnson, J Mulangu, S Pau, MG Custers, J Vellinga, J Hendriks, J Jahrling, P Roederer, M Goudsmit, J Koup, R Sullivan, NJ AF Geisbert, Thomas W. Bailey, Michael Hensley, Lisa Asiedu, Clement Geisbert, Joan Stanley, Daphne Honko, Anna Johnson, Joshua Mulangu, Sabue Pau, Maria Grazia Custers, Jerome Vellinga, Jort Hendriks, Jenny Jahrling, Peter Roederer, Mario Goudsmit, Jaap Koup, Richard Sullivan, Nancy J. TI Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge SO JOURNAL OF VIROLOGY LA English DT Article ID PRIME-BOOST REGIMENS; T-CELL RESPONSES; DENDRITIC CELLS; RHESUS-MONKEYS; NEUTRALIZING ANTIBODIES; PREEXISTING IMMUNITY; ANTI-AD5 IMMUNITY; HEALTHY-ADULTS; IMMUNOGENICITY; VIRUS AB The use of adenoviruses (Ad) as vaccine vectors against a variety of pathogens has demonstrated their capacity to elicit strong antibody and cell-mediated immune responses. Adenovirus serotype C vectors, such as Ad serotype 5 (Ad5), expressing Ebolavirus (EBOV) glycoprotein (GP), protect completely after a single inoculation at a dose of 10(10) viral particles. However, the clinical application of a vaccine based on Ad5 vectors may be hampered, since impairment of Ad5 vaccine efficacy has been demonstrated for humans and nonhuman primates with high levels of preexisting immunity to the vector. Ad26 and Ad35 segregate genetically from Ad5 and exhibit lower seroprevalence in humans, making them attractive vaccine vector alternatives. In the series of studies presented, we show that Ad26 and Ad35 vectors generate robust antigen-specific cell-mediated and humoral immune responses against EBOV GP and that Ad5 immune status does not affect the generation of GP-specific immune responses by these vaccines. We demonstrate partial protection against EBOV by a single-shot Ad26 vaccine and complete protection when this vaccine is boosted by Ad35 1 month later. Increases in efficacy are paralleled by substantial increases in T-and B-cell responses to EBOV GP. These results suggest that Ad26 and Ad35 vectors warrant further development as candidate vaccines for EBOV. C1 [Bailey, Michael; Asiedu, Clement; Stanley, Daphne; Mulangu, Sabue; Sullivan, Nancy J.] NIAID, Biodefense Res Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Geisbert, Thomas W.; Hensley, Lisa; Geisbert, Joan; Honko, Anna; Johnson, Joshua] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Roederer, Mario; Koup, Richard] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Jahrling, Peter] NIAID, Integrated Res Facil, NIH, Bethesda, MD 20817 USA. [Pau, Maria Grazia; Custers, Jerome; Vellinga, Jort; Hendriks, Jenny; Goudsmit, Jaap] Crucell, NL-2333 CN Leiden, Netherlands. RP Sullivan, NJ (reprint author), NIAID, Biodefense Res Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM nsullivan@nih.gov OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X NR 50 TC 61 Z9 68 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD MAY PY 2011 VL 85 IS 9 BP 4222 EP 4233 DI 10.1128/JVI.02407-10 PG 12 WC Virology SC Virology GA 751LG UT WOS:000289618600016 PM 21325402 ER PT J AU Urso, ML AF Urso, Maria L. TI Is It Time to Change the Ground Rules of Exercise-Related Genomics Research? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material ID PERFORMANCE GENOMICS; FITNESS; MAP C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. OI Urso, Maria/0000-0001-8906-4673 NR 8 TC 2 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 BP 753 EP 754 DI 10.1249/MSS.0b013e3182155d43 PG 2 WC Sport Sciences SC Sport Sciences GA 750OF UT WOS:000289557100002 PM 21499052 ER PT J AU Nindl, BC Mcclung, JP Miller, JK Karl, JP Pierce, JR Scofield, DE Young, AJ Lieberman, HR AF Nindl, Bradley C. Mcclung, James P. Miller, Jeremy K. Karl, J. Philip Pierce, Joseph R. Scofield, Dennis E. Young, Andrew J. Lieberman, Harris R. TI Bioavailable IGF-I Is Associated with Fat-Free Mass Gains after Physical Training in Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE IGF BINDING PROTEINS; FAT-FREE MASS; EXERCISE; ROC CURVE; MILITARY ID GROWTH-FACTOR-I; REGIONAL BODY-COMPOSITION; BINDING-PROTEINS; IRON STATUS; MEN; FITNESS; BIOACTIVITY; EXERCISE; MUSCLE; YOUNG AB NINDL, B. C., J. P. MCCLUNG, J. K. MILLER, J. P. KARL, J. R. PIERCE, D. E. SCOFIELD, A. J. YOUNG, and H. R. LIEBERMAN Bioavailable IGF-I Is Associated with Fat-Free Mass Gains after Physical Training in Women. Med. Sci. Sports Exerc., Vol. 43, No. 5, pp. 793-799, 2011. The contributions of systemic versus local insulin-like growth factor-I (IGF-I) action for mediating fat-free mass (FFM) accretion have yet to be fully clarified, but circulating IGF-I is the preferred measure in clinical practice, and its merits as a biomarker have been demonstrated for a number of physiological outcomes. Purpose: To test the hypothesis that bioavailable IGF-I would have a stronger association with physical activity-induced FFM accretion than total IGF-I and would serve as a prognostic indicator of FFM accretion. Methods: Seventy-seven young healthy women (21 +/- 5 yr, 62.7 +/- 8.5 kg, 27.0% +/- 6.0% body fat) participated in 8 wk of Army basic training involving intense physical activity. Total and bioavailable IGF-I; IGF binding proteins (IGFBP) 1, 2, 3, 4, 5, and 6; and body composition parameters were measured before and after the training. Results: There were significant (P <= 0.05) increases in FFM (6%) and decreases in fat mass (-13%). Total IGF-I and IGFBP-4 to -6 increased, whereas IGFBP-1 and IGFBP-2 decreased. Bioavailable IGF-I (24%) explained three times the amount of variance in relative FFM changes than did total IGF-I (8%). Receiver operator characteristic curve analysis revealed that women with lower baseline bioavailable IGF-I were twice as likely to experience FFM gains > 7%. Women gaining > 7% FFM had greater increases in total IGF-I, maintained bioavailable IGF-I concentrations and experienced greater decreases in IGFBP-2 and increases in IGFBP-6 than those women gaining < 7% FFM. Conclusions: Circulating bioavailable IGF-I has a moderate association with physical activity-induced increases in FFM accretion in young, healthy women, and this association is greater than observed for total IGF-I. C1 [Nindl, Bradley C.; Miller, Jeremy K.; Pierce, Joseph R.; Scofield, Dennis E.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Mcclung, James P.; Karl, J. Philip; Young, Andrew J.; Lieberman, Harris R.] USA, Div Nutr, Environm Med Res Inst, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM Bradley.nindl@us.army.mil RI McClung, James/A-1989-2009; SCOFIELD, DENNIS/F-3636-2015; OI Karl, J. Philip/0000-0002-5871-2241 FU U.S. Army Medical Research and Materiel Command FX This study was supported by the U.S. Army Medical Research and Materiel Command. The results of the present study do not constitute endorsement by the American College of Sports Medicine. NR 34 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 BP 793 EP 799 DI 10.1249/MSS.0b013e31820065ea PG 7 WC Sport Sciences SC Sport Sciences GA 750OF UT WOS:000289557100008 PM 20962685 ER PT J AU Hughes, LM Lanteri, CA O'Neil, MT Johnson, JD Gribble, GW Trumpower, BL AF Hughes, Louise M. Lanteri, Charlotte A. O'Neil, Michael T. Johnson, Jacob D. Gribble, Gordon W. Trumpower, Bernard L. TI Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE Malaria; Plasmodium; Pneumocystis; Toxoplasma; Atovaquone; Hydroxy-naphthoquinones; Cytochrome bc(1) complex ID CYTOCHROME BC(1) COMPLEX; MITOCHONDRIAL ELECTRON-TRANSPORT; IRON-SULFUR PROTEIN; SACCHAROMYCES-CEREVISIAE; ATOVAQUONE-RESISTANCE; MOLECULAR-BASIS; B MUTATIONS; PLASMODIUM-FALCIPARUM; UBIQUINOL OXIDATION; TOXOPLASMA-GONDII AB Atovaquone is a hydroxy-naphthoquinone that is used to treat parasitic and fungal infections including Plasmodium falciparum (malaria), Pneumocystis jivorecii (pneumonia) and Toxoplasma gondii (toxoplasmosis). It blocks mitochondrial oxidation of ubiquinol in these organisms by binding to the ubiquinol oxidation site of the cytochrome bc(1) complex. Failure of atovaquone treatment has been linked to the appearance of mutations in the mitochondrially encoded gene for cytochrome b. In order to determine the optimal parameters required for inhibition of respiration in parasites and pathogenic fungi and overcome drug resistance, we have synthesized and tested the inhibitory activity of novel hydroxy-naphthoquinones against blood stage P. falciparum and liver stage P. berghei and against cytochrome bc(1) complexes isolated from yeast strains bearing mutations in cytochrome b associated with resistance in Plasmodium, Pneumocystis, and Toxoplasma. One of the new inhibitors is highly effective against an atovaquone resistant Plasmodium and illustrates the type of modification to the hydroxy-naphthoquinone ring of atovaquone that might mitigate drug resistance. (C) 2011 Elsevier B.V. All rights reserved. C1 [Hughes, Louise M.; Trumpower, Bernard L.] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA. [Lanteri, Charlotte A.; O'Neil, Michael T.; Johnson, Jacob D.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Gribble, Gordon W.] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA. RP Trumpower, BL (reprint author), Dartmouth Med Sch, Dept Biochem, 7200 Vail, Hanover, NH 03755 USA. EM Trumpower@Dartmouth.edu FU NIH [GM 20379] FX Supported by NIH Grant GM 20379. We thank Dr. Raul Covian for analysis of the inhibitor titration data. We are also grateful to the following individuals for conducting in vitro assays at the Walter Reed Army Institute of Research: Lucia Gerena and Norma Roncal executed the P. falciparum inhibitor susceptibility assay: Erin Harris conducted the inhibition of P. berghei liver stage development assay; and Dr. Diana Caridha performed the MTT hepatocyte cytotoxicity assay. NR 36 TC 19 Z9 20 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 EI 1872-9428 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD MAY PY 2011 VL 177 IS 1 BP 12 EP 19 DI 10.1016/j.molbiopara.2011.01.002 PG 8 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 747RV UT WOS:000289338000002 PM 21251932 ER PT J AU Awandare, GA Spadafora, C Moch, JK Dutta, S Haynes, JD Stoute, JA AF Awandare, Gordon A. Spadafora, Carmenza Moch, J. Kathleen Dutta, Sheetij Haynes, J. David Stoute, Jose A. TI Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE Malaria; CR1; Red Cell; Invasion; Sialic acid AB A majority of Plasmodium falciparum strains invade erythrocytes through interactions with sialic acid (SA) on glycophorins. However, we recently reported that complement receptor 1 (CR1) is a SA-independent invasion receptor of many laboratory strains of P. falciparum. To determine the role of CR1 in erythrocyte invasion among P. falciparum field isolates, we tested eight isolates obtained from children in Kenya. All the parasites examined were capable of invading in a SA-independent manner, and invasion of neuraminidase-treated erythrocytes was nearly completely blocked by anti-CR1 and soluble CR1 (sCR1). In addition, anti-CR1 and sCR1 partially inhibited invasion of intact erythrocytes in a majority of isolates tested. Sequencing of the hypervariable region of P. falciparum AMA-1 showed considerable diversity among all the isolates. These data demonstrate that CR1 mediates SA-independent erythrocyte invasion in P. falciparum field isolates. (C) 2011 Elsevier B.V. All rights reserved. C1 [Stoute, Jose A.] Penn State Univ, Dept Med, Coll Med, Div Infect Dis, Hershey, PA 17033 USA. [Awandare, Gordon A.; Moch, J. Kathleen; Dutta, Sheetij; Haynes, J. David; Stoute, Jose A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Awandare, Gordon A.] Univ Ghana, Dept Biochem Cell & Mol Biol, Legon, Accra, Ghana. [Spadafora, Carmenza] Inst Invest Cient & Serv Alta Tecnol AIP INDICASA, Ciudad Del Saber, Clayton, Panama. RP Stoute, JA (reprint author), Penn State Univ, Dept Med, Coll Med, Div Infect Dis, 500 Univ Dr, Hershey, PA 17033 USA. EM jstoute@psu.edu OI Spadafora, Carmenza/0000-0002-3002-9467; Awandare, Gordon/0000-0002-8793-3641 FU NHLBI NIH HHS [R01 HL071502, R01 HL071502-04, HL 71502] NR 20 TC 15 Z9 15 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 EI 1872-9428 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD MAY PY 2011 VL 177 IS 1 BP 57 EP 60 DI 10.1016/j.molbiopara.2011.01.005 PG 4 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 747RV UT WOS:000289338000008 PM 21251929 ER PT J AU Shur, O Wu, J Cropek, DM Banta, S AF Shur, Oren Wu, Jun Cropek, Donald M. Banta, Scott TI Monitoring the conformational changes of an intrinsically disordered peptide using a quartz crystal microbalance SO PROTEIN SCIENCE LA English DT Article DE intrinsically disordered peptide; beta roll; quartz crystal microbalance; repeat-in-toxin domain; calcium-responsive peptide ID PROTEIN; MECHANISM; BINDING; SYSTEMS; PATHWAY AB Intrinsically disordered peptides (IDPs) have recently garnered much interest because of their role in biological processes such as molecular recognition and their ability to undergo stimulus-responsive conformational changes. The block V repeat-in-toxin motif of the Bordetella pertussis adenylate cyclase is an example of an IDP that undergoes a transition from a disordered state to an ordered beta roll conformation in the presence of calcium ions. In solution, a C-terminal capping domain is necessary for this transition to occur. To further explore the conformational behavior and folding requirements of this IDP, we have cysteine modified three previously characterized constructs, allowing for attachment to the gold surface of a quartz crystal microbalance (QCM). We demonstrate that, while immobilized, the C-terminally capped peptide exhibits similar calcium-binding properties to what have been observed in solution. In addition, immobilization on the solid surface appears to enable calcium-responsiveness in the uncapped peptides, in contrast to the behavior observed in solution. This work demonstrates the power of QCM as a tool to study the conformational changes of IDPs immobilized on surfaces and has implications for a range of potential applications where IDPs may be engineered and used including protein purification, biosensors, and other bionanotechnology applications. C1 [Shur, Oren; Wu, Jun; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Cropek, Donald M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. EM sbanta@columbia.edu FU Defense Threat Reduction Agency; U.S. Army FX Grant sponsor: Defense Threat Reduction Agency (SB/DMC) and the U.S. Army 6.1 Basic Research Program (SB/DMC). NR 25 TC 9 Z9 9 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0961-8368 EI 1469-896X J9 PROTEIN SCI JI Protein Sci. PD MAY PY 2011 VL 20 IS 5 BP 925 EP 930 DI 10.1002/pro.625 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 749DO UT WOS:000289442500015 PM 21416544 ER PT J AU Novak, TE AF Novak, Thomas E. TI Failed exstrophy closure SO SEMINARS IN PEDIATRIC SURGERY LA English DT Article DE Bladder exstrophy; Failed exstrophy; Urinary incontinence; Complications ID BLADDER EXSTROPHY; PRIMARY REPAIR; MANAGEMENT; RECONSTRUCTION; COMPLICATIONS; EPISPADIAS; EXPERIENCE; OUTCOMES; SUCCESS AB Children with bladder exstrophy present a formidable surgical challenge. Like all major reconstructive surgeries, the best hope for a favorable outcome lies in achieving success in the first operative attempt. Regardless of the surgical approach, however, complications do occur. A failed exstrophy closure is a major complication with significant implications on the long-term surgical outcome and ultimate fate of the urinary tract. Successful repeat exstrophy closure can be accomplished in most cases when performed in conjunction with pelvic osteotomy and proper postoperative immobilization. Modern staged repair of exstrophy, complete primary repair of exstrophy, and immediate continent urinary diversion have been advocated by different groups in the management of a failed exstrophy closure. It is apparent that compared with children who undergo successful primary closure, a failed closure with subsequent successful repeat closure makes the child much less likely to achieve sufficient bladder growth to be considered for bladder neck reconstruction, and furthermore, makes them less likely to have a successful bladder neck reconstruction ever, when they are an acceptable candidate. Although acceptable dryness rates after repeat closure can ultimately be obtained, they are typically at the expense of a commitment to intermittent catheterization and continent diversion. Published by Elsevier Inc. All rights reserved. C1 Brooke Army Med Ctr, Dept Surg, Div Urol, San Antonio, TX 78234 USA. RP Novak, TE (reprint author), Brooke Army Med Ctr, Dept Surg, Div Urol, San Antonio, TX 78234 USA. EM Thomas.novak@amedd.army.mil NR 15 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1055-8586 EI 1532-9453 J9 SEMIN PEDIATR SURG JI Semin. Pediatr. Surg. PD MAY PY 2011 VL 20 IS 2 BP 97 EP 101 DI 10.1053/j.sempedsurg.2010.12.004 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 751HA UT WOS:000289606900008 PM 21453853 ER PT J AU Sainato, R Flanagan, R Mahlen, S Fairchok, M Braun, L AF Sainato, Rebecca Flanagan, Ryan Mahlen, Steven Fairchok, Mary Braun, Loranee TI Severe human parechovirus sepsis beyond the neonatal period SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Sepsis; Fever; Human parechovirus ID ENTEROVIRUS; INFECTION; CHILDREN; DISEASE AB Here we describe a case of viral sepsis beyond the neonatal period caused by human parechovirus subtype 3 (HPeV-3), which manifested as cardio-respiratory failure, hepatitis, and necrotizing enterocolitis (NEC). HPeV-1 and 2 were originally classified as enteroviruses but the advent of sequence analysis led to them being recognized as a new genus in the picornavirus family. Subsequently, nine additional HPeV strains have been reported including HPeV-3 in 1999.(1) The spectrum of disease that these viruses may cause is still unknown, and they are rarely screened for in clinical practice. Published by Elsevier B. V. C1 [Sainato, Rebecca] Tripler Army Med Ctr, Dept Pediat, ATTN MCHK PE, Honolulu, HI 96859 USA. [Flanagan, Ryan; Fairchok, Mary; Braun, Loranee] Madigan Army Med Ctr, Dept Pediat, Attn MCHJ P, Ft Lewis, WA 98431 USA. [Mahlen, Steven] Madigan Army Med Ctr, Dept Pathol, Attn MCHJ PA, Ft Lewis, WA 98431 USA. RP Sainato, R (reprint author), Tripler Army Med Ctr, Dept Pediat, ATTN MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM rebecca.sainato@us.army.mil; ryanflanagan1@yahoo.com; steven.mahlen@amedd.army.mil; mary.fairchok@amedd.army.mil; Loranee.braun@us.army.mil NR 11 TC 12 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD MAY PY 2011 VL 51 IS 1 BP 73 EP 74 DI 10.1016/j.jcv.2011.02.009 PG 2 WC Virology SC Virology GA 746AN UT WOS:000289213400015 PM 21388870 ER PT J AU Chan, RK Liu, A Bojovic, B Chun, Y Guo, LF Caterson, SA Orgill, DP Pribaz, JJ AF Chan, Rodney K. Liu, Allen Bojovic, Branko Chun, Yoon Guo, Lifei Caterson, Stephanie A. Orgill, Dennis P. Pribaz, Julian J. TI Venous congestion in abdominal flap breast reconstructions - a simple treatment for a temporary problem SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY LA English DT Letter C1 [Chan, Rodney K.] USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Liu, Allen; Bojovic, Branko; Chun, Yoon; Guo, Lifei; Caterson, Stephanie A.; Orgill, Dennis P.; Pribaz, Julian J.] Brigham & Womens Hosp, Div Plast Surg, Dept Surg, Boston, MA 02445 USA. RP Chan, RK (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil OI Orgill, Dennis/0000-0002-8279-7310 NR 6 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1748-6815 J9 J PLAST RECONSTR AES JI J. Plast. Reconstr. Aesthet. Surg. PD MAY PY 2011 VL 64 IS 5 BP E135 EP E136 DI 10.1016/j.bjps.2010.12.017 PG 2 WC Surgery SC Surgery GA 746XX UT WOS:000289284800008 PM 21296041 ER PT J AU Thiruvengadathan, R Bezmelnitsyn, A Apperson, S Staley, C Redner, P Balas, W Nicolich, S Kapoor, D Gangopadhyay, K Gangopadhyay, S AF Thiruvengadathan, Rajagopalan Bezmelnitsyn, Andrey Apperson, Steven Staley, Clay Redner, Paul Balas, Wendy Nicolich, Steven Kapoor, Deepak Gangopadhyay, Keshab Gangopadhyay, Shubhra TI Combustion characteristics of novel hybrid nanoenergetic formulations SO COMBUSTION AND FLAME LA English DT Article DE Nanothermites; Combustion; Copper oxide; Nanorods; Nanoenergetic materials; Explosives ID REACTION PROPAGATION; CUO NANORODS; WAVE SPEEDS; COMPOSITES; NANOPARTICLES; ALUMINUM; REACTIVITY; THERMITES; IGNITION; EXPLOSIVES AB This paper presents the combustion characteristics of various copper oxide (CuO) nanorods/aluminum (Al) nanothermite compositions and hybrid nanoenergetic mixtures formed by combining nanothermites with either ammonium nitrate (NH(4)NO(3)) or secondary explosives such as RDX and CL-20 in different weight proportions. The different types of nanorods prepared in this study are referred to as CuO-VD (dried under vacuum at 25 degrees C for 24 h), CuO-100 (at 100 degrees C for 16 h) and CuO-400 (short time (1 min) calcination at 400 degrees C). The physical and chemical characteristics of these different kinds of CuO nanorods were determined using a variety of analytical tools such as X-ray diffractometer, transmission electron microscope (TEM). Fourier transform infrared spectrometer (MR), surface area analyzer and simultaneous differential scanning calorimeter (DSC)/thermogravimetric analyzer (TGA). These measured characteristics were correlated with the combustion behavior of the nanoenergetic compositions synthesized in this work. The use of different drying and calcination parameters produced the synthesis of CuO nanorods with varying amount of hydroxyl (OH) and CH(n) (n = 2, 3) functional groups. The experimental observations confirm that the presence of these functional groups on the surface of CuO nanorods enabled the formation of assembled nanoenergetic composite, upon mixed with Al nanoparticles. A facile one-step synthesis of assembled composite through surface functionalization is reported and it can be extended to large-scale preparation of assembled nanoenergetic mixtures. The combustion behavior was studied by measuring both combustion wave speed and pressure-time characteristics. Pressurization rate was determined by monitoring the pressure-time characteristics during the combustion reaction initiated by a hot wire in a fully-confined geometry. Different amounts of nanothermite powder were packed in the same volume of combustion chamber by applying different packing pressures and the pressure-time characteristics were measured as a function of varying percent theoretical maximum density (% TMD). The experimental setup used in this work enabled us to study the functional behavior of initiating explosives such as NH4NO3 nanoparticles, RDX and CL-20 using nanothermites under fully-confined test geometry. The dent tests performed on lead witness plates support the experimental observations obtained from pressure-time and combustion wave speed measurements of hybrid mixtures. (C) 2011 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Thiruvengadathan, Rajagopalan; Gangopadhyay, Keshab; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Bezmelnitsyn, Andrey; Apperson, Steven; Gangopadhyay, Keshab] NEMS MEMS Works LLC, Columbia, MO 65203 USA. [Redner, Paul; Balas, Wendy; Nicolich, Steven; Kapoor, Deepak] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Gangopadhyay, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM gangopadhyays@missouri.edu OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 FU US Army ARDEC, Picatinny, New Jersey [W15QKN-06-D-0031, W15QKN-08-C-0430] FX The authors gratefully acknowledge the financial support by US Army ARDEC, Picatinny, New Jersey (Grant # W15QKN-06-D-0031 and W15QKN-08-C-0430). NR 34 TC 29 Z9 31 U1 3 U2 38 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAY PY 2011 VL 158 IS 5 BP 964 EP 978 DI 10.1016/j.combustflame.2011.02.004 PG 15 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 743UA UT WOS:000289043000014 ER PT J AU Gallow, KC Jhon, YK Tang, W Genzer, J Loo, YL AF Gallow, Keith C. Jhon, Young K. Tang, Wei Genzer, Jan Loo, Yueh-Lin TI Cloud Point Suppression in Dilute Solutions of Model Gradient Copolymers with Prespecified Composition Profiles SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE atom transfer radical polymerization; cloud point; composition profile; dimethylaminoethyl methacrylate; dilute aqueous solutions; gradient copolymers; gradient strength; hydroxyethyl methacrylate; monomer sequence distribution ID GLASS-TRANSITION TEMPERATURES; BLOCK-COPOLYMER AB Gradient copolymers of 2-hydroxyethyl methacrylate (HEMA) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) having prescribed linear, parabolic, and hyperbolic composition profiles were synthesized with the guidance of a numerical model that determines the instantaneous comonomer feed rate. These materials exhibit low polydispersity indices (<1.1); the evolution of the overall DMAEMA content and the absolute molecular weight of the copolymers are all in good agreement with the quantities predicted by our model. Compared to random copolymers of HEMA and DMAEMA, the cloud points of dilute buffered aqueous solutions of gradient copolymers decrease with increasing gradient strength; where the gradient strength is defined as the largest difference in the instantaneous composition along the copolymer. The temperature range over which the solutions transition from transparent to turbid also broadens significantly with increasing gradient strength. Both observations suggest the onset of transition to be dictated by the least soluble ends of the polymer chains. These correlations point to the importance of monomer sequence distribution in determining the macroscopic physical properties of copolymers. (C) 2011 Wiley Periodicals, Inc. J PolymSci Part B: Polym Phys 49: 629-637, 2011 C1 [Gallow, Keith C.; Tang, Wei; Loo, Yueh-Lin] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA. [Jhon, Young K.; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Jhon, Young K.] USA, Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA. RP Loo, YL (reprint author), Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA. EM lloo@princeton.edu RI Loo, Yueh-Lin/C-6607-2011 FU National Science Foundation [NSF-PIRE 0730243]; Faculty Early Career Development Program [0753148]; Office of International Science and Engineering [OISE-0730243]; National Research Council Research Associateship at the Army Research Office FX This work is funded by the National Science Foundation's Partnerships for International Research and Education (NSF-PIRE 0730243), the Faculty Early Career Development Program (NSF-CAREER 0753148), and the Office of International Science and Engineering (OISE-0730243). Y. K. Jhon thanks the National Research Council Research Associateship Award at the Army Research Office. The authors thank Enrique Gomez for assistance with LabView programming. NR 64 TC 16 Z9 17 U1 1 U2 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD MAY 1 PY 2011 VL 49 IS 9 BP 629 EP 637 DI 10.1002/polb.22226 PG 9 WC Polymer Science SC Polymer Science GA 742TK UT WOS:000288967200002 ER PT J AU Chu-Agor, ML Munoz-Carpena, R Kiker, G Emanuelsson, A Linkov, I AF Chu-Agor, M. L. Munoz-Carpena, R. Kiker, G. Emanuelsson, A. Linkov, I. TI Exploring vulnerability of coastal habitats to sea level rise through global sensitivity and uncertainty analyses SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Global sensitivity analysis; Global uncertainty analysis; Fate of coastal habitats; Charadrius sp; SLAMM 5; Plover habitats; Model evaluation ID CLIMATE-CHANGE; ECOSYSTEM SERVICES; MODELS; SHOREBIRDS; IMPACTS; JERSEY; BIRDS; UK AB Changes in coastal habitats brought about by climate change have the potential to cause population decline of shoreline dependent organisms. In particular, sea level rise associated with climate change can drastically affect wetlands and beaches which are important foraging and nesting areas of these organisms. SLAMM 5 (Sea Level Affecting Marshes Model) is widely used to simulate wetland conversion and shoreline modification for the purpose of habitat vulnerability assessment and decision making, but concerns regarding the suitability of the model due to the uncertainty involved in selecting many of the model's empirical input parameters have been expressed. This paper applies a generic evaluation framework consisting of a state-of-the-art screening and variance-based global sensitivity and uncertainty analyses to simulate changes in the coastal habitats of the barrier island in Eglin Air Force Base, Florida in order to: (1) identify the important input factors and processes that control SLAMM 5's output uncertainty; (2) quantify SLAMM 5's global output uncertainty and apportion it to the direct contributions and interactions of the important input factors; and (3) evaluate this new methodology to explore the potential fate of the coastal habitats of the study area. Results showed that four input factors (DEM vertical error for the lower elevation range, historic trend of sea level rise, accretion, and sedimentation rates) controlled 88-91% of SLAMM 5's output variance in predicting changes in the beach habitat of Eglin Air Force Base. The most dominant processes governing the fate of the coastline of the study area were inundation (i.e. reduction in elevation due to sea level rise) and accretion/sedimentation. Interestingly, for lower elevation habitats (salt marsh, tidal flat, and beach), results showed possible gain or loss of these habitats depending on the relative strength of these processes resulting from the combination of input factors within their proposed uncertainty ranges. Higher-elevation habitats (swamps and inland fresh marsh) showed decrease in area over 100 years of simulation. These findings are important to implement managerial schemes in the area to protect threatened Plover birds (Charadrius sp.) communities. This generic model evaluation framework is model-independent and can be used to evaluate a wide range of environmental models. (c) 2010 Elsevier Ltd. All rights reserved. C1 [Chu-Agor, M. L.; Munoz-Carpena, R.; Kiker, G.; Emanuelsson, A.] Univ Florida, Agr & Biol Engn Dept, Gainesville, FL 32611 USA. [Linkov, I.] USA, Engineer Res & Dev Ctr, Concord, MA 01366 USA. RP Munoz-Carpena, R (reprint author), Univ Florida, Agr & Biol Engn Dept, POB 110570, Gainesville, FL 32611 USA. EM carpena@ufl.edu RI Munoz-Carpena, Rafael/A-7588-2010; OI Munoz-Carpena, Rafael/0000-0003-2838-1514; Chu, Ma Librada/0000-0003-3732-7165 FU University of Florida High Performance Computing Center; U.S. Department of Defense; Strategic Environmental Research and Development Program (SERDP) [SI-1699] FX The authors acknowledge the help of Jonathan S. Clough, Dr. Richard A. Fischer, Dr. Matteo Convertino, and the computational resources and support of the University of Florida High Performance Computing Center (http://hpc.ufl.edu). This effort was sponsored by the U.S. Department of Defense and Strategic Environmental Research and Development Program (SERDP, SI-1699, PI: I. Linkov). Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 61 TC 60 Z9 67 U1 10 U2 96 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD MAY PY 2011 VL 26 IS 5 BP 593 EP 604 DI 10.1016/j.envsoft.2010.12.003 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 722MT UT WOS:000287437100005 ER PT J AU Zhang, SS Ren, XM Read, J AF Zhang, Sheng S. Ren, Xiaoming Read, Jeffrey TI Heat-treated metal phthalocyanine complex as an oxygen reduction catalyst for non-aqueous electrolyte Li/air batteries SO ELECTROCHIMICA ACTA LA English DT Article DE Oxygen reduction; Electrocatalysis; Metal phthalocyanine complex; Air electrode; Li/air battery ID LI-ION BATTERIES; O-2 REDUCTION; CATHODES; CARBON; ELECTROCATALYSTS; MOSSBAUER; PORPHYRIN AB In this work we study heat-treated FeCu-phthalocyanine (FeCuPc) complexes as the catalyst for oxygen reduction in non-aqueous electrolyte Li/air cells by supporting the catalyst on a high surface area Ketjenblack EC-600JD carbon black. It is shown that the resultant FeCu/C catalyst not only accelerates the two-electron reduction of oxygen as "O(2) + 2Li(+) + 2e -> Li(2)O(2)", but also catalyzes the chemical disproportionation of Li(2)O(2) as "2Li(2)O(2) -> 2Li(2)O + O(2)". In Li/air cells, the catalyst reduces polarization on discharge while simultaneously reducing the fraction of Li(2)O(2) in the final discharged products. In a 0.2 mol kg(-1) LiSO(3)CF(3) 7:3 (wt.) propylene carbonate (PC)/tris(2,2,2-trifluoroethyl) phosphate (TFP) electrolyte, the Li/air cells with FeCu/C show at least 0.2V higher discharge voltage at 0.2 mA cm(-2) than those with pristine carbon. By measuring the charge-transfer resistance (R(ct)) of Li/air cells at temperatures ranging between -30 degrees C and 30 degrees C, we determine the apparent activation energy of the discharge of Li/air cells and discuss the effect of FeCu/C catalyst on the oxygen reduction in Li/air cells. Published by Elsevier Ltd. C1 [Zhang, Sheng S.; Ren, Xiaoming; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shengshui.zhang@us.army.mil RI ren, xiaoming/F-3953-2011; dong, guofa/D-5248-2011; Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 28 TC 44 Z9 45 U1 1 U2 53 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD APR 30 PY 2011 VL 56 IS 12 BP 4544 EP 4548 DI 10.1016/j.electacta.2011.02.072 PG 5 WC Electrochemistry SC Electrochemistry GA 765JL UT WOS:000290701500018 ER PT J AU Smith, TJ Schwarz, JM Montain, SJ Rood, J Pikosky, MA Castaneda-Sceppa, C Glickman, E Young, AJ AF Smith, Tracey J. Schwarz, Jean-Marc Montain, Scott J. Rood, Jennifer Pikosky, Matthew A. Castaneda-Sceppa, Carmen Glickman, Ellen Young, Andrew J. TI High protein diet maintains glucose production during exercise-induced energy deficit: a controlled trial SO NUTRITION & METABOLISM LA English DT Article DE carbohydrate metabolism gluconeogenesis; protein intake; negative energy balance; stable isotopes ID WEIGHT-LOSS; NITROGEN-BALANCE; BODY-COMPOSITION; STABLE-ISOTOPE; ADULT WOMEN; METABOLISM; MEN; GLUCONEOGENESIS; CARBOHYDRATE; TURNOVER AB Background: Inadequate energy intake induces changes in endogenous glucose production (GP) to preserve muscle mass. Whether addition provision of dietary protein modulates GP response to energy deficit is unclear. The objective was to determine whether exercise-induced energy deficit effects on glucose metabolism are mitigated by increased dietary protein. Methods: Nineteen men ([mean +/- SD] 23 +/- 2 y, VO(2peak) 59 +/- 5 ml.kg(-1).min(-1)) were divided into three groups, two consuming moderate (MP; 0.9 g protein kg(-1) d(-1)), and one high (HP; 1.8 g protein kg(-1) d(-1)) protein diets (55% energy from carbohydrate) for 11 days. Following 4 days of energy balance (D1-4), energy expenditure was increased for 7 days (D5-12) in all groups. Energy intake was unchanged in two, creating a 1000 kcal d(-1) deficit (DEF-MP, DEF-HP; n = 6, both groups), whereas energy balance was maintained in the third (BAL-MP, n = 7). Biochemical markers of substrate metabolism were measured during fasting rest on D4 and D12, as were GP and contribution of gluconeogenesis to endogenous glucose production (f(gng)) using 4-h primed, continuous infusions of [6,6-(2)H(2)] glucose (dilution-method) and [2-(13)C] glycerol (MIDA technique). Glycogen breakdown (GB) was derived from GP and f(gng). Results: Plasma beta-hydroxybutyrate levels increased, and plasma glucose and insulin declined from D4 to D12, regardless of group. DEF-MP experienced decreased plasma GP from D4 to D12 ([mean change +/- SD] 0.24 +/- 0.24 mg.kg(-1).min(-1)), due to reduced GB from D4 (1.40 +/- 0.28 mg.kg(-1).min(-1)) to D12 (1.16 +/- 0.17 mg.kg(-1).min(-1)), P < 0.05. Conversely, BAL-MP and DEF-HP sustained GP from D4 to D12 ([mean change +/- SD] 0.1 +/- 0.5 and 0.0 +/- 0.2 mg.kg(-1).min(-1), respectively) by maintaining GB. Conclusion: Exercise-induced energy deficit decreased GP and additional dietary protein mitigated that effect. C1 [Smith, Tracey J.; Montain, Scott J.; Pikosky, Matthew A.; Glickman, Ellen; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Schwarz, Jean-Marc; Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Schwarz, Jean-Marc] Touro Univ, Dept Osteopath Med, Vallejo, CA 94592 USA. [Castaneda-Sceppa, Carmen] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. RP Smith, TJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM tracey.j.smith@us.army.mil FU U.S. Army Medical Research and Materiel Command FX This work was funded by the U.S. Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the Army or the Department of Defense. NR 34 TC 3 Z9 3 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-7075 J9 NUTR METAB JI Nutr. Metab. PD APR 28 PY 2011 VL 8 AR 26 DI 10.1186/1743-7075-8-26 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 767OY UT WOS:000290867100001 PM 21527019 ER PT J AU Bahta, M Lountos, GT Dyas, B Kim, SE Ulrich, RG Waugh, DS Burke, TR AF Bahta, Medhanit Lountos, George T. Dyas, Beverly Kim, Sung-Eun Ulrich, Robert G. Waugh, David S. Burke, Terrence R., Jr. TI Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH) Phosphatase SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TYROSINE-PHOSPHATASE; PROMISCUOUS INHIBITORS; NONPEPTIDIC INHIBITORS; RAPID IDENTIFICATION; INORGANIC-PHOSPHATE; POTENT INHIBITORS; MECHANISM; LIBRARY; 1B; SPECIFICITY AB Our current study reports the first K(M) optimization of a library of nitrophenylphosphate-containing substrates for generating an inhibitor lead against the Yersinia pestis outer protein phosphatase (YopH). A high activity substrate identified by this method (K(M) = 80 mu M) was converted from a subs trate into an inhibitor by replacement of its phosphate group with difluoromethylphosphonic acid, and by attachment of an aminooxy handle for further structural optimization by mime ligation. A cocrystal structure of this aminooxy-containing platform in complex with YopH allowed the identification of a conserved water molecule proximal to the aminooxy group that was subsequenly employed for the design of furanyl-based oxime derivatives. By this process, a potent (IC(50) = 190 nM) and nonpromiscuous inhibitor was developed with good YopH selectivity relative to a panel of phosphatases. The inhibitor showed significant inhibition Of intracellular Y pestis replication at a noncytotoxic concentration. The current work presents general approaches to PTP inhibitor development that may be useful beyond YopH. C1 [Bahta, Medhanit; Kim, Sung-Eun; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA. [Lountos, George T.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA. [Dyas, Beverly; Ulrich, Robert G.] USA, Lab Mol Immunol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Burke, TR (reprint author), NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA. EM tburke@helix.nih.gov RI Burke, Terrence/N-2601-2014; Lountos, George/B-3983-2015 FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]; NIH, Center for Cancer Research; NCI-Frederick; National Cancer Institute, National Institutes of Health; Joint Science and Technology Office of the Department of Defense FX Appreciation is expressed to Afroz Sultana (LMI) far technical support and to Joseph Tropea and Scott Cherry (MCL) for assistance with the production of phosphatases. Electrospray mass spectrometry experiments were conducted on the LC/ESMS instrument maintained by the Biophysics Resource in the Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute at Frederick. X-ray diffraction data were collected at the Southeast Regional Collaborative Access Team (SER-CAT) beamline 22-ID at the Advanced Photon Source, Argonne National Laboratory. Supporting institutions may be found at http://www.ser-cat.org/members.html. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-Eng-38. This work was supported in part by the Intramural Research Program of the NIH, Center for Cancer Research, NCI-Frederick and the National Cancer Institute, National Institutes of Health, and the Joint Science and Technology Office of the Department of Defense. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. NR 80 TC 29 Z9 29 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 28 PY 2011 VL 54 IS 8 BP 2933 EP 2943 DI 10.1021/jm200022g PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 752ND UT WOS:000289697800028 PM 21443195 ER PT J AU Sirk, TW Friedman, M Brown, EF AF Sirk, Timothy W. Friedman, Mendel Brown, Eugene F. TI Molecular Binding of Black Tea Theaflavins to Biological Membranes: Relationship to Bioactivities SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE Theaflavin; lipid bilayer; modeling; membrane affinity; teas ID PARTICLE MESH EWALD; INDUCED TOXICITY; HPLC ANALYSIS; HEPG2 CELLS; GREEN; CATECHINS; DYNAMICS; CAFFEINE; CANCER; LEAVES AB Molecular dynamics simulations were used to study the interactions of three theaflavin compounds with lipid bilayers. Experimental studies have linked theaflavins to beneficial health effects, some of which are related to interactions with the cell membrane. The molecular interaction of theaflavins with membranes was explored by simulating the interactions of three theaflavin molecules (theaflavin, theaflavin-3-gallate, and theaflavin-3,3'-digallate) with a mixed bilayer composed of 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) and 1-palmitoy1-2-oleoyl phosphatidylethanolamine (POPE). The simulations show that the theaflavins evaluated have an affinity for the lipid bilayer surface via hydrogen bonding. The molecular structure of theaflavins influenced their configuration when binding to the bilayer surface, as well as their ability to form hydrogen bonds with the lipid headgroups. The theaflavin bilayer interactions studied here help to define structure function relationships of the theaflavins and provide a better understanding of the role of theaflavins in biological processes. The significance of the results are discussed in the context of black tea composition and bioactivity. C1 [Sirk, Timothy W.] USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA. [Friedman, Mendel] ARS, Western Reg Res Ctr, USDA, Albany, CA 94710 USA. [Brown, Eugene F.] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA. RP Sirk, TW (reprint author), USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA. EM tim.sirk@us.army.mil OI Friedman, Mendel/0000-0003-2582-7517 NR 56 TC 23 Z9 24 U1 3 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD APR 27 PY 2011 VL 59 IS 8 BP 3780 EP 3787 DI 10.1021/jf2006547 PG 8 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 751JN UT WOS:000289613500038 PM 21417313 ER PT J AU Yoon, SC Hurst, FP Jindal, RM George, SA Neff, RT Agodoa, LY Kimmel, PL Abbott, KC AF Yoon, Sylvia C. Hurst, Frank P. Jindal, Rahul M. George, Susan A. Neff, Robert T. Agodoa, Lawrence Y. Kimmel, Paul L. Abbott, Kevin C. TI Trends in Renal Transplantation in Patients With Human Immunodeficiency Virus Infection: An Analysis of the United States Renal Data System SO TRANSPLANTATION LA English DT Article DE HIV nephropathy; Transplant outcomes; Transplantation; AIDS ID ACTIVE ANTIRETROVIRAL THERAPY; SOLID-ORGAN TRANSPLANTATION; HIV-INFECTION; KIDNEY; SURVIVAL; NEPHROPATHY; DISEASES; SAFETY AB Background. We examined the United States Renal Data System registry to analyze trends in renal transplantation in patients with human immunodeficiency virus (HIV) infection. Methods. A retrospective cohort study was performed using the United States Renal Data System, analyzing patients receiving renal transplants from January 1, 1995, to September 29, 2006. Factors independently associated with transplantation in HIV-infected patients with end-stage renal disease were identified. Results. There was a significant increase in renal transplant recipients who were HIV seropositive who received renal transplants from 2001 to 2006 (n = 208, 0.26%) versus 1995 to 2000 era (n = 43, 0.06%, P < 0.001). Before 2001, only 18 states performed renal transplants in HIV-infected patients, whereas most states transplanted HIV-infected patients in the second era. There were more African American recipients with HIV infection from 2001 to 2006 compared with the earlier cohort (n = 118 vs. 8, P < 0.001). Patients with HIV infection were more likely to have received induction therapy (n = 121 vs. 37, P < 0.001) and tacrolimus maintenance suppression (n = 105 vs. 13, P < 0.001) in the latter era. There were also more deceased donor transplants from 2001 to 2006 (n = 143 vs. 25, P < 0.001). In logistic regression analysis, when adjusted for multiple factors including recipient and donor age, race, gender, and donor type, patients with HIV infection were more likely to have been transplanted after 2001 (adjusted odds ratio, 2.21; 95% confidence interval = 1.49-3.28). In analysis adjusted for multiple factors including hepatitis C virus coinfection, HIV infection was not significantly associated with all-cause graft loss. Conclusions. There has been a dramatic increase in the number of transplants among HIV-infected patients. These findings suggest improved access to transplant wait listing and better management of immunosuppression, especially among African American patients. C1 [Yoon, Sylvia C.; Hurst, Frank P.; Jindal, Rahul M.; George, Susan A.; Neff, Robert T.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Yoon, Sylvia C.; Hurst, Frank P.; Jindal, Rahul M.; George, Susan A.; Neff, Robert T.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. [Jindal, Rahul M.; Kimmel, Paul L.] George Washington Univ, Dept Med, Washington, DC USA. [Agodoa, Lawrence Y.; Kimmel, Paul L.] NIDDK, NIH, Bethesda, MD USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Dept Organ Transplant, 6630 Georgia Ave, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 21 TC 13 Z9 13 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD APR 27 PY 2011 VL 91 IS 8 BP 864 EP 868 DI 10.1097/TP.0b013e31820f081f PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 746VX UT WOS:000289277000011 PM 21301399 ER PT J AU Nyein, MK Jason, AM Yu, L Pita, CM Joannopoulos, JD Moore, DF Radovitzky, R AF Nyein, Michelle K. Jason, Amanda M. Yu, Li Pita, Claudio M. Joannopoulos, John D. Moore, David F. Radovitzky, Raul TI Reply to Moss et al.: Military and medically relevant models of blast-induced traumatic brain injury vs. ellipsoidal heads and helmets SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Letter C1 [Nyein, Michelle K.; Jason, Amanda M.; Yu, Li; Pita, Claudio M.; Joannopoulos, John D.; Radovitzky, Raul] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. [Nyein, Michelle K.; Jason, Amanda M.; Yu, Li; Pita, Claudio M.; Radovitzky, Raul] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. [Joannopoulos, John D.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Radovitzky, R (reprint author), MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM rapa@mit.edu RI Radovitzky, Raul/A-5353-2009 OI Radovitzky, Raul/0000-0001-6339-2708 NR 4 TC 1 Z9 1 U1 0 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 26 PY 2011 VL 108 IS 17 BP E83 EP E83 DI 10.1073/pnas.1102626108 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 754WM UT WOS:000289888500002 ER PT J AU Grujicic, M Pandurangan, B Bell, WC Cheeseman, BA Yen, CF Randow, CL AF Grujicic, M. Pandurangan, B. Bell, W. C. Cheeseman, B. A. Yen, C. -F. Randow, C. L. TI Molecular-level simulations of shock generation and propagation in polyurea SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Polyurea; Shock-wave generation and propagation; Molecular-level calculations ID VINYL-ESTER-EPOXY; MECHANICAL-PROPERTIES; FORCE-FIELD; TRANSITION; CAPABILITY; DYNAMICS; COMPASS AB A non-equilibrium molecular dynamics method is employed in order to study various phenomena accompanying the generation and propagation of shock waves in polyurea (a micro-phase segregated elastomer). Several recent studies reported in the literature suggested that polyurea has a relatively high potential for mitigation of the effects associated with blast and ballistic impact. This behavior of polyurea is believed to be closely related to its micro-phase segregated microstructure (consisting of the so-called "hard domains" and a soft matrix) and to different phenomena/processes (e.g. inelastic-deformation and energy-dissipation) taking place at, or in the vicinity of, the shock front. The findings obtained in the present analysis are used to help elucidate the molecular-level character of these phenomena/processes. In addition, the analysis yielded the shock Hugoniot (i.e. a set of axial stress vs. density/specific-volume vs. internal energy vs. particle velocity vs. temperature vs. shock speed) material states obtained in polyurea after the passage of a shock wave. The availability of a shock Hugoniot is critical for construction of a high deformation-rate, large-strain, high pressure material models which can be used within a continuum-level computational analysis to capture the response of a polyurea-based macroscopic structure (e.g. blast-protection helmet suspension pads) to blast/ballistic impact loading. (C) 2011 Elsevier B.V. All rights reserved. C1 [Grujicic, M.; Pandurangan, B.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Yen, C. -F.; Randow, C. L.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU Office of Naval Research (ONR) through the Pennsylvania State University [4036-CU-ONR-1125]; Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory (ARL) [W911NF-06-2-0042] FX The material presented in this paper is based on work supported by the Office of Naval Research (ONR) research contract entitled "Elastomeric Polymer-By-Design to Protect the Warfighter Against Traumatic Brain Injury by Diverting the Blast Induced Shock Waves from the Head", Contract Number 4036-CU-ONR-1125 as funded through the Pennsylvania State University, the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites", Contract Number W911NF-09-1-0513, and the Army Research Laboratory (ARL) research contract entitled "Computational Analysis and Modeling of Various Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil" Contract Number W911NF-06-2-0042. The authors are indebted to Drs. Roshdy Barsoum of ONR and Bruce LaMattina of ARO for their continuing support and interest in the present work. The authors also want to thank professors J. Runt, J. Tarter, G. Settles, G. Dillon and M. Hargether for stimulating discussions and friendship. NR 21 TC 28 Z9 28 U1 1 U2 31 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD APR 25 PY 2011 VL 528 IS 10-11 BP 3799 EP 3808 DI 10.1016/j.msea.2011.01.081 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 742VQ UT WOS:000288973800037 ER PT J AU Yathindranath, V Rebbouh, L Moore, DF Miller, DW van Lierop, J Hegmann, T AF Yathindranath, Vinith Rebbouh, Leila Moore, David F. Miller, Donald W. van Lierop, Johan Hegmann, Torsten TI A Versatile Method for the Reductive, One-Pot Synthesis of Bare, Hydrophilic and Hydrophobic Magnetite Nanoparticles SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID SUPERPARAMAGNETIC IRON-OXIDE; BIOMEDICAL APPLICATIONS; MONODISPERSED COLLOIDS; FE3O4 NANOPARTICLES; SIZE; NANOCRYSTALS; AGENT; CRYSTALLINE; PARTICLES; MECHANISM AB A biocompatible, reliable, and particularly versatile synthesis of magnetic iron oxide nanoparticles (IONPs) is presented that uses iron(III) acetylacetonate Fe(acac) 3 as an iron precursor and sodium borohydride as a reducing agent. Both the reaction temperature and the concentration of the reducing agent have considerable effects on the IONP size. These dependencies can be used to prepare IONPs ranging in size from 5 to 8 nm, as determined by transmission electron microscopy (TEM). Synthesis at room temperature or with higher sodium borohydride concentrations always resulted in smaller particle sizes. Powder X-ray diffraction patterns show the presence of an iron oxide phase with a cubic unit cell and allow for the determination of the lattice parameters and average crystallite sizes for all synthesized IONPs. Transmission Mssbauer spectroscopy shows that the as-synthesized IONPs are pure magnetite (Fe3O4) and is further used to elucidate the reaction pathway by analyzing iron intermediates formed prior to nanoparticle formation and precipitation. TEM and high-resolution TEM reveal quasi-spherical shapes and lattice fringes for most IONPs. With only minor modifications of the synthesis procedure, this versatile, one-pot synthesis is proven to be suitable for the production of bare (uncoated) IONPs, IONPs with hydrophilic poly(ethylene glycol), L-arginine, and L-glutamic acid coatings, as well as IONPs with hydrophobic coatings such as oleic acid. All coated IONPs were characterized by FT-IR spectroscopy. In addition, the bare IONPs could easily be modified post-synthesis with a suitable capping agent using ultrasonication. To verify the biocompatibility of the IONPs, in vitro cytotoxicity studies were carried out on bare IONPs with intestinal (Caco2) and liver epithelial (HepG2) cell cultures using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Phase contrast microscopy after hematoxylin-eosin staining showed the intact morphology of the Caco2 and HepG2 cells treated with IONPs. C1 [Yathindranath, Vinith; Hegmann, Torsten] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada. [Rebbouh, Leila; van Lierop, Johan] Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada. [Miller, Donald W.] Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada. [Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Yathindranath, V (reprint author), Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada. EM hegmannt@cc.umanitoba.ca FU Shire Human Genetics Therapy; Manitoba Medical Service Foundation; Defense and Veterans Brain Injury Center; Canada Foundation for Innovation (CFI); Manitoba Research and Innovation Fund (MRIF); Natural Sciences and Engineering Research Council (NSERC) of Canada; University of Manitoba FX We acknowledge financial support from Shire Human Genetics Therapy, the Manitoba Medical Service Foundation, the Defense and Veterans Brain Injury Center, the Canada Foundation for Innovation (CFI), The Manitoba Research and Innovation Fund (MRIF), and the Natural Sciences and Engineering Research Council (NSERC) of Canada. V.Y. gratefully acknowledges financial support from the University of Manitoba Graduate Fellowship program (UMGF). We also acknowledge access to and assistance with XRD measurements from Dr. Bieringer and his group (Department of Chemistry, University of Manitoba), Prof. Hawthorne and Neil Ball (Geological Sciences, University of Manitoba), and Prof. J. M. Cadogan (Department of Physics & Astronomy, University of Manitoba). We thank Fang Chen and Martha Hinton for their assistance with the cell cultures. Finally, we also acknowledge Dr. G. de Silveira at the Canadian Centre for Electron Microscopy, CCEM (McMaster University, Brockhouse Institute) for TEM, HR-TEM, and SAED experiments. Note: This article has been amended on April 22, 2011 to correct a typographical error to the space group on page 3, line 17 in the version first published online. NR 49 TC 38 Z9 38 U1 8 U2 104 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1616-301X J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD APR 22 PY 2011 VL 21 IS 8 BP 1457 EP 1464 DI 10.1002/adfm.201002111 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 751SS UT WOS:000289638500014 ER PT J AU Munday, LB Chung, PW Rice, BM Solares, SD AF Munday, Lynn B. Chung, Peter W. Rice, Betsy M. Solares, Santiago D. TI Simulations of High-Pressure Phases in RDX SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS; CYCLOTRIMETHYLENE-TRINITRAMINE; CRYSTAL-STRUCTURE; SINGLE-CRYSTALS; PENTAERYTHRITOL TETRANITRATE; FORCE-FIELD; EXPLOSIVES; CHEMISTRY AB Using a fully flexible molecular potential in equilibrium molecular dynamics simulations, we study the alpha-and gamma-polymorphs of the energetic molecular crystal hexahydro-1,3,5-trinitro-s-triazine (RDX), their respective properties, and the conditions that contribute to the stress-induced gamma -> alpha solid-solid phase transition mechanisms. We find the pressure-dependent atomic structure, mechanical properties, and transition behavior to be described reasonably well. Uniaxial deformation of alpha-RDX along the crystal axes is shown to result in three different crystal responses where compression of the c-axis results in the alpha -> gamma transition, compression of the b-axis causes a transition with resulting structure similar to stacking faults observed by Cawkwell et al. [J. Appl. Phys. 2010, 107, 063512], and no transitions are observed for compression of the a-axis. C1 [Munday, Lynn B.; Chung, Peter W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Munday, Lynn B.; Solares, Santiago D.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Chung, PW (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Research Laboratory; DoD Higher Performance Computing Modernization Office through the Multiscale Reactive Modeling of Insensitive Munitions Software Applications Institute FX Support is gratefully acknowledged from the U.S. Army Research Laboratory STEP program and the DoD Higher Performance Computing Modernization Office through the Multiscale Reactive Modeling of Insensitive Munitions Software Applications Institute. Computing support was provided by the DoD Supercomputing Resource Center located at the Army Research Laboratory. NR 34 TC 56 Z9 56 U1 1 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD APR 21 PY 2011 VL 115 IS 15 BP 4378 EP 4386 DI 10.1021/jp112042a PG 9 WC Chemistry, Physical SC Chemistry GA 748PO UT WOS:000289403100013 PM 21434619 ER PT J AU Burnworth, M Tang, LM Kumpfer, JR Duncan, AJ Beyer, FL Fiore, GL Rowan, SJ Weder, C AF Burnworth, Mark Tang, Liming Kumpfer, Justin R. Duncan, Andrew J. Beyer, Frederick L. Fiore, Gina L. Rowan, Stuart J. Weder, Christoph TI Optically healable supramolecular polymers SO NATURE LA English DT Article ID HYDROGEN-BONDING INTERACTIONS; POLY(P-PHENYLENE ETHYNYLENE)S; POLYMERIZATION; ROUTE AB Polymers with the ability to repair themselves after sustaining damage could extend the lifetimes of materials used in many applications(1). Most approaches to healable materials require heating the damaged area(2-4). Here we present metallosupramolecular polymers that can be mended through exposure to light. They consist of telechelic, rubbery, low-molecular-mass polymers with ligand end groups that are non-covalently linked through metal-ion binding. On exposure to ultraviolet light, the metal-ligand motifs are electronically excited and the absorbed energy is converted into heat. This causes temporary disengagement of the metal-ligand motifs and a concomitant reversible decrease in the polymers' molecular mass and viscosity(5), thereby allowing quick and efficient defect healing. Light can be applied locally to a damage site, so objects can in principle be healed under load. We anticipate that this approach to healable materials, based on supramolecular polymers and a light-heat conversion step, can be applied to a wide range of supramolecular materials that use different chemistries. C1 [Burnworth, Mark; Tang, Liming; Kumpfer, Justin R.; Rowan, Stuart J.; Weder, Christoph] Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA. [Duncan, Andrew J.; Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fiore, Gina L.; Weder, Christoph] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland. [Fiore, Gina L.; Weder, Christoph] Univ Fribourg, Fribourg Ctr Nanomat, CH-1700 Fribourg, Switzerland. RP Rowan, SJ (reprint author), Case Western Reserve Univ, Dept Macromol Sci & Engn, 2100 Adelbert Rd, Cleveland, OH 44106 USA. EM stuart.rowan@case.edu; christoph.weder@unifr.ch RI Weder, Christoph/K-7453-2012; OI Merkle Institute, Adolphe/0000-0002-6220-424X FU US Army Research Office [W911NF-09-1-0288, W911NF-06-1-0414]; National Science Foundation [CHE-0704026, DMR-0602869, MRI-0821515]; Adolphe Merkle Foundation; US Army Research Laboratory [ORISE-1120-1120-99]; US Department of Energy [ORISE-1120-1120-99] FX This material is based on work supported by the US Army Research Office (W911NF-09-1-0288 and W911NF-06-1-0414); the National Science Foundation under grant numbers CHE-0704026, DMR-0602869 and MRI-0821515; the Adolphe Merkle Foundation; and the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (contract number ORISE-1120-1120-99). We thank S. Dellinger for the design and the fabrication of a device to introduce well-defined defects and Kraton Performance Polymers Inc for the donation of the hydroxyl-terminated poly(ethylene-co-butylene). NR 27 TC 550 Z9 558 U1 50 U2 485 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD APR 21 PY 2011 VL 472 IS 7343 BP 334 EP U230 DI 10.1038/nature09963 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 752VW UT WOS:000289724600036 PM 21512571 ER PT J AU Lin, JT Bethell, D Tyner, SD Lon, C Shah, NK Saunders, DL Sriwichai, S Khemawoot, P Kuntawunggin, W Smith, BL Noedl, H Schaecher, K Socheat, D Se, Y Meshnick, SR Fukuda, MM AF Lin, Jessica T. Bethell, Delia Tyner, Stuart D. Lon, Chanthap Shah, Naman K. Saunders, David L. Sriwichai, Sabaithip Khemawoot, Phisit Kuntawunggin, Worachet Smith, Bryan L. Noedl, Harald Schaecher, Kurt Socheat, Duong Se, Youry Meshnick, Steven R. Fukuda, Mark M. TI Plasmodium falciparum Gametocyte Carriage Is Associated with Subsequent Plasmodium vivax Relapse after Treatment SO PLOS ONE LA English DT Article ID MALARIA; HUMANS; ANTIMALARIAL; INFECTIONS; THAILAND AB Mixed P. falciparum/P. vivax infections are common in southeast Asia. When patients with P. falciparum malaria are treated and followed for several weeks, a significant proportion will develop P. vivax malaria. In a combined analysis of 243 patients recruited to two malaria treatment trials in western Cambodia, 20/43 (47%) of those with P. falciparum gametocytes on admission developed P. vivax malaria by Day 28 of follow-up. The presence of Pf gametocytes on an initial blood smear was associated with a 3.5-fold greater rate of vivax parasitemia post-treatment (IRR = 3.5, 95% CI 2.0-6.0, p < 0.001). The increased rate of post-treatment P. vivax infection persisted when correlates of exposure and immunity such as a history of malaria, male gender, and age were controlled for (IRR = 3.0, 95% CI 1.9-4.7, p < 0.001). Polymerase chain reaction (PCR) confirmed that only a low proportion of subjects (5/55 or 9.1%) who developed vivax during follow-up had detectable Pv parasites in the peripheral blood at baseline. Molecular detection of falciparum gametocytes by reverse transcriptase PCR in a subset of patients strengthened the observed association, while PCR detection of Pv parasitemia at follow-up was similar to microscopy results. These findings suggest that the majority of vivax infections arising after treatment of falciparum malaria originate from relapsing liver-stage parasites. In settings such as western Cambodia, the presence of both sexual and asexual forms of P. falciparum on blood smear at presentation with acute falciparum malaria serves as a marker for possible occult P. vivax coinfection and subsequent relapse. These patients may benefit from empiric treatment with an 8-aminoquinolone such as primaquine. C1 [Lin, Jessica T.; Bethell, Delia; Tyner, Stuart D.; Lon, Chanthap; Saunders, David L.; Sriwichai, Sabaithip; Khemawoot, Phisit; Kuntawunggin, Worachet; Smith, Bryan L.; Schaecher, Kurt; Se, Youry; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Noedl, Harald] Med Univ Vienna, Dept Specif Prophylaxis & Trop Med, Vienna, Austria. [Shah, Naman K.; Meshnick, Steven R.] Univ N Carolina, Dept Epidemiol, Gillings Sch Publ Hlth, Chapel Hill, NC USA. [Lin, Jessica T.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [Fukuda, Mark M.] Armed Forces Hlth Surveillance Ctr, Div Global Emerging Infect Dis Operat, Silver Spring, MD USA. RP Lin, JT (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM jesstlin@gmail.com RI Valle, Ruben/A-7512-2013 FU U.S. Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS); American Society of Tropical Medicine and Hygiene FX This study was funded by the U.S. Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS) Program (for funding of the clinical trial) and a Pfizer Centennial Travel Award sponsored by the American Society of Tropical Medicine and Hygiene granted to Dr. Lin. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 7 Z9 8 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 20 PY 2011 VL 6 IS 4 AR e18716 DI 10.1371/journal.pone.0018716 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 752UE UT WOS:000289719400021 PM 21533092 ER PT J AU Eller, MA Blom, KG Gonzalez, VD Eller, LA Naluyima, P Laeyendecker, O Quinn, TC Kiwanuka, N Serwadda, D Sewankambo, NK Tasseneetrithep, B Wawer, MJ Gray, RH Marovich, MA Michael, NL de Souza, MS Wabwire-Mangen, F Robb, ML Currier, JR Sandberg, JK AF Eller, Michael A. Blom, Kim G. Gonzalez, Veronica D. Eller, Leigh Anne Naluyima, Prossy Laeyendecker, Oliver Quinn, Thomas C. Kiwanuka, Noah Serwadda, David Sewankambo, Nelson K. Tasseneetrithep, Boonrat Wawer, Maria J. Gray, Ronald H. Marovich, Mary A. Michael, Nelson L. de Souza, Mark S. Wabwire-Mangen, Fred Robb, Merlin L. Currier, Jeffrey R. Sandberg, Johan K. TI Innate and Adaptive Immune Responses Both Contribute to Pathological CD4 T Cell Activation in HIV-1 Infected Ugandans SO PLOS ONE LA English DT Article ID HIV-INFECTED INDIVIDUALS; AFRICAN-GREEN MONKEYS; MICROBIAL TRANSLOCATION; VIRAL LOAD; DISEASE PROGRESSION; PERIPHERAL-BLOOD; LYMPHOCYTE-ACTIVATION; VIRUS-INFECTIONS; PD-1 EXPRESSION; RAKAI DISTRICT AB HIV-1 disease progression is associated with persistent immune activation. However, the nature of this association is incompletely understood. Here, we investigated immune activation in the CD4 T cell compartment of chronically HIV-1 infected individuals from Rakai, Uganda. Levels of CD4 T cell activation, assessed as co-expression of PD-1, CD38 and HLA-DR, correlated directly to viral load and inversely to CD4 count. Deeper characterization of these cells indicated an effector memory phenotype with relatively frequent expression of Ki67 despite their PD-1 expression, and levels of these cells were inversely associated with FoxP3+ regulatory T cells. We therefore use the term deregulated effector memory (DEM) cells to describe them. CD4 T cells with a DEM phenotype could be generated by antigen stimulation of recall responses in vitro. Responses against HIV-1 and CMV antigens were enriched among the DEM CD4 T cells in patients, and the diverse V beta repertoire of DEM CD4 T cells suggested they include diverse antigen-specificities. Furthermore, the levels of DEM CD4 T cells correlated directly to soluble CD14 (sCD14) and IL-6, markers of innate immune activation, in plasma. The size of the activated DEM CD4 T cell subset was predictive of the rate of disease progression, whereas IL-6 was only weakly predictive and sCD14 was not predictive. Taken together, these results are consistent with a model where systemic innate immune activation and chronic antigen stimulation of adaptive T cell responses both play important roles in driving pathological CD4 T cell immune activation in HIV-1 disease. C1 [Eller, Michael A.; Eller, Leigh Anne; Naluyima, Prossy; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Eller, Michael A.; Eller, Leigh Anne; Tasseneetrithep, Boonrat; Marovich, Mary A.; Michael, Nelson L.; de Souza, Mark S.; Robb, Merlin L.; Currier, Jeffrey R.] US Mil HIV Res Program, Rockville, MD USA. [Eller, Michael A.; Blom, Kim G.; Gonzalez, Veronica D.; Sandberg, Johan K.] Karolinska Inst, Ctr Infect Med, Dept Med, Karolinska Univ Hosp Huddinge, Stockholm, Sweden. [Laeyendecker, Oliver; Quinn, Thomas C.] NIAID, NIH, Bethesda, MD 20892 USA. [Laeyendecker, Oliver; Quinn, Thomas C.] Johns Hopkins Sch Med, Baltimore, MD USA. [Kiwanuka, Noah; Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Coll Hlth Sci, Kampala, Uganda. [Kiwanuka, Noah; Serwadda, David; Sewankambo, Nelson K.; Wawer, Maria J.; Gray, Ronald H.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda. [Sewankambo, Nelson K.] Makerere Univ, Fac Med, Coll Hlth Sci, Kampala, Uganda. [Tasseneetrithep, Boonrat] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. [Wawer, Maria J.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Gray, Ronald H.] Johns Hopkins Ctr Global Hlth, Baltimore, MD USA. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Eller, MA (reprint author), Makerere Univ, Walter Reed Project, Kampala, Uganda. EM johan.sandberg@ki.se RI Laeyendecker, Oliver/B-9331-2009; OI Sewankambo, Nelson/0000-0001-9362-053X; Laeyendecker, Oliver/0000-0002-6429-4760; Sandberg, Johan/0000-0002-6275-0750 FU National Institute of Allergy and Infectious Diseases (NIAID) [R01 A134826, R01 A134265]; National Institute of Child and Health Development [5P30HD06826]; Fogarty Foundation [5D43TW00010]; NIH [R01 A134826] FX Primary support was provided by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U. S. Department of Defense. Data collection was supported, in part, by grants R01 A134826 and R01 A134265 from the National Institute of Allergy and Infectious Diseases (NIAID); grant 5P30HD06826 from the National Institute of Child and Health Development; grant 5D43TW00010 from the Fogarty Foundation and NIH grant R01 A134826. Additional support was provided by the Swedish Research Council, the Swedish Cancer Foundation, the Stockholm County Council, Karolinska Institutet, and the Division of Intramural Research, NIAID, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 25 Z9 25 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 19 PY 2011 VL 6 IS 4 AR e18779 DI 10.1371/journal.pone.0018779 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 752EC UT WOS:000289671100021 PM 21526194 ER PT J AU Khedir, KR Kannarpady, GK Ishihara, H Woo, J Ryerson, C Biris, AS AF Khedir, Khedir R. Kannarpady, Ganesh K. Ishihara, Hidetaka Woo, Justin Ryerson, Charles Biris, Alexandru S. TI Design and Fabrication of Teflon-Coated Tungsten Nanorods for Tunable Hydrophobicity SO LANGMUIR LA English DT Article ID SUPERHYDROPHOBIC SURFACES; CONTACT ANGLES; ROUGH SURFACES; WATER; NANOSTRUCTURES; WETTABILITY; DEPOSITION; TRANSITION; ALUMINUM; STATE AB The nature of water interaction with tungsten nanorods (WNRs) fabricated by the glancing-angle deposition technique (GLAD)-using RF magnetron sputtering under various Ar pressures and substrate tilting angles and then subsequent coating with Teflon-has been studied and reported. Such nanostructured surfaces have shown strong water repellency properties with apparent water contact angles (AWCA) of as high as 160, which were found to depend I strongly upon the fabrication conditions. Variations in Ar pressure and the substrate tilting angle resulted in the generation of WNRs with different surface roughness and porosity properties. A theoretical model has been proposed to predict the observed high AWCAs measured at the nanostructure interfaces. The unique pyramidal tip geometry of WNRs generated at low Ar pressure with a high oblique angle reduced the solid fraction at the water interface, explaining the high AWCA measured on such surfaces. It was also found that the top geometrical morphologies controlling the total solid fraction of the WNRs are dependent upon and controlled by both the Ar pressure and substrate tilting angle. The water repellency of the tungsten nanorods with contact angles as high as 160 suggests that these coatings have enormous potential for robust: superhydrophobic and anti-icing applications in harsh environments. C1 [Khedir, Khedir R.; Kannarpady, Ganesh K.; Ishihara, Hidetaka; Woo, Justin; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Ryerson, Charles] Ctr US Army Corps Engineers, Cold Reg Res & Engn Lab Engineer Res & Dev, Terr & Cryospher Sci Branch, Hanover, NH 03755 USA. RP Kannarpady, GK (reprint author), Univ Arkansas, Nanotechnol Ctr, 2801 S Univ Ave, Little Rock, AR 72204 USA. EM gkkannarpady@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU U.S. Army [W912HZ-09-02-0008]; Arkansas Science & Technology Authority [08-CAT-03]; Department of Energy [DE-FG36-06GO86072]; National Science Foundation [NSF/EPS-1003970] FX Financial support from the U.S. Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008), the Arkansas Science & Technology Authority (Grant # 08-CAT-03), and the Department of Energy (DE-FG36-06GO86072) and National Science Foundation (NSF/EPS-1003970) is greatly appreciated. The editorial assistance of Dr. Marinelle Ringer is also acknowledged. NR 29 TC 18 Z9 18 U1 0 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD APR 19 PY 2011 VL 27 IS 8 BP 4661 EP 4668 DI 10.1021/la104891u PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 747LJ UT WOS:000289321000052 PM 21405046 ER PT J AU Spadafora, C Gerena, L Kopydlowski, KM AF Spadafora, Carmenza Gerena, Lucia Kopydlowski, Karen M. TI Comparison of the in vitro invasive capabilities of Plasmodium falciparum schizonts isolated by Percoll gradient or using magnetic based separation SO MALARIA JOURNAL LA English DT Article ID ERYTHROCYTES; CULTURE; PARASITES; SYNCHRONIZATION; INVITRO; MALARIA; BLOOD; CELLS AB Background: Percoll gradient centrifugation is often used for synchronization, enrichment, or isolation of a particular stage of Plasmodium falciparum. However, Percoll, a hyperosmotic agent, may have harmful effects on the parasites. Magnetic bead column (MBC) separation has been used as an alternative. This is a report of a head-to-head comparison of the in vitro invasive capabilities of parasites isolated by either of the two methods. Methods: The P. falciparum laboratory strain isolate 7G8 was grown in vitro using standard procedures and synchronized using 5% sorbitol. On separate days when the schizont parasitaemia was > 1%, the culture was split and half was processed by Percoll gradient centrifugation and the other half by magnetic bead column separation. Both processed parasites were placed back in culture and allowed to invade new uninfected erythrocytes. Results: In 10 paired assays, the mean efficiency of invasion of 7G8 parasites treated by Percoll gradient centrifugation was 35.8% that of those treated by magnetic bead column separation (95% Cl, p = 0.00067) A paired t test with two tails was used for these comparisons. Conclusions: In this comparison, magnetic bead column separation of 7G8 schizonts resulted in higher viability and efficiency of invasion than utilizing Percoll gradient centrifugation. C1 [Spadafora, Carmenza] Walter Reed Army Inst Res, Cellular Injury Dept, Div Mil Casualty Res, Silver Spring, MD 20902 USA. [Kopydlowski, Karen M.] US Army Med Mat Dev Act, Ft Detrick, MD 21702 USA. [Gerena, Lucia; Kopydlowski, Karen M.] Walter Reed Army Inst Res, Dept Parasitol, Div Expt Therapeut, Silver Spring, MD 20902 USA. [Spadafora, Carmenza] Inst Invest Cient & Serv Alta Tecnol AIP, Ctr Biol Celular & Mol Enfermedades, Ciudad Del Saber, Clayton, Panama. RP Spadafora, C (reprint author), Walter Reed Army Inst Res, Cellular Injury Dept, Div Mil Casualty Res, 503 Robert Grant Ave, Silver Spring, MD 20902 USA. EM cspadafora@indicasat.org.pa OI Spadafora, Carmenza/0000-0002-3002-9467 FU USAMRMC (U.S. Army Medical Research and Materiel Command); Fogarty International Center [1 D43 TW06239]; Uniformed Services University of Health Sciences, Bethesda, MD; Secretaria Nacional de Ciencia y Tecnologia (SENACYT), Republica de Panama FX The authors would like to thank Christian Darko (Naval Medical Research Center) for introducing us to the use of magnetic columns. Sheila Peel (The Walter Reed Army Institute of Research, HIV Program) gave very helpful advice on the culture of the parasites and analysis of the data. KMK and LG were supported by the USAMRMC (U.S. Army Medical Research and Materiel Command) Military Infectious Diseases Research Program. CS was supported in part by a training grant from the Fogarty International Center (1 D43 TW06239, PI Jose A. Stoute), by intramural funds from the Uniformed Services University of Health Sciences, Bethesda, MD, and a training grant from the Secretaria Nacional de Ciencia y Tecnologia (SENACYT), Republica de Panama. The opinions expressed herein are those of the authors and do not reflect the views or opinions of the U. S. Army and the Department of Defense. NR 16 TC 9 Z9 10 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 18 PY 2011 VL 10 AR 96 DI 10.1186/1475-2875-10-96 PG 4 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 767NJ UT WOS:000290863000001 PM 21501476 ER PT J AU Knox, JB Dai, JM Orchowski, J AF Knox, Jeffrey B. Dai, Joseph M., III Orchowski, Joseph TI Osteolysis in Transforaminal Lumbar Interbody Fusion with Bone Morphogenetic Protein-2 SO SPINE LA English DT Article DE osteolysis; BMP; interbody fusion; complication; osteobiologics ID POSTERIOR ILIAC CREST; PROTEIN-2/COMPRESSION RESISTANT MATRIX; GRADE-ISTHMIC-SPONDYLOLISTHESIS; CLINICAL-OUTCOMES; SPINAL-FUSION; HARVEST-SITE; RHBMP-2; COMPLICATIONS; GRAFT; ANTERIOR AB Study Design. Retrospective radiographic review. Objective. To determine the incidence of osteolysis, graft subsidence, and cage migration after recombinant human bone morphogenetic protein-2 (rhBMP-2) use with transforaminal lumbar interbody fusion (TLIF). Summary of Background Data. Osteolysis after TLIF is a recently described phenomenon associated with rhBMP-2 use. Although this is typically a self-limiting condition, complications such as graft subsidence and cage migration have been described. The incidence of this is not well defined and most studies use plain radiographs for diagnosis rather than more advanced imaging. This study serves to quantify the risk of osteolysis and its associated graft complications with routine use of computed tomography. Methods. A total of 58 patients who underwent primary TLIF from a single surgeon between 2004 and 2007 underwent routine postoperative computed tomographic scan. Seventy-seven levels of fusion were evaluated for osteolysis. All patients received the same dose of rhBMP-2 of 5 mg per level. Imaging was performed immediately postoperative and again at an average of 4.3 months postoperative (range = 2.4-9.0 months). These images were evaluated for the presence of osteolysis, graft subsidence, and cage migration. These changes were then graded according to their severity. Results. Osteolysis was found in 16 of the 58 (27.6%) patients and 19 of the 77 (24.7%) levels treated. No significant difference was found between single and two-level fusions. The degree of osteolysis ranged from 3 to 20 mm with an average of 12.5 mm. The osteolysis was characterized as severe (> 1 cm) in 12 of the 19 levels. Of the patients with osteolysis, 31.6% demonstrated graft subsidence all of which occurred with severe osteolytic defects. Migration of the intervertebral cage was found in 8.8% of patients. Conclusion. rhBMP-2 use with TLIF is associated with a significant risk of postoperative osteolysis. Patients who demonstrated postoperative osteolysis were associated with significant risk of subsidence or migration of the intervertebral cage. The clinical implications of these changes are not currently known. C1 [Knox, Jeffrey B.; Dai, Joseph M., III; Orchowski, Joseph] Tripler Army Med Ctr, Orthoped Surg Serv, Dept Surg, Honolulu, HI 96859 USA. RP Knox, JB (reprint author), Tripler Army Med Ctr, Dept Orthoped Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.bruce.knox@us.army.mil NR 36 TC 31 Z9 31 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD APR 15 PY 2011 VL 36 IS 8 BP 672 EP 676 DI 10.1097/BRS.0b013e3181e030e0 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 746AB UT WOS:000289211900022 PM 21217443 ER PT J AU Bever, AJ McNinch, JE Harris, CK AF Bever, Aaron J. McNinch, Jesse E. Harris, Courtney K. TI Hydrodynamics and sediment-transport in the nearshore of Poverty Bay, New Zealand: Observations of nearshore sediment segregation and oceanic storms SO CONTINENTAL SHELF RESEARCH LA English DT Article DE Sediment-transport; Small mountainous river; Oceanic storm; Sediment segregation; Waipaoa River ID CALIFORNIA CONTINENTAL-SHELF; AMAZON SUBAQUEOUS DELTA; BOTTOM BOUNDARY-LAYER; NORTHERN CALIFORNIA; INNER SHELF; EEL RIVER; GRAVITY FLOWS; WAIAPU RIVER; WAVE; ESTUARY AB Nearshore regions act as an interface between the terrestrial environment and deeper waters. As such, they play important roles in the dispersal of fluvial sediment and the transport of sand to and from the shoreline. This study focused on the nearshore of Poverty Bay, New Zealand, and the processes controlling the dispersal of sediment from the main source, the Waipaoa River. Hydrodynamics and sediment-transport in water shallower than 15 m were observed from April through mid-September 2006. This deployment afforded observations during 3-4 periods of elevated river discharge and 5 dry storms. Similar wind, river discharge, wave, current, and turbidity patterns were characterized during three of the wet storms. At the beginning of each event, winds blew shoreward, increasing wave heights to 2-3 m within Poverty Bay. As the cyclonic storms moved through the system the winds reversed direction and became seaward, reducing the local wave height and orbital velocity while river discharge remained elevated. At these times, high river discharge and relatively small waves enabled fluvially derived suspended sediment to deposit in shallow water. Altimetry measurements indicated that at least 7 cm was deposited at a 15 m deep site during a single discharge event. Turbidity and seabed observations showed this deposition to be removed, however, as large swell waves from the Southern Ocean triggered resuspension of the material within three weeks of deposition. Consequently, two periods of dispersal were associated with each discharge pulse, one coinciding with fluvial delivery, and a second driven by wave resuspension a few weeks later. These observations of nearfield sediment deposition contradict current hypotheses of very limited sediment deposition in shallow water offshore of small mountainous rivers when floods and high-energy, large wave and fast current, oceanic conditions coincide. Consistently shoreward near-bed currents, observed along the 10 m isobath of Poverty Bay, were attributed to a combination of estuarine circulation, Stokes drift, and wind driven upwelling. Velocities measured at the 15 m isobath, however, were directed more alongshore and diverged from those at the 10 m isobath. The divergence in the currents observed at the 10 and 15 m locations seemed to facilitate segregation of coarse and fine sediment, with sand transported near-bed toward the beach, while suspended silts and clays were exported to deeper water. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Bever, Aaron J.; Harris, Courtney K.] Coll William & Mary, Virginia Inst Marine Sci, Gloucester Point, VA 23062 USA. [McNinch, Jesse E.] Army Corps Engineers Field Res Facil, Duck, NC USA. RP Bever, AJ (reprint author), Coll William & Mary, Virginia Inst Marine Sci, 1208 Greate Rd, Gloucester Point, VA 23062 USA. EM abever@vims.edu; Jesse.Mcninch@usace.army.mil; ckharris@vims.edu OI Bever, Aaron/0000-0002-2196-0831 FU MARGINS Source-to-Sink initiative [OCE-0841049, OCE-0504690] FX The authors thank Heidi Wadman (now ACOE), Bob Gammisch (VIMS), Wayne Reisner (VIMS), Neil Hein (NIWA), and NIWA Hamilton for their help in the field deployments. Two anonymous reviewers helped to significantly improve this manuscript. We also thank Carl Friedrichs and Art Trembanis for discussions and help in analyzing ADV turbulence measurements. This work was funded under the MARGINS Source-to-Sink initiative, programs OCE-0841049 and OCE-0504690 and is contribution number 3218 from the Virginia Institute of Marine Science, The College of William & Mary. NR 78 TC 18 Z9 18 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-4343 J9 CONT SHELF RES JI Cont. Shelf Res. PD APR 15 PY 2011 VL 31 IS 6 BP 507 EP 526 DI 10.1016/j.csr.2010.12.007 PG 20 WC Oceanography SC Oceanography GA 765ZE UT WOS:000290747100001 ER PT J AU Liston, GE Hemstra, CA AF Liston, Glen E. Hemstra, Christopher A. TI Representing Grass- and Shrub-Snow-Atmosphere Interactions in Climate System Models SO JOURNAL OF CLIMATE LA English DT Article ID DATA ASSIMILATION SYSTEM; ANTARCTIC ICE-SHEET; SAGEBRUSH-STEPPE; ARCTIC TUNDRA; MOISTURE FLUXES; AIR-TEMPERATURE; TRANSPORT MODEL; LOCAL ANALYSIS; UPPER TREELINE; SEASONAL SNOW AB A vegetation-protruding-above-snow parameterization for earth system models was developed to improve energy budget calculations of interactions among vegetation, snow, and the atmosphere in nonforested areas. These areas include shrublands, grasslands, and croplands, which represent 68% of the seasonally snow-covered Northern Hemisphere land surface (excluding Greenland). Snow depth observations throughout nonforested areas suggest that mid- to late-winter snowpack depths are often comparable or lower than the vegetation heights. As a consequence, vegetation protruding above the snow cover has an important impact on mow-season surface energy budgets. The protruding vegetation parameterization uses disparate energy balances for snow-covered and protruding vegetation fractions of each model grid cell, and fractionally weights these fluxes to define grid-average quantities. Snow Model, a spatially distributed snow-evolution modeling system, was used to test and assess the parameterization. Simulations were conducted during the winters of 2005/06 and 2006/07 for conditions of 1) no protruding vegetation (the control) and 2) with protruding vegetation. The spatial domain covered Colorado, Wyoming, and portions of the surrounding states; 81% of this area is nonforested. The surface net radiation, energy, and moisture fluxes displayed considerable differences when protruding vegetation was included. For shrubs, the net radiation, sensible, and latent fluxes changed by an average of 12.7, 6.9, and -22.7 W m(-2), respectively. For grass and crops, these fluxes changed by an average of 6.9, -0.8, and -7.9 W m(-2), respectively. Daily averaged flux changes were as much as 5 times these seasonal averages. As such, the new parameterization represents a major change in surface flux calculations over more simplistic and less physically realistic approaches. C1 [Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Hemstra, Christopher A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Liston, GE (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. EM liston@cira.colostate.edu FU NASA [NNG04GP59G, NNX08AI03G] FX The authors thank Dan Birkenheuer for kindly providing the LAPS datasets. This work was supported by NASA Grants NNG04GP59G and NNX08AI03G. NR 107 TC 6 Z9 7 U1 1 U2 10 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8755 J9 J CLIMATE JI J. Clim. PD APR 15 PY 2011 VL 24 IS 8 BP 2061 EP 2079 DI 10.1175/2010JCLI4028.1 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 756GX UT WOS:000290000800003 ER PT J AU Clayton, JD Knap, J AF Clayton, J. D. Knap, J. TI A phase field model of deformation twinning: Nonlinear theory and numerical simulations SO PHYSICA D-NONLINEAR PHENOMENA LA English DT Article DE Phase field; Nonlinear elasticity; Energy minimization; Twinning; Crystals; Magnesium ID COMPUTER-SIMULATION; ELASTIC STRAIN; HCP METALS; CRYSTALS; DISLOCATION; NUCLEATION; MAGNESIUM; DYNAMICS; SLIP; TRANSFORMATION AB A continuum phase field theory and corresponding numerical solution methods are developed to describe deformation twinning in crystalline solids. An order parameter is associated with the magnitude of twinning shear, i.e., the lattice transformation associated with twinning. The general theory addresses the following physics: large deformations, nonlinear anisotropic elastic behavior, and anisotropic phase boundary energy. The theory is applied towards prediction of equilibrium phenomena in the athermal and non-dissipative limit, whereby equilibrium configurations of an externally stressed crystal are obtained via incremental minimization of a free energy functional. Outcomes of such calculations are elastic fields (e.g., displacement, strain, stress, and strain energy density) and the order parameter field that describes the size and shape of energetically stable twin(s). Numerical simulations of homogeneous twin nucleation in magnesium single crystals demonstrate fair agreement between phase field solutions and available analytical elasticity solutions. Results suggest that critical far-field displacement gradients associated with nucleation of a twin embryo of minimum realistic size are 4.5%-5.0%, with particular values of applied shear strain and equilibrium shapes of the twin somewhat sensitive to far-field boundary conditions and anisotropy of twin boundary surface energy. Published by Elsevier R.V. C1 [Clayton, J. D.] USA, High Rate Mech & Failure Branch, RDRL WMP B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Knap, J.] USA, Computat Sci & Engn Branch, RDRL CIH C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, High Rate Mech & Failure Branch, RDRL WMP B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1@us.army.mil RI Clayton, John/C-7760-2009 NR 49 TC 43 Z9 44 U1 4 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 EI 1872-8022 J9 PHYSICA D JI Physica D PD APR 15 PY 2011 VL 240 IS 9-10 BP 841 EP 858 DI 10.1016/j.physd.2010.12.012 PG 18 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 748OB UT WOS:000289398800004 ER PT J AU Raghuveer, TS Cox, AJ AF Raghuveer, Talkad S. Cox, Austin J. TI Neonatal Resuscitation: An Update SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID EMERGENCY CARDIOVASCULAR CARE; RANDOMIZED CONTROLLED-TRIAL; DELIVERY-ROOM; 100-PERCENT OXYGEN; NEWBORN-INFANTS; CARDIOPULMONARY-RESUSCITATION; TREATMENT RECOMMENDATIONS; PRETERM INFANTS; CARDIAC-ARREST; TERM INFANTS AB Appropriate resuscitation must be available for each of the more than 4 million infants born annually in the United States. Ninety percent of infants transition safely, and it is up to the physician to assess risk factors, identify the nearly 10 percent of infants who need resuscitation, and respond appropriately. A team or persons trained in neonatal resuscitation should be promptly available to provide resuscitation. The Neonatal Resuscitation Program, which was initiated in 1987 to identify infants at risk of needing resuscitation and provide high-quality resuscitation, underwent major updates in 2006 and 2010. Among the most important changes are to not intervene with endotracheal suctioning in vigorous infants born through meconium-stained amniotic fluid (although endotracheal suctioning may be appropriate in nonvigorous infants); to provide positive pressure ventilation with one of three devices when necessary; to begin resuscitation of term infants using room air or blended oxygen; and to have a pulse oximeter readily available in the delivery room. The updated guidelines also provide indications for chest compressions and for the use of intravenous epinephrine, which is the preferred route of administration, and recommend not to use sodium bicarbonate or naloxone during resuscitation. Other recommendations include confirming endotracheal tube placement using an exhaled carbon dioxide detector; using less than 100 percent oxygen and adequate thermal support to resuscitate preterm infants; and using therapeutic hypothermia for infants born at 36 weeks' gestation or later with moderate to severe hypoxic-ischemic encephalopathy. (Am Fam Physician. 2011;83(8):911-918. Copyright (c) 2011 American Academy of Family Physicians.) C1 [Raghuveer, Talkad S.] Wesley Med Ctr, Dept Neonatol, Wichita, KS 67214 USA. [Raghuveer, Talkad S.] Pediatrix Med Grp Kansas, Wichita, KS USA. [Cox, Austin J.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Raghuveer, TS (reprint author), Wesley Med Ctr, Dept Neonatol, 550 N Hillside, Wichita, KS 67214 USA. EM raghuveer.talkad3@gmail.com NR 51 TC 6 Z9 6 U1 1 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 15 PY 2011 VL 83 IS 8 BP 911 EP 918 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 979ZP UT WOS:000306863700005 PM 21524031 ER PT J AU Ahmed, M Tan, SH Sun, C Shaheduzzaman, S Hu, Y Petrovics, G Chen, YM Li, H Sesterhenn, I Sreenath, T McLeod, DG Dobi, A Srivastava, S AF Ahmed, Mohamed Tan, Shyh-Han Sun, Chen Shaheduzzaman, Syed Hu, Ying Petrovics, Gyorgy Chen, Yongmei Li, Hua Sesterhenn, Isabel Sreenath, Taduru McLeod, David G. Dobi, Albert Srivastava, Shiv TI Defining the role of ERG-mediated repression of HPGD in prostate tumorigenesis SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ahmed, Mohamed; Tan, Shyh-Han; Sun, Chen; Shaheduzzaman, Syed; Hu, Ying; Petrovics, Gyorgy; Chen, Yongmei; Li, Hua; Sreenath, Taduru; Dobi, Albert; Srivastava, Shiv] Henry M Jackson Fdn, Ctr Prostate Dis Res, Rockville, MD USA. [Sesterhenn, Isabel] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [McLeod, David G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 4007 DI 10.1158/1538-7445.AM2011-4007 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701404159 ER PT J AU Ellsworth, RE Field, LA Deyarmin, B Love, B Hooke, J Shriver, C AF Ellsworth, Rachel E. Field, Lori A. Deyarmin, Brenda Love, Brad Hooke, Jeffrey Shriver, Craig TI Identification of differentially expressed genes in breast tumors from African American compared with Caucasian women SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn, Windber, PA USA. [Field, Lori A.; Deyarmin, Brenda] Windber Res Inst, Windber, PA USA. [Love, Brad] BioReka, Lutherville Timonium, MD USA. [Hooke, Jeffrey; Shriver, Craig] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 3741 DI 10.1158/1538-7445.AM2011-3741 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701405448 ER PT J AU Levin, LI Breen, EC Kitchen, CR Kim, BK Magpantay, LI Martinez-Maza, O AF Levin, Lynn I. Breen, Elizabeth C. Kitchen, Christina R. Kim, Bong K. Magpantay, Larry I. Martinez-Maza, Otoniel TI Total IgE serum levels and risk of mature B cell non-Hodgkin lymphoma (NHL) SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Levin, Lynn I.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Breen, Elizabeth C.; Kitchen, Christina R.; Magpantay, Larry I.; Martinez-Maza, Otoniel] Univ Calif Los Angeles, Los Angeles, CA USA. [Kim, Bong K.] Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 4644 DI 10.1158/1538-7445.AM2011-4644 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701406062 ER PT J AU Peck, AR Witkiewicz, AK Liu, CB Stringer, GA Klimowicz, AC Pequignot, E Freydin, B Tran, TH Yang, N Rosenberg, AL Hooke, JA Kovatich, AJ Nevalainen, MT Shriver, CD Hyslop, T Sauter, G Rimm, DL Magliocco, AM Rui, H AF Peck, Amy R. Witkiewicz, Agnieszka K. Liu, Chengbao Stringer, Ginger A. Klimowicz, Alexander C. Pequignot, Edward Freydin, Boris Tran, Thai H. Yang, Ning Rosenberg, Anne L. Hooke, Jeffrey A. Kovatich, Albert J. Nevalainen, Marja T. Shriver, Craig D. Hyslop, Terry Sauter, Guido Rimm, David L. Magliocco, Anthony M. Rui, Hallgeir TI Loss of nuclear localized and tyrosine phosphorylated Stat5: A predictor of poor clinical outcome and increased risk of antiestrogen therapy failure in breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Peck, Amy R.; Witkiewicz, Agnieszka K.; Liu, Chengbao; Stringer, Ginger A.; Pequignot, Edward; Freydin, Boris; Tran, Thai H.; Yang, Ning; Rosenberg, Anne L.; Nevalainen, Marja T.; Hyslop, Terry; Rui, Hallgeir] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Klimowicz, Alexander C.; Magliocco, Anthony M.] Tom Baker Canc Clin, Calgary, AB, Canada. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kovatich, Albert J.] MDR Global Syst, Windber, PA USA. [Sauter, Guido] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. [Rimm, David L.] Yale Univ, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 2277 DI 10.1158/1538-7445.AM2011-2277 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701405338 ER PT J AU Sears, AK Clifton, GT Van Echo, DC Holmes, JP Zacharia, A Jama, Y Mursal, M Chiplis, A Mittendorf, EA Peoples, GE Ponniah, S AF Sears, Alan K. Clifton, Guy T. Van Echo, David C. Holmes, Jarrod P. Zacharia, Athina Jama, Yusuf Mursal, Mohamed Chiplis, Anna Mittendorf, Elizabeth A. Peoples, George E. Ponniah, Sathibalan TI Circulating regulatory T cells (CD4(+)CD25(high) CD127(low)) decrease in breast cancer patients after vaccination with a modified HER-2/neu HLA class II peptide (AE37) vaccine SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Sears, Alan K.; Clifton, Guy T.; Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Van Echo, David C.; Holmes, Jarrod P.; Zacharia, Athina; Jama, Yusuf; Mursal, Mohamed; Chiplis, Anna; Ponniah, Sathibalan] Canc Vaccine Dev Program, Bethesda, MD USA. [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA LB-413 DI 10.1158/1538-7445.AM2011-LB-413 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701404384 ER PT J AU Tsivin, V Halle, D Gure, AO Pavlov, V Roistacher, M Ilyiayev, N Mitrani-Rosenbaum, S Stojadinovic, A Trink, B Rubinstein, A Nissan, A AF Tsivin, Victoria Halle, David Gure, Ali O. Pavlov, Vera Roistacher, Marina Ilyiayev, Nadia Mitrani-Rosenbaum, Stella Stojadinovic, Alexander Trink, Barry Rubinstein, Abraham Nissan, Aviram TI The impact of siRNA targeting Colon Cancer Associated Transcript 1 (CCAT-1) on proliferation of HT-29 cells SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Tsivin, Victoria; Halle, David; Pavlov, Vera; Roistacher, Marina; Ilyiayev, Nadia; Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Surg Oncol Lab, Jerusalem, Israel. [Gure, Ali O.] Bilkent Univ, Dept Mol Biol & Genet, Ankara, Turkey. [Mitrani-Rosenbaum, Stella] Hadassah Hebrew Univ, Med Ctr Mt Scopus, Goldyne Savad Inst Gene Therapy, Jerusalem, Israel. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Trink, Barry] Johns Hopkins Sch Med, Baltimore, MD USA. [Rubinstein, Abraham] Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, Fac Med, IL-91120 Jerusalem, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 1172 DI 10.1158/1538-7445.AM2011-1172 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701404208 ER PT J AU Valente, AL Ellsworth, RE Lubert, S Holliday, C Shriver, CD AF Valente, Allyson L. Ellsworth, Rachel E. Lubert, Susan Holliday, Charvonne Shriver, Craig D. TI Identification of CDH1 mutations in patients with lobular carcinoma with and without a family history of gastric cancer SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Valente, Allyson L.; Lubert, Susan; Holliday, Charvonne] Windber Res Inst, Windber, PA USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2011 VL 71 SU 8 MA 2202 DI 10.1158/1538-7445.AM2011-2202 PG 1 WC Oncology SC Oncology GA V43SP UT WOS:000209701402299 ER PT J AU Ruge, DR Dunning, FM Piazza, TM Molles, BE Adler, M Zeytin, FN Tucker, WC AF Ruge, Daniel R. Dunning, F. Mark Piazza, Timothy M. Molles, Brian E. Adler, Michael Zeytin, Fuesun N. Tucker, Ward C. TI Detection of six serotypes of botulinum neurotoxin using fluorogenic reporters SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE Botulinum neurotoxin; Proteases; FRET; High-throughput assays ID A LIGHT-CHAIN; SUBSTRATE RECOGNITION; CLOSTRIDIUM-BOTULINUM; TETANUS TOXIN; IN-VITRO; NEUROTRANSMITTER RELEASE; SNARE MOTIF; INHIBITORS; ASSAYS; VAMP/SYNAPTOBREVIN AB Methods that do not require animal sacrifice to detect botulinum neurotoxins (BoNTs) are critical for BoNT antagonist discovery and the advancement of quantitative assays for biodefense and pharmaceutical applications. Here we describe the development and optimization of fluorogenic reporters that detect the proteolytic activity of BoNT/A, B, D, E, F, and G serotypes in real time with femtomolar to picomolar sensitivity. Notably, the reporters can detect femtomolar concentrations of BoNT/A in 4 h and BoNT/E in 20 h, sensitivity that equals that of animal-based methods. The reporters can be used to determine the specific activity of BoNT preparations with intra- and inter-assay coefficients of variation of approximately 10%. Finally, we find that the greater sensitivity of our reporters compared with those used in other commercially available assays makes the former attractive candidates for high-throughput screening of BoNT antagonists. (C) 2011 Elsevier Inc. All rights reserved. C1 [Ruge, Daniel R.; Dunning, F. Mark; Piazza, Timothy M.; Zeytin, Fuesun N.; Tucker, Ward C.] BioSentinel Pharmaceut, Madison, WI 53719 USA. [Piazza, Timothy M.] Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA. [Molles, Brian E.; Adler, Michael] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, APG EA, Aberdeen Proving Ground, MD 21010 USA. RP Tucker, WC (reprint author), BioSentinel Pharmaceut, Madison, WI 53719 USA. EM wtucker@biosentinelpharma.com FU Department of Defense [07-2-0045]; US Geological Survey (USGS)-National Wildlife Health Center; National Park Service FX The authors thank E.R. Chapman, M. Dong, W. Checovich, and D. Atapattu for valuable discussions and advice. This research was supported in part by a Department of Defense award (07-2-0045). T.M.P. is supported in part by the US Geological Survey (USGS)-National Wildlife Health Center and the National Park Service. The views, opinions, and findings presented here are those of the authors and should not be construed as official Department of the Army positions, policies, or decisions unless designated by other documentation. Citation of trade names in this article does not constitute official Department of the Army endorsement or approval of the use of such commercial items. NR 63 TC 29 Z9 30 U1 2 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD APR 15 PY 2011 VL 411 IS 2 BP 200 EP 209 DI 10.1016/j.ab.2011.01.002 PG 10 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 736UA UT WOS:000288519300005 PM 21216216 ER PT J AU Zhang, SS Xu, K Read, J AF Zhang, Sheng S. Xu, Kang Read, Jeffrey TI A non-aqueous electrolyte for the operation of Li/air battery in ambient environment SO JOURNAL OF POWER SOURCES LA English DT Article DE Tris(2,2,2-trifluoroethyl) phosphite; Tris(2,2,2-trifluoroethyl) phosphate; Non-aqueous electrolyte; Ionic conductivity; Viscosity; Li/air battery ID LI-ION BATTERIES; FLUORINATED ALKYL PHOSPHATES; LITHIUM/OXYGEN BATTERY; LITHIUM/AIR BATTERIES; FLAME RETARDANTS; AIR BATTERIES; PERFORMANCE; ADDITIVES; VISCOSITY; INTERFACE AB In this work we report a non-aqueous electrolyte that supports long-term operation of the Li/air battery in dry ambient environments based on a non-hydrolytic LiSO(3)CF(3) salt and a low volatility propylene carbonate (PC)/tris(2,2,2-trifluoroethyl) phosphate (TFP) solvent blend. By measuring and analyzing the viscosity of PC/TFP solvent blends, the ionic conductivity of electrolytes, and the discharge performance of Li/air cells as a function of the PC/TFP weight ratio, we determined the best composition of the electrolyte is 0.2 m (molality) LiSO(3)CF(3) 7:3 wt. PC/TFP for Li/O(2) cells and 0.2 m LiSO(3)CF(3) 3:2 wt. PC/TFP for Li/air cells. Discharge results indicate that Li/air cells with the optimized electrolyte are significantly superior in specific capacity and rate capability to those with baseline electrolytes. More interestingly, the improvement in discharge performance becomes more significant as the discharge current increases or the oxygen partial pressure decreases. These results agree neither with the viscosity of the solvent blends nor the ionic conductivity of the electrolytes. We consider that the most likely reason for the performance improvement is due to the increased dissolution kinetics and solubility of oxygen in TFP-containing electrolytes. In addition, the electrolyte has a 5.15 V electrochemical window, which is suitable for use in rechargeable Li/air batteries. Published by Elsevier B.V. C1 [Zhang, Sheng S.] USA, Res Lab, RDRL SED C, Electrochem Branch,Sensors & Electron Devices Dir, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Electrochem Branch,Sensors & Electron Devices Dir, Adelphi, MD 20783 USA. EM shengshui.zhang@us.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 24 TC 52 Z9 55 U1 6 U2 83 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 15 PY 2011 VL 196 IS 8 SI SI BP 3906 EP 3910 DI 10.1016/j.jpowsour.2010.12.092 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 734RS UT WOS:000288355100031 ER PT J AU Geis, S Maboko, L Saathoff, E Hoffmann, O Geldmacher, C Mmbando, D Samky, E Michael, NL Birx, DL Robb, ML Hoelscher, M AF Geis, Steffen Maboko, Leonard Saathoff, Elmar Hoffmann, Oliver Geldmacher, Christof Mmbando, Donan Samky, Eleuter Michael, Nelson L. Birx, Deborah L. Robb, Merlin L. Hoelscher, Michael TI Risk Factors for HIV-1 Infection in a Longitudinal, Prospective Cohort of Adults From the Mbeya Region, Tanzania SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV-1; incidence; risk factors; cohort study; Tanzania; Africa ID ALCOHOL-USE; EDUCATIONAL-ATTAINMENT; MALE CIRCUMCISION; RURAL UGANDA; SOUTH-AFRICA; PREVALENCE; TRENDS; WOMEN; POPULATION; RAKAI AB Background: To control the global HIV epidemic, targeted interventions to reduce the incidence of HIV infections are urgently needed until an effective HIV vaccine is available. This study describes HIV-1 incidence and associated risk factors in a general population cohort of adults from Mbeya region, Tanzania, who participated in a vaccine preparedness study. Methods: We conducted a closed prospective cohort study with 6-monthly follow-up from 2002 to 2006 enrolling adults from the general population. HIV-1 incidence and risk factors for HIV-1 acquisition were analyzed using Cox regression. Results: We observed 2578 seronegative participants for a mean period of 3.06 person years (PY) (7471 PY in total). Overall HIV-1 incidence was 1.35 per 100 PY (95% confidence interval [CI], 1.10-1.64/100 PY). The highest overall HIV-1 incidence was found in females from Itende village (1.55 per 100 PY; 95% CI, 0.99-2.30/100 PY); the highest age-specific incidence was observed in semiurban males aged 30 to 34 years (2.75 per 100 PY; 95% CI, 0.75-7.04). HIV-1 acquisition was independently associated with female gender (hazard ratio [HR], 1.64; 95% CI, 1.05-2.57), younger age at enrollment (age 18-19 versus 35-39 years: HR, 0.29; 95% CI, 0.11-0.75), alcohol consumption (almost daily versus none: HR, 2.01; 95% CI, 1.00-4.07), education level (secondary school versus none: HR, 0.39; 95% CI, 0.17-0.89), and number of lifetime sex partners (more than five versus one: HR, 2.22; 95% CI, 1.13-4.36). Conclusions: A high incidence of HIV was observed in this cohort, and incident infection was strongly associated with young age, alcohol consumption, low school education level, and number of sex partners. Targeted interventions are needed to address the elevated risk associated with these factors. C1 [Geis, Steffen; Saathoff, Elmar; Hoffmann, Oliver; Geldmacher, Christof; Hoelscher, Michael] Univ Munich LMU, Div Infect Dis & Trop Med, Med Ctr, D-80802 Munich, Germany. [Geis, Steffen; Maboko, Leonard; Hoffmann, Oliver; Geldmacher, Christof; Hoelscher, Michael] NIMR Mbeya Med Res Programme, Mbeya, Tanzania. [Mmbando, Donan] Mbeya Reg Med Off, Mbeya, Tanzania. [Samky, Eleuter] Mbeya Referral Hosp, Mbeya, Tanzania. [Michael, Nelson L.] US Mil HIV Res Program MHPP, Rockville, MD USA. [Michael, Nelson L.] Walter Reed Army Inst Res, Rockville, MD USA. [Birx, Deborah L.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. RP Geis, S (reprint author), Univ Munich LMU, Div Infect Dis & Trop Med, Med Ctr, Leopoldstr 5, D-80802 Munich, Germany. EM steffen.geis@yahoo.de RI Hoelscher, Michael/D-3436-2012 FU Henry M. Jackson Foundation for the Advancement of Military Medicine; US Department of Defense [DAMD17-98-2-7007]; National Institute for Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-2642-11] FX The CODE study was supported by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense under DAMD17-98-2-7007 and by the National Institute for Allergy and Infectious Diseases, National Institutes of Health ("HIV Vaccine Research and Development-Project 2'' Y1-AI-2642-11). NR 36 TC 11 Z9 11 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 15 PY 2011 VL 56 IS 5 BP 453 EP 459 DI 10.1097/QAI.0b013e3182118fa3 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 733DP UT WOS:000288241800016 PM 21297483 ER PT J AU Pethel, SD Blakely, JN AF Pethel, Shawn D. Blakely, Jonathan N. TI Paucity of attractors in nonlinear systems driven with complex signals SO PHYSICAL REVIEW E LA English DT Article ID MULTISTABILITY; BIFURCATION; INTERVAL; LASER; MAPS AB We study the probability of multistability in a quadratic map driven repeatedly by a random signal of length N, where N is taken as a measure of the signal complexity. We first establish analytically that the number of coexisting attractors is bounded above by N. We then numerically estimate the probability p of a randomly chosen signal resulting in a multistable response as a function of N. Interestingly, with increasing drive signal complexity the system exhibits a paucity of attractors. That is, almost any drive signal beyond a certain complexity level will result in a single attractor response (p = 0). This mechanism may play a role in allowing sensitive multistable systems to respond consistently to external influences. C1 [Pethel, Shawn D.; Blakely, Jonathan N.] USA, RDECOM, RDMR WS, Redstone Arsenal, AL 35898 USA. RP Pethel, SD (reprint author), USA, RDECOM, RDMR WS, Redstone Arsenal, AL 35898 USA. OI Blakely, Jonathan/0000-0002-9772-582X NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD APR 12 PY 2011 VL 83 IS 4 AR 046205 DI 10.1103/PhysRevE.83.046205 PN 2 PG 4 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 750CT UT WOS:000289522600001 PM 21599268 ER PT J AU Chua, SL Caccamise, CA Phillips, DJ Joannopoulos, JD Soljacic, M Everitt, HO Bravo-Abad, J AF Chua, Song-Liang Caccamise, Christine A. Phillips, Dane J. Joannopoulos, John D. Soljacic, Marin Everitt, Henry O. Bravo-Abad, Jorge TI Spatio-temporal theory of lasing action in optically-pumped rotationally excited molecular gases SO OPTICS EXPRESS LA English DT Article ID FAR-INFRARED-LASER; ENERGY-TRANSFER; POLYATOMIC-MOLECULES; RATE EQUATIONS; (CH3F)-C-13 AB We investigate laser emission from optically-pumped rotationally excited molecular gases confined in a metallic cavity. To this end, we have developed a theoretical framework able to accurately describe, both in the spatial and temporal domains, the molecular collisional and diffusion processes characterizing the operation of this class of lasers. The effect on the main lasing features of the spatial variation of the electric field intensity and the ohmic losses associated to each cavity mode are also included in our analysis. Our simulations show that, for the exemplary case of methyl fluoride gas confined in a cylindrical copper cavity, the region of maximum population inversion is located near the cavity walls. Based on this fact, our calculations show that the lowest lasing threshold intensity corresponds to the cavity mode that, while maximizing the spatial overlap between the corresponding population inversion and electric-field intensity distributions, simultaneously minimizes the absorption losses occurring at the cavity walls. The dependence of the lasing threshold intensity on both the gas pressure and the cavity radius is also analyzed and compared with experiment. We find that as the cavity size is varied, the interplay between the overall gain of the system and the corresponding ohmic losses allows for the existence of an optimal cavity radius which minimizes the intensity threshold for a large range of gas pressures. The theoretical analysis presented in this work expands the current understanding of lasing action in optically-pumped far-infrared lasers and, thus, could contribute to the development of a new class of compact far-infrared and terahertz sources able to operate efficiently at room temperature. (C) 2011 Optical Society of America C1 [Chua, Song-Liang] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Caccamise, Christine A.] Deloitte Consulting LLP, Arlington, VA 22209 USA. [Phillips, Dane J.] Kratos Def, Huntsville, AL 35805 USA. [Joannopoulos, John D.; Soljacic, Marin; Bravo-Abad, Jorge] MIT, Dept Phys, Cambridge, MA 02139 USA. [Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. [Bravo-Abad, Jorge] Univ Autonoma Madrid, Dept Fis Teor Mat Condensada, E-28049 Madrid, Spain. RP Chua, SL (reprint author), MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. EM csliang@mit.edu RI Everitt, Henry/L-7118-2013; OI Everitt, Henry/0000-0002-8141-3768; Bravo-Abad, Jorge/0000-0001-6876-8022 FU National Science Foundation [DMR-0819762]; Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-07-D0004]; Army's competitive in-house innovative laboratory; Spanish MICINN [RyC-2009-05489]; DSO National Laboratories, Singapore FX We acknowledge helpful discussions with Dr. Ofer Shapira and Prof. Steven Johnson. This work was supported in part by the MRSEC Program of the National Science Foundation under award number DMR-0819762, the Army Research Office through the Institute for Soldier Nanotechnologies under Contract No. W911NF-07-D0004, and the Army's competitive in-house innovative laboratory research program. J.B.-A. acknowledges financial support by Spanish MICINN through Ramon y Cajal program, grant no. RyC-2009-05489. Song-Liang Chua acknowledges the financial support from the DSO National Laboratories, Singapore. NR 21 TC 4 Z9 4 U1 0 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 11 PY 2011 VL 19 IS 8 BP 7513 EP 7529 DI 10.1364/OE.19.007513 PG 17 WC Optics SC Optics GA 762MI UT WOS:000290482500047 PM 21503059 ER PT J AU Beck, Z Brown, BK Matyas, GR Polonis, VR Rao, M Alving, CR AF Beck, Zoltan Brown, Bruce K. Matyas, Gary R. Polonis, Victoria R. Rao, Mangala Alving, Carl R. TI Infection of human peripheral blood mononuclear cells by erythrocyte-bound HIV-1: Effects of antibodies and complement SO VIROLOGY LA English DT Article DE HIV-1, 4E10 and b12; PBMC; Erythrocytes; HIV-1 neutralizing antibodies; HIV-1 enhancing antibodies; Complement-mediated neutralization and enhancement; Fc; CR1; CR2 ID IMMUNODEFICIENCY-VIRUS TYPE-1; DEPENDENT ENHANCEMENT; HUMORAL IMMUNITY; OPSONIZED HIV; FC-RECEPTORS; NEUTRALIZATION; GP41; PATHOGENESIS; INDIVIDUALS; MECHANISMS AB Two human monoclonal antibodies, 4E10 and b12, were examined for antibody-dependent neutralization, or antibody-dependent complement (C)-mediated neutralization, of infection of peripheral blood mononuclear cells (PBMC) by either free HIV-1 or trans infection by HIV bound to erythrocytes. Neutralization of free HIV-1 by b12 was stronger than by 4E10, but b12 neutralized erythrocyte-bound HIV-1 less efficiently than cell-free virus. 4E10 did not neutralize erythrocyte-bound HIV-1 and at a low concentration it caused enhancement of infection. Antibody (4E10)-dependent C activation inhibited trans infection by erythrocyte-bound HIV-1, but caused enhanced infection with cell-free HIV-1 in the presence of erythrocytes. No effects of C were observed with b12. C-dependent enhancement in the presence of erythrocytes is proposed as due to binding of C3b-4E10-cell-free-HIV or C3d-4E10-cell-free-HIV to C receptor type 1 (CR1) on erythrocytes, or C receptor type 2 (CR2) on B cells in the PBMC, followed by trans infection of susceptible cells. Published by Elsevier Inc. C1 [Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, Rockville, MD 20850 USA. [Beck, Zoltan; Brown, Bruce K.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. NR 31 TC 5 Z9 10 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD APR 10 PY 2011 VL 412 IS 2 BP 441 EP 447 DI 10.1016/j.virol.2011.01.037 PG 7 WC Virology SC Virology GA 740DZ UT WOS:000288773100022 PM 21334707 ER PT J AU Stermole, BM Grandits, GA Roediger, MP Clark, BM Ganesan, A Weintrob, AC Crum-Cianflone, NF Ferguson, TM Macalino, GE Landrum, ML AF Stermole, Benjamin M. Grandits, Greg A. Roediger, Mollie P. Clark, Brychan M. Ganesan, Anuradha Weintrob, Amy C. Crum-Cianflone, Nancy F. Ferguson, Tomas M. Macalino, Grace E. Landrum, Michael L. TI Long-term safety and serologic response to measles, mumps, and rubella vaccination in HIV-1 infected adults SO VACCINE LA English DT Article DE Measles; Mumps; MMR Vaccine; Human immunodeficiency virus; Vaccines; Vaccination ID ACTIVE ANTIRETROVIRAL THERAPY; HIV-INFECTED CHILDREN; REDUCTION NEUTRALIZATION ASSAY; IMMUNIZATION PRACTICES ACIP; VIRUS TYPE-1 INFECTION; VARICELLA VACCINE; ADVISORY-COMMITTEE; EDMONSTON-ZAGREB; UNITED-STATES; ANTIBODY AB We analyzed HIV viral load (VL) and CD4 count changes, and antibody responses following MMR vaccination of individuals in the U.S. Military HIV Natural History Study cohort. Cases receiving at least one dose of MMR vaccine after HIV diagnosis were matched 1:2 to HIV-positive controls not receiving the vaccine. Baseline was defined as time of vaccination for cases and indexed and matched to the time post-HIV diagnosis for controls. Changes in CD4 count and VL at 6, 12, 18 and 24 months were compared between cases and controls using a general linear model. Available sera from cases were tested for MMR seropositivity at baseline and post-vaccination at 6, 12, 18, and 24 months. Overall mean CD4 count change from baseline through 24 months was 20 (+/- 23) cells/mu L greater for cases than controls (p = 0.39). Similar non-significant changes in CD4 cell count were seen in the subset of those not on HAART at baseline. VL changes were small and similar between groups (mean differential change -0.04 (+/- 0.18) log(10) copies/mL; p = 0.84). Of 21 vaccinated participants with baseline serologic testing, 14(67%) were reactive to measles, 19 (91%) to mumps, and 20 (95%) to rubella. Three (43%) of 7 participants nonreactive to measles developed measles IgG; for mumps, 1(50%) of 2 developed mumps IgG; for rubella, 1(100%) developed rubella IgG. MMR vaccination did not result in detrimental immunologic or virologic changes through 24 months post-vaccination. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Stermole, Benjamin M.; Landrum, Michael L.] Brooke Army Med Ctr, San Antonio, TX USA. [Grandits, Greg A.; Roediger, Mollie P.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Grandits, Greg A.; Roediger, Mollie P.; Ganesan, Anuradha; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; Macalino, Grace E.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Clark, Brychan M.] Mike OCallaghan Fed Hosp, Nellis AFB, NV USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, San Diego, CA 92152 USA. [Ferguson, Tomas M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr,MCHE MDI, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org FU NIAID NIH HHS [HU0001-05-2-0011, Y1-AI-5072, Y01 AI005072]; PHS HHS [HU0001-05-2-0011] NR 51 TC 9 Z9 10 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 5 PY 2011 VL 29 IS 16 BP 2874 EP 2880 DI 10.1016/j.vaccine.2011.02.013 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 757CU UT WOS:000290062700010 PM 21352938 ER PT J AU Konduru, K Bradfute, SB Jacques, J Manangeeswaran, M Nakamura, S Morshed, S Wood, SC Bavari, S Kaplan, GG AF Konduru, Krishnamurthy Bradfute, Steven B. Jacques, Jerome Manangeeswaran, Mohanraj Nakamura, Siham Morshed, Sufi Wood, Steven C. Bavari, Sina Kaplan, Gerardo G. TI Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice SO VACCINE LA English DT Article DE Filoviridae; Glycoprotein; Fc fusion protein; Vaccine; Mouse model; Zaire Ebola virus; Neutralizing antibodies; T-cell immunity; Interferon-gamma ID ATTENUATED RECOMBINANT VACCINE; VESICULAR STOMATITIS VIRUSES; T-CELL RESPONSES; NONHUMAN-PRIMATES; MARBURG VIRUS; HEMORRHAGIC-FEVER; GUINEA-PIGS; POSTEXPOSURE PROTECTION; PARTICLES PROTECT; INFECTION AB Ebola virus is a Filoviridae that causes hemorrhagic fever in humans and induces high morbidity and mortality rates. Filoviruses are classified as "Category A bioterrorism agents", and currently there are no licensed therapeutics or vaccines to treat and prevent infection. The Filovirus glycoprotein (GP) is sufficient to protect individuals against infection, and several vaccines based on GP are under development including recombinant adenovirus, parainfluenza virus, Venezuelan equine encephalitis virus, vesicular stomatitis virus (VSV) and virus-like particles. Here we describe the development of a GP Fc fusion protein as a vaccine candidate. We expressed the extracellular domain of the Zaire Ebola virus (ZEBOV) GP fused to the Fc fragment of human IgG1 (ZEBOVGP-Fc) in mammalian cells and showed that GP undergoes the complex furin cleavage and processing observed in the native membrane-bound GP. Mice immunized with ZEBOVGP-Fc developed T-cell immunity against ZEBOV GP and neutralizing antibodies against replication-competent VSV-G deleted recombinant VSV containing ZEBOV GP. The ZEBOVGP-Fc vaccinated mice were protected against challenge with a lethal dose of ZEBOV. These results show that vaccination with the ZEBOVGP-Fc fusion protein alone without the need of a viral vector or assembly into virus-like particles is sufficient to induce protective immunity against ZEBOV in mice. Our data suggested that Filovirus GP Fc fusion proteins could be developed as a simple, safe, efficacious, and cost effective vaccine against Filovirus infection for human use. Published by Elsevier Ltd. C1 [Konduru, Krishnamurthy; Jacques, Jerome; Manangeeswaran, Mohanraj; Nakamura, Siham; Morshed, Sufi; Kaplan, Gerardo G.] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Wood, Steven C.] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA. [Bradfute, Steven B.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Kaplan, GG (reprint author), US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. EM gk@helix.nih.gov FU CBER/FDA - NIAID/NIH [Y1-AI-6153-01, Y1-AI-0664-01]; Biomedical Advanced Research and Development Authority (BARDA); Food and Drug Administration; USAMRIID FX This work was supported by CBER/FDA - NIAID/NIH Interagency Agreements Y1-AI-6153-01 and Y1-AI-0664-01, grants from the Biomedical Advanced Research and Development Authority (BARDA) to GGK, intramural funding from the Food and Drug Administration to GGK, and USAMRIID to SB. This article reflects the views of the author and should not be construed to represent FDA's views or policies. NR 50 TC 24 Z9 28 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD APR 5 PY 2011 VL 29 IS 16 BP 2968 EP 2977 DI 10.1016/j.vaccine.2011.01.113 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 757CU UT WOS:000290062700022 PM 21329775 ER PT J AU Simprini, LA Rich, ME Villines, TC Munir, JA Taylor, AJ AF Simprini, Lauren A. Rich, Michael E. Villines, Todd C. Munir, Jamalah A. Taylor, Allen J. TI NON-HDL CHOLESTEROL IS ASSOCIATED WITH CORONARY ARTERY CALCIUM INDEPENDENT OF LDL, HDL, EXERCISE AND DIET SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 60th Annual Scientific Session and Expo of the American-College-of-Cardiology CY APR 03-05, 2011 CL New Orleans, LA SP Amer Coll Cardiol C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR 5 PY 2011 VL 57 IS 14 SU 1 BP E834 EP E834 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 778HR UT WOS:000291695100835 ER PT J AU Simprini, LA Munir, JA Villines, TC Taylor, AJ AF Simprini, Lauren A. Munir, Jamalah A. Villines, Todd C. Taylor, Allen J. TI RISK FACTOR, ANDROGEN HORMONE AND IMAGING ASSOCIATIONS WITH PERIMENOPAUSAL CONVERSION TO A NON-ZERO CALCIUM SCORE SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 60th Annual Scientific Session and Expo of the American-College-of-Cardiology CY APR 03-05, 2011 CL New Orleans, LA SP Amer Coll Cardiol C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR 5 PY 2011 VL 57 IS 14 SU 1 BP E828 EP E828 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 778HR UT WOS:000291695100829 ER PT J AU Villines, TC Hulten, E Dunning, A Shaw, LJ Achenbach, S Al-Mallah, M Berman, DS Budoff, MJ Cademartiri, F Callister, T Chang, HJ Chow, BJW Delago, A Hadamitzky, M Hausleiter, J Kaufmann, P Lin, FY Raff, GL Goyal, M Min, JK AF Villines, Todd C. Hulten, Edward Dunning, Alison Shaw, Leslee J. Achenbach, Stephan Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Chang, Hyuk-Jae Chow, Benjamin J. W. Delago, Augustine Hadamitzky, Martin Hausleiter, Joerg Kaufmann, Philipp Lin, Fay Y. Raff, Gilbert L. Goyal, Manju Min, James K. CA CONFIRM Investigators TI ABSENCE OF CORONARY ARTERY CALCIUM DOES NOT FULLY EXCLUDE OBSTRUCTIVE CORONARY ARTERY DISEASE AND FUTURE ADVERSE EVENTS AMONG PATIENTS REFERRED FOR CARDIAC CT ANGIOGRAPHY: RESULTS FROM 17,528 PATIENTS IN THE CONFIRM REGISTRY (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY) SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 60th Annual Scientific Session and Expo of the American-College-of-Cardiology CY APR 03-05, 2011 CL New Orleans, LA SP Amer Coll Cardiol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Weill Cornell Med Coll, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR 5 PY 2011 VL 57 IS 14 SU 1 BP E2035 EP E2035 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 778HR UT WOS:000291695102040 ER PT J AU Crone, JC Knap, J Chung, PW Rice, BM AF Crone, Joshua C. Knap, Jaroslaw Chung, Peter W. Rice, Betsy M. TI Role of microstructure in initiation of Ni-Al reactive multilayers SO APPLIED PHYSICS LETTERS LA English DT Article ID FILMS; IGNITION; FOILS; NICKEL AB Through molecular dynamics simulations, the effects of microstructure on reaction initiation are studied in nickel-aluminum (Ni-Al) reactive multilayers. Ni-Al multilayer systems of varying misfit strain and layer thickness are created and the ignition temperature is estimated by heating and thermalizing over small temperature increments until a reaction is observed. Results show that ignition temperatures drop significantly with increasing misfit strain. Our results indicate that the sensitivity of reactive multilayers can be controlled, in part, by microstructure, with changes of the order of 350 K. [doi: 10.1063/1.3575576] C1 [Crone, Joshua C.; Knap, Jaroslaw; Chung, Peter W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Crone, JC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joshua.crone@us.army.mil FU DoD High Performance Computing Modernization Office through the Multiscale Reactive Modeling on Insensitive Munitions Software Applications Institute FX The support of the DoD High Performance Computing Modernization Office through the Multiscale Reactive Modeling on Insensitive Munitions Software Applications Institute is gratefully acknowledged. NR 24 TC 19 Z9 19 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 4 PY 2011 VL 98 IS 14 AR 141910 DI 10.1063/1.3575576 PG 3 WC Physics, Applied SC Physics GA 747CL UT WOS:000289297800025 ER PT J AU Reese, MS Balanis, CA Birtcher, CR Barber, GC AF Reese, Mark S. Balanis, Constantine A. Birtcher, Craig R. Barber, George C. TI Modeling and Simulation of a Helicopter-Mounted SATCOM Antenna Array SO IEEE ANTENNAS AND PROPAGATION MAGAZINE LA English DT Article DE Array antennas; satellite communication; helicopter antennas; microstrip antennas AB A seven-element helicopter-mounted microstrip-patch switched-beam antenna array for satellite communications (SATCOM) is described. The performance of the array antenna was simulated. A prototype was constructed, and measurements of the antenna's patterns were made. The effects of the blades of the helicopter on the patterns of the antenna were investigated. Fluctuations of 10 dB or more in magnitude due to the effects of the blades were observed in the patterns. C1 [Reese, Mark S.; Balanis, Constantine A.; Birtcher, Craig R.] Arizona State Univ, Dept Elect Comp & Energy Engn, Tempe, AZ 85287 USA. [Barber, George C.] USA, Aviat Appl Technol Directorate MTD, Ft Eustis, VA 23604 USA. RP Reese, MS (reprint author), Arizona State Univ, Dept Elect Comp & Energy Engn, Tempe, AZ 85287 USA. EM balanis@asu.edu FU Arizona State University FX This work was sponsored by the Advanced Helicopter Electromagnetics (AHE) program at Arizona State University. NR 9 TC 6 Z9 6 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1045-9243 J9 IEEE ANTENN PROPAG M JI IEEE Antennas Propag. Mag. PD APR PY 2011 VL 53 IS 2 BP 51 EP 60 DI 10.1109/MAP.2011.5949326 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 893LS UT WOS:000300358000005 ER PT J AU Macedonia, CR Rosen, JM Dean, WK AF Macedonia, Christian R. Rosen, Joseph M. Dean, Wendy K. TI Virtual Valley Forge: A Revolutionary Hospital Concept SO MILITARY MEDICINE LA English DT Editorial Material C1 [Macedonia, Christian R.] DARPA DSO, Joint Chiefs Staff, Arlinton, VA 22203 USA. [Rosen, Joseph M.] Dartmouth Hitchcock Med Ctr, Dept Plast Surg, Lebanon, NH 03756 USA. [Dean, Wendy K.] USA, Allied Technol & Consulting LLC, Armed Forces Inst Regenerat Med, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Macedonia, CR (reprint author), DARPA DSO, Joint Chiefs Staff, 3701 N Fairfax Dr, Arlinton, VA 22203 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2011 VL 176 IS 4 BP 357 EP 358 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 825BO UT WOS:000295246100001 PM 21539153 ER PT J AU Waits, WM Wise, J AF Waits, Wendi M. Wise, Joseph TI The Fort Campbell High Interest Program SO MILITARY MEDICINE LA English DT Editorial Material ID SERVICES; SUICIDE C1 [Waits, Wendi M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wise, Joseph] Blanchfield Army Community Hosp, Ft Campbell, KY 42223 USA. RP Waits, WM (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2011 VL 176 IS 4 BP 359 EP 360 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 825BO UT WOS:000295246100002 PM 21539154 ER PT J AU De Lorenzo, RA Pfaff, JA AF De Lorenzo, Robert A. Pfaff, James A. TI Clinical Quality Management in the Combat Zone: The Good, the Bad, and the Unintended Consequences SO MILITARY MEDICINE LA English DT Article ID HEALTH-CARE; MEDICAL ERRORS; PERFORMANCE; IMPROVEMENT; TRAUMA; WAR; INDICATORS; ASSURANCE; DELIVERY; PROGRAM AB Clinical quality management (CQM) is a fixture of modern U.S. healthcare to include fixed military medical treatment facilities. CQM is now being applied to the battlefield. In a related fashion, standards of care have been proposed in the context of combat medicine. The overall goal is to improve the medical care of casualties. Despite good intentions, the concepts and execution of CQM and standards of care are neither well-described in the literature nor established in official military doctrine and regulation. This has resulted in variable and haphazard applications that range from the positive and supportive to the negative and counterproductive. This article outlines the use of CQM in combat. operations and asserts that a deliberate analysis of the benefits and risks is needed before its continued use. Future directions should focus on the impact of CQM on mission, doctrine, training, staffing, and unit organization. Rigorous adherence to evidence of effectiveness is essential before applying CQM in the combat zone. C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.; Pfaff, James A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Pfaff, James A.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. NR 42 TC 0 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2011 VL 176 IS 4 BP 375 EP 380 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 825BO UT WOS:000295246100006 PM 21539158 ER PT J AU Baxi, NS Jackson, JL Ritter, J Sessums, LL AF Baxi, Nancy S. Jackson, Jeffrey L. Ritter, Joan Sessums, Laura L. TI How Well do the Framingham Risk Factors Correlate With Diagnoses of Ischemic Heart Disease and Cerebrovascular Disease in a Military Beneficiary Cohort? SO MILITARY MEDICINE LA English DT Article ID LIFETIME RISK; STROKE; POPULATION; PREDICTION; VALIDATION; PROFILE; TRENDS AB We sought to determine how well the Framingham prediction rules correlate with ischemic heart disease and cerebrovascular disease in a military beneficiary cohort by examining demographic and International Classification of Diseases, Ninth Revision codes from electronic medical records between 2001 and 2008. This sample (n = 163,627) included people averaged at 52 years of age (range 18-108); slightly more than half were male (55%), 21% were African-American, and 59% were Caucasian. Fifteen percent of beneficiaries had ischemic heart disease and 3.4% had cerebrovascular disease. The Framingham model fits our data well; all Framingham risk factors were associated with increased likelihood of ischemic heart disease and all Framingham risk factors except gender increased cerebrovascular disease prevalence. Age was the strongest correlate for both ischemic heart disease and cerebrovascular disease (>60 years old; ischemic heart disease relative risk, 3.9; 95% confidence interval, 3.7-4.0; cardiovascular disease relative risk, 3.9; 95% confidence interval, 3.6-4.2) followed by hyperlipidemia and hypertension. We conclude that military clinicians can risk stratify military beneficiaries using the Framingham risk model. C1 [Baxi, Nancy S.; Jackson, Jeffrey L.; Ritter, Joan; Sessums, Laura L.] Walter Reed Army Med Ctr, Div Gen Med, Washington, DC 20305 USA. RP Baxi, NS (reprint author), Walter Reed Army Med Ctr, Div Gen Med, 6900 Georgia Aveue NW, Washington, DC 20305 USA. NR 22 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2011 VL 176 IS 4 BP 408 EP 413 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 825BO UT WOS:000295246100011 PM 21539163 ER PT J AU Labra, C Collen, J Cho, K Mikita, J AF Labra, Christian Collen, Jacob Cho, Kenneth Mikita, Jeffrey TI An Uncommon Cause of Chest Pain in the Deployed Soldier SO MILITARY MEDICINE LA English DT Article ID PULMONARY ARTERIOVENOUS-MALFORMATIONS; HEREDITARY HEMORRHAGIC TELANGIECTASIA; SPIRAL CT; EMBOLIZATION; EMBOLOTHERAPY; ANGIOGRAPHY; FISTULA AB Chest pain is a common complaint at medical treatment facilities during combat operations. The initial evaluation focuses on potentially life-threatening conditions (acute coronary syndrome, aortic dissection, pulmonary embolus), in addition to pericarditis and benign musculoskeletal conditions such as costochondritis. Pulmonary arteriovenous malformation is a rare condition, but an important diagnostic consideration in soldiers who present with chest pain and/or hypoxia and in whom other life-threatening conditions, such as cardiovascular disasters and pulmonary embolus, are excluded. We present the case of a male soldier deployed to Operation Iraqi Freedom, who was air-evacuated back to Washington, DC, for definitive care. We present his case and a review of the relevant literatures on the diagnosis and treatment of patients with pulmonary arteriovenous malformations. C1 [Labra, Christian] Dewitt Army Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA. [Collen, Jacob] Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. [Cho, Kenneth] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Mikita, Jeffrey] Walter Reed Army Med Ctr, Dept Pulmonol Crit Care & Sleep Med, Washington, DC 20307 USA. RP Labra, C (reprint author), Dewitt Army Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA. NR 26 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2011 VL 176 IS 4 BP 414 EP 419 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 825BO UT WOS:000295246100012 PM 21539164 ER PT J AU Milburn, M Rosman, M Mylander, WC Liang, W Hooke, J Kovatich, A AF Milburn, Meghan Rosman, Martin Mylander, W. Charles Liang, Wen Hooke, Jeffrey Kovatich, Al TI Does Tumor Immunohistochemistry Discordance Between Core Needle Biopsy and Mastectomy Raise Concerns for Treatment Recommendations? SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 12th Annual Meeting of the American-Society-of-Breast-Surgeons CY APR 27-MAY 01, 2011 CL Washington, DC SP Amer Soc Breast Surg C1 [Milburn, Meghan; Rosman, Martin; Mylander, W. Charles; Liang, Wen] Anne Arundel Med Ctr, Annapolis, MD USA. [Hooke, Jeffrey; Kovatich, Al] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD APR PY 2011 VL 18 SU 2 BP S176 EP S176 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 791HP UT WOS:000292656100074 ER PT J AU Filocamo, S Stote, R Ziegler, D Gibson, H AF Filocamo, Shaun Stote, Robert Ziegler, David Gibson, Heidi TI Entrapment of DFPase in titania coatings from a biomimetically derived method SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID IMPREGNATED SILICA NANOPARTICLES; ENZYME ENCAPSULATION; PHOTOCATALYTIC DEGRADATION; CYLINDROTHECA-FUSIFORMIS; POLYSTYRENE SPHERES; TEMPLATED SYNTHESIS; ROOM-TEMPERATURE; LOLIGO-VULGARIS; HOLLOW SILICA; PART 1 AB Silicon oxide has been widely used to encapsulate biomolecules to preserve their activity in less than ideal environments. However, there are other inorganic oxides with inherent properties that would be advantageous in creating a multifunctional material. Titanium oxide exhibits properties that have applications in areas such as electronics, energy conversion, and decontamination. Herein is reported the formation of titania coatings fabricated on polymer beads using a biomimetic approach and characterized with scanning electron microscopy and energy dispersive x-ray spectroscopy. The approach involves the use of functionalized polymer beads, which initiate oxide formation from a water-soluble titanium complex. The method was used to encapsulate the enzyme diisopropylfluorophosphatase, in situ, within the oxide matrix under buffered aqueous conditions while retaining its enzymatic activity against diisopropylfluorophosphate. In addition, the biomimetically produced titania was shown to exhibit UV-assisted degradation activity against an ethidium bromide dye, upon liberation from the coating template. C1 [Filocamo, Shaun; Stote, Robert; Ziegler, David; Gibson, Heidi] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Filocamo, S (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM Shaun.Filocamo@us.army.mil FU Defense Threat Reduction Agency FX This research was funded by the Defense Threat Reduction Agency. The authors acknowledge Dr. John Walker for his assistance with the DFPase activity assay and Dr. Lian Li and Professor Jayant Kumar from the University of Massachusetts-Lowell for their assistance with x-ray diffraction of the titania-coated Sephadex beads. NR 70 TC 4 Z9 4 U1 2 U2 17 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD APR PY 2011 VL 26 IS 8 BP 1042 EP 1051 DI 10.1557/jmr.2011.33 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 793NA UT WOS:000292829000013 ER PT J AU Sun, J Choi, KK Jhabvala, MD Jhabvala, C AF Sun, Jason Choi, Kwong-Kit Jhabvala, Merzy D. Jhabvala, Christine TI Advanced substrate thinning process for GaAs-based devices SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS LA English DT Article DE inductively coupled plasma selective etching; corrugated quantum well infrared photodetector focal plane arrays; GaAs substrate thinning ID ALGAAS; ETCH; PLASMAS; LAYERS; DAMAGE AB We developed an optimized substrate removal process for GaAs-based opto-electronic devices by establishing a reliable two-step process. In this process, the substrate is first thinned by mechanical lapping and then followed by selective high density plasma etching. The adopted inductively coupled plasma etching, having an optimized boron trichloride (BCl3)/sulfur hexafluoride (SF6)/argon composition, shows a nearly infinite etching selectivity for the GaAs substrate over the aluminum gallium arsenide (AlxGa1-xAs) etch-stop layer. The surface of the die is perfectly smooth and mirror-like after processing. In addition to its simplicity, the process is also highly reproducible and shows no damage to the underlying detector material. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI:10.1117/1.3580755] C1 [Sun, Jason; Choi, Kwong-Kit] USA, Res Lab, Adelphi, MD 20783 USA. [Jhabvala, Merzy D.; Jhabvala, Christine] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP Sun, J (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jason.sun@arl.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 11 TC 5 Z9 5 U1 0 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1932-5150 J9 J MICRO-NANOLITH MEM JI J. Micro-Nanolithogr. MEMS MOEMS PD APR-JUN PY 2011 VL 10 IS 2 AR 023004 DI 10.1117/1.3580755 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics SC Engineering; Science & Technology - Other Topics; Materials Science; Optics GA 787JU UT WOS:000292373200006 ER PT J AU Bedair, SS Meyer, CD Morgan, B AF Bedair, Sarah S. Meyer, Christopher D. Morgan, Brian TI Closed core inductor and high-K dielectric capacitor fabrication through evaporation driven nanoparticle assembly in capillaries SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DENSITY AB This paper outlines a low-cost multimaterial, integrated passives approach involving suspension wicking of high-K dielectric and ferromagnetic nanoparticles into capillaries comprising inductor and capacitor passive devices. The suspension is deposited into a "target well" and nanoparticles are delivered to the passive via fluidic self-assembly, resulting in inductor and capacitor value improvements. The universality of this approach has been demonstrated through the fabrication and testing of both MEMS inductors and capacitors on a single substrate, which would otherwise be fabrication-intense using traditional fabrication methods. This approach has demonstrated inductance improvements of 45% up to 500 MHz with roll-off in quality factor past 225 MHz after wicking of a NiFe(2)O(4) nanoparticle core. In addition, capacitance was increased 400% and 600% after wicking of BaTiO(3) nanoparticles/polymer composite into 1- and 2-mm-long capacitor constructs, respectively. (C) 2011 American Institute of Physics. [doi:10.1063/1.3535420] C1 [Bedair, Sarah S.; Meyer, Christopher D.; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. [Meyer, Christopher D.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. RP Bedair, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM sarah.bedair@us.army.mil RI Bedair, Sarah/D-9130-2013 NR 9 TC 3 Z9 3 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2011 VL 109 IS 7 AR 07E702 DI 10.1063/1.3535420 PG 3 WC Physics, Applied SC Physics GA 755QV UT WOS:000289952100423 ER PT J AU Britzke, ER Duchamp, JE Murray, KL Swihart, RK Robbins, LW AF Britzke, Eric R. Duchamp, Joseph E. Murray, Kevin L. Swihart, Robert K. Robbins, Lynn W. TI Acoustic Identification of Bats in the Eastern United States: A Comparison of Parametric and Nonparametric Methods SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE acoustic identification; Anabat; discriminant function analysis; echolocation; neural networks; quantitative identification; ultrasonic detectors ID ARTIFICIAL NEURAL-NETWORKS; TIME-EXPANDED RECORDINGS; ECHOLOCATION CALLS; CHALINOLOBUS-TUBERCULATUS; MYSTACINA-TUBERCULATA; INSECTIVOROUS BATS; LASIURUS-CINEREUS; MYOTIS-LUCIFUGUS; CAUTIONARY NOTE; BIG BROWN AB Ultrasonic detectors are widely used to survey bats in ecological studies. To evaluate efficacy of acoustic identification, we compiled a library of search phase calls from across the eastern United States using the Anabat system. The call library included 1,846 call sequences of 12 species recorded from 14 states. We determined accuracy rates using 3 parametric and 4 nonparametric classification functions for acoustic identification. The 2 most flexible classification functions also were the most accurate: neural networks (overall classification accuracy = 0.94) and mixture discriminant analysis incorporating an adaptive regression model (overall classification accuracy = 0.93). Flexible nonparametric methods offer substantial benefits when discriminating among closely related species and may preclude the need to group species with similar calls. We demonstrate that quantitative methods provide an effective technique to acoustically identify bats in the eastern United States with known accuracy rates. (C) 2011 The Wildlife Society. C1 [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Duchamp, Joseph E.] Indiana Univ Penn, Dept Biol, Indiana, PA 15705 USA. [Murray, Kevin L.] Univ Miami, Dept Biol, Coral Gables, FL 33124 USA. [Swihart, Robert K.] Purdue Univ, Dept Forestry & Nat Resources, Lafayette, IN 47907 USA. [Robbins, Lynn W.] Missouri State Univ, Dept Biol, Springfield, MO 65804 USA. RP Britzke, ER (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM eric.r.britzke@usace.army.mil RI Swihart, Rob/D-2787-2016 FU United States Fish and Wildlife Service; United States Forest Service; Missouri Department of Conservation FX Financial support for this project was provided by the United States Fish and Wildlife Service, United States Forest Service, and Missouri Department of Conservation. The Department of Biology and Center for the Management, Utilization, and Protection of Water Resources at Tennessee Technological University and the Department of Biology at Missouri State University provided additional valuable support to the project. The United States Forest Service, Missouri Department of Conservation, Great Smoky Mountains National Park, and Mammoth Cave National Park provided access to their lands. C. Corben provided extensive assistance for his technical advice on the use of the Analook software. J. Belwood, C. Butchkoski, and A. Tibbels provided calls included in the call library. Numerous individuals assisted in the collection of known calls in the field, especially: S. Amelon, D. Bossi, R. Currie, B. Hadley, M. Harvey, A. Hicks, and J. MacGregor. Additionally, we thank J. Lusk, B. Pijanowski, K. Alexandridis, and S. Pithadia for their advice on neural network architecture. T. Carter, D. Combs, B. Fenton, S. Loeb, A. Tibbels, and M. Vonhoff provided helpful comments on earlier versions of this study. NR 42 TC 24 Z9 27 U1 5 U2 49 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD APR PY 2011 VL 75 IS 3 BP 660 EP 667 DI 10.1002/jwmg.68 PG 8 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 769JD UT WOS:000291007800022 ER PT J AU Fry, LW Hannah, ST Noel, M Walumbwa, FO AF Fry, Louis W. Hannah, Sean T. Noel, Michael Walumbwa, Fred O. TI Impact of spiritual leadership on unit performance (Retracted article. See vol. 25, pg. 1073, 2014) SO LEADERSHIP QUARTERLY LA English DT Article; Retracted Publication DE Spiritual leadership; Military; Workplace spirituality; Performance; Emergent leadership ID TRANSFORMATIONAL LEADERSHIP; ETHICAL LEADERSHIP; MEMBER EXCHANGE; WORK; ANTECEDENTS; PERSPECTIVE; COMMITMENT; MULTILEVEL; WORKPLACE; AGREEMENT AB Issues regarding workplace spirituality have received increased attention in the organizational sciences. The implications of workplace spirituality for leadership theory, research, and practice make this a fast growing area of new research and inquiry by scholars. The purpose of this research was to test a dynamic relationship between spiritual leadership and spiritual well-being (i.e., a sense of calling and membership), and key organizational outcomes in a sample of emerging military leaders. Using structural equation modeling (SEM), results revealed a positive and significant relationship between spiritual leadership and several unit-level outcomes, including organizational commitment and four measures of performance. These relationships were explained or mediated by spiritual well-being. Implications for research and practice are discussed. (C) 2011 Elsevier Inc. All rights reserved. C1 [Fry, Louis W.] Texas A&M Cent Texas, Killeen, TX 76549 USA. [Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. [Noel, Michael] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Walumbwa, Fred O.] Arizona State Univ, WP Carey Sch Business, Dept Management, Tempe, AZ 85287 USA. RP Fry, LW (reprint author), Texas A&M Cent Texas, 1901 S Clear Creek Rd, Killeen, TX 76549 USA. EM lwfry@ct.tamus.edu; Sean.Hannah@usma.edu; michael.alan.noel@us.army.mil; Fred.Walumbwa@asu.edu RI Meeuwsen, Sjaak/F-9186-2011 NR 86 TC 24 Z9 27 U1 5 U2 42 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD APR PY 2011 VL 22 IS 2 SI SI BP 259 EP 270 DI 10.1016/j.leaqua.2011.02.002 PG 12 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 768GJ UT WOS:000290921600002 ER PT J AU Pinson, AO AF Pinson, Ariane O. TI THE CLOVIS OCCUPATION OF THE DIETZ SITE (35LK1529), LAKE COUNTY, OREGON, AND ITS BEARING ON THE ADAPTIVE DIVERSITY OF CLOVIS FORAGERS SO AMERICAN ANTIQUITY LA English DT Article ID NORTH-AMERICA; LATE PLEISTOCENE; REGIONAL VARIABILITY; AGE; USA; GEOARCHAEOLOGY; TECHNOLOGIES; CHRONOLOGY; MIGRATION; MOBILITY AB Archaeological models of Clovis adaptations are divided between those that argue for a single hunting adaptation characterized by high residential mobility without fixed territories and those that argue for a diversity of environment-specific adaptations and settlement systems. The Dietz site (35LK1529), the largest Clovis site in the Pacific Northwest, is composed of many overlapping, spatially coherent artifact clusters from which 75 whole and fragmentary fluted points have been recovered. The artifact assemblage is inconsistent with use of the site as a kill, camp, or quarry site. Geoarchaeological data show that the site area during the Clovis occupation was a sparsely vegetated, seasonal playa that is unlikely to have supported large herds of game animals. However, the site sits astride what was probably a major transportation corridor linking highly productive ecosystems in the adjoining basins, and Clovis foragers appear to have camped at Dietz repeatedly while traveling between these nearby basins. The systematic and redundant use of a geographically small landscape by Clovis foragers is inconsistent with expectations based on a model of residentially mobile foragers occupying new territories. C1 USA, Corps Engineers, Albuquerque, NM 87109 USA. RP Pinson, AO (reprint author), USA, Corps Engineers, 4101 Jefferson Plaza NE, Albuquerque, NM 87109 USA. EM Ariane.Pinson@usace.army.mil NR 110 TC 5 Z9 6 U1 1 U2 8 PU SOC AMER ARCHAEOLOGY PI WASHINGTON PA 900 SECOND ST., NE STE 12, WASHINGTON, DC 20002-3557 USA SN 0002-7316 J9 AM ANTIQUITY JI Am. Antiq. PD APR PY 2011 VL 76 IS 2 BP 285 EP 313 PG 29 WC Anthropology; Archaeology SC Anthropology; Archaeology GA 758CA UT WOS:000290136300004 ER PT J AU Lai, HQ Liu, KJR AF Lai, Hung-Quoc Liu, K. J. Ray TI Space-Time Network Coding SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Cooperative communications; frequency synchronization; linear network coding; space-time network codes; timing synchronization; wireless network cocast ID COOPERATIVE DIVERSITY; WIRELESS NETWORKS; PERFORMANCE ANALYSIS; FADING CHANNELS; CODES; COMMUNICATION; PROTOCOLS; DESIGN; POWER AB Traditional cooperative communications can improve communication reliability. However, transmissions from multiple relay nodes are challenging in practice. Single transmissions in time-division multiple-access (TDMA) manner cause large transmission delay, but simultaneous transmissions from two or more nodes using frequency-division multiple access (FDMA) and code-division multiple access (CDMA) are associated with the issue of imperfect frequency and timing synchronization. In this work, a novel framework for cooperative communications is proposed to achieve full spatial diversity with low transmission delay and eliminate the issue of imperfect synchronization. This is realized by the use of space-time network codes (STNCs) associated with a novel concept of wireless network cocast. For a network of N client nodes, R relay nodes and a base node, the STNCs provide a diversity order of (R + 1) for each symbol with (N + R) time slots, a reduction from 2N time slots in traditional FDMA and CDMA cooperative communications for N being usually greater than R and from N(R + 1) time slots in traditional TDMA cooperative communications. The STNCs are also applied in networks, where the client nodes located in a cluster act as relays to help one another to improve their transmission performance. The performance in clustering setting is studied to show the improvement in power saving, range extension, and transmission rate. C1 [Lai, Hung-Quoc] USA, RDECOM CERDEC, RDER STA DS, Aberdeen Proving Ground, MD 21005 USA. [Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Lai, HQ (reprint author), USA, RDECOM CERDEC, RDER STA DS, Aberdeen Proving Ground, MD 21005 USA. EM hungquoc.lai@us.army.mil; kjrliu@umd.edu RI Liu, K. J. Ray/C-2798-2009 NR 35 TC 32 Z9 33 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD APR PY 2011 VL 59 IS 4 BP 1706 EP 1718 DI 10.1109/TSP.2010.2103063 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 766TT UT WOS:000290810100029 ER PT J AU Copeland, LA Zeber, JE Bingham, MO Pugh, MJ Noel, PH Schmacker, ER Lawrence, VA AF Copeland, Laurel A. Zeber, John E. Bingham, Mona O. Pugh, Mary Jo Noel, Polly Hitchcock Schmacker, Eric R. Lawrence, Valerie A. TI Transition from military to VHA care: Psychiatric health services for Iraq/Afghanistan combat-wounded SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE Combat disorders; Health services; Iraq War 2003-; Mental health services; Veterans ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ; VETERANS; AFGHANISTAN; DEPRESSION; DEPLOYMENT; DIAGNOSES AB Objective: Veterans from the wars in Afghanistan and Iraq (OEF/OIF) report high rates of mental distress especially affective disorders. Ensuring continuity of care across institutions is a priority for both the Department of Defense (DOD) and the Veterans Health Administration (VHA), yet this process is not monitored nor are medical records integrated. This study assessed transition from DoD to VHA and subsequent psychiatric care of service members traumatically injured in OEF/OIF. Methods: Inpatients at a DoD trauma treatment facility discharged in FY02-FY06 (n = 994) were tracked into the VHA via archival data (n = 216 OEF/OIF veterans). Mental health utilization in both systems was analyzed. Results: VHA users were 9% female, 15% Hispanic; mean age 32 (SD= 10; range 19-59). No DoD inpatients received diagnoses of post-traumatic stress disorder (PTSD); 21% had other mental health diagnoses, primarily drug abuse. In the VHA, 38% sought care within 6 months of DoD discharge; 75% within 1 year. VHA utilization increased over time, with 88-89% of the transition cohort seeking care in FY07-FY09. Most accessed VHA mental health services (81%) and had VHA psychiatric diagnoses (71%); half met criteria for depression (27%) or PTSD (38%). Treatment retention through FY09 was significantly greater for those receiving psychiatric care: 98% vs 62% of those not receiving psychiatric care (chi(2)=53.3; p <.001). Limitations: DoD outpatient data were not available. The study relied on administrative data. Conclusions: Although physical trauma led to hospitalization in the DoD, high rates of psychiatric disorders were identified in subsequent VHA care, suggesting delay in development or recognition of psychiatric problems. Published by Elsevier B.V. C1 [Copeland, Laurel A.; Zeber, John E.] Scott & White Healthcare, Ctr Appl Hlth Res, Temple, TX 76502 USA. [Copeland, Laurel A.; Zeber, John E.] Vet Affairs, Cent Texaas Vet Hlth Care Syst, Temple, TX USA. [Bingham, Mona O.; Pugh, Mary Jo; Noel, Polly Hitchcock; Lawrence, Valerie A.] Vet Affairs, VERDICT Res, S Texas Vet Hlth Care Syst, San Antonio, TX USA. [Pugh, Mary Jo; Noel, Polly Hitchcock; Lawrence, Valerie A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schmacker, Eric R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Copeland, LA (reprint author), Scott & White Healthcare, Ctr Appl Hlth Res, 2102 Birdcreek Dr, Temple, TX 76502 USA. EM LaurelACopeland@gmail.com RI Schueter, nicos/A-3625-2014; OI Copeland, Laurel/0000-0002-9478-0209 FU Department of Veterans Affairs HSRD [SHP-08-0140]; VHA; DoD; Department of Veterans Affairs; VERDICT Research Center at South Texas Veterans Health Care System; Central Texas Veterans Health Care System; Scott & White Healthcare System; University of Texas Health Science Center at San Antonio; Brooke Army Medical Center at Fort Sam Houston; Nursing Research Services and the Department of Health Care Operations FX Funding for this study was provided by the Department of Veterans Affairs HSR&D Grant # SHP-08-0140. The funding agency had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.; The authors are employed as researchers by the Department of Veterans Affairs (VHA) or Department of Defense (DoD). The DoD researchers are stationed at the DoD hospital studied. The VHA researchers are supported by grants from non-profit agencies including VHA and DoD. The authors report no conflicts of interest.; This research was supported by the Department of Veterans Affairs with additional support from VERDICT Research Center at South Texas Veterans Health Care System, Central Texas Veterans Health Care System, Scott & White Healthcare System, and the University of Texas Health Science Center at San Antonio. The work was also supported by Brooke Army Medical Center at Fort Sam Houston, Nursing Research Services and the Department of Health Care Operations. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or the Department of Defense. NR 21 TC 13 Z9 13 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD APR PY 2011 VL 130 IS 1-2 BP 226 EP 230 DI 10.1016/j.jad.2010.10.017 PG 5 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 759KO UT WOS:000290241600033 PM 21051088 ER PT J AU Webb, HE Garten, RS McMinn, DR Beckman, JL Kamimori, GH Acevedo, EO AF Webb, Heather E. Garten, Ryan S. McMinn, David R. Beckman, Jamie L. Kamimori, Gary H. Acevedo, Edmund O. TI Stress hormones and vascular function in firefighters during concurrent challenges SO BIOLOGICAL PSYCHOLOGY LA English DT Article DE Cortisol; HPA axis; SA axis; Mental stress; Physical stress ID PITUITARY-ADRENAL AXIS; SUDDEN CARDIAC DEATH; LIVE-FIRE DRILLS; PSYCHOLOGICAL STRESS; HEART-DISEASE; MENTAL STRESS; RESPONSES; EXERCISE; INTERLEUKIN-6; BLOOD AB The purpose of this study was to examine the effects of concurrent physical and mental challenge on stress hormones and indicators of vascular function in firefighters. Twelve professional firefighters exercised at 60% VO(2max) while participating in a computerized Fire Strategies and Tactics Drill (FSTD-fire strategies condition [FSC]), and again at the same intensity without the mental challenge (EAC). No differences in the amount of work performed between conditions existed, although the FSC resulted in greater perceptions of overall workload. Epinephrine and norepinephrine demonstrated significant interaction effects with elevated levels during the FSC. Cortisol responses were significantly elevated across time and for the FSC. Positive correlations were found between cortisol and interleukin-6, endothelin-1, and thromboxane-B(2), and a negative correlation between interleukin-6 and thromboxane-B2. These results suggest that concurrent challenges results in exacerbated responses of stress hormones and suggests mechanisms that could contribute to the prevalence of cardiovascular events among firefighters. (C) 2011 Elsevier B.V. All rights reserved. C1 [Webb, Heather E.] Mississippi State Univ, Dept Kinesiol, Mississippi State, MS 39762 USA. [Garten, Ryan S.] Univ N Carolina, Greensboro, NC 27412 USA. [McMinn, David R.; Beckman, Jamie L.] Univ Mississippi, University, MS 38677 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Acevedo, Edmund O.] Virginia Commonwealth Univ, Richmond, VA USA. RP Webb, HE (reprint author), Mississippi State Univ, Dept Kinesiol, 121 McCarthy Gymnasium, Mississippi State, MS 39762 USA. EM hwebb@colled.msstate.edu RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 FU Mississippi Functional Genomics Network (Department of Health and Human Services/National Institutes of Health/National Center for Research Resources) [P20RR0167475-03] FX This work was supported by the Mississippi Functional Genomics Network (Department of Health and Human Services/National Institutes of Health/National Center for Research Resources grant #P20RR0167475-03). NR 70 TC 13 Z9 14 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 J9 BIOL PSYCHOL JI Biol. Psychol. PD APR PY 2011 VL 87 IS 1 BP 152 EP 160 DI 10.1016/j.biopsycho.2011.02.024 PG 9 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA 758VL UT WOS:000290195100019 PM 21382435 ER PT J AU Mumford, H Price, ME Lenz, DE Cerasoli, DM AF Mumford, Helen Price, Matthew E. Lenz, David E. Cerasoli, Douglas M. TI Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs SO CLINICAL TOXICOLOGY LA English DT Article DE Bioscavenger; Nerve agent; Percutaneous; Guinea pig; VX; Medical countermeasures ID NERVE AGENT VX; MICROINSTILLATION INHALATION EXPOSURE; MEDICAL COUNTERMEASURES; CYNOMOLGUS MONKEYS; DOMESTIC SWINE; PROTECTION; ATROPINE; SARIN; SOMAN; PHYSOSTIGMINE AB Context. Human butyrylcholinesterase (huBuChE) has potential utility as a post-exposure therapy following percutaneous nerve agent poisoning as there is a slower absorption of agent by this route and hence a later onset of poisoning. Methods. We used surgically implanted radiotelemetry devices to monitor heart rate, EEG, body temperature and locomotor activity in guinea pigs challenged with VX via the percutaneous route. Results. Treatment with huBuChE (24.2 mg/kg, i.m.) at 30 or 120 min following percutaneous VX (similar to 2.5 6 LD(50)) protected 9 out of 10 animals from lethality. When i.m. huBuChE administration was delayed until the onset of observable signs of systemic cholinergic poisoning, only one out of six animals survived to 7 days. Survival increased to 50% when the same dose of huBuChE was given intravenously at the onset of signs of poisoning. This dose represents approximately 1/10th the stoichiometric equivalent of the dose of VX administered (0.74 mg/kg). Intramuscular administration of huBuChE (24.2 mg/kg) alone did not produce any changes in heart rate, brain electrical activity, temperature or locomotion compared to saline control. Survival following VX and huBuChE treatment was associated with minimal incapacitation and observable signs of poisoning, and the mitigation or prevention of detrimental physiological changes (e.g. seizure, bradycardia and hypothermia) observed in VX + saline-treated animals. At 7 days, cholinesterase activity in the erythrocytes and most brain areas of guinea pigs that received huBuChE at either 18 h prior to or 30 min following VX was not significantly different from that of naive, weight-matched control animals. Conclusion. Percutaneous VX poisoning was successfully treated using post-exposure therapy with huBuChE bioscavenger. The opportunity for post-exposure treatment may have particular relevance in civilian settings, and this is a promising indication for the use of huBuChE. C1 [Mumford, Helen; Price, Matthew E.] Dstl, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. [Lenz, David E.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Mumford, H (reprint author), Dstl, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. EM hmumford@dstl.gov.uk OI Rice, Helen/0000-0002-7813-9374 FU UK Ministry of Defence FX The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This work was funded by the UK Ministry of Defence. (c) Crown Copyright, Defence Science and Technology Laboratory, UK, 2011. NR 31 TC 14 Z9 15 U1 1 U2 10 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD APR-MAY PY 2011 VL 49 IS 4 BP 287 EP 297 DI 10.3109/15563650.2011.568944 PG 11 WC Toxicology SC Toxicology GA 763DC UT WOS:000290533400003 PM 21563904 ER PT J AU Bhagwat, MJ AF Bhagwat, Mahendra J. TI Effect of Blade Number on Induced Power in Hover SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Hover performance is thought to be primarily affected by rotor solidity, and it has been suggested that the blade number does not have any effect on performance while comparing rotors with the same solidity. Vortex theory inherently includes the blade number effect but does not account for chord or solidity. For example, Goldstein's classical theory for lightly loaded propellers shows the effect of blade number (independent from blade chord or solidity) on optimum loading and induced power. Simpler analytical formulations, while less accurate, are more useful for understanding these effects. This paper employs combined blade element momentum theory augmented with a finite blade number or "tip loss" effect, using Prandtl's approximation to Goldstein's theory to study induced power in hover. An examination of induced flow effects resulting from finite blade number suggests, contrary to conventional wisdom, that blade number, and not just solidity, has a primary influence on the induced power in hover. Blade aspect ratio or mean nondimensional chord, the other constituent in solidity, appears to have a much smaller and secondary influence. This paper further addresses similarity considerations that can be applied to understand induced power trends. C1 USA, Res Dev & Engn Command, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Moffett Field, CA USA. RP Bhagwat, MJ (reprint author), USA, Res Dev & Engn Command, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Moffett Field, CA USA. EM mahendra.bhagwat@us.army.mil NR 14 TC 1 Z9 1 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2011 VL 56 IS 2 AR 022002 DI 10.4050/JAHS.56.022002 PG 8 WC Engineering, Aerospace SC Engineering GA 761RF UT WOS:000290415000002 ER PT J AU Datta, A Johnson, W AF Datta, Anubhav Johnson, Wayne TI Three-Dimensional Finite Element Formulation and Scalable Domain Decomposition for High-Fidelity Rotor Dynamic Analysis SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID ELLIPTIC PROBLEMS; SUBSTRUCTURING METHODS; PRECONDITIONERS; CONSTRUCTION; CONSTRAINTS; FETI AB This paper implements and analyzes a dual-primal iterative substructuring method that is parallel and scalable for the solution of a three-dimensional finite element based dynamic analysis of helicopter rotor blades. The analysis is developed using isoparametric hexahedral brick finite elements. Particular emphasis is placed on the formulation of the inertial terms that are unique to rotary wing dynamics. The scalability of the solution method is studied using two prototype problems one for steady hover (symmetric) and one for transient forward flight (nonsymmetric)-both carried out on up to 48 processors with each substructure on a separate processor. In both hover and forward flight, a linear speedup is observed with number of processors, up to the point of substructure optimality. Substructure optimality and the linear speedup range are shown to depend both on the problem size as well as a corner-based global coarse problem selection. An increase in problem size extends the linear speedup range up to a new substructure optimality. A smaller coarse problem selection extends optimality to a greater number of processors. The key conclusion is that a three-dimensional finite element analysis of a helicopter rotor can be carried out in a fully parallel and scalable manner. The careful selection of substructure corner nodes that are used to construct the global coarse problem is key to extending linear speedup to as high a processor number as possible, thus minimizing the solution time for a given problem size. C1 [Datta, Anubhav] NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. [Johnson, Wayne] NASA, Ames Res Ctr, Aeromech Branch, Moffett Field, CA 94035 USA. RP Datta, A (reprint author), NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. EM datta@merlin.arc.nasa.gov FU U.S. Department of Defense HPC Modernization Program Office FX Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the U.S. Department of Defense HPC Modernization Program Office. This research is conducted at the U. S. Army Aeroflightdynamics Directorate as part of the HPC Institute of Advanced Rotorcraft Modeling and Simulation (HI-ARMS) led by Dr. Roger Strawn. NR 35 TC 0 Z9 0 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2011 VL 56 IS 2 AR 022003 DI 10.4050/JAHS.56.022003 PG 14 WC Engineering, Aerospace SC Engineering GA 761RF UT WOS:000290415000003 ER PT J AU Komerath, NM Smith, MJ Tung, C AF Komerath, Narayanan M. Smith, Marilyn J. Tung, Chee TI A Review of Rotor Wake Physics and Modeling SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 35th Conference on European Rotorcraft Forum CY SEP 22-25, 2009 CL Hamburg, GERMANY ID COMPUTATIONAL FLUID-DYNAMICS; HELICOPTER FLIGHT MECHANICS; UNSTRUCTURED GRIDS; HOVER PERFORMANCE; REYNOLDS-NUMBER; TURBULENT FLOWS; VORTEX CORE; AERODYNAMICS; STALL; SIMULATION AB This paper presents an overview of developments in rotorcraft wake modeling, particularly in the past decade, from the experimental, theoretical, and computational viewpoints. Current understanding of wake physics and limitations in wake modeling are summarized and juxtaposed with trends experimental and numerical research. Advances in flow imaging and velocimetry have provided evidence that supports simplified models of rotor wake behavior. Persistence of tip vortices to long ages, deterministic rollup phenomena leading to the transition to the far wake, and entrainment of a part of the nascent tip vortex (TV) vorticity into the counterrotating inboard wake have been shown through experiments. Advances in computational fluid dynamics have improved near- and mid-wake modeling capabilities. Hybrid methods that employ vortex element, vorticity transport, or vorticity confinement methods will be necessary for long-age (far-wake) modeling in the near future. A new hover experiment with high-accuracy measurements that tie the blade loading, rotor performance, and wake characteristics is one suggestion to facilitate numerical model correlation and development. C1 [Komerath, Narayanan M.; Smith, Marilyn J.] Georgia Inst Technol, Daniel Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. [Tung, Chee] USA, Aeroflightdynam Directorate, Mountain View, CA USA. RP Komerath, NM (reprint author), Georgia Inst Technol, Daniel Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. EM narayanan.komerath@ae.gatech.edu RI Smith, Marilyn/E-4961-2012 NR 158 TC 4 Z9 7 U1 2 U2 10 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2011 VL 56 IS 2 AR 022006 DI 10.4050/JAHS.56.022006 PG 19 WC Engineering, Aerospace SC Engineering GA 761RF UT WOS:000290415000006 ER PT J AU Cashman, KA Smith, MA Twenhafel, NA Larson, RA Jones, KF Allen, RD Dai, DC Chinsangaram, J Bolken, TC Hruby, DE Amberg, SM Hensley, LE Guttieri, MC AF Cashman, Kathleen A. Smith, Mark A. Twenhafel, Nancy A. Larson, Ryan A. Jones, Kevin F. Allen, Robert D., III Dai, Dongcheng Chinsangaram, Jarasvech Bolken, Tove' C. Hruby, Dennis E. Amberg, Sean M. Hensley, Lisa E. Guttieri, Mary C. TI Evaluation of Lassa antiviral compound ST-193 in a guinea pig model SO ANTIVIRAL RESEARCH LA English DT Article DE Lassa virus; Arenavirus; Small molecule inhibitor; Fusion inhibitor; Glycoprotein; Guinea pig ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; HCV-COINFECTED PATIENTS; HEMATOLOGICAL TOXICITY; ENVELOPE GLYCOPROTEIN; CLINICAL-CHEMISTRY; CYNOMOLGUS MONKEYS; RIBAVIRIN THERAPY; IMMUNE PLASMA; SIERRA-LEONE; JUNIN VIRUS AB Lassa virus (LASV), a member of the Arenaviridae family, causes a viral hemorrhagic fever endemic to West Africa, where as many as 300,000 infections occur per year. Presently, there are no FDA-approved LASV-specific vaccines or antiviral agents, although the antiviral drug ribavirin has shown some efficacy. A recently identified small-molecule inhibitor of arenavirus entry, ST-193, exhibits submicromolar antiviral activity in vitro. To determine the antiviral utility of ST-193 in vivo, we tested the efficacy of this compound in the LASV guinea pig model. Four groups of strain 13 guinea pigs were administered 25 or 80 mg/kg ST-193, 25 mg/kg of ribavirin, or the vehicle by the intraperitoneal (i.p.) route before infection with a lethal dose of LASV, strain Josiah, and continuing once daily for 14 days. Control animals exhibited severe disease, becoming moribund between days 10 and 15 postinfection. ST-193-treated animals exhibited fewer signs of disease and enhanced survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups were elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediated a 2-3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs was 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups. These data suggest that ST-193 may serve as an improved candidate for the treatment of Lassa fever. (C) 2011 Elsevier B.V. All rights reserved. C1 [Larson, Ryan A.; Jones, Kevin F.; Allen, Robert D., III; Dai, Dongcheng; Chinsangaram, Jarasvech; Bolken, Tove' C.; Hruby, Dennis E.; Amberg, Sean M.] SIGA Technol Inc, Corvallis, OR 97333 USA. [Cashman, Kathleen A.; Hensley, Lisa E.; Guttieri, Mary C.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Smith, Mark A.; Twenhafel, Nancy A.] USA, Med Res Inst Infect Dis, Div Pathol, Frederick, MD USA. RP Amberg, SM (reprint author), SIGA Technol Inc, 4575 SW Res Way,Suite 230, Corvallis, OR 97333 USA. EM SAmberg@siga.com FU USAMRIID [06-1-TT-024, T0029_07]; NIH [R44 AI056525] FX We gratefully acknowledge Joan Geisbert for excellent technical assistance in phlebotomy and Monica Ogg for critical review of this manuscript. This work was supported under USAMRIID Research Plans 06-1-TT-024 and T0029_07, and by NIH SBIR grant R44 AI056525. All SIGA employees, as indicated by the authors' affiliations, own stock and/or stock options in the company. NR 69 TC 22 Z9 22 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2011 VL 90 IS 1 BP 70 EP 79 DI 10.1016/j.antiviral.2011.02.012 PG 10 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 759YP UT WOS:000290288100009 PM 21371508 ER PT J AU Na-Ubol, M Srimanote, P Chongsa-nguan, M Indrawattana, N Sookrung, N Tapchaisri, P Yamazaki, S Bodhidatta, L Eampokalap, B Kurazono, H Hayashi, H Nair, GB Takeda, Y Chaicumpa, W AF Na-Ubol, M. Srimanote, P. Chongsa-nguan, M. Indrawattana, N. Sookrung, N. Tapchaisri, P. Yamazaki, S. Bodhidatta, L. Eampokalap, B. Kurazono, H. Hayashi, H. Nair, G. B. Takeda, Y. Chaicumpa, W. TI Hybrid & El Tor variant biotypes of Vibrio cholerae O1 in Thailand SO INDIAN JOURNAL OF MEDICAL RESEARCH LA English DT Article DE Biotypes; El Tor variant; Thailand; Vibrio cholerae ID BANGLADESH; EPIDEMIC; MOZAMBIQUE; STRAINS; SCHEME; BENGAL; INDIA AB Background & objectives: El Tor Vibrio cholerae O1 carrying ctxB(C) trait, so-called El Tor variant that causes more severe symptoms than the prototype El Tor strain, first detected in Bangladesh was later shown to have emerged in India in 1992. Subsequently, similar V cholerae strains were isolated in other countries in Asia and Africa. Thus, it was of interest to investigate the characteristics of V cholerae O1 strains isolated chronologically (from 1986 to 2009) in Thailand. Methods: A total of 330 V. cholerae O1 Thailand strains from hospitalized patients with cholera isolated during 1986 to 2009 were subjected to conventional biotyping i.e., susceptibility to polymyxin B, chicken erythrocyte agglutination (CCA) and Voges-Proskauer (VP) test. The presence of ctxA, ctxB, zot, ace, toxR, tcpA(C), tcpA(E), hlyA(C) and hlyA(E) were examined by PCR. Mismatch amplification mutation assay (MAMA) - and conventional- PCRs were used for differentiating ctxB and rstR alleles. Results: All 330 strains carried the El Tor virulence gene signature. Among these, 266 strains were typical El Tor (resistant to 50 units of polymyxin B and positive for CCA and VP test) while 64 had mixed classical and El Tor phenotypes (hybrid biotype). Combined MAMA-PCR and the conventional biotyping methods revealed that 36 strains of 1986-1992 were either typical El Tor, hybrid, El Tor variant or unclassified biotype. The hybrid strains were present during 1986-2004. El Tor variant strains were found in 1992, the same year when the typical El Tor strains disappeared. All 294 strains of 1993-2009 carried ctxB(C); 237 were El Tor variant and 57 were hybrid. Interpretation & conclusions: In Thailand, hybrid V cholerae O1 (mixed biotypes), was found since 1986. Circulating strains, however, are predominantly El Tor variant (El Tor biotype with ctxB(C)). C1 [Chaicumpa, W.] Mahidol Univ, Dept Parasitol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. [Na-Ubol, M.; Chongsa-nguan, M.; Indrawattana, N.] Mahidol Univ, Dept Microbiol & Immunol, Fac Trop Med, Bangkok 10700, Thailand. [Srimanote, P.; Tapchaisri, P.] Thammasat Univ, Fac Allied Hlth Sci, Pathum Thani, Thailand. [Sookrung, N.] Mahidol Univ, Off Res & Dev, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. [Yamazaki, S.] Osaka Prefecture Univ, Dept Vet Sci, Grad Sch Life & Environm Sci, Osaka, Japan. [Bodhidatta, L.] US Army Component, Dept Enter Dis, Armed Force Res Inst Med Sci, Bangkok, Thailand. [Eampokalap, B.] Bamrasnaradura Inst, Nonthaburi, Thailand. [Kurazono, H.] Obihiro Univ Agr & Vet Med, Dept Anim & Food Hyg, Hokkaido, Japan. [Hayashi, H.] Chugoku Gakuen Univ, Dept Microbiol & Nutr, Okayama, Japan. [Nair, G. B.; Takeda, Y.] Natl Inst Cholera & Enter Dis, Kolkata, India. RP Chaicumpa, W (reprint author), Mahidol Univ, Dept Parasitol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. EM tmwcc@mahidol.ac.th FU Thailand Office of Higher Education Commission (CHE) through Center for Biopharmaceutical Development and Innovative Therapy, Mahidol University; CHE [RG 490329]; Thailand Research Fund (TRF) [DPG5380001]; Japan Health Science Foundation, Japan FX The work was co-supported by the National Research University project of Thailand Office of Higher Education Commission (CHE) through Center for Biopharmaceutical Development and Innovative Therapy, Mahidol University and CHE RG 490329, the Thailand Research Fund (TRF; DPG5380001) and the Japan Health Science Foundation, Japan. P. Srimanote, N. Indrawattana, and N. Sookrung received research support from TRF. NR 26 TC 13 Z9 18 U1 0 U2 2 PU INDIAN COUNCIL MEDICAL RES PI NEW DELHI PA PO BOX 4911 ANSARI NAGAR, NEW DELHI 110029, INDIA SN 0971-5916 J9 INDIAN J MED RES JI Indian J. Med. Res. PD APR PY 2011 VL 133 IS 4 BP 387 EP 394 PG 8 WC Immunology; Medicine, General & Internal; Medicine, Research & Experimental SC Immunology; General & Internal Medicine; Research & Experimental Medicine GA 759KC UT WOS:000290239100006 PM 21537091 ER PT J AU Resio, DT Long, CE Perrie, W AF Resio, Donald T. Long, Charles E. Perrie, William TI The Role of Nonlinear Momentum Fluxes on the Evolution of Directional Wind-Wave Spectra SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID GENERATED GRAVITY-WAVES; EQUILIBRIUM RANGE; OCEAN WAVES; ENERGY-TRANSFER; GROWTH; SIMILARITY; SEAS; TERM AB It has long been known that nonlinear wave-wave interactions produce stationary solutions related to constant energy flux through the equilibrium range when a deep-water spectrum follows an f(-4) form, as has been verified in numerical studies in which spectra follow a constant angular spreading distribution. This paper shows that, although energy fluxes through such spectra remain essentially constant, momentum fluxes do not. On the other hand, if the angular distribution of a spectrum is allowed to behave in a manner consistent with observations, both the energy flux and the momentum flux tend to remain constant through a major portion of the spectrum. Thus, it appears that directional distributions of energy within wind-wave spectra adjust to a form consistent with nondivergent nonlinear fluxes, suggesting that these fluxes likely play a very prominent role in the evolution of directional spectra during wave generation. C1 [Resio, Donald T.; Long, Charles E.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Perrie, William] Fisheries & Oceans Canada, Bedford Inst Oceanog, Dartmouth, NS B2Y 4A2, Canada. RP Resio, DT (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM donald.t.resio@usace.army.mil FU U.S. Army Corps of Engineers; Canadian Panel on Energy Research and Development (PERD); U.S. Office of Naval Research (ONR) FX Support for this research comes from the U.S. Army Corps of Engineers, the Canadian Panel on Energy Research and Development (PERD-Offshore Environmental Factors Program), and the U.S. Office of Naval Research (ONR) through the National Oceanographic Partnership Program. NR 48 TC 4 Z9 4 U1 0 U2 8 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD APR PY 2011 VL 41 IS 4 BP 781 EP 801 DI 10.1175/2010JPO4545.1 PG 21 WC Oceanography SC Oceanography GA 757AV UT WOS:000290057200008 ER PT J AU Tubaro, A Del Favero, G Beltramo, D Ardizzone, M Forino, M De Bortoli, M Pelin, M Poli, M Bignami, G Ciminiello, P Sosa, S AF Tubaro, A. Del Favero, G. Beltramo, D. Ardizzone, M. Forino, M. De Bortoli, M. Pelin, M. Poli, M. Bignami, G. Ciminiello, P. Sosa, S. TI Acute oral toxicity in mice of a new palytoxin analog: 42-Hydroxy-palytoxin SO TOXICON LA English DT Article DE 42-Hydroxy-palytoxin (42-OH-PLTX); Algal toxins; Acute oral toxicity; Mice; Light microscopy ID PUTATIVE PALYTOXIN; MASS-SPECTROMETRY; OSTREOPSIS-OVATA; OSTREOCIN-D; IDENTIFICATION; OUTBREAK; TOXIN; CRAB AB The acute oral toxicity of a new palytoxin congener, 42-hydroxy-palytoxin (42-OH-PLTX), was investigated in female CD-1 mice. The toxin (300-1697 mu g/kg), administered by gavage, induced scratching, jumping, respiratory distress, cyanosis, paralysis and death of mice, with an LD(50) of 651 mu g/kg (95% confidence limits: 384-1018 mu g/kg) within 24 h. Hematoclinical analyses showed increased plasma levels of lactate dehydrogenase and aspartate-aminotransferase at doses of 600 mu g/kg and above, as well as of alanine-aminotransferase, creatine phosphokinase and potassium ions at >= 848 mu g/kg. Histology revealed inflammatory lesions in the non-glandular area of the stomach of mice that survived up to 24 h after gavage (424-1200 mu g/kg). Although no histological alterations were seen in skeletal and cardiac muscles, changes in some plasma biomarkers (creatine phosphokinase, lactate dehydrogenase) suggested involvement of these tissues in 42-OH-PLTX oral toxicity, in agreement with epidemiological data on seafood poisonings ascribed to palytoxins. Complete recovery of the tissue and hematological changes was observed two weeks post-exposure. Furthermore, 42-OH-PLTX induced in vitro delayed erythrocyte hemolysis at concentrations similar to those of nix (EC(50) = 7.6 and 13.2 x 10(-12) M, respectively). This hemolysis could be completely neutralized by a monoclonal anti-PLTX antibody. The in vivo data, together with the in vitro data recorded for 42-OH-PLTX, seem to indicate Na(+)/K(+)-ATPase as one of the key cellular targets of this toxin. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Tubaro, A.; Del Favero, G.; De Bortoli, M.; Pelin, M.; Sosa, S.] Univ Trieste, Dipartimento Mat & Risorse Nat, I-34127 Trieste, Italy. [Beltramo, D.; Ardizzone, M.] Ist Ric Biomed Antoine Marxer RBM SpA, I-10010 Colleretto Giacosa, TO, Italy. [Forino, M.; Ciminiello, P.] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy. [Poli, M.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Bignami, G.] PanThera Biopharma, Aiea, HI 96701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dipartimento Mat & Risorse Nat, Via A Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it RI Forino, Martino/F-4648-2010; OI Forino, Martino/0000-0001-8036-3546 FU Italian Ministry of Education, University and Research (MIUR) [2007FXSCL2 005]; Friuli Venezia Giulia Region - Direzione Centrale Risorse Agricole, Naturali e Forestali FX This work was supported by the Italian Ministry of Education, University and Research (MIUR) [grant number 2007FXSCL2 005] and Friuli Venezia Giulia Region - Direzione Centrale Risorse Agricole, Naturali e Forestali. The authors thank Dr. Sergio Peano for the stimulating discussion. NR 34 TC 23 Z9 23 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 2011 VL 57 IS 5 BP 755 EP 763 DI 10.1016/j.toxicon.2011.02.009 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 758RQ UT WOS:000290184300014 PM 21333670 ER PT J AU Barton, NR Bernier, JV Becker, R Arsenlis, A Cavallo, R Marian, J Rhee, M Park, HS Remington, BA Olson, RT AF Barton, N. R. Bernier, J. V. Becker, R. Arsenlis, A. Cavallo, R. Marian, J. Rhee, M. Park, H. -S. Remington, B. A. Olson, R. T. TI A multiscale strength model for extreme loading conditions SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TANTALUM-TUNGSTEN ALLOYS; STRAIN-RATE DEFORMATION; DISLOCATION MECHANICS; ATOMISTIC SIMULATION; CONSTITUTIVE MODEL; SINGLE-CRYSTALS; BCC TANTALUM; PLASTICITY; PRESSURE; LOCALIZATION AB We present a multiscale strength model in which strength depends on pressure, strain rate, temperature, and evolving dislocation density. Model construction employs an information passing paradigm to span from the atomistic level to the continuum level. Simulation methods in the overall hierarchy include density functional theory, molecular statics, molecular dynamics, dislocation dynamics, and continuum based approaches. Given the nature of the subcontinuum simulations upon which the strength model is based, the model is particularly appropriate to strain rates in excess of 10(4) s(-1). Strength model parameters are obtained entirely from the hierarchy of simulation methods to obtain a full strength model in a range of loading conditions that so far has been inaccessible to direct measurement of material strength. Model predictions compare favorably with relevant high energy density physics (HEDP) experiments that have bearing on material strength. The model is used to provide insight into HEDP experimental observations and to make predictions of what might be observable using dynamic x-ray diffraction based experimental methods. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3553718] C1 [Barton, N. R.; Bernier, J. V.; Arsenlis, A.; Cavallo, R.; Marian, J.; Rhee, M.; Park, H. -S.; Remington, B. A.] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. [Becker, R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Olson, R. T.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. RP Barton, NR (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. EM barton22@llnl.gov RI Davidi, Gal/E-7089-2011; Becker, Richard/I-1196-2013 FU U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC5207NA27344 (LLNL-JRNL-448591)]; ASC/PEM program FX This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC5207NA27344 (LLNL-JRNL-448591). Funding through the ASC/PEM program is gratefully acknowledged. NR 58 TC 60 Z9 60 U1 3 U2 45 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2011 VL 109 IS 7 AR 073501 DI 10.1063/1.3553718 PG 12 WC Physics, Applied SC Physics GA 755PY UT WOS:000289949000028 ER PT J AU Hsu, MK Lee, TN Szu, H AF Hsu, Ming Kai Lee, Ting N. Szu, Harold TI Re-establish the time-order across sensors of different modalities SO OPTICAL ENGINEERING LA English DT Article DE long exposure; time-order; associate a video submanifold; acoustic manifold ID NONLINEAR DIMENSIONALITY REDUCTION; FRAMEWORK AB Modern cameras can cut passengers' faces into boxes in 0.04 s per frame in parallel without time stamps. Unfortunately, that creates random storage without the tracking capability, and one can no longer meet the 5 W's challenge-"who speaks what, where and when." We develop a time-order reconstruction methodology which sorts the boxes as follows. i. A morphological image preprocessing to overcome the facial changes is based on the peripheral invariance of a human visual system when focusing on a maximum overlapping central region. ii. Replacing the Wiener matched filter desired output with an averaged but blurred long exposure, one can select the best matched sharp short exposures called the anchor faces beta's. iii. The time-order neighborhood chaining is done by an iterative self-affirmation logic that demands amutually agreed-upon minimum distance: whether or not the two nearest neighbors of beta, namely face A and face C, also consider beta to be their two nearest neighbors. The reconstruction procedure mathematically amounts to a product of two triple correlation functions sharing an intermediate state. We have thus demonstrated the time-order helps us associate a video submanifold with the acoustic manifold that solves the 5 W's challenge. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3562322] C1 [Hsu, Ming Kai; Lee, Ting N.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20002 USA. [Szu, Harold] USA, Night Visi& Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Hsu, MK (reprint author), George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20002 USA. EM mkhsu@gwmail.gwu.edu NR 32 TC 1 Z9 1 U1 2 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD APR PY 2011 VL 50 IS 4 AR 047002 DI 10.1117/1.3562322 PG 15 WC Optics SC Optics GA 756QG UT WOS:000290028900029 ER PT J AU Mentzer, MA Ghosh, CL Guo, B Brewer, K Nicolai, R Herr, D Lubking, C Ojason, N Tangradi, E Tarpine, H AF Mentzer, Mark A. Ghosh, Chuni L. Guo, Baiming Brewer, Kristopher Nicolai, Robin Herr, Douglas Lubking, Carl Ojason, Neil Tangradi, Edward Tarpine, Howard TI Feasibility analysis and demonstration of high-speed digital imaging using micro-arrays of vertical cavity surface-emitting lasers SO OPTICAL ENGINEERING LA English DT Article DE high brightness imaging; laser illumination; high speed videography; fireball filtering; background discrimination AB Previous laser illumination systems at Aberdeen Proving Ground and elsewhere required complex pulse timing, extensive cooling, large-scale laser systems (frequency-doubled flash-pumped Nd:YAG, Cu-vapor, Q-switched ruby), making them difficult to implement for range test illumination in high speed videography. Requirements to illuminate through the self-luminosity of explosive events motivate the development of a high brightness imaging technique obviating the limitations of previous attempts. A lensed vertical cavity surface-emitting laser array is proposed and implemented with spectral filtering to effectively remove self-luminosity and the fireball from the image, providing excellent background discrimination in a variety of range test scenarios. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI:10.1117/1.3570678] C1 [Mentzer, Mark A.] USA, Res Lab, Survivabil Lethal Anal Directorate, RDRL SLB D, Aberdeen Proving Ground, MD 21005 USA. [Ghosh, Chuni L.; Guo, Baiming] Princeton Optron, Mercerville, NJ 08619 USA. [Brewer, Kristopher; Nicolai, Robin] USA, Aberdeen Test Ctr, Tech Imaging Div, Aberdeen Proving Ground, MD 21005 USA. [Herr, Douglas; Lubking, Carl; Ojason, Neil; Tangradi, Edward; Tarpine, Howard] Jacobs ATSS, Aberdeen Proving Ground, MD 21005 USA. RP Mentzer, MA (reprint author), USA, Res Lab, Survivabil Lethal Anal Directorate, RDRL SLB D, Aberdeen Proving Ground, MD 21005 USA. EM mark.mentzer@us.army.mil NR 9 TC 0 Z9 0 U1 1 U2 2 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD APR PY 2011 VL 50 IS 4 AR 043201 DI 10.1117/1.3570678 PG 6 WC Optics SC Optics GA 756QG UT WOS:000290028900005 ER PT J AU Sabatini, JJ Freeman, CT Poret, JC Nagori, AV Chen, G AF Sabatini, Jesse J. Freeman, Cathleen T. Poret, Jay C. Nagori, Amita V. Chen, Gary TI An Examination of Binder Systems and Their Influences on Burn Rates of High-Nitrogen Containing Formulations SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Binders; Energetic Materials; Hand-Held Signals; High-Nitrogen; Pyrotechnics AB The examination of Laminae 4116/Lupersol and Epon 813/Versamid 140 binder systems, and their influences on burn rates of pyrotechnic formulations is described. Laminac 4116/Lupersol-based formulations had shorter burn times and larger heat of explosion values compared to their Epon 813/Versamid 140 counterparts. An understanding of the chemical structures and approximate oxygen balances of these binder systems served to explain their burn time differences when used in pyrotechnic formulations. Bomb calorimetry of Laminac 4116/Lupersol- and Epon 813/Versamid 140-based formulations provided heat of explosion values to further explain the burn time differences of the two binder systems used. C1 [Sabatini, Jesse J.; Freeman, Cathleen T.; Poret, Jay C.; Nagori, Amita V.; Chen, Gary] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Sabatini, JJ (reprint author), USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM jesse.sabatini@us.army.mil FU Environmental Quality Technology (EQT) Program; Ms. Amanda J. Amoroso of the Armament, Research, Development and Engineering Center (ARDEC) FX The Environmental Quality Technology (EQT) Program and Ms. Amanda J. Amoroso of the Armament, Research, Development and Engineering Center (ARDEC) are gratefully acknowledged for funding of this work. The authors thank Dr. Reddy Damavarapu (ARDEC) for his large scale synthesis of strontium bis-(1-methyl-5-nitriminotetrazolate) monohydrate (1). The authors are indebted to Dr. Thomas Klapotke of Ludwig-Maximilian University (LMU) for helpful discussions regarding the chemistry of high-nitrogen energetic compounds. NR 7 TC 12 Z9 12 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD APR PY 2011 VL 36 IS 2 BP 145 EP 150 DI 10.1002/prep.201000061 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 757YH UT WOS:000290124100008 ER PT J AU Perliger, A Pedahzur, A AF Perliger, Arie Pedahzur, Ami TI RESPONSE TO "SOCIAL NETWORK ANALYSIS IN THE STUDY OF TERRORISM AND POLITICAL VIOLENCE" RESPONSE SO PS-POLITICAL SCIENCE & POLITICS LA English DT Editorial Material C1 [Perliger, Arie] US Mil Acad, West Point, NY 10996 USA. [Pedahzur, Ami] Univ Texas Austin, Austin, TX 78712 USA. RP Perliger, A (reprint author), US Mil Acad, West Point, NY 10996 USA. OI Pedahzur, Ami/0000-0002-0925-4993 NR 0 TC 0 Z9 0 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-0965 J9 PS-POLIT SCI POLIT JI PS-Polit. Sci. Polit. PD APR PY 2011 VL 44 IS 2 BP 238 EP 240 PG 3 WC Political Science SC Government & Law GA 753TT UT WOS:000289803300002 ER PT J AU Feng, WJ Gazonas, GA Hopkins, DA Pan, E AF Feng, W. J. Gazonas, G. A. Hopkins, D. A. Pan, E. TI A second-order theory for piezoelectricity with 6mm and m3 crystal classes SO SMART MATERIALS & STRUCTURES LA English DT Article ID WAVE PROPAGATION; ALPHA-QUARTZ; CONSTANTS; EQUATIONS AB The present paper concentrates on the basic equations of three-dimensional problems for nonlinear piezoelectric materials of hexagonal systems with symmetry class 6mm and of cubic systems with symmetry class m3. Emphasis is placed on developing the nonlinear constitutive relations between extended traction (including elastic stress and polarization) and extended strain (including elastic strain and electric field). The corresponding one-dimensional mathematical models for piezoelectric ceramic with symmetry classes 6mm and m3 are also given. Numerical examples are also carried out for the impact problem to show the important effect of the piezoelectric nonlinearity on the stress wave. Therefore, the derived concise equations can directly be applied to evaluate the nonlinear piezoelectric effects of piezoelectricity by the nonlinear finite element method. C1 [Pan, E.] Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. [Gazonas, G. A.; Hopkins, D. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Feng, W. J.] Shijiazhuang Tiedao Univ, Dept Engn Mech, Shijiazhuang 050043, Peoples R China. RP Pan, E (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011; OI Pan, Ernian/0000-0001-6640-7805; Gazonas, George/0000-0002-2715-016X FU Natural Science Fund of China [10772123]; AFOSR [FA9550-06-1-0317] FX Partial support from the Natural Science Fund of China (10772123) and AFOSR FA9550-06-1-0317 is acknowledged. NR 27 TC 3 Z9 3 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD APR PY 2011 VL 20 IS 4 AR 045011 DI 10.1088/0964-1726/20/4/045011 PG 8 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA 755YB UT WOS:000289975900012 ER PT J AU Rueda, LM Pecor, JE Harrison, BA AF Rueda, L. M. Pecor, J. E. Harrison, B. A. TI Updated distribution records for Anopheles vagus (Diptera: Culicidae) in the Republic of Philippines, and considerations regarding its secondary vector roles in Southeast Asia SO TROPICAL BIOMEDICINE LA English DT Article ID PLASMODIUM-FALCIPARUM; SUBGENUS CELLIA; FLORES-ISLAND; MOSQUITOS; MALARIA; INDONESIA; VIVAX AB Distribution records for Anopheles (Cellia) vagus in the Republic of the Philippines were updated, including recent collection and museum records from Luzon and Visayas Provinces. Larval habitats (e.g. rice paddies, irrigation and drainage ditches), associated species, and the vector potential of this species were also noted. C1 [Rueda, L. M.; Pecor, J. E.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Harrison, B. A.] N Carolina Dept Environm & Nat Resources, Winston Salem, NC 27107 USA. RP Rueda, LM (reprint author), Smithsonian Inst, Museum Support Ctr MRC 534, Walter Reed Biosystemat Unit, 4210 Silver Hill Rd, Suitland, MD 20746 USA. EM ruedapol@si.edu NR 40 TC 7 Z9 7 U1 1 U2 3 PU MALAYSIAN SOC PARASITOLOGY TROPICAL MEDICINE PI KUALA LUMPUR PA C/O INST MEDICAL REEARCH, JALAN PAHANG, KUALA LUMPUR, 50588, MALAYSIA SN 0127-5720 J9 TROP BIOMED JI Trop. Biomed. PD APR PY 2011 VL 28 IS 1 BP 181 EP 187 PG 7 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 754NR UT WOS:000289862500024 PM 21602785 ER PT J AU Tang, YX Quintana, M Zhang, CL Li, T Sauls, D Putnak, R Alvarado, SC Castro, DJ Matute, ML Lynch, JA AF Tang, Yuxin Quintana, Miguel Zhang, Chunlin Li, Tao Sauls, Daniel Putnak, Robert Carolina Alvarado, Sofia Jeaneth Castro, Dina Luisa Matute, Maria Lynch, Julia A. TI Letter to the editor: molecular genotyping of Dengue Virus Types 2 and 4 from the Guatemalan and Honduran Epidemics of 2007 using the envelope glycoprotein gene SO VIRUS GENES LA English DT Article DE Dengue virus; Serotyping; Sequencing; Phylogenetic analysis ID THAILAND AB Eight serum specimens collected from dengue patients in Guatemala and Honduras during the Central American epidemic of 2007 were analyzed. Virus identification and serotyping performed by a nested RT-PCR assay revealed two DENV-1 isolates from Guatemala, four DENV-2 isolates, two each from Guatemala and Honduras, and two DENV-4 isolates from Honduras. Viral genotyping determined by phylogenetic analysis of the complete envelope gene sequences demonstrated that the DENV-2 isolates from Guatemala and Honduras fell into the American/Asian Genotype III, and were most closely related to DENV-2/NI/BID-V2683-1999 isolated from a dengue case in Nicaragua in 1999; and the DENV-4 F07-076 isolate from Honduras belonged to genotype II, and was most closely related to DENV-4/US/BID-V1093/1998 isolated from Puerto Rico in 1998. Our results suggest that the 2007 dengue outbreaks in Guatemala and Honduras were most likely caused by the re-emergence of earlier, indigenous DENV strains rather than by newly introduced strains and there were at least three serotypes of DENV co-circulating during the 2007 Central American epidemics. C1 [Tang, Yuxin; Zhang, Chunlin; Li, Tao; Sauls, Daniel; Putnak, Robert; Lynch, Julia A.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Quintana, Miguel] USACHPPM S, FSHTX, San Antonio, TX 78234 USA. [Carolina Alvarado, Sofia; Jeaneth Castro, Dina; Luisa Matute, Maria] Lab Nacl Secretaria Salud, Virol Lab, Tegucigalpa, Honduras. RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Chunlin.zhang@us.army.mil FU Army Force Medical Intelligence Company, Department of Defense, Fort Detrick, Maryland, USA FX This research was supported by Army Force Medical Intelligence Company, Department of Defense, Fort Detrick, Maryland, USA. The opinions and assertions contained herein are not to be construed as official or as reflecting the views of the US government. NR 12 TC 4 Z9 4 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD APR PY 2011 VL 42 IS 2 BP 200 EP 203 DI 10.1007/s11262-010-0567-3 PG 4 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 752ZD UT WOS:000289733100006 PM 21234665 ER PT J AU Porrett, P Cui, R Sonnad, S Ottmann, S Drazek, D Hoteit, M Olthoff, K Shaked, A Levine, M AF Porrett, P. Cui, R. Sonnad, S. Ottmann, S. Drazek, D. Hoteit, M. Olthoff, K. Shaked, A. Levine, M. TI Impact of True MELD on Post-Transplant Outcome in Patients Listed with Exception MELD HCC Points SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT American Transplant Congress CY 2011 CL Philadelphia, PA C1 [Porrett, P.; Cui, R.; Sonnad, S.; Drazek, D.; Hoteit, M.; Olthoff, K.; Shaked, A.; Levine, M.] Univ Penn, Philadelphia, PA 19104 USA. [Ottmann, S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RI Levine, Matthew/O-4809-2015 OI Levine, Matthew/0000-0003-4525-5827 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD APR PY 2011 VL 11 SU 2 MA 106 BP 63 EP 63 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 747KJ UT WOS:000289318400106 ER PT J AU Porrett, P Cui, R Sonnad, S Ottmann, S Drazek, D Hoteit, M Olthoff, K Shaked, A Levine, M AF Porrett, P. Cui, R. Sonnad, S. Ottmann, S. Drazek, D. Hoteit, M. Olthoff, K. Shaked, A. Levine, M. TI Prolonged Wait List Time Does Not Negatively Impact Oncologic Outcome in Patients Transplanted with HCC SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT American Transplant Congress CY 2011 CL Philadelphia, PA C1 [Porrett, P.; Cui, R.; Sonnad, S.; Drazek, D.; Hoteit, M.; Olthoff, K.; Shaked, A.; Levine, M.] Univ Penn, Philadelphia, PA 19104 USA. [Ottmann, S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD APR PY 2011 VL 11 SU 2 MA 1492 BP 463 EP 463 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 747KJ UT WOS:000289318401710 ER PT J AU Pulvers, K Nguyen, QB Norman, GJ Cummins, SE Zhu, SH AF Pulvers, Kim Nguyen, Quyen B. Norman, Gregory J. Cummins, Sharon E. Zhu, Shu-Hong TI DEVELOPMENT OF A BRIEF PERCEIVED SUPPORT SCALE FOR HELPER-LED SMOKING CESSATION SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Pulvers, Kim] Cal State San Marcos, San Marcos, CA 92096 USA. [Nguyen, Quyen B.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Cummins, Sharon E.; Zhu, Shu-Hong] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. EM kpulvers@csusm.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2011 VL 41 SU 1 BP S42 EP S42 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 747CK UT WOS:000289297700162 ER PT J AU Fink, CM Maggio, KL AF Fink, Caitlin M. Maggio, Kurt L. TI Angiolymphoid Hyperplasia With Eosinophilia Revisited: Lack of Durable Response to Intralesional Interferon Alfa-2a SO ARCHIVES OF DERMATOLOGY LA English DT Letter ID PULSED DYE-LASER C1 [Fink, Caitlin M.; Maggio, Kurt L.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Fink, CM (reprint author), 7701 Woodmont Ave,Apartment 1008, Bethesda, MD 20814 USA. EM caitlin.fink@us.army.mil NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD APR PY 2011 VL 147 IS 4 BP 507 EP 508 PG 3 WC Dermatology SC Dermatology GA 752FY UT WOS:000289677800024 PM 21482908 ER PT J AU Ryan, MD AF Ryan, Maria Del Pilar TI Monumenta Borgia, vol 7, (1550-1566). Sanctus Franciscus Borgia Quartus Gandiae Dux et Societatis Iesu Praepositus Generalis Tertius (1510-1572) SO CATHOLIC HISTORICAL REVIEW LA English DT Book Review C1 [Ryan, Maria Del Pilar] US Mil Acad, West Point, NY 10996 USA. RP Ryan, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CATHOLIC UNIV AMER PRESS PI WASHINGTON PA 620 MICHIGAN AVENUE NE ADMIN BLDG ROOM 303, WASHINGTON, DC 20064 USA SN 0008-8080 J9 CATHOL HIST REV JI Cathol. Hist. Rev. PD APR PY 2011 VL 97 IS 2 BP 370 EP 372 PG 3 WC History SC History GA 749ET UT WOS:000289447100035 ER PT J AU Amin, R Kumar, H Stevens, E AF Amin, R. Kumar, H. Stevens, E. TI Left Fronto-Temporal lobe dementia caused by Gamma Knife Surgery in an Elderly Woman SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting on the American-Geriatrics-Society CY MAY 11-14, 2011 CL National Harbor, MD SP Amer Geriatr Soc C1 [Amin, R.; Kumar, H.; Stevens, E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2011 VL 59 SU 1 BP S160 EP S161 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 750DJ UT WOS:000289524600466 ER PT J AU Cowan, DN Weber, NS Fisher, JA Bedno, SA Niebuhr, DW AF Cowan, David N. Weber, Natalya S. Fisher, Jared A. Bedno, Sheryl A. Niebuhr, David W. TI Incidence of adult onset schizophrenic disorders in the US Military: Patterns by sex, race and age SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Schizophrenic disorders; Incidence; Adult onset; United States; Military ID ETHNIC-GROUPS; RISK; EPIDEMIOLOGY; PREVALENCE; DISABILITY; PSYCHOSIS AB Background: There are limited data describing the epidemiology of adult-onset schizophrenic disorders in the United States. Although the military is not proportionately comparable in all demographic characteristics to the civilian population, it is drawn from all racial/ethnic subgroups, and members range in age from 17 to > 60 years. We describe the incidence of hospitalization for new onset schizophrenic disorders among military members by sex, race, and age. Methods: Using military inpatient data, we evaluated patterns of initial hospitalizations for schizophrenic disorders among military personnel for 2000-2009, focusing on sex, race, and age. No individual-level data were available. Results: From 2000-2009, 1976 military personnel had a first schizophrenic disorder hospitalization, with an overall incidence rate of 0.14/1000 person-years. There were no consistent changes in rates over time. While overall incidence rates were similar for men and women (incidence rate ratio (IRR) = 1.10), rates were higher among men than women below age 25; after 25-30 rates were higher among women. Incidence was higher among blacks and other racial groups, with IRR = 2.0 and 1.3, respectively. Conclusion: Medical screening of military applicants prevents persons with overt or a reported history of psychosis, and most with serious behavior problems, from enlisting; therefore, first hospitalization is likely to reflect new illness. No pre-military socioeconomic data were available, however, essentially all study subjects were high school graduates; unmeasured differences in socioeconomic status were unlikely to explain the observed results. This report may provide lower bound estimates of the schizophrenic disorder incidence in the United States. (C) 2010 Elsevier B.V. All rights reserved. C1 [Cowan, David N.] Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20910 USA. [Cowan, David N.; Fisher, Jared A.] Allied Technol Grp, Rockville, MD USA. RP Cowan, DN (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM David.Cowan@amedd.army.mil; Natalya.Weber@amedd.army.mil; Jared.Fisher5@us.army.mil; sheryl.ann.bedno@us.army.mil; David.Niebuhr@us.army.mil FU Stanley Medical Research Institute, Bethesda, Maryland; United States Department of the Army FX This work was supported by the Stanley Medical Research Institute, Bethesda, Maryland, and the United States Department of the Army. The study sponsors had no further role in study design, in the collection, analysis and interpretation of data: in the writing of the report: and in the decision to submit the paper for publication. NR 24 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2011 VL 127 IS 1-3 BP 235 EP 240 DI 10.1016/j.schres.2010.12.005 PG 6 WC Psychiatry SC Psychiatry GA 748MQ UT WOS:000289395100036 PM 21227655 ER PT J AU Noh, Y Choi, KK Lee, I Gorsich, D Lamb, D AF Noh, Yoojeong Choi, K. K. Lee, Ikjin Gorsich, David Lamb, David TI Reliability-based design optimization with confidence level under input model uncertainty due to limited test data SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Reliability-based design optimization; Input model uncertainty; Confidence level; Confidence interval; Limited data; Adjusted parameters ID INVERSE ANALYSIS METHOD; DIMENSION REDUCTION; SYSTEMS AB For obtaining a correct reliability-based optimum design, the input statistical model, which includes marginal and joint distributions of input random variables, needs to be accurately estimated. However, in most engineering applications, only limited data on input variables are available due to expensive testing costs. The input statistical model estimated from the insufficient data will be inaccurate, which leads to an unreliable optimum design. In this paper, reliability-based design optimization (RBDO) with the confidence level for input normal random variables is proposed to offset the inaccurate estimation of the input statistical model by using adjusted standard deviation and correlation coefficient that include the effect of inaccurate estimation of mean, standard deviation, and correlation coefficient. C1 [Noh, Yoojeong; Choi, K. K.; Lee, Ikjin] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Gorsich, David; Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM noh@ccad.uiowa.edu; kkchoi@engineering.uiowa.edu; ilee@engineering.uiowa.edu; david.gorsich@us.army.mil; david.lamb@us.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008; Noh, Yoojeong/E-9833-2015 OI Choi, Kyung/0000-0003-2384-6220; FU U.S. Army TARDEC; ARO [W911NF-09-1-0250] FX Research is jointly supported by the Automotive Research Center, which is sponsored by the U.S. Army TARDEC and ARO Project W911NF-09-1-0250. This support is greatly appreciated. NR 31 TC 18 Z9 20 U1 0 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD APR PY 2011 VL 43 IS 4 BP 443 EP 458 DI 10.1007/s00158-011-0620-4 PG 16 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA 752JI UT WOS:000289687000001 ER PT J AU Sondeen, JL Prince, MD Kheirabadi, BS Wade, CE Polykratis, IA de Guzman, R Dubick, MA AF Sondeen, Jill L. Prince, M. Dale Kheirabadi, Bijan S. Wade, Charles E. Polykratis, I. Amy de Guzman, Rodolfo Dubick, Michael A. TI Initial resuscitation with plasma and other blood components reduced bleeding compared to hetastarch in anesthetized swine with uncontrolled splenic hemorrhage SO TRANSFUSION LA English DT Article ID RECEIVING MASSIVE TRANSFUSIONS; DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; HYDROXYETHYL STARCH; FLUID RESUSCITATION; TRAUMA; VOLUME; COAGULOPATHY; SURVIVAL; SHOCK AB BACKGROUND: Damage control resuscitation recommends use of more plasma and less crystalloid as initial resuscitation in treating hemorrhage. The purpose of this study was to evaluate resuscitation with either blood components or conventional fluids on coagulation and blood loss. STUDY DESIGN AND METHODS: Isofluorane-anesthetized, instrumented pigs (eight per group) underwent controlled hemorrhage of 24 mL/kg, 20-minute shock period, splenic injury with 15-minute initial bleeding, and hypotensive fluid resuscitation. Lactated Ringer's (LR) was infused at 45 mL/kg while hetastarch (high-molecular-weight hydroxyethyl starch 6%, Hextend, Hospira, Inc., Lake Forest, IL) and blood component (fresh-frozen plasma [FFP], 1:1 FFP:[red blood cells] RBCs, 1:4 FFP : RBCs, and fresh whole blood [FWB]) were infused at 15 mL/kg. Postresuscitation blood loss (PRBL), hemodynamics, coagulation, hematocrit, and oxygen metabolism were measured postinjury for 5 hours. RESULTS: Resuscitation with any blood component reduced PRBL of 52% to 70% compared to Hextend, with FFP resulting in the lowest PRBL. PRBL with LR (11.5 +/- 3.0 mL/kg) was not significantly different from Hextend (17.9 +/- 2.5 mL/kg) or blood components (range, 5.5 +/- 1.5 to 8.6 +/- 2.6 mL/kg). The volume expansion effect of LR was transient. All fluids produced similar changes in hemodynamics, oxygen delivery, and demand despite the oxygen-carrying capacity of RBC-containing fluids. Compared with other fluids, Hextend produced greater hemodilution and reduced coagulation measures, which could be caused by an indirect dilutional effect or a direct hypocoagulable effect. CONCLUSIONS: These data suggest that blood products as initial resuscitation fluids reduced PRBL from a noncompressible injury compared to Hextend, preserved coagulation, and provided sustained volume expansion. There were no differences on PRBL among RBCs-to-FFP, FWB, or FFP in this nonmassive transfusion model. C1 [Sondeen, Jill L.; Prince, M. Dale; Kheirabadi, Bijan S.; Wade, Charles E.; Polykratis, I. Amy; de Guzman, Rodolfo; Dubick, Michael A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Sondeen, JL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM jill.sondeen@us.army.mil FU US Special Operations Command; US Army Medical Research and Materiel Command FX This study was supported by a grant from the US Special Operations Command and the US Army Medical Research and Materiel Command. NR 46 TC 27 Z9 27 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD APR PY 2011 VL 51 IS 4 BP 779 EP 792 DI 10.1111/j.1537-2995.2010.02928.x PG 14 WC Hematology SC Hematology GA 751PH UT WOS:000289629500018 PM 21091492 ER PT J AU Long, JR Frew, MI Brazaitis, MP AF Long, Jeremiah R. Frew, Michael I. Brazaitis, Michael P. TI Virtual colonoscopy in the US Army: current utilization at the Walter Reed Army Medical Center SO ABDOMINAL IMAGING LA English DT Article DE Virtual colonoscopy; Computed tomography colonography; Colorectal cancer screening; Cancer screening; Colon polyps; Colon cancer AB Virtual colonoscopy (VC), also known as CT colonography, continues to gain momentum worldwide as a safe and accurate alternative to traditional optical colonoscopy (OC) for colorectal cancer (CRC) screening. Within the US Army medical system, VC has experienced sustained growth since the program's inception in 2003. Integral to the success of this screening program has been dedicated radiologists and clinical support staff, collaboration with gastroenterology and an active training program for radiologists. Increasing patient and physician acceptance of the VC program along with radiologist education will ensure continued penetration of this valuable screening tool into the US Army medical system. C1 [Long, Jeremiah R.; Frew, Michael I.; Brazaitis, Michael P.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Long, JR (reprint author), Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. EM jeremiah.r.long@us.army.mil NR 4 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0942-8925 EI 1432-0509 J9 ABDOM IMAGING JI Abdom. Imaging PD APR PY 2011 VL 36 IS 2 BP 149 EP 152 DI 10.1007/s00261-010-9623-7 PG 4 WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging GA 747CA UT WOS:000289296700006 PM 20473668 ER PT J AU Warner, CH Appenzeller, GN Parker, JR Warner, CM Hoge, CW AF Warner, Christopher H. Appenzeller, George N. Parker, Jessica R. Warner, Carolynn M. Hoge, Charles W. TI Effectiveness of Mental Health Screening and Coordination of In-Theater Care Prior to Deployment to Iraq: A Cohort Study SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID LEVEL MILITARY PERSONNEL; FOLLOW-UP; DEPRESSION; RECRUITS; FORCES; WAR AB Objective: The authors assessed the effectiveness of a systematic method of predeployment mental health screening to determine whether screening decreased negative outcomes during deployment in Iraq's combat setting. Method: Primary care providers performed directed mental health screenings during standard predeployment medical screening. If indicated, on-site mental health providers assessed occupational functioning with unit leaders and coordinated in-theater care for those cleared for deployment. Mental health-related clinical encounters and evacuations during the first 6 months of deployment in 2007 were compared for 10,678 soldiers from three screened combat brigades and 10,353 soldiers from three comparable unscreened combat brigades. Results: Of 10,678 soldiers screened, 819 (7.7%, 95% confidence interval [CI]=7.28.2) received further mental health evaluation; of these, 74 (9.0%, 95% CI=7.1-11.0) were not cleared to deploy and 96 (11.7%, 95% CI=9.5-13.9) were deployed with additional requirements. After 6 months, soldiers in screened brigades had significantly lower rates of clinical contacts than did those in unscreened brigades for suicidal ideation (0.4%, 95% CI=0.3-0.5, compared with 0.9%, 95% CI=0.7-1.1), for combat stress (15.7%, 95% CI=15.0-16.4, compared with 22.0%, 95% CI=21.2-22.8), and for psychiatric disorders (2.9%, 95% CI=2.6-3.2, compared with 13.2%, 95% CI=12.5-13.8), as well as lower rates of occupational impairment (0.6%, 95% CI=0.4-0.7, compared with 1.8%, 95% CI=1.5-2.1) and air evacuation for behavioral health reasons (0.1%, 95% CI=0.1-0.2, compared with 0.3%, 95% CI=0.2-0.4). Conclusions: Predeployment mental health screening was associated with significant reductions in occupationally impairing mental health problems, medical evacuations from Iraq for mental health reasons, and suicidal ideation. This predeployment screening process provides a feasible system for screening soldiers and coordinating mental health support during deployment. C1 [Warner, Christopher H.] Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. USA, Med Act Alaska, Ft Wainwright, AK USA. Winn Army Community Hosp, Ft Stewart, GA USA. Munson Army Hlth Clin, Ft Leavenworth, KS USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Warner, CH (reprint author), Command & Gen Staff Coll, 100 Stimson Ave, Ft Leavenworth, KS 66027 USA. EM christopher.h.warner@us.army.mil NR 26 TC 38 Z9 38 U1 0 U2 5 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X EI 1535-7228 J9 AM J PSYCHIAT JI Am. J. Psychiat. PD APR PY 2011 VL 168 IS 4 BP 378 EP 385 DI 10.1176/appi.ajp.2010.10091303 PG 8 WC Psychiatry SC Psychiatry GA 746KM UT WOS:000289245500009 PM 21245086 ER PT J AU Moore, HM Kelly, A Jewell, SD McShane, LM Clark, DP Greenspan, R Hainaut, P Hayes, DF Kim, P Mansfield, E Potapova, O Riegman, P Rubinstein, Y Seijo, E Somiari, S Watson, P Weier, HU Zhu, C Vaught, J AF Moore, Helen M. Kelly, Andrea Jewell, Scott D. McShane, Lisa M. Clark, Douglas P. Greenspan, Renata Hainaut, Pierre Hayes, Daniel F. Kim, Paula Mansfield, Elizabeth Potapova, Olga Riegman, Peter Rubinstein, Yaffa Seijo, Edward Somiari, Stella Watson, Peter Weier, Heinz-Ulrich Zhu, Claire Vaught, Jim TI Biospecimen Reporting for Improved Study Quality SO BIOPRESERVATION AND BIOBANKING LA English DT Article ID PARAFFIN-EMBEDDED TISSUES; FLIGHT-MASS-SPECTROMETRY; APPROACHING CLINICAL PROTEOMICS; GENE-EXPRESSION PROFILES; NEEDLE-ASPIRATION BIOPSY; HUMAN POSTMORTEM TISSUES; LONG-TERM STORAGE; MESSENGER-RNA; HUMAN BRAIN; MICROARRAY ANALYSIS AB Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The Biospecimen Reporting for Improved Study Quality guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected. C1 [Moore, Helen M.; Vaught, Jim] NCI, Off Biorepositories & Biospecimen Res, NIH, Dept Hlth & Human Serv, Rockville, MD 20852 USA. [Kelly, Andrea] Rose Li & Associates Inc, Brookeville, MD USA. [Jewell, Scott D.] Van Andel Res Inst, Program Biospecimen Sci, Grand Rapids, MI USA. [McShane, Lisa M.] NCI, Biometr Res Branch, Rockville, MD USA. [Clark, Douglas P.] Johns Hopkins Univ Hosp, Div Cytopathol, Baltimore, MD 21287 USA. [Greenspan, Renata] Walter Reed Army Med Ctr, USMCI, Washington, DC 20307 USA. [Hainaut, Pierre] WHO, Int Agcy Res Canc, Lyon, France. [Hayes, Daniel F.] Univ Michigan, Ctr Comprehens Canc, Breast Canc Res, Breast Oncol Program, Ann Arbor, MI 48109 USA. [Kim, Paula] TRAC Translating Res Communities, Green Cove Springs, FL USA. [Mansfield, Elizabeth] Ctr Devices & Radiol Hlth, CDRH Off Vitro Diagnost Device Evaluat & Safety, Silver Spring, MD USA. [Potapova, Olga] Cureline Inc, San Francisco, CA USA. [Riegman, Peter] Erasmus MC Tissue Bank, Rotterdam, Netherlands. [Rubinstein, Yaffa] NIH, Off Rare Dis Res, Rockville, MD USA. [Seijo, Edward] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Somiari, Stella] Windber Res Inst, Windber, PA USA. [Watson, Peter] Univ British Columbia, Dept Pathol & Lab Med, Victoria, BC, Canada. [Weier, Heinz-Ulrich] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Zhu, Claire] NCI, Canc Prevent Div, Rockville, MD USA. RP Vaught, J (reprint author), NCI, Off Biorepositories & Biospecimen Res, NIH, Dept Hlth & Human Serv, 11400 Rockville Pike,Suite 700, Rockville, MD 20852 USA. EM vaughtj@mail.nih.gov RI Hainaut, Pierre /B-6018-2012 OI Hainaut, Pierre /0000-0002-1303-1610 FU NCI, National Institutes of Health [HHSN261200800001E]; NIH [CA136685]; Lawrence Berkeley National Laboratory [DE-AC002-05CH11231] FX This project has been funded in whole or in part with Federal Funds from the NCI, National Institutes of Health, under contract no. HHSN261200800001E and by NIH grant CA136685 (HUW) carried out at the Lawrence Berkeley National Laboratory under contract DE-AC002-05CH11231. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, and mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. NR 81 TC 49 Z9 49 U1 2 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1947-5535 J9 BIOPRESERV BIOBANK JI Biopreserv. Biobank. PD APR PY 2011 VL 9 IS 1 BP 57 EP 70 DI 10.1089/bio.2010.0036 PG 14 WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology SC Cell Biology; Chemistry; Medical Laboratory Technology GA 751KS UT WOS:000289617000010 ER PT J AU Raymundo, EM Rice, KR Chen, YM Zhao, JX Brassell, SA AF Raymundo, Eliza M. Rice, Kevin R. Chen, Yongmei Zhao, Jinxiu Brassell, Stephen A. TI Prostate cancer in Asian Americans: incidence, management and outcomes in an equal access healthcare system SO BJU INTERNATIONAL LA English DT Article DE Asian American; prostate cancer; prostate cancer screening ID UNITED-STATES; RADICAL PROSTATECTOMY; CHINESE-AMERICANS; RISK-FACTORS; SURVIVAL; RACE; ACCULTURATION; MORTALITY; DIAGNOSIS; JAPANESE AB What's known on the subject? and What does the study add? While epidemiological studies have shown a significantly lower incidence of adenocarcinoma of the prostate in Asia than the United States, several studies have demonstrated that Asian Americans present with more advanced stages, higher tumour grades, and worse mortality-incidence ratios than Caucasian Americans. This study, conducted in an equal access military healthcare system, reveals improved pathological and survival outcomes in Asian Americans compared to other races. This may indicate that worsened outcomes previously reported among Asian Americans diagnosed with adenocarcinoma of the prostate may be related to access to care, language barriers, socioeconomic status, or cultural factors. OBJECTIVE center dot To characterize the incidence, management and clinicopathological characteristics of prostate cancer (CaP) in a population of Asian Americans undergoing mandatory annual screening in an equal access healthcare system. PATIENTS AND METHODS center dot Men registered into the military-based Center for Prostate Disease Research multi-institutional database from 1989-2007 with biopsy-proven CaP and categorized as Asian American, Caucasian or African American were included. center dot Demographic information, treatment modality, clinicopathological characteristics and outcomes were compared. RESULTS center dot In total, there were 10 964 patients; 583 (5.3%) were Asian Americans. Asian Americans had lower clinical stage (P < 0.001) but worse biopsy grade (P < 0.001) than other groups. They were more likely to choose radical prostatectomy (RP) (P < 0.001) and showed a higher percentage of organ-confined disease (P < 0.001). center dot Asian Americans had improved biochemical recurrence free (P < 0.01) and overall survival (P < 0.001) rates compared to African Americans or Caucasians treated with RP or external radiation therapy. CONCLUSIONS center dot Asian Americans with CaP treated in an equal access healthcare system have improved pathological outcomes and survival characteristics compared to other races. center dot Asian ethnicity's negative impact on survival noted by others appears to be the result of factors other than the tumour's intrinsic behaviour, such as language barriers, socioeconomic status and cultural norms. C1 [Rice, Kevin R.; Brassell, Stephen A.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. [Raymundo, Eliza M.; Chen, Yongmei; Zhao, Jinxiu; Brassell, Stephen A.] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Bethesda, MD USA. RP Rice, KR (reprint author), Walter Reed Army Med Ctr, Urol Serv, 6900 Georgia Ave NW,Bldg 2,Ward 56, Washington, DC 20307 USA. EM kevin.rice@amedd.army.mil NR 24 TC 13 Z9 13 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1464-4096 J9 BJU INT JI BJU Int. PD APR PY 2011 VL 107 IS 8 BP 1216 EP 1222 DI 10.1111/j.1464-410X.2010.09685.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 749RH UT WOS:000289486300006 PM 21040364 ER PT J AU Guandalini, GS Zhang, L Fornero, E Centeno, JA Mokashi, VP Ortiz, PA Stockelman, MD Osterburg, AR Chapman, GG AF Guandalini, Gustavo S. Zhang, Lingsu Fornero, Elisa Centeno, Jose A. Mokashi, Vishwesh P. Ortiz, Pedro A. Stockelman, Michael D. Osterburg, Andrew R. Chapman, Gail G. TI Tissue Distribution of Tungsten in Mice Following Oral Exposure to Sodium Tungstate SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID DIABETIC-RATS; NORMALIZATION; CELLS AB Heavy metal tungsten alloys have replaced lead and depleted uranium in many munitions applications, due to public perception of these elements as environmentally unsafe. Tungsten materials left in the environment may become bioaccessible as tungstate, which might lead to population exposure through water and soil contamination. Although tungsten had been considered a relatively inert and toxicologically safe material, recent research findings have raised concerns about possible deleterious health effects after acute and chronic exposure to this metal. This investigation describes tissue distribution of tungsten in mice following oral exposure to sodium tungstate. Twenty-four 6-9 weeks-old C57BL/6 laboratory mice were exposed to different oral doses of sodium tungstate (0, 62.5, 125, and 200 mg/kg/d) for 28 days, and after one day, six organs were harvested for trace element analysis with inductively coupled plasma mass spectrometry (ICP-MS). Kidney, liver, colon, bone, brain, and spleen were analyzed by sector-field high-resolution ICP-MS. The results showed increasing tungsten levels in all organs with increased dose of exposure, with the highest concentration found in the bones and the lowest concentration found in brain tissue. Gender differences were noticed only in the spleen (higher concentration of tungsten in female animals), and increasing tungsten levels in this organ were correlated with increased iron levels, something that was not observed for any other organ or either of the two other metals analyzed (nickel and cobalt). These findings confirmed most of what has been published on tungsten tissue distribution; they also showed that the brain is relatively protected from oral exposure. Further studies are necessary to clarify the findings in splenic tissue, focusing on possible immunological effects of tungsten exposure. C1 [Guandalini, Gustavo S.; Zhang, Lingsu; Fornero, Elisa; Centeno, Jose A.] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Div Biophys Toxicol, Washington, DC 20306 USA. [Mokashi, Vishwesh P.; Ortiz, Pedro A.; Stockelman, Michael D.] USN, Hlth Res Ctr Detachment, Environm Hlth Effects Lab, Wright Patterson AFB, OH USA. [Osterburg, Andrew R.] Shriners Hosp Children, Cincinnati, OH USA. [Chapman, Gail G.] USA, Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD USA. RP Centeno, JA (reprint author), Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Div Biophys Toxicol, Washington, DC 20306 USA. EM jose.a.centeno@us.army.mil FU Office of Naval Research work unit [60862]; Naval Health Research Center Detachment - Environmental Health Effects Laboratory [N4181709MP9T018] FX This work has been funded by a grant from the Office of Naval Research work unit 60862 and by an Interservice Support Agreement (ISSA) from the Naval Health Research Center Detachment - Environmental Health Effects Laboratory (N4181709MP9T018). NR 24 TC 22 Z9 22 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD APR PY 2011 VL 24 IS 4 BP 488 EP 493 DI 10.1021/tx200011k PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 749WB UT WOS:000289500800008 PM 21375269 ER PT J AU Lettieri, CF Lettieri, CJ Carter, K AF Lettieri, Christine F. Lettieri, Christopher J. Carter, Kevin TI Does Home Sleep Testing Impair Continuous Positive Airway Pressure Adherence in Patients With Obstructive Sleep Apnea? SO CHEST LA English DT Article ID APNEA/HYPOPNEA SYNDROME; SUBSEQUENT COMPLIANCE; HYPOPNEA SYNDROME; CPAP; POLYSOMNOGRAPHY; DIAGNOSIS; THERAPY; STANDARD; EFFICACY; TRIAL AB Background: The increasing recognition of obstructive sleep apnea (OSA) and demand for poly-somnography has created a need for home sleep testing (HST) using unattended diagnostic and titration studies. Although these studies increase access to care and reduce cost, the limited interaction with sleep laboratories may negatively affect positive airway pressure (PAP) adherence. We sought to determine the difference in PAP use between HST and traditional in-laboratory studies. Methods: This observational cohort study included 210 patients with OSA classified into three equal groups. Following preestablished guidelines, group 1 underwent unattended, type III home diagnostic and unattended home auto-adjustable PAP (APAP) titrations; group 2 underwent in-laboratory, type I diagnostic and continuous PAP titration studies; group 3 underwent type I diagnostic and APAP titration studies. Group 1 was primarily managed and educated in a primary care clinic, whereas groups 2 and 3 received extensive education in an academic sleep medicine center. Objective measures of PAP use during the first 4 to 6 weeks of therapy were compared between groups. Results: Type of study and location of care did not affect PAP adherence. PAP was used for 70%, 73%, and 72% of nights in groups 1, 2, and 3, respectively (P=.94). Mean hours of nightly use (4.4 +/- 2.0 h, 4.7 +/- 1.5 h, and 4.6 +/- 1.5 h; P=.98) was also similar. Regular use was observed in 54%, 51%, and 50% of subjects (P=.84). Discontinuation rates were similar between groups. Conclusions: PAP usage did not differ between those undergoing HST vs in-laboratory studies. HST offers a more accessible and cost-effective alternative without compromising therapeutic adherence. CHEST 2011;139(4):849-854 C1 [Lettieri, Christine F.] DeWitt Army Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA. [Lettieri, Christopher J.; Carter, Kevin] Walter Reed Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Washington, DC 20307 USA. [Lettieri, Christine F.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Lettieri, CF (reprint author), DeWitt Army Community Hosp, Dept Family Med, 9501 Farrell Rd, Ft Belvoir, VA 22060 USA. EM Christine.Lettieri@us.army.mil NR 45 TC 7 Z9 7 U1 0 U2 2 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD APR PY 2011 VL 139 IS 4 BP 849 EP 854 DI 10.1378/chest.10-1060 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 750HZ UT WOS:000289538500019 PM 21292757 ER PT J AU Hammers, DW Matheny, RW Sell, C Adamo, ML Walters, TJ Estep, JS Farrar, RP AF Hammers, David W. Matheny, Ronald W., Jr. Sell, Christian Adamo, Martin L. Walters, Thomas J. Estep, J. Scot Farrar, Roger P. TI Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice SO EXPERIMENTAL GERONTOLOGY LA English DT Article DE Tourniquet; Sarcopenia; Muscle regeneration; mTOR; Fox ID GROWTH-FACTOR-I; FOXO TRANSCRIPTION FACTORS; STEM CELL ACTIVATION; UBIQUITIN LIGASES; SATELLITE CELLS; INDUCED INJURY; REGENERATION; RATS; HYPERTROPHY; ATROPHY AB With the advancement of age, skeletal muscle undergoes a progressive decline in mass, function, and regenerative capacity. Previously, our laboratory has reported an age-reduction in recovery and local induction of IGF-I gene expression with age following tourniquet (TK)-induced skeletal muscle ischemia/reperfusion (I/R). In this study, young (6 mo) and old (24-28 mo) mice were subjected to 2 h of TK-induced ischemia of the hindlimb followed by 1, 3, 5, or 7 days of reperfusion. Real time-PCR analysis revealed clear age-related reductions and temporal alterations in the expression of IGF-I and individual IGF-I Ea and Eb splice variants. ELISA verified a reduction of IGF-I peptide with age following 7 day recovery from TK. Western blotting showed that the phosphorylation of Akt, mTOR, and FoxO3, all indicators of anabolic activity, were reduced in the muscles of old mice. These data indicate that an age-related impairment of IGF-I expression and intracellular signaling does exist following injury, and potentially has a role in the impaired recovery of skeletal muscle with age. (C) 2010 Elsevier Inc. All rights reserved. C1 [Hammers, David W.; Farrar, Roger P.] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA. [Matheny, Ronald W., Jr.; Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Matheny, Ronald W., Jr.; Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Sell, Christian] Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USA. [Walters, Thomas J.; Estep, J. Scot] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Farrar, RP (reprint author), Univ Texas Austin, Dept Kinesiol, 1 Univ Stn,D3700, Austin, TX 78712 USA. EM rfarrar@mail.utexas.edu FU U.S. Army Medical Research and Materiel Command [DAMD17-03-1-0735]; NIA [R01 AG026012] FX This work was funded in part by the U.S. Army Medical Research and Materiel Command grant DAMD17-03-1-0735 to RPF and NIA grant R01 AG026012 to MLA. NR 66 TC 12 Z9 13 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0531-5565 EI 1873-6815 J9 EXP GERONTOL JI Exp. Gerontol. PD APR PY 2011 VL 46 IS 4 BP 265 EP 272 DI 10.1016/j.exger.2010.11.002 PG 8 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 751GJ UT WOS:000289605200008 PM 21094246 ER PT J AU Harrison, SA Schenker, S Cusi, K AF Harrison, Stephen A. Schenker, Steven Cusi, Kenneth TI Insulin Sensitizers in Nonalcoholic Steatohepatitis SO HEPATOLOGY LA English DT Letter ID PLACEBO-CONTROLLED TRIAL; PIOGLITAZONE; NASH; RESISTANCE C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Schenker, Steven; Cusi, Kenneth] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM cusi@uthscsa.edu NR 11 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD APR PY 2011 VL 53 IS 4 BP 1404 EP 1405 DI 10.1002/hep.24179 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 748VA UT WOS:000289419600041 PM 21480350 ER PT J AU Sheng, HG Shen, W Wang, HF Fu, DB Pei, YQ Yang, X Wang, F Boroyevich, D Lee, FC Tipton, CW AF Sheng, Honggang Shen, Wei Wang, Hongfang Fu, Dianbo Pei, Yunqing Yang, Xu Wang, Fei Boroyevich, Dushan Lee, Fred C. Tipton, C. Wesley TI Design and Implementation of a High Power Density Three-Level Parallel Resonant Converter for Capacitor Charging Pulsed-Power Supply SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Capacitor charging; power density; pulsed-power supply; resonant converter ID DC-DC CONVERTER; HIGH-VOLTAGE; TOPOLOGY; SYSTEMS; GUNS AB This paper describes the design and implementation of a prototype 30-kW (or 30-kJ/s) pulsed-power supply for capacitor charging. The system operates at 200-kHz maximum switching frequency, which is considerably higher than the conventional practice at this power level, leading to smaller passive components. A high power density of 143 W/in(3) is achieved with the converter operating at a high ambient temperature of 65 degrees C with 90 degrees C cooling oil, by utilizing various technologies on topology, control, devices, passives, and thermal management. The experimental results demonstrate that the converter meets the performance requirements while achieving a high power density. C1 [Sheng, Honggang; Shen, Wei; Wang, Hongfang; Fu, Dianbo; Wang, Fei; Boroyevich, Dushan; Lee, Fred C.] Virginia Polytech Inst & State Univ, Ctr Power Elect Syst, Blacksburg, VA 24060 USA. [Pei, Yunqing; Yang, Xu] Xi An Jiao Tong Univ, Xian 710049, Peoples R China. [Tipton, C. Wesley] USA, Res Lab, Adelphi, MD 20783 USA. RP Sheng, HG (reprint author), Monolith Power Syst Inc, San Jose, CA 95120 USA. EM hgsheng@vt.edu RI fu, dianbo/D-5548-2011 FU U.S. Army Research Laboratory [DAAD19-03-2-0008]; National Science Foundation (NSF) [EEC-9731677] FX Manuscript received December 5, 2010; accepted January 10, 2011. Date of publication March 2, 2011; date of current version April 13, 2011. This work was supported by the U.S. Army Research Laboratory under Grant DAAD19-03-2-0008. This work also made use of the Engineering Research Center Shared Facilities supported by the National Science Foundation (NSF) under NSF Award EEC-9731677 and the CPES Industry Partnership Program. NR 41 TC 22 Z9 29 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 EI 1939-9375 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD APR PY 2011 VL 39 IS 4 BP 1131 EP 1140 DI 10.1109/TPS.2011.2108319 PN 2 PG 10 WC Physics, Fluids & Plasmas SC Physics GA 749OC UT WOS:000289476800016 ER PT J AU Weldon, PJ Carroll, JF Kramer, M Bedoukian, RH Coleman, RE Bernier, UR AF Weldon, Paul J. Carroll, John F. Kramer, Matthew Bedoukian, Robert H. Coleman, Russell E. Bernier, Ulrich R. TI Anointing Chemicals and Hematophagous Arthropods: Responses by Ticks and Mosquitoes to Citrus (Rutaceae) Peel Exudates and Monoterpene Components SO JOURNAL OF CHEMICAL ECOLOGY LA English DT Article DE Citrus; Ectoparasites; Ticks; Mosquitoes; Monoterpenes; Anointing; Repellent ID FUR-RUBBING BEHAVIOR; ESSENTIAL OIL; IXODES-RICINUS; RHIPICEPHALUS-APPENDICULATUS; REPELLENT ACTIVITY; ATELES-GEOFFROYI; CAPUCHIN MONKEYS; CEBUS-CAPUCINUS; CULICIDAE; DIPTERA AB Some birds and mammals roll on or wipe themselves with the fruits or leaves of Citrus spp. or other Rutaceae. These anointing behaviors, as with anointing in general, are thought to function in the topical acquisition of chemicals that deter consumers, including hematophagous arthropods. We measured avoidance and other responses by nymphal lone star ticks (Amblyomma americanum) and adult female yellow fever mosquitoes (Aedes aegypti) to lemon peel exudate and to 24 volatile monoterpenes (racemates and isomers), including hydrocarbons, alcohols, aldehydes, acetates, ketones, and oxides, present in citrus fruits and leaves in order to examine their potential as arthropod deterrents. Ticks allowed to crawl up vertically suspended paper strips onto a chemically treated zone avoided the peel exudate and geraniol, citronellol, citral, carveol, geranyl acetate, alpha-terpineol, citronellyl acetate, and carvone. Ticks confined in chemically treated paper packets subsequently were impaired in climbing and other behaviors following exposure to the peel exudate and, of the compounds tested, most impaired to carveol. Mosquitoes confined in chambers with chemically treated feeding membranes landed and fed less, and flew more, when exposed to the peel exudate than to controls, and when exposed to aldehydes, oxides, or alcohols versus most hydrocarbons or controls. However, attraction by mosquitoes in an olfactometer was not inhibited by either lemon peel exudate or most of the compounds we tested. Our results support the notion that anointing by vertebrates with citrus-derived chemicals deters ticks. We suggest that some topically applied compounds are converted into more potent arthropod deterrents when oxidized on the integument of anointed animals. C1 [Weldon, Paul J.] Smithsonian Conservat Biol Inst, Front Royal, VA 22630 USA. [Carroll, John F.] ARS, USDA, Invas Insect Biocontrol & Behav Lab, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [Kramer, Matthew] ARS, USDA, Biometr Consulting Serv, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [Bedoukian, Robert H.] Bedoukian Res Inc, Danbury, CT 06810 USA. [Coleman, Russell E.] Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. [Bernier, Ulrich R.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. RP Weldon, PJ (reprint author), Smithsonian Conservat Biol Inst, Natl Zool Pk,1500 Remount Rd, Front Royal, VA 22630 USA. EM weldonp@si.edu NR 63 TC 26 Z9 26 U1 5 U2 24 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0098-0331 EI 1573-1561 J9 J CHEM ECOL JI J. Chem. Ecol. PD APR PY 2011 VL 37 IS 4 BP 348 EP 359 DI 10.1007/s10886-011-9922-7 PG 12 WC Biochemistry & Molecular Biology; Ecology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology GA 751LD UT WOS:000289618300003 PM 21409496 ER PT J AU Mallett, DR AF Mallett, Derek R. TI Western Allied Intelligence and the German Military Document Section, 1945-6 SO JOURNAL OF CONTEMPORARY HISTORY LA English DT Article DE Camp Ritchie; Fort Hunt; Reinhard Gehlen; German generals; German Military Document Section; Hill Project AB In the year following the end of the second world war in Europe, various high-ranking Wehrmacht officers agreed to work for a co-ordinated US, British, and Canadian military intelligence operation called the 'Hill Project'. This endeavor, which eventually expanded to almost 200 German prisoners of war, conducted research and analysis of the German Military Document Section at Camp Ritchie, Maryland, and produced over 3600 pages of reports for the Western Allied governments. The Hill Project constitutes a little-known aspect of the interesting postwar relationship between the West and their former enemies. This article examines the main goals of this program and the kind of information these research projects provided to Western Allied military intelligence. It contends that during its operation at Camp Ritchie, the main body of work completed by the Hill Project studied Wehrmacht methods as a means to potentially improve the structure and procedures of the Western Allied armies. Moreover, a select group of the Hill Project prisoners later transferred to Fort Hunt, Virginia, and assisted in preparing a defense of Western Europe against a potential invasion by the Soviet Army. C1 USA, Command & Gen Staff Coll, Redstone Arsenal, AL USA. RP Mallett, DR (reprint author), USA, Command & Gen Staff Coll, Redstone Arsenal, AL USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0022-0094 J9 J CONTEMP HIST JI J. Contemp. Hist. PD APR PY 2011 VL 46 IS 2 BP 383 EP 406 DI 10.1177/0022009410392408 PG 24 WC History SC History GA 746JK UT WOS:000289242200007 ER PT J AU Laflin, KE Morris, CJ Bassik, N Jamal, M Gracias, DH AF Laflin, Kate E. Morris, Christopher J. Bassik, Noy Jamal, Mustapha Gracias, David H. TI Tetherless Microgrippers With Transponder Tags SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Radio-frequency identification (RFID); self-assembly; self-folding; wireless communication ID ACTUATION AB We describe the concept of utilizing tetherless microstructured grippers with attached silicon (Si)-based chips for event-based gripping. Grippers were fabricated using photolithography, and Si chips were bonded to them using a solder-based directed assembly approach. Because we propose the use of these grippers as tags or to attach electronic devices to various surfaces, we also attached commercial microtransponder chips to the grippers as a specific example of an integrated and commercially available electronic device. After assembly, we released grippers with integrated chips from the substrate. Grippers closed upon exposure to heat (> 40 degrees C) or specific chemical environments that softened or degraded a polymer trigger layer incorporated within each hinge. We investigated gripping capabilities of chip-carrying grippers on woven textile fibers and a live caterpillar; these demonstrations were achieved without any attached wires or electrical power. The autonomous thermochemical closure response of the grippers coupled with convenient and secure attachment of wireless microtransponders is a step toward the creation of smart event-based gripping platforms with communication modules. [2010-0228] C1 [Laflin, Kate E.; Bassik, Noy; Jamal, Mustapha; Gracias, David H.] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Morris, Christopher J.] USA, Res Lab, Adelphi, MD 20783 USA. [Bassik, Noy] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. [Gracias, David H.] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA. RP Laflin, KE (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. EM klaflin1@jhu.edu; christopher.morris17@us.army.mil; noy@jhu.edu; mjamal1@jhu.edu; dgracias@jhu.edu RI Gracias, David/A-1942-2010 OI Gracias, David/0000-0003-2735-4725 FU U.S. Army Research Office [W911NF-09-2-0065] FX This work was supported in part by the U.S. Army Research Office under Contract W911NF-09-2-0065. Subject Editor R. T. Howe. NR 20 TC 11 Z9 11 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD APR PY 2011 VL 20 IS 2 BP 505 EP 511 DI 10.1109/JMEMS.2011.2105252 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 745XR UT WOS:000289205400019 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI "The Fall of Satan's Kingdom": Civil-Military Relations and the Union Navy's Attack on Charleston, April 1863 SO JOURNAL OF MILITARY HISTORY LA English DT Article AB During the American Civil War (1861-65) a crisis in civil-military relations culminated in the U.S. Navy's disastrous April 1863 attack by an all-ironclad fleet on the harbor of Charleston, South Carolina. This article examines the serious differences between Union Rear Admiral Samuel Francis Du Pont and Secretary of the Navy Gideon Welles and his assistant Gustavus Fox and sheds light on the relief of a senior military commander and on questionable decisions by key civilian leaders. While Welles and Fox both highly competent administrators do not emerge untarnished from this episode, Du Pont must take the lion's share of the blame for the battle's outcome. C1 US Army War Coll, Carlisle, PA USA. RP Weddle, KJ (reprint author), US Army War Coll, Carlisle, PA USA. NR 59 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2011 VL 75 IS 2 BP 411 EP 439 PG 29 WC History SC History GA 745PL UT WOS:000289178000004 ER PT J AU Kuehn, JT AF Kuehn, John T. TI Untitled response SO JOURNAL OF MILITARY HISTORY LA English DT Letter C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2011 VL 75 IS 2 BP 682 EP 683 PG 2 WC History SC History GA 745PL UT WOS:000289178000047 ER PT J AU Xu, Y Zheng, ZC Wilson, DK AF Xu, Ying Zheng, Z. C. Wilson, D. K. TI A computational study of the effect of windscreen shape and flow resistivity on turbulent wind noise reduction SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID FINITE-DIFFERENCE; SCHEMES; IMPLEMENTATION; FLUCTUATIONS; MECHANISMS; SIMULATION; SURFACES AB In this paper, numerical simulations are used to study the turbulent wind noise reduction effect of microphone windscreens with varying shapes and flow resistivities. Typical windscreen shapes consisting of circular, elliptical, and rectangular cylinders are investigated. A turbulent environment is generated by placing a solid circular cylinder upstream of the microphone. An immersed-boundary method with a fifth-order weighted essentially non-oscillatory scheme is implemented to enhance the simulation accuracy for high-Reynolds number flow around the solid cylinder as well as at the interface between the open air and the porous material comprising the windscreen. The Navier-Stokes equations for incompressible flow are solved in the open air. For the flow inside the porous material, a modified form of the Zwikker-Kosten equation is solved. The results show that, on average, the circular and horizontal ellipse windscreens have similar overall wind noise reduction performance, while the horizontal ellipse windscreen with medium flow resistivity provides the most effective wind noise reduction among all the considered cases. The vertical ellipse windscreen with high flow resistivity, in particular, increases the wind noise because of increased self-generation of turbulence. (C) 2011 Acoustical Society of America. [DOI:10.1121/1.3552886] C1 [Zheng, Z. C.] Univ Kansas, Dept Aerosp Engn, Lawrence, KS 66045 USA. [Xu, Ying] Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China. [Wilson, D. K.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Zheng, ZC (reprint author), Univ Kansas, Dept Aerosp Engn, Lawrence, KS 66045 USA. EM zzheng@ku.edu RI Zheng, Z/E-8930-2011; Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineering Research and Development Center [W913E7-07-C-0004] FX This research was partly supported by the U.S. Army Engineering Research and Development Center under contract W913E7-07-C-0004 when the first two authors were at Kansas State University. NR 22 TC 6 Z9 6 U1 0 U2 9 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD APR PY 2011 VL 129 IS 4 BP 1740 EP 1747 DI 10.1121/1.3552886 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 747CT UT WOS:000289298600017 PM 21476631 ER PT J AU Ter-Gabrielyan, N Fromzel, V Lukasiewicz, T Ryba-Romanowski, W Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Lukasiewicz, T. Ryba-Romanowski, W. Dubinskii, M. TI Nearly quantum-defect-limited efficiency, resonantly pumped, Er3+:YVO4 laser at 1593.5nm SO OPTICS LETTERS LA English DT Article ID SOLID-STATE LASERS; 1.6 MU-M; YVO4 CRYSTALS; TEMPERATURE; RANGE; ER AB Nearly quantum-defect-limited laser operation of a resonantly pumped Er3+:YVO4 at 1593.5nm is demonstrated. Maximum slope efficiency of similar to 85% and true CW power of similar to 13W at 1593.5nm were achieved with a beam propagation factor of M-2 similar to 1.05. This slope efficiency is, to the best of our knowledge, the highest efficiency ever reported for a crystalline Er-doped laser. C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Lukasiewicz, T.] Inst Elect Mat Technol, Warsaw, Poland. [Ryba-Romanowski, W.] Polish Acad Sci, Inst Low Temp & Struct Res, Wroclaw, Poland. RP Dubinskii, M (reprint author), USA, Res Lab, Attn RDRL SEE O,2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 14 TC 17 Z9 17 U1 0 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD APR 1 PY 2011 VL 36 IS 7 BP 1218 EP 1220 PG 3 WC Optics SC Optics GA 746ML UT WOS:000289251000064 PM 21479035 ER PT J AU Wang, LJ Xu, ZY Sadler, BM AF Wang, Leijie Xu, Zhengyuan Sadler, Brian M. TI An approximate closed-form link loss model for non-line-of-sight ultraviolet communication in noncoplanar geometry SO OPTICS LETTERS LA English DT Article ID PERFORMANCE AB Non-line-of-sight UV communication link path loss models have been explored for both coplanar and noncoplanar geometries, and these typically require numerical evaluation. In this Letter, we propose a closed-form and easily applied model to describe link behavior, applicable to noncoplanar geometry. The model is compared with a recently reported analytical model and shows good agreement. (C) 2011 Optical Society of America C1 [Wang, Leijie; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu FU United States Army Research Office (USARO) [W911NF-09-1-0293] FX This work was supported by United States Army Research Office (USARO) grant W911NF-09-1-0293. NR 8 TC 19 Z9 21 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD APR 1 PY 2011 VL 36 IS 7 BP 1224 EP 1226 PG 3 WC Optics SC Optics GA 746ML UT WOS:000289251000066 PM 21479037 ER PT J AU Murray, CK Gray, MR Mende, K Parker, TM Samir, A Rahman, BA Habashy, EE Hospenthal, DR Pimentel, G AF Murray, Clinton K. Gray, Michael R. Mende, Katrin Parker, Tina M. Samir, Ahmed Rahman, Bassem Abdel Habashy, Engy E. Hospenthal, Duane R. Pimentel, Guillermo TI Use of patient-specific Leptospira isolates in the diagnosis of leptospirosis employing microscopic agglutination testing (MAT) SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Leptospirosis; diagnosis; microscopic agglutination testing; regional diagnosis ID ACUTE FEBRILE ILLNESS; PREDICTOR; SEROVAR; EGYPT AB Given the protean manifestations of leptospirosis, adequate laboratory support for diagnosis is necessary. Traditionally, the gold standard is the microscopic agglutination test (MAT) using a panel of Leptospira isolates representing a broad range of serogroups and serovars. It has been proposed that screening with serovars circulating in a region would enhance test performance. We assessed the diagnostic usefulness of MAT using both regionally obtained clinical Leptospira isolates and the specific isolates recovered from the tested patients. Serum obtained from 41 acute febrile patients (obtained on average 7.2 days [SD +/- 5.2] after onset of fever) was tested using a standard panel of 24 serovars along with regional isolates recovered from human and animal blood cultures from different regions in Egypt and a patient's own isolate, if available, to establish additional MAT panels. Serum samples tested by a standard 24 panel with a cut-off of >= 1:800 revealed five patients with positive serology. Only one patient had a positive result using a regional panel or patient's own culture developed MAT. However, the serovar with the highest titers did not match the cultured serovar. Region-specific MATs did not appear to be reliable in detection of infection or in identifying the infecting serovar. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 [Murray, Clinton K.; Mende, Katrin; Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Gray, Michael R.] US Army Vet Command, Ft Sam Houston, TX USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. [Parker, Tina M.; Samir, Ahmed; Rahman, Bassem Abdel; Habashy, Engy E.; Pimentel, Guillermo] NAMRU3, Cairo, Egypt. [Samir, Ahmed] Cairo Univ, Cairo, Egypt. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013; OI Pimentel, Guillermo/0000-0003-2464-1526 NR 10 TC 9 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD APR PY 2011 VL 105 IS 4 BP 209 EP 213 DI 10.1016/j.trstmh.2010.12.004 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 747QJ UT WOS:000289334200005 PM 21334705 ER PT J AU Vanfosson, CA AF Vanfosson, Christopher A. TI LETTERS FROM Afghanistan: Preparing to Return Home SO AMERICAN JOURNAL OF NURSING LA English DT Editorial Material C1 [Vanfosson, Christopher A.] USA, Nurse Corps, Salt Lake City, UT 84119 USA. [Vanfosson, Christopher A.] 541st Forward Surg Team Airborne, Pul E Khumri, Afghanistan. RP Vanfosson, CA (reprint author), USA, Nurse Corps, Salt Lake City, UT 84119 USA. EM christopher.vanfosson@mail.us.army.mil OI VanFosson, Christopher/0000-0003-1640-3018 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD APR PY 2011 VL 111 IS 4 BP 47 EP 49 DI 10.1097/01.NAJ.0000396555.79125.da PG 3 WC Nursing SC Nursing GA 742YX UT WOS:000288982400016 PM 21451296 ER PT J AU Siska, P Lauko, V AF Siska, Peter Lauko, Viliam TI Strategic missile deployment: A geographic perspective on central Europe SO APPLIED GEOGRAPHY LA English DT Article DE Strategic missile deployment; Geopolitics; Central Europe AB During the past several decades, central European region has undergone significant political, economical, and geopolitical changes. This period has been marked by sudden swings from the geopolitical and military exploits of Nazi Germany to Soviet dominated communism and then to a free market democracy after the downfall of the Iron Curtain. Following the Soviet Union, the main geopolitical force and military player in this region is the United States of America. The question now arises, which direction is the geopolitical pendulum going to swing in the coming decades? One crucial test of these current developments was the planned deployment of the ground based mid-course defense system (GMD) that was proposed by the United States and supported by the governments of Poland and the Czech Republic. The objective of this research is to determine the current geopolitical atmosphere in Poland. Slovakia and Czech Republic regarding the missile deployment and analyze additional factors that form public perception of current geopolitical status quo. As the results indicate, "the geopolitical pendulum" may swing again, but this time away from the United States towards more neutral ground. Published by Elsevier Ltd. C1 [Siska, Peter] US Mil Acad, Dept Geog & Environm Engn, Chair Reg Studies, West Point, NY 10996 USA. [Lauko, Viliam] Comenius Univ, Dept Reg Geog, Chair Reg Geog, Bratislava 84215, Slovakia. RP Siska, P (reprint author), US Mil Acad, Dept Geog & Environm Engn, Chair Reg Studies, West Point, NY 10996 USA. EM peter.siska@usma.edu; lauko@fns.uniba.sk NR 20 TC 0 Z9 0 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-6228 J9 APPL GEOGR JI Appl. Geogr. PD APR PY 2011 VL 31 IS 2 BP 829 EP 838 DI 10.1016/j.apgeog.2010.09.001 PG 10 WC Geography SC Geography GA 742UY UT WOS:000288971900043 ER PT J AU Griffith, J AF Griffith, James TI Reserve Forces-After the Cold War: An International Perspective SO ARMED FORCES & SOCIETY LA English DT Article DE reserve military service; international; mission changes ID MILITARY AB The topic of reserve military service began with the citizen-soldier who performs military duties periodically, fending off community threats. Now, the reservist routinely performs full-time military service in support of national security operations. Evident in this shift are matters of importance, such as the preparedness of the reserve force, staffing the reserve force in its new role, the demographic and social representativeness of the force, and so forth. Authors from different countries examine these and other issues concerning their reserve forces. Common content and themes in the articles are briefly described. C1 [Griffith, James] USA, Washington, DC USA. [Griffith, James] Amer Psychol Assoc, Div Mil Psychol, Div 19, Washington, DC USA. RP Griffith, J (reprint author), 10956 Bellehaven Blvd, Damascus, MD 20872 USA. EM James.E.Griffith@US.Army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2011 VL 37 IS 2 BP 209 EP 215 DI 10.1177/0095327X10396027 PG 7 WC Political Science; Sociology SC Government & Law; Sociology GA 736AM UT WOS:000288461900001 ER PT J AU Griffith, J AF Griffith, James TI Contradictory and Complementary Identities of US Army Reservists: A Historical Perspective SO ARMED FORCES & SOCIETY LA English DT Article DE reserve military service; social identity; citizen soldier; civilian-military gap ID SOCIAL IDENTITY; NATIONAL-GUARD; MILITARY; SOLDIERS; WAR; RETENTION; ATTITUDES; ORIENTATION; PERFORMANCE; MOTIVATION AB Over the past three decades, evolving threats to U.S. national security have necessitated changes in the missions, structure, and organization of reserve forces. These changes, while intended to redefine the purposes and functions of the U.S. reserve force, at times had unanticipated effects on the individual reservist's experience of and identity with reserve military service. Emergent identities include the obliged-conscripted citizen soldier, weekend warrior, instrumental volunteer, identity seeker, soldier warrior, and conservative ideologue. The author elaborates on these identities and their association with geopolitical events and corresponding responses in the U.S. national defense strategy and concludes by discussing the implications of more recent identities for adequately staffing and readying the U.S. reserve force. C1 [Griffith, James] US Army Natl Guard, Baltimore, MD USA. RP Griffith, J (reprint author), 10956 Bellehaven Blvd, Damascus, MD 20872 USA. EM James.E.Griffith@US.Army.mil NR 78 TC 4 Z9 4 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2011 VL 37 IS 2 BP 261 EP 283 DI 10.1177/0095327X09354167 PG 23 WC Political Science; Sociology SC Government & Law; Sociology GA 736AM UT WOS:000288461900004 ER PT J AU Fernandez, S Cisney, ED Tikhonov, AP Schweitzer, B Putnak, RJ Simmons, M Ulrich, RG AF Fernandez, Stefan Cisney, Emily D. Tikhonov, Alexander P. Schweitzer, Barry Putnak, Robert J. Simmons, Monika Ulrich, Robert G. TI Antibody Recognition of the Dengue Virus Proteome and Implications for Development of Vaccines SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; NONSTRUCTURAL PROTEINS; ENVELOPE PROTEIN; DISEASE SEVERITY; MICE; NS1; GLYCOPROTEIN; IMMUNIZATION; INFECTION AB Dengue is a mosquito-borne infection caused by four distinct serotypes of dengue virus, each appearing cyclically in the tropics and subtropics along the equator. Although vaccines are currently under development, none are available to the general population. One of the main impediments to the successful advancement of these vaccines is the lack of well-defined immune correlates of protection. Here, we describe a protein microarray approach for measuring antibody responses to the complete viral proteome comprised of the structural (capsid, membrane, and envelope) and nonstructural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) components of all four dengue virus serotypes (1 to 4). We examined rhesus macaques vaccinated with tetravalent vaccines consisting of live-attenuated virus (LAV) or purified inactivated virus (PIV), followed by boosting with LAV and challenging with wild-type dengue virus. We detected temporal increases in antibodies against envelope proteins in response to either vaccine, while only the PIV/LAV vaccination strategy resulted in anticapsid antibodies. In contrast to results from vaccination, naive macaques challenged with wild-type viruses of each serotype demonstrated a balanced response to nonstructural and structural components, including responses against the membrane protein. Our results demonstrate discriminating details concerning the nature of antibody responses to dengue virus at the proteomic level and suggest the usefulness of this information for vaccine development. C1 [Fernandez, Stefan; Cisney, Emily D.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Tikhonov, Alexander P.; Schweitzer, Barry] Life Technol, Carlsbad, CA USA. [Putnak, Robert J.; Simmons, Monika] WRAIR NMRC, Silver Spring, MD 20910 USA. RP Fernandez, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM stefan.fernandez@us.army.mil; robert.g.ulrich@us.army.mil RI Tikhonov, Alexander/I-1453-2012 OI Tikhonov, Alexander/0000-0003-3808-9701 FU Joint Science and Technology Office [W81XWH-05-2-0077] FX This work was supported by the Joint Science and Technology Office W81XWH-05-2-0077 (B. S., R. G. U.). NR 44 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2011 VL 18 IS 4 BP 523 EP 532 DI 10.1128/CVI.00016-11 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 746IL UT WOS:000289238500001 PM 21270280 ER PT J AU Fernandez, S Cisney, ED Hall, SI Ulrich, RG AF Fernandez, Stefan Cisney, Emily D. Hall, Shannan I. Ulrich, Robert G. TI Nasal Immunity to Staphylococcal Toxic Shock Is Controlled by the Nasopharynx-Associated Lymphoid Tissue SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID NONTYPABLE HAEMOPHILUS-INFLUENZAE; OUTER-MEMBRANE PROTEIN; MUCOSAL IMMUNITY; INTRANASAL IMMUNIZATION; ESCHERICHIA-COLI; ENTEROTOXIN-B; SYSTEMIC IMMUNITY; CONJUGATE VACCINE; DENDRITIC CELLS; CUTTING EDGE AB The nasopharynx-associated lymphoid tissue (NALT) of humans and other mammals is associated with immunity against airborne infections, though it is generally considered to be a secondary component of the mucosa-associated lymphoid system. We found that protective immunity to a virulence factor of nasal mucosa-colonizing Staphylococcus aureus, staphylococcal enterotoxin B (SEB), requires a functional NALT. We examined the role of NALT using intranasal (IN) vaccination with a recombinant SEB vaccine (rSEBv) combined with an adjuvant in a mouse model of SEB-induced toxic shock. The rSEBv was rapidly internalized by NALT cells at the mucosal barrier, and transport into NALT was accelerated by inclusion of a Toll-like receptor 4 (TLR4) agonist. Vaccine-induced germinal centers of B cells formed within NALT, accompanied by elevated levels of IgA(+) and IgG(+) cells, and these were further increased by TLR4 activation. The NALT was the site of specific anti-rSEBv IgA and IgG production but was also influenced by intraperitoneal (IP) inoculation and perhaps other isolated lymphoid follicles observed within the nasal cavity. Vaccination by the IN route generated robust levels of anti-rSEBv IgA in saliva, nasal secretions, and blood compared to much lower levels after IP vaccination. IN vaccination also induced secretion of anti-rSEBv IgG in the blood and nasal secretions. Significantly, the efficacy of IN vaccination was dependent on NALT, as surgical removal resulted in greater sensitivity to IN challenge with wild-type SEB. Thus, protective immunity to SEB within the nasal sinuses was elicited by responses originating in NALT. C1 [Fernandez, Stefan; Cisney, Emily D.; Hall, Shannan I.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Fernandez, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM stefan.fernandez@us.army.mil; rulrich@bioanalysis.org FU Becton Dickinson Technologies [17-03-2-0037] FX Support was provided by Becton Dickinson Technologies (DAMD award number 17-03-2-0037). We have no financial conflict of interest. Views expressed in this paper are ours and do not purport to reflect the official policy of the U.S. Government. NR 51 TC 9 Z9 10 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2011 VL 18 IS 4 BP 667 EP 675 DI 10.1128/CVI.00477-10 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 746IL UT WOS:000289238500022 PM 21325486 ER PT J AU Fregoso, MM Brenner, R Collen, J Reffett, T Brown, AW Shlobin, OA Ahmad, S Lemma, M Nathan, SD AF Fregoso, M. M. Brenner, R. Collen, J. Reffett, T. Brown, A. W. Shlobin, O. A. Ahmad, S. Lemma, M. Nathan, S. D. TI BOS, "DeBos" and "ReBos": When Is a Drop in the FEV1 Really Permanent? SO JOURNAL OF HEART AND LUNG TRANSPLANTATION LA English DT Meeting Abstract CT 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation CY APR 13-16, 2011 CL San Diego, CA SP Int Soc Heart & Lung Transplantat C1 [Fregoso, M. M.; Brenner, R.; Reffett, T.; Brown, A. W.; Shlobin, O. A.; Ahmad, S.; Lemma, M.; Nathan, S. D.] Inova Fairfax Hosp, Adv Lung Dis & Transplant Program, Falls Church, VA USA. [Collen, J.] Walter Reed Army Med Ctr, Div Pulm & Crit Care, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1053-2498 J9 J HEART LUNG TRANSPL JI J. Heart Lung Transplant. PD APR PY 2011 VL 30 IS 4 SU S MA 139 BP S53 EP S53 PG 1 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery; Transplantation SC Cardiovascular System & Cardiology; Respiratory System; Surgery; Transplantation GA 742EO UT WOS:000288924300140 ER PT J AU Marion, DW Curley, KC Schwab, K Hicks, RR AF Marion, Donald W. Curley, Kenneth C. Schwab, Karen Hicks, Ramona R. CA mTBI Diagnostics Workgrp TI Proceedings of the Military mTBI Diagnostics Workshop, St. Pete Beach, August 2010 SO JOURNAL OF NEUROTRAUMA LA English DT Article DE concussion; diagnosis; mild traumatic brain injury; Neurocognitive Assessment Tool (NCAT); Military Acute Concussion Evaluation (MACE); Operation Iraqi Freedom (OIF); Operation Enduring Freedom (OEF); military mild traumatic brain injury ID TRAUMATIC BRAIN-INJURY; COLLEGIATE FOOTBALL PLAYERS; BIOCHEMICAL MARKERS; HEAD-INJURY; CONCUSSION; SERUM; S-100B; DAMAGE; S100B; BIOMARKERS AB Approximately 28,000 service members (SMs) sustain a traumatic brain injury (TBI) each year in the U. S. military. The majority of the injuries result either in a brief or no loss of consciousness, and are classified as a mild TBI (mTBI or concussion). Current evaluation guidelines of SMs suspected of having a mTBI rely heavily on self-reports. However, there is concern that SMs typically minimize or do not report their symptoms of mTBI for fear that doing so will result in being removed from the battlefield. Because mTBI often results in headaches, cognitive dysfunction, attention difficulties, and balance problems, returning to the battlefield before resolution of their symptoms can be dangerous for the SM and for their unit. Sustaining a second concussion before resolution of a previous mTBI also may make long-term neuronal injury more likely. The mTBI Diagnostics Workshop was designed as a forum where civilian and military experts from a variety of TBI-related clinical and basic science disciplines could meet to define the diagnostic tools, alone or in combination, that were most likely to result in an acute, objective diagnosis of mTBI. The premise of the meeting was that a small number of well-focused research projects conducted over the next 2-3 years could be done to validate the optimal test, or more likely combination of tests, that would be practical and reliable for the acute diagnosis of mTBI within 2-3 h of injury in theater. The recommendations of the Workshop are provided in this report. C1 [Marion, Donald W.; Schwab, Karen] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Curley, Kenneth C.] USA, Combat Casualty Care Directorate, Med Res & Mat Command, Ft Detrick, MD USA. [Hicks, Ramona R.] NINDS, Bethesda, MD 20892 USA. RP Marion, DW (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B209 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Donald.Marion@us.army.mil FU mTBI Diagnostics Workshop FX Support for the mTBI Diagnostics Workshop was provided by Col. Dallas Hack, Director of the Combat Casualty Care Directorate, U.S. Army Medical Research and Materiel Command, and by Col. Jamie Grimes, National Director of the Defense and Veterans Brain Injury Center. Marithea Goberville, Ph.D., provided a transcript of the report-out session of the conference. NR 36 TC 19 Z9 21 U1 0 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD APR PY 2011 VL 28 IS 4 BP 517 EP 526 DI 10.1089/neu.2010.1638 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 746IW UT WOS:000289240200003 PM 21265587 ER PT J AU Drost, RJ Moore, TJ Sadler, BM AF Drost, Robert J. Moore, Terrence J. Sadler, Brian M. TI UV communications channel modeling incorporating multiple scattering interactions SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID LIGHT-EMITTING-DIODES; PERFORMANCE; LINKS AB In large part because of advancements in the design and fabrication of UV LEDs, photodetectors, and filters, significant research interest has recently been focused on non-line-of-sight UV communication systems. This research in, for example, system design and performance prediction, can be greatly aided by accurate channel models that allow for the reproducibility of results, thus facilitating the fair and consistent comparison of different communication approaches. In this paper, we provide a comprehensive derivation of a multiple-scattering Monte Carlo UV channel model, addressing weaknesses in previous treatments. The resulting model can be used to study the contribution of different orders of scattering to the path loss and impulse response functions associated with general UV communication system geometries. Simulation results are provided that demonstrate the benefit of this approach. (c) 2011 Optical Society of America C1 [Drost, Robert J.; Moore, Terrence J.; Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.drost@us.army.mil FU Oak Ridge Associated Universities through USARL FX This research was supported in part by an appointment to the United States Army Research Laboratory (USARL) Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the USARL. NR 27 TC 31 Z9 34 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD APR PY 2011 VL 28 IS 4 BP 686 EP 695 PG 10 WC Optics SC Optics GA 745VT UT WOS:000289199100027 PM 21478967 ER PT J AU Siaki, LA AF Siaki, Leilani A. TI Translating Questions for Use With Samoan Adults: Lessons Learned SO JOURNAL OF TRANSCULTURAL NURSING LA English DT Article DE diabetes; transcultural health; Samoan; translators; interpreters ID CROSS-CULTURAL RESEARCH; HEALTH; ISLANDERS; ISSUES AB The purpose of this article was to present the process of translating questions about perceived risk for diabetes into Samoan and describe important cultural adaptations to the modified Brislin's translation model for cross-cultural research. With the assistance of a culture broker and several Samoan translators, 14 questions were translated into the Samoan language. Cultural adaptations included using a group approach, working with a matai, and following protocols such as fa'alavelave. Questions were back-translated and then pilot tested. Results from the pilot testing supported the use of these cultural modifications in the translation model. C1 [Siaki, Leilani A.] Univ Arizona, Tucson, AZ USA. RP Siaki, LA (reprint author), Tripler Army Med Ctr, 92-917,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM leilani.a.siaki@us.army.mil NR 34 TC 3 Z9 3 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1043-6596 J9 J TRANSCULT NURS JI J. Transcult. Nurs. PD APR PY 2011 VL 22 IS 2 BP 122 EP 128 DI 10.1177/1043659610395766 PG 7 WC Nursing SC Nursing GA 745NB UT WOS:000289171000003 PM 21311087 ER PT J AU Siaki, LA Loescher, LJ AF Siaki, Leilani A. Loescher, Lois J. TI Pacific Islanders' Perceived Risk of Cardiovascular Disease and Diabetes SO JOURNAL OF TRANSCULTURAL NURSING LA English DT Article DE perceived risk; risk perceptions; Pacific Islanders; cardiovascular disease; diabetes ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CHILDHOOD IMMUNIZATIONS; WOMEN; PERCEPTION; HEALTH; AMERICAN; MEN; VULNERABILITY; POPULATION AB Purpose: To explore literature on Pacific Islanders' perceived risk of cardiovascular disease (CVD) and diabetes. Method: A search of literature databases for English-language perceived risk research published from 2000 to 2008. Results: Few studies targeting perceived risk of CVD (n = 6) and diabetes (n = 4) included minority participants. No studies targeted Pacific Islanders exclusively. Overall, Pacific Islanders and other minority groups inaccurately perceive their risk of these conditions. No studies explored cultural relevancy or measurement of perceived risk. Implications: Perceived risk, an integral part of health behavior change theories, is greatly understudied in Pacific Islanders. Perceived risk research for CVD and diabetes is sparse for any minority group. More research is needed to develop socioculturally appropriate interventions that promote accurate risk perceptions for both diseases and facilitate adoption of health behaviors. Ultimately, these behaviors will reduce the onset and devastating consequences of CVD and diabetes in Pacific Islanders and other minority populations. C1 [Siaki, Leilani A.; Loescher, Lois J.] Univ Arizona, Tucson, AZ USA. RP Siaki, LA (reprint author), USA, Nurse Corps, 92-917,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM leilani.a.siaki@us.army.mil FU NIH-NCI [K07CA106996] FX Dr. Loescher's work on this article was supported by Grant NIH-NCI K07CA106996. NR 60 TC 2 Z9 2 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1043-6596 J9 J TRANSCULT NURS JI J. Transcult. Nurs. PD APR PY 2011 VL 22 IS 2 BP 191 EP 200 DI 10.1177/1043659610395763 PG 10 WC Nursing SC Nursing GA 745NB UT WOS:000289171000012 PM 21467270 ER PT J AU Borgman, MA Maegele, M Wade, CE Blackbourne, LH Spinella, PC AF Borgman, Matthew A. Maegele, Marc Wade, Charles E. Blackbourne, Lorne H. Spinella, Philip C. TI Pediatric Trauma BIG Score: Predicting Mortality in Children After Military and Civilian Trauma SO PEDIATRICS LA English DT Article DE wounds and injuries; pediatrics; shock; outcome assessment; prognosis ID PARTIAL THROMBOPLASTIN TIME; CHILDHOOD INJURY SEVERITY; HYPERCOAGULABLE STATE; OBJECTIVE MEASUREMENT; PROTHROMBIN TIME; RISK INDICATOR; BASE DEFICIT; COAGULOPATHY; AGE; THROMBOELASTOGRAPHY AB OBJECTIVE: To develop a validated mortality prediction score for children with traumatic injuries. PATIENTS AND METHODS: We identified all children (<18 years of age) in the US military established Joint Theater Trauma Registry from 2002 to 2009 who were admitted to combat-support hospitals with traumatic injuries in Iraq and Afghanistan. We identified factors associated with mortality using univariate and then multivariate regression modeling. The developed mortality prediction score was then validated on a data set of pediatric patients (<= 18 years of age) from the German Trauma Registry, 2002-2007. RESULTS: Admission base deficit, international normalized ratio, and Glasgow Coma Scale were independently associated with mortality in 707 patients from the derivation set and 1101 patients in the validation set. These variables were combined into the pediatric "BIG" score (base deficit + [2.5 x international normalized ratio] + [15 - Glasgow Coma Scale), which were each calculated to have an area under the curve of 0.89 (95% confidence interval: 0.83-0.95) and 0.89 (95% confidence interval: 0.87-0.92) on the derivation and validation sets, respectively. CONCLUSIONS: The pediatric trauma BIG score is a simple method that can be performed rapidly on admission to evaluate severity of illness and predict mortality in children with traumatic injuries. The score has been shown to be accurate in both penetrating-injury and blunt-injury populations and may have significant utility in comparing severity of injury in future pediatric trauma research and quality-assurance studies. In addition, this score may be used to determine inclusion criteria on admission for prospective studies when accurately estimating the mortality for sample size calculation is required. Pediatrics 2011; 127: e892-e897 C1 [Borgman, Matthew A.] Childrens Hosp Boston, Boston, MA USA. [Borgman, Matthew A.] Brooke Army Med Ctr, San Antonio, TX USA. [Maegele, Marc] Cologne Merheim Med Ctr, Cologne, Germany. [Maegele, Marc] Registry Deutsch Gesell Unfallchirurg, Cologne, Germany. [Wade, Charles E.] UniTexas Hlth Sci Ctr, Houston, TX USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Spinella, Philip C.] Blood Res Syst Inst, San Francisco, CA USA. RP Borgman, MA (reprint author), Brooke Army Med Ctr, MCHE DP PICU, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM matthew.borgman@us.army.mil RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 31 TC 30 Z9 30 U1 1 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2011 VL 127 IS 4 BP E892 EP E897 DI 10.1542/peds.2010-2439 PG 6 WC Pediatrics SC Pediatrics GA 744DQ UT WOS:000289074800005 PM 21422095 ER PT J AU Hagerty, BM Williams, RA Bingham, M Richard, M AF Hagerty, Bonnie M. Williams, Reg Arthur Bingham, Mona Richard, Maggie TI Military Nurses and Combat-Wounded Patients: A Qualitative Analysis of Psychosocial Care SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Casualties; combat; military nurses; psychosocial ID MENTAL-HEALTH PROBLEMS; AFGHANISTAN; DEPLOYMENT; SERVICES; SOLDIERS; EVENTS; IRAQ; WAR AB PURPOSE: The aims were to explore the lived experience of combat-wounded patients and the military nurses who care for them. DESIGN AND METHODS: The study was a qualitative phenomenological design, and focus groups were conducted with 20 nurses and 8 combat-wounded patients. FINDINGS: Themes common to nurses and patients were coping, shared experiences, finding meaning, psychosocial nursing care, families, and bureaucratic structure. Thematic differences were the patients' perspectives "changed self" while nurses described "professional boundaries." PRACTICE IMPLICATIONS: The importance of finding meaning presents ideas that could help nurses and patients cope better with stressful situations regardless of the setting. C1 [Williams, Reg Arthur] Univ Michigan, Sch Med, Sch Nursing & Psychiat, Ann Arbor, MI 48109 USA. [Hagerty, Bonnie M.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Bingham, Mona] Brooke Army Med Ctr, San Antonio, TX USA. [Richard, Maggie] Bur Med & Surg, Navy Human Res Protect Program, Washington, DC USA. RP Williams, RA (reprint author), Univ Michigan, Sch Med, Sch Nursing & Psychiat, Ann Arbor, MI 48109 USA. EM rawill@umich.edu FU Uniformed Services University of the Health Sciences, Department of Defense [TSNRP N06-P16, MDA-HU0001-06-1-TS11]; National Naval Medical Center, Bethesda, MD; Brooke Army Medical Center; Wilford Hall Air Force Medical Center, San Antonio, TX; School of Nursing, University of Michigan FX The Department of Defense, TriService Nursing Research Program sponsored this research (TSNRP N06-P16, MDA-HU0001-06-1-TS11) at the Uniformed Services University of the Health Sciences. The information or content and conclusions, however, do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, the Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Government.; The authors wish to extend appreciation to National Naval Medical Center, Bethesda, MD; Brooke Army Medical Center; Wilford Hall Air Force Medical Center, San Antonio, TX; the School of Nursing, University of Michigan; and Gary Gatien, Project Manager for their support of this research project. NR 24 TC 6 Z9 6 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD APR PY 2011 VL 47 IS 2 BP 84 EP 92 DI 10.1111/j.1744-6163.2010.00275.x PG 9 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 739ZF UT WOS:000288760100004 PM 21426353 ER PT J AU House, JM AF House, Jonathan M. TI Dealing with the Devil: Anglo-Soviet Intelligence Cooperation During the Second World War SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD APR PY 2011 VL 70 IS 2 BP 351 EP 352 PG 2 WC History SC History GA 736TB UT WOS:000288515900037 ER PT J AU Wright, D AF Wright, Don TI Armageddon in Stalingrad: September-November 1942 SO RUSSIAN REVIEW LA English DT Book Review C1 [Wright, Don] USA, Combat Studies Inst, Washington, DC 20310 USA. RP Wright, D (reprint author), USA, Combat Studies Inst, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD APR PY 2011 VL 70 IS 2 BP 352 EP 353 PG 2 WC History SC History GA 736TB UT WOS:000288515900038 ER PT J AU Tan, KR Magill, AJ Parise, ME Arguin, PM AF Tan, Kathrine R. Magill, Alan J. Parise, Monica E. Arguin, Paul M. TI Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MOUNTAIN-SPOTTED-FEVER; PLASMODIUM-FALCIPARUM MALARIA; INDUCED AUTOIMMUNE HEPATITIS; PLACEBO-CONTROLLED TRIAL; UNITED-STATES TROOPS; DOUBLE-BLIND; IN-VITRO; TETRACYCLINE THERAPY; ANTIMALARIAL-DRUGS; CHLOROQUINE-RESISTANT AB Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children <8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxvcycline for malaria and summarizes the available literature on its safety and tolerability. C1 [Tan, Kathrine R.; Arguin, Paul M.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30341 USA. [Magill, Alan J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Parise, Monica E.] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30341 USA. RP Tan, KR (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, 4770 Buford Hwy MS F-22, Atlanta, GA 30341 USA. EM ktan@cdc.gov; alan.magill@us.army.mil; mparise@cdc.gov; parguin@cdc.gov NR 158 TC 44 Z9 44 U1 3 U2 15 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2011 VL 84 IS 4 BP 517 EP 531 DI 10.4269/ajtmh.2011.10-0285 PG 15 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 743MY UT WOS:000289023600003 PM 21460003 ER PT J AU Glasser, JS Murray, CK AF Glasser, Jessie S. Murray, Clinton K. TI Case Report: Central Nervous System Toxicity Associated with Liposomal Amphotericin B Therapy for Cutaneous Leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TISSUE DISTRIBUTION; EFFICACY; AMBISOME; BRAZILIENSIS; MENINGITIS; SAFETY AB AmBisome (liposomal amphotericin B) is used for prophylaxis and treatment of fungal infections, treatment of visceral leishmaniasis, and more recently, treatment of cutaneous leishmaniasis. Although the package insert cites neurologic toxicities in up to 20% of cases, review of the literature did not reveal any specific cases describing this side effect, particularly in a patient without comorbidities. We describe a healthy 38-year-old male treated with liposomal amphotericin B for cutaneous leishmaniasis acquired during military duties in Iraq. Shortly after completion of his treatment course, he reported memory difficulties and confusion. Further evaluation revealed no other source, and his cognitive issues were attributed to liposomal amphotericin B toxicity. These issues resolved over a few weeks, which is consistent with data about the drug's tissue penetration and metabolism available in the literature. This is a potential side effect of liposomal amphotericin B that can be observed in otherwise healthy patients. C1 [Glasser, Jessie S.; Murray, Clinton K.] Brooke Army Med Ctr, US Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Glasser, JS (reprint author), Brooke Army Med Ctr, US Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jessie.glasser@amedd.army.mil; Clinton.Murray@amedd.army.mil NR 19 TC 5 Z9 5 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2011 VL 84 IS 4 BP 566 EP 568 DI 10.4269/ajtmh.2011.10-0662 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 743MY UT WOS:000289023600011 PM 21460011 ER PT J AU Rodkvamtook, W Ruang-Areerate, T Gaywee, J Richards, AL Jeamwattanalert, P Bodhidatta, D Sangjun, N Prasartvit, A Jatisatienr, A Jatisatienr, C AF Rodkvamtook, Wuttikon Ruang-areerate, Toon Gaywee, Jariyanart Richards, Allen L. Jeamwattanalert, Pimmada Bodhidatta, Dharadhida Sangjun, Noppadon Prasartvit, Anchana Jatisatienr, Araya Jatisatienr, Chaiwat TI Isolation and Characterization of Orientia tsutsugamushi from Rodents Captured following a Scrub Typhus Outbreak at a Military Training Base, Bothong District, Chonburi Province, Central Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYACRYLAMIDE-GEL ELECTROPHORESIS; RICKETTSIA-TSUTSUGAMUSHI; PHYLOGENETIC ANALYSIS; SEQUENCE HOMOLOGIES; ANTIGEN GENES; CLASSIFICATION; STRAINS; IMMUNOFLUORESCENCE; IDENTIFICATION; AUSTRALIA AB Orientia tsutsugamushi, an obligate intracellular Gram-negative bacterium, is the causative agent of scrub typhus, a vector-borne disease transmitted by infected chiggers (trombiculid mite larvae). In 2002, an outbreak of scrub typhus occurred among Royal Thai Army troops during the annual field training at a military base in Bothong district, Chonburi province, central Thailand. This report describes the outbreak investigation including its transmission cycle. Results showed that 33.9% of 174 trained troops had scrub typhus-like signs and symptoms and 9.8% of those were positive for O. tsutsugamushi-specific antibodies by indirect fluorescence antibody assay. One hundred thirty-five rodents were captured from this training area,43% of them had antibodies against O. tsutsugamushi. Six new O. tsutsugamushi isolates were obtained from captured rodent tissues and successfully established in cell culture. Phylogenetic studies showed that these six isolates were either unique or related to a native genotype of previously described isolates from Thailand. C1 [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Jatisatienr, Araya; Jatisatienr, Chaiwat] Chiang Mai Univ, Dept Biol, Fac Sci, Chiang Mai 50000, Thailand. [Rodkvamtook, Wuttikon; Ruang-areerate, Toon; Gaywee, Jariyanart] Royal Thai Army, Armed Forces Res Inst Med Sci, Dept Epidemiol, Div Res, Bangkok, Thailand. Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA. [Prasartvit, Anchana] Minist Publ Hlth, Bur Gen Communicable Dis, Dept Dis Control, Nonthaburi, Thailand. [Jeamwattanalert, Pimmada] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Sangjun, Noppadon] Royal Thai Army, Armed Forces Res Inst Med Sci, Dept Lab Anim, Div Anal, Bangkok, Thailand. RP Richards, AL (reprint author), USN, Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM wuttikornr@afrims.go.th; youangtr@yahoo.com; jariyanartg@afrims.org; Allen.Richards@med.navy.mil; pimmadaj@afrims.org; dbodhi@hotmail.com; noppadon625@yahoo.com; A_Pasartvit@yahoo.com; Arayarj@yahoo.com; Jchaiwat@chiangmai.ac.th RI Valle, Ruben/A-7512-2013 FU Thanphuying Viraya Chavakul Foundation for Medical Armed Forces Research; Department of Biology,Faculty of Science and the Graduate school, Chiang Mai University Thailand; Armed Forces Research Institute of Medical Science (AFRIMS) Royal Thai Army, Bangkok Thailand; GEIS/AFHSC [847705.82000.25GB. A0074] FX This work was supported by Thanphuying Viraya Chavakul Foundation for Medical Armed Forces Research Grant (2008), the Department of Biology,Faculty of Science and the Graduate school, Chiang Mai University Thailand, the Armed Forces Research Institute of Medical Science (AFRIMS) Royal Thai Army, Bangkok Thailand, and GEIS/AFHSC work unit number 847705.82000.25GB. A0074 for the financial support of this project. NR 42 TC 9 Z9 9 U1 1 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2011 VL 84 IS 4 BP 599 EP 607 DI 10.4269/ajtmh.2011.09-0768 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 743MY UT WOS:000289023600017 PM 21460017 ER PT J AU Patel, VM Nasrabadi, NM Chellappa, R AF Patel, Vishal M. Nasrabadi, Nasser M. Chellappa, Rama TI Sparsity-motivated automatic target recognition SO APPLIED OPTICS LA English DT Article ID SIGNAL RECOVERY; BASIS PURSUIT; ATOMIC DECOMPOSITION; MATCHING PURSUIT; REGRESSION; SELECTION; LASSO AB We present an automatic target recognition algorithm using the recently developed theory of sparse representations and compressive sensing. We show how sparsity can be helpful for efficient utilization of data for target recognition. We verify the efficacy of the proposed algorithm in terms of the recognition rate and confusion matrices on the well known Comanche (Boeing-Sikorsky, USA) forward-looking IR data set consisting of ten different military targets at different orientations. (C) 2011 Optical Society of America C1 [Patel, Vishal M.; Chellappa, Rama] Univ Maryland, Dept Elect & Comp Engn, Ctr Automat Res, College Pk, MD 20742 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Patel, VM (reprint author), Univ Maryland, Dept Elect & Comp Engn, Ctr Automat Res, College Pk, MD 20742 USA. EM pvishalm@umiacs.umd.edu NR 29 TC 19 Z9 22 U1 1 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD APR 1 PY 2011 VL 50 IS 10 BP 1425 EP 1433 DI 10.1364/AO.50.001425 PG 9 WC Optics SC Optics GA 744CF UT WOS:000289070300021 PM 21460910 ER PT J AU Kholod, YA Gryn'ova, G Gorb, L Hill, FC Leszczynski, J AF Kholod, Yana A. Gryn'ova, Ganna Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI Evaluation of the dependence of aqueous solubility of nitro compounds on temperature and salinity: A COSMO-RS simulation SO CHEMOSPHERE LA English DT Article DE Aqueous solubility; Seawater; Nitro compounds; COSMO-RS ID PURE WATER; MICROBIAL-DEGRADATION; MARINE SEDIMENT; SCREENING MODEL; REAL SOLVENTS; EXPLOSIVES; PREDICTION; SEAWATER; 2,6-DINITROTOLUENE; PHOTODEGRADATION AB The solubility in pure and saline water at various temperatures was calculated for selected nitro compounds (nitrobenzene, 1,3,5-trinitrobenzene, 2-nitrotoluene, 3-nitrotoluene, 4-nitrotoluene, 2,4-dinitrotoluene, 2,6-dinitrotoluene, 2,3-dinitrotoluene, 3,4-dinitrotoluene, 2,4,6-trinitrotoluene) using the Conductor-like Screening model for Real Solvents (COSMO-RS). The results obtained were compared with experimental values. The COSMO-RS predictions have shown high accuracy in reproducing the trends of aqueous solubilities for both temperature and salinity. The proposed methodology was then applied to predict the aqueous solubilities of 19 nitro compounds in the temperature range of 5-50 degrees C in saline solutions. The salting-out parameters of the Setschenow equation were also calculated. The predicted salting-out parameters were overestimated when compared to the measured values, but these parameters can still be used for qualitative estimation of the trends. (c) 2010 Elsevier Ltd. All rights reserved. C1 [Kholod, Yana A.; Gryn'ova, Ganna; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Gorb, Leonid] SpecPro Inc, Huntsville, AL 35805 USA. [Hill, Frances C.; Leszczynski, Jerzy] USA Army ERDC, Vicksburg, MS 39180 USA. RP Kholod, YA (reprint author), Iowa State Univ, Ames Lab US DOE, 201 Spedding Hall, Ames, IA 50011 USA. EM yana@iastate.edu RI Gryn'ova, Ganna/F-5931-2012 OI Gryn'ova, Ganna/0000-0003-4229-939X FU United States Army Corps of Engineers by the USAERDC FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the US Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. The authors thank Professor Rebecca Toghiani of the Mississippi State University for enlightening discussions. NR 37 TC 11 Z9 11 U1 0 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2011 VL 83 IS 3 BP 287 EP 294 DI 10.1016/j.chemosphere.2010.12.065 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 745RT UT WOS:000289184100010 PM 21215986 ER PT J AU Hjelkrem, M Stengel, J Liu, M Jones, DP Harrison, SA AF Hjelkrem, Michael Stengel, Joel Liu, Mark Jones, David P. Harrison, Stephen A. TI MiraLAX Is Not as Effective as GoLytely in Bowel Cleansing Before Screening Colonoscopies SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE Colon Cancer Screening; Colon Preparation; Colorectal Neoplasia; Cathartics ID COLORECTAL-CANCER; PREPARATION QUALITY; PEG SOLUTION; TRIAL; ELECTROLYTES; IMPACT; VOLUME; BLIND AB BACKGROUND & AIMS: Successful colonoscopies require good bowel preparations-poor bowel preparations can increase medical costs, rates of missed lesions, and procedure duration. The combination of polyethylene glycol (PEG) 3350 without electrolytes (MiraLAX; Schering-Plough Healthcare Products, Inc, Kenilworth, NJ) and 64 oz of Gatorade (PepsiCo, Inc, Purchase, NY) has gained popularity as a bowel preparation regimen. However, the efficacy and tolerability of this approach has not been compared with standard bowel preparations in clinical trials. We compared split-dose (PEG) 3350 with electrolytes (GoLytely; Braintree Laboratories, Inc, Braintree, MA) with split-dose MiraLAX alone and in combination with pretreatment medications (bisacodyl or lubiprostone) to determine the efficacy and patient tolerability of MiraLAX as an agent for bowel preparation. METHODS: We performed a prospective, randomized, blinded, controlled trial at a tertiary care center. Patients (n = 403) were randomly assigned to groups given GoLytely, MiraLAX, MiraLAX with bisacodyl (10 mg), or MiraLAX with lubiprostone (24 mu g). MiraLAX was combined with 64 oz of Gatorade. All patients were surveyed regarding preparation satisfaction and tolerability. The Ottawa bowel preparation scale was used to grade colon cleanliness. RESULTS: GoLytely was more effective at bowel cleansing (average Ottawa score, 5.1) than MiraLAX alone (average Ottawa score, 6.9) or in combination with lubiprostone (average Ottawa score, 6.8), or bisacodyl (average Ottawa score, 6.3) (P < .001). MiraLAX was associated with a trend toward longer procedure duration (P = .096). Groups given MiraLAX rated the overall experience as more satisfactory than those given GoLytely (P < .001). There were no differences between polyp detection rates (P = .346) or adverse events (P = .823). CONCLUSIONS: Split-dose MiraLAX in 64 oz of Gatorade is not as effective as 4 L split-dose GoLytely in bowel cleansing for screening colonoscopies. C1 [Hjelkrem, Michael] Brooke Army Med Ctr, Gastroenterol Clin, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Hjelkrem, M (reprint author), Brooke Army Med Ctr, Gastroenterol Clin, Dept Med, Div Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mhjelkrem@yahoo.com NR 21 TC 29 Z9 29 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD APR PY 2011 VL 9 IS 4 BP 326 EP U74 DI 10.1016/j.cgh.2010.11.007 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 745ED UT WOS:000289147400017 PM 21115134 ER PT J AU Awan, SN Helou, LB Stojadinovic, A Solomon, NP AF Awan, Shaheen N. Helou, Leah B. Stojadinovic, Alexander Solomon, Nancy Pearl TI Tracking voice change after thyroidectomy: application of spectral/cepstral analyses SO CLINICAL LINGUISTICS & PHONETICS LA English DT Article DE Thyroidectomy; cepstral analysis; cepstrum; spectral analysis; voice outcomes ID DYSPHONIA SEVERITY INDEX; CONTINUOUS SPEECH; PERCEPTUAL EVALUATION; CONNECTED SPEECH; LARYNGEAL NERVE; ACOUSTIC INDEX; OUTCOMES; QUALITY; SURGERY; MODEL AB This study evaluates the utility of perioperative spectral and cepstral acoustic analyses to monitor voice change after thyroidectomy. Perceptual and acoustic analyses were conducted on speech samples (sustained vowel //E// and CAPE-V sentences) provided by 70 participants (36 women and 34 men) at four study time points: prior to thyroid surgery and 2 weeks, 3 months and 6 months after thyroidectomy. Repeated measures analyses of variance focused on the relative amplitude of the dominant harmonic in the voice signal (cepstral peak prominence, CPP), the ratio of low-to-high spectral energy, and their respective standard deviations (SD). Data were also examined for relationships between acoustic measures and perceptual ratings of overall severity of voice quality. Results showed that perceived overall severity and the acoustic measures of the CPP and its SD (CPPsd) computed from sentence productions were significantly reduced at 2-week post-thyroidectomy for 20 patients (29%% of the sample) who had self-reported post-operative voice change. For this same group of patients, the CPP and CPPsd computed from sentence productions improved significantly from 2-weeks post-thyroidectomy to 6-months post-surgery. CPP and CPPsd also correlated well with perceived overall severity (r == --0.68 and --0.79, respectively). Measures of CPP from sustained vowel productions were not as effective as those from sentence productions in reflecting voice deterioration in the post-thyroidectomy patients at the 2-week post-surgery time period, were weaker correlates with perceived overall severity, and were not as effective in discriminating negative voice outcome (NegVO) from normal voice outcome (NormVO) patients as compared to the results from the sentence-level stimuli. Results indicate that spectral//cepstral analysis methods can be used with continuous speech samples to provide important objective data to document the effects of dysphonia in a post-thyroidectomy patient sample. When used in conjunction with patient's self-report and other general measures of vocal dysfunction, the acoustic measures employed in this study contribute to a complete profile of the patient's vocal condition.= 3 hours of extremity ischemia (P < .01). Conclusions: This study demonstrates the feasibility of combined hemorrhagic shock and extremity ischemia-reperfusion in a large-animal survival model. The presence of hemorrhagic shock compounds the effect of extremity ischemia, reducing the ischemic threshold of the limb to <3 hours. Strategies to improve functional salvage after extremity vascular injury in the setting of shock should include attempts at restoration of flow <= 60 minutes. (J Vasc Surg 2011;53:1052-62.) C1 [Stannard, Adam; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hancock, Heather M.; Stannard, Adam; Burkhardt, Gabriel E.; Williams, Ken; Dixon, Patti; Cowart, Jerry; Spencer, Jerry; Rasmussen, Todd E.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Stannard, Adam] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Ste B, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil FU Office of the Surgeon General of the United States Air Force FX Funding for this project was obtained from the Office of the Surgeon General of the United States Air Force. Expertise from Genesis Concepts and Consultants was utilized under USAF Contract No FA7014-09-D-0008. NR 28 TC 14 Z9 15 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD APR PY 2011 VL 53 IS 4 BP 1052 EP 1062 DI 10.1016/j.jvs.2010.10.104 PG 11 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 743IS UT WOS:000289012600024 PM 21255962 ER PT J AU Wroblewski, KJ Hidayat, AA Neafie, RC Rao, NA Zapor, M AF Wroblewski, Keith J. Hidayat, Ahmed A. Neafie, Ron C. Rao, Narsing A. Zapor, Michael TI Ocular Tuberculosis: A Clinicopathologic and Molecular Study SO OPHTHALMOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; MYCOBACTERIUM-TUBERCULOSIS; UVEITIS; INFECTION; PULMONARY; CHILDREN; ADULTS AB Objective: To analyze the clinical profiles, histopathologic features, and Mycobacterium tuberculosis polymerase chain reaction testing in patients with ocular tuberculosis. Design: Retrospective case series. Participants: Forty-two patients. Methods: This retrospective study was approved by the Armed Forces Institute of Pathology (AFIP) Institutional Review Board. The AFIP data banks were screened for cases with diagnosis of ocular tuberculosis using key words such as mycobacterium; tuberculosis; and acid-fast bacilli. Files and slides stained with hematoxylineosin and acid-fast staining were reviewed by the Division of Ocular Pathology and by the Infectious Diseases and Parasitic Diseases Pathology Branches. When available; blocks and unstained slides were sent to the Doheny Eye Institute; Los Angeles; California; for quantitative polymerase chain reaction (qPCR) analysis to detect Mycobacterium tuberculosis-specific DNA. Main Outcome Measures: Tuberculin skin test (TST) results, as well as the chest radiograph results, were recorded. When acid-fast bacilli were identified in tissue, their locations-ocular or extraocular sites-were recorded. Emphasis was placed on lymph node involvement and any systemic diseases. Results: In the histopathologic specimens, microscopy revealed a paucity of organisms, and often there were only 1 or 2 organisms associated with or near a giant cell or near an area of necrosis. The qPCR analysis was performed on 6 biopsy specimens. These specimens showed necrotizing granulomatous inflammation from 6 different patients; 3 had positive qPCR results. In 2 of the 3 cases with positive qPCR results, acid-fast bacilli were not found in the tissue sections. In 17 patients, TST results were available; 10 had positive results (60%) and 7 had negative results (40%). Fourteen chest radiograph results were submitted, and 8 (57%) of 14 patients had normal chest films. Conclusions: This study suggests that in dealing with those populations at increased risk of tuberculosis (e. g., immigrants from endemic areas and human immunodeficiency virus-infected patients) or patients receiving biologic therapy, the ophthalmologist should endeavor to entertain this diagnosis and to rely on the support of infectious disease specialists and pulmonologists to help solidify the diagnosis, because the current methods for the diagnosis have limited sensitivity. C1 [Wroblewski, Keith J.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Wroblewski, Keith J.; Hidayat, Ahmed A.; Neafie, Ron C.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Rao, Narsing A.] Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA. [Zapor, Michael] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Wroblewski, KJ (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 5000 Georgia Ave, Washington, DC 20307 USA. EM Keith.Wroblewski@amedd.army.mil NR 24 TC 22 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD APR PY 2011 VL 118 IS 4 BP 772 EP 777 DI 10.1016/j.ophtha.2010.08.011 PG 6 WC Ophthalmology SC Ophthalmology GA 744DS UT WOS:000289075200026 PM 21055814 ER PT J AU Natesan, S Zhang, G Baer, DG Walters, TJ Christy, RJ Suggs, LJ AF Natesan, Shanmugasundaram Zhang, Ge Baer, David G. Walters, Thomas J. Christy, Robert J. Suggs, Laura J. TI A Bilayer Construct Controls Adipose-Derived Stem Cell Differentiation into Endothelial Cells and Pericytes Without Growth Factor Stimulation SO TISSUE ENGINEERING PART A LA English DT Article ID SMOOTH-MUSCLE-CELLS; BONE-MARROW; FIBRIN GEL; IN-VITRO; 3-DIMENSIONAL MATRIX; TISSUE; ANGIOGENESIS; FIBROBLASTS; VIVO; TRANSPLANTATION AB This work describes the differentiation of adipose-derived mesenchymal stem cells (ASC) in a composite hydrogel for use as a vascularized dermal matrix. Our intent is that such a construct could be utilized following large-surface-area burn wounds that require extensive skin grafting and that are limited by the availability of uninjured sites. To develop engineered skin replacement constructs, we are pursuing the use of ASC. We have established that a PEGylated fibrin gel can provide a suitable environment for the proliferation of ASC over a 7 day time course. Further, we have demonstrated that PEGylated fibrin can be used to control ASC differentiation toward vascular cell types, including cells characteristic of both endothelial cells and pericytes. Gene expression analysis revealed strong upregulation of endothelial markers, CD31, and von Willebrand factor, up to day 11 in culture with corresponding evidence of protein expression demonstrated by immunocytochemical staining. ASC were not only shown to express endothelial cell phenotype, but a subset of the ASC expressed pericyte markers. The NG2 gene was upregulated over 11 days with corresponding evidence for the cell surface marker. Platelet-derived growth factor receptor beta gene expression decreased as the multipotent ASC differentiated up to day 7. Increased receptor expression at day 11 was likely due to the enhanced pericyte gene expression profile, including increased NG2 expression. We have also demonstrated that when cells are loaded onto chitosan microspheres and sandwiched between the PEGylated fibrin gel and a type I collagen gel, the cells can migrate and proliferate within the two different gel types. The matrix composition dictates the lineage specification and is not driven by soluble factors. Utilizing an insoluble bilayer matrix to direct ASC differentiation will allow for the development of both vasculature as well as dermal connective tissue from a single population of ASC. This work underscores the importance of the extracellular matrix in controlling stem cell phenotype. It is our goal to develop layered composites as wound dressings or vascularized dermal equivalents that are not limited by nutrient diffusion. C1 [Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Natesan, Shanmugasundaram; Baer, David G.; Walters, Thomas J.; Christy, Robert J.] US Army Inst Surg Res, Regenerat Med Res Program, Houston, TX USA. [Zhang, Ge] Univ Akron, Olson Res Ctr, Dept Biomed Engn, Akron, OH 44325 USA. RP Suggs, LJ (reprint author), Univ Texas Austin, Dept Biomed Engn, 1 Univ Stn, Austin, TX 78712 USA. EM laura.suggs@mail.utexas.edu OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Pittsburgh Tissue Engineering Initiative; University of Texas Health Science Center, San Antonio, TX [NIH-NCI P30 CA54174, NIH-NIA P30 AG013319, NIH-NIA P01AG19316]; Telemedicine and Advanced Technology Research Center (TATRC) at the U.S. Army Medical Research and Materiel Command (USAMRMC) [W81XWH-09-2-0103]; Deployment Related Medical Research Program (DRMRP) [W81XWH-09-1-0607] FX The authors would like to thank Ms. Janet Roe for isolation of adipose tissue and technical support. S. Natesan is supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative. Confocal images were generated in the core optical imaging facility, which is supported by the University of Texas Health Science Center, San Antonio, TX, NIH-NCI P30 CA54174 (San Antonio Cancer Institute), NIH-NIA P30 AG013319 (Nathan Shock Center, San Antonio, TX), and NIH-NIA P01AG19316. Funding for this work was provided by the Telemedicine and Advanced Technology Research Center (TATRC) at the U.S. Army Medical Research and Materiel Command (USAMRMC) through award W81XWH-09-2-0103 and the Deployment Related Medical Research Program (DRMRP) through award W81XWH-09-1-0607. The authors thank Dr. Robert Reddick, Medical Director, and Lauren Chesnut, Technical Director of the Electron Microscopy Facility at The University of Texas Health Science Center, Department of Pathology, for use of facility and assistance in the analysis of electron micrographs (EM). NR 52 TC 26 Z9 26 U1 0 U2 16 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD APR PY 2011 VL 17 IS 7-8 BP 941 EP 953 DI 10.1089/ten.tea.2010.0294 PG 13 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 741GX UT WOS:000288853300007 PM 21083419 ER PT J AU Wei, Q Pan, ZL Wu, XL Schuster, BE Kecskes, LJ Valiev, RZ AF Wei, Q. Pan, Z. L. Wu, X. L. Schuster, B. E. Kecskes, L. J. Valiev, R. Z. TI Microstructure and mechanical properties at different length scales and strain rates of nanocrystalline tantalum produced by high-pressure torsion SO ACTA MATERIALIA LA English DT Article DE Nanocrystalline; Tantalum; Microstructure; Mechanical properties; Adiabatic shear band ID CENTERED-CUBIC METALS; SEVERE PLASTIC-DEFORMATION; NONEQUILIBRIUM GRAIN-BOUNDARIES; HALL-PETCH BEHAVIOR; TENSILE BEHAVIOR; RATE SENSITIVITY; ULTRAFINE GRAIN; SHEAR BANDS; UNIAXIAL COMPRESSION; SCREW DISLOCATIONS AB Fully dense, nanocrystalline tantalum (average grain size as small as similar to 40 nm) has been processed for the first time by high-pressure torsion. High-resolution transmission electron microscopy reveals non-equilibrium grain boundaries and grains decorated with high-density dislocations. Microhardness measurements and instrumented nanoindentation experiments indicate that the mechanical property is quite uniform except for the central area of the disks. Nanoindentation experiments at different strain rates suggest that the strain rate sensitivity of nanocrystalline tantalum is increased compared to the coarse- and ultrafine-grained counterparts and is accompanied by an activation energy of the order of a few similar to b(3) (b is the magnitude of the dislocation Burgers vector), implying a shift in the plastic deformation mechanism from the screw dislocation dominated regime. We thus infer the plastic deformation mechanisms of nanocrystalline body-centered cubic (bcc) and face-centered cubic metals converge. To examine the stress strain behavior, we have used microcompression to measure the compressive stress strain curves on microscale pillars fabricated by focused ion beam technique. Yield strength as high as 1.6 GPa has been observed. High-strain rate behavior has been investigated using a miniature Kolsky bar system. We have found that at high-strain rates the nanocrystalline tantalum specimens exhibit adiabatic shear banding, a dynamic plastic deformation mode common to many ultrafine-grained and all nanocrystalline bcc metals. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Wei, Q.; Pan, Z. L.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Wu, X. L.] Chinese Acad Sci, Inst Mech, State Key Lab Non Linear Mech, Beijing 100190, Peoples R China. [Schuster, B. E.; Kecskes, L. J.] USA, Res Lab, Aberdeen, MD 21005 USA. [Valiev, R. Z.] Ufa State Aviat Technol Univ, Inst Phys Adv Mat, Ufa 450000, Russia. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn & Engn Sci, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Pan, Zhiliang/A-8061-2009; Kecskes, Laszlo/F-6880-2014 OI Pan, Zhiliang/0000-0003-3899-8761; Kecskes, Laszlo/0000-0002-1342-3729 FU US Army Research Laboratory [W911QX-06-C-0124]; NSFC [11021262, 11072243]; 973 Project [2010CB631004, 2009CB623700] FX This work was supported by US Army Research Laboratory under Contract # W911QX-06-C-0124. The authors would like to thank Mr. W.H. Yin for assistance in some experiments. They are also indebted to Drs. Z.G. Xu and S. Yarmolenko at NC A&T State University for assistance with microhardness, nanoindentation and XRD measurement. X.L.W. acknowledges the support of NSFC Grant Nos. 11021262, 11072243, and 973 Project Grants Nos. 2010CB631004 and 2009CB623700. NR 102 TC 55 Z9 56 U1 5 U2 93 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD APR PY 2011 VL 59 IS 6 BP 2423 EP 2436 DI 10.1016/j.actamat.2010.12.042 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 737KU UT WOS:000288568500017 ER PT J AU Mal, S Yang, TH Gupta, P Prater, JT Narayan, J AF Mal, Siddhartha Yang, Tsung-Han Gupta, P. Prater, J. T. Narayan, J. TI Thin film epitaxy and magnetic properties of STO/TiN buffered ZnO on Si(001) substrates SO ACTA MATERIALIA LA English DT Article DE Crystal growth; Laser deposition; Transmission electron microscopy (TEM); Electron-energy-loss spectroscopy (EELS); Magnetic thin films ID PLANE ZNO; GROWTH; DEPOSITION AB We report integration of epitaxial ZnO films with Si(0 0 1) substrates using STO/TiN buffer layers. It has been demonstrated that the preferential orientation of the a-plane (1 1 (2) over bar 0) and c-plane (0 0 0 2) of ZnO can be controlled via deposition temperature and oxygen partial pressure. At lower substrate temperatures ZnO grows solely in the (0 0 0 2) orientation, while the (1 1 (2) over bar 0) orientation was dominant at high substrate temperatures and low oxygen pressures. At higher pressures, the (0 0 0 2) orientation is preferred, while (1 1 (2) over bar 0) becomes weaker and a (1 0 (1) over bar 2) ZnO appears. Epitaxial relationships have been determined from X-ray diffraction phi-scans and it was found that both c- and a-ZnO had two types of orientations due to the cubic symmetry of the STO buffer layer. The orientation relationship of c-ZnO on STO(0 0 1) was ZnO(0 0 0 1) parallel to STO(1 0 0); ZnO[1 1 (2) over bar 0]parallel to STO[1 1 0] and ZnO[(1) over bar 2 (1) over bar 0] parallel to STO[(1) over bar 1 0], while that of a-ZnO on STO(0 0 1) was ZnO(1 1 (2) over bar 0) parallel to STO(1 0 0); ZnO[1 1 (2) over bar 0] parallel to STO[1 1 0] and ZnO[0 0 0 2] parallel to STO[(1) over bar 1 0]. High-resolution transmission electron microscopy studies revealed atomically sharp interfaces with no reaction at the interface. Reversible d(0) ferromagnetism was found to be present in both ZnO and STO layers. Our electron-energy-loss spectroscopy studies conclusively rule out the presence of any external ferromagnetic ions or impurities. Taken together, our data indicate that the ferromagnetic order in these undoped oxides might be defect mediated. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Mal, Siddhartha; Yang, Tsung-Han; Gupta, P.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu FU Army Research Office [W911NF-04-D-0003]; National Science Foundation [NSF 0653722] FX The authors acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003, and the National Science Foundation under Grant NSF 0653722. NR 30 TC 11 Z9 11 U1 6 U2 32 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD APR PY 2011 VL 59 IS 6 BP 2526 EP 2534 DI 10.1016/j.actamat.2010.12.058 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 737KU UT WOS:000288568500027 ER PT J AU Hall, JM Han, JJ Fadare, O AF Hall, Jordan M. Han, Jasmine J. Fadare, Oluwole TI The Value of Repeated Cytology at the Time of First Colposcopy A Retrospective Analysis of 1,087 Cases SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE Repeated cytology; Papanicolaou test; Colposcopy ID CERVICAL INTRAEPITHELIAL NEOPLASIA; PAP-SMEAR; INITIAL COLPOSCOPY; BIOPSY; LESION; WOMEN AB Papanicolaou tests are often repeated just before the procedure for women who have been referred for colposcopy. The validity and clinical usefulness of this practice, however, is unclear. We retrospectively assessed the value of repeated cytology in a cohort of 1,087 consecutive patients who underwent repeated Papanicolaou testing at first colposcopy. The repeated cytology was considered clinically useful if the results could conceivably have influenced the physician's decision about more invasive diagnostic/therapeutic evaluation based on contemporary practice guidelines. Repeated cytology provided potentially clinically useful information in only a small proportion (3.6%) of the cases analyzed overall, including 41% (26/63) and 1.8% of the high- and low-grade squamous intraepithelial lesions referral cytology cases, respectively. Our data indicate that repeated cytology provides potentially clinically useful information in only a small percentage of overall cases but a substantial proportion of high-grade squamous intraepithelial lesion referral cytology cases, suggesting that high-risk referral cytology case subsets can be defined wherein the routine performance of repeated cytology would be most efficacious. C1 [Fadare, Oluwole] Vanderbilt Univ, Dept Pathol, Med Ctr, Sch Med, Nashville, TN 37232 USA. [Hall, Jordan M.] Brian Allgood Army Community Hosp, Dept Pathol, Seoul, South Korea. [Han, Jasmine J.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Branch, Washington, DC 20307 USA. RP Fadare, O (reprint author), Vanderbilt Univ, Dept Pathol, Med Ctr, Sch Med, MCN C-2310D,1161 21st Ave S, Nashville, TN 37232 USA. NR 33 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD APR PY 2011 VL 135 IS 4 BP 628 EP 636 DI 10.1309/AJCP25UEVETXTNBF PG 9 WC Pathology SC Pathology GA 739AY UT WOS:000288685500015 PM 21411786 ER PT J AU Rohena, L Kuehn, D Marchegiani, S Higginson, JD AF Rohena, Luis Kuehn, Devon Marchegiani, Shannon Higginson, Jason D. TI Evidence for Autosomal Dominant Inheritance of Ablepharon-Macrostomia Syndrome SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE ablepharon-macrostomia; inheritance ID FAMILIAL OCCURRENCE; HYPERTRICHOSIS AB Ablepharon-macrostomia syndrome (AMS) is characterized by absent or short eyelids, macrostomia, ear anomalies, absent lanugo and hair, redundant skin, abnormal genitalia, and developmental delay in two-thirds of the reported patients. Additional anomalies include dry skin, growth retardation, hearing loss, camptodactyly, hypertelorism, absent zygomatic arches, and umbilical abnormalities. We present the second familial case of ablepharon-macrostomia syndrome in a newborn female and her 22-year-old father making autosomal dominant inheritance more likely than the previously proposed autosomal recessive transmission for this disorder. These cases likely represent the 16th and 17th reported cases of AMS and the first case suspected on prenatal ultrasound. Additionally, the child shows more prominent features of the disorder when compared to her father documenting variable expression and possible anticipation. Published 2011 Wiley-Liss, Inc.(dagger) C1 [Rohena, Luis; Kuehn, Devon; Marchegiani, Shannon; Higginson, Jason D.] Natl Capital Consortium, Dept Pediat, Bethesda, MD USA. RP Rohena, L (reprint author), Walter Reed Army Med Ctr, Georgia Ave NW, Washington, DC 20307 USA. EM luis.rohena@us.army.mil NR 18 TC 4 Z9 4 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD APR PY 2011 VL 155A IS 4 BP 850 EP 854 DI 10.1002/ajmg.a.33900 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA 740KP UT WOS:000288792700026 PM 21595001 ER PT J AU Forman, HP Larson, DB Kaye, AD Kazerooni, EA Norbash, A Crowe, JK Javitt, MC Beauchamp, NJ AF Forman, Howard P. Larson, David B. Kaye, Alan D. Kazerooni, Ella A. Norbash, Alexander Crowe, John K. Javitt, Marcia C. Beauchamp, Norman J., Jr. TI Masters of Radiology Panel Discussion: The Commoditization of Radiology SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE commoditization; competition; metrics; quality C1 [Forman, Howard P.] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA. [Larson, David B.] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Cincinnati, OH USA. [Kaye, Alan D.] Bridgeport Hosp, Dept Radiol, Westport, CT USA. [Kaye, Alan D.] Adv Radiol Consultants, Westport, CT USA. [Kazerooni, Ella A.] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. [Crowe, John K.] Scottsdale Med Imaging, Scottsdale, AZ USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. RP Forman, HP (reprint author), Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563 NR 2 TC 1 Z9 1 U1 0 U2 2 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD APR PY 2011 VL 196 IS 4 BP 843 EP 847 DI 10.2214/AJR.10.6393 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 738OP UT WOS:000288650600041 PM 21427333 ER PT J AU Holcomb, RE Mason, LJ Reardon, KF Cropek, DM Henry, CS AF Holcomb, Ryan E. Mason, Lucas J. Reardon, Kenneth F. Cropek, Donald M. Henry, Charles S. TI Culturing and investigation of stress-induced lipid accumulation in microalgae using a microfluidic device SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Microalgae; Microfluidics; Valves; Lipids; Biofuels; Cell culturing ID TETRASELMIS-CHUII; BIOLOGICAL CELLS; POLY(DIMETHYLSILOXANE); CHLOROPHYCEAE; TECHNOLOGIES; MICROCHIPS; METABOLISM; SYSTEMS; GROWTH; VALVES AB There is increasing interest in using microalgae as a lipid feedstock for the production of biofuels. Lipids used for these purposes are triacylglycerols that can be converted to fatty acid methyl esters (biodiesel) or decarboxylated to "green diesel." Lipid accumulation in most microalgal species is dependent on environmental stress and culturing conditions, and these conditions are currently optimized using slow, labor-intensive screening processes. Increasing the screening throughput would help reduce the development cost and time to commercial production. Here, we demonstrated an initial step towards this goal in the development of a glass/poly(dimethylsiloxane) (PDMS) microfluidic device capable of screening microalgal culturing and stress conditions. The device contained power-free valves to isolate microalgae in a microfluidic growth chamber for culturing and stress experiments. Initial experiments involved determining the biocompatibility and culturing capability of the device using the microalga Tetraselmis chuii. With this device, T. chuii could be successfully cultured for up to 3 weeks on-chip. Following these experiments, the device was used to investigate lipid accumulation in the microalga Neochloris oleabundans. It was shown that this microalga could be stressed to accumulate cytosolic lipids in a microfluidic environment, as evidenced with fluorescence lipid staining. This work represents the first example of microalgal culturing in a microfluidic device and signifies an important expansion of microfluidics into the biofuels research arena. C1 [Reardon, Kenneth F.; Henry, Charles S.] Colorado State Univ, Dept Chem & Biol Engn, Ft Collins, CO 80523 USA. [Holcomb, Ryan E.; Mason, Lucas J.; Henry, Charles S.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. [Cropek, Donald M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Henry, CS (reprint author), Colorado State Univ, Dept Chem & Biol Engn, Ft Collins, CO 80523 USA. EM chuck.henry@colostate.edu RI Reardon, Kenneth/A-1952-2016; OI Reardon, Kenneth/0000-0002-7753-4049; Henry, Charles/0000-0002-8671-7728 FU US Army Corps of Engineers from the Department of Energy [09-01, DE-FG02-08ER64622]; Sustainable Bioenergy Development Center at Colorado State University from the Department of Energy [09-01, DE-FG02-08ER64622] FX The authors thank Tara D. Schumacher for providing microalgae samples, culturing media, and relevant information regarding microalgal culturing. Additionally, the authors thank James T. Palmer for his rendering of Fig. 1a. Finally, the authors would like to thank Joshua M. Stillahn for his assistance in conducting profilometry measurements. This work was jointly funded by the US Army Corps of Engineers 6.2 Applied Research Program and the Sustainable Bioenergy Development Center at Colorado State University (Grant 09-01) through contract DE-FG02-08ER64622 from the Department of Energy. NR 26 TC 22 Z9 23 U1 3 U2 51 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD APR PY 2011 VL 400 IS 1 BP 245 EP 253 DI 10.1007/s00216-011-4710-3 PG 9 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 738RC UT WOS:000288658800026 PM 21311874 ER PT J AU Li, YF Efferson, CL Ramesh, R Peoples, GE Hwu, P Ioannides, CG AF Li, Yufeng Efferson, Clay L. Ramesh, Rajagopal Peoples, George E. Hwu, Patrick Ioannides, Constantin G. TI A peptidoglycan monomer with the glutamine to serine change and basic peptides bind in silico to TLR-2 (403-455) SO CANCER IMMUNOLOGY IMMUNOTHERAPY LA English DT Article DE PGN monomers; Charged peptides; Bind TLR-2; Molecular simulation ID TOLL-LIKE RECEPTOR-2; STAPHYLOCOCCUS-AUREUS PEPTIDOGLYCAN; CRYSTAL-STRUCTURE; RECOGNITION PROTEINS; DENDRITIC CELLS; TOLL-LIKE-RECEPTOR-2; ACTIVATION; ANTIGEN; INNATE AB Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation. We found that the peptides containing basic amino acids (cations) at N -terminus and tyrosine at C-terminus interfered with activating ability of PGN. This finding is significant because the ECD of TLR-2 in vivo encounters a large number of proteins or peptides. Some should bind ECD and "pre-form" TLR-2 to respond or not to its activators, although they cannot activate TLR-2 alone. TLR-2 is receptor for a large number of ligands, including lipopeptides and bacterial cell wall glycoproteins. A binding site for lipopeptides has been identified; however, a binding site for soluble or multimeric PGN has not been proposed. To identify the candidate binding sites of peptides and PGN on TLR-2, we modeled docking of peptides and of the PGN monomer (PGN-S-monomer) to extracellular domain (ECD-TLR-2) of the unbound TLR-2. Quantification, in silico, of free energy of binding (DG) identified 2 close sites for peptides and PGN. The PGN-S-monomer binding site is between amino acids TLR-2, 404-430 or more closely TLR-2, 417-428. The peptide-binding site is between amino acids TLR-2, 434-455. Molecular models show PGN-S-monomer inserts its N -acetyl-glucosamine (NAG) deep in the TLR-2 coil, while its terminal lysine interacts with inside (Glu(403)) and outside pocket (Tyr(378)). Peptides insert their two N -terminal arginines or their C-terminal tyrosines in the TLR-2 coil. PGN did not bind the lipopeptide-binding site in the TLR-2. It can bind the C-terminus, 572-586 (DG = 0.026 kcal), of "lipopeptide-bound" TLR-2. An additional, low-affinity PGN-binding site is TLR-2 (227-237). MTP, MDP, and lysine-less PGN bind to TLR-2, 87-113. This is the first report identifying candidate binding sites of monomer PGN and peptides on TLR-2. Experimental verification of our findings is needed to create synthetic adjuvant for vaccines. Such synthetic PGN can direct both adjuvant and cancer antigen to TLR-2. C1 [Li, Yufeng; Hwu, Patrick] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA. [Efferson, Clay L.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. [Ramesh, Rajagopal] Univ Texas MD Anderson Canc Ctr, Dept Thorac Surg, Houston, TX 77030 USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Houston, TX 78234 USA. [Li, Yufeng; Ioannides, Constantin G.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. RP Li, YF (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA. EM yim_lee80@hotmail.com; cioannid@mdanderson.org FU Apthera Corporation FX This research was supported by License funds for Discretionary research from Apthera Corporation. NR 31 TC 5 Z9 5 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-7004 J9 CANCER IMMUNOL IMMUN JI Cancer Immunol. Immunother. PD APR PY 2011 VL 60 IS 4 BP 515 EP 524 DI 10.1007/s00262-010-0959-1 PG 10 WC Oncology; Immunology SC Oncology; Immunology GA 737GI UT WOS:000288556700007 PM 21188584 ER PT J AU Pan, YL Berg, MJ Zhang, SSM Noh, H Cao, H Chang, RK Videen, G AF Pan, Yong-Le Berg, Matthew J. Zhang, Samuel Shao-Min Noh, Heeso Cao, Hui Chang, Richard K. Videen, Gorden TI Measurement and Autocorrelation Analysis of Two-Dimensional Light-Scattering Patterns from Living Cells for Label-Free Classification SO CYTOMETRY PART A LA English DT Article DE elastic scattering pattern; autocorrelation; label-free; cell ID FLOW-CYTOMETRY; AEROSOL; SPECKLE; SENSITIVITY; INSTRUMENT; PARTICLES; SHAPE AB We incorporate optics and an ICCD to record the two-dimensional angular optical scattering (TAOS) patterns retrieved from single aerosolized cells. We analyze these patterns by performing autocorrelations and demonstrate that we are able to retrieve cell size from the locations of the secondary maxima. Additional morphological information is contained in the autocorrelation functions and decay rate of the heights of the autocorrelation peaks. We demonstrate these techniques with C6 and Y79 cells, which are readily distinguishable. One key advantage of this methodology is that there is no requirement for antibody and fluorescent labeling molecules. Published 2011 Wiley-Liss, Inc.(dagger) C1 [Pan, Yong-Le; Berg, Matthew J.; Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. [Berg, Matthew J.] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Zhang, Samuel Shao-Min] Penn State Milton S Hershey Med Ctr, Dept Neural & Behav Sci, Hershey, PA 17033 USA. [Noh, Heeso; Cao, Hui; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. RP Pan, YL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM yongle.pan@arl.army.mil RI Cao, Hui/F-4815-2012; Noh, Heeso/F-4803-2012 OI Noh, Heeso/0000-0002-6086-9109 FU NSF [DMR-0808937]; Defense Threat Reduction Agency; US Army Research Laboratory; Penn State University FX Grant sponsor: NSF; Grant number: DMR-0808937; Grant sponsors: Defense Threat Reduction Agency (Physical Science and Technology Basic Research Program), the US Army Research Laboratory mission fund, Penn State University Start-up Funds. NR 32 TC 13 Z9 14 U1 5 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4922 J9 CYTOM PART A JI Cytom. Part A PD APR PY 2011 VL 79A IS 4 BP 284 EP 292 DI 10.1002/cyto.a.21036 PG 9 WC Biochemical Research Methods; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 741IY UT WOS:000288858600007 PM 21387543 ER PT J AU Witzel, J AF Witzel, John TI Experiments with a Cat-5 Cable SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material C1 [Witzel, John] USA, Washington, DC USA. EM john.witzel@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD APR PY 2011 VL 14 IS 2 BP 54 EP 56 PG 3 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 738TB UT WOS:000288664100010 ER PT J AU Anandkumar, A Michael, N Tang, K Swami, A AF Anandkumar, Animashree Michael, Nithin Tang, Kevin Swami, Ananthram TI Distributed Algorithms for Learning and Cognitive Medium Access with Logarithmic Regret SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Cognitive medium access control; multi-armed bandits; distributed algorithms; logarithmic regret ID MULTIARMED BANDIT PROBLEM; EFFICIENT ALLOCATION RULES; MULTIPLE PLAYS; REWARDS AB The problem of distributed learning and channel access is considered in a cognitive network with multiple secondary users. The availability statistics of the channels are initially unknown to the secondary users and are estimated using sensing decisions. There is no explicit information exchange or prior agreement among the secondary users and sensing and access decisions are undertaken by them in a completely distributed manner. We propose policies for distributed learning and access which achieve order-optimal cognitive system throughput (number of successful secondary transmissions) under self play, i.e., when implemented at all the secondary users. Equivalently, our policies minimize the sum regret in distributed learning and access, which is the loss in secondary throughput due to learning and distributed access. For the scenario when the number of secondary users is known to the policy, we prove that the total regret is logarithmic in the number of transmission slots. This policy achieves order-optimal regret based on a logarithmic lower bound for regret under any uniformly-good learning and access policy. We then consider the case when the number of secondary users is fixed but unknown, and is estimated at each user through feedback. We propose a policy whose sum regret grows only slightly faster than logarithmic in the number of transmission slots. C1 [Anandkumar, Animashree] Univ Calif Irvine, Ctr Pervas Commun & Comp, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. [Michael, Nithin; Tang, Kevin] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Anandkumar, A (reprint author), Univ Calif Irvine, Ctr Pervas Commun & Comp, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. EM a.anandkumar@uci.edu; nm373@ece.cornell.edu; atang@ece.cornell.edu; a.swami@ieee.org FU MURI through AFOSR [FA9550-06-1-0324]; NSF [CCF-0835706] FX Manuscript received 1 December 2009; revised 4 June 2010. During the stint of this work, the first author was supported by MURI through AFOSR Grant FA9550-06-1-0324. The second and the third authors are supported in part through NSF grant CCF-0835706. Parts of this paper were presented at [1]. NR 25 TC 66 Z9 66 U1 2 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD APR PY 2011 VL 29 IS 4 BP 731 EP 745 DI 10.1109/JSAC.2011.110406 PG 15 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 739ZY UT WOS:000288762300006 ER PT J AU Ren, W Zhao, Q Swami, A AF Ren, Wei Zhao, Qing Swami, Ananthram TI On the Connectivity and Multihop Delay of Ad Hoc Cognitive Radio Networks SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Cognitive radio network; multihop delay; connectivity; intermittent connectivity; continuum percolation; ergodic theory ID WIRELESS NETWORKS; CAPACITY; TRADEOFFS AB We analyze the multihop delay of ad hoc cognitive radio networks, where the transmission delay of each hop consists of the propagation delay and the waiting time for the availability of the communication channel (i.e., the occurrence of a spectrum opportunity at this hop). Using theories and techniques from continuum percolation and ergodicity, we establish the scaling law of the minimum multihop delay with respect to the source-destination distance in cognitive radio networks. When the propagation delay is negligible, we show the starkly different scaling behavior of the minimum multihop delay in instantaneously connected networks as compared to networks that are only intermittently connected due to scarcity of spectrum opportunities. Specifically, if the network is instantaneously connected, the minimum multihop delay is asymptotically independent of the distance; if the network is only intermittently connected, the minimum multihop delay scales linearly with the distance. When the propagation delay is nonnegligible but small, we show that although the scaling order is always linear, the scaling rate for an instantaneously connected network can be orders of magnitude smaller than the one for an intermittently connected network. C1 [Ren, Wei; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Ren, W (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM qzhao@ucdavis.edu FU Army Research Laboratory [DAAD19-01-C-0062]; NS-CTA [W911NF-09-2-0053]; National Science Foundation [CCF-0830685] FX Manuscript received 1 December 2009; revised 31 May 2010 and 30 June 2010. This work was supported in part by the Army Research Laboratory under Grant DAAD19-01-C-0062 and the NS-CTA Grant W911NF-09-2-0053, and by the National Science Foundation under Grant CCF-0830685. Part of this work was presented at 2010 ICC. NR 30 TC 23 Z9 23 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 EI 1558-0008 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD APR PY 2011 VL 29 IS 4 BP 805 EP 818 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 739ZY UT WOS:000288762300012 ER PT J AU Sakushima, K Hayashino, Y Kawaguchi, T Jackson, JL Fukuhara, S AF Sakushima, Ken Hayashino, Yasuaki Kawaguchi, Takehiko Jackson, Jeffrey L. Fukuhara, Shunichi TI Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: A meta-analysis SO JOURNAL OF INFECTION LA English DT Review DE Meningitis; Cerebrospinal fluid; Lactate; Meta-analysis ID LACTIC-ACID LEVELS; CSF LACTATE; RAPID DIAGNOSIS; ANTIBIOTIC-THERAPY; LABORATORY TESTS; VIRAL MENINGITIS; UNITED-STATES; ADULTS; CHILDREN; DISEASES AB Objectives: Cerebrospinal fluid (CSF) lactate is produced by bacterial anaerobic metabolism and is not affected by blood lactate concentration, an advantage over CSF glucose in differentiating bacterial meningitis from aseptic meningitis. However, the previous investigations have shown mixed results of the sensitivity and specificity. Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis. Methods: We searched MEDLINE and EMBASE for clinical studies that included CSF lactate measurement in bacterial meningitis and aseptic meningitis. Test characteristics were pooled using hierarchical summary ROC curve and random effects model. Results: Thirty three studies were included. The pooled test characteristics of CSF lactate were sensitivity 0.93 (95% CI: 0.89-0.96), specificity 0.96 (95% CI: 0.93-0.98), likelihood ratio positive 22.9 (95% CI: 12.6-41.9), likelihood ratio negative 0.07 (95% CI: 0.05-0.12), and diagnostic odds ratio 313 (95% CI: 141-698). Pretreatment with antibiotics lowered the sensitivity 0.49 (95% CI: 0.23-0.75). CSF lactate of around 35 mg/dl (34-36 mg/dl) had higher sensitivity and specificity than those of around 27 mg/dl (26-28 mg/dl). Conclusions: CSF lactate's high negative likelihood ratio may make it useful for ruling out bacterial meningitis though pretreatment with antibiotics reduces clinical accuracy. CSF lactate of 35mg/dl could be optimal cut-off value for distinguishing bacterial meningitis from aseptic meningitis. (c) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved. C1 [Sakushima, Ken] Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan. [Sakushima, Ken; Hayashino, Yasuaki; Fukuhara, Shunichi] Kyoto Univ, Grad Sch Med & Publ Hlth, Dept Epidemiol & Healthcare Res, Kyoto 6068501, Japan. [Kawaguchi, Takehiko] Japan Red Cross Nagoya Daini Hosp, Dept Nephrol, Nagoya, Aichi, Japan. [Jackson, Jeffrey L.] Walter Reed Army Med Ctr, Dept Med, Washington, DC USA. RP Sakushima, K (reprint author), Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan. EM sakusima@med.hokudai.ac.jp OI Hayashino, Yasuaki/0000-0002-2932-8478 NR 59 TC 47 Z9 56 U1 0 U2 6 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 J9 J INFECTION JI J. Infect. PD APR PY 2011 VL 62 IS 4 BP 255 EP 262 DI 10.1016/j.jinf.2011.02.010 PG 8 WC Infectious Diseases SC Infectious Diseases GA 741FX UT WOS:000288850300001 PM 21382412 ER PT J AU Meng, CY Smith, BL Bodhidatta, L Richard, SA Vansith, K Ban, T Srijan, A Serichantalergs, O Mason, CJ AF Meng, Chhour Y. Smith, Bryan L. Bodhidatta, Ladaporn Richard, Stephanie A. Vansith, Ket Ban Thy Srijan, Apichai Serichantalergs, Oralak Mason, Carl J. TI Etiology of Diarrhea in Young Children and Patterns of Antibiotic Resistance in Cambodia SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE diarrhea; antibiotic; rotavirus; children; Cambodia ID ENTEROAGGREGATIVE ESCHERICHIA-COLI; CAMPYLOBACTER-JEJUNI; THAI CHILDREN; DISEASE; PATHOGENS; SUSCEPTIBILITY; INDONESIA; VIETNAM; CELLS; PROBE AB Background: Little is known about diarrhea etiology and antibiotic resistance in developing countries where diarrhea is a major public health problem. Methods: To describe diarrhea etiology and antibiotic resistance patterns in Cambodia, 600 children aged 3 months to 5 years with acute diarrhea (cases) and 578 children without diarrhea (controls) were enrolled from a hospital in Phnom Penh. Stool samples were collected, and pathogens and antibiotic resistance patterns were described. Results: The most frequently isolated pathogens in these cases were enteroaggregative Escherichia coli (20%) and rotavirus (26%). Enterotoxigenic E. coli, enteroaggregative E. coli, Shigella, Aeromonas, rotavirus, and adenovirus were statistically significantly associated with diarrhea. Among cases, vomiting was associated with viral infections, whereas bloody stool was associated with Shigella. Enterotoxigenic E. coli isolates were highly resistant to ampicillin, sulfonamides, and tetracycline. Approximately 50% of Campylobacter coli and 30% of Campylobacter jejuni isolates were resistant to nalidixic acid and ciprofloxacin. Over 33% of Salmonella isolates were resistant to ampicillin and tetracycline, and almost 100% of Shigella isolates were resistant to trimethoprim/sulfamethoxazole. Conclusions: These data on the etiology of diarrhea and antibiotic resistance patterns in Cambodia will have significant effect on local public health policies and on local resource prioritization practices. C1 [Bodhidatta, Ladaporn; Srijan, Apichai; Serichantalergs, Oralak; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Smith, Bryan L.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Meng, Chhour Y.; Vansith, Ket; Ban Thy] Natl Pediat Hosp, Phnom Penh, Cambodia. [Richard, Stephanie A.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Richard, Stephanie A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM ladapornb@afrims.org RI Valle, Ruben/A-7512-2013; OI MASON, CARL/0000-0002-3676-2811 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, Washington, DC FX Supported by Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, Washington, DC. NR 32 TC 34 Z9 37 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD APR PY 2011 VL 30 IS 4 BP 331 EP 335 DI 10.1097/INF.0b013e3181fb6f82 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 735SU UT WOS:000288438700014 PM 21412204 ER PT J AU Cole, SZ Lanham, JS AF Cole, Sarah Z. Lanham, Jason S. TI Failure to Thrive: An Update SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID PROSPECTIVE BIRTH COHORT; DENSE FORMULA; WEIGHT-GAIN; CHILDREN; INFANTS; GROWTH; CHILDHOOD; UNDERNUTRITION; IDENTIFICATION; MALNUTRITION AB Failure to thrive in childhood is a state of undernutrition due to inadequate caloric intake, inadequate caloric absorption, or excessive caloric expenditure. In the United States, it is seen in 5 to 10 percent of children in primary care settings. Although failure to thrive is often defined as a weight for age that falls below the 5th percentile on multiple occasions or weight deceleration that crosses two major percentile lines on a growth chart, use of any single indicator has a low positive predictive value. Most cases of failure to thrive involve inadequate caloric intake caused by behavioral or psychosocial issues. The most important part of the outpatient evaluation is obtaining an accurate account of a child's eating habits and caloric intake. Routine laboratory testing rarely identifies a cause and is not generally recommended. Reasons to hospitalize a child for further evaluation include failure of outpatient management, suspicion of abuse or neglect, or severe psychosocial impairment of the caregiver. A multidisciplinary approach to treatment, including home nursing visits and nutritional counseling, has been shown to improve weight gain, parent-child relationships, and cognitive development. The long-term effects of failure to thrive on cognitive development and future academic performance are unclear. (Am Fam Physician. 2011;83(7):829-834. Copyright (C) 2011 American Academy of Family Physicians.) C1 [Cole, Sarah Z.] St Johns Mercy Med Ctr, St Louis, MO 63141 USA. [Lanham, Jason S.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Cole, SZ (reprint author), St Johns Mercy Med Ctr, 12680 Olive Blvd,Ste 300, St Louis, MO 63141 USA. NR 41 TC 22 Z9 23 U1 0 U2 17 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 1 PY 2011 VL 83 IS 7 BP 829 EP 834 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 979ZO UT WOS:000306863600007 PM 21524049 ER PT J AU Atkins, JL Gorbunov, NV Trabosh, V Van Duyne, R Kashanchi, F Komarov, AM AF Atkins, James L. Gorbunov, Nikolai V. Trabosh, Valerie Van Duyne, Rachel Kashanchi, Fatah Komarov, Andrei M. TI Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitation SO BIOMETALS LA English DT Article DE Ferrous iron; TIMP-2; Hemorrhage; Extracellular ID TRAUMA-HEMORRHAGIC SHOCK; ISCHEMIA/REPERFUSION-INJURY; ENDOTHELIAL-CELLS; FREE-RADICALS; NITRIC-OXIDE; ACTIVATION; RAT; DEFEROXAMINE; REPERFUSION; INTESTINE AB Extracellular iron has been implicated in the pathogenesis of post-injury organ failure. However, the source(s) and biochemical species of this iron have not been identified. Based upon evidence that distant organ injury results from an increase in intestinal permeability, we looked for ferrous iron in mesenteric lymph in anesthetized rats undergoing hemorrhage and fluid resuscitation (H/R). Ferrous iron increased in lymph from 4.7 nmol/mg of protein prior to hemorrhage to 86.6 nmol/mg during resuscitation. Utilizing immuno-spin trapping in protein fractions that were rich in iron, we tentatively indentified protein carrier(s) of ferrous iron by MALDI-TOF MS. One of the identified proteins was the metalloproteinase (MMP) inhibitor, TIMP-2. Antibody to TIMP-2 immunoprecipitated 74% of the ferrozine detectable iron in its protein fraction. TIMP-2 binds iron in vitro at pH 6.3, which is typical of conditions in the mesentery during hemorrhage, but it retains the ability to inhibit the metalloproteases MMP-2 and MMP-9. In summary, there is a large increase in extracellular ferrous iron in the gut in H/R demonstrating dysregulation of iron homeostasis. We have identified, for the first time, the binding of extracellular iron to TIMP-2. C1 [Atkins, James L.; Trabosh, Valerie] Walter Reed Army Inst Res, Closed Head Brain Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Gorbunov, Nikolai V.] Advancement Mil Med Inc, Henry M Jackson Fdn, Bethesda, MD 20889 USA. [Van Duyne, Rachel; Kashanchi, Fatah] George Mason Univ, Natl Ctr Biodef & Infect Dis, Dept Mol & Microbiol, Manassas, VA 20110 USA. [Van Duyne, Rachel; Kashanchi, Fatah; Komarov, Andrei M.] George Washington Univ, Med Ctr, Washington, DC 20037 USA. RP Atkins, JL (reprint author), Walter Reed Army Inst Res, Closed Head Brain Injury Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jim.atkins@us.army.mil FU Department of the Army [PR033201] FX We wish to thank Dr. Edwin A. Deitch for advice on the technique for the cannulation of mesenteric lymphatics and Sara Smith for her excellent technical assistance. This work was supported by the Department of the Army Peer Reviewed Medical Research Program, no. PR033201 (Atkins). NR 44 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0966-0844 J9 BIOMETALS JI Biometals PD APR PY 2011 VL 24 IS 2 BP 279 EP 289 DI 10.1007/s10534-010-9394-1 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 735BF UT WOS:000288387700008 PM 21229381 ER PT J AU Andersen, NE McClung, HL Fielding, RA McClung, JP Young, AJ Pasiakos, SM AF Andersen, Nancy E. McClung, Holly L. Fielding, Roger A. McClung, James P. Young, Andrew J. Pasiakos, Stefan M. TI Moderate endurance exercise affects hepcidin and IL-6 levels in healthy young men SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Andersen, Nancy E.; McClung, Holly L.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Fielding, Roger A.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403350 ER PT J AU Bass, LJ Karl, JP Rood, JC Cable, SJ Williams, KW Young, AJ McClung, JP AF Bass, Laura Jean Karl, J. Philip Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Vitamin D status and biomarkers of bone health in female Soldiers during military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Bass, Laura Jean; Karl, J. Philip; Young, Andrew J.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708407175 ER PT J AU Bhattacharjee, AK Marek, E Le, HT Ku, T Gordon, RK AF Bhattacharjee, Apurba Krishna Marek, Elizabeth Ha Thu Le Ku, Therese Gordon, Richard K. TI Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for tabun-inhibited acetylcholinesterase SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Bhattacharjee, Apurba Krishna; Marek, Elizabeth; Ha Thu Le; Ku, Therese; Gordon, Richard K.] Walter Reed Army Inst Res, Regulated Act DRA, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708406733 ER PT J AU Cartagena, CM Phillips, KL Tong, M Tortella, FC Dave, JR AF Cartagena, Casandra M. Phillips, Katie L. Tong, Min Tortella, Frank C. Dave, Jitendra R. TI Changes in Apoptotic Mechanisms Following Penetrating Ballistic-like Brain Injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Cartagena, Casandra M.; Phillips, Katie L.; Tong, Min; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708400052 ER PT J AU Chakraborty, N De Lima, T Meyerhoff, J Muhie, S Gautam, A Jibitu, M Jett, M Hammamieh, R AF Chakraborty, Nabarun De Lima, Thereza Meyerhoff, James Muhie, Seid Gautam, Aarti Jibitu, Meskerem Jett, Marti Hammamieh, Rasha TI Comparative analysis of behavioral cues and brain functionality associated with mice in a model simulating aspects of PTSD SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Chakraborty, Nabarun; Meyerhoff, James; Muhie, Seid; Gautam, Aarti; Jibitu, Meskerem; Jett, Marti; Hammamieh, Rasha] Walter Reed Army Inst Res, Silver Spring, MD USA. [De Lima, Thereza] Univ Fed Santa Catarina, BR-88040900 Florianopolis, SC, Brazil. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404314 ER PT J AU Cope, EC VanLandingham, JW Scrimgeour, AG Condlin, ML Gower-Winter, SD Levenson, CW AF Cope, Elise C. VanLandingham, Jacob W. Scrimgeour, Angus G. Condlin, Michelle L. Gower-Winter, Shannon D. Levenson, Cathy W. TI Zinc supplementation prevents depression and deficits in spatial learning and memory associated with traumatic brain injury in the rat SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Cope, Elise C.; VanLandingham, Jacob W.; Gower-Winter, Shannon D.; Levenson, Cathy W.] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA. [Scrimgeour, Angus G.; Condlin, Michelle L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Levenson, Cathy W.] Program Neurosci, Tallahassee, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708401893 ER PT J AU Demar, JC Somerville, SM Ratcliffe, RH Logeman, LM Ku, TC Nur, NM Ursic, BM Gordon, RK AF Demar, James C. Somerville, Shahza M. Ratcliffe, Ruthie H. Logeman, Laura M. Ku, Therese C. Nur, Nur M. Ursic, Benjamin M. Gordon, Richard K. TI Comparison of brain protection in rats and guinea pigs by pro-2-pralidoxime (pro-2-PAM) to organophosphate exposure SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Demar, James C.; Somerville, Shahza M.; Ratcliffe, Ruthie H.; Logeman, Laura M.; Ku, Therese C.; Nur, Nur M.; Ursic, Benjamin M.; Gordon, Richard K.] Walter Reed Army Inst Res, DRA, Regulated Labs, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404732 ER PT J AU Dubick, MA Barr, JL Baer, LA Wu, XW Wade, CE AF Dubick, Michael A. Barr, Johnny L. Baer, Lisa A. Wu, Xiaowu Wade, Charles E. TI Effects of high protein feeding and insulin on liver antioxidant status in rats subjected to burn injury and hindlimb unloading (HU) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Dubick, Michael A.; Barr, Johnny L.; Baer, Lisa A.; Wu, Xiaowu; Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403792 ER PT J AU Fulgoni, V Keast, DR Lieberman, HR AF Fulgoni, Victor, III Keast, Debra R. Lieberman, Harris R. TI Usual caffeine intake of US adults: An analysis of NHANES data from 2003-2008 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Fulgoni, Victor, III] Nutr Impact LLC, Battle Creek, MI USA. [Keast, Debra R.] Food & Nutr Database Res Inc, Okemos, MI USA. [Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 7 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708402222 ER PT J AU Gautam, A Muhie, S Hammamieh, R Jett, M AF Gautam, Aarti Muhie, Seid Hammamieh, Rasha Jett, Marti TI Metabolomic analysis and signatures in mouse model of post traumatic stress disorder SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Gautam, Aarti; Muhie, Seid; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404558 ER PT J AU Gautam, A Hammamieh, R Filippov, A Jett, M AF Gautam, Aarti Hammamieh, Rasha Filippov, Andrey Jett, Marti TI Use of the genomic library of short interfering RNA to block vascular collapse from the exposure to diverse pathogenic agents SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Gautam, Aarti; Hammamieh, Rasha; Filippov, Andrey; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404123 ER PT J AU Gribok, AV Rumpler, W Buller, M Hoyt, R AF Gribok, Andrei V. Rumpler, William Buller, Mark Hoyt, Reed TI Predicting core temperature in humans using autoregressive model with exogenous inputs SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Gribok, Andrei V.; Rumpler, William] ARS, Food Intake & Energy Regulat Lab, Beltsville Human Nutr Ctr, USDA, Beltsville, MD USA. [Buller, Mark; Hoyt, Reed] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708400752 ER PT J AU Hamilton, L Bonvillain, A Myers, T AF Hamilton, Lindsey Bonvillain, Andrew Myers, Todd TI Time course, safety, and efficacy of reversible acetylcholinesterase inhibitors in cynomolgus macaques SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Hamilton, Lindsey; Bonvillain, Andrew; Myers, Todd] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403463 ER PT J AU Hammamieh, R Muhie, S Miller, SA Jett, M AF Hammamieh, Rasha Muhie, Seid Miller, Stacy-Ann Jett, Marti TI Integromic Approaches to define Networks and Biomarkers to Pathogens SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Hammamieh, Rasha; Muhie, Seid; Miller, Stacy-Ann; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404122 ER PT J AU Helwig, BG Blaha, MD Majkut, NM Jones, LD Leon, LR AF Helwig, Bryan G. Blaha, Michael D. Majkut, Nicole M. Jones, Lisa D. Leon, Lisa R. TI The spleen as a potential source of IL-1 family cytokines following heat stroke SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Helwig, Bryan G.; Blaha, Michael D.; Majkut, Nicole M.; Jones, Lisa D.; Leon, Lisa R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403409 ER PT J AU Hinojosa-Laborde, C Rickards, C Ryan, K Convertino, V AF Hinojosa-Laborde, Carmen Rickards, Caroline Ryan, Kathy Convertino, Victor TI Heart period variability responses during simulated hemorrhage in high and low tolerant subjects SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Hinojosa-Laborde, Carmen; Ryan, Kathy; Convertino, Victor] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline] Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403901 ER PT J AU Karl, JP Bass, LJ Pasiakos, SM Andersen, NE Margolis, LM Rood, JC Cable, SJ Williams, KW McClung, JP AF Karl, J. Philip Bass, Laura J. Pasiakos, Stefan M. Andersen, Nancy E. Margolis, Lee M. Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. McClung, James P. TI Cardiometabolic risk in US Army recruits and the effects of military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Karl, J. Philip; Bass, Laura J.; Pasiakos, Stefan M.; Andersen, Nancy E.; Margolis, Lee M.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. RI McClung, James/A-1989-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708406969 ER PT J AU Keast, DR Fulgoni, VL Lieberman, HR AF Keast, Debra R. Fulgoni, Victor L., III Lieberman, Harris R. TI Dietary sources of caffeine intake by US adults in the 2001-2008 NHANES SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Keast, Debra R.] Food & Nutr Database Res Inc, Okemos, MI USA. [Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403017 ER PT J AU Kenefick, RW Cheuvront, SN Elliott, LD Ely, BR Sawka, MN AF Kenefick, Robert W. Cheuvront, Samuel N. Elliott, Leonard D. Ely, Brett R. Sawka, Michael N. TI Biological variation of local sweating measures during exercise-heat stress in heat acclimated humans SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Kenefick, Robert W.; Cheuvront, Samuel N.; Elliott, Leonard D.; Ely, Brett R.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708400763 ER PT J AU Kheirabadi, BS Hardin, MO Terrazas, IB Valdez, KK Hanson, MA Dubick, MA AF Kheirabadi, Bijan Shams Hardin, Mark O. Terrazas, Irasema B. Valdez, Krystal K. Hanson, Margaret A. Dubick, Michael A. TI Preliminary risk and benefit analysis of the intracorporeal use of Combat Gauze,, SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Kheirabadi, Bijan Shams; Hardin, Mark O.; Terrazas, Irasema B.; Valdez, Krystal K.; Hanson, Margaret A.; Dubick, Michael A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708407183 ER PT J AU Klein, R Daily, S Jett, M Mendis, C AF Klein, Rebecca Daily, Sarah Jett, Marti Mendis, Chanaka TI EFFECT OF PATHWAY-INTERCONNECTORS IN SEB-INDUCED APOPTOSIS RELATED EVENTS IN HUMAN PBMCS SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Klein, Rebecca; Daily, Sarah; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708406633 ER PT J AU Leon, LR Blaha, MD Helwig, BG AF Leon, Lisa R. Blaha, Michael D. Helwig, Bryan G. TI Altered Heat Stroke Inflammatory Responses in TNF Double Receptor Knockout Mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Leon, Lisa R.; Blaha, Michael D.; Helwig, Bryan G.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403426 ER PT J AU Lieberman, HR Stavinoha, TB McGraw, SM White, A Hadden, LS Marriott, BP AF Lieberman, Harris R. Stavinoha, Trisha B. McGraw, Susan M. White, Alan Hadden, Louise S. Marriott, Bernadette P. TI Caffeine consumption in active duty US Army personnel SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Lieberman, Harris R.; Stavinoha, Trisha B.; McGraw, Susan M.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [White, Alan; Hadden, Louise S.; Marriott, Bernadette P.] ABT Associates Inc, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708402223 ER PT J AU McClung, HL Margolis, LM McClung, JP Andersen, NE Cloutier, GJ Pikosky, MA Fielding, RA Young, AJ Pasiakos, SM AF McClung, Holly L. Margolis, Lee M. McClung, James P. Andersen, Nancy E. Cloutier, Gregory J. Pikosky, Matthew A. Fielding, Roger A. Young, Andrew J. Pasiakos, Stefan M. TI Leucine supplementation affects mTORC1 signaling following moderate endurance exercise SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [McClung, Holly L.; Margolis, Lee M.; McClung, James P.; Andersen, Nancy E.; Pikosky, Matthew A.; Young, Andrew J.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Cloutier, Gregory J.; Fielding, Roger A.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708407005 ER PT J AU McClung, JP Karl, JP Bass, LJ Rood, JC Wiley, BC Cable, SJ Williams, KW Young, AJ AF McClung, James P. Karl, J. Philip Bass, Laura J. Rood, Jennifer C. Wiley, Bryan C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. TI Iron status declines in male Soldiers during military training despite increased dietary iron intake SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [McClung, James P.; Karl, J. Philip; Bass, Laura J.; Wiley, Bryan C.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Traning, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403349 ER PT J AU Meledeo, MA Bynum, JA Sondeen, JL Prince, MD Bowman, PD AF Meledeo, Michael Adam Bynum, James A. Sondeen, Jill L. Prince, M. Dale Bowman, Phillip D. TI Investigation of genes mediating the response of human endothelial cells to steady-state laminar flow SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Meledeo, Michael Adam; Bynum, James A.; Sondeen, Jill L.; Prince, M. Dale; Bowman, Phillip D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404105 ER PT J AU Meledeo, MA Campbell, JE Bowman, PD AF Meledeo, Michael Adam Campbell, James E. Bowman, Phillip D. TI Development of an in vitro model of the acute coagulopathy of trauma SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Meledeo, Michael Adam; Campbell, James E.; Bowman, Phillip D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403447 ER PT J AU Moore, NLT Johnson, CC Genovese, RF AF Moore, Nicole L. T. Johnson, Christina C. Genovese, Raymond F. TI Establishing baseline rat behavior in the elevated plus maze for detection of anxiogenic stimuli SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Moore, Nicole L. T.; Johnson, Christina C.; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403472 ER PT J AU Muhie, S Hammamieh, R Miller, SA Meyerhoff, J Carroll, E Jett, M AF Muhie, Seid Hammamieh, Rasha Miller, Stacy-ann Meyerhoff, James Carroll, Erica Jett, Marti TI Transcriptomic and Histopathologic Characterization of Mouse Model(s) Simulating Features of Post-Traumatic Stress Disorder SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Muhie, Seid; Hammamieh, Rasha; Miller, Stacy-ann; Meyerhoff, James; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [Carroll, Erica] USN, Med Res Ctr, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708402757 ER PT J AU Parsons, E Koros, J Obuya, C Aching, D Stewart, A AF Parsons, Emily Koros, Joseph Obuya, Clifford Aching, Doty Stewart, Ann TI Characterization of a Real-Time PCR Assay for the detection and quantitation of Plasmodium malariae parasitesd SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Parsons, Emily] Kalamazoo Coll, Kalamazoo, MI 49007 USA. [Koros, Joseph; Obuya, Clifford; Aching, Doty] USA, Med Res Kenya, Kisumu, Kenya. [Stewart, Ann] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708402779 ER PT J AU Pasiakos, SM McClung, HL Cloutier, GJ Andersen, NE Margolis, LM McClung, JP Pikosky, MA Fielding, RA Young, AJ AF Pasiakos, Stefan M. McClung, Holly L. Cloutier, Gregory J. Andersen, Nancy E. Margolis, Lee M. McClung, James P. Pikosky, Matthew A. Fielding, Roger A. Young, Andrew J. TI Leucine supplementation during endurance exercise enhances post-exercise muscle protein synthesis SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Pasiakos, Stefan M.; McClung, Holly L.; Andersen, Nancy E.; Margolis, Lee M.; McClung, James P.; Pikosky, Matthew A.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Cloutier, Gregory J.; Fielding, Roger A.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708401907 ER PT J AU Rastogi, A Bynum, J Stavchansky, S Bowman, PD AF Rastogi, Ashish Bynum, James Stavchansky, Salomon Bowman, Phillip D. TI Poor Correlation between In Vivo Imaging and Production of Light by Organs in Transgenic Mouse Engineered to Express Luciferase in Response to Hypoxia SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Rastogi, Ashish; Bynum, James; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX USA. [Rastogi, Ashish; Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708404354 ER PT J AU Rickards, CA Ryan, KL Hinojosa-Laborde, C Convertino, VA Lurie, KG AF Rickards, Caroline Alice Ryan, Kathy L. Hinojosa-Laborde, Carmen Convertino, Victor A. Lurie, Keith G. TI Cerebral blood velocity dynamics during inspiratory resistance breathing SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Rickards, Caroline Alice] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lurie, Keith G.] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN 55415 USA. [Lurie, Keith G.] Adv Circulatory Syst, Roseville, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708400267 ER PT J AU Rubal, BJ DeLorenzo, RA AF Rubal, Bernard J. DeLorenzo, Robert A. TI A cast-corrosion technique for assessing bone marrow vascularity for research and teaching using the intraosseous infusion of radiopaque silicone SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Rubal, Bernard J.; DeLorenzo, Robert A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708406243 ER PT J AU Ryan, KL Rickards, CA Hinojosa-Laborde, C Cooke, WH Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Cooke, William H. Convertino, Victor A. TI Muscle Sympathetic Nerve Activity (MSNA) at Presyncope: Influence of Tolerance to Central Hypovolemia SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403900 ER PT J AU Shear, DA Pedersen, R Davis, A Wei, G Chen, ZY Yao, CP Dave, J Lu, XCM Tortella, FC AF Shear, Deborah A. Pedersen, Rebecca Davis, Angela Wei, Guo Chen, Zhiyong Yao, Changping Dave, Jitendra Lu, Xi-Chun May Tortella, Frank C. TI Injury Severity Profile of Penetrating Ballistic-Like Brain Injury in Rats on Neurofunctional Outcome, Blood-Brain Barrier Permeability, and Brain Edema Formation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Shear, Deborah A.; Pedersen, Rebecca; Davis, Angela; Wei, Guo; Chen, Zhiyong; Yao, Changping; Dave, Jitendra; Lu, Xi-Chun May; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403920 ER PT J AU Smith, TJ Anderson, DJ Sikes, A Margolis, LM Young, AJ AF Smith, Tracey J. Anderson, Danielle J. Sikes, Anthony Margolis, Lee M. Young, Andrew J. TI Persistence of Lactobacillus Reuteri DSM17938 in the Human Intestinal Tract in Response to Different Storage Conditions SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting 2011 CY APR 09-13, 2011 CL Washington, DC SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET) C1 [Smith, Tracey J.; Margolis, Lee M.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Anderson, Danielle J.; Sikes, Anthony] Natick Soldier Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2011 VL 25 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IE UT WOS:000310708403072 ER EF