FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Williams, AA Orlicki, JA Escarsega, JA Labukas, J Placzankis, B AF Williams, Andre A. Orlicki, Joshua A. Escarsega, John A. Labukas, Joseph Placzankis, Brian TI Effects of sterics and electronics on metal binding of fluorescent molecules: Towards smart coating materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 242nd National Meeting of the American-Chemical-Society (ACS) CY AUG 28-SEP 01, 2011 CL Denver, CO SP Amer Chem Soc (ACS) C1 [Williams, Andre A.; Orlicki, Joshua A.; Escarsega, John A.; Labukas, Joseph; Placzankis, Brian] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM andre.arvin.williams@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 28 PY 2011 VL 242 MA 294-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 880BE UT WOS:000299378305187 ER PT J AU Zander, NE Orlicki, JA Rawlett, AM Beebe, TP AF Zander, Nicole E. Orlicki, Joshua A. Rawlett, Adam M. Beebe, Thomas P. TI Co-annular electrospun PAN-PMMA fibers: AFM and compositional characterization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 242nd National Meeting of the American-Chemical-Society (ACS) CY AUG 28-SEP 01, 2011 CL Denver, CO SP Amer Chem Soc (ACS) C1 [Zander, Nicole E.; Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Zander, Nicole E.; Beebe, Thomas P.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. EM nicole.zander@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 28 PY 2011 VL 242 MA 144-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 880BE UT WOS:000299378300500 ER PT J AU Del Favero, G Perez-Gomez, A Cabrera-Garcia, D Poli, M Tubaro, A Fernandez-Sanchez, TM Novelli, A AF Del Favero, G. Perez-Gomez, A. Cabrera-Garcia, D. Poli, M. Tubaro, A. Fernandez-Sanchez, T. M. Novelli, A. TI The palytoxin analogue 42-OH-PLTX mimics the effects of palytoxin in primary neuronal cultures SO TOXICOLOGY LETTERS LA English DT Meeting Abstract CT 47th Congress of the European-Societies-of-Toxicology CY AUG 28-31, 2011 CL Paris, FRANCE SP European Soc Toxicol C1 [Del Favero, G.] Univ Trieste, Trieste, Italy. [Perez-Gomez, A.; Cabrera-Garcia, D.; Fernandez-Sanchez, T. M.; Novelli, A.] Univ Oviedo, Univ Inst Biotechnol Asturias, Oviedo, Spain. [Poli, M.; Tubaro, A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RI Perez-Gomez, Anabel/B-1888-2015; Novelli, Antonello/P-7476-2015 OI Perez-Gomez, Anabel/0000-0001-9477-731X; Novelli, Antonello/0000-0002-0129-8350 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD AUG 28 PY 2011 VL 205 SU 1 BP S156 EP S156 DI 10.1016/j.toxlet.2011.05.549 PG 1 WC Toxicology SC Toxicology GA 806NI UT WOS:000293814500499 ER PT J AU Barnoy, S Baqar, S Kaminski, RW Collins, T Nemelka, K Hale, TL Ranallo, RT Venkatesan, MM AF Barnoy, S. Baqar, S. Kaminski, R. W. Collins, T. Nemelka, K. Hale, T. L. Ranallo, R. T. Venkatesan, M. M. TI Shigella sonnei vaccine candidates WRSs2 and WRSs3 are as immunogenic as WRSS1, a clinically tested vaccine candidate, in a primate model of infection SO VACCINE LA English DT Article DE Shigella sonnei; Live vaccine candidates; WRSs2; WRSs3 ID OUTER-MEMBRANE PROTEASE; FLEXNERI 2A; IMMUNE-RESPONSE; INTERCELLULAR SPREAD; ESCHERICHIA-COLI; RHESUS-MONKEYS; ORAL VACCINE; LIVE; SAFETY; INVASION AB Shigella causes diarrhea and dysentery through contaminated food and water. Shigella sonnei live vaccine candidates WRSs2 and WRSs3 are attenuated principally by the loss of VirG(IcsA) that prevents bacterial spread within the colonic epithelium. In this respect they are similar to the clinically tested vaccine candidate WRSS1. However, WRSs2 and WRSs3 are further attenuated by loss of senA, senB and WRSs3 also lacks msbB2. As previously shown in cell culture assays and in small animal models, these additional gene deletions reduced the levels of enterotoxicity and endotoxicity of WRSs2 and WRSs3, potentially making them safer than WRSS1. However the behavior of these second-generation VirG(IcsA)-based vaccine candidates in eliciting an immune response in a gastrointestinal model of infection has not been evaluated. In this study, WRSs2 and WRSs3 were nasogastrically administered to rhesus monkeys that were evaluated for colonization, as well as for systemic and mucosal immune responses. Both vaccine candidates were safe in rhesus monkeys and behaved comparably to WRSS1 in bacterial excretion rates that demonstrated robust intestinal colonization. Furthermore, humoral and mucosal immune responses elicited against bacterial antigens appeared similar in all categories across all three strains indicating that the additional gene deletions did not compromise the immunogenicity of these vaccine candidates. Based on data from previous clinical trials with WRSS1, it is likely that, WRSs2 and WRSs3 will not only be safer in human volunteers but will generate comparable levels of systemic and mucosal immune responses that were achieved with WRSS1. Published by Elsevier Ltd. C1 [Barnoy, S.; Kaminski, R. W.; Hale, T. L.; Ranallo, R. T.; Venkatesan, M. M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Baqar, S.] USN, Med Res Ctr, Infect Dis Directorate, Silver Spring, MD USA. [Collins, T.; Nemelka, K.] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM malabi.venkatesan@us.army.mil NR 58 TC 17 Z9 17 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 26 PY 2011 VL 29 IS 37 BP 6371 EP 6378 DI 10.1016/j.vaccine.2011.04.115 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 825AR UT WOS:000295243800030 PM 21596086 ER PT J AU Riley, MC Kirkup, BC Johnson, JD Lesho, EP Ockenhouse, CF AF Riley, Matthew C. Kirkup, Benjamin C., Jr. Johnson, Jake D. Lesho, Emil P. Ockenhouse, Christian F. TI Rapid whole genome optical mapping of Plasmodium falciparum SO MALARIA JOURNAL LA English DT Article ID MALARIA PARASITES; IMMUNE EVASION; SEQUENCE; DIVERSITY; OUTBREAK; ANTIGEN; VACCINE AB Background: Immune evasion and drug resistance in malaria have been linked to chromosomal recombination and gene copy number variation (CNV). These events are ideally studied using comparative genomic analyses; however in malaria these analyses are not as common or thorough as in other infectious diseases, partly due to the difficulty in sequencing and assembling complete genome drafts. Recently, whole genome optical mapping has gained wide use in support of genomic sequence assembly and comparison. Here, a rapid technique for producing whole genome optical maps of Plasmodium falciparum is described and the results of mapping four genomes are presented. Methods: Four laboratory strains of P. falciparum were analysed using the Argus (TM) optical mapping system to produce ordered restriction fragment maps of all 14 chromosomes in each genome. Plasmodium falciparum DNA was isolated directly from blood culture, visualized using the Argus (TM) system and assembled in a manner analogous to next generation sequence assembly into maps (AssemblyViewer (TM), OpGen Inc.(R)). Full coverage maps were generated for P. falciparum strains 3D7, FVO, D6 and C235. A reference P. falciparum in silico map was created by the digestion of the genomic sequence of P. falciparum with the restriction enzyme AflII, for comparisons to genomic optical maps. Maps were then compared using the MapSolver (TM) software. Results: Genomic variation was observed among the mapped strains, as well as between the map of the reference strain and the map derived from the putative sequence of that same strain. Duplications, deletions, insertions, inversions and misassemblies of sizes ranging from 3,500 base pairs up to 78,000 base pairs were observed. Many genomic events occurred in areas of known repetitive sequence or high copy number genes, including var gene clusters and rifin complexes. Conclusions: This technique for optical mapping of multiple malaria genomes allows for whole genome comparison of multiple strains and can assist in identifying genetic variation and sequence contig assembly. New protocols and technology allowed us to produce high quality contigs spanning four P. falciparum genomes in six weeks for less than $1,000.00 per genome. This relatively low cost and quick turnaround makes the technique valuable compared to other genomic sequencing technologies for studying genetic variation in malaria. C1 [Riley, Matthew C.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Kirkup, Benjamin C., Jr.; Lesho, Emil P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Johnson, Jake D.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Kirkup, Benjamin C., Jr.; Lesho, Emil P.] Uniformed Serv Univ Hlth Sci, Silver Spring, MD USA. RP Riley, MC (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. EM matthew.curtis.riley@us.army.mil RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 NR 27 TC 11 Z9 11 U1 1 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 26 PY 2011 VL 10 AR 252 DI 10.1186/1475-2875-10-252 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 819RS UT WOS:000294848000001 PM 21871093 ER PT J AU Sutcliffe, S Nevin, RL Pakpahan, R Elliott, DJ Cole, SR De Marzo, AM Gaydos, CA Isaacs, WB Nelson, WG Sokoll, LJ Zenilman, JM Cersovsky, SB Platz, EA AF Sutcliffe, S. Nevin, R. L. Pakpahan, R. Elliott, D. J. Cole, S. R. De Marzo, A. M. Gaydos, C. A. Isaacs, W. B. Nelson, W. G. Sokoll, L. J. Zenilman, J. M. Cersovsky, S. B. Platz, E. A. TI Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration SO BRITISH JOURNAL OF CANCER LA English DT Article DE sexually transmitted infections; chlamydia; gonorrhoea; non-chlamydial, non-gonococcal urethritis; prostate-specific antigen; prostate cancer ID SERUM; CANCER AB BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. RESULTS: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (>= 40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively). CONCLUSION: Chlamydia and gonorrhoea may infect the prostate of some infected men. British Journal of Cancer (2011) 105, 602-605. doi:10.1038/bjc.2011.271 www.bjcancer.com Published online 26 July 2011 (C) 2011 Cancer Research UK C1 [Sutcliffe, S.; Pakpahan, R.] Washington Univ, Sch Med, Div Publ Hlth Sci, Dept Surg, St Louis, MO 63110 USA. [Sutcliffe, S.] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, Dept Surg, St Louis, MO 63110 USA. [Nevin, R. L.] Bayne Jones Army Community Hosp, Dept Prevent Med, Fort Polk, LA 71459 USA. [Cole, S. R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA. [De Marzo, A. M.] Johns Hopkins Med Inst, Dept Pathol, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. [De Marzo, A. M.] Johns Hopkins Med Inst, Dept Oncol, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. [De Marzo, A. M.; Isaacs, W. B.; Platz, E. A.] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA. [Gaydos, C. A.] Johns Hopkins Med Inst, Div Infect Dis, Dept Med, Baltimore, MD 21205 USA. [Nelson, W. G.] Johns Hopkins Med Inst, Dept Oncol, James Buchanan Brady Urol Inst, Baltimore, MD 21231 USA. [Nelson, W. G.] Johns Hopkins Med Inst, Dept Pathol, James Buchanan Brady Urol Inst, Baltimore, MD 21231 USA. [Nelson, W. G.] Johns Hopkins Med Inst, Dept Pharmacol, James Buchanan Brady Urol Inst, Baltimore, MD 21231 USA. [Sokoll, L. J.] Johns Hopkins Med Inst, Dept Pathol, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA. [Sokoll, L. J.] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA. [Zenilman, J. M.] Johns Hopkins Med Inst, Div Infect Dis, Dept Med, Baltimore, MD 21224 USA. [Cersovsky, S. B.] USA, Inst Publ Hlth, Publ Hlth Command Provis, Aberdeen, MD 21010 USA. [Platz, E. A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. RP Sutcliffe, S (reprint author), Washington Univ, Sch Med, Div Publ Hlth Sci, Dept Surg, 660 S Euclid Ave,Box 8100,Room 5026, St Louis, MO 63110 USA. EM sutcliffes@wudosis.wustl.edu OI Sutcliffe, Siobhan/0000-0002-4613-8107; Nevin, Remington/0000-0002-0534-1889 FU Patrick C Walsh Prostate Cancer Research Fund FX This study was funded by the Patrick C Walsh Prostate Cancer Research Fund. We thank Dr Angelia A Eick and Zheng Hu at the Armed Forces Health Surveillance Center for help with participant selection, and Dr Catherine G Sutcliffe for help in preparing serum specimens for testing and coordinating PSA testing. Information in this manuscript was presented at the Annual American Urological Association Meeting in Chicago, IL, in April 2009 (abstract 175). NR 16 TC 3 Z9 3 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD AUG 23 PY 2011 VL 105 IS 5 BP 602 EP 605 DI 10.1038/bjc.2011.271 PG 4 WC Oncology SC Oncology GA 811KG UT WOS:000294207800003 PM 21792196 ER PT J AU Cheng, SJ Beyer, FL Mather, BD Moore, RB Long, TE AF Cheng, Shijing Beyer, Frederick L. Mather, Brian D. Moore, Robert B. Long, Timothy E. TI Phosphonium-Containing ABA Triblock Copolymers: Controlled Free Radical Polymerization of Phosphonium Ionic Liquids SO MACROMOLECULES LA English DT Article ID SULFONATED POLYSTYRENE IONOMERS; BLOCK-COPOLYMERS; N-ISOPROPYLACRYLAMIDE; POLYMERS; MORPHOLOGY; AMMONIUM; SALTS; RAFT; TRANSPORT; MEMBRANES AB Phosphonium ion-containing acrylate triblock (ABA) copolymers were synthesized using nitroxide mediated radical polymerization. The polymerization of styrenic phosphonium-containing ionic liquid monomers using a difunctional alkoxyamine initiator, DEPN(2), afforded an ABA triblock copolymer with an n-butyl acrylate soft center block (DP similar to 400) and symmetric phosphonium-containing external reinforcing blocks (DP < 30). Two phosphonium monomers with different alkyl substituent lengths enabled an investigation of the effects of ionic aggregation of phosphonium cations on the physical properties of ABA block copolymer ionomers. Subsequently, the thermomechanical properties and morphologies of these materials were compared to a noncharged triblock copolymer analogue with neutral polystyrene external blocks. Shortening the alkyl substituents on the phosphonium cation enhanced the hydrophilicity of tributyl-4-vinylbenzyl phosphonium chloride (BPCl) relative to trioctyl-4-vinylbenzyl phosphonium chloride (OPCl). In both cases, phosphonium cations promoted microphase-separation and thermoplastic elastomer performance for the OPCl- and BPCl-containing triblock copolymers compared to a less well-defined, microphase segregated morphology for the styrene analogue. Dynamic mechanical analysis (DMA) of phosphonium-containing triblock copolymers exhibited well-defined rubbery plateau regions, whereas the plateau was shortened for the nonionic analogue. The solid state morphologies of the block copolymers were studied using small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM), and both techniques revealed phase separation at the nanoscale. DMA studies indicated that phosphonium aggregation governed flow activation energies. C1 [Cheng, Shijing; Mather, Brian D.; Moore, Robert B.; Long, Timothy E.] Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Long, TE (reprint author), Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. EM telong@vt.edu RI Moore, Robert/E-9619-2011; Paquette, Joseph/O-4271-2015 OI Moore, Robert/0000-0001-9057-7695; Paquette, Joseph/0000-0001-6023-5125 FU American Chemical Society; NSF [CHE-0722638]; U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-07-1-0452]; Ionic Liquids in Electro-Active Devices Multidisciplinary University Research Initiative (ILEAD MURI) FX The authors acknowledge the American Chemical Society Petroleum Research Fund for partial support of this research. Aspects of this work were carried out using instruments in the Nanoscale Characterization and Fabrication Laboratory, a Virginia Tech facility operated by the Institute for Critical Technology and Applied Science (ICTAS). The authors particularly thank Steve McCartney and John McIntosh at ICTAS for their help with TEM imaging. We also acknowledge funding from NSF (CHE-0722638) for the acquisition of our Agilent 6220 LC-TOF-MS. Additionally, this research was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract/Grant Number W911NF-07-1-0452, Ionic Liquids in Electro-Active Devices Multidisciplinary University Research Initiative (ILEAD MURI). NR 46 TC 54 Z9 55 U1 4 U2 74 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD AUG 23 PY 2011 VL 44 IS 16 BP 6509 EP 6517 DI 10.1021/ma200829h PG 9 WC Polymer Science SC Polymer Science GA 809SF UT WOS:000294076300034 ER PT J AU Oballah, P Flach, B Eller, LA Eller, MA Ouma, B de Souza, M Kibuuka, HN Wabwire-Mangen, F Brown, BK Michael, NL Robb, ML Montefiori, D Polonis, VR AF Oballah, Peter Flach, Britta Eller, Leigh A. Eller, Michael A. Ouma, Benson de Souza, Mark Kibuuka, Hannah N. Wabwire-Mangen, Fred Brown, Bruce K. Michael, Nelson L. Robb, Merlin L. Montefiori, David Polonis, Victoria R. TI B Cell Depletion in HIV-1 Subtype A Infected Ugandan Adults: Relationship to CD4 T Cell Count, Viral Load and Humoral Immune Responses SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODY-RESPONSES; DISEASE PROGRESSION; MEDIATED CYTOTOXICITY; RHESUS MACAQUES; LYMPHOCYTE DYSFUNCTIONS; ANTIRETROVIRAL THERAPY; EFFECTOR FUNCTION; DIFFERENT RATES; MEMORY AB To better understand the nature of B cell dysfunctions in subjects infected with HIV-1 subtype A, a rural cohort of 50 treatment-naive Ugandan patients chronically infected with HIV-1 subtype A was studied, and the relationship between B cell depletion and HIV disease was assessed. B cell absolute counts were found to be significantly lower in HIV-1+ patients, when compared to community matched negative controls (p<0.0001). HIV-1-infected patients displayed variable functional and binding antibody titers that showed no correlation with viral load or CD4+ T cell count. However, B cell absolute counts were found to correlate inversely with neutralizing antibody (NAb) titers against subtype A (p = 0.05) and subtype CRF02_AG (p = 0.02) viruses. A positive correlation was observed between subtype A gp120 binding antibody titers and NAb breadth (p = 0.02) and mean titer against the 10 viruses (p = 0.0002). In addition, HIV-1 subtype A sera showed preferential neutralization of the 5 subtype A or CRF02_AG pseudoviruses, as compared with 5 pseudoviruses from subtypes B, C or D (p<0.001). These data demonstrate that in patients with chronic HIV-1 subtype A infection, significant B cell depletion can be observed, the degree of which does not appear to be associated with a decrease in functional antibodies. These findings also highlight the potential importance of subtype in the specificity of cross-clade neutralization in HIV-1 infection. C1 [Oballah, Peter; Flach, Britta; Ouma, Benson; Kibuuka, Hannah N.; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Flach, Britta; Eller, Leigh A.; Eller, Michael A.; de Souza, Mark; Brown, Bruce K.; Michael, Nelson L.; Robb, Merlin L.; Polonis, Victoria R.] Mil HIV Res Program, Rockville, MD USA. [Flach, Britta; Eller, Leigh A.; Eller, Michael A.; de Souza, Mark; Brown, Bruce K.; Robb, Merlin L.] Henry M Jackson Fdn, Rockville, MD USA. [de Souza, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Michael, Nelson L.; Polonis, Victoria R.] Walter Reed Army Inst Res, Rockville, MD USA. [Montefiori, David] Duke Univ, Durham, NC USA. RP Oballah, P (reprint author), Makerere Univ, Walter Reed Project, Kampala, Uganda. EM vpolonis@hivresearch.org FU Bill and Melinda Gates Foundation through Duke University [210810/2] FX The funding for this study was provided by the Bill and Melinda Gates Foundation through Duke University to Makere University (contract number 210810/2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 83 TC 3 Z9 3 U1 2 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 23 PY 2011 VL 6 IS 8 AR e22653 DI 10.1371/journal.pone.0022653 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 811YA UT WOS:000294253500002 PM 21886768 ER PT J AU Bittel, BC Lenahan, PM Ryan, JT Fronheiser, J Lelis, AJ AF Bittel, B. C. Lenahan, P. M. Ryan, J. T. Fronheiser, J. Lelis, A. J. TI Spin dependent charge pumping in SiC metal-oxide-semiconductor field-effect-transistors SO APPLIED PHYSICS LETTERS LA English DT Article ID RECOMBINATION; DEFECTS; INTERFACE AB We demonstrate a very powerful electrically detected magnetic resonance (EDMR) technique, spin dependent charge pumping (SDCP) and apply it to 4H SiC metal-oxide-semiconductor field-effect-transistors. SDCP combines a widely used electrical characterization tool with the most powerful analytical technique for providing atomic scale structure of point defects in electronic materials. SDCP offers a large improvement in sensitivity over the previously established EDMR technique called spin dependent recombination, offering higher sensitivity and accessing a wider energy range within the bandgap. (C) 2011 American Institute of Physics. [doi:10.1063/1.3630024] C1 [Bittel, B. C.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA. [Ryan, J. T.] NIST, Div Semicond Elect, Gaithersburg, MD 20899 USA. [Fronheiser, J.] GE Global Res, Niskayuna, NY 12309 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Bittel, BC (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM bcb183@psu.edu FU U.S. Department of Commerce [NIST 60NANB10D109]; US Army Research Laboratory FX We wish to thank Thomas Aichinger for assistance in setting up the electrical measurement apparatus. The work at Penn State supported by the U.S. Department of Commerce under Award No. NIST 60NANB10D109 and the US Army Research Laboratory. Any opinions, findings, conclusions, or other recommendations expressed herein are those of the authors and do not necessarily reflect the views of the U.S. Commerce Department or the US Army Research Laboratory. NR 17 TC 8 Z9 8 U1 0 U2 15 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 22 PY 2011 VL 99 IS 8 AR 083504 DI 10.1063/1.3630024 PG 3 WC Physics, Applied SC Physics GA 813ID UT WOS:000294359100084 ER PT J AU Brown, JE McBride, CS Johnson, P Ritchie, S Paupy, C Bossin, H Lutomiah, J Fernandez-Salas, I Ponlawat, A Cornel, AJ Black, WC Gorrochotegui-Escalante, N Urdaneta-Marquez, L Sylla, M Slotman, M Murray, KO Walker, C Powell, JR AF Brown, Julia E. McBride, Carolyn S. Johnson, Petrina Ritchie, Scott Paupy, Christophe Bossin, Herve Lutomiah, Joel Fernandez-Salas, Ildefonso Ponlawat, Alongkot Cornel, Anthony J. Black, William C. Gorrochotegui-Escalante, Norma Urdaneta-Marquez, Ludmel Sylla, Massamba Slotman, Michel Murray, Kristy O. Walker, Christopher Powell, Jeffrey R. TI Worldwide patterns of genetic differentiation imply multiple 'domestications' of Aedes aegypti, a major vector of human diseases SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article DE Aedes aegypti aegypti; Aedes aegypti formosus; human habitats; microsatellites; evolution; mosquito genetics ID YELLOW-FEVER MOSQUITO; L DIPTERA-CULICIDAE; POPULATION-STRUCTURE; HUMAN COMMENSAL; DNA VARIATION; DENGUE; SENEGAL; VIRUS; SOFTWARE; AFRICA AB Understanding the processes by which species colonize and adapt to human habitats is particularly important in the case of disease-vectoring arthropods. The mosquito species Aedes aegypti, a major vector of dengue and yellow fever viruses, probably originated as a wild, zoophilic species in sub-Saharan Africa, where some populations still breed in tree holes in forested habitats. Many populations of the species, however, have evolved to thrive in human habitats and to bite humans. This includes some populations within Africa as well as almost all those outside Africa. It is not clear whether all domestic populations are genetically related and represent a single 'domestication' event, or whether association with human habitats has developed multiple times independently within the species. To test the hypotheses above, we screened 24 worldwide population samples of Ae. aegypti at 12 polymorphic microsatellite loci. We identified two distinct genetic clusters: one included all domestic populations outside of Africa and the other included both domestic and forest populations within Africa. This suggests that human association in Africa occurred independently from that in domestic populations across the rest of the world. Additionally, measures of genetic diversity support Ae. aegypti in Africa as the ancestral form of the species. Individuals from domestic populations outside Africa can reliably be assigned back to their population of origin, which will help determine the origins of new introductions of Ae. aegypti. C1 [Brown, Julia E.; Powell, Jeffrey R.] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA. [McBride, Carolyn S.] Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA. [Johnson, Petrina; Ritchie, Scott] James Cook Univ, Sch Publ Hlth Trop Med & Rehabil Sci, Cairns, Qld 4870, Australia. [Paupy, Christophe] IRD, UR016, F-34394 Montpellier, France. [Bossin, Herve] Inst Louis Malarde, Med Entomol Lab, Papeete 98713, Fr Polynesia. [Lutomiah, Joel] Kenya Govt Med Res Ctr, Ctr Virus Res, Arbovirol Hemorrhag Fevers Lab, Nairobi, Kenya. [Fernandez-Salas, Ildefonso] Univ Autonoma Nuevo Leon, Fac Ciencias Biol, Lab Entomol Med, San Nicolas De Los Garza 66450, Nuevo Leon, Mexico. [Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Vector Biol & Control Sect, Bangkok 10400, Thailand. [Cornel, Anthony J.] Univ Calif Davis, Dept Entomol, Mosquito Control Res Lab, Parlier, CA 93648 USA. [Black, William C.; Gorrochotegui-Escalante, Norma; Urdaneta-Marquez, Ludmel; Sylla, Massamba] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Slotman, Michel] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. [Murray, Kristy O.; Walker, Christopher] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Ctr Infect Dis, Houston, TX 77030 USA. RP Brown, JE (reprint author), Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA. EM julia.brown@yale.edu OI BOSSIN, Herve/0000-0002-3655-0923; Paupy, Christophe/0000-0002-7122-2079 FU NIH [T32-GM07499-33, R01AI083368, RO1 AI046018]; Yale Institute for Biospheric Studies (YIBS), Center for Field Ecology; Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative; United States Department of Defense, Telemedicine and Advanced Technology Research Center [W81XWH-07-2-0031]; YIBS FX We thank Greg Lanzaro, Durland Fish, Charles Jeannin, Tuterarii Paoaafaite, Henri Frogier, Barry J. Beaty, Gustavo Ponce Garcia, Adriana E. Flores, Larry Hribar, Rosemary Sang, Barry Miller and John-Paul Mutebi for their help in collecting samples, Walter Tabachnick and Leslie Vosshall for their comments on the manuscript, and Jennifer Simpson, Janelle Winters and Vanessa Obas for their efforts in the laboratory. J. E. B. was supported by NIH Pre-doctoral Training in Genetics (T32-GM07499-33) and the Yale Institute for Biospheric Studies (YIBS), Center for Field Ecology pilot grant. Senegal collections were supported by NIH R01AI083368 to M.Sy. and W. C. B. Collections in Rabai, Kenya, were partly supported by a grant to Richard Axel and Leslie Vosshall from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative, and by an investigator award to Leslie Vosshall from the Howard Hughes Medical Institute. C. W. and collections in Texas, USA, were supported by a grant from the United States Department of Defense, Telemedicine and Advanced Technology Research Center (TexSHIELD W81XWH-07-2-0031) to K.O.M. Development of molecular markers was supported by YIBS. The rest of the study was supported by NIH RO1 AI046018 (J.R.P.). NR 68 TC 63 Z9 64 U1 6 U2 47 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P ROY SOC B-BIOL SCI JI Proc. R. Soc. B-Biol. Sci. PD AUG 22 PY 2011 VL 278 IS 1717 BP 2446 EP 2454 DI 10.1098/rspb.2010.2469 PG 9 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA 790ML UT WOS:000292592000006 PM 21227970 ER PT J AU Katz, A Sankaran, V AF Katz, Aaron Sankaran, Venkateswaran TI Mesh quality effects on the accuracy of CFD solutions on unstructured meshes SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Unstructured grids; Mesh quality; Manufactured solutions; Error convergence; High-order methods ID VERIFICATION; DYNAMICS; SCHEMES; GRIDS; CODE AB The order of accuracy and error magnitude of node- and cell-centered schemes are examined on representative unstructured meshes and flowfield solutions for computation fluid dynamics. Specifically, we investigate the properties of inviscid and viscous flu), cretizations for isotropic and highly stretched meshes using the Method of Manufacture Solutions. Grid quality effects are studied by randomly perturbing the base meshes ant aloguing the error convergence as a function of grid size. For isotropic grids, node-ceni approaches produce less error than cell-centered approaches. Moreover, a corrected r centered scheme is shown to maintain third order accuracy for the inviscid terms on trary triangular meshes. In contrast, for stretched meshes, cell-centered scheme favored, with cell-centered prismatic approaches in particular showing the lowest of error. In three dimensions, simple flux integrations on non-planar control volume lead to first-order solution errors, while second-order accuracy is recovered by trian: tion of the non-planar faces. (C) 2011 Elsevier Inc. All rights reserve. C1 [Katz, Aaron; Sankaran, Venkateswaran] USA, Aeroffightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. RP Katz, A (reprint author), NASA, Ames Res Ctr, M-S 215-1, Moffett Field, CA 94035 USA. EM akatz@merlin.arc.nasa.gov RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 FU Department of Defense High Performance Computing Modernization Office (HPCMO); US Department of Defense HPC Modernization Program Office FX Development was performed at the HPC Institute for Advanced Rotorcraft Modeling and Simulation (HIARMS) located at the US Army Aeroflightdynamics Directorate at Moffett Field, CA, which is supported by the Department of Defense High Performance Computing Modernization Office (HPCMO). Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the US Department of Defense HPC Modernization Program Office. NR 27 TC 22 Z9 23 U1 0 U2 10 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD AUG 20 PY 2011 VL 230 IS 20 BP 7670 EP 7686 DI 10.1016/j.jcp.2011.06.023 PG 17 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 815HY UT WOS:000294517900007 ER PT J AU Kumar, S Zhang, MJ Li, PG Dispenzieri, A Milone, GA Lonial, S Krishnan, A Maiolino, A Wirk, B Weiss, B Freytes, CO Vogl, DT Vesole, DH Lazarus, HM Meehan, KR Hamadani, M Lill, M Callander, NS Majhail, NS Wiernik, PH Nath, R Kamble, RT Vij, R Kyle, RA Gale, RP Hari, PN AF Kumar, Shaji Zhang, Mei-Jie Li, Peigang Dispenzieri, Angela Milone, Gustavo A. Lonial, Sagar Krishnan, Amrita Maiolino, Angelo Wirk, Baldeep Weiss, Brendan Freytes, Cesar O. Vogl, Dan T. Vesole, David H. Lazarus, Hillard M. Meehan, Kenneth R. Hamadani, Mehdi Lill, Michael Callander, Natalie S. Majhail, Navneet S. Wiernik, Peter H. Nath, Rajneesh Kamble, Rammurti T. Vij, Ravi Kyle, Robert A. Gale, Robert Peter Hari, Parameswaran N. TI Trends in allogeneic stem cell transplantation for multiple myeloma: a CIBMTR analysis SO BLOOD LA English DT Article ID BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; MOLECULAR REMISSION; PERIPHERAL-BLOOD; HIGH-RISK; AUTOLOGOUS TRANSPLANTATION; PROGNOSTIC-FACTORS; EUROPEAN GROUP; SURVIVAL; THERAPY AB Allogeneic hematopoietic cell transplantation in multiple myeloma is limited by prior reports of high treatment-related mortality. We analyzed outcomes after allogeneic hematopoietic cell transplantation for multiple myeloma in 1207 recipients in 3 cohorts based on the year of transplantation: 1989-1994 (n = 343), 1995-2000 (n = 376), and 2001-2005 (n = 488). The most recent cohort was significantly older (53% > 50 years) and had more recipients after prior autotransplantation. Use of unrelated donors, reduced-intensity conditioning and the blood cell grafts increased over time. Rates of acute graft-versus-host (GVHD) were similar, but chronic GVHD rates were highest in the most recent cohort. Overall survival (OS) at 1-year increased over time, reflecting a decrease in treatment-related mortality, but 5-year relapse rates increased from 39% (95% confidence interval [CI], 33%-44%) in 1989-1994 to 58% (95% CI, 51%-64%; P < .001) in the 20012005 cohort. Projected 5-year progression-free survival and OS are 14% (95% CI, 9%-20%) and 29% (95% CI, 23%-35%), respectively, in the latest cohort. Increasing age, longer interval from diagnosis to transplantation, and unrelated donor grafts adversely affected OS in multivariate analysis. Survival at 5 years for subjects with none, 1, 2, or 3 of these risk factors were 41% (range, 36%-47%), 32% (range, 27%-37%), 25% (range, 19%31%), and 3% (range, 0%-11%), respectively (P < .0001). (Blood. 2011;118(7):1979-1988) C1 [Zhang, Mei-Jie; Li, Peigang; Hari, Parameswaran N.] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplantat Res, Milwaukee, WI 53226 USA. [Kumar, Shaji; Dispenzieri, Angela; Kyle, Robert A.] Mayo Clin, Div Hematol & Internal Med, Rochester, MN USA. [Milone, Gustavo A.] Fundaleu, Buenos Aires, DF, Argentina. [Lonial, Sagar] Emory Univ Hosp, Div Hematol & Oncol, Atlanta, GA 30322 USA. [Krishnan, Amrita] City Hope Natl Med Ctr, Dept Hematol Oncol, Duarte, CA 91010 USA. [Maiolino, Angelo] Hosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil. [Wirk, Baldeep] Shands HealthCare, Gainesville, FL USA. [Wirk, Baldeep] Univ Florida, Gainesville, FL USA. [Weiss, Brendan] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Freytes, Cesar O.] UTHSC Vet Hlth Care Syst, San Antonio, TX USA. [Vogl, Dan T.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Vesole, David H.] Hackensack Univ, Med Ctr, Hackensack, NJ USA. [Lazarus, Hillard M.] Univ Hosp Case Med Ctr, Cleveland, OH USA. [Meehan, Kenneth R.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Hamadani, Mehdi] W Virginia Univ Hosp Inc, Morgantown, WV USA. [Lill, Michael] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Callander, Natalie S.] Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA. [Majhail, Navneet S.] Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA. [Wiernik, Peter H.] St Lukes Roosevelt Hosp, Continuum Canc Ctr, New York, NY USA. [Nath, Rajneesh] UMass Mem Med Ctr, Worcester, MA USA. [Kamble, Rammurti T.] Baylor Coll Med Ctr Cell & Gene Therapy, Houston, TX USA. [Vij, Ravi] Barnes Jewish Hosp, St Louis, MO 63110 USA. [Gale, Robert Peter] Celgene Corp, Summit, NJ USA. RP Hari, PN (reprint author), Med Coll Wisconsin, Ctr Int Blood & Marrow Transplantat Res, 9200 W Wisconsin Ave,Ste C5500, Milwaukee, WI 53226 USA. EM phari@mcw.edu RI Kumar, Shaji/A-9853-2008; OI Kumar, Shaji/0000-0001-5392-9284; Vogl, Dan/0000-0002-2935-2566; Hamadani, Mehdi/0000-0001-5372-510X; Hari, Parameswaran/0000-0002-8800-297X; Dispenzieri, Angela/0000-0001-8780-9512 FU National Cancer Institute (NCI) [U24-CA76518, 5U01HL069294]; National Heart, Lung, and Blood Institute (NHLBI); National Institute of Allergy and Infectious Diseases (NIAID); Health Resources and Services Administration (HRSA/DHHS) [HHSH234200637015C]; Office of Naval Research [N00014-06-1-0704, N00014-08-1-0058]; AABB; Allos Inc; Astellas Pharma US Inc; Be the Match Foundation; Biogen IDEC; Bio-Marin Pharmaceutical Inc; Biovitrum AB; BloodCenter of Wisconsin; Blue Cross and Blue Shield Association; Bone Marrow Foundation; Buchanan Family Foundation; CaridianBCT; Celgene Corporation; CellGenix GmbH; Children's Leukemia Research Association; ClinImmune Labs; CTI Clinical Trial and Consulting Services; Eisai Inc; Genentech Inc; Genzyme Corporation; Histogenetics Inc; HKS Medical Information Systems; Hospira Inc.; Kirin Brewery Co Ltd; Leukemia & Lymphoma Society; Merck Company; Medical College of Wisconsin; Millennium Pharmaceuticals Inc; Miller Pharmacal Group; Milliman USA Inc; Miltenyi Biotec Inc; National Marrow Donor Program; Nature Publishing Group; Novartis Oncology; Oncology Nursing Society; Osiris Therapeutics Inc; Otsuka America Pharmaceutical Inc; Pall Life Sciences; Pfizer Inc; Schering Corporation; Sigma-Tau Pharmaceuticals; Soligenix Inc; StemCyte Inc; StemSoft Software Inc; Sysmex America Inc; THERAKOS Inc; Vidacare Corporation; ViraCor Laboratories; ViroPharma Inc; Wellpoint Inc. FX The CIBMTR is supported by the Public Health Service (grant/cooperative agreement U24-CA76518) from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID); NHLBI and NCI (grant/cooperative agreement 5U01HL069294); Health Resources and Services Administration (HRSA/DHHS; contract HHSH234200637015C); the Office of Naval Research (grants N00014-06-1-0704 and N00014-08-1-0058); and by grants from AABB; Allos Inc; Amgen Inc; anonymous donation to the Medical College of Wisconsin; Astellas Pharma US Inc; Be the Match Foundation; Biogen IDEC; Bio-Marin Pharmaceutical Inc; Biovitrum AB; BloodCenter of Wisconsin; Blue Cross and Blue Shield Association; Bone Marrow Foundation; Buchanan Family Foundation; CaridianBCT; Celgene Corporation; CellGenix GmbH; Children's Leukemia Research Association; ClinImmune Labs; CTI Clinical Trial and Consulting Services; Eisai Inc; Genentech Inc; Genzyme Corporation; Histogenetics Inc; HKS Medical Information Systems; Hospira Inc.; Kirin Brewery Co Ltd; The Leukemia & Lymphoma Society; Merck & Company; The Medical College of Wisconsin; Millennium Pharmaceuticals Inc; Miller Pharmacal Group; Milliman USA Inc; Miltenyi Biotec Inc; National Marrow Donor Program; Nature Publishing Group; Novartis Oncology; Oncology Nursing Society; Osiris Therapeutics Inc; Otsuka America Pharmaceutical Inc; Pall Life Sciences; Pfizer Inc; Schering Corporation; Sigma-Tau Pharmaceuticals; Soligenix Inc; StemCyte Inc; StemSoft Software Inc; Sysmex America Inc; THERAKOS Inc; Vidacare Corporation; ViraCor Laboratories; ViroPharma Inc; and Wellpoint Inc. NR 34 TC 30 Z9 32 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD AUG 18 PY 2011 VL 118 IS 7 BP 1979 EP 1988 DI 10.1182/blood-2011-02-337329 PG 10 WC Hematology SC Hematology GA 808WC UT WOS:000294011500038 PM 21690560 ER PT J AU Guzman-Cornejo, C Robbins, RG Guglielmone, AA Montiel-Parra, G Perez, TM AF Guzman-Cornejo, Carmen Robbins, Richard G. Guglielmone, Alberto A. Montiel-Parra, Griselda Maria Perez, Tila TI The Amblyomma (Acari: Ixodida: Ixodidae) of Mexico: Identification Keys, Distribution and Hosts SO ZOOTAXA LA English DT Article DE Amblyomma; Ixodidae; keys; distribution; hosts; Mexico ID UNITED-STATES; TICKS; CAJENNENSE; RECORDS; ARGASIDAE; PARASITES; REPTILES; MAMMALS; 1ST AB Taxonomic keys, distributional data and hosts are provided for the 26 Amblyomma species known from Mexico. Members of this genus have been collected in 30 of Mexico's 32 states and are associated with 43 nominal vertebrate taxa, of which 40 have been identified to species and four (Python sp., Myrmecophaga tridactyla, Tamandua tetradactyla, Tupinambis teguixin) are non-native. Mammals are the principal class of vertebrates parasitized by Mexican Amblyomma species, followed by reptiles, birds and amphibians. Our knowledge of Mexican Amblyomma is still far from complete because many potential hosts have not yet been examined and vast areas of the country remain unexplored. C1 [Guzman-Cornejo, Carmen] Univ Nacl Autonoma Mexico, Lab Acarol, Fac Ciencias, Dept Biol Comparada, Mexico City 04510, DF, Mexico. [Robbins, Richard G.] Walter Reed Army Med Ctr, ISD AFPMB, Washington, DC 20307 USA. [Guglielmone, Alberto A.] Inst Nacl Tecnol Agropecuaria, RA-2300 Rafaela, Santa Fe, Argentina. [Montiel-Parra, Griselda; Maria Perez, Tila] Univ Nacl Autonoma Mexico, Dept Zool, Inst Biol, Coyoacan 04510, DF, Mexico. RP Guzman-Cornejo, C (reprint author), Univ Nacl Autonoma Mexico, Lab Acarol, Fac Ciencias, Dept Biol Comparada, Ciudad Univ, Mexico City 04510, DF, Mexico. EM mcgc@fciencias.unam.mx NR 85 TC 14 Z9 14 U1 1 U2 4 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD AUG 18 PY 2011 IS 2998 BP 16 EP 38 PG 23 WC Zoology SC Zoology GA 807ZP UT WOS:000293942400002 ER PT J AU Dmitriev, AE Castner, S Lehman, RA Ling, GSF Symes, AJ AF Dmitriev, Anton E. Castner, Suzanne Lehman, Ronald A., Jr. Ling, Geoffrey S. F. Symes, Aviva J. TI Alterations in Recovery from Spinal Cord Injury in Rats Treated with Recombinant Human Bone Morphogenetic Protein-2 for Posterolateral Arthrodesis SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID CENTRAL NEUROPATHIC PAIN; LUMBAR INTERBODY FUSION; ANTERIOR CERVICAL-SPINE; FUNCTIONAL RECOVERY; OVERGROUND LOCOMOTION; AXONAL GROWTH; IN-VIVO; ACTIVATION; INFLAMMATION; REGENERATION AB Background: Treatment of trauma-related spinal instability with use of recombinant human bone morphogenetic protein-2 (rhBMP-2) may appear as a viable option, but little is known of the direct effects of rhBMP-2 on the injured spinal cord. In the current study, we investigated the acute and long-term effects of using rhBMP-2 in the posterolateral spine at the level of a spinal cord injury in rats. Methods: Fifty-two rats underwent a T10 dorsal hemisection and were assigned to one of two groups: the vehicle control group (twenty-four rats) or the rhBMP-2 group (twenty-four rats). Within each group, animals were further subdivided according to the follow-up period: one week and six weeks after the lesion. For the acute phase, an additional group of four rats received recombinant human albumin, to account for the cross-species inflammatory response. Postoperatively, locomotor function was assessed on a weekly basis with use of an open field scale and digital footprint analysis. After the animals were killed, they were perfused and the spinal cords analyzed for inflammatory markers, gliosis, and extracellular matrix proteins with use of immunohistochemistry. Results: At one week, there was a significant increase in reactive astrocyte, macrophage-microglia, and fibroblast immunoreactivity around the lesion in the rhBMP-2-treated rats relative to controls. Additionally, there was increased staining for chondroitin sulfate proteoglycans. Similar intergroup morphologic differences persisted at six weeks. Functionally, in the acute phase, rhBMP-2-treated animals demonstrated more open field and fine motor control deficits relative to the controls. By six weeks, both groups had equivalent functional scores, but those treated with rhBMP-2 retained significantly greater paw angle changes than the control animals. Conclusions: Our findings indicate that in a rat model, rhBMP-2 use in the vicinity of a penetrating spinal cord injury triggers detrimental changes in the morphology of the spinal cord lesion and alters functional recovery. C1 [Dmitriev, Anton E.; Castner, Suzanne; Lehman, Ronald A., Jr.; Ling, Geoffrey S. F.; Symes, Aviva J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Dmitriev, AE (reprint author), Walter Reed Army Med Ctr, Spine Res Ctr, POB 59037, Washington, DC 20012 USA. EM aedortho@gmail.com RI Symes, Aviva/S-7471-2016 OI Symes, Aviva/0000-0003-2557-9939 NR 46 TC 8 Z9 9 U1 1 U2 1 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD AUG 17 PY 2011 VL 93A IS 16 BP 1488 EP 1499 DI 10.2106/JBJS.J.00904 PG 12 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 812EB UT WOS:000294272800003 PM 22204004 ER PT J AU Zheng, LQ Li, ZR Bourdo, S Khedir, KR Asar, MP Ryerson, CC Biris, AS AF Zheng, Liqiu Li, Zhongrui Bourdo, Shawn Khedir, Khedir R. Asar, Madhu P. Ryerson, Charles C. Biris, Alexandru S. TI Exceptional Superhydrophobicity and Low Velocity Impact Icephobicity of Acetone-Functionalized Carbon Nanotube Films SO LANGMUIR LA English DT Article ID ICE ADHESION; WETTING HYSTERESIS; TUNGSTEN NANORODS; SURFACES; EVAPORATION; COATINGS; POLYMER; WETTABILITY; FABRICATION; REPELLENT AB We present a simple method to produce carbon nanotube-based films with exceptional superhydrophobicity and impact icephobicity by depositing acetone-treated single-walled carbon nanotubes on glass substrates. This method is scalable and can be adopted for any substrate, both flexible and rigid. These films have indicated a high contact angle, in the vicinity of 170 degrees, proved both by static and dynamic analysis processes. The dynamic evaporation studies indicated that a droplet deposited on the treated films evaporated in the constant contact angle mode for more than 80% of the total evaporation time, which is definitely a characteristic of superhydrophobic surfaces. Furthermore, the acetone-functionalized films showed a strong ability to mitigate ice accretion from supercooled water droplets (-8 degrees C), when the droplets were found to bounce off the films tilted at 30 degrees. The untreated nanotube films did not indicate similar behavior, and the supercooled water droplets remained attached to the films' surfaces. Such studies could be the foundation of highly versatile technologies for both water and ice mitigation. C1 [Zheng, Liqiu; Li, Zhongrui; Bourdo, Shawn; Khedir, Khedir R.; Asar, Madhu P.; Biris, Alexandru S.] Univ Arkansas, Dept Chem, Dept Appl Sci, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Ryerson, Charles C.] USA, Terr & Cryospher Sci Branch, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr,Corps Engineers, Hanover, NH 03755 USA. RP Zheng, LQ (reprint author), Univ Arkansas, Dept Chem, Dept Appl Sci, Nanotechnol Ctr, Little Rock, AR 72204 USA. EM lxzheng@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU DOD [W912HZ-09-2-0008]; Arkansas Science and Technology Authority (ASTA) [08-CAT-03] FX This research was partially supported by the DOD (Grant No. W912HZ-09-2-0008). Also the financial support of the Arkansas Science and Technology Authority (ASTA) grant # 08-CAT-03 is highly appreciated. The editorial assistance of Dr. Marinelle Ringer is also acknowledged. We also acknowledge the work done by Mr. Harry L. Maddox in creating the composite drop sequence images along with image enhancements from the individual JPEG frames that were derived from the high-speed videos. NR 55 TC 42 Z9 43 U1 1 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD AUG 16 PY 2011 VL 27 IS 16 BP 9936 EP 9943 DI 10.1021/la201548k PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 804OI UT WOS:000293662800037 PM 21740070 ER PT J AU Knox, J Orchowski, J Scher, DL Owens, BD Burks, R Belmont, PJ AF Knox, Jeffrey Orchowski, Joseph Scher, Danielle L. Owens, Brett D. Burks, Robert Belmont, Philip J., Jr. TI The Incidence of Low Back Pain in Active Duty United States Military Service Members SO SPINE LA English DT Article DE epidemiology; low back pain; military; demographic ID RISK-FACTORS; MARITAL DISSATISFACTION; NATIONAL SURVEYS; NECK PAIN; PREVALENCE; HEALTH; POPULATION; INJURY; COHORT; ADULTS AB Study Design. Epidemiological study. Objective. To investigate the incidence and risk factors for developing low back pain in active duty military population to include age, sex, race, and rank, and military service. Summary of Background Data. Low back pain is among the most common musculoskeletal conditions worldwide and is estimated to affect nearly two-thirds of the US population at some point in their lives. Low back pain is a multifactorial disease and many risk factors have been implicated including age, race, sex, and marital status. Methods. A query was performed using the US Defense Medical Epidemiology Database (DMED) for the International Classification of Diseases, Ninth Revision, Clinical Modification code for low back pain (724.20). 13,754,261 person-years of data were investigated. Multivariate Poisson regression analysis was used to estimate the rate of low back pain per 1000 person-years, whereas controlling for sex, race, rank, service, age, and marital status. Results. The overall unadjusted incidence rate of low back pain was 40.5 per 1000 person-years. Women, compared with men, had a significantly increased incidence rate ratio for low back pain of 1.45. The incidence rate ratio for the 40+ age group compared with the 20 to 29 years of age group was 1.28. With junior officers as the referent category, junior-and senior-enlisted rank groups had increased incidence rate ratio for low back pain, 1.95 and 1.35, respectively. Each service, when compared with the Marines as the referent category, had a significantly increased incidence rate ratio of low back pain: Army: 2.19, Navy: 1.02, and Air Force: 1.54. Compared with single service members, significantly increased incidence rate ratio for low back pain were seen in married service members: 1.21. Conclusion. Female sex, enlisted rank groups, service in the Army, Navy, or Air Force, age greater than 40 years, and a marital status of married were all risk factors for low back pain. C1 [Knox, Jeffrey; Orchowski, Joseph] Tripler Army Med Ctr, Orthopaed Surg Serv, Dept Surg, Honolulu, HI 96859 USA. [Scher, Danielle L.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Orthopaed Surg Serv, Dept Surg, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Hosp, Orthopaed Surg Serv, Dept Surg, West Point, NY USA. [Burks, Robert] USN, Postgrad Sch, Grad Sch Operat & Informat Sci, Monterey, CA USA. RP Knox, J (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.bruce.knox@us.army.mil RI Burks, Robert/J-2481-2015; OI Burks, Robert/0000-0001-6443-6653; Belmont, Philip/0000-0003-2618-199X NR 51 TC 32 Z9 34 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD AUG 15 PY 2011 VL 36 IS 18 BP 1492 EP 1500 DI 10.1097/BRS.0b013e3181f40ddd PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 803KD UT WOS:000293579300020 PM 21224777 ER PT J AU Das, NC AF Das, Naresh C. TI Tunable infrared plasmonic absorption by metallic nanoparticles SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID LIGHT-EMITTING-DIODES; ENHANCEMENT AB We exploit unique infrared plasmonic absorption properties of gold (Au) nanoparticles in the range of 2.5 to 20 mu m. Fabrication of Au nanoplasmon particles with variable nanometer (nm) scale size and thickness gave us full control of tuning the absorption wavelength in the above infrared (IR) spectral regions. We did not observe polarization dependence for square size plasmon particles. However, by using plateau crescent (metal crescent structure with flat instead of rounded side on the top) metal particles we observed significant polarization effects in IR absorption spectra. We observed that the position of the absorption peak has linear dependence on the size of nanoparticles, and the absorption quantity depends on the density of the nanoparticles per unit area. The proposed nanoplasmon structure can be used to improve the performance of detector and light emitting diode (LED) devices operating in the IR region. (C) 2011 American Institute of Physics. [doi:10.1063/1.3624596] C1 USA, Res Lab, Microphoton Branch, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Res Lab, Microphoton Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM naresh.das@us.army.mil NR 22 TC 12 Z9 12 U1 2 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 2011 VL 110 IS 4 AR 046101 DI 10.1063/1.3624596 PG 3 WC Physics, Applied SC Physics GA 814VC UT WOS:000294484300182 ER PT J AU Suchalkin, S Belenky, G Svensson, SP Laikhtman, B Smirnov, D Tung, LC Bandara, S AF Suchalkin, S. Belenky, G. Svensson, S. P. Laikhtman, B. Smirnov, D. Tung, L. C. Bandara, S. TI In-plane and growth direction electron cyclotron effective mass in short period InAs/GaSb semiconductor superlattices SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ALSB QUANTUM-WELLS; GASB SUPER-LATTICE; MAGNETORESISTANCE; DETECTORS; INTERFACE; RESONANCE AB In plane and growth direction electron effective mass in short period InAs/GaSb semiconductor superlattices (SL) was measured using cyclotron resonance at different orientations of magnetic field with respect to SL growth direction. It was demonstrated that the electron spectrum near the bottom of the SL subband has 3D character, with the in-plane effective masses ranging from 0.023 m(0) to 0.028 m(0) and growth direction effective masses of 0.03-0.034 m(0) depending on the SL period and growth conditions. The measured effective masses are close to those calculated in the weak coupling limit of the Kronig-Penney model. In this limit the SL electron effective mass is a weighted average of the electron effective masses of corresponding bulk materials. Correlation between the magnitude of cyclotron mobility, amplitude of negative magnetoresistance, and steepness of the long wavelength side of the photoluminescence spectrum indicate that the crystalline structure disorder is a major factor contributing to the momentum relaxation time of the electrons. (C) 2011 American Institute of Physics. [doi:10.1063/1.3627171] C1 [Suchalkin, S.; Belenky, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Svensson, S. P.] USA, Res Lab, Adelphi, MD 20783 USA. [Laikhtman, B.] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel. [Smirnov, D.; Tung, L. C.] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Bandara, S.] AMSRD CER NV ST IFT, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Suchalkin, S (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM suchal@ece.sunysb.edu FU National Science Foundation (NSF) [DMR071054]; Night Vision and Electronic Sensors Directorate; State of Florida FX LWIR SL structure used for measurements was provided by Jet Propulsion Laboratory (JPL). The authors are grateful to J. Pellegrino and M. Tidrow for encouragement and support; and to F. Szmulowicz and L. Shvartsman for helpful discussions. This work was supported NSF award DMR071054 and Night Vision and Electronic Sensors Directorate. CR and magnetotransport experiments were done at the National High Magnetic Field Laboratory at Florida State University and supported by the National Science Foundation and the State of Florida. NR 29 TC 9 Z9 9 U1 1 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 2011 VL 110 IS 4 AR 043720 DI 10.1063/1.3627171 PG 5 WC Physics, Applied SC Physics GA 814VC UT WOS:000294484300080 ER PT J AU Honsell, G De Bortoli, M Boscolo, S Dell'Aversano, C Battocchi, C Fontanive, G Penna, A Berti, F Sosa, S Yasumoto, T Ciminiello, P Poli, M Tubaro, A AF Honsell, Giorgio De Bortoli, Marco Boscolo, Sabrina Dell'Aversano, Carmela Battocchi, Cecilia Fontanive, Giampaolo Penna, Antonella Berti, Federico Sosa, Silvio Yasumoto, Takeshi Ciminiello, Patrizia Poli, Mark Tubaro, Aurelia TI Harmful Dinoflagellate Ostreopsis cf. ovata Fukuyo: Detection of Ovatoxins in Field Samples and Cell lmmunolocalization Using Antipalytoxin Antibodies SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID OF-THE-ART; MEDITERRANEAN SEA; PUTATIVE PALYTOXIN; MASS-SPECTROMETRY; PROROCENTRUM-LIMA; OKADAIC ACID; DINOPHYCEAE; OUTBREAK; EXPOSURE; ANALOGS AB Ostreopsis cf. ovata, a benthic dinoflagellate often blooming along the Mediterranean coasts, has been associated with toxic events ranging from dyspnea to mild dermatitis. In late September 2009, an Ostreopsis cf. ovata bloom occurred in the Gulf of Trieste (Northern Adriatic Sea; Italy), causing pruritus and mild dermatitis in beachgoers. An integrated study was initiated to characterize Ostreopsis cells by light and confocal microscopy, PCR techniques, immunocytochemistry, and high resolution liquid chromatography mass spectrometry (HR LC-MS). The presence of Ostreopsis cf. ovata of the Atlantic/Mediterranean clade was unambiguously established by morphological and genetic analyses in field samples. Several palytoxin-like compounds (ovatoxin-a,-b,-c,-d,-e) were identified by HR LC-MS, ovatoxin-a being the most abundant (45-64 pg/cell). Surprisingly, no palytoxin was detected. For the first time, monoclonal and polyclonal antipalytoxin antibodies revealed the intracellular cytoplasmic localization of ovatoxins, suggesting their cross-reactivity with these antibodies. Since harmful dinoflagellates do not always produce toxins, the immunocytochemical localization of ovatoxins, although qualitative, can provide an early warning for toxic Ostreopsis cells before their massive diffusion and/or concentration in seafood. C1 [Boscolo, Sabrina; Tubaro, Aurelia] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Honsell, Giorgio] Univ Udine, Dept Agr & Environm Sci, I-33100 Udine, Italy. [Dell'Aversano, Carmela; Ciminiello, Patrizia] Univ Naples Federico 2, Chem Nat Prod Dept, I-80131 Naples, Italy. [Battocchi, Cecilia; Penna, Antonella] Univ Urbino, Biomol Sci Dept, I-61121 Pesaro, Italy. [Fontanive, Giampaolo; Berti, Federico] Univ Trieste, Chem & Pharmaceut Sci Dept, I-34127 Trieste, Italy. [Yasumoto, Takeshi] Japan Food Res Labs, Tama Lab, Tama, Tokyo 2060025, Japan. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via Alfonso Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it RI Dell'Aversano, Carmela/H-1803-2013 OI Dell'Aversano, Carmela/0000-0001-8337-3029 FU Regional Governement of Friuli Venezia Giulia (Udine, Italy); Ministry of Education, University and Research, PRIN FX Financial support from Regional Governement of Friuli Venezia Giulia (Udine, Italy) and Ministry of Education, University and Research, PRIN. Thanks to Professors F. Benedetti, E. Fattorusso, R Marzari, and Dr. F. Kokelj for their helpful discussions and Dr. M. Stebel, Mr. C. Gamboz, Dr. G. Del Favero, and Dr. M. Pelin for their technical assistance. NR 49 TC 21 Z9 22 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 15 PY 2011 VL 45 IS 16 BP 7051 EP 7059 DI 10.1021/es201373e PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 805VZ UT WOS:000293758400045 PM 21756000 ER PT J AU Ries, AJ Hopfinger, JB AF Ries, Anthony J. Hopfinger, Joseph B. TI Magnocellular and parvocellular influences on reflexive attention SO VISION RESEARCH LA English DT Article DE Involuntary; Attention capture; ERP; P1; P3; P300 ID ONSET CAPTURES ATTENTION; VISUAL-ATTENTION; SPATIAL ATTENTION; VISUOSPATIAL ATTENTION; NEURAL BASIS; CONTINGENT; INFORMATION; INHIBITION; GUIDANCE; MOTION AB Previous studies have provided conflicting evidence regarding whether the magnocellular (M) or parvocellular (P) visual pathway is primarily responsible for triggering involuntary orienting. Here, we used event-related potentials (ERPs) to provide new evidence that both the M and P pathways can trigger attentional capture and bias visual processing at multiple levels. Specifically, cued-location targets elicited enhanced activity, relative to uncued-location targets, at both early sensory processing levels (indexed by the P1 component) and later higher-order processing stages (as indexed by the P300 component). Furthermore, the present results show these effects of attentional capture were not contingent on the feature congruency between the cue and expected target, providing evidence that this biasing of visual processing was not dependant on top-down expectations or within-pathway priming. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Hopfinger, Joseph B.] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA. [Ries, Anthony J.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Hopfinger, JB (reprint author), Univ N Carolina, Dept Psychol, CB 3270,Davie Hall, Chapel Hill, NC 27599 USA. EM hopfinger@unc.edu FU National Institute of Mental Health [MH066034] FX This research was supported by Grant MH066034 from the National Institute of Mental Health (PI: Joseph B. Hopfinger). NR 47 TC 7 Z9 7 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0042-6989 J9 VISION RES JI Vision Res. PD AUG 15 PY 2011 VL 51 IS 16 BP 1820 EP 1828 DI 10.1016/j.visres.2011.06.012 PG 9 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA 809ZN UT WOS:000294095300004 PM 21723311 ER PT J AU Kulkarni, H Okulicz, JF Grandits, G Crum-Cianflone, NF Landrum, ML Hale, B Wortmann, G Tramont, E Polis, M Dolan, M Lifson, AR Agan, BK Ahuja, SK Marconi, VC AF Kulkarni, Hemant Okulicz, Jason F. Grandits, Greg Crum-Cianflone, Nancy F. Landrum, Michael L. Hale, Braden Wortmann, Glenn Tramont, Edmund Polis, Michael Dolan, Matthew Lifson, Alan R. Agan, Brian K. Ahuja, Sunil K. Marconi, Vincent C. TI Early Postseroconversion CD4 Cell Counts Independently Predict CD4 Cell Count Recovery in HIV-1-Postive Subjects Receiving Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE CD4 count; highly active antiretroviral therapy; outcomes; predictors; treatment response ID PLASMA HIV RNA; VIROLOGICAL RESPONSES; HIV-1-INFECTED PATIENTS; IMMUNOLOGICAL RESPONSE; DISEASE PROGRESSION; PROTEASE INHIBITOR; INFECTED PATIENTS; IMMUNODEFICIENCY; SUPPRESSION; INTERRUPTION AB Background: The relationship between CD4(+) T-cell counts determined soon after seroconversion with HIV-1 (baseline CD4), nadir CD4, and CD4 levels attained during highly active antiretroviral therapy (HAART) is unknown. Methods: Longitudinal, including baseline (at or soon after HIV diagnosis), intermediate (nadir), and distal (post-HAART) CD4(+) T-cell counts were assessed in 1085 seroconverting subjects who achieved viral load suppression from a large well-characterized cohort. The association of baseline with post-HAART CD4(+) T-cell count was determined after adjustment for other relevant covariates. Results: A higher baseline CD4(+) T-cell count predicted a greater postHAART CD4(+) T-cell count, independent of the nadir and other explanatory variables. Together, baseline and nadir strongly predicted the post-HAART CD4(+) count such that a high baseline and lower nadir were associated with a maximal immune recovery after HAART. Likelihood of recovery of the baseline count after HAART was significantly higher when the nadir/ baseline count ratio was consistently >= 0.6. Conclusions: Among viral load suppressing seroconverters, the absolute CD4(+) T-cell count attained post-HAART is highly dependent on both baseline and nadir CD4(+) T-cell counts. These associations further support the early diagnosis and initiation of HAART among HIV-infected persons. C1 [Kulkarni, Hemant; Ahuja, Sunil K.] S Texas Vet Hlth Care Syst, Vet Adm Res Ctr AIDS & HIV Infect 1, San Antonio, TX USA. [Kulkarni, Hemant; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Okulicz, Jason F.; Grandits, Greg; Crum-Cianflone, Nancy F.; Landrum, Michael L.; Hale, Braden; Wortmann, Glenn; Tramont, Edmund; Polis, Michael; Agan, Brian K.; Marconi, Vincent C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Okulicz, Jason F.; Landrum, Michael L.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Grandits, Greg] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Crum-Cianflone, Nancy F.; Hale, Braden] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Tramont, Edmund; Polis, Michael] NIAID, NIH, Bethesda, MD 20892 USA. [Dolan, Matthew] Wilford Hall USAF Med Ctr, Henry M Jackson Fdn, Lackland AFB, TX 78236 USA. [Lifson, Alan R.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol & Biochem, San Antonio, TX 78229 USA. [Marconi, Vincent C.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA. RP Kulkarni, H (reprint author), 12023 Waterway Rdg, San Antonio, TX USA. EM kulkarnih@uthscsa.edu RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-03]; Department of Defense; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System; NIH [R37046326]; VA MERIT award; Elizabeth Glaser Scientist Award; Burroughs Wellcome Clinical Scientist Award in Translational Research; Doris Duke Distinguished Clinical Scientist Award FX Support for this work (IDCRP-000-03) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. This work was also supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and a MERIT (R37046326) award from the NIH to S. K. A. S. K. A. is also supported by a VA MERIT award and is a recipient of the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the Department of Defense or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. NR 45 TC 9 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 15 PY 2011 VL 57 IS 5 BP 387 EP 395 DI 10.1097/QAI.0b013e3182219113 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 800RE UT WOS:000293381300013 PM 21546844 ER PT J AU Krantz, EM Hullsiek, KH Okulicz, JF Weintrob, AC Agan, BK Crum-Cianflone, NF Ganesan, A Ferguson, TM Hale, BR AF Krantz, Elizabeth M. Hullsiek, Katherine Huppler Okulicz, Jason F. Weintrob, Amy C. Agan, Brian K. Crum-Cianflone, Nancy F. Ganesan, Anuradha Ferguson, Tomas M. Hale, Braden R. CA Infect Dis Clin Res Program HIV TI Elevated CD8 Counts During HAART Are Associated With HIV Virologic Treatment Failure SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE human immunodeficiency virus; CD8 count; antiretroviral therapy; HIV viral load suppression; HIV virologic failure ID ACTIVE ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION MARKERS; T-CELL-ACTIVATION; HIV-1-INFECTED PATIENTS; CD38 EXPRESSION; PROTEASE INHIBITOR; PROGNOSTIC VALUE; INFECTED INDIVIDUALS; DISEASE PROGRESSION; VIRAL REPLICATION AB Objective: To evaluate whether elevated CD8 counts are associated with increased risk of virologic treatment failure in HIV-infected individuals. Design: Retrospective cohort study. Methods: US Military HIV Natural History Study participants who initiated highly active antiretroviral therapy (HAART) in 1996-2008 had 6- and 12-month post-HAART HIV RNA <400 copies per milliliter, >= 2 subsequent HIV viral loads and a baseline CD8 count were eligible (n = 817). Baseline was 12 months after the start of HAART, virologic failure (VF) was defined as confirmed HIV RNA >= 400 copies per milliliter, and CD8 counts >= 1200 cells per cubic millimeter were considered elevated. Cox models were used to examine the effect of baseline and time-updated CD8 counts on VF. Results: There were 216 failures for a rate of 5.6 per 100 person-years [95% confidence interval (CI): 4.9 to 6.4]. Among those initiating HAART in 2000-2008, the participants with elevated baseline CD8 counts had significantly greater risk of VF compared with those with baseline CD8 counts <= 600 cells per cubic millimeter [hazard ratio (HR) = 2.68, 95% CI: 1.13 to 6.35]. The participants with elevated CD8 counts at >20% of previous 6-month follow-up visits had a greater risk of failure at the current visit than those who did not (HR = 1.53, 95% CI: 1.14 to 2.06). Those with CD8 counts that increased after the start of HAART had a greater risk of failure than those with CD8 counts that decreased or remained the same (HR = 1.59, 95% CI: 1.19 to 2.13). Conclusions: Initial or serial elevated CD8 counts while on HAART or an increase in CD8 counts from HAART initiation may be early warnings for future treatment failure. C1 [Hale, Braden R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Krantz, Elizabeth M.; Hullsiek, Katherine Huppler; Okulicz, Jason F.; Weintrob, Amy C.; Agan, Brian K.; Crum-Cianflone, Nancy F.; Ganesan, Anuradha; Ferguson, Tomas M.; Infect Dis Clin Res Program HIV] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Krantz, Elizabeth M.; Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Ferguson, Tomas M.] Tripler Army Med Ctr, Infect Dis Serv, Honolulu, HI 96859 USA. RP Hale, BR (reprint author), USN, Hlth Res Ctr, Code 165,140 Sylvester Rd, San Diego, CA 92106 USA. EM Braden.Hale@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-19]; Department of Defense; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX Supported by the Infectious Disease Clinical Research Program (IDCRP; IDCRP-000-19), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. NR 58 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 15 PY 2011 VL 57 IS 5 BP 396 EP 403 DI 10.1097/QAI.0b013e318221c62a PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 800RE UT WOS:000293381300014 PM 21602694 ER PT J AU Arslan, Z Ates, M McDuffy, W Agachan, MS Farah, IO Yu, WW Bednar, AJ AF Arslan, Zikri Ates, Mehmet McDuffy, Wanald Agachan, M. Sabri Farah, Ibrahim O. Yu, W. William Bednar, Anthony J. TI Probing metabolic stability of CdSe nanoparticles: Alkaline extraction of free cadmium from liver and kidney samples of rats exposed to CdSe nanoparticles SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Free cadmium; Cadmium selenide nanoparticle; Metabolic stability; Tetramethylammonium hydroxide; Extraction; Accumulation; ICP-MS ID ATOMIC-ABSORPTION-SPECTROMETRY; QUANTUM DOTS; TETRAMETHYLAMMONIUM HYDROXIDE; BIOLOGICAL DETECTION; NANOCRYSTALS; MICE; METALLOTHIONEIN; TOXICITY; NEPHROTOXICITY; PENETRATION AB Cadmium selenide nanoparticles (CdSe NPs) exhibit novel optoelectronic properties for potential biomedical applications. However, their metabolic stability is not fully understood because of the difficulties in measurement of free Cd from biological tissues of exposed individuals. In this study, alkaline dissolution with tetramethylammonium hydroxide (TMAH) is demonstrated for selective determination of free Cd and intact NPs from liver and kidney samples of animals that were exposed to thiol-capped CdSe NPs. Aqueous suspensions of CdSe NPs (3.2 nm) were used to optimize the conditions for extracting free Cd without affecting NPs. Nanoparticles were found to aggregate when heated in TMAH without releasing any significant Cd to solution. Performance of the method in discriminating free Cd and intact NPs were verified by Dogfish Liver (DOLT-4) certified reference material. The samples from the animals were digested in 4 mL TMAH at 70 degrees C to extract free Cd followed by analysis of aqueous phase by ICP-MS. Both liver and kidney contained significant levels of free Cd. Total Cd was higher in the liver, while kidney accumulated mostly free Cd such that up to 47.9% of total Cd in the kidney was free Cd when NPs were exposed to UV-light before injection. (C) 2011 Elsevier B.V. All rights reserved. C1 [Arslan, Zikri; Ates, Mehmet; McDuffy, Wanald; Agachan, M. Sabri] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Farah, Ibrahim O.] Jackson State Univ, Dept Biol, Jackson, MS 39217 USA. [Yu, W. William] Rice Univ, Houston, TX 77030 USA. [Bednar, Anthony J.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Arslan, Z (reprint author), Jackson State Univ, Dept Chem & Biochem, POB 17910, Jackson, MS 39217 USA. EM zikri.arslan@jsums.edu OI Farah, Ibrahim/0000-0001-8974-8207 FU NIH [G12RR013459, 5 G11 HD046519-05] FX This work is funded in part by grants from NIH-RCMI Program (Grant No. G12RR013459) and NIH-ERDA Program (Grant No. 5 G11 HD046519-05) to Jackson State University. The views expressed herein are those of the authors and do not necessarily represent the official views of the NIH and any of its sub agencies. We thank Robert Brown for his diligent work during the course exposure of the rats to nanoparticles and collection of the organs. NR 36 TC 24 Z9 26 U1 3 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD AUG 15 PY 2011 VL 192 IS 1 BP 192 EP 199 DI 10.1016/j.jhazmat.2011.05.003 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 802BA UT WOS:000293483100024 PM 21700388 ER PT J AU Dubinskii, M Fromzel, V Ter-Gabrielyan, N Serrano, MD Lahera, DE Cascales, C Zaldo, C AF Dubinskii, M. Fromzel, V. Ter-Gabrielyan, N. Serrano, M. D. Lahera, D. E. Cascales, C. Zaldo, C. TI Spectroscopic characterization and laser performance of resonantly diode-pumped Er3+-doped disordered NaY(WO4)(2) SO OPTICS LETTERS LA English DT Article ID STIMULATED-EMISSION; LOCAL DISORDER; CERAMIC LASER; MU-M; ABSORPTION; EFFICIENCY; CRYSTALS; ER3+ AB We report what is believed to be the first resonantly pumped laser operation based on Er3+-doped disordered double tungstate single crystal. Efficient laser operation of an Er3+:NaY(WO4)(2) laser at similar to 1609.6 nm was demonstrated with the naturally wideband, similar to 20 nm, InGaAsP/InP laser diode pumping at similar to 1501 nm. Laser wavelength tunability of similar to 34 nm was also demonstrated based on disorder-broadened emission features of Er3+:NaY(WO4)(2) single crystal. (C) 2011 Optical Society of America C1 [Dubinskii, M.; Fromzel, V.; Ter-Gabrielyan, N.] USA, Res Lab, Attn RDRL SEE M, Adelphi, MD 20783 USA. [Serrano, M. D.; Lahera, D. E.; Cascales, C.; Zaldo, C.] CSIC, Inst Ciencia Mat Madrid, E-28049 Madrid, Spain. RP Dubinskii, M (reprint author), USA, Res Lab, Attn RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil RI CASCALES, CONCHITA/C-3930-2011; Zalldo, Carlos/K-4321-2013; Serrano, Maria Dolores/B-9629-2013 OI CASCALES, CONCHITA/0000-0003-2513-5887; FU United States Army International Technology Center-Atlantic (USAITCA) [W911NF-10-1-0234]; Spanish Ministry of Science and Innovation [MAT2008-06729-C02-01] FX This work has been partially supported by the United States Army International Technology Center-Atlantic (USAITCA) under the contract W911NF-10-1-0234 and by the MAT2008-06729-C02-01 project of the Spanish Ministry of Science and Innovation. NR 15 TC 5 Z9 5 U1 0 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 2011 VL 36 IS 16 BP 3263 EP 3265 PG 3 WC Optics SC Optics GA 807IT UT WOS:000293890800084 PM 21847228 ER PT J AU Morrill, JC Peters, CJ AF Morrill, John C. Peters, C. J. TI Mucosal Immunization of Rhesus Macaques With Rift Valley Fever MP-12 Vaccine SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID VIRUS-VACCINE; IMMUNOGENICITY; PATHOGENICITY; PATHOGENESIS; INFECTION; EFFICACY; IMMUNITY; HAMSTERS; ANIMALS; MONKEYS AB Rhesus macaques given 5 x 10(4) or 1 x 10(5) plaque-forming units (pfu) of Rift Valley fever (RVF) MP-12 vaccine by oral, intranasal drops, or small particle aerosol showed no adverse effects up to 56 days after administration. All monkeys given the vaccine by aerosol or intranasal drops developed 80% plaque reduction neutralization titers of >= 1:40 by day 21 after inoculation. Only 2 of 4 monkeys given the vaccine by oral instillation developed detectable neutralizing antibodies. All monkeys vaccinated by mucosal routes that developed detectable neutralizing antibodies were protected against viremia when challenged with 1 x 10(5) pfu of virulent RVF virus delivered by a small particle aerosol at 56 days after vaccination. A single inoculation of the RVF MP-12 live attenuated vaccine by the aerosol or intranasal route may provide an alternative route of protective immunization to RVFV in addition to conventional intramuscular injection. C1 [Morrill, John C.; Peters, C. J.] USA, Appl Res Div, Med Res Inst Infect Dis, Frederick, MD USA. RP Morrill, JC (reprint author), Univ Texas Med Branch Galveston, Dept Microbiol & Immunol, Galveston, TX 77555 USA. EM jcmorril@utmb.edu FU Department of Defense FX This work was funded by the Department of Defense. NR 30 TC 23 Z9 23 U1 0 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2011 VL 204 IS 4 BP 617 EP 625 DI 10.1093/infdis/jir354 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 799RS UT WOS:000293304400019 PM 21791664 ER PT J AU Krafczyk, MA Asplund, CA AF Krafczyk, Michael A. Asplund, Chad A. TI Exercise-Induced Bronchoconstriction: Diagnosis and Management SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID INDUCED ASTHMA; INDUCED BRONCHOSPASM; MONTELUKAST; CHILDREN; CHALLENGES; SALMETEROL; SYMPTOMS; EFFICACY AB Exercise-induced bronchoconstriction describes the narrowing of the airway that occurs with exercise. More than 10 percent of the general population and up to 90 percent of persons previously diagnosed with asthma have exercise-induced bronchoconstriction. Common symptoms include coughing, wheezing, and chest tightness with exercise; however, many athletes will present with nonspecific symptoms, such as fatigue and impaired performance. Spirometry should be performed initially to evaluate for underlying chronic asthma, although results are often normal. An empiric trial of short-acting beta(2) agonists or additional bronchial provocation testing may be necessary to confirm the diagnosis. Nonpharmacologic treatment options include avoiding known triggers, choosing sports with low minute ventilation, warming up before exercising, and wearing a heat exchange mask in cold weather. Short-acting beta(2) agonists are recommended first-line agents for pharmacologic treatment, although leukotriene receptor antagonists or inhaled corticosteroids with or without long-acting beta, agonists may be needed in refractory cases. If symptoms persist despite treatment, alternative diagnoses such as cardiac or other pulmonary etiologies, vocal cord dysfunction, or anxiety should be considered. (Am Fam Physician. 2011;84(4):427-434. Copyright (C) 2011 American Academy of Family Physicians.) C1 [Krafczyk, Michael A.] St Lukes Hosp & Hlth Network, Primary Care Sports Med Fellowship Program, Bethlehem, PA 18017 USA. [Krafczyk, Michael A.] St Lukes Hosp & Hlth Network, Family Med Residency Program, Bethlehem, PA 18017 USA. [Asplund, Chad A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Krafczyk, MA (reprint author), St Lukes Hosp & Hlth Network, Primary Care Sports Med Fellowship Program, 153 Brodhead Rd, Bethlehem, PA 18017 USA. EM mkrafczyk@gmail.com NR 33 TC 8 Z9 8 U1 0 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 15 PY 2011 VL 84 IS 4 BP 427 EP 434 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980AC UT WOS:000306865000010 PM 21842790 ER PT J AU Van Gessel, Y Klade, CS Putnak, R Formica, A Krasaesub, S Spruth, M Cena, B Tungtaeng, A Gettayacamin, M Dewasthaly, S AF Van Gessel, Yvonne Klade, Christoph S. Putnak, Robert Formica, Alessandra Krasaesub, Somporn Spruth, Martin Cena, Bruno Tungtaeng, Anchalee Gettayacamin, Montip Dewasthaly, Shailesh TI Correlation of protection against Japanese encephalitis virus and JE vaccine (IXIARO (R)) induced neutralizing antibody titers SO VACCINE LA English DT Article DE Japanese encephalitis; Vaccine; Protection; Correlation; Ixiaro ID PHYLOGENETIC ANALYSIS; UNITED-STATES; GENOTYPE; IMMUNIZATION; CHALLENGE; POINTS; CELLS; MICE; ASIA AB Immune sera from volunteers vaccinated in a blinded Phase 3 clinical trial with JE-VAX (R) and a new Japanese encephalitis virus (JEV) vaccine (IC51 or IXIARO), were tested for the ability to protect mice against lethal JEV challenge. Sera from IXIARO vaccinated subjects were pooled into four batches based on neutralizing antibody measured by plaque reduction neutralization test (PRNT(50) titer): high (similar to 200), medium (similar to 40-50), low (similar to 20) and negative (< 10). Pooled sera from JE-VAX vaccinated subjects (PRNT50 titer 55) and pooled JEV antibody negative pre-vaccination sera were used as controls. Groups of ten 6- to 7-week-old female ICR mice were injected intraperitoneally with 0.5 ml of each serum pool diluted 1:2 or 1:10, challenged approximately 18 h later with a lethal dose of either JEV strain SA14 (genotype III) or strain KE-093 (genotype I) and observed for 21 days. All mice in the non-immune serum groups developed clinical signs consistent with JEV infection or died, whereas high titer sera from both IXIARO and JE-VAX sera protected 90-100% of the animals. Statistical tests showed similar protection against both JEV strains SA14 and KE-093 and protection correlated with the anti-JEV antibody titer of IXIARO sera as measured by PRNT50. Ex vivo neutralizing antibody titers showed that almost all mice with a titer of 10 or greater were fully protected. In a separate study, analysis of geometric mean titers (GMTs) of the groups of mice vaccinated with different doses of IXIARO and challenged with JEV SA14 provided additional evidence that titers >= 10 were protective. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Klade, Christoph S.; Formica, Alessandra; Spruth, Martin; Cena, Bruno; Dewasthaly, Shailesh] Intercell AG, Vienna, Austria. [Van Gessel, Yvonne; Krasaesub, Somporn; Tungtaeng, Anchalee; Gettayacamin, Montip] USAMC AFRIMS, Dept Vet Med, Bangkok, Thailand. [Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. RP Dewasthaly, S (reprint author), Intercell AG, Campus Vienna Bioctr 3, Vienna, Austria. EM sdewasthaly@intercell.com FU Intercell AG FX CSK, AF, MS, BC and SD are employed by Intercell AG. This work was partially funded by Intercell AG under a Collaborative Research and Development Agreement (CRADA) between Intercell and the U.S. Army. In addition, one of the authors (RP) is named on the JE inactivated vaccine patent and is a recipient of royalty payments under a licensing agreement. NR 30 TC 27 Z9 27 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 11 PY 2011 VL 29 IS 35 BP 5925 EP 5931 DI 10.1016/j.vaccine.2011.06.062 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 810RX UT WOS:000294145900013 PM 21723353 ER PT J AU Bergmann-Leitner, ES Legler, PM Savranskaya, T Ockenhouse, CF Angov, E AF Bergmann-Leitner, Elke S. Legler, Patricia M. Savranskaya, Tatyana Ockenhouse, Christian F. Angov, Evelina TI Cellular and humoral immune effector mechanisms required for sterile protection against sporozoite challenge induced with the novel malaria vaccine candidate CelTOS SO VACCINE LA English DT Article DE DNA vaccine; Codon harmonization; Immune mechanism; Sporozoite; Protective immunity ID PLASMODIUM-BERGHEI SPOROZOITES; CIRCUMSPOROZOITE PROTEIN; DNA VACCINES; GENE GUN; RESPONSES; EFFICACY; FALCIPARUM; ANTIGEN; ANTIBODIES; SEPARATION AB The malarial protein CelTOS, for cell-traversal protein for ookinetes and sporozoites, from Plasmodium berghei has been shown to mediate malarial invasion of both vertebrate and insect host cells and is required for establishing their successful infections. In the vertebrate host, Plasmodium sporozoites traverse via a complex passage through cellular barriers in the skin and the liver sinusoid to infect hepatocytes. Induction of immunity targeted to molecules involved in sporozoite motility and migration into hepatocytes may lead to abrogation of hepatocyte infection. We have previously demonstrated the potential of CelTOS as a target antigen for a pre-erythrocytic vaccine. The objective of the current study was to determine the potency of different vaccine platforms to induce protective immunity and determine the mode of action in protective immune responses. To this end, inbred Balb/c and outbred ICR mice were immunized with either the recombinant protein adjuvanted with Montanide ISA-720 or with a pCI-TPA plasmid encoding the P. berghei CelTOS (epidermal delivery by gene-gun) and assessed for the induction of protective responses against a homologous P. berghei challenge. Humoral and cellular immune responses induced by the various immunization regimens were evaluated in an effort to establish immune correlates. The results confirm that the CelTOS antigen is a potentially interesting pre-erythrocytic vaccine candidate and demonstrate that both arms of the adaptive immune system are required to mediate complete sterile protection against sporozoite challenge. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Bergmann-Leitner, Elke S.; Ockenhouse, Christian F.; Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Savranskaya, Tatyana] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Legler, Patricia M.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Elke.BergmannLeitner@us.army.mil FU U.S. Agency for International Development [936-3118, GHA-T-00-08-00007-01]; United States Army Medical Research and Materiel Command FX This work was supported by the U.S. Agency for International Development under project number 936-3118, award number GHA-T-00-08-00007-01, and by the United States Army Medical Research and Materiel Command. NR 35 TC 14 Z9 14 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 11 PY 2011 VL 29 IS 35 BP 5940 EP 5949 DI 10.1016/j.vaccine.2011.06.053 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 810RX UT WOS:000294145900015 PM 21722682 ER PT J AU Sulsky, SI Luippold, RS Garman, P Hughes, H Amoroso, PJ AF Sulsky, Sandra I. Luippold, Rose S. Garman, Patrick Hughes, Hayley Amoroso, Paul J. TI Risk of disability for US army personnel vaccinated against anthrax, 1998-2005 SO VACCINE LA English DT Article DE Anthrax vaccine; Disability; Army ID WAR ERA VETERANS; GULF-WAR; ADVERSE EVENTS; PERSIAN-GULF; HEALTH; FORCES; BIRTH; PREGNANCY; GENDER; WOMEN AB To evaluate the potential for long-term or delayed onset health effects, we extended a previous cohort study of disability separation from the army associated with vaccination against anthrax. Analyses included stratified Cox proportional hazards and multiple logistic regression models. Forty-one percent of 1,001,546 soldiers received at least one anthrax vaccination; 5.21% were evaluated for disability. No consistent patterns or statistically significant differences in risk of disability evaluation, disability determination, or reason for disability were associated with anthrax vaccination. There was a dose-related trend in risk of disability for soldiers with 2 years' service, limited to those entering service in 2000 or later. Divergent patterns in risk suggest confounding by temporal or occupational risks of disability. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Sulsky, Sandra I.; Luippold, Rose S.] ENVIRON Int Corp, Amherst, MA 01002 USA. [Garman, Patrick; Hughes, Hayley] Mil Vaccine Agcy, Off Surgeon Gen Army, Falls Church, VA 22041 USA. [Amoroso, Paul J.] USA, Inst Environm Med, Tacoma, WA 98431 USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Sulsky, SI (reprint author), ENVIRON Int Corp, Amherst, MA 01002 USA. EM ssulsky@environcorp.com FU US Department of the Army [W911QY-06-P-0337] FX Funding for this work was provided by the US Department of the Army, contract number W911QY-06-P-0337. NR 26 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 11 PY 2011 VL 29 IS 35 BP 6035 EP 6041 DI 10.1016/j.vaccine.2011.06.028 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 810RX UT WOS:000294145900027 PM 21704102 ER PT J AU Srinivasan, P Beatty, WL Diouf, A Herrera, R Ambroggio, X Moch, JK Tyler, JS Narum, DL Pierce, SK Boothroyd, JC Haynes, JD Miller, LH AF Srinivasan, Prakash Beatty, Wandy L. Diouf, Ababacar Herrera, Raul Ambroggio, Xavier Moch, J. Kathleen Tyler, Jessica S. Narum, David L. Pierce, Susan K. Boothroyd, John C. Haynes, J. David Miller, Louis H. TI Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE AMA1-RON2; malaria; moving junction ID APICAL MEMBRANE ANTIGEN-1; MALARIA VACCINE CANDIDATE; TOXOPLASMA-GONDII; ERYTHROCYTE INVASION; PARASITOPHOROUS VACUOLE; APICOMPLEXAN PARASITES; FALCIPARUM MEROZOITES; INHIBITORY ANTIBODY; ANONYMOUS PROTEIN; MOVING JUNCTION AB The commitment of Plasmodium merozoites to invade red blood cells (RBCs) is marked by the formation of a junction between the merozoite and the RBC and the coordinated induction of the parasitophorous vacuole. Despite its importance, the molecular events underlying the parasite's commitment to invasion are not well understood. Here we show that the interaction of two parasite proteins, RON2 and AMA1, known to be critical for invasion, is essential to trigger junction formation. Using antibodies (Abs) that bind near the hydrophobic pocket of AMA1 and AMA1 mutated in the pocket, we identified RON2's binding site on AMA1. Abs specific for the AMA1 pocket blocked junction formation and the induction of the parasitophorous vacuole. We also identified the critical residues in the RON2 peptide (previously shown to bind AMA1) that are required for binding to the AMA1 pocket, namely, two conserved, disulfide-linked cysteines. The RON2 peptide blocked junction formation but, unlike the AMA1-specific Ab, did not block formation of the parasitophorous vacuole, indicating that formation of the junction and parasitophorous vacuole are molecularly distinct steps in the invasion process. Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate. C1 [Srinivasan, Prakash; Diouf, Ababacar; Miller, Louis H.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. [Herrera, Raul; Narum, David L.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD 20852 USA. [Pierce, Susan K.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA. [Beatty, Wandy L.] Washington Univ, Dept Mol Microbiol, Sch Med, St Louis, MO 63130 USA. [Ambroggio, Xavier] NIAID, Bioinformat & Computat Biosci Branch, Off Cyber Infrastruct & Computat Biol, NIH, Bethesda, MD 20892 USA. [Moch, J. Kathleen; Haynes, J. David] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Tyler, Jessica S.; Boothroyd, John C.] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. RP Srinivasan, P (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. EM srinivasanp@niaid.nih.gov; lmiller@niaid.nih.gov OI Miller, Louis/0000-0003-3420-1284 FU National Institutes of Health FX We thank Drs. Robin F. Anders, Jean-Francois Dubremetz, and Takafumi Tsuboi for antibodies 1F9 (AMA1), 24C6 (RON4), and RON2, respectively; Lydia Kibiuk for help with art illustration; and Dr. Susham Ingavale for critical reading of the manuscript. This work was supported by the National Institutes of Health Intramural Research Program. NR 41 TC 104 Z9 105 U1 1 U2 12 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 9 PY 2011 VL 108 IS 32 BP 13275 EP 13280 DI 10.1073/pnas.1110303108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 804YK UT WOS:000293691400063 PM 21788485 ER PT J AU Zhao, SB Becker, JJ Gagne, MR AF Zhao, Shu-Bin Becker, Jennifer J. Gagne, Michel R. TI Steric Crowding Makes Challenging C-sp3-F Reductive Eliminations Feasible SO ORGANOMETALLICS LA English DT Article ID C-H ACTIVATION; N-FLUOROBENZENESULFONIMIDE; MEDIATED FLUORINATION; HYDRIDE ABSTRACTION; PT(IV) COMPLEXES; INTERNAL OLEFINS; BOND FORMATION; ARYL-IODIDE; PALLADIUM; CATALYSIS AB A high-yielding fluorination of (triphos)Pt-R+ has been achieved using an array of F+ sources, with XeF2 yielding R-F in minutes. The C-F coupling proved to be a stereoretentive process that proceeds via a concerted reductive elimination from a putative dicationic Pt(IV) center. The larger the steric congestion of the (triphos)Pt-C-sp3(+) complexes, the more efficient the fluorination, seemingly a result of sterically accelerated C-F reductive elimination along with simultaneous deceleration of its competing processes (beta-H elimination). C1 [Zhao, Shu-Bin; Gagne, Michel R.] Univ N Carolina, Dept Chem, Caudill Labs, Chapel Hill, NC 27599 USA. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, Caudill Labs, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU NSERC of Canada FX The NIH (GM-60578) and Army Research Office Staff Research Program are thanked for their generous support. S.Z. thanks NSERC of Canada for a Postdoctoral Fellowship. NR 60 TC 39 Z9 39 U1 1 U2 46 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0276-7333 J9 ORGANOMETALLICS JI Organometallics PD AUG 8 PY 2011 VL 30 IS 15 BP 3926 EP 3929 DI 10.1021/om200515f PG 4 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 799SY UT WOS:000293307600005 PM 21869853 ER PT J AU Mogilevsky, G Karwacki, CJ Peterson, GW Wagner, GW AF Mogilevsky, Gregory Karwacki, Christopher J. Peterson, Gregory W. Wagner, George W. TI Surface hydroxyl concentration on Zr(OH)(4) quantified by H-1 MAS NMR SO CHEMICAL PHYSICS LETTERS LA English DT Article ID SOLID-STATE NMR; ANGLE-SPINNING NMR; ZIRCONIUM HYDROXIDE; SULFUR-DIOXIDE; WATER; REMOVAL; POLYMORPHS; ADSORPTION; CHEMISTRY; SUBSTRATE AB Zirconium hydroxide (Zr(OH)(4)) is a catalytic support material whose reactivity depends on intrinsic surface hydroxyl groups. Here we present a H-1 MAS NMR study where we identify bridging and terminal hydroxyl groups along with their concentrations even in completely dehydrated material. The dehydrated material contains 13 mmol/g bridging hydroxyl groups and 3.9 mmol/g terminal hydroxyl groups, yielding a ratio of 3.4:1, and is verified by XPS. Upon hydration, the number of surface hydroxyl groups remains constant while only bulk water is adsorbed on the surface. Knowing both the types and amounts of surface hydroxyl groups on Zr(OH)(4) helps explain the catalytic activity of Zr(OH)(4) in many applications. (C) 2011 Elsevier B.V. All rights reserved. C1 [Mogilevsky, Gregory; Karwacki, Christopher J.; Peterson, Gregory W.; Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Mogilevsky, G (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gregory.mogilevsky.ctr@mail.mil FU ECBC FX This research was performed while the author held a National Research Council Research Associateship Award at ECBC. The authors would also like to thank Joseph A. Rossin from Guild Associates, Inc., 5750 Shier-Rings Rd., Dublin, Ohio 43016 for his XPS work. NR 33 TC 7 Z9 7 U1 3 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD AUG 5 PY 2011 VL 511 IS 4-6 BP 384 EP 388 DI 10.1016/j.cplett.2011.06.072 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 798NI UT WOS:000293214900041 ER PT J AU Hoge, CW AF Hoge, Charles W. TI Interventions for War-Related Posttraumatic Stress Disorder Meeting Veterans Where They Are SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID COGNITIVE PROCESSING THERAPY; RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH PROBLEMS; PRIMARY-CARE; COLLABORATIVE CARE; SOLDIERS; IRAQ; METAANALYSIS; DEPRESSION; COMPONENT C1 Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Off Army Surg Gen, Silver Spring, MD 20910 USA. RP Hoge, CW (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Off Army Surg Gen, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil RI Schueter, nicos/A-3625-2014 NR 22 TC 48 Z9 48 U1 0 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 3 PY 2011 VL 306 IS 5 BP 549 EP 551 DI 10.1001/jama.2011.1096 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 800SH UT WOS:000293386500025 PM 21813436 ER PT J AU Toth, LA Kregel, K Leon, L Musch, TI AF Toth, Linda A. Kregel, Kevin Leon, Lisa Musch, Timothy I. TI Environmental Enrichment of Laboratory Rodents: The Answer Depends on the Question SO COMPARATIVE MEDICINE LA English DT Article ID MALE-MICE; MOUSE BEHAVIOR; AGGRESSIVE-BEHAVIOR; HOUSING CONDITIONS; ANIMAL-EXPERIMENTS; CAGE ENRICHMENT; C57BL/6 MICE; CORTICOSTERONE CONCENTRATIONS; REPRODUCTIVE-PERFORMANCE; HUSBANDRY PROCEDURES AB Efforts to refine the care and use of animals in research have been ongoing for many years and have led to general standardization of rodent models, particularly with regard to animal housing, genetics, and health status. Concurrently, numerous informal practices and recommendations have been promulgated with the laudable intent of promoting general animal wellbeing through so-called enrichment of the cage environment. However, the variety of housing conditions fostered by efforts at environmental enrichment (EE) complicates the goal of establishing standardized or even defined environments for laboratory rodents. Many studies over the years have sought to determine whether or how various enrichment strategies affect the behavior and physiology of laboratory rodents. The findings, conclusions, and interpretations of these studies are mixed, particularly with regard to their application across rodent species, strains, genders, and ages; whether or how they affect the animals and the science; and, in some cases, whether the effects are positive, negative, or neutral in terms of animal wellbeing. Crucial issues related to the application of EE in research settings include its poorly defined effect on the animals, the potential for increased variability in the data, poor definition across labs and in publications, and potential for animal or scientific harm. The complexities, uncertainties, interpretational conundrums, varying conclusions, and lack of consensus in the EE literature warrant careful assessment of the benefits and liabilities associated with implementing such interventions. Reliance on evidence, professional judgment, and performance standards are crucial in the development of EE strategies. C1 [Toth, Linda A.] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA. [Kregel, Kevin] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA USA. [Leon, Lisa] USA, Environm Med Res Inst, Thermal Mt Med Div, Natick, MA 01760 USA. [Musch, Timothy I.] Kansas State Univ, Coll Vet Med, Dept Kinesiol, Manhattan, KS 66506 USA. [Musch, Timothy I.] Kansas State Univ, Coll Vet Med, Dept Anat, Manhattan, KS 66506 USA. [Musch, Timothy I.] Kansas State Univ, Coll Vet Med, Dept Physiol, Manhattan, KS 66506 USA. RP Toth, LA (reprint author), So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA. EM ltoth@siumed.edu FU Southern Illinois University School of Medicine FX The authors thank Taylor Bennett, Peggy Danneman, Phil Davis, JR Haywood, Terri McGaughey, and Alice Ra'anaan for review of preliminary versions of this manuscript. This work was supported in part by the Southern Illinois University School of Medicine. NR 87 TC 25 Z9 27 U1 6 U2 39 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD AUG PY 2011 VL 61 IS 4 BP 314 EP 321 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 915QT UT WOS:000302043200003 PM 22330246 ER PT J AU Noetscher, G Makarov, SN Clow, N AF Noetscher, Gregory Makarov, Sergey N. Clow, Nathan TI Modeling Accuracy and Features of Body-Area Networks with Out-of-Body Antennas at 402 MHz SO IEEE ANTENNAS AND PROPAGATION MAGAZINE LA English DT Editorial Material DE Body area networks; FDTD methods; path loss; electromagnetic propagation; antenna proximity factors ID ABSORBING BOUNDARY-CONDITIONS; PATH LOSS MODEL; RECEIVING ANTENNA; ELECTROMAGNETIC-WAVES; EQUIVALENT-CIRCUIT; PARALLEL FDTD; PROPAGATION; COMMUNICATION; CHANNEL; DIFFRACTION AB Voltage and power transfer functions for the path loss of a 402 MHz body-area network are reviewed. The corresponding expressions are valid in both the near- and far-fields of a transmitting antenna. It was shown that basic FDTD simulations for a homogeneous human-body model, implemented in MATLAB (R), agreed quite well with the advanced FEM solver for an inhomogeneous accurate human-body model. Both methods modeled a voltage transfer function (path loss) for out-of-body dipole antennas at 402 MHz at different antenna locations, as close to the body as 1 5 m m. The reason for the good agreement was that the propagation path was mostly determined by a diffraction of the electromagnetic signal around the body, and not by propagation through the (inhomogeneous) body. Such an observation made it possible to use various homogeneous body meshes in order to study the effect of different body types and positions for out-of-body antennas. A method of creating such meshes using a three-dimensional body scanner is described. For a number of different white-male body meshes, the magnitudes of the received voltages matched exceptionally well when the antenna positions were measured from the top of the head. C1 [Noetscher, Gregory] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Makarov, Sergey N.] Worcester Polytech Inst, ECE Dept, Worcester, MA 01609 USA. [Clow, Nathan] Def Sci & Technol Lab, Ft Halstead, Kent, England. RP Noetscher, G (reprint author), USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM Gregory.Noetscher@us.army.mil; makarov@WPI.EDU NR 51 TC 2 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1045-9243 J9 IEEE ANTENN PROPAG M JI IEEE Antennas Propag. Mag. PD AUG PY 2011 VL 53 IS 4 BP 118 EP 143 DI 10.1109/MAP.2011.6097302 PG 26 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 893SW UT WOS:000300376700012 ER PT J AU Mu, XD Xiang, GS Rathbone, CR Pan, HY Bellayr, IH Walters, TJ Li, Y AF Mu, Xiaodong Xiang, Guosheng Rathbone, Christopher R. Pan, Haiying Bellayr, Ian H. Walters, Thomas J. Li, Yong TI Slow-Adhering Stem Cells Derived from Injured Skeletal Muscle Have Improved Regenerative Capacity SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID PROGENITOR CELLS; IN-VIVO; MATRIX METALLOPROTEINASES; SATELLITE CELL; SELF-RENEWAL; MICROARRAY ANALYSIS; DIFFERENTIATION; EXPRESSION; MICE; MSX1 AB A wide variety of myogenic cell sources have been used for repair of injured and diseased muscle including muscle stem cells, which can be isolated from skeletal muscle as a group of slow-adhering cells on a collagen-coated surface. The therapeutic use of muscle stem cells for improving muscle regeneration is promising; however, the effect of injury on their characteristics and engraftment potential has yet to be described. In the present study, slow-adhering stem cells (SASCs) from both laceration-injured and control noninjured skeletal muscles in mice were isolated and studied. Migration and proliferation rates, multidifferentiation potentials, and differences in gene expression in both groups of cells were compared in vitro. Results demonstrated that a larger population of SASCs could be isolated from injured muscle than from control noninjured muscle. In addition, SASCs derived from injured muscle demonstrated improved migration, a higher rate of proliferation and multidifferentiation, and increased expression of Notch1, STAT3, Msx1, and MMP2. Moreover, when transplanted into dystrophic muscle in MDX/SCID mice, SASCs from injured muscle generated greater engraftments with a higher capillary density than did SASCs from control noninjured muscle. These data suggest that traumatic injury may modify stem cell characteristics through trophic factors and improve the transplantation potential of SASCs in alleviating skeletal muscle injuries and diseases. (Am J Pathol 2011, 179:931-941; DOI: 10.1016/j.ajpath.2011.05.004) C1 [Mu, Xiaodong; Pan, Haiying; Bellayr, Ian H.; Li, Yong] Univ Pittsburgh, Med Ctr, Childrens Hosp Pittsburgh, Lab Mol Pathol,Stem Cell Res Center, Pittsburgh, PA 15219 USA. [Mu, Xiaodong; Xiang, Guosheng; Pan, Haiying; Li, Yong] Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA 15219 USA. [Bellayr, Ian H.; Li, Yong] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15219 USA. [Li, Yong] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15219 USA. [Rathbone, Christopher R.; Walters, Thomas J.] USA, Inst Surg Res, Ibe Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA. RP Li, Y (reprint author), Univ Pittsburgh, Med Ctr, Off 217, Lab Mol Pathol,Stem Cell Res Center, Bridgeside Point 2,450 Technol Dr, Pittsburgh, PA 15219 USA. EM yongli@pitt.eclu FU National Institutes of Health; US Department of Defense FX Supported in part by grants from the National Institutes of Health and the US Department of Defense (Y.L.). NR 73 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD AUG PY 2011 VL 179 IS 2 BP 931 EP 941 DI 10.1016/j.ajpath.2011.05.004 PG 11 WC Pathology SC Pathology GA 865JM UT WOS:000298307200038 PM 21684246 ER PT J AU Palreddy, S Zaghloul, AI Cheung, R AF Palreddy, Sandeep Zaghloul, Amir I. Cheung, Rudolf TI Study of the Effects of the Back Cavity on a Broadband Sinuous Antenna and an Optimized Loaded Back Cavity SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article DE Sinuous antenna; spiral antenna ID SPIRAL ANTENNA AB Sinuous antennas, like spiral antennas, have wideband characteristics, such as constant beam width and low axial ratio over a broad range of frequencies, and thus they are suitable for communicating in transmitting and receiving over bands of frequencies that may encompass multiple channels. In the presence of the back cavity, the performance of the sinuous antenna is affected. The purpose of this paper is to study the affects of the back cavity, and use these findings to build an optimized lossy cavity to improve the performance of the sinuous antenna. The performance of the antenna with and without the back cavity is compared to the antenna with the optimized loaded cavity. C1 [Palreddy, Sandeep; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. [Palreddy, Sandeep; Cheung, Rudolf] Microwave Engn Corp, N Andover, MA 01845 USA. [Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Palreddy, S (reprint author), Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. EM S_Palreddy@microwaveeng.com; amirz@vt.edu; R_Cheung@microwaveeng.com NR 9 TC 3 Z9 3 U1 0 U2 1 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD AUG PY 2011 VL 26 IS 8 BP 660 EP 666 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 864WI UT WOS:000298270800004 ER PT J AU Tipton, CW Ibitayo, D Urciuoli, D Ovrebo, GK AF Tipton, C. Wesley Ibitayo, Dimeji Urciuoli, Damian Ovrebo, Gregory K. TI Development of a 15 kV Bridge Rectifier Module Using 4H-SiC Junction-barrier Schottky Diodes SO IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION LA English DT Article DE Schottky diodes; solid state rectifiers; semiconductor device packaging; partial discharges; dielectric breakdown ID PROGRESS AB To demonstrate higher efficiency and more compact high-voltage power conversion systems, a 15 kV full-bridge rectifier module has been developed by the U. S. Army Research Laboratory. The module utilizes 15 kV, 3 A silicon carbide junction-barrier Schottky diodes manufactured by CREE Inc. In this paper, we will present the analyses, design, and characterization of this module using conventional materials and processes and introduce a novel technique to reduce electric field stress and associated failure modes. C1 [Tipton, C. Wesley; Ibitayo, Dimeji; Urciuoli, Damian; Ovrebo, Gregory K.] USA, Res Lab, Adelphi, MD 20783 USA. RP Tipton, CW (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU U.S. Army contract [DAAD19-01-C-0067] FX The authors gratefully acknowledge the technical contributions of Mrs. Gail Koebke and Mr. Ronald Duane of the Adelphi Laboratory Center. The authors also thank Drs. Sei-Hyung Ryu, Anant Agarwal, and Dave Grider of CREE Inc. for their continued support of silicon carbide research under U.S. Army contract DAAD19-01-C-0067. NR 8 TC 1 Z9 2 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9878 J9 IEEE T DIELECT EL IN JI IEEE Trns. Dielectr. Electr. Insul. PD AUG PY 2011 VL 18 IS 4 BP 1137 EP 1142 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 807SB UT WOS:000293918900030 ER PT J AU Friberg, H Bashyam, H Toyosaki-Maeda, T Potts, JA Greenough, T Kalayanarooj, S Gibbons, RV Nisalak, A Srikiatkhachorn, A Green, S Stephens, HAF Rothman, AL Mathew, A AF Friberg, Heather Bashyam, Hema Toyosaki-Maeda, Tomoko Potts, James A. Greenough, Thomas Kalayanarooj, Siripen Gibbons, Robert V. Nisalak, Ananda Srikiatkhachorn, Anon Green, Sharone Stephens, Henry A. F. Rothman, Alan L. Mathew, Anuja TI Cross-Reactivity and Expansion of Dengue-Specific T cells During Acute Primary and Secondary Infections in Humans SO SCIENTIFIC REPORTS LA English DT Article ID VIRUS-INFECTIONS; DISEASE SEVERITY; HEMORRHAGIC-FEVER; IMMUNE ACTIVATION; MATRIX PROTEIN; RESPONSES; MEMORY; CORRELATE; SEROTYPE; LYMPHOCYTES AB Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A*1101-restricted NS3(133) epitope in a cohort of A11(+) DENV-infected patients throughout acute illness and convalescence. We compared the expansion, serotype-cross-reactivity, and activation of these cells in PBMC from patients experiencing primary or secondary infection and mild or severe disease by flow cytometry. Our results show expansion and activation of DENV-specific CD8(+) T cells during acute infection, which are predominantly serotype-cross-reactive regardless of DENV infection history. These data confirm marked T cell activation and serotype-cross-reactivity during the febrile phase of dengue; however, A11-NS3(133)-specific responses did not correlate with prior antigenic exposure or current disease severity. C1 [Friberg, Heather; Bashyam, Hema; Toyosaki-Maeda, Tomoko; Potts, James A.; Srikiatkhachorn, Anon; Green, Sharone; Rothman, Alan L.; Mathew, Anuja] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA. [Greenough, Thomas] Univ Massachusetts, Sch Med, Dept Pediat, Worcester, MA 01655 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Gibbons, Robert V.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Stephens, Henry A. F.] UCL, Anthony Nolan Trust, London, England. [Stephens, Henry A. F.] UCL, Ctr Nephrol, London, England. RP Mathew, A (reprint author), Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA. EM anuja.mathew@umassmed.edu FU National Institutes of Health [P01 AI34533, U19 AI57319, P30 DK032520] FX This work was funded by the National Institutes of Health, grants P01 AI34533 and U19 AI57319 and core support from NIH P30 DK032520. We would like to thank the donors who generously provided PBMC for use in our studies. We thank Drs. Suchitra Nimmannitya and David Vaughn, as well as the staffs of the Queen Sirikit National Institute for Child Health, the Department of Virology, Armed Forces Research Institute of Medical Sciences and the Department of Transfusion Medicine, Siriraj Hospital, for patient recruitment, blood collection and clinical, virology and HLA information. We would also like to thank Joyce Pepe, Jim Coderre and the UMass Tetramer Core for their time and effort to generate the pMHC multimers, Marcia Woda for sharing her flow cytometry expertise and help with data collection, and Lynne Burns for her technical support. NR 44 TC 27 Z9 27 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD AUG 1 PY 2011 VL 1 AR 51 DI 10.1038/srep00051 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 835QG UT WOS:000296050300001 PM 22355570 ER PT J AU O'Neal, TS Hagerty, DJ AF O'Neal, Troy S. Hagerty, D. J. TI Earth pressures in confined cohesionless backfill against tall rigid walls - a case history SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Article DE earth pressure; arching; vertical shear; temperature effects; surcharge ID RETAINING WALLS AB Earth pressures exerted on tall, rigid retaining walls by confined backfill zones are not well understood. Many factors, such as the complex nature of the soil-structure interaction, soil arching within the backfill zone, vertical shear transfer (downdrag) on the back faces of walls, seasonal temperature effects, and variable methods of construction, affect the earth pressures. The new monolithic wall for the McAlpine Locks replacement project, constructed in Louisville, Kentucky, for the US Army Corps of Engineers, was instrumented to measure earth pressures and temperatures for 2 years, through continuing construction of monolith L-11. Earth pressures appeared to vary with changes in backfill temperature because gauges were not calibrated for thermal expansion contraction of oil in the pressure chambers of the gauges. A temperature calibration and data filtering procedure was developed and verified through laboratory testing, as reported elsewhere. Adjusted pressure data are presented herein to illustrate the effects of compaction procedures and environmental factors. Earth pressure data reflect soil arching and vertical shear effects, roller-compacted concrete wall movement, and surcharging effects. Measured earth pressure values are compared to predictions based on classical theory and arching theory. C1 [Hagerty, D. J.] Construct Solut LLC, Jeffersonville, IN 47130 USA. [O'Neal, Troy S.] USACE, Louisville, KY 40201 USA. RP Hagerty, DJ (reprint author), Construct Solut LLC, Jeffersonville, IN 47130 USA. EM joehagerty@att.net NR 14 TC 4 Z9 5 U1 1 U2 15 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD AUG PY 2011 VL 48 IS 8 BP 1188 EP 1197 DI 10.1139/T11-033 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 833AM UT WOS:000295854000004 ER PT J AU Lehman, RA Lenke, LG AF Lehman, Ronald A. Lenke, Lawrence G. TI Extensive epidural abscess treated with a thoracic laminoplasty SO SPINE JOURNAL LA English DT Editorial Material C1 [Lehman, Ronald A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Div Orthopaed, Potomac, MD 20854 USA. [Lehman, Ronald A.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. [Lenke, Lawrence G.] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA. RP Lehman, RA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Div Orthopaed, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD AUG PY 2011 VL 11 IS 8 BP 798 EP 799 DI 10.1016/j.spinee.2011.05.016 PG 2 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 832AT UT WOS:000295772900023 PM 21763212 ER PT J AU Brunye, TT Ditman, T Mahoney, CR Taylor, HA AF Brunye, Tad T. Ditman, Tali Mahoney, Caroline R. Taylor, Holly A. TI Better you than I: Perspectives and emotion simulation during narrative comprehension SO JOURNAL OF COGNITIVE PSYCHOLOGY LA English DT Article DE Action understanding; Discourse comprehension; Embodied cognition; Emotion; Language; Perspective taking ID LANGUAGE COMPREHENSION; READING-COMPREHENSION; ENVIRONMENTS; MODELS AB Recent studies suggest that readers develop richer multidimensional situation models when they mentally participate as characters in narrative worlds. The present study tested this by examining whether readers differentially represent situational elements when they read narratives using the pronoun "you" or "I" to describe a protagonist, and whether the pronoun "you" would make readers more likely to react to the emotional valence of narratives, embodying the affective states of protagonists. Response times and error rates to comprehension questions demonstrated a richer representation of the spatial organisation of narrative worlds with the pronoun "you" relative to "I". Further, readers were more emotionally reactive to valenced narrative events with the pronoun "you". Results demonstrate that readers differentially represent narrative worlds as a function of perspective, developing richer spatial mental models of layouts and a greater internalisation of emotional events when directly addressed as a protagonist. C1 [Brunye, Tad T.; Ditman, Tali; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Ditman, Tali] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Brunye, Tad T.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. NR 22 TC 12 Z9 12 U1 0 U2 9 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 2044-5911 J9 J COGN PSYCHOL JI J. Cogn. Psychol. PD AUG PY 2011 VL 23 IS 5 BP 659 EP 666 DI 10.1080/20445911.2011.559160 PG 8 WC Psychology, Experimental SC Psychology GA 823ST UT WOS:000295147500012 ER PT J AU Sherwood, JE Fraser, S Citron, DM Wexler, H Blakely, G Jobling, K Patrick, S AF Sherwood, Jeffrey E. Fraser, Susan Citron, Diane M. Wexler, Hana Blakely, Garry Jobling, Kelly Patrick, Sheila TI Multi-drug resistant Bacteroides fragilis recovered from blood and severe leg wounds caused by an improvised explosive device (IED) in Afghanistan SO ANAEROBE LA English DT Article DE Bacteroides fragilis; Multi-drug resistance; nimE; Plasmid; Linezolid ID METRONIDAZOLE RESISTANCE; MECHANISM; CFIA AB This report summarizes the case of a 23 year-old otherwise healthy male that was injured in an improvised explosive device (IED) blast in support of Operation Enduring Freedom (OEF). He sustained bilateral open tibia and fibula fractures in the setting of being exposed to water contaminated with raw sewage. Despite long-term carbapenem therapy, the patient's wounds were repeatedly noted to have purulent drainage during surgical debridement and cultures from these wounds were persistently positive for Bacteroides fragilis. Apparent clinical failure persisted despite the addition of metronidazole to his regimen and an eventual trial of tigecycline. Susceptibility testing of the B. fragilis isolate was performed and resistance to penicillin, clindamycin,metronidazole, cefoxitin, meropenem, imipenem, piperacillin/tazobactam, and tigecycline was confirmed. The presence of a nimE gene on a potentially transferrable plasmid was also confirmed by plasmid sequencing. The only antibiotics that displayed in vitro susceptibility were moxifloxacin and linezolid. These antibiotics were initiated in combination with aggressive irrigation and serial surgical debridement. Conversion to left-sided internal fixation became feasible and his left lower extremity was salvaged without residual evidence of infection. The patient completed an eight week course of combination moxifloxacin and linezolid therapy without adverse event. This B. fragilis isolate displayed simultaneous high-level resistance to multiple antibiotics routinely utilized in anaerobic infections. This was evidenced by clinical failure, in vitro susceptibility testing, and demonstration of genes associated with resistance mechanisms. This case warrants review not only due to the rarity of this event but also the potential implications regarding anaerobic infections in traumatic wounds and the success of a novel treatment regimen utilizing combination therapy with moxifloxacin and linezolid. Published by Elsevier Ltd. C1 [Sherwood, Jeffrey E.; Fraser, Susan] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA. [Citron, Diane M.] RM Alden Res Lab, Culver City, CA 90230 USA. [Wexler, Hana] W Los Angeles VA Med Ctr, Los Angeles, CA 90076 USA. [Blakely, Garry; Jobling, Kelly] Univ Edinburgh, Inst Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland. [Patrick, Sheila] Queens Univ Belfast, Ctr Infect & Immun, Sch Med Dent & Biomed Sci, Belfast BT9 7BL, Antrim, North Ireland. RP Sherwood, JE (reprint author), Walter Reed Army Med Ctr, Dept Infect Dis, Ward 63,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM jeffrey.e.sherwood@us.army.mil; susan.fraser@us.army.mil; d.m.citron@att.net; s.patrick@qub.ac.uk FU George-town University; R.M. Alden Research Laboratory; Walter Reed Army Medical Center FX The authors would like to thank Drs. Itzhak Brook of George-town University, Ellie J.C. Goldstein of the R.M. Alden Research Laboratory, and Gerald Van Horn of Walter Reed Army Medical Center for their contributions, support, and clinical input regarding this case. NR 18 TC 26 Z9 27 U1 2 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1075-9964 J9 ANAEROBE JI Anaerobe PD AUG PY 2011 VL 17 IS 4 SI SI BP 152 EP 155 DI 10.1016/j.anaerobe.2011.02.007 PG 4 WC Microbiology SC Microbiology GA 824ZF UT WOS:000295240000005 PM 21376821 ER PT J AU Carman, RJ Stevens, AL Lyerly, MW Hiltonsmith, MF Stiles, BG Wilkins, TD AF Carman, Robert J. Stevens, Adam L. Lyerly, Matthew W. Hiltonsmith, Megan F. Stiles, Bradley G. Wilkins, Tracy D. TI Clostridium difficile binary toxin (CDT) and diarrhea SO ANAEROBE LA English DT Article DE Clostridium difficile; CDT; Binary toxin; Feces; Ribotype ID PERFRINGENS IOTA-TOXIN; ADP-RIBOSYLTRANSFERASE; GENES; STRAINS; DISEASE; LOCUS; IB AB Clostridium difficile is a major enteropathogen of humans. It produces two main virulence factors, toxins A and B. A third, less well known toxin, C. difficile toxin (CDT), is a binary toxin composed of distinct enzymatic (CdtA) and cell binding/translocation (CdtB) proteins. We used a novel enzyme linked immunoassay (EIA) to detect CdtB protein in feces and culture fluids. Additionally. PCR was used to assay C. difficile isolates from fecal samples for the CDT locus (CdtLoc). Although the results from 80 isolates suggest no relationship between toxin concentrations in situ and in vitro, there is a good correlation between PCR detection of the cdtB gene and EIA detection of CdtB protein in vitro. Possible implications of the detection of CDT in patients are discussed. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Carman, Robert J.; Stevens, Adam L.; Lyerly, Matthew W.; Hiltonsmith, Megan F.; Wilkins, Tracy D.] TechLab Inc, Blacksburg, VA 24060 USA. [Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Toxinol Div, Ft Detrick, MD 21702 USA. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA 17201 USA. RP Carman, RJ (reprint author), TechLab Inc, 2001 Kraft Dr, Blacksburg, VA 24060 USA. EM rjcarman@techlab.com NR 22 TC 17 Z9 17 U1 2 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1075-9964 J9 ANAEROBE JI Anaerobe PD AUG PY 2011 VL 17 IS 4 SI SI BP 161 EP 165 DI 10.1016/j.anaerobe.2011.02.005 PG 5 WC Microbiology SC Microbiology GA 824ZF UT WOS:000295240000007 PM 21376825 ER PT J AU Xu, XJ Turner, CA Santee, WR AF Xu, Xiaojiang Turner, Chris A. Santee, William R. TI Survival time prediction in marine environments SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Math model; Hypothermia; Dehydration; Immersion; Thermoregulation ID COLD-WATER; MODEL; IMMERSION; EXERCISE; CORE AB One of the most challenging questions regarding aquatic search and rescue or recovery operations is the physiological status of the victims. A Probability of Survival Decision Aid (PSDA) was developed to predict survival time for hypothermia and dehydration during prolonged exposure in marine environments for a wide range of environmental conditions. PSDA calculates the survival time of a victim in the water or floating in an emergency craft as a function of environmental conditions, clothing and human anthropometric parameters. PSDA consists of a human thermoregulatory model and a Graphic User Interface, which manages inputs, run the model and display outputs. PSDA was validated using historical survival data and reports of accidental water immersions. For eight immersion victims of known height and weight, the victims' predicted survival time was either in close agreement or greater than the observed survival time. Additional physiological data from case histories and/or controlled studies are needed to validate the PSDA and to expand its application to other hazardous situations. PSDA is intended to assist the search and rescue personnel in operation optimal planning. Published by Elsevier Ltd. C1 [Xu, Xiaojiang; Santee, William R.] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. [Turner, Chris A.] USCG Res & Dev Ctr, Environm & Waterways Branch, Groton, CT 06320 USA. RP Xu, XJ (reprint author), USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM xiaojiang.xu@us.army.mil FU US Coast Guard FX Authors would like to thank Mr. M. Lewandowski and Mr. A. Allen, US Coast Guard, for their support during this project. We would like to acknowledge and thank Dr. E. Wissler for his role as a consultant to this work, and Dr. R. Hoyt for his leadership, guidance and support. We would also like to thank Mr. T. Patel and Mr. M. Amin for their contribution to develop the Graphic User Interface and our colleagues at USARIEM for their support in various aspects of this work. NR 24 TC 6 Z9 6 U1 2 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 2011 VL 36 IS 6 BP 340 EP 345 DI 10.1016/j.jtherbio.2011.06.009 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA 822BJ UT WOS:000295018400007 ER PT J AU Choe, H Jemielity, S Abraham, J Radoshitzky, SR Farzan, M AF Choe, Hyeryun Jemielity, Stephanie Abraham, Jonathan Radoshitzky, Sheli R. Farzan, Michael TI Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses SO CURRENT OPINION IN MICROBIOLOGY LA English DT Review ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ANGIOTENSIN-CONVERTING ENZYME-2; GENE-EXPRESSION; IRON-METABOLISM; ALPHA-DYSTROGLYCAN; SARS CORONAVIRUS; TACARIBE COMPLEX; CARDIAC-SURGERY; INNATE IMMUNITY; HEPCIDIN AB At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor. Accidental similarities between human TfR1 and TfR1 orthologs of arenaviral host species enable zoonoses, whereas mice and rats are not infectable because they lack these TfR1 determinants of infection. All pathogenic New World arenaviruses bind to a common region of the apical domain of TfR1. The ability of a New World arenavirus to use human TfR1 is absolutely predictive of its ability to cause hemorrhagic fevers in humans. Nonpathogenic arenaviruses, closely related to hemorrhagic fever arenaviruses, cannot utilize human TfR1 but efficiently enter cells through TfR1 orthologs of their native rodent hosts. Mutagenesis studies suggest that minor changes in the entry glycoproteins of these nonpathogenic viruses may allow human transmission. TfR1 is upregulated as a result of iron sequestration during the acute-phase response to infection, and the severity of disease may result from amplification of viral replication during this response. C1 [Farzan, Michael] Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Immunobiol, Southborough, MA 01772 USA. [Choe, Hyeryun; Jemielity, Stephanie; Abraham, Jonathan] Harvard Univ, Childrens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA. [Radoshitzky, Sheli R.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Farzan, M (reprint author), Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Immunobiol, Southborough, MA 01772 USA. EM farzan@hms.harvard.edu FU New England Regional Center for Excellence/Biodefense and Emerging Infectious Disease [U54 AI057159]; New England Primate Research Center [RR000168]; Burroughs Welcome Fund FX This work was supported by New England Regional Center for Excellence/Biodefense and Emerging Infectious Disease (U54 AI057159; HC, SJ, and IMF), the New England Primate Research Center Base Grant, RR000168 (MF) and by the Burroughs Welcome Fund (MF). NR 47 TC 25 Z9 25 U1 1 U2 3 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 1369-5274 J9 CURR OPIN MICROBIOL JI Curr. Opin. Microbiol. PD AUG PY 2011 VL 14 IS 4 BP 476 EP 482 DI 10.1016/j.mib.2011.07.014 PG 7 WC Microbiology SC Microbiology GA 820WS UT WOS:000294937400017 PM 21807555 ER PT J AU Gordon, GE Taylor, LG Fram, DM Coster, TS AF Gordon, Geoffrey E. Taylor, Lockwood G. Fram, David M. Coster, Trinka S. TI A New Tool for the Pharmacovigilance Defense Application System (PVDAS) for Automatic Identification of Pregnancy Periods, Outcomes, and Associated Children in the Military Healthcare System (MHS) Database SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Meeting Abstract C1 [Gordon, Geoffrey E.; Fram, David M.] Oracle Corp, Hlth Sci Global Business Unit, Waltham, MA USA. [Taylor, Lockwood G.; Coster, Trinka S.] USA, Pharmacovigilance Ctr, Off Surg Gen, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD AUG PY 2011 VL 20 SU 1 MA 114 BP S50 EP S50 PG 1 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 821AG UT WOS:000294946600112 ER PT J AU Zornberg, GL Hsu, L Dong, D Wernecke, M Kim, C Southworth, MR Houstoun, M MaCurdy, T Reichman, M Tracy, L Cunningham, F Coster, TS Moreschi, G Chen, A Karkowsky, AM Worrall, C Kelman, J AF Zornberg, Gwen L. Hsu, Lucy Dong, Diane Wernecke, Michael Kim, Clara Southworth, Mary Ross Houstoun, Monika MaCurdy, Thomas Reichman, Marsha Tracy, LaRee Cunningham, Francesca Coster, Trinka S. Moreschi, Gail Chen, Amy Karkowsky, Abraham M. Worrall, Chris Kelman, Jeffrey TI Dronedarone or Amiodarone and Risk of Heart Failure (HF): A Federal Partners Collaboration (FPC) SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Meeting Abstract C1 [Zornberg, Gwen L.; Kim, Clara; Southworth, Mary Ross; Houstoun, Monika; Reichman, Marsha; Tracy, LaRee; Moreschi, Gail; Chen, Amy; Karkowsky, Abraham M.] US FDA, Dept Hlth & Human Serv, Silver Spring, MD USA. [Hsu, Lucy; Coster, Trinka S.] USA, Ctr Hlth Promot, Dept Def, Silver Spring, MD USA. [Dong, Diane; Cunningham, Francesca] Dept Vet Affairs, Ctr Medicat Safety, Hines, IL USA. [Wernecke, Michael; MaCurdy, Thomas] Acumen, Burlingame, CA USA. [MaCurdy, Thomas] Stanford Univ, Stanford, CA 94305 USA. [Worrall, Chris; Kelman, Jeffrey] Dept Hlth & Human Serv, Ctr Medicare & Medicaid Serv, Washington, DC USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD AUG PY 2011 VL 20 SU 1 MA 59 BP S26 EP S26 PG 1 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 821AG UT WOS:000294946600059 ER PT J AU Sarkar, J Plackett, TP Gagliano, RA AF Sarkar, Joy Plackett, Timothy P. Gagliano, Ronald A., Jr. TI Periappendiceal Submucosal Abscess Presenting as a Cecal Mass SO SURGICAL INFECTIONS LA English DT Article ID GASTRIC WALL ABSCESS; ESOPHAGEAL TUBERCULOSIS; TUMOR; DIAGNOSIS; APPENDIX AB Background: Submucosal abscesses are rare in the gastrointestinal tract. Although they have been reported throughout the tract, occurrence within the appendix has not been described. Methods: Case report and review of the current literature. Results: We present the case of a patient with a periappendiceal mass found incidentally on workup for anemia. An ileocecectomy was performed for presumed cecal neoplasm. Histologic examination showed a submucosal periappendiceal abscess with no evidence of malignancy. Conclusion: This case is unique because although appendiceal abscesses often occur as a result of acute appendicitis, our patient presented with an incidental periappendiceal submucosal abscess, not preceded by any gastrointestinal infection or surgery. Periappendiceal submucosal abscess should be included in the differential diagnosis of masses found on colonoscopy. C1 [Sarkar, Joy; Plackett, Timothy P.; Gagliano, Ronald A., Jr.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Gagliano, RA (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM ronald.gagliano@amedd.army.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-2964 J9 SURG INFECT JI Surg. Infect. PD AUG PY 2011 VL 12 IS 4 BP 321 EP 323 DI 10.1089/sur.2010.053 PG 3 WC Infectious Diseases; Surgery SC Infectious Diseases; Surgery GA 820BJ UT WOS:000294880200011 PM 21859336 ER PT J AU Bouldin, R Ravichandran, S Kokil, A Garhwal, R Nagarajan, S Kumar, J Bruno, FF Samuelson, LA Nagarajan, R AF Bouldin, Ryan Ravichandran, Sethumadhavan Kokil, Akshay Garhwal, Rahul Nagarajan, Subhalakshmi Kumar, Jayant Bruno, Ferdinando F. Samuelson, Lynne A. Nagarajan, Ramaswamy TI Synthesis of polypyrrole with fewer structural defects using enzyme catalysis SO SYNTHETIC METALS LA English DT Article DE Conducting polymer; Polypyrrole; Enzymatic; Oxidoreductases; Soybean peroxidase ID HORSERADISH-PEROXIDASE; CONDUCTING POLYMERS; SOYBEAN PEROXIDASE; PYRROLE; TEMPERATURE; POLYMERIZATION; OXIDATION; FILMS AB Enzymatic polymerization is an environmentally friendly alternative route for the synthesis of advanced pi-functional materials. Until recently, synthetic methods for production of polypyrrole (PPy) were confined to the use of chemical oxidants or electrochemical methods. Here, we report the low temperature, oxidative polymerization of pyrrole using soybean peroxidase as the catalyst in aqueous non-toxic media. In addition to the benefits of the mild synthetic conditions, enzyme catalysis also affords PPy with fewer structural defects. Poly(sodium 4-styrenesulfonate) (PSS) was used as a charge-balancing dopant and dispersant for PPy to monitor changes in the absorption spectra of the polymer over time. However, the polymerization methodology is amenable to other dopants, including small molecule dopants like 10-camphor sulfonic acid. Spectroscopic characterization indicated that the PPy was conductive, and was produced in higher yields and at faster rates at lower temperatures. Careful temperature control combined with the appropriate choice of dopant ensured production of more electrically conductive PPy with conductivities that exceeded 3 S/cm. UV-Vis spectroscopy was used to provide evidence of favorable interactions between pyrrole and the dopant that may have facilitated the reaction. These interactions, combined with a low synthesis temperature and controlled enzyme-catalyzed radical generation, synergistically favored the formation of PPy with fewer defects and a more linear structure. (C) 2011 Elsevier B.V. All rights reserved. C1 [Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. [Kumar, Jayant; Nagarajan, Ramaswamy] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Nagarajan, Subhalakshmi; Bruno, Ferdinando F.; Samuelson, Lynne A.] USA, Ctr Dev & Engn, Natick, MA 01760 USA. [Kumar, Jayant] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Ravichandran, Sethumadhavan; Kokil, Akshay; Garhwal, Rahul; Nagarajan, Subhalakshmi] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Bouldin, Ryan] Univ Massachusetts, Dept Chem Engn, Lowell, MA 01854 USA. RP Nagarajan, R (reprint author), Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. EM ramaswamy_nagarajan@uml.edu RI Kokil, Akshay/A-6886-2009 OI Kokil, Akshay/0000-0002-8295-2878 FU University of Massachusetts-Lowell; US Army; Tripathy Summer Graduate Fellowship FX Support from University of Massachusetts-Lowell, new faculty start-up fund, the US Army's Student Temporary Employment Program, and the Tripathy Summer Graduate Fellowship is gratefully acknowledged. The authors thank Professors Daniel Sandman and James Whitten for their insightful discussions and support. NR 35 TC 18 Z9 18 U1 3 U2 21 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0379-6779 J9 SYNTHETIC MET JI Synth. Met. PD AUG PY 2011 VL 161 IS 15-16 BP 1611 EP 1617 DI 10.1016/j.synthmet.2011.05.026 PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer Science SC Materials Science; Physics; Polymer Science GA 821JQ UT WOS:000294971700025 ER PT J AU Wroblewski, K Sen, HN Yeh, S Faia, L Li, ZG Sran, P Gangaputra, S Vitale, S Sherry, P Nussenblatt, R AF Wroblewski, Keith Sen, H. Nida Yeh, Steven Faia, Lisa Li, Zhuging Sran, Pushpa Gangaputra, Sapna Vitale, Susan Sherry, Patti Nussenblatt, Robert TI Long-term daclizumab therapy for the treatment of noninfectious ocular inflammatory disease SO CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE LA English DT Article ID WEGENERS-GRANULOMATOSIS; AUTOIMMUNE-DISEASES; UVEITIS; MALIGNANCIES; RITUXIMAB; SAFETY; AGENTS; TRIAL; RISK AB Objective: Safety and efficacy of daclizumab during an 11-year period. Design: Structured, retrospective chart review. Participants: Thirty-nine patients. Methods: Patients with chronic, noninfectious intermediate and/or posterior uveitis. Results: Thirty-nine patients (78 eyes) were treated for a mean of 40.3 months. Visual acuity improved by 2 lines in the better eye in 7 patients (18.4%) and worsened by 2 lines in 6 patients (15.8%) with a mean of 2.8 Snellen lines of vision lost per eye. Six eyes with vitreous cell less than grade 2 lost 2 lines of vision and 7 eyes with less than grade 2 vitreous cell improved 2 lines. Mean number of immunosuppressive medications per patient decreased from 1.89 medications/patient to 1.17 medications/patient. The average number of periocular injections per patient was 1.46 (range, 0-9). The mean number of flares was 2.05/patient (range, 0-12), with the rate being 0.62 flares per patient-year. Four patients developed cancer during the course of this study. Mean time to onset of malignancy was 26 months and the mean age in this group was 49 years. Conclusions: Daclizumab demonstrated efficacy in the reduction of concomitant immunosuppressive medication, stabilization of visual acuity, and the prevention of uveitic flares in most cases. Dermatologic complications were the most frequently observed adverse event in our series. Four patients developed solid tumor malignancies during this 11-year period. C1 [Wroblewski, Keith] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Wroblewski, Keith; Sen, H. Nida; Yeh, Steven; Faia, Lisa; Li, Zhuging; Sran, Pushpa; Gangaputra, Sapna; Vitale, Susan; Sherry, Patti; Nussenblatt, Robert] NIH, Immunol Lab, Bethesda, MD 20892 USA. RP Wroblewski, K (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. EM keith.wroblewski@amedd.army.mil FU Heed Ophthalmic Fellowship Grant FX Dr. Yeh received a Heed Ophthalmic Fellowship Grant for research. NR 25 TC 11 Z9 12 U1 0 U2 1 PU CANADIAN OPHTHAL SOC PI OTTAWA PA 1525 CARLING AVE SUITE 610, OTTAWA, ONTARIO K1Z 8R9, CANADA SN 0008-4182 J9 CAN J OPHTHALMOL JI Can. J. Opthalmol.-J. Can. Opthalmol. PD AUG PY 2011 VL 46 IS 4 BP 322 EP 328 DI 10.1016/j.jcjo.2011.06.008 PG 7 WC Ophthalmology SC Ophthalmology GA 819AS UT WOS:000294798400007 PM 21816251 ER PT J AU Jaramillo, AM Douglas, TA Walsh, ME Trainor, TP AF Jaramillo, Ashley M. Douglas, Thomas A. Walsh, Marianne E. Trainor, Thomas P. TI Dissolution and sorption of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 2,4,6-trinitrotoluene (TNT) residues from detonated mineral surfaces SO CHEMOSPHERE LA English DT Article DE Dissolution; Sorption; Explosive residue; TNT; RDX ID NITROAROMATIC EXPLOSIVES; COMPOSITION-B; SOIL; WATER; METABOLITES; SOLUBILITY; TRANSPORT; HMX; OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE; TEMPERATURE AB Composition B (Comp B) is a commonly used military formulation composed of the toxic explosive compounds 2,4,6-trinitrotoluene (TNT), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Numerous studies of the temporal fate of explosive compounds in soils, surface water and laboratory batch reactors have been conducted. However, most of these investigations relied on the application of explosive compounds to the media via aqueous addition and thus these studies do not provide information on the real world loading of explosive residues during detonation events. To address this we investigated the dissolution and sorption of TNT and RDX from Comp B residues loaded to pure mineral phases through controlled detonation. Mineral phases included nontronite, vermiculite, biotite and Ottawa sand (quartz with minor calcite). High Performance Liquid Chromatography and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy were used to investigate the dissolution and sorption of TNT and RDX residues loaded onto the mineral surfaces. Detonation resulted in heterogeneous loading of TNT and RDX onto the mineral surfaces. Explosive compound residues dissolved rapidly (within 9 h) in all samples but maximum concentrations for TNT and RDX were not consistent over time due to precipitation from solution, sorption onto mineral surfaces, and/or chemical reactions between explosive compounds and mineral surfaces. We provide a conceptual model of the physical and chemical processes governing the fate of explosive compound residues in soil minerals controlled by sorption-desorption processes. Published by Elsevier Ltd. C1 [Jaramillo, Ashley M.; Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Jaramillo, Ashley M.; Trainor, Thomas P.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Walsh, Marianne E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Douglas, TA (reprint author), Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM thomas.a.douglas@usace.army.mil NR 42 TC 6 Z9 6 U1 0 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD AUG PY 2011 VL 84 IS 8 BP 1058 EP 1065 DI 10.1016/j.chemosphere.2011.04.066 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 815HD UT WOS:000294515800005 PM 21601233 ER PT J AU Chappell, MA Miller, LF George, AJ Pettway, BA Price, CL Porter, BE Bednar, AJ Seiter, JM Kennedy, AJ Steevens, JA AF Chappell, Mark A. Miller, Lesley F. George, Aaron J. Pettway, Brad A. Price, Cynthia L. Porter, Beth E. Bednar, Anthony J. Seiter, Jennifer M. Kennedy, Alan J. Steevens, Jeffery A. TI Simultaneous dispersion-dissolution behavior of concentrated silver nanoparticle suspensions in the presence of model organic solutes SO CHEMOSPHERE LA English DT Article DE Nanoparticles; Organics; Dispersion; Dissolution ID CHLAMYDOMONAS-REINHARDTII; CELLULAR INTERACTION; NANOSILVER TOXICITY; ION RELEASE; WATER; OXYGEN; MECHANISMS; PHYSIOLOGY; OXIDATION; KINETICS AB The premise of the nanotechnology revolution is based on the increased surface reactivity of nanometer-sized particles. Thus, these newly realized applications of noble metal nanoparticles introduce new concerns about the environmental fate of these materials if released during use or product disposal. In this paper, the focus is on silver nanoparticles, a known biocidal agent. In particular, this work explores the effect of model solutes chosen for their simple chemical structure yet their ability to simulate chemical attributes common to soil humic material: a chelating molecule, EDTA; a nonionic surfactant. Brij 35; and a large polysaccharide, alginic acid. Batch systems containing concentrated (1600 mg L(-1)) silver nanoparticle (nAg) suspensions were equilibrated with varying additions of EDTA, Brij 35, or alginic acid to solutions containing 1 or 100 mM NaNO(3) background electrolyte. In general, both EDTA and alginate were shown to exhibit poor control over nAg dispersion stability, while Brij 35 served as a good dispersant of nAg particles, showing little difference in particle size with respect to electrolyte concentration. The data also show that loading of the model organic compounds resulted in the supersaturation of dissolved Ag for most of the systems. Mechanisms by which these occurred are discussed in more detail. The evidence suggests that regardless of the effect of humics on the stability of nAg dispersions in aqueous systems, polymer loading may enhance the dissolution and release of dissolved Ag into the environment. Published by Elsevier Ltd. C1 [Chappell, Mark A.; Miller, Lesley F.; Price, Cynthia L.; Bednar, Anthony J.; Seiter, Jennifer M.; Kennedy, Alan J.; Steevens, Jeffery A.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [George, Aaron J.; Pettway, Brad A.; Porter, Beth E.] SpecPro Inc, Huntsville, AL USA. RP Chappell, MA (reprint author), USA, Engn Res & Dev Ctr, Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mark.a.chappell@usace.army.mil NR 54 TC 30 Z9 30 U1 4 U2 88 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD AUG PY 2011 VL 84 IS 8 BP 1108 EP 1116 DI 10.1016/j.chemosphere.2011.04.040 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 815HD UT WOS:000294515800012 PM 21550097 ER PT J AU Adler, AB Britt, TW Castro, CA McGurk, D Bliese, PD AF Adler, Amy B. Britt, Thomas W. Castro, Carl Andrew McGurk, Dennis Bliese, Paul D. TI Effect of Transition Home From Combat on Risk-Taking and Health-Related Behaviors SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH; TRAUMATIC EVENTS; SOLDIERS; DEPLOYMENT; VETERANS; EXPOSURE; PEACEKEEPERS; CONSISTENCY; REENTRY; STRESS AB Transition home following a combat deployment involves a period of adjustment. Exploratory and confirmatory factor analyses of a new 16-item transition scale were conducted with 2 samples and resulted in 4 factors (Benefit, Appreciation, Anger/Alienation, and Guilt/Remorse). In Study 1 (N = 1,65 1), the number of combat events was positively related to Anger/Alienation 4 months later even after controlling for posttraumatic stress disorder (PTSD) symptoms, partial r = .18, p < .001. In Study 2 (NI = 647), after controlling for PTSD symptoms, Anger/Alienation assessed at 4 months postdeployment predicted more risk-taking behaviors 4 months later, partial r = .10, p = .01. Appreciation predicted fewer unhealthy habits, partial r = .13, p = .001, whereas Anger/Alienation predicted more unhealthy habits, partial r = .09, p = .024. Results demonstrate the importance of broadening the conceptualization of adjustment in combat veterans. C1 [Adler, Amy B.; Britt, Thomas W.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29631 USA. [Castro, Carl Andrew] USA, Mil Operat Med Res Program, Med Res & Mat Command, Frederick, MD USA. [McGurk, Dennis; Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Heidelberg, Germany. RP Adler, AB (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM amy.adler@us.army.mil RI Schueter, nicos/A-3625-2014 NR 33 TC 24 Z9 25 U1 1 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2011 VL 24 IS 4 BP 381 EP 389 DI 10.1002/jts.20665 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 816CH UT WOS:000294575800002 PM 21818784 ER PT J AU Sabatini, JJ Nagori, AV Latalladi, EA Poret, JC Chen, G Damavarapu, R Klapotke, TM AF Sabatini, Jesse J. Nagori, Amita V. Latalladi, Eric A. Poret, Jay C. Chen, Gary Damavarapu, Reddy Klapoetke, Thomas M. TI Applications of High-Nitrogen Energetics in Pyrotechnics: Development of Perchlorate-Free Red Star M126A1 Hand-Held Signal Formulations with Superior Luminous Intensities and Burn Times SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Energetic Materials; Environmentally Friendly; High-Nitrogen; Illuminant Compositions; Pyrotechnics AB Perchlorate-free hand-held signal illuminant formulations for the M126A1 red star parachute have been developed. The formulations exhibited longer burn times and higher luminous intensities compared to the US Army in-service M126A1 formulation. The perchlorate-free formulations derive their enhanced performance from the inclusion of strontium bis-(1-methyl-5-nitriminotetrazolate) monohydrate, the choice of magnesium used, and replacing a polyester binder system with an epoxy binder system. C1 [Sabatini, Jesse J.; Nagori, Amita V.; Latalladi, Eric A.; Poret, Jay C.; Chen, Gary] USA, Pyrotech Technol & Prototyping Div, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Damavarapu, Reddy] USA, Energet & Warheads Res & Dev Div, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Klapoetke, Thomas M.] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany. RP Sabatini, JJ (reprint author), USA, Pyrotech Technol & Prototyping Div, ARDEC, Bldg 1515, Picatinny Arsenal, NJ 07806 USA. EM jesse.sabatini@us.army.mil RI Klapoetke, Thomas/B-6055-2014 OI Klapoetke, Thomas/0000-0003-3276-1157 FU Environmental Quality Technology (EQT) program; Armament Research, Development and Engineering Center (ARDEC), Picatinny Arsenal, NJ FX Financial support of this work by the Environmental Quality Technology (EQT) program and Armament Research, Development and Engineering Center (ARDEC), Picatinny Arsenal, NJ is gratefully acknowledged. The authors are indebted to Dr. William S. Eck and Dr. Mark S. Johnson (US Army Public Health Command) for helpful discussions concerning the ongoing toxicology studies of high nitrogen compounds. NR 13 TC 14 Z9 14 U1 0 U2 14 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2011 VL 36 IS 4 BP 373 EP 378 DI 10.1002/prep.201100023 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 818CU UT WOS:000294728200012 ER PT J AU Linkov, I Welle, P Loney, D Tkachuk, A Canis, L Kim, JB Bridges, T AF Linkov, Igor Welle, Paul Loney, Drew Tkachuk, Alex Canis, Laure Kim, J. B. Bridges, Todd TI Use of Multicriteria Decision Analysis to Support Weight of Evidence Evaluation SO RISK ANALYSIS LA English DT Article DE CERCLA; decision analysis; ecological risk assessment; sediment management; weight of evidence ID ECOLOGICAL RISK-ASSESSMENT; CONTAMINATED SITES; SYSTEM; SELECTION; EXPOSURE; DECLINE AB Weight of evidence (WOE) methods are key components of ecological and human health risk assessments. Most WOE applications rely on the qualitative integration of diverse lines of evidence (LOE) representing impact on ecological receptors and humans. Recent calls for transparency in assessments and justifiability of management decisions are pushing the community to consider quantitative methods for integrated risk assessment and management. This article compares and contrasts the type of information required for application of individual WOE techniques and the outcomes that they provide in ecological risk assessment and proposes a multicriteria decision analysis (MCDA) framework for integrating individual LOE in support of management decisions. The use of quantitative WOE techniques is illustrated for a hypothetical but realistic case study of selecting remedial alternatives at a contaminated aquatic site. Use of formal MCDA does not necessarily eliminate biases and judgment calls necessary for selecting remedial alternatives, but allows for transparent evaluation and fusion of individual LOE. It also provides justifiable methods for selecting remedial alternatives consistent with stakeholder and decision-maker values. C1 [Linkov, Igor; Welle, Paul; Loney, Drew; Tkachuk, Alex; Canis, Laure; Kim, J. B.; Bridges, Todd] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Linkov, I (reprint author), USA, Corps Engineers, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil FU Civil Works Basic Research Program; U.S. Army Corps of Engineers FX The authors are grateful to Susan Cormier of the U.S. EPA for her contribution to this effort. We would also like to thank Jeff Keisler of the University of Massachusetts for his comments and John Vogel, Zachary Collier, and Benjamin Trump for editorial support. This effort was sponsored in part by the Civil Works Basic Research Program and Dredged Operations Environmental Research Program by the U.S. Army Corps of Engineers. Permission was granted by the U.S. Army Corps of Engineers Chief of Engineers to publish this material. The views and opinions expressed in this article are those of the individual authors and not those of the U.S. Army, or other sponsor. NR 31 TC 34 Z9 41 U1 3 U2 48 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD AUG PY 2011 VL 31 IS 8 BP 1211 EP 1225 DI 10.1111/j.1539-6924.2011.01585.x PG 15 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 807NR UT WOS:000293906500005 PM 21371061 ER PT J AU Faia, LJ Sen, HN Li, ZQ Yeh, S Wroblewski, KJ Nussenblatt, RB AF Faia, Lisa J. Sen, H. Nida Li, Zhuqing Yeh, Steven Wroblewski, Keith J. Nussenblatt, Robert B. TI Treatment of Inflammatory Macular Edema with Humanized Anti-CD11a Antibody Therapy SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article; Proceedings Paper CT Meeting of the American-Academy-of-Ophthalmology CY AUG, 2008 CL Atlanta, GA SP Amer Acad Ophthalmol ID NATURAL-KILLER-CELLS; IMMUNOSUPPRESSIVE DRUGS; MONOCLONAL-ANTIBODIES; PLAQUE PSORIASIS; EXPERT PANEL; NK CELLS; IN-VIVO; EFALIZUMAB; UVEITIS; EXPRESSION AB PURPOSE. To evaluate the safety and efficacy of treating macular edema, secondary to noninfectious uveitis, with a humanized anti-CD11a antibody. METHODS. Six patients received weekly subcutaneous treatments for 16 weeks according to this open-label, prospective, noncomparative phase I/II trial. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were compared to baseline. Adverse events were recorded and assessed. Blood was sampled to assess the levels of CD56(bright) regulatory NK cells before initiation and after termination of the study. RESULTS. No serious adverse events were reported by the patients. Patients' ages ranged from 22 to 82 years. Mean BCVA improvements were 6.7 +/- 6.9 ETDRS letters in the worse eye and 1.7 +/- 5.2 letters in the better eye. Mean CMT reductions were 128 +/- 105 mu m in the worse eye and 57 +/- 68 mu m in the better eye. Anti-CD11a antibody treatments resulted in an increase in the CD56(bright) regulatory NK cell population in the peripheral blood of the patients. CONCLUSIONS. Anti-CD11a treatment improved visual function, reduced macular thickness, and increased the level of CD56(bright) regulatory NK cells in patients with uveitic macular edema refractory to other immunosuppressive medications. Targeting CD11a may be beneficial in treating other causes of macular edema. (ClinicalTrials.gov number, NCT00280826.) (Invest Ophthalmol Vis Sci. 2011;52:6919-6924) DOI:10.1167/iovs.10-5896 C1 [Faia, Lisa J.; Sen, H. Nida; Li, Zhuqing; Yeh, Steven; Wroblewski, Keith J.; Nussenblatt, Robert B.] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA. [Faia, Lisa J.] Associated Retinal Consultants PC, Royal Oak, MI USA. [Yeh, Steven] Casey Eye Inst, Portland, OR USA. [Wroblewski, Keith J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Sen, HN (reprint author), NEI, Immunol Lab, NIH, 10 Ctr Dr,Bldg 10,Room 10 N 112, Bethesda, MD 20892 USA. EM senh@nei.nih.gov FU Intramural NIH HHS NR 25 TC 6 Z9 6 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD AUG PY 2011 VL 52 IS 9 BP 6919 EP 6924 DI 10.1167/iovs.10-5896 PG 6 WC Ophthalmology SC Ophthalmology GA 815SI UT WOS:000294548300071 PM 21498606 ER PT J AU Cerco, CF AF Cerco, Carl F. TI ASSESSING THE EFFECTS OF NATIVE OYSTER RESTORATION ON CHESAPEAKE BAY WATER QUALITY. SO JOURNAL OF SHELLFISH RESEARCH LA English DT Meeting Abstract C1 [Cerco, Carl F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 0 TC 0 Z9 0 U1 0 U2 11 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 J9 J SHELLFISH RES JI J. Shellfish Res. PD AUG PY 2011 VL 30 IS 2 BP 493 EP 493 PG 1 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 812SC UT WOS:000294312200072 ER PT J AU Montoya-Lerma, J Solarte, YA Giraldo-Calderon, GI Quinones, ML Ruiz-Lopez, F Wilkerson, RC Gonzalez, R AF Montoya-Lerma, James Solarte, Yezid A. Isabel Giraldo-Calderon, Gloria Quinones, Martha L. Ruiz-Lopez, Freddy Wilkerson, Richard C. Gonzalez, Ranulfo TI Malaria vector species in Colombia - A review SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Anopheles; Colombia; review ID ANOPHELES-DARLINGI ROOT; AMPLIFIED POLYMORPHIC DNA; D-AND-K; INTERNAL TRANSCRIBED SPACER; POLYMERASE-CHAIN-REACTION; DIPTERA-CULICIDAE; NUNEZTOVARI DIPTERA; PLASMODIUM-VIVAX; SOUTH-AMERICA; PACIFIC COAST AB Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e. g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species' geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species. C1 [Montoya-Lerma, James; Isabel Giraldo-Calderon, Gloria; Gonzalez, Ranulfo] Univ Valle, Dept Biol, Cali, Colombia. [Solarte, Yezid A.] Univ Valle, Inst Inmunol Valle, Cali, Colombia. [Solarte, Yezid A.] Consorcio Invest Cient Caucaseco, Cali, Colombia. [Quinones, Martha L.] Univ Nacl Colombia, Dept Publ Hlth, Fac Med, Bogota, Colombia. [Ruiz-Lopez, Freddy; Wilkerson, Richard C.] Walter Reed Army Inst Res, Smithsonian Inst, Div Entomol, Museum Support Ctr, Suitland, MD USA. RP Montoya-Lerma, J (reprint author), Univ Valle, Dept Biol, Cali, Colombia. EM james.montoya@correounivalle.edu.co RI Solarte, Yezid/C-1196-2013; OI Solarte, Yezid/0000-0003-4173-0256; Montoya-Lerma, James/0000-0003-2122-1323 FU NIAID/NIH [U19AI089702] FX NIAID/NIH for the establishment of an ICEMR/CLAIM (U19AI089702) NR 169 TC 35 Z9 37 U1 1 U2 11 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 EI 1678-8060 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD AUG PY 2011 VL 106 SU 1 BP 223 EP 238 PG 16 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 814IA UT WOS:000294440600028 PM 21881778 ER PT J AU Asarias, JR Schlussel, AT Cafasso, DE Carlson, TL Kasprenski, MC Washington, EN Lustik, MB Yamamura, MS Matayoshi, EZ Zagorski, SM AF Asarias, Jennifer R. Schlussel, Andrew T. Cafasso, Danielle E. Carlson, Terri L. Kasprenski, Matthew C. Washington, Ezella N. Lustik, Michael B. Yamamura, Mark S. Matayoshi, Eric Z. Zagorski, Stanley M. TI Incidence of postoperative intraabdominal abscesses in open versus laparoscopic appendectomies SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES LA English DT Article DE Appendectomy; Intraabdominal abscess; Laparoscopic ID COMPLICATED APPENDICITIS AB Risk for intraabdominal abscess (IAA) after laparoscopic appendectomy (LA) remains controversial. A 2008 Cochrane Review suggests almost a threefold increase in the incidence of IAA after LA compared with open appendectomy (OA). The authors conducted a retrospective chart review of all appendicitis patients 18 years and older undergoing appendectomy from 1996 to 2007 at one military treatment facility and one civilian hospital in Hawaii. Data collection included demographics, procedure, presence of complicated appendicitis (defined as perforated or gangrenous appendicitis at surgical or pathologic assessment), and presence of postoperative IAA on computed axial tomography (CAT) scan. The review identified 2,464 patients with appendicitis. A total of 1,924 LAs (78%) and 540 OAs (22%) were performed. The comparison of laparoscopic and open appendectomies showed no significant differences in the number of postoperative abscesses (2.2% vs 1.9%; p = 0.74). The patients with a diagnosis of complicated appendicitis were significantly associated with a higher incidence of postoperative abscess formation (67% vs 25%; p < 0.01), which had an unadjusted odds ratio of 6.1 (95% confidence interval [CI], 3.4-11.0; p < 0.01). No significant difference in the development of abscess in patients with complicated appendicitis could be found between LA and OA (5.9% vs 4.1%; p = 0.44). No significant difference in the occurrence of IAA after LA versus OA was found. The patients with complicated appendicitis experienced a greater number of IAA than the patients with uncomplicated appendicitis. C1 [Asarias, Jennifer R.; Schlussel, Andrew T.; Cafasso, Danielle E.; Carlson, Terri L.; Kasprenski, Matthew C.; Washington, Ezella N.; Zagorski, Stanley M.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Yamamura, Mark S.; Matayoshi, Eric Z.] Kaiser Permanente Moanalua Med Ctr, Dept Surg, Honolulu, HI USA. RP Zagorski, SM (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Stanley.zagorski@us.army.mil NR 13 TC 18 Z9 20 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0930-2794 J9 SURG ENDOSC JI Surg. Endosc. PD AUG PY 2011 VL 25 IS 8 BP 2678 EP 2683 DI 10.1007/s00464-011-1628-y PG 6 WC Surgery SC Surgery GA 796AC UT WOS:000293020700036 PM 21416175 ER PT J AU Grandusky, JR Gibb, SR Mendrick, MC Moe, C Wraback, M Schowalter, LJ AF Grandusky, James R. Gibb, Shawn R. Mendrick, Mark C. Moe, Craig Wraback, Michael Schowalter, Leo J. TI High Output Power from 260nm Pseudomorphic Ultraviolet Light-Emitting Diodes with Improved Thermal Performance SO APPLIED PHYSICS EXPRESS LA English DT Article ID TEMPERATURE; DENSITY AB This letter reports on the improved performance of a pseudomorphic ultraviolet light-emitting diode (LED). At 100mA input current, 9.2mW of quasi-CW output power was measured in a calibrated integrating sphere. The addition of a heat sink, required for CW and higher power operation, introduced a numerical aperture of 0.86, and 72mW was measured in pulsed mode at 1.7 A, indicating that the total output power exceeds 100mW when corrected by the coupling factor. The high characteristic temperature of 983 K was instrumental in achieving these record output powers for an LED with wavelength shorter than 265 nm. (C) 2011 The Japan Society of Applied Physics C1 [Grandusky, James R.; Gibb, Shawn R.; Mendrick, Mark C.; Schowalter, Leo J.] Crystal IS Inc, Green Isl, NY 12183 USA. [Moe, Craig; Wraback, Michael] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Grandusky, JR (reprint author), Crystal IS Inc, 70 Cohoes Ave, Green Isl, NY 12183 USA. EM grandusky@crystal-is.com FU Defense Advanced Research Projects Agency (DARPA); Army Research Laboratory (ARL) [W911NF-09-2-0068] FX This material is based upon work partially supported by the Defense Advanced Research Projects Agency (DARPA) under the Compact Mid-Ultraviolet Technology program and a Cooperative Agreement (Number W911NF-09-2-0068) with the Army Research Laboratory (ARL). NR 17 TC 51 Z9 53 U1 5 U2 19 PU JAPAN SOC APPLIED PHYSICS PI TOKYO PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN SN 1882-0778 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PD AUG PY 2011 VL 4 IS 8 AR 082101 DI 10.1143/APEX.4.082101 PG 3 WC Physics, Applied SC Physics GA 812XS UT WOS:000294327500003 ER PT J AU Gutierrez, AP Ponti, L Hoddle, M Almeida, RPP Irvin, NA AF Gutierrez, Andrew Paul Ponti, Luigi Hoddle, Mark Almeida, Rodrigo P. P. Irvin, Nicola A. TI Geographic Distribution and Relative Abundance of the Invasive Glassy-Winged Sharpshooter: Effects of Temperature and Egg Parasitoids SO ENVIRONMENTAL ENTOMOLOGY LA English DT Article DE grape; glassy-winged sharpshooter; Homalodisca vitripennis; invasive species; GIS ID HOMALODISCA-VITRIPENNIS HEMIPTERA; GONATOCERUS-TRIGUTTATUS HYMENOPTERA; COAGULATA SAY HEMIPTERA; LIFE TABLE STATISTICS; DEGREE-DAY VALUES; XYLELLA-FASTIDIOSA; DEVELOPMENTAL BIOLOGY; ASHMEADI HYMENOPTERA; SOUTHERN-CALIFORNIA; DEMOGRAPHIC-MODEL AB The capacity to predict the geographic distribution and relative abundance of invasive species is pivotal to developing policy for eradication or control and management. Commonly used methods fall under the ambit of ecological niche models (ENMs). These methods were reviewed and shortcomings identified. Weather-driven physiologically based demographic models (PBDMs) are proposed that resolve many of the deficiencies of ENMs. The PBDM approach is used to analyze the invasiveness of the polyphagous glassy-winged sharpshooter (Homalodisca vitripennis [Germar]), a pest native to the southeastern United States and northeastern Mexico that extended its range into California in 1989. Glassy-winged sharpshooter vectors the pathogenic bacterium, Xylella fastidiosa (Wells) that causes Pierce's disease in grape and scorch-like diseases in other plants. PBDMs for glassy-winged sharpshooter and its egg parasitoids (Gonatocerus ashmeadi Girault and G. triguttatus Girault) were developed and linked to a PBDM for grape published by Wermelinger et al. (1991). Daily weather data from 108 locations across California for the period 1995-2006 were used to drive the PBDM system, and GRASS GIS was used to map the simulation results. The geographic distribution of glassy-winged sharpshooter, as observed, is predicted to be largely restricted to the warm areas of southern California, with the action of the two egg parasitoids reducing its abundance >90%. The average indispensable mortality contributed by G. triguttatus is <1%. A temperature-dependent developmental rate model for X. fastidiosa was developed that suggests its geographic range is also limited to the warm inland areas of southern California. Biological control of glassy-winged sharpshooter further decreases the pathogen's relative range. Climate warming scenarios of +2 degrees C and +3 degrees C suggest that the distribution and severity of glassy-winged sharpshooter and X. fastidiosa will increase in the agriculturally rich central valley of California. The utility of holistic analyses for formulating control policy and tactics for invasive species is discussed. C1 [Gutierrez, Andrew Paul; Ponti, Luigi] Ctr Anal Sustainable Agr Syst CASAS Gobal, Berkeley, CA 94707 USA. [Ponti, Luigi] Agenzia Nazl Nuove Tecnol Energia & Sviluppo Econ, Lab Gest Sostenibile Agroecosistemi UTAGRI ECO, Ctr Ric Casaccia, I-00123 Rome, Italy. [Hoddle, Mark; Irvin, Nicola A.] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA. [Almeida, Rodrigo P. P.] Univ Calif Berkeley, USA, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. RP Gutierrez, AP (reprint author), Univ Calif Berkeley, Coll Nat Resources, Div Ecosyst Sci, 329 Mulford Hall, Berkeley, CA 94720 USA. EM CASAS.Global@berkeley.edu RI Ponti, Luigi/A-3603-2011 OI Ponti, Luigi/0000-0003-4972-8265 NR 89 TC 11 Z9 11 U1 3 U2 46 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0046-225X J9 ENVIRON ENTOMOL JI Environ. Entomol. PD AUG PY 2011 VL 40 IS 4 BP 755 EP 769 DI 10.1603/EN10174 PG 15 WC Entomology SC Entomology GA 810GH UT WOS:000294113300002 PM 22251675 ER PT J AU Chappell, MA Porter, BE Price, CL Pettway, BA George, RD AF Chappell, Mark A. Porter, Beth E. Price, Cynthia L. Pettway, Brad A. George, Robert D. TI Differential kinetics and temperature dependence of abiotic and biotic processes controlling the environmental fate of TNT in simulated marine systems SO MARINE POLLUTION BULLETIN LA English DT Article DE TNT degradation kinetics; Temperature dependence; Sediment buffering capacity; Fugacity ID QUANTITY-INTENSITY RELATIONSHIPS; SOIL-WATER SLURRIES; RDX; POTASSIUM; SORPTION; TRANSFORMATION; SEDIMENTS; HYDRATION; FUGACITY; ATRAZINE AB This work seeks to understand how the balance of abiotic and biotic kinetic processes in sediments control the residual concentration of TNT in marine systems after release from ocean-dumped source. Kinetics of TNT disappearance were followed using marine sediments at different temperatures and under both biotic and presumably abiotic conditions (through sodium azide addition). Sediments exhibiting the highest rate of TNT disappearance under biotic conditions also exhibited the highest sorption affinity for TNT under abiotic conditions. Significant temperature dependence in the abiotic processes was observed in the diffusion coefficient of TNT and not sediment sorption affinity. At higher temperature, kinetics of biotic processes outpaced abiotic processes, but at low temperature, kinetics of abiotic processes were much more significant. We concluded that the differential influence of temperature on the kinetics of abiotic and biotic processes could provide distinguishing predictions for the potential residual concentration of TNT contamination in marine-sediment systems. Published by Elsevier Ltd. C1 [Chappell, Mark A.; Price, Cynthia L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Porter, Beth E.; Pettway, Brad A.] SpecPro Inc, Huntsville, AL USA. [George, Robert D.] Space & Naval Warfare Syst Ctr, San Diego, CA USA. RP Chappell, MA (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM mark.a.chappell@usace.army.mil FU US Navy's Environmental Sustainability Development; Chief of Naval Operations [N45] FX The US Navy's Environmental Sustainability Development to Integration Program supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N45). The use of trade products or firm names is for descriptive purposes only and does not imply endorsement by the US Government. NR 34 TC 7 Z9 7 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD AUG PY 2011 VL 62 IS 8 BP 1736 EP 1743 DI 10.1016/j.marpolbul.2011.05.026 PG 8 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 809GE UT WOS:000294039000031 PM 21683419 ER PT J AU Rich, J Raviv, A Raviv, N Brietzke, SE AF Rich, Jeremy Raviv, Ayelette Raviv, Nataly Brietzke, Scott E. TI An Epidemiologic Study of Snoring and All-Cause Mortality SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE sleep apnea; snoring; mortality; database study; epidemiology ID SLEEP-APNEA SYNDROME; PORTABLE HOME SLEEP; RISK-FACTOR; POLYSOMNOGRAPHY; HYPERTENSION; POPULATION; DISEASE; MEN AB Objective. Snoring is a common problem that is often associated with obstructive sleep apnea syndrome (OSAS). However, it is suggested that snoring may itself be harmful. Patients with objectively measured snoring were matched against a mortality database and associations were explored. Study Design. Database study. Setting. Community-based use of a portable sleep study device. Subjects and Methods. More than 77,000 patients who underwent a portable sleep study (SNAP Test, SNAP Labs Inc, Wheeling, Illinois) with a detailed, acoustical snoring analysis were matched to the Social Security Death Master File to establish mortality (1653 deaths matched). Snoring indices to include amount (snoring events per hour), volume (dB), and palatal versus nonpalatal snoring were correlated to mortality using stepwise multivariate logistic regression and survival analysis. Results. As expected, increasing age (odds ratio [OR] = 1.84; 95% confidence interval [CI], 1.76-1.93; P < .001), body mass index (BMI) (OR = 1.23; 95% CI, 1.18-1.28; P < .001), and male sex (OR = 1.38; 95% CI, 1.2-1.56; P < .001) were associated with increased all-cause mortality. The presence of increasing OSAS confounded the relationship between snoring and mortality. For patients without OSAS (apnea-hypopnea index [AHI] < 5) and with a BMI < 30 (n = 5955), increasing snoring was associated with an age-and sex-adjusted increase in mortality (OR = 1.16; 95% CI, 1.01-1.32; P = .034). For all patients, increasing nonpalatal snoring was associated with an increase in mortality (OR = 1.21; 95% CI, 1.09-1.35; P < .001) after adjustment for age, sex, BMI, and AHI. Survival analysis produced identical results to logistic regression. Conclusion. In patients without OSAS and with a BMI less than 30, increasing snoring was associated with a significant increase in all-cause mortality. Nonpalatal snoring is associated with an increase in observed all-cause mortality controlling for age, sex, BMI, and AHI. C1 [Rich, Jeremy; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Raviv, Ayelette] Syracuse Univ, Syracuse, NY USA. [Raviv, Nataly] Case Western Reserve Univ, Cleveland, OH 44106 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM SEBrietzke@msn.com FU Snap Diagnostics Inc FX Snap Diagnostics Inc provided unrestricted access to its proprietary database of SNAP study results. Sponsor had no influence over the data analysis or interpretation. NR 12 TC 17 Z9 17 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD AUG PY 2011 VL 145 IS 2 BP 341 EP 346 DI 10.1177/0194599811402475 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 809QG UT WOS:000294071200030 PM 21493281 ER PT J AU Carter, C Stratton, C Mallory, D AF Carter, Catherine Stratton, Carol Mallory, Debra TI Yoga to Treat Nonspecific Low Back Pain SO AAOHN JOURNAL LA English DT Article ID CLINICAL-PRACTICE GUIDELINE; PHYSICIANS; EFFICACY; BELIEFS; COLLEGE; CARE AB Low back pain is common and poses a challenge for clinicians to find effective treatment to prevent it from becoming chronic. Chronic low back pain can have a significant impact on an employee's ability to remain an active and productive member of the work force due to increased absenteeism, duty restrictions, or physical limitations from pain. Low back pain is the most common cause of work-related disability among employees younger than 46 years. Advancing technology and less invasive surgical procedures have not improved outcomes for employees who suffer from low back pain. Most continue to experience some pain and dysfunction after conventional treatments such as injections and surgery. An alternative treatment that could reduce nonspecific chronic low back pain would benefit both employees and employers. Exercising and remaining active are part of most guidelines' routine Care recommendations but are not well defined. C1 [Carter, Catherine] USA, Hlth Clin, Dugway, UT 84022 USA. [Stratton, Carol] Yuma Hlth Clin, Yuma, AZ USA. [Mallory, Debra] Indiana State Univ, Dept Adv Practice, Nursing Program, Terre Haute, IN USA. RP Carter, C (reprint author), USA, Hlth Clin, 5116 Kister Ave, Dugway, UT 84022 USA. EM catherine.carter@us.army.mil NR 30 TC 2 Z9 2 U1 1 U2 9 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0891-0162 J9 AAOHN J JI AAOHN J. PD AUG PY 2011 VL 59 IS 8 SI SI BP 355 EP 361 DI 10.3928/08910162-20110718-01 PG 7 WC Public, Environmental & Occupational Health; Nursing SC Public, Environmental & Occupational Health; Nursing GA 806NR UT WOS:000293815400004 PM 21780737 ER PT J AU Fincher, RK Donovan, M AF Fincher, R. K. Donovan, M. TI Large gastric heterotopia presenting as an obstructing duodenal mass SO ENDOSCOPY LA English DT Editorial Material ID BULB C1 [Fincher, R. K.; Donovan, M.] DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Fincher, R. K.] Med Coll Georgia, Augusta, GA 30912 USA. RP Fincher, RK (reprint author), DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. EM keithfincher@comcast.net NR 5 TC 0 Z9 0 U1 0 U2 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0013-726X J9 ENDOSCOPY JI Endoscopy PD AUG PY 2011 VL 43 SU 2 BP E246 EP E246 DI 10.1055/s-0030-1256452 PG 1 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 806EQ UT WOS:000293789500010 PM 21837595 ER PT J AU Conlan, JV Jarman, RG Vongxay, K Chinnawirotpisan, P Melendrez, MC Fenwick, S Thompson, RCA Blacksell, SD AF Conlan, James V. Jarman, Richard G. Vongxay, Khamphouth Chinnawirotpisan, Piyawan Melendrez, Melanie C. Fenwick, Stanley Thompson, R. C. Andrew Blacksell, Stuart D. TI Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Hepatitis E virus; Swine; Zoonosis; Lao PDR; RNA stabilising buffer ID SWINE-FEVER VIRUSES; PHYLOGENETIC ANALYSIS; SOUTHERN CHINA; EASTERN CHINA; FECAL SAMPLES; INFECTION; TRANSMISSION; PDR; IDENTIFICATION; ANTIBODIES AB The objective of this study was to determine the prevalence and genotypic range of Hepatitis E virus (HEV) in the pig population of northern Lao People's Democratic Republic (PDR). We collected 181 faecal samples from indigenous-breed pigs <= 6 months of age and the faeces was stored in RNA stabilisation buffer due to cold-chain and transport limitations. Twenty-one (11.6%) pigs had detectable HEV RNA and 43.5% of village pig herds were infected. Based on a 240 base pair-nucleotide sequence flanking the junction of open reading frames 1,2 and 3 (ORF1, ORF2 and ORF3) the isolates were phylogenetically classified within genotype 4. Phylogenetic analyses revealed distinct genetic groupings of the Lao HEV isolates and two groups clustered with human and pig HEV isolates from China. This was the first study to demonstrate genotype 4 HEV in Lao PDR and indicates pigs are a potential reservoir for human HEV infection. (C) 2011 Elsevier B.V. All rights reserved. C1 [Conlan, James V.; Fenwick, Stanley; Thompson, R. C. Andrew; Blacksell, Stuart D.] Murdoch Univ, Sch Vet & Biomed Sci, Murdoch, WA 6150, Australia. [Jarman, Richard G.; Chinnawirotpisan, Piyawan; Melendrez, Melanie C.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Vongxay, Khamphouth] Minist Agr & Forestry, Natl Anim Hlth Ctr, Dept Livestock & Fisheries, Vientiane Capital, Laos. [Blacksell, Stuart D.] Mahidol Univ, Fac Trop Med, Oxford Trop Med Res Unit, Bangkok 10400, Thailand. [Blacksell, Stuart D.] Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford OX3 7LJ, England. RP Conlan, JV (reprint author), Food Stand Australia New Zealand, POB 7186, Canberra Bc, ACT 2610, Australia. EM james.conlan@foodstandards.gov.au OI Blacksell, Stuart/0000-0001-6576-726X; Melendrez, Melanie/0000-0002-4811-4467 FU Australian Centre for International Agricultural Research [AH2006/161]; Murdoch University Research Studentship (MURS) FX This work was funded by the Australian Centre for International Agricultural Research (project number AH2006/161), and JVC was supported by a Murdoch University Research Studentship (MURS) award. NR 29 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD AUG PY 2011 VL 11 IS 6 BP 1306 EP 1311 DI 10.1016/j.meegid.2011.04.022 PG 6 WC Infectious Diseases SC Infectious Diseases GA 806JV UT WOS:000293804600020 PM 21550423 ER PT J AU Niemann, JD Lehman, BM Gates, TK Hallberg, NU Elhaddad, A AF Niemann, Jeffrey D. Lehman, Brandon M. Gates, Timothy K. Hallberg, Niklas U. Elhaddad, Aymn TI Impact of Shallow Groundwater on Evapotranspiration Losses from Uncultivated Land in an Irrigated River Valley SO JOURNAL OF IRRIGATION AND DRAINAGE ENGINEERING LA English DT Article DE Evapotranspiration; Groundwater; Alluvium; Conservation; Colorado; Water loss; Irrigation ID ADJUSTED VEGETATION INDEX; WATER-TABLE; SOIL-WATER; BASIN; VARIABILITY; SIMULATION; DISCHARGE; MODELS AB In many agricultural regions of the West, decades of intensive irrigation have produced shallow water tables under not only cultivated fields but also the nearby uncultivated land. It is possible that the high water tables under the uncultivated lands are substantially increasing evapotranspiration (ET) rates, which would represent an unnatural and potentially nonbeneficial consumptive use. The objective of this paper is to quantify loss of water that occurs from uncultivated lands in a semiarid irrigated river valley (the Lower Arkansas River Valley in southeastern Colorado). A remote-sensing algorithm is used to estimate actual ET rates on 16 dates on the basis of Landsat satellite images. On the same dates, water table depths, soil moisture values, and soil water salinities are measured at up to 84 wells distributed across three study sites. On the basis of a water balance of the root zone, it is estimated that 78% of the ET is supplied by groundwater upflux at these sites. It is also observed that the ET and groundwater upflux decrease with increasing water table depth. A regression analysis indicates that the spatial variations in ET are most closely related to variations in vegetation-related attributes, whereas soil moisture and water table depths also explain substantial amounts of the variation. Valley-wide implications for reducing nonbeneficial ET through water table control also are discussed. DOI: 10.1061/(ASCE)IR.1943-4774.0000356. (C) 2011 American Society of Civil Engineers. C1 [Niemann, Jeffrey D.; Lehman, Brandon M.; Gates, Timothy K.; Elhaddad, Aymn] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. [Hallberg, Niklas U.] US Army Corps Engn, Mobile, AL 36602 USA. RP Niemann, JD (reprint author), Colorado State Univ, Dept Civil & Environm Engn, Campus Delivery 1372, Ft Collins, CO 80523 USA. EM jniemann@engr.colostate.edu FU Colorado Water Institute; Colorado Agricultural Experiment Station; U. S. Geological Survey; Southeastern Colorado Water Conservancy District; Lower Arkansas Valley Water Conservancy District; U. S. Bureau of Reclamation FX The authors thank the Colorado Water Institute, the Colorado Agricultural Experiment Station, the U. S. Geological Survey, the Southeastern Colorado Water Conservancy District, the Lower Arkansas Valley Water Conservancy District, and the U. S. Bureau of Reclamation for their financial support; the U. S. Bureau of Reclamation and the Natural Resources Conservation Service for supplying equipment; Jim Hasenack, Larry McElroy, and Dr. D. L. Teeter for granting extensive access to their property; Chad Martin, Emery Crump, Ben Weber, Brian Little, Todd Vandegrift, Amin Haghnegahdar, Mike Coleman, and Matt Bostrom for field assistance; Mike Bartolo for use of the Arkansas Valley Research Center; Enrique Triana, Eric Morway, and Joy Labadie for their technical assistance; and two anonymous reviewers for their helpful suggestions. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the opinions or policies of the U. S. Government. Mention of trade names or commercial products does not constitute their endorsement by the U. S. Government. NR 35 TC 3 Z9 3 U1 0 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9437 EI 1943-4774 J9 J IRRIG DRAIN ENG JI J. Irrig. Drainage Eng-ASCE PD AUG PY 2011 VL 137 IS 8 BP 501 EP 512 DI 10.1061/(ASCE)IR.1943-4774.0000356 PG 12 WC Agricultural Engineering; Engineering, Civil; Water Resources SC Agriculture; Engineering; Water Resources GA 802PQ UT WOS:000293523900004 ER PT J AU Cohen, SP Gambel, JM Raja, SN Galvagno, S AF Cohen, Steven P. Gambel, Jeffrey M. Raja, Srinivasa N. Galvagno, Sam TI The Contribution of Sympathetic Mechanisms to Postamputation Phantom and Residual Limb Pain: A Pilot Study SO JOURNAL OF PAIN LA English DT Article DE Amputation; phantom limb; sympathetic block; residual limb; sympathetically-maintained pain; stump pain ID STELLATE GANGLION; CROSSOVER TRIAL; MAINTAINED PAIN; NERVE INJURY; DOUBLE-BLIND; RISK-FACTORS; AMPUTEES; STUMP; BLOCK; SKIN AB Postamputation pain (PAP) affects over 60% of major limb amputees. One of the main challenges in treating PAP is the difficulty involved in identifying pain mechanism(s), which pertains to both residual limb pain (RIP) and phantom limb pain (PIP). In this study, sympathetic blocks were performed on 17 major limb amputees refractory to treatment, including 2 placebo-controlled blocks done for bilateral amputations. One hour postinjection, mean RLP scores at rest declined from 5.2 (SD 2.8) to 2.8 (SD 2.6) (P = .0002), and PLP decreased from 5.3 (SD 3.1) to 2.3 (SD 2.1) (P = .0009). By 1 week, mean pain scores for RLP and PLP were 4.3 (SD 2.9) and 4.2 (SD 3.0), respectively. Overall, 8 of 16 (50%) patients experienced >= 50% reduction in RLP 1-hour postinjection, with the beneficial effects being maintained at 1 and 8 weeks in 4 and 1 patient(s), respectively. For PLP, 8 of 15 (53%) patients obtained >= 50% decrease in pain 1-hour postblock, with these numbers decreasing to 2 patients at both 1 and 8 weeks. In the 2 bilateral amputees who received controlled injections, mean PLP and RIP at rest scores went from 4.0 and 3.3 to 4.0 and 2.5 1-hour postblock, respectively, on the placebo side. On the treatment side, mean PIP and RIP scores decreased from 7.5 and 6.5, respectively, to 0. Perspective: The results of this study suggest that sympathetic mechanisms play a role in PLP and to a lesser extent, RLP, but that blocks confer long-term benefits in only a small percentage of patients. Published by Elsevier Inc. on behalf of the American Pain Society C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Gambel, Jeffrey M.] Walter Reed Army Med Ctr, Phys Med & Rehabil Div, Dept Orthoped Surg, Washington, DC 20307 USA. [Galvagno, Sam] Johns Hopkins Sch Med, Dept Anesthesiol, Dept Anesthesiol Crit Care Med, Baltimore, MD USA. [Galvagno, Sam] Johns Hopkins Sch Med, Sch Publ Hlth, Baltimore, MD USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu OI Yang, Shuman/0000-0002-9638-0890 FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA FX Supported in part by a Congressional grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, PA. NR 66 TC 8 Z9 9 U1 1 U2 4 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD AUG PY 2011 VL 12 IS 8 BP 859 EP 867 DI 10.1016/j.jpain.2011.01.009 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 807YN UT WOS:000293939000004 PM 21481650 ER PT J AU You, WG Masri, R Romberg, E Driscoll, CF You, T AF You, Wenguang Masri, Radi Romberg, Elaine Driscoll, Carl F. You, Tao TI The Effect of Denture Cleansing Solutions on the Retention of Pink Locator Attachments after Multiple Pulls: An In Vitro Study SO JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY LA English DT Article DE Retention; dental hygiene; overdentures; Locators ID OVERDENTURES; CLEANERS AB Purpose: The effect of denture cleansing solutions and multiple pulls on the retention of pink Locator patrices was studied. Materials and Methods: Five groups of pink Locator attachments (3.0 lb. Light Retention replacement patrix attachments; five in each group) were soaked for the equivalent of 6 months of clinical use in the following solutions: water (control), Efferdent, Polident Overnight, 6.15% sodium hypochlorite (NaOCL, 1:10 dilution), and Listerine mouthwash. A universal testing machine set at a 2 in/min crosshead speed was used to perform 548 pulls (548 cycles of insertion and removal). The reduction in load to dislodgement (retention) after the initial pull and the final pull and the percent reduction in retention after 6 months were compared between the groups using a one-way ANOVA followed by Tukey's Honestly Significant Difference (HSD) Test (alpha = 0.05). Results: Denture cleansing solutions significantly reduced the retentive values of pink Locator attachments after the initial pull (F = 17.435, p < 0.0001). The retentive values of Efferdent, Listerine, Polident Overnight, and water were significantly higher than the retentive value of the attachments soaked in NaOCl. After 6 months of simulated use (548 pulls), the four denture cleansing solutions had significant effects on the retentive values of pink Locator attachments (F = 5.855, p = 0.003). The retentive values for attachments soaked in NaOCl (7.29 +/- 1.0 N) were significantly lower than those of attachments soaked in Listerine (15.82 +/- 4.7 N) and in Polident Overnight (14.41 +/- 3.6 N). These cleansing solutions also had a significant effect on the percentage of retention lost (F = 3.271, p = 0.032). The loss of retention in attachments soaked in Listerine (29 +/- 9%) was significantly lower than attachments soaked in water (53 +/- 12%). The loss of retention in attachments soaked in Efferdent was 49 +/- 9%; in Polident Overnight, 34 +/- 18%; and in NaOCl, 42 +/- 11%. There was no significant difference in the percentage of retention loss between water, Efferdent, NaOCl, and Polident Overnight. There was also no significant difference in the percentage of retention loss between Efferdent, NaOCl, Polident Overnight, and Listerine. Conclusion: NaOCl significantly decreased the retentive value of Locators. Therefore, it should not be routinely recommended for use as a denture cleanser. Listerine significantly increased the retention of the Locator attachments; however, it is premature to recommend Listerine for use as a denture cleanser. C1 [You, Wenguang] Univ Maryland, Sch Dent, Adv Educ Specialty Program Prosthodont, Baltimore, MD 21201 USA. [Masri, Radi] Univ Maryland, Sch Dent, Dept Endodont Prosthodont & Operat Dent, Baltimore, MD 21201 USA. [Romberg, Elaine] Univ Maryland, Sch Dent, Dept Hlth Prevent & Policy, Baltimore, MD 21201 USA. [Driscoll, Carl F.] Univ Maryland, Sch Dent, Postgrad Prosthodont Program, Baltimore, MD 21201 USA. [You, Tao] US Army Trauma & Dent Res Detachment, Brooke Army Med Ctr, Ft Sam Houston, TX USA. RP Masri, R (reprint author), 650 W Baltimore St,Rm 6253, Baltimore, MD 21201 USA. EM radi.masri@gmail.com NR 19 TC 4 Z9 4 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1059-941X J9 J PROSTHODONT JI J. Prosthodont. PD AUG PY 2011 VL 20 IS 6 BP 464 EP 469 DI 10.1111/j.1532-849X.2011.00722.x PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 807PL UT WOS:000293912100007 PM 21777332 ER PT J AU Mancuso, JD Keep, LW AF Mancuso, James D. Keep, Lisa W. TI Deployment-Related Testing and Treatment for Latent Tuberculosis Infection, Part I SO MILITARY MEDICINE LA English DT Article ID GAMMA RELEASE ASSAYS; MYCOBACTERIUM-TUBERCULOSIS; UNITED-STATES; SKIN-TEST; ACTIVE TUBERCULOSIS; T-CELLS; US-ARMY; RISK; DIAGNOSIS; CHILDREN AB Current Topics in Military Tropical Medicine is a Continuing Medical Education series, which updates military medical personnel on questions related to clinical practice while deployed. This issue is Part I of a two-part series on the approach to decision to test, testing and management of latent tuberculosis infection. A representative case is explored in both parts to highlight how to approach service members and their units with regards to latent tuberculosis infection screening and intervention. C1 [Mancuso, James D.; Keep, Lisa W.] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. FU Navy Medicine Manpower Personnel Training and Education Command (NAVMED MPTE); Accreditation Council for Continuing Medical Education (ACCME) FX The series Current Topics in Military Tropical Medicine is an educational outreach program developed by the faculty of U.S. Military Tropical Medicine (MTM) and Military Medicine. MTM conducts education and training sessions for Department of Defense medical personnel who work in developing areas. MTM is a tri-service program conducted under the auspices of the Navy Medicine Manpower Personnel Training and Education Command (NAVMED MPT&E). Questions and comments on this series should be directed to Program Director, U.S. Military Tropical Medicine: Director.MTM@med.navy.mil.; As a sponsor accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of Navy Medicine Manpower Personnel, Training, and Education (NM MPT&E) Command to require the disclosure of the existence of any significant financial interest or any other relationships a faculty member or a sponsor has with the manufacturer(s) or any commercial product(s) discussed in an educational presentation, and also to disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). NM MPT&E Command has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure is available from the Series Editor. In this issue, the authors reported that they had no disclosures. NR 52 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 865 EP 869 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800004 PM 21882774 ER PT J AU Capaldi, VF Guerrero, ML Killgore, WDS AF Capaldi, Vincent F., II Guerrero, Melanie L. Killgore, William D. S. TI Sleep Disruptors Among Returning Combat Veterans From Iraq and Afghanistan SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; AIRWAY-RESISTANCE SYNDROME; POOR SLEEP; DAYTIME SLEEPINESS; SYMPTOMS; PTSD; DISTURBANCE; PREVALENCE; INSOMNIA AB Background: Post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common injuries among returning combat veterans from the wars in Iraq and Afghanistan. Although these combat injuries have been associated with increased sleep disruption, little is known about the nature and specificity of sleep problems within these common injury categories. Method: A retrospective chart review of 69 consecutive referrals to the Walter Reed Army Medical Center sleep clinic was conducted. All cases were active duty soldiers who had recently returned from combat deployment in Iraq or Afghanistan. Data from polysomnographically (PSG) recorded sleep stages, sleepiness scales, and documented medical diagnoses were extracted from medical records. Sleep data were compared across diagnoses of PTSD, TBI, and other clinical conditions. Results: As expected, clinical sleep disturbances, including rates of obstructive sleep apnea, excessive awakenings, daytime sleepiness, and hypoxia, were high for the sample as a whole. However, no differences across diagnostic groups were found. Differences were observed, however, on PSG measures of sleep quality, suggesting more frequent arousals from sleep among patients with PTSD and greater slow wave sleep among those with TBI. Except for REM latency, medication status had virtually no effect on sleep variables. Conclusions: Among recently redeployed combat veterans, clinically significant sleep disturbances and problems with sleep-disordered breathing are common but nonspecific findings across primary diagnoses of PTSD, TBI, major depression, and anxiety disorder, whereas more subtle differences in sleep architecture and arousals as measured by overnight PSG recordings were modestly, but significantly, effective at distinguishing among the diagnostic groups. C1 [Capaldi, Vincent F., II] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Guerrero, Melanie L.; Killgore, William D. S.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Killgore, William D. S.] Harvard Univ, Sch Med, McLean Hosp, Belmont, MA 02478 USA. RP Capaldi, VF (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. RI Schueter, nicos/A-3625-2014 NR 44 TC 41 Z9 41 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 879 EP 888 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800007 PM 21882777 ER PT J AU Roy, TC AF Roy, Tanja C. TI Diagnoses and Mechanisms of Musculoskeletal Injuries in an Infantry Brigade Combat Team Deployed to Afghanistan Evaluated by the Brigade Physical Therapist SO MILITARY MEDICINE LA English DT Article ID OPERATION IRAQI FREEDOM; ENDURING FREEDOM; RISK-FACTORS; EARLY INTERVENTION; OUTPATIENT VISITS; NONBATTLE INJURY; SOLDIERS; PAIN; SURVEILLANCE; EXERCISE AB Musculoskeletal injuries are the most common cause for disability in deployed environments. Current research is limited to body region affected by the injury. Objective: To determine the prevalence of musculoskeletal diagnoses and mechanisms of injury (MOI) as well as associations to specific Military Occupational Specialties (MOS) in a deployed Brigade Combat Team (BCT). Methods: Data collected on 3,066 patient encounters by the Brigade Combat Team physical therapist over 15 months were analyzed using descriptive statistics and chi(2) tests. Results: Mechanical low back pain was the most common diagnosis (19%), whereas overuse was the most prevalent MOI (22%). The Infantry MOS was significantly associated with meniscal tears and pre-existing injuries, the Maintenance MOS with contusions, Signal and Transportation MOSs with weight lifting injuries, and the Administrative MOS with running injuries. Conclusion: Different MOSs are preferentially susceptible to different diagnoses and MOIs. Therefore, different injury prevention strategies may be needed across occupations. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Roy, TC (reprint author), USA, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. FU U.S. Army Research Institute of Environmental Medicine under Task Area S. FX Funding was supplied by the U.S. Army Research Institute of Environmental Medicine under Task Area S. NR 24 TC 15 Z9 15 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 903 EP 908 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800010 PM 21882780 ER PT J AU Gubata, ME Cowan, DN Bedno, SA Urban, N Niebuhr, DW AF Gubata, Marlene E. Cowan, David N. Bedno, Sheryl A. Urban, Nadia Niebuhr, David W. TI Self-Reported Physical Activity and Preaccession Fitness Testing in US Army Applicants SO MILITARY MEDICINE LA English DT Article ID CARDIOVASCULAR EVENTS; BODY-COMPOSITION; WOMEN; PREDICTORS; ATTRITION; MORTALITY; RECRUITS; PREVENTION; EXERCISE; INJURIES AB The Assessment of Recruit Motivation and Strength (ARMS) study evaluated a physical fitness screening test for Army applicants before basic training. This report examines applicants' self-reported physical activity as a predictor of objective fitness measured by ARMS. In 2006, the ARMS study administered a fitness test and physical activity survey to Army applicants during their medical evaluation, using multiple logistic regression for comparison. Among both men and women, "qualified" and "exceeds-body-fat" subjects who met American College of Sports Medicine adult physical activity guidelines were more likely to pass the fitness test. Overall, subjects who met physical activity recommendations, watched less television, and played on sports teams had a higher odds of passing the ARMS test after adjustment for age, race, and smoking status. This study demonstrates that self-reported physical activity was associated with physical fitness and may be used to identify those at risk of failing a preaccession fitness test. C1 [Gubata, Marlene E.; Cowan, David N.; Urban, Nadia; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD 20910 USA. [Cowan, David N.; Urban, Nadia] Allied Technol Grp Inc, Rockville, MD 20850 USA. [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Occupat Hlth Clin, Ft Gordon, GA 30905 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. FU US Army Accession Command FX The authors are grateful for Accession Medical Standards Analysis & Research Activity (AMSARA) staff, especially Ms. Janice Gary for her administrative support. This study was funded by the US Army Accession Command. NR 17 TC 8 Z9 8 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 922 EP 925 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800013 PM 21882783 ER PT J AU Kwolek, LA Berry-Caban, CS Thomas, SF AF Kwolek, Laurie A. Berry-Caban, Cristobal S. Thomas, Sean F. TI Pregnant Soldiers' Participation in Physical Training: A Descriptive Study SO MILITARY MEDICINE LA English DT Article ID EXERCISE AB This study identifies factors that influence U.S. Army soldiers' participation in the Pregnant Soldiers Wellness Program (PSWP), an exercise and wellness education program for soldiers who are either pregnant or in the postpartum period. A retrospective survey was administered prior to initial postpartum hospital discharge. Seventy-four soldiers who delivered babies at Womack Army Medical Center participated in this study. Of those surveyed, 66.2% of respondents participated in the PSWP, 59.5% were encouraged to participate by their provider. Few participants stated that the overall safety, structure, and quality of the PSWP were important factors contributing to their participation. Additionally, less than 20% reported that instructor's knowledge influenced their decision to participate in the PSWP. Most soldiers participated in the program for the health of their fetus and to quickly return to required Army weight standards. This study offers insights that will potentially increase the overall soldier participation rate in the PSWP, thus promoting greater health benefits for the pregnant soldier and increasing sustainment of force readiness. C1 [Kwolek, Laurie A.; Berry-Caban, Cristobal S.; Thomas, Sean F.] Womack Army Med Ctr, Ft Bragg, NC 28301 USA. RP Kwolek, LA (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28301 USA. NR 16 TC 2 Z9 2 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 926 EP 931 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800014 PM 21882784 ER PT J AU Allan, PF Osborn, EC Bloom, BB Wanek, S Cannon, JW AF Allan, Patrick F. Osborn, Erik C. Bloom, Brian B. Wanek, Sandra Cannon, Jeremy W. TI The Introduction of Extracorporeal Membrane Oxygenation to Aeromedical Evacuation SO MILITARY MEDICINE LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; A(H1N1) SUFFICIENT EVIDENCE; END-EXPIRATORY PRESSURE; CARE AIR TRANSPORT; LIFE-SUPPORT; MILITARY MEDICINE; CLINICAL-TRIAL; TIDAL VOLUMES; FAILURE AB Objective: To review the principles of extracorporeal membrane oxygenation (ECMO) and to describe the recent advancements in ECMO technology that permit use of this rescue therapy for severe lung injury in combat casualties. Methods/Results: Lung protective ventilation has defined the state-of-the-art treatment for acute lung injury for more than a decade. Despite the benefits provided by a low tidal volume strategy, lung injury patients may experience deterioration in gas exchange to the point that other rescue interventions are needed or the patient succumbs to progressive respiratory failure. When this occurs in combat casualties, management of the patient in an austere environment and movement to definitive care become problematic. Recent advances in ECMO technology permit long-range transport of these critically ill casualties with greater physiologic reserve and potentially less mortality. Conclusions: Advances in ECMO technology now enable the stabilization and aeromedical evacuation of even the most critically ill combat casualties with severe lung injury. C1 [Allan, Patrick F.; Bloom, Brian B.] Wright Patterson Med Ctr, Dept Pulm Crit Care & Sleep Med, Wright Patterson AFB, OH 45433 USA. [Osborn, Erik C.; Wanek, Sandra] Landstuhl Reg Med Ctr, Dept Surg & Crit Care, APO, AE 09180 USA. [Cannon, Jeremy W.] Brooke Army Med Ctr, Dept Surg, Div Trauma & Acute Care Surg, Ft Sam Houston, TX 78234 USA. RP Allan, PF (reprint author), Wright Patterson Med Ctr, Dept Pulm Crit Care & Sleep Med, 4881 Sugar Maple Dr, Wright Patterson AFB, OH 45433 USA. FU Defense Medical Research and Development Program FX JWC is supported by a grant from the Defense Medical Research and Development Program. NR 43 TC 3 Z9 3 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 932 EP 937 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800015 PM 21882785 ER PT J AU Huh, J Posner, MA Bear, RR Banerjee, R Owens, BD Hsu, JR AF Huh, Jeannie Posner, Matthew A. Bear, Russell R. Banerjee, Rahul Owens, Brett D. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Performance of Military Tasks After Clavicle Plating SO MILITARY MEDICINE LA English DT Article ID MIDCLAVICULAR FRACTURES; NONOPERATIVE TREATMENT; UPPER EXTREMITY; FIXATION; COMPLICATIONS; EPIDEMIOLOGY AB Management of displaced midshaft clavicle fractures in the military, a largely shoulder-bearing population, is controversial. We aimed to report the military-relevant functional outcomes after plate fixation. We performed a nested cross-sectional analysis of active duty service members enrolled in an ongoing multicenter, randomized trial on clavicle plating. For this analysis, we included subjects with >= 6 months follow-up. Outcome measures included radiographic appearance, physical examination, a military-specific questionnaire, and validated shoulder surveys. Mean follow-up for 28 clavicle fractures was 13 months. Union rate by 12 weeks was 93% (26/28). There was one case of soft tissue irritation requiring hardware removal. At latest follow-up, 75% of patients were satisfied; 68% had mild/no pain; 79% had full range of motion; 75% could perform push-ups; and 21% have deployed. For the majority of active duty personnel, rapid healing, return to military-specific tasks, and satisfaction with outcome are possible after plate fixation of clavicle fractures. However, approximately 25% report some functional limitations at 1 year. C1 [Huh, Jeannie] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Posner, Matthew A.; Bear, Russell R.] William Beaumont Med Ctr, El Paso, TX 79920 USA. [Banerjee, Rahul] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Owens, Brett D.] Keller Army Community Hosp, West Point, NY 10996 USA. [Hsu, Joseph R.; Skeletal Trauma Res Consortium] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Huh, J (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU United States Army Institute of Surgical Research; The Geneva Foundation FX The authors acknowledge Patient Administration Systems and Biostatistics Activity for providing data for this study. This study was funded by the United States Army Institute of Surgical Research. There are no personal disclosures. Institutional research support came from The Geneva Foundation. NR 32 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 950 EP 955 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800019 PM 21882789 ER PT J AU Schlussel, AT Yheulon, CG Gagliano, RA AF Schlussel, Andrew T. Yheulon, Christopher G. Gagliano, Ronald A. TI Negative-Pressure Pulmonary Edema Following a Lateral Internal Sphincterotomy SO MILITARY MEDICINE LA English DT Article AB Negative-pressure pulmonary edema (NPPE) is an infrequent but known postoperative complication following endotracheal intubation and general anesthesia. We report a case of a healthy 24-year-old man requiring intensive care unit management for NPPE following a routine surgical procedure. This article discusses how rare but serious the complication of NPPE can be; it also describes the diagnosis, evaluation, and treatment from one institution's experience. C1 [Schlussel, Andrew T.; Yheulon, Christopher G.; Gagliano, Ronald A.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. RP Schlussel, AT (reprint author), Tripler Army Med Ctr, Dept Gen Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 8 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2011 VL 176 IS 8 BP 964 EP 965 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 804TB UT WOS:000293675800022 PM 21882792 ER PT J AU Dietrich, JC Westerink, JJ Kennedy, AB Smith, JM Jensen, RE Zijlema, M Holthuijsen, LH Dawson, C Luettich, RA Powell, MD Cardone, VJ Cox, AT Stone, GW Pourtaheri, H Hope, ME Tanaka, S Westerink, LG Westerink, HJ Cobell, Z AF Dietrich, J. C. Westerink, J. J. Kennedy, A. B. Smith, J. M. Jensen, R. E. Zijlema, M. Holthuijsen, L. H. Dawson, C. Luettich, R. A., Jr. Powell, M. D. Cardone, V. J. Cox, A. T. Stone, G. W. Pourtaheri, H. Hope, M. E. Tanaka, S. Westerink, L. G. Westerink, H. J. Cobell, Z. TI Hurricane Gustav (2008) Waves and Storm Surge: Hindcast, Synoptic Analysis, and Validation in Southern Louisiana SO MONTHLY WEATHER REVIEW LA English DT Article ID COASTAL REGIONS; WIND FIELDS; MODEL; COMPUTATIONS; ENERGY; SCALE; SWAN AB Hurricane Gustav (2008) made landfall in southern Louisiana on 1 September 2008 with its eye never closer than 75 km to New Orleans, but its waves and storm surge threatened to flood the city. Easterly tropical-storm-strength winds impacted the region east of the Mississippi River for 12-15 h, allowing for early surge to develop up to 3.5 m there and enter the river and the city's navigation canals. During landfall, winds shifted from easterly to southerly, resulting in late surge development and propagation over more than 70 km of marshes on the river's west bank, over more than 40 km of Caernarvon marsh on the east bank, and into Lake Pontchartrain to the north. Wind waves with estimated significant heights of 15 m developed in the deep Gulf of Mexico but were reduced in size once they reached the continental shelf. The barrier islands further dissipated the waves, and locally generated seas existed behind these effective breaking zones. The hardening and innovative deployment of gauges since Hurricane Katrina (2005) resulted in a wealth of measured data for Gustav. A total of 39 wind wave time histories, 362 water level time histories, and 82 high water marks were available to describe the event. Computational models-including a structured-mesh deepwater wave model (WAM) and a nearshore steady-state wave (STWAVE) model, as well as an unstructured-mesh "simulating waves nearshore'' (SWAN) wave model and an advanced circulation (ADCIRC) model-resolve the region with unprecedented levels of detail, with an unstructured mesh spacing of 100-200 m in the wave-breaking zones and 20-50 m in the small-scale channels. Data-assimilated winds were applied using NOAA's Hurricane Research Division Wind Analysis System (H*Wind) and Interactive Objective Kinematic Analysis (IOKA) procedures. Wave and surge computations from these models are validated comprehensively at the measurement locations ranging from the deep Gulf of Mexico and along the coast to the rivers and floodplains of southern Louisiana and are described and quantified within the context of the evolution of the storm. C1 [Dietrich, J. C.; Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Dietrich, J. C.; Westerink, J. J.; Kennedy, A. B.; Hope, M. E.; Tanaka, S.; Westerink, L. G.; Westerink, H. J.; Cobell, Z.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Smith, J. M.; Jensen, R. E.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Zijlema, M.; Holthuijsen, L. H.] Delft Univ Technol, Fac Civil Engn & Geosci, Delft, Netherlands. [Luettich, R. A., Jr.] Univ N Carolina Chapel Hill, Inst Marine Sci, Morehead City, NC USA. [Powell, M. D.] NOAA, Atlantic Oceanog & Meteorol Lab, Hurricane Res Div, Miami, FL 33149 USA. [Cardone, V. J.; Cox, A. T.] Oceanweather Inc, Cos Cob, CT USA. [Stone, G. W.] Louisiana State Univ, Inst Coastal Studies, Baton Rouge, LA 70803 USA. [Pourtaheri, H.] US Army Corps Engineers, New Orleans, LA USA. RP Dietrich, JC (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, 1 Univ Stn,C0200, Austin, TX 78712 USA. EM dietrich@ices.utexas.edu RI Dietrich, Joel/E-5161-2011; Kennedy, Andrew/E-4746-2011; Powell, Mark/I-4963-2013; Zijlema, Marcel/J-3099-2013 OI Dietrich, Joel/0000-0001-5294-2874; Kennedy, Andrew/0000-0002-7254-1346; Powell, Mark/0000-0002-4890-8945; FU U.S. Army Corps of Engineers (USACE) New Orleans District; Federal Emergency Management Agency Region 6; U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center; University of Texas at Austin, Texas Advanced Computing Center; National Science Foundation [OCI-0746232]; Office of Naval Research [N00014-06-1-0285]; U.S. Army Corps of Engineers; U.S. Department of Homeland Security [2008-ST-061-ND0001] FX This work was supported by the U.S. Army Corps of Engineers (USACE) New Orleans District and the Federal Emergency Management Agency Region 6. Computational resources and support were provided by the U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center and the University of Texas at Austin, Texas Advanced Computing Center. Awards from the National Science Foundation (OCI-0746232) and the Office of Naval Research (N00014-06-1-0285) supported ADCIRC and SWAN model development. Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corps of Engineers. This material is based upon work supported by the U.S. Department of Homeland Security under Award 2008-ST-061-ND0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Homeland Security. NR 52 TC 47 Z9 47 U1 3 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0027-0644 J9 MON WEATHER REV JI Mon. Weather Rev. PD AUG PY 2011 VL 139 IS 8 BP 2488 EP 2522 DI 10.1175/2011MWR3611.1 PG 35 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 806RY UT WOS:000293829600011 ER PT J AU Cardile, AP Forbes, D Cirigliano, V Stout, B Das, NP Hsue, G AF Cardile, A. P. Forbes, D. Cirigliano, V. Stout, B. Das, N. P. Hsue, G. TI Hafnia alvei pyelonephritis in a renal transplant recipient: case report and review of an under-recognized nosocomial pathogen SO TRANSPLANT INFECTIOUS DISEASE LA English DT Review DE Hafnia alvei; renal transplant recipient; pyelonephritis ID INFECTION AB We describe the first case to our knowledge of Hafnia alvei pyelonephritis in a renal transplant recipient. Clinicians should consider this under-recognized pathogen when clinically evaluating immunosuppressed patients with a history of invasive procedures. C1 [Hsue, G.] Tripler Army Med Ctr, Dept Infect Dis, Honolulu, HI 96859 USA. [Cardile, A. P.; Forbes, D.; Cirigliano, V.; Stout, B.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. [Das, N. P.] Tripler Army Med Ctr, Dept Nephrol, Honolulu, HI 96859 USA. RP Hsue, G (reprint author), Tripler Army Med Ctr, Dept Infect Dis, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM gunther.hsue@us.army.mil NR 13 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1398-2273 J9 TRANSPL INFECT DIS JI Transpl. Infect. Dis. PD AUG PY 2011 VL 13 IS 4 BP 407 EP 410 DI 10.1111/j.1399-3062.2011.00600.x PG 4 WC Immunology; Infectious Diseases; Transplantation SC Immunology; Infectious Diseases; Transplantation GA 804MN UT WOS:000293658000012 PM 21299775 ER PT J AU Hsieh, DT Chang, T AF Hsieh, David T. Chang, Taeun TI Incontinentia Pigmenti Skin and Magnetic Resonance Imaging Findings SO ARCHIVES OF NEUROLOGY LA English DT Editorial Material C1 [Chang, Taeun] Childrens Natl Med Ctr, Dept Neurol, Div Neurophysiol Epilepsy & Neurocrit Care, Washington, DC 20010 USA. [Hsieh, David T.] Brooke Army Med Ctr, Dept Pediat, Div Child Neurol, San Antonio Mil Med Ctr, Houston, TX USA. RP Chang, T (reprint author), Childrens Natl Med Ctr, Dept Neurol, Div Neurophysiol Epilepsy & Neurocrit Care, 111 Michigan Ave NW, Washington, DC 20010 USA. EM tchang@childrensnational.org NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD AUG PY 2011 VL 68 IS 8 BP 1080 EP 1081 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 804IM UT WOS:000293647500022 PM 21825250 ER PT J AU Kahana, A Bohnsack, BL Cho, RI Maher, CO AF Kahana, Alon Bohnsack, Brenda L. Cho, Raymond I. Maher, Cormac O. TI Subtotal Excision With Adjunctive Sclerosing Therapy for the Treatment of Severe Symptomatic Orbital Lymphangiomas SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article ID VASCULAR-LESIONS AB Orbital lymphangiomas are congenital malformations with abnormal and dead-end lymphatic channels and present management challenges to ophthalmologists and orbital surgeons. Recurrent hemorrhage and expansion can lead to vision loss and disfigurement. We report our technique that uses adjunctive intraoperative injection of sodium morrhuate, 5%, under direct visualization into lymphangioma channels prior to excision. We believe that in the hands of experienced orbital surgeons, and with appropriate preoperative evaluation and careful surgical technique, this procedure is useful in saving vision and avoiding complications from orbital lymphangiomas. Arch Ophthalmol. 2011;129(8):1073-1076 C1 [Kahana, Alon; Bohnsack, Brenda L.; Cho, Raymond I.] Univ Michigan, Kellogg Eye Ctr, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48105 USA. [Maher, Cormac O.] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48105 USA. [Cho, Raymond I.] Brooke Army Med Ctr, Ophthalmol Serv, San Antonio, TX USA. RP Kahana, A (reprint author), Univ Michigan, Kellogg Eye Ctr, Dept Ophthalmol & Visual Sci, 1000 Wall St, Ann Arbor, MI 48105 USA. EM akahana@med.umich.edu OI Kahana, Alon/0000-0002-5667-2274 FU NEI NIH HHS [L40 EY019187-01, L40 EY019187-02, K08 EY018689, L40 EY019187] NR 6 TC 4 Z9 4 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD AUG PY 2011 VL 129 IS 8 BP 1073 EP 1076 PG 4 WC Ophthalmology SC Ophthalmology GA 804IZ UT WOS:000293648800015 PM 21825192 ER PT J AU Zainuddin, S Hosur, MV Barua, R Kumar, A Jeelani, S AF Zainuddin, S. Hosur, M. V. Barua, R. Kumar, Ashok Jeelani, S. TI Effects of ultraviolet radiation and condensation on static and dynamic compression behavior of neat and nanoclay infused epoxy/glass composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE glass/epoxy composites; nanoclay; ultraviolet radiation/condensation ID EPOXY-ORGANOCLAY NANOCOMPOSITES; ENVIRONMENTAL DEGRADATION; MECHANICAL-PROPERTIES; COLOR FORMATION; UV EXPOSURE; PHOTODEGRADATION; POLYPROPYLENE; DURABILITY; POLYMERS; STRESSES AB Effects of ultraviolet radiation and condensation on the static and dynamic compressive properties of composites with and without nanoclay were investigated. Specimens were exposed to ultraviolet radiation (UV), and alternate ultraviolet radiation and condensation (UC) conditions for 5, 10, and 15 days, respectively. Compression test results showed an increase in strength and modulus with increase in strain rate and nanoclay weight percent loading. However, properties degraded upon conditioning with nanoclay infused systems showing less degradation. Scanning electron micrographs of fractured samples show better interfacial bonding in nanoclay infused composites in 2 wt. % system showing best properties. C1 [Zainuddin, S.; Hosur, M. V.; Barua, R.; Jeelani, S.] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Kumar, Ashok] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. RP Hosur, MV (reprint author), Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. EM hosur@tuskegee.edu FU U. S. Army Engineer Research Development Center - Construction Engineering Research Laboratory FX Authors would like to thank the support received by U. S. Army Engineer Research Development Center - Construction Engineering Research Laboratory to carry out this work. NR 40 TC 0 Z9 0 U1 1 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD AUG PY 2011 VL 45 IS 18 BP 1901 EP 1918 DI 10.1177/0021998310394693 PG 18 WC Materials Science, Composites SC Materials Science GA 804YB UT WOS:000293690100009 ER PT J AU Proie, RM Polcawich, RG Pulskamp, JS Ivanov, T Zaghloul, ME AF Proie, Robert M., Jr. Polcawich, Ronald G. Pulskamp, Jeffrey S. Ivanov, Tony Zaghloul, Mona E. TI Development of a PZT MEMS Switch Architecture for Low-Power Digital Applications SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Actuators; digital circuits; piezoelectric devices; lead zirconate titanate (PZT) ceramics ID THIN-FILMS; WAVE-FORM; RF MEMS; ELECTRODES; ACTUATION; VOLTAGE AB A lead zirconate titanate (PZT) microelectromechanical systems (MEMS) digital switch was designed as a low-power low-frequency control system intended to create energy-efficient microcontrollers, control higher voltage systems, and provide integrated control over other MEMS platforms. In addition, the technology is inherently insensitive to high energy radiation and has been shown to operate over a wide range of temperatures. Initial devices were fabricated with three design variables of interest-actuator length, width, and contact metallurgy (Au/Pt, Au/Ru, and Au/Au). To assess the impact of each variable on device performance, device wafers were measured using a SUSS semi-automated probe station and associated control hardware and software. Devices were evaluated based on contact resistance, actuation voltage, minimum actuation voltage using a voltage bias, propagation delay, dynamic power, and static power consumption. The measurements were then analyzed to determine the optimal switch geometry and contact material combination for digital applications. With the data collected, a software model was developed for accurate simulation of higher complexity circuits composed of these switches. [2010-0351] C1 [Proie, Robert M., Jr.; Zaghloul, Mona E.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. [Proie, Robert M., Jr.; Polcawich, Ronald G.; Pulskamp, Jeffrey S.; Ivanov, Tony] USA, Res Lab, Adelphi, MD 20783 USA. RP Proie, RM (reprint author), George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. EM robert.proie@us.army.mil; ronald.g.polcawich@us.army.mil; jeffrey.pulskamp1@us.army.mil; tony.ivanov@us.army.mil; zaghloul@gwu.edu FU U.S. Army Research Laboratory; Defense Advanced Research Projects Agency FX Manuscript received December 21, 2010; revised March 9, 2011; accepted March 31, 2011. Date of publication June 16, 2011; date of current version August 3, 2011. This work was supported in part by the U.S. Army Research Laboratory and in part by the Defense Advanced Research Projects Agency Nano-Electromechanical Switches program. Subject Editor R. Ghodssi. NR 20 TC 25 Z9 26 U1 3 U2 28 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD AUG PY 2011 VL 20 IS 4 BP 1032 EP 1042 DI 10.1109/JMEMS.2011.2148160 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 805TE UT WOS:000293751100029 ER PT J AU D'Avignon, LC Chung, KK Saffle, JR Renz, EM Cancio, LC AF D'Avignon, Laurie C. Chung, Kevin K. Saffle, Jeffery R. Renz, Evan M. Cancio, Leopoldo C. CA Prevention Combat-Related Infect TI Prevention of Infections Associated With Combat-Related Burn Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Burns; Thermal injury; Military; Combat; Infection ID 1-PERCENT SILVER SULFADIAZINE; OPERATION IRAQI FREEDOM; WOUND INFECTIONS; ANTIBIOTIC-PROPHYLAXIS; EARLY EXCISION; ACINETOBACTER INFECTION; MAFENIDE ACETATE; COLONIZATION; PSEUDOMONAS; MANIPULATION AB Burns are a very real component of combat-related injuries, and infections are the leading cause of mortality in burn casualties. The prevention of infection in the burn casualty transitioning from the battlefield to definitive care provided at the burn center is critical in reducing overall morbidity and mortality. This review highlights evidence-based medicine recommendations using military and civilian data to provide the most comprehensive, up-to-date management strategies for initial care of burned combat casualties. Areas of emphasis include antimicrobial prophylaxis, debridement of devitalized tissue, topical antimicrobial therapy, and optimal time to wound coverage. This evidence-based medicine review was produced to support the Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update contained in this supplement of Journal of Trauma. C1 [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA. [Chung, Kevin K.; Renz, Evan M.; Cancio, Leopoldo C.] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Saffle, Jeffery R.] Univ Utah, Dept Surg, Salt Lake City, UT USA. RP D'Avignon, LC (reprint author), AFMSA SGXI, Global Hlth Engagement Branch, 2200 Berguist Dr, Lackland AFB, TX 78235 USA. EM laurie.davignon@us.af.mil FU US Army Medical Command FX Supported by the US Army Medical Command for the consensus conference and publication of the Journal of Trauma supplement. NR 75 TC 15 Z9 16 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S282 EP S289 DI 10.1097/TA.0b013e318227adc2 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300008 PM 21814094 ER PT J AU Holcomb, JB Zarzabal, LA Michalek, JE Kozar, RA Spinella, PC Perkins, JG Matijevic, N Dong, JF Pati, S Wade, CE AF Holcomb, John B. Zarzabal, Lee A. Michalek, Joel E. Kozar, Rosemary A. Spinella, Phillip C. Perkins, Jeremy G. Matijevic, Nena Dong, Jing-Fei Pati, Shibani Wade, Charles E. CA Trauma Outcomes Grp TI Increased Platelet:RBC Ratios Are Associated With Improved Survival After Massive Transfusion SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 39th Annual Meeting of the Western-Trauma-Association CY FEB 22-28, 2009 CL Crested Butte, CO SP Western Trauma Assoc DE Platelets; Injury; Massive transfusion ID FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; I TRAUMA CENTER; RED-BLOOD-CELL; EARLY COAGULOPATHY; HEMORRHAGIC-SHOCK; BLEEDING PATIENTS; COMBAT CASUALTIES; ORGAN FAILURE; MORTALITY AB Background: Several recent military and civilian trauma studies demonstrate that improved outcomes are associated with early and increased use of plasma-based resuscitation strategies. However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT). Methods: A transfusion database of patients transported from the scene to 22 Level I Trauma Centers over 12 months in 2005 to 2006 was reviewed. MT was defined as receiving >= 10 RBC units within 24 hours of admission. To mitigate survival bias, 25 patients who died within 60 minutes of arrival were excluded from analysis. Six random donor platelet units were considered equal to a single apheresis platelet unit. Admission and outcome data associated with the low (> 1:20), medium (1:2), and high (1:1) platelet:RBC ratios were examined. These groups were based on the median value of the tertiles for the ratio of platelets:RBC units. Results: Two thousand three hundred twelve patients received at least one unit of blood and 643 received an MT. Admission vital signs, INR, temperature, pH, Glasgow Coma Scale, Injury Severity Score, and age were similar between platelet ratio groups. The average admission platelet counts were lower in the patients who received the high platelet:RBC ratio versus the low ratio (192 vs. 216, p = 0.03). Patients who received MT were severely injured, with a mean (+/- standard deviation) Injury Severity Score of 33 +/- 16 and received 22 +/- 15 RBCs and 11 +/- 14 platelets within 24 hours of injury. Increased platelet ratios were associated with improved survival at 24 hours and 30 days (p < 0.001 for both). Truncal hemorrhage as a cause of death was decreased (low: 67%, medium: 60%, high: 47%, p = 0.04). Multiple organ failure mortality was increased (low: 7%, medium: 16%, high: 27%, p = 0.003), but overall 30-day survival was improved (low: 52%, medium: 57%, high: 70%) in the high ratio group (medium vs. high: p = 0.008; low vs. high: p = 0.007). Conclusion: Similar to recently published military data, transfusion of platelet:RBC ratios of 1:1 was associated with improved early and late survival, decreased hemorrhagic death and a concomitant increase in multiple organ failure-related mortality. Based on this large retrospective study, increased and early use of platelets may be justified, pending the results of prospective randomized transfusion data. C1 [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. [Zarzabal, Lee A.; Michalek, Joel E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Spinella, Phillip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Perkins, Jeremy G.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Dong, Jing-Fei] Baylor Coll Med, Houston, TX 77030 USA. [Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Holcomb, JB (reprint author), Univ Texas Hlth Sci Ctr, Div Acute Care Surg, Ctr Translat Injury Res, 6410 Fannin Suite 1100, Houston, TX 77030 USA. EM john.holcomb@uth.tmc.edu NR 103 TC 74 Z9 76 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 3 BP S318 EP S328 DI 10.1097/TA.0b013e318227edbb PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XE UT WOS:000293849700002 PM 21814099 ER PT J AU Holcomb, JB Wade, CE AF Holcomb, John B. Wade, Charles E. CA Trauma Outcomes Grp TI Defining Present Blood Component Transfusion Practices in Trauma Patients: Papers From the Trauma Outcomes Group SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; 753 CONSECUTIVE DEATHS; MASSIVE TRANSFUSION; AGGRESSIVE USE; EMERGENCY-DEPARTMENT; PLATELET TRANSFUSION; INJURY PREVENTION; IMPROVED SURVIVAL; PRODUCT RATIO C1 [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX USA. [Holcomb, John B.; Wade, Charles E.] USA, Inst Res, Ft Sam Houston, TX USA. RP Wade, CE (reprint author), 6431 Fannin,MSB 5-204, Houston, TX 77030 USA. EM charles.e.wade@uth.tmc.edu FU Department of Defense (DoD) [W81XWH-07-1-0717] FX Supported, in part, by the Department of Defense (DoD) grant W81XWH-07-1-0717. NR 48 TC 10 Z9 10 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 3 BP S315 EP S317 DI 10.1097/TA.0b013e318227ed13 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XE UT WOS:000293849700001 PM 21814098 ER PT J AU Hospenthal, DR Murray, CK Andersen, RC Bell, RB Calhoun, JH Cancio, LC Cho, JM Chung, KK Clasper, JC Colyer, MH Conger, NG Costanzo, GP Crouch, HK Curry, TK D'Avignon, LC Dorlac, WC Dunne, JR Eastridge, BJ Ficke, JR Fleming, ME Forgione, MA Green, AD Hale, RG Hayes, DK Holcomb, JB Hsu, JR Kester, KE Martin, GJ Moores, LE Obremskey, WT Petersen, K Renz, EM Saffle, JR Solomkin, JS Sutter, DE Tribble, DR Wenke, JC Whitman, TJ Wiesen, AR Wortmann, GW AF Hospenthal, Duane R. Murray, Clinton K. Andersen, Romney C. Bell, R. Bryan Calhoun, Jason H. Cancio, Leopoldo C. Cho, John M. Chung, Kevin K. Clasper, Jon C. Colyer, Marcus H. Conger, Nicholas G. Costanzo, George P. Crouch, Helen K. Curry, Thomas K. D'Avignon, Laurie C. Dorlac, Warren C. Dunne, James R. Eastridge, Brian J. Ficke, James R. Fleming, Mark E. Forgione, Michael A. Green, Andrew D. Hale, Robert G. Hayes, David K. Holcomb, John B. Hsu, Joseph R. Kester, Kent E. Martin, Gregory J. Moores, Leon E. Obremskey, William T. Petersen, Kyle Renz, Evan M. Saffle, Jeffrey R. Solomkin, Joseph S. Sutter, Deena E. Tribble, David R. Wenke, Joseph C. Whitman, Timothy J. Wiesen, Andrew R. Wortmann, Glenn W. TI Executive Summary: Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update Endorsed by the Infectious Diseases Society of America and the Surgical Infection Society SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Guidelines; Infection; Combat; Trauma; Prevention AB Despite advances in resuscitation and surgical management of combat wounds, infection remains a concerning and potentially preventable complication of combat-related injuries. Interventions currently used to prevent these infections have not been either clearly defined or subjected to rigorous clinical trials. Current infection prevention measures and wound management practices are derived from retrospective review of wartime experiences, from civilian trauma data, and from in vitro and animal data. This update to the guidelines published in 2008 incorporates evidence that has become available since 2007. These guidelines focus on care provided within hours to days of injury, chiefly within the combat zone, to those combat-injured patients with open wounds or burns. New in this update are a consolidation of antimicrobial agent recommendations to a backbone of high-dose cefazolin with or without metronidazole for most postinjury indications and recommendations for redosing of antimicrobial agents, for use of negative pressure wound therapy, and for oxygen supplementation in flight. C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA. [Cancio, Leopoldo C.; Chung, Kevin K.; Costanzo, George P.; Eastridge, Brian J.; Hale, Robert G.; Hsu, Joseph R.; Renz, Evan M.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Andersen, Romney C.; Colyer, Marcus H.; Dunne, James R.; Fleming, Mark E.; Martin, Gregory J.; Whitman, Timothy J.; Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA. [Tribble, David R.] Infect Dis Clin Res Program, Bethesda, MD USA. [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA. [Cho, John M.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Clasper, Jon C.; Green, Andrew D.] Royal Ctr Def Med, Inst Res & Dev, Birmingham, W Midlands, England. [Conger, Nicholas G.; Forgione, Michael A.] Keesler Med Ctr, Keesler AFB, MS USA. [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA. [Wiesen, Andrew R.] Western Reg Med Command, Ft Lewis, WA USA. [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA. [Dorlac, Warren C.; Solomkin, Joseph S.] Univ Cincinnati, Cincinnati, OH USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Kester, Kent E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Moores, Leon E.] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA. [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA. [Saffle, Jeffrey R.] Univ Utah, Salt Lake City, UT USA. RP Hospenthal, DR (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@us.army.mil FU US Army Medical Command FX Financial support for the consensus conference and publication of the Journal of Trauma supplement was provided by the US Army Medical Command. NR 6 TC 5 Z9 5 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S202 EP S209 DI 10.1097/TA.0b013e318227ac37 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300002 PM 21814088 ER PT J AU Hospenthal, DR Murray, CK Andersen, RC Bell, RB Calhoun, JH Cancio, LC Cho, JM Chung, KK Clasper, JC Colyer, MH Conger, NG Costanzo, GP Crouch, HK Curry, TK D'Avignon, LC Dorlac, WC Dunne, JR Eastridge, BJ Ficke, JR Fleming, ME Forgione, MA Green, AD Hale, RG Hayes, DK Holcomb, JB Hsu, JR Kester, KE Martin, GJ Moores, LE Obremskey, WT Petersen, K Renz, EM Saffle, JR Solomkin, JS Sutter, DE Tribble, DR Wenke, JC Whitman, TJ Wiesen, AR Wortmann, GW AF Hospenthal, Duane R. Murray, Clinton K. Andersen, Romney C. Bell, R. Bryan Calhoun, Jason H. Cancio, Leopoldo C. Cho, John M. Chung, Kevin K. Clasper, Jon C. Colyer, Marcus H. Conger, Nicholas G. Costanzo, George P. Crouch, Helen K. Curry, Thomas K. D'Avignon, Laurie C. Dorlac, Warren C. Dunne, James R. Eastridge, Brian J. Ficke, James R. Fleming, Mark E. Forgione, Michael A. Green, Andrew D. Hale, Robert G. Hayes, David K. Holcomb, John B. Hsu, Joseph R. Kester, Kent E. Martin, Gregory J. Moores, Leon E. Obremskey, William T. Petersen, Kyle Renz, Evan M. Saffle, Jeffrey R. Solomkin, Joseph S. Sutter, Deena E. Tribble, David R. Wenke, Joseph C. Whitman, Timothy J. Wiesen, Andrew R. Wortmann, Glenn W. TI Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update Endorsed by the Infectious Diseases Society of America and the Surgical Infection Society SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Guidelines; Infection; Combat; Trauma; Prevention ID OPERATION-IRAQI-FREEDOM; HYPERBARIC-OXYGEN THERAPY; SMALL-FRAGMENT WOUNDS; PENETRATING CRANIOCEREBRAL INJURIES; RANDOMIZED CLINICAL-TRIAL; INTRAOPERATIVE BLOOD-LOSS; VACUUM-ASSISTED CLOSURE; SEVERE OPEN FRACTURES; OPEN TIBIA FRACTURES; COMPLICATED INTRAABDOMINAL INFECTIONS AB Despite advances in resuscitation and surgical management of combat wounds, infection remains a concerning and potentially preventable complication of combat-related injuries. Interventions currently used to prevent these infections have not been either clearly defined or subjected to rigorous clinical trials. Current infection prevention measures and wound management practices are derived from retrospective review of wartime experiences, from civilian trauma data, and from in vitro and animal data. This update to the guidelines published in 2008 incorporates evidence that has become available since 2007. These guidelines focus on care provided within hours to days of injury, chiefly within the combat zone, to those combat-injured patients with open wounds or burns. New in this update are a consolidation of antimicrobial agent recommendations to a backbone of high-dose cefazolin with or without metronidazole for most postinjury indications, and recommendations for redosing of antimicrobial agents, for use of negative pressure wound therapy, and for oxygen supplementation in flight. C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA. [Cancio, Leopoldo C.; Chung, Kevin K.; Costanzo, George P.; Eastridge, Brian J.; Hale, Robert G.; Hsu, Joseph R.; Renz, Evan M.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Andersen, Romney C.; Colyer, Marcus H.; Dunne, James R.; Fleming, Mark E.; Martin, Gregory J.; Whitman, Timothy J.; Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA. [Tribble, David R.] Infect Dis Clin Res Program, Bethesda, MD USA. [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA. [Cho, John M.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Clasper, Jon C.; Green, Andrew D.] Royal Ctr Def Med, Inst Res & Dev, Birmingham, W Midlands, England. [Conger, Nicholas G.; Forgione, Michael A.] Keesler Med Ctr, Keesler AFB, MS USA. [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA. [Wiesen, Andrew R.] Western Reg Med Command, Ft Lewis, WA USA. [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA. [Dorlac, Warren C.; Solomkin, Joseph S.] Univ Cincinnati, Cincinnati, OH USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Kester, Kent E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Moores, Leon E.] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA. [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA. [Saffle, Jeffrey R.] Univ Utah, Salt Lake City, UT USA. RP Hospenthal, DR (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@us.army.mil FU US Army Medical Command FX Financial support for the consensus conference and publication of the Journal of Trauma supplement was provided by the US Army Medical Command. NR 291 TC 32 Z9 35 U1 1 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S210 EP S234 DI 10.1097/TA.0b013e318227ac4b PG 25 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300003 PM 21814089 ER PT J AU Murray, CK Obremskey, WT Hsu, JR Andersen, RC Calhoun, JH Clasper, JC Whitman, TJ Curry, TK Fleming, ME Wenke, JC Ficke, JR AF Murray, Clinton K. Obremskey, William T. Hsu, Joseph R. Andersen, Romney C. Calhoun, Jason H. Clasper, Jon C. Whitman, Timothy J. Curry, Thomas K. Fleming, Mark E. Wenke, Joseph C. Ficke, James R. CA Prevention Combat-Related Infect TI Prevention of Infections Associated With Combat-Related Extremity Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Extremity; Infection; Prevention; Iraq; Afghanistan ID OPERATION-IRAQI-FREEDOM; OPEN TIBIAL FRACTURES; PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN THERAPY; INTRAOPERATIVE BLOOD-LOSS; SMALL-FRAGMENT WOUNDS; RESISTANT STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED CLOSURE; KOREAN BATTLE CASUALTY; SUPPLEMENTAL PERIOPERATIVE OXYGEN AB During combat operations, extremities continue to be the most common sites of injury with associated high rates of infectious complications. Overall, similar to 15% of patients with extremity injuries develop osteomyelitis, and similar to 17% of those infections relapse or recur. The bacteria infecting these wounds have included multidrug-resistant bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Klebsiella species and Escherichia coli, and methicillin-resistant Staphylococcus aureus. The goals of extremity injury care are to prevent infection, promote fracture healing, and restore function. In this review, we use a systematic assessment of military and civilian extremity trauma data to provide evidence-based recommendations for the varying management strategies to care for combat-related extremity injuries to decrease infection rates. We emphasize postinjury antimicrobial therapy, debridement and irrigation, and surgical wound management including addressing ongoing areas of controversy and needed research. In addition, we address adjuvants that are increasingly being examined, including local antimicrobial therapy, flap closure, oxygen therapy, negative pressure wound therapy, and wound effluent characterization. This evidence-based medicine review was produced to support the Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update contained in this supplement of Journal of Trauma. C1 [Murray, Clinton K.; Hsu, Joseph R.; Ficke, James R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hsu, Joseph R.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Andersen, Romney C.; Whitman, Timothy J.; Fleming, Mark E.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA. [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA. [Clasper, Jon C.] Royal Coll Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@us.army.mil FU US Army Medical Command FX Financial support for the consensus conference and publication of the Journal of Trauma supplement was provided by the US Army Medical Command. NR 308 TC 44 Z9 47 U1 0 U2 32 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S235 EP S257 DI 10.1097/TA.0b013e318227ac5f PG 23 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300004 PM 21814090 ER PT J AU Murray, CK Hospenthal, DR Kotwal, RS Butler, FK AF Murray, Clinton K. Hospenthal, Duane R. Kotwal, Russ S. Butler, Frank K. TI Efficacy of Point-of-Injury Combat Antimicrobials SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat; Trauma; Infection; Antimicrobial; Prevention ID OPEN TIBIAL FRACTURES; WAR WOUNDS; INFECTIOUS COMPLICATIONS; ENDURING-FREEDOM; ANTIBIOTIC-PROPHYLAXIS; EXTREMITY INJURIES; OPERATIONS IRAQI; CARE; MILITARY; TIME AB Background: Infection is a major complication associated with combat-related injuries. One strategy to decrease infections is immediate delivery of antimicrobials at or near the point-of-injury by the casualty or the first medical responder. The 75th Ranger Regiment systematically collects data on prehospital battlefield care, including antimicrobial administration. We review infectious complications and colonization rates associated with delivery of point-of-injury antimicrobial therapy. Methods: We retrospectively reviewed casualty treatment data from the 75th Ranger Regiment prehospital trauma registry on patients injured between March 2003 and March 2010 and linked this to electronic medical record data to look for the presence of bacterial infection or colonization within 30 days of injury. Patient demographics, antimicrobial therapy, and outcomes were evaluated. Assessment of colonization included surveillance screening cultures performed for multidrug-resistant bacteria, including Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus, at US military hospitals in the combat zone, Germany, and stateside. Results: Of 405 total casualties, 28 (6.9%) were infected with gram-negative bacteria, primarily A. baumannii. Of those who were not returned to duty or died near the time of injury, 28 of 211 (13.3%) were infected. The only identified risk factor for infection was higher military Injury Severity Score. Prehospital administration of antimicrobials to 113 of 405 casualties (27.9%), including 8 of the 28 infected casualties, did not affect infection or colonization rates. Conclusions: Although limited by population size, a significant difference in infection rates and multidrug-resistant pathogen colonization was not seen in those casualties who received single-dose broad-spectrum antimicrobials at the point-of-injury, confirming neither benefit nor harm. Overall adherence with initiating point-of-injury antimicrobials was low. C1 [Murray, Clinton K.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA. [Kotwal, Russ S.] USA, Special Operat Command, Ft Bragg, NC USA. [Butler, Frank K.] Def Hlth Board, Washington, DC USA. RP Murray, CK (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@us.army.mil NR 67 TC 10 Z9 12 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S307 EP S313 DI 10.1097/TA.0b013e318227af79 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300011 PM 21814097 ER PT J AU Petersen, K Colyer, MH Hayes, DK Hale, RG Bell, RB AF Petersen, Kyle Colyer, Marcus H. Hayes, David K. Hale, Robert G. Bell, R. Bryan CA Prevention Combat-Related Infect TI Prevention of Infections Associated With Combat-Related Eye, Maxillofacial, and Neck Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE War; Trauma; Head; Face ID OPERATION-IRAQI-FREEDOM; RANDOMIZED CLINICAL-TRIAL; ANTIBIOTIC-PROPHYLAXIS; ENDURING FREEDOM; WAR INJURIES; BACTERIAL ENDOPHTHALMITIS; MANDIBULAR FRACTURES; PENETRATING INJURIES; FACIAL FRACTURES; DECISION-MAKING AB The percentage of combat wounds involving the eyes, maxillofacial, and neck regions reported in the literature is increasing, representing 36% of all combat-related injuries at the start of the Iraq War. Recent meta-analysis of 21st century eye, maxillofacial, and neck injuries described combat injury incidences of 8% to 20% for the face, 2% to 11% for the neck, and 0.5% to 13% for the eye and periocular structures. This article reviews recent data from military and civilian studies to support evidence-based recommendations for the prevention of infections associated with combat-related eye, maxillofacial, and neck injuries. The major emphasis of this review is on recent developments in surgical practice as new antimicrobial studies were not performed. Further studies of bacterial infection epidemiology and postinjury antimicrobial use in combat-related injuries to the eyes, maxillofacial, and neck region are needed to improve evidence-based medicine recommendations. This evidence-based medicine review was produced to support the Guidelines for the Prevention of Infections associated with Combat-related Injuries: 2011 Update contained in this supplement of Journal of Trauma. C1 [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA. [Colyer, Marcus H.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA. [Hayes, David K.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hale, Robert G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Petersen, K (reprint author), USN, Med Res Ctr, 503 Robert Grant Ave, Bethesda, MD 20889 USA. EM kyle.petersen@med.navy.mil FU US Army Medical Command FX Financial support for the consensus conference and publication of the Journal of Trauma supplement was provided by the US Army Medical Command. NR 57 TC 6 Z9 8 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 2 BP S264 EP S269 DI 10.1097/TA.0b013e318227ad9a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XB UT WOS:000293849300006 PM 21814092 ER PT J AU Spinella, PC Wade, CE Blackbourne, LH Borgman, MA Zarzabal, LA Du, F Perkins, JG Maegele, M Schreiber, M Hess, JR Jastrow, KM Gonzalez, EA Holcomb, JB Kozar, R AF Spinella, Philip C. Wade, Charles E. Blackbourne, Lorne H. Borgman, Matthew A. Zarzabal, Lee A. Du, Fei Perkins, Jeremy G. Maegele, Marc Schreiber, Martin Hess, John R. Jastrow, Kenneth M., III Gonzalez, Ernest A. Holcomb, John B. Kozar, Rosemary CA Trauma Outcomes Grp TI The Association of Blood Component Use Ratios With the Survival of Massively Transfused Trauma Patients With and Without Severe Brain Injury SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Transfusion; Mortality; Red Blood Cell; Plasma; Platelets ID FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; LIFE-THREATENING COAGULOPATHY; RESPIRATORY-DISTRESS-SYNDROME; MULTIPLE ORGAN FAILURE; LAST 60 YEARS; EXSANGUINATION PROTOCOL; PRODUCT UTILIZATION; CONTROL HEMATOLOGY; COMBAT CASUALTIES AB Background: The effect of blood component ratios on the survival of patients with traumatic brain injury (TBI) has not been studied. Methods: A database of patients transfused in the first 24 hours after admission for injury from 22 Level I trauma centers over an 18-month period was queried to find patients who (1) met different definitions of massive transfusion (5 units red blood cell [RBC] in 6 hours vs. 10 units RBC in 24 hours), (2) received high or low ratios of platelets or plasma to RBC units (<1:2 vs. >= 1:2), and (3) had severe TBI (head abbreviated injury score >= 3) (TBI+). Results: Of 2,312 total patients, 850 patients were transfused with >= 5 RBC units in 6 hours and 807 could be classified into TBI+ (n = 281) or TBI- (n = 526). Six hundred forty-three patients were transfused with >= 10 RBC units in 24 hours with 622 classified into TBI+ (n = 220) and TBI- (n = 402). For both high-risk populations, a high ratio of platelets:RBCs (not plasma) was independently associated with improved 30-day survival for patients with TBI+ and a high ratio of plasma:RBCs (not platelets) was independently associated with improved 30-day survival in TBI- patients. Conclusions: High platelet ratio was associated with improved survival in TBI+ patients while a high plasma ratio was associated with improved survival in TBI- patients. Prospective studies of blood product ratios should include TBI in the analysis for determination of optimal use of ratios on outcome in injured patients. C1 [Spinella, Philip C.] St Louis Childrens Hosp, Div Crit Care Med, Dept Pediat, St Louis, MO 63110 USA. [Spinella, Philip C.; Wade, Charles E.; Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Borgman, Matthew A.] Childrens Hosp, Dept Pediat, Boston, MA 02115 USA. [Zarzabal, Lee A.; Du, Fei] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Maegele, Marc] Merheim Med Ctr, Dept Surg, Cologne, Germany. [Schreiber, Martin] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. [Hess, John R.] R Adams Cowley Shock Trauma Ctr, Dept Pathol, Baltimore, MD USA. [Jastrow, Kenneth M., III; Gonzalez, Ernest A.; Holcomb, John B.; Kozar, Rosemary] Univ Texas Hlth Sci Ctr, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX USA. RP Spinella, PC (reprint author), St Louis Childrens Hosp, Div Crit Care Med, Dept Pediat, 1 Childrens Pl,Campus Box 8116, St Louis, MO 63110 USA. EM spinella_p@wustl.kids.edu RI Hess, John/K-4001-2013; Borgman, Matthew/L-9477-2015 OI Hess, John/0000-0001-8596-4420; Borgman, Matthew/0000-0002-2008-7380 FU US Army [W81XWH-07-1-0717] FX We thank Joel Michalek, PhD, for his contributions to the statistical analysis and preparation of the manuscript. The authors wish to acknowledge the support of the numerous research coordinators at the various centers. This work was funded in part by a grant from the US Army to the University of Texas Health Science Center San Antonio, W81XWH-07-1-0717. NR 44 TC 7 Z9 7 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2011 VL 71 SU 3 BP S343 EP S352 DI 10.1097/TA.0b013e318227ef2d PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 806XE UT WOS:000293849700005 ER PT J AU Hwang, PF Rice, DC Patel, SV Multherjee, D AF Hwang, Paul F. Rice, Dana C. Patel, Sunil V. Multherjee, Dipankar TI Successful management of renal artery aneurysm rupture after cesarean section SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID AUTOTRANSPLANTATION; PREGNANCY; REPAIR AB Renal artery aneurysm is a rare entity, and patients are usually asymptomatic at the time of presentation. These aneurysms arc rare among pregnant patients, especially after childbirth, and usually form due to changes in vascular wall integrity secondary to hormonal and hemodynamic changes. Here we describe a patient with an intraparenchymal renal artery aneurysm that ruptured after a cesarean section but was immediately identified and managed appropriately, allowing for a successful outcome. (J Vase Surg 2011;54:519-21.) C1 [Hwang, Paul F.] Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. [Rice, Dana C.] George Washington Univ, Med Ctr, Dept Urol, Washington, DC 20037 USA. [Patel, Sunil V.] Fairfax Hosp, Dept Surg, INOVA, Urol Surg Sect, Falls Church, VA 22046 USA. [Multherjee, Dipankar] Fairfax Hosp, Dept Surg, INOVA, Vasc Surg Sect, Falls Church, VA 22046 USA. RP Multherjee, D (reprint author), 2921 Telestar Court,Ste 140, Falls Church, VA 22042 USA. EM muk1953@aol.com NR 15 TC 3 Z9 4 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD AUG PY 2011 VL 54 IS 2 BP 519 EP 521 DI 10.1016/j.jvs.2010.12.041 PG 3 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 806NH UT WOS:000293814400042 PM 21316184 ER PT J AU Hipp, SJ Steffen-Smith, E Hammoud, D Shih, JH Bent, R Warren, KE AF Hipp, Sean J. Steffen-Smith, Emilie Hammoud, Dima Shih, Joanna H. Bent, Robyn Warren, Katherine E. TI Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging SO NEURO-ONCOLOGY LA English DT Article DE diffuse intrinsic pontine glioma; MR spectroscopy; pediatric; prognosis; susceptibility perfusion ID PEDIATRIC BRAIN-TUMORS; STEM GLIOMAS; ADULTS; MRI AB Noninvasive evaluation using MRI is the primary means to routinely assess children with diffuse intrinsic pontine gliomas (DIPGs). However, no standard MR sequence has correlated with outcome in these patients. In this study, patients with DIPGs were assessed to determine the combined prognostic value via dynamic susceptibility contrast (DSC) MRI, single-voxel spectroscopy (SVS), multivoxel MR spectroscopy (MRS), and T1-weighted post-gadolinium imaging. Eligible patients had clinical and radiographic findings consistent with a DIPG. Imaging studies were acquired on a 1.5T MRI at various time points during each patient's course. Data were evaluated using a Cox proportional hazard model, a time-dependent covariant Cox model, a Wald test, and a Kaplan-Meier analysis. Ninety-eight studies were performed on 34 patients of median age 5.5 years. Median survival from diagnosis was 468 days. At baseline imaging only, increased ratio of choline to N-acetylaspartate (Cho:NAA) on SVS and increased perfusion on DSC-MRI each predicted shorter survival (relative risk [RR] = 1.48, P = .015 and RR = 4.91, P = .0012, respectively). When analyzing all subsequent time points, increased maximum Cho:NAA on MRS (RR = 1.45, P = .042), increased Cho:NAA on SVS (RR = 1.69, P = .003), increased perfusion (RR = 4.68, P = .0016), and the presence of enhancement (RR = 5.69, P = .022) each predicted shorter survival. Kaplan-Meier analysis showed shorter survival associated with increased perfusion at baseline (P = .0004). Increased perfusion at any time point predicts a significantly shorter survival in children with DIPG. In addition, enhancement, increased Cho:NAA on SVS, and increased maximum Cho:NAA on chemical shift imaging are predictive of shorter survival over time. Routine baseline and subsequent imaging for children with DIPG should, at minimum, incorporate DSC-MRI and SVS. C1 [Hipp, Sean J.; Steffen-Smith, Emilie; Bent, Robyn; Warren, Katherine E.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Hipp, Sean J.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Hipp, Sean J.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Hammoud, Dima] NIH, Dept Diagnost Radiol, Ctr Clin, Bethesda, MD 20892 USA. [Shih, Joanna H.] NCI, Biometr Res Branch, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA. RP Hipp, SJ (reprint author), NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bldg 10,Room 1-5750,9000 Rockville Pike, Bethesda, MD 20892 USA. EM sean.hipp@us.army.mil RI Hammoud, Dima/C-2286-2015 FU National Institutes of Health, National Cancer Institute, and Center for Cancer Research FX This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, and Center for Cancer Research. NR 18 TC 28 Z9 30 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1522-8517 J9 NEURO-ONCOLOGY JI Neuro-Oncology PD AUG PY 2011 VL 13 IS 8 BP 904 EP 909 DI 10.1093/neuonc/nor076 PG 6 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 806PU UT WOS:000293820900011 PM 21757444 ER PT J AU Vanfosson, CA AF Vanfosson, Christopher A. TI Welcome Home SO AMERICAN JOURNAL OF NURSING LA English DT Editorial Material C1 [Vanfosson, Christopher A.] USA, Nurse Corps, Ft Bragg, NC USA. [Vanfosson, Christopher A.] 541st Forward Surg Team Airborne, Ft Bragg, NC USA. RP Vanfosson, CA (reprint author), USA, Nurse Corps, Ft Bragg, NC USA. EM christopher.vanfosson@mail.us.army.mil OI VanFosson, Christopher/0000-0003-1640-3018 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD AUG PY 2011 VL 111 IS 8 BP 67 EP 69 DI 10.1097/01.NAJ.0000403371.43165.85 PG 3 WC Nursing SC Nursing GA 799FR UT WOS:000293271000023 PM 21795943 ER PT J AU Folio, LR Fischer, T Shogan, P Frew, M Dwyer, A Provenzale, JM AF Folio, Les R. Fischer, Tatjana Shogan, Paul Frew, Michael Dwyer, Andrew Provenzale, James M. TI Blast and Ballistic Trajectories in Combat Casualties: A Preliminary Analysis Using a Cartesian Positioning System With MDCT SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE ballistic injuries; blast injuries; trajectory; wound path ID GUIDED VIRTUAL AUTOPSY; BULLET; RADIOLOGY; INJURIES; HEAD AB OBJECTIVE. The purpose of this study is to determine the agreement with which radiologists identify wound paths in vivo on MDCT and calculate missile trajectories on the basis of Cartesian coordinates using a Cartesian positioning system (CPS). MATERIALS AND METHODS. Three radiologists retrospectively identified 25 trajectories on MDCT in 19 casualties who sustained penetrating trauma in Iraq. Trajectories were described qualitatively in terms of directional path descriptors and quantitatively as trajectory vectors. Directional descriptors, trajectory angles, and angles between trajectories were calculated based on Cartesian coordinates of entrance and terminus or exit recorded in x, y image and table space (z) using a Trajectory Calculator created using spreadsheet software. The consistency of qualitative descriptor determinations was assessed in terms of frequency of observer agreement and multirater kappa statistics. Consistency of trajectory vectors was evaluated in terms of distribution of magnitude of the angles between vectors and the differences between their paraaxial and parasagittal angles. RESULTS. In 68% of trajectories, the observers' visual assessment of qualitative descriptors was congruent. Calculated descriptors agreed across observers in 60% of the trajectories. Estimated kappa also showed good agreement (0.65-0.79, p < 0.001); 70% of calculated paraaxial and parasagittal angles were within 20 degrees across observers, and 61.3% of angles between trajectory vectors were within 20 degrees across observers. CONCLUSION. Results show agreement of visually assessed and calculated qualitative descriptors and trajectory angles among observers. The Trajectory Calculator describes trajectories qualitatively similar to radiologists' visual assessment, showing the potential feasibility of automated trajectory analysis. C1 [Folio, Les R.; Dwyer, Andrew] NIH, Dept Radiol, Bethesda, MD 20892 USA. [Fischer, Tatjana] Univ Munich, Munich, Germany. [Shogan, Paul; Frew, Michael] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Provenzale, James M.] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Oncol, Atlanta, GA USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Biomed Engn, Atlanta, GA USA. RP Folio, LR (reprint author), NIH, Dept Radiol, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM Les.folio@nih.gov NR 20 TC 5 Z9 5 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD AUG PY 2011 VL 197 IS 2 BP W233 EP W240 DI 10.2214/AJR.10.5959 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 796OY UT WOS:000293062600004 PM 21785047 ER PT J AU Posner, M Cameron, KL Wolf, JM Belmont, PJ Owens, BD AF Posner, Matthew Cameron, Kenneth L. Wolf, Jennifer Moriatis Belmont, Philip J., Jr. Owens, Brett D. TI Epidemiology of Major League Baseball Injuries SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Orthopaedic-Society-for-Sports-Medicine CY JUL, 2010 CL Providence, RI SP Amer Orthopaed Soc Sports Med DE baseball; injury; sports; epidemiology; pitcher AB Background: Little is known about the injury rates in Major League Baseball (MLB) players, as a formal injury surveillance system does not exist. The goal of this study was to characterize the epidemiology of MLB injuries over a 7-year period. Hypothesis: Injuries in MLB would be common. Study Design: Descriptive epidemiologic study. Methods: The authors analyzed the MLB disabled list data from 2002 through 2008. Injuries were analyzed for differences between seasons, as well as during seasons on a monthly basis. The injuries were categorized by major anatomic zones and then further stratified based on injury type. Position-specific subanalyses for pitcher and position players were performed. Results: From the 2002 season through the 2008 season, an average of 438.9 players per year were placed on the disabled list, for a rate of 3.61 per 1000 athlete-exposures. There was a significant 37% increase in injuries between 2005 and 2008. The highest injury rate during the season was during the month of April (5.73/1000 exposures) and the lowest in September (0.54/1000 exposures). No differences were noted in the injury rates between the National League and the American League (incidence rate ratio [IRR] = 1.06; 95% confidence interval [CI] = 0.98, 1.15). Pitchers experienced 34% higher incidence rates for injury compared with fielders during the study period (IRR = 1.34; 95% CI = 1.25, 1.44). Among all player injuries, upper extremity injuries accounted for 51.4% while lower extremity injuries accounted for 30.6%. Injuries to the spine and core musculature accounted for 11.7% while other injuries and illnesses were 6.3% of the total disabled list entries. There was a significant association between position played and anatomic region injured (P < .001), with pitchers experiencing a significantly greater proportion of injuries to the upper extremity (67.0%; 95% CI = 63.1%, 70.9%) compared with fielders (32.1%; 95% CI = 29.1%, 35.1%). Conversely, fielders experienced a significantly greater proportion of injuries to the lower extremity (47.5%; 95% CI = 43.8%, 51.1%) compared with pitchers (16.9%; 95% CI = 14.9%, 18.8%). The mean number of days on the disabled list was 56.6. Overall, a greater proportion of disability days were experienced by pitchers (62.4%; 95% CI = 62.0%, 62.8%; P < .001) compared with fielders (37.6%; 95% CI = 37.3%, 37.9%). Conclusion: Injuries in MLB resulting in disabled list designation are common. Upper extremity injuries were predominant in pitchers, while lower extremity injuries are more common in position players. These data may be used in the development of a formal MLB injury database, as well as in the development and implementation of specific preseason training and in-season conditioning for injury prevention. C1 [Posner, Matthew; Cameron, Kenneth L.; Wolf, Jennifer Moriatis; Belmont, Philip J., Jr.; Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Belmont, Philip/0000-0003-2618-199X; Cameron, Kenneth/0000-0002-6276-4482 NR 7 TC 45 Z9 45 U1 1 U2 16 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD AUG PY 2011 VL 39 IS 8 BP 1676 EP 1680 DI 10.1177/0363546511411700 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 800SO UT WOS:000293387400010 PM 21709023 ER PT J AU Lu, F Gao, Q Chotivanich, K Xia, H Cao, J Udomsangpetch, R Cui, LW Sattabongkot, J AF Lu, Feng Gao, Qi Chotivanich, Kesinee Xia, Hui Cao, Jun Udomsangpetch, Rachanee Cui, Liwang Sattabongkot, Jetsumon TI In vitro Anti-Malarial Drug Susceptibility of Temperate Plasmodium vivax from Central China SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID REPUBLIC-OF-KOREA; PAPUA-NEW-GUINEA; FALCIPARUM-MALARIA; IRIAN-JAYA; CHLOROQUINE RESISTANCE; PRIMAQUINE THERAPY; WESTERN BORDER; INDONESIA; SENSITIVITY; THAILAND AB In the face of recent increase of Plasmodium vivax malaria in central China, we conducted a study to evaluate in vitro susceptibility of temperate-zone P vivax parasites to antimalarial drugs. During 2005-2006, in vitro drug susceptibility was measured for 42 clinical P vivax isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (IC(50)s) and 95% confidence intervals (CIs) were 10.87 (4.50-26.26) ng/mL for chloroquine, 4.21 (1.88-9.42-8) ng/mL for mefloquine, 11.82 (6.20-22.56) ng/mL for quinine, 0.13 (0.09-0.20) ng/mL for artesunate, 18.32 (8.08-41.50) ng/mL for pyrimethamine, and 17.73 (10.29-30.57) ng/mL for piperaquine. The IC50 for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against P vivax malaria in central China. The results further indicated that temperate-zone P vivax isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand. C1 [Lu, Feng; Gao, Qi; Cao, Jun] Jiangsu Inst Parasit Dis, Wuxi 214064, Jiangsu, Peoples R China. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [Chotivanich, Kesinee] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand. [Xia, Hui] Bengbu Med Coll, Dept Parasitol, Bengbu 233030, Anhui, Peoples R China. [Cui, Liwang] Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Sattabongkot, J (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM gaoqi54@hotmail.com; jetsumon@hotmail.com FU U.S. Military Infectious Diseases Research Program; Major State Basic Research Development Program of China [2007CB513100] FX This study was supported by the U.S. Military Infectious Diseases Research Program and a grant from the Major State Basic Research Development Program of China (973 Program, No. 2007CB513100). NR 60 TC 10 Z9 12 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2011 VL 85 IS 2 BP 197 EP 201 DI 10.4269/ajtmh.2011.10-0070 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 803WN UT WOS:000293613000003 PM 21813834 ER PT J AU Watanaveeradej, V Simasathien, S Nisalak, A Endy, TP Jarman, RG Innis, BL Thomas, SJ Gibbons, RV Hengprasert, S Samakoses, R Kerdpanich, A Vaughn, DW Putnak, JR Eckels, KH De la Barrera, R Mammen, MP AF Watanaveeradej, Veerachai Simasathien, Sriluck Nisalak, Ananda Endy, Timothy P. Jarman, Richard G. Innis, Bruce L. Thomas, Stephen J. Gibbons, Robert V. Hengprasert, Sumetha Samakoses, Rudiwilai Kerdpanich, Angkool Vaughn, David W. Putnak, J. Robert Eckels, Kenneth H. De la Barrera, Rafael Mammen, Mammen P., Jr. TI Safety and Immunogenicity of a Tetravalent Live-Attenuated Dengue Vaccine in Flavivirus-Naive Infants SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS-VACCINE; ANTIBODIES; COUNTRIES; DISEASE; PCR AB A Phase I/II observer-blind, randomized, controlled trial evaluated the safety and immunogenicity of a dengue virus (DENV) vaccine candidate in healthy Thai infants (aged 12-15 months) without measurable pre-vaccination neutralizing antibodies to DENV and Japanese encephalitis virus. Fifty-one subjects received two doses of either DENV (N = 34; four received 1/10th dose) or control vaccine (N = 17; dose 1, live varicella; dose 2, Haemophilus influenzue type b). After each vaccine dose, adverse events (AEs) were solicited for 21 days, and non-serious AEs were solicited for 30 days; serious AEs (SAEs) were recorded throughout the study. Laboratory safety assessments were performed at 10 and 30 days; neutralizing antibodies were measured at 30 days. The DENV vaccine was well-tolerated without any related SAEs. After the second dose, 85.7% of full-dose DENV vaccinees developed at least trivalent and 53.6% developed tetravalent neutralizing antibodies >= 1:10 to DENV (control group = 0%). This vaccine candidate, therefore, warrants continued development in this age group (NCT00322049; clinicaltrials.gov). C1 [Mammen, Mammen P., Jr.] US Army Med Mat Dev Act, Pharmaceut Syst Program Management Off, Ft Detrick, MD 21702 USA. Phramongkutklao Hosp PMK, Dept Pediat, Bangkok, Thailand. [Nisalak, Ananda; Jarman, Richard G.; Thomas, Stephen J.; Gibbons, Robert V.; Hengprasert, Sumetha] AFRIMS, Dept Virol, Bangkok, Thailand. GlaxoSmithKline Biol, King Of Prussia, PA USA. GlaxoSmithKline Biol, Rixensart, Belgium. GlaxoSmithKline Biol, Bangkok, Thailand. [Putnak, J. Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. [Eckels, Kenneth H.; De la Barrera, Rafael] Walter Reed Army Inst Res, Div Regulated Act, Pilot Bioprod Facil, Silver Spring, MD USA. [Watanaveeradej, Veerachai; Simasathien, Sriluck; Samakoses, Rudiwilai; Kerdpanich, Angkool] Phramongkutklao Hosp, Dept Pediat, Bangkok, Thailand. [Endy, Timothy P.] SUNY Upstate Med Univ, Div Infect Dis, Dept Med, Syracuse, NY USA. [Innis, Bruce L.; Vaughn, David W.] GlaxoSmithKline, King Of Prussia, PA USA. RP Mammen, MP (reprint author), US Army Med Mat Dev Act, Pharmaceut Syst Program Management Off, 1430 Vet Dr, Ft Detrick, MD 21702 USA. EM veerachaiw@yahoo.com; ssriluck@hotmail.com; ananda.nisalak@afrims.org; endyt@upstate.edu; richard.jarman@afrims.org; bruce.2.innis@gsk.com; Stephen.thomas@afrims.org; Robert.gibbons@afrims.org; sumethah@afrims.org; rudiwilai_samakoses@hotmail.com; akpmk@yahoo.com; david.w.vaughn@gsk.com; robert.putnak@amedd.army.mil; kenneth.eckels@amedd.army.mil; rafael.delabarreral@us.army.mil; mammen.mammen@us.army.mil FU US Army Medical Research and Materiel Command (Fort Detrick, MD); GlaxoSmithKline (Rixensart, Belgium) FX This work was funded by US Army Medical Research and Materiel Command (Fort Detrick, MD) and GlaxoSmithKline (Rixensart, Belgium). NR 20 TC 28 Z9 30 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2011 VL 85 IS 2 BP 341 EP 351 DI 10.4269/ajtmh.2011.10-0501 PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 803WN UT WOS:000293613000026 PM 21813857 ER PT J AU Ray, R Zhang, P Ray, P AF Ray, Radharaman Zhang, Peng Ray, Prabhati TI Neuronal Functions Associated with Endo- and Exocytotic Events-cum-Molecular Trafficking may be Cell Maturation-Dependent: Lessons Learned from Studies on Botulism SO CELLULAR AND MOLECULAR NEUROBIOLOGY LA English DT Article DE Neurons; Functions; Endocytosis; Exocytosis; Molecular trafficking; Cell maturation; Botulism; Targeted therapeutic ID SYNAPSE FORMATION AB The passion in the scientific endeavors of Marshall Warren Nirenberg had been his quest for knowledge regarding the storage, retrieval, and processing of information in the cell. After deciphering the genetic code for which he shared the Nobel Prize in Physiology and Medicine in 1968, Nirenberg devoted his attention to unraveling the mysteries in the most complex cellular organization in the body, i.e., the nervous system, especially those governing neuronal development, plasticity, and synaptogenesis. During the tenure of the primary author (RR) as a postdoctoral Staff Fellow in the Nirenberg laboratory in the late seventies to early eighties, he had the opportunity of working on projects related to what Nirenberg used to broadly define as the "synaptic code.'' The major aspects of these projects dealt with the functional macromolecules relevant to neuronal growth, organization, lineage, selectivity, stabilization, synaptogenesis, and functions such as neuroexocytosis. This author's emphasis was particularly on voltage-gated calcium channels that regulate stimulus-induced neurotransmitter release. One central as well as crucial theme in these studies was the fact that the neurons had to be mature and differentiated in order to study these entities (Science 222: 794-799, 1983; Cold Spring Harb Symp Quant Biol 48: 707-715, 1983). In this communication, we illustrate how did this basic knowledge, i.e., cell maturation-dependent properties being essential for neuronal functions, led to a successful experimental design and demonstration of the validity of the targeted neurologic therapeutic delivery approach based on recombinant botulinum toxin serotype A (BoNT/A) heavy chain (rHC) serving as a neuron-specific targeting molecule (BMC Pharmacol 9: 12, 2009). C1 [Ray, Radharaman] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Zhang, Peng; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Ray, R (reprint author), USA, Med Res Inst Chem Def, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM radharaman.ray@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX This study was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. NR 6 TC 1 Z9 1 U1 0 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0272-4340 J9 CELL MOL NEUROBIOL JI Cell. Mol. Neurobiol. PD AUG PY 2011 VL 31 IS 6 SI SI BP 861 EP 865 DI 10.1007/s10571-011-9678-1 PG 5 WC Cell Biology; Neurosciences SC Cell Biology; Neurosciences & Neurology GA 799ZF UT WOS:000293325300008 PM 21625961 ER PT J AU Adler, M Sweeney, RE Hamilton, TA Lockridge, O Duysen, EG Purcell, AL Deshpande, SS AF Adler, Michael Sweeney, Richard E. Hamilton, Tracey A. Lockridge, Oksana Duysen, Ellen G. Purcell, Angela L. Deshpande, Sharad S. TI Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice SO CELLULAR AND MOLECULAR NEUROBIOLOGY LA English DT Article DE Neuromuscular junction; Cholinesterase; Knockout mouse; Diaphragm muscle; Electron microscopy; Endplate potential ID QUANTAL TRANSMITTER RELEASE; BUTYRYLCHOLINESTERASE ACTIVITY; CHOLINESTERASE INHIBITOR; RAT DIAPHRAGM; MUSCLE; MOUSE; RECEPTORS; FROG; SUPERSENSITIVITY; DESENSITIZATION AB Electrophysiological and ultrastructural studies were performed on phrenic nerve-hemidiaphragm preparations isolated from wild-type and acetylcholinesterase (AChE) knockout (KO) mice to determine the compensatory mechanisms manifested by the neuromuscular junction to excess acetylcholine (ACh). The diaphragm was selected since it is the primary muscle of respiration, and it must adapt to allow for survival of the organism in the absence of AChE. Nerve-elicited muscle contractions, miniature endplate potentials (MEPPs) and evoked endplate potentials (EPPs) were recorded by conventional electrophysiological techniques from phrenic nerve-hemidiaphragm preparations isolated from 1.5- to 2-month-old wild-type (AChE(+/+)) or AChE KO (AChE(-/-)) mice. These recordings were chosen to provide a comprehensive assessment of functional alterations of the diaphragm muscle resulting from the absence of AChE. Tension measurements from AChE(-/-) mice revealed that the amplitude of twitch tensions was potentiated, but tetanic tensions underwent a use-dependent decline at frequencies below 70 Hz and above 100 Hz. MEPPs recorded from hemidiaphragms of AChE(-/-) mice showed a reduction in frequency and a prolongation in decay (37%) but no change in amplitude compared to values observed in age-matched wild-type littermates. In contrast, MEPPs recorded from hemidiaphragms of wild-type mice that were exposed for 30 min to the selective AChE inhibitor 5-bis(4-allyldimethyl-ammoniumphenyl)pentane-3-one (BW284C51) exhibited a pronounced increase in amplitude (42%) and a more marked prolongation in decay (76%). The difference between MEPP amplitudes and decays in AChE(-/-) hemidiaphragms and in wild-type hemidiaphragms treated with BW284C51 represents effective adaptation by the former to a high ACh environment. Electron microscopic examination revealed that diaphragm muscles of AChE(-/-) mice had smaller nerve terminals and diminished pre- and post-synaptic surface contacts relative to neuromuscular junctions of AChE(+/+) mice. The morphological changes are suggested to account, in part, for the ability of muscle from AChE(-/-) mice to function in the complete absence of AChE. C1 [Adler, Michael; Purcell, Angela L.; Deshpande, Sharad S.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. [Sweeney, Richard E.] USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. [Hamilton, Tracey A.] USA, Med Res Inst Chem Def, Res Support Div, Comparat Pathol Branch, Aberdeen Proving Ground, MD 21010 USA. [Lockridge, Oksana; Duysen, Ellen G.] Univ Nebraska, Med Ctr, Eppley Inst, Omaha, NE 68198 USA. RP Adler, M (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. EM michael.adler2@us.army.mil OI Duysen, Ellen/0000-0002-0128-9032 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX We dedicate this article to the memory of Dr. Marshall Nirenberg, in whose laboratory the primary author (MA) had the privilege of working from 1978 to 1982. Dr. Nirenberg was a strong proponent of using genetic tools for solving problems in neurobiology and for tackling important scientific issues regardless of their complexity. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. In conducting the research described in this report, the investigators complied with the regulations and standards of the Animal Welfare Act and adhered to the principles of the Guide for the Care and Use of Laboratory Animals (http://www.nap.edu/catalog.php?record_id=12910). NR 41 TC 2 Z9 2 U1 0 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0272-4340 J9 CELL MOL NEUROBIOL JI Cell. Mol. Neurobiol. PD AUG PY 2011 VL 31 IS 6 SI SI BP 909 EP 920 DI 10.1007/s10571-011-9690-5 PG 12 WC Cell Biology; Neurosciences SC Cell Biology; Neurosciences & Neurology GA 799ZF UT WOS:000293325300013 PM 21538119 ER PT J AU Tachibana, M Wu, YM Iriko, H Muratova, O MacDonald, NJ Sattabongkot, J Takeo, S Otsuki, H Torii, M Tsuboi, T AF Tachibana, Mayumi Wu, Yimin Iriko, Hideyuki Muratova, Olga MacDonald, Nicholas J. Sattabongkot, Jetsumon Takeo, Satoru Otsuki, Hitoshi Torii, Motomi Tsuboi, Takafumi TI N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking Activity SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID GAMETE-SURFACE PROTEIN; SEXUAL-STAGE ANTIGEN; PLASMODIUM-FALCIPARUM; VACCINE CANDIDATES; TARGET ANTIGEN; ANTIBODIES; EXPRESSION; IMMUNITY; VIVAX; PVS25 AB The aim of a malaria transmission-blocking vaccine is to block the development of malaria parasites in the mosquito and thus prevent subsequent infection of the human host. Previous studies have demonstrated that the gametocyte/gamete surface protein Pfs230 can induce transmission-blocking immunity and have evaluated Escherichia coli-produced Pfs230 as a transmission-blocking vaccine candidate. In this study, we used the wheat germ cell-free expression system to produce N-terminal fragments of Pfs230 and evaluated the transmission-blocking activity of antisera raised against the recombinant Pfs230 protein. The rabbit antisera reacted to the surface of cultured gametocytes and gametes of the Plasmodium falciparum NF54 line, recognized the 360-kDa form of parasite-produced Pfs230 by Western blot assay, and reduced the infectivity of NF54 parasites to Anopheles stefensi mosquitoes in the presence of complement in a standard membrane feeding assay. Thus, our data demonstrate that the N-terminal pro domain of Pfs230 is sufficient to induce complement-dependent transmission-blocking activity against P. falciparum. C1 [Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan. [Wu, Yimin; Muratova, Olga; MacDonald, Nicholas J.] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD 20852 USA. [Iriko, Hideyuki; Otsuki, Hitoshi] Tottori Univ, Fac Med, Div Med Zool, Tottori 6838503, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Torii, Motomi; Tsuboi, Takafumi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. EM torii@m.ehime-u.ac.jp; tsuboi@ccr.ehime-u.ac.jp FU Ministry of Education, Culture, Sports, Science and Technology [21022034, 21249028, 21406010]; Ministry of Health, Labor, and Welfare, Japan [H20-Shinkou-ippan-013, H21-Chikyukibo-ippan-005]; Bill and Melinda Gates Foundation FX This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology (21022034, 21249028, 21406010) and by the Ministry of Health, Labor, and Welfare, Japan (H20-Shinkou-ippan-013, H21-Chikyukibo-ippan-005). This work was also supported in part by a grant from The Bill and Melinda Gates Foundation. NR 44 TC 26 Z9 26 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD AUG PY 2011 VL 18 IS 8 BP 1343 EP 1350 DI 10.1128/CVI.05104-11 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 800ID UT WOS:000293352100019 PM 21715579 ER PT J AU Kim, WI Larar, JG Cheson, BD Lee, RK Palmberg, PF AF Kim, Won I. Larar, Jeanette G. Cheson, Bruce D. Lee, Richard K. Palmberg, Paul F. TI Resolution of Lymphoma-associated Open-angle Glaucoma by Rituximab SO JOURNAL OF GLAUCOMA LA English DT Article DE open-angle glaucoma; glaucoma; conjunctival lymphoma; ocular adnexal lymphoma; lymphoma; rituximab ID NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; INVOLVEMENT AB Purpose: To report a patient who developed open-angle glaucoma, secondary to bilateral perilimbal conjunctival lymphoid infiltrates without intraocular involvement that resolved after treatment with systemic rituximab. Methods: Observational case report. Results: Review of historic, clinical, and photographic data of a 67-year-old woman with non-Hodgkin lymphoma of the axillary and cervical lymph nodes and bilateral perilimbal conjunctival lymphoid infiltrates who presented for treatment of uncontrolled chronic open-angle glaucoma on maximum medical therapy. The elevated intraocular pressures and conjunctival lesions resolved after treatment of the systemic lymphoma with rituximab. The patient was followed for a period of 6 years without recurrence of the conjunctival lesions, with low normal intraocular pressures without progressive optic nerve damage off all glaucoma treatments. Conclusions: Open-angle glaucoma can result as a consequence of isolated conjunctival lymphoid tumors and can resolve with successful treatment of lymphoid lesions. The mechanism of glaucoma may be obstruction of aqueous outflow to the episcleral and conjunctival veins either by compression from a mass effect or direct infiltration that is relieved with resolution of the conjunctival lymphoid lesions. We believe this is a unique presentation of glaucoma associated with lymphoid tumors that has not been reported earlier. C1 [Kim, Won I.] BAMC MCHE SDO, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Larar, Jeanette G.; Lee, Richard K.; Palmberg, Paul F.] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA. [Cheson, Bruce D.] Georgetown Univ Hosp, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA. RP Kim, WI (reprint author), BAMC MCHE SDO, Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM won.kim1@us.army.mil NR 15 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1057-0829 J9 J GLAUCOMA JI J. Glaucoma PD AUG PY 2011 VL 20 IS 6 BP 398 EP 400 DI 10.1097/IJG.0b013e3181efb334 PG 3 WC Ophthalmology SC Ophthalmology GA 801NJ UT WOS:000293446400013 PM 20852443 ER PT J AU Miller, J Gerber, JP AF Miller, Joseph Gerber, J. Parry TI Posterior Distal Tibial Fracture in a Military Trainee SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Miller, Joseph; Gerber, J. Parry] US Mil Acad, US Mil Baylor Sports Med Phys Therapy Doctoral Pr, West Point, NY 10996 USA. [Gerber, J. Parry] Baylor Univ, Waco, TX 76798 USA. RP Miller, J (reprint author), US Mil Acad, US Mil Baylor Sports Med Phys Therapy Doctoral Pr, West Point, NY 10996 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2011 VL 41 IS 8 BP 615 EP 615 DI 10.2519/jospt.2011.0417 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 800MI UT WOS:000293364600010 PM 21808103 ER PT J AU Hawley, JS Weiner, WJ AF Hawley, Jason S. Weiner, William J. TI Psychogenic dystonia and peripheral trauma SO NEUROLOGY LA English DT Review ID REGIONAL PAIN SYNDROME; POSTTRAUMATIC MOVEMENT-DISORDERS; REFLEX SYMPATHETIC DYSTROPHY; FOCAL HAND DYSTONIA; CERVICAL DYSTONIA; INTRATHECAL BACLOFEN; INDUCE DYSTONIA; PLASTICITY; ONSET; TORTICOLLIS AB Dystonia in association with peripheral trauma is a well-described clinical syndrome. The syndrome goes by many names-"traumatic" dystonia, "fixed" dystonia, peripherally induced dystonia, or complex region pain syndrome (CRPS) dystonia. We reviewed the role of peripheral trauma in the development of dystonia, focusing on 4 subtypes-cervical dystonia, focal limb dystonia, CRPS dystonia, and psychogenic dystonia. We show that peripheral trauma inducing, provoking, or precipitating structural changes within the CNS leading to dystonia is not an accepted concept, and current evidence supporting a pathophysiologic mechanism is virtually nonexistent. A better approach to this clinical syndrome is to define it as fixed abnormal posturing that is most commonly psychogenic. While symptomatic treatment of pain and spasms with medication can be beneficial, early psychological evaluation and patient-specific treatment is important. Modalities such as physical and occupational therapy should be utilized early. Finally, it should be emphasized that like many psychogenic movement disorders, it remains a highly disabling and distressing disorder. Neurology (R) 2011;77:496-502 C1 [Hawley, Jason S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Weiner, William J.] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA. RP Hawley, JS (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM Jshawley1@yahoo.com FU Novartis; Santhera Pharmaceuticals; Boehringer Ingelheim FX Dr. Hawley is an active duty medical officer serving in the United States Army. Dr. Weiner has served on scientific advisory boards for Santhera Pharmaceuticals and Rexahn Pharmaceuticals, Inc.; serves on the editorial boards of Parkinsonism and Related Disorders and Neurological Reviews, and as Editor of Treatment Options in Neurology; receives royalties from the publication of Neurology for the Non-Neurologist (6th edition, Wolters Kluwer/Lippincott, 2010), Parkinson's Disease: A Complete Guide for Patients and Family (2nd edition, Hopkins University Press, 2007), and Handbook of Clinical Neurology Hyperkinetic Disorders (Elsevier, 2011); has received research support from Novartis, Santhera Pharmaceuticals, and Boehringer Ingelheim; and has provided expert testimony and served as a subject matter expert in legal proceedings. NR 49 TC 25 Z9 25 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD AUG PY 2011 VL 77 IS 5 BP 496 EP 502 DI 10.1212/WNL.0b013e3182287aaf PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 800RO UT WOS:000293383100019 PM 21810699 ER PT J AU Barnett, JC Havrilesky, LJ Bondurant, AE Fleming, ND Lee, PS Secord, AA Berchuck, A Valea, FA AF Barnett, Jason C. Havrilesky, Laura J. Bondurant, Amy E. Fleming, Nicole D. Lee, Paula S. Secord, Angeles Alvarez Berchuck, Andrew Valea, Fidel A. TI Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 41st Annual Meeting on Women's Cancer of the Society-of-Gynecologic-Oncologists CY MAR 14-17, 2010 CL San Francisco, CA SP Soc Gynecol Oncol DE endometrial cancer; laparoscopy; surgical complications ID ABDOMINAL HYSTERECTOMY; LYMPHADENECTOMY; MORBIDITY; COST AB OBJECTIVE: The objective of the study was to compare adverse event rates between laparoscopic vs open surgery for endometrial cancer. STUDY DESIGN: This was a retrospective cohort study comparing 107 women who underwent laparoscopy with 269 age-and body mass index-matched women who underwent laparotomy for treatment of endometrial cancer. RESULTS: Adverse event rates were similar between cohorts (37% laparoscopy vs 43% laparotomy, P = .248). Laparotomies had higher rates of cellulitis (16% vs 7%, P = .018) and open wound infection (9% vs 2%, P = .02), whereas laparoscopy had higher rates of sensory peripheral nerve deficit (5% vs 0%, P = .008) and lymphedema (7% vs 1%, P = .003). Laparoscopy was associated with longer mean operating room times but with shorter hospital stays and lower mean blood loss. CONCLUSION: Laparoscopy was associated with decreased rates of surgical site infections but had an increased risk of peripheral sensory nerve deficits and lymphedema when compared with laparotomy. C1 [Barnett, Jason C.; Havrilesky, Laura J.; Bondurant, Amy E.; Fleming, Nicole D.; Lee, Paula S.; Secord, Angeles Alvarez; Berchuck, Andrew; Valea, Fidel A.] Duke Univ, Sch Med, Dept Obstet & Gynecol, Div Gynecol Oncol, Durham, NC USA. RP Barnett, JC (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 2 Z9 2 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD AUG PY 2011 VL 205 IS 2 AR 143.e1 DI 10.1016/j.ajog.2011.03.012 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 798ON UT WOS:000293219400030 PM 21514921 ER PT J AU Dykstra, PH Roy, V Byrd, C Bentley, WE Ghodssi, R AF Dykstra, Peter H. Roy, Varnika Byrd, Christopher Bentley, William E. Ghodssi, Reza TI Microfluidic Electrochemical Sensor Array for Characterizing Protein Interactions with Various Functionalized Surfaces SO ANALYTICAL CHEMISTRY LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; BOVINE SERUM-ALBUMIN; QUARTZ-CRYSTAL MICROBALANCE; LABEL-FREE; IMPEDANCE MEASUREMENTS; POLY(ETHYLENE GLYCOL); ADSORPTION; GOLD; DNA; IMMOBILIZATION AB We present a unique microfluidic platform to allow for quick and sensitive probing of protein adsorption to various functionalized surfaces. The ability to tailor a sensor surface for a specific analyte is crucial for the successful application of portable gas and fluid sensors and is of great interest to the drug screening community. However, choosing the correct surface chemistry to successfully passivate against nonspecific binding typically requires repeated trial and error experiments. The presented device incorporates an array of integrated electrochemical sensors for fast, sensitive, label-free detection of these binding interactions. The layout of the electrodes allows for loading various surface chemistries in one direction while sensing their interactions with particular compounds in another without any cross-contamination. Impedance data is collected for three commonly used passivation compounds (mercaptohexanol, polyethylene glycol, and bovine serum albumin) and demonstrates their interaction with three commonly studied proteins in genetic and cancer research (cAMP receptor protein, tumor necrosis factor a, and tumor necrosis factor)3). The ability to quickly characterize various surface interactions provides knowledge for selecting optimal functionalization for any biosensor. C1 [Dykstra, Peter H.; Ghodssi, Reza] Univ Maryland, MEMS Sensors & Actuators Lab MSAL, Syst Res Inst, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Roy, Varnika; Byrd, Christopher; Bentley, William E.; Ghodssi, Reza] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Roy, Varnika] Univ Maryland, Grad Program Mol & Cell Biol, College Pk, MD 20742 USA. [Byrd, Christopher] Univ Maryland, USA, Res Lab, College Pk, MD 20742 USA. RP Dykstra, PH (reprint author), Univ Maryland, MEMS Sensors & Actuators Lab MSAL, Syst Res Inst, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM pdykstra@umd.edu; ghodssi@umd.edu FU R. W. Deutsch Foundation FX The authors acknowledge the R. W. Deutsch Foundation and National Science Foundation Emerging Frontiers in Research and Innovation (EFRI) for financial support. The authors also thank the Maryland Nanocenter and its Fablab for cleanroom facility support. The authors also thank Dr. James Sumner from the Army Research Laboratory. The authors also thank the Defense Threat Reduction Agency (DTRA) and the Office of Naval Research (ONR). NR 44 TC 22 Z9 23 U1 3 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD AUG 1 PY 2011 VL 83 IS 15 BP 5920 EP 5927 DI 10.1021/ac200835s PG 8 WC Chemistry, Analytical SC Chemistry GA 798ZV UT WOS:000293252500018 PM 21688780 ER PT J AU Smith, CB Anderson, JE Edwards, JD Kam, KC AF Smith, Clint B. Anderson, John E. Edwards, Jarrod D. Kam, Kinson C. TI In Situ Surface-Etched Bacterial Spore Detection Using Dipicolinic Acid-Europium-Silica Nanoparticle Bioreporters SO APPLIED SPECTROSCOPY LA English DT Article DE Molecularly imprinted polymers; MCM silica; Dipicolinic acid; DPA; Bacterial endospores; Sensors ID ANTHRAX BIOMARKER; ENDOSPORE DETECTION; IMPRINTED POLYMERS; PHOTOLUMINESCENCE; LUMINESCENCE; GERMINATION; SENSOR; WATER; TERBIUM(III); SPECTROSCOPY AB A basic approach was optimized for the synthesis of highly selective and sensitive in situ mesoporous (MCM) type imprinted silica polymers for the detection of dipicolinic acid (DPA) using europium as a reporter. DPA is a ubiquitous biochemical marker available during the germination event of endospore-forming bacteria such as Bacillus. Additionally, an MCM-MIP (molecularly imprinted polymeric phenomena) detector and a companion MCM non-surface MIP detector were synthesized using europium reporters for the sensing of DPA under optimized laboratory conditions. Our results showed that the in situ molecular imprinting process enabled rapid, selective detection of DPA with high sensitivity compared to MCM-MIP (imprinted for DPA; no DPA present), MCM-Non-MIP (no imprint present), and MCM-SR-MIP (imprinted with DPA present) detectors. The lower detection limit observed for DPA concentration is 5.49 x 10(-10) mol dm(-3) for MCM-MIP. The performance of the sensor in high-salt-water conditions, under photo-bleaching, and its reusability were also evaluated. The synthesized in situ MCM-MIP material should permit the detection of DPA for field assays related to suspect bacterial sporulation events. C1 [Smith, Clint B.; Anderson, John E.; Edwards, Jarrod D.] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. [Kam, Kinson C.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. RP Smith, CB (reprint author), USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. EM Clint.B.Smith@usace.army.mil FU U.S. Army Engineer Research and Development Center FX We would like to thank the U.S. Army Engineer Research and Development Center basic research program for funding this research opportunity. NR 29 TC 5 Z9 5 U1 0 U2 21 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD AUG PY 2011 VL 65 IS 8 BP 866 EP 875 DI 10.1366/10-06167 PG 10 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 798LD UT WOS:000293206800006 PM 21819776 ER PT J AU Knapik, JJ Steelman, R Grier, T Graham, B Hoedebecke, K Rankin, S Klug, K Proctor, S Jones, BH AF Knapik, Joseph J. Steelman, Ryan Grier, Tyson Graham, Bria Hoedebecke, Kyle Rankin, Shawn Klug, Kevin Proctor, Stanley Jones, Bruce H. TI Military Parachuting Injuries, Associated Events, and Injury Risk Factors SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE wind speed; night; combat loads; temperature; aircraft; drop zone; entanglements ID ANKLE BRACE; LANDING INJURIES; NORTH-CAROLINA; FORT-BRAGG; JUMPS; BATTALION; ALTITUDE; SCHOOL AB KNAPIK JJ, STEELMAN R, CRIER T, GRAHAM B, HOEDEBECKE K, RANKIN S, KLUG K, PROCTOR S, JONES BH. Military parachuting injuries, associated events, and injury risk factors. Aviat Space Environ Med 2011; 82:797-804. Introduction: The purpose of this investigation was to examine injury incidence, events associated with injury, and injury risk factors during parachuting in an Army airborne infantry unit. Methods: Injury data were obtained by the investigators on the drop zone and confirmed by a physician. Operational data (potential injury risk factors) were obtained from routine reports published by the infantry unit. Weather data were obtained using a Kestrel (R) Model 4500 pocket weather tracker. Results: There were a total of 23,031 jumps resulting in 242 injured soldiers for a crude injury incidence of 10.5 per 1000 jumps. Parachute entanglement incidence was 0.5 per 1000 jumps. Where an event associated with the injury could be determined (67% of cases), these included ground impact (75%), static line problems (11%), tree landings (4%), entanglements (4%), and aircraft exits (3%). Univariate analysis showed that higher injury risk was associated with night jumps (versus day jumps), combat loads (versus unloaded jumps), higher wind speeds, higher dry bulb temperatures, higher humidity, C17 Globemaster or C130 Hercules aircrafts (compared to the other aircraft), exits through aircraft side doors (versus tailgates), and entanglements. Multivariate analysis indicated that independent risk factors for injuries included night jumps, combat loads, higher wind speeds, higher dry bulb temperatures, and entanglements. Discussion: This investigation provided injury incidence, events associated with injury, and quantitative assessments of injury risk factors and their interactions during military parachuting. An appreciation of these subjects can assist medical and operational planners in further reducing the incidence of injury during airborne operations. C1 [Hoedebecke, Kyle] Womack Army Med Ctr, Ft Bragg, NC USA. [Rankin, Shawn; Klug, Kevin; Proctor, Stanley] Concurrent Technol Corp, Fayetteville, NC USA. USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA. RP Knapik, JJ (reprint author), USA, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command Prov, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@apg.amedd.army.mil FU Office of the Assistant Secretary of the Army (Installations, Energy and Environment) [W74V8H-04-D-0005, 0517] FX The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision, unless so designated by other official documentation. This work was funded through the Office of the Assistant Secretary of the Army (Installations, Energy and Environment) and conducted under contract W74V8H-04-D-0005 Task 0517. NR 35 TC 6 Z9 10 U1 0 U2 6 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2011 VL 82 IS 8 BP 797 EP 804 DI 10.3357/ASEM.3061.2011 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 797TK UT WOS:000293152800006 PM 21853858 ER PT J AU Mancuso, JD Tribble, D Mazurek, GH Li, YZ Olsen, C Aronson, NE Geiter, L Goodwin, D Keep, LW AF Mancuso, James D. Tribble, David Mazurek, Gerald H. Li, Yuanzhang Olsen, Cara Aronson, Naomi E. Geiter, Lawrence Goodwin, Donald Keep, Lisa W. TI Impact of Targeted Testing for Latent Tuberculosis Infection Using Commercially Available Diagnostics SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID RISK ASSESSMENT QUESTIONNAIRE; GAMMA RELEASE ASSAYS; NEW-YORK-CITY; SKIN-TEST; MYCOBACTERIUM-TUBERCULOSIS; UNITED-STATES; PREVALENCE; CONTACT; CHILDREN; MODEL AB Background. The interferon-gamma release assays (IGRAs) are increasingly being used as an alternative to the tuberculin skin test (TST). Although IGRAs may have better specificity and certain logistic advantages to the TST, their use may contribute to overtesting of low-prevalence populations if testing is not targeted. The objective of this study was to evaluate the accuracy of a risk factor questionnaire in predicting a positive test result for latent tuberculosis infection using the 3 commercially available diagnostics. Methods. A cross-sectional comparison study was performed among recruits undergoing Army basic training at Fort Jackson, South Carolina, from April through June 2009. The tests performed included: (1) a risk factor questionnaire; (2) the QuantiFERON Gold In-Tube test (Cellestis Limited, Carnegie, Victoria, Australia); (3) the T-SPOT. TB test (Oxford Immunotec Limited, Abingdon, United Kingdom); and (4) the TST (Sanofi Pasteur Ltd., Toronto, Ontario, Canada). Prediction models used logistic regression to identify factors associated with positive test results. RFQ prediction models were developed independently for each test. Results. Use of a 4-variable model resulted in 79% sensitivity, 92% specificity, and a c statistic of 0.871 in predicting a positive TST result. Targeted testing using these risk factors would reduce testing by >90%. Models predicting IGRA outcomes had similar specificities as the skin test but had lower sensitivities and c statistics. Conclusions. As with the TST, testing with IGRAs will result in false-positive results if the IGRAs are used in low-prevalence populations. Regardless of the test used, targeted testing is critical in reducing unnecessary testing and treatment. C1 [Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Residency Program, Div Prevent Med, Silver Spring, MD 20910 USA. [Mancuso, James D.; Tribble, David; Olsen, Cara; Keep, Lisa W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Aronson, Naomi E.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Geiter, Lawrence] Otsuka Pharmaceut Co Ltd, TB Prod Unit, Rockville, MD USA. [Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Goodwin, Donald] USAF, Sch Aerosp Med, Brooks City Base, TX USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU Uniformed Services University of the Health Sciences; US Army Public Health Command [IDCRP-021]; Infectious Diseases Clinical Research Program (IDCRP) [IDCRP-021]; medical and installation leadership at Fort Jackson; National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency [Y1-AI-5072] FX This study would not have been possible without financial and other support of the Uniformed Services University of the Health Sciences, the US Army Public Health Command, the Infectious Diseases Clinical Research Program, the medical and installation leadership at Fort Jackson, and the Soldiers who participated in the study.; This study (IDCRP-021) was supported by both the US Army Public Health Command and the Infectious Disease Clinical Research Program (IDCRP). The IDCRP is a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded, in whole or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. NR 29 TC 11 Z9 11 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 1 PY 2011 VL 53 IS 3 BP 234 EP 244 DI 10.1093/cid/cir321 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 796BK UT WOS:000293025000004 PM 21765072 ER PT J AU Dobson, CP La Rovere, MT Pinna, GD Goldstein, R Olsen, C Bernardinangeli, M Veniani, M Midi, P Tavazzi, L Haigney, M AF Dobson, Craig P. La Rovere, Maria Teresa Pinna, Gian Domenico Goldstein, Robert Olsen, Cara Bernardinangeli, Marino Veniani, Marco Midi, Paolo Tavazzi, Luigi Haigney, Mark CA GISSI-HF Investigators TI QT variability index on 24-hour Holter independently predicts mortality in patients with heart failure: analysis of Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca (GISSI-HF) trial SO HEART RHYTHM LA English DT Article DE Repolarization; QT; U wave; QT variability; cardiovascular mortality; heart failure ID TO-BEAT VARIABILITY; INTERVAL VARIABILITY; WAVE ALTERNANS; REPOLARIZATION; DEFIBRILLATOR; DEATH AB BACKGROUND Increased temporal variability of repolarization, as reflected by QT interval variability measured over 10-15 minutes, predicted spontaneous ventricular arrhythmias and death in implantable cardioverter-defibrillator patients in mild to moderate heart failure (HF). OBJECTIVE The purpose of this study was to test our hypothesis that increased mean QT variability over 24 hours would be associated with increased cardiovascular (CV) mortality in a heterogeneous HF population. METHODS The Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure trial prospectively enrolled subjects with HF of any cause. Twenty-four-hour Holter recordings from 268 subjects were analyzed using a template-matching, semiautomatic algorithm to measure QT and heart rate time series in sequential 5-minute epochs over 24 hours. The QT variability index (QTVI) was expressed as the log ratio of the normalized QT variance over normalized heart rate variance. Total and CV mortality were assessed as a function of continuous and dichotomous QTVI (>-0.84) in univariate and multivariable Cox proportional hazards models, adjusting for significant clinical predictors. RESULTS After a median of 47 months, there were 53 deaths, of which 44 were from CV causes. A significant association with the outcome was found for QTVI both as continuous and dichotomous variables after adjustment for clinical covariates (age > 70, New York Heart Association class III-IV, left ventricular ejection fraction, non-sustained ventricular tachycardia, creatinine): QTVI hazard ratio (HR) 4.0 (confidence interval [CI] 1.8-88; P = .008) for total and 4.4 (CI 1.9-10.1; P = .0006) for CV mortality; QTVI >-0.84 HR 2.0 (CI 1.1-3.6; P = .02) for total and 2.1 (CI 1.1-3.8; P = .02) for CV mortality. CONCLUSION Increased repolarization lability, as reflected in QTVI measured over 24 hours, is associated with increased risk for total and CV mortality in a heterogeneous population with chronic HF. C1 [Haigney, Mark] Uniformed Serv Univ Hlth Sci, Div Cardiol, Dept Med, Bethesda, MD 20814 USA. [Dobson, Craig P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [La Rovere, Maria Teresa; Pinna, Gian Domenico] S Maugeri Fdn, IRCCS, Sci Inst Montescano, Pavia, Italy. [Bernardinangeli, Marino] Azienda Unita Sanit Locale 4, Terni, Italy. [Veniani, Marco] Osped Civile, Milan, Italy. [Midi, Paolo] Osped Civile S Giuseppe, Rome, Italy. [Tavazzi, Luigi] Grp Villa Maria Hosp Care & Res, Cotignola, Ravenna, Italy. RP Haigney, M (reprint author), Uniformed Serv Univ Hlth Sci, Div Cardiol, Dept Med, A3060,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mhaigney@usuhs.edu NR 20 TC 19 Z9 21 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1547-5271 J9 HEART RHYTHM JI Heart Rhythm PD AUG PY 2011 VL 8 IS 8 BP 1237 EP 1242 DI 10.1016/j.hrthm.2011.03.055 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 795XX UT WOS:000293013600018 PM 21457791 ER PT J AU Kamau, E Tolbert, LS Kortepeter, L Pratt, M Nyakoe, N Muringo, L Ogutu, B Waitumbi, JN Ockenhouse, CF AF Kamau, Edwin Tolbert, LaDonna S. Kortepeter, Luke Pratt, Michael Nyakoe, Nancy Muringo, Linda Ogutu, Bernard Waitumbi, John N. Ockenhouse, Christian F. TI Development of a Highly Sensitive Genus-Specific Quantitative Reverse Transcriptase Real-Time PCR Assay for Detection and Quantitation of Plasmodium by Amplifying RNA and DNA of the 18S rRNA Genes SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MALARIA; FALCIPARUM; DIAGNOSIS; VIVAX; MOSQUITO AB A highly sensitive genus-specific quantitative reverse transcriptase real-time PCR (qRT-PCR) assay for detection of Plasmodium has been developed. The assay amplifies total nucleic acids (RNA and DNA) of the 18S rRNA genes with a limit of detection of 0.002 parasite/mu l using cultured synchronized ring stage 3D7 parasites. Parasite densities as low as 0.000362 parasite/mu l were detected when analyzing clinical samples. Analysis of clinical samples showed that detection of 18S rRNA genes from total nucleic acids increased the analytical sensitivity of the assay by more than 1 log unit compared to DNA only. When clinical samples with no parasites present by microscopy were analyzed by qRT-PCR, 90% (117 of 130) were positive for the presence of Plasmodium nucleic acids. Quantification of clinical samples by qRT-PCR using total nucleic acid versus DNA was compared to microscopy. There was a significantly greater correlation of parasite density to microscopy when DNA alone was used than with total nucleic acid. We conclude that analysis of total nucleic acids by qRT-PCR is a suitable assay for detection of low parasite levels in patients with early-stage malaria and/or submicroscopic infections and could greatly benefit malaria diagnosis, intervention trials, and malaria control and elimination efforts. C1 [Kamau, Edwin] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Ctr Mol Diagnost & Genom Studies, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Tolbert, LaDonna S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Nyakoe, Nancy; Muringo, Linda; Ogutu, Bernard; Waitumbi, John N.] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Ctr Mol Diagnost & Genom Studies, US Mil Malaria Vaccine Program, 503 Robert Grant Ave, Silver Spring, MD USA. EM Edwin.kamau@us.army.mil NR 22 TC 59 Z9 61 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 2011 VL 49 IS 8 BP 2946 EP 2953 DI 10.1128/JCM.00276-11 PG 8 WC Microbiology SC Microbiology GA 798PE UT WOS:000293221900026 PM 21653767 ER PT J AU Cain, N Haywood, A Roberts, G Kiserow, D Carbonell, R AF Cain, Nathaniel Haywood, Alexander Roberts, George Kiserow, Douglas Carbonell, Ruben TI Polystyrene/Decahydronaphthalene/Propane Phase Equilibria and Polymer Conformation Properties from Intrinsic Viscosities SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE conformational analysis; decahydronaphthalene; intrinsic viscosity; miscibility; phase behavior; phase diagrams; phase separation; polystyrene; viscosity ID SUPERCRITICAL CARBON-DIOXIDE; DILUTE-SOLUTION PROPERTIES; LIQUID-LIQUID EQUILIBRIA; LIGHT-SCATTERING; HIGH-PRESSURE; OVERLAP CONCENTRATION; POLYSTYRENE SOLUTIONS; BEHAVIOR; PROPANE; SOLVENTS AB The influence of dissolved propane (up to 31.2 wt %) on the phase equilibria of 5 wt % polystyrene (PS) dissolved in 66/34 wt % trans/cis-decahydronaphthalene (DHN) was measured over the temperature range of 323-423 K. A suitable temperature, pressure, and propane composition operating space was defined to measure intrinsic viscosities of a single fluid phase. Intrinsic viscosities of PS in cosolvent mixtures of propane and trans/cis-DHN were measured between 323 and 423 K and between 70 and 208 bar. The addition of propane to the isomeric mixture of DHN resulted in a decreased solvent quality for PS, causing a contraction of the PS coil. The most dramatic decrease in solvent quality with the addition of propane occurred at 323 K and 70 bar with approximately a 36% reduction in the viscometric radius with the addition of 45 mol % propane to DHN. At 423 K, the solvent quality was less sensitive to the addition of propane and only a 13% reduction in the viscometric radius was observed at 70 bar and 45 mol % propane in DHN. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 1093-1100, 2011 C1 [Cain, Nathaniel; Haywood, Alexander; Roberts, George; Kiserow, Douglas; Carbonell, Ruben] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27606 USA. [Kiserow, Douglas] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Carbonell, R (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, 1017 Main Campus Dr,Partners Bldg 1,Suite 3200,Bo, Raleigh, NC 27606 USA. EM ruben@ncsu.edu FU National Science Foundation [9876674] FX This research was funded by the National Science Foundation agreement # 9876674. The authors thank G. Huvard and M. McHugh for helpful suggestions with the design of the phase equilibria apparatus and phase equilibria measurements. The authors thank Brandon Lisk of 101 Machine for aiding in the construction and design of the phase equilibria and viscometer apparatus. NR 32 TC 2 Z9 2 U1 0 U2 14 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD AUG 1 PY 2011 VL 49 IS 15 BP 1093 EP 1100 DI 10.1002/polb.22282 PG 8 WC Polymer Science SC Polymer Science GA 799IA UT WOS:000293279100003 ER PT J AU Wolf, JM Cameron, KL Owens, BD AF Wolf, Jennifer Moriatis Cameron, Kenneth L. Owens, Brett D. TI Impact of Joint Laxity and Hypermobility on the Musculoskeletal System SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review ID ANTERIOR CRUCIATE LIGAMENT; EHLERS-DANLOS-SYNDROME; INFERIOR CAPSULAR-SHIFT; MULTIDIRECTIONAL INSTABILITY; FIBROMYALGIA SYNDROME; SHOULDER INSTABILITY; HAND OSTEOARTHRITIS; DERMAL COLLAGEN; ELASTIC FIBERS; RISK-FACTORS AB Excessive joint laxity, or hypermobility, is a common finding of clinical importance in the management of musculoskeletal conditions. Hypermobility is common in young patients and in general is associated with an increased incidence of musculoskeletal injury. Hypermobility has been implicated in ankle sprains, anterior cruciate ligament injury, shoulder instability, and osteoarthritis of the hand. Patients with hypermobility and musculoskeletal injuries often seek care for diffuse musculoskeletal pain and injuries with no specific inciting event. Orthopaedic surgeons and other healthcare providers should be aware of the underlying relationship between hypermobility and musculoskeletal injury to avoid unnecessary diagnostic tests and inappropriate management. Prolonged therapy and general conditioning are typically required, with special emphasis on improving strength and proprioception to address symptoms and prevent future injury. Orthopaedic surgeons must recognize the implications of joint mobility syndromes in the management and rehabilitation of several musculoskeletal injuries and orthopaedic disorders. C1 [Wolf, Jennifer Moriatis] Univ Colorado Denver, Dept Orthopaed, Aurora, CO USA. [Cameron, Kenneth L.; Owens, Brett D.] Keller Army Hosp, West Point, NY USA. RP Wolf, JM (reprint author), Univ Colorado Denver, Dept Orthopaed, Aurora, CO USA. FU SLACK; Elsevier; Journal of Hand Surgery American; Musculoskeletal Transplant Foundation FX Dr. Wolf or an immediate family member serves as a board member, owner, officer, or committee member of the American Association for Hand Surgery, the American Society for Surgery of the Hand, and the American Academy of Orthopaedic Surgeons; and has received royalties from SLACK, Elsevier, and the Journal of Hand Surgery American. Dr. Cameron or an immediate family member serves as a paid consultant to or is an employee of the Musculoskeletal Transplant Foundation. Dr. Owens or an immediate family member serves as a board member, owner, officer, or committee member of the American Academy of Orthopaedic Surgeons, the American Orthopaedic Society for Sports Medicine, and the Society of Military Orthopaedic Surgeons. NR 75 TC 27 Z9 27 U1 7 U2 32 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD AUG PY 2011 VL 19 IS 8 BP 463 EP 471 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 799SF UT WOS:000293305700002 PM 21807914 ER PT J AU Natesan, S Wrice, NL Baer, DG Christy, RJ AF Natesan, Shanmugasundaram Wrice, Nicole L. Baer, David G. Christy, Robert J. TI Debrided Skin as a Source of Autologous Stem Cells for Wound Repair SO STEM CELLS LA English DT Article DE Debrided skin; Adipose stem cells; Burn wounds; Perivascular niche ID HUMAN ADIPOSE-TISSUE; OPERATION IRAQI FREEDOM; STROMAL CELLS; IN-VITRO; PERIVASCULAR PHENOTYPE; GENE-EXPRESSION; DIFFERENTIATION; SURFACE; SECRETION; ADIPOCYTE AB Major traumatic injuries to the body, such as large surface area burns, limit the availability of autologous stem cell populations for wound repair. This report demonstrates that even after severe burn trauma to the body, resident stem cells present within the subcutaneous adipose tissue survive and are available for therapeutic uses. Debrided skin from wounded areas contains subcutaneous adipose tissue and can yield approximately 1.5 x 10(5) to 2.5 x 10(5) cells per milliliter of tissue. This observation indicates that tissue, which is normally discarded, could be a valuable source of stem cells. Initial immunohistochemistry of the debrided tissue localized platelet-derived growth factor receptor beta(+) (PDGFR-beta(+)) cells to perivascular niches of vascular beds. It was immunophenotypically confirmed that the cell isolates are stem cells and designated as debrided skin adipose-derived stem cells (dsASCs). Gene expression analysis of stem cell specific transcripts showed that the dsASCs maintained their stemness over serial passages. Furthermore, dsASCs were able to differentiate into adipogenic, osteogenic, and vascular cell lineages. Finally, an in vivo excision wound model in athymic rats demonstrated that the dsASCs are engrafted within a wound bed after 12 days. These data provide the first evidence that subcutaneous adipose tissue from discarded burned skin contains a viable population of stem cells that can be used for wound repair and skin regenerative therapies. STEM CELLS 2011; 29: 1219-1230 C1 [Natesan, Shanmugasundaram; Wrice, Nicole L.; Baer, David G.; Christy, Robert J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Christy, RJ (reprint author), USA, Inst Surg Res, 3698 Chambers Pass,Bldg 3611-BHT1, Ft Sam Houston, TX 78234 USA. EM robert.christy@us.army.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU University of Texas Health Science Center at San Antonio; NIH (Cancer Therapy & Research Center) [NCI P30 CA054174]; Pittsburgh Tissue Engineering Initiative (PTEI); U.S. Army Medical Research and Materiel Command FX We thank Cpt. Laura McGhee and Thomas Garza for collection of debrided tissue; Col. Seung Kim and Ltc. Scot J. Estep for their valuable suggestions and histopathological analysis of human and rat tissues samples; Dr. Shanmuganathan Seetharaman, Dr. David Zamora, Janet Roe, and Sharanda Hardy for their technical support; and Karla Moncada for providing technical support at the cell sorting core facility. This work was supported by the University of Texas Health Science Center at San Antonio and NIH Grant NCI P30 CA054174 (Cancer Therapy & Research Center). S.N. is supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative (PTEI). This research was funded by the U.S. Army Medical Research and Materiel Command. NR 58 TC 24 Z9 26 U1 0 U2 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1066-5099 J9 STEM CELLS JI Stem Cells PD AUG PY 2011 VL 29 IS 8 BP 1219 EP 1230 DI 10.1002/stem.677 PG 12 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Oncology; Cell Biology; Hematology SC Cell Biology; Biotechnology & Applied Microbiology; Oncology; Hematology GA 797NF UT WOS:000293133900007 PM 21674701 ER PT J AU Hjelkrem, MC Harrison, SA AF Hjelkrem, M. C. Harrison, S. A. TI Do we need a histological score to diagnose non-alcoholic steatohepatitis? authors' reply SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Letter ID FATTY LIVER-DISEASE; VALIDATION C1 [Hjelkrem, M. C.; Harrison, S. A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Hjelkrem, MC (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 6 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-2813 J9 ALIMENT PHARM THER JI Aliment. Pharmacol. Ther. PD AUG PY 2011 VL 34 IS 4 BP 495 EP 496 DI 10.1111/j.1365-2036.2011.04751.x PG 2 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 793ZF UT WOS:000292862300012 ER PT J AU Hanna, S White, J Trolier, J Vernot, R Brown, M Gowardhan, A Kaplan, H Alexander, Y Moussafir, J Wang, YS Williamson, C Hannan, J Hendrick, E AF Hanna, Steven White, John Trolier, James Vernot, Rebecca Brown, Michael Gowardhan, Akshay Kaplan, Hadassah Alexander, Yehuda Moussafir, Jacques Wang, Yansen Williamson, Chatt Hannan, John Hendrick, Elizabeth TI Comparisons of JU2003 observations with four diagnostic urban wind flow and Lagrangian particle dispersion models SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Urban dispersion models; Urban wind flow; JU2003 ID OKLAHOMA-CITY; MANHATTAN; SIMULATIONS AB Urban wind flow and dispersion models are needed that can satisfactorily account for the effects of the three-dimensional (3D) building geometries but which run much faster than Computational Fluid Dynamics (CFD) models. With sufficient speed, the models can be used for rapid response and for applications where many simulations must be performed in a short time period. To satisfy this need, several diagnostic wind flow models have been developed for urban areas, where mass-consistent principles are used in combination with local wind observations to solve for the mean wind flow on domains of size ranging from a few hundred meters to several kilometers on a side, within which detailed 3-D building geometries are defined. Simple assumptions about vortex flow structures are parameterized near buildings and in street canyons. The wind flow results are used as inputs to a Lagrangian particle dispersion model (LPDM), where the needed turbulent velocities and time scales are parameterized using standard boundary layer profile formulas combined with special relations around buildings. As part of a collaborative study, with the intent of advancing each model, the developers of four of these models have run their models for two tracer releases (one daytime and one nighttime) during the Joint Urban 2003 (JU2003) field experiment. The four models are: QUIC by Los Alamos National Laboratory (LANL), 3DWF by the Army Research Laboratory, the urban Lagrangian model by the Israel Institute for Biological Research (IIBR), and Microswift/Spray (MSS) by Aria Technologies and SAIC. The comparison uses nearly identical domains and grid systems, and all models use the same input wind profile. The simulated patterns of wind fields and tracer contours are in good qualitative agreement. For wind speed near the surface, the mean model biases are less than about 20% and RMS errors are about 1-2 m s(-1). For tracer concentrations, the four models give similar quantitative results, where the mean relative biases suggest that the individual models can be sometimes as much as a factor of two high or low, and where the scatter suggests that, for all models, about 30 or 40% of the simulations are within a factor of two of observations. In most cases, the observed plume is broader than the simulated plume, and the models are biased toward slight underestimation of the dispersion of the plumes to the tall rooftops. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Hanna, Steven] Hanna Consultants, Kennebunkport, ME USA. [White, John] USA, Test & Evaluat Command, Dugway Proving Ground, UT USA. [Trolier, James; Vernot, Rebecca] Sci Applicat Int Corp, Allentown, PA USA. [Brown, Michael; Gowardhan, Akshay] Los Alamos Natl Lab, Los Alamos, NM USA. [Kaplan, Hadassah; Alexander, Yehuda] IIBR, Tel Aviv, Israel. [Moussafir, Jacques] ARIA Tech, Paris, France. [Wang, Yansen; Williamson, Chatt] USA, Res Lab, Adelphi, MD USA. [Hannan, John] US Def Threat Reduct Agcy, Alexandria, VA USA. [Hendrick, Elizabeth] Epsilon Assoc, Maynard, MA USA. RP Hanna, S (reprint author), Hanna Consultants, Kennebunkport, ME USA. EM hannaconsult@roadrunner.com OI Brown, Michael J./0000-0002-8069-0835 FU U.S. Defense Threat Reduction Agency (DTRA); LANL; U.S. Army Research Laboratory FX This research was supported by the U.S. Defense Threat Reduction Agency (DTRA). We appreciate the assistance of Rick Fry and Chris Kiley of DTRA. John White of the U.S. Army Dugway Proving Ground provided the JU2003 data archive that was used, as well as specialized plots of meteorological inputs. The QUIC model runs were supported by LANL, the 3DWF model runs were supported by the U.S. Army Research Laboratory, and the IIBR model runs were supported by that agency. NR 33 TC 13 Z9 13 U1 2 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD AUG PY 2011 VL 45 IS 24 BP 4073 EP 4081 DI 10.1016/j.atmosenv.2011.03.058 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 796IU UT WOS:000293045800018 ER PT J AU Antonarakis, ES Chen, YM Elsamanoudi, SI Brassell, SA Da Rocha, MV Eisenberger, MA McLeod, DG AF Antonarakis, Emmanuel S. Chen, Yongmei Elsamanoudi, Sally I. Brassell, Stephen A. Da Rocha, Mario V. Eisenberger, Mario A. McLeod, David G. TI Long-term overall survival and metastasis-free survival for men with prostate-specific antigen-recurrent prostate cancer after prostatectomy: analysis of the Center for Prostate Disease Research National Database SO BJU INTERNATIONAL LA English DT Article DE metastasis-free survival; natural history; overall survival; prostate cancer; PSA recurrence ID RADICAL RETROPUBIC PROSTATECTOMY; BIOCHEMICAL RECURRENCE; RADIATION-THERAPY; MORTALITY; FAILURE; RADIOTHERAPY; PROGRESSION; MANAGEMENT; FLUTAMIDE; OUTCOMES AB OBJECTIVE To describe metastasis-free survival (MFS) and overall survival (OS) among men with prostate-specific antigen (PSA)-recurrent prostate cancer after radical prostatectomy who did not receive additional therapy until metastasis, using a multicentre database capturing a wide ethnic mix. PATIENTS AND METHODS A retrospective analysis of the Center for Prostate Disease Research National Database (comprised of five US military hospitals and one civilian centre) was performed for patients with PSA relapse (>= 0.2 ng/mL) after radical prostatectomy who had no additional therapy until the time of radiographic metastatic disease. We investigated factors influencing metastasis and all-cause mortality using univariate and multivariate Cox regression analysis. RESULTS There were a total of 346 men who underwent radical prostatectomy between May 1983 and November 2008 and fulfilled the entry criteria. All patients had information on survival and 190 men had information on metastasis. Among patients with survival data (n = 346), 10-year OS was 79% after a median follow-up of 8.6 years from biochemical recurrence. Among men with metastasis data (n = 190), 10-year MFS was 46% after a median follow-up of 7.5 years. In Cox regressions, four clinical factors (Gleason score, pathological stage, time to PSA relapse and PSA doubling time), as well as age, were predictive of OS and/or MFS in univariate analysis, although only PSA doubling time (>= 9 vs 3-8.9 vs < 3 months) remained independently predictive of these outcomes in multivariate analysis (P < 0.001). CONCLUSIONS This multicentre multi-ethnic dataset shows that OS and MFS can be extensive for men with PSA-recurrent prostate cancer, even in the absence of further therapy before metastasis. This unique patient cohort, the second largest of its type after the Johns Hopkins cohort, confirms that PSA doubling time is the strongest determinant of OS and MFS in men with PSA-recurrent disease. Longer follow-up and more events will be required to determine whether other variables may also contribute to these outcomes. C1 [Antonarakis, Emmanuel S.; Eisenberger, Mario A.] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA. [Chen, Yongmei; Elsamanoudi, Sally I.; Brassell, Stephen A.; Da Rocha, Mario V.; McLeod, David G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Antonarakis, ES (reprint author), Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Prostate Canc Res Program, 1650 Orleans St,CRB1-1M45, Baltimore, MD 21231 USA. EM eantona1@jhmi.edu RI Antonarakis, Emmanuel/E-4550-2011 FU Department of Defense; Congressional Special Interest (CSI) biomedical research programme FX None declared. Source of Funding: the present study was supported by the Department of Defense and the Congressional Special Interest (CSI) biomedical research programme. NR 31 TC 30 Z9 31 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1464-4096 J9 BJU INT JI BJU Int. PD AUG PY 2011 VL 108 IS 3 BP 378 EP 385 DI 10.1111/j.1464-410X.2010.09878.x PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 795WE UT WOS:000293007800019 PM 21091976 ER PT J AU Mikolajczak, SA Sacci, JB De La Vega, P Camargo, N VanBuskirk, K Krzych, U Cao, J Jacobs-Lorena, M Cowman, AF Kappe, SHI AF Mikolajczak, Sebastian A. Sacci, John B., Jr. De La Vega, Patricia Camargo, Nelly VanBuskirk, Kelly Krzych, Urszula Cao, Jun Jacobs-Lorena, Marcelo Cowman, Alan F. Kappe, Stefan H. I. TI Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites SO CELLULAR MICROBIOLOGY LA English DT Article ID CHIMERIC HUMAN LIVERS; MALARIA PARASITES; SPOROZOITES; INFECTION; ESTABLISHMENT; TRANSMISSION; HEPATOCYTES; PROTECTION; RESPONSES; PROTEINS AB The malaria parasite Plasmodium falciparum infects humans and first targets the liver where liver-stage parasites undergo pre-erythrocytic replication. Liver-stage antigen-1 (LSA-1) is currently the only identified P. falciparum protein for which expression is restricted to liver stages. Yet, the importance of LSA-1 for liver-stage parasite development remains unknown. Here we deleted LSA-1 in the NF54 strain of P. falciparum and analysed the lsa-1(-) parasites throughout their life cycle. lsa-1(-) sporozoites had normal gliding motility and invasion into hepatocytes. Six days after infection of a hepatocytic cell line, lsa-1-parasites exhibited a moderate phenotype with an similar to 50% reduction of late liver-stage forms when compared with wild type. Strikingly, lsa-1-parasites growing in SCID/Alb-uPA mice with humanized livers showed a severe defect in late liver-stage differentiation and exo-erythrocytic merozoite formation 7 days after infection, a time point when wild-type parasites develop into mature merozoites. The lsa-1(-) parasites also showed aberrant liver-stage expression of key parasite proteins apical membrane antigen-1 and circumsporozoite protein. Our data show that LSA-1 plays a critical role during late liver-stage schizogony and is thus important in the parasite transition from the liver to blood. LSA-1 is the first P. falciparum protein identified to be required for this transitional stage of the parasite life cycle. C1 [Mikolajczak, Sebastian A.; Camargo, Nelly; VanBuskirk, Kelly; Kappe, Stefan H. I.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [Sacci, John B., Jr.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [De La Vega, Patricia; Krzych, Urszula] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Cao, Jun; Jacobs-Lorena, Marcelo] Johns Hopkins Univ, Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Cowman, Alan F.] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia. [Kappe, Stefan H. I.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. RP Kappe, SHI (reprint author), Seattle Biomed Res Inst, 4 Nickerson St, Seattle, WA 98109 USA. EM stefan.kappe@seattlebiomed.org RI Cowman, Alan/C-7642-2013; OI Cowman, Alan/0000-0001-5145-9004; Mikolajczak, Sebastian/0000-0003-1996-9703 FU Bill and Melinda Gates Foundation through the Foundation at the National Institutes of Health Grand Challenges in Global Health Initiative; US Department of Defense FX This work was supported by the Bill and Melinda Gates Foundation through the Foundation at the National Institutes of Health Grand Challenges in Global Health Initiative and the US Department of Defense. NR 38 TC 17 Z9 17 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1462-5814 J9 CELL MICROBIOL JI Cell Microbiol. PD AUG PY 2011 VL 13 IS 8 BP 1250 EP 1260 DI 10.1111/j.1462-5822.2011.01617.x PG 11 WC Cell Biology; Microbiology SC Cell Biology; Microbiology GA 793TI UT WOS:000292845700012 PM 21569184 ER PT J AU Gust, KA Brasfield, SM Stanley, JK Wilbanks, MS Chappell, P Perkins, EJ Lotufo, GR Lance, RF AF Gust, Kurt A. Brasfield, Sandra M. Stanley, Jacob K. Wilbanks, Mitchell S. Chappell, Pornsawan Perkins, Edward J. Lotufo, Guilherme R. Lance, Richard F. TI GENOMIC INVESTIGATION OF YEAR-LONG AND MULTIGENERATIONAL EXPOSURES OF FATHEAD MINNOW TO THE MUNITIONS COMPOUND RDX SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Toxicogenomics; RDX; Chronic exposure; Multigeneration exposure; Pimephales promelas ID BOBWHITE COLINUS-VIRGINIANUS; TRANSCRIPTIONAL-EFFECT-LEVEL; GENE-EXPRESSION; PIMEPHALES-PROMELAS; NORTHERN BOBWHITE; DAPHNIA-MAGNA; EXPLOSIVE COMPOUNDS; TOXICITY; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; CONSTITUENTS AB We assessed the impacts of exposure to an environmentally representative concentration (0.83 mg/L) of the explosive cyclotrimethylenetrinitramine (RDX) on fathead minnows (Pimephales promelas) in one-year and multigenerational bioassays. In the one-year bioassay, impacts were assessed by statistical comparisons of females from breeding groups reared in control or RDX-exposure conditions. The RDX had no significant effect on gonadosomatic index or condition factor assayed at 1 d and at one, three, six, nine, and 12 months. The liver-somatic index was significantly increased versus controls only at the 12-month timepoint. RDX had no significant effect on live-prey capture rates, egg production, or fertilization. RDX caused minimal differential-transcript expression with no consistent discernable effect on gene-functional categories for either brain or liver tissues in the one-year exposure. In the multigenerational assay, the effects of acute (96 h) exposure to RDX were compared in fish reared to the F-2 generation in either control or RDX-exposure conditions. Enrichment of gene functions including neuroexcitatory glutamate metabolism, sensory signaling, and neurological development were observed comparing control-reared and RDX-reared fish. Our results indicated that exposure to RDX at a concentration representing the highest levels observed in the environment (0.83 mg/L) had limited impacts on genomic, individual, and population-level endpoints in fathead minnows in a one-year exposure. However, multigenerational exposures altered transcript expression related to neural development and function. Environ. Toxicol. Chem. 2011;30:1852-1864. (C) 2011 SETAC C1 [Gust, Kurt A.; Brasfield, Sandra M.; Stanley, Jacob K.; Wilbanks, Mitchell S.; Perkins, Edward J.; Lotufo, Guilherme R.; Lance, Richard F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Chappell, Pornsawan] Bowhead Environm Lab, Vicksburg, MS USA. RP Gust, KA (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM kurt.a.gust@erdc.usace.army.mil FU U.S. Army Environmental Quality/Installations Basic Research Program FX This project received funding from the U.S. Army Environmental Quality/Installations Basic Research Program. The statistical consultation of J. Clarke and the technical support of W. Blackburn, J. Coleman, L. Escalon, J. Goss, D. Lindsay, and J. Williams is greatly appreciated. Permission was granted from the Chief of Engineers to publish this information. NR 48 TC 5 Z9 5 U1 0 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD AUG PY 2011 VL 30 IS 8 BP 1852 EP 1864 DI 10.1002/etc.558 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 796OH UT WOS:000293060900015 PM 21538488 ER PT J AU Karamian, SA Carroll, JJ Aksenov, NV Albin, YA Bozhikov, GA Dmitriev, SN Starodub, GY Vostokin, GK AF Karamian, S. A. Carroll, J. J. Aksenov, N. V. Albin, Y. A. Bozhikov, G. A. Dmitriev, S. N. Starodub, G. Y. Vostokin, G. K. TI Production of isomers in compound and transfer reactions with He-4 ions SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article DE Gamma spectroscopy; Compound nucleus; Transfer reactions; Isomer-to-ground-state ratio ID NUCLEAR-DATA SHEETS; TARGETS; TANTALUM; HAFNIUM; ENERGY; SPALLATION; PARTICLES; HF-178M2; RECOVERY; PROTONS AB A well-known island of nuclear isomerism appears near A = 175-180 due to the deformation alignment of single-particle orbits at high angular momentum. This sometimes results in the formation of multi-quasiparticle states with record spin that are long-lived because of "K-hindrance", i.e. symmetry rearrangement. Production methods and spectroscopic studies of these isomers remain a challenge for modern nuclear reaction and nuclear structure physics. In the present work, activities were produced by irradiation of Yb-176 (97.6% enriched) and Lu-nat targets with 35 MeV He-4 ions from the internal beam of the U-200 cyclotron. Induced activities were analyzed by applying the methods of radiochemistry and gamma spectroscopy. Yields of the compound and nucleon-transfer reactions were measured and the isomer-to-ground state ratios were deduced. Calculated results were obtained using standard procedures to reproduce the (alpha, xn) cross-sections, and the systematic behavior of the nucleon-transfer yields was established. The isomer-to-ground-state ratios for direct reactions with He-4 ions were examined, resulting in a new characterization of the reaction mechanism. Published by Elsevier B.V. C1 [Carroll, J. J.] Youngstown State Univ, Youngstown, OH 44555 USA. [Karamian, S. A.; Aksenov, N. V.; Albin, Y. A.; Bozhikov, G. A.; Dmitriev, S. N.; Starodub, G. Y.; Vostokin, G. K.] Joint Inst Nucl Res, Dubna 141980, Moscow Region, Russia. RP Carroll, JJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM karamian@nrmail.jinr.su; james.j.carroll2@us.army.mil FU DTRA [HDTRA1-08-1-0014] FX The authors gratefully acknowledge the U-200 cyclotron staff for the beam supply, and S.A.K. and J.J.C. acknowledge support by DTRA through Grant HDTRA1-08-1-0014. NR 36 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD AUG 1 PY 2011 VL 646 IS 1 BP 87 EP 94 DI 10.1016/j.nima.2011.03.010 PG 8 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 792AP UT WOS:000292713200008 ER PT J AU Zahn, CM Rao, LKF Olsen, C Whitworth, SA Washington, A Crothers, BA AF Zahn, Christopher M. Rao, Luigi K. F. Olsen, Cara Whitworth, Scott A. Washington, Antoine Crothers, Barbara A. TI Reproducibility of Endocervical Curettage Diagnoses SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID CERVICAL INTRAEPITHELIAL NEOPLASIA; P16(INK4A) IMMUNOHISTOCHEMISTRY IMPROVES; ELECTROSURGICAL EXCISION PROCEDURE; 2006 CONSENSUS GUIDELINES; CONE BIOPSY; INTEROBSERVER VARIATION; GYNECOLOGIC PATHOLOGISTS; PRETERM BIRTH; PREGNANCY; CONIZATION AB OBJECTIVE: To estimate overall interobserver variability of histopathology diagnoses on endocervical curettage (ECC) specimens. METHODS: Five study pathologists, blinded to the original diagnosis, reviewed archived ECC specimens initially interpreted as normal, low-grade dysplasia, and high-grade dysplasia. We assessed interobserver agreement and agreement between pathologists using the kappa statistic and analyzed the effect of reducing diagnostic choices to two categories (one method using "normal and dysplasia" and another method using "normal and low-grade" and "high-grade or worse"). RESULTS: A total of 90 specimens were reviewed. The overall observer agreement was moderate (kappa=0.52). For specific diagnoses, cases interpreted as normal or high-grade dysplasia demonstrated greater agreement than those interpreted as low-grade dysplasia. Individual pathologists' comparison kappa values ranged from 0.31 to 0.80. Changing diagnostic options to a two-tiered system resulted in significant improvement in kappa values for only 1 of 36 pathologist comparisons. Using the gynecologist pathologist consensus interpretation, study pathologists downgraded 44% of cases originally interpreted as high-grade. CONCLUSION: Interobserver agreement in the interpretation of ECC specimens is at best moderate, even between those with additional experience and training in gynecologic pathology. Furthermore, reducing diagnostic options to two categories did not improve agreement. It is concerning that important clinical decisions may be made based on an ECC diagnosis that is moderately or poorly reproducible. (Obstet Gynecol 2011;118:240-8) DOI: 10.1097/AOG.0b013e318223552d C1 [Zahn, Christopher M.] USUHS, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Natl Naval Med Ctr, Dept Pathol, Bethesda, MD USA. USUHS, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Zahn, CM (reprint author), USUHS, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM czahn@usuhs.mil NR 34 TC 5 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 2011 VL 118 IS 2 BP 240 EP 248 DI 10.1097/AOG.0b013e318223552d PN 1 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 795FB UT WOS:000292956900007 PM 21775838 ER PT J AU Choksi, KB Nuss, JE DeFord, JH Papaconstantinou, J AF Choksi, Kashyap B. Nuss, Jonathan E. DeFord, James H. Papaconstantinou, John TI Mitochondrial electron transport chain functions in long-lived Ames dwarf mice SO AGING-US LA English DT Article DE Aging; Ames dwarf mice; longevity; mitochondrial function; electron transport chain activity; oxidative stress ID OXIDATIVELY DAMAGED PROTEINS; AGE-RELATED ALTERATIONS; LIFE-SPAN; AGING-PROCESS; CALORIC RESTRICTION; STRESS RESISTANCE; MOUSE MODELS; IN-VIVO; COMPLEXES; LONGEVITY AB The age-associated decline in tissue function has been attributed to ROS-mediated oxidative damage due to mitochondrial dysfunction. The long-lived Ames dwarf mouse exhibits resistance to oxidative stress, a physiological characteristic of longevity. It is not known, however, whether there are differences in the electron transport chain ( ETC) functions in Ames tissues that are associated with their longevity. In these studies we analyzed enzyme activities of ETC complexes, CI-CV and the coupled CI-CII and CII-CIII activities of mitochondria from several tissues of young, middle aged and old Ames dwarf mice and their corresponding wild type controls to identify potential mitochondrial prolongevity functions. Our studies indicate that post-mitotic heart and skeletal muscle from Ames and wild-type mice show similar changes in ETC complex activities with aging, with the exception of complex IV. Furthermore, the kidney, a slowly proliferating tissue, shows dramatic differences in ETC functions unique to the Ames mice. Our data show that there are tissue specific mitochondrial functions that are characteristic of certain tissues of the long-lived Ames mouse. We propose that this may be a factor in the determination of extended lifespan of dwarf mice. C1 [DeFord, James H.; Papaconstantinou, John] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA. [Choksi, Kashyap B.] Univ Texas Med Branch, Dept Med, Galveston, TX 77555 USA. [Nuss, Jonathan E.] USA, Res Inst Infect Dis, Ft Dietrich, MD USA. RP Papaconstantinou, J (reprint author), Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA. EM jpapacon@utmb.edu RI Papaconstantinou, John/E-3312-2010 FU U.S.P.H.S; National Institute on Aging [1P01 AG021830, 1 P30 AG024832-03]; Sealy Center on Aging; Kempner Foundation; National Institutes of Environmental Health Sciences [T32-07254] FX This publication was supported by U.S.P.H.S. grant 1P01 AG021830 awarded by the National Institute on Aging; the National Institute on Aging 1 P30 AG024832-03 Claude D. Pepper Older Americans Independence Center grant, and by the Sealy Center on Aging. J.E.N. would like to thank the Kempner Foundation and the National Institutes of Environmental Health Sciences Training Grant (T32-07254) for additional fellowship support. NR 54 TC 13 Z9 14 U1 0 U2 1 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1945-4589 J9 AGING-US JI Aging-US PD AUG PY 2011 VL 3 IS 8 BP 754 EP 767 PG 14 WC Cell Biology SC Cell Biology GA 845BG UT WOS:000296797200007 PM 21934186 ER PT J AU Hadamitzky, M Al-Mallah, M Berman, D Cademartiri, F Chang, HJ Chow, B Kaufmann, P Min, J Villines, T Hausleiter, J AF Hadamitzky, M. Al-Mallah, M. Berman, D. Cademartiri, F. Chang, H. J. Chow, B. Kaufmann, P. Min, J. Villines, T. Hausleiter, J. TI A novel prognostic score using coronary CT angiography significantly improves risk prediction beyond standard risk factors SO EUROPEAN HEART JOURNAL LA English DT Meeting Abstract C1 [Hadamitzky, M.; Hausleiter, J.] Tech Univ Munich, Hosp Rechts Isar, German Heart Ctr, D-80290 Munich, Germany. [Al-Mallah, M.] Wayne State Univ, Detroit, MI USA. [Berman, D.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Cademartiri, F.] Univ Parma, Campus Maggiore Hosp, I-43100 Parma, Italy. [Chang, H. J.] Yonsei Univ, Severance Hosp, Seoul 120749, South Korea. [Chow, B.] Univ Ottawa, Inst Heart, Ottawa, ON, Canada. [Kaufmann, P.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Min, J.] Weill Cornell Med Coll, New York, NY USA. [Villines, T.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0195-668X J9 EUR HEART J JI Eur. Heart J. PD AUG PY 2011 VL 32 SU 1 BP 982 EP 982 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA V28TI UT WOS:000208702707166 ER PT J AU An, J Tuan, CY Cheeseman, BA Gazonas, GA AF An, J. Tuan, C. Y. Cheeseman, B. A. Gazonas, G. A. TI Simulation of Soil Behavior under Blast Loading SO INTERNATIONAL JOURNAL OF GEOMECHANICS LA English DT Article DE Equation of state; Strain rate; Viscoplasticity; Soil modeling; Finite elements; Experiments; Blast loading AB A viscoplastic cap model was previously developed to address the high strain rate effect on soil behaviors. Although the model is an improvement over the inviscid cap model, it does not update soil density and bulk modulus as the shock wave propagates through the soil. Further, soil should be modeled as a three-phase porous media to accommodate various degrees of water saturation. This is especially true for the soil mass surrounding the source of energy release because each of the three phases responds differently to shock loading. A revised cap model comprising a Gruneisen equation of state for each of the three phases has been developed. These equations of state for solid, water, and air have been integrated with the viscoplastic cap model to simulate behaviors of soil with different degrees of water saturation. Numerical results from this revised soil cap model compared closely with experimental data from explosive tests in both dry and saturated soil. (C) 2011 American Society of Civil Engineers. C1 [An, J.; Tuan, C. Y.] Univ Nebraska Lincoln, Dept Civil Engn, Omaha, NE 68182 USA. [Cheeseman, B. A.; Gazonas, G. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Tuan, CY (reprint author), Univ Nebraska Lincoln, Dept Civil Engn, 203F PKI,1110 S 67th St, Omaha, NE 68182 USA. EM jan@unomaha.edu; ctuan@unomaha.edu; bcheesem@arl.army.mil; gazonas@arl.army.mil OI Gazonas, George/0000-0002-2715-016X NR 26 TC 11 Z9 12 U1 2 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1532-3641 J9 INT J GEOMECH JI Int. J. Geomech. PD AUG PY 2011 VL 11 IS 4 BP 323 EP 334 DI 10.1061/(ASCE)GM.1943-5622.0000086 PG 12 WC Engineering, Geological SC Engineering GA V28SC UT WOS:000208699500007 ER PT J AU Darwish, AM Hung, HA Viveiros, E Ibrahim, AA AF Darwish, Ali M. Hung, H. Alfred Viveiros, Edward Ibrahim, Amr A. TI Broadband AlGaN/GaN MMIC amplifier SO INTERNATIONAL JOURNAL OF MICROWAVE AND WIRELESS TECHNOLOGIES LA English DT Article DE Wide-Bandgap Semiconductors Devices and Technologies; Reliability and Statistical Analysis; Power Amplifiers and Linearizers AB A broadband Monolithic Microwave Integrated Circuit (MMIC) amplifier, with 12 +/- 2 dB gain across the 0.1-27 GHz band has been demonstrated using the AlGaN/GaN on SiC technology. The amplifier design employs a non-conventional, series-DC/RF-High Electron Mobility Transistor (HEMT) configuration. This configuration provides an alternative design to the conventional traveling-wave amplifier (TWA). It results in a smaller MMIC chip size, and extends amplifier gain to the low-frequency region. The amplifier MMIC utilizes four HEMT devices in series and could be biased at voltages up to 120 V. C1 [Darwish, Ali M.; Hung, H. Alfred; Viveiros, Edward] USA, Res Lab, Adelphi, MD 20783 USA. [Darwish, Ali M.; Ibrahim, Amr A.] Amer Univ Cairo, Cairo 11835, Egypt. RP Darwish, AM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu NR 20 TC 0 Z9 0 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1759-0787 J9 INT J MICROW WIREL T JI Int. J. Microw. Wirel. Technol. PD AUG PY 2011 VL 3 IS 4 BP 399 EP 404 DI 10.1017/S1759078711000195 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA V27KZ UT WOS:000208613400002 ER PT J AU Guelcher, SA Brown, KV Li, B Guda, T Lee, BH Wenke, JC AF Guelcher, Scott A. Brown, Kate V. Li, Bing Guda, Teja Lee, Baek-Hee Wenke, Joseph C. TI Dual-Purpose Bone Grafts Improve Healing and Reduce Infection SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE rhBMP-2; antibiotic; dual delivery; infection; contamination; PUR scaffold; critical size defect; controlled release ID SEGMENTAL DEFECT; POLYURETHANE SCAFFOLDS; ANTIBIOTIC BEADS; RAT FEMUR; IN-VITRO; VANCOMYCIN; FRACTURES; RELEASE; WOUNDS AB Objective: To determine if a dual-purpose bone graft can regenerate bone and reduce infection in highly contaminated bone critical size defects in rats. Methods: Biodegradable polyurethane (PUR) scaffolds were loaded with recombinant human bone morphogenetic protein-2 (BMP-2) and vancomycin (Vanc). The release kinetics of the BMP-2 were tuned to take advantage of its mechanism of action (ie, an initial burst to recruit cells and sustained release to induce differentiation of the migrating cells). The Vanc release kinetics were designed to protect the graft from contamination until it is vascularized by having a burst for a week and remaining well over the minimum inhibitory concentration for Staphylococcus aureus for 2 months. The bone regeneration and infection reduction capability of these dual-purpose grafts (PUR+Vanc+BMP-2) were compared with collagen sponges loaded with BMP-2 (collagen+BMP-2) and PUR+BMP-2 in infected critical size rat femoral segmental defects. Results: The dual-delivery approach resulted in substantially more new bone formation and a modest improvement in infection than PUR+BMP-2 and collagen+BMP-2 treatments. Conclusions: The PUR bone graft is injectable, provides a more sustained release of BMP-2 than the collagen sponge, and can release antibiotics for more than 8 weeks. Thus, the dual-delivery approach may improve patient outcomes of open fractures by protecting the osteoinductive graft from colonization until vascularization occurs. In addition, the more optimal release kinetics of BMP-2 may reduce nonunions and the amount of growth factor required. C1 [Brown, Kate V.; Guda, Teja; Wenke, Joseph C.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA. [Guelcher, Scott A.; Li, Bing; Lee, Baek-Hee] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN USA. [Guda, Teja] Wake Forest Univ, Wake Forest Inst Regenerat Med, Winston Salem, NC 27109 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil RI Guda, Teja/A-7286-2009 OI Guda, Teja/0000-0002-3218-2916 FU Orthopaedic Extremity Trauma Research Program [DOD-W81XWH-07-1-0211] FX Supported by the Orthopaedic Extremity Trauma Research Program (DOD-W81XWH-07-1-0211). NR 19 TC 35 Z9 35 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD AUG PY 2011 VL 25 IS 8 BP 477 EP 482 DI 10.1097/BOT.0b013e31821f624c PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 794BQ UT WOS:000292870300007 PM 21738070 ER PT J AU Lessig, MK Bauer, AJ AF Lessig, Megan K. Bauer, Andrew J. TI Thyroid Cancer: Caring for the Pediatric Patient SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES LA English DT News Item ID FOLLOW-UP; YOUNG-ADULTS; CHILDREN; MANAGEMENT; CARCINOMA; DIAGNOSIS; OUTCOMES; NODULES; DISEASE C1 [Lessig, Megan K.; Bauer, Andrew J.] Childrens Hosp Philadelphia, Div Endocrinol, Thyroid Ctr, Philadelphia, PA 19104 USA. [Bauer, Andrew J.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Bauer, Andrew J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Lessig, MK (reprint author), Childrens Hosp Philadelphia, Div Endocrinol, Thyroid Ctr, Philadelphia, PA 19104 USA. EM lessigm@email.chop.edu NR 25 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0882-5963 J9 J PEDIATR NURS JI J. Pediatr. Nurs. PD AUG PY 2011 VL 26 IS 4 BP 388 EP 391 DI 10.1016/j.pedn.2011.04.029 PG 4 WC Nursing; Pediatrics SC Nursing; Pediatrics GA 045OE UT WOS:000311705300019 ER PT J AU Wilson, DA AF Wilson, Derek A. TI Pipeline Dredge Analytical Program with Comparison to Field Data SO JOURNAL OF PIPELINE SYSTEMS ENGINEERING AND PRACTICE LA English DT Article DE Hydraulic pipeline dredging; Slurry transport; Dredge pump hydraulics; Coarse-grained sediment transport AB A clear understanding of pipeline dredge production capacity provides dredge operators and dredging project planners with the capability to accurately and effectively determine a project's cost and duration. Dredge pump and pipeline hydraulics coupled with slurry transport principles present a complex and challenging engineering system requiring specialized knowledge and understanding of how the system will operate. This study determines how well the theoretical principles of hydraulics and slurry transport govern the actual pipeline dredging process, compared with dredge pump and pipeline instrumentation data. Results indicate that the delivered pipeline slurry mixture incurred more friction losses during transport than water alone. This study further determines the maximum pumping capability of the dredge pump in terms of its maximum dredging depth and maximum pipeline length. These results determine that the pipeline dredge operated well within its operating limits during the case study. Overall, the comparison between pump and pipeline instrumentation data to the theoretical background formula demonstrates the reasonable effectiveness of applying the theoretical principles into an analytical program to measure and predict dredge performance. (C) 2011 American Society of Civil Engineers. C1 US Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Wilson, DA (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM derek.a.wilson@usace.army.mil FU U.S. ACE Dredging Operations and Environmental Research Program FX This paper summarizes the results of research conducted by the U. S. Army Engineer Research and Development Center, Waterways Experiment Station. Funding was provided by the U.S. ACE Dredging Operations and Environmental Research Program. Permission to publish this information was granted by the chief of engineers. NR 4 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1949-1190 EI 1949-1204 J9 J PIPELINE SYST ENG JI J. Pipel. Syst. Eng. Pract. PD AUG PY 2011 VL 2 IS 3 BP 107 EP 112 DI 10.1061/(ASCE)PS.1949-1204.0000078 PG 6 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA V31SX UT WOS:000208904400006 ER PT J AU Smith, TJ Anderson, D Margolis, LM Sikes, A Young, AJ AF Smith, Tracey J. Anderson, Danielle Margolis, Lee M. Sikes, Anthony Young, Andrew J. TI Persistence of Lactobacillus reuteri DSM17938 in the Human Intestinal Tract: Response to Consecutive and Alternate-Day Supplementation SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article DE probiotics; Lactobacillus reuteri; colonization AB Background: Probiotics may enhance gastrointestinal health and immune function. The efficacy of different probiotic dosing strategies on colonization and persistence of probiotics is undefined. Objective: The authors assessed colonization and persistence of Lactobacillus reuteri (L. reuteri) DSM17938 (BioGaia AB, Stockholm, Sweden) after daily or alternate-day dosing. Methods: Volunteers ate pudding with L. reuteri (10(9) CPU) daily (n=9) or on alternate days (n=9) over 7 days. Fecal samples were collected on dosing days (D1-7) and after dosing ended (D13-15 and D20-22) and were analyzed for the presence of L. reuteri. Results are reported in 3-day increments (D2-4, D5-7, D13-15, and D20-22). Results: L. reuteri count rose in response to daily supplementation ([mean +/- SD] D2-4: 4 X 10(4) +/- 2 X 10(4) CPU, p < 0.01; D5-7: 10 X 10(4) +/- 9 X 10(4) CPU, p < 0.01) and alternate-day supplementation (D2-4: 21 X 10(4) +/- 20 X 10(4) CPU, p < 0.01; D5-7: 11 X 10(4) +/- 15 X 10(4) CPU, p = 0.06) and fell in both groups 1 week after dosing ended (p < 0.01). Total volunteers with detectable L. reuteri 1 and 2 weeks after dosing ended was similar in response to daily feeding (4/9 and 2/9, respectively) and alternate-day feeding (3/9 and 2/9, respectively). L. reuteri count was higher D2-4 in response to alternate-day vs daily feeding (p < 0.05) but similar thereafter. Conclusions: Alternate-day probiotic intake achieves equivalent colonization to daily intake, but colonization declines rapidly once dosing stops. It is possible that, initially, responsiveness to probiotics may differ between individuals, but those differences do not persist with longer consumption. C1 [Smith, Tracey J.; Margolis, Lee M.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Anderson, Danielle; Sikes, Anthony] Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. RP Smith, TJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM tracey.j.smith@us.army.mil NR 19 TC 10 Z9 11 U1 0 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD AUG PY 2011 VL 30 IS 4 BP 259 EP 264 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA V28MR UT WOS:000208685400005 PM 21917706 ER PT J AU Hannah, ST Lord, RG Pearce, CL AF Hannah, Sean T. Lord, Robert G. Pearce, Craig L. TI Leadership and collective requisite complexity SO ORGANIZATIONAL PSYCHOLOGY REVIEW LA English DT Article DE emergent leadership; organizational change; social regulation; feedback; learning; shared leadership AB We maintain that the requisite complexity of collectives is an important component of collective learning and adaptive performance. Collective requisite complexity is comprised of two components: static complexity, which consists of group or team heterogeneity in general cognitive, social, self, and affective domains; and dynamic complexity, which is a social interactive process by which one person's contributions transform those of another. We propose that social-regulation processes involving active goals, identity, and affect, as well as formal and emergent leadership processes, such as shared leadership, provide the key social structures within which dynamic complexity emerges. We also propose that successful adaptation to task or organizational demands, as well as social feedback, transform these structural aspects through "double-loop learning'' and provide a basis for individual and collective learning. C1 [Hannah, Sean T.] US Mil Acad, West Point, West Point, NY USA. [Lord, Robert G.] Univ Akron, Psychol, Akron, OH 44325 USA. [Pearce, Craig L.] Amer Univ Nigeria, Sch Business & Entrepreneurship, Adamawa, Nigeria. RP Lord, RG (reprint author), Univ Akron, Dept Psychol, Akron, OH 44325 USA. EM rlord@uakron.edu NR 94 TC 14 Z9 15 U1 3 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 2041-3866 EI 2041-3874 J9 ORGAN PSYCHOL REV JI Organ. Psychol. Rev. PD AUG PY 2011 VL 1 IS 3 BP 215 EP 238 DI 10.1177/2041386611402116 PG 24 WC Psychology, Applied; Management SC Psychology; Business & Economics GA V38ZW UT WOS:000209382300002 ER PT J AU Suguna, M Kumar, NS Reddy, AS Boddu, VM Krishnaiah, A AF Suguna, M. Kumar, N. Siva Reddy, A. Subba Boddu, V. M. Krishnaiah, A. TI BIOSORPTION OF LEAD(II) FROM AQUEOUS SOLUTION ON GLUTARALDEHYDE CROSS-LINKED CHITOSAN BEADS SO CANADIAN JOURNAL OF CHEMICAL ENGINEERING LA English DT Article DE biosorption; Pb(II); glutaraldehyde cross-linked chitosan beads; isotherm models; kinetics; thermodynamics ID ACTIVATED CARBON; PB(II) IONS; ADSORPTION; REMOVAL; CADMIUM; EQUILIBRIUM; CU(II); PARAMETERS; KINETICS; SORPTION AB The ability of glutaraldehyde cross-linked chitosan beads (GCC beads) as synthetic adsorbent for adsorptive removal of Pb(II) ions from aqueous solutions is investigated in the present study. The biosorbent has been characterised by Brunner, Emmett, and Teller (BET) analysis, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) techniques. Equilibrium and column flow adsorption characteristics of Pb(II) ions on the biosorbent were studied. The effects of experimental variable parameters such as pH, concentration of metal ion, amount of adsorbent, contact time, temperature and interfering ions on adsorption have been investigated. The equilibrium data are fitted to pseudo-first order, pseudosecond order, fractionary order, chemisorption, Weber-Morris and Boyd models. Based on R(2) and error function values, it is observed that the kinetic data are better fitted to pseudo-second-order kinetic model and chemisorption model. The experimental data are analysed using Langmuir, Freundlich, and Sips adsorption isotherm models. The monolayer adsorption capacity of GCC beads as obtained from Langmuir isotherm at 35 degrees C is found to be 204.0 mg/g. The thermodynamic constants of the adsorption process: Delta H(0), Delta S(0) and Delta G(0) are evaluated. The results show that biosorption of Pb(II) ions on GCC beads are endothermic and spontaneous. C1 [Suguna, M.; Kumar, N. Siva; Reddy, A. Subba; Krishnaiah, A.] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. [Boddu, V. M.] USA, Engn Res & Dev Ctr, CERL, Champaign, IL 61822 USA. RP Krishnaiah, A (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr., Nadavala Siva Kumar /D-5404-2011 OI Dr., Nadavala Siva Kumar /0000-0003-3210-8254 NR 35 TC 8 Z9 8 U1 0 U2 20 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-4034 J9 CAN J CHEM ENG JI Can. J. Chem. Eng. PD AUG PY 2011 VL 89 IS 4 SI SI BP 833 EP 843 DI 10.1002/cjce.20462 PG 11 WC Engineering, Chemical SC Engineering GA 792IC UT WOS:000292735200019 ER PT J AU Letter, JV Mehta, AJ AF Letter, J. V., Jr. Mehta, A. J. TI A heuristic examination of cohesive sediment bed exchange in turbulent flows SO COASTAL ENGINEERING LA English DT Article DE Deposition; Erosion; Floc shear strength; Marine environment; Probabilistic variables; Suspended sediment concentration ID DEPOSITION; TRANSPORT; EROSION; GRAINS AB Prediction of the concentration of suspended cohesive sediment in the marine environment is constrained by difficulties in interpreting experimental evidence on bed exchange, i.e. erosion and deposition of particles, which remains sparse in mechanistic details. In this paper, conditions under which bed exchange in turbulent flows collectively determines the concentration of suspended matter have been examined in the heuristic sense based on selective experimental data. It is argued that interpretation of such data can be significantly facilitated when multi-class representation of particle size, collisional interaction between suspended particles and probabilistic representations of the bed shear stress along with variables describing particle behavior (critical shear stress for deposition, bed floc shear strength) are taken into account. Aggregation-floc growth and breakup kinetics-brings about shifts in the suspended particle size distribution; bed exchange is accordingly modulated and this in turn determines concentration dynamics. Probabilistic representation of the governing variables broadens the suspended sediment size spectrum by increasing the possibilities of inter-particle interactions relative to the mean-value representation. Simple models of bed exchange, which essentially rely on single-size assumption and mean-value representation of variables, overlook the mechanistic basis underpinning particle dynamics. (C) 2011 Elsevier B.V. All rights reserved. C1 [Mehta, A. J.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. [Letter, J. V., Jr.] USA, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Mehta, AJ (reprint author), Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. EM mehta@coastal.ufl.edu FU U.S. Army Engineer Research and Development Center (ERDC); Office of Naval Research [N00014-07-1-0448] FX The first author was financially supported during the study by the U.S. Army Engineer Research and Development Center (ERDC). The second author received funding from the Office of Naval Research project no. N00014-07-1-0448. NR 33 TC 6 Z9 6 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD AUG PY 2011 VL 58 IS 8 BP 779 EP 789 DI 10.1016/j.coastaleng.2011.04.003 PG 11 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 791IS UT WOS:000292659500011 ER PT J AU Convertino, M Donoghue, JF Chu-Agor, ML Kiker, GA Munoz-Carpena, R Fischer, RA Linkov, I AF Convertino, M. Donoghue, J. F. Chu-Agor, M. L. Kiker, G. A. Munoz-Carpena, R. Fischer, R. A. Linkov, I. TI Anthropogenic renourishment feedback on shorebirds: A multispecies Bayesian perspective SO ECOLOGICAL ENGINEERING LA English DT Article DE Habitat selection; Beach renourishment; Multi-species analysis; Snowy Plover; Piping Plover; Red Knot; Bayesian inference ID PLOVERS CHARADRIUS-ALEXANDRINUS; SNOWY PLOVERS; GEOGRAPHIC DISTRIBUTIONS; SPECIES DISTRIBUTIONS; HABITAT SELECTION; BEACH NOURISHMENT; NATAL DISPERSAL; NICHE; COMMUNITY; PHYLOGEOGRAPHY AB In this paper, the realized niche of the Snowy Plover (Charadrius alexandrinus). a primarily resident Florida shorebird, is described as a function of the scenopoetic and bionomic variables at the nest-, landscape-, and regional-scale. We identified some possible geomorphological controls that influence nest-site selection and survival using data collected along the Florida Gulf coast. In particular, we focused on the effects of beach replenishment interventions on the Snowy Plover (SP), and on the migratory Piping Plover (PP) (Charadrius melodus) and Red Knot (RK) (Calidris canutus). Additionally, we investigated the potential differences between the SP breeding and wintering distributions using only regional-scale physiognomic variables and the recorded occurrences. To quantify the relationship between past renourishment projects and shorebird species we used a Monte Carlo procedure to sample from the posterior distribution of the binomial probabilities that a region is not a nesting or a wintering ground conditional on the occurrence of a beach replenishment intervention in the same and the previous year. The results indicate that it was 2.3, 3.1, and 0.8 times more likely that a region was not a wintering ground following a year with a renourishment intervention for the SP, PP and RK respectively. For the SP it was 2.5. times more likely that a region was not a breeding ground after a renourishment event. Through a maximum entropy principle model we observed small differences in the habitat use of the SP during the breeding and the wintering season. However, the habitats where RK was observed appeared quite different. While ecological niche models at the macro-scale are useful for determining habitat suitability ranges, the characterization of the species' local niche is fundamentally important for adopting concrete multispecies management scenarios. Maintaining and creating optimal suitable habitats for SP characterized by sparse low vegetation in the foredunes areas, and uneven/low-slope beach surfaces, is the proposed conservation scenario to convert anthropic beach restorations and SP populations into a positive feedback without impacting other threatened shorebird species. (C) 2011 Elsevier B.V. All rights reserved. C1 [Convertino, M.; Chu-Agor, M. L.; Kiker, G. A.; Munoz-Carpena, R.] Univ Florida, Dept Agr & Biol Engn IFAS, Gainesville, FL 32611 USA. [Convertino, M.; Linkov, I.] USACE Engineer Res & Dev Ctr, Risk & Decis Sci Area, Concord, MA USA. [Donoghue, J. F.] Florida State Univ, Dept Earth Ocean & Atmospher Sci, Tallahassee, FL 32306 USA. [Fischer, R. A.] USACE Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Linkov, I.] Carnegie Mellon Univ, EPP Dept, Pittsburgh, PA 15213 USA. RP Convertino, M (reprint author), Univ Florida, Dept Agr & Biol Engn IFAS, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu RI Munoz-Carpena, Rafael/A-7588-2010; OI Munoz-Carpena, Rafael/0000-0003-2838-1514; Chu, Ma Librada/0000-0003-3732-7165 FU Strategic Environmental Research and Development Program (SERDP) [SI-1699, SI-1700] FX The authors acknowledge the funding from the Strategic Environmental Research and Development Program (SERDP) for projects SI-1699 and S1-1700. The authors also gratefully acknowledge the work of the Florida Fish and Wildlife Conservation Commission and the Florida Shorebird Alliance (employees, researchers, volunteers, and land owners) for collecting the SP data and making them available to the public. Chris Burney and Patricia Kelly (FWC) are acknowledged in particular. An anonymous reviewer is greatly acknowledged for his/her comments that significantly improved the manuscript. J.B. Elsner (Florida State University) is gratefully acknowledged for the insights regarding the model. Fig. S2(a) is from a field survey of R.A. Fisher, and Fig. S2(b and c) from a field survey of M. Convertino. The authors declare to have used the data only from the cited sources. The extensive assistance of the Eglin AFB personnel is particularly acknowledged. There are not conflicts of interests to declare. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 84 TC 11 Z9 12 U1 3 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD AUG PY 2011 VL 37 IS 8 BP 1184 EP 1194 DI 10.1016/j.ecoleng.2011.02.019 PG 11 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 788GW UT WOS:000292434400011 ER PT J AU Michel, R Cuellar, J AF Michel, Rene Cuellar, John TI RSO Interview with John Cuellar SO HEALTH PHYSICS LA English DT Editorial Material C1 [Michel, Rene] VA San Diego Hlth Care Syst VASDHS, San Diego, CA 92093 USA. [Cuellar, John] Army Environm Hyg Agcy, Aberdeen Proving Ground, MD USA. [Cuellar, John] Gorgas Army Community Hosp, Panama City, Panama. [Cuellar, John] Univ Texas Hlth Sci Ctr San Antonio, AMEDD Ctr & Sch, NBC Sci Branch, San Antonio, TX 78229 USA. [Cuellar, John] Univ Texas Hlth Sci Ctr San Antonio, Grad Sch, San Antonio, TX 78229 USA. [Cuellar, John] US Mil Acad, Dept Phys, West Point, NY 10996 USA. [Cuellar, John] DTRA, Ft Belvoir, VA USA. [Cuellar, John] Def Nucl Weap Sch, Albuquerque, NM USA. RP Michel, R (reprint author), VA San Diego Hlth Care Syst VASDHS, San Diego, CA 92093 USA. EM Rene.Michel@med.va.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD AUG PY 2011 VL 101 IS 2 SU S BP S101 EP S103 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 790WL UT WOS:000292621400001 ER PT J AU Anderson, KB Gibbons, RV Edelman, R Eckels, KH Putnak, RJ Innis, BL Sun, W AF Anderson, Kathryn B. Gibbons, Robert V. Edelman, Robert Eckels, Kenneth H. Putnak, Robert J. Innis, Bruce L. Sun, Wellington TI Interference and Facilitation Between Dengue Serotypes in a Tetravalent Live Dengue Virus Vaccine Candidate SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FLAVIVIRUS-NAIVE ADULTS; HEMORRHAGIC-FEVER; ANTIBODY-RESPONSES; HUMAN VOLUNTEERS; CLINICAL-TRIAL; IMMUNOGENICITY; FORMULATIONS; SAFETY; PATHOGENESIS; COUNTRIES AB Background. Live, multivalent vaccines have historically exhibited interference in humans; live dengue virus (DENV) vaccines have proven no exception. Methods. To characterize interactions between DENV serotypes in a tetravalent live-attenuated virus vaccine candidate, we analyzed data from a factorial clinical trial in which all combinations of high- and low-dose DENV serotypes were combined in 16 live-attenuated tetravalent vaccine formulations (N = 64) and administered to flavivirus-naive adult volunteers. Regression models considered the outcomes of reactogenicity and seroconversion, controlling for all serotype doses simultaneously. Additionally, results were compared against earlier evaluations of the same viruses administered as monovalent formulations. Results. DENV-1 was immunologically dominant in both monovalent and tetravalent formulations. In tetravalent formulations, DENV-1 and DENV-2 antagonized each other, with a high dose of one decreasing seroconversion to the other. However, high-dose DENV-1 significantly increased seroconversion against 3 or more serotypes, increasing seroconversion to DENV-1, DENV-3, and DENV-4. The highest reactogenicity occurred when DENV-1 was at high dose and all others were low; reactogenicity decreased with the incorporation of other high-dose serotypes. Conclusions. Interference and facilitation occurred between serotypes in the live vaccine candidate evaluated. These analyses suggest that it may be possible to exploit facilitation to increase overall seroconversion. C1 [Anderson, Kathryn B.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Edelman, Robert] Univ Maryland, Dept Med, Baltimore, MD 21201 USA. [Edelman, Robert] Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Eckels, Kenneth H.] Walter Reed Army Inst Res, Dept Biol Res, Silver Spring, MD USA. [Putnak, Robert J.; Innis, Bruce L.; Sun, Wellington] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Dept Virus Dis, Silver Spring, MD USA. RP Anderson, KB (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd, Atlanta, GA 30322 USA. EM kbander@learnlink.emory.edu FU United States Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, Maryland; Center for Vaccine Development, University of Maryland, Baltimore; Centers for Disease Control and Prevention [1R36CK00104] FX The clinical trials were funded by the United States Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, Maryland, under a task order contract with the Center for Vaccine Development, University of Maryland, Baltimore. The analysis was supported by Dissertation Grant 1R36CK00104 from the Centers for Disease Control and Prevention. The opinions expressed in this manuscript do not necessarily represent the official views of the United States Department of Defense or the United States Department of the Army. NR 34 TC 21 Z9 22 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2011 VL 204 IS 3 BP 442 EP 450 DI 10.1093/infdis/jir279 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 790BA UT WOS:000292562300019 PM 21742844 ER PT J AU Grujicic, M Arakere, G Pandurangan, B Hariharan, A Yen, CF Cheeseman, BA Fountzoulas, C AF Grujicic, M. Arakere, G. Pandurangan, B. Hariharan, A. Yen, C. -F. Cheeseman, B. A. Fountzoulas, C. TI Statistical Analysis of High-Cycle Fatigue Behavior of Friction Stir Welded AA5083-H321 SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE AA5083; fatigue behavior; friction stir welding; maximum likelihood estimation AB A review of the literature revealed that high-cycle fatigue data associated with friction stir-welded (FSW) joints of AA5083-H321 (a solid-solution-strengthened and strain-hardened/stabilized Al-Mg-Mn alloy) are characterized by a relatively large statistical scatter. This scatter is closely related to the intrinsic variability of the FSW process and to the stochastic nature of the workpiece material microstructure/properties as well as to the surface condition of the weld. Consequently, the use of statistical methods and tools in the analysis of FSW joints is highly critical. A three-step FSW-joint fatigue-strength/life statistical-analysis procedure is proposed in this study. Within the first step, the type of the most appropriate probability distribution function is identified. The parameters of the selected probability distribution function, along with their confidence limits, are computed in the second step. In the third step, a procedure is developed for assessment of the statistical significance of the effect of the FSW process parameters and fatigue specimen surface conditions. The procedure is then applied to a set of stress-amplitude versus number of cycles to failure experimental data in which the tool translational speed was varied over four levels, while the fatigue specimen surface condition was varied over two levels. The results obtained showed that a two-parameter weibull distribution function with its scale factor being dependent on the stress amplitude is the most appropriate choice for the probability distribution function. In addition, it is found that, while the tool translational speed has a first-order effect on the AA5083-H321 FSW-joint fatigue strength/life, the effect of the fatigue specimen surface condition is less pronounced. C1 [Grujicic, M.; Arakere, G.; Pandurangan, B.; Hariharan, A.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.; Fountzoulas, C.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; Army Research Office [W911NF-09-1-0513] FX The material presented in this article is based on study supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042, and by the Army Research Office-sponsored grant W911NF-09-1-0513. NR 12 TC 19 Z9 19 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD AUG PY 2011 VL 20 IS 6 BP 855 EP 864 DI 10.1007/s11665-010-9725-y PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 792MN UT WOS:000292749800003 ER PT J AU Song, JQ Wolf, SE Wu, XW Finnerty, CC Herndon, DN Jeschke, MG AF Song, Juquan Wolf, Steven E. Wu, Xiao-Wu Finnerty, Celeste C. Herndon, David N. Jeschke, Marc G. TI Proximal Gut Mucosal Epithelial Homeostasis in Aged IL-1 Type I Receptor Knockout Mice after Starvation SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE small intestinal epithelia; apoptosis; proliferation; TUNEL staining; PCNA staining ID PLACEBO-CONTROLLED TRIAL; PROGRAMMED CELL-DEATH; TUMOR-NECROSIS-FACTOR; NUTRITIONAL SUPPLEMENTATION; GROWTH-FACTOR; EXPRESSION; PROLIFERATION; INTERLEUKIN-1; ATROPHY; BURN AB Background. Previous studies have shown that starvation induces small bowel atrophy, and that atrophy diminishes with aging. In this experiment, we assessed whether starvation-induced atrophy of proximal gut mucosa is associated with the Interleukin-1 receptor (IL-1R) signaling pathway in aged mice. Materials and Methods. Thirty 26-month-old IL-1R knockout mice and age-matched wild-type C57BL/6 mice were randomly divided into two groups: ad libitum fed and fasted. Mice were euthanized 12 or 48 hours after starvation. The proximal small bowel was harvested for morphologic analysis. Gut epithelial cell proliferation was detected using immunohistochemical staining for proliferating cell nuclear antigen (PCNA), and apoptosis was identified using terminal deoxyuridine nick-end labeling (TUNEL) staining. Results. Aged IL-1R knockout mice were larger than aged-matched wild-type mice (P < 0.05). Proximal gut mucosal height and mucosal cell number were not different between aged IL-1R knockout and wild-type groups. The apoptosis index in gut epithelial cells was higher in fed IL-1R knockout versus wild-type mice (P < 0.05), while there was no significant difference in cell proliferation between both groups. Mucosal atrophy was induced in both aged IL-1R knockout and wild-type groups by starvation (P < 0.05), however, aged IL-1R knockout mice experienced greater loss in proximal gut weight, mucosal length, and corresponding cell number than did wild-type mice at the 12-h time point (P < 0.05). The apoptosis index in gut epithelial cells significantly increased in both groups after starvation (P < 0.05). Starvation decreased cell proliferation in IL-1R knockout mice (P < 0.05), but not in wild-type mice. Conclusions. The response in aged IL-1R knockout mice differs from wild-type mice in that starvation increases atrophy and is associated with decreased cell proliferation rather than increased apoptosis. (C) 2011 Elsevier Inc. All rights reserved. C1 [Song, Juquan; Finnerty, Celeste C.; Herndon, David N.; Jeschke, Marc G.] Univ Texas Med Branch, Dept Surg, Galveston, TX 77555 USA. [Song, Juquan; Finnerty, Celeste C.; Herndon, David N.; Jeschke, Marc G.] Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX 77555 USA. [Finnerty, Celeste C.] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA. [Jeschke, Marc G.] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA. [Wolf, Steven E.; Wu, Xiao-Wu] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Brooke Army Med Ctr, USA,Inst Surg Res, San Antonio, TX 78229 USA. RP Jeschke, MG (reprint author), Univ Texas Med Branch, Dept Surg, 301 Univ Blvd, Galveston, TX 77555 USA. EM majeschk@utmb.edu OI Wolf, Steven/0000-0003-2972-3440 FU Shriners Hospitals for Children [8460, 8640, 8660, 870, 8760]; National Institutes of Health [R01 GM056687, T32 GM008256, P50 GM060338] FX The authors acknowledge support for this work by grants from Shriners Hospitals for Children (8460, 8640, 8660, 870, and 8760) and National Institutes of Health (R01 GM056687, T32 GM008256, P50 GM060338). The authors have no competing interests to declare. NR 34 TC 4 Z9 4 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD AUG PY 2011 VL 169 IS 2 BP 209 EP 213 DI 10.1016/j.jss.2010.03.056 PG 5 WC Surgery SC Surgery GA 791BF UT WOS:000292634100016 PM 20605606 ER PT J AU Glasser, JS Markelz, AE Zera, WC Beckius, ML Mende, K Murray, CK AF Glasser, Jessie S. Markelz, Ana E. Zera, Wendy C. Beckius, Miriam L. Mende, Katrin Murray, Clinton K. TI Oral antibiotics for infections due to multidrug-resistant Gram-negative organisms SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE ESBL; Escherichia coli; Klebsiella pneumoniae; amoxicillin-clavulanic acid; cefdinir ID ESCHERICHIA-COLI; MILITARY; COMPLICATIONS; AFGHANISTAN; GENES; IRAQ AB We determined minimum inhibitory concentrations of rifampicin, nitrofurantoin, amoxicillin-clavulanic acid, and cefdinir, plus a combination of amoxicillin-clavulanic acid and cefdinir by broth microdilution for mainly wound isolates of Escherichia coli and Klebsiella pneumoniae. E. coli and K. pneumoniae susceptibilities increased by combining amoxicillin-clavulanic acid and cefdinir. C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Zera, Wendy C.; Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. [Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 14 TC 2 Z9 2 U1 1 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PD AUG PY 2011 VL 43 IS 8 BP 649 EP 651 DI 10.3109/00365548.2011.572908 PG 3 WC Infectious Diseases SC Infectious Diseases GA 792VF UT WOS:000292777800012 PM 21466257 ER PT J AU Midde, KK Batchinsky, AI Cancio, LC Shetty, S Komissarov, AA Florova, G Walker, KP Koenig, K Chroneos, ZC Allen, T Chung, K Dubick, M Idell, S AF Midde, Krishna K. Batchinsky, Andriy I. Cancio, Leopoldo C. Shetty, Sreerama Komissarov, Andrey A. Florova, Galina Walker, Kerfoot P., III Koenig, Kathy Chroneos, Zissis C. Allen, Tim Chung, Kevin Dubick, Michael Idell, Steven TI WOOD BARK SMOKE INDUCES LUNG AND PLEURAL PLASMINOGEN ACTIVATOR INHIBITOR 1 AND STABILIZES ITS mRNA IN PORCINE LUNG CELLS SO SHOCK LA English DT Article DE Acute lung injury; fibrin; fibrinolysis; serpin; smoke inhalation ID RESPIRATORY-DISTRESS-SYNDROME; FIBRIN DEPOSITION; INJURY; INHALATION; PAI-1; UROKINASE; SHEEP; COAGULATION; EXPRESSION; RABBITS AB Although aberrant fibrinolysis and plasminogen activator inhibitor 1 (PAI-1) are implicated in acute lung injury, the role of this serpin in the pathogenesis of wood bark smoke (WBS)-induced acute lung injury (SIALI) and its regulation in resident lung cells after exposure to smoke are unclear. A total of 22 mechanically ventilated pigs were included in this study. Immunohistochemical analyses were used to assess fibrin and PAI-1 in the lungs of pigs with SIALI in situ. Plasminogen activator inhibitor 1 was measured in bronchoalveolar lavage fluids by Western blotting. Induction of PAI-1 was determined at the protein and mRNA levels by Western and polymerase chain reaction analyses in primary porcine alveolar type II cells, fibroblasts, and pleural mesothelial cells. Plasminogen activator inhibitor 1 mRNA stability was determined by transcription chase studies. Gel shift analyses were used to characterize the mechanism regulating PAI-1 mRNA stability. Smoke-induced ALI induced PAI-1, with prominent extravascular fibrin deposition in large and small airways as well as alveolar and subpleural compartments. In pleural mesothelial cells, lung fibroblasts, and alveolar type II cells, PAI-1 mRNA was stabilized by WBS extract and contributed to induction of PAI-1. The mechanism involves dissociation of a novel 6-phospho-D-gluconate-NADP oxidoreductase-like PAI-1 mRNA binding protein from PAI-1 mRNA. Exposure to WBS induces prominent airway and mesothelial expression of PAI-1, associated with florid distribution of fibrin in SIALI in vivo Wood bark smoke components induce PAI-1 in vitro in part by stabilization of PAI-1 mRNA, a newly recognized pathway that may promote extravascular fibrin deposition and lung dysfunction in SIALI. C1 [Idell, Steven] Univ Texas Hlth Sci Ctr Tyler, Lab C 6, Texas Lung Injury Inst, Tyler, TX 75708 USA. [Batchinsky, Andriy I.; Cancio, Leopoldo C.; Walker, Kerfoot P., III; Chung, Kevin; Dubick, Michael] USA, Inst Surg Res, Houston, TX USA. [Chroneos, Zissis C.] Univ Texas Hlth Sci Ctr Tyler, Dept Biochem, Tyler, TX 75708 USA. [Allen, Tim] Univ Texas Hlth Sci Ctr Tyler, Dept Pathol, Tyler, TX 75708 USA. RP Idell, S (reprint author), Univ Texas Hlth Sci Ctr Tyler, Lab C 6, Texas Lung Injury Inst, Routes 271 & 155, Tyler, TX 75708 USA. EM steven.idell@uthct.edu RI Midde, Krishna/F-6916-2013 FU National Institutes of Health (NHLBI PPG) [PO1 HL076406, R-21-HL093547, FAMRI-ID-082380]; Texas Lung Injury Institute; US Army Medical Research and Materiel Command FX This study was supported by the National Institutes of Health (NHLBI PPG PO1 HL076406, R-21-HL093547, FAMRI-ID-082380), the Texas Lung Injury Institute, and the Combat Critical Care Engineering task area, Combat Casualty Care Research Program, US Army Medical Research and Materiel Command. NR 24 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD AUG PY 2011 VL 36 IS 2 BP 128 EP 137 DI 10.1097/SHK.0b013e31821d60a4 PG 10 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 792TJ UT WOS:000292772600006 PM 21478814 ER PT J AU Levi, M Fries, D Gombotz, H van der Linden, P Nascimento, B Callum, JL Belisle, S Rizoli, S Hardy, JF Johansson, PI Samama, CM Grottke, O Rossaint, R Henny, CP Goslings, JC Theusinger, OM Spahn, DR Ganter, MT Hess, JR Dutton, RP Scalea, TM Levy, JH Spinella, PC Panzer, S Reesink, HW AF Levi, M. Fries, D. Gombotz, H. van der Linden, Ph Nascimento, B. Callum, J. L. Belisle, S. Rizoli, S. Hardy, J. -F. Johansson, P. I. Samama, C. M. Grottke, O. Rossaint, R. Henny, C. P. Goslings, J. C. Theusinger, O. M. Spahn, D. R. Ganter, M. T. Hess, J. R. Dutton, R. P. Scalea, T. M. Levy, J. H. Spinella, P. C. Panzer, S. Reesink, H. W. TI Prevention and treatment of coagulopathy in patients receiving massive transfusions SO VOX SANGUINIS LA English DT Article ID FRESH-FROZEN PLASMA; DIRECTED COAGULATION MANAGEMENT; ACUTE LUNG INJURY; TRAUMA PATIENTS; MAJOR TRAUMA; PLATELET TRANSFUSIONS; CONTROL RESUSCITATION; FLUID RESUSCITATION; CLINICAL MANAGEMENT; EUROPEAN GUIDELINE C1 [Levy, J. H.] Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA. [Levy, J. H.] Emory Healthcare, Atlanta, GA USA. [Levi, M.] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1105 AZ Amsterdam, Netherlands. [Reesink, H. W.] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands. [Panzer, S.] Univ Vienna, Univ Klin Blut Grp Serol & Transfus Med, Klin Abt Blut Grp Serol, Vienna, Austria. [Fries, D.] Med Univ Innsbruck, Dept Gen & Surg Crit Care Med, Innsbruck, Austria. [Gombotz, H.] Gen Hosp Linz, Dept Anesthesiol & Intens Care, Linz, Austria. [van der Linden, Ph] CHU Brugmann HUDERF, Dept Anesthesiol, Brussels, Belgium. [Hardy, J. -F.] CHUM Hop Notre Dame, Dept Anesthesiol, Montreal, PQ H2L 4M1, Canada. [Hardy, J. -F.] Univ Montreal, Montreal, PQ H3C 3J7, Canada. [Samama, C. M.] Hotel Dieu Univ Hosp, Dept Anaesthesiol & Intens Care Med, F-75181 Paris 04, France. [Grottke, O.; Rossaint, R.] RWTH Aachen Univ Hosp, Dept Anesthesiol, D-52074 Aachen, Germany. [Henny, C. P.; Goslings, J. C.] Univ Amsterdam, Acad Med Ctr, Dept Surg, Trauma Unit, NL-1105 AZ Amsterdam, Netherlands. [Theusinger, O. M.] Univ Zurich Hosp, Inst Anesthesiol, CH-8091 Zurich, Switzerland. [Hess, J. R.] Univ Maryland, Sch Med, Blood Bank, UMMC, Baltimore, MD 21201 USA. [Dutton, R. P.; Scalea, T. M.] Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Dutton, R. P.] Amer Soc Anesthesiol, Anesthesia Qual Inst, Chicago, IL USA. [Spinella, P. C.] Blood Syst Res Inst, San Francisco, CA USA. [Spinella, P. C.] USA, Blood Res Program, Inst Surg Res, San Antonio, TX USA. RP Levy, JH (reprint author), Emory Univ Hosp, 1364 Clifton Rd, Atlanta, GA 30322 USA. EM m.m.levi@amc.nl; dietmar.fries@i-med.ac.at; hans.gombotz@akh.linz.at; philippe.vanderlinden@chu-brugmann.be; jean-Francois.hardy@umontreal.ca; marc.samama@htd.aphp.fr; ogrottke@ukaachen.de; rrossaint@ukaachen.de; c.p.henny@amc.nl; j.c.goslings@amc.nl; oliver.theusinger@usz.ch; jhess@umm.edu; jlevy01@emory.edu; Phil_spinella@yahoo.com; internationalforum@kpnplanet.nl; internationalforum@kpnplanet.nl RI Hess, John/K-4001-2013; Johansson, Par/P-9283-2015; OI Hess, John/0000-0001-8596-4420; Johansson, Par/0000-0001-9778-5964; Hardy, Jean-Francois/0000-0002-8254-3011 NR 64 TC 37 Z9 39 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD AUG PY 2011 VL 101 IS 2 BP 154 EP 174 DI 10.1111/j.1423-0410.2011.01472.x PG 21 WC Hematology SC Hematology GA 791FL UT WOS:000292650000008 PM 21749403 ER PT J AU Shintri, S Rao, S Sarney, W Garg, S Palosz, W Trivedi, S Wijewarnasuriya, P Bhat, I AF Shintri, Shashidhar Rao, Sunil Sarney, Wendy Garg, Saurabh Palosz, Witold Trivedi, Sudhir Wijewarnasuriya, Priyalal Bhat, Ishwara TI Effect of As Passivation on Vapor-Phase Epitaxial Growth of Ge on (211)Si as a Buffer Layer for CdTe Epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE Germanium; epitaxy; chemical vapor deposition (CVD); arsenic passivation; (211)Si ID MOLECULAR-BEAM EPITAXY; SI(111); SURFACE; HETEROEPITAXY; KINETICS; SI(100); SI(001) AB We report an investigation of epitaxial germanium grown by chemical vapor deposition (CVD) on arsenic-terminated (211)Si, which is the preferred substrate in the USA for fabrication of night-vision devices based on mercury cadmium telluride (MCT) grown by molecular-beam epitaxy (MBE). The films were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), cross-sectional transmission electron microscopy (XTEM), and x-ray diffraction (XRD). Arsenic passivation was found to be effective in preventing cross-contamination of unwanted residual species present inside the reactor chamber and also in prolonging the evolution of layer-by-layer growth of Ge for significantly more monolayers than on nonpassivated Si. The two-dimensional (2D) to three-dimensional (3D) transition resulted in Ge islands, the density and morphology of which showed a clear distinction between passivated and nonpassivated (211)Si. Finally, thick Ge layers (similar to 250 nm) were grown at 525A degrees C and 675A degrees C with and without As passivation, where the layers grown with As passivation resulted in higher crystal quality and smooth surface morphology. C1 [Shintri, Shashidhar] Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. [Rao, Sunil; Bhat, Ishwara] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Sarney, Wendy; Wijewarnasuriya, Priyalal] USA, Res Lab, Adelphi, MD 20783 USA. [Garg, Saurabh] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Palosz, Witold; Trivedi, Sudhir] Brimrose Corp Amer, Sparks, MD 21152 USA. RP Shintri, S (reprint author), Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. EM shints@rpi.edu FU US Army STTR through Brimrose Corporation [W911NF-08-C-0071] FX This work was partially supported by US Army STTR contract W911NF-08-C-0071 through Brimrose Corporation. We thank Dr. William Clark of ARO for all the encouragement. NR 17 TC 2 Z9 2 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1637 EP 1641 DI 10.1007/s11664-011-1627-8 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000005 ER PT J AU D'Souza, AI Robinson, E Wijewarnasuriya, PS Stapelbroek, MG AF D'Souza, A. I. Robinson, E. Wijewarnasuriya, P. S. Stapelbroek, M. G. TI Spectral Response Model of Backside-Illuminated HgCdTe Detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE Spectral response; backside illumination; detector; II-VI semiconductor ID PHOTOVOLTAIC DETECTORS AB Backside-illuminated HgCdTe detectors fabricated on thick CdZnTe substrates have an optical path such that the incident radiation traverses the antireflection (AR) coating layers, the thick CdZnTe substrate, and finally the different layers of the detector. Modeling the spectral response first involves a coherent calculation of the transmission and reflection of a multilayer AR coating on the backside of the CdZnTe substrate. Second, a coherent calculation is made of the reflection and transmission coefficients for the stack of detector materials including wavelength-dependent complex refractive indexes for the detector materials. Third, the transmission and reflection coefficients are then used in an incoherent calculation to account for the multiple reflections in the thick CdZnTe substrate. For the coherent calculations, a stack matrix is constructed from the multiplication of matrices that track the phase and amplitude of the waves propagating across interfaces and from one side of a layer to the other side. These calculations are combined to compute the spectral response and reflectance of the detector as a function of wavelength. C1 [D'Souza, A. I.; Robinson, E.] DRS Def Solut, Cypress, CA 90630 USA. [Wijewarnasuriya, P. S.] USA, Res Lab, Adelphi, MD 20783 USA. [Stapelbroek, M. G.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. RP D'Souza, AI (reprint author), DRS Def Solut, 10600 Valley View St, Cypress, CA 90630 USA. EM arvind.d'souza@drs-sts.com NR 13 TC 3 Z9 3 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1657 EP 1662 DI 10.1007/s11664-011-1637-6 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000009 ER PT J AU Brill, G Chen, Y Wijewarnasuriya, P AF Brill, G. Chen, Y. Wijewarnasuriya, P. TI Study of HgCdSe Material Grown by Molecular Beam Epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdSe; MBE; GaSb; nucleation; voids; ZnTe/Si; IR; II-VI ID HGSE AB Much progress has been made in developing high-quality HgCdTe/Si for large-area focal-plane array (FPA) applications. However, even with all the material advances made to date, there is no guarantee that this technology will be mature enough to meet the stringent FPA specifications required for long-wavelength infrared (LWIR) systems. With this in mind, the Army Research Laboratory (ARL) has begun investigating HgCdSe material for infrared (IR) applications. Analogous to HgCdTe, HgCdSe is a tunable semiconductor that can detect any wavelength of IR radiation through control of the alloy composition. In addition, several mature, large-area bulk III-V substrates are nearly lattice matched to HgCdSe, giving this system a possible advantage over HgCdTe, for which no scalable, bulk substrate technology exists. We have initiated a study of the growth of HgCdSe using molecular beam epitaxy (MBE). Growth temperature and material flux ratios were varied to ascertain the best growth conditions. Smooth surface morphology has been achieved using a growth temperature much lower than that used for HgCdTe. Additionally, zero void defects were nucleated at these lower temperatures. Preliminary data suggest a linear relationship between the Se/Cd flux ratio used during growth and the cutoff wavelength as measured by Fourier-transform infrared (FTIR) spectroscopy. C1 [Brill, G.; Chen, Y.; Wijewarnasuriya, P.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Brill, G (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gbrill@arl.army.mil RI Brill, Gregory/G-4877-2013 NR 15 TC 11 Z9 12 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1679 EP 1684 DI 10.1007/s11664-011-1643-8 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000013 ER PT J AU Billman, CA Almeida, LA Smith, P Arias, JM Chen, A Lee, D Piquette, EC AF Billman, C. A. Almeida, L. A. Smith, P. Arias, J. M. Chen, A. Lee, D. Piquette, E. C. TI The Effects of Microvoid Defects on MWIR HgCdTe-Based Diodes SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdTe; defects; microvoid; infrared detector; dark current ID MOLECULAR-BEAM EPITAXY; GROWTH; PERFORMANCE; IMPACT; HGTE AB The effects of microvoid defects on the performance of mid-wavelength infrared (MWIR) HgCdTe-based diodes were examined. Molecular beam epitaxy (MBE) was utilized to deposit indium-doped, Hg0.68Cd0.32Te on 2 cm x 3 cm, (211)B-oriented, bulk Cd0.96Zn0.04Te substrates. These epilayers generally exhibited state-of-the-art material properties with a notable exception: high and nonuniform microvoid defect densities (mid 10(4) cm(-2) to low 10(6) cm(-2)). Diodes were fabricated by ion implantation of arsenic to form planar p-n junctions. Dark current-voltage (I-V) curves were measured and analyzed as a function of operating temperature. There was an inverse correlation between wafer-level microvoid defect density and device operability. On each wafer, devices with the smallest implants exhibited higher operability than devices with larger implants. By removal of pad metal and examination of defects within each implant area, it was found that the presence of one or more microvoids within the junction usually caused tunneling or other high-current mechanisms. Diodes free from microvoids exhibited diffusion-limited behavior down to 150 K, the test set limit. C1 [Billman, C. A.; Almeida, L. A.; Smith, P.; Arias, J. M.] USA, RDECOM CERDEC, NVESD, Ft Belvoir, VA USA. [Chen, A.; Lee, D.; Piquette, E. C.] Teledyne Imaging Sensors, Camarillo, CA USA. RP Billman, CA (reprint author), USA, RDECOM CERDEC, NVESD, Ft Belvoir, VA USA. EM info@nvl.army.mil NR 8 TC 3 Z9 3 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1693 EP 1698 DI 10.1007/s11664-011-1658-1 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000016 ER PT J AU Al-Amoody, F Suarez, E Rodriguez, A Heller, E Huang, WL Jain, F AF Al-Amoody, Fuad Suarez, Ernesto Rodriguez, Angel Heller, E. Huang, Wenli Jain, F. TI Core-Shell Zn (x) Cd1-x Se/Zn (y) Cd1-y Se Quantum Dots for Nonvolatile Memory and Electroluminescent Device Applications SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE Floating quantum dot gate; nonvolatile memory; electroluminescent device; ZnCdSe quantum dots; photo-assisted microwave plasma MOCVD ID NANOCRYSTALS AB This paper presents a floating quantum dot (QD) gate nonvolatile memory device using high-energy-gap Zn (y) Cd1-y Se-cladded Zn (x) Cd1-x Se quantum dots (y > x) with tunneling layers comprising nearly lattice-matched semiconductors (e.g., ZnS/ZnMgS) on Si channels. Also presented is the fabrication of an electroluminescent (EL) device with embedded cladded ZnCdSe quantum dots. These ZnCdSe quantum dots were embedded between indium tin oxide (ITO) on glass and a top Schottky metal electrode deposited on a thin CsF barrier. These QDs, which were nucleated in a photo-assisted microwave plasma (PMP) metalorganic chemical vapor deposition (MOCVD) reactor, were grown between the source and drain regions on a p-type silicon substrate of the nonvolatile memory device. The composition of QD cladding, which relates to the value of y in Zn (y) Cd1-y Se, was engineered by the intensity of ultraviolet light, which controlled the incorporation of zinc in ZnCdSe. The QD quality is comparable to those deposited by other methods. Characteristics and modeling of the II-VI quantum dots as well as two diverse types of devices are presented in this paper. C1 [Al-Amoody, Fuad; Suarez, Ernesto; Jain, F.] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. [Rodriguez, Angel] Intel Corp, Rio Rancho, NM USA. [Heller, E.] RSoft Design Grp, Ossining, NY USA. [Huang, Wenli] US Mil Acad, West Point, NY 10996 USA. RP Al-Amoody, F (reprint author), Univ Connecticut, Dept Elect & Comp Engn, 371 Fairfield Rd, Storrs, CT 06269 USA. EM fcj@engr.uconn.edu FU ONR [N00014-06-1-0016, N00014-08-1-0149]; NSF [0622068] FX The authors gratefully acknowledge discussions with Dr. Daniel Purdy, and support of ONR Grants (N00014-06-1-0016 and N00014-08-1-0149) and NSF Grant ECS#0622068. Silicon nitride layers were grown by C. Tillinghast at Yale University. NR 19 TC 0 Z9 0 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1699 EP 1705 DI 10.1007/s11664-011-1663-4 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000017 ER PT J AU Farrell, S Rao, MV Brill, G Chen, Y Wijewarnasuriya, P Dhar, N Benson, D Harris, K AF Farrell, S. Rao, Mulpuri V. Brill, G. Chen, Y. Wijewarnasuriya, P. Dhar, N. Benson, D. Harris, K. TI Effect of Cycle Annealing Parameters on Dislocation Density Reduction for HgCdTe on Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdTe; thermal cycle annealing; dislocation; etch pit density; mercury; cadmium telluride; Si; composite substrates ID MOLECULAR-BEAM EPITAXY; GAAS; PHOTODIODES AB In our previous study of ex situ thermal cycle annealing (TCA) of molecular beam epitaxy (MBE)-grown mercury cadmium telluride (HgCdTe) on CdTe/Si(211) composite substrates we showed consistent dislocation density reduction to similar to 1 x 10(6) cm(-2). In this work, we have extended our study to understand the effects of TCA at lower temperatures and fewer cycles than studied previously. By examining TCA performed at the lower end of the temperature spectrum (as low as 385A degrees C), we are able to show an exponential correlation between etch pit density (EPD) and temperature. Varying the number of cycles also shows a similar exponential correlation with EPD. These results suggest that these are the two major factors driving dislocation annihilation and/or coalescence. In this paper, we discuss the theoretical mechanism behind dislocation reduction, both at the surface and throughout the bulk of the HgCdTe layer. C1 [Farrell, S.; Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Brill, G.; Chen, Y.; Wijewarnasuriya, P.; Dhar, N.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Benson, D.] USA, RDECOM CERDEC Night Vis & Elect Sensors Direct, Ft Belvoir, VA USA. [Harris, K.] Penn State Electroopt Ctr, Freeport, PA 16229 USA. RP Farrell, S (reprint author), George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. EM farrell_stu@yahoo.com RI Brill, Gregory/G-4877-2013 FU U.S. Army Research Office (ARO) [W911NF-07-2-0055]; Penn State Electro-Optics Center FX The work at George Mason University (GMU) is supported by the U.S. Army Research Office (ARO) under Grant No. W911NF-07-2-0055 and also by the Penn State Electro-Optics Center. NR 16 TC 11 Z9 11 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1727 EP 1732 DI 10.1007/s11664-011-1669-y PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000020 ER PT J AU Zhao, F Jacobs, RN Jaime-Vasquez, M Bubulac, LO Smith, DJ AF Zhao, F. Jacobs, R. N. Jaime-Vasquez, M. Bubulac, L. O. Smith, David J. TI Microstructural Characterization of CdTe(211)B/ZnTe/Si(211) Heterostructures Grown by Molecular Beam Epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE CdTe; ZnTe; transmission electron microscopy (TEM); high-angle annular-dark-field (HAADF) imaging ID CDTE/SI HETEROSTRUCTURES; MISORIENTED SI(001); SI(112) SURFACE; 112 SI; HETEROEPITAXY; SUBSTRATE; REDUCTION; EPILAYERS; DENSITY; HGCDTE AB Transmission electron microscopy and small-probe microanalysis have been used to investigate the microstructure and compositional profiles of CdTe(211)B/ZnTe/Si(211) heterostructures. Thin ZnTe buffer layers and subsequent thick CdTe layers were grown on Si(211) substrates using molecular beam epitaxy. Many {111}-type stacking faults were found to be present throughout the entire ZnTe layer, terminating near the point of initiation of CdTe growth. A rotation angle of about 3.5A degrees was observed between lattice planes of the Si substrate and the final CdTe epilayer. Local lattice parameter measurement and elemental profiles indicated that some intermixing of Zn and Cd had taken place. The average widths of the ZnTe layer and the (Cd,Zn)Te transition region were found to be roughly 6.5 nm and 3.5 nm, respectively. C1 [Zhao, F.] Arizona State Univ, Sch Mat, Tempe, AZ 85287 USA. [Jacobs, R. N.; Jaime-Vasquez, M.; Bubulac, L. O.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. [Smith, David J.] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. RP Zhao, F (reprint author), Arizona State Univ, Sch Mat, Tempe, AZ 85287 USA. EM wenfeng.zhao@asu.edu FU ARO [54657EL] FX The work at Arizona State University has been supported by ARO Contract #54657EL (Monitor: Dr. W. Clark). We also acknowledge the use of facilities in the John M. Cowley Center for High Resolution Electron Microscopy. NR 21 TC 5 Z9 5 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1733 EP 1737 DI 10.1007/s11664-011-1673-2 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000021 ER PT J AU Stoltz, AJ Benson, JD Carmody, M Farrell, S Wijewarnasuriya, PS Brill, G Jacobs, R Chen, Y AF Stoltz, A. J. Benson, J. D. Carmody, M. Farrell, S. Wijewarnasuriya, P. S. Brill, G. Jacobs, R. Chen, Y. TI Reduction of Dislocation Density in HgCdTe on Si by Producing Highly Reticulated Structures SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdTe; ICP; ECR; plasma processing; threading dislocation; gettering; reticulation ID MOLECULAR-BEAM EPITAXY AB HgCdTe, because of its narrow band gap and low dark current, is the infrared detector material of choice for several military and commercial applications. CdZnTe is the substrate of choice for HgCdTe as it can be lattice matched, resulting in low-defect-density epitaxy. Being often small and not circular, layers grown on CdZnTe are difficult to process in standard semiconductor equipment. Furthermore, CdZnTe can often be very expensive. Alternative inexpensive large circular substrates, such as silicon or gallium arsenide, are needed to scale production of HgCdTe detectors. Growth of HgCdTe on these alternative substrates has its own difficulty, namely a large lattice mismatch (19% for Si and 14% for GaAs). This large mismatch results in high defect density and reduced detector performance. In this paper we discuss ways to reduce the effects of dislocations by gettering these defects to the edge of a reticulated structure. These reticulated surfaces enable stress-free regions for dislocations to glide to. In the work described herein, HgCdTe-on-Si diodes have been produced with R (0) A (0) of over 400 Omega cm(2) at 78 K and cutoff of 10.1 mu m. Further, these diodes have good uniformity at 78 K at both 9.3 mu m and 10.14 mu m. C1 [Stoltz, A. J.; Benson, J. D.; Jacobs, R.] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Carmody, M.] Teledyne Imaging Sensors, Camarillo, CA 93012 USA. [Farrell, S.; Wijewarnasuriya, P. S.; Chen, Y.] USA, Res Lab, Adelphi, MD 20783 USA. RP Stoltz, AJ (reprint author), USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. EM andrew.stoltz@us.army.mil RI Brill, Gregory/G-4877-2013 NR 9 TC 10 Z9 10 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1785 EP 1789 DI 10.1007/s11664-011-1697-7 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000029 ER PT J AU Rao, SR Shintri, SS Markunas, JK Jacobs, RN Bhat, IB AF Rao, S. R. Shintri, S. S. Markunas, J. K. Jacobs, R. N. Bhat, I. B. TI High-Quality (211)B CdTe on (211)Si Substrates Using Metalorganic Vapor-Phase Epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE MOVPE; MOCVD; (211) orientation; CdTe; silicon; germanium; ZnTe; arsenic; cyclic anneal ID MOLECULAR-BEAM EPITAXY; DIRECT GROWTH; 211 SI; HETEROEPITAXY; PERFORMANCE AB High-quality (211)B CdTe buffer layers are required during Hg1-x Cd (x) Te heteroepitaxy on Si substrates. In this study, direct metalorganic vapor-phase epitaxy (MOVPE) of (211)B CdTe on Si, as well as CdTe on Si using intermediate Ge and ZnTe layers, has been achieved. Tertiary butyl arsine was used as a precursor to enable As surfactant action during CdTe MOVPE on Si. The grown CdTe/Si films display a best x-ray diffraction rocking-curve full-width at half-maximum of 64 arc-s and a best Everson etch pit density of 3 x 10(5) cm(-2). These values are the best reported for MOVPE-grown (211)B CdTe/Si and match state-of-the-art material grown using molecular-beam epitaxy. C1 [Rao, S. R.; Bhat, I. B.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Shintri, S. S.] Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. [Markunas, J. K.; Jacobs, R. N.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Rao, SR (reprint author), Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, 110 8th St, Troy, NY 12180 USA. EM raos@rpi.edu FU US Army STTR through Agiltron Inc. [W911NF-07-C-0105]; US Army STTR through Brimrose Corporation [W911NF-08-C-0071] FX This work was partially supported by US Army STTR contracts W911NF-07-C-0105 through Agiltron Inc. (Dr. Matthew Erdtmann) and W911NF-08-C-0071 through Brimrose Corporation. Many discussions with Dr. P. Wijewarnasuriya of ARL are also appreciated. We thank Dr. William Clark of ARO for all his encouragement. NR 14 TC 4 Z9 4 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1790 EP 1794 DI 10.1007/s11664-011-1586-0 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000030 ER PT J AU Markunas, JK Jacobs, RN Smith, PJ Pellegrino, J AF Markunas, J. K. Jacobs, R. N. Smith, P. J. Pellegrino, J. TI Si Wafer Thinning Techniques Compatible With Epitaxy of CdTe Buffer Layers SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdTe; CdTe; Silicon; compliant substrate; wafer thinning; threading dislocation; mismatched heteroepitaxy ID MOLECULAR-BEAM EPITAXY; HGCDTE; GROWTH; HETEROEPITAXY; DETECTORS AB Reduction of threading dislocation density is critical for improving the performance of HgCdTe detectors on lattice-mismatched alternative substrates such as Si. CdTe buffer layers grown by molecular beam epitaxy (MBE), with thicknesses on the order of 8 mu m to 12 mu m, have helped reduce dislocation densities in HgCdTe layers. In this study, the reduction of threading dislocation densities in CdTe buffer layers grown on locally thinned Si substrates was examined. A novel Si back-thinning technique was developed that maintained an epiready front surface and achieved Si thicknesses as low as 1.9 mu m. Threading dislocation densities, acquired by defect decoration techniques, were reduced by as much as 60% for CdTe buffer layers grown on these thinned regions when compared with unthinned regions. However, this reduction is inconsistent with prior notions that threading dislocation propagation is dominated by image forces. Instead, the thickness gradient of thinned Si may play a larger role. C1 [Markunas, J. K.; Jacobs, R. N.; Smith, P. J.; Pellegrino, J.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Markunas, JK (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM justin.markunas@nvl.army.mil NR 22 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1809 EP 1814 DI 10.1007/s11664-011-1651-8 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000033 ER PT J AU Benson, JD Farrell, S Brill, G Chen, Y Wijewarnasuriya, PS Bubulac, LO Smith, PJ Jacobs, RN Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, A Lee, U Vilela, MF Peterson, J Johnson, SM Lofgreen, DD Rhiger, D Patten, EA Goetz, PM AF Benson, J. D. Farrell, S. Brill, G. Chen, Y. Wijewarnasuriya, P. S. Bubulac, L. O. Smith, P. J. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. Lee, U. Vilela, M. F. Peterson, J. Johnson, S. M. Lofgreen, D. D. Rhiger, D. Patten, E. A. Goetz, P. M. TI Dislocation Analysis in (112)B HgCdTe/CdTe/Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials (II-VI workshop) CY OCT 26-28, 2010 CL New Orleans, LA DE HgCdTe/CdTe/Si; molecular beam epitaxy; dislocation; cyclic annealing; etch pit density ID MOLECULAR-BEAM EPITAXY; DIODE PERFORMANCE; HGCDTE; REDUCTION; SI; GROWTH; GAAS AB High-quality (112)B HgCdTe/Si epitaxial films with a dislocation density of similar to 9 x 10(5) cm(-2) as determined by etch pit density (EPD) measurements have been obtained by thermal cyclic annealing (TCA). The reduction of the dislocation density by TCA has led to a simple rate-equation-based model to explain the relationship between dislocation density and TCA parameters (time, temperature, and number of anneals). In this model, dislocation density reduction is based on dislocation coalescence and annihilation, assumed to be caused by dislocation motion under thermal and misfit stress. An activation energy for dislocation motion in n-type (112)B HgCdTe/Si of 0.93 +/- A 0.1 eV was determined. This model with no adjustable parameters was used to predict recent TCA annealing results. C1 [Benson, J. D.; Bubulac, L. O.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Farrell, S.; Brill, G.; Chen, Y.; Wijewarnasuriya, P. S.; Lee, U.] USA, Res Lab, Adelphi, MD USA. [Vilela, M. F.; Peterson, J.; Johnson, S. M.; Lofgreen, D. D.; Rhiger, D.; Patten, E. A.; Goetz, P. M.] Raytheon Vis Syst, Golta, CA USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM david.j.benson@us.army.mil RI Brill, Gregory/G-4877-2013 NR 27 TC 11 Z9 12 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2011 VL 40 IS 8 BP 1847 EP 1853 DI 10.1007/s11664-011-1670-5 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 788SZ UT WOS:000292466000038 ER PT J AU Eslam, M Khattab, MA Harrison, SA AF Eslam, Mohammed Khattab, Mahmoud AboElneen Harrison, Stephen A. TI Insulin resistance and hepatitis C: an evolving story SO GUT LA English DT Article ID VIRUS CORE PROTEIN; PROLIFERATOR-ACTIVATED-RECEPTOR; TYPE-2 DIABETES-MELLITUS; SUSTAINED VIROLOGICAL RESPONSE; LIVER-TRANSPLANT RECIPIENTS; ALPHA-2B PLUS RIBAVIRIN; NECROSIS-FACTOR-ALPHA; GENOTYPE 4 PATIENTS; HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS AB Insulin resistance and diabetes are inextricably linked to chronic hepatitis C. Our understanding of this relationship continues to improve. This review focuses on the molecular mechanisms relating insulin resistance to hepatitis C with a subsequent overview of the consequences of hepatitis C-associated insulin resistance and diabetes, as well as perspectives for future management. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Eslam, Mohammed; Khattab, Mahmoud AboElneen] Menia Univ, Dept Internal Med, Al Minya, Egypt. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil FU Genentech; Merck; Rottapharm FX SAH: Research support from Genentech, Merck and Rottapharm; Ad Hoc Advisory Board for Three Rivers Pharmaceuticals; Speaker's bureau for Bristol Myers Squibb. NR 168 TC 29 Z9 30 U1 1 U2 2 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD AUG PY 2011 VL 60 IS 8 BP 1139 EP 1151 DI 10.1136/gut.2010.228262 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 786OQ UT WOS:000292318200021 PM 21252203 ER PT J AU Becker, R AF Becker, Richard TI An alternative approach to integrating plasticity relations SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Non-quadratic; Plasticity integration; Flow potential ID YIELD CRITERION; MODELS AB A new plasticity integration algorithm is proposed based upon observations from the closed form integration of a generalized quadratic yield function over a single time step. The key to the approach is specification of the normal to the plastic flow potential as a function of the current state and strain increment. This uniquely defines the direction of the stress tensor for a convex, non-faceted flow potential. The stress magnitude and plastic strain increment are computed to satisfy the yield function. A non-quadratic, isotropic, associative flow model is coded to demonstrate accuracy and time step convergence following a step change in loading path. The model is used in additional simulations of strain localization in an expanding ring and a perforated plate. Published by Elsevier Ltd. C1 USA, Res Lab, High Rate Mech & Failure Branch, Aberdeen Proving Ground, MD 21005 USA. RP Becker, R (reprint author), USA, Res Lab, High Rate Mech & Failure Branch, Aberdeen Proving Ground, MD 21005 USA. EM richard.c.becker@us.army.mil RI Becker, Richard/I-1196-2013 NR 23 TC 4 Z9 4 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 J9 INT J PLASTICITY JI Int. J. Plast. PD AUG PY 2011 VL 27 IS 8 BP 1224 EP 1238 DI 10.1016/j.ijplas.2011.01.005 PG 15 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 781DC UT WOS:000291909800005 ER PT J AU Wang, WY Fang, HZ Shang, SL Zhang, H Wang, Y Hui, X Mathaudhu, S Liu, ZK AF Wang, W. Y. Fang, H. Z. Shang, S. L. Zhang, H. Wang, Y. Hui, X. Mathaudhu, S. Liu, Z. K. TI Atomic structure and diffusivity in liquid Al80Ni20 by ab initio molecular dynamics simulations SO PHYSICA B-CONDENSED MATTER LA English DT Article DE Diffusivity; Liquid Al80Ni20; AIMD; Short range order ID TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; BULK METALLIC-GLASS; SUPERCOOLED LIQUID; NEUTRON-DIFFRACTION; PHASE-TRANSITION; BINARY-ALLOYS; RANGE ORDER; BASIS-SET; NI AB The atomic structure and diffusivity in liquid Al80Ni20 are studied by ab initio molecular dynamics simulations. The local structures are analyzed by the pair correlation function, structure factor, coordinate number, Honneycutt-Anderson bond pair, and Voronoi tessellation methods. It is observed that the amount of icosahedral clusters increases, and the liquid becomes more ordered as the temperature decreases. The predicted self-diffusion coefficients of Al and Ni via the mean square displacements are very close to each other and agree well with the quasi-elastic neutron scattering measurements in the literature. The observation of equal self-diffusivity of Al and Ni is attributed to the formation of local solute-centered polyhedra, coupling the migration of Al and Ni. The Manning dynamic correlation factor is evaluated and found to be close to unity. The predicted interdiffusion coefficients using the Darken equation agree well with experimental data in the literature. (C) 2011 Elsevier B.V. All rights reserved. C1 [Wang, W. Y.; Fang, H. Z.; Shang, S. L.; Zhang, H.; Wang, Y.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Hui, X.] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China. [Mathaudhu, S.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yuw129@psu.edu RI Mathaudhu, Suveen/B-4192-2009; Wang, William Yi/F-8212-2011; Shang, Shun-Li/A-6564-2009; Hui, Xidong/A-1741-2010; Wang, Yi/D-1032-2013; Fang, Huazhi/L-6126-2013; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Shang, Shun-Li/0000-0002-6524-8897; Fang, Huazhi/0000-0002-4561-6971; Liu, Zi-Kui/0000-0003-3346-3696 FU National Science Foundation [DMR-1006557]; Army Research Laboratory in the Unites States [W911NF-08-2-0064]; National Natural Science Foundation of China [50431030, 50871013]; National Basic Research Program of China [2007CB613901]; China Scholarship Council; American Academic Exchange Service [3072]; Materials Simulation Center; Research Computing and Cyberinfrastructure unit at the Pennsylvania State University; NSF [CISE-0202007, OCI-0821527] FX This work was financially supported by the National Science Foundation (Grant no. DMR-1006557) and the Army Research Laboratory (Contract no. W911NF-08-2-0064) in the Unites States, National Natural Science Foundation of China (Grant nos. 50431030 and 50871013), and National Basic Research Program of China (Grant no. 2007CB613901). W.Y. Wang acknowledges the support from the Project Based Personnel Exchange Program with China Scholarship Council and American Academic Exchange Service ([2008] 3072). First-principles calculations were carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Research Computing and Cyberinfrastructure unit at the Pennsylvania State University. Calculations were also carried out on the INTI clusters from the Computer Science Department at Pennsylvania State University supported by NSF under Grant no. CISE-0202007 and CyberStar cluster funded by NSF through grant OCI-0821527. NR 67 TC 16 Z9 16 U1 6 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4526 J9 PHYSICA B JI Physica B PD AUG PY 2011 VL 406 IS 15-16 BP 3089 EP 3097 DI 10.1016/j.physb.2011.05.013 PG 9 WC Physics, Condensed Matter SC Physics GA 786JK UT WOS:000292302700027 ER PT J AU Kelly, EP Polo, S Sun, W Falgout, B AF Kelly, Eileen P. Polo, Stephanie Sun, Wellington Falgout, Barry TI Evolution of attenuating mutations in dengue-2 strain S16803 PDK50 vaccine and comparison of growth kinetics with parent virus SO VIRUS GENES LA English DT Article DE Dengue virus; Vaccine mutation analysis; Infectious clone ID TICK-BORNE ENCEPHALITIS; AMINO-ACID SUBSTITUTION; DOUBLE-STRANDED-RNA; DOG KIDNEY-CELLS; WEST-NILE-VIRUS; ENVELOPE GLYCOPROTEIN; NS1 PROTEIN; VIRAL-RNA; NONSTRUCTURAL PROTEINS; HEMORRHAGIC-FEVER AB A live-attenuated dengue-2 virus strain S16803 vaccine candidate that is immunogenic and safe in humans was derived by 50 passages in primary dog kidney (PDK) cells. To identify mutations associated with attenuation of the dengue-2 PDK50 vaccine strain, we determined the nucleotide changes that arose during PDK passage of the dengue-2 virus. Thirteen mutations distinguished the PDK50 virus from low-passage parent resulting in amino acid substitutions in the premembrane (E89G), envelope (E202K, N203D), nonstructural proteins NS1 (A43T), NS2A (L181F), NS2B (I26V), and NS4B (I/T108T, L112F). In addition, the PDK50 virus contained a C to T change of nucleotide 57 in the 5' non-coding region and four silent mutations of nucleotides 591, 987, 6471, and 8907. An infectious PDK50 cDNA clone virus was produced and characterized for growth kinetics in monkey (LLC-MK(2), Vero) and mosquito (C6/36) cells. Identification of mutations in the vaccine strain and availability of an infectious clone will permit systematic analysis of the importance of individual or collective mutations on attenuation of dengue virus. C1 [Kelly, Eileen P.] Walter Reed Army Inst Res, Div Virus Dis, Silver Spring, MD 20910 USA. [Polo, Stephanie; Sun, Wellington; Falgout, Barry] US FDA, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA. RP Kelly, EP (reprint author), Walter Reed Army Inst Res, Div Virus Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM eileen.kelly@amedd.army.mil FU United States Army Medical Research and Materiel Command FX The authors would like to thank Dr. Ken Eckels, Walter Reed Army Institute of Research, for providing the lyophilized low-passage parent and PDK10, PDK30, PDK40 and PDK50 vaccine candidate viruses. The studies were supported by the United States Army Medical Research and Materiel Command. NR 53 TC 5 Z9 5 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD AUG PY 2011 VL 43 IS 1 BP 18 EP 26 DI 10.1007/s11262-011-0602-z PG 9 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 784LN UT WOS:000292158900004 PM 21461924 ER PT J AU Huang, JH Durden, H Chowdhury, M AF Huang, Jinhua Durden, Helen Chowdhury, Mostafiz TI Bio-inspired armor protective material systems for ballistic shock mitigation SO MATERIALS & DESIGN LA English DT Article DE Foams; Impact and ballistic; Coupon testing AB Severe transient ballistic shocks from projectile impacts, mine blasts, or overhead artillery attacks can incapacitate an occupant at low frequencies, or sensitive equipment at high frequencies, if they are not properly attenuated by armor protective systems. Unique challenges exist in developing armor protective systems for mitigating both low and high frequency ballistic shocks due to the lack of robust design methodology, the severe dynamic loading conditions, and the uncertainties in predicting ballistic shock responses. Nature offers engineers a blueprint of highly effective, efficient, and adaptive material designs to protect certain regions from external threats. This paper presents the modeling, analysis, design, optimization, fabrication, and experimental validation of bone-inspired armor protective material systems for reducing projectile penetrations and alleviating ballistic shocks at both low and high frequencies. The optimized bone-inspired armor protective material system has a soft-stiff-soft-stiff material distribution pattern based on bone-foramen and osteonal-bone material systems. Analysis and experimental results demonstrated that the bone-inspired armor protective material systems have excellent capabilities for drastic ballistic shock mitigation, weight savings, and significant reductions in penetration and load transmission under ballistic loading conditions. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Huang, Jinhua; Durden, Helen] M4 Engn Inc, Long Beach, CA 90807 USA. [Chowdhury, Mostafiz] USA, Res Lab Liaison, Arlington, VA 22202 USA. RP Huang, JH (reprint author), M4 Engn Inc, 4020 Long Beach Blvd, Long Beach, CA 90807 USA. EM jhuang@m4-engineering.com FU Army Research Laboratory via the M4 Engineering Inc.; SBIR [W911QX-10-C-0043] FX Research presented in this paper is funded through Army Research Laboratory via the M4 Engineering Inc., SBIR Contract W911QX-10-C-0043: Bone-Foramen-Inspired Material System for Ballistic Shock Mitigation. NR 19 TC 5 Z9 5 U1 4 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0261-3069 J9 MATER DESIGN JI Mater. Des. PD AUG PY 2011 VL 32 IS 7 BP 3702 EP 3710 DI 10.1016/j.matdes.2011.03.061 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA 770YT UT WOS:000291125100005 ER PT J AU Cassenti, DN AF Cassenti, Daniel N. TI The intrinsic link between motor behavior and temporal cognition SO NEW IDEAS IN PSYCHOLOGY LA English DT Article DE Cognitive processes; Motor skills; Time perception; Neuroanatomy ID DUAL-TASK PERFORMANCE; SHORT-TERM-MEMORY; BRAIN ACTIVATION; TIME PERCEPTION; WORKING-MEMORY; INTERNAL CLOCK; ARM MOVEMENTS; WORD-LENGTH; AUTOMATICITY; ATTENTION AB The debate about the cognitive mechanisms behind human temporal processing has raged for decades without a clear resolution. The theory presented here describes a different perspective to the traditional accounts on the issue, namely, that motor behaviors or sequences of motor behaviors provide a means of reproducing time intervals. Evidence behind this perspective includes tapping strategies (exemplified by musicians), counting strategies, and neuropsychological results showing activation of motor areas during temporal cognitive tasks. I propose that motor behaviors aid human timing by offering a set of processes that consistently take a set amount of time to accomplish. Motor behaviors also allow segmentation of larger intervals into smaller intervals that are easier to estimate. I conclude with a discussion of implications of this perspective on temporal cognition. Published by Elsevier Ltd. C1 USA, Res Lab, Human Res & Engn Directorate, RDRL HRS E, Aberdeen Proving Ground, MD 21005 USA. RP Cassenti, DN (reprint author), USA, Res Lab, Human Res & Engn Directorate, RDRL HRS E, Aberdeen Proving Ground, MD 21005 USA. EM daniel.cassenti@us.army.mil NR 64 TC 5 Z9 5 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0732-118X J9 NEW IDEAS PSYCHOL JI New Ideas Psychol. PD AUG PY 2011 VL 29 IS 2 BP 72 EP 79 DI 10.1016/j.newideapsych.2010.03.011 PG 8 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 734DG UT WOS:000288312800003 ER PT J AU Son, JS Appleford, M Ong, JL Wenke, JC Kim, JM Choi, SH Oh, DS AF Son, Jun Sik Appleford, Mark Ong, Joo L. Wenke, Joseph C. Kim, Jong Min Choi, Seok Hwa Oh, Daniel S. TI Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres SO JOURNAL OF CONTROLLED RELEASE LA English DT Article DE Hydroxyapatite; Poly(lactic-co-glycolic acid); Drug delivery system; Scaffold; Microsphere; Dexamethasone ID CALCIUM-PHOSPHATE SCAFFOLDS; OSTEOBLAST PRECURSOR CELLS; OXYGEN PLASMA TREATMENT; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; SUSTAINED-RELEASE; GENE DELIVERY; IN-VIVO; POLYMERIC MICROSPHERES; COMPOSITE SCAFFOLDS AB In this study, ionic immobilization of dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres was performed on the hydroxyapatite (HAp) scaffold surfaces. It was hypothesized that in vivo bone regeneration could be enhanced with HAp scaffolds containing DEX-loaded PLGA microspheres compared to the use of HAp scaffolds alone. In vitro drug release from the encapsulated microspheres was measured prior to the implantation in the femur defects of beagle dogs. It was observed that porous, interconnected HAp scaffolds as well as DEX-loaded PLGA microspheres were successfully fabricated in this study. Additionally. PEI was successfully coated on PLGA microsphere surfaces, resulting in a net positive-charged surface. With such modification of the PLGA microsphere surfaces, DEX-loaded PLGA microspheres were immobilized on the negatively charged HAp scaffold surfaces. Release profile of DEX over a 4 week immersion study indicated an initial burst release followed by a sustained release. In vivo evaluation of the defects filled with DEX-loaded HAp scaffolds indicated enhanced volume and quality of new bone formation when compared to defects that were either unfilled or filled with HAp scaffolds alone. This innovative platform for bioactive molecule delivery more potently induced osteogenesis in vivo, which may be exploited in implantable bone graft substitutes for stem cell therapy or improved in vivo performance. It was thus concluded that various bioactive molecules for bone regeneration might be efficiently incorporated with calcium phosphate-based bioceramics using biodegradable polymeric microspheres. Published by Elsevier B.V. C1 [Son, Jun Sik; Appleford, Mark; Ong, Joo L.; Oh, Daniel S.] Univ Texas San Antonio, San Antonio, TX 78249 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houstion, TX USA. [Kim, Jong Min; Choi, Seok Hwa] Chungbuk Natl Univ, Coll Vet Med, Cheongju, South Korea. RP Choi, SH (reprint author), Univ Texas San Antonio, San Antonio, TX 78249 USA. EM shchoi@cbu.ac.kr; Daniel.oh@utsa.edu OI CHOI, Seok Hwa/0000-0002-7003-3655 FU Department of Defense; Orthopaedic Extremity Trauma Research Program [W81XWH-08-1-0393, W81XWH-07-1-0717] FX This study was supported in part by the Department of Defense funds and the Orthopaedic Extremity Trauma Research Program grants (USAMRMC # W81XWH-08-1-0393 and W81XWH-07-1-0717). NR 48 TC 63 Z9 66 U1 3 U2 74 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 EI 1873-4995 J9 J CONTROL RELEASE JI J. Control. Release PD JUL 30 PY 2011 VL 153 IS 2 BP 133 EP 140 DI 10.1016/j.jconrel.2011.03.010 PG 8 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 799UZ UT WOS:000293312900005 PM 21420453 ER PT J AU Sviatenko, L Isayev, O Gorb, L Hill, F Leszczynski, J AF Sviatenko, Liudmila Isayev, Olexandr Gorb, Leonid Hill, Frances Leszczynski, Jerzy TI Toward Robust Computational Electrochemical Predicting the Environmental Fate of Organic Pollutants SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE redox potential; DFT calculations; organic pollutants; electrochemistry; solvation ID 2-ELECTRON REDUCTION POTENTIALS; ELECTRON REDOX POTENTIALS; SOLVATION FREE-ENERGIES; QUINONE DERIVATIVES; AQUEOUS-SOLUTION; CONTINUUM MODEL; IRON; COMPLEXES; DECHLORINATION; CONTAMINANTS AB A number of density functionals was utilized for the calculation of electron attachment free energy for nitrocompounds, quinones and azacyclic compounds. Different solvation models have been tested on the calculation of difference in free energies of solvation of oxidized and reduced forms of nitrocompounds in aqueous solution, quinones in acetonitrile, and azacyclic compounds in dimethylformamide. Gas-phase free energies evaluated at the mPWB1K/tzvp level and solvation energies obtained using SMD model to compute solvation energies of neutral oxidized forms and PCM(Pauling) to compute solvation energies of anion-radical reduced forms provide reasonable accuracy of the prediction of electron attachment free energy, difference in free solvation energies of oxidized and reduced forms, and as consequence yield reduction potentials in good agreement with experimental data (mean absolute deviation is 0.15 V). It was also found that SMD/M05-2X/tzvp method provides reduction potentials with deviation of 0.12 V from the experimental values but in cases of nitrocompounds and quinones this accuracy is achieved due to the cancelation of errors. To predict reduction ability of naturally occurred iron containing species with respect to organic pollutants we exploited experimental data within the framework of Pourbaix (E-h - pH) diagrams. We conclude that surface-bound Fe(II) as well as certain forms of aqueous Fe(II)(aq) are capable of reducing a variety of nitroaromatic compounds, quinones and novel high energy materials under basic conditions (pH > 8). At the same time, zero-valent iron is expected to be active under neutral and acidic conditions. (C) 2011 Wiley Periodicals, Inc. J Comput Chem 32: 2195-2203, 2011 C1 [Sviatenko, Liudmila; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Sviatenko, Liudmila] Kirovograd State Pedag Univ, Kirovograd, Ukraine. [Isayev, Olexandr] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. [Gorb, Leonid] SpecPro Inc, Huntsville, AL 35805 USA. [Hill, Frances; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org RI Isayev, Olexandr/B-7944-2008; Tunega, Daniel/B-3767-2015 OI Isayev, Olexandr/0000-0001-7581-8497; FU NSF-CREST [HRD-0833178]; United States Army Corps of Engineers; USAERDC FX Contract/grant sponsor: NSF-CREST; contract/grant numbers: HRD-0833178; The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from the research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 61 TC 27 Z9 27 U1 2 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD JUL 30 PY 2011 VL 32 IS 10 BP 2195 EP 2203 DI 10.1002/jcc.21803 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA 770TR UT WOS:000291111900015 PM 21541957 ER PT J AU Dow, GS Gettayacamin, M Hansukjariya, P Imerbsin, R Komcharoen, S Sattabongkot, J Kyle, D Milhous, W Cozens, S Kenworthy, D Miller, A Veazey, J Ohrt, C AF Dow, Geoffrey S. Gettayacamin, Montip Hansukjariya, Pranee Imerbsin, Rawiwan Komcharoen, Srawuth Sattabongkot, Jetsumon Kyle, Dennis Milhous, Wilbur Cozens, Simon Kenworthy, David Miller, Anne Veazey, Jim Ohrt, Colin TI Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta) SO MALARIA JOURNAL LA English DT Article ID VIVAX MALARIA; FALCIPARUM-MALARIA; ANTIMALARIAL-DRUGS; CHLOROQUINE; PRIMAQUINE; PHARMACOKINETICS; WR-238605; RELAPSE; BLOOD AB Background: Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combination with other antimalarials may mitigate these concerns. Methods: In 2005, the radical curative efficacy of tafenoquine combinations was investigated in Plasmodium cynomolgi-infected naive Indian-origin Rhesus monkeys. In the first cohort, groups of two monkeys were treated with a three-day regimen of tafenoquine at different doses alone and in combination with a three-day chloroquine regimen to determine the minimum curative dose (MCD). In the second cohort, the radical curative efficacy of a single-day regimen of tafenoquine-mefloquine was compared to that of two three-day regimens comprising tafenoquine at its MCD with chloroquine or artemether-lumefantrine in groups of six monkeys. In a final cohort, the efficacy of the MCD of tafenoquine against hypnozoites alone and in combination with chloroquine was investigated in groups of six monkeys after quinine pre-treatment to eliminate asexual parasites. Plasma tafenoquine, chloroquine and desethylchloroquine concentrations were determined by LC-MS in order to compare doses of the drugs to those used clinically in humans. Results: The total MCD of tafenoquine required in combination regimens for radical cure was ten-fold lower (1.8 mg/kg versus 18 mg/kg) than for monotherapy. This regimen (1.8 mg/kg) was equally efficacious as monotherapy or in combination with chloroquine after quinine pre-treatment to eliminate asexual stages. The same dose of (1.8 mg/kg) was radically curative in combination with artemether-lumefantrine. Tafenoquine was also radically curative when combined with mefloquine. The MCD of tafenoquine monotherapy for radical cure (18 mg/kg) appears to be biologically equivalent to a 600-1200 mg dose in humans. At its MCD in combination with blood schizonticidal drugs (1.8 mg/kg), the maximum observed plasma concentrations were substantially lower than (20-84 versus 550-1,100 ng/ml) after administration of 1, 200 mg in clinical studies. Conclusions: Ten-fold lower clinical doses of tafenoquine than used in prior studies may be effective against P. vivax hypnozoites if the drug is deployed in combination with effective blood-schizonticidal drugs. C1 [Dow, Geoffrey S.; Ohrt, Colin] Walter Reed Army Inst Res, Dept Expt Therapeut, Silver Spring, MD 20910 USA. [Gettayacamin, Montip; Imerbsin, Rawiwan; Komcharoen, Srawuth] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Kyle, Dennis; Milhous, Wilbur] Univ S Florida, Coll Publ Hlth, Tampa, FL 33612 USA. [Cozens, Simon; Kenworthy, David] GlaxoSmithKline R&D, Drug Metab & Pharmacokinet, Ware SG12 0DP, Herts, England. [Miller, Anne] GlaxoSmithKline Inc, QSi, CPMS, King Of Prussia, PA 19406 USA. [Veazey, Jim] USA, Med Mat Dev Act MCMR UMP, Ft Detrick, MD 21702 USA. RP Ohrt, C (reprint author), Walter Reed Army Inst Res, Dept Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM colin.ohrt@us.army.mil FU National Institute of Allergy and Infectious Diseases [RC1AI048874-01, UC1AI049499-01] FX This work was supported in part through by the Military Infectious Diseases research Program and grant #s RC1AI048874-01 and UC1AI049499-01 from the National Institute of Allergy and Infectious Diseases. NR 24 TC 24 Z9 24 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUL 29 PY 2011 VL 10 AR 212 DI 10.1186/1475-2875-10-212 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 812AY UT WOS:000294261300001 PM 21801400 ER PT J AU Chattopadhyay, R de la Vega, P Paik, SH Murata, Y Ferguson, EW Richie, TL Ooi, GT AF Chattopadhyay, Rana de la Vega, Patricia Paik, Sun H. Murata, Yoko Ferguson, Earl W. Richie, Thomas L. Ooi, Guck T. TI Early Transcriptional Responses of HepG2-A16 Liver Cells to Infection by Plasmodium falciparum Sporozoites SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HUMAN HEPATOCELLULAR-CARCINOMA; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE ANTIBODIES; GLYPICAN-3 EXPRESSION; INVITRO CULTURE; GENE-EXPRESSION; T-CELLS; MALARIA; STAGE; VIVAX AB Invasion of hepatocytes by Plasmodium sporozoites deposited by Anopheles mosquitoes, and their subsequent transformation into infective merozoites is an obligatory step in the initiation of malaria. Interactions between the sporozoites and hepatocytes lead to a distinct, complex and coordinated cellular and systemic host response. Little is known about host liver cell response to sporozoite invasion, or whether it is primarily adaptive for the parasite, for the host, or for both. Our present study used gene expression profiling of human HepG2-A16 liver cells infected with Plasmodium falciparum sporozoites to understand the host early cellular events and factors influencing parasite infectivity and sporozoite development. Our results show that as early as 30 min following wild-type, non-irradiated sporozoite exposure, the expressions of at least 742 genes was selectively altered. These genes regulate diverse biological functions, such as immune processes, cell adhesion and communications, metabolism pathways, cell cycle regulation, and signal transduction. These functions reflect cellular events consistent with initial host cell defense responses, as well as alterations in host cells to sustain sporozoites growth and survival. Irradiated sporozoites gave very similar gene expression pattern changes, but direct comparative analysis between liver gene expression profiles caused by irradiated and non-irradiated sporozoites identified 29 genes, including glypican-3, that were specifically up-regulated only in irradiated sporozoites. Elucidating the role of this subset of genes may help identify the molecular basis for the irradiated sporozoites inability to develop intrahepatically, and their usefulness as an immunogen for developing protective immunity against pre-erythrocytic stage malaria. C1 [Chattopadhyay, Rana; de la Vega, Patricia; Richie, Thomas L.] US Mil Malaria Vaccine Program, Malaria Program, Silver Spring, MD 20910 USA. [de la Vega, Patricia] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Richie, Thomas L.] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Paik, Sun H.; Murata, Yoko; Ferguson, Earl W.; Ooi, Guck T.] Sun BioMed Technol Inc, Ridgecrest, CA 93555 USA. RP Chattopadhyay, R (reprint author), US FDA, Div Vaccines & Related Prod Applicat, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA. EM rana.chattopadhyay@fda.hhs.gov; guckooi@sunbmt.com OI Richie, Thomas/0000-0002-2946-5456 FU Department of Defense [W81XWH-05-C-0030]; CRADA [LP-CRADA-NMRC-05-2107, 6000.RAD1.F.A0309] FX This work was supported by Department of Defense Small Business Innovative Research Grant W81XWH-05-C-0030 (to S. H. P., Y. M., E. W. F., and G. T. O.) and the work between Sun BioMedical Technologies and the Malaria Program, Naval Medical Research Center was conducted through a CRADA collaboration Grant LP-CRADA-NMRC-05-2107 and was supported by Grant 6000.RAD1.F.A0309 (to R. C., P. V., and T. L. R.). NR 64 TC 8 Z9 8 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JUL 29 PY 2011 VL 286 IS 30 BP 26396 EP 26405 DI 10.1074/jbc.M111.240879 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 796UK UT WOS:000293078200017 PM 21652718 ER PT J AU Izvekov, S Chung, PW Rice, BM AF Izvekov, Sergei Chung, Peter W. Rice, Betsy M. TI Particle-based multiscale coarse graining with density-dependent potentials: Application to molecular crystals (hexahydro-1,3,5-trinitro-s-triazine) SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article DE free energy; interpolation; organic semiconductors; vibrational states ID EQUATION-OF-STATE; DYNAMICS SIMULATIONS; FORCE-FIELD; SYSTEMS; NITROMETHANE; HMX; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-S-TRIAZINE; PRESSURES; SILICON; FLUID AB We describe the development of isotropic particle-based coarse-grain models for crystalline hexahydro-1,3,5-trinitro-s-triazine (RDX). The coarse graining employs the recently proposed multiscale coarse-graining (MS-CG) method, which is a particle-based force-matching approach for deriving free-energy effective interaction potentials. Though one-site and four-site coarse-grain (CG) models were parameterized from atomistic simulations of non-ordered (molten and ambient temperature amorphous) systems, the focus of the paper is a detailed study of the one-site model with a brief recourse to the four-site model. To improve the ability of the one-site model to be applied to crystalline phases at various pressures, it was found necessary to include explicit dependence on a particle density, and a new theory of local density-dependent MS-CG potentials is subsequently presented. The density-dependency is implemented through interpolation of MS-CG force fields derived at a preselected set of reference densities. The computationally economical procedure for obtaining the reference force fields starting from the interaction at ambient density is also described. The one-site MS-CG model adequately describes the atomistic lattice structure of alpha-RDX at ambient and high pressures, elastic and vibrational properties, pressure-volume curve up to P = 10 GPa, and the melting temperature. In the molten state, the model reproduces the correct pair structure at different pressures as well as higher order correlations. The potential of the MS-CG model is further evaluated in simulations of shocked crystalline RDX. [doi:10.1063/1.3607603] C1 [Izvekov, Sergei; Chung, Peter W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov@us.army.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr. John Brennan and Ms. Sarah Hamdan for helpful comments. This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. Computing support was provided by the DoD Supercomputer Resource Center. NR 66 TC 22 Z9 22 U1 1 U2 33 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUL 28 PY 2011 VL 135 IS 4 AR 044112 DI 10.1063/1.3607603 PG 17 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 801YU UT WOS:000293477300013 PM 21806095 ER PT J AU Mease, LE Coldren, RL Musila, LA Prosser, T Ogolla, F Ofula, VO Schoepp, RJ Rossi, CA Adungo, N AF Mease, Luke E. Coldren, Rodney L. Musila, Lillian A. Prosser, Trish Ogolla, Fredrick Ofula, Victor O. Schoepp, Randal J. Rossi, Cindy A. Adungo, Nicholas TI Seroprevalence and distribution of arboviral infections among rural Kenyan adults: A cross-sectional study SO VIROLOGY JOURNAL LA English DT Article DE arbovirus; Kenya; flavivirus; dengue virus; West Nile virus; yellow fever virus; chikungunya virus; Rift Valley fever virus ID RIFT-VALLEY FEVER; ONYONG NYONG VIRUS; CHIKUNGUNYA-VIRUS; YELLOW-FEVER; NORTHEASTERN KENYA; OUTBREAK; ANTIBODIES; DISEASES; PREVALENCE; EVOLUTION AB Background: Arthorpod-borne viruses (arboviruses) cause wide-spread morbidity in sub-Saharan Africa, but little research has documented the burden and distribution of these pathogens. Methods: Using a population-based, cross-sectional study design, we administered a detailed questionnaire and used ELISA to test the blood of 1,141 healthy Kenyan adults from three districts for the presence of anti-viral Immunoglobulin G (IgG) antibodies to the following viruses: dengue (DENV), West Nile (WNV), yellow fever (YFV), Chikungunya (CHIKV), and Rift Valley fever (RVFV). Results: Of these, 14.4% were positive for DENV, 9.5% were WNV positive, 9.2% were YFV positive, 34.0% were positive for CHIKV and 0.7% were RVFV positive. In total, 46.6% had antibodies to at least one of these arboviruses. Conclusions: For all arboviruses, district of residence was strongly associated with seropositivity. Seroprevalence to YFV, DENV and WNV increased with age, while there was no correlation between age and seropositivity for CHIKV, suggesting that much of the seropositivity to CHIKV is due to sporadic epidemics. Paradoxically, literacy was associated with increased seropositivity of CHIKV and DENV. C1 [Mease, Luke E.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Mease, Luke E.; Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Musila, Lillian A.; Ofula, Victor O.] Kenya Govt Med Res Ctr, US Army Med Res Unit Kenya, Dept Emerging Infect Dis, Nairobi, Kenya. [Prosser, Trish] USA, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Ogolla, Fredrick; Adungo, Nicholas] Kenya Govt Med Res Ctr, Ctr Infect & Parasit Dis Control Res, Busia, Kenya. [Schoepp, Randal J.; Rossi, Cindy A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Mease, LE (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM luke.mease@us.army.mil RI Valle, Ruben/A-7512-2013 NR 32 TC 29 Z9 29 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUL 27 PY 2011 VL 8 AR 371 DI 10.1186/1743-422X-8-371 PG 8 WC Virology SC Virology GA 815UC UT WOS:000294554200001 PM 21794131 ER PT J AU Sessums, LL Zembrzuska, H Jackson, JL AF Sessums, Laura L. Zembrzuska, Hanna Jackson, Jeffrey L. TI Does This Patient Have Medical Decision-Making Capacity? SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID MACARTHUR TREATMENT COMPETENCE; PHYSICIANS LEGAL STANDARD; TRAUMATIC BRAIN-INJURY; MENTALLY-ILL PATIENTS; LONG-TERM-CARE; ALZHEIMERS-DISEASE; INFORMED-CONSENT; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; PERSONAL JUDGMENTS AB Context Evaluation of the capacity of a patient to make medical decisions should occur in the context of specific medical decisions when incapacity is considered. Objective To determine the prevalence of incapacity and assessment accuracy in adult medicine patients without severe mental illnesses. Data Sources MEDLINE and EMBASE (from their inception through April 2011) and bibliographies of retrieved articles. Study Selection We included high-quality prospective studies (n=43) of instruments that evaluated medical decision-making capacity for treatment decisions. Data Extraction Two authors independently appraised study quality, extracted relevant data, and resolved disagreements by consensus. Data Synthesis Incapacity was uncommon in healthy elderly control participants (2.8%; 95% confidence interval [CI], 1.7%-3.9%) compared with medicine inpatients (26%; 95% CI, 18%-35%). Clinicians accurately diagnosed incapacity (positive likelihood ratio [LR+] of 7.9; 95% CI, 2.7-13), although they recognized it in only 42% (95% CI, 30%-53%) of affected patients. Although not designed to assess incapacity, Mini-Mental State Examination (MMSE) scores less than 20 increased the likelihood of incapacity (LR, 6.3; 95% CI, 3.7-11), scores of 20 to 24 had no effect (LR, 0.87; 95% CI, 0.53-1.2), and scores greater than 24 significantly lowered the likelihood of incapacity (LR, 0.14; 95% CI, 0.06-0.34). Of 9 instruments compared with a gold standard, only 3 are easily performed and have useful test characteristics: the Aid to Capacity Evaluation (ACE) (LR+, 8.5; 95% CI, 3.9-19; negative LR [LR-], 0.21; 95% CI, 0.11-0.41), the Hopkins Competency Assessment Test (LR+, 54; 95% CI, 3.5-846; LR-, 0; 95% CI, 0.0-0.52), and the Understanding Treatment Disclosure (LR+, 6.0; 95% CI, 2.1-17; LR-, 0.16; 95% CI, 0.06-0.41). The ACE was validated in the largest study; it is freely available online and includes a training module. Conclusions Incapacity is common and often not recognized. The MMSE is useful only at extreme scores. The ACE is the best available instrument to assist physicians in making assessments of medical decision-making capacity. JAMA. 2011; 306(4): 420-427 C1 [Sessums, Laura L.; Zembrzuska, Hanna] Walter Reed Army Med Ctr, Gen Internal Med Sect, Washington, DC 20307 USA. [Jackson, Jeffrey L.] Zablocki VA Med Ctr, Div Gen Internal Med, Milwaukee, WI USA. [Jackson, Jeffrey L.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. RP Sessums, LL (reprint author), Walter Reed Army Med Ctr, Gen Internal Med Sect, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM laura.sessums@us.army.mil NR 71 TC 71 Z9 72 U1 4 U2 28 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 27 PY 2011 VL 306 IS 4 BP 420 EP 427 DI 10.1001/jama.2011.1023 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 797KL UT WOS:000293125800028 PM 21791691 ER PT J AU Nee, R Hurst, FP Dharnidharka, VR Jindal, RM Agodoa, LY Abbott, KC AF Nee, Robert Hurst, Frank P. Dharnidharka, Vikas R. Jindal, Rahul M. Agodoa, Lawrence Y. Abbott, Kevin C. TI Racial Variation in the Development of Posttransplant Lymphoproliferative Disorders After Renal Transplantation SO TRANSPLANTATION LA English DT Article DE United States Renal Data System; Renal transplantation; Cancer ID PEDIATRIC KIDNEY-TRANSPLANTATION; BARR-VIRUS INFECTION; NON-HODGKIN-LYMPHOMA; UNITED-STATES; RISK-FACTORS; COLLABORATIVE TRANSPLANT; MODERN IMMUNOSUPPRESSION; ALLOGRAFT RECIPIENTS; GRAFT-SURVIVAL; DISEASE AB Background. We previously reported that posttransplant lymphoproliferative disorders (PTLD) occurred more frequently in non-African American (AF) kidney transplant recipients. An in-depth analysis of racial differences in the development of PTLD has not been reported. Methods. We assessed Medicare claims for PTLD in a retrospective cohort of 53,719 patients who underwent transplantation from January 2000 to September 2006 and followed up through December 2007. Results. There were 719 (1.3%) patients with claims for PTLD. Non-AF recipient race (including all races analyzed separately, adjusted hazard ratio [AHR] 1.38, 95% confidence interval [CI] 1.13-1.68), recipient Epstein-Barr virus (EBV) immunoglobulin G (IgG) seronegative status (AHR 1.88, 95% CI 1.53-2.34), and de novo sirolimus (AHR 1.22, 95% CI 1.03-1.45) were associated with an increased risk of PTLD. Furthermore, de novo sirolimus showed a significant interaction with EBV IgG; among EBV IgG-negative recipients, sirolimus use was significant (P=0.003), but among EBV IgG-positive recipients, it was not significant (P=0.18). EBV IgG-seronegative status was significant in all races except for AFs, and racial differences were a significant effect modifier for EBV IgG status and risk of PTLD. Mortality subsequent to PTLD did not differ by race. Conclusions. AF kidney transplant recipients were at lower risk for PTLD, irrespective of the recipient EBV IgG serostatus. On the contrary, recipient EBV IgG-seronegative status was associated with a higher risk of PTLD in the non-AF population. De novo sirolimus therapy was associated with increased risk of PTLD in EBV IgG-negative recipients, regardless of race. C1 [Nee, Robert] Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, Washington, DC 20307 USA. [Nee, Robert; Hurst, Frank P.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Dharnidharka, Vikas R.] Univ Florida, Coll Med, Div Pediat Nephrol, Gainesville, FL USA. [Dharnidharka, Vikas R.] Shands Childrens Hosp, Gainesville, FL USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. RP Nee, R (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM robert.nee@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 24 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUL 27 PY 2011 VL 92 IS 2 BP 190 EP 195 DI 10.1097/TP.0b013e3182200e8a PG 6 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 791AU UT WOS:000292633000016 PM 21577180 ER PT J AU Petrie, JR Fine, J Mandal, S Sreenivasulu, G Srinivasan, G Edelstein, AS AF Petrie, Jonathan R. Fine, Jonathan Mandal, Sanjay Sreenivasulu, Gollapudi Srinivasan, Gopalan Edelstein, Alan S. TI Enhanced sensitivity of magnetoelectric sensors by tuning the resonant frequency SO APPLIED PHYSICS LETTERS LA English DT Article ID ROOM-TEMPERATURE; MAGNETORESISTANCE AB The sensitivity of magnetoelectric (ME) sensors is more than an order of magnitude higher at their mechanical resonant frequency f(r). By applying a restoring torque to an asymmetric ME sensor, we have increased its effective stiffness and, thus, f(r) by 20% while maintaining the enhanced sensitivity at resonance. The torque was dependent on both the tensile force from a suspended weight and the length of the wire attaching it. This provides two alternative routes for tuning f(r) to optimize performance. We have detected fields below 10 pT at both the shifted and unshifted f(r) of 132.2 Hz. (C) 2011 American Institute of Physics. [doi:10.1063/1.3617428] C1 [Petrie, Jonathan R.; Fine, Jonathan; Edelstein, Alan S.] USA, Res Lab, Adelphi, MD 20783 USA. [Mandal, Sanjay; Sreenivasulu, Gollapudi; Srinivasan, Gopalan] Oakland Univ, Rochester, MI 48309 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alan.edelstein@us.army.mil OI Gollapudi, Sreenivasulu/0000-0002-6136-7119 FU DARPA FX The support for this project under the defense advanced research projects agency (DARPA) heterostructural uncooled magnetic sensors (HUMS) program is gratefully acknowledged. NR 17 TC 14 Z9 15 U1 0 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 25 PY 2011 VL 99 IS 4 AR 043504 DI 10.1063/1.3617428 PG 3 WC Physics, Applied SC Physics GA 801YC UT WOS:000293475500080 ER PT J AU Timmermans, ML Proshutinsky, A Krishfield, RA Perovich, DK Richter-Menge, JA Stanton, TP Toole, JM AF Timmermans, M-L. Proshutinsky, A. Krishfield, R. A. Perovich, D. K. Richter-Menge, J. A. Stanton, T. P. Toole, J. M. TI Surface freshening in the Arctic Ocean's Eurasian Basin: An apparent consequence of recent change in the wind-driven circulation SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID HEAT-FLUX; PACIFIC WATERS; CANADA BASIN; PACK ICE; SEA-ICE; VARIABILITY; HYDROGRAPHY; HALOCLINE; ATLANTIC; LAYER AB Data collected by an autonomous ice-based observatory that drifted into the Eurasian Basin between April and November 2010 indicate that the upper ocean was appreciably fresher than in 2007 and 2008. Sea ice and snowmelt over the course of the 2010 drift amounted to an input of less than 0.5 m of liquid freshwater to the ocean (comparable to the freshening by melting estimated for those previous years), while the observed change in upper-ocean salinity over the melt period implies a freshwater gain of about 0.7 m. Results of a wind-driven ocean model corroborate the observations of freshening and suggest that unusually fresh surface waters observed in parts of the Eurasian Basin in 2010 may have been due to the spreading of anomalously fresh water previously residing in the Beaufort Gyre. This flux is likely associated with a 2009 shift in the large-scale atmospheric circulation to a significant reduction in strength of the anticyclonic Beaufort Gyre and the Transpolar Drift Stream. C1 [Timmermans, M-L.] Yale Univ, Dept Geol & Geophys, New Haven, CT 06511 USA. [Proshutinsky, A.; Krishfield, R. A.; Toole, J. M.] Woods Hole Oceanog Inst, Dept Phys Oceanog, Woods Hole, MA 02543 USA. [Perovich, D. K.; Richter-Menge, J. A.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Stanton, T. P.] USN, Dept Oceanog, Postgrad Sch, Monterey, CA 93943 USA. RP Timmermans, ML (reprint author), Yale Univ, Dept Geol & Geophys, 210 Whitney Ave, New Haven, CT 06511 USA. EM mary-louise.timmermans@yale.edu RI Timmermans, Mary-Louise/N-5983-2014 FU National Science Foundation Office of Polar Programs Arctic Sciences Section [ARC-0519899, ARC-0856479, ARC-0806306] FX The instruments used in this study were deployed in collaboration with the North Pole Environmental Observatory (NPEO) from the Russian Barneo ice camps with logistic support provided by Andy Heiberg from the Polar Science Center (University of Washington) and Tom Quinn from CH2M Hill Polar Services. We appreciate the use of CTD data from the Freshwater Switchyard of the Arctic Ocean and the NPEO hydrographic surveys. The Ice-Tethered Profiler data were collected and made available by the Ice-Tethered Profiler Program based at the Woods Hole Oceanographic Institution (http://www.whoi.edu/itp). This work was funded by the National Science Foundation Office of Polar Programs Arctic Sciences Section under awards ARC-0519899, ARC-0856479, and ARC-0806306. Web cam images were provided by NOAA-PMEL. Ocean Data View software was used in this work (http://odv.awi.de/). NR 48 TC 41 Z9 41 U1 1 U2 26 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL 23 PY 2011 VL 116 AR C00D03 DI 10.1029/2011JC006975 PG 17 WC Oceanography SC Oceanography GA 796YP UT WOS:000293089700002 ER PT J AU Rodriguez-Santiago, V Bujanda, AA Stein, BE Pappas, DD AF Rodriguez-Santiago, Victor Bujanda, Andres A. Stein, Benjamin E. Pappas, Daphne D. TI Atmospheric Plasma Processing of Polymers in Helium-Water Vapor Dielectric Barrier Discharges SO PLASMA PROCESSES AND POLYMERS LA English DT Article DE adhesion; dielectric barrier discharge; polymers; surface functionalization; water vapor plasma ID PRESSURE PLASMA; OXYGEN-PLASMA; SURFACE MODIFICATION; POLY(ETHYLENE-TEREPHTHALATE); OXIDATION; FUNCTIONALIZATION; SPECTROSCOPY AB In this study, the surfaces of ultrahigh molecular weight polyethylene (UHMWPE), poly( ethylene terephthalate) (PET), and polytetrafluoroethylene (PTFE) films were treated with a helium-water vapor plasma at atmospheric pressure and room temperature. Surface changes related to hydrophilicity, chemical funtionalization, surface energy, and adhesive strength after plasma treatment were investigated using water contact angle (WCA) measurements, Xray photoelectron spectroscopy (XPS), and mechanical T-peel tests. Results indicate increased surface energy accompanied with enhanced hydrophilicity. WCA decreased by 36, 50, and 16% for UHMWPE, PET, and PTFE, respectively, after only 0.4 s treatment. For UHMWPE, it is shown that the surface functionalization can be tailored depending on the plasma exposure time. Aging studies performed for these three polymers show the stability of the surface groups as indicated by a small increase in WCA values of plasma treated samples which can be attributed to cross-linking of surface and subsurface polymer chains. XPS analysis of the surfaces show increased oxygen content via the formation of polar, hydroxyl-based functional groups. Furthermore, major changes in the polymer structure of PET are observed, possibly due to the opening of the aromatic rings caused by the plasma energetic species. T-peel test results show an 8, 7.5, and 400-fold increase in peel strength for UHMWPE, PET, and PTFE, respectively. Most importantly, it is shown that water-vapor based plasmas can be a promising, "green,'' inexpensive route to promote the surface activation of polymers. C1 [Rodriguez-Santiago, Victor; Bujanda, Andres A.; Stein, Benjamin E.; Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rodriguez-Santiago, V (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM victor.rodriguez31@us.army.mil RI Rodriguez-Santiago, Victor/B-7447-2011; OI Pappas, Daphne/0000-0002-5746-8873; Rodriguez-Santiago, Victor/0000-0002-8389-5414 FU U.S. Army Research Laboratory; U.S. Department of Energy FX We thank Dr. Josh Orlicki and Dr. Andre Williams for fruitful discussions about polymer reactions. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 29 TC 22 Z9 22 U1 3 U2 24 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1612-8850 J9 PLASMA PROCESS POLYM JI Plasma Process. Polym. PD JUL 22 PY 2011 VL 8 IS 7 BP 631 EP 639 DI 10.1002/ppap.201000186 PG 9 WC Physics, Applied; Physics, Fluids & Plasmas; Physics, Condensed Matter; Polymer Science SC Physics; Polymer Science GA 799GH UT WOS:000293273400006 ER PT J AU Spradling, KD Lumley, LA Robison, CL Meyerhoff, JL Dillman, JF AF Spradling, Kimberly D. Lumley, Lucille A. Robison, Christopher L. Meyerhoff, James L. Dillman, James F., III TI Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin SO JOURNAL OF NEUROINFLAMMATION LA English DT Article DE Nerve Agent; Chemical Warfare; Organophosphate; Sarin; Seizure; Neuroinflammation; Cytokine; Chemokine; Microarray; Transcriptomics ID SOMAN-INDUCED SEIZURES; TEMPORAL-LOBE EPILEPSY; RAT-BRAIN; NEUROPATHOLOGY; CYTOKINES; BARRIER; INTERLEUKIN-1; INDUCTION; DAMAGE; EPILEPTOGENESIS AB Background: Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well understood. To help determine these pathways, we previously used microarray analysis to identify gene expression changes in the rat piriform cortex, a region of the rat brain sensitive to nerve agent exposure, over a 24-h time period following sarin-induced seizure. We found significant differences in gene expression profiles and identified secondary responses that potentially lead to brain injury and cell death. To advance our understanding of the molecular mechanisms involved in sarin-induced toxicity, we analyzed gene expression changes in four other areas of the rat brain known to be affected by nerve agent-induced seizure (amygdala, hippocampus, septum, and thalamus). Methods: We compared the transcriptional response of these four brain regions to sarin-induced seizure with the response previously characterized in the piriform cortex. In this study, rats were challenged with 1.0 x LD(50) sarin and subsequently treated with atropine sulfate, 2-pyridine aldoxime methylchloride, and diazepam. The four brain regions were collected at 0.25, 1, 3, 6, and 24 h after seizure onset, and total RNA was processed for microarray analysis. Results: Principal component analysis identified brain region and time following seizure onset as major sources of variability within the dataset. Analysis of variance identified genes significantly changed following sarin-induced seizure, and gene ontology analysis identified biological pathways, functions, and networks of genes significantly affected by sarin-induced seizure over the 24-h time course. Many of the molecular functions and pathways identified as being most significant across all of the brain regions were indicative of an inflammatory response. There were also a number of molecular responses that were unique for each brain region, with the thalamus having the most distinct response to nerve agent-induced seizure. Conclusions: Identifying the molecular mechanisms involved in sarin-induced neurotoxicity in these sensitive brain regions will facilitate the development of novel therapeutics that can potentially provide broad-spectrum protection in five areas of the central nervous system known to be damaged by nerve agent-induced seizure. C1 [Spradling, Kimberly D.; Dillman, James F., III] USAMRICD, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. [Lumley, Lucille A.; Robison, Christopher L.] USAMRICD, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. [Meyerhoff, James L.] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. RP Dillman, JF (reprint author), USAMRICD, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM james.dillman@us.army.mil FU National Institutes of Health-Countermeasures Against Chemical Threats [Y1-OD-9613-01]; National Research Council Research Associate through the NIH FX We thank Dr. Robert Kan and Dr. Erik Johnson for the critical reading of the manuscript. We than Alexandre Katos for assistance with formatting the figures. We also thank Stephen Estes, Kristen Kamberger, Mark Schultz, SSG Bountieng Somsamayvong, and Theresa Ward for their technical assistance, and Chelsea Crum for assistance with microarray data submission. This research was supported by an interagency agreement with the National Institutes of Health-Countermeasures Against Chemical Threats (CounterACT) Research Program to Dr. Tsung-Ming Shih (Agreement Number: Y1-OD-9613-01). The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army or the Department of Defense. The experimental protocol was approved by the Animal Care and Use Committee at USAMRICD and all husbandry procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (NRC, 1996). Dr. Spradling was supported as a National Research Council Research Associate through the NIH CounterACT Research Program. NR 50 TC 10 Z9 10 U1 1 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD JUL 21 PY 2011 VL 8 AR 84 DI 10.1186/1742-2094-8-84 PG 21 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 828OS UT WOS:000295512300001 PM 21777430 ER PT J AU Spradling, KD Lumley, LA Robison, CL Meyerhoff, JL Dillman, JF AF Spradling, Kimberly D. Lumley, Lucille A. Robison, Christopher L. Meyerhoff, James L. Dillman, James F., III TI Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures SO JOURNAL OF NEUROINFLAMMATION LA English DT Article DE Nerve Agent; Chemical Warfare; Organophosphate; Sarin; Piriform Cortex; Seizure; Neuroinflammation; Cytokine; Microarray; Transcriptomics ID SOMAN-INDUCED SEIZURES; GENE-EXPRESSION PROFILES; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; BIS-(2-CHLOROETHYL) SULFIDE; CHOLINE LEVELS; KAINIC ACID; BRAIN; ACETYLCHOLINESTERASE; DAMAGE AB Background: Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasures to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury. Methods: To determine potential therapeutic targets for such treatments, we analyzed gene expression changes in the rat piriform cortex following sarin (O-isopropylmethylphosphonofluoridate)-induced seizure. Male Sprague-Dawley rats were challenged with 1 x LD(50) sarin and subsequently treated with atropine sulfate, 2-pyridine aldoxime methylchloride (2-PAM), and the anticonvulsant diazepam. Control animals received an equivalent volume of vehicle and drug treatments. The piriform cortex, a brain region particularly sensitive to neural damage from sarin-induced seizures, was extracted at 0.25, 1, 3, 6, and 24 h after seizure onset, and total RNA was processed for microarray analysis. Principal component analysis identified sarin-induced seizure occurrence and time point following seizure onset as major sources of variability within the dataset. Based on these variables, the dataset was filtered and analysis of variance was used to determine genes significantly changed in seizing animals at each time point. The calculated p-value and geometric fold change for each probeset identifier were subsequently used for gene ontology analysis to identify canonical pathways, biological functions, and networks of genes significantly affected by sarin-induced seizure over the 24-h time course. Results: A multitude of biological functions and pathways were identified as being significantly altered following sarin-induced seizure. Inflammatory response and signaling pathways associated with inflammation were among the most significantly altered across the five time points examined. Conclusions: This analysis of gene expression changes in the rat brain following sarin-induced seizure and the molecular pathways involved in sarin-induced neurodegeneration will facilitate the identification of potential therapeutic targets for the development of effective neuroprotectants to treat nerve agent exposure. C1 [Spradling, Kimberly D.; Dillman, James F., III] USAMRICD, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. [Lumley, Lucille A.; Robison, Christopher L.] USAMRICD, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. [Meyerhoff, James L.] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. RP Dillman, JF (reprint author), USAMRICD, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM james.dillman@us.army.mil FU National Institutes of Health [Y1-OD-9613-01] FX We thank Dr. John McDonough and Dr. Erik Johnson for the critical reading of the manuscript and Dr. Mark Moffett for his efforts in generating the EEG graphics. We thank Alexandre Katos for assistance with formatting the figures. We also thank Stephen Estes, Kristen Kamberger, Mark Schultz, SSG Bountieng Somsamayvong, and Theresa Ward for their technical assistance, and Chelsea Crum for assistance with microarray data submission. This research was supported by an interagency agreement with the National Institutes of Health- Countermeasures Against Chemical Threats (CounterACT) Research Program to Dr. Tsung-Ming Shih (Agreement Number: Y1-OD-9613-01). The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army or the Department of Defense. The experimental protocol was approved by the Animal Care and Use Committee at USAMRICD and all husbandry procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (NRC, 1996). Dr. Spradling was supported as a National Research Council Research Associate through the NIH CounterACT Research Program. NR 48 TC 6 Z9 6 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD JUL 21 PY 2011 VL 8 AR 83 DI 10.1186/1742-2094-8-83 PG 21 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 816KL UT WOS:000294597800001 PM 21777429 ER PT J AU Carr, R Comer, J Ginsberg, MD Aksimentiev, A AF Carr, Rogan Comer, Jeffrey Ginsberg, Mark D. Aksimentiev, Aleksei TI Microscopic Perspective on the Adsorption Isotherm of a Heterogeneous Surface SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID HYDROPHILIC SURFACES; MOLECULAR-DYNAMICS; WATER; PROTEINS; MODEL; DNA AB Adsorption of dissolved molecules onto solid surfaces can be extremely sensitive to the atomic-scale properties of the solute and surface, causing difficulties for the design of fluidic systems in industrial, medical, and technological applications. In this communication, we show that the Langmuir isotherm for adsorption of a small molecule to a realistic, heterogeneous surface can be predicted from atomic structures of the molecule and surface through molecular dynamics (MD) simulations. We highlight the method by studying the adsorption of dimethyl methylphosphonate (DMMP) to amorphous silica substrates and show that subtle differences in the atomic-scale surface properties can have drastic effects on the Langmuir isotherm. The sensitivity of the method presented is sufficient to permit the optimization of fluidic devices and to determine fundamental design rules for controlling adsorption at the nanoscale. C1 [Carr, Rogan; Comer, Jeffrey; Aksimentiev, Aleksei] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Aksimentiev, Aleksei] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. [Ginsberg, Mark D.] USA, ERDC CERL, Champaign, IL 61826 USA. RP Aksimentiev, A (reprint author), Univ Illinois, Dept Phys, 1110 W Green St, Urbana, IL 61801 USA. EM aksiment@illinois.edu RI Comer, Jeffrey/H-4453-2011; OI Aksimentiev, Aleksei/0000-0002-6042-8442 FU National Science Foundation [DMR-0955959]; Petroleum Research Fund [48352-G6]; National Institutes of Health [P41-RR05969]; U.S. Army Engineer Research and Development Center - Construction Engineering Research Laboratory (ERDC-CERL); TeraGrid [MCA05S028]; Department of Defense at the ERDC Supercomputing Resource Center, Vicksburg, Mississippi FX The authors would like to thank Karin Dahmen and Vincent Hock for their comments on this work. This work was supported by a grant from the National Science Foundation (DMR-0955959), and in part by the Petroleum Research Fund (48352-G6) and National Institutes of Health (P41-RR05969), and through a cooperative research agreement with the U.S. Army Engineer Research and Development Center - Construction Engineering Research Laboratory (ERDC-CERL). The authors gladly acknowledge supercomputer time provided by the TeraGrid through Grant MCA05S028 and through the Department of Defense High Performance Computing Modernization Program at the ERDC Supercomputing Resource Center, Vicksburg, Mississippi. NR 23 TC 12 Z9 13 U1 2 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JUL 21 PY 2011 VL 2 IS 14 BP 1804 EP 1807 DI 10.1021/jz200749d PG 4 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 798GY UT WOS:000293191800030 PM 22611479 ER PT J AU Khedir, KR Kannarpady, GK Ishihara, H Woo, J Trigwell, S Ryerson, C Biris, AS AF Khedir, Khedir R. Kannarpady, Ganesh K. Ishihara, Hidetaka Woo, Justin Trigwell, Steve Ryerson, Charles Biris, Alexandru S. TI Advanced Studies of Water Evaporation Kinetics over Teflon-Coated Tungsten Nanorod Surfaces with Variable Hydrophobicity and Morphology SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID POLYMER SURFACES; CONTACT-ANGLE; SUPERHYDROPHOBIC SURFACES; SESSILE DROPLET; COATINGS; ADHESION AB Here, we present the process of water droplet evaporation over hydrophobic/superhydrophobic tungsten nanorod (WNRs) surfaces with various nanoscale morphologies and porosities. The WNR surfaces were fabricated by varying both Ar pressure and substrate tilting angle in radio-frequency magnetron sputtering by using the glancing angle deposition technique; their characteristics were analyzed by electron/atomic force microscopy and spectroscopy. The variation in the droplets' contact angle, contact line diameter, and central height as a function of time showed that the evaporation process was highly influenced by the nanomorphology of the. substrate. The surface roughness correlating with the wetting regime (Wenzel and/or Cassie) and the subsequent variation in the contact angle hysteresis (CAR) of the surfaces had a significant effect on the duration of each of the three evaporation modes that were identified. A strong agreement for the CAR determined by using two approaches-dynamic method (adding/withdrawing water to/from surfaces) and natural evaporation process-was observed. In addition, these nanoscale rough surfaces have shown no abrupt transition from dewetting (Cassie) regime to wetting (Wenzel) regime, and the surfaces are less vulnerable to the transition in the case of very small-sized water droplets. Such studies could be the foundation for the development of highly tunable surface platform technologies with applications in water or possibly ice mitigation, biology, aerospace. C1 [Khedir, Khedir R.; Kannarpady, Ganesh K.; Ishihara, Hidetaka; Woo, Justin; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Trigwell, Steve] ASRC Aerosp, Appl Sci & Technol, Orlando, FL 32899 USA. [Ryerson, Charles] Ctr US Army Corps Engineers, Terr & Cryospher Sci Branch Cold Reg, Res & Engn Lab Engineer Res & Dev, Hanover, NH 03755 USA. RP Kannarpady, GK (reprint author), Univ Arkansas, Nanotechnol Ctr, 2801 S Univ Ave, Little Rock, AR 72204 USA. EM gkkannarpady@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU U.S. Army [W912HZ-09-02-0008]; Arkansas Science & Technology Authority [08-CAT-03]; Department of Energy [DE-FG36-06GO86072]; National Science Foundation [NSF/EPS-1003970] FX Financial support from the U.S. Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008), the Arkansas Science & Technology Authority (Grant No. 08-CAT-03), the Department of Energy (DE-FG36-06GO86072), and National Science Foundation (NSF/EPS-1003970) is greatly appreciated. The editorial assistance of Dr. Marinelle Ringer is also acknowledged. NR 35 TC 11 Z9 11 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 21 PY 2011 VL 115 IS 28 BP 13804 EP 13812 DI 10.1021/jp203238v PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 794JQ UT WOS:000292892600033 ER PT J AU Lannoo, MJ Petersen, C Lovich, RE Nanjappa, P Phillips, C Mitchell, JC Macallister, I AF Lannoo, Michael J. Petersen, Christopher Lovich, Robert E. Nanjappa, Priya Phillips, Christopher Mitchell, Joseph C. Macallister, Irene TI Do Frogs Get Their Kicks on Route 66? Continental US Transect Reveals Spatial and Temporal Patterns of Batrachochytrium dendrobatidis Infection SO PLOS ONE LA English DT Article ID AMPHIBIAN CHYTRID FUNGUS; POPULATION DECLINES; RANA-CATESBEIANA; RAIN-FOREST; COSTA-RICA; SEASONAL-VARIATION; EMERGING PATHOGEN; AMERICAN BULLFROG; SURVEY PROTOCOL; MASS MORTALITY AB The chytrid fungus Batrachochytrium dendrobatidis (Bd) has been devastating amphibians globally. Two general scenarios have been proposed for the nature and spread of this pathogen: Bd is an epidemic, spreading as a wave and wiping out individuals, populations, and species in its path; and Bd is endemic, widespread throughout many geographic regions on every continent except Antarctica. To explore these hypotheses, we conducted a transcontinental transect of United States Department of Defense (DoD) installations along U. S. Highway 66 from California to central Illinois, and continuing eastward to the Atlantic Seaboard along U. S. Interstate 64 (in sum from Marine Corps Base Camp Pendleton in California to Naval Air Station Oceana in Virginia). We addressed the following questions: 1) Does Bd occur in amphibian populations on protected DoD environments? 2) Is there a temporal pattern to the presence of Bd? 3) Is there a spatial pattern to the presence of Bd? and 4) In these limited human-traffic areas, is Bd acting as an epidemic (i.e., with evidence of recent introduction and/or die-offs due to chytridiomycosis), or as an endemic (present without clinical signs of disease)? Bd was detected on 13 of the 15 bases sampled. Samples from 30 amphibian species were collected (10% of known United States' species); half (15) tested Bd positive. There was a strong temporal (seasonal) component; in total, 78.5% of all positive samples came in the first (spring/early-summer) sampling period. There was also a strong spatial component-the eleven temperate DoD installations had higher prevalences of Bd infection (20.8%) than the four arid (<60 mm annual precipitation) bases (8.5%). These data support the conclusion that Bd is now widespread, and promote the idea that Bd can today be considered endemic across much of North America, extending from coast-to-coast, with the exception of remote pockets of naive populations. C1 [Lannoo, Michael J.] Indiana Univ Sch Med, Terre Haute, IN USA. [Petersen, Christopher] USN, Facil Engn Command Atlantic, Norfolk, VA USA. [Lovich, Robert E.] USN, Facil Engn Command SW, San Diego, CA 92152 USA. [Nanjappa, Priya] Assoc Fish & Wildlife Agcy, Washington, DC USA. [Phillips, Christopher] Univ Illinois, Inst Nat Resource Sustainabil, Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Mitchell, Joseph C.] Mitchell Ecol Res Serv, Gainesville, FL USA. [Macallister, Irene] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL USA. RP Lannoo, MJ (reprint author), Indiana Univ Sch Med, Terre Haute, IN USA. EM mlannoo@iupui.edu FU U.S. Department of Defense [09-426] FX Support for this project came from a U.S. Department of Defense Legacy grant (#09-426; https://www.dodlegacy.org.legacy/index.aspx). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 101 TC 12 Z9 16 U1 4 U2 23 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 21 PY 2011 VL 6 IS 7 AR e22211 DI 10.1371/journal.pone.0022211 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 795FA UT WOS:000292956800032 PM 21811576 ER PT J AU Katz, A Wissink, AM Sankaran, V Meakin, RL Chan, WM AF Katz, Aaron Wissink, Andrew M. Sankaran, Venkateswaran Meakin, Robert L. Chan, William M. TI Application of strand meshes to complex aerodynamic flow fields SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Computational fluid dynamics; Aerodynamics; High-order methods; Adaptive mesh refinement; Mesh generation ID CIRCULAR-CYLINDER; GRID GENERATION AB We explore a new approach for viscous computational fluid dynamics calculations for external aerodynamics around geometrically complex bodies that incorporates nearly automatic mesh generation and efficient flow solution methods. A prismatic-like grid using "strands" is grown a short distance from the body surface to capture the viscous boundary layer, and adaptive Cartesian grids are used throughout the rest of the domain. The approach presents several advantages over established methods: nearly automatic grid generation from triangular or quadrilateral surface tessellations, very low memory overhead, automatic mesh adaptivity for time-dependent problems, and fast and efficient solvers from structured data in both the strand and Cartesian grids. The approach is evaluated for complex geometries and flow fields. We investigate the effects of strand length and strand vector smoothing to understand the effects on computed solutions. Results of three applications using the strand-adaptive Cartesian approach are given, including a NACA wing, isolated V-22 (TRAM) rotor in hover, and the DLR-F6 wing-body transport. The results from these cases show that the strand approach can successfully resolve near-body and off-body features as well as or better than established methods. (C) 2011 Elsevier Inc. All rights reserved. C1 [Katz, Aaron; Chan, William M.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Katz, Aaron; Wissink, Andrew M.; Sankaran, Venkateswaran] USA, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. [Meakin, Robert L.] Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA. RP Katz, A (reprint author), NASA, Ames Res Ctr, M-S 215-1, Moffett Field, CA 94035 USA. EM akatz@merlin.arc.nasa.gov RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 FU Department of Defense High Performance Computing Modernization Office (HPCMO); HPCMO FX Development was performed at the HPC Institute for Advanced Rotorcraft Modeling and Simulation (HIARMS) located at the US Army Aeroflightdynamics Directorate at Moffett Field, CA, which is supported by the Department of Defense High Performance Computing Modernization Office (HPCMO). Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the HPCMO. NR 33 TC 9 Z9 9 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD JUL 20 PY 2011 VL 230 IS 17 BP 6512 EP 6530 DI 10.1016/j.jcp.2011.04.036 PG 19 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 796EO UT WOS:000293034800008 ER PT J AU Day, J Li, J Lie, DYC Bradford, C Lin, JY Jiang, HX AF Day, Jacob Li, J. Lie, D. Y. C. Bradford, Charles Lin, J. Y. Jiang, H. X. TI III-Nitride full-scale high-resolution microdisplays SO APPLIED PHYSICS LETTERS LA English DT Article ID LIGHT-EMITTING-DIODES; GAN; DEVICES AB We report the realization and properties of a high-resolution solid-state self-emissive microdisplay based on III-nitride semiconductor micro-size light emitting diodes (mu LEDs) capable of delivering video graphics images. The luminance level of III-nitride microdisplays is several orders of magnitude higher than those of liquid crystal and organic-LED displays. The pixel emission intensity was almost constant over an operational temperature range from 100 to -100 degrees C. The outstanding performance is a direct attribute of III-nitride semiconductors. An energy efficient active drive scheme is accomplished by hybrid integration between mu LED arrays and Si CMOS (complementary metal-oxide-semiconductor) active matrix integrated circuits. These integrated devices could play important roles in emerging fields such as biophotonics and optogenetics, as well as ultra-portable products such as next generation pico-projectors. (C) 2011 American Institute of Physics. [doi:10.1063/1.3615679] C1 [Day, Jacob; Lie, D. Y. C.; Lin, J. Y.; Jiang, H. X.] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. [Li, J.] III N Technol Inc, Lubbock, TX 79416 USA. [Bradford, Charles] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Lin, JY (reprint author), Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. EM jingyu.lin@ttu.edu; hx.jiang@ttu.edu RI Lin, Jingyu/A-7276-2011; Jiang, Hongxing/F-3635-2011; Li, Jing/B-7828-2015 OI Lin, Jingyu/0000-0003-1705-2635; Jiang, Hongxing/0000-0001-9892-4292; Li, Jing/0000-0003-2880-7933 FU ARMY [W909MY-09-C-0014]; ATT Foundation FX This work is supported by ARMY contract No. W909MY-09-C-0014. We thank Sixuan Jin and Weiping Zhao for their skillful help with lithography and device processing. We gratefully acknowledge useful discussions with Zhaoyang Fan. Lin and Jiang are grateful to the AT&T Foundation for the support of Ed Whitacre and Linda Whitacre Endowed chairs. NR 21 TC 32 Z9 33 U1 5 U2 41 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 18 PY 2011 VL 99 IS 3 AR 031116 DI 10.1063/1.3615679 PG 3 WC Physics, Applied SC Physics GA 804UH UT WOS:000293679000015 ER PT J AU Prokopenko, O Melkov, G Bankowski, E Meitzler, T Tiberkevich, V Slavin, A AF Prokopenko, Oleksandr Melkov, Gennadiy Bankowski, Elena Meitzler, Thomas Tiberkevich, Vasil Slavin, Andrei TI Noise properties of a resonance-type spin-torque microwave detector SO APPLIED PHYSICS LETTERS LA English DT Article AB We analyze performance of a resonance-type spin-torque microwave detector (STMD) in the presence of noise and reveal two distinct regimes of STMD operation. In the high-frequency regime, the minimum detectable microwave power P(min) limited by the low-frequency Johnson-Nyquist noise and the signal-to-noise ratio (SNR) of STMD is proportional to the input microwave power P(RF). In the low-frequency regime, P(min) is limited by the magnetic noise, and the SNR is proportional to root P(RF). The developed formalism can be used for the optimization of the practical noise-handling parameters of a STMD. (C) 2011 American Institute of Physics. [doi :10.1063/1.3612917] C1 [Prokopenko, Oleksandr; Melkov, Gennadiy] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. [Bankowski, Elena; Meitzler, Thomas] USA, TARDEC, Warren, MI 48397 USA. [Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Prokopenko, O (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. EM ovp@univ.kiev.ua RI Tiberkevich, Vasil/A-8697-2008; Meitzler, Thomas/D-1065-2017; OI Tiberkevich, Vasil/0000-0002-8374-2565; Meitzler, Thomas/0000-0002-0730-3958 FU U.S. Army TARDEC, RDECOM; National Science Foundation of the USA [ECCS-1001815, DMR-1015175]; Ministry of Education and Science of Ukraine [M/90-2010]; State Fund for Fundamental Research of Ukraine [UU34/008] FX This work was supported in part by the Contract from the U.S. Army TARDEC, RDECOM, by the grants ECCS-1001815 and DMR-1015175 from the National Science Foundation of the USA, by the Grant No. M/90-2010 from the Ministry of Education and Science of Ukraine, and by the Grant No. UU34/008 from the State Fund for Fundamental Research of Ukraine. NR 10 TC 12 Z9 12 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 18 PY 2011 VL 99 IS 3 AR 032507 DI 10.1063/1.3612917 PG 3 WC Physics, Applied SC Physics GA 804UH UT WOS:000293679000038 ER PT J AU Matyas, GR Alving, CR AF Matyas, Gary R. Alving, Carl R. TI Antigen-specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol-4-phosphate, cholesterol, and lipid A by a liposomal vaccine containing lipid A SO VACCINE LA English DT Article DE Natural antibodies; Polyspecific antibodies; Innate immunity; Antibodies to lipids; Liposomes; Monophosphoryl lipid A ID BINDING B-CELLS; NORMAL HUMAN SERA; MONOCLONAL-ANTIBODY; ANTIPHOSPHOLIPID ANTIBODIES; POLYREACTIVE ANTIBODIES; IMMUNOGLOBULIN-M; SIMULTANEOUSLY BIND; ADJUVANT SYSTEMS; AUTOANTIBODIES; AUTOREACTIVITY AB Natural IgG antibodies (NA) to lipids are ubiquitously distributed in sera of healthy humans and are believed to serve beneficial functions. Although NA to lipids generally exhibit germ line or near germ line binding specificities, the antibodies commonly increase transiently in the acute phases of most, if not all, infectious diseases and may serve as a first line of defense. In order to determine whether similar anti-lipid antibodies can be induced by a vaccine in humans, we examined stored sera obtained from volunteers who had previously received a candidate vaccine to Plasmodium falciparum. The vaccine had consisted of liposomes that contained both the recombinant protein antigen and also contained monophosphoryl lipid A (MPLA) as an adjuvant. All of the pre-immune sera contained NA to one or more of the liposomal lipids in the vaccine: dimyristol phosphatidylcholine (DMPC), dimyristoyl phosphatidylglycerol (DMPG), cholesterol, and MPLA. After initial immunization, followed by a boost, increased levels of IgG antibodies to all of the liposomal lipids, especially DMPG and MPLA, were observed by ELISA. Antibodies to phosphatidylinositol-4-phosphate (PIP) above the normal pre-immune NA to PIP were also observed. Although PIP was not present in the immunizing liposomes, based on the adsorption of anti-PIP antibodies by DMPG the anti-PIP antibodies were thought to represent cross-reacting anti-DMPG antibodies. The immune response was apparently antigen-specific in that NA to unrelated lipids, other than PIP, that were not present in the liposomes, galactosyl ceramide and ganglioside GM1, were not increased by the immunization. We conclude that antibodies to DMPC, DMPG, PIP, cholesterol, and MPLA can be induced in humans by immunization with liposomes containing MPLA. Published by Elsevier Ltd. C1 [Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM calving@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense FX We gratefully acknowledge the assistance of Ms. Divya Bansal and Mr. Anrudth Matha for performing the ELISAs. Although one of the authors (CRA) participated both as a volunteer and investigator in the original trial [38], the previous and present work was blinded with respect to volunteer identity. The research in this study was approved by the Institutional Review Board of the Walter Reed Army Institute of Research. This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. NR 56 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 18 PY 2011 VL 29 IS 32 BP 5137 EP 5144 DI 10.1016/j.vaccine.2011.05.042 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 808OB UT WOS:000293987200008 PM 21624414 ER PT J AU Barouch, DH Kik, SV Weverling, GJ Dilan, R King, SL Maxfield, LF Clark, S Ng'ang'a, D Brandariz, KL Abbink, P Sinangil, F de Bruyn, G Gray, GE Roux, S Bekker, LG Dilraj, A Kibuuka, H Robb, ML Michael, NL Anzala, O Amornkul, PN Gilmour, J Hural, J Buchbinder, SP Seaman, MS Dolin, R Baden, LR Carville, A Mansfield, KG Pau, MG Goudsmit, J AF Barouch, Dan H. Kik, Sandra V. Weverling, Gerrit J. Dilan, Rebecca King, Sharon L. Maxfield, Lori F. Clark, Sarah Ng'ang'a, David Brandariz, Kara L. Abbink, Peter Sinangil, Faruk de Bruyn, Guy Gray, Glenda E. Roux, Surita Bekker, Linda-Gail Dilraj, Athmanundh Kibuuka, Hannah Robb, Merlin L. Michael, Nelson L. Anzala, Omu Amornkul, Pauli N. Gilmour, Jill Hural, John Buchbinder, Susan P. Seaman, Michael S. Dolin, Raphael Baden, Lindsey R. Carville, Angela Mansfield, Keith G. Pau, Maria G. Goudsmit, Jaap TI International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations SO VACCINE LA English DT Article DE Adenovirus; Vector; Vaccine; HIV-1 ID RHESUS-MONKEYS; HIV-1 VACCINE; NEUTRALIZING ANTIBODIES; GENE-TRANSFER; DOUBLE-BLIND; VECTORS; IMMUNITY; IMMUNOGENICITY; TYPE-5; TRIAL AB Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4 X 10(10) vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Barouch, Dan H.; Dilan, Rebecca; King, Sharon L.; Maxfield, Lori F.; Clark, Sarah; Ng'ang'a, David; Brandariz, Kara L.; Abbink, Peter; Seaman, Michael S.; Dolin, Raphael] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA. [Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Kik, Sandra V.; Weverling, Gerrit J.; Pau, Maria G.; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. [Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA. [de Bruyn, Guy; Gray, Glenda E.] Univ Witwatersrand, Johannesburg, South Africa. [Roux, Surita; Bekker, Linda-Gail] Univ Cape Town, ZA-7925 Cape Town, South Africa. [Dilraj, Athmanundh] S African MRC, Durban, South Africa. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Robb, Merlin L.; Michael, Nelson L.] US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD USA. [Anzala, Omu] Univ Nairobi, Nairobi, Kenya. [Amornkul, Pauli N.; Gilmour, Jill] Int AIDS Vaccine Initiat, New York, NY USA. [Gilmour, Jill] Univ London Imperial Coll Sci Technol & Med, London, England. [Hural, John] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Buchbinder, Susan P.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Baden, Lindsey R.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Carville, Angela; Mansfield, Keith G.] New England Primate Res Ctr, Southborough, MA USA. RP Barouch, DH (reprint author), Beth Israel Deaconess Med Ctr, Div Vaccine Res, E CLS 1047,330 Brookline Ave, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu FU U.S. National Institutes of Health [AI066305, AI066924, AI078526]; Bill & Melinda Gates Foundation [38614]; Elizabeth Glaser Pediatric AIDS Foundation; Ragon Institute of MGH, MIT, and Harvard; U.S. Agency for International Development [GPO-A-00-06-00006-00] FX We thank A. Riggs, D. Lynch, A. La Porte, N. Simmons, J. lampietro, F. Stephens, D. Casimiro, M. Robertson, J. Shiver, J. McElrath, B. Farrah, J. Cox, P. Fast, H. Jaspan, G. Stevens, P. Chetty, T. Tarragona, L. Clark, A. Raxworthy-Cooper, M. Price, E. Cormier, K. Higgins, and M. Pensiero for generous advice, assistance, and reagents. We acknowledge support from the U.S. National Institutes of Health (AI066305, AI066924, AI078526), the Bill & Melinda Gates Foundation (#38614), the Elizabeth Glaser Pediatric AIDS Foundation, and the Ragon Institute of MGH, MIT, and Harvard. The IAVI samples were collected with funding from the U.S. Agency for International Development (GPO-A-00-06-00006-00). The MIRA and PIP samples were collected with funding from the Bill & Melinda Gates Foundation. NR 23 TC 89 Z9 90 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 18 PY 2011 VL 29 IS 32 BP 5203 EP 5209 DI 10.1016/j.vaccine.2011.05.025 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 808OB UT WOS:000293987200016 PM 21619905 ER PT J AU Zehnpfennig, J Bahl, G Tomes, M Carmon, T AF Zehnpfennig, John Bahl, Gaurav Tomes, Matthew Carmon, Tal TI Surface optomechanics: calculating optically excited acoustical whispering gallery modes in microspheres SO OPTICS EXPRESS LA English DT Article ID STIMULATED BRILLOUIN-SCATTERING; FIBERS; MICROCAVITIES; GENERATION; CHIP AB Stimulated Brillouin scattering recently allowed experimental excitation of surface acoustic resonances in micro-devices, enabling vibration at rates in the range of 50 MHz to 12 GHz. The experimental availability of such mechanical whispering gallery modes in photonic-MEMS raises questions on their structure and spectral distribution. Here we calculate the form and frequency of such vibrational surface whispering gallery modes, revealing diverse types of surface vibrations including longitudinal, transverse, and Rayleigh-type deformations. We parametrically investigate these various modes by changing their orders in the azimuthal, radial, and polar directions to reveal different vibrational structures including mechanical resonances that are localized near the interface with the environment where they can sense changes in the surroundings. (C)2011 Optical Society of America C1 [Zehnpfennig, John] US Mil Acad, West Point, NY 10996 USA. [Zehnpfennig, John; Bahl, Gaurav; Tomes, Matthew; Carmon, Tal] Univ Michigan, Ann Arbor, MI 48109 USA. RP Zehnpfennig, J (reprint author), US Mil Acad, 646 Swift Rd, West Point, NY 10996 USA. EM z.zehnpfennig@us.army.mil RI Mischo, William/I-1684-2013; Bahl, Gaurav/A-5044-2014 OI Mischo, William/0000-0003-4234-9836; Bahl, Gaurav/0000-0001-7801-2739 NR 43 TC 15 Z9 15 U1 0 U2 18 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 18 PY 2011 VL 19 IS 15 BP 14240 EP 14248 DI 10.1364/OE.19.014240 PG 9 WC Optics SC Optics GA 794EF UT WOS:000292877600057 PM 21934788 ER PT J AU Smith, SJ Friedrichs, CT AF Smith, S. Jarrell Friedrichs, Carl T. TI Size and settling velocities of cohesive flocs and suspended sediment aggregates in a trailing suction hopper dredge plume SO CONTINENTAL SHELF RESEARCH LA English DT Article DE Dredging; Settling rate; Flocculation; Aggregates; Image processing ID IN-SITU; PARTICLE-SIZE; VIDEO SYSTEM; DENSITY; FLOCCULATION; ESTUARIES; CAMERA; CALIFORNIA; TURBULENCE; LISST-100 AB A field experiment was conducted to quantify settling velocities, aggregate states, and flocculation within a hopper dredge plume. Particular interest was in determining the abundance of dense, bed aggregates suspended from the consolidated bed during dredging. A suspended sediment plume from the hopper dredge Essayons was sampled for a period of 90 min after dredging. Settling velocities and suspended particle sizes were quantified through sampling with the Particle Imaging Camera System (PICS) and automated image processing routines. The sediment plume was identified and a profiling instrumentation frame was positioned within the plume using Acoustic Doppler Current Profiler (ADCP) backscatter. Results indicated that suspended bed aggregates (defined by densities of 1200-1800 kg m(-3)) represented 0.2-0.5 of total suspended mass, and flocs (densities < 1200 kg m(-3)) represented 0.5-0.8 of total suspended mass. The peak diameter of bed aggregates and flocs occurred near 90 and 200 mu m, respectively, corresponding to peak settling velocities of about 1 mm s(-1) in each case. Floc settling velocities increased with particle size d(1.1), while bed aggregate settling velocity increased like d(1.3). Published by Elsevier Ltd. C1 [Smith, S. Jarrell] USA, Engn Res & Dev Ctr, Vicksburg, MS USA. [Friedrichs, Carl T.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA. RP Smith, SJ (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM Jarrell.Smith@usace.army.mil; cfried@vims.edu OI Friedrichs, Carl/0000-0002-1810-900X FU National Science Foundation Division of Ocean Sciences [OCE-0536572]; Office, Chief of Engineers, US Army Corps of Engineers FX The authors gratefully acknowledge the contributions of the San Francisco District, US Army Corps of Engineers for providing the services of the Grizzly, captain, and crew for this field experiment. Captain Bill Brazil and crew (Marty Plisch and Chuck Hadley) provided expert and tireless assistance in piloting the Grizzly and positioning the profiling frame. We also thank Grace Cartwright of the Virginia Institute of Marine Science for her assistance in providing and operating the profiling frame used in this study. The research presented in this paper was conducted under the Dredging Operations and Environmental Research (DOER) program, Dredged Material Management Focus Area at the US Army Engineer Research and Development Center. DOER Program Manager is Dr. Todd Bridges. Additional support for Friedrichs' participation in this study was provided by the National Science Foundation Division of Ocean Sciences Grant OCE-0536572. Permission to publish this paper was granted by the Office, Chief of Engineers, US Army Corps of Engineers. This paper is contribution no. 3068 of the Virginia Institute of Marine Science, College of William and Mary. NR 57 TC 26 Z9 27 U1 2 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-4343 J9 CONT SHELF RES JI Cont. Shelf Res. PD JUL 15 PY 2011 VL 31 IS 10 SU S SI SI BP S50 EP S63 DI 10.1016/j.csr.2010.04.002 PG 14 WC Oceanography SC Oceanography GA 799XL UT WOS:000293319700006 ER PT J AU Morrill, JC Peters, CJ AF Morrill, John C. Peters, C. J. TI Protection of MP-12-Vaccinated Rhesus Macaques Against Parenteral and Aerosol Challenge With Virulent Rift Valley Fever Virus SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID VACCINE; MONKEYS; EGYPT; IMMUNOGENICITY; EPIDEMIC; PATHOGENICITY; ANTIBODIES; HUMANS; SAFETY AB To test safety and efficacy of the Rift Valley fever MP-12 (RVF MP-12) vaccine, 9 healthy adult Rhesus macaques, weighing 5-10 kg, were inoculated intramuscularly with 6 x 10(3) plaque forming units (PFUs) of MP-12 vaccine. The monkeys developed neutralizing antibody responses with no adverse effects other than a transient, low-titer viremia in 3 monkeys. Four vaccinated animals challenged intravenously with 3 x 10(6) PFUs of virulent Rift Valley fever virus strain ZH-501 (RVFV ZH-501) at 126 days after vaccination were protected against infection. The remaining 5 vaccinated monkeys along with 2 monkeys that had been vaccinated 6 years prior were completely protected against a small particle aerosol challenge of 5 x 10(5) PFUs of RVFV ZH-501. The mutagen-attenuated RVF MP-12 vaccine was determined to be protective against intravenous and aerosol challenge with virulent RVFV in these macaques, which suggests further development as a vaccine for humans is warranted. C1 [Morrill, John C.; Peters, C. J.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Morrill, JC (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, 301 Univ Blvd,Room 4-142B MRB, Galveston, TX 77555 USA. EM jcmorril@utmb.edu FU Department of Defense FX This work was supported by the Department of Defense (intramural research funding). NR 35 TC 25 Z9 25 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2011 VL 204 IS 2 BP 229 EP 236 DI 10.1093/infdis/jir249 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 790AZ UT WOS:000292562200011 PM 21673033 ER PT J AU Seay, JF Van Emmerik, REA Hamill, J AF Seay, Joseph F. Van Emmerik, Richard E. A. Hamill, Joseph TI Influence of Low Back Pain Status on Pelvis-Trunk Coordination During Walking and Running SO SPINE LA English DT Article DE back pain; running; walking; biomechanics; vector coding; coordination; angle-angle plots; resolved back pain ID LUMBAR SPINE; KINEMATICS; HISTORY AB Study Design. Two-way repeated-measures analysis of variance. Objective. To assess pelvis and trunk three-dimensional segmental excursions and coordination differences during walking and running between runners with low back pain (LBP), runners with resolved LBP, and a control group with no history of LBP. Summary of Background Data. Studies have documented differences in pelvis and trunk coordination between those with moderate to severe LBP during walking. Few studies document pelvis and trunk mechanics in those with low to moderate LBP and individuals who recover from LBP even though these individuals comprise 80% of LBP cases and are at increased risk for re-injury. Methods. Recreational runners walked and ran on a treadmill at speeds including 0.8 to 3.8 m/s at 0.5 m/s increments. Pelvis and trunk kinematic data were collected during the last 20 s of each stage. Coordination analysis quantified the portion of gait cycle each group spent in trunk only motion, pelvis-only motion, in-phase, and antiphase relationships. Results. During walking, the LBP group spent more of the gait cycle in-phase in the frontal plane (P = 0.030). During running, the LBP group showed greater pelvis axial rotation than the control group (P = 0.014) and spent more of the gait cycle in-phase in the transverse plane (P = 0.019). Also during running, the LBP (P = 0.035) and the resolved LBP (P = 0.037) groups demonstrated reduced antiphase coordination compared to controls. Conclusion. Coordination analysis demonstrates a reduction in relative motion between the pelvis and trunk despite low disability levels in our LBP group and no pain in our group with a history of LBP. C1 [Seay, Joseph F.; Van Emmerik, Richard E. A.; Hamill, Joseph] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. RP Seay, JF (reprint author), USA, Military Performance Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM joseph.seay@us.army.mil FU International Society of Biomechanics FX Supported by an International Society of Biomechanics matching dissertation grant (2006). NR 21 TC 27 Z9 27 U1 6 U2 27 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JUL 15 PY 2011 VL 36 IS 16 BP E1070 EP E1079 DI 10.1097/BRS.0b013e3182015f7c PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 788MY UT WOS:000292450300003 PM 21304421 ER PT J AU Hjelkrem, M Stauch, C Shaw, J Harrison, SA AF Hjelkrem, M. Stauch, C. Shaw, J. Harrison, S. A. TI Validation of the non-alcoholic fatty liver disease activity score SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Article AB Background The non-alcoholic fatty liver disease (NAFLD) activity score (NAS) is a scoring system designed by the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network (CRN) to encompass the spectrum of NAFLD and evaluate histological changes. However, the NAS and the correlation between the NAS and a diagnosis of NASH have not been validated outside the NASH CRN. Aim To validate the NAS outside the NASH CRN. Methods This study retrospectively examined liver biopsies from adults with NAFLD or steatohepatitis obtained from January 2003 to May 2010. Biopsy specimens were evaluated twice in a blinded manner by a single hepatopathologist, once to determine a diagnosis (steatohepatitis or steatosis/not-steatohepatitis), and a second time to determine the NAS. Results A total of 386 liver biopsies were evaluated. Mean age of patients at time of biopsy was 49.9 +/- 10.2 years. NASH was found in 51% of the patients. For NAS >= 5 as a diagnosis of steatohepatitis and NAS <5 for not-steatohepatitis, the sensitivity was 57%, specificity: 95%, negative predictive value (NPV): 68% and positive predictive value (PPV): 93%. Lowering the NAS to >= 4 as a diagnosis of steatohepatitis increased the sensitivity to 85% with a decrease in specificity to 81%; NPV: 84%, PPV: 82% and Cohen's kappa 0.658. Conclusions The NAFLD activity score is a valid scoring system encompassing the spectrum of NAFLD with an excellent level of agreement between the histological diagnosis and the NAFLD activity score. A NAFLD activity score >= 4 has optimal sensitivity and specificity for predicting steatohepatitis, and is the recommended value for admission into an interventional trial for NASH. C1 [Hjelkrem, M.; Harrison, S. A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. [Stauch, C.] Wilford Hall USAF Med Ctr, Dept Med, San Antonio, TX USA. [Shaw, J.] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil FU Rottapharm; Mochida Pharmaceuticals FX Declaration of personal interests: S. A. Harrison has served as an advisory board member for Amylin Pharmaceuticals. He has received research funding from Rottapharm and Mochida Pharmaceuticals. Declaration of funding interests: None. NR 11 TC 22 Z9 23 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-2813 J9 ALIMENT PHARM THER JI Aliment. Pharmacol. Ther. PD JUL 15 PY 2011 VL 34 IS 2 BP 214 EP 218 DI 10.1111/j.1365-2036.2011.04695.x PG 5 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 784JD UT WOS:000292152300010 PM 21585409 ER PT J AU Hurst, FP Belur, P Nee, R Agodoa, LY Patel, P Abbott, KC Jindal, RM AF Hurst, Frank P. Belur, Pallavi Nee, Robert Agodoa, Lawrence Y. Patel, Purav Abbott, Kevin C. Jindal, Rahul M. TI Poor Outcomes Associated With Neutropenia After Kidney Transplantation: Analysis of United States Renal Data System SO TRANSPLANTATION LA English DT Article DE Neutropenia after kidney transplantation; Granulocyte colony-stimulating factors; United States Renal Data System ID MYCOPHENOLATE-MOFETIL; ALLOGRAFT RECIPIENTS; RISK-FACTORS; LEUKOPENIA; THROMBOCYTOPENIA; MANAGEMENT; THERAPY; DISEASE AB Background. Posttransplant neutropenia (PTN) is relatively common after kidney transplantation, and may result in a reduction of immunosuppression, which may precipitate acute rejection. Granulocyte colony-stimulating factors (GCSF) have been used to treat PTN, although outcomes associated with use of this medication in this population are unknown. Methods. In a retrospective cohort of 41,705 adult Medicare primary patients transplanted from January 2001 to June 2006, we assessed Medicare claims for neutropenia, leukopenia, and GCSF use, respectively. Outcomes included allograft loss and death. Results. There were 6043 (14.5%) patients with claims for PTN. Factors associated with PTN included female gender, Caucasian ethnicity, ischemic heart disease, donor cytomegalovirus positive, deceased donor, expanded donor criteria, delayed graft function, elevated panel reactive antibody, higher human leukocyte antigen mismatch, and later year of transplant. Thymoglobulin induction, tacrolimus, and mycophenolate mofetil were also associated. PTN was less frequent among patients with congestive heart failure, recipient cytomegalovirus positive, and interleukin-2 induction. PTN was associated with increased risk of allograft loss (adjusted hazard ratio, 1.59; 95% confidence interval, 1.43-1.76; P<0.001) and death (adjusted hazard ratio, 1.74; 95% confidence interval, 1.59-1.90; P<0.001). Of the 6043 patients with PTN, 740 (12.2%) received GCSF. Patients who received GCSF had a lower risk of death on unadjusted analysis, but this only trended towards significance after adjustment. Conclusions. Neutropenia after renal transplantation is common and is associated with an increased risk of allograft loss and death. GCSF was used in 12% of cases and did not increase risk of allograft loss. Strategies to avoid PTN and greater use of GCSF may be indicated to prevent graft loss and death. C1 [Jindal, Rahul M.] Walter Reed AMC, Div Organ Transplant, Washington, DC USA. [Hurst, Frank P.; Belur, Pallavi; Nee, Robert; Abbott, Kevin C.] Walter Reed Army Med Ctr, Div Nephrol, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. [Patel, Purav] Med Univ Lublin, Lublin, Poland. [Jindal, Rahul M.] George Washington Univ, Dept Med, Washington, DC USA. RP Jindal, RM (reprint author), Walter Reed AMC, Div Organ Transplant, Washington, DC USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 24 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD JUL 15 PY 2011 VL 92 IS 1 BP 36 EP 40 DI 10.1097/TP.0b013e31821c1e70 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 780JY UT WOS:000291853300009 PM 21512429 ER PT J AU Liu, XJ Wang, XH Li, QG Kozar, MP Melendez, V O'Neil, MT Lin, AJ AF Liu, Xianjun Wang, Xihong Li, Qigui Kozar, Michael P. Melendez, Victor O'Neil, Michael T. Lin, Ai J. TI Synthesis and Antimalarial Activity of 2-Guanidino-4-oxoimidazoline Derivatives SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TROPHOZOITE-INDUCED INFECTIONS; PLASMODIUM-FALCIPARUM MALARIA; IMIDAZOLIDINEDIONE DERIVATIVES; TAFENOQUINE; PRIMAQUINE; MEFLOQUINE; CYNOMOLGI; INVITRO; EFFICACY; MONKEYS AB A series of 2-guanidino-4-oxoimidazoline (deoxo-IZ) derivatives was prepared and showed potent antimalarial activities in rodent and Rhesus models. Compound 8e, the most potent analogues of this series, is the first non-8-aminoqinoline antimalarial that demonstrated radical curative activity in non-human primate by Cl oral route and showed causal prophylactic activity comparable to that of the commonly used clinical drugs in Rhesus monkeys infected with sporozoites of Plasmodium cynomolgi. The metabolic stability and metabolites profile indicated that the new deoxo-IZ derivatives (8) may act as prodrugs of the corresponding IZ (1 and 2) derivatives. C1 [Liu, Xianjun; Wang, Xihong; Li, Qigui; Kozar, Michael P.; Melendez, Victor; O'Neil, Michael T.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ai.lin@us.army.mil FU Military Infections Diseases Research Program [A40191_09_WR]; U.S. Army Medical Research and Material Command, Department of Defense [PR054609]; Medicines for Malaria Venture, Geneva, Switzerland [MMV 04/0013] FX This research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and to experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. This research is supported in part by funding from Military Infections Diseases Research Program (Grant A40191_09_WR), U.S. Army Medical Research and Material Command, Department of Defense, U.S., Peer Reviewed Medical Research Program (PRMRP) (Grant PR054609), and Medicines for Malaria Venture (MMV 04/0013), Geneva, Switzerland. NR 35 TC 14 Z9 14 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 14 PY 2011 VL 54 IS 13 BP 4523 EP 4535 DI 10.1021/jm200111g PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 788YF UT WOS:000292479600016 PM 21627120 ER PT J AU Pootong, P Serichantalergs, O Bodhidatta, L Poly, F Guerry, P Mason, CJ AF Pootong, Piyarat Serichantalergs, Oralak Bodhidatta, Ladaporn Poly, Frederic Guerry, Patricia Mason, Carl J. TI Distribution of flagella secreted protein and integral membrane protein among Campylobacter jejuni isolated from Thailand SO GUT PATHOGENS LA English DT Article ID GENOME SEQUENCE; HOST-CELLS; INVASION; APPARATUS AB Background: Campylobacter jejuni, a gram-negative bacterium, is a frequent cause of gastrointestinal food-borne illness in humans throughout the world. There are several reports that the virulence of C. jejuni might be modulated by non-flagellar proteins that are secreted through the filament. Recently, FspA (Flagella secreted proteins) have been described. Two alleles of fspA (fspA1 and fspA2) based on sequence analysis were previously reported and only the fspA2 allele was found in Thai isolates. The aim of this study is to analyze the deduced amino acid sequences fspA and the adjacent putative integral membrane protein from 103 Thai C. jejuni isolates. Results: A total of 103 representative C. jejuni isolates were amplified by PCR for the fspA gene and the adjacent integral membrane protein gene. Two PCR product sizes were amplified using the same primers, an approximately 1600-bp PCR product from 19 strains that contained fspA and integral membrane protein genes and an approximately 800-bp PCR product from 84 strains that contained only the fspA gene. DNA sequencing was performed on the amplified products. The deduced amino acid sequences of both genes were analyzed separately using CLC Free Workbench 4 software. The analysis revealed three groups of FspA. Only FspA group 1 sequences (19/103) (corresponding to fspA1) consisting of 5 subgroups were associated with the adjacent gene encoding the integral membrane protein. FspA group 2 was the largest group (67/103) consisting of 9 subgroups. FspA group 2p (17/103) consisting of 7 subgroups was found to contain stop codons at a position before the terminal 142 position. Conclusions: This study reveals greater heterogeneity of FspA (group 1, 2 and 2p) among Thai C. jejuni isolates than previously reported. Furthermore, the subgroups of FspA groups 1 were associated with groups of integral membrane protein. The significance of these different FspA variants to virulence requires further study. C1 [Pootong, Piyarat; Serichantalergs, Oralak; Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Enter Dis Dept, Bangkok 10400, Thailand. [Poly, Frederic; Guerry, Patricia] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. RP Pootong, P (reprint author), Armed Forces Res Inst Med Sci, Enter Dis Dept, Bangkok 10400, Thailand. EM piyaratp@afrims.org RI Guerry, Patricia/A-8024-2011; OI MASON, CARL/0000-0002-3676-2811 FU Walter Reed Army Institute of Research, Washington, DC, USA FX All study projects described here were financially supported by the Military Infectious Diseases Research Program, Walter Reed Army Institute of Research, Washington, DC, USA. We would like to thank Apichai Srijan, Department of Enteric Diseases at the Armed Forces Research Institute of Medical Sciences (AFRIMS), for his kind provision of C. jejuni strains. The views expressed in this article are those of the author and do not reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government. NR 17 TC 0 Z9 0 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1757-4749 J9 GUT PATHOG JI Gut Pathogens PD JUL 12 PY 2011 VL 3 AR 11 DI 10.1186/1757-4749-3-11 PG 7 WC Gastroenterology & Hepatology; Microbiology SC Gastroenterology & Hepatology; Microbiology GA 879OK UT WOS:000299339900001 PM 21745410 ER PT J AU Lumsden, JM Schwenk, RJ Rein, LE Moris, P Janssens, M Ofori-Anyinam, O Cohen, J Kester, KE Heppner, DG Krzych, U AF Lumsden, Joanne M. Schwenk, Robert J. Rein, Lisa E. Moris, Philippe Janssens, Michel Ofori-Anyinam, Opokua Cohen, Joe Kester, Kent E. Heppner, D. Gray Krzych, Urszula TI Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-alpha Producing Effector and Central Memory CD4(+) T Cells SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM; MALARIA VACCINE; DOUBLE-BLIND; IFN-GAMMA; LYMPHOCYTES; PROTEIN; EFFICACY; SAFETY; PHASE; TRIAL AB A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The frequency of Plasmodium falciparum circumsporozoite protein (CSP)-specific CD4(+) T cells was significantly higher in protected subjects as compared to non-protected subjects. Intrigued by these unique vaccine-related correlates of protection, in the present study we asked whether RTS,S also induced effector/effector memory (T-E/EM) and/or central memory (T-CM) CD4(+) T cells and whether one or both of these sub-populations is the primary source of cytokine production. We showed for the first time that PBMC from malaria-non-exposed RTS,S-immunized subjects contain both T-E/EM and T-CM cells that generate strong IL-2 responses following re-stimulation in vitro with CSP peptides. Moreover, both the frequencies and the total numbers of IL-2-producing CD4(+) T-E/EM cells and of CD4(+) T-CM cells from protected subjects were significantly higher than those from non-protected subjects. We also demonstrated for the first time that there is a strong association between the frequency of CSP peptide-reactive CD4(+) T cells producing IL-2 and the titers of CSP-specific antibodies in the same individual, suggesting that IL-2 may be acting as a growth factor for follicular Th cells and/or B cells. The frequencies of CSP peptide-reactive, TNF-alpha-producing CD4(+) T-E/EM cells and of CD4(+) T-E/EM cells secreting both IL-2 and TNF-alpha were also shown to be higher in protected vs. non-protected individuals. We have, therefore, demonstrated that in addition to TNF-alpha, IL-2 is also a significant contributing factor to RTS,S/AS vaccine induced immunity and that both T-E/EM and T-CM cells are major producers of IL-2. C1 [Lumsden, Joanne M.; Schwenk, Robert J.; Rein, Lisa E.; Kester, Kent E.; Heppner, D. Gray; Krzych, Urszula] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Moris, Philippe; Janssens, Michel; Ofori-Anyinam, Opokua; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. RP Lumsden, JM (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. EM Urszula.Krzych@amedd.army.mil FU United States Army Medical Materiel Development Activity; Military Infectious Diseases Research Program (Fort Detrick, Maryland; GlaxoSmithKline Biologicals (Rixensart, Belgium) FX The project was funded by the United States Army Medical Materiel Development Activity, the Military Infectious Diseases Research Program (Fort Detrick, Maryland) and GlaxoSmithKline Biologicals (Rixensart, Belgium). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 33 Z9 33 U1 2 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 11 PY 2011 VL 6 IS 7 AR e20775 DI 10.1371/journal.pone.0020775 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 791QY UT WOS:000292680900002 PM 21779319 ER PT J AU Kamkar, SJ Wissink, AM Sankaran, V Jameson, A AF Kamkar, S. J. Wissink, A. M. Sankaran, V. Jameson, A. TI Feature-driven Cartesian adaptive mesh refinement for vortex-dominated flows SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Feature detection; Adaptive mesh refinement; Vortex-dominated flows; Multi-solver strategy ID CO-ROTATING VORTICES; CLASSIFICATION; EQUATIONS AB We develop locally normalized feature-detection methods to guide the adaptive mesh refinement (AMR) process for Cartesian grid systems to improve the resolution of vortical features in aerodynamic wakes. The methods include: the Q-criterion [1], the lambda(2) method [2], the lambda(ci) method [3], and the lambda(+) method [4]. Specific attention is given to automate the feature identification process by applying a local normalization based upon the shear-strain rate so that they can be applied to a wide range of flow-fields without the need for user intervention. To validate the methods, we assess tagging efficiency and accuracy using a series of static vortex-dominated flow-fields, and use the methods to drive the AMR process for several theoretical and practical simulations. We demonstrate that the adaptive solutions provide comparable accuracy to solutions obtained on uniformly refined meshes at a fraction of the computational cost. Overall, the normalized feature detection methods are shown to be effective in driving the AMR process in an automated and efficient manner. (C) 2011 Elsevier Inc. All rights reserved. C1 [Kamkar, S. J.; Jameson, A.] Stanford Univ, Dept Aeronaut, Palo Alto, CA 94305 USA. [Wissink, A. M.; Sankaran, V.] USA, Aeroflightdynam Directorate, Ames Res Ctr, Moffett Field, CA 94035 USA. RP Kamkar, SJ (reprint author), Stanford Univ, Dept Aeronaut, Durand Bldg, Palo Alto, CA 94305 USA. EM skamkar@stanford.edu; andrew.m.wissink@us.army.mil; vsankaran@merlin.arc.nasa.gov; jameson@baboon.stanford.edu FU NASA [1125897-1-RAJJN]; U.S. Department of Defense HPC Modernization Program Office FX The first author and Prof. Jameson have been supported by the joint NASA-Stanford fellowship program (Grant # 1125897-1-RAJJN). Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the U.S. Department of Defense HPC Modernization Program Office. Development was performed at the HPC Institute for Advanced Rotorcraft Modeling and Simulation (HI-ARMS) located at the US Army Aeroflightdynamics Directorate at Moffett Field, CA. The authors gratefully acknowledge the contributions to this work by Prof. Jay Sitaraman and Prof. Dimitri Mavriplis at the University of Wyoming and Dr. Thomas Pulliam at NASA Ames Research Center. NR 36 TC 15 Z9 17 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD JUL 10 PY 2011 VL 230 IS 16 BP 6271 EP 6298 DI 10.1016/j.jcp.2011.04.024 PG 28 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 787GY UT WOS:000292365800005 ER PT J AU Poda, AR Bednar, AJ Kennedy, AJ Harmon, A Hull, M Mitrano, DM Ranville, JF Steevens, J AF Poda, A. R. Bednar, A. J. Kennedy, A. J. Harmon, A. Hull, M. Mitrano, D. M. Ranville, J. F. Steevens, J. TI Characterization of silver nanoparticles using flow-field flow fractionation interfaced to inductively coupled plasma mass spectrometry SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Nanoparticle characterization; FFF; ICP-MS; Comparison techniques; Natural matrices ID ELECTRON-MICROSCOPY; MEMBRANE FILTRATION; PARTICLE-SIZE; POROUS-MEDIA; NANOMATERIALS; SPECTROSCOPY; WATER; RISK AB The ability to detect and identify the physiochemical form of contaminants in the environment is important for degradation, fate and transport, and toxicity studies. This is particularly true of nanomaterials that exist as discrete particles rather than dissolved or sorbed contaminant molecules in the environment. Nanoparticles will tend to agglomerate or dissolve, based on solution chemistry, which will drastically affect their environmental properties. The current study investigates the use of field flow fractionation (FFF) interfaced to inductively coupled plasma-mass spectrometry (ICP-MS) as a sensitive and selective method for detection and characterization of silver nanoparticles. Transmission electron microscopy (TEM) is used to verify the morphology and primary particle size and size distribution of precisely engineered silver nanoparticles. Subsequently, the hydrodynamic size measurements by FFF are compared to dynamic light scattering (DLS) to verify the accuracy of the size determination. Additionally, the sensitivity of the ICP-MS detector is demonstrated by fractionation of mu g/L concentrations of mixed silver nanoparticle standards. The technique has been applied to nanoparticle suspensions prior to use in toxicity studies, and post-exposure biological tissue analysis. Silver nanoparticles extracted from tissues of the sediment-dwelling, freshwater oligochaete Lumbriculus variegatus increased in size from approximately 31-46 nm, indicating a significant change in the nanoparticle characteristics during exposure. Published by Elsevier B.V. C1 [Poda, A. R.; Bednar, A. J.; Kennedy, A. J.; Harmon, A.; Steevens, J.] USA, Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Hull, M.] NanoSafe Inc, Blacksburg, VA 24060 USA. [Hull, M.] Virginia Tech, Dept Civil & Environm Engn, ICTAS, Int Ctr Environm Implicat Nanotechnol ICEINT, Blacksburg, VA USA. [Mitrano, D. M.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. RP Poda, AR (reprint author), USA, Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Aimee.R.Poda@usace.army.mil RI Ranville, James/H-1428-2011; Hull, Matt/F-4942-2012; Poda, Aimee/K-1905-2012; Liu, Yifei/L-7828-2014 OI ranville, james/0000-0002-4347-4885; Liu, Yifei/0000-0002-1087-9827 NR 35 TC 92 Z9 94 U1 6 U2 107 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD JUL 8 PY 2011 VL 1218 IS 27 SI SI BP 4219 EP 4225 DI 10.1016/j.chroma.2010.12.076 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 788FX UT WOS:000292431900017 PM 21247580 ER PT J AU Mrozek, RA Cole, PJ Otim, KJ Shull, KR Lenhart, JL AF Mrozek, Randy A. Cole, Phillip J. Otim, Kathryn J. Shull, Kenneth R. Lenhart, Joseph L. TI Influence of solvent size on the mechanical properties and rheology of polydimethylsiloxane-based polymeric gels SO POLYMER LA English DT Article DE Gel; Toughness; Solvent molecular weight ID MODEL POLY(DIMETHYLSILOXANE) NETWORKS; NANOCOMPOSITE HYDROGELS; VISCOELASTIC PROPERTIES; MOLECULAR-WEIGHT; PENDANT CHAINS; MONTE-CARLO; MODULUS; BEHAVIOR; ENTANGLEMENT; PERFORMANCE AB Soft polymeric gels have utility in a broad range of medical, industrial, and military applications, which has led to an extensive research investment over the past several decades. While most gel research exploits a cross-linked polymer network swollen with small molecule solvents, this article systematically investigates the impact of the solvent molecular weight on the resulting gel mechanical properties. The model polymer gel was composed of a chemically cross-linked polydimethylsiloxane (PDMS) network loaded with a non-reactive PDMS solvent. In addition to investigating the impact of solvent loading, the solvent molecular weight was varied from 423,000 g/mol to 1250 g/mol, broadly spanning the molecular weight of entanglement for PDMS (MW(ENT) similar to 29,000 g/mol). The gels exhibited a strong frequency dependent mechanical response when the solvent molecular weight >MW(ENT). In addition, scaling factors of shear storage modulus versus solvent loading displayed a distinct decrease from the theoretical value for networks formed in a theta solvent of 2.3 with increasing measurement frequency and solvent molecular weight. The frequency dependent shear storage modulus could be shifted by the ratio of solvent molecular weights to the 3.4 power to form a master curve at a particular solvent loading indicating that mobility of entangled solvent plays a critical role for the mechanical response. In addition, the incorporation of entangled solvent can increase the toughness of the PDMS gels. Published by Elsevier Ltd. C1 [Mrozek, Randy A.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen, MD 21005 USA. [Mrozek, Randy A.; Cole, Phillip J.; Lenhart, Joseph L.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Cole, Phillip J.] Northrop Grumman A&AS, Arlington, VA 22209 USA. [Otim, Kathryn J.; Shull, Kenneth R.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. RP Mrozek, RA (reprint author), USA, Res Lab, Aberdeen, MD 21005 USA. EM randy.mrozek@us.army.mil; joseph.lenhart1@us.army.mil RI Shull, Kenneth/B-7536-2009 NR 50 TC 21 Z9 21 U1 4 U2 30 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD JUL 7 PY 2011 VL 52 IS 15 BP 3422 EP 3430 DI 10.1016/j.polymer.2011.05.021 PG 9 WC Polymer Science SC Polymer Science GA 789RF UT WOS:000292533300022 ER PT J AU Stany, MP Vathipadiekal, V Ozbun, L Stone, RL Mok, SC Xue, H Kagami, T Wang, YW McAlpine, JN Bowtell, D Gout, PW Miller, DM Gilks, CB Huntsman, DG Ellard, SL Wang, YZ Vivas-Mejia, P Lopez-Berestein, G Sood, AK Birrer, MJ AF Stany, Michael P. Vathipadiekal, Vinod Ozbun, Laurent Stone, Rebecca L. Mok, Samuel C. Xue, Hui Kagami, Takashi Wang, Yuwei McAlpine, Jessica N. Bowtell, David Gout, Peter W. Miller, Dianne M. Gilks, C. Blake Huntsman, David G. Ellard, Susan L. Wang, Yu-Zhuo Vivas-Mejia, Pablo Lopez-Berestein, Gabriel Sood, Anil K. Birrer, Michael J. TI Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers SO PLOS ONE LA English DT Article ID ENDOTHELIAL GROWTH-FACTOR; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; INTERFERING RNA DELIVERY; IN-VIVO; FACTOR EXPRESSION; GENE-EXPRESSION; ANTITUMOR-ACTIVITY; TYROSINE KINASE; FACTOR RECEPTOR; CARCINOMA AB Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology. In vivo validations carried out using an orthotopic mouse model and liposomal encapsulated siRNA. Patient-derived clear cell and serous ovarian tumors were grafted under the renal capsule of NOD-SCID mice to evaluate the therapeutic potential of the identified pathway. We identified major activated pathways in clear cells involving in hypoxic cell growth, angiogenesis, and glucose metabolism not seen in other histotypes. Knockdown of key genes in these pathways sensitized clear cell ovarian cancer cell lines to hypoxia/glucose deprivation. In vivo experiments using patient derived tumors demonstrate that clear cell tumors are exquisitely sensitive to antiangiogenesis therapy (i.e. sunitinib) compared with serous tumors. We generated a histotype specific, gene signature associated with clear cell ovarian cancer which identifies important activated pathways critical for their clinicopathologic characteristics. These results provide a rational basis for a radically different treatment for ovarian clear cell patients. C1 [Stany, Michael P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Vathipadiekal, Vinod; Birrer, Michael J.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Vathipadiekal, Vinod; Birrer, Michael J.] Harvard Univ, Sch Med, Boston, MA USA. [Ozbun, Laurent] NCI, Cell & Canc Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Stone, Rebecca L.; Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. [Mok, Samuel C.] Harvard Univ, Brigham & Womens Hosp, Sch Publ Hlth, Boston, MA 02115 USA. [Xue, Hui; Kagami, Takashi; Wang, Yuwei; Gout, Peter W.; Wang, Yu-Zhuo] British Columbia Canc Agcy, Living Tumor Lab, Vancouver, BC V5Z 4E6, Canada. [McAlpine, Jessica N.; Miller, Dianne M.] Univ British Columbia, Dept Obstet & Gynecol, Div Gynecol Oncol, Vancouver, BC V5Z 1M9, Canada. [Bowtell, David] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia. [Gilks, C. Blake; Huntsman, David G.] British Columbia Canc Agcy, Ctr Translat & Appl Genom, Vancouver Gen Hosp, Dept Pathol,Genet Pathol Evaluat Ctr, Vancouver, BC V5Z 4E6, Canada. [Ellard, Susan L.] British Columbia Canc Agcy So Interior, Dept Med Oncol, Kelowna, BC, Canada. [Wang, Yu-Zhuo] Univ British Columbia, Dept Urol Sci, Vancouver, BC V5Z 1M9, Canada. [Wang, Yu-Zhuo] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V5Z 1M9, Canada. [Vivas-Mejia, Pablo; Lopez-Berestein, Gabriel] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Lopez-Berestein, Gabriel; Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. [Lopez-Berestein, Gabriel; Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA. RP Stany, MP (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM mbirrer@partners.org RI Bowtell, David/H-1007-2016; OI Bowtell, David/0000-0001-9089-7525; Vathipadiekal, Vinod/0000-0002-8181-6890 FU National Cancer Institute at the National Institutes of the Health; OvCaRe (an initiative of the Vancouver General Hospital and University of BC Hospital Foundation and the BC Cancer Foundation); BC Cancer Foundation; Pfizer Canada FX This work was supported in part by the Intramural Research Program of the National Cancer Institute at the National Institutes of the Health (MJB) and OvCaRe (an initiative of the Vancouver General Hospital and University of BC Hospital Foundation and the BC Cancer Foundation) (YZW), the BC Cancer Foundation and Pfizer Canada (Investigator-initiated project, SLE and YZW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. NR 53 TC 37 Z9 37 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 6 PY 2011 VL 6 IS 7 AR e21121 DI 10.1371/journal.pone.0021121 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 791AK UT WOS:000292632000007 PM 21754983 ER PT J AU Chen, CH Knutson, SJ Shen, Y Wheeler, RA Horwath, JC Barnes, PN AF Chen, C. H. Knutson, S. J. Shen, Y. Wheeler, R. A. Horwath, J. C. Barnes, P. N. TI The effect of particle size on coercivity and crystallinity of SmCo5 SO APPLIED PHYSICS LETTERS LA English DT Article ID PERMANENT-MAGNETS; ENERGY PRODUCT AB It is observed a turning point in the particle size for which the coercivity H-ci of a Sm-Co alloy reaches a peak. Using a broad size range from 20 nm to 5 mm, the turning point of the flake thickness for SmCo5 nanoflakes is determined in the range of 100-180 nm with H-ci peak at similar to 20 kOe. A lower coercivity at a particle size well below the turning point is likely related to a more detailed nanoscale morphology that controls coercivity. The effect of particle size on crystallinity for high energy milled powder is also discussed with four observations. (C) 2011 American Institute of Physics. [doi:10.1063/1.3607958] C1 [Chen, C. H.; Knutson, S. J.; Shen, Y.] Univ Dayton, UDRI, Dayton, OH 45469 USA. [Chen, C. H.] GE Global Res, Niskayuna, NY 12309 USA. [Wheeler, R. A.] UES Inc, Dayton, OH 45432 USA. [Horwath, J. C.; Barnes, P. N.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Barnes, P. N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, CH (reprint author), Univ Dayton, UDRI, Dayton, OH 45469 USA. EM christina.h.chen@gmail.com FU U.S. Air Force; DOE FX This research was supported by the U.S. Air Force and DOEs ARPA-E program. NR 17 TC 26 Z9 26 U1 3 U2 33 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 4 PY 2011 VL 99 IS 1 AR 012504 DI 10.1063/1.3607958 PG 3 WC Physics, Applied SC Physics GA 791CN UT WOS:000292639200045 ER PT J AU Taylor, R Goldman, SJ AF Taylor, Robert Goldman, Scott J. TI Mitophagy and Disease: New Avenues for Pharmacological Intervention SO CURRENT PHARMACEUTICAL DESIGN LA English DT Review DE Mitophagy; autophagy; PINK1; Parkin; MMP; MPT ID VACUOLE TARGETING PATHWAY; ISOLATED RAT HEPATOCYTES; MITOCHONDRIAL PERMEABILITY TRANSITION; EARLY-ONSET PARKINSONISM; PROGRAMMED CELL-DEATH; POSTERIOR SILK GLAND; AMYLOID BETA-PEPTIDE; DROSOPHILA FAT-BODY; OXIDATIVE STRESS; ALZHEIMERS-DISEASE AB The process of intracellular macromolecular degradation known as macroautophagy has long been associated with the degradation of mitochondria. Recent studies have provided evidence that the process of mitochondria degradation via autophagy, now referred to as mitophagy, appears to be specifically targeted to mitochondria and highly regulated under both physiologic and pathologic conditions. This article provides a review of key developments in mitophagy research, including background information on the history, mechanisms, and regulation of macroautophagy, as well as discoveries that have enhanced our understanding of the specificity and independent regulation of mitophagy. This is followed by an analysis of how our current understanding of the mechanics and regulation of mitophagy may be exploited to yield pharmacological interventions for mitochondria-associated diseases. As yet, the potential for mitophagy-related pharmacological treatments for disease remains largely untapped. However, rapid progress in our understanding of both mitophagy and the pathology of mitochondria-related diseases is leading us towards the convergence of science and medicine which will inevitably result in new and potent pharmacological therapies for the treatment of these maladies. C1 [Goldman, Scott J.] USA, Vet Support & Oversight Branch, Environm Med Res Inst, Natick, MA 01760 USA. [Taylor, Robert] Univ Med & Dent New Jersey, Dept Pharmacol, Piscataway, NJ 08854 USA. RP Goldman, SJ (reprint author), USA, Vet Support & Oversight Branch, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM scott.j.goldman@us.army.mil NR 239 TC 6 Z9 8 U1 1 U2 4 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1381-6128 J9 CURR PHARM DESIGN JI Curr. Pharm. Design PD JUL PY 2011 VL 17 IS 20 BP 2056 EP 2073 PG 18 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 883HD UT WOS:000299623900006 PM 21718245 ER PT J AU Ter-Gabrielyan, N Fromzel, V Dubinskii, M AF Ter-Gabrielyan, Nikolay Fromzel, Viktor Dubinskii, Mark TI Performance analysis of the ultra-low quantum defect Er3+:Sc2O3 laser [Invited] SO OPTICAL MATERIALS EXPRESS LA English DT Article ID SESQUIOXIDES; SITES AB In this paper we report a detailed study of Er3+:Sc2O3 cryogenically cooled ceramic laser and related spectroscopic properties of Er3+:Sc2O3 in the 1500-1600 nm wavelength range. We show that two transitions between I-4(13/2) and I-4(15/2) manifolds, which are responsible for laser operation in low (at 1581 nm) and ultra-low (at 1558-1560 nm) quantum defect modes, can demonstrate equal laser efficiency. A detailed laser model that predicts the specifics of competition between these wavelengths is developed. The dependence of the laser wavelength on the gain medium temperature and cavity losses was confirmed by extensive laser experiments. An energy migration is observed between the Er3+ ions in two different symmetry sites in the Sc2O3 host. This effect along with the up-conversion process and scattering losses in laser ceramic, are the major factors limiting laser efficiency. (C) 2011 Optical Society of America C1 [Ter-Gabrielyan, Nikolay; Fromzel, Viktor; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nick.tergabrielyan@arl.army.mil NR 13 TC 6 Z9 6 U1 0 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD JUL 1 PY 2011 VL 1 IS 3 BP 503 EP 513 PG 11 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 875QD UT WOS:000299047600019 ER PT J AU Giuliani, J Masini, B Alitz, C Owens, BD AF Giuliani, Jeffrey Masini, Brendan Alitz, Curtis Owens, Brett D. TI Barefoot-simulating Footwear Associated With Metatarsal Stress Injury in 2 Runners SO ORTHOPEDICS LA English DT Article ID STRIKE PATTERNS; SHOD; ADAPTATIONS; KINEMATICS; STIFFNESS AB Stress-related changes and fractures in the foot are frequent in runners. However, the causative factors, including anatomic and kinematic variables, are not well defined. Footwear choice has also been implicated in contributing to injury patterns with changes in force transmission and gait analyses reported in the biomechanical literature. Despite the benefits of footwear, there has been increased interest among the running community in barefoot running with proposed benefits including a decreased rate of injury. We report 2 cases of metatarsal stress fracture in experienced runners whose only regimen change was the adoption of barefoot-simulating footwear. One was a 19-year-old runner who developed a second metatarsal stress reaction along the entire diaphysis. The second case was a 35-year-old ultra-marathon runner who developed a fracture in the second metatarsal diaphysis after 6 weeks of use of the same footwear. While both stress injuries healed without long-term effects, these injuries are alarming in that they occurred in experienced male runners without any other risk factors for stress injury to bone. The suspected cause for stress injury in these 2 patients is the change to barefoot-simulating footwear. Runners using these shoes should be cautioned on the potential need for gait alterations from a heel-strike to a midfoot-striking pattern, as well as cautioned on the symptoms of stress injury. C1 [Giuliani, Jeffrey; Masini, Brendan; Alitz, Curtis; Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 14 TC 35 Z9 35 U1 1 U2 54 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUL PY 2011 VL 34 IS 7 BP E320 EP E323 DI 10.3928/01477447-20110526-25 PG 4 WC Orthopedics SC Orthopedics GA 861TA UT WOS:000298040900017 PM 21717998 ER PT J AU Dongare, AM Rajendran, AM LaMattina, B Zikry, MA Brenner, DW AF Dongare, A. M. Rajendran, A. M. LaMattina, B. Zikry, M. A. Brenner, D. W. TI Dynamic Failure Behavior of Nanocrystalline Cu at Atomic Scales SO CMC-COMPUTERS MATERIALS & CONTINUA LA English DT Article DE Nanocrystalline metals; Spallation; Molecular dynamics; Voids, Dynamic failure ID VOID-GROWTH; DUCTILE FRACTURE; SPALL STRENGTH; STRAIN RATES; SOLIDS; NUCLEATION; ALUMINUM; METALS; COPPER; SYSTEM AB Large-scale molecular dynamics (MD) simulations are used to investigate the effects of microstructure and loading conditions on the dynamic failure behavior of nanocrystalline Cu. The nucleation, growth, and coalescence of voids is investigated for the nanocrystalline metal with average grain sizes ranging from 6 nm to 12 nm (inverse Hall-Retch regime) for conditions of uniaxial expansion at constant strain rates ranging from 4x10(7) s(-1) to 10(10) s(-1). MD simulations suggest that the evolution of voids can be described in two stages: The first stage corresponds to the nucleation of voids and the fast linear initial growth of all the individual voids. The second stage of void growth corresponds to the steady (slower) growth and coalescence of the void aggregates/clusters. The evolution of void fraction is found to be strongly dependent on the loading strain rates, but is less dependent on the grain size of the nanocrystalline metal. Higher strain rates require larger plastic strains to nucleate voids, whereas the larger grain sizes require lower plastic strains to nucleate voids in the inverse Hall-Petch regime. The spall strength of the nanocrystalline metal is less affected by the grain size, but is strongly affected by the loading strain rates. C1 [Dongare, A. M.; Zikry, M. A.; Brenner, D. W.] N Carolina State Univ, Raleigh, NC 27695 USA. [Rajendran, A. M.] Univ Mississippi, University, MS 38677 USA. [LaMattina, B.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM amdongare@ncsu.edu RI Brenner, Donald/D-1741-2009; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU U. S. Army Research Office (ARO) through the National Research Council FX The research was supported by the U. S. Army Research Office (ARO) through the National Research Council Research Associateship Program. NR 36 TC 4 Z9 4 U1 0 U2 13 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1546-2218 EI 1546-2226 J9 CMC-COMPUT MATER CON JI CMC-Comput. Mat. Contin. PD JUL PY 2011 VL 24 IS 1 BP 43 EP 60 PG 18 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Materials Science; Mathematics GA 845MS UT WOS:000296827500003 ER PT J AU Griffin, JR Jersey, SR AF Griffin, Jonathon R. Jersey, Sarah R. TI Evaluation of In Situ Characterization Techniques for Pavement Applications of Portland Cement-Stabilized Soil SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE soil remediation; stabilization; structural evaluation; mechanistic design; field testing; laboratory testing AB Evaluation of the structural capacity of in-service pavements with a cement-stabilized soil layer provides a unique challenge. Properties required to assess the structural capacity include strength and stiffness of the material. Traditionally these parameters are determined from laboratory testing of samples obtained in situ. Obtaining, transporting, and testing material samples are expensive procedures often not possible due to the low strength of some stabilized blends. The U.S. Army Engineer Research and Development Center investigated the potential of implementing a series of portable tools to rapidly obtain these parameters in the field. Field tests were performed at three sites, and samples were recovered and subjected to laboratory testing. Regression analyses were used to determine the existence of linear relationships between the results of the laboratory and field testing. Statistical analyses were performed to determine the validity of applying select relationships from literature and those developed in this study. The development of a reliable evaluation procedure was hindered by the inherent variability of stabilized materials. However, the devices investigated in this study should be considered for quality control testing on new construction with portland cement-stabilized soil. C1 [Griffin, Jonathon R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Jersey, Sarah R.] USA, Corps Engineers, Pittsburgh, PA 15222 USA. RP Griffin, JR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jonathon.r.griffin@usace.army.mil; sarah.r.jersey@usace.army.mil FU Headquarters, U.S. Air Force Air Combat Command; U.S. Army Engineer Research and Development Center, Waterways Experiment Station FX The tests described and the resulting data presented herein were obtained from research conducted under the combined forces Airfield Damage Repair (ADR) Civil Engineer Modernization program, sponsored by Headquarters, U.S. Air Force Air Combat Command, by the U.S. Army Engineer Research and Development Center, Waterways Experiment Station. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 22 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD JUL PY 2011 VL 34 IS 4 BP 344 EP 354 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 844OO UT WOS:000296757100007 ER PT J AU van Dongen, R Cohen, SP van Kleef, M Mekhail, N Huygen, F AF van Dongen, Robert Cohen, Steven P. van Kleef, Maarten Mekhail, Nagy Huygen, Frank TI Traumatic Plexus Lesion SO PAIN PRACTICE LA English DT Article DE evidence-based medicine; traumatic plexus lesion; spinal cord stimulation; brain stimulation; surgery ID ROOT ENTRY ZONE; TERM-FOLLOW-UP; BRACHIAL-PLEXUS; NEUROPATHIC PAIN; DEAFFERENTATION PAIN; MOTOR CORTEX; SPINAL-CORD; AVULSION; STIMULATION; GUIDELINES AB Pain, motor, and sensory deficits characterize patients with a traumatic lesion of the brachial plexus. Frequently, more severe injuries co-exist that require immediate surgical attention. Early rehabilitation and physical therapy are the cornerstones of treatment. Pharmacological management can be difficult. Surgical reconstruction is frequently advised when nerves are disrupted. The results, mostly from small historical reports, vary greatly. Neurostimulation may have an additional beneficial effect, especially if the pathophysiology of nociception and neuropathic pain becomes evident in these complex patients. C1 [van Dongen, Robert] Radboud Univ Nijmegen Med Ctr, Dept Anesthesiol Pain & Palliat Med, Nijmegen, Netherlands. [Cohen, Steven P.] Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD 21205 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [van Kleef, Maarten] Maastricht Univ Med Ctr, Dept Anesthesiol & Pain Management, Maastricht, Netherlands. [Mekhail, Nagy] Cleveland Clin, Dept Pain Management, Cleveland, OH 44106 USA. [Huygen, Frank] Erasmus MC, Dept Anesthesiol & Pain Management, Rotterdam, Netherlands. RP van Dongen, R (reprint author), Radboud Univ Nijmegen Med Ctr, Huispost 550 Anesthesiol Palliatieve Zorg,Postbus, NL-6500 HB Nijmegen, Netherlands. EM maarten.van.kleef@mumc.nl RI Dongen, R.T.M./L-4279-2015 NR 26 TC 2 Z9 2 U1 0 U2 5 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1530-7085 J9 PAIN PRACT JI Pain Pract. PD JUL-AUG PY 2011 VL 11 IS 4 BP 414 EP 420 DI 10.1111/j.1533-2500.2011.00451.x PG 7 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 840US UT WOS:000296467400012 PM 21447077 ER PT J AU Hong, SK Epureanu, BI Castanier, MP AF Hong, Sung-Kwon Epureanu, Bogdan I. Castanier, Matthew P. TI Novel Sensor Placement for Damage Identification in a Cracked Complex Structure with Structural Variability SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article; Proceedings Paper CT 3rd Annual Meeting of the ASME/AIAA Smart Materials, Adaptive Structures, and Intelligent Systems (SMASIS)/Symposium on Modeling, Simulation and Control CY SEP 28-OCT 01, 2010 CL Philadelphia, PA SP ASME, Nanotechnol Inst, AIAA DE sensor placement; damage detection; crack; structural variability; PROMs; BMA ID DYNAMIC ANALYSIS; BEAM AB The focus of this study is on sensor placement for damage detection. In particular, novel sensor placement techniques are presented to detect the length of a crack in ground vehicles. These techniques are designed to provide vibration characteristics for structures that have both cracks and structural variability. Such techniques are needed because structural variability affects the mode shapes of a structure, and thus the optimal sensor locations for detecting cracks are affected. Two key approaches are developed and used: (1) PROMs, and (2) BMA. Based on PROMs and BMA, a novel sensor placement is proposed to determine the optimal sensor locations for complex structures with cracks and structural variability. The information from the sensors can be used to determine variations in the mode shapes of the structure for different crack lengths. The variation in mode shapes can then be used to identify the crack length. Numerical results are presented for a ground vehicle frame. The sensor placement method is applied first to find the optimal sensor locations in the presence of parameter variability, and then to identify the length of a crack. C1 [Hong, Sung-Kwon; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, Matthew P.] USA, Tank Automot Res Dev & Engn Ctr Warren, Warren, MI 48397 USA. RP Epureanu, BI (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM epureanu@umich.edu OI Castanier, Matthew/0000-0002-3646-382X NR 23 TC 4 Z9 4 U1 1 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD JUL PY 2011 VL 22 IS 11 BP 1189 EP 1202 DI 10.1177/1045389X11411217 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 828XT UT WOS:000295538800007 ER PT J AU Moore, JW Hayes, SA Duffy, W Gallagher, S Michel, CJ Wright, D AF Moore, Jonathan W. Hayes, Sean A. Duffy, Walter Gallagher, Sean Michel, Cyril J. Wright, David TI Nutrient fluxes and the recent collapse of coastal California salmon populations SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID MARINE-DERIVED NUTRIENTS; PACIFIC SALMON; FRESH-WATER; ALOSA-PSEUDOHARENGUS; FOOD WEBS; TERRESTRIAL ECOSYSTEMS; RESIDENT SALMONIDS; ATLANTIC SALMON; SOCKEYE-SALMON; MARKED ANIMALS AB Migratory salmon move nutrients both in and out of fresh waters during the different parts of their life cycle. We used a mass-balance approach to quantify recent changes in phosphorus (P) fluxes in six coastal California, USA, watersheds that have recently experienced dramatic decreases in salmon populations. As adults, semelparous Chinook (Oncorhynchus tshawytscha) and coho (Oncorhynchus kisutch) salmon imported 8.3 and 10.4 times more P from the ocean, respectively, than they exported as smolts, while iteroparous steelhead (i.e., sea-run rainbow trout, Oncorhynchus mykiss) imported only 1.6 times more than they exported as kelts and smolts. Semelparous species whose life histories led them to import more nutrients were also the species whose populations decreased the most dramatically in California in recent years. In addition, the relationship between import and export was nonlinear, with export being proportionally more important at lower levels of import. This pattern was driven by two density-dependent processes - smolts were larger and disproportionately more abundant at lower spawner abundances. In fact, in four of our six streams we found evidence that salmon can drive net export of P at low abundance, evidence for the reversal of the "conveyor belt" of nutrients. C1 [Moore, Jonathan W.] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95060 USA. [Hayes, Sean A.; Michel, Cyril J.] SW Fisheries Sci Ctr, NOAA Fisheries, Santa Cruz, CA 95060 USA. [Duffy, Walter] Humboldt State Univ, USGS Calif Cooperat Fish & Wildlife, Arcata, CA 95521 USA. [Gallagher, Sean] Calif State Dept Fish & Game, Ft Bragg, CA 95437 USA. [Wright, David] Campbell Timberlands Management LLC, Ft Bragg, CA 95437 USA. RP Moore, JW (reprint author), Simon Fraser Univ, Res Grp Earth2Ocean, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada. EM jwmoore@sfu.ca FU California Fisheries Restoration Grant; NOAA Fisheries Santa Cruz; University of California Santa Cruz FX Too many individuals to mention by name from the following entities helped collect data used in this study: California Department of Fish and Game, Campbell Timberlands Management, NOAA Fisheries Santa Cruz, and the Pacific States Marine Fisheries Commission; be assured we value your help. We specifically thank Scott Harris, Shaun Thompson, Wendy Holloway, and Chris Hannon. Any use of trade names is for descriptive purposes only and does not imply endorsement by the US government. California Fisheries Restoration Grant Program funded much of the field sampling, and NOAA Fisheries Santa Cruz and University of California Santa Cruz provided financial support. We appreciate generously shared insight from experts of steelhead biology, namely George Pess, Todd Seamons, and Kent Mayer. We appreciate insightful comments from Dave Beauchamp, Mark Novak, Corey Phillis, Daniel Schindler, Mark Wipfli, and several anonymous reviewers on earlier drafts of this manuscript. NR 61 TC 12 Z9 12 U1 1 U2 27 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD JUL PY 2011 VL 68 IS 7 BP 1161 EP 1170 DI 10.1139/F2011-054 PG 10 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 824EO UT WOS:000295185400002 ER PT J AU Bahl, G Zehnpfennig, J Tomes, M Carmon, T AF Bahl, Gaurav Zehnpfennig, John Tomes, Matthew Carmon, Tal TI Stimulated optomechanical excitation of surface acoustic waves in a microdevice SO NATURE COMMUNICATIONS LA English DT Article ID WHISPERING-GALLERY MODES; RADIATION-PRESSURE; BRILLOUIN-SCATTERING; FIBER TAPER; MICROMIRROR; GENERATION; RESONATORS; EMISSION; LASER AB Stimulated Brillouin interaction between sound and light, known to be the strongest optical nonlinearity common to all amorphous and crystalline dielectrics, has been widely studied in fibres and bulk materials but rarely in optical microresonators. The possibility of experimentally extending this principle to excite mechanical resonances in photonic microsystems, for sensing and frequency reference applications, has remained largely unexplored. The challenge lies in the fact that microresonators inherently have large free spectral range, whereas the phase-matching considerations for the Brillouin process require optical modes of nearby frequencies but with different wave vectors. Here we rely on high-order transverse optical modes to relax this limitation and report the experimental excitation of mechanical resonances ranging from 49 to 1,400 M MHz by using forward Brillouin scattering. These natural mechanical resonances are excited in similar to 100 mu m silica microspheres, and are of a surface-acoustic whispering-gallery type. C1 [Bahl, Gaurav; Zehnpfennig, John; Tomes, Matthew; Carmon, Tal] Univ Michigan, Ann Arbor, MI 48109 USA. [Zehnpfennig, John] US Mil Acad, West Point, NY 10996 USA. RP Bahl, G (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA. EM bahlg@umich.edu RI Mischo, William/I-1684-2013; Bahl, Gaurav/A-5044-2014 OI Mischo, William/0000-0003-4234-9836; Bahl, Gaurav/0000-0001-7801-2739 FU DARPA ORCHID program through AFOSR FX The authors acknowledge discussions with C. X. Deng, Y.-S. Hsiao, and A. B. Matsko. This work was supported by the DARPA ORCHID program through a grant from AFOSR. NR 39 TC 80 Z9 81 U1 6 U2 47 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD JUL PY 2011 VL 2 AR 403 DI 10.1038/ncomms1412 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 819DJ UT WOS:000294805300030 PM 21792182 ER PT J AU Golden, JW Hooper, JW AF Golden, Joseph W. Hooper, Jay W. TI The strategic use of novel smallpox vaccines in the post-eradication world SO EXPERT REVIEW OF VACCINES LA English DT Review DE biological warfare; disease eradication; DNA vaccines; humoral immunity; orthopoxvirus; subunit vaccines; vaccination; variola virus; viral vectors; zoonoses ID IMMUNODEFICIENCY-VIRUS TYPE-1; INTRANASAL POXVIRUS CHALLENGE; CALF LYMPH VACCINE; PROTECTS MICE; DNA VACCINE; ANTIBODY-RESPONSES; NEUTRALIZING ANTIBODIES; MONKEYPOX VIRUS; CLINICAL-TRIAL; COWPOX VIRUS AB We still face a threat of orthopoxviruses in the form of biological weapons and emerging zoonoses. Therefore, there is a need to maintain a comprehensive defense strategy to counter the low-probability, high-impact threat of smallpox, as well as the ongoing threat of naturally occurring orthopoxvirus disease. The currently licensed live-virus smallpox vaccine ACAM2000 is effective, but associated with serious and even life-threatening adverse events. The health threat posed by this vaccine, and other previously licensed vaccines, has prevented many first responders, and even many in the military, from receiving a vaccine against smallpox. At the same time, global immunity produced during the smallpox eradication campaign is waning. Here, we review novel subunit/component vaccines and how they might play roles in unconventional strategies to defend against emerging orthopoxvirus diseases throughout the world and against smallpox used as a weapon of mass destruction. C1 [Golden, Joseph W.; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. EM jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 NR 163 TC 9 Z9 9 U1 1 U2 17 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD JUL PY 2011 VL 10 IS 7 BP 1021 EP 1035 DI 10.1586/ERV.11.46 PG 15 WC Immunology SC Immunology GA 813UD UT WOS:000294394800014 PM 21806397 ER PT J AU Worrilow, KC Uzochukwu, CD Eid, S AF Worrilow, K. C. Uzochukwu, C. D. Eid, S. TI Hyaluronan binding assay (HBAAE) and maternal age serve as positive predictors of clinical outcomes in assisted reproductive technology (ART) SO HUMAN REPRODUCTION LA English DT Meeting Abstract CT 27th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology CY JUL 03-06, 2011 CL Stockholm, SWEDEN SP European Soc Human Reprod & Embryol C1 [Worrilow, K. C.; Eid, S.] USA, KC Worrilow & Associates LLC, Fogelsville, PA USA. [Uzochukwu, C. D.] USA, Lehigh Valley Hlth Network, Allentown, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD JUL PY 2011 VL 26 SU 1 BP I171 EP I172 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 814KO UT WOS:000294450500427 ER PT J AU Ciezak, JA Jenkins, TA AF Ciezak, Jennifer A. Jenkins, Timothy A. TI Optical cell for in situ vibrational spectroscopic measurements at high pressures and shear SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article DE diamond; high-pressure techniques; phase transformations; Raman spectroscopy; vibration measurement ID DIAMOND-ANVIL CELL; X-RAY; PHASE-TRANSITIONS; RAMAN; GPA; ELASTICITY AB An optical cell is described for performing simultaneous static high-pressure and shear experiments. This cell design is a modification of the previously designed megabar diamond anvil cell used by Mao and Bell that allows for controlled, remote shear. With this diamond anvil cell, it is possible to use a wide range of existing experimental techniques and pressure media. The cell was validated on a sample of calcite at 5 kbar. Raman measurements show the onset of the phase transformation from calcite to aragonite at 10 degrees of rotation. [doi:10.1063/1.3606640] C1 [Ciezak, Jennifer A.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Jenkins, Timothy A.] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WML B, Bldg 390, Aberdeen Proving Ground, MD 21005 USA. EM Jennifer.ciezak@us.army.mil NR 28 TC 0 Z9 0 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 2011 VL 82 IS 7 AR 073905 DI 10.1063/1.3606640 PG 4 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 802GX UT WOS:000293498400033 PM 21806197 ER PT J AU Meagher, MM Seravalli, JG Swanson, ST Ladd, RG Khasa, YP Inan, M Harner, JC Johnson, SK Van Cott, K Lindsey, C Wannemacher, R Smith, LA AF Meagher, Michael M. Seravalli, Javier G. Swanson, S. Todd Ladd, Roger G. Khasa, Yogender P. Inan, Mehmet Harner, Jay C. Johnson, Scott K. Van Cott, Kevin Lindsey, Changhong Wannemacher, Robert Smith, Leonard A. TI Process Development and cGMP Manufacturing of a Recombinant Ricin Vaccine: an Effective and Stable Recombinant Ricin A-Chain Vaccine-RVEc (TM) SO BIOTECHNOLOGY PROGRESS LA English DT Article DE novel vaccine candidate; process development; cGMP lot of vaccine ID ESCHERICHIA-COLI; MONOCLONAL-ANTIBODY; PROTEIN; MUTAGENESIS; RESOLUTION; STABILITY; MECHANISM; ENTRY; 2.5-A AB Ricin is a potent toxin and a potential bioterrorism weapon with no specific countermeasures or vaccines available. The holotoxin is composed of two polypeptide chains linked by a single disulfide bond: the A-chain (RTA), which is an N-glycosidase enzyme, and the B-chain (RTB), a lectin polypeptide that binds galactosyl moieties on the surface of the mammalian target cells. Previously (McHugh et al.), a recombinant truncated form of RTA (rRTA1-33/44-198 protein, herein denoted RVEa (TM)) expressed in Escherichia coli using a codon-optimized gene was shown to be non-toxic, stable, and protective against a ricin challenge in mice. Here, we describe the process development and scale-up at the 12 L fermentation scale, and the current Good Manufacturing Practice (cGMP)-compliant production of RVEc (TM) at the 40 L scale. The average yield of the final purified bulk RVEc (TM) is approximately 16 g/kg of wet cell weight or 1.2 g/L of fermentation broth. The RVEc (TM) was >99% pure by three HPLC methods and SDS-PAGE. The intact mass and peptide mapping analysis of RVEc (TM) confirmed the identity of the product and is consistent with the absence of posttranslational modifications. Potency assays demonstrated that RVEc (TM) was immuno-protective against lethal ricin challenge and elicited neutralizing anti-ricin antibodies in 95-100% of the vaccinated mice. Published 2011 American Institute of Chemical Engineers Biotechnol. Prog., 27: 1036-1047, 2011 C1 [Lindsey, Changhong; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Off Regulated Studies, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Wannemacher, Robert] USA, Med Res Inst Infect Dis, Dept Integrated Toxicol, Ft Detrick, MD 21702 USA. [Meagher, Michael M.; Seravalli, Javier G.; Swanson, S. Todd; Ladd, Roger G.; Khasa, Yogender P.; Inan, Mehmet; Harner, Jay C.; Johnson, Scott K.; Van Cott, Kevin] Univ Nebraska, Lincoln Biol Proc Dev Facil, Coll Engn, Lincoln, NE 68588 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Off Regulated Studies, Ft Detrick, MD 21702 USA. EM leonard.smith@amedd.army.mil RI Inan, Mehmet/D-9890-2012 FU Joint Science and Technology Office for Chemical-Biological Defense (DTRA) FX This work was funded by the Joint Science and Technology Office for Chemical-Biological Defense (DTRA). The authors acknowledge the efforts of UNL BPDF staff Anthony Sump, Robert Sealock, Andrew Plum, Rick Barent, Jicai Huang, John Harms, Dustin Peterson, Anna Oommen, and Eilleen McCulloch; and the technical support of Ralph Tammariello, Richard Dinterman, Nahid Torabazari, and Rene Aguirre from USAM-RIID. The authors thank Brian Roberts (SAIC, Frederick, MD) for his critical review of the manuscript. The views and opinions expressed in this article are those of the author(s) and do not reflect official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. NR 30 TC 6 Z9 6 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD JUL-AUG PY 2011 VL 27 IS 4 BP 1036 EP 1047 DI 10.1002/btpr.631 PG 12 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 810EG UT WOS:000294107600015 PM 21630488 ER PT J AU Rogers, JV Price, JA Wendling, MQS Perry, MR Reid, FM Kiser, RC Graham, JS AF Rogers, James V. Price, Jennifer A. Wendling, Morgan Q. S. Perry, Mark R. Reid, Frances M. Kiser, Robyn C. Graham, John S. TI An Assessment of Transcriptional Changes in Porcine Skin Exposed to Bromine Vapor SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY LA English DT Article DE Bromine; Skin; Porcine; Microarray ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; RILONACEPT INTERLEUKIN-1 TRAP; GENE-EXPRESSION; SULFUR MUSTARD; HEME OXYGENASE-1; CHEMICAL BURNS; WOUND REPAIR; DIFFERENTIAL EXPRESSION; MICROARRAY ANALYSIS; PERIODIC SYNDROMES AB Bromine is an industrial chemical that can cause severe cutaneous burns. This study was a preliminary investigation into the effect of cutaneous exposure to bromine vapor using a weanling swine burn model and microarray analysis. Ventral abdominal sites were exposed to a mean calculated bromine vapor concentration of 0.69 g L(-1) for 10 or 20min. At 48 h postexposure, total RNA from skin samples was isolated, processed, and hybridized to Affymetrix GeneChip Porcine Genome Arrays. Expression analysis revealed that bromine vapor exposure for 10 or 20 min promoted similar transcriptional changes in the number of significantly modulated probe sets. A minimum of 83% of the probe sets was similar for both exposure times. Ingenuity pathways analysis revealed eight common biological functions among the top 10 functions of each experimental group, in which 30 genes were commonly shared among 19 significantly altered signaling pathways. Transcripts encoding heme oxygenase 1, interleukin-1 beta, interleukin 2 receptor gamma chain, and plasminogen activator inhibitor-1 were identified as common potential therapeutic targets for Phase II/III clinical trial or FDA-approved drugs. The present study is an initial assessment of the transcriptional responses to cutaneous bromine vapor exposure identifying molecular networks and genes that could serve as targets for developing therapeutics for bromine-induced skin injury. C (C) 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:252-262, 2011; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20383 C1 [Rogers, James V.; Price, Jennifer A.; Wendling, Morgan Q. S.; Perry, Mark R.; Reid, Frances M.; Kiser, Robyn C.] Battelle Biomed Res Ctr, Columbus, OH 43201 USA. [Graham, John S.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Rogers, JV (reprint author), Battelle Biomed Res Ctr, Columbus, OH 43201 USA. EM rogersjv@battelle.org FU DTRA/CBMS/MRMC [W81XWH-05-D-0001]; U.S. Army Medical Research Institute of Chemical Defense (USAMRICD); National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID) [Y1-AI-6177-02] FX This work was conducted under DTRA/CBMS/MRMC contract W81XWH-05-D-0001, Task Order 0010 with funding support through an Interagency Agreement (IAA) between the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) and National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA number Y1-AI-6177-02. NR 64 TC 5 Z9 5 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1095-6670 J9 J BIOCHEM MOL TOXIC JI J. Biochem. Mol. Toxicol. PD JUL-AUG PY 2011 VL 25 IS 4 BP 252 EP 262 DI 10.1002/jbt.20383 PG 11 WC Biochemistry & Molecular Biology; Toxicology SC Biochemistry & Molecular Biology; Toxicology GA 811HV UT WOS:000294200400007 PM 21391292 ER PT J AU Cator, LJ Arthur, BJ Ponlawat, A Harrington, LC AF Cator, Lauren J. Arthur, Benjamin J. Ponlawat, Alongkot Harrington, Laura C. TI Behavioral Observations and Sound Recordings of Free-Flight Mating Swarms of Ae. aegypti (Diptera: Culicidae) in Thailand SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; mating; bioacoustics ID ANOPHELES-GAMBIAE; AEDES-AEGYPTI; ALBOPICTUS DIPTERA; MOSQUITOS; TONE AB Sound plays an important role in the mating behavior of mosquitoes, including Aedes aegypti (L). Males orient to the fundamental wing beat frequency of females, and both sexes actively modulate their flight tone before mating to converge at harmonic frequencies. The majority of studies on mosquito mating acoustics have been conducted in the laboratory using tethered individuals. In this study, we present the first free-flight recording of naturally forming Ae. aegypti swarms in Thailand. We describe mating behaviors and present results on the flight tone frequency and dynamics of wild pairs in free flight. To assess the importance of these behaviors in vector control programs, especially those using genetically modified mosquitoes, it will be critical to use methods, such as those described in this work, to measure mosquito mating behaviors in the field. C1 [Cator, Lauren J.; Harrington, Laura C.] Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA. [Arthur, Benjamin J.] Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA. [Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. RP Cator, LJ (reprint author), Cornell Univ, Dept Entomol, 3131 Comstock Hall, Ithaca, NY 14853 USA. EM ljc47@cornell.edu FU Centers for Disease Control and Prevention Dissertations in Public Health [1R36CK000130-01]; National Institutes of Health, Health and Human Services [2R01 DC000103] FX We thank the staff of the United States Army Medical Component of the Armed Forces Research Institute of the Medical Sciences (Bangkok, Thailand) and the field crew in Kamphaeng Phet, Thailand. We also thank the residents of Kamphaeng Phet for allowing us to conduct recordings in their homes. This work was supported by Centers for Disease Control and Prevention Dissertations in Public Health Grant 1R36CK000130-01 (to L.J.C.) and National Institutes of Health, Health and Human Services, Grant 2R01 DC000103 (to B.J.A.). NR 27 TC 12 Z9 13 U1 2 U2 24 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2011 VL 48 IS 4 BP 941 EP 946 DI 10.1603/ME11019 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 810KJ UT WOS:000294123900030 PM 21845959 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI The Civil War Naval Encyclopedia SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Weddle, Kevin J.] USA, War Coll, Carlisle, PA USA. RP Weddle, KJ (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2011 VL 75 IS 3 BP 928 EP 929 PG 2 WC History SC History GA 793VE UT WOS:000292851200033 ER PT J AU House, JM AF House, Jonathan M. TI The Soviet Union at War, 1941-1945 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA Command, Ft Leavenworth, KS USA. [House, Jonathan M.] Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA Command, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2011 VL 75 IS 3 BP 956 EP 957 PG 2 WC History SC History GA 793VE UT WOS:000292851200052 ER PT J AU Kuehn, JT AF Kuehn, John T. TI Untitled SO JOURNAL OF MILITARY HISTORY LA English DT Letter C1 US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Kuehn, JT (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2011 VL 75 IS 3 BP 1004 EP 1004 PG 1 WC History SC History GA 793VE UT WOS:000292851200072 ER PT J AU Bookstaver, DA Hatzigeorgiou, C AF Bookstaver, David A. Hatzigeorgiou, Christos TI Assessment of the White-Coat Effect Among Hypertensive Patients Presumed to Be at Goal SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE ambulatory blood pressure monitoring; hypertension; white-coat effect ID AMBULATORY BLOOD-PRESSURE; RESISTANT HYPERTENSION; TREATED HYPERTENSION; PROGNOSTIC VALUE; PRIMARY-CARE; DETERMINANTS; ASSOCIATION; PREDICTORS; EDUCATION; DECLINE AB BACKGROUND: There are limited studies that explore the rate of existent uncontrolled hypertension versus a significant white-coat effect. Likewise, few studies have described the physician's response to the results of an ambulatory blood pressure monitoring (ABPM) study. OBJECTIVE: To determine the percentage of treated hypertensive patients referred for ABPM based on discrepant office and home blood pressures who had achieved goal blood pressure and to determine the degree of white-coat effect in these patients. METHODS: Medical records of 222 consecutive patients were reviewed. Patients without a clinic visit since a medication change and those with <70% valid readings on ABPM were excluded. The proportion of patients at their goal blood pressure during ABPM was determined. Clinic blood pressure readings prior to ABPM were compared to daytime ABPM readings to calculate the white-coat effect. The percentage of patients whose blood pressure decreased by 10% or more in the night interval versus the daytime period was calculated. Changes to antihypertensive therapy were determined for the 6-month post-ABPM period. RESULTS: One hundred ninety-three patients met the inclusion criteria. Mean (SD) clinic blood pressure was 158/77 (13/10) mm Hg, compared to mean daytime ABPM readings of 127/70 (12/9) mm Hg. Sixty-seven percent of patients were at goal blood pressure. The mean white-coat effect was 3117 (16/9) mm Hg and was significantly greater in patients who were at goal versus those who were not (p < 0.01). A 10% or higher overnight dip occurred in 28% of those at goal. Therapy was not escalated 6 months after ABPM in 91% of patients who were at goal during the test despite a mean post-ABPM clinic blood pressure of 151/74 mm Hg. CONCLUSIONS: The majority of patients with incongruent clinic and home blood pressure readings were at goal after ABPM evaluation. Further study is needed regarding demographic or clinical characteristics that can be used to help predict which patients may be experiencing a significant white-coat effect and are actually at goal in an ambulatory setting. C1 [Bookstaver, David A.] Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA 30905 USA. [Hatzigeorgiou, Christos] Eisenhower Army Med Ctr, Internal Med Clin, Dept Med, Ft Gordon, GA USA. RP Bookstaver, DA (reprint author), Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA 30905 USA. EM david.bookstaver@amedd.army.mil NR 26 TC 0 Z9 0 U1 0 U2 2 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD JUL-AUG PY 2011 VL 45 IS 7-8 BP 910 EP 915 DI 10.1345/aph.1P771 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 800OG UT WOS:000293370300009 PM 21750311 ER PT J AU Cookman, L Skinner, CG Von Derau, K Miller, M AF Cookman, Laura Skinner, Carl G. Von Derau, Katie Miller, Michael TI A RETROSPECTIVE REVIEW OF POISON CENTER CALLS WITH PATIENTS EXPOSED TO 'SPICE' PRODUCTS SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract C1 [Von Derau, Katie] Washington Poison Ctr, Seattle, WA USA. [Cookman, Laura; Skinner, Carl G.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Miller, Michael] Tripler Army Med Ctr, Hawaii, HI USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD JUL PY 2011 VL 49 IS 6 MA 36 BP 531 EP 531 PG 1 WC Toxicology SC Toxicology GA 804YS UT WOS:000293692600065 ER PT J AU Dean, RN Castro, ST Flowers, GT Roth, G Ahmed, A Hodel, AS Grantham, BE Bittle, DA Brunsch, JP AF Dean, Robert Neal Castro, Simon Thomas Flowers, George T. Roth, Grant Ahmed, Anwar Hodel, Alan Scottedward Grantham, Brian Eugene Bittle, David Allen Brunsch, James P., Jr. TI A Characterization of the Performance of a MEMS Gyroscope in Acoustically Harsh Environments SO IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS LA English DT Article DE Acoustics; harsh environment; MEMS gyroscope AB Microelectromechanical systems (MEMS) gyroscopes are typically smaller and less expensive than their macroscale counterparts. For this reason, they are being used in many new applications, including in harsh environments. It has been well documented that the performance of unprotected MEMS gyroscopes can be deleteriously affected by exposure to mechanical shock or high-frequency vibrations. The results of this investigation experimentally demonstrate that MEMS gyroscopes are also susceptible to high-power high-frequency acoustic noise when acoustic energy frequency components are close to the resonating frequency of the gyroscope's proof mass. Additionally, due to microfabrication tolerances and the resulting differences between otherwise identical devices, there can be significant differences in the acoustically sensitive bandwidth between otherwise identical MEMS gyroscopes. This phenomenon is characterized for the ADXRS300 MEMS gyroscope. C1 [Dean, Robert Neal; Hodel, Alan Scottedward] Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. [Castro, Simon Thomas] AT&T, Dallas, TX 75201 USA. [Flowers, George T.] Auburn Univ, Dept Mech Engn, Auburn, AL 36849 USA. [Roth, Grant; Grantham, Brian Eugene; Bittle, David Allen] USA, Huntsville, AL 35898 USA. [Ahmed, Anwar] Auburn Univ, Dept Aerosp Engn, Auburn, AL 36849 USA. [Brunsch, James P., Jr.] MEMSense LLC, Rapid City, SD 57702 USA. RP Dean, RN (reprint author), Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. EM deanron@auburn.edu; castrst@auburn.edu; flowegt@auburn.edu; rothgra@auburn.edu; ahmedan@auburn.edu; brian.e.grantham@us.army.mil; David.Bittle@us.army.mil; jbrunsch@memsense.com NR 21 TC 14 Z9 15 U1 1 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0278-0046 EI 1557-9948 J9 IEEE T IND ELECTRON JI IEEE Trans. Ind. Electron. PD JUL PY 2011 VL 58 IS 7 BP 2591 EP 2596 DI 10.1109/TIE.2010.2070772 PG 6 WC Automation & Control Systems; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA 806SU UT WOS:000293832600003 ER PT J AU Geis, JP Parnell, GS Newton, H Bresnick, T AF Geis, John P., II Parnell, Gregory S. Newton, Harry Bresnick, Terry TI Blue Horizons Study Assesses Future Capabilities and Technologies for the United States Air Force SO INTERFACES LA English DT Article DE defense; decision analysis; multiple criteria; research and development; technology; uncertainty; scenarios AB The purpose of the Blue Horizons study was to determine the capabilities and technologies in which the United States Air Force would need to invest to maintain dominant air, space, and cyberspace capabilities in the year 2030. The study used two methodologies, scenario analysis and multiobjective decision analysis, to evaluate 58 future-system concepts and 172 key enabling technologies. The paper outlines the study's key conclusions and recommendations to the Air Force, including recommendations on how future concepts and technologies would help it to prepare for disparate potential challenges, such as rising peer competitors, the problem of failed states, and continued insurgencies in far-flung parts of the world. C1 [Geis, John P., II] Univ Air, USAF, Ctr Strategy & Technol, Maxwell AFB, AL 36112 USA. [Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Parnell, Gregory S.; Newton, Harry; Bresnick, Terry] Innovat Decis Inc, Vienna, VA 22182 USA. RP Geis, JP (reprint author), Univ Air, USAF, Ctr Strategy & Technol, Maxwell AFB, AL 36112 USA. EM john.geis@maxwell.af.mil; gregory.parnell@usma.edu; harry.newton@innovativedecisions.com; tabresnick@innovativedecisions.com NR 20 TC 1 Z9 1 U1 0 U2 3 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 0092-2102 J9 INTERFACES JI Interfaces PD JUL PY 2011 VL 41 IS 4 BP 338 EP 353 DI 10.1287/inte.1110.0556 PG 16 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 807JW UT WOS:000293894400002 ER PT J AU Michener, LA Doukas, WC Murphy, KP Walsworth, MK AF Michener, Lori A. Doukas, William C. Murphy, Kevin P. Walsworth, Matthew K. TI Diagnostic Accuracy of History and Physical Examination of Superior Labrum Anterior-Posterior Lesions SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE labral tears; diagnostic tests; sensitivity; specificity; likelihood ratio ID SLAP LESIONS; TEARS; TESTS; SHOULDER AB Context: Type I superior labrum anterior-posterior (SLAP) lesions involve degenerative fraying and probably are not the cause of shoulder pain. Type II to IV SLAP lesions are tears of the labrum. Objective: To determine the diagnostic accuracy of patient history and the active compression, anterior slide, and crank tests for type I and type II to IV SLAP lesions. Design: Cohort study. Setting: Clinic. Patients or Other Participants: Fifty-five patients (47 men, 8 women; age=40.6 +/- 15.1 years) presenting with shoulder pain. Intervention(s): For each patient, an orthopaedic surgeon conducted a clinical examination of history of trauma; sudden onset of symptoms; history of popping, clicking, or catching; age; and active compression, crank, and anterior slide tests. The reference standard was the intraoperative diagnosis. The operating surgeon was blinded to the results of the clinical examination. Main Outcome Measure(s): Diagnostic utility was calculated using the receiver operating characteristic curve and area under the curve (AUC), sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood ratio (-LR). Forward stepwise binary regression was used to determine a combination of tests for diagnosis. Results: No history item or physical examination test had diagnostic accuracy for type I SLAP lesions (n =13). The anterior slide test had utility (AUC = 0.70, +LR = 2.25, -LR = 0.44) to confirm and exclude type II to IV SLAP lesions (n=10). The combination of a history of popping, clicking, or catching and the anterior slide test demonstrated diagnostic utility for confirming type II to IV SLAP lesions (+LR = 6.00). Conclusions: The anterior slide test had limited diagnostic utility for confirming and excluding type II to IV SLAP lesions; diagnostic values indicated only small shifts in probability. However, the combination of the anterior slide test with a history of popping, clicking, or catching had moderate diagnostic utility for confirming type II to IV SLAP lesions. No single item or combination of history items and physical examination tests had diagnostic utility for type I SLAP lesions. C1 [Michener, Lori A.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA 23298 USA. [Doukas, William C.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Murphy, Kevin P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Murphy, Kevin P.] Heekin Orthopaed Specialists, Jacksonville, FL USA. [Walsworth, Matthew K.] Virginia Commonwealth Univ Hlth Syst, Med Coll Virginia, Dept Radiol, Richmond, VA USA. RP Michener, LA (reprint author), Virginia Commonwealth Univ, Dept Phys Therapy, Room 100,1200 E Broad St, Richmond, VA 23298 USA. EM lamichen@vcu.edu NR 20 TC 5 Z9 6 U1 1 U2 10 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD JUL-AUG PY 2011 VL 46 IS 4 BP 343 EP 348 PG 6 WC Sport Sciences SC Sport Sciences GA 808NA UT WOS:000293983200003 PM 21944065 ER PT J AU Cooper, GR Costello, M AF Cooper, G. R. Costello, Mark TI Trajectory Prediction of Spin-Stabilized Projectiles with a Liquid Payload SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID FILLED PROJECTILES AB Payloads that behave like a liquid are carried onboard some projectile configurations, and it is well established that the internal motion of a liquid payload can induce destabilizing moments on the projectile. This paper creates a method to include the effect of a liquid payload in the flight dynamic equations of motion, enabling trajectory simulations of projectiles with liquid payloads. To include this effect, liquid payload moments are added to the applied loads on the projectile. These loads are computed by solving the linearized Navier-Stokes equations for a projectile undergoing coning motion. To highlight the methodology, trajectory simulation results are provided for an example projectile with different liquid payloads configurations possessing stable behavior while one exhibits catastrophic flight instability. C1 [Cooper, G. R.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Costello, Mark] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. RP Cooper, GR (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 21 TC 3 Z9 3 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JUL-AUG PY 2011 VL 48 IS 4 BP 664 EP 670 DI 10.2514/1.52564 PG 7 WC Engineering, Aerospace SC Engineering GA 804UM UT WOS:000293679500013 ER PT J AU Martini, WZ AF Martini, Wenjun Z. TI Fibrinogen Availability and Coagulation Function after Hemorrhage and Resuscitation in Pigs SO MOLECULAR MEDICINE LA English DT Article ID PROTHROMBIN COMPLEX CONCENTRATE; CARDIOPULMONARY BYPASS; TRANSFUSION ALGORITHM; CARDIAC-SURGERY; PLATELET; EFFICACY; THROMBOELASTOGRAPHY; THROMBELASTOGRAPHY; THROMBOCYTOPENIA; PROTEINS AB Hemorrhagic coagulopathy (without neurological injuries) constitutes 40% of injury-related death in civilian hospitals and on the battlefield, and the underlying contributing mechanisms remain unclear. The purpose of this study is to investigate the effects of fibrinogen availability on coagulation function after hemorrhage in pigs. Sixteen crossbred commercial Yorkshire swine were randomized into the control group (group C) (n = 8) and hemorrhage group (group H) (n = 8). Hemorrhage was induced in group H by bleeding 35% of the estimated total blood volume, followed by resuscitation with lactated Ringer solution at three times the bled volume. Pigs in group C were not hemorrhaged or resuscitated. Blood samples were withdrawn at baseline, 15 min, 3 h, 6 h, and 24 h after hemorrhage and lactated Ringer (LR) resuscitation (H-LR). Coagulation was assessed by using thrombelastography. All baseline measurements were similar between groups C and H. Hemorrhage caused a decrease in mean arterial pressure and an increase in heart rate in group H, but LR resuscitation corrected these changes within 1 h. Compared to baseline values, fibrinogen concentrations in group H decreased at 15 min, 3 h and 6 h after H-LR, but increased to double that of the baseline value at 24 h; platelet counts decreased throughout the study; clot strength was decreased at 15 min, 3 h and 6 h, but returned to baseline value at 24 h after H-LR. Hemorrhage caused decreases in fibrinogen and platelets, and compromised clot strength. The rebound of fibrinogen at 24 h restored clot strength despite platelet deficit. These data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3400 Rowley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil FU Veterinary Support Division at the United States Army Institute of Surgical Research; Laboratory Support Division at the United States Army Institute of Surgical Research; United States Army Medical Research and Materiel Command FX The author appreciates the support received from the Veterinary Support Division and the Laboratory Support Division at the United States Army Institute of Surgical Research in animal studies and coagulation measurements. The author thanks Mrs. Shavaughn Colvin for her excellent technical assistance during the study.; This study was supported by the United States Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the author and are not to be constructed as official or as reflecting the views of the United States Department of the Army or the United States Department of Defense. NR 24 TC 11 Z9 12 U1 0 U2 0 PU FEINSTEIN INST MED RES PI MANHASSET PA 350 COMMUNITY DR, MANHASSET, NY 11030 USA SN 1076-1551 J9 MOL MED JI Mol. Med. PD JUL-AUG PY 2011 VL 17 IS 7-8 BP 757 EP 761 DI 10.2119/molmed.2010.00093 PG 5 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 804VH UT WOS:000293681600020 PM 21327301 ER PT J AU Porter, A Phillips, G Smith, L Erwin-Cohen, R Tammariello, R Hale, M DaSilva, L AF Porter, Aimee Phillips, Gary Smith, Leonard Erwin-Cohen, Rebecca Tammariello, Ralph Hale, Martha DaSilva, Luis TI Evaluation of a ricin vaccine candidate (RVEc) for human toxicity using an in vitro vascular leak assay SO TOXICON LA English DT Article DE Ricin; Ricin vaccine - RVEc; Vascular leak; Trans-endothelial electrical resistance; Cytotoxicity ID ENDOTHELIAL-CELLS; A-CHAIN; TOXIN; PERMEABILITY; IMMUNOTOXINS; STABILITY; INCREASES; MECHANISM; ANTIBODY; DAMAGE AB To protect against ricin intoxication, a genetically derived ricin A chain vaccine candidate (RVEc) was developed lacking the toxic N-glycosidase activity (Olson et al., 2004). The vaccine protects animals against an aerosolized ricin holotoxin (RT) challenge (Carra et al., 2007). In the current study, the RVEc vaccine was evaluated for its interaction and effect on human endothelial cells. RVEc was tested in an in vitro cellular-based bioassay, consisting of primary human endothelial cells cultured on collagen-coated inserts, to which concentrations of the vaccine candidate (0.6, 2, 2.5 or 9 mu M) were added. RVEc showed no signs of adverse activity on the cells (e.g., cytotoxicty activity) as measured by changes in trans-endothelial electrical resistance (TEER). In contrast, ricin toxin (RT) cytotoxicity was observed at all concentrations tested. Under light microscopy, no cytotoxicity was visible at 24 h with 0.6 or 9 mu M of RVEc. However, cytotoxicity was observed for RT and to a lesser degree for RTA. Flow cytometric analysis showed binding of RT, slight binding of RTA, and no binding of the RVEc vaccine to endothelial cells. The presence of RTB as a contaminant contributing to the cytotoxicity in the RTA preparation was ruled out by a RIB-specific ELISA. In addition, RTA at 9 mu Mproduced a cytotoxic activity that could not be explained exclusively by the presence of azide in the RTA buffer. In the current study, the model demonstrated no discernable adverse events of the RVEc vaccine on human endothelial cells, when compared to the toxicity caused by holotoxin or native RTA preparations. Published by Elsevier Ltd. C1 [Porter, Aimee; Erwin-Cohen, Rebecca; DaSilva, Luis] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Phillips, Gary] Def Sci & Technol Lab, Dept Biomed Sci, Salisbury, Wilts, England. [Tammariello, Ralph; Hale, Martha] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP DaSilva, L (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM Luis.DaSilva@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.1B0004_07_RD_B] FX The work was supported by the Defense Threat Reduction Agency (DTRA), JSTO-CBD Project # 1.1B0004_07_RD_B. NR 23 TC 9 Z9 10 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUL PY 2011 VL 58 IS 1 BP 68 EP 75 DI 10.1016/j.toxicon.2011.05.005 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 809DC UT WOS:000294031000009 PM 21616091 ER PT J AU Olulade, O Hu, S Gonzalez-Castillo, J Tamer, GG Luh, WM Ulmer, JL Talavage, TM AF Olulade, O. Hu, S. Gonzalez-Castillo, J. Tamer, G. G., Jr. Luh, W. -M. Ulmer, J. L. Talavage, T. M. TI Assessment of temporal state-dependent interactions between auditory fMRI responses to desired and undesired acoustic sources SO HEARING RESEARCH LA English DT Article ID EVENT-RELATED FMRI; FUNCTIONAL MRI; HEMODYNAMIC-RESPONSES; BOLD RESPONSE; HUMAN BRAIN; VOLUME MEASUREMENT; CORTICAL AREAS; GRADIENT NOISE; SCANNER NOISE; CORTEX AB A confounding factor in auditory functional magnetic resonance imaging (fMRI) experiments is the presence of the acoustic noise inherently associated with the echo planar imaging acquisition technique. Previous studies have demonstrated that this noise can induce unwanted neuronal responses that can mask stimulus-induced responses. Similarly, activation accumulated over multiple stimuli has been demonstrated to elevate the baseline, thus reducing the dynamic range available for subsequent responses. To best evaluate responses to auditory stimuli, it is necessary to account for the presence of all recent acoustic stimulation, beginning with an understanding of the attenuating effects brought about by interaction between and among induced unwanted neuronal responses, and responses to desired auditory stimuli. This study focuses on the characterization of the duration of this temporal memory and qualitative assessment of the associated response attenuation. Two experimental parameters - inter-stimulus interval (ISI) and repetition time (TR) - were varied during an fMRI experiment in which participants were asked to passively attend to an auditory stimulus. Results present evidence of a state-dependent interaction between induced responses. As expected, attenuating effects of these interactions become less significant as TR and ISI increase and in contrast to previous work, persist up to 18s after a stimulus presentation. (C) 2011 Elsevier B.V. All rights reserved. C1 [Olulade, O.; Talavage, T. M.] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA. [Olulade, O.] Georgetown Univ, Med Ctr, Ctr Study Learning, Washington, DC 20007 USA. [Hu, S.] USA, Res Lab, Adelphi, MD USA. [Gonzalez-Castillo, J.; Tamer, G. G., Jr.; Talavage, T. M.] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA. [Luh, W. -M.] NIMH, Funct MRI Facil, NIH, Bethesda, MD 20892 USA. [Ulmer, J. L.] Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA. RP Olulade, O (reprint author), Purdue Univ, Sch Elect & Comp Engn, EE Bldg,465 Northwestern Ave, W Lafayette, IN 47907 USA. EM oao24@georgetown.edu; shuowen.hu@us.army.mil; javier.gonzalez-castillo@nih.gov; gtamer@purdue.edu; luhw@mail.nih.gov; julmer@mcw.edu; tmt@ecn.purdue.edu RI Gonzalez-Castillo, Javier/B-6903-2012; OI Gonzalez-Castillo, Javier/0000-0002-6520-5125 FU NIH [R01EB003990]; National Institute of Mental Health FX The authors wish to thank Dr. Robert W. Prost and Cathy S. Marszalkowski for their assistance in the execution of this project. This research was supported in part by NIH grant R01EB003990 and the Intramural Research Program of the National Institute of Mental Health. NR 57 TC 8 Z9 8 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD JUL PY 2011 VL 277 IS 1-2 BP 67 EP 77 DI 10.1016/j.heares.2011.03.008 PG 11 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 805KZ UT WOS:000293726600009 PM 21426929 ER PT J AU Bernstein, JGW Brungart, DS AF Bernstein, Joshua G. W. Brungart, Douglas S. TI Effects of spectral smearing and temporal fine-structure distortion on the fluctuating-masker benefit for speech at a fixed signal-to-noise ratio SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HEARING-IMPAIRED LISTENERS; AMPLITUDE-MODULATED NOISE; AUDITORY FILTER SHAPES; MASKING RELEASE; STRUCTURE INFORMATION; RECEPTION THRESHOLD; INTELLIGIBILITY INDEX; SIMULTANEOUS TALKERS; INTERFERING SPEECH; INTERRUPTED NOISE AB Normal-hearing listeners receive less benefit from momentary dips in the level of a fluctuating masker for speech processed to degrade spectral detail or temporal fine structure (TFS) than for unprocessed speech. This has been interpreted as evidence that the magnitude of the fluctuating-masker benefit (FMB) reflects the ability to resolve spectral detail and TFS. However, the FMB for degraded speech is typically measured at a higher signal-to-noise ratio (SNR) to yield performance similar to normal speech for the baseline (stationary-noise) condition. Because the FMB decreases with increasing SNR, this SNR difference might account for the reduction in FMB for degraded speech. In this study, the FMB for unprocessed and processed (TFS-removed or spectrally smeared) speech was measured in a paradigm that adjusts word-set size, rather than SNR, to equate stationary-noise performance across processing conditions. Compared at the same SNR and percent-correct level (but with different set sizes), processed and unprocessed stimuli yielded a similar FMB for four different fluctuating maskers (speech-modulated noise, one opposite-gender interfering talker, two same-gender interfering talkers, and 16-Hz interrupted noise). These results suggest that, for these maskers, spectral or TFS distortions do not directly impair the ability to benefit from momentary dips in masker level. [DOI: 10.1121/1.3589440] C1 [Bernstein, Joshua G. W.; Brungart, Douglas S.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Bernstein, JGW (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. EM joshua.g.bernstein@us.army.mil FU NIH-NIDCD [R03 DC 010264]; Oticon Foundation FX This work was supported by grants from the NIH-NIDCD (R03 DC 010264) and the Oticon Foundation. We thank Sandeep Phatak, Kenneth Jensen, and two anonymous reviewers for providing helpful comments on an earlier version of the manuscript. We thank Brian Moore and Kathryn Hopkins for providing the signal-processing software used to apply the spectral-smearing and noise-vocoding algorithms. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or U.S. Government. NR 58 TC 30 Z9 30 U1 2 U2 8 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2011 VL 130 IS 1 BP 473 EP 488 DI 10.1121/1.3589440 PG 16 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 794SD UT WOS:000292920700053 PM 21786913 ER PT J AU Taylor, S Guan, Y Matrajt, G AF Taylor, S. Guan, Y. Matrajt, G. TI ATMOSPHERIC OXYGEN EXCHANGE IN MICROMETEORITES SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 74th Annual Meeting of the Meteoritical-Society CY AUG 08-12, 2011 CL London, ENGLAND SP Meteorit Soc, Nat Hist Museum, Imperial Coll, Lunar & Planetary Inst, Natl Aeronaut & Space Adm, European Space Agcy, Barringer Crater Co, CAMECA Instruments, Bruker Nano GmbH, CEPSAR - Open Univ, Univ Leicester, Space Res Ctr, Univ Glasgow, Cambridge Univ Press, Sci (AAAS), WiTec GmbII, Royal Observ Greenwich C1 [Taylor, S.] CRREL, Hanover, NH 03755 USA. [Guan, Y.] CALTECH, Pasadena, CA 91125 USA. [Matrajt, G.] Univ Washington, Dept Astron, Seattle, WA 98105 USA. NR 3 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2011 VL 46 SU 1 SI SI BP A231 EP A231 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 797AN UT WOS:000293094700459 ER PT J AU Batyrev, IG Sarney, WL Zheleva, TS Nguyen, C Rice, BM Jones, KA AF Batyrev, I. G. Sarney, W. L. Zheleva, T. S. Nguyen, C. Rice, B. M. Jones, K. A. TI Dislocations and stacking faults in hexagonal GaN SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article DE defect levels; hexagonal GaN; MOCVD; partial dislocations; simulations; stacking faults; TEM ID ELECTRONIC-STRUCTURE; INN; ALN AB We present experimental and theoretical results on extended defects of hexagonal GaN grown by metal organic vapour deposition (MOCVD). Transmission electron microscopy (TEM) measurements indicate the presence of 3 nm wide type I(1) stacking faults (SFs) related to the MOCVD growth, and 2-4 nm SFs of unidentified type related to the ion implantation. We simulated infinite SFs of different types I(1), I(2) and I(3). First principles calculations were used to model Shockley partial dislocations, the core structure of the dislocations and intrinsic SFs. We estimate defect level positions and the formation energy of the infinite SFs. We also present results of the calculations and available experimental data on finite size SFs bounded by partial dislocations in wurtzite GaN. Calculation of the infinite SFs revealed shallow levels, but no deep levels. In the SFs bound by dislocations there are deep filled levels in the range of 0.4-0.8 eV from the valence band maximum (VBM) located at the atoms of the 90 degrees dislocations. We also calculated the segregation of the C, n-dopant, Si or O and the p-dopant, Mg, to the dislocations and SFs. The effect of the segregation is found to be stronger for the SFs with partials. The results of the calculations are correlated with the experimental data on GaN obtained from high resolution TEM and Hall measurements. We suggest mechanisms of the formation of the SFs I(1) and I(2) after ion implantation and high temperature anneal and explain the difficulties of p-type doping with the formation of the extended defects. (C) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Batyrev, I. G.; Rice, B. M.] USA, Res Lab, Aberdeen Proving Ground, MD 21001 USA. [Sarney, W. L.; Zheleva, T. S.; Nguyen, C.; Jones, K. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Batyrev, IG (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21001 USA. EM sasha.batyrev@us.army.mil NR 8 TC 8 Z9 8 U1 5 U2 63 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1862-6300 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD JUL PY 2011 VL 208 IS 7 BP 1566 EP 1568 DI 10.1002/pssa.201001061 PG 3 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 806JL UT WOS:000293803600023 ER PT J AU Lehman, RA AF Lehman, Ronald A., Jr. TI Postoperative lymphocele after revision circumferential long-segment scoliosis construct for pseudarthrosis SO SPINE JOURNAL LA English DT Editorial Material C1 [Lehman, Ronald A., Jr.] Uniformed Serv Univ Hlth Sci, Div Orthopaed, Dept Surg, Potomac, MD 20854 USA. [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. RP Lehman, RA (reprint author), Uniformed Serv Univ Hlth Sci, Div Orthopaed, Dept Surg, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD JUL PY 2011 VL 11 IS 7 BP 684 EP 685 DI 10.1016/j.spinee.2011.05.012 PG 2 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 803PF UT WOS:000293592500022 PM 21719353 ER PT J AU Conti, G Caroland, J AF Conti, Gregory Caroland, James TI Embracing the Kobayashi Maru Why You Should Teach Your Students to Cheat SO IEEE SECURITY & PRIVACY LA English DT Article C1 [Conti, Gregory] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Conti, G (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM gregory.conti@usma.edu; jlcarol@cybercom.mil NR 0 TC 3 Z9 3 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD JUL-AUG PY 2011 VL 9 IS 4 BP 48 EP 51 PG 4 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 800LP UT WOS:000293361700007 ER PT J AU Douglas, SE Caldwell, BS AF Douglas, Stephen E. Caldwell, Barrett S. TI Design and validation of an Individual Health Report (IHR) SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Heath communication; Health literacy; Health status information; Prototype testing; User-centered design; Visual information design ID CARE AB This research focused on developing a general health report that conveys an individual's health readings in a clear, concise and explanatory manner and demonstrating the report's usefulness. The research examined the need for such a report and focused the design on the determined need and communication through visual display. The designed "Individual Health Report (IHR)" was evaluated using data obtained from an online survey developed for this research. The analysis involved t-tests, McNemar's tests, linear regression and ANOVA. Results included the finding that the IHR significantly improved respondent's ability to correctly answer questions about their health status and preventive health in general (p < 0.0001, n = 61). The study also showed that introduction of the IHR by healthcare providers would significantly improve the respondents' view that they get the preventive healthcare information they need to make appropriate decisions (p = 0.0007, n = 61). In an era when costs of healthcare are of great concern and prevention is starting to gain traction as compared to strictly treatment, an IHR could be a very practical and beneficial step toward prevention focused healthcare. An IHR could be considered as a tool to provide increased public awareness of health status, with resulting gains in proactive and effective health management choices. Relevance to Industry: Degraded health and associated healthcare costs are of significant concerns to industry performance and profits. As several references highlighted in this research have indicated, a lack of health literacy and awareness of critical health indicators are significant concerns in helping employees to manage their own health status. From an economic and societal perspective, it may be considered cost effective for employers to work with healthcare providers to support presentation of employee health status and results of recent healthcare evaluations by means of an IHR. An IHR of the type tested in this research can be seen to both provide clear and understandable health status information, and improve health literacy, for wide sections of the population. Presenting employee information via this type of IHR can effectively supplement healthcare information delivered by healthcare providers. The IHR tested in this research represents a form of clear information presentation and visualization that overcomes issues of jargon that degrades communication between healthcare providers and employees. (C) 2011 Elsevier B.V. All rights reserved. C1 [Caldwell, Barrett S.] Purdue Univ, Sch Ind Engn, W Lafayette, IN 47907 USA. [Douglas, Stephen E.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Caldwell, BS (reprint author), Purdue Univ, Sch Ind Engn, 315 N Grant St,228D, W Lafayette, IN 47907 USA. EM stephen.douglas@us.army.mil; bscaldwell@purdue.edu NR 18 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JUL PY 2011 VL 41 IS 4 SI SI BP 352 EP 359 DI 10.1016/j.ergon.2011.02.004 PG 8 WC Engineering, Industrial; Ergonomics SC Engineering GA 799RW UT WOS:000293304800004 ER PT J AU Bluman, JE Gandhi, FS AF Bluman, James E. Gandhi, Farhan S. TI Reducing Trailing Edge Flap Deflection Requirements in Primary Control with a Movable Horizontal Tail SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID SWASHPLATELESS HELICOPTER ROTOR AB Achieving primary control of helicopters through the use of trailing edge flaps holds significant promise in eliminating the swashplate and its related components. However, the predicted deflections that trailing edge flaps serving in this role must reach to achieve high-speed flight are currently beyond the stroke capability of existing smart material actuators that could be used. A method of reducing the required trailing edge flap deflections through fixed frame moments input via a movable horizontal tail is demonstrated to significantly reduce the required trailing edge flap deflections on a UH-60A helicopter. This study uses rigid blade flap-lag-torsion with aerodynamic trailing edge flaps, linear inflow, quasi-steady aerodynamics for the blade and flaps, fuselage aerodynamic properties modified with a movable horizontal tail, and a free flight trim procedure. A movable horizontal tail is demonstrated to reduce required cyclic trailing edge flap deflections on a UH-60A with rotating natural torsional frequency of 2.1/rev and pitch index of 20 degrees at an advance ratio of 0.30 to deflections within the deflection capability of current actuators (+/-5 degrees), and without a prohibitive vehicle attitude. C1 [Bluman, James E.] US Mil Acad, West Point, NY 10996 USA. [Gandhi, Farhan S.] Penn State Univ, University Pk, PA 16802 USA. RP Bluman, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. EM james.bluman@us.army.mil NR 23 TC 2 Z9 2 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2011 VL 56 IS 3 AR 032005 DI 10.4050/JAHS.56.032005 PG 12 WC Engineering, Aerospace SC Engineering GA 800TU UT WOS:000293391000006 ER PT J AU Hoyer, WJ Cerella, J Buchler, NG AF Hoyer, William J. Cerella, John Buchler, Norbou G. TI A Search-By-Clusters Model of Visual Search: Fits to Data From Younger and Older Adults SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES LA English DT Article DE Aging; Attention; Computational; Models; Eccentricity; Visual search ID FIELD-OF-VIEW; AGE-DIFFERENCES; SELECTIVE ATTENTION; CONJUNCTION SEARCH; SERIAL PROCESSES; EYE-MOVEMENTS; ECCENTRICITY; PARALLEL; OBJECTS; MEMORY AB Objectives. This study aims to specify the processing operations underlying age-related differences in the speed and accuracy of visual search in a mathematical model. Method. Eighteen older and 18 young adults searched for a predesignated target within 24-degree visual arrays containing distractors. Targets were systematically placed in regions that extended 2.5, 5.0, 7.5, and 10 degrees from center. Data were fitted to several versions of a mathematical model in which it was assumed that target search proceeds from the center fixation to peripheral areas in a succession of visual inspections of clusters until the target is located and that clusters can vary in size in response to search difficulty. Results. Eccentricity effects on latencies and errors were larger for older adults than for younger adults, especially in the hardest search condition. The best-fitting version of the "search-by-clusters" model accounted for an average of 98.4% and 95.4% of the variance in the young and older adults, respectively. The resulting time, accuracy, and cluster parameters behaved plausibly in each of the 36 data sets. Conclusions. A quantitative model that specified how individuals searched for targets in large arrays accurately predicted the search times and accuracies of younger and older adults. C1 [Hoyer, William J.; Cerella, John] Syracuse Univ, Dept Psychol, Syracuse, NY 13244 USA. [Buchler, Norbou G.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Hoyer, WJ (reprint author), Syracuse Univ, Dept Psychol, 430 Huntington Hall, Syracuse, NY 13244 USA. EM wjhoyer@syr.edu FU National Institute on Aging [AG11451] FX This research was supported by research grant AG11451 from the National Institute on Aging to W. J. Hoyer. NR 44 TC 1 Z9 1 U1 3 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1079-5014 J9 J GERONTOL B-PSYCHOL JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci. PD JUL PY 2011 VL 66 IS 4 BP 402 EP 410 DI 10.1093/geronb/gbr022 PG 9 WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology, Multidisciplinary SC Geriatrics & Gerontology; Psychology GA 798ZR UT WOS:000293251900002 PM 21459772 ER PT J AU VanderWerf, EA Mosher, SM Burt, MD Taylor, PE AF VanderWerf, Eric A. Mosher, Stephen M. Burt, Matthew D. Taylor, Philip E. TI Current Distribution and Abundance of O'ahu 'Elepaio (Chasiempis ibidis) in the Wai'anae Mountains SO PACIFIC SCIENCE LA English DT Article ID HAWAII ELEPAIO; NEW-ZEALAND; BIRDS; CONSERVATION; ISLANDS; HABITAT; RESTORATION; PREDATION AB The O'ahu 'Elepaio (Chasiempis ibidis) is an endangered forest bird endemic to O'ahu and has declined steadily during the past century. Current information.on distribution and abundance is needed to help assess the species status and identify areas where recovery efforts can be focused. We used spot-mapping methods to census O'ahu 'Elepaio in all suitable forest habitat in the Wai'anae Mountains from 2006 to 2010 and compared results with previous surveys from the 1990s. We detected a total of 300 O'ahu 'Elepaio, including 108 breeding pairs and 84 single males. The sex ratio was strongly male biased due to nest predation on females. Their distribution was extremely fragmented, and the only concentrations were in 'Ekahanui (38 pairs), Schofield Barracks West Range (40 pairs), and Palehua (15 pairs). We failed to detect 'Elepaio in many areas where they were observed in the 1990s. 'Elepaio have become more sparse in other areas, indicating that they are continuing to decline. Nest predation by alien black rats (Rattus rattus) and mosquito-borne diseases are the greatest threats. Rat control programs have helped reduce nest predation and stop declines in several areas, but only a fraction of remaining 'Elepaio benefit from active management and further declines can be expected unless rats are controlled on a larger scale. Alternative methods of rat control should be explored, and restoration of native trees that are less attractive to rats might provide safer nest sites and reduce the need for rat control. C1 [VanderWerf, Eric A.] Pacific Rim Conservat, Honolulu, HI 96822 USA. [Mosher, Stephen M.; Burt, Matthew D.; Taylor, Philip E.] Univ Hawaii Manoa, Pacific Cooperat Studies Unit, Dept Bot, Honolulu, HI 96822 USA. [Mosher, Stephen M.; Burt, Matthew D.; Taylor, Philip E.] Nat Resources IMPC HI PWE, Dept Army USAG HI, Directorate Publ Works, Environm Div, Schofield Barracks, HI 96857 USA. RP VanderWerf, EA (reprint author), Pacific Rim Conservat, 3038 Oahu Ave, Honolulu, HI 96822 USA. EM eric@pacificrimconservation.com FU U.S. Army Hawai'i Garrison; Hawai'i Division of Forestry and Wildlife; Nature Conservancy of Hawai'i FX This work was funded by the U.S. Army Hawai'i Garrison, the Hawai'i Division of Forestry and Wildlife, and The Nature Conservancy of Hawai'i. Manuscript accepted 14 September 2010. NR 37 TC 2 Z9 2 U1 1 U2 6 PU UNIV HAWAII PRESS PI HONOLULU PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA SN 0030-8870 J9 PAC SCI JI Pac. Sci. PD JUL PY 2011 VL 65 IS 3 BP 311 EP 319 DI 10.2984/65.3.311 PG 9 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA 800OM UT WOS:000293371300003 ER PT J AU Kannarpady, GK Khedir, KR Ishihara, H Woo, J Shin, OD Trigwell, S Ryerson, C Biris, AS AF Kannarpady, Ganesh K. Khedir, Khedir R. Ishihara, Hidetaka Woo, Justin Shin, Olumide D. Trigwell, Steve Ryerson, Charles Biris, Alexandru S. TI Controlled Growth of Self-Organized Hexagonal Arrays of Metallic Nanorods Using Template-Assisted Glancing Angle Deposition for Superhydrophobic Applications SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE Metallic nanorods; GLAD deposition; Template assisted growth; Hexagonal self-organization; superhydrophobicity ID SCULPTURED THIN-FILMS; FABRICATION; SURFACES; NANOSTRUCTURES; LITHOGRAPHY; WATER AB The fabrication of controlled, self-organized, highly ordered tungsten and aluminum nanorods was accomplished via the aluminum lattice template-assisted glancing angle sputtering technique. The typical growth mechanism of traditional glancing angle deposition technique was biased by self-organized aluminum lattice seeds resulting in superior quality nanorods in terms of size control, distribution, and long range order. The morphology, size, and distribution of the nanorods were highly controlled by the characteristics of the template seeds indicating the ability to obtain metallic nanorods with tunable distributions and morphologies that can be grown to suit a particular application. Water wettability of hexagonally arranged tungsten and aluminum nanorods was studied after modifying their surface with 5 nm of Teflon AF 2400, as an example, to exhibit the significance of such a controlled growth of metallic nanorods. This facile and scalable approach to generate nano seeds to guide GLAD, with nano seeds fabricated by anodic oxidization of aluminum followed by chemical etching, for the growth of highly ordered nanorods could have significant impact in a wide range of applications such as anti-icing coating, sensors, super capacitors, and solar cells. C1 [Kannarpady, Ganesh K.; Khedir, Khedir R.; Ishihara, Hidetaka; Woo, Justin; Shin, Olumide D.; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Trigwell, Steve] ASRC Aerosp, Orlando, FL 32899 USA. [Ryerson, Charles] Ctr US Army Corps Engineers, Terr & Cryospher Sci Branch, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Kannarpady, GK (reprint author), Univ Arkansas, Nanotechnol Ctr, 2801 S Univ Ave, Little Rock, AR 72204 USA. EM gkkannarpady@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU U.S. Army [W912HZ-09-02-0008]; Arkansas Science & Technology Authority [08-CAT-03]; Department of Energy [DE-FG36-06GO86072]; National Science Foundation [NSF/EPS-1003970] FX Financial support from U.S. Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008), Arkansas Science & Technology Authority (Grant # 08-CAT-03), Department of Energy (DE-FG36-06GO86072), and National Science Foundation (NSF/EPS-1003970) is greatly appreciated. The editorial assistance of Dr. Marinelle Ringer is also acknowledged. NR 53 TC 21 Z9 22 U1 2 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JUL PY 2011 VL 3 IS 7 BP 2332 EP 2340 DI 10.1021/am200251n PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 798IO UT WOS:000293196800027 PM 21644535 ER PT J AU Jacoby, G Keville, K AF Jacoby, Grant Keville, Kurt TI To Support and Defend: A Spirited Engineering Competition SO IEEE PERVASIVE COMPUTING LA English DT Editorial Material C1 [Jacoby, Grant] USA, Washington, DC 20310 USA. [Jacoby, Grant] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Jacoby, G (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1268 J9 IEEE PERVAS COMPUT JI IEEE Pervasive Comput. PD JUL-SEP PY 2011 VL 10 IS 3 BP 84 EP 88 PG 5 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 797RV UT WOS:000293146600012 ER PT J AU Vandock, KP Emerson, DJ McLendon, KE Rassman, AA AF Vandock, Kurt P. Emerson, Darby J. McLendon, Kathryn E. Rassman, Alyssa A. TI Phospholipid Dependence of the Reversible, Energy-Linked, Mitochondrial Transhydrogenase in Manduca sexta SO JOURNAL OF MEMBRANE BIOLOGY LA English DT Article DE Energy-linked transhydrogenase; Mitochondria; NADPH; Phospholipid dependence ID NICOTINAMIDE-NUCLEOTIDE TRANSHYDROGENASE; ADULT HYMENOLEPIS-DIMINUTA; LARVAL-PUPAL DEVELOPMENT; TOBACCO HORNWORM; STEROID HYDROXYLASE; MIDGUT AB Midgut mitochondria from fifth larval instar Manduca sexta exhibit a membrane-associated transhydrogenase that catalyzes hydride ion transfer between NADP(H) and NAD(H). The NADPH-forming transhydrogenations occur as nonenergy- and energy-linked activities. The energy-linked activities couple with electron transport-dependent utilization of NADH/succinate, or with Mg(2+)-dependent ATPase. These energy-linked transhydrogenations have been shown to be physiologically and developmentally significant with respect to insect larval/pupal maturation. In the present study, isolated mitochondrial membranes were lyophilized and subjected to organic solvent or phospholipase treatments. Acetone extraction and addition of Phospholipase A(2) proved to be effective inhibitors of the insect transhydrogenase. Liberation of phospholipids was reflected by measured phosphorous release. Addition of phospholipids to organic solvent- and phospholipase-treated membranes was without effect. Employing a partially lipid-depleted preparation, phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine were reintroduced and transhydrogenase activity assessed. Of the phospholipids tested, only phosphatidylcholine significantly stimulated transhydrogenase activity. The results of this study suggest a phospholipid dependence of the M. sexta mitochondrial transhydrogenase. C1 [Vandock, Kurt P.; Emerson, Darby J.; McLendon, Kathryn E.; Rassman, Alyssa A.] Houghton Coll, Dept Biol, Paine Ctr Sci 307, Houghton, NY 14744 USA. [Vandock, Kurt P.] USA, USA Reserve, Reserve Med Command APMC, Forest Pk, GA 30297 USA. RP Vandock, KP (reprint author), Houghton Coll, Dept Biol, Paine Ctr Sci 307, Houghton, NY 14744 USA. EM kurt.vandock@houghton.edu FU Houghton College; United States Army Reserve, APMC FX This study was supported in part by Houghton College and the United States Army Reserve, APMC (KPV). The assistance of Dr. Martin Mitchell, Edinboro University of Pennsylvania, for his review is gratefully acknowledged. NR 24 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2631 J9 J MEMBRANE BIOL JI J. Membr. Biol. PD JUL PY 2011 VL 242 IS 2 BP 89 EP 94 DI 10.1007/s00232-011-9379-1 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Physiology SC Biochemistry & Molecular Biology; Cell Biology; Physiology GA 797RB UT WOS:000293144200004 PM 21732010 ER PT J AU Pine, SR Mechanic, LE Enewold, L Chaturvedi, AK Katki, HA Zheng, YL Bowman, ED Engels, EA Caporaso, NE Harris, CC AF Pine, Sharon R. Mechanic, Leah E. Enewold, Lindsey Chaturvedi, Anil K. Katki, Hormuzd A. Zheng, Yun-Ling Bowman, Elise D. Engels, Eric A. Caporaso, Neil E. Harris, Curtis C. TI Increased Levels of Circulating Interleukin 6, Interleukin 8, C-Reactive Protein, and Risk of Lung Cancer SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID SERUM-LEVELS; AFRICAN-AMERICANS; CARCINOMA-CELLS; SURVIVAL; INFLAMMATION; PROGRESSION; EXPRESSION; POPULATION; SENESCENCE; PROGNOSIS AB Background Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking. Methods Associations between serum interleukin 6 (IL-6) and interleukin 8 (IL-8) levels and lung cancer were analyzed among 270 case patients and 296 control subjects participating in the National Cancer Institute-Maryland (NCI-MD) case-control study. Results were validated in 532 case patients and 595 control subjects in a nested case-control study within the prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Association with C-reactive protein (CRP), a systemic inflammation biomarker, was also analyzed. Associations between biomarkers and lung cancer were estimated using logistic regression models adjusted for smoking, stage, histology, age, and sex. The 10-year standardized absolute risks of lung cancer were estimated using a weighted Cox regression model. Results Serum IL-6 and IL-8 levels in the highest quartile were associated with lung cancer in the NCI-MD study (IL-6, odds ratio [OR] = 3.29, 95% confidence interval [CI] = 1.88 to 5.77; IL-8, OR = 2.06, 95% CI = 1.19 to 3.57) and with lung cancer risk in the PLCO study (IL-6, OR = 1.48, 95% CI = 1.04 to 2.10; IL-8, OR = 1.57, 95% CI = 1.10 to 2.24), compared with the lowest quartile. In the PLCO study, increased IL-6 levels were only associated with lung cancer diagnosed within 2 years of blood collection, whereas increased IL-8 levels were associated with lung cancer diagnosed more than 2 years after blood collection (OR = 1.57, 95% CI = 1.15 to 2.13). The 10-year standardized absolute risks of lung cancer in the PLCO study were highest among current smokers with high IL-8 and CRP levels (absolute risk = 8.01%, 95% CI = 5.77% to 11.05%). Conclusions Although increased levels of both serum IL-6 and IL-8 are associated with lung cancer, only IL-8 levels are associated with lung cancer risk several years before diagnosis. Combination of IL-8 and CRP are more robust biomarkers than either marker alone in predicting subsequent lung cancer. J Natl Cancer Inst 2011;103:1112-1122 C1 [Pine, Sharon R.; Mechanic, Leah E.; Bowman, Elise D.; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA. [Pine, Sharon R.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Div Med Oncol,Canc Inst New Jersey, New Brunswick, NJ 08903 USA. [Mechanic, Leah E.] NCI, Epidemiol & Genet Res Program, Host Susceptibil Factors Branch, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Enewold, Lindsey] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Enewold, Lindsey] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Chaturvedi, Anil K.; Engels, Eric A.] NCI, Infect & Immunoepidemiol Branch, Rockville, MD USA. [Katki, Hormuzd A.] NCI, Biostat Branch, Rockville, MD USA. [Caporaso, Neil E.] NCI, Genet Epidemiol Branch, Rockville, MD USA. [Chaturvedi, Anil K.; Engels, Eric A.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. [Zheng, Yun-Ling] Georgetown Univ, Lombardi Comprehens Canc Ctr, Biomarkers Epidemiol Program, Washington, DC USA. RP Harris, CC (reprint author), NCI, Human Carcinogenesis Lab, Ctr Canc Res, 37 Convent Dr,Rm 3068A,MSC 4258, Bethesda, MD 20892 USA. EM curtis_harris@nih.gov RI Katki, Hormuzd/B-4003-2015; Chaturvedi, Anil/J-2024-2015 OI Chaturvedi, Anil/0000-0003-2696-8899 FU National Institutes of Health, National Cancer Institute, Center for Cancer Research FX Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. NR 42 TC 120 Z9 123 U1 2 U2 14 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD JUL PY 2011 VL 103 IS 14 BP 1112 EP 1122 DI 10.1093/jnci/djr216 PG 11 WC Oncology SC Oncology GA 796BB UT WOS:000293024100010 PM 21685357 ER PT J AU Yu, CG Zavaljevski, N Desai, V Reifman, J AF Yu, Chenggang Zavaljevski, Nela Desai, Valmik Reifman, Jaques TI QuartetS: a fast and accurate algorithm for large-scale orthology detection SO NUCLEIC ACIDS RESEARCH LA English DT Article ID PHYLOGENETIC TREES; EUKARYOTIC GENOMES; GENE DUPLICATION; IDENTIFICATION; PARALOGS; DATABASE; PREDICTION; PROTEOMES; INFERENCE; EVOLUTION AB The unparalleled growth in the availability of genomic data offers both a challenge to develop orthology detection methods that are simultaneously accurate and high throughput and an opportunity to improve orthology detection by leveraging evolutionary evidence in the accumulated sequenced genomes. Here, we report a novel orthology detection method, termed QuartetS, that exploits evolutionary evidence in a computationally efficient manner. Based on the well-established evolutionary concept that gene duplication events can be used to discriminate homologous genes, QuartetS uses an approximate phylogenetic analysis of quartet gene trees to infer the occurrence of duplication events and discriminate paralogous from orthologous genes. We used function- and phylogeny-based metrics to perform a large-scale, systematic comparison of the orthology predictions of QuartetS with those of four other methods [bi-directional best hit (BBH), outgroup, OMA and QuartetS-C (QuartetS followed by clustering)], involving 624 bacterial genomes and > 2 million genes. We found that QuartetS slightly, but consistently, outperformed the highly specific OMA method and that, while consuming only 0.5% additional computational time, QuartetS predicted 50% more orthologs with a 50% lower false positive rate than the widely used BBH method. We conclude that, for large-scale phylogenetic and functional analysis, QuartetS and QuartetS-C should be preferred, respectively, in applications where high accuracy and high throughput are required. C1 [Yu, Chenggang; Zavaljevski, Nela; Desai, Valmik; Reifman, Jaques] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM Jaques.Reifman@us.army.mil FU U.S. DoD under the High Performance Computing Software Applications Institutes Initiative FX This work was supported by the U.S. DoD High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes Initiative. Funding for open access charge is the same as the funding for the performed research. NR 26 TC 14 Z9 14 U1 1 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD JUL PY 2011 VL 39 IS 13 AR e88 DI 10.1093/nar/gkr308 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 795ZV UT WOS:000293020000005 PM 21572104 ER PT J AU Ratches, JA AF Ratches, James A. TI Review of current aided/automatic target acquisition technology for military target acquisition tasks SO OPTICAL ENGINEERING LA English DT Review DE Aided and automatic target recognition; Aided and automatic target recognition performances; military target acquisitions; receiver operator characteristics; clutter; target variability ID INFRARED-SENSORS; RECOGNITION; PERFORMANCE; SYSTEMS; IMAGERY; MODEL; WAVE AB Aided and automatic target recognition (Ai/ATR) capability is a critical technology needed by the military services for modern combat. However, the current level of performance that is available is largely deficient compared to the requirements. This is largely due to the difficulty of acquiring targets in realistic environments but has also been due to the difficulty in getting new concepts from, for example, the academic community, due to limitations for distribution of classified data. The difficulty of the performance required has limited the fulfillment of the promise that is so anticipated by the war fighter. We review the metrics, imagery data bases, and sensors associated with Ai/ATR performance and suggest possible technical approaches that could enable new advancements in military-relevant performance. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3601879] C1 USA, Res Lab, Adelphi, MD 20817 USA. RP Ratches, JA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20817 USA. EM jim.ratches@us.army.mil NR 46 TC 12 Z9 14 U1 1 U2 10 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUL PY 2011 VL 50 IS 7 AR 072001 DI 10.1117/1.3601879 PG 8 WC Optics SC Optics GA 797XZ UT WOS:000293164700018 ER PT J AU Cao, XY Olk, DC Chappell, M Cambardella, CA Miller, LF Mao, JD AF Cao, Xiaoyan Olk, Daniel C. Chappell, Mark Cambardella, Cynthia A. Miller, Lesley F. Mao, Jingdong TI Solid-State NMR Analysis of Soil Organic Matter Fractions from Integrated Physical-Chemical Extraction SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID CONVENTIONALLY MANAGED SOILS; HUMIC-ACID FRACTIONS; MAGNETIC-RESONANCE; NITROGEN DYNAMICS; CARBON DYNAMICS; C-13; SPECTROSCOPY; HUMIFICATION; SUBSTANCES; POOLS AB Fractions of soil organic matter (SOM) were extracted by an integrated physical-chemical procedure and their chemical natures were characterized through (13)C nuclear magnetic resonance (NMR) spectroscopy. For the 0- to 5-cm depth of a corn (Zea mays L.)-soybean [Glycine max. (L.) Merr.] soil in Iowa, we extracted in sequence the light fraction, two size fractions of particulate organic matter (POM), and two NaOH-extractable humic acid fractions based on their binding to soil Ca(2+): the unbound mobile humic acid fraction and the calcium humate fraction. Whole SOM was obtained by dissolving the soil mineral component through HF washes. All samples were analyzed by advanced (13)C NMR techniques, including quantitative direct polarization/magic angle spinning, spectral-editing techniques, and two-dimensional (1)H-(13)C heteronuclear correlation NMR. The NMR spectra were comparable for the light fraction and two POM fractions and were dominated by carbohydrates and to a lesser extent lignins or their residues, with appreciable proteins or peptides. By contrast, spectra of the two humic fractions were dominated by aromatic C and COO/N-C=O groups, with smaller proportions of carbohydrates and NCH/OCH(3) groups, indicative of more humified material. This trend was yet more pronounced in the calcium humate fraction. The spectrum for whole SOM had signals intermediate between these two groups of SOM fractions, suggesting contributions from both groups. Our results for this soil suggest that either chemical or physical fractions alone will partially represent whole SOM, and their integrated use is likely to provide greater insight into SOM structure and possibly function, depending on the research issue. C1 [Cao, Xiaoyan; Mao, Jingdong] Old Dominion Univ, Dep Chem & Biochem, Norfolk, VA 23529 USA. [Olk, Daniel C.; Cambardella, Cynthia A.] ARS, USDA, Natl Lab Agr & Environm, Ames, IA 50011 USA. [Chappell, Mark; Miller, Lesley F.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dep Chem & Biochem, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [EAR-0843996, CBET-0853950, DEB-1057472]; Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust FX This work was supported by the National Science Foundation (EAR-0843996, CBET-0853950, and DEB-1057472) and the Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust. We thank Mr. Terry Grimard for his careful extractions of the soil organic matter fractions and Ms. Jody Ohmacht for her assistance with the extractions. NR 41 TC 17 Z9 18 U1 4 U2 51 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 0361-5995 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD JUL PY 2011 VL 75 IS 4 BP 1374 EP 1384 DI 10.2136/sssaj2010.0382 PG 11 WC Soil Science SC Agriculture GA 796TW UT WOS:000293076400018 ER PT J AU Antonic, V Mittermayr, R Schaden, W Stojadinovic, A AF Antonic, Vlado Mittermayr, Rainer Schaden, Wolfgang Stojadinovic, Alexander TI Evidence Supporting Extracorporeal Shockwave Therapy for Acute and Chronic Soft Tissue Wounds SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE LA English DT Review ID ENDOTHELIAL GROWTH-FACTOR; WAVE THERAPY; HYPERBARIC-OXYGEN; GENE-EXPRESSION; ANGIOGENESIS; ULCERS; CELLS; BONE; RECRUITMENT; MANAGEMENT AB Soft tissue wound healing is a complex and well-orchestrated sequence of events on multiple biological levels involving systemic, cellular, and molecular signals. The physiological process of wound healing leads to full tissue repair and regeneration with nearly complete restoration of tissue integrity and functionality. Wounds, particularly among the elderly population, can show delayed or disturbed healing; however, delayed or disturbed healing is also evident in patients with comorbidities such as diabetes, atherosclerosis, venous/arterial insufficiency, reduced mobility due to chronic infirmity, and hypercholesterolemia. Chronic wounds consist of a wide range of inflammatory and degenerative conditions of the musculoskeletal system. Management of chronic, difficult to heal, or non-healing soft tissue wounds requires a multidisciplinary approach. Often these treatment options have inconsistent and irregular outcomes. Poor response or failure to conservative treatments places a substantial burden on patients, their families, the healthcare system, and society in general. Therefore, the development of a new, effective method of treatment to improve healing of problematic wounds and reduce treatment-related costs is extremely valuable; ne such therapy is Extracorporeal Shockwave Therapy (ESWT). ESWT acts through mechanotransduction, which produces therapeutic benefits through complex biological pathways including neovascularization and tissue regeneration in the therapeutic target. Published data thus far suggest that the application of ESWT for soft tissue indications is safe, reliable, cost-effective, and clinically efficacious. The exact biological effects of ESWT on human cells are not completely understood, but are currently undergoing further study. The aim of this review is to provide a general overview of shockwave therapy and its role in the treatment of acute and chronic soft tissue wounds. C1 [Antonic, Vlado; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. [Antonic, Vlado] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Mittermayr, Rainer] Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria. [Mittermayr, Rainer; Schaden, Wolfgang] AUVA Trauma Ctr, Vienna, Austria. RP Antonic, V (reprint author), Diagnost & Translat Res Ctr, Combat Wound Initiat Program, 401 Profess Dr, Gaithersburg, MD 20879 USA. EM vlado_antonic@hotmail.com FU Combat Wound Initiative Program FX The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of the Army the Department of Defense, or the United States Government. This effort was supported by the congressionally funded Combat Wound Initiative Program. One of the authors is a military service member (or employee of the US Government). This work was prepared as part of official duties. Title 17 U.S.C. 105 provides the "Copyright protection under this title is not available for any. work of the United States Government." Title 17 U.S.C. 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. NR 54 TC 3 Z9 3 U1 1 U2 11 PU H M P COMMUNICATIONS PI MALVERN PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA SN 1044-7946 EI 1943-2704 J9 WOUNDS JI Wounds-Compend. Clin. Res. Pract. PD JUL PY 2011 VL 23 IS 7 BP 204 EP 215 PG 12 WC Dermatology; Surgery SC Dermatology; Surgery GA 799TF UT WOS:000293308300006 PM 25879174 ER PT J AU Seay, JF Van Emmerik, REA Hamill, J AF Seay, Joseph F. Van Emmerik, Richard E. A. Hamill, Joseph TI Low back pain status affects pelvis-trunk coordination and variability during walking and running SO CLINICAL BIOMECHANICS LA English DT Article DE Low back pain; Coordination; Coordination variability; Walking; Running; Continuous relative phase; Range of motion; Pelvis; Trunk ID DYNAMICAL-SYSTEMS PERSPECTIVE; CONTINUOUS RELATIVE PHASE; STABILITY; HISTORY; LOCOMOTION; INJURIES; SPEED AB Background: The purpose of this study was to compare pelvis-trunk coordination and coordination variability over a range of walking and running speeds between three groups of runners; runners with low to moderate low back pain; runners who had recovered from a single bout of acute low back pain; and runners who had never experienced any symptoms of low back pain. Methods: Pelvis and trunk kinematic data were collected as speed was systematically increased on a treadmill. Coordination between pelvis and trunk in all three planes of motion was measured using continuous relative phase, and coordination variability was defined as the standard deviation of this measure. Findings: Oswestry Disability Index indicated the low back pain group was high functioning (mean 7.9% out of 100%). During walking, frontal plane coordination was more in-phase for the low back pain group compared to controls (P=0.029), with the resolved group showing an intermediate coordination pattern (P=0.064). During running, both low back pain (P=0.021) and resolved (P=0.025) groups showed more in-phase coordination in the transverse plane than the control group. The low back pain group also showed reduced transverse plane coordination variability compared to controls (P=0.022). Interpretation: Coordination and coordination variability results showed a continuum of responses between our three groups. Taken together, the data lend insight into increased injury risk and performance deficits associated with even one bout of low back pain, and suggest that clinicians need to look beyond the resolution of pain when prescribing rehabilitation for low back pain. (C) 2010 Published by Elsevier Ltd. C1 [Seay, Joseph F.; Van Emmerik, Richard E. A.; Hamill, Joseph] Univ Massachusetts Amherst, Dept Kinesiol, Amherst, MA USA. RP Seay, JF (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM joseph.seay@gmail.com NR 28 TC 42 Z9 42 U1 4 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 J9 CLIN BIOMECH JI Clin. Biomech. PD JUL PY 2011 VL 26 IS 6 BP 572 EP 578 DI 10.1016/j.clinbiomech.2010.11.012 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA 795BB UT WOS:000292945400006 PM 21536356 ER PT J AU Morang, A Mohr, MC Forgette, CM AF Morang, Andrew Mohr, Michael C. Forgette, Craig M. TI Longshore Sediment Movement and Supply along the US Shoreline of Lake Erie SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Bluff retreat; shoreline change; harbors; glacial till; harbor; jetty; shore protection; sand ID PROTECTION STRUCTURES AB To establish existing conditions for dredge material beneficial use projects and to help implement principles of Regional Sediment Management (RSM) into projects and studies, this paper is an assessment of sediment sources and sinks, physical processes, and longshore sediment transport along the west and south shore of Lake Erie. This summary compiles information from a widely scattered technical literature and synthesizes the results in preparation for development of a sediment budget. The U.S. shore of Lake Erie has 28 river or harbor mouths protected with jetties and structures, of which 16 are Federal navigation projects. Much of the sediment management since the mid-1800s has revolved around providing safe navigation, maintaining depth in navigation channels, and disposing of the dredged material. Sediment sources include material brought down the rivers (often fine-grained); industrial dumping and runoff from sewers, gravel, sand, and clay eroded from glacial till bluffs and clay banks; sediment created in situ from bedrock bluff weathering (primarily from shale); and limited supply from lake bed lowering and offshore outcrops. Losses include wave- and ice-induced transport to deep water, sediment trapped in fillets at harbor jetties, sediment dredged from harbor entrance channel and placed in confined disposal facilities (CDFs) or placed offshore, bluff armoring, and (formerly) beach mining. Today, the south shore of Lake Erie is severely sand-starved compared with conditions that existed 200 years ago. The lack of available sediment is largely due to man-made causes. As the shore developed and became urbanized after the mid-1800s, residents, industries, and municipalities attempted to arrest bluff erosion with the use of structures and vegetation. Now the U.S. shoreline of Lake Erie is almost 83% protected, a larger percentage than any ocean coast except in urban areas. It means that little sediment exchange occurs compared with predeveloped conditions, which, in turn, means that managers must recycle and reuse existing sediment to maintain recreation beaches. Managing sediment to benefit a region sustainably potentially will save money, allow use of natural processes to solve engineering problems, and improve recreation resources and natural habitat. C1 [Morang, Andrew] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Mohr, Michael C.; Forgette, Craig M.] US Army Engineer Dist, Buffalo, NY 14207 USA. RP Morang, A (reprint author), USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Andrew.Morang@usace.army.mil NR 62 TC 6 Z9 6 U1 1 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2011 VL 27 IS 4 BP 619 EP 635 DI 10.2112/JCOASTRES-D-09-00145.1 PG 17 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 795DL UT WOS:000292951600003 ER PT J AU Houston, JR Dean, RG AF Houston, J. R. Dean, R. G. TI Reply to: Rahmstorf, S. and Vermeer, M., 2011. Discussion of: Houston, J.R. and Dean, R.G., 2011. Sea-Level Acceleration Based on U.S. Tide Gauges and Extensions of Previous Global-Gauge Analyses. Journal of Coastal Research, 27(3), 409-417 SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material ID RISE C1 [Houston, J. R.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, R. G.] Univ Florida, Dept Civil & Coastal Civil Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil; dean@coastal.ufl.edu NR 11 TC 3 Z9 3 U1 1 U2 3 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2011 VL 27 IS 4 BP 788 EP 790 DI 10.2112/JCOASTRES-D-11A-00008.1 PG 3 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 795DL UT WOS:000292951600019 ER PT J AU Yao, CP Wei, G Lu, XCM Yang, WH Tortella, FC Dave, JR AF Yao, Changping Wei, Guo Lu, X. -C. May Yang, Weihong Tortella, Frank C. Dave, Jitendra R. TI Selective Brain Cooling in Rats Ameliorates Intracerebral Hemorrhage and Edema Caused by Penetrating Brain Injury: Possible Involvement of Heme Oxygenase-1 Expression SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; edema; heme; heme oxygenase-1 (HO-1); intracerebral hemorrhage; penetrating ballistic-like brain injury; selective brain cooling ID MODERATE HYPOTHERMIA; OXIDATIVE INJURY; GENE-EXPRESSION; CARBON-MONOXIDE; NEUROPROTECTION; INDUCTION; BILIRUBIN; ASTROGLIA; STRESS; MODEL AB Brain edema formation associated with trauma-induced intracerebral hemorrhage (ICH) is a clinical complication with high mortality. Studies have shown that heme oxygenase-1 (HO-1) plays an important role in ICH-induced brain edema. In order to understand the role of HO-1 in the protective effect of selective brain cooling (SBC), we investigated the time course of HO-1 changes following penetrating ballistic-like brain injury (PBBI) in rats. Samples were collected from injured and control animals at 6, 24, 48, and 72 h, and 7 days post-injury to evaluate HO-1 expression, heme concentration, brain water content, and immunohistochemistry (IHC). Following a 10% frontal PBBI, HO-1 mRNA and protein was increased at all time points studied, reaching maximum expression levels at 24-48 h post-injury. An increase in the heme concentration and the development of brain edema coincided with the upregulation of HO-1 mRNA and protein during the 7-day post-injury period. SBC significantly decreased PBBI-induced heme concentration, attenuated HO-1 upregulation, and concomitantly reduced brain water content. These results suggest that the neuroprotective effects of SBC may be partially mediated by reducing the heme accumulation, which reduced injury-mediated upregulation of HO-1, and in turn ameliorated edema formation. Collectively, these results suggest a potential value of HO-1 as a diagnostic and/or therapeutic biomarker in hemorrhagic brain injury. C1 [Yao, Changping; Wei, Guo; Lu, X. -C. May; Yang, Weihong; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jit.dave@amedd.army.mil RI Dave, Jitendra/A-8940-2011 NR 57 TC 7 Z9 8 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2011 VL 28 IS 7 BP 1237 EP 1245 DI 10.1089/neu.2010.1678 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 794BL UT WOS:000292869600012 PM 21463155 ER PT J AU Steele, SR Chen, SL Stojadinovic, A Nissan, A Zhu, KM Peoples, GE Bilchik, A AF Steele, Scott R. Chen, Steven L. Stojadinovic, Alexander Nissan, Aviram Zhu, Kangmin Peoples, George E. Bilchik, Anton TI The Impact of Age on Quality Measure Adherence in Colon Cancer SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article; Proceedings Paper CT 118th Scientific Session of the Western-Surgical-Association CY NOV, 2010 CL Chicago, IL SP Western Surg Assoc ID LYMPH-NODE EVALUATION; ADJUVANT CHEMOTHERAPY USE; COLORECTAL-CANCER; STAGE-III; ELDERLY-PATIENTS; TOTAL NUMBER; RISK-FACTORS; SURVIVAL; RETRIEVAL; SPECIMENS AB BACKGROUND: Recently lymph node yield (LNY) has been endorsed as a quality measure of colon cancer resection adequacy. It is unclear whether this measure is relevant to all ages. We hypothesized that total lymph node yield (LNY) is negatively correlated with increasing age and overall survival (OS). STUDY DESIGN: The Surveillance, Epidemiology and End Results (SEER) database was queried for all nonmetastatic colon cancer patients diagnosed from 1992 to 2004 (n = 101,767), grouped by age (<40, 41 to 45, 46 to 50, and in 5-year increments until 86+ years). Proportions of patients meeting the 12 LNY minimum criterion were determined in each age group and analyzed with multivariate linear regression adjusting for demographics and American Joint Committee on Cancer (AJCC) 6(th) Edition stage. OS comparisons in each age category were based on the guideline of 12 LNY. RESULTS: Mean LNY decreased with increasing age (18.7 vs 11.4 nodes/patient, youngest vs oldest group, p < 0.001). The proportion of patients meeting the 12 LNY criterion also declined with each incremental age group (61.9% vs 35.2% compliance, youngest vs oldest, p < 0.001). Multivariate regression demonstrated a negative effect of each additional year in age and log (LNY) with coefficient of -0.003 (95% CI -0.003 to -0.002). When stratified by age and nodal yield using the 12 LNY criterion, OS was lower for all age groups in stage II colon cancer with less than 12 LNY, and each age group over 60 years with less than 12 LNY for stage III colon cancer (p < 0.05). CONCLUSIONS: Every attempt to adhere to proper oncologic principles should be made at the time of colon cancer resection regardless of age. The prognostic significance of the 12 LN minimum criterion should be applied even to elderly colon cancer patients. (J Am Coll Surg 2011; 213: 95-105. (C) 2011 by the American College of Surgeons) C1 [Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Div Colorectal Surg, Tacoma, WA 98431 USA. [Chen, Steven L.] Univ Calif Davis, Dept Surg, Div Surg Oncol, Sacramento, CA 95817 USA. [Stojadinovic, Alexander; Zhu, Kangmin; Peoples, George E.; Bilchik, Anton] US Mil, Inst Canc, Clin Trials Grp, Washington, DC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Jerusalem, Israel. [Bilchik, Anton] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Bilchik, Anton] Calif Oncol Res Inst, Los Angeles, CA USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Div Surg Oncol, San Antonio, TX USA. RP Steele, SR (reprint author), 9606 Piperhill Dr SE, Olympia, WA 98513 USA. EM Harkersteele@mac.com FU NCI NIH HHS [2R01CA090848, R01 CA090848, R01 CA090848-01] NR 44 TC 20 Z9 20 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JUL PY 2011 VL 213 IS 1 BP 95 EP 103 DI 10.1016/j.jamcollsurg.2011.04.013 PG 9 WC Surgery SC Surgery GA 794SU UT WOS:000292922400021 PM 21601492 ER PT J AU Foster, TN Farquharson, ER AF Foster, T. Noble Farquharson, Eric R. TI Assessment Procedures for Skills-Based MBA Courses Adapted from the US Army Reserve Officer Training Corps Leadership Development Program SO NEGOTIATION JOURNAL LA English DT Article DE negotiation; negotiation training; pedagogy; assessment; grading; learning outcomes ID NEGOTIATION SKILLS; VIDEO AB Measuring student progress toward the achievement of learning outcomes in negotiation skills courses is a difficult task. Measuring the effectiveness of the delivery of course instruction can be equally challenging. This article proposes some answers to these questions: How can student performance in skills such as negotiation, leadership, and teamwork (sometimes referred to as "soft skills") be effectively measured and accurately evaluated? What standards can be used to determine whether student performance is superior, adequate, or inferior? How can teaching effectiveness be evaluated to determine whether students are receiving the instruction necessary to achieve the course learning objectives? This article describes how the authors collaborated on an adaptation of the assessment processes used in the U.S. Army Reserve Officer Training Corps (ROTC) cadet Leadership Development Program for use in an MBA course on negotiation skills. We report on a pilot effort that has demonstrated that the ROTC-style leadership assessment process can be successfully adapted for use in a graduate course on negotiation and that it provides useful means for evaluating both individual student performance and overall course effectiveness. While our work involved a negotiation course, we suggest that the process could be adapted for use in other skills-oriented courses such as leadership. C1 [Foster, T. Noble] Seattle Univ, Albers Sch Business & Econ, Seattle, WA 98122 USA. [Farquharson, Eric R.] Seattle Univ, Mil Sci Dept, Seattle, WA 98122 USA. [Farquharson, Eric R.] USA, Washington, DC 20301 USA. RP Foster, TN (reprint author), Seattle Univ, Albers Sch Business & Econ, Seattle, WA 98122 USA. EM tfoster@seattleu.edu; farquhae@seattleu.edu NR 21 TC 1 Z9 1 U1 1 U2 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0748-4526 J9 NEGOTIATION J JI Negot. J. PD JUL PY 2011 VL 27 IS 3 BP 367 EP 386 DI 10.1111/j.1571-9979.2011.00312.x PG 20 WC Management; Social Sciences, Interdisciplinary SC Business & Economics; Social Sciences - Other Topics GA 793SS UT WOS:000292844000008 ER PT J AU Bradfute, SB Bavari, S AF Bradfute, Steven B. Bavari, Sina TI Correlates of Immunity to Filovirus Infection SO VIRUSES-BASEL LA English DT Review DE filovirus; ebola; marburg; immunity ID EBOLA-VIRUS INFECTION; MARBURG HEMORRHAGIC-FEVER; PROTECTS NONHUMAN-PRIMATES; DOUBLE-STRANDED-RNA; T-CELL RESPONSES; ATTENUATED RECOMBINANT VACCINE; MOUSE MODEL; DENDRITIC CELLS; POSTEXPOSURE PROTECTION; VP35 PROTEIN AB Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment. C1 [Bradfute, Steven B.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM steven.bradfute@us.army.mil; sina.bavari@amedd.army.mil FU Joint Science and Technology Office from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA) [1.1C0003_08_RD_B] FX We thank Jens H. Kuhn and John M. Dye, Jr., for critically reviewing the manuscript. This work was supported in part by the Joint Science and Technology Office program project number 1.1C0003_08_RD_B from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA) (SB); and in part by an appointment to the Postgraduate Research Participation Program at the US Army Medical Research Institute for Infectious Disease administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and US Army Medical Research and Materiel Command (SBB). The content of this publication does not necessarily reflect the views or policies of the US Department of Defense or the US Department of the Army. NR 125 TC 15 Z9 15 U1 0 U2 9 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD JUL PY 2011 VL 3 IS 7 BP 982 EP 1000 DI 10.3390/v3070982 PG 19 WC Virology SC Virology GA 796RQ UT WOS:000293070000002 PM 21994766 ER PT J AU Delaney, DK Pater, LL Carlile, LD Spadgenske, EW Beaty, TA Melton, RH AF Delaney, David K. Pater, Larry L. Carlile, Lawrence D. Spadgenske, Eric W. Beaty, Timothy A. Melton, Robert H. TI Response of Red-Cockaded Woodpeckers to Military Training Operations SO WILDLIFE MONOGRAPHS LA English DT Article DE behavioral response; flush; Fort Stewart; Georgia; military training; noise disturbance; Picoides borealis; red-cockaded woodpecker; sound recording; video surveillance; woodpecker weighting curve ID BRAIN-STEM-RESPONSES; BUDGERIGARS MELOPSITTACUS-UNDULATUS; SOUTHERN FLYING SQUIRRELS; GENERALIZED LINEAR-MODELS; HUMAN DISTURBANCE; PICOIDES-BOREALIS; SOUND-PROPAGATION; RAT SNAKES; INTERSPECIFIC COMPETITION; BEHAVIORAL-RESPONSES AB Military lands are a valuable resource in recovery of threatened, endangered, and at-risk species worldwide and have the highest density of threatened and endangered species of all major land management agencies in the United States. Many red-cockaded woodpeckers (Picoides borealis) that reside on federal lands occur on 15 military installations in the southeastern United States. This close association has increased concern over potential conflicts between conservation requirements of endangered species and the military's mission of combat readiness. Our objectives were to 1) determine if military training operations affect behavior, reproductive success, and productivity of red-cockaded woodpeckers; 2) develop a frequency-weighting function to assess woodpecker hearing sensitivity; 3) identify factors that affect woodpecker responses to military training operations; 4) develop distance and dose-response thresholds for quantifying woodpecker responses to noise levels and stimulus distances; 5) characterize military training operations through quantification of sound levels, source identification, distance from active woodpecker nests, frequency spectra, duration, and frequency of occurrence; and 6) document baseline woodpecker nesting behavior. We conducted our study on the Fort Stewart Military Installation located in southeast Georgia, USA. Downy woodpeckers, as surrogates for red-cockaded woodpeckers, had their best hearing sensitivity within the peak range of the power spectrum of both downy and red-cockaded woodpecker vocalizations, which is at a higher frequency than that of a typical passerine. Overall, woodpeckers had a reduced auditory sensitivity relative to human hearing sensitivity and other species of small birds, especially in the frequency range >4 kHz. Woodpeckers were most sensitive in the 1.5- to 4.0-kHz range. Sensitivity appeared to drop off quickly at frequencies <1.0 kHz and >4.0 kHz. Overall, we did not find that the woodpecker-frequency-weighting function we developed provided a better predictor of woodpecker flush response compared with A-weighting. More research is needed to better understand the relationship between frequency-weighting functions and woodpecker response behavior. Potential breeding groups of woodpeckers across the population increased from 158 in 1997 to 181 in 2000, wheras nesting groups increased from 141 in 1998 to 170 in 2000, for overall increases of 14.6% and 20.6%, respectively, over the 3 years of this project. Fledging success rates for individual nests within the overall population remained consistent from 1998 to 2000, averaging 84.4%. Mean clutch sizes for woodpecker groups for 1998 to 2000 ranged from 2.75 to 3.01 eggs/nest, brood size ranged from 2.01 to 2.22 nestlings/nest, whereas the average number of young fledged ranged from 1.57 to 1.76 young/occupied nest. We observed no difference in reproductive success or productivity between experimental and control-tested red-cockaded woodpecker groups. Overall, experimental test groups produced an average of 2.98 eggs/nest, 1.89 nestlings/nest, and 1.54 young/occupied nest from 1999 to 2000, compared with 2.73 eggs/nest, 1.91 nestlings/nest, and 1.57 young/occupied nest at control groups. We measured behavioral responses (nest attendance and arrivals and departures from the nest) of red-cockaded woodpeckers to military training events through direct and indirect (i.e., video surveillance) observation of 464. 5 hours of woodpecker nesting behavior before and after controlled experimental events while recording and characterizing militry-generated sound events using sound-recording equipment. We presented woodpeckers with actual 0.50-caliber blank machine gun fire and artillery simulators from controlled distances to develop distance and sound thresholds. We used video surveillance to document potential behavioral responses of woodpeckers primarily during nonexperimental military training operations in areas that could not be safely monitored and to determine baseline woodpecker nesting behaviors. We recorded 2,846 nonexperimental military noise events in 157 data sessions at 50 red-cockaded woodpecker groups from 1998 to 2000. We also recorded 206 experimental tests at 58 woodpecker groups during 1999 and 2000. Life-table analyses of flush response time showed that at short ranges (15-30 m) the flush response was stronger for artillery simulator blasts than for blank fire in both the incubation and the nestling phases. In contrast, at medium distances (45-60 m) blank fire tended to produce more flush responses than artillery fire in both incubation and nestling phases. At longer distances (>60 m), blank fire and artillery produced similar flush responses in the incubation phase, whereas flush response was stronger for blank fire than for artillery in the nestling phase. In general, most animals that responded to military activity flushed within 5 seconds of the stimulus event. Woodpeckers returned to nests within an average of 4.4 minutes after being flushed by artillery simulators and 6.3 minutes after 0.50-caliber blank-fire tests. Woodpecker flush response rates increased as stimulus distance decreased and sound levels increased, regardless of stimulus type or year. Woodpeckers did not flush from nests when 0.50-caliber blank machine gun fire and artillery simulators were >152 m away and sound-exposure levels (decibels [dB]) were <68 dBW (woodpecker-based frequency-weighting curve) and <65 dBW, respectively. We found that blast treatments reduced arrival rates of adults at the nest, with the amount of reduction dependent on the type of blast stimulus and number of helpers at the nest. On the other hand, blast treatments had no detectable effects on nest attendance. The effect of blank fire on incubation-phase arrivals over a 30-minute interval (about 40% reduction) was nearly twice that of artillery simulator fire (about a 20% reduction). There was no evidence supporting any effect of stimulus type on arrivals during the nestling phase. Blast stimuli during incubation reduced arrivals by 40% when no helpers were present, but the strength of this effect decreased to 28% when one helper was present, and was only 6% for nests with >= 2 helpers. Distance of the blast from the nest did not affect the response of arrival rates to blast treatments. Infrequent, short-duration military training exercises, as measured, did not appear to substantially impact red-cockaded woodpecker reproductive success and productivity on the Fort Stewart Military Installation. Our results may be applicable to other military installations where similar training activities and intensity levels occur. Additional research is needed to address possible habituation or sensitization of red-cockaded woodpeckers to human activities in proximity to active nest sites. Although we attempted to monitor woodpecker response to a number of military training activities, other types of military training operations or human-based activities with louder noise, longer duration, incrased human presence, and greater frequency of occurrence could more negatively influence woodpecker nesting behavior and need to be investigated. Our results do not support the hypothesis that military maneuver training operations are limiting factors in the recovery of red-cockaded woodpeckers on military installations, based on our level and type of testing. Natural resource management policies on military installations have had a positive influence on the recovery of red-cockaded woodpeckers and probably outweigh the negative effects of typical military training. (C) 2011 The Wildlife Society. C1 [Delaney, David K.; Pater, Larry L.] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Carlile, Lawrence D.; Spadgenske, Eric W.; Beaty, Timothy A.] Environm Div, Ft Stewart, GA 31314 USA. RP Delaney, DK (reprint author), USA, Engn Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM david.delaney@erdc.usace.army.mil FU Strategic Environmental Research and Development Program [CS-1083]; Construction Engineering Research Laboratory (CERL) of the Engineer Research and Development Center for the United States Army Corps of Engineers; United States Army Forces Command FX Our study was supported by the United States Army Forces Command and the Fort Stewart Army Installation with funding from the Strategic Environmental Research and Development Program, under Conservation Project No. CS-1083, and the Construction Engineering Research Laboratory (CERL), which is part of the Engineer Research and Development Center for the United States Army Corps of Engineers. Publication costs were provided by CERL. We thank T. Brewton, H. Erickson, M. Fay, T. Hasty, M. Huffman, M. Klich, S. Kovac, B. Platt, A. Rinker, and A. Walde for assisting with data collection. A. Cone, B. MacAllister, L. Nguyen, C. Smith, and A. Walde assisted in reviewing videotapes. T. Grubb, A. Walde, and T. Brewton assisted in placing video cameras. We thank W. Wolfe and C. Stewart for translating services. We especially appreciate the skill and cooperation of the 1st Battalion, 64th Armor Regiment; 2nd Battalion, 7th Infantry; 3rd Battalion, 7th Infantry; 3rd Squadron, 7th Cavalry; and the 10th Engineer Battalion and thank them for personnel and supplies. The Directorate of Training Office, particularly H. Bullard, J. Caligiure, T. Tellames, and D. Brown, provided important logistical support. The Environmental Division at Fort Stewart also provided logistical support and conducted most of the red-cockaded woodpecker nest surveys. We thank R. Dooling, B. Lohr, B. Britton-Powell, and their laboratory staff for providing woodpecker hearing sensitivity data. R. Owens created installation maps. B. Bivings, R. Costa, T. Hayden, T. Reid, and W. Woodson provided important suggestions during initiation of the study and supported the work throughout. W. Russell assisted in providing acoustical training to field personnel. We thank A. Anderson, Ann Bowles, H. Balbach, B. Bivings, R. Costa, S. Hodapp, T. Hayden, R. Holst, T. Reid, W. Russell, W. Severinghaus, J. Walters, W. Woodson, and one anonymous person for their reviews of earlier drafts of the manuscript. NR 168 TC 11 Z9 12 U1 9 U2 57 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0084-0173 EI 1938-5455 J9 WILDLIFE MONOGR JI Wildl. Monogr. PD JUL PY 2011 IS 177 BP 1 EP 38 DI 10.1002/wmon.3 PG 38 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 794BM UT WOS:000292869700001 ER PT J AU Akala, HM Eyase, FL Cheruiyot, AC Omondi, AA Ogutu, BR Waters, NC Johnson, JD Polhemus, ME Schnabel, DC Walsh, DS AF Akala, Hoseah M. Eyase, Fredrick L. Cheruiyot, Agnes C. Omondi, Angela A. Ogutu, Bernhards R. Waters, Norman C. Johnson, Jacob D. Polhemus, Mark E. Schnabel, David C. Walsh, Douglas S. TI Antimalarial Drug Sensitivity Profile of Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I in vitro Assay and Molecular Analysis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TIME QUANTITATIVE PCR; PFMDR1 GENE; DIHYDROFOLATE-REDUCTASE; MEFLOQUINE RESISTANCE; MULTIDRUG-RESISTANCE; FLUORESCENCE ASSAY; CANDIDATE GENES; MALARIA; SUSCEPTIBILITY; CHLOROQUINE AB In vitro drug sensitivity and molecular analyses of Plasmodium falciparum track drug resistance. DNA-binding fluorescent dyes like SYBR Green I may allow field laboratories, proximal to P falciparum collection sites, to conduct drug assays. In 2007-2008, we assayed 121 P falciparum field isolates from western Kenya for 50% inhibitory concentrations (IC(50)) against 6 antimalarial drugs using a SYBR Green 1 in vitro assay: 91 immediate ex vivo (IEV) and 30 culture-adapted, along with P falciparum reference clones D6 (chloroquine [CQ] sensitive) and W2 (CO resistant). We also assessed P falciparum mdr1 (Pfmdr1) copy number and single nucleotide polymorphisms (SNPs) at four codons. The IC(50)s for IEV and culture-adapted P. falciparum isolates were similar, and approximated historical IC(50)s. For Pfmdr1, mean copy number was 1, with SNPs common at codons 86 and 184. The SYBR Green I assay adapted well to our field-based laboratory, for both IEV and culture-adapted P falciparum, warranting continued use. C1 Global Emerging Infect Surveillance GEIS Program, USAMRU K, Kenya Med Res Inst KEMRI, Walter Reed Project, Kisumu Nairobi, Kenya. US Mil Acad, West Point, NY 10996 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Walsh, DS (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM douglas.walsh@afrims.org FU U.S. Department of Defense Global Emerging Infections System, Silver Spring, Maryland FX This work was supported by the U.S. Department of Defense Global Emerging Infections System, Silver Spring, Maryland. NR 40 TC 19 Z9 22 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2011 VL 85 IS 1 BP 34 EP 41 DI 10.4269/ajtmh.2011.10-0674 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 788GK UT WOS:000292433200007 PM 21734121 ER PT J AU Curley, JM Mody, RM Gasser, RA AF Curley, Justin M. Mody, Rupal M. Gasser, Robert A., Jr. TI Case Report: Malaria Caused by Plasmodium vivax Complicated by Acalculous Cholecystitis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FALCIPARUM INFECTION; DIAGNOSIS; CHILD; PATIENT AB We report the first adult cases of acute acalculous cholecystitis (AAC) exclusively caused by infections with Plasmodium vivax. We reviewed the previous cases of AAC occurring during malaria, compared and contrasted the variables of previously reported cases with the cases reported here, examined the pathogenic link between malaria and AAC, and considered the diagnostic pitfalls and treatment implications as they applied to clinical outcomes in patients with this serious and potentially underrecognized illness. C1 [Curley, Justin M.] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. RP Curley, JM (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM justin.m.curley@us.army.mil NR 35 TC 4 Z9 5 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2011 VL 85 IS 1 BP 42 EP 49 DI 10.4269/ajtmh.2011.10-0724 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 788GK UT WOS:000292433200008 PM 21734122 ER PT J AU Dower, K Rubins, KH Hensley, LE Connor, JH AF Dower, Ken Rubins, Kathleen H. Hensley, Lisa E. Connor, John H. TI Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression SO ANTIVIRAL RESEARCH LA English DT Article DE Orthopoxvirus; Antiviral; Gene expression; High-throughput; Drug discovery ID GREEN FLUORESCENT PROTEIN; TRANSCRIPTION ELONGATION-FACTOR; DNA-REPLICATION; MESSENGER-RNAS; MONKEYPOX; SMALLPOX; INTERMEDIATE; CELLS; GENERATION; SELECTION AB Vaccinia virus is the prototypical orthopoxvirus of Poxviridae, a family of viruses that includes the human pathogens Variola (smallpox) and Monkeypox. Core viral functions are conserved among orthopoxviruses, and consequently Vaccinia is routinely used to study poxvirus biology and screen for novel antiviral compounds. Here we describe the development of a series of fluorescent protein-based reporter Vaccinia viruses that provide unprecedented resolution for tracking viral function. The reporter viruses are divided into two sets: (1) single reporter viruses that utilize temporally regulated early, intermediate, or late viral promoters; and (2) multi-reporter viruses that utilize multiple temporally regulated promoters. Promoter and reporter combinations were chosen that yielded high signal-to-background for stage-specific viral outputs. We provide examples for how these viruses can be used in the rapid and accurate monitoring of Vaccinia function and drug action. (C) 2011 Elsevier B.V. All rights reserved. C1 [Dower, Ken; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Dower, Ken; Rubins, Kathleen H.] Nine Cambridge Ctr, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, 72 E Concord St, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Connor, John/0000-0002-8867-7256 FU NIMH NIH HHS [R03 MH094169, R03 MH094169-01] NR 32 TC 11 Z9 11 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JUL PY 2011 VL 91 IS 1 BP 72 EP 80 DI 10.1016/j.antiviral.2011.04.014 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 791MS UT WOS:000292669900011 PM 21569797 ER PT J AU Busby, RR Gebhart, DL Stromberger, ME Meiman, PJ Paschke, MW AF Busby, Ryan R. Gebhart, Dick L. Stromberger, Mary E. Meiman, Paul J. Paschke, Mark W. TI Early seral plant species' interactions with an arbuscular mycorrhizal fungi community are highly variable SO APPLIED SOIL ECOLOGY LA English DT Article DE Arbuscular mycorrhizal fungi; Soil restoration; Invasive species; Plant colonizers; Mycorrhizal interaction strength; Plant community assembly ID SEMI-ARID WEST; TALLGRASS PRAIRIE; REVEGETATION PRACTICES; DIVERSITY; GRASSLAND; COLONIZATION; FEEDBACK; ROOTS; ENDOMYCORRHIZAE; PRODUCTIVITY AB Arbuscular mycorrhizal fungi (AMF) are an important driver of plant community assembly, and as such may be critical for restoring plant communities. Previous work has shown that as plant communities develop, AMF density is a good predictor of what type of plant community is supported. However, interactions between plants, particularly facultative hosts, and AMF are often assumed from plant growth responses and lack concomitant AMF growth response data. We examined both plant and AMF responses in association using early- and mid-seral plant hosts and a homogenous AMF community. The goal was to determine how variable interactions are between facultative plant hosts and an AMF community. Plant responsiveness was measured using field soil with and without AMF. AMF density was measured by observing root colonization by AMF in a bioassay host plant grown in soils trained by the individual host plant species used in the plant responsiveness study. Plant species studied were highly variable in their interactions with AMF, and mutualisms, parasitisms, amensalisms and commensalisms were all prevalent. The presence of certain AMF facilitators may have a strong founder effect on plant communities and, where such feedbacks exist, identifying and utilizing these key interactions might facilitate the restoration of degraded ecosystems. (C) 2011 Elsevier B.V. All rights reserved. C1 [Meiman, Paul J.; Paschke, Mark W.] Colorado State Univ, Dept Forest Rangeland & Watershed Stewardship, Ft Collins, CO 80523 USA. [Busby, Ryan R.; Stromberger, Mary E.; Meiman, Paul J.; Paschke, Mark W.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80523 USA. [Busby, Ryan R.; Gebhart, Dick L.] USA, Engn Res & Dev Center, Construct Engn Lab, Champaign, IL 61822 USA. [Stromberger, Mary E.] Colorado State Univ, Dept Soil & Crop Sci, Ft Collins, CO 80523 USA. RP Paschke, MW (reprint author), Colorado State Univ, Dept Forest Rangeland & Watershed Stewardship, 1472 Campus Delivery, Ft Collins, CO 80523 USA. EM ryan.r.busby@usace.army.mil; dick.l.gebhart@usace.army.mil; mary.stromberger@colostate.edu; paul.meiman@colostate.edu; Mark.Paschke@colostate.edu RI Stromberger, Mary/C-3070-2013; Paschke, Mark/E-3799-2013 OI Stromberger, Mary/0000-0002-5862-2932; Paschke, Mark/0000-0002-6345-5905 FU United States Army [A896] FX We thank M. Rout for reviewing the manuscript, J. Rieder, and L Perry for comments on the study design, and Brett Wolk and the Colorado State University Restoration Ecology Lab for assistance with field experiments. This research was funded by the United States Army A896 Direct Funded Research Program. NR 41 TC 7 Z9 7 U1 0 U2 56 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0929-1393 J9 APPL SOIL ECOL JI Appl. Soil Ecol. PD JUL PY 2011 VL 48 IS 3 BP 257 EP 262 DI 10.1016/j.apsoil.2011.04.014 PG 6 WC Soil Science SC Agriculture GA 791ZZ UT WOS:000292711600001 ER PT J AU Brietzke, SE AF Brietzke, Scott E. TI Endoscopic Sinus Surgery in Children: Con SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID CHRONIC RHINOSINUSITIS; FACIAL GROWTH; PEDIATRIC RHINOSINUSITIS; ADENOIDECTOMY; MANAGEMENT C1 Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM SEBrietzke@msn.com OI Brietzke, Scott/0000-0002-2844-6026 NR 21 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD JUL PY 2011 VL 137 IS 7 BP 699 EP 701 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 793GL UT WOS:000292808300009 PM 21768416 ER PT J AU O'Leary, VB Ovsepian, SV Raghunath, A Huo, Q Lawrence, GW Smith, L Dolly, JO AF O'Leary, V. B. Ovsepian, S. V. Raghunath, A. Huo, Q. Lawrence, G. W. Smith, L. Dolly, J. O. TI Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons SO GENE THERAPY LA English DT Article DE lentivirus; SNAREs; synaptic transmission; ganglionopathies ID CENTRAL-NERVOUS-SYSTEM; CLOSTRIDIAL NEUROTOXINS; GENE DELIVERY; TETANUS TOXIN; CHROMAFFIN CELLS; IN-VIVO; CORE STREPTAVIDIN; MOTOR-NEURONS; SPINAL-CORD; SNAP-25 AB Fragments of botulinum neurotoxin (BoNT) have been explored as potential targeting moieties and carriers of biomolecules into neurons, although with lower binding and translocation efficiency compared with intact proteins. This study exploits a detoxified recombinant form of full-length BoNT/B (BoTIM/B) fused with core streptavidin (CS-BoTIM/B) for lentiviral targeting to central and autonomic neurons. CS-BoTIM/B underwent an activity-dependent entry into cultured spinal cord neurons. Coupling CS-BoTIM/B to biotinylated lentivirus-encoding green fluorescent protein (GFP) endowed considerable neuron selectivity to the vector as evident from the preferential expression of the reporter in neurons co-cultured with skeletal muscle cells. CS-BoTIM/ B-guided lentiviral transduction with the expression of a SNARE protein, SNAP-25 (S25), rendered non-susceptible to proteolysis by three BoNT serotypes, yielded a sizable decrease in cleaved S25 upon exposure of spinal cord neurons to these toxins. This was accompanied by synaptic transmission being spared from blockade by BoNT/A or BoNT/E, reflecting adequate translation and functional competence of recombinant multi-toxin-resistant S25. The augmented neurotropism conveyed on the lentivirus by CS-BoTIM/B was also demonstrated in vivo through enhanced expression of a reporter in intramural ganglionic neurons in the rat trachea, after injection of the targeted GFP-encoding lentivirus. Thus, a novel and realistic prospect for gene therapy of peripheral neuropathies is offered in this study through lentiviral targeting to neurons by CS-BoTIM/ B. Gene Therapy (2011) 18, 656-665; doi:10.1038/gt.2011.8; published online 3 March 2011 C1 [O'Leary, V. B.; Ovsepian, S. V.; Raghunath, A.; Huo, Q.; Lawrence, G. W.; Dolly, J. O.] Dublin City Univ, Int Ctr Neurotherapeut, Dublin 9, Ireland. [Smith, L.] USA, Off Chief Sci, Med Res Inst Infect Dis, Frederick, MD USA. RP Dolly, JO (reprint author), Dublin City Univ, Int Ctr Neurotherapeut, Collins Ave, Dublin 9, Ireland. EM oliver.dolly@dcu.ie RI Lawrence, Gary/F-3949-2012; Dolly, Oliver/G-1532-2012; OI Dolly, Oliver/0000-0002-0861-5320; O'Leary, Valerie/0000-0003-1171-9830 FU USAMRIID [HDTRA1-07-C-0034]; Science Foundation Ireland FX This study is supported by USAMRIID (grant number HDTRA1-07-C-0034) and a Research Professorship plus Principal Investigator award (to JOD) from the Science Foundation Ireland. We are grateful to Dr Jiafu Wang for providing the pET-29a clone of BoNT/B and Liam Ryan for technical assistance. NR 61 TC 14 Z9 15 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0969-7128 J9 GENE THER JI Gene Ther. PD JUL PY 2011 VL 18 IS 7 BP 656 EP 665 DI 10.1038/gt.2011.8 PG 10 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 789IU UT WOS:000292509900003 PM 21368902 ER PT J AU Xu, XJ Santee, WR AF Xu, Xiaojiang Santee, William R. TI Sweat loss prediction using a multi-model approach SO INTERNATIONAL JOURNAL OF BIOMETEOROLOGY LA English DT Article DE Sweat; Prediction; Model; Thermal strain; Fluid intake ID PHYSIOLOGICAL-RESPONSES; HUMAN THERMOREGULATION; TEMPERATURE RESPONSE; CORE TEMPERATURE; WIDE-RANGE; HEAT; MODEL; SIMULATION; WORK AB A new multi-model approach (MMA) for sweat loss prediction is proposed to improve prediction accuracy. MMA was computed as the average of sweat loss predicted by two existing thermoregulation models: i.e., the rational model SCENARIO and the empirical model Heat Strain Decision Aid (HSDA). Three independent physiological datasets, a total of 44 trials, were used to compare predictions by MMA, SCENARIO, and HSDA. The observed sweat losses were collected under different combinations of uniform ensembles, environmental conditions (15-40A degrees C, RH 25-75%), and exercise intensities (250-600 W). Root mean square deviation (RMSD), residual plots, and paired t tests were used to compare predictions with observations. Overall, MMA reduced RMSD by 30-39% in comparison with either SCENARIO or HSDA, and increased the prediction accuracy to 66% from 34% or 55%. Of the MMA predictions, 70% fell within the range of mean observed value +/- SD, while only 43% of SCENARIO and 50% of HSDA predictions fell within the same range. Paired t tests showed that differences between observations and MMA predictions were not significant, but differences between observations and SCENARIO or HSDA predictions were significantly different for two datasets. Thus, MMA predicted sweat loss more accurately than either of the two single models for the three datasets used. Future work will be to evaluate MMA using additional physiological data to expand the scope of populations and conditions. C1 [Xu, Xiaojiang; Santee, William R.] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Xu, XJ (reprint author), USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM xiaojiang.xu@us.army.mil NR 25 TC 3 Z9 3 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0020-7128 J9 INT J BIOMETEOROL JI Int. J. Biometeorol. PD JUL PY 2011 VL 55 IS 4 BP 501 EP 508 DI 10.1007/s00484-010-0371-8 PG 8 WC Biophysics; Environmental Sciences; Meteorology & Atmospheric Sciences; Physiology SC Biophysics; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Physiology GA 789YR UT WOS:000292556100005 PM 20890784 ER PT J AU Lundy, JB Lairet, K Chung, KK Renz, EM AF Lundy, Jonathan B. Lairet, Kimberly Chung, Kevin K. Renz, Evan M. TI Routine Laboratory Monitoring for Low-Molecular-Weight Heparin Prophylaxis in Burns? Not So Fast! SO JOURNAL OF BURN CARE & RESEARCH LA English DT Letter ID XA LEVELS; ENOXAPARIN C1 [Lundy, Jonathan B.; Lairet, Kimberly; Chung, Kevin K.; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Lundy, JB (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2011 VL 32 IS 4 BP E155 EP E155 DI 10.1097/BCR.0b013e3182223f52 PG 1 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 789TA UT WOS:000292538000009 PM 21577136 ER PT J AU Bejon, P Cook, J Bergmann-Leitner, E Olotu, A Lusingu, J Mwacharo, J Vekemans, J Njuguna, P Leach, A Lievens, M Dutta, S von Seidlein, L Savarese, B Villafana, T Lemnge, MM Cohen, J Marsh, K Corran, PH Angov, E Riley, EM Drakeley, CJ AF Bejon, Philip Cook, Jackie Bergmann-Leitner, Elke Olotu, Ally Lusingu, John Mwacharo, Jedidah Vekemans, Johan Njuguna, Patricia Leach, Amanda Lievens, Marc Dutta, Sheetij von Seidlein, Lorenz Savarese, Barbara Villafana, Tonya Lemnge, Martha M. Cohen, Joe Marsh, Kevin Corran, Patrick H. Angov, Evelina Riley, Eleanor M. Drakeley, Chris J. TI Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01(E) on Blood Stage Immunity in Young Children SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM TRANSMISSION; MOZAMBICAN CHILDREN; ANTIBODY-RESPONSES; GROWTH-INHIBITION; CLINICAL MALARIA; FEBRILE MALARIA; PARASITE GROWTH; PROTECTION; INFECTION; EFFICACY AB Background. RTS,S/AS01(E) is the lead candidate malaria vaccine and confers pre-erythrocytic immunity. Vaccination may therefore impact acquired immunity to blood-stage malaria parasites after natural infection. Methods. We measured, by enzyme-linked immunosorbent assay, antibodies to 4 Plasmodium falciparum merozoite antigens (AMA-1, MSP-1(42), EBA-175, and MSP-3) and by growth inhibitory activity (GIA) using 2 parasite clones (FV0 and 3D7) at 4 times on 860 children who were randomized to receive with RTS,S/AS01(E) or a control vaccine. Results. Antibody concentrations to AMA-1, EBA-175, and MSP-1(42) decreased with age during the first year of life, then increased to 32 months of age. Anti-MSP-3 antibody concentrations gradually increased, and GIA gradually decreased up to 32 months. Vaccination with RTS,S/AS01(E) resulted in modest reductions in AMA-1, EBA-175, MSP-1(42), and MSP-3 antibody concentrations and no significant change in GIA. Increasing anti-merozoite antibody concentrations and GIA were prospectively associated with increased risk of clinical malaria. Conclusions. Vaccination with RTS,S/AS01(E) reduces exposure to blood-stage parasites and, thus, reduces anti-merozoite antigen antibody concentrations. However, in this study, these antibodies were not correlates of clinical immunity to malaria. Instead, heterogeneous exposure led to confounded, positive associations between increasing antibody concentration and increasing risk of clinical malaria. C1 [Bejon, Philip; Marsh, Kevin] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Nuffield Dept Med, Oxford OX3 7LJ, England. [Bejon, Philip; Olotu, Ally; Mwacharo, Jedidah; Njuguna, Patricia; Marsh, Kevin] Kenya Govt Med Res Ctr, Wellcome Trust Programme, Ctr Geog Med Res, Kilifi, Kenya. [Cook, Jackie; von Seidlein, Lorenz; Corran, Patrick H.; Riley, Eleanor M.; Drakeley, Chris J.] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immun & Infect, London, England. [Corran, Patrick H.] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England. [Bergmann-Leitner, Elke; Dutta, Sheetij; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Savarese, Barbara; Villafana, Tonya] PATH Malaria Vaccine Initiat, Bethesda, MD USA. [Villafana, Tonya] MedImmune LLC, Gaithersburg, MD USA. [Vekemans, Johan; Leach, Amanda; Lievens, Marc; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [von Seidlein, Lorenz] Menzies Sch Hlth Res, Casuarina, Australia. [Lusingu, John] Univ Copenhagen, Ctr Med Parasitol, DK-1168 Copenhagen, Denmark. RP Bejon, P (reprint author), Univ Oxford, Ctr Clin Vaccinol & Trop Med, Nuffield Dept Med, S Parks Rd, Oxford OX3 7LJ, England. EM pbejon@kilifi.kemri-wellcome.org RI Riley, Eleanor/C-8960-2013 OI Riley, Eleanor/0000-0003-3447-3570 FU PATH Malaria Vaccine Initiative, GlaxoSmithKline Biologicals; Wellcome Trust; NIHR Biomedical Research Centre in Oxford FX This work was supported by PATH Malaria Vaccine Initiative, GlaxoSmithKline Biologicals, the Wellcome Trust (to C. D., J. C., and K. M.), and the NIHR Biomedical Research Centre in Oxford (to P. B.). NR 50 TC 28 Z9 28 U1 2 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 1 PY 2011 VL 204 IS 1 BP 9 EP 18 DI 10.1093/infdis/jir222 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 790AV UT WOS:000292561800004 PM 21628653 ER PT J AU Greenhouse, B Ho, B Hubbard, A Njama-Meya, D Narum, DL Lanar, DE Dutta, S Rosenthal, PJ Dorsey, G John, CC AF Greenhouse, Bryan Ho, Benjamin Hubbard, Alan Njama-Meya, Denise Narum, David L. Lanar, David E. Dutta, Sheetij Rosenthal, Philip J. Dorsey, Grant John, Chandy C. TI Antibodies to Plasmodium falciparum Antigens Predict a Higher Risk of Malaria But Protection From Symptoms Once Parasitemic SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LIVER-STAGE ANTIGEN-1; MEROZOITE SURFACE PROTEIN-1; CLINICAL MALARIA; HIGHLAND AREA; CIRCUMSPOROZOITE PROTEIN; VACCINE CANDIDATES; ESCHERICHIA-COLI; UGANDAN CHILDREN; WESTERN KENYA; TRANSMISSION AB Background. Associations between antibody responses to Plasmodium falciparum antigens and protection against symptomatic malaria have been difficult to ascertain, in part because antibodies are potential markers of both exposure to P. falciparum and protection against disease. Methods. We measured IgG responses to P. falciparum circumsporozoite protein, liver-stage antigen 1, apical-membrane antigen 1 (AMA-1), and merozoite surface proteins (MSP) 1 and 3, in children in Kampala, Uganda, and measured incidence of malaria before and after antibody measurement. Results. Stronger responses to all 5 antigens were associated with an increased risk of clinical malaria (P < .01) because of confounding with prior exposure to P. falciparum. However, with use of another assessment, risk of clinical malaria once parasitemic, stronger responses to AMA-1, MSP-1, and MSP-3 were associated with protection (odds ratios, 0.34, 0.36, and 0.31, respectively, per 10-fold increase; P < .01). Analyses assessing antibodies in combination suggested that any protective effect of antibodies was overestimated by associations between individual responses and protection. Conclusions. Using the risk of symptomatic malaria once parasitemic as an outcome may improve detection of associations between immune responses and protection from disease. Immunoepidemiology studies designed to detect mechanisms of immune protection should integrate prior exposure into the analysis and evaluate multiple immune responses. C1 [Greenhouse, Bryan; Rosenthal, Philip J.; Dorsey, Grant] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Hubbard, Alan] Univ Calif Berkeley, Div Biostat, Berkeley, CA 94720 USA. [Ho, Benjamin; John, Chandy C.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA. [Njama-Meya, Denise] Makerere Univ, Kampala, Uganda. [Narum, David L.] NIAID, Malaria Vaccine Dev Branch, Rockville, MD USA. [Lanar, David E.; Dutta, Sheetij] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Greenhouse, B (reprint author), Univ Calif San Francisco, Dept Med, Box 0811, San Francisco, CA 94143 USA. EM bgreenhouse@medsfgh.ucsf.edu OI Greenhouse, Bryan/0000-0003-0287-9111 FU National Institute of Allergy and Infectious Disease (NIAID) [AI052142, AI056270]; Doris Duke Charitable Foundation [2004047]; National Institutes of Health, NIAID, Laboratory of Malaria Immunology and Vaccinology FX This work was supported by the National Institute of Allergy and Infectious Disease (NIAID) (AI052142, AI056270) and the Doris Duke Charitable Foundation (2004047). This work was funded in part by the Intramural Research Program of the National Institutes of Health, NIAID, Laboratory of Malaria Immunology and Vaccinology. NR 50 TC 37 Z9 37 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 1 PY 2011 VL 204 IS 1 BP 19 EP 26 DI 10.1093/infdis/jir223 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 790AV UT WOS:000292561800005 PM 21628654 ER PT J AU Ressler, SJ AF Ressler, Stephen J. TI Sociology of Professions: Application to the Civil Engineering "Raise the Bar" Initiative SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article DE Professions; Professional role; Professional societies; Professional personnel; Engineering education; Professional practice; Licensure AB This paper applies the sociological theory of professions, as espoused by Abbott and Freidson, as a conceptual framework to assess the critical issues associated with the ongoing implementation of ASCE Policy Statement 465-also called the "Raise the Bar" initiative. The sociology of professions provides an objective basis for evaluating key aspects of the initiative, including publication of the civil engineering body of knowledge, raising educational standards for licensure, collaboration with other engineering disciplines, and defining the role of paraprofessionals. The analysis demonstrates the following: (1) the models of professionalism by Abbott and Freidson are highly applicable to civil engineering; (2) most aspects of Policy Statement 465 implementation are consistent with these models; (3) the initiative is contributing to the strength of the profession as intended; and (4) some future additions and adjustments appear to be warranted. From this analysis, the author derives recommendations for the future direction of the Raise the Bar initiative. DOI: 10.1061/(ASCE)EI.1943-5541.0000043. (C) 2011 American Society of Civil Engineers. C1 US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Ressler, SJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM stephen.ressler@usma.edu NR 37 TC 5 Z9 5 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD JUL PY 2011 VL 137 IS 3 BP 151 EP 161 DI 10.1061/(ASCE)EI.1943-5541.0000043 PG 11 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 789MH UT WOS:000292519100005 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI Electromagnetic wave scattering from particles of arbitrary shapes SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 12th International Conference on Electromagnetic and Light Scattering by Nonspherical Particles - Theory, Measurements, and Applications CY JUN 28-JUL 02, 2010 CL Helsinki, FINLAND DE Light scattering; Arbitrary particles; T-matrix; Sh-matrix ID GAUSSIAN RANDOM PARTICLES; LIGHT-SCATTERING; SH-MATRICES; FINITE-CYLINDER; CAPSULE AB We consider a general solution of the electromagnetic wave scattering problem for arbitrarily shaped homogeneous particles, whose surface can be expressed by a function of angular coordinates, using a Laplace series expansion. This can include regularly shaped particles (e.g., ellipsoids and cubes) as well as irregularly shaped particles like Gaussian spheres. For calculations of scattering properties of the particles, we use the approach based on the Sh-matrix. The Sh-matrix elements deduced from the T-matrix technique allow one to separate the shape effects from size- and refractive-index-dependent parameters. The separation also allows the corresponding surface integrals to be solved analytically for different particle shapes. In this manuscript, we give analytical expressions for the Sh-matrix elements for arbitrary shaped particles that can be presented with Laplace series. We find good agreement between results obtained comparing our and DDA calculations. Published by Elsevier Ltd. C1 [Videen, Gorden] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, RDRL CIE S, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gorden.videen@gmail.com NR 17 TC 11 Z9 11 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2011 VL 112 IS 11 SI SI BP 1636 EP 1645 DI 10.1016/j.jqsrt.2011.01.036 PG 10 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 789RL UT WOS:000292533900002 ER PT J AU Berg, MJ Videen, G AF Berg, Matthew J. Videen, Gorden TI Digital holographic imaging of aerosol particles in flight SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 12th International Conference on Electromagnetic and Light Scattering by Nonspherical Particles - Theory, Measurements, and Applications CY JUN 28-JUL 02, 2010 CL Helsinki, FINLAND DE Holography; Light scattering; Aerosol; Imaging ID LINE HOLOGRAPHY; NUMERICAL RECONSTRUCTION; LASER; SOOT AB This work describes the design and application of an apparatus to image aerosol particles using digital holography in a flow-through, contact-free manner. Particles in an aerosol stream are illuminated by a triggered, pulsed laser and the pattern produced by the interference of this light with that scattered by the particles is recorded by a digital camera. The recorded pattern constitutes a digital hologram from which an image of the particles is computationally reconstructed using a fast Fourier transform. This imaging is validated using a cluster of ragweed pollen particles. Examples involving mineral-dust aerosols demonstrate the technique's in situ imaging capability for complex-shaped particles over a size range of roughly 15-500 mu m micrometers. The focusing-like character of the reconstruction process is demonstrated using a NaCl aerosol particle and is compared to a similar particle imaged with a conventional microscope. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Berg, Matthew J.; Videen, Gorden] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Berg, Matthew J.; Videen, Gorden] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. RP Berg, MJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. EM matt.berg@msstate.edu NR 24 TC 19 Z9 21 U1 4 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2011 VL 112 IS 11 SI SI BP 1776 EP 1783 DI 10.1016/j.jqsrt.2011.01.013 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 789RL UT WOS:000292533900018 ER PT J AU Burns, JW Baer, LA Hagerman, EJ Jordan, BS Nelson, JJ Batchinsky, AI Cancio, LC Jones, JA Dubick, MA Wade, CE AF Burns, John W. Baer, Lisa A. Hagerman, Erica J. Jordan, Bryan S. Nelson, Johnny J., Jr. Batchinsky, Andriy I. Cancio, Leopoldo C. Jones, John A. Dubick, Michael A. Wade, Charles E. TI Development and Resuscitation of a Sedated, Mature Male Miniature Swine Severe Hemorrhage Model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE 60% Hemorrhage; Unanesthetized; Hextend; 6% Hydroxyethyl starch; Colloid; 17 beta-estradiol ID BOVINE POLYMERIZED HEMOGLOBIN; ESTROGEN-RECEPTOR-ALPHA; TRAUMA-HEMORRHAGE; CYTOKINE PRODUCTION; CORONARY-ARTERIES; 17-BETA-ESTRADIOL; PIGS; SHOCK; RESPONSES; HORMONES AB Background: A sedated, mature male miniature swine hemorrhage model has been specifically developed to evaluate resuscitation products for the Defense Advanced Research Projects Agency Surviving Blood Loss program. Methods: Animals were placed in a sling, sedated with midazolam, and hemorrhaged 60% of estimated blood volume (similar to 39 mL/kg) exponentially for 1 hour with no resuscitation (control; n = 16). An additional 26 swine were treated similarly, then resuscitated with 1 mL/kg/min of Hextend to a systolic blood pressure of either 65 mm Hg +/- 2 mm Hg (n = 7) or 80 mm Hg +/- 5 mm Hg (n = 7) and with 17 beta-estradiol (E2) at 1 mg/kg (n = 6) or 10 mg/kg (n = 6). Animals were observed for 3 hours with periodic blood sampling. Survival times for the two E2 groups were not significantly different (p = 0.59); therefore, the groups were combined for comparison with control. Results: Hemorrhage resulted in a characteristic hypotension and metabolic acidosis. Survival time for the control swine was 64 minutes +/- 11.5 minutes with a 6% survival at 180 minutes. The 180 minutes Hextend survival was 86% for 65 mm Hg and 100% for 80 mm Hg. E2 survival was 125 minutes +/- 15.3 minutes, significantly different from control (p = 0.01), but E2 survival of 25% at 180 minutes was not different from control. Conclusion: A sedated, sexually mature male miniature swine severe hemorrhage model has been successfully developed, resuscitated with Hextend and used to evaluate E2 as a small volume resuscitation product. C1 [Burns, John W.; Baer, Lisa A.; Hagerman, Erica J.; Jordan, Bryan S.; Nelson, Johnny J., Jr.; Batchinsky, Andriy I.; Cancio, Leopoldo C.; Jones, John A.; Dubick, Michael A.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Dubick, MA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM michael.dubick@amedd.army.mil FU Defense Advanced Research Projects Agency (DARPA) FX Supported by the Defense Advanced Research Projects Agency (DARPA) Surviving Blood Loss (SBL) Program. NR 26 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 IS 1 BP 148 EP 156 DI 10.1097/TA.0b013e3181eaaf6b PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RR UT WOS:000292607400035 PM 21057337 ER PT J AU Belmont, PJ Thomas, D Goodman, GP Schoenfeld, AJ Zacchilli, M Burks, R Owens, BD AF Belmont, Philip J., Jr. Thomas, Dimitri Goodman, Gens P. Schoenfeld, Andrew J. Zacchilli, Michael Burks, Rob Owens, Brett D. TI Combat Musculoskeletal Wounds in a US Army Brigade Combat Team During Operation Iraqi Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Military; Combat; Casualty; Wound; Musculoskeletal; Injury ID IMPROVISED EXPLOSIVE DEVICES; ENDURING FREEDOM; UNITED-STATES; ORTHOPEDIC INJURIES; SURGICAL-TEAM; CASUALTY CARE; EXPERIENCE; TRAUMA; AMPUTATIONS; AFGHANISTAN AB Background: A prospective, longitudinal analysis of musculoskeletal combat injuries sustained by a large combat-deployed maneuver unit has not previously been performed. Methods: A detailed description of the musculoskeletal combat casualty care statistics, distribution of wounds, and mechanisms of injury incurred by a US Army Brigade Combat Team during "The Surge" phase of Operation Iraqi Freedom was performed using a centralized casualty database and an electronic medical record system. Results: Among the 4,122 soldiers deployed, there were 242 musculoskeletal combat wounds in 176 combat casualties. The musculoskeletal combat casualty rate for the Brigade Combat Team was 34.2 per 1,000 soldier combat-years. Spine, pelvis, and long bone fractures comprised 55.9% (33 of 59) of the total fractures sustained in combat. Explosions accounted for 80.7% (142 of 176) of all musculoskeletal combat casualties. Musculoskeletal combat casualty wound incidence rates per 1,000 combat-years were as follows: major amputation, 2.1; minor amputation, 0.6; open fracture, 5.0; closed fracture, 6.4; and soft-tissue/neurovascular injury, 32.8. Among musculoskeletal combat casualties, the likelihood of a gunshot wound causing an open fracture was significantly greater (45.8% [11 of 24]) when compared with explosions (10.6% [15 of 142]) (p = 0.0006). Long bone amputations were more often caused by explosive mechanisms than gunshot wounds. Conclusions: A large burden of complex orthopedic injuries has resulted from the combat experience in Operation Iraqi Freedom. This is because of increased enemy reliance on explosive devices, the use of individual and vehicular body armor, and improved survivability of combat-injured soldiers. C1 [Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Orthopaed Surg Serv, Dept Orthopaed Surg, El Paso, TX 79920 USA. [Burks, Rob] USN, Postgrad Sch, Grad Sch Operat & Informat Sci, Monterey, CA USA. [Owens, Brett D.] US Mil Acad, Keller Army Community Hosp, Dept Orthopaed Surg, West Point, NY 10996 USA. RP Belmont, PJ (reprint author), William Beaumont Army Med Ctr, Orthopaed Surg Serv, Dept Orthopaed Surg, 5005 N Piedras, El Paso, TX 79920 USA. EM philip.belmont@us.army.mil RI Burks, Robert/J-2481-2015; OI Burks, Robert/0000-0001-6443-6653; Belmont, Philip/0000-0003-2618-199X; Schoenfeld, Andrew/0000-0002-3691-1215 NR 38 TC 21 Z9 21 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 IS 1 BP E1 EP E7 DI 10.1097/TA.0b013e3181edebed PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RR UT WOS:000292607400001 PM 21045748 ER PT J AU Bailey, JR Stinner, DJ Blackbourne, LH Hsu, JR Mazurek, MT AF Bailey, James R. Stinner, Daniel J. Blackbourne, Lorne H. Hsu, Joseph R. Mazurek, Michael T. TI Combat-Related Pelvis Fractures in Nonsurvivors SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 6th Research Symposium on Extremity War Injuries (EWI) CY 2011 CL Washington, DC DE Pelvis; Fractures; Combat; Wartime; Associated injuries; Mortality ID MORTALITY; TRAUMA; INJURIES; CLASSIFICATION; MANAGEMENT; OUTCOMES AB Background: The purpose of this study was to describe pelvic fractures and their associated injuries in service members who either died of wounds or were killed in action during Operation Iraqi Freedom and Operation Enduring Freedom and define any differences in associated injuries between penetrating versus blunt injury to the pelvis. Methods: A review of all service members who sustained a pelvis fracture during Operation Iraqi Freedom and Operation Enduring Freedom in the year 2008 was performed. Data were recorded for analysis. Results: One hundred four nonsurvivors were identified with pelvic fractures. Appropriate records, photos, and radiographs were available for 91, 70 were classified as "Not Survivable" (77%) and 21 "Potentially Survivable" (23%). Mechanisms of injury included 69 blast (76%), 14 gunshot wounds (15%), 4 motor vehicle accidents (4.5%), and 4 "other" (4.5%). Direct injury to the pelvis was penetrating in 60 (66%) and blunt in 31 (34%). Large pelvic vessel injury was observed more frequently in penetrating pelvic injuries (27%) than blunt injuries (3%). Hollow viscus abdominal injuries were more common in those with penetrating (57%) than blunt injuries (10%). There was an inverse relationship with intra-abdominal, solid organ injuries (blunt, 81%; penetrating, 55%). Head injuries were also more common in blunt pelvic injuries (blunt, 68%; penetrating, 45%), as were cardiopulmonary injuries (blunt, 84%, penetrating injuries, 57%). Conclusions: Large pelvic vessel and hollow viscus injuries occur more frequently in penetrating combat-related pelvic fractures, whereas intra-abdominal solid organ, head, and cardiopulmonary injuries are more common in blunt pelvic injuries. C1 [Bailey, James R.; Mazurek, Michael T.] USN, Dept Orthopaed Surg, San Diego Med Ctr, San Diego, CA 92134 USA. [Stinner, Daniel J.; Blackbourne, Lorne H.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Bailey, JR (reprint author), USN, Dept Orthopaed Surg, San Diego Med Ctr, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. EM James.Bailey@med.navy.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 25 TC 8 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S58 EP S61 DI 10.1097/TA.0b013e31822154d8 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900010 PM 21795891 ER PT J AU Blackbourne, LH Baer, DG Cestero, RF Inaba, K Rasmussen, TE AF Blackbourne, Lorne H. Baer, David G. Cestero, Ramon F. Inaba, Kenji Rasmussen, Todd E. TI Exsanguination Shock: The Next Frontier in Prevention of Battlefield Mortality SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID COMBAT CASUALTY CARE; IRREVERSIBLE HEMORRHAGIC-SHOCK; OPERATION-ENDURING-FREEDOM; IMPROVES SURVIVAL; DEATH; INJURY; SYSTEM; DAMAGE; DOGS; WAR C1 [Blackbourne, Lorne H.; Baer, David G.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cestero, Ramon F.] USN, Med Res Unit San Antonio, Ft Sam Houston, TX USA. [Inaba, Kenji] Univ So Calif, Div Trauma & Crit Care, Los Angeles, CA USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3698 Chambers Pass,BLDG 3611, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil NR 26 TC 10 Z9 10 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S1 EP S3 DI 10.1097/TA.0b013e3182211286 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900001 PM 21795887 ER PT J AU Cap, AP Baer, DG Orman, JA Aden, J Ryan, K Blackbourne, LH AF Cap, Andrew P. Baer, David G. Orman, Jean A. Aden, James Ryan, Kathy Blackbourne, Lorne H. TI Tranexamic Acid for Trauma Patients: A Critical Review of the Literature SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Tranexamic acid; Antifibrinolytic agents; Hemorrhage/drug therapy; Wounds and injuries/complications ID PARTIAL THROMBOPLASTIN TIME; RECOMBINANT FACTOR VIIA; HYPERCOAGULABLE STATE; ACUTE COAGULOPATHY; PROTHROMBIN TIME; HEMORRHAGE; INJURY; THROMBOELASTOGRAPHY; HYPERFIBRINOLYSIS; TRANSFUSION AB Background: Tranexamic acid (TXA) is an antifibrinolytic that inhibits both plasminogen activation and plasmin activity, thus preventing clot breakdown rather than promoting new clot formation. TXA has been used around the world to safely control bleeding since the 1960s. A large randomized trial recently conducted in >20,000 trauma patients adds to the large body of data documenting the usefulness of TXA in promoting hemostasis. Methods: We reviewed the literature describing use of TXA in a variety of settings including trauma. Results: TXA has been safely used across a wide range of clinical settings to control hemorrhage. The results of a large, randomized, placebo-controlled trial support the use of TXA to treat bleeding trauma patients. Conclusions: This inexpensive and safe drug should be incorporated into trauma clinical practice guidelines and treatment protocols. Further research on possible alternate mechanisms of action and dosing regimens for TXA should be undertaken. Concurrent to these endeavors, TXA should be adopted for use in bleeding trauma patients because it is the only drug with prospective clinical evidence to support this application. C1 [Cap, Andrew P.; Baer, David G.; Orman, Jean A.; Aden, James; Ryan, Kathy; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cap, AP (reprint author), USA, Inst Surg Res, Bldg 3611, Ft Sam Houston, TX 78234 USA. EM andre.p.cap@us.army.mil FU U.S. Army FX Supported by U.S. Army. NR 43 TC 32 Z9 34 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S9 EP S14 DI 10.1097/TA.0b013e31822114af PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900003 PM 21795884 ER PT J AU Cap, AP Spinella, PC AF Cap, Andrew Peter Spinella, Philip C. TI Severity of Head Injury Is Associated With Increased Risk of Coagulopathy in Combat Casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Traumatic brain injury; Coagulopathy; Combat; Trauma; Mortality ID TRAUMATIC BRAIN-INJURY; PROTHROMBIN COMPLEX CONCENTRATE; PARTIAL THROMBOPLASTIN TIME; FIBRINOGEN CONCENTRATE; HYPERCOAGULABLE STATE; THROMBOELASTOGRAPHY; HYPOPERFUSION; MANAGEMENT; INDICATOR AB Background: Traumatic brain injury (TBI) is believed to cause more profound trauma-induced coagulopathy than other injuries of comparable severity. This has not been reported in a large series of combat casualties in which penetrating injuries predominate. Methods: Among US combat casualties severely injured in Iraq and Afghanistan who received transfused blood products, isolated TBI patients (head Abbreviated Injury Score [AIS] >= 3 and all other AIS <2) were compared with non-TBI patients (head AIS <= 2 and any other AIS >= 3) to determine the degree to which TBI is associated with coagulopathy as measured by International Normalized Ratio (INR) and to describe characteristics of this population. Stepwise multiple regression analysis was also performed on all US casualties who received transfused blood products to analyze independent predictors of coagulopathy. Results: We compared 117 patients with isolated TBI and 1,492 patients with non-TBI injuries. Admission INR was significantly higher in TBI patients. There were no differences in age, admission base deficit, systolic or diastolic blood pressure, or hemoglobin. On stepwise multiple regression, base deficit, Glasgow Coma Scale, and head AIS score were independently associated with increased coagulopathy as measured by INR. Conclusion: Patients with severe combat-related trauma and isolated TBI had worse coagulopathy than non-TBI patients. Base deficit, Glasgow Coma Scale, and severity of head injury, as reflected by head AIS, are independently associated with increased coagulopathy as measured by INR. C1 [Cap, Andrew Peter; Spinella, Philip C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cap, AP (reprint author), USA, Inst Surg Res, Bldg 3611, Ft Sam Houston, TX 78234 USA. EM Andre.P.Cap@us.army.mil FU US Army FX Supported by the US Army. NR 26 TC 19 Z9 20 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S78 EP S81 DI 10.1097/TA.0b013e3182218cd8 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900013 PM 21795882 ER PT J AU Convertino, VA Moulton, SL Grudic, GZ Rickards, CA Hinojosa-Laborde, C Gerhardt, RT Blackbourne, LH Ryan, KL AF Convertino, Victor A. Moulton, Steven L. Grudic, Gregory Z. Rickards, Caroline A. Hinojosa-Laborde, Carmen Gerhardt, Robert T. Blackbourne, Lorne H. Ryan, Kathy L. TI Use of Advanced Machine-Learning Techniques for Noninvasive Monitoring of Hemorrhage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Lower body negative pressure; Shock; Medical monitoring ID BODY NEGATIVE-PRESSURE; OPERATION-IRAQI-FREEDOM; CENTRAL HYPOVOLEMIA; EARLY INDICATOR; BLOOD-PRESSURE; STROKE VOLUME; ORTHOSTATIC INTOLERANCE; COMBAT CASUALTIES; OXYGEN-SATURATION; CARDIAC-OUTPUT AB Background: Hemorrhagic shock is a leading cause of death in both civilian and battlefield trauma. Currently available medical monitors provide measures of standard vital signs that are insensitive and nonspecific. More important, hypotension and other signs and symptoms of shock can appear when it may be too late to apply effective life-saving interventions. The resulting challenge is that early diagnosis is difficult because hemorrhagic shock is first recognized by late-responding vital signs and symptoms. The purpose of these experiments was to test the hypothesis that state-of-the-art machine-learning techniques, when integrated with novel non-invasive monitoring technologies, could detect early indicators of blood volume loss and impending circulatory failure in conscious, healthy humans who experience reduced central blood volume. Methods: Humans were exposed to progressive reductions in central blood volume using lower body negative pressure as a model of hemorrhage until the onset of hemodynamic decompensation. Continuous, noninvasively measured hemodynamic signals were used for the development of machine-learning algorithms. Accuracy estimates were obtained by building models using signals from all but one subject and testing on that subject. This process was repeated, each time using a different subject. Results: The model was 96.5% accurate in predicting the estimated amount of reduced central blood volume, and the correlation between predicted and actual lower body negative pressure level for hemodynamic decompensation was 0.89. Conclusions: Machine modeling can accurately identify reduced central blood volume and predict impending hemodynamic decompensation (shock onset) in individuals. Such a capability can provide decision support for earlier intervention. C1 [Convertino, Victor A.; Hinojosa-Laborde, Carmen; Gerhardt, Robert T.; Blackbourne, Lorne H.; Ryan, Kathy L.] USA, Inst Surg Res, Tact Combat Casualty Care TCCC Res Program, Ft Sam Houston, TX 78234 USA. [Moulton, Steven L.] Univ Colorado, Sch Med, Dept Surg, Aurora, CO USA. [Grudic, Gregory Z.] Flashback Technol LLC, Boulder, CO USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, Tact Combat Casualty Care TCCC Res Program, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU United States Army Medical Research and Materiel Command FX Supported by funding from the United States Army Medical Research and Materiel Command Combat Casualty Care Research Program and the Small Business Innovative Research program. NR 55 TC 32 Z9 32 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S25 EP S32 DI 10.1097/TA.0b013e3182211601 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900005 PM 21795890 ER PT J AU Eastridge, BJ Hardin, M Cantrell, J Oetjen-Gerdes, L Zubko, T Mallak, C Wade, CE Simmons, J Mace, J Mabry, R Bolenbaucher, R Blackbourne, LH AF Eastridge, Brian J. Hardin, Mark Cantrell, Joyce Oetjen-Gerdes, Lynne Zubko, Tamara Mallak, Craig Wade, Charles E. Simmons, John Mace, James Mabry, Robert Bolenbaucher, Rose Blackbourne, Lorne H. TI Died of Wounds on the Battlefield: Causation and Implications for Improving Combat Casualty Care SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Military; War; Combat; Injury; Trauma; Died of wounds; Survivability ID OPERATION-IRAQI-FREEDOM; DAMAGE CONTROL RESUSCITATION; CLOT-INDUCING MINERALS; 753 CONSECUTIVE DEATHS; LEVEL TRAUMA CENTER; MAJOR LIMB TRAUMA; INJURY PREVENTION; TOPICAL TREATMENT; ENDURING-FREEDOM; HOSPITAL DEATHS AB Background: Understanding the epidemiology of death after battlefield injury is vital to combat casualty care performance improvement. The current analysis was undertaken to develop a comprehensive perspective of deaths that occurred after casualties reached a medical treatment facility. Methods: Battle injury died of wounds (DOW) deaths that occurred after casualties reached a medical treatment facility from October 2001 to June 2009 were evaluated by reviewing autopsy and other postmortem records at the Office of the Armed Forces Medical Examiners (OAFME). A panel of military trauma experts classified the injuries as nonsurvivable (NS) or potentially survivable (PS), in consultation with an OAFME forensic pathologist. Data including demographics, mechanism of injury, physiologic and laboratory variables, and cause of death were obtained from the Joint Theater Trauma Registry and the OAFME Mortality Trauma Registry. Results: DOW casualties (n = 558) accounted for 4.56% of the nonreturn to duty battle injuries over the study period. DOW casualties were classified as NS in 271 (48.6%) cases and PS in 287 (51.4%) cases. Traumatic brain injury was the predominant injury leading to death in 225 of 271 (83%) NS cases, whereas hemorrhage from major trauma was the predominant mechanism of death in 230 of 287 (80%) PS cases. In the hemorrhage mechanism PS cases, the major body region bleeding focus accounting for mortality were torso (48%), extremity (31%), and junctional (neck, axilla, and groin) (21%). Fifty-one percent of DOW casualties presented in extremis with cardiopulmonary resuscitation upon presentation. Conclusions: Hemorrhage is a major mechanism of death in PS combat injuries, underscoring the necessity for initiatives to mitigate bleeding, particularly in the prehospital environment. C1 [Eastridge, Brian J.; Hardin, Mark; Wade, Charles E.; Simmons, John; Mace, James; Mabry, Robert; Bolenbaucher, Rose; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cantrell, Joyce; Oetjen-Gerdes, Lynne; Zubko, Tamara; Mallak, Craig] Off Armed Forces Med Examiner, Rockville, MD USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 57 TC 133 Z9 137 U1 5 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S4 EP S8 DI 10.1097/TA.0b013e318221147b PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900002 PM 21795876 ER PT J AU Fang, R Allan, PF Womble, SG Porter, MT Sierra-Nunez, J Russ, RS Dorlac, GR Benson, C Oh, JS Wanek, SM Osborn, EC Silvey, SV Dorlac, WC AF Fang, Raymond Allan, Patrick F. Womble, Shannon G. Porter, Morris T. Sierra-Nunez, Johana Russ, Richard S. Dorlac, Gina R. Benson, Clayne Oh, John S. Wanek, Sandra M. Osborn, Erik C. Silvey, Stephen V. Dorlac, Warren C. TI Closing the "Care in the Air" Capability Gap for Severe Lung Injury: The Landstuhl Acute Lung Rescue Team and Extracorporeal Lung Support SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casuality Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL DE Acute respiratory distress syndrome; Aeromedical evacuation; Extracorporeal membrane oxygenation; High-frequency ventilation; Military medicine ID FREQUENCY PERCUSSIVE VENTILATION; ACUTE RESPIRATORY-DISTRESS; MEMBRANE-OXYGENATION; IMPROVES OXYGENATION; TRAUMA PATIENTS; STRATEGIES; TRANSPORT; FAILURE; PROSTACYCLIN; SYSTEM AB Background: The success of US Air Force Critical Care Air Transport Teams (CCATT) in transporting critically ill and injured patients enabled changes in military medical force deployment and casualty care practice. Even so, a subset of casualties remains who exceed even CCATT capabilities for movement. These patients led to the creation of the Landstuhl Acute Lung Rescue Team (ALeRT) to close the "care in the air" capability gap. Methods: The ALeRT Registry was queried for the period between November 1, 2005, and June 30, 2010. Additionally, Landstuhl Regional Medical Center critical care patient transfers to host nation medical centers were reviewed for cases using extracorporeal lung support systems. Results: For the review period, US Central Command activated the ALeRT on 40 occasions. The ALeRT successfully evacuated patients on 24 of 27 missions launched (89%). Three patients were too unstable for ALeRT evacuation. Of the 13 remaining activations, four patients died and nine patients improved sufficiently for standard CCATT movement. The ALeRT initiated pumpless extracorporeal lung assistance six times, but only once to facilitate evacuation. Two patients were supported with full extracorporeal membrane oxygenation support after evacuation due to progressive respiratory failure. Conclusions: ALeRT successfully transported 24 casualties from the combat zones to Germany. Without the ALeRT, these patients would have remained in the combat theater as significant consumers of limited deployed medical resources. Pumpless extracorporeal lung assistance is already within the ALeRT armamentarium, but has only been used for one aeromedical evacuation. Modern extracorporeal membrane oxygenation systems hold promise as a feasible capability for aeromedical evacuation. C1 [Fang, Raymond; Womble, Shannon G.; Porter, Morris T.; Sierra-Nunez, Johana; Russ, Richard S.; Benson, Clayne; Oh, John S.; Wanek, Sandra M.; Silvey, Stephen V.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Allan, Patrick F.] Wright Patterson Med Ctr, Wright Patterson AFB, OH USA. [Dorlac, Gina R.; Dorlac, Warren C.] Univ Cincinnati, USAF, Ctr Sustainment Trauma & Readiness Skills, Cincinnati, OH USA. [Osborn, Erik C.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Fang, R (reprint author), Landstuhl Reg Med Ctr, Landstuhl, Germany. EM Raymond.Fang@us.af.mil NR 23 TC 11 Z9 11 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S91 EP S97 DI 10.1097/TA.0b013e3182218f97 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900016 PM 21795885 ER PT J AU Fowler, M Slater, TM Garza, TH Maani, CV DeSocio, PA Hansen, JJ McGhee, LL AF Fowler, Marcie Slater, Terry M. Garza, Thomas H. Maani, Christopher V. DeSocio, Peter A. Hansen, Jacob J. McGhee, Laura L. TI Relationships Between Early Acute Pain Scores, Autonomic Nervous System Function, and Injury Severity in Wounded Soldiers SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Pain score; Combat casualty; ISS; Vital signs ID MULTIPLE INJURIES; ENDURING-FREEDOM; IRAQI FREEDOM; CARE; POLYTRAUMA; MILITARY; OPERATIONS; TRAUMA; WAR AB Background: Acute pain after injury affects the comfort and function of the wounded soldier and the physiology of multiple body systems. In the civilian population, pain alters the function of the autonomic nervous system, causing increased heart rate and blood pressure. However, there are no data regarding the impact of combat-related pain on physiologic responses. This study is a retrospective analysis that examined the relationship of pain and physiologic parameters in injured soldiers. Methods: After Institutional Review Board approval, the Joint Trauma Theater Registry (JTTR) was queried to identify soldiers who had pain scores recorded in the Emergency Department (ED) in theater. Subject data collected from the JTTR included the following: pain score, Injury Severity Score (ISS), blood pressure, heart rate, and respiratory rate. Results: We identified 2,646 soldiers with pain scores recorded in the ED. The pain score was not related to most physiologic parameters measured in the ED. Pain intensity had no correlation with blood pressure or heart rate. However, there were relationships between the pain score and respiratory rate, with patients reporting a pain score of 10 having a slightly higher respiratory rate. Increasing pain scores were also associated with increased ISS (p < 0.001). Conclusions: In contrast to data from civilian patients, early pain scores were not related to heart rate or blood pressure. A pain score of 10 corresponded to an increased respiratory rate. Despite little relationship between pain and injury severity in the civilian population, the increasing ISS was proportional to the pain scale in wounded soldiers. C1 [Fowler, Marcie; Slater, Terry M.; Garza, Thomas H.; Maani, Christopher V.; DeSocio, Peter A.; Hansen, Jacob J.; McGhee, Laura L.] USA, Inst Surg Res, Battlefield Pain Control Project Area, Houston, TX 78234 USA. [Maani, Christopher V.; DeSocio, Peter A.; Hansen, Jacob J.] USA, Dept Anesthesiol, Inst Surg Res, Houston, TX 78234 USA. [Maani, Christopher V.; DeSocio, Peter A.; Hansen, Jacob J.] USA, Burn Ctr, Brooke Army Med Ctr, Houston, TX USA. RP McGhee, LL (reprint author), USA, Inst Surg Res, Battlefield Pain Control Area, 3698 Chambers Pass, Houston, TX 78234 USA. EM laura.mcghee@us.army.mil RI DeSocio, Peter/E-2970-2011 FU US Army Institute of Surgical Research FX Supported by the US Army Institute of Surgical Research Battlefield Pain Control Project Area. NR 24 TC 2 Z9 2 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S87 EP S90 DI 10.1097/TA.0b013e3182218df8 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900015 PM 21795892 ER PT J AU Gerhardt, RT Berry, JA Blackbourne, LH AF Gerhardt, Robert T. Berry, Johnathon A. Blackbourne, Lorne H. TI Analysis of Life-Saving Interventions Performed by Out-of-Hospital Combat Medical Personnel SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Military medicine; War; Emergency medical services; Remote damage control resuscitation; trauma resuscitation ID DAMAGE CONTROL RESUSCITATION; CASUALTY CARE; TRAUMA; MORTALITY; DEATH; WAR AB Background: To analyze casualties from the Camp Eagle Study, focusing on life-saving interventions (LSI) and potentially survivable deaths. Methods: Retrospective cohort of battle casualties from a forward base engaged in urban combat in Central Iraq. Medical support included emergency medicine practitioners and combat medics with advanced training and protocols. LSI were defined as advanced airway, needle or tube thoracostomy, tourniquet, and hypotensive resuscitation with Hetastarch. Cases were assessed retrospectively for notional application of a Remote Damage Control Resuscitation protocol using blood products. Results: Three hundred eighteen subjects were included. The case fatality rate was 7%. "Urgent" (55) or "priority" (88) medical evacuation was required for 45% of casualties. Sixty-one LSI were performed, in most cases by the physician or PA, with 80% on "urgent" and 9% on "priority" casualties, respectively. Among survivors requiring LSI, the percentage actually performed were airway 100%; thoracostomy 100%; tourniquet 100%; hetastarch 100%. Among nonsurvivors, these percentages were 78%, 50%, 100%, and 56%, respectively. Proximate causes of potentially survivable death were delays in airway placement and ventilation (40%), no thoracostomy (20%), and delayed evacuation resulting in hemorrhagic shock (60%). The notional Remote Damage Control Resuscitation protocol would have been appropriate in 15% of "urgent" survivors and in 26% of nonsurvivors. Conclusion: LSI were required by most urgent casualties, and a lack or delay in their performance was associated with increased mortality. Forward deployment of blood components may represent the next addition to LSI if logistical and scope-of-practice issues can be overcome. C1 [Gerhardt, Robert T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Div Emergency Med, San Antonio, TX 78229 USA. [Berry, Johnathon A.] 10th Special Forces Grp Airborne, Ft Carson, CO USA. [Gerhardt, Robert T.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Gerhardt, Robert T.; Blackbourne, Lorne H.] USA, Inst Surg Res, Houston, TX USA. [Gerhardt, Robert T.; Berry, Johnathon A.] Brooke Army Med Ctr, Dept Emergency Med, Houston, TX USA. [Blackbourne, Lorne H.] Brooke Army Med Ctr, Dept Surg, Houston, TX USA. RP Gerhardt, RT (reprint author), 3400 Rawley E Chambers Ave,Bldg 3611, Houston, TX 78234 USA. EM robert.gerhardt@amedd.army.mil NR 16 TC 21 Z9 21 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S109 EP S113 DI 10.1097/TA.0b013e31822190a7 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900019 PM 21795868 ER PT J AU Hospenthal, DR Crouch, HK English, JF Leach, F Pool, J Conger, NG Whitman, TJ Wortmann, GW Robertson, JL Murray, CK AF Hospenthal, Duane R. Crouch, Helen K. English, Judith F. Leach, Fluryanne Pool, Jane Conger, Nicholas G. Whitman, Timothy J. Wortmann, Glenn W. Robertson, Janelle L. Murray, Clinton K. TI Multidrug-Resistant Bacterial Colonization of Combat-Injured Personnel at Admission to Medical Centers After Evacuation From Afghanistan and Iraq SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Infection control; Military; Trauma; Acinetobacter; E. coli; Klebsiella ID INFECTION-CONTROL CHALLENGES; US ARMY SOLDIERS; ACINETOBACTER-BAUMANNII; OPERATIONS; CASUALTIES; RECOVERY; OUTBREAK; TRAUMA; TIME AB Background: Multidrug-resistant organism (MDRO) infections, including those secondary to Acinetobacter (ACB) and extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (Escherichia coli and Klebsiella species) have complicated the care of combat-injured personnel during Operations Iraqi Freedom and Enduring Freedom. Data suggest that the source of these bacterial infections includes nosocomial transmission in both deployed hospitals and receiving military medical centers (MEDCENs). Admission screening for MDRO colonization has been established to monitor this problem and effectiveness of responses to it. Methods: Admission colonization screening of injured personnel began in 2003 at the three US-based MEDCENs receiving the majority of combat-injured personnel. This was extended to Landstuhl Regional Medical Center (LRMC; Germany) in 2005. Focused on ACB initially, screening was expanded to include all MDROs in 2009 with a standardized screening strategy at LRMC and US-based MEDCENs for patients evacuated from the combat zone. Results: Eighteen thousand five hundred sixty of 21,272 patients admitted to the 4 MEDCENs in calendar years 2005 to 2009 were screened for MDRO colonization. Average admission ACB colonization rates at the US-based MEDCENs declined during this 5-year period from 21% (2005) to 4% (2009); as did rates at LRMC (7-1%). In the first year of screening for all MDROs, 6% (171 of 2,989) of patients were found colonized at admission, only 29% (50) with ACB. Fifty-seven percent of patients (98) were colonized with ESBL-producing E. coli and 11% (18) with ESBL-producing Klebsiella species. Conclusions: Although colonization with ACB declined during the past 5 years, there seems to be replacement of this pathogen with ESBL-producing Enterobacteriaceae. C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Crouch, Helen K.] Brooke Army Med Ctr, Infect Control Serv, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.; Wortmann, Glenn W.; Robertson, Janelle L.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA. [English, Judith F.] USN, Bur Med & Surg, Washington, DC USA. [Leach, Fluryanne] Walter Reed Army Med Ctr, Infect Control Serv, Washington, DC 20307 USA. [Wortmann, Glenn W.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Conger, Nicholas G.] Landstuhl Reg Med Ctr, Div Infect Dis, Ramstein AFB, Germany. [Pool, Jane] Landstuhl Reg Med Ctr, Infect Control Div, Ramstein AFB, Germany. [Whitman, Timothy J.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil NR 25 TC 30 Z9 31 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S52 EP S57 DI 10.1097/TA.0b013e31822118fb PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900009 PM 21795879 ER PT J AU Huh, J Stinner, DJ Burns, TC Hsu, JR AF Huh, Jeannie Stinner, Daniel J. Burns, Travis C. Hsu, Joseph R. CA Late Amputation Study Team TI Infectious Complications and Soft Tissue Injury Contribute to Late Amputation After Severe Lower Extremity Trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52nd Annual Meeting of the Society-of-Military-Orthopedic-Surgeons (SOMOS) CY DEC 14-17, 2010 CL Vail, CO SP Soc Mil Orthoped Surg DE Late amputation; Delayed amputation; Limb salvage; Combat ID SEVERE OPEN FRACTURES; LIMB SALVAGE; CURRENT CONFLICTS; TIBIAL FRACTURES; FOLLOW-UP; AFGHANISTAN; IRAQ AB Background: Although most combat-related amputations occur early for unsalvageable injuries, > 15% occur late after reconstructive attempts. Predicting which patients will abandon limb salvage in favor of definitive amputation has not been explored. The purpose of this study was to identify factors contributing to late amputation for type III open tibia fractures sustained in combat. Methods: Operative databases were reviewed to identify all combat-related type III open diaphyseal tibia fractures from March 2003 to September 2007. Patients were categorized based on their definitive treatment: group I, limb salvage; group II, early amputation (< 12 weeks postinjury); group III, late amputation (> 12 weeks postinjury). Injury, treatment, and complication data were extracted from medical records and compared across groups. Results: We identified 213 consecutive fractures, including 166 (77.9%) treated definitively with limb salvage, 36 (16.9%) with early amputation, and 11 (5.2%) with late amputation. There was no difference in fracture severity among the three groups. Before amputation, group III was more likely to use autograft and bone morphogenic protein (27.3%), compared with group I (4.8%) and group II (0%), and was more likely to undergo rotational flap coverage (45.5%), compared with group II (0%). Group III patients had the highest average number of revision surgeries and rate of deep soft tissue infection and were more likely to have osteomyelitis (54.5%) before amputation compared with group I (13.9%) and group II (16.7%). Conclusion: Patients definitively managed with late amputation were more likely to have soft tissue injury requiring flap coverage and have their limb salvage course complicated by infection. C1 [Huh, Jeannie; Stinner, Daniel J.; Burns, Travis C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.; Late Amputation Study Team] USA, Inst Surg Res, San Antonio, TX USA. RP Huh, J (reprint author), Brooke Army Med Ctr, Bldg 3600,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeannie.Huh@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 25 TC 34 Z9 35 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S47 EP S51 DI 10.1097/TA.0b013e318221181d PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900008 PM 21795878 ER PT J AU Kheirabadi, BS Arnaud, F McCarron, R Murdock, AD Hodge, DL Ritter, B Dubick, MA Blackbourne, LH AF Kheirabadi, Bijan S. Arnaud, Francoise McCarron, Richard Murdock, Alan D. Hodge, Douglas L. Ritter, Brandi Dubick, Michael A. Blackbourne, Lorne H. TI Development of a Standard Swine Hemorrhage Model for Efficacy Assessment of Topical Hemostatic Agents SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Hemorrhage model; Hemostatic agent; Combat gauze; Efficacy; Swine ID EXTREMITY ARTERIAL HEMORRHAGES; CLOT-INDUCING MINERALS; SMECTITE GRANULES; GROIN INJURY; LETHAL MODEL; DRESSINGS; COAGULOPATHY; SURVIVAL; GAUZE AB Background: The diverse information of efficacy of hemostatic products, obtained from different military laboratories using different models, has made it difficult to ascertain the true benefit of new hemostatic agents in military medicine. The aim of this study was to recommend a standard hemorrhage model for efficacy testing acceptable by most investigators in the field and avoid contradictory and duplicative efforts by different laboratories. Methods: The swine femoral artery injury model (6-mm arteriotomy) with some modifications was tested to standardize the model. The suggested modifications included no splenectomy, one-time treatment, 30 seconds free bleeding, and 5 L limit for fluid resuscitation. The model was tested with all or some of these modifications in four experimental conditions (n = 5-6 pigs per condition) using Combat Gauze (CG) as control agent. Results: The primary end points including blood pressure, blood loss, and survival rates were modestly changed in the four conditions. The second experimental condition in which bleeding was treated with a single CG with 3-minute compression produced the most suitable results. The average blood loss was 99 mL/kg, and hemostasis was achieved in one-third of the pigs, which led to matching survival rate. Conclusion: A rigorous hemorrhage model was developed for future evaluation of new hemostatic agents and comparison with CG, the current standard of care. This model may not be suitable for testing every agent and some modifications may be necessary for specific applications. Furthermore, laboratory studies using this or similar models must be accompanied by operational testing in the field to confirm the efficacy and practical utility of selected agents when used on the battlefield. C1 [Kheirabadi, Bijan S.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Arnaud, Francoise; McCarron, Richard] USN, Neuro Trauma Dept, Med Res Ctr, Silver Spring, MD USA. [Murdock, Alan D.] USAF, Med Operat Agcy, Lackland AFB, TX USA. [Hodge, Douglas L.; Ritter, Brandi] Def Med Standardizat Board, Ft Detrick, MD USA. RP Kheirabadi, BS (reprint author), 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@us.army.mil FU US Army Medical Research and Materiel Command FX Authors of this article are military service members or employees of the US Government. The funding for this work was provided solely by the US Army Medical Research and Materiel Command. NR 17 TC 16 Z9 17 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S139 EP S146 DI 10.1097/TA.0b013e318221931e PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900024 PM 21795871 ER PT J AU Kochanek, PM Bramlett, H Dietrich, WD Dixon, CE Hayes, RL Povlishock, J Tortella, FC Wang, KKW AF Kochanek, Patrick M. Bramlett, Helen Dietrich, W. Dalton Dixon, C. Edward Hayes, Ronald L. Povlishock, John Tortella, Frank C. Wang, Kevin K. W. TI A Novel Multicenter Preclinical Drug Screening and Biomarker Consortium for Experimental Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review ID SPINAL-CORD-INJURY; ALPHA-II-SPECTRIN; DELAYED MINOCYCLINE TREATMENT; INCREASES BCL-2 EXPRESSION; CEREBRAL-BLOOD-FLOW; AXONAL INJURY; CELL-DEATH; RAT MODEL; LITHIUM TREATMENT; BREAKDOWN PRODUCTS C1 [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Crit Care Med & Anesthesiol, Pittsburgh, PA 15260 USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15260 USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Clin & Translat Sci, Pittsburgh, PA 15260 USA. [Bramlett, Helen; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Wang, Kevin K. W.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Alachua, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA. [Povlishock, John] Virginia Commonwealth Univ, Sch Med, Commonwealth Ctr Study Brain Injury, Dept Anat & Neurobiol, Richmond, VA USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Combat Casualty Care Res Program Manager Brain Tr, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Gainesville, FL 32611 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, 3434 5th Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu RI Kochanek, Patrick/D-2371-2015; OI Kochanek, Patrick/0000-0002-2627-913X; Wang, Kevin/0000-0002-9343-6473 FU United States Army [W81XWH-10-1-0623] FX Supported by the United States Army grant W81XWH-10-1-0623. NR 101 TC 23 Z9 25 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S15 EP S24 DI 10.1097/TA.0b013e31822117fe PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900004 PM 21795873 ER PT J AU Lucca, JJD Simovic, M Li, YS Moratz, C Falabella, M Tsokos, GC AF Lucca, Jurandir J. Dalle Simovic, Milomir Li, Yansong Moratz, Chantal Falabella, Michael Tsokos, George C. TI Decay-Accelerating Factor Mitigates Controlled Hemorrhage-Instigated Intestinal and Lung Tissue Damage and Hyperkalemia in Swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Ischemia; Resuscitation; Complement system; Decay accelerating factor; Hemorrhage ID MULTIPLE ORGAN FAILURE; INFLAMMATORY RESPONSE; COMPLEMENT ACTIVATION; TRAUMA; RESUSCITATION; INJURY; ISCHEMIA; KINASES; SEPSIS; SHOCK AB Background: Activation of complement system has been associated with tissue injury after hemorrhage and resuscitation in rats and swine. This study investigated whether administration of human recombinant decay-accelerating factor (DAF; a complement regulatory protein that inhibits classical and alternative pathways) reduces tissue damage in a porcine model of hemorrhagic shock. Methods: Male Yorkshire swine assigned to four groups were subjected to controlled, isobaric hemorrhage over 15 minutes to a target mean arterial pressure of 35 mm Hg. Hypotension was maintained for 20 minutes followed by a bolus intravenous injection of DAF or vehicle and then animals were observed for 200 minutes. Blood chemistry and physiologic parameters were recorded. Tissue samples from lung and small intestine were subjected to histopathological evaluation and detection of tissue deposition of complement proteins by immunohistochemistry and Western blot analyses. Results: Administration of DAF significantly reduced intestinal and lung tissue damage in a dose-dependent manner (5, 25, and 50 mu g/kg). In addition, DAF treatment improved hemorrhage-induced hyperkalemia. The protective effects of DAF appear to be related to its ability to reduce tissue complement activation and deposition on affected tissues. Conclusions: DAF treatment decreased tissue complement activation and deposition in hemorrhaged animals and attenuated tissue damage at 200 minutes after treatment. The observed beneficial effects of DAF treatment on tissue injury after 20 minutes of severe hypotension presents an attractive model of small volume resuscitation, particularly in situations with a restrictive medical logistical footprint such as far-forward access to first responders in the battlefield or in remote rural or mountainous environments. C1 [Lucca, Jurandir J. Dalle; Simovic, Milomir; Li, Yansong; Falabella, Michael] USA, ImmunoModulat Trauma Program, Inst Surg Res, Houston, TX 78234 USA. [Moratz, Chantal] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA. RP Lucca, JJD (reprint author), USA, ImmunoModulat Trauma Program, Inst Surg Res, 3400 Rawley E Chambers Ave, Houston, TX 78234 USA. EM Jurandir.dallelucca@us.army.mil FU United States Army Medical Research and Materiel Command FX Supported by United States Army Medical Research and Materiel Command. NR 24 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S151 EP S160 DI 10.1097/TA.0b013e318221aa4c PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900026 ER PT J AU Maani, CV Hoffman, HG Morrow, M Maiers, A Gaylord, K McGhee, LL DeSocio, PA AF Maani, Christopher V. Hoffman, Hunter G. Morrow, Michelle Maiers, Alan Gaylord, Kathryn McGhee, Laura L. DeSocio, Peter A. TI Virtual Reality Pain Control During Burn Wound Debridement of Combat-Related Burn Injuries Using Robot-Like Arm Mounted VR Goggles SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat; Analgesia; Burn pain; Wound care; Virtual reality ID DISTRACTION; MORPHINE AB Background: This is the first controlled study to explore whether adjunctive immersive virtual reality (VR) can reduce excessive pain of soldiers with combat-related burn injuries during wound debridement. Methods: Patients were US soldiers burned in combat attacks involving explosive devices in Iraq or Afghanistan. During the same wound care session using a within-subject experimental design, 12 patients received half of their severe burn wound cleaning procedure (similar to 6 minutes) with standard of care pharmacologies and half while in VR (treatment order randomized). Three 0 to 10 Graphic Rating Scale pain scores for each of the treatment conditions served as the primary variables. Results: Patients reported significantly less pain when distracted with VR. "Worst pain" (pain intensity) dropped from 6.25 of 10 to 4.50 of 10. "Pain unpleasantness" ratings dropped from "moderate" (6.25 of 10) to "mild" (2.83 of 10). "Time spent thinking about pain" dropped from 76% during no VR to 22% during VR. Patients rated "no VR" as "no fun at all" (<1 of 10) and rated VR as "pretty fun" (7.5 of 10). Follow-up analyses showed VR was especially effective for the six patients who scored 7 of 10 or higher (severe to excruciating) on the "worst pain" (pain intensity) ratings. Conclusions: These preliminary results provide the first evidence from a controlled study that adjunctive immersive VR reduced pain of patients with combat-related burn injuries during severe burn wound debridement. Pain reduction during VR was greatest in patients with the highest pain during no VR. These patients were the first to use a unique custom robot-like arm mounted VR goggle system. C1 [Maani, Christopher V.; Morrow, Michelle; Maiers, Alan; Gaylord, Kathryn; McGhee, Laura L.; DeSocio, Peter A.] USA, Inst Surg Res, Brooke Army Med Ctr, Houston, TX USA. [Hoffman, Hunter G.] Univ Washington, Seattle, WA 98195 USA. RP Maani, CV (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, Houston, TX USA. EM christopher.maani@us.army.mil; hunthoff@uw.edu RI DeSocio, Peter/E-2970-2011 FU U.S. Army Institute of Surgical Research; Gustavus and Louise Pfieffer Research Foundation; Scan Design Foundation; NIH [NIH HD40954-01, 1R01AR054115-01A1, R01GM042725-17A1] FX Supported by U.S. Army Institute of Surgical Research. Hoffman's time was funded with help from the Gustavus and Louise Pfieffer Research Foundation, the Scan Design Foundation by Inger and Jens Bruun, and the following NIH grants to Drs. Patterson and Sharar at the UW: NIH HD40954-01, 1R01AR054115-01A1, R01GM042725-17A1. NR 25 TC 21 Z9 23 U1 3 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S125 EP S130 DI 10.1097/TA.0b013e31822192e2 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900022 PM 21795888 ER PT J AU Maani, CV DeSocio, PA Jansen, RK Merrell, JD McGhee, LL Young, A Williams, JF Tyrell, K Jackson, BA Serio-Melvin, ML Blackbourne, LH Renz, EM AF Maani, Christopher V. DeSocio, Peter A. Jansen, Richard K. Merrell, Jason D. McGhee, Laura L. Young, Alan Williams, James F. Tyrell, Katie Jackson, Bonnie A. Serio-Melvin, Maria L. Blackbourne, Lorne H. Renz, Evan M. TI Use of Ultra Rapid Opioid Detoxification in the Treatment of US Military Burn Casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Rapid opioid detoxification; Opioid dependence; Rehabilitation; Narcotic; Opioid ID GENERAL-ANESTHESIA; ANTAGONIST DETOXIFICATION; HEROIN DETOXIFICATION; DEPENDENCE; TRIAL; WITHDRAWAL; METHADONE AB Background: The purpose of this case series was to review the management of burn patients who requested ultrarapid opioid detoxification under anesthesia after extended duration of narcotic use for chronic pain related to burn injury. Methods: The treatment plan of six opioid-dependent burn patients was analyzed to assess the effectiveness of our detoxification practice to date. Demographic and clinical information was used to characterize the patient population served: age, burn size, injury severity, duration of narcotic use before detoxification intervention, and length of hospitalization stay. Daily narcotic consumption, in morphine equivalent units, was noted both before and after detoxification. Results: Six burn patients (average age, 31 years) underwent detoxification at the Burn Center during a hospitalization lasting between 1 day and 2 days. Average burn size was 38% total body surface area (range, 17-65); average Injury Severity Score was 30 (range, 25-38). Mean duration of narcotic use was 672 days (range, 239-1,156 days); average use of narcotics at time of detoxification was >200 units daily. Mean outpatient consumption for opioids after the intervention was minimal (<25 units/d). No complications were noted during any procedures. Conclusions: The results of ultrarapid opioid detoxification under anesthesia suggests that it is safe and effective for treating opioid addiction in military burn casualties when a coordinated, multidisciplinary approach is used. Safety and effectiveness to date validate current practice and supports incorporation into clinical practice guidelines. Further clinical research is warranted to identify those patients who may benefit most from detoxification and to determine the timing of such treatment. C1 [Maani, Christopher V.; DeSocio, Peter A.; Jansen, Richard K.; McGhee, Laura L.; Young, Alan; Williams, James F.; Tyrell, Katie; Jackson, Bonnie A.; Serio-Melvin, Maria L.; Blackbourne, Lorne H.; Renz, Evan M.] USA, Inst Surg Res, Houston, TX 78234 USA. [Maani, Christopher V.; DeSocio, Peter A.; Jansen, Richard K.; McGhee, Laura L.; Young, Alan; Williams, James F.; Tyrell, Katie; Jackson, Bonnie A.; Serio-Melvin, Maria L.; Blackbourne, Lorne H.; Renz, Evan M.] Brooke Army Med Ctr, Burn Ctr, Houston, TX 78234 USA. [Merrell, Jason D.] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Anesthesiol, San Antonio, TX USA. [Maani, Christopher V.; Blackbourne, Lorne H.; Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Maani, CV (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Houston, TX 78234 USA. EM Christopher.Maani@us.army.mil RI DeSocio, Peter/E-2970-2011 NR 18 TC 5 Z9 5 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S114 EP S119 DI 10.1097/TA.0b013e3182219209 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900020 PM 21795869 ER PT J AU Masini, BD Owens, BD Hsu, JR Wenke, JC AF Masini, Brendan D. Owens, Brett D. Hsu, Joseph R. Wenke, Joseph C. TI Rehospitalization After Combat Injury SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Rehospitalization; Combat trauma; Resource utilization ID OPERATION ENDURING FREEDOM; TRAUMA RECOVERY PROJECT; IRAQI FREEDOM; RECONSTRUCTION; COMPLICATIONS; AMPUTATION; CASUALTIES; 12-MONTH; OUTCOMES; WOUNDS AB Background: Frequency of rehospitalization and associated resource requirements are unknown for combat casualties. Differences may also exist in readmission rates for injuries to separate body regions. This study investigates rehospitalization of combat casualties with a hypothesis that extremity injuries cause the greatest number of readmissions and require the greatest resources to treat. Methods: A Department of Defense database was queried for hospital admissions of a previously published cohort of service members initially wounded in Iraq and Afghanistan between October 2001 and January 2005. Cohort admission data were collected from October 2001 to February 2008. Body region injured was assigned using International Classification of Diseases Ninth Edition primary diagnosis codes. Resource utilization was calculated using the 2008 Department of Defense billing calculator. Results: Our cohort consisted of 1,337 service members with 2,899 admissions. Three hundred forty-one service members had 670 readmissions. Of rehospitalizations, 64% were for extremity injuries making up 66% of all rehospitalization days. Seventy percent of service members injured had at least one admission for extremity injury. Wound debridement made up 12% of all readmissions, and 92% of these were for extremity injuries. The estimated cost of rehospitalization for extremity injuries for this conflict to date is $139 million. Conclusions: Extremity injuries have been shown to result in the greatest long-term disability and require the greatest resource utilization during initial treatment. This study demonstrates that they also are the most frequent cause of rehospitalization and require the greatest resource utilization during rehospitalization. C1 [Masini, Brendan D.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Owens, Brett D.] Keller Army Community Hosp, West Point, NY USA. [Hsu, Joseph R.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Masini, BD (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Brendan.Masini@amedd.army.mil NR 22 TC 11 Z9 11 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S98 EP S102 DI 10.1097/TA.0b013e3182218fbc PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900017 PM 21795886 ER PT J AU Murray, CK Wilkins, K Molter, NC Li, F Yu, L Spott, MA Eastridge, B Blackbourne, LH Hospenthal, DR AF Murray, Clinton K. Wilkins, Kenneth Molter, Nancy C. Li, Fang Yu, Lily Spott, Mary Ann Eastridge, Brian Blackbourne, Lorne H. Hospenthal, Duane R. TI Infections Complicating the Care of Combat Casualties During Operations Iraqi Freedom and Enduring Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat; Infection; Afghanistan; War; Trauma registry ID TRAUMA PATIENTS; CONTROL CHALLENGES; MILITARY; INJURIES; AFGHANISTAN; EPIDEMIOLOGY; EXPERIENCE; VIETNAM; DEATH; WAR AB Background: Continued assessment of casualty complications, such as infections, enables the development of evidence-based guidelines to mitigate excess morbidity and mortality. We examine the Joint Theater Trauma Registry (JTTR) for infections and potential risk factors, such as transfusions, among Iraq and Afghanistan trauma patients. Methods: JTTR entries from deployment-related injuries with completed records between March 19, 2003, and April 13, 2009, were evaluated using International Classification of Diseases-9 codes for infections defined by anatomic/clinical syndromes and/or type of infecting organisms. Risk factors included mechanisms of injury, patient demographics, Injury Severity Score (ISS), and transfusion, including massive transfusions (>= 10 units of packed red blood cells). Results: We reviewed 16,742 patients entries (15,021 from Operation Iraqi Freedom (9,883 battle injuries [BI]) and 1,721 from Operation Enduring Freedom (1,090 BI). A total of 96.6% were men and 77.6% were Army personnel. The majority of BI were due to explosive devices (36.3%). There were 921 patients (5.5%) who had one or more infection codes with only 111 (0.6%) recorded deaths (16 with infections). Infections were commonly gram-negative bacteria (47.6%) involving skin/wound infections (26.7%), and lung infections (14.6%). Risk factors or associations that were most notable in univariate and multivariate analysis were calendar year of trauma, ISS, and pattern of injury. Conclusion: The 5.5% infection rate is consistent with previous military and civilian trauma literature; however, with the limitations of the JTTR, the infection rate is likely an underrepresentation due to inadequate level V and long-term infectious complications data. Combat operational trauma is primarily associated with gram-negative bacteria typically involving infections of wounds or other skin structures and lung infections such as pneumonia. They are commonly linked with higher ISS and injuries to the head, neck, and face. C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Wilkins, Kenneth; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wilkins, Kenneth] Infect Dis Clin Res Program, Bethesda, MD USA. [Molter, Nancy C.; Spott, Mary Ann; Eastridge, Brian; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Li, Fang; Yu, Lily] US Mil HIV Res Program, Data Coordinating & Anal Ctr, Silver Spring, MD USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil FU U.S. Army Institute of Surgical Research (USAISR) Joint Theater Trauma System (JTTS); Infectious Disease Clinical Research Program (IDCRP) [IDCRP-006]; Department of Defense (DoD); National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Supported by the U.S. Army Institute of Surgical Research (USAISR) Joint Theater Trauma System (JTTS) and the Infectious Disease Clinical Research Program (IDCRP) grant IDCRP-006, a Department of Defense (DoD) program executed through the Uniformed Services University, and in part by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 26 TC 27 Z9 27 U1 5 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S62 EP S73 DI 10.1097/TA.0b013e3182218c99 PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900011 PM 21795880 ER PT J AU Owens, JG Blair, JA Patzkowski, JC Blanck, RV Hsu, JR AF Owens, Johnny G. Blair, James A. Patzkowski, Jeanne C. Blanck, Ryan V. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Return to Running and Sports Participation After Limb Salvage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52nd Annual Meeting of the Society-of-Military-Orthopedic-Surgeons (SOMOS) CY DEC 14-17, 2010 CL Vail, CO SP Soc Mil Orthoped Surg DE Limb salvage; Combat wounds; Ankle-foot orthosis; Trauma rehabilitation ID LOWER-EXTREMITY TRAUMA; PHYSICAL-THERAPY; INJURIES; AMPUTATION; PATIENT; COMBAT; FOOT; GAIT AB Background: The ability to return to running and sports participation after lower extremity limb salvage has not been well documented previously. Although the ability to ambulate without pain or assistive devices is generally a criteria for a good limb salvage outcome, many patients at our institution have expressed a desire to return to a more athletic lifestyle to include running and sports participation. The purpose of this study was to investigate the types of athletic endeavors our high-energy lower extremity trauma patients were able to pursue after limb salvage. Methods: We retrospectively analyzed lower extremity limb salvage patients who were at least 12 weeks status after external fixation removal and participated in our limb salvage return-to-running clinical pathway. Patients were rehabilitated to their highest functional level through a sports medicine-based approach. A custom energy-storing ankle-foot orthosis was implemented to help augment plantarflexion strength in conjunction with running gait retraining. Results: The first 10 patients to complete the clinical pathway were identified. All patients were treated at the same institution by the same orthopedic surgeon and physical therapist. Eight patients have returned to running, and 10 patients have returned to weight-lifting. Seven patients have returned to cycling, three have returned to golf, three to basketball, and two to softball. Two patients have completed a mini-triathlon. Conclusion: Aggressive rehabilitation, an energy-storing ankle-foot orthosis, and running gait retraining can restore an active recreational lifestyle to patients who have undergone lower extremity limb salvage. C1 [Blair, James A.; Patzkowski, Jeanne C.] San Antonio Mil Med Ctr, Orthopaed Surg Serv, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Blanck, Ryan V.] San Antonio Mil Med Ctr, Ctr Intrepid, Prosthet & Orthot Dept, Ft Sam Houston, TX 78234 USA. USA, Skeletal Trauma Res Consortium STReC, Inst Surg Res, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. RP Blair, JA (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg Serv, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM james.blair@amedd.army.mil NR 15 TC 29 Z9 29 U1 1 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S120 EP S124 DI 10.1097/TA.0b013e3182219225 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900021 PM 21795870 ER PT J AU Simmons, JW White, CE Ritchie, JD Hardin, MO Dubick, MA Blackbourne, LH AF Simmons, John W. White, Christopher E. Ritchie, John D. Hardin, Mark O. Dubick, Michael A. Blackbourne, Lorne H. TI Mechanism of Injury Affects Acute Coagulopathy of Trauma in Combat Casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Coagulopathy; Massive transfusion; Trauma; Blunt; Penetrating ID SEVERITY SCORE; PROTEIN-C; COAGULATION; RESUSCITATION; TEMPERATURE; HYPOTHERMIA; HYPOPERFUSION; MORTALITY; REGISTRY; IMPACT AB Background: Recent evidence suggests trauma involving total body tissue damage increases the acute coagulopathy of trauma (ACOT) by various mechanisms, especially in massive transfusion (MT). Our hypothesis was that MT patients injured by explosion will have a higher international normalization ratio (INR) at admission than MT patients injured by gunshot wound (GSW). Methods: A retrospective review was performed on US military injured in Operation Iraqi Freedom/Operation Enduring Freedom from March 2003 to September 2008, who received MT (>10 red blood cells in 24 hours) and had an INR on admission. Two cohorts were created based on mechanism. Admission vital signs, labs, transfusion, and mortality data were compared. Results: Seven hundred fifty-one MT patients were identified. Four hundred fifty patients had admission INR and were injured by either GSW or explosion. Patients demonstrated similar injury severity scale and Glasgow Coma Scale. Patients injured by explosion presented with higher INR, greater base deficit, and more tachycardic than patients injured by GSW. Transfusion of blood products was similar between both groups. Conclusions: The primary finding of this study is that patients injured by explosion presented with a higher INR than those injured by GSW, even with similar injury severity scale. In addition, patients injured by explosion presented more tachycardic and with a greater base deficit. These findings support the theory that ACOT is affected by the amount of tissue injured. Further research is needed into the pathophysiology of ACOT because this may impact care of patients with total body tissue damage/hypoxia and improve the treatment of their coagulopathy while minimizing the attendant complications. C1 [Simmons, John W.; White, Christopher E.; Ritchie, John D.; Hardin, Mark O.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. RP Simmons, JW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.simmons@amedd.army.mil NR 23 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S74 EP S77 DI 10.1097/TA.0b013e3182218cc1 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900012 PM 21795881 ER PT J AU Simmons, JW White, CE Eastridge, BJ Holcomb, JB Perkins, JG Mace, JE Blackbourne, LH AF Simmons, John W. White, Christopher E. Eastridge, Brian J. Holcomb, John B. Perkins, Jeremy G. Mace, James E. Blackbourne, Lorne H. TI Impact of Improved Combat Casualty Care on Combat Wounded Undergoing Exploratory Laparotomy and Massive Transfusion SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Trauma; Hemorrhage; Massive transfusion; Damage control resuscitation ID INJURY SEVERITY SCORE; TRAUMA PATIENTS; TOURNIQUET USE; FACTOR VIIA; SURGERY; FREEDOM; SYSTEM; IRAQ AB Studies have shown decreased mortality after improvements in combat casualty care, including increased fresh frozen plasma (FFP): red blood cell (RBC) ratios. The objective was to evaluate the evolution and impact of improved combat casualty care at different time periods of combat operations. Methods: A retrospective review was performed at one combat support hospital in Iraq of patients requiring both massive transfusion (>= 10 units RBC in 24 hours) and exploratory laparotomy. Patients were divided into two cohorts based on year wounded: C1 between December 2003 and June 2004, and C2 between September 2007 and May 2008. Admission data, amount of blood products and fluid transfused, and 48 hour mortality were compared. Statistical significance was set at p < 0.05. Results: There was decreased mortality in C2 (47% vs. 20%). Patients arrived warmer with higher hemoglobin. They were transfused more RBC and FFP in the emergency department (5 units +/- 3 units vs. 2 units +/- 2 units; 3 units +/- 2 units vs. 0 units +/- 1 units, respectively) and received less crystalloid in operating room (3.3 L +/- 2.2 L vs. 8.5 L +/- 4.9 L). The FFP: RBC ratio was also closer to 1:1 in C2 (0.775 +/- 0.32 vs. 0.511 +/- 0.21). Conclusions: The combination of improved prehospital care, trauma systems approach, performance improvement projects, and improved transfusion or resuscitation practices have led to a 50% decrease in mortality for this critically injured population. We are now transfusing blood products in a ratio more consistent with 1 FFP to 1 RBC. Simultaneously, crystalloid use has decreased by 61%, all of which is consistent with hemostatic resuscitation principles. C1 [Simmons, John W.; White, Christopher E.; Eastridge, Brian J.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Houston, Ctr Translat Injury Res, Houston, TX USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Dept Hematol Oncol, Washington, DC 20307 USA. [Mace, James E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Simmons, JW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.simmons@amedd.army.mil NR 23 TC 14 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S82 EP S86 DI 10.1097/TA.0b013e3182218ddb PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900014 PM 21795883 ER PT J AU Stinner, DJ Waterman, SM Masini, BD Wenke, JC AF Stinner, Daniel J. Waterman, Scott M. Masini, Brendan D. Wenke, Joseph C. TI Silver Dressings Augment the Ability of Negative Pressure Wound Therapy to Reduce Bacteria in a Contaminated Open Fracture Model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52nd Annual Meeting of the Society-of-Military-Orthopedic-Surgeons (SOMOS) CY DEC 14-17, 2010 CL Vail, CO SP Soc Mil Orthoped Surg DE Contamination; Infection; Open fracture; Negative pressure; Silver dressing ID VACUUM-ASSISTED CLOSURE AB Background: Despite a lack of evidence supporting their use, silver dressings are often used with negative pressure wound therapy (NPWT). This study investigates the effectiveness of silver dressings to reduce bacteria in contaminated wounds when used with NPWT. Methods: Complex orthopedic wounds were created on the proximal left legs of anesthetized goats. The wounds were inoculated with either a strain of bioluminescent Pseudomonas aeruginosa or Staphylococcus aureus. These bacteria are genetically modified to emit photons, thereby allowing quantification of bacterial concentration with a photon-counting camera system. The wounds were debrided 6 hours after inoculation and were treated with silver impregnated gauze combined with NPWT. Repeat debridements were performed every 48 hours for 6 days. Imaging was performed pre- and postdebridement. These results were compared with standard NPWT controls that used dressings without silver. Results: There were fewer bacteria in the silver groups than the standard NPWT groups at 6 days. In the groups that were inoculated with P. aeruginosa, wounds in the silver group contained 21% +/- 5% of baseline bacterial load compared with 43% +/- 14% in the standard NPWT group. The addition of the silver dressings has a more pronounced effect on Staphylococcus. Wounds in the silver group contained 25% +/- 8% of baseline bacterial load compared with 115% +/- 19% in the standard NPWT group. Conclusions: The use of silver dressings with NPWT is a fairly common practice with limited literature to support its use in contaminated wounds. This study demonstrates that the addition of a silver dressing to NPWT effectively reduces bacteria in contaminated wounds and is more beneficial on the gram-positive bacteria. These data support the use of silver dressings in contaminated wounds, particularly ones contaminated by S. aureus. C1 [Stinner, Daniel J.; Waterman, Scott M.; Masini, Brendan D.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 18 TC 17 Z9 20 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S147 EP S150 DI 10.1097/TA.0b013e318221944a PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900025 PM 21795872 ER PT J AU Therien, SP Nesbitt, ME Duran-Stanton, AM Gerhardt, RT AF Therien, Sean P. Nesbitt, Michael E. Duran-Stanton, Amelia M. Gerhardt, Robert T. TI Prehospital Medical Documentation in the Joint Theater Trauma Registry: A Retrospective Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE War; Combat; Trauma; Registries; US military ID COMBAT CASUALTY CARE; OPERATION IRAQI FREEDOM; OUTCOMES AB Background: Prehospital care of combat casualties is a critical phase of emergency medical practice on the battlefield. The Joint Theater Trauma Registry (JTTR) was developed to standardize a system of data collection for combat casualty care; however, the degree of population and granularity of prehospital data were unknown. Methods: This is a retrospective comparative study of all US military personnel who sustained battle injuries in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). The JTTR was queried for all US military battle casualties from OIF and OEF entered between January 2002 and July 2009 containing any data entered into the prefacility fields. Data were separated based on origination, OIF, or OEF. A comparative analysis was performed. Results: During the period studied, 13,080 (66%) entries into the JTTR were recorded in the category of "Battle Injury" and met study inclusion criteria; 3,187 (24%) battle injury entries contained prehospital data (n = 3,187). The percentage of casualty records containing prehospital data were 18.6% for OEF and 25.4% for OIF (p < 0.01). Conclusion: Both poor population of data points and poor granularity of prehospital data entered into the JTTR were observed. It appears that the volume and quality of reporting of role-I data were better for OIF than OEF for this study period. Further investigations into the obstacles to free flow of role-I casualty clinical data, and the means to mitigate this situation, are warranted. C1 [Therien, Sean P.; Nesbitt, Michael E.] San Antonio Mil Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Duran-Stanton, Amelia M.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert T.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Therien, SP (reprint author), San Antonio Mil Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM sean.therien@us.army.mil NR 21 TC 12 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S103 EP S108 DI 10.1097/TA.0b013e3182218fd7 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900018 PM 21795867 ER PT J AU Tribble, DR Conger, NG Fraser, S Gleeson, TD Wilkins, K Antonille, T Weintrob, A Ganesan, A Gaskins, LJ Li, P Grandits, G Landrum, ML Hospenthal, DR Millar, EV Blackbourne, LH Dunne, JR Craft, D Mende, K Wortmann, GW Herlihy, R McDonald, J Murray, CK AF Tribble, David R. Conger, Nicholas G. Fraser, Susan Gleeson, Todd D. Wilkins, Ken Antonille, Tanya Weintrob, Amy Ganesan, Anuradha Gaskins, Lakisha J. Li, Ping Grandits, Greg Landrum, Michael L. Hospenthal, Duane R. Millar, Eugene V. Blackbourne, Lorne H. Dunne, James R. Craft, David Mende, Katrin Wortmann, Glenn W. Herlihy, Rachel McDonald, Jay Murray, Clinton K. TI Infection-Associated Clinical Outcomes in Hospitalized Medical Evacuees After Traumatic Injury: Trauma Infectious Disease Outcome Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casuality Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL ID INCREASED RESOURCE UTILIZATION; OPERATION-ENDURING-FREEDOM; COMBAT-RELATED INJURIES; BLOOD-TRANSFUSION; IRAQI-FREEDOM; MILITARY; CASUALTIES; CARE; COLONIZATION; AFGHANISTAN C1 [Tribble, David R.; Wilkins, Ken; Weintrob, Amy; Ganesan, Anuradha; Gaskins, Lakisha J.; Li, Ping; Landrum, Michael L.; Millar, Eugene V.; Mende, Katrin; Herlihy, Rachel] Uniformed Serv Univ Hlth Sci USU, Infect Dis Clin Res Program IDCRP, Bethesda, MD USA. [Conger, Nicholas G.] Landstuhl Reg Med Ctr LRMC, Landstuhl, Germany. [Fraser, Susan; Weintrob, Amy; Wortmann, Glenn W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Gleeson, Todd D.; Ganesan, Anuradha; Dunne, James R.] Natl Naval Med Ctr, Bethesda, MD USA. [Antonille, Tanya; Craft, David] Walter Reed Army Inst Res, Silver Spring, MD USA. [Grandits, Greg] Univ Minnesota, Data Anal Ctr DAC, Minneapolis, MN USA. [Landrum, Michael L.; Hospenthal, Duane R.; Mende, Katrin; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [McDonald, Jay] St Louis Vet Adm Med Ctr, St Louis, MO USA. RP Tribble, DR (reprint author), Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dtribble@usuhs.mil FU NIAID NIH HHS [Y1-AI-5072, Y01 AI005072, Y01 AI005072-05] NR 40 TC 40 Z9 43 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S33 EP S42 DI 10.1097/TA.0b013e318221162e PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900006 PM 21795875 ER PT J AU White, JM Cannon, JW Stannard, A Spencer, JR Hancock, H Williams, K Oh, JS Rasmussen, TE AF White, Joseph M. Cannon, Jeremy W. Stannard, Adam Spencer, Jerry R. Hancock, Heather Williams, Ken Oh, John S. Rasmussen, Todd E. TI A Porcine Model for Evaluating the Management of Noncompressible Torso Hemorrhage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casuality Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL DE Noncompressible hemorrhage; Emergency thoracotomy; Combat injury; Large animal model; Vascular injury ID EMERGENCY-DEPARTMENT THORACOTOMY; CARDIAC-ARREST; ABDOMINAL EXSANGUINATION; MASSIVE HEMOPERITONEUM; AORTIC OCCLUSION; STILL USEFUL; SHOCK; RESUSCITATION; INJURY; DAMAGE AB Background: Noncompressible hemorrhage from central vascular injuries remains the leading cause of preventable death in modern combat. This report introduces a large animal model of noncompressible torso hemorrhage, which permits assessment of the various approaches to this problem. Methods: Yorkshire swine were anesthetized and monitoring devices for central aortic pressure, carotid flow, and intracerebral and transcutaneous brain oximetry were applied. Class IV hemorrhagic shock was induced through an iliac arterial injury and animals were subjected to different vascular control methods including thoracic aortic clamping, supraceliac aortic clamping, direct vascular control, and proximal endovascular balloon occlusion. After vascular control, the injury was shunted, and damage control resuscitation was continued. Serum markers, intravenous fluid volumes, and vasopressor requirements were tracked over a subsequent resuscitation period. Postmortem tissue analysis was performed to compare levels of acute ischemic injury between groups. Results: The protocol for animal preparation, hemorrhage volume, open surgical technique, and posthemorrhage resuscitation was developed using four animals. The endovascular approach was developed using two additional animals. After model development, treatment animals subsequently underwent noncompressible hemorrhage with thoracic aortic clamping, supraceliac aortic clamping, direct vascular control, and endovascular aortic occlusion. Premature death occurred in one animal in the direct vascular control group. Conclusion: This study presents a large animal model of class IV hemorrhagic shock from noncompressible hemorrhage, which permits comparison of various vascular control methods to address this challenging problem. Future studies using this model as the standard will allow further development of strategies for the management of noncompressible hemorrhage. C1 [Cannon, Jeremy W.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Stannard, Adam; Spencer, Jerry R.; Williams, Ken] Wilford Hall USAF Med Ctr, Lackland AFB, TX USA. [Hancock, Heather] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Oh, John S.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cannon, JW (reprint author), Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. EM jcannon@massmed.org NR 18 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2011 VL 71 SU 1 BP S131 EP S138 DI 10.1097/TA.0b013e3182219302 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 790RW UT WOS:000292607900023 PM 21795889 ER PT J AU Bester, WT AF Bester, William T. TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 [Bester, William T.] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP II EP III PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100001 ER PT J AU DeFraites, RF AF DeFraites, Robert F. TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 USA, Washington, DC 20310 USA. RP DeFraites, RF (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP V EP V PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100003 ER PT J AU Kirkpatrick, JS AF Kirkpatrick, Jeffrey S. TI The Impact of US Military Operations in Kuwait, Bosnia, and Kosovo (1991-2000) on Environmental Health Surveillance SO MILITARY MEDICINE LA English DT Article AB Deployments of U.S. Forces to the Persian Gulf (1991), Bosnia and Herzegovina (1995), and Kosovo (1999) were associated with diverse, potential environmental exposures. Health effects possibly associated with these exposures were cause for concern among service members, veterans, and military and civilian leaders. A need for the military to effectively respond to these exposures, and more importantly, to assess and mitigate exposures before deployments and to conduct environmental surveillance during deployments was identified. The Department of Defense encountered many obstacles in dealing with the exposures of 1991. Even though these obstacles were being identified, and in some cases, addressed, responses to historical exposure concerns continued to be reactive. In 1996, efforts were intensified to improve policy and doctrine, field sampling equipment, risk assessment processes, geographic information systems, and other tools needed to effectively identify and reduce the impact of exposures before troops deploy and to conduct environmental surveillance while deployed. Success in these efforts resulted in a comprehensive, planned approach being implemented to address environmental health concerns during the 1999 Kosovo deployment. C1 USA, Inst Publ Hlth, ATTN MCHB IP R, Aberdeen Proving Ground, MD 21010 USA. RP Kirkpatrick, JS (reprint author), USA, Inst Publ Hlth, ATTN MCHB IP R, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 33 TC 3 Z9 3 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP 41 EP 45 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100012 PM 21916329 ER PT J AU Heller, JM AF Heller, Jack M. TI Oil Well Fires of Operation Desert Storm - Defining Troop Exposures and Determining Health Risks SO MILITARY MEDICINE LA English DT Article ID GULF-WAR VETERANS; SMOKE; ASTHMA; MODEL AB During Operation Desert Storm, in February 1991, Iraqi troops began burning Kuwaiti oil wells. Almost immediately there was concern about possible adverse health effects in U.S. personnel exposed to crude oil combustion products. Combustions products were predicted from the known composition of Kuwaiti crude oil. Monitoring sites were established in Saudi Arabia and Kuwait; about 5,000 environmental samples were studied. Data collected were used to develop health risk assessments for the geographic areas sampled. This initial approach to assessing risk had to be greatly expanded when Congress passed Public Law 102-190, requiring development of means to calculate environmental exposures for individual U.S. service members. To estimate daily exposure levels for the entire area over 10 months for all U.S. troops, air dispersion modeling was used in conjunction with satellite imagery and geographic information system technology. This methodology made it possible to separate the risk caused by oil fire smoke from the total risk from all sources for each service member. The U.S. military responses to health concerns related to the oil well fires and to Public Law 102-190 were reviewed. Consideration was given to changes in technology, practices, and policies over the last two decades that might impact a similar contemporary response. C1 [Heller, Jack M.] USA, Environm Hyg Agcy, Aberdeen Proving Ground, MD 21010 USA. [Heller, Jack M.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Heller, JM (reprint author), 1207 Starmount Lane, Bel Air, MD 21015 USA. NR 15 TC 3 Z9 3 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP 46 EP 51 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100013 PM 21916330 ER PT J AU Martin, LTNJ Richards, CPTEE Kirkpatrick, JS AF Martin, L. T. Nicholas J. Richards, C. P. T. Erin E. Kirkpatrick, Jeffrey S. TI Exposure Science in US Military Operations: A Review SO MILITARY MEDICINE LA English DT Review ID KUWAIT AB Since 1991, the U.S. Department of Defense has conducted deployment occupational and environmental health surveillance activities in the geographic combatant commands for major conflicts, military exercises, and humanitarian and peace-building missions. The DoD has made significant improvements in documenting and assessing deployment environmental hazards and threats since 1991, illustrated by accomplishments in Bosnia. Kosovo, and Operations Noble Eagle (following the September 11, 2001 terrorist attacks); Enduring Freedom-Afghanistan; and Iraqi Freedom (2003-2010). Sampling is now recommended as part of the DoD Exposure Assessment Method, a dynamic process that is performed during all phases of military operations: I-Predeployment, II-Mobilization, III-Conflict, and IV-Postdeployment. From 2001 to 2009, deployed personnel collected over 24,500 air, water, soil, and bulk samples during operations. These efforts have lead to the creation of an environmental health surveillance database that has been used to investigate public health issues. However, gaps exist, especially in the assessment of individual exposures during deployment. C1 [Martin, L. T. Nicholas J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Kirkpatrick, Jeffrey S.] USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA. [Richards, C. P. T. Erin E.] 421st Multifunct Med Battal, APO, AE 09096 USA. RP Martin, LTNJ (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 34 TC 0 Z9 0 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP 77 EP 83 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100018 ER PT J AU Baird, C AF Baird, Coleen TI The Basis for and Uses of Environmental Sampling to Assess Health Risk in Deployed Settings SO MILITARY MEDICINE LA English DT Article ID EXPOSURE; VETERANS AB The ultimate goals of environmental sampling are the protection of health, or barring that, the assessment of health impact to exposed populations. However, environmental samples collected for undefined or poorly defined reasons and that are not part of a feasible strategy of hazard identification, intervention, and follow-up will likely be of limited value. Military commanders and their advisors must be aware of the need to quickly identify potential hazards and to respond appropriately with a comprehensive plan that may include sampling. Before samples are collected, the following must be adequately addressed: (1) the reason for sampling, (2) the parameters to be measured, (3) the possible range of results that might be obtained, and (4) the actions that will be taken in response to various results. Additionally, communication of the risks to commanders and the potentially exposed population is important, particularly if the results are inconclusive. C1 USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Baird, C (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 22 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP 84 EP 90 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100019 PM 21916336 ER PT J AU Lesho, E AF Lesho, Emil TI Prospective Data, Experience, and Lessons Learned at a Surgically Augmented Brigade Medical Company (Level II plus ) During the 2007 Iraq Surge SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 12th Annual Force Health Protection Conference CY 2009 CL Albuquerque, NM ID GULF-WAR; OPERATIONS; FREEDOM; AFGHANISTAN; SUPPORT; TEAM; US; DISEASE; UNIT AB Objective: Provide data and experience at a surgically augmented brigade medical support company during the Iraq surge for future deployments. Methods: Data were prospectively aggregated. Results: Eight thousand and eighty-three patients consisting of 52% coalition military, 19% U.S. military, and 29% U.S. or local civilians were evaluated. Ninety-four percent had disease nonbattle injuries and 4% had battle injuries. Ninety-five percent returned to duty, 2.5% admitted, 2% evacuated, and <1% died of wounds. Total occupied bed days were 416. Predominate trauma and surgical conditions included burns, explosive injury, extremity trauma, and predominate medical conditions included infections, musculoskeletal injuries, and mental health issues. One hundred and fifty-eight air evacuations were required (80% trauma and 20% medical). Conclusion: Challenges included lack of mental health providers, cardiac and chronic medications, and exercise electrocardiogram capability. Without physical therapists, experienced nurses, and ancillary medical care, approximately 1500 more air evacuations would have been required, and return-to-duty would have been significantly delayed for approximately 300 patients. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 21 TC 1 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 BP 763 EP 768 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 792XO UT WOS:000292783900006 PM 22128717 ER PT J AU Marshall, D Walizer, E Vernalis, M AF Marshall, Debra Walizer, Elaine Vernalis, Marina TI The Effect of a One-Year Lifestyle Intervention Program on Carotid Intima Media Thickness SO MILITARY MEDICINE LA English DT Article ID CORONARY-ARTERY-DISEASE; TYPE-2 DIABETES-MELLITUS; HEART-DISEASE; ATHEROSCLEROSIS PROGRESSION; MYOCARDIAL-INFARCTION; REDUCING CHOLESTEROL; RANDOMIZED-TRIAL; RISK-FACTORS; PREVENTION; MEN AB This study assesses the impact of a year long lifestyle intervention program on carotid intima media thickness (CIMT) in 60 subjects, at-risk for or with coronary artery disease. We calculated mean CIMT at baseline (0.731 +/- 0.151 mm) and I year (0.720 +/- 0.129 mm), overall CIMT change and the relationship of CIMT change to the number (0-5) of achieved Heart Health Index (HHI) measures (body mass index <25 kg/m(2), exercise >= 150 min/wk, blood pressure < 140/90 mm Hg, LDL-Cholesterol < 100 mg/dL, fiber intake > 25 g/d). CIMT was unchanged (-0.011 +/- 0.118 mm; p = 0.48); however, there was a trend toward CIMT decrease (-0.025 +/- 0.120 mm vs. +0.033 +/- 0.102 mm; p = 0.10) between subjects with HHI Score >= 3 (a = 45) compared to those with an HHI Score <3 (n = 15) at 1 year. These findings suggest atherosclerosis progression can be blunted with a lifestyle intervention that fully leverages nonpharmacologic approaches to cardiovascular risk reduction. C1 [Marshall, Debra] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46825 USA. [Walizer, Elaine; Vernalis, Marina] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20307 USA. RP Marshall, D (reprint author), Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46825 USA. FU U.S. Army Medical Research & Materiel Command; Telemedicine & Advanced Technology Research Center, at Fort Detrick, Maryland [W81XWH-05-2-0075] FX This research and project was conducted by the Henry M. Jackson Foundation and is made possible by a cooperative agreement that was awarded and administered by the U.S. Army Medical Research & Materiel Command and the Telemedicine & Advanced Technology Research Center, at Fort Detrick, Maryland, under Contract Number W81XWH-05-2-0075. NR 39 TC 0 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 BP 798 EP 804 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XO UT WOS:000292783900011 PM 22128722 ER PT J AU Kragh, JF O'Neill, ML Walters, TJ Jones, JA Baer, DG Gershman, LK Wade, CE Holcomb, JB AF Kragh, John F., Jr. O'Neill, Michelle L. Walters, Thomas J. Jones, John A. Baer, David G. Gershman, Leigh K. Wade, Charles E. Holcomb, John B. TI Minor Morbidity With Emergency Tourniquet Use to Stop Bleeding in Severe Limb Trauma: Research, History, and Reconciling Advocates and Abolitionists SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 51st Annual Meeting of the Society-of-Military-Orthopedic-Surgeons (SOMOS) CY DEC 08, 2009 CL Honolulu, HI SP Soc Mil Orthoped Surg ID COMBAT CASUALTY CARE; HEMORRHAGE CONTROL; PNEUMATIC TOURNIQUET; EXPERIMENTAL SHOCK; CRUSH INJURY; BATTLEFIELD; EXTREMITY; DEATH; PRESSURES AB Background: In prior reports of active data collection, we demonstrated that early use of emergency tourniquets is associated with improved survival and only minor morbidity. To check these new and important results, we continued critical evaluation of tourniquet use for 6 more months in the current study to see if results were consistent. Methods: We continued a prospective survey of casualties and their records at a combat support hospital in Baghdad who had tourniquets used at a combat hospital in Baghdad (NCT00517166 at ClinicalTrials.gov). Results: After comparable methods were verified for both the first and current studies, we report the results of 499 patients who had 862 tourniquets applied on 651 limbs. The clinical results were consistent. No limbs were lost from tourniquet use. Conclusion: We found that morbidity was minor in light of major survival benefits consistent with prior reports. C1 [Kragh, John F., Jr.; Walters, Thomas J.; Jones, John A.; Baer, David G.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [O'Neill, Michelle L.] Tripler Army Med Ctr, Dept Nursing, Tripler, HI 96859 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611,Rm 282-4, Ft Sam Houston, TX 78234 USA. NR 68 TC 28 Z9 29 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 BP 817 EP 823 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XO UT WOS:000292783900014 PM 22128725 ER PT J AU Harcke, HT Crawley, G Mabry, R Mazuchowski, E AF Harcke, H. Theodore Crawley, Geoffrey Mabry, Robert Mazuchowski, Edward TI Placement of Tibial Intraosseous Infusion Devices SO MILITARY MEDICINE LA English DT Article ID ACCESS AB Post-mortem preautopsy multidetector computed tomography was used to assess the placement of tibial intraosseous infusion needles in 52 cases of battlefield trauma deaths for which medical intervention included the use of the technique. In 58 (95%) of 61 needles, the tip was positioned in medullary bone. All 3 (5%) unsuccessful placements were in the left leg, and the needle was not directed perpendicular to the medial tibial cortex as recommended. Considering the nature of military trauma and the environmental conditions under which care is rendered, military medical personnel appear to be highly successful in the placement of tibial intraosseous infusion needles. C1 [Harcke, H. Theodore] Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. [Harcke, H. Theodore] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. [Mabry, Robert] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Crawley, Geoffrey] Dover AFB, Med Grp 436, Dover, DE 19902 USA. [Mazuchowski, Edward] Armed Forces Inst Pathol, Off Armed Forces Med Examiner, Rockville, MD 20850 USA. RP Harcke, HT (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, 6825 16th St NW, Washington, DC 20306 USA. NR 13 TC 3 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 BP 824 EP 827 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 792XO UT WOS:000292783900015 PM 22128726 ER PT J AU Shogan, PJ Folio, L AF Shogan, Paul J. Folio, Les TI Situs Inversus Totalis SO MILITARY MEDICINE LA English DT Article ID CONGENITAL HEART-DISEASE; VISCEROATRIAL SITUS; ADULTS AB We present a case of situs inversus totalis. A 22-month-old infant presented with cyanosis, double-inlet left ventricle, severe pulmonary stenosis, and concern for underlying visceroatrial abnormalities. Chest (Fig. 1) and abdominal (Fig. 2) radiographs were obtained. Abdominal sonography was performed to clarify the presence of splenic tissue and further define the relationships of the inferior vena cava and abdominal aorta (Figs. 3-7). This case demonstrates typical radiographic and sonographic findings of situs inversus totalis and shows the utility of sonography. C1 [Shogan, Paul J.] Walter Reed Army Med Ctr, Dept Radiol, Natl Capital Consortium, Washington, DC 20307 USA. [Shogan, Paul J.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Folio, Les] NIH, Bethesda, MD 20892 USA. RP Shogan, PJ (reprint author), Walter Reed Army Med Ctr, Dept Radiol, Natl Capital Consortium, Washington, DC 20307 USA. NR 7 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 BP 840 EP 843 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 792XO UT WOS:000292783900018 PM 22128729 ER PT J AU Petkar, A Rao, L Elizondo, DR Cutler, J Taillon, D Magone, MT AF Petkar, Animesh Rao, Luigi Elizondo, Daniel R. Cutler, Jeffrey Taillon, Donald Magone, M. Teresa TI Allergic Fungal Sinusitis With Massive Intracranial Extension Presenting With Tearing SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID ORBITAL INVOLVEMENT; MANAGEMENT AB A 24-year-old male presented with tearing, and subsequent workup and imaging showed a mass with fluid involving the nasopharynx, the paranasal sinuses, and the posterior dehiscence of the left frontal sinus intracranially compressing the frontal lobe significantly. Microscopic examination confirmed the diagnosis of allergic fungal sinusitis. Endoscopic drainage and sinostomy was performed by the otolaryngology (ear-nose-throat) service. The patient was followed 9 months postoperatively and did well with resolution of the epiphora. Although epiphora alone is an unusual presentation of allergic fungal sinusitis, ophthalmologists need to be aware of this entity, as it may invade the orbit through the sinus cavities or compress on the nasolacrimal duct before it causes other mass-related symptoms. Radiology and the characteristic histopathologic findings are the most useful in establishing the correct diagnosis. C1 [Petkar, Animesh; Elizondo, Daniel R.; Magone, M. Teresa] Natl Naval Med Ctr, Dept Ophthalmol, Bethesda, MD 20889 USA. [Petkar, Animesh] Howard Univ Hosp, Dept Ophthalmol, Washington, DC USA. [Rao, Luigi; Taillon, Donald] Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, Washington, DC 20307 USA. [Cutler, Jeffrey] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Magone, MT (reprint author), Natl Naval Med Ctr, Dept Ophthalmol, 8901 Wisconsin Ave,Bldg 8, Bethesda, MD 20889 USA. EM teresa.magone@med.navy.mil NR 8 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHAL PLAST RECONS JI Ophthalmic Plast. Reconstr. Surg. PD JUL-AUG PY 2011 VL 27 IS 4 BP E98 EP E100 DI 10.1097/IOP.0b013e3181f29c9d PG 3 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 791BB UT WOS:000292633700009 PM 21750424 ER PT J AU Marple, R AF Marple, Ronald TI Comment on the Companion Articles "Finding Faults in the Charleston Area, South Carolina: 1. Seismological Data" by I. Dura-Gomez and P. Talwani and "Finding Faults in the Charleston Area, South Carolina: 2. Complementary Data" by P. Talwani and I. Dura-Gomez SO SEISMOLOGICAL RESEARCH LETTERS LA English DT Editorial Material ID SAN-ANDREAS FAULT; CRUZ MOUNTAINS; COASTAL-PLAIN; BEND; CALIFORNIA; EARTHQUAKE; MORPHOLOGY; RUPTURE; SYSTEM C1 [Marple, Ronald] USA, Washington, DC USA. RP Marple, R (reprint author), 4883 Battery Lane,Apt 1, Bethesda, MD 20814 USA. EM ronald.t.marple@us.army.mil NR 33 TC 1 Z9 1 U1 1 U2 2 PU SEISMOLOGICAL SOC AMER PI EL CERRITO PA PLAZA PROFESSIONAL BLDG, SUITE 201, EL CERRITO, CA 94530 USA SN 0895-0695 J9 SEISMOL RES LETT JI Seismol. Res. Lett. PD JUL-AUG PY 2011 VL 82 IS 4 BP 599 EP 605 DI 10.1785/gssrl.82.4.599 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 790WY UT WOS:000292622700013 ER PT J AU Schwenk, RJ Richie, TL AF Schwenk, Robert J. Richie, Thomas L. TI Protective immunity to pre-erythrocytic stage malaria SO TRENDS IN PARASITOLOGY LA English DT Review ID T-CELL RESPONSES; PLASMODIUM-FALCIPARUM SPOROZOITES; YELLOW-FEVER VACCINE; LIVER STAGES; CIRCUMSPOROZOITE PROTEIN; IRRADIATED SPOROZOITES; IN-VIVO; PROTRACTED PROTECTION; MEDIATED PROTECTION; STERILE PROTECTION AB The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known about protective immunity against pre-erythrocytic stage malaria by considering the humoral and T cell-mediated immune responses that are induced by attenuated sporozoites and by the RTS,S vaccine. On the basis of these observations a set of research priorities are defined that are crucial for the development of a vaccine capable of inducing long-lasting and high-grade protection against malaria. C1 [Schwenk, Robert J.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Richie, Thomas L.] USN, Med Res Ctr, Infect Dis Directorate, Silver Spring, MD 20910 USA. EM robert.schwenk@amedd.army.mil OI Richie, Thomas/0000-0002-2946-5456 NR 78 TC 19 Z9 19 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD JUL PY 2011 VL 27 IS 7 BP 306 EP 314 DI 10.1016/j.pt.2011.02.002 PG 9 WC Parasitology SC Parasitology GA 791PD UT WOS:000292676200006 PM 21435951 ER PT J AU Kim, SE Bahta, M Lountos, GT Ulrich, RG Burke, TR Waugh, DS AF Kim, Sung-Eun Bahta, Medhanit Lountos, George T. Ulrich, Robert G. Burke, Terrence R., Jr. Waugh, David S. TI Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH SO ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY LA English DT Article ID PROMISCUOUS INHIBITORS; BIDENTATE INHIBITORS; CRYSTAL-STRUCTURES; 1B INHIBITORS; DESIGN; PHOSPHOTYROSINE; MECHANISM; LIBRARY; MODEL; CRYSTALLOGRAPHY AB Isothiazolidinone (IZD) heterocycles can act as effective components of protein tyrosine phosphatase (PTP) inhibitors by simultaneously replicating the binding interactions of both a phosphoryl group and a highly conserved water molecule, as exemplified by the structures of several PTP1B-inhibitor complexes. In the first unambiguous demonstration of IZD interactions with a PTP other than PTP1B, it is shown by X-ray crystallography that the IZD motif binds within the catalytic site of the Yersinia pestis PTP YopH by similarly displacing a highly conserved water molecule. It is also shown that IZD-based bidentate ligands can inhibit YopH in a nonpromiscuous fashion at low micromolar concentrations. Hence, the IZD moiety may represent a useful starting point for the development of YopH inhibitors. C1 [Kim, Sung-Eun; Bahta, Medhanit; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Frederick, MD 21702 USA. [Lountos, George T.; Waugh, David S.] NCI, Ctr Macromol Crystallog, Frederick, MD 21702 USA. [Ulrich, Robert G.] USA, Lab Mol Immunol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Burke, TR (reprint author), NCI, Biol Chem Lab, POB B, Frederick, MD 21702 USA. EM tburke@helix.nih.gov; waughd@mail.nih.gov RI Burke, Terrence/N-2601-2014; Lountos, George/B-3983-2015 FU NIH, Center for Cancer Research, NCI-Frederick; National Cancer Institute, National Institutes of Health; Joint Science and Technology Office of the Department of Defense FX Appreciation is expressed to Afroz Sultana (LMI) for technical support and to Joseph Tropea and Scott Cherry (MCL) for purification of YopH. Electrospray mass-spectrometry experiments were conducted on the LC/ESMS instrument maintained by the Biophysics Resource in the Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute at Frederick. This work was supported in part by the Intramural Research Program of the NIH, Center for Cancer Research, NCI-Frederick and the National Cancer Institute, National Institutes of Health and the Joint Science and Technology Office of the Department of Defense. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. NR 49 TC 13 Z9 13 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0907-4449 J9 ACTA CRYSTALLOGR D JI Acta Crystallogr. Sect. D-Biol. Crystallogr. PD JUL PY 2011 VL 67 BP 639 EP 645 DI 10.1107/S0907444911018610 PN 7 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography SC Biochemistry & Molecular Biology; Biophysics; Crystallography GA 788RD UT WOS:000292461200006 PM 21697602 ER PT J AU Mines, MJ Bower, KS Lappan, CM Mazzoli, RA Poropatich, RK AF Mines, Michael J. Bower, Kraig S. Lappan, Charles M. Mazzoli, Robert A. Poropatich, Ronald K. TI The United States Army Ocular Teleconsultation program 2004 through 2009 SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID LOW-COST TELEMEDICINE; MESSAGE-ROUTING SYSTEM; EXPERIENCE; OPHTHALMOLOGY AB PURPOSE: To describe the United States Army Ocular Teleconsultation program and all consultations received from its inception in July 2004 through December 2009. DESIGN: Retrospective, noncomparative, consecutive case series. METHODS: All 301 consecutive ocular teleconsultations received were reviewed. The main outcome measures were differential diagnosis, evacuation recommendations, and origination of consultation. Secondary measures included patient demographics, reason for consultation, and inclusion of clinical images. RESULTS: The average response time was 5 hours and 41 minutes. Most consultations originated from Iraq (58.8%) and Afghanistan (18.6%). Patient care-related requests accounted for 94.7% of consultations; nonphysicians submitted 26.3% of consultations. Most patients (220/285; 77.2%) were United States military personnel; the remainder included local nationals and coalition forces. Children accounted for 23 consultations (8.1%). Anterior segment disease represented the largest grouping of cases (129/285; 45.3%); oculoplastic problems represented nearly one quarter (68/285; 23.9%). Evacuation was recommended in 123 (43.2%) of 285 cases and in 21 (58.3%) of 36 cases associated with trauma. Photographs were included in 38.2%, and use was highest for pediatric and strabismus (83.3%) and oculoplastic (67.6%) consultations. Consultants facilitated evacuation in 87 (70.7%) of 123 consultations where evacuation was recommended and avoided unnecessary evacuations in 28 (17.3%) of 162 consultations. CONCLUSIONS: This teleconsultation program has brought valuable tertiary level support to deployed providers, thereby helping to facilitate appropriate and timely referrals, and in some cases avoiding unnecessary evacuation. Advances in remote diagnostic and imaging technology could further enhance consultant support to distant providers and their patients. (Am J Ophthalmol 2011;152:126-132. Published by Elsevier Inc.) C1 [Mines, Michael J.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Bower, Kraig S.] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA. [Mines, Michael J.; Bower, Kraig S.; Mazzoli, Robert A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Lappan, Charles M.] So Reg Med Command, Ft Sam Houston, TX USA. [Mazzoli, Robert A.] Madigan Army Med Ctr, Ophthalmol Serv, Tacoma, WA 98431 USA. [Poropatich, Ronald K.] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Mines, MJ (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave NW,Room 1F-18, Washington, DC 20307 USA. EM Michael.mines@amedd.army.mil NR 23 TC 9 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD JUL PY 2011 VL 152 IS 1 BP 126 EP 132 DI 10.1016/j.ajo.2011.01.028 PG 7 WC Ophthalmology SC Ophthalmology GA 789CI UT WOS:000292490500021 PM 21570049 ER PT J AU Singh, JP Almirall, JR Sabsabi, M Miziolek, AW AF Singh, Jagdish P. Almirall, Jose R. Sabsabi, Mohamad Miziolek, Andrzej W. TI Laser-induced breakdown spectroscopy (LIBS) SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Editorial Material C1 [Almirall, Jose R.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [Almirall, Jose R.] Florida Int Univ, Int Forens Res Inst, Miami, FL 33199 USA. [Singh, Jagdish P.] Mississippi State Univ, Inst Clean Energy Technol, Starkville, MS 39759 USA. [Sabsabi, Mohamad] Natl Res Council Canada, Inst Ind Mat, Boucherville, PQ J4B 6Y4, Canada. [Miziolek, Andrzej W.] USA, Res Lab, RDRL WML A, Aberdeen Proving Ground, MD 21005 USA. RP Almirall, JR (reprint author), Florida Int Univ, Dept Chem & Biochem, 11200 SW 8th St, Miami, FL 33199 USA. EM Almirall@fiu.edu RI Almirall, Jose/D-1280-2010 OI Almirall, Jose/0000-0002-5257-7499 NR 0 TC 7 Z9 7 U1 1 U2 18 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUL PY 2011 VL 400 IS 10 BP 3191 EP 3192 DI 10.1007/s00216-011-5073-5 PG 2 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 789IE UT WOS:000292508200002 PM 21559754 ER PT J AU Gottfried, JL AF Gottfried, Jennifer L. TI Discrimination of biological and chemical threat simulants in residue mixtures on multiple substrates SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE LIBS; PLS-DA; Biological warfare agents; Chemical warfare agents; Residue detection ID INDUCED BREAKDOWN SPECTROSCOPY; WARFARE AGENT SIMULANTS; LASER-ABLATION; IDENTIFICATION; CLASSIFICATION; BACTERIA; STRATEGIES; EMISSION; EXAMPLE; SURFACE AB The potential of laser-induced breakdown spectroscopy (LIBS) to discriminate biological and chemical threat simulant residues prepared on multiple substrates and in the presence of interferents has been explored. The simulant samples tested include Bacillus atrophaeus spores, Escherichia coli, MS-2 bacteriophage, alpha-hemolysin from Staphylococcus aureus, 2-chloroethyl ethyl sulfide, and dimethyl methylphosphonate. The residue samples were prepared on polycarbonate, stainless steel and aluminum foil substrates by Battelle Eastern Science and Technology Center. LIBS spectra were collected by Battelle on a portable LIBS instrument developed by A3 Technologies. This paper presents the chemometric analysis of the LIBS spectra using partial least-squares discriminant analysis (PLS-DA). The performance of PLS-DA models developed based on the full LIBS spectra, and selected emission intensities and ratios have been compared. The full-spectra models generally provided better classification results based on the inclusion of substrate emission features; however, the intensity/ratio models were able to correctly identify more types of simulant residues in the presence of interferents. The fusion of the two types of PLS-DA models resulted in a significant improvement in classification performance for models built using multiple substrates. In addition to identifying the major components of residue mixtures, minor components such as growth media and solvents can be identified with an appropriately designed PLS-DA model. C1 USA, Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. EM jennifer.gottfried@us.army.mil RI Gottfried, Jennifer/G-6333-2010 FU US Army Research Laboratory FX Sample preparation and data collection were performed by Battelle technicians Dana Short, Tyler Goralski, and Stephanie McCaslin (study director, Kimberly Weber) with funding from the US Army Research Laboratory. LIBS spectra were collected by Battelle at A3 Technologies with the assistance of Diane Wong. The author also wishes to thank Richard Rossman (Battelle) for providing the spectral data and experimental details and Frank De Lucia, Jr., for a critical reading of the manuscript. NR 44 TC 27 Z9 28 U1 4 U2 25 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUL PY 2011 VL 400 IS 10 BP 3289 EP 3301 DI 10.1007/s00216-011-4746-4 PG 13 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 789IE UT WOS:000292508200012 PM 21331489 ER PT J AU Harmon, RS Shughrue, KM Remus, JJ Wise, MA East, LJ Hark, RR AF Harmon, Russell S. Shughrue, Katrina M. Remus, Jeremiah J. Wise, Michael A. East, Lucille J. Hark, Richard R. TI Can the provenance of the conflict minerals columbite and tantalite be ascertained by laser-induced breakdown spectroscopy? SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Laser-induced breakdown spectroscopy; LIBS; Conflict minerals; Columbite-tantalite; Coltan; PLSDA ID GRANITIC PEGMATITES; CHEMISTRY; PROVINCE AB Conflict minerals is a term applied to ores mined in conditions of armed conflict and human rights abuse. Niobium and tantalum are two rare metals whose primary natural occurrence is in the complex oxide minerals columbite and tantalite, the ore of which is commonly referred to as coltan. The illicit export of coltan ore from the Democratic Republic of the Congo is thought to be responsible for financing the ongoing civil conflicts in this region. Determining the chemical composition of an ore is one of the means of ascertaining its provenance. Laser-induced breakdown spectroscopy (LIBS) offers a means of rapidly distinguishing different geographic sources for a mineral because the LIBS plasma emission spectrum provides the complete chemical composition (i.e., "chemical fingerprint") of any material in real time. To test this idea for columbite-tantalite, three sample sets were analyzed. Partial least squares discriminant analysis (PLSDA) allows correct sample-level geographic discrimination at a success rate exceeding 90%. C1 [Shughrue, Katrina M.; Hark, Richard R.] Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA. [Harmon, Russell S.] ARL Army Res Off, Div Environm Sci, Durham, NC 27709 USA. [Remus, Jeremiah J.] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Wise, Michael A.] Smithsonian Inst, Dept Mineral Sci, Washington, DC 20013 USA. [East, Lucille J.] Appl Spectra Inc, Fremont, CA 94538 USA. RP Hark, RR (reprint author), Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA. EM hark@juniata.edu FU Army Research Laboratory; II-VI Foundation FX This research was supported by Army Research Laboratory Fellow funding to RSH and financial support to KMS from the II-VI Foundation and was facilitated by technical support from Applied Spectra, Inc. NR 21 TC 22 Z9 22 U1 3 U2 35 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUL PY 2011 VL 400 IS 10 BP 3377 EP 3382 DI 10.1007/s00216-011-5015-2 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 789IE UT WOS:000292508200020 PM 21537914 ER PT J AU Canter, TH Burken, JG Wang, JM Fitch, MW Kinnevan, KJ Wedge, K Tucker, RE AF Canter, Tim H. Burken, Joel G. Wang, Jianmin Fitch, Mark W. Kinnevan, Kurt J. Wedge, Keith Tucker, Robert E. TI Environment of Warfare SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article C1 [Canter, Tim H.; Burken, Joel G.; Wang, Jianmin; Fitch, Mark W.] Missouri Univ Sci & Technol, Rolla, MO 65409 USA. [Kinnevan, Kurt J.] US Army Corps Engn, Construct Engn Res Lab, Champaign, IL 61826 USA. [Wedge, Keith] Advancia Corp, St Robert, MO 65584 USA. [Tucker, Robert E.] USA, Joint Program Integrat Off, Theater Environm Programs, APO, AE 09356 USA. RP Burken, JG (reprint author), Missouri Univ Sci & Technol, 224 Butler Carlton Hall,Missouri S&T, Rolla, MO 65409 USA. EM burken@mst.edu FU Leonard Wood Institute [LWI 281173] FX This work developed from research funding from the Leonard Wood Institute, project LWI 281173. This article does not represent the views or opinions of Leonard Wood Institute. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD JUL PY 2011 VL 137 IS 7 BP 525 EP 530 DI 10.1061/(ASCE)EE.1943-7870.0000362 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 789MM UT WOS:000292519600001 ER PT J AU Abraham, D Kuhnle, RA Odgaard, AJ AF Abraham, David Kuhnle, Roger A. Odgaard, A. Jacob TI Validation of Bed-Load Transport Measurements with Time-Sequenced Bathymetric Data SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article DE Bed load; Transport; Bathymetry; Dunes; Rivers ID RIVERS AB Advances in bathymetric data acquisition have made it possible to explore alternative methods for measuring bed-load transport in rivers. The method validated herein consists of measuring rates of bed scour by using time-sequenced bathymetric data. The validation is performed in a laboratory flume by comparing the measured rates of bed scour with direct measurements of bed-load transport. The bed forms in the flume are dunes traveling at nearly constant speed. The shape of the dunes remains nearly constant. No suspended load is present. The ranges for Froude and Rouse numbers are 0.24-0.50 and 4.6-10.4, respectively. The study shows that under the given conditions, bed-load transport determined from time-sequenced bathymetric data is equally accurate to that determined from measurements of bed-form amplitude and speed. Obtaining bed-load transport from time-sequenced bathymetric data is often more expedient than traditional methods. DOI: 10.1061/(ASCE)HY.1943-7900.0000357. (C) 2011 American Society of Civil Engineers. C1 [Abraham, David] USA, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Kuhnle, Roger A.] ARS, Natl Sedimentat Lab, USDA, Oxford, MS 38655 USA. [Odgaard, A. Jacob] Univ Iowa, Maxwell Stanley Hydraul Lab, Iowa City, IA 52242 USA. RP Abraham, D (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM David.D.Abraham@usace.army.mil FU U.S. Army Corps of Engineers Engineer Research and Development Center (USACE-ERDC) in cooperation with the Agricultural Research Service-National Sedimentation Laboratory (ARS-NSL); Iowa Institute of Hydraulic Research (IIHR) at the University of Iowa FX The research and data analysis presented herein were conducted under the sponsorship of the U.S. Army Corps of Engineers Engineer Research and Development Center (USACE-ERDC) in cooperation with the Agricultural Research Service-National Sedimentation Laboratory (ARS-NSL) and the Iowa Institute of Hydraulic Research (IIHR) at the University of Iowa. Permission was granted by the Chief of Engineers to publish this information. NR 23 TC 4 Z9 4 U1 2 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 2011 VL 137 IS 7 BP 723 EP 728 DI 10.1061/(ASCE)HY.1943-7900.0000357 PG 6 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 789LX UT WOS:000292518100002 ER PT J AU Warner, A Opperman, JJ Pietrowsky, R AF Warner, Andrew Opperman, Jeffrey J. Pietrowsky, Robert TI A Call to Enhance the Resiliency of the Nation's Water Management SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Editorial Material ID AMERICAN FRESH-WATER C1 [Warner, Andrew] Nature Conservancy, Global Freshwater Program, University Pk, PA 16802 USA. [Opperman, Jeffrey J.] Nature Conservancy, Global Freshwater Program, Chagrin Falls, OH 44022 USA. [Pietrowsky, Robert] USA, Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. RP Warner, A (reprint author), Nature Conservancy, Global Freshwater Program, 406 Forest Resources Bldg, University Pk, PA 16802 USA. EM awarner@tnc.org; jopperman@tnc.org; robert.a.pietrowsky@usace.army.mil NR 13 TC 5 Z9 5 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD JUL-AUG PY 2011 VL 137 IS 4 BP 305 EP 308 DI 10.1061/(ASCE)WR.1943-5452.0000151 PG 4 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 789LG UT WOS:000292516400001 ER PT J AU Lee, SY Fitzgerald, CJ Hamlet, AF Burges, SJ AF Lee, Se-Yeun Fitzgerald, Carolyn J. Hamlet, Alan F. Burges, Stephen J. TI Daily Time-Step Refinement of Optimized Flood Control Rule Curves for a Global Warming Scenario SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article DE Climatic change; Flood control; Flood rule curve; Reservoir operation; Columbia River; Optimization; Simulation; Hydrologic modeling; Daily time step; Monthly time step ID COLUMBIA RIVER-BASIN; CLIMATE-CHANGE SCENARIOS; WATER-RESOURCES; PACIFIC-NORTHWEST; WASHINGTON-STATE; HYDROLOGY; IMPACTS AB Pacific Northwest temperatures have warmed by 0.8 degrees C since 1920 and are predicted to increase in the 21st century. Streamflow timing shifts associated with climate change would degrade the water resources system performance for climate change scenarios using existing system operation policies for the Columbia River Basin. To mitigate the hydrologic impacts of anticipated climate change on this complex water resource system, optimized flood control operating rule curves were developed at a monthly time step in a previous study and were evaluated with a monthly time-step simulation model. Here, a daily time-step simulation model is used over a smaller portion of the domain to evaluate and refine the optimized flood-control curves derived from monthly time-step analysis. Daily time-step simulations demonstrate that maximum evacuation targets for flood control derived from the monthly analysis were remarkably robust. However, the evacuation schedules for Libby and Duncan Dams from February to April conflicted with Kootenay Lake level requirements specified in the 1938 International Joint Commission Order on Kootenay Lake. We refined the flood rule curves derived from monthly analysis by creating a gradual evacuation schedule, keeping the timing and magnitude of maximum evacuation the same as in the monthly analysis. After these refinements, the performance at monthly timescales reported in our previous study proved robust at daily timescales. Owing to a decrease in July storage deficits, additional benefits such as more revenue from hydropower generation and more July and August outflow for fish augmentation were observed when the optimized flood-control curves were used for a climate-change scenario. DOI: 10.1061/(ASCE)WR.1943-5452.0000125. (C) 2011 American Society of Civil Engineers. C1 [Lee, Se-Yeun; Hamlet, Alan F.; Burges, Stephen J.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Fitzgerald, Carolyn J.] USA, Corps Engineers, Seattle, WA 98134 USA. [Hamlet, Alan F.] Univ Washington, CSES Climate Impacts Grp, Seattle, WA 98195 USA. RP Lee, SY (reprint author), Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. EM leesy@u.washington.edu NR 25 TC 5 Z9 6 U1 0 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD JUL-AUG PY 2011 VL 137 IS 4 BP 309 EP 317 DI 10.1061/(ASCE)WR.1943-5452.0000125 PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 789LG UT WOS:000292516400002 ER PT J AU Houston, JR AF Houston, James R. TI In Memoriam: Nicholas C. Kraus SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Biographical-Item C1 Engn Res & Dev Ctr, Vicksburg, MS USA. RP Houston, JR (reprint author), Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM james.r.houston@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 2011 VL 137 IS 4 BP 161 EP 162 DI 10.1061/(ASCE)WW.1943-5460.0000091 PG 2 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 789LV UT WOS:000292517900001 ER PT J AU Douglas, NA Wall, WA Xiang, QY Hoffmann, WA Wentworth, TR Gray, JB Hohmann, MG AF Douglas, Norman A. Wall, Wade A. Xiang, Qiu-Yun (Jenny) Hoffmann, William A. Wentworth, Thomas R. Gray, Janet B. Hohmann, Matthew G. TI Recent vicariance and the origin of the rare, edaphically specialized Sandhills lily, Lilium pyrophilum (Liliaceae): evidence from phylogenetic and coalescent analyses SO MOLECULAR ECOLOGY LA English DT Article DE coalescence; divergence; edaphic; Lilium; Pleistocene; rarity ID WIDESPREAD PLANT CONGENERS; GENE FLOW; MOLECULAR PHYLOGENY; POPULATION DIFFERENTIATION; COMPARATIVE PHYLOGEOGRAPHY; HAPLOTYPE RECONSTRUCTION; STATISTICAL-METHOD; DNA POLYMORPHISM; UNITED-STATES; DIVERGENCE AB Establishing the phylogenetic and demographic history of rare plants improves our understanding of mechanisms that have led to their origin and can lead to valuable insights that inform conservation decisions. The Atlantic coastal plain of eastern North America harbours many rare and endemic species, yet their evolution is poorly understood. We investigate the rare Sandhills lily (Lilium pyrophilum), which is endemic to seepage slopes in a restricted area of the Atlantic coastal plain of eastern North America. Using phylogenetic evidence from chloroplast, nuclear internal transcribed spacer and two low-copy nuclear genes, we establish a close relationship between L. pyrophilum and the widespread Turk's cap lily, L. superbum. Isolation-with-migration and coalescent simulation analyses suggest that (i) the divergence between these two species falls in the late Pleistocene or Holocene and almost certainly post-dates the establishment of the edaphic conditions to which L. pyrophilum is presently restricted, (ii) vicariance is responsible for the present range disjunction between the two species, and that subsequent gene flow has been asymmetrical and (iii) L. pyrophilum harbours substantial genetic diversity in spite of its present rarity. This system provides an example of the role of edaphic specialization and climate change in promoting diversification in the Atlantic coastal plain. C1 [Douglas, Norman A.; Wall, Wade A.; Xiang, Qiu-Yun (Jenny); Hoffmann, William A.; Wentworth, Thomas R.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL USA. [Gray, Janet B.] USA, Directorate Publ Works, Endangered Species Branch, Ft Bragg, NC 28310 USA. RP Douglas, NA (reprint author), N Carolina State Univ, Dept Plant Biol, POB 7612, Raleigh, NC 27695 USA. EM norman_douglas@ncsu.edu RI Hoffmann, William/E-8894-2010 OI Hoffmann, William/0000-0002-1926-823X FU Construction Engineering Research Laboratory (US Army Corps of Engineers) [W9132T-07-2-0019] FX We thank Fort Bragg Military Reservation and the Endangered Species Branch for logistic support and the Construction Engineering Research Laboratory (US Army Corps of Engineers Agreement #W9132T-07-2-0019) for funding. We also thank Xiang Liu, David Thomas, Patrick Zhou, Esther Ichugo, Matt Cleary and Jacob Hilton for assistance with laboratory work and Marshall Wilson, Tom Phillips, Mac Alford, Rob Naczi, Gary Shurette, Viola Walker, Emil Devito, Heather Sullivan, Paul Manos, John Pogacnik, James Smith, Wayne Longbottom, Misty Buchanan and others for assistance locating Lilium populations. NR 89 TC 11 Z9 11 U1 5 U2 33 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 J9 MOL ECOL JI Mol. Ecol. PD JUL PY 2011 VL 20 IS 14 BP 2901 EP 2915 DI 10.1111/j.1365-294X.2011.05151.x PG 15 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 788LF UT WOS:000292445700005 PM 21672067 ER PT J AU Stromdahl, EY Jiang, J Vince, M Richards, AL AF Stromdahl, Ellen Y. Jiang, Ju Vince, Mary Richards, Allen L. TI Infrequency of Rickettsia rickettsii in Dermacentor variabilis Removed from Humans, with Comments on the Role of Other Human-Biting Ticks Associated with Spotted Fever Group Rickettsiae in the United States SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Amblyomma; Dermacentor; Rhiphicephalus; Rickettsia; Tick(s); Vector-borne; Zoonosis ID AMBLYOMMA-AMERICANUM ACARI; BROWN DOG TICK; RHIPICEPHALUS-SANGUINEUS ACARI; NORTH-CAROLINA; HUMAN PARASITISM; IXODIDAE; VECTOR; PREVALENCE; ANDERSONI; INFECTION AB From 1997 to 2009, the Tick-Borne Disease Laboratory of the U. S. Army Public Health Command (USAPHC) (formerly the U. S. Army Center for Health Promotion and Preventive Medicine) screened 5286 Dermacentor variabilis ticks removed from Department of Defense (DOD) personnel, their dependents, and DOD civilian personnel for spotted fever group rickettsiae using polymerase chain reaction and restriction fragment length polymorphism analysis. Rickettsia montanensis (171/5286 = 3.2%) and Rickettsia amblyommii (7/5286 = 0.1%) were detected in a small number of samples, but no ticks were found positive for Rickettsia rickettsii, the agent of Rocky Mountain spotted fever (RMSF) until May 2009, when it was detected in one D. variabilis male removed from a child in Maryland. This result was confirmed by nucleotide sequence analysis of the rickettsial isolate and of the positive control used in the polymerase chain reaction, which was different from the isolate. Lethal effects of rickettsiostatic proteins of D. variabilis on R. rickettsii and lethal effects of R. rickettsii infection on tick hosts may account for this extremely low prevalence. Recent reports of R. rickettsii in species Rhipicephalus sanguineus and Amblyomma americanum ticks suggest their involvement in transmission of RMSF, and other pathogenic rickettsiae have been detected in Amblyomma maculatum. The areas of the U. S. endemic for RMSF are also those where D. variabilis exist in sympatry with populations of A. americanum and A. maculatum. Interactions among the sympatric species of ticks may be involved in the development of a focus of RMSF transmission. On the other hand, the overlap of foci of RMSF cases and areas of A. americanum and A. maculatum populations might indicate the misdiagnosis as RMSF of diseases actually caused by other rickettsiae vectored by these ticks. Further studies on tick vectors are needed to elucidate the etiology of RMSF. C1 [Stromdahl, Ellen Y.; Vince, Mary] USA, Entomol Sci Program, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Jiang, Ju; Richards, Allen L.] USN, Viral & Rickettsial Dis Dept, Med Res Ctr, Silver Spring, MD USA. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Prevent Med & Boimetr Dept, Bethesda, MD 20814 USA. RP Stromdahl, EY (reprint author), USA, Entomol Sci Program, Publ Hlth Command Provis, 5158 Blackhawk Rd,BLDG E-5800, Aberdeen Proving Ground, MD 21010 USA. EM ellen.stromdahl@us.army.mil RI Valle, Ruben/A-7512-2013 NR 50 TC 36 Z9 37 U1 1 U2 27 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUL PY 2011 VL 11 IS 7 BP 969 EP 977 DI 10.1089/vbz.2010.0099 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 789TV UT WOS:000292540100028 PM 21142953 ER PT J AU Borgman, MA Spinella, PC Holcomb, JB Blackbourne, LH Wade, CE Lefering, R Bouillon, B Maegele, M AF Borgman, M. A. Spinella, P. C. Holcomb, J. B. Blackbourne, L. H. Wade, C. E. Lefering, R. Bouillon, B. Maegele, M. TI The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score SO VOX SANGUINIS LA English DT Article DE blood component transfusion; resuscitation; wounds and injuries ID FRESH-FROZEN PLASMA; LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; ACUTE LUNG INJURY; RED-BLOOD-CELLS; 753 CONSECUTIVE DEATHS; LAST 60 YEARS; MASSIVE TRANSFUSION; EXSANGUINATION PROTOCOL; PRODUCT UTILIZATION AB Background and Objectives The empiric use of a high plasma to packed red-blood-cell [fresh frozen plasma: red-blood-cells (FFP:RBC)] ratio in trauma resuscitation for patients with massive bleeding has become well accepted without clear or objective indications. Increased plasma transfusion is associated with worse outcome in some patient populations. While previous studies analyse only patients who received a massive transfusion, this study analyses those that are at risk to receive a massive transfusion, based on the trauma-associated severe haemorrhage (TASH) score, to objectively determine which patients after severe trauma would benefit or have increased complications by the use of a high FFP:RBC ratio. Methods Multicentre retrospective study from the Trauma Registry of the German Trauma Society. Multivariate logistic regression and statistical risk adjustments utilized in analyses. Results A high ratio of FFP: RBC in the >= 15 TASH group was independently associated with survival, with an odds ratio of 2.5 (1.6-4.0), while the < 15 TASH group was associated with increased multi-organ failure, 47% vs. 38%, (P < 0.005). Conclusions A predictive model of massive transfusion upon admission might be able to rapidly identify which severe trauma patients would benefit or have increased complications from the immediate application of a high ratio of FFP:RBCs. This study helps to identify the appropriate population for a prospective, interventional trial. C1 [Borgman, M. A.] Childrens Hosp, Boston, MA 02115 USA. [Borgman, M. A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Spinella, P. C.] Blood Syst Res Inst, San Francisco, CA USA. [Holcomb, J. B.; Wade, C. E.] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Blackbourne, L. H.] USA, Inst Surg Res, San Antonio, TX USA. [Lefering, R.; Bouillon, B.; Maegele, M.] Univ Witten Herdecke, CMMC, Cologne, Germany. [Lefering, R.; Maegele, M.] Univ Witten Herdecke, Inst Res Operat Med IFOM, Cologne, Germany. [Lefering, R.; Bouillon, B.; Maegele, M.] TR DGU, Cologne, Germany. RP Borgman, MA (reprint author), Brooke Army Med Ctr, Attn MCHE DP PICU, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM matthew.borgman@us.army.mil RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 FU NHLBI NIH HHS [U01 HL077863, U01 HL077863-07] NR 66 TC 64 Z9 65 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD JUL PY 2011 VL 101 IS 1 BP 44 EP 54 DI 10.1111/j.1423-0410.2011.01466.x PG 11 WC Hematology SC Hematology GA 789VM UT WOS:000292545500007 PM 21438884 ER PT J AU Sandlin, RD Carter, MD Lee, PJ Auschwitz, JM Leed, SE Johnson, JD Wright, DW AF Sandlin, Rebecca D. Carter, Melissa D. Lee, Patricia J. Auschwitz, Jennifer M. Leed, Susan E. Johnson, Jacob D. Wright, David W. TI Use of the NP-40 Detergent-Mediated Assay in Discovery of Inhibitors of beta-Hematin Crystallization SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID HIGH-THROUGHPUT SCREEN; PLASMODIUM-FALCIPARUM; MALARIA PARASITE; HEME CRYSTALLIZATION; ANTIMALARIAL-DRUGS; DIGESTIVE VACUOLE; IN-VITRO; POLYMERIZATION; CHLOROQUINE; IDENTIFICATION AB The protozoan parasite responsible for malaria affects over 500 million people each year. Current antimalarials have experienced decreased efficacy due to the development of drug-resistant strains of Plasmodium spp., resulting in a critical need for the discovery of new antimalarials. Hemozoin, a crystalline by-product of heme detoxification that is necessary for parasite survival, serves as an important drug target. The quinoline antimalarials, including amodiaquine and chloroquine, act by inhibiting the formation of hemozoin. The formation of this crystal does not occur spontaneously, and recent evidence suggests crystallization occurs in the presence of neutral lipid particles located in the acidic digestive vacuole of the parasite. To mimic these conditions, the lipophilic detergent NP-40 has previously been shown to successfully mediate the formation of beta-hematin, synthetic hemozoin. Here, an NP-40 detergent-based assay was successfully adapted for use as a high-throughput screen to identify inhibitors of beta-hematin formation. The resulting assay exhibited a favorable Z' of 0.82 and maximal drift of less than 4%. The assay was used in a pilot screen of 38,400 diverse compounds at a screening concentration of 19.3 mu M, resulting in the identification of 161 previously unreported beta-hematin inhibitors. Of these, 48 also exhibited >= 90% inhibition of parasitemia in a Plasmodium falciparum whole-cell assay at a screening concentration of 23 mu M. Eight of these compounds were identified to have nanomolar 50% inhibitory concentration values near that of chloroquine in this assay. C1 [Sandlin, Rebecca D.; Carter, Melissa D.; Wright, David W.] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA. [Lee, Patricia J.; Auschwitz, Jennifer M.; Leed, Susan E.; Johnson, Jacob D.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Wright, DW (reprint author), Vanderbilt Univ, Dept Chem, Stn B 351822, Nashville, TN 37235 USA. EM David.Wright@vanderbilt.edu FU NIAID [1R01AI83145]; DOD [W81XWH-07-C-0092] FX This work was supported by NIAID grant 1R01AI83145 and DOD W81XWH-07-C-0092. NR 26 TC 39 Z9 39 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2011 VL 55 IS 7 BP 3363 EP 3369 DI 10.1128/AAC.00121-11 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 778FK UT WOS:000291687900038 PM 21518844 ER PT J AU Seetharaman, S Natesan, S Stowers, RS Mullens, C Baer, DG Suggs, LJ Christy, RJ AF Seetharaman, Shanmuganathan Natesan, Shanmugasundaram Stowers, Ryan S. Mullens, Conor Baer, David G. Suggs, Laura J. Christy, Robert J. TI A PEGylated fibrin-based wound dressing with antimicrobial and angiogenic activity SO ACTA BIOMATERIALIA LA English DT Article DE Silver sulfadiazine; Chitosan; PEGylated fibrin gel; Angiogenesis; Adipose-derived stem cells ID SILVER SULFADIAZINE CREAM; STEM-CELLS; MESENCHYMAL STEM; DELIVERY; INFECTIONS; CHITOSAN; ALGINATE; RELEASE; BURNS; DIFFERENTIATION AB Wounds sustained under battlefield conditions are considered to be contaminated and their initial treatment should focus on decreasing this contamination and thus reducing the possibility of infection. The early and aggressive administration of antimicrobial treatment starting with intervention on the battlefield has resulted in improved patient outcomes and is considered the standard of care. Chitosan microspheres (CSM) loaded with silver sulfadiazine (SSD) were developed via a novel water-in-oil emulsion technique to address this problem. The SSD-loaded spheres were porous with needle-like structures (attributed to SSD) that were evenly distributed over the spheres. The average particle size of the SSD-CSM was 125-180 mu m with 76.50 +/- 2.8% drug entrapment. As a potential new wound dressing with angiogenic activity SSD-CSM particles were impregnated in polyethylene glycol (PEGylated) fibrin gels. In vitro drug release studies showed that a burst release of 27.02% in 6 h was achieved, with controlled release for 72 h, with an equilibrium concentration of 27.7% (70 mu g). SSD-CSM-PEGylated fibrin gels were able to exhibit microbicidal activity at 125 and 100 mu g ml(-1) against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. The in vitro vasculogenic activity of this composite dressing was shown by seeding adipose-derived stem cells (ASC) in SSD-CSM-PEGylated fibrin gels. The ASC spontaneously formed microvascular tube-like structures without the addition of any exogenous factors. This provides a method for the extended release of an antimicrobial drug in a matrix that may provide an excellent cellular environment for revascularization of infected wounds. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Seetharaman, Shanmuganathan; Natesan, Shanmugasundaram; Baer, David G.; Christy, Robert J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Stowers, Ryan S.; Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Seetharaman, Shanmuganathan; Natesan, Shanmugasundaram] Pittsburgh Tissue Engn Initiat, Pittsburgh, PA 15219 USA. [Mullens, Conor] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA. RP Christy, RJ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM robert.christy@us.army.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU DRMRP [W81XWH-09-1-0607]; Pittsburgh Tissue Engineering Initiative (PTEI); US Army Medical Research and Materiel Command FX This study was supported by funding from a DRMRP Grant (W81XWH-09-1-0607). The authors would like to thank Dr. David Zamora, Ms. Nicole L. Wrice, and Ms. Sharanda K. Hardy for isolation of adipose tissue and technical support. S. Seetharaman and S. Natesan are supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative (PTEI). The authors thank Dr. Robert Reddick, Medical Director, and Lauren Chesnut, Technical Director of the Electron Microscopy Facility at The University of Texas Health Science Center, Department of Pathology, for use of the facility and assistance in the analysis of electron micrographs. The authors also extend their thanks to TherapeUTex Preclinical Core Lab, Drug Dynamics Institute, College of Pharmacy, University of Texas at Austin for performing the rheology studies.; The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or the US government. The authors are employees of the US government and prepared this work as part of their official duties. All this work was supported by the US Army Medical Research and Materiel Command. NR 42 TC 20 Z9 22 U1 2 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 J9 ACTA BIOMATER JI Acta Biomater. PD JUL PY 2011 VL 7 IS 7 BP 2787 EP 2796 DI 10.1016/j.actbio.2011.04.003 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 785JT UT WOS:000292226000003 PM 21515420 ER PT J AU Harris, MD Yeskey, K AF Harris, Mark D. Yeskey, Kevin TI Bioterrorism and the Vital Role of Family Physicians SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 [Harris, Mark D.] USA, Dept Med, US Dept HHS, Washington, DC 20310 USA. RP Harris, MD (reprint author), USA, Dept Med, US Dept HHS, Washington, DC 20310 USA. EM mark.harris1@hhs.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 1 PY 2011 VL 84 IS 1 BP 18 EP + PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 979ZW UT WOS:000306864400004 PM 21766751 ER PT J AU Pierce, LM Asarias, JR Nguyen, PT Mings, JR Gehrich, AP AF Pierce, Lisa M. Asarias, Jennifer R. Nguyen, Phuoc T. Mings, Jamie R. Gehrich, Alan P. TI Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE coated polypropylene mesh; inflammatory cytokines; matrix metalloproteinases; pelvic organ prolapse; rat model ID SMALL-INTESTINAL SUBMUCOSA; PELVIC ORGAN PROLAPSE; FOREIGN-BODY REACTION; VAGINAL MESH; BIOMATERIALS; SURGERY; REPAIR AB OBJECTIVE: The objective of the study was to compare the influence of collagen-coated vs uncoated polypropylene meshes on the expression of genes critical for wound healing. STUDY DESIGN: In 54 rats, abdominal wall defects were created, repaired by polypropylene sutures, and covered by an overlay of coated polypropylene (n = 20), uncoated polypropylene (n = 18), or no mesh (n = 16). Explants were harvested 7 or 90 days after repair and divided for histological, immunohistochemical, and messenger ribonucleic acid (mRNA) analyses. Real-time quantitative polymerase chain reaction arrays were used to profile the expression of 84 genes at the tissue-mesh interface. RESULTS: One week after implantation, coated mesh elicited a slightly greater inflammatory response and increased mRNA expression of 4 proinflammatory cytokines compared with uncoated mesh. Both materials, however, induced a comparable expression of cytokines and matrix metalloproteinases relative to suture repair 90 days after implantation. CONCLUSION: Collagen-coated polypropylene mesh induces elevated inflammatory cytokine expression compared with uncoated mesh early in the healing process, but the response to both meshes is similar 90 days after implantation. C1 [Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Asarias, Jennifer R.; Nguyen, Phuoc T.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Mings, Jamie R.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. [Gehrich, Alan P.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. FU Victoria S. and Bradley L. Geist Foundation FX This study was supported in part by a Victoria S. and Bradley L. Geist Foundation grant (awarded to L.M.P.). NR 32 TC 4 Z9 4 U1 0 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2011 VL 205 IS 1 AR 82.e1 DI 10.1016/j.ajog.2011.02.045 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 783KX UT WOS:000292082400042 PM 21497787 ER PT J AU Forman, HP Larson, DB Norbash, A Javitt, MC Beauchamp, NJ Monsees, B Messinger, N AF Forman, Howard P. Larson, David B. Norbash, Alexander Javitt, Marcia C. Beauchamp, Norman J., Jr. Monsees, Barbara Messinger, Neil TI Masters of Radiology Panel Discussion: Encouraging and Fostering Mentorship-How We Can Ensure That No Faculty Member Is Left Behind and That Leaders Do Not Fail SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE faculty development; leadership; mentoring C1 [Forman, Howard P.] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA. [Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Monsees, Barbara] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, Breast Imaging Sect, St Louis, MO 63110 USA. [Messinger, Neil] Baptist Hlth Syst, Dept Radiol, Miami, FL USA. RP Forman, HP (reprint author), Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563 NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUL PY 2011 VL 197 IS 1 BP 149 EP 153 DI 10.2214/AJR.11.7090 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 782EO UT WOS:000291991200036 PM 21701023 ER PT J AU Figueiredo, TH Qashu, F Apland, JP Aroniadou-Anderjaska, V Souza, AP Braga, MF AF Figueiredo, T. H. Qashu, F. Apland, J. P. Aroniadou-Anderjaska, V. Souza, A. P. Braga, M. F. TI Efficacy of GluK1 receptor antagonists against soman-induced seizures and neuropathology: a potential new emergency treatment for nerve agent exposure SO AMINO ACIDS LA English DT Meeting Abstract C1 [Figueiredo, T. H.; Qashu, F.; Aroniadou-Anderjaska, V.; Souza, A. P.; Braga, M. F.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Apland, J. P.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0939-4451 J9 AMINO ACIDS JI Amino Acids PD JUL PY 2011 VL 41 SU 1 BP S41 EP S41 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 972JI UT WOS:000306273000130 ER PT J AU Pan, HN Chen, C Jacobowitz, D Van Shura, K Lyman, M McDonough, J Marini, AM AF Pan, Hongna Chen, Cynthia Jacobowitz, David Van Shura, Kerry Lyman, Megan McDonough, John Marini, Ann M. TI Linolenic acid, a dietary supplement, is an efficacious neuroprotective agent against soman-induced brain damage: Its possible use as a preventative strategy SO AMINO ACIDS LA English DT Meeting Abstract C1 [Pan, Hongna; Chen, Cynthia; Jacobowitz, David; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Jacobowitz, David] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Van Shura, Kerry; Lyman, Megan; McDonough, John] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0939-4451 J9 AMINO ACIDS JI Amino Acids PD JUL PY 2011 VL 41 SU 1 BP S42 EP S42 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 972JI UT WOS:000306273000131 ER PT J AU Tran, DD Andersen, CA AF Tran, Daniel D. Andersen, Charles A. TI Axillary Sheath Hematomas Causing Neurologic Complications Following Arterial Access SO ANNALS OF VASCULAR SURGERY LA English DT Article ID BRACHIAL-PLEXUS INJURY; TRANSAXILLARY ARTERIOGRAPHY; NERVE INJURY; CATHETERIZATION; NEUROPATHY; PUNCTURE AB Iatrogenic brachial plexus injuries secondary to expanding hematomas and pseudoaneurysms have been described in limited nature in previously published data. We present the case of a 55-year-old woman who developed neurologic deficits because of a compressive hematoma after axillary arteriography. She underwent emergent exploration of her left arm with decompression of the axillary sheath and brachial artery repair with complete recovery. We describe the presentation, relevant anatomy, and importance of this condition and stress the need for early recognition and surgical intervention to prevent permanent neurologic deficits. C1 [Tran, Daniel D.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. [Andersen, Charles A.] Madigan Army Med Ctr, Vasc & Endovasc Surg Serv, Tacoma, WA 98431 USA. RP Tran, DD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM daniel.tran@us.army.mil NR 17 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD JUL PY 2011 VL 25 IS 5 AR 697.e5 DI 10.1016/j.avsg.2010.12.024 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 786JO UT WOS:000292303400022 PM 21514101 ER PT J AU Lukyanov, AA Segletes, SB AF Lukyanov, Alexander A. Segletes, Steven B. TI Frontiers in the Constitutive Modeling of Anisotropic Shock Waves SO APPLIED MECHANICS REVIEWS LA English DT Review DE anisotropic material; anisotropic plasticity; shock waves; equation of state; stress decomposition AB Studies of anisotropic materials and the discovery of various novel and unexpected phenomena under shock loading has contributed significantly to our understanding of the behavior of condensed matter. The variety of experimental studies for isotropic materials displays systematic patterns, giving basic insights into the underlying physics of anisotropic shock wave modeling. There are many similarities and significant differences in the phenomena observed for isotropic and anisotropic materials under shock-wave loading. Despite this, the anisotropic constitutive equations must represent mathematical and physical generalization of the conventional constitutive equations for isotropic material and reduce to the conventional constitutive equations in the limit of isotropy. This article presents the current state of the art in the constitutive modeling of this fascinating field. [DOI: 10.1115/1.4006253] C1 [Lukyanov, Alexander A.] Abingdon Technol Ctr, Abingdon OX14 1UJ, Oxon, England. [Segletes, Steven B.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lukyanov, AA (reprint author), Abingdon Technol Ctr, Abingdon OX14 1UJ, Oxon, England. NR 74 TC 1 Z9 1 U1 1 U2 13 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0003-6900 J9 APPL MECH REV JI Appl. Mech. Rev. PD JUL PY 2011 VL 64 IS 4 AR 040802 DI 10.1115/1.4006253 PG 13 WC Mechanics SC Mechanics GA V28CG UT WOS:000208658300002 ER PT J AU Eichinger, MJK Bluman, EM Arrington, CED AF Eichinger, Maj Josef K. Bluman, Eric M. Arrington, Col Edward D. TI Penetrating Blast Injury to the Knee of a United States Soldier Treated with Allograft Mosaicplasty SO CARTILAGE LA English DT Article DE mosaicplasty; blast injury; IED; EFP; explosive; open injury AB Objective: This is the first report of successful allograft mosaicplasty treatment of a large osteochondral lesion of the knee caused by a blast fragment sustained during combat operations. The patient was able to return to active duty following rehabilitation. Methods: An active-duty infantryman sustained an osteochondral lesion of the medial femoral condyle caused by a metallic fragment of an explosively formed projectile. Initial treatment consisted of removal of the foreign body and primary closure. The patient continued to experience pain, mechanical symptoms, and repeated effusions after initial nonoperative treatment. Allograft mosaicplasty of the lesion utilizing two 18-mm-diameter fresh allograft osteochondral plugs was performed at 6 months post-injury. Results: At 2-year follow-up, the patient remains on active duty with marked improvement in symptoms. Two years postoperatively, his outcome scores are 72 of 100 on the Western Ontario and McMaster University osteoarthritis scoring index (WOMAC) and 60 of 100 on the Knee Injury and Osteoarthritis Outcome Score (KOOS). His follow-up x-rays and MRI demonstrate intact articular cartilage and subchondral bone incorporation. Conclusion: Penetrating injuries to joints are commonplace in the battlefield environment. Combat injuries to the knee are frequently associated with articular cartilage injury. While numerous cartilage restoration techniques have been used with success for the treatment of osteochondral injuries to the femoral condyles, no published reports describe the use of allograft mosaicplasty in this location for open, penetrating injuries with focal cartilage loss. This is the first documented use of allograft mosaicplasty for a traumatic osteochondral defect of the medial femoral condyle caused by a metallic projectile. The patient was able to return to active duty following rehabilitation. We demonstrate a high level of functioning is possible following allograft mosaicplasty of a large osteochondral lesion caused by penetrating ballistic trauma. C1 [Eichinger, Maj Josef K.] Womack Army Med Ctr, Dept Orthopaed, Ft Bragg, NC 28310 USA. [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthopaed, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA USA. RP Eichinger, MJK (reprint author), Womack Army Med Ctr, Dept Orthopaed, Ft Bragg, NC 28310 USA. EM joe.eichinger@gmail.com FU United States Military FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. The authors thank Allosource for their continuing support of the United States Military and its service members. The authors received no financial support for the research and/or authorship of this article. NR 26 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1947-6035 EI 1947-6043 J9 CARTILAGE JI Cartilage PD JUL PY 2011 VL 2 IS 3 BP 307 EP 311 DI 10.1177/1947603510392024 PG 5 WC Orthopedics SC Orthopedics GA V36NC UT WOS:000209217500010 PM 26069589 ER PT J AU Kijak, GH Beyrer, C Tovanabutra, S Sripaipan, T Suriyanon, V Moqueet, N Sanders-Buell, E Saokhieo, P Timpan, U Jittiwutikarn, J Robb, ML Birx, DL Celentano, DD McCutchan, FE AF Kijak, G. H. Beyrer, C. Tovanabutra, S. Sripaipan, T. Suriyanon, V. Moqueet, N. Sanders-Buell, E. Saokhieo, P. Timpan, U. Jittiwutikarn, J. Robb, M. L. Birx, D. L. Celentano, D. D. McCutchan, F. E. TI Socio-demographic and drug use factors associated with HIV-1 recombinants and dual infections in Northern Thai drug users: Associations of risk with genetic complexity SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Injection drug use; HIV/AIDS; Recombination; Dual infection; Molecular epidemiology; Injecting risk; Thailand; Multi-region hybridization assay ID MBEYA REGION; MOLECULAR EPIDEMIOLOGY; DIVERSITY; TYPE-1; INJECTION; TANZANIA; SUBTYPES; BANGKOK; SUPERINFECTION; PROGRESSION AB Background: Dual infection with diverse HIV strains can foster the emergence of recombinants. The resulting increase in viral genetic diversity is a major challenge for vaccine development HIV treatment. In this study we aim to investigate the socio demographic factors associated with an increasing level of genetic diversity among HIV strains in a population of drug-users in Northern Thailand. Methods: From 1999 through 2000,2231 volunteers were enrolled in the Opiate-Users Research in Chiang Mai, Thailand. HIV subtype analysis was conducted among those HIV-1 seropositive (n = 347) using a multi-region hybridization assay. Social and demographic variables were assessed using a structured questionnaire. Results: Overall, 336/347 (96.8%) of the samples could be typed. 81.8% were CRF01_AE, 3.9% were subtype B, 9.2% were recombinants (mostly between CRF01_AE and B) and 5.1% were dual infections. Dual infections were more frequent among those with a lower education level (AOR: 5.2; 95% Cl 1.4-20.3), those who have initiated injecting in the last 3 years (AOR: 3.9; 95% Cl 1.1-14.6), and those reporting frequent needle sharing in the last 3 months (AOR: 7.0; 95% Cl 1.5-34.1). Both recombinant strains and dual infection were more frequent among those reporting frequent needle sharing in the last 3 months (AOR: 5.3; 95% CI 1.6-17.1). Conclusion: To limit the expanding complexity of HIV-1 strains, early intervention should be aimed at reduction in needle sharing, especially among new intravenous drug users. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Kijak, G. H.; Birx, D. L.] Henry M Jackson Fdn, US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Beyrer, C.; Sripaipan, T.; Celentano, D. D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Suriyanon, V.; Saokhieo, P.; Timpan, U.] Res Inst Hlth Sci, Chiang Mai 50202, Thailand. [Jittiwutikarn, J.] No Drug Treatment Ctr, Chiang Mai 50180, Thailand. RP Kijak, GH (reprint author), Henry M Jackson Fdn, US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM drkijak@gmail.com FU Henry M Jackson Foundation for the Advancement of Military Medicine; U.S. Department of Defense; National Institutes of Health, Bethesda, MD [1 R01 DA 11133] FX This work was partly supported by a cooperative agreement between the Henry M Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense, and partly by grants (1 R01 DA 11133, and a competitive supplement from the Office of AIDS Research) from the National Institutes of Health, Bethesda, MD. The views and opinions expressed herein do not necessarily reflect those of the U.S. Army or of the Department of Defense. NR 29 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD JUL 1 PY 2011 VL 116 IS 1-3 BP 24 EP 30 DI 10.1016/j.drugalcdep.2010.11.013 PG 7 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 784SY UT WOS:000292179700005 PM 21193272 ER PT J AU Berge, ND Ro, KS Mao, JD Flora, JRV Chappell, MA Bae, SY AF Berge, Nicole D. Ro, Kyoung S. Mao, Jingdong Flora, Joseph R. V. Chappell, Mark A. Bae, Sunyoung TI Hydrothermal Carbonization of Municipal Waste Streams SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID STATE NMR-SPECTROSCOPY; SOLID-WASTE; CHEMICAL-REACTIONS; PLANT-MATERIAL; CELLULOSE; PRODUCTS; WATER; BIOMASS; LIQUID AB Hydrothermal carbonization (HTC) is a novel thermal conversion process that can be used to convert municipal waste streams into sterilized, value-added hydrochar. HTC has been mostly applied and studied on a limited number of feedstocks, ranging from pure substances to slightly more complex biomass such as wood, with an emphasis on nanostructure generation. There has been little work exploring the carbonization of complex waste streams or of utilizing HTC as a sustainable waste management technique. The objectives of this study were to evaluate the environmental implications associated with the carbonization of representative municipal waste streams (including gas and liquid products), to evaluate the physical, chemical, and thermal properties of the produced hydrochar, and to determine carbonization energetics associated with each waste stream. Results from batch carbonization experiments indicate 49-75% of the initially present carbon is retained within the char, while 20-37% and 2-11% of the carbon is transferred to the liquid- and gas-phases, respectively. The composition of the produced hydrochar suggests both dehydration and decarboxylation occur during carbonization, resulting in structures with high aromaticities. Process energetics suggest feedstock carbonization is exothermic. C1 [Berge, Nicole D.; Flora, Joseph R. V.] Univ S Carolina, Dept Civil & Environm Engn, Columbia, SC 29208 USA. [Ro, Kyoung S.] ARS, USDA, Coastal Plains Soil Water & Plant Res Ctr, Florence, SC 29501 USA. [Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Chappell, Mark A.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [Bae, Sunyoung] Seoul Womens Univ, Dept Chem, Seoul 139774, South Korea. RP Berge, ND (reprint author), Univ S Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA. EM berge@cec.sc.edu FU National Science Foundation [EAR-0843996, CBET-0853950] FX The authors acknowledge the contributions of Ms. Beth Quattlebaum for conducting AD waste experiments and Ms. Paula Lozano for obtaining TOC data. Mao would like to thank the National Science Foundation (EAR-0843996 and CBET-0853950) for the support of his research. Collaboration with the USDA-ARS was conducted according to the agreement NFCA 6657-13630-003-14N. Mention of trade names or commercial products is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture. NR 37 TC 129 Z9 136 U1 19 U2 160 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 1 PY 2011 VL 45 IS 13 BP 5696 EP 5703 DI 10.1021/es2004528 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 783IQ UT WOS:000292075100035 PM 21671644 ER PT J AU Nayfeh, OM AF Nayfeh, Osama M. TI Heterojunction Tunneling Transistors Using Gate-Controlled Tunneling Across Silicon-Germanium/Silicon Epitaxial Thin Films SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Heterojunction; SiGe; tunnel transistors AB Tunneling transistors that incorporate in the gated source an elevated p+ Si(0.6) Ge(0.4)/n(-) Si heterojunction and a HfO(2)/WN gate stack are constructed. XTEM images show intact epitaxial SiGe with sub-10-nm thickness. The current/voltage characteristics within 77 K-300 K show behavior consistent with gate-controlled tunneling over several decades of current. Simulations using a nonlocal tunneling model support a tunneling process that occurs across the heterojunction. There is sufficient gate modulation of the surface potential at the p(+) SiGe/gate-insulator interface to provide the band overlap and band bending for band-to-band tunneling (BTBT). The transfer and output characteristics are considerably improved over previous devices that used buried SiGe films, ion-implanted junctions, and SiO(2) dielectrics, resulting in a reduced minimum subthreshold slope and an increased current drive with identical biasing. Also, due to the asymmetry in this structure and suppression of drain BTBT, I(on)/I(off) > 10(5) is achieved with V(dd) = 2.5 V. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Nayfeh, OM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM osama.nayfeh@us.army.mil FU ARL; DARPA FX Manuscript received March 14, 2011; accepted April 7, 2011. Date of publication June 2, 2011; date of current version June 29, 2011. The work was supported in part by ARL and in part by DARPA. The review of this letter was arranged by Editor M. Ostling. NR 12 TC 2 Z9 2 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JUL PY 2011 VL 32 IS 7 BP 844 EP 846 DI 10.1109/LED.2011.2147273 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 784NY UT WOS:000292165200004 ER PT J AU Chen, Y Nasrabadi, NM Tran, TD AF Chen, Yi Nasrabadi, Nasser M. Tran, Trac D. TI Simultaneous Joint Sparsity Model for Target Detection in Hyperspectral Imagery SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Hyperspectral imagery; joint sparsity model; simultaneous orthogonal matching pursuit; sparse representation; target detection ID LINEAR INVERSE PROBLEMS; ALGORITHMS; CLASSIFICATION; PURSUIT AB This letter proposes a simultaneous joint sparsity model for target detection in hyperspectral imagery (HSI). The key innovative idea here is that hyperspectral pixels within a small neighborhood in the test image can be simultaneously represented by a linear combination of a few common training samples but weighted with a different set of coefficients for each pixel. The joint sparsity model automatically incorporates the interpixel correlation within the HSI by assuming that neighboring pixels usually consist of similar materials. The sparse representations of the neighboring pixels are obtained by simultaneously decomposing the pixels over a given dictionary consisting of training samples of both the target and background classes. The recovered sparse coefficient vectors are then directly used for determining the label of the test pixels. Simulation results show that the proposed algorithm outperforms the classical hyperspectral target detection algorithms, such as the popular spectral matched filters, matched subspace detectors, and adaptive subspace detectors, as well as binary classifiers such as support vector machines. C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. EM ychen98@jhu.edu; trac@jhu.edu FU Army Research Office [58110-MA-II]; National Science Foundation [CCF-0728893] FX Manuscript received May 17, 2010; revised September 23, 2010 and November 12, 2010; accepted December 9, 2010. Date of publication January 30, 2011; date of current version June 24, 2011. This work was supported in part by the Army Research Office under Grant 58110-MA-II and the National Science Foundation under Grant CCF-0728893. NR 14 TC 44 Z9 57 U1 4 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JUL PY 2011 VL 8 IS 4 BP 676 EP 680 DI 10.1109/LGRS.2010.2099640 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 783SW UT WOS:000292105300019 ER PT J AU Grzegorczyk, TM Barrowes, BE Shubitidze, F Fernandez, JP O'Neill, K AF Grzegorczyk, Tomasz M. Barrowes, Benjamin E. Shubitidze, Fridon Fernandez, Juan Pablo O'Neill, Kevin TI Simultaneous Identification of Multiple Unexploded Ordnance Using Electromagnetic Induction Sensors SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Electromagnetic induction; Gauss-Newton method; subsurface sensing; unexploded ordnance (UXO) ID INDEPENDENT COMPONENT ANALYSIS; METALLIC OBJECTS; ARBITRARY EXCITATION; UXO DETECTION; DISCRIMINATION; TARGETS; SCATTERING; SURFACE; MODEL AB The simultaneous detection and identification of multiple targets using electromagnetic induction (EMI) time-domain sensors remains a challenge due to the fast decay of the magnetic field with sensor-target distance. For example, the signal from a weak yet shallow target or clutter item can overshadow that from a much larger yet deeper unexploded ordnance (UXO), potentially resulting in erroneous localization and/or identification. We propose, in this paper, a method based on the Gauss-Newton algorithm for the inversion of multiple targets within the field of view of sensors operating at EMI frequencies (tens of hertz to a few hundred kilohertz). In order to minimize the number of unknowns to invert for, the polarizability tensor is written as a time-independent orientation matrix multiplied by a time-dependent diagonal intrinsic polarizability tensor. Similarly, position is supposed to be time independent so that both position and orientation angles are inverted only once using all time channels collected by the instrument. Moreover, using the dipole approximation, we are able to compute the Jacobian in closed form for instruments with either square or circular primary field coils, thus contributing to the speed of the algorithm. Validating results are shown based on the measurement data collected with two EMI sensors on various types of UXO. C1 [Grzegorczyk, Tomasz M.] Delpsi LLC, Newton, MA 02458 USA. [Barrowes, Benjamin E.; O'Neill, Kevin] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Fernandez, Juan Pablo] Dartmouth Coll, Thayer Sch Engn, Electromagnet Sensing Grp, Hanover, NH 03755 USA. RP Grzegorczyk, TM (reprint author), Delpsi LLC, Newton, MA 02458 USA. EM tomasz.grzegorczyk@delpsi.com; benjamin.e.barrowes@usace.army.mil; fridon.shubitidze@dartmouth.edu; Juan.Pablo.Fernandez@Dartmouth.edu; kevin.o'neill@erdc.usace.army.mil FU Strategic Environmental Research and Development Program [MM-1664] FX This work was supported by the Strategic Environmental Research and Development Program through Grant MM-1664. NR 35 TC 15 Z9 15 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUL PY 2011 VL 49 IS 7 BP 2507 EP 2517 DI 10.1109/TGRS.2011.2108302 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 783VJ UT WOS:000292111800004 ER PT J AU Ren, W Zhao, Q Swami, A AF Ren, Wei Zhao, Qing Swami, Ananthram TI Connectivity of Heterogeneous Wireless Networks SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE Cognitive radio; connectivity region; continuum percolation; critical densities; heterogeneous wireless network; phase transition ID COGNITIVE RADIO NETWORKS; PERCOLATION AB We address the percolation-based connectivity of large-scale ad hoc heterogeneous wireless networks, where secondary users exploit channels temporarily unused by primary users and the existence of a communication link between two secondary users depends on not only the distance between them but also the transmitting and receiving activities of nearby primary users. We introduce the concept of connectivity region defined as the set of density pairs-the density of secondary users and the density of primary transmitters - under which the secondary network is connected. Using theories and techniques from continuum percolation, we analytically characterize the connectivity region of the secondary network and reveal the tradeoff between proximity (the number of neighbors) and the occurrence of spectrum opportunities. Specifically, we establish three basic properties of the connectivity region-contiguity, monotonicity of the boundary and uniqueness of the infinite connected component, where the uniqueness implies the occurrence of a phase transition phenomenon in terms of the almost sure existence of either zero or one infinite connected component; we identify and analyze two critical densities which jointly specify the profile as well as an outer bound on the connectivity region; we study the impacts of secondary users' transmission power on the connectivity region and the conditional average degree of a secondary user and demonstrate that matching the interference ranges of the primary and the secondary networks maximizes the tolerance of the secondary network to the primary traffic load. Furthermore, we establish a necessary condition and a sufficient condition for connectivity, which lead to an outer bound and an inner bound on the connectivity region. C1 [Ren, Wei; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Ren, W (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM wren@ucdavis.edu; qzhao@ucdavis.edu; a.swami@ieee.org FU Army Research Office [W911NF-08-1-0467]; National Science Foundation [CCF-0830685] FX This work was supported in part by the Army Research Office under Grant W911NF-08-1-0467 and by the National Science Foundation under Grant CCF-0830685. NR 26 TC 31 Z9 32 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 EI 1557-9654 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD JUL PY 2011 VL 57 IS 7 BP 4315 EP 4332 DI 10.1109/TIT.2011.2145650 PG 18 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 781HW UT WOS:000291922500019 ER PT J AU Chen, JYC Barnes, MJ Harper-Sciarini, M AF Chen, Jessie Y. C. Barnes, Michael J. Harper-Sciarini, Michelle TI Supervisory Control of Multiple Robots: Human-Performance Issues and User-Interface Design SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Review DE Human-agent teams; human-robot interaction (HRI); levels of automation (LOAs); robotics control; supervisory control; unmanned vehicles; user-interface design ID SIMULATED MULTITASKING ENVIRONMENT; HUMAN-MACHINE SYSTEMS; CONCURRENT PERFORMANCE; SITUATION AWARENESS; IMPERFECT AUTOMATION; ADAPTIVE AUTOMATION; TASK; VEHICLES; AGENT; RELIANCE AB The purpose of this paper is to review research pertaining to the limitations and advantages of supervisory control for unmanned systems. We identify and discuss results showing technologies that mitigate the observed problems such as specialized interfaces, and adaptive systems. In the report, we first present an overview of definitions and important terms of supervisory control and human-agent teaming. We then discuss human performance issues in supervisory control of multiple robots with regard to operator multitasking performance, trust in automation, situation awareness, and operator workload. In the following sections, we review research findings for specific areas of supervisory control of multiple ground robots, aerial robots, and heterogeneous robots (using different types of robots in the same mission). In the last section, we review innovative techniques and technologies designed to enhance operator performance and reduce potential performance degradations identified in the literature. C1 [Chen, Jessie Y. C.; Barnes, Michael J.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Harper-Sciarini, Michelle] APRISE LLC, Winter Springs, FL 32708 USA. RP Chen, JYC (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jessie.chen@us.army.mil; michael.barnes@hua.army.mil; mharper-sciarini@knights.ucf.edu FU U.S. Army FX This work was supported by the U.S. Army's Army Technology Objective (ATO): Safe Operations of Unmanned Reconnaissance in Complex Environments (SOURCE). This paper was recommended by Associate Editor P. J. Sanz. NR 144 TC 28 Z9 28 U1 2 U2 26 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6977 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD JUL PY 2011 VL 41 IS 4 BP 435 EP 454 DI 10.1109/TSMCC.2010.2056682 PG 20 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 780AL UT WOS:000291823300002 ER PT J AU Xu, JL Su, W Zhou, MC AF Xu, Jefferson L. Su, Wei Zhou, Mengchu TI Likelihood-Ratio Approaches to Automatic Modulation Classification SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Review DE Cognitive radio; likelihood ratio test (LRT); maximum likelihood (ML); modulation classification; modulation recognition; software-defined radio (SDR); wireless communication systems ID SIGNAL CLASSIFICATION; NOISE; CHANNEL AB Adaptive modulation and automatic modulation classification are highly demanded in software-defined radio (SDR) for both commercial and military applications. Various design options of automatic classifiers have attracted researchers in developing 3G and 4G wireless communication systems. There is an urgent need to investigate the different methods of coherent and noncoherent modulation estimations, discuss the challenges in cooperative and noncooperative communication environment, and understand the distinct requirements in real-time modulation classifications. This survey paper focuses on the automatic modulation classification methods based on likelihood functions, studies various classification solutions derived from likelihood ratio test, and discusses the detailed characteristics associated with all major algorithms. C1 [Xu, Jefferson L.; Zhou, Mengchu] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. [Su, Wei] USA, CERDEC, Ft Monmouth, NJ 07703 USA. RP Xu, JL (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. EM jxuly@yahoo.com; wei.su@us.army.mil; zhou@njit.edu NR 70 TC 42 Z9 50 U1 2 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6977 EI 1558-2442 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD JUL PY 2011 VL 41 IS 4 BP 455 EP 469 DI 10.1109/TSMCC.2010.2076347 PG 15 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 780AL UT WOS:000291823300003 ER PT J AU Webb, L Petersen, M Boden, S LaBelle, V Bird, JA Howell, D Burks, AW Laubach, S AF Webb, Luke Petersen, Maureen Boden, Stephen LaBelle, Virginia Bird, J. Andrew Howell, Druhan Burks, A. Wesley Laubach, Susan TI Single-dose influenza vaccination of patients with egg allergy in a multicenter study SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter C1 [Webb, Luke; Petersen, Maureen; Laubach, Susan] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. [Boden, Stephen; LaBelle, Virginia; Burks, A. Wesley] Duke Univ, Med Ctr, Dept Pediat, Div Allergy Immunol, Durham, NC 27710 USA. [Bird, J. Andrew] Univ Texas SW Med Ctr Dallas, Dept Allergy Immunol, Dallas, TX 75390 USA. [Howell, Druhan] Univ S Alabama, Dept Allergy Immunol, Mobile, AL 36688 USA. RP Webb, L (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. EM Susan.Laubach@us.army.mil OI Bird, John/0000-0003-3772-6078 FU NIAID NIH HHS [T32 AI007062, 5T32-AI007062-32] NR 10 TC 22 Z9 23 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JUL PY 2011 VL 128 IS 1 BP 218 EP 219 DI 10.1016/j.jaci.2011.02.013 PG 3 WC Allergy; Immunology SC Allergy; Immunology GA 785RE UT WOS:000292245600031 PM 21459425 ER PT J AU Everitt, JH Yang, CH Summy, KR Glomski, LM Owens, CS AF Everitt, James H. Yang, Chenghai Summy, Kenneth R. Glomski, Leeann M. Owens, Chetta S. TI Evaluation of hyperspectral reflectance data for discriminating six aquatic weeds SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic weeds; Hydrilla verticillata; hyperspectral reflectance; multiple comparison range test; Myriophyllum aquaticum; Myriophyllum sibiricum; Myriophyllum spicatum; Myriophyllum spicatum x Myriophyllum sibiricum; Potamogeton crispus; spectral signature; stepwise discriminant analysis AB In situ hyperspectral reflectance data were studied at 50 wavebands (10 nm bandwidth) in the 400 to 900 nm spectral range to determine their potential for discriminating among 6 aquatic weed species: curly-leaf pondweed (Potamogeton crispus L.), hydrilla (Hydrilla verticillata [L.F.] Royle), Eurasian watermilfoil (Myriophyllum spicatum L.), northern milfoil (Myriophyllum sibiricum Kom.), hybrid milfoil (Myriophyllum spicatum * Myriophyllum sibiricum), and parrotfeather (Myriophyllum aquaticum [J.M. da Conceicao] Vellozo). The species were studied on 3 dates: May 11, May 30, and July 1, 2009. All 6 species were studied on the 2 May dates, while only 4 species (hydrilla, Eurasian watermilfoil, hybrid milfoil, and parrotfeather) were studied on the July date. To determine the optimum bands for discriminating among the species, 2 procedures were used: multiple comparison range test and step-wise discriminant analysis. Multiple comparison range test results for both May dates showed that most separations among species occurred at bands in the green-red edge, red, and red near-infrared (NIR) edge spectral regions. For the July date, the largest number of separations among species occurred at all green and most red bands, as well as some red-NIR edge and NIR bands. Using stepwise discriminant analysis, 9 bands for May 11 and 10 bands for May 30 in the blue to NIR spectral regions had the highest power of discrimination among the 6 species. For the July date, 7 bands in the red-NIR edge and NIR regions were useful for discriminating among the 4 species. C1 [Everitt, James H.; Yang, Chenghai] USDA ARS, Weslaco, TX 78596 USA. [Summy, Kenneth R.] Univ Texas Pan Amer, Dept Biol, Edinburg, TX 78539 USA. [Glomski, Leeann M.; Owens, Chetta S.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Everitt, JH (reprint author), USDA ARS, 2413 E Highway 83, Weslaco, TX 78596 USA. EM james.everitt@ars.usda.gov NR 28 TC 2 Z9 2 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2011 VL 49 BP 94 EP U119 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UK UT WOS:000209043500006 ER PT J AU Netherland, MD AF Netherland, Michael D. TI Comparative susceptibility of fluridone resistant and susceptible hydrilla to four ALS inhibiting herbicides under laboratory and greenhouse conditions SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic herbicides; bensulfuron-methyl; bispyribac-sodium; chemical control; imazamox; penoxsulam; submersed invasive plants AB In response to the widespread presence of fluridone resistant strains of dioecious hydrilla (Hydrilla verticillata [L.f.] Royle) throughout Florida, several new herbicides, including acetolactate synthase (ALS) inhibitors, are being evaluated for aquatic registration. Laboratory and greenhouse studies were conducted to determine the susceptibility of different hydrilla populations in Florida to 4 ALS inhibitors. Apical shoots of fluridone-resistant and fluridone-susceptible strains of hydrilla collected from 6 Florida lakes were placed in growth chambers and exposed to the ALS inhibitors bensulfuron-methyl, bispyribac-sodium, imazamox, and penoxsulam at concentrations of 0, 2.5, 5, 10, 25, 50, and 100 pg active ingredient (a.i.) per liter. Two of these hydrilla accessions were then established in 90 L tanks in a greenhouse and exposed for 8 weeks to the 4 ALS herbicides at concentrations of 0, 5, 10, 25, 50, and 100 mu g L-1. Results from both the laboratory and greenhouse studies suggest that different strains of dioecious hydrilla collected throughout Florida (including fluridone-resistant strains) show similar susceptibility to each individual ALS herbicide. Bensulfuron methyl and penoxsulam were the most active compounds with a significant increase in activity noted between 5 and 10 mu g L-1. Activity of bispyribac sodium showed a strong increase between 10 and 25 mu g L-1. No differences in activity were detected within or between these 3 herbicides at concentrations of 25, 50, and 100 mu g L-1. In contrast, imazamox efficacy generally increased with concentration. The 4 ALS herbicides differed in the concentration required to elicit a threshold or phytotoxic response by hydrilla, but all showed similar activity against different accessions of hydrilla. While treatment symptoms and hydrilla response could not be distinguished between bensulfuron methyl, bispyribac sodium, and penoxsulam, imazamox consistently resulted in different symptoms and rate response. Results from the laboratory assays were predictive of the results obtained in the longer term and larger scale greenhouse trials. This baseline susceptibility data can be used to determine if increased tolerance to ALS herbicides occurs over time. These studies suggest that ALS inhibitors can result in rapid growth cessation, but generally slow control of existing hydrilla biomass. C1 US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM Michael.D.Nether-land@usace.army.mil FU US Army Engineer Research and Development Center Aquatic Plant Control Research Program; Florida Fish and Wildlife Conservation Commission; Osceola County Hydrilla Control Demonstration Project FX The author would like to thank Michael Aldridge and Petra Aldridge for technical assistance. Support for this project was provided by the US Army Engineer Research and Development Center Aquatic Plant Control Research Program, the Florida Fish and Wildlife Conservation Commission, and the Osceola County Hydrilla Control Demonstration Project. Permission to publish this information was granted by the Chief of Engineers. Citation of trade names does not constitute an official endorsement or approval of the use of such commercial products. NR 26 TC 4 Z9 4 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2011 VL 49 BP 100 EP U126 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UK UT WOS:000209043500007 ER PT J AU Harms, NE Grodowitz, MJ AF Harms, Nathan E. Grodowitz, Michael J. TI Overwintering biology of Hydrellia pakistanae, a biological control agent of hydrilla SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Harms, Nathan E.; Grodowitz, Michael J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Harms, NE (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Nathan.E.Harms@usace.army.mil FU US Army Corps of Engineers Aquatic Plant Control Research Program FX This work was funded by the US Army Corps of Engineers Aquatic Plant Control Research Program, under the leadership of the technical director, Alfred F. Cofrancesco. We would like to thank Dr. Wayne Mathis for verification of Hydrellia sp. as well as Drs. Lubomir Masner and Bob Kula for parasitoid identifications and Ms. Julie Nachtrieb, who aided in collections. We also thank the comments and suggestions of two anonymous reviewers. Permission to publish this information was granted by the Chief of Engineers. NR 17 TC 4 Z9 4 U1 2 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2011 VL 49 BP 114 EP 117 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UK UT WOS:000209043500010 ER PT J AU Shearer, JF Durham, BD Harms, N AF Shearer, Judy F. Durham, Brian D. Harms, Nathan TI Screening of biological control pathogens isolated from Eurasian watermilfoil SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Shearer, Judy F.; Durham, Brian D.; Harms, Nathan] US Army, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Shearer, JF (reprint author), US Army, Corps Engineers, Ctr Res & Dev, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Judy.F.Shearer@usace.army.mil FU USACE Engineer Research and Development Center, Environmental Laboratory, Aquatic Plant Control Research Program (Vicksburg, MS) FX Support for this manuscript came from the USACE Engineer Research and Development Center, Environmental Laboratory, Aquatic Plant Control Research Program (Vicksburg, MS). Permission was granted by the Chief of Engineers to publish this information. The authors would like to thank Jen Marvin, Emily and Mark Stevenson, Jen Parsons, Ray Newman, Chip Welling, Tom Flannery, Larry Eichler, Laurie Callahan, Ann Bove, Greg Pitchford, Kim Bogenschutz, and Robert Kaul for field assistance. NR 21 TC 0 Z9 0 U1 2 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2011 VL 49 BP 118 EP 121 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UK UT WOS:000209043500011 ER PT J AU Frech, CB Coppola, BP Harris, H Woodbridge, CM AF Frech, Cheryl B. Coppola, Brian P. Harris, Hal Woodbridge, C. M. TI Summer 2011 Book and Media Recommendations SO JOURNAL OF CHEMICAL EDUCATION LA English DT Editorial Material DE General Public; History/Philosophy; Interdisciplinary/Multidisciplinary; Public Understanding/Outreach AB This is a list of recommendations for books, including a graphic novel and fiction titles, and two DVDs for Journal readers to enjoy in the summer, either in preparation for fall teaching, or for sheer pleasure. Four contributors have assembled an eclectic list in this annual collection. C1 [Frech, Cheryl B.] Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. [Coppola, Brian P.] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA. [Harris, Hal] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA. [Woodbridge, C. M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Frech, CB (reprint author), Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. EM cfrech@uco.edu RI Coppola, Brian P/G-3709-2016 OI Coppola, Brian P/0000-0001-7226-0942 NR 28 TC 0 Z9 0 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JUL PY 2011 VL 88 IS 7 BP 851 EP 857 DI 10.1021/ed200253m PG 7 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 781TM UT WOS:000291959400003 ER PT J AU Ruang-areerate, T Jeamwattanalert, P Rodkvamtook, W Richards, AL Sunyakumthorn, P Gaywee, J AF Ruang-areerate, Toon Jeamwattanalert, Pimmada Rodkvamtook, Wuttikorn Richards, Allen L. Sunyakumthorn, Piyanate Gaywee, Jariyanart TI Genotype Diversity and Distribution of Orientia tsutsugamushi Causing Scrub Typhus in Thailand SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID RICKETTSIA-TSUTSUGAMUSHI; INDIRECT IMMUNOFLUORESCENCE; PHYLOGENETIC ANALYSIS; SEQUENCE HOMOLOGIES; ANTIGENIC VARIANTS; IDENTIFICATION; STRAINS; GENES; CLASSIFICATION; TROMBICULIDAE AB Scrub typhus, caused by antigenically disparate isolates of Orientia tsutsugamushi, is a widely distributed mite-borne human disease in the Asia Pacific region. Information regarding the heterogeneity of the immunodominant 56-kDa type-specific antigen (TSA) gene is crucial for the design and evaluation of scrub typhus-specific diagnostic assays and vaccines. Using indirect immunofluorescence assays (IFA) and PCR assays, O. tsutsugamushi was detected samples from rodents and patients with fever of unknown origin obtained from six provinces of Thailand during 2004 to 2007. Sequences were determined for a fragment of the 56-kDa TSA gene, and the relationship between these sequences and those previously determined were assessed. The phylogenetic analyses of partial 56-kDa TSA gene sequences demonstrated wide diversity and distribution of O. tsutsugamushi genotypes in Thailand. Furthermore, the genetic diversity grouped the scrub typhus agents into two commonly and five infrequently found genotypes within six provinces of Thailand. The two most commonly found genotypes of O. tsutsugamushi described in this study do not associate with the prototype strains that are widely used for the design and evaluation of diagnostic assays and vaccine candidates. Thus, these new genotypes should be considered for future scrub typhus assay and vaccine development. C1 [Ruang-areerate, Toon] Armed Forces Res Inst Med Sci, Epidemiol Sect, Div Res, Bangkok 10400, Thailand. [Jeamwattanalert, Pimmada] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Richards, Allen L.] USN, Viral & Rickettsial Dis Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Sunyakumthorn, Piyanate] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA. RP Ruang-areerate, T (reprint author), Armed Forces Res Inst Med Sci, Epidemiol Sect, Div Res, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM toonr@afrims.go.th RI Valle, Ruben/A-7512-2013 FU Thanphuying Viraya Chavakul Foundation for Medical Armed Forces; Thailand Tropical Diseases Research Funding Program [T-2]; Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center FX This work was supported by a Thanphuying Viraya Chavakul Foundation for Medical Armed Forces Research grant (2008 to 2009) and the Thailand Tropical Diseases Research Funding Program (T-2). Part of this work (by A. L. R.) was supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. NR 31 TC 12 Z9 13 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2011 VL 49 IS 7 BP 2584 EP 2589 DI 10.1128/JCM.00355-11 PG 6 WC Microbiology SC Microbiology GA 786BC UT WOS:000292276200032 PM 21593255 ER PT J AU Whitaker, KW Neumeister, H Huffman, LS Kidd, CE Preuss, T Hofmann, HA AF Whitaker, K. W. Neumeister, H. Huffman, L. S. Kidd, C. E. Preuss, T. Hofmann, H. A. TI Serotonergic modulation of startle-escape plasticity in an African cichlid fish: a single-cell molecular and physiological analysis of a vital neural circuit SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article DE Mauthner cell; single-cell polymerase chain reaction; Astatotilapia burtoni; 5-HT receptor subtype 2; ketanserin ID CENTRAL INHIBITORY SYNAPSES; GOLDFISH CARASSIUS-AURATUS; 5-HT5A RECEPTOR GENE; MAUTHNER CELL; DECISION-MAKING; CDNA MICROARRAY; MIXED SYNAPSES; SENSORIMOTOR INTEGRATION; FUNCTIONAL GENOMICS; QUANTAL RELEASE AB Whitaker KW, Neumeister H, Huffman LS, Kidd CE, Preuss T, Hofmann HA. Serotonergic modulation of startle-escape plasticity in an African cichlid fish: a single-cell molecular and physiological analysis of a vital neural circuit. J Neurophysiol 106: 127-137, 2011. First published March 30, 2011; doi:10.1152/jn.01126.2010.-Social life affects brain function at all levels, including gene expression, neurochemical balance, and neural circuits. We have previously shown that in the cichlid fish Astatotilapia burtoni brightly colored, socially dominant (DOM) males face a trade-off between reproductive opportunities and increased predation risk. Compared with camouflaged subordinate (SUB) males, DOMs exposed to a loud sound pip display higher startle responsiveness and increased excitability of the Mauthner cell (M-cell) circuit that governs this behavior. Using behavioral tests, intracellular recordings, and single-cell molecular analysis, we show here that serotonin (5-HT) modulates this socially regulated plasticity via the 5-HT receptor subtype 2 (5-HTR(2)). Specifically, SUBs display increased sensitivity to pharmacological manipulation of 5-HTR(2) compared with DOMs in both startle-escape behavior and electrophysiological properties of the M-cell. Immunohistochemistry showed serotonergic varicosities around the M-cells, further suggesting that 5-HT impinges directly onto the startle-escape circuitry. To determine whether the effects of 5-HTR(2) are pre- or postsynaptic, and whether other 5-HTR subtypes are involved, we harvested the mRNA from single M-cells via cytoplasmic aspiration and found that 5-HTR subtypes 5A and 6 are expressed in the M-cell. 5-HTR(2), however, was absent, suggesting that it affects M-cell excitability through a presynaptic mechanism. These results are consistent with a role for 5-HT in modulating startle plasticity and increase our understanding of the neural and molecular basis of a trade-off between reproduction and predation. C1 [Huffman, L. S.; Kidd, C. E.; Hofmann, H. A.] Univ Texas Austin, Sect Integrat Biol, Austin, TX 78712 USA. [Huffman, L. S.; Hofmann, H. A.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Whitaker, K. W.; Hofmann, H. A.] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA. [Whitaker, K. W.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Neumeister, H.; Preuss, T.] CUNY Hunter Coll, Dept Psychol, New York, NY 10021 USA. RP Hofmann, HA (reprint author), Univ Texas Austin, Sect Integrat Biol, 1 Univ Stn,C0930, Austin, TX 78712 USA. EM hans@mail.utexas.edu OI Hofmann, Hans/0000-0002-3335-330X FU Department of Defense; National Science Foundation (NSF)-IOS [0946637, 0751311]; Hunter College of CUNY; Research Foundation of CUNY; Alfred P. Sloan Foundation; Institute for Cellular and Molecular Biology at the University of Texas at Austin FX This work was supported by the Department of Defense SMART program (K. W. Whitaker); National Science Foundation (NSF)-IOS Grant 0946637, Hunter College of CUNY, and Research Foundation of CUNY (T. Preuss); and NSF-IOS Grant 0751311, the Alfred P. Sloan Foundation, and the Institute for Cellular and Molecular Biology at the University of Texas at Austin (H. A. Hofmann). NR 94 TC 18 Z9 18 U1 0 U2 16 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD JUL PY 2011 VL 106 IS 1 BP 127 EP 137 DI 10.1152/jn.01126.2010 PG 11 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 786PC UT WOS:000292319400014 PM 21451063 ER PT J AU Ecker, RD Mulligan, LP Dirks, M Bell, RS Severson, MA Howard, RS Armonda, RA AF Ecker, Robert D. Mulligan, Lisa P. Dirks, Michael Bell, Randy S. Severson, Meryl A. Howard, Robin S. Armonda, Rocco A. TI Outcomes of 33 patients from the wars in Iraq and Afghanistan undergoing bilateral or bicompartmental craniectomy Clinical article SO JOURNAL OF NEUROSURGERY LA English DT Article DE craniectomy; penetrating head injury; traumatic brain injury ID MIDDLE CEREBRAL-ARTERY; DECOMPRESSIVE SURGERY; MALIGNANT INFARCTION; HEMICRANIECTOMY; EDEMA AB Object. There are no published long-term data for patients with penetrating head injury treated with bilateral supratentorial craniectomy, or supra- and infratentorial craniectomy. The authors report their experience with 33 patients treated with bilateral or bicompartmental craniectomy from the ongoing conflicts in Iraq and Afghanistan. Methods. An exploratory analysis of Glasgow Outcome Scale (GOS) scores at 6 months in 33 patients was performed. Follow-up lasting a median of more than 2 years was performed in 30 (91%) of these patients. The association of GOS score with categorical variables was explored using the Wilcoxon rank-sum test or Kruskal-Wallis analysis of variance. The Spearman correlation coefficient was used for ordinal/continuous data. To provide a clinically meaningful format to present GOS scores with categorical variables, patients with GOS scores of 1-3 were categorized as having a poor outcome and those with scores of 4 and 5 as having a good outcome. This analysis does not include the patients who died in theater or in Germany who underwent bilateral decompressive craniectomy because those figures have not been released due to security concerns. Results. All patients were men with a median age of 24 years (range 19-46 years) and a median initial Glasgow Coma Scale (GCS) score of 5 (range 3-14). At 6 months, 9 characteristics were statistically significant: focus of the initial injury, systemic infection, initial GCS score, initial GCS score excluding patients with a GCS score of 3, GCS score on arrival to the US. GCS score on dismissal from the medical center, Injury Severity Score, and patients with cerebrovascular injury. Six factors were significant at long-term follow-up: focus of initial injury, systemic infection, initial GCS score excluding patients with a GCS score of 3, GCS score on arrival to the US, and GCS score on dismissal from the medical center. At long-term follow-up, 7 (23%) of 30 patients had died, 5 (17%) of 30 had a GOS score of 2 or 3, and 18 (60%) of 30 had a GOS score of 4 or 5. Conclusions. In this selected group of patients who underwent bilateral or bicompartmental craniectomy, 60% are independent at long-term follow-up. Patients with bifrontal injury fared best. Systemic infection and cerebrovascular injury corresponded with a worse outcome. (DOI: 10.3171/2011.2.JNS101490) C1 [Ecker, Robert D.] Maine Med Partners Neurosurg & Spine, Scarborough, ME 04074 USA. [Mulligan, Lisa P.; Bell, Randy S.; Severson, Meryl A.; Armonda, Rocco A.] Natl Naval Med Ctr, Dept Neurosurg, Bethesda, MD USA. [Dirks, Michael] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Ecker, RD (reprint author), Maine Med Partners Neurosurg & Spine, 49 Spring St, Scarborough, ME 04074 USA. EM robertecker@me.com NR 10 TC 11 Z9 11 U1 1 U2 2 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JUL PY 2011 VL 115 IS 1 BP 124 EP 129 DI 10.3171/2011.2.JNS101490 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 782JO UT WOS:000292004700026 PM 21438659 ER PT J AU Cardoso, MJ Mendelsohn, A Rosner, MK AF Cardoso, Mario J. Mendelsohn, Audra Rosner, Michael K. TI Cervical hybrid arthroplasty with 2 unique fusion techniques SO JOURNAL OF NEUROSURGERY-SPINE LA English DT Article DE cervical arthroplasty; hybrid construct; Prestige ST; Prevail; Mystique ID ARTIFICIAL DISC REPLACEMENT; LEVEL INTRADISCAL PRESSURE; TERM-FOLLOW-UP; ADJACENT-LEVEL; CLINICAL-TRIAL; DISKECTOMY; ARTHRODESIS; RATES; SPINE; DECOMPRESSION AB Object. Multilevel cervical arthroplasty achieved using the Prestige ST disc can be challenging and often unworkable. An alternative to this system is a hybrid technique composed of alternating total disc replacements (TDRs) and fusions. In the present study, the authors review the safety and radiological outcomes of cervical hybrid arthroplasty in which the Prestige ST disc is used in conjunction with 2 unique fusion techniques. Methods. After obtaining institutional review board approval, the authors completed a retrospective review of all hybrid cervical constructs in which the Prestige ST disc was used between August 2007 and November 2009 at the Walter Reed Army Medical Center. A Prestige ST total disc replacement was performed in 119 patients. Thirty-one patients received a hybrid construct defined as a TDR and fusion (TDR anterior cervical decompression and fusion [ACDF]) or as 2 TDRs separated by a fusion (TDR-ACDF-TDR). A resorbable plate and graft system (Mystique) or stand-alone interbody spacer (Prevail) was implanted at the fusion levels. Plain radiographs were compared and evaluated for cervical lordosis, range of motion, implant complications, development of adjacent-level disease, and pseudarthrosis. In addition, charts were reviewed for clinical complications related to the index surgery. Results. Thirty-one patients (18 men and 13 women; mean age 50 years. range 32-74 years) received a hybrid construct. All patients were diagnosed with radiculopathy and/or myelopathy. Twenty-four patients received a 2-level and 7 a 3-level hybrid construct. In 2 patients in whom a 2-level hybrid construct was implanted, a noncontiguous TDR was also performed. The mean clinical and radiological follow-up duration was 18 months. There was no significant difference in preoperative (19.3 degrees +/- 13.3 degrees) and postoperative (19.7 degrees +/- 10.5 degrees) cervical lordosis (p = 0.48), but there was a significant decrease in range in motion (from 50.0 degrees +/- 11.8 degrees to 38.9 12.7) (p = 0.003). There were no instances of screw backout, implant dislodgement, progressive kyphosis, formation of heterotopic bone, pseudarthrosis, or symptomatic adjacent-level disease. Seven patients had dysphasia and 1 patient had vocal cord paralysis at 6 weeks. By 3 months, both the dysphasia and the vocal cord paralysis were resolved in all patients. Conclusions. Hybrid cervical arthroplasty involving the placement of a Prestige ST disc and either the Mystique resorbable plate or Prevail stand-alone interbody device is a safe and effective alternative to multilevel fusion for the management of cervical radiculopathy and myelopathy. (DOI: 10.3171/2011.3.SPINE10385) C1 [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. [Mendelsohn, Audra] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cardoso, MJ (reprint author), Walter Reed Army Med Ctr, Neurosurg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM mtcardoso@comcast.net NR 25 TC 18 Z9 26 U1 0 U2 11 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1547-5654 J9 J NEUROSURG-SPINE JI J. Neurosurg.-Spine PD JUL PY 2011 VL 15 IS 1 BP 48 EP 54 DI 10.3171/2011.3.SPINE10385 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 782JP UT WOS:000292004900012 PM 21456894 ER PT J AU Hoppes, CW Bahr, RJ Potter, BK AF Hoppes, Carrie W. Bahr, Robert J. Potter, Benjamin K. TI Coronoid Process Fracture SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Hoppes, Carrie W.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Bahr, Robert J.; Potter, Benjamin K.] Walter Reed Army Med Ctr, Washington, DC USA. RP Hoppes, CW (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2011 VL 41 IS 7 BP 532 EP 532 DI 10.2519/jospt.2011.0414 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 784QC UT WOS:000292172300010 PM 21725193 ER PT J AU Martini, WZ Cortez, D Colvin, S Sondeen, J Dubick, M Blackbourne, L AF Martini, W. Z. Cortez, D. Colvin, S. Sondeen, J. Dubick, M. Blackbourne, L. TI LR and Hextend resuscitation on coagulation following tissue injury and severe hemorrhage in pigs SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 [Martini, W. Z.; Cortez, D.; Colvin, S.; Sondeen, J.; Dubick, M.; Blackbourne, L.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JUL PY 2011 VL 9 SU 2 SI SI MA P-TU-538 BP 478 EP 478 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA V33AX UT WOS:000208992801319 ER PT J AU Dubick, MA Scherer, MS Schwacha, MG AF Dubick, M. A. Scherer, M. S. Schwacha, M. G. TI In vitro effects of resuscitation fluids on coagulation and markers of inflammation in human blood SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 [Dubick, M. A.; Scherer, M. S.] US Army Inst Surg Res, San Antonio, TX USA. [Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JUL PY 2011 VL 9 SU 2 SI SI MA P-TH-549 BP 939 EP 940 PG 2 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA V33AX UT WOS:000208992804322 ER PT J AU Henemyre-Harris, CL Sakuda, LS AF Henemyre-Harris, Claudia L. Sakuda, Linda S. TI Communicating Change to Laboratory Customers SO LABMEDICINE LA English DT Article DE laboratory change; communication; renovation; customer; phlebotomy AB The fast-paced world of the clinical laboratory encourages laboratory managers to evaluate and implement technological, process, and workspace changes in an effort to improve testing quality, turnaround time, and customer satisfaction. Managers must remember that even the simplest laboratory change may have a ripple effect throughout the entire hospital and/or medical system. This article describes a 7-step approach to assist laboratory managers in disseminating laboratory change to the appropriate customer at the right time. The approach includes the following steps: 1) identify the laboratory change; 2) target your audience; 3) build a communication team; 4) develop a communication plan; 5) implement the communication plan; 6) evaluate the communication plan; and 7) modify and execute the revised communication plan. A real-world application of the 7-step approach is described using the relocation of the phlebotomy lab for renovation as an example C1 [Henemyre-Harris, Claudia L.] Tripler Army Med Ctr, Core Lab, Tripler, HI USA. [Sakuda, Linda S.] Tripler Army Med Ctr, Pathol Support Serv, Dept Pathol, Tripler, HI USA. [Sakuda, Linda S.] Tripler Army Med Ctr, Area Lab Serv, Tripler, HI USA. RP Henemyre-Harris, CL (reprint author), Tripler Army Med Ctr, Core Lab, Tripler, HI USA. EM claudia.henemyre@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 J9 LABMEDICINE JI Labmedicine PD JUL PY 2011 VL 42 IS 7 BP 403 EP 409 DI 10.1309/LM0AO1W2SWBF10LW PG 7 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 783ZU UT WOS:000292124200003 ER PT J AU Mahoney, CR Brunye, TT Giles, G Lieberman, HR Taylor, HA AF Mahoney, Caroline R. Brunye, Tad T. Giles, Grace Lieberman, Harris R. Taylor, Holly A. TI Caffeine-induced physiological arousal accentuates global processing biases SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Caffeine; Arousal; Visual attention ID COGNITIVE PERFORMANCE; PSYCHOMOTOR PERFORMANCE; SALIVARY CORTISOL; VISUAL-ATTENTION; BIG PICTURE; MOOD; VIGILANCE; MEMORY; STRESS; FORM AB The effects of caffeine-induced arousal on global versus local object focus were investigated in non-habitual consumers using a double-blind, within-subjects, repeated-measures design. Following an overnight fast, low caffeine consumers (N = 36; M = 42.5 mg/day caffeine) completed 5 counterbalanced test sessions (normal consumption, 0 mg, 100 mg, 200 mg, and 400 mg) separated by at least 3 days. During each session, volunteers either consumed their normal amount of caffeine or were administered 1 of 4 treatment pills. One hour later they completed two tasks assessing visual attention, in counterbalanced order. Measures of mood, salivary caffeine and cortisol were taken at multiple time points. Dose-dependent elevation of caffeine in the saliva demonstrated the experimental manipulation was effective. Furthermore, analyses of the mood and arousal measures detected consistent changes on arousal subscales and caffeine administration elevated saliva cortisol. Analyses of the visual attention tasks revealed that caffeine-induced physiological arousal produced global processing biases, after as little as 100 mg caffeine. These data suggest caffeine consumption may influence how individuals attend to and process information in their environment and could influence daily tasks such as face recognition, learning new environments and navigation, especially for those who normally consume little caffeine. Published by Elsevier Inc. C1 [Mahoney, Caroline R.; Brunye, Tad T.; Giles, Grace; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Mahoney, Caroline R.] USA, NSRDEC, Attn AMSRD NSC WS CRCS, Natick, MA 01760 USA. [Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Mahoney, CR (reprint author), USA, NSRDEC, Attn AMSRD NSC WS CRCS, Kansas St, Natick, MA 01760 USA. EM Caroline.mahoney@us.army.mil NR 81 TC 7 Z9 8 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUL PY 2011 VL 99 IS 1 BP 59 EP 65 DI 10.1016/j.pbb.2011.03.024 PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 781DD UT WOS:000291909900009 PM 21463650 ER PT J AU Rankin, SJ Levy, SM Warren, JJ Gilmore, JE Broffitt, B AF Rankin, Scott J. Levy, Steven M. Warren, John J. Gilmore, Julie E. Broffitt, Barbara TI Relative validity of an FFQ for assessing dietary fluoride intakes of infants and young children living in Iowa SO PUBLIC HEALTH NUTRITION LA English DT Article DE Relative; Validation; Dietary; Fluoride ID FREQUENCY QUESTIONNAIRE; FOOD; VALIDATION; PATTERNS; DRINKS AB Objective: To determine the relative validity of a quantitative FFQ in assessing dietary fluoride intakes using 3 d food and beverage diaries for reference. Design: Parents were asked to complete questionnaires for the preceding week and diaries for 3 d for their children. Fluoride intakes were estimated from 'selected' foods and beverages for questionnaires and from 'all foods and beverages' for diaries. Data collected at 6, 9, 12, 16, 20, 24, 36, 48 and 60 months were analysed cross-sectionally. Setting: A 3 d food and beverage diary and an FFQ collected through mail from children living in the state of Iowa. Subjects: Children from the Iowa Fluoride Study whose parents completed both an FFQ and a 3 d food and beverage diary at each analysed time point. Results: Correlations between daily mean dietary fluoride intake estimated from questionnaires and diaries range from 0.90 to 0.65. Conclusions: A quantitative FFQ can provide relative estimates of dietary fluoride intake. C1 [Rankin, Scott J.] USA, MCDS, Ft Sam Houston, TX 78249 USA. [Levy, Steven M.; Warren, John J.; Broffitt, Barbara] Univ Iowa, Coll Dent, Dept Prevent & Community Dent, Iowa City, IA 52242 USA. [Gilmore, Julie E.] Univ Iowa, Inst Clin & Translat Sci, Iowa City, IA 52242 USA. RP Rankin, SJ (reprint author), USA, MCDS, 2050 Worth RD, Ft Sam Houston, TX 78249 USA. EM Scott.rankin@us.army.mil FU NIH [R01-DE09551, R01-DE12101, M01-RR00059] FX The present study was supported in part by NIH Grants R01-DE09551, R01-DE12101 and M01-RR00059. The present paper is an original work. The authors have no conflict of interest to declare. S.J.R was the lead author of the paper; S.M.L., J.J.W. and J.E.G. provided content and editorial contribution; B.B. provided statistical and data quality assistance. NR 17 TC 3 Z9 3 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1368-9800 J9 PUBLIC HEALTH NUTR JI Public Health Nutr. PD JUL PY 2011 VL 14 IS 7 BP 1229 EP 1236 DI 10.1017/S1368980011000474 PG 8 WC Public, Environmental & Occupational Health; Nutrition & Dietetics SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA 785ER UT WOS:000292210700013 PM 21450138 ER PT J AU Pickett, CA Jackson, JL Hemann, BA Atwood, JE AF Pickett, Christopher A. Jackson, Jeffrey L. Hemann, Brian A. Atwood, J. Edwin TI Carotid Artery Examination, An Important Tool in Patient Evaluation SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE carotid artery; physical examination; primary care ID VALVULAR AORTIC-STENOSIS; CEREBROVASCULAR INSUFFICIENCY; DOPPLER ECHOCARDIOGRAPHY; PHYSICAL-EXAMINATION; DISEASE; BRUITS; PULSE; PREVALENCE; DIAGNOSIS; METAANALYSIS AB Examination of the arteries is an age old medical tradition. Examination of the carotid artery is of unique importance because it is an easily accessible large artery. Through the methods of inspection, palpation, and auscultation, carotid artery examination gives clinicians important diagnostic clues about the health and disease of the patient. Inspection and palpation of the carotid give insight into left ventricular systolic function and distinguish types of valvular heart disease. Auscultation identifies patients with high-risk atherosclerosis. In most cases carotid examination is neither sensitive nor specific, but in the correct clinical context it offers important evidence leading to specific diagnoses and treatment. In this review, we discuss the examination of the carotid artery under normal conditions and describe how abnormalities in the carotid artery examination are indicators of disease. C1 [Pickett, Christopher A.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. Zablocki VA Med Ctr, Div Gen Med, Milwaukee, WI USA. Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. RP Pickett, CA (reprint author), US Mil Acad, Keller Army Hosp, Bldg 900, West Point, NY 10996 USA. EM christopher.pickett1@us.army.mil NR 56 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD JUL PY 2011 VL 104 IS 7 BP 526 EP 532 DI 10.1097/SMJ.0b013e31821e9493 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 780PV UT WOS:000291871700013 PM 21886054 ER PT J AU Brown, KV Li, B Guda, T Perrien, DS Guelcher, SA Wenke, JC AF Brown, Kate V. Li, Bing Guda, Teja Perrien, Daniel S. Guelcher, Scott A. Wenke, Joseph C. TI Improving Bone Formation in a Rat Femur Segmental Defect by Controlling Bone Morphogenetic Protein-2 Release SO TISSUE ENGINEERING PART A LA English DT Article ID BIODEGRADABLE POLYURETHANE SCAFFOLDS; OPEN TIBIAL FRACTURES; IN-VITRO DEGRADATION; GROWTH-FACTOR; SUSTAINED-RELEASE; DELIVERY; REGENERATION; MODEL; BMP-2; RHBMP-2 AB Nonunion is a common complication in open fractures and other severe bone injuries. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a collagen sponge enhances healing of fractures. However, the burst release of rhBMP-2 necessitates supra-physiological doses of rhBMP-2 to achieve a robust osteogenic effect, which introduces risk of ectopic bone formation and severe inflammation and increases the cost. Although the concept that the ideal pharmacokinetics for rhBMP-2 includes both a burst and sustained release is generally accepted, investigations into the effects of the release kinetics on new bone formation are limited. In the present study, biodegradable polyurethane (PUR) and PUR/microsphere [PUR/poly(lactic-co-glycolic acid)] composite scaffolds with varying rhBMP-2 release kinetics were compared to the collagen sponge delivery system in a critical-sized rat segmental defect model. Microcomputed tomography analysis indicated that a burst followed by a sustained release of rhBMP-2 from the PUR scaffolds regenerated 50% more new bone than the collagen sponge loaded with rhBMP-2, whereas a sustained release without the burst did not form significantly more bone than the scaffold without rhBMP-2. This study demonstrated that the putative optimal release profile (i.e., burst followed by sustained release) for rhBMP-2 can be achieved using PUR scaffolds, and that this enhanced pharmacokinetics regenerated more bone than the clinically available standard of care in a critical-sized defect in rat femora. C1 [Li, Bing; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Brown, Kate V.; Guda, Teja; Wenke, Joseph C.] USA, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, San Antonio, TX USA. [Guda, Teja] Wake Forest Inst Regenerat Med, Winston Salem, NC USA. [Perrien, Daniel S.] Vanderbilt Univ, Dept Orthopaed & Rehabil, Nashville, TN 37235 USA. [Perrien, Daniel S.] Vanderbilt Univ, Ctr Bone Biol, Nashville, TN 37235 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 2301 Vanderbilt Pl,VU Stn B 351604, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu; joseph.wenke@us.army.mil RI Guda, Teja/A-7286-2009 OI Guda, Teja/0000-0002-3218-2916 FU Department of Defense [W81XWH-07-1-0211] FX This study was funded in part by a Department of Defense Grant (Orthopaedic Extremity Trauma Research Program #W81XWH-07-1-0211). NR 50 TC 71 Z9 72 U1 3 U2 26 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD JUL PY 2011 VL 17 IS 13-14 BP 1735 EP 1746 DI 10.1089/ten.tea.2010.0446 PG 12 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 782PT UT WOS:000292022300008 PM 21338268 ER PT J AU Parker, PM Rice, KR Sterbis, JR Chen, YM Cullen, J McLeod, DG Brassell, SA AF Parker, Patrick M. Rice, Kevin R. Sterbis, Joseph R. Chen, Yongmei Cullen, Jennifer McLeod, David G. Brassell, Stephen A. TI Prostate Cancer in Men Less Than the Age of 50: A Comparison of Race and Outcomes SO UROLOGY LA English DT Article ID RADICAL PROSTATECTOMY; DISEASE RESEARCH; YOUNGER; ADENOCARCINOMA; ANTIGEN; STAGE AB OBJECTIVE To compare clinicopathologic features and survival outcomes for men 50 years of age in relation to other age groups stratified by race to further define prostate cancer (CaP) in young men. Controversy exists regarding the appropriate age to undergo CaP screening, outcomes for early intervention, and whether there is unique age-associated tumor biology. We compared clinicopathologic features and survival outcomes for men <50 years of age in relation to other age groups stratified by race to further define CaP in young men. METHODS was conducted. Patients were stratified by age group, race, and decade of treatment. Demographic and clinicopathologic characteristics were compared across age groups using chi-square tests and analysis of variance. The primary study endpoints, time to biochemical recurrence and all-cause mortality, were compared across age groups using Kaplan-Meier estimation and univariable and multivariable Cox proportional hazards analysis. RESULTS Only 4.5% of the study sample was <50 years of age. A higher percentage of African Americans diagnosed were <50 compared with Caucasians (8.3% vs 3.3%, P < .0001). Positive family history was more prevalent in the <50 cohort (36.1% vs 22.0%, P < .0001). Despite these findings, both racial subgroups for men <50 years of age demonstrated improved clinicpathologic features than other age quartiles. Furthermore, both Kaplan-Meier and Cox proportional hazard analysis demonstrated that the <50 cohort had a lower incidence of biochemical recurrence and greater overall survival. CONCLUSIONS Race and family history appear to play a significant role in the incidence of CaP in younger men. Younger age at diagnosis is associated with more favorable outcomes and indicates that population-based screening at younger ages could potentially lead to improved survival for high-risk groups. UROLOGY 78: 110-115, 2011. Published by Elsevier Inc. C1 [Brassell, Stephen A.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Ward 56, Urol Serv,Dept Surg, Washington, DC 20307 USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Ward 56, Urol Serv,Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Stephen.Brassell@amedd.army.mil NR 22 TC 20 Z9 22 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JUL PY 2011 VL 78 IS 1 BP 110 EP 115 DI 10.1016/j.urology.2010.12.046 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 783KE UT WOS:000292080300029 PM 21397300 ER PT J AU Cross, JD Johnson, AE Wenke, JC Bosse, MJ Ficke, JR AF Cross, Jessica D. Johnson, Anthony E. Wenke, Joseph C. Bosse, Michael J. Ficke, James R. TI Mortality in Female War Veterans of Operations Enduring Freedom and Iraqi Freedom SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID COMBAT CASUALTY CARE; INJURIES; TRAUMA; AGE AB Combat-wounded service members are surviving battle injuries more than ever. Given different combat roles held by men and women, female service members should survive wounds at an unprecedented rate. We determined whether the casualty rates for females differ from their male counterparts and characterized wounds sustained by female casualties. We calculated the percentage of the 5141 deaths among the 40,531 casualties by gender for those serving in Operations Enduring Freedom (OEF) and Iraqi Freedom (OIF) from Defense Manpower Statistics between 2001 and 2009. We searched the Joint Theatre Trauma Registry for female casualties and described their injury characteristics. No matched cohort of male casualties was searched. Female veterans comprised 1.9% of all casualties and 2.4% of all deaths. In OIF, the percent death for women was 14.5% (103 deaths) versus 12.0% (4226 deaths) for men. In OEF, the percent death for women was 35.9% (19 deaths) versus 17.0% (793 deaths) for men. Battle-injured females had a greater proportion of facial and external injuries and more severe extremity injuries compared with those nonbattle-injured. The casualty death rate appears higher for women than men although the mechanisms of fatal injuries are not known and may not be comparable. Although facial, external, and extremity injuries were common among battle-injured females, no conclusion can be made as to whether male casualties sustain similar wounding patterns. Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. C1 [Cross, Jessica D.; Johnson, Anthony E.; Ficke, James R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78244 USA. [Cross, Jessica D.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bosse, Michael J.] Carolinas Med Ctr, Charlotte, NC 28203 USA. RP Cross, JD (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78244 USA. EM jessica.cross@us.army.mil OI Johnson, Anthony/0000-0002-0506-0059 NR 18 TC 6 Z9 6 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUL PY 2011 VL 469 IS 7 BP 1956 EP 1961 DI 10.1007/s11999-011-1840-z PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 775SW UT WOS:000291484700025 PM 21390560 ER PT J AU Boesl, BP Bourne, GR Sankar, BV AF Boesl, Benjamin P. Bourne, Gerald R. Sankar, Bhavani V. TI Insitu multiscale analysis of fracture mechanisms in nanocomposites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Particle reinforcement; Fracture toughness; FEA; Insitu testing ID CARBON NANOTUBES; POLYMER NANOCOMPOSITES; COMPOSITES; REINFORCEMENT; TOUGHNESS AB Toughening mechanisms in hard, metal oxide nanoparticle reinforced epoxy systems were analyzed using a multi-scale approach. Samples on varying scales were fabricated using a shear mixing device and the dispersion of the particles was characterized. On the macro-scale, four-point bend testing showed a maximum of an 80% increase in fracture toughness over neat resin samples for composites with low filler volume percents. Novel testing completed within the chamber of a focused ion beam provided insight into the mechanisms of fracture on the microscale, providing validation of the existence of micro-cracking and crack pinning in the material. Further analysis of the results was coupled with finite element analysis to determine the feasibility of proposed fracture mechanisms, providing insight for the direction of future analysis. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Boesl, Benjamin P.] USA, Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Bourne, Gerald R.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Sankar, Bhavani V.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. RP Boesl, BP (reprint author), USA, Res Lab, RDRL WMM B, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM ben.boesl@us.army.mil RI Bourne, Gerald/B-7219-2008; Boesl, Benjamin/B-7334-2009; OI Bourne, Gerald/0000-0001-6977-2138; Boesl, Benjamin/0000-0001-9265-4762; Sankar, Bhavani/0000-0002-4556-1982 FU Newton C. Ebaugh Professorship fund; Florida Space Grants Consortium FX This research was supported by Newton C. Ebaugh Professorship fund. Partial funding was provided by the Florida Space Grants Consortium., and the authors are thankful to Dr. Jayadeep Mukherjee, Director of FSGC, for his support and encouragement. The authors would also like to thank Dr. W.G. Sawyer of the University of Florida for many helpful discussions regarding particle dispersion techniques. NR 22 TC 6 Z9 6 U1 1 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD JUL PY 2011 VL 42 IS 5 BP 1157 EP 1163 DI 10.1016/j.compositesb.2011.03.009 PG 7 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 776BJ UT WOS:000291509200019 ER PT J AU Abouchacra, KS Besing, J Koehnke, J Letowski, T AF Abouchacra, Kim S. Besing, Joan Koehnke, Janet Letowski, Tomasz TI The effects of reverberation on a listener's ability to recognize target sentences in the presence of up to three synchronized masking sentences SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Speech recognition; Cocktail party effect; Reverberation ID SPATIAL SEPARATION; ENERGETIC MASKING; SPEECH-INTELLIGIBILITY; INFORMATIONAL MASKING; SIMULTANEOUS TALKERS; SELECTIVE ATTENTION; NORMAL-HEARING; PERCEPTION; NOISE; IDENTIFICATION AB Objective: To determine the effects of room reverberation on target sentence recognition in the presence of 0-to-3 synchronous masking sentences. Design : Target and masker sentences were presented through four loudspeakers (+/- 90 degrees and +/- 45 degrees azimuth; 1m from the listener) in rooms having reverberation times (RT) of 0.2, 0.4, 0.6, and 1.1 s. Study Sample : Four groups of 13 listeners each participated in the study (N = 52). Results : In rooms with RTs of 0.2, 0.4, and 0.6 s, mean speech recognition scores (SRSs) were similar, with scores ranging from 96-100%, 90-95%, 75-80%, and 53-60%, when 0, 1, 2, and 3 competing sentences were present, respectively. However, in the room with a RT = 1.1 s, SRSs deteriorated significantly faster as the number of competing sentences increased; mean scores were 93%, 73%, 26%, and 10%, in the 0, 1, 2, 3, competing sentence condition, respectively. The majority of errors in SRSs (98%) resulted from listeners reporting words presented in masking sentences along with those in target sentences (mixing errors). Conclusions : Results indicate that reverberation has a similar influence on SRSs measured in multi-talker environments, when room reverberation is <= 0.6 s. However, SRSs are dramatically reduced in the room with a RT = 1.1 s, even when only one competing talker is present. C1 [Abouchacra, Kim S.] Amer Univ Beirut, Med Ctr, Dept Otolaryngol Head & Neck Surg, Beirut, Lebanon. [Besing, Joan; Koehnke, Janet] Montclair State Univ, Dept Commun Sci & Disorders, Montclair, NJ USA. [Letowski, Tomasz] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Abouchacra, KS (reprint author), Amer Univ Beirut, Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 11-0236, Beirut, Lebanon. EM ks05@aub.edu.lb FU U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland, USA FX The authors would like to thank Mr. Tuyen Tran for designing the initial version of the custom software used in conjunction with the S 3 corpus. This work was supported by the U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland, USA. NR 41 TC 0 Z9 0 U1 1 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD JUL PY 2011 VL 50 IS 7 BP 468 EP 476 DI 10.3109/14992027.2011.565424 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 776RB UT WOS:000291553800005 PM 21668326 ER PT J AU Ter-Gabrielyan, N Fromzel, V Lukasiewicz, T Ryba-Romanowski, W Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Lukasiewicz, T. Ryba-Romanowski, W. Dubinskii, M. TI High power resonantly diode-pumped sigma-configuration Er3+:YVO4 laser at 1593.5 nm SO LASER PHYSICS LETTERS LA English DT Article DE laser; diode-pumped laser; solid-state laser; erbium doped laser ID SOLID-STATE LASERS; CERAMIC LASER; MU-M; YVO4 CRYSTALS; TEMPERATURE; LEVEL; ER3+ AB Laser operation of an eyesafe 1593.5-nm laser based on Er3+-doped yttrium orthovanadate single crystal resonantly-pumped by a spectrally-narrowed InGaAsP/InP diode bar stack is demonstrated for the first time. Cryogenically-cooled Er3+:YVO4 laser pumped at 1534 nm performed with maximum slope efficiency of similar to 70% and maximum quasi-continuous-wave (Q-CW) power of 59.8 W. C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Lukasiewicz, T.] Inst Elect Mat Technol, PL-01919 Warsaw, Poland. [Ryba-Romanowski, W.] Polish Acad Sci, Inst Low Temp & Struct Res, PL-50422 Wroclaw, Poland. RP Dubinskii, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 25 TC 15 Z9 15 U1 0 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD JUL PY 2011 VL 8 IS 7 BP 529 EP 534 DI 10.1002/lapl.201110031 PG 6 WC Optics; Physics, Applied SC Optics; Physics GA 776TR UT WOS:000291561600007 ER PT J AU Huang, XZ Cash, DM Chahine, MA Van Horn, GT Erwin, DP Mckay, JT Hamilton, LR Jerke, KH Co, EMA Aldous, WK Lesho, EP Lindler, LE Bowden, RA Nikolich, MP AF Huang, X. -Z. Cash, D. M. Chahine, M. A. Van Horn, G. T. Erwin, D. P. McKay, J. T. Hamilton, L. R. Jerke, K. H. Co, E. -M. A. Aldous, W. K. Lesho, E. P. Lindler, L. E. Bowden, R. A. Nikolich, M. P. TI Methicillin-resistant Staphylococcus aureus infection in combat support hospitals in three regions of Iraq SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE CA-MRSA; infection; Iraq ID SOFT-TISSUE INFECTION; RISK-FACTORS; NASAL COLONIZATION; UNITED-STATES; SKIN INFECTIONS; COMMUNITY; PREVALENCE; CARRIAGE; SEX; MEN AB Staphylococcus aureus is a leading cause of infections in deployed service members. Based on a molecular epidemiological study of 182 MRSA isolates from patients in three U.S. Army combat support hospitals in separate regions in Iraq, USA300 clone was the most predominant (80%) pulsotype. This finding suggested that strain carriage from the home country by military personnel is epidemiologically more important than local acquisition. C1 [Huang, X. -Z.; Cash, D. M.; Chahine, M. A.; Lesho, E. P.; Bowden, R. A.; Nikolich, M. P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Van Horn, G. T.; Erwin, D. P.; McKay, J. T.; Hamilton, L. R.; Co, E. -M. A.; Aldous, W. K.] US CSHs, Baghdad, Iraq. [Jerke, K. H.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Lindler, L. E.] Sci & Technol Directorate, Chem & Biol Div, Dept Homeland Secur, Washington, DC USA. RP Huang, XZ (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xiaozhe.huang@amedd.army.mil RI Nikolich, Mikeljon/B-2868-2011 FU Division of HIV/AIDS Prevention and the Division of Healthcare Quality Promotion, CDC FX This publication was made possible by support from the Division of HIV/AIDS Prevention and the Division of Healthcare Quality Promotion, CDC. The findings and conclusions in this report are those of the authors and do not necessarily represent the official views of the CDC. NR 42 TC 4 Z9 4 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JUL PY 2011 VL 139 IS 7 BP 994 EP 1008 DI 10.1017/S0950268810001950 PG 15 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 770UY UT WOS:000291115200005 PM 20727246 ER PT J AU Satapathi, S Li, L Kumar, A Huo, HB Anandakathir, R Shen, MY Samuelson, LA Kumar, J AF Satapathi, Soumitra Li, Lian Kumar, Abhishek Huo, Haibin Anandakathir, Robinson Shen, Mengyan Samuelson, Lynne A. Kumar, Jayant TI Strong two-photon-induced fluorescence from a highly soluble polythiophene SO OPTICS COMMUNICATIONS LA English DT Article DE Two-photon-fluorescence; Polythiophene; Femto-second laser ID CROSS-SECTIONS; MICROSCOPY; EXCITATION; ABSORPTION; LASER; DESIGN; LIGHT AB Two-photon-induced fluorescence from a soluble polythiophene containing urethane side groups has been investigated using femto-second laser pulses at 800 nm. Strong two-photon fluorescence was measured in polymer solution. The quadratic dependence of the fluorescence on the excitation laser intensity confirmed the two-photon process. The measured two-photon absorption cross-section is larger as compared to those of other reported polythiophenes. This polymer can be readily hydrolyzed to yield a water soluble polythiophene which could be useful in biological imaging. (c) 2011 Elsevier B.V. All rights reserved. C1 [Satapathi, Soumitra; Kumar, Abhishek; Anandakathir, Robinson; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Satapathi, Soumitra; Kumar, Abhishek; Huo, Haibin; Shen, Mengyan; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. [Li, Lian; Samuelson, Lynne A.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu FU US Army Natick Soldier Research, Development and Engineering Center [DAAD16-01-C-0011]; NSF [ECS-0601602] FX Financial supports from the US Army Natick Soldier Research, Development and Engineering Center (DAAD16-01-C-0011) and NSF (ECS-0601602) are gratefully acknowledged. Part of the research was performed while L.L. held the Senior National Research Council Research Associateship at the US Army Natick Soldier Research, Development and Engineering Center. NR 21 TC 5 Z9 7 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUL 1 PY 2011 VL 284 IS 14 BP 3612 EP 3614 DI 10.1016/j.optcom.2011.03.048 PG 3 WC Optics SC Optics GA 771RV UT WOS:000291179300023 ER PT J AU Che, MM Chanda, S Song, J Doctor, BP Rezk, PE Sabnekar, P Perkins, MW Sciuto, AM Nambiar, MP AF Che, Magnus M. Chanda, Soma Song, Jian Doctor, Bhupendra P. Rezk, Peter E. Sabnekar, Praveena Perkins, Michael W. Sciuto, Alfred M. Nambiar, Madhusoodana P. TI Aerosolized scopolamine protects against microinstillation inhalation toxicity to sarin in guinea pigs SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Chemical warfare; cholinesterases; nasal therapeutic agents; inhalation exposure; respiratory toxicity ID NERVE AGENT-VX; INDUCED RESPIRATORY DEPRESSION; SOMAN-INDUCED SEIZURES; INDUCED LETHALITY; INTRANASAL SCOPOLAMINE; BRONCHOALVEOLAR LAVAGE; CHEMICAL WARFARE; MOTION SICKNESS; EXPOSURE; ATROPINE AB Sarin is a volatile nerve agent that has been used in the Tokyo subway attack. Inhalation is predicted to be the major route of exposure if sarin is used in war or terrorism. Currently available treatments are limited for effective postexposure protection against sarin under mass casualty scenario. Nasal drug delivery is a potential treatment option for mass casualty under field conditions. We evaluated the efficacy of endotracheal administration of muscarinic antagonist scopolamine, a secretion blocker which effectively crosses the blood-brain barrier for protection against sarin inhalation toxicity. Age and weight matched male Hartley guinea pigs were exposed to 677.4 mg/m(3) or 846.5 mg/m(3) (1.2 x LCt(50)) sarin by microinstillation inhalation exposure for 4 min. One minute later, the animals exposed to 846.5 mg/m(3) sarin were treated with endotracheally aerosolized scopolamine (0.25 mg/kg) and allowed to recover for 24 h for efficacy evaluation. The results showed that treatment with scopolamine increased the survival rate from 20% to 100% observed in untreated sarin-exposed animals. Behavioral symptoms of nerve agent toxicity including, convulsions and muscular tremors were reduced in sarin-exposed animals treated with scopolamine. Sarin-induced body weight loss, decreased blood O(2) saturation and pulse rate were returned to basal levels in scopolamine-treated animals. Increased bronchoalveolar lavage (BAL) cell death due to sarin exposure was returned to normal levels after treatment with scopolamine. Taken together, these data indicate that postexposure treatment with aerosolized scopolamine prevents respiratory toxicity and protects against lethal inhalation exposure to sarin in guinea pigs. C1 [Che, Magnus M.; Chanda, Soma; Song, Jian; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Closed Head Injury Branch, Silver Spring, MD 20910 USA. [Rezk, Peter E.; Sabnekar, Praveena; Perkins, Michael W.; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Closed Head Injury Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU National Institutes of Environmental Health Sciences/National Institutes of Health [5U01ES015677] FX The project described was supported by Grant Number 5U01ES015677 from the National Institutes of Environmental Health Sciences/National Institutes of Health and managed by the Geneva Foundation, Lakewood, WA. Its contents, opinions and assertions contained herein are private views of the authors and are not to be construed as official or reflecting the views of the National Institutes of Environmental Health Sciences/National Institutes of Health, Department of the Army or the Department of Defense. NR 62 TC 3 Z9 3 U1 0 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD JUL PY 2011 VL 21 IS 6 BP 463 EP 472 DI 10.3109/15376516.2011.562258 PG 10 WC Toxicology SC Toxicology GA 774ND UT WOS:000291392400004 PM 21651338 ER PT J AU Lospinoso, JA Schweinberger, M Snijders, TAB Ripley, RM AF Lospinoso, Joshua A. Schweinberger, Michael Snijders, Tom A. B. Ripley, Ruth M. TI Assessing and accounting for time heterogeneity in stochastic actor oriented models SO ADVANCES IN DATA ANALYSIS AND CLASSIFICATION LA English DT Article DE Stochastic actor oriented models; Longitudinal analysis of network data; Time heterogeneity; Score-type test ID MAXIMUM-LIKELIHOOD-ESTIMATION; SPECIFICATION ERROR; NETWORKS; SMOKING AB This paper explores time heterogeneity in stochastic actor oriented models (SAOM) proposed by Snijders (Sociological methodology. Blackwell, Boston, pp 361-395, 2001) which are meant to study the evolution of networks. SAOMs model social networks as directed graphs with nodes representing people, organizations, etc., and dichotomous relations representing underlying relationships of friendship, advice, etc. We illustrate several reasons why heterogeneity should be statistically tested and provide a fast, convenient method for assessment and model correction. SAOMs provide a flexible framework for network dynamics which allow a researcher to test selection, influence, behavioral, and structural properties in network data over time. We show how the forward-selecting, score type test proposed by Schweinberger (Chapter 4: Statistical modeling of network panel data: goodness of fit. PhD thesis, University of Groningen 2007) can be employed to quickly assess heterogeneity at almost no additional computational cost. One step estimates are used to assess the magnitude of the heterogeneity. Simulation studies are conducted to support the validity of this approach. The ASSIST dataset (Campbell et al. In Lancet 371(9624):1595-1602, 2008) is reanalyzed with the score type test, one step estimators, and a full estimation for illustration. These tools are implemented in the RSiena package, and a brief walkthrough is provided. C1 [Lospinoso, Joshua A.; Snijders, Tom A. B.; Ripley, Ruth M.] Univ Oxford, Dept Stat, Oxford OX1 3TG, England. [Lospinoso, Joshua A.] US Mil Acad, Network Sci Ctr, New York, NY USA. [Schweinberger, Michael] Penn State Univ, Dept Stat, University Pk, PA 16802 USA. [Snijders, Tom A. B.] Univ Groningen, Dept Sociol, Groningen, Netherlands. RP Lospinoso, JA (reprint author), Univ Oxford, Dept Stat, Oxford OX1 3TG, England. EM lospinos@stats.ox.ac.uk; michael.schweinberger@stat.psu.edu; snijders@stats.ox.ac.uk; ruth@stats.ox.ac.uk RI Snijders, Tom/F-2896-2012 OI Snijders, Tom/0000-0003-3157-4157 FU U.S. Army [611102B74F]; MIPR [9FDATXR048]; U.S. N.I.H. (National Institutes of Health) [1R01HD052887-01A2, 1R01GM083603-01] FX This research was funded in part by U.S. Army Project Number 611102B74F and MIPR Number 9FDATXR048 (JAL); by U.S. N.I.H. (National Institutes of Health) Grant Number 1R01HD052887-01A2, for the project Adolescent Peer Social Network Dynamics and Problem Behavior (TABS and RMR); and by U.S. N.I.H. (National Institutes of Health) Grant Number 1R01GM083603-01 (MS). NR 40 TC 19 Z9 19 U1 1 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1862-5347 EI 1862-5355 J9 ADV DATA ANAL CLASSI JI Adv. Data Anal. Classif. PD JUL PY 2011 VL 5 IS 2 BP 147 EP 176 DI 10.1007/s11634-010-0076-1 PG 30 WC Statistics & Probability SC Mathematics GA 768SJ UT WOS:000290958400006 PM 22003370 ER PT J AU Yakes, BJ DeGrasse, SL Poli, M Deeds, JR AF Yakes, Betsy Jean DeGrasse, Stacey L. Poli, Mark Deeds, Jonathan R. TI Antibody characterization and immunoassays for palytoxin using an SPR biosensor SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Palytoxin; Surface plasmon resonance; Biosensor; Antibody characterization; Immunoassay ID NEUTRALIZATION AB Palytoxin (PLTX), a polyether marine toxin originally isolated from the zoanthid Palythoa toxica, is one of the most toxic non-protein substances known. Fatal poisonings have been linked to ingestion of PLTX-contaminated seafood, and effects in humans have been associated with dermal and inhalational exposure to PLTX containing organisms and waters. Additionally, PLTX co-occurrence with other well-characterized seafood toxins (e.g., ciguatoxins, saxitoxins, tetrodotoxin) has hindered direct associations of PLTX to seafood-borne illnesses. There are currently no validated methods for the quantitative detection of PLTX(s). As such, a well-characterized, robust, specific analytical technique is needed for the detection of PLTX(s) in source organisms, surrounding waters, and clinical samples. Surface plasmon resonance (SPR) biosensors are ideally suited for antibody characterization and quantitative immunoassay detection. Herein, we describe a newly developed SPR assay for PLTX. An anti-mouse substrate was used to characterize the kinetic values for a previously developed monoclonal anti-PLTX. The characterized antibody was then incorporated into a sensitive, rapid, and selective PLTX assay. Buffer type, flow rate, analyte-binding time, and regeneration conditions were optimized for the antibody-PLTX system. Cross-reactivity to potentially co-occurring seafood toxins was also evaluated. We show that this optimized assay is capable of measuring low- to sub-ng/mL PLTX levels in buffer and two seafood matrices (grouper and clam). Preliminary results indicate that this SPR biosensor assay allows for (1) rapid characterization of antibodies and (2) rapid, sensitive PLTX concentration determination in seafood matrices. Method development information contained herein may be broadly applied to future PLTX detection and/or antibody characterization efforts. C1 [Yakes, Betsy Jean; DeGrasse, Stacey L.; Deeds, Jonathan R.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA. [Poli, Mark] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Yakes, BJ (reprint author), US FDA, Ctr Food Safety & Appl Nutr, 5100 Paint Branch Pkwy, College Pk, MD 20740 USA. EM betsy.yakes@fda.hhs.gov RI Yakes, Betsy/K-2646-2012; OI DeGrasse, Stacey/0000-0001-7808-4193 NR 17 TC 15 Z9 15 U1 2 U2 27 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUL PY 2011 VL 400 IS 9 BP 2865 EP 2869 DI 10.1007/s00216-011-5019-y PG 5 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 769SE UT WOS:000291037800019 PM 21523328 ER PT J AU Chen, Y Huang, W AF Chen, Yun Huang, Wei TI Non-impact, blast-induced mild TBI and PTSD: Concepts and caveats SO BRAIN INJURY LA English DT Review DE Mild traumatic brain injury; battlefield post-traumatic stress disorder; blast over-pressure wave; volumetric blood surge; cerebrovascular insults ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; OIF/OEF SERVICE MEMBERS; CLOSED-HEAD INJURY; EXPLOSIVE BLAST; AXONAL INJURY; MODEL; IRAQ; CARE; WAVE AB Primary objective: A volumetric blood surge (rapid physical movement/displacement of blood) is hypothesized to cause the non-impact, mild TBI and battlefield PTSD induced by a blast over-pressure wave. Research design: Systematic review of the literature. Methods and procedures: Articles relating to the fields of blast injury, brain injury and relevant disorders were searched between the years 1968-2010 for keywords such as 'brain injury', 'post-traumatic stress disorder' and 'blast pressure wave'. Articles found through journal and internet databases were cross-referenced. Main outcomes and results: The blood surge, which is driven by elevated overall pressure in the ventral body cavity after exposure of the torso to blast wave, may move through blood vessels to the low-pressure cranial cavity from the high-pressure ventral body cavity. It dramatically increases cerebral perfusion pressure and causes damage to both tiny cerebral blood vessels and the BBB. Conclusions: Three factors may be critical to the induction of blast-induced brain injuries: (1) the difference in pressure between the ventral body cavity and cranial cavity; (2) blood that acts as a transmission medium to propagate a pressure wave to the brain; and (3) the vulnerability of cerebral blood vessels and the BBB to a sudden fluctuation in perfusion pressure. C1 [Chen, Yun] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Huang, Wei] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chen, Y (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM yun.chen@us.army.mil NR 71 TC 38 Z9 40 U1 0 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD JUL PY 2011 VL 25 IS 7-8 BP 641 EP 650 DI 10.3109/02699052.2011.580313 PG 10 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 769RJ UT WOS:000291035600001 PM 21604927 ER PT J AU Anderson, WR Meagher, NE Vanderhoff, JA AF Anderson, William R. Meagher, Nancy E. Vanderhoff, John A. TI Dark zones of solid propellant flames: Critically assessed datasets, quantitative model comparison, and detailed chemical analysis SO COMBUSTION AND FLAME LA English DT Article DE Solid propellant combustion; Combustion chemistry; Dark zones ID GAS-PHASE; COMBUSTION; CHEMISTRY; TEMPERATURE; HNO; RDX; HMX AB The formation of propellant dark zone (DZ) structures in the gaseous flames above many solid propellants has been a subject of recurrent interest to us for about 20 years. The DZ structure is controlled by small molecule chemistry. The DZ chemistry is very important in controlling both the flame structure at low pressure (10-100 atm) and burning rates at high pressure (above similar to 500 atm), even though DZs collapse at higher pressures. We developed a detailed, frequently updated mechanism to model it. This report reviews prior work, introduces our most recent modeling results, and documents the first quantitative tests of several key assumptions. All relevant experimental literature is critically assessed to identify datasets for testing our model. Comparison of predictions and experimental results shows reasonable agreement, and thus we advocate use of our mechanism. But the precision of both experiments and predictions is not tight, nor are there many test datasets. Further experimentation is needed, and types of study that would be of greatest benefit are suggested. A detailed discussion of the chemistry that controls DZ structure is presented. Published by Elsevier Inc. on behalf of The Combustion Institute. C1 [Anderson, William R.] USA, RDRL WML D, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Anderson, WR (reprint author), USA, RDRL WML D, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM william.robert.anderson@us.army.mil NR 75 TC 7 Z9 7 U1 3 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD JUL PY 2011 VL 158 IS 7 BP 1228 EP 1244 DI 10.1016/j.combustflame.2011.01.010 PG 17 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 768KF UT WOS:000290932600002 ER PT J AU Arcidiacono, S Meehan, AM Kirby, R Soares, JW AF Arcidiacono, Steven Meehan, Alexa M. Kirby, Romy Soares, Jason W. TI Kinetic microplate assay for determining immobilized antimicrobial peptide activity SO ANALYTICAL BIOCHEMISTRY LA English DT Article AB Antimicrobial peptide immobilization onto surfaces is of great interest, although characterization of activity can be problematic. The kinetic microplate method described here determines the minimum bactericidal concentration (MBC) of immobilized antimicrobial peptides through a combination and modification of traditional solution assays, overcoming the difficulties of working with a solid substrate. The technique enables rapid, accurate evaluation of immobilized peptide lytic behavior, elucidating both dose- and time-dependent activity at multiple concentrations. Furthermore, the method yields information regarding sublethal concentrations not realized in the traditional assays. (c) 2011 Elsevier Inc. All rights reserved. C1 [Arcidiacono, Steven; Meehan, Alexa M.; Kirby, Romy; Soares, Jason W.] USA, Biol Sci & Technol Team, Warfighter Sci Technol & Appl Res Directorate, NSRDEC, Natick, MA 01760 USA. RP Arcidiacono, S (reprint author), USA, Biol Sci & Technol Team, Warfighter Sci Technol & Appl Res Directorate, NSRDEC, Natick, MA 01760 USA. EM steven.arcidiacono@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 1 PY 2011 VL 414 IS 1 BP 163 EP 165 DI 10.1016/j.ab.2011.03.011 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 765KK UT WOS:000290704300022 PM 21402048 ER PT J AU Rathbone, CR Cross, JD Brown, KV Murray, CK Wenke, JC AF Rathbone, Christopher R. Cross, Jessica D. Brown, Kate V. Murray, Clinton K. Wenke, Joseph C. TI Effect of Various Concentrations of Antibiotics on Osteogenic Cell Viability and Activity SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE osteoblasts; cell viability; osteogenic activity; local antibiotics ID BONE MORPHOGENETIC PROTEIN-2; SEGMENTAL DEFECT MODEL; OSTEOBLASTS IN-VITRO; POLYURETHANE SCAFFOLDS; MICROBIAL BIOFILMS; LOCAL-DELIVERY; GENTAMICIN; TOBRAMYCIN; AMINOGLYCOSIDES; TROVAFLOXACIN AB Infection is a common complication of open fractures. Systemic antibiotics often cause adverse events before eradication of infected bone occurs. The local delivery of antibiotics and the use of implants that deliver both growth factors and antimicrobials are ways to circumvent systemic toxicity while decreasing infection and to reach extremely high levels required to treat bacterial biofilms. When choosing an antibiotic for a local delivery system, one should consider the effect that the antibiotic has on cell viability and osteogenic activity. To address this concern, osteoblasts were treated with 21 different antibiotics over 8 concentrations from 0 to 5,000 mu g/ml. Osteoblast deoxyribonucleic acid content and alkaline phosphatase activity (ALP) were measured to determine cell number and osteogenic activity, respectively. Antibiotics that caused the greatest decrement include rifampin, minocycline, doxycycline, nafcillin, penicillin, ciprofloxacin, colistin methanesulfonate, and gentamicin; their cell number and ALP were significantly less than control at drug concentrations <= 200 mu g/ml. Conversely, amikacin, tobramycin, and vancomycin were the least cytotoxic and did not appreciably affect cell number and ALP until very high concentrations were used. This comprehensive evaluation of numerous antibiotics' effects on osteoblast viability and activity will enable clinicians and researchers to choose the optimal antibiotic for treatment of infection and maintenance of healthy host bone. (C) 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 1070-1074, 2011 C1 [Rathbone, Christopher R.; Cross, Jessica D.; Brown, Kate V.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Rathbone, CR (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers, Ft Sam Houston, TX 78234 USA. EM chris.rathbone@us.army.mil FU intramural federal funding FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or US Government. The authors are employees of the US government. This project was supported by intramural federal funding. NR 32 TC 78 Z9 83 U1 2 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD JUL PY 2011 VL 29 IS 7 BP 1070 EP 1074 DI 10.1002/jor.21343 PG 5 WC Orthopedics SC Orthopedics GA 764MF UT WOS:000290632900016 PM 21567453 ER PT J AU Majumdar, S Ford, BM Mar, KD Sullivan, VJ Ulrich, RG D'Souza, AJM AF Majumdar, Sumit Ford, Brandi M. Mar, Kevin D. Sullivan, Vince J. Ulrich, Robert G. D'Souza, Ajit Joseph M. TI Evaluation of the Effect of Syringe Surfaces on Protein Formulations SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article DE biotechnology; protein aggregation; protein formulation; physical stability; materials science ID MONOCLONAL-ANTIBODY; INDUCED AGGREGATION; SILICONE OIL; QUANTITATION; PERSPECTIVE; PARTICLES; QUALITY AB Packaging of drugs in prefillable syringes offers considerable advantages over conventional vials. Almost all major biotech molecules are available on the market today in prefilled syringes, and are safe and efficacious. Newer high-concentration liquid formulations, especially fusion proteins, however, can suffer from instability in prefilled syringes due to syringe components like silicone oil. To assess the effect of siliconized and modified syringe surfaces on protein formulations, the stability of the recombinant protective antigen (rPA) for anthrax, abatacept, a fusion protein formulation with known silicone oil sensitivity, and an antistaphylococcal enterotoxin B (anti-SEB) monoclonal antibody (mAb) was assessed in siliconized, uncoated, and BD-42-coated (a proprietary coating developed by BD Technologies) prefilled syringes under different conditions. Both the soluble protein content and the number of subvisible particles were followed over time. When filled in siliconized syringes, all three protein solutions showed increased number of subvisible particles relative to uncoated or BD-42-coated syringes; the abatacept formulation with known silicone sensitivity also developed visible particles. Although rPA and anti-SEB mAb formulations mainly showed individual droplets, presumably of silicone, the abatacept formulation also showed droplets entangled in a fibrous structure. Uncoated glass and BD-42-coated syringes considerably reduced the formation of both visible and subvisible particles after immediate contact and after agitation. The anti-SEB mAb also adhered as a thin layer to the siliconized surface after agitation, irrespective of storage temperature. The development of visible particles could not be correlated with the loss of soluble protein fraction at protein concentrations above 4 mg/mL. It appears that protein formulations interact differently with different surfaces. The BD-42 coating appears to be a promising solution for packaging silicone-sensitive proteins in prefillable syringes and needs to be investigated further. It is demonstrated that BD-42 provides an inert surface with adequate lubrication while limiting the formation of visible and subvisible particles. It is hypothesized that these particles are formed due to the release of silicone droplets in the solution and result in the formation of silicone-induced visible aggregates. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100: 2563-2573, 2011 C1 [Majumdar, Sumit; Ford, Brandi M.; Mar, Kevin D.; Sullivan, Vince J.; D'Souza, Ajit Joseph M.] BD Technol, Res Triangle Pk, NC 27709 USA. [Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP D'Souza, AJM (reprint author), BD Technol, Res Triangle Pk, NC 27709 USA. EM ajit_dsouza@bd.com FU US Department of Defense [DAMD 17-03-2-0037] FX This work was funded in part by a grant from the US Department of Defense (Award No. DAMD 17-03-2-0037). NR 14 TC 45 Z9 46 U1 4 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3549 J9 J PHARM SCI-US JI J. Pharm. Sci. PD JUL PY 2011 VL 100 IS 7 BP 2563 EP 2573 DI 10.1002/jps.22515 PG 11 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 765RE UT WOS:000290725500006 PM 21319164 ER PT J AU Alfeeli, B Jain, V Johnson, RK Beyer, FL Heflin, JR Agah, M AF Alfeeli, Bassam Jain, Vaibhav Johnson, Richard K. Beyer, Frederick L. Heflin, James R. Agah, Masoud TI Characterization of poly(2,6-diphenyl-p-phenylene oxide) films as adsorbent for microfabricated preconcentrators SO MICROCHEMICAL JOURNAL LA English DT Article DE Microelectromechanical systems; Micro total analysis systems; Sample pretreatment; Micro gas chromatography; Polymeric adsorbents; Thin film adsorbents; Tenax TA ID VOLATILE ORGANIC-COMPOUNDS; GAS-CHROMATOGRAPHY; TENAX-TA; RETENTION CHARACTERISTICS; AMBIENT ATMOSPHERES; THERMAL-DESORPTION; VAPOR POLLUTANTS; AIR; PHASE; PERFORMANCE AB This work aims at evaluating poly(2,6-diphenyl-p-phenylene oxide) (Tenax TA), in the form of thin films, as an adsorbent material for various analytical applications. The physical properties of the polymer were studied with regard to surface topography, crystal structure, and thermal stability. Films deposited from solution at different substrate temperatures were studied and compared to the granular form of the polymer. It was found that Tenax TA deposited from solution have a different topography compared to their granular counterpart. The films possess a complex phase composition that includes crystalline and amorphous phases. The films showed high thermal stability (400 degrees C) similar to the granular form. The adsorption performance of the polymer compared to other possible adsorbent films such as polydimethylsiloxane (PDMS) and layer-by-layer assembled gold nanoparticles (GNPs) were also investigated. Representative volatile organic compound samples were used to compare the adsorption properties of Tenax TA films to that of the granules. (C) 2011 Elsevier B.V. All rights reserved. C1 [Alfeeli, Bassam; Agah, Masoud] Virginia Tech, VT MEMS Lab, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. [Jain, Vaibhav; Johnson, Richard K.] Virginia Tech, Macromol Sci & Engn, Blacksburg, VA 24061 USA. [Heflin, James R.] Virginia Tech, Dept Phys, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Alfeeli, Bassam] Kuwait Inst Sci Res, Kuwait 13109, Kuwait. RP Agah, M (reprint author), Virginia Tech, VT MEMS Lab, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. EM agah@vt.edu FU National Science Foundation [CBET-0854242]; Army Research Laboratory [W911NF-06-2-0014] FX We gratefully acknowledge the financial support from the National Science Foundation, award no. CBET-0854242. This work was also partially supported through the MultiTASC Materials Center of Excellence at Virginia Tech sponsored by the Army Research Laboratory under Cooperative Agreement Number W911NF-06-2-0014. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation hereon. NR 52 TC 11 Z9 12 U1 3 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0026-265X J9 MICROCHEM J JI Microchem J. PD JUL PY 2011 VL 98 IS 2 BP 240 EP 245 DI 10.1016/j.microc.2011.02.006 PG 6 WC Chemistry, Analytical SC Chemistry GA 766AD UT WOS:000290749600012 ER PT J AU Grujicic, M Glomski, PS Pandurangan, B Bell, WC Yen, CF Cheeseman, BA AF Grujicic, M. Glomski, P. S. Pandurangan, B. Bell, W. C. Yen, C-F. Cheeseman, B. A. TI Multi-length scale computational derivation of Kevlar((R)) yarn-level material model SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ARAMID FIBERS; FORCE-FIELD; VERIFICATION; COMPOSITES; MECHANICS; STRENGTH; COMPASS AB The results of an extensive set of molecular-level computational analyses regarding the role of various microstructural/morphological defects on the Kevlar(A (R)) fiber mechanical properties are used to upgrade the associated yarn-level model of the same material. While carrying out this analysis, the hierarchical multi-scale (atoms/ions-molecular chains-fibrils-fibers-yarn) of the problem was taken into account. To construct various defects, the appropriate open-literature experimental and computational results were used while the concentration of defects was set to the values comparable with their counterparts observed under "prototypical" polymers synthesis and fiber fabrication conditions. Due to the stochastic nature of the defect distributions, their effect on the yarn-level strength and ductility are included in the form of the corresponding two-level Weibull distribution. As far as the material stiffness is concerned, it was assumed that the first-order effect of the defects is to change the mean value of the stiffness parameters and that this effect is of a deterministic character. While upgrading the yarn-level material model for Kevlar(A (R)) it was recognized that a yarn is an assembly of nearly parallel fibers (often lightly twisted, or tied with wrap-around filaments) with relatively weak lateral coupling. C1 [Grujicic, M.; Glomski, P. S.; Pandurangan, B.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C-F.; Cheeseman, B. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory (ARL) [W911NF-06-2-0042] FX The material presented in this article is based on study supported by the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites,'' Contract Number W911NF-09-1-0513, and the Army Research Laboratory (ARL) research contract entitled "Computational Analysis and Modeling of Various Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil'' Contract Number W911NF-06-2-0042. The authors are indebted to Bruce LaMattina of ARO for his continuing support and interest in this study. NR 31 TC 16 Z9 16 U1 2 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL PY 2011 VL 46 IS 14 BP 4787 EP 4802 DI 10.1007/s10853-011-5389-8 PG 16 WC Materials Science, Multidisciplinary SC Materials Science GA 755CC UT WOS:000289903200007 ER PT J AU Woo, HJ Wallqvist, A AF Woo, Hyung-June Wallqvist, Anders TI Spontaneous Buckling of Lipid Bilayer and Vesicle Budding Induced by Antimicrobial Peptide Magainin 2: A Coarse-Grained Simulation Study SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; 2-INDUCED PORE FORMATION; ALPHA-HELICAL PEPTIDES; PHOSPHOLIPID-BILAYERS; ANTIBIOTIC PEPTIDE; NEUTRON-SCATTERING; FORCE-FIELD; FLIP-FLOP; MEMBRANES; MODEL AB olecular mechanisms of the action of antimicrobial peptides on bacterial membranes were studied by large scale coarse-grained simulations of magainin 2-dipalmitoylphosphatidylcholine/palmitoyloleoylphosphatidylglycerol (DPPC/POPG) mixed bilayer systems with spatial extents up to 0.1 mu m containing up to 1600 peptides. Equilibrium simulations exhibit disordered toroidal pores stabilized by peptides. However, when a layer of peptides is placed near the lipid head groups on one side of the bilayer only, their incorporation leads to a spontaneous buckling of the bilayer. This buckling is followed by the formation of a quasi-spherical vesicular bud connected to the bilayer by a narrow neck. The mean curvature of the budding region is consistent with what is expected based on the dependence of the area per lipid on the peptide-to-lipid ratio in equilibrium simulations. Our simulations suggest that the incorporation of antimicrobial peptides on the exterior surface of a vesicle or a bacterial cell leads to buckling and vesicle budding, presumably accompanied by nucleations of giant transient pores of sizes that are much larger than indicated by equilibrium measurements and simulations. C1 [Woo, Hyung-June; Wallqvist, Anders] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Woo, HJ (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM woo@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT); Department of Defense (DoD); U.S. Army Medical Research and Materiel Command FX We thank Dr. In-Chul Yeh for helpful discussions. This work was funded in part by a competitive In-house Laboratory Independent Research (ILIR) award by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT) and by the Department of Defense (DoD) High Performance Computing (HPC) Modernization Program Office, under the HPC Software Applications Institute initiative, the U.S. Army Medical Research and Materiel Command. Computational time was provided by the U.S. Army Research Laboratory and Navy DoD Supercomputing Resource Centers. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for unlimited public release. NR 48 TC 30 Z9 30 U1 1 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD JUN 30 PY 2011 VL 115 IS 25 BP 8122 EP 8129 DI 10.1021/jp2023023 PG 8 WC Chemistry, Physical SC Chemistry GA 780YB UT WOS:000291896200009 PM 21651300 ER PT J AU Chantawansri, TL Hur, SM Garcia-Cervera, CJ Ceniceros, HD Fredrickson, GH AF Chantawansri, Tanya L. Hur, Su-Mi Garcia-Cervera, Carlos J. Ceniceros, Hector D. Fredrickson, Glenn H. TI Spectral collocation methods for polymer brushes SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article DE convergence of numerical methods; free energy; mixing; polymer melts; SCF calculations; self-assembly ID STRONG-STRETCHING THEORY; PARTIAL-DIFFERENTIAL-EQUATIONS; CONSISTENT-FIELD THEORY; BLOCK-COPOLYMER; DIBLOCK COPOLYMER; GRAFTED POLYMERS; THIN-FILMS; HOMOPOLYMER; ATTRACTION; ADSORPTION AB We provide an in-depth study of pseudo-spectral numerical methods associated with modeling the self-assembly of molten mixed polymer brushes in the framework of self-consistent field theory (SCFT). SCFT of molten polymer brushes has proved numerically challenging in the past because of sharp features that arise in the self-consistent pressure field at the grafting surface due to the chain end tethering constraint. We show that this pressure anomaly can be reduced by smearing the grafting points over a narrow zone normal to the surface in an incompressible model, and/or by switching to a compressible model for the molten brush. In both cases, we use results obtained from a source (delta function) distribution of grafting points as a reference. At the grafting surface, we consider both Neumann and Dirichlet conditions, where the latter is paired with a masking method to mimic a confining surface. When only the density profiles and relative free energies of two comparison phases are of interest, either source or smeared distributions of grafting points can be used, but a smeared distribution of grafting points exhibits faster convergence with respect to the number of chain contour steps. Absolute free energies converge only within the smeared model. In addition, when a sine basis is used with the masking method and a smeared distribution, fewer iterations are necessary to converge the SCFT fields for the compressible model. The numerical methods described here and investigated in one-dimension will provide an enabling platform for computationally more demanding three-dimensional SCFT studies of a broad range of mixed polymer brush systems. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3604814] C1 [Chantawansri, Tanya L.; Hur, Su-Mi; Fredrickson, Glenn H.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Chantawansri, Tanya L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Garcia-Cervera, Carlos J.; Ceniceros, Hector D.] Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA. [Hur, Su-Mi; Fredrickson, Glenn H.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Fredrickson, Glenn H.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Fredrickson, GH (reprint author), Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. EM ghf@mrl.ucsb.edu RI Chantawansri, Tanya/N-3601-2013 FU National Science Foundation (NSF) [DMR09-04499, DMR05-20415, DMS10-16310] FX This work was supported by National Science Foundation (NSF) Grant No. DMR09-04499 and made use of MRL Central Facilities supported by the MRSEC Program of the NSF under Grant No. DMR05-20415. H. D. C. was partially supported by NSF grant No. DMS10-16310. NR 51 TC 15 Z9 15 U1 1 U2 20 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 28 PY 2011 VL 134 IS 24 AR 244905 DI 10.1063/1.3604814 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 786TX UT WOS:000292331900060 PM 21721662 ER PT J AU Lee, MS Olson, MA AF Lee, Michael S. Olson, Mark A. TI Comparison of two adaptive temperature-based replica exchange methods applied to a sharp phase transition of protein unfolding-folding SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article DE biochemistry; cooling; heating; molecular biophysics; molecular dynamics method; phase transformations; proteins ID MOLECULAR-DYNAMICS SIMULATIONS; GUIDED LANGEVIN DYNAMICS; SH3 AB Temperature-based replica exchange (T-ReX) enhances sampling of molecular dynamics simulations by autonomously heating and cooling simulation clients via a Metropolis exchange criterion. A pathological case for T-ReX can occur when a change in state (e. g., folding to unfolding of a protein) has a large energetic difference over a short temperature interval leading to insufficient exchanges amongst replica clients near the transition temperature. One solution is to allow the temperature set to dynamically adapt in the temperature space, thereby enriching the population of clients near the transition temperature. In this work, we evaluated two approaches for adapting the temperature set: a method that equalizes exchange rates over all neighbor temperature pairs and a method that attempts to induce clients to visit all temperatures (dubbed "current maximization") by positioning many clients at or near the transition temperature. As a test case, we simulated the 57-residue SH3 domain of alpha-spectrin. Exchange rate equalization yielded the same unfolding-folding transition temperature as fixed-temperature ReX with much smoother convergence of this value. Surprisingly, the current maximization method yielded a significantly lower transition temperature, in close agreement with experimental observation, likely due to more extensive sampling of the transition state. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3603964] C1 [Lee, Michael S.] USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. [Lee, Michael S.; Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. RP Lee, MS (reprint author), USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. EM michael.scott.lee@us.army.mil FU DTRA [CBM.THRV.01.10.RD.012, TMTI0004_09_BH_T] FX We thank Dr. S. Chaudhury and Dr. I.-C. Yeh for helpful discussions. M.S.L. and M.A.O. acknowledge funding from DTRA Grant No. CBM.THRV.01.10.RD.012 and computer time from the U. S. Army Research Laboratory Department of Defense Supercomputing Resource Center. M.A.O. acknowledges funding from DTRA TMTI0004_09_BH_T. NR 20 TC 13 Z9 13 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 28 PY 2011 VL 134 IS 24 AR 244111 DI 10.1063/1.3603964 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 786TX UT WOS:000292331900014 PM 21721616 ER PT J AU Williams, RL AF Williams, Roger L. TI MEDICINE QUALITY FACES CHALLENGES SO CHEMICAL & ENGINEERING NEWS LA English DT Editorial Material C1 [Williams, Roger L.] USA, Washington, DC USA. [Williams, Roger L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Williams, Roger L.] US FDA, Rockville, MD 20857 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0009-2347 J9 CHEM ENG NEWS JI Chem. Eng. News PD JUN 27 PY 2011 VL 89 IS 26 BP 58 EP 59 PG 2 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA 787BU UT WOS:000292352400051 ER PT J AU Turalska, M West, BJ Grigolini, P AF Turalska, Malgorzata West, Bruce J. Grigolini, Paolo TI Temporal complexity of the order parameter at the phase transition SO PHYSICAL REVIEW E LA English DT Article ID SYNCHRONIZATION; NETWORKS; CRITICALITY; STATISTICS; DYNAMICS AB We study a decision making model in a condition where it is equivalent to the two-dimensional Ising model, and we show that at the onset of phase transition it generates temporal complexity, namely, nonstationary and nonergodic fluctuations. We argue that this is a general property of criticality, thereby opening the door to the application of the recently discovered phenomenon of complexity matching: For an efficient transfer of information to occur, a perturbing complex network must share the same temporal complexity as the perturbed complex network. C1 [Turalska, Malgorzata; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC 27709 USA. RP Turalska, M (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. RI West, Bruce/E-3944-2017 FU ARO [W911NF-05-1-0205]; Welch [B-1577] FX M.G. and P.G. acknowledge financial support from ARO and Welch through Grants No. W911NF-05-1-0205 and No. B-1577, respectively. NR 37 TC 37 Z9 37 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD JUN 24 PY 2011 VL 83 IS 6 AR 061142 DI 10.1103/PhysRevE.83.061142 PN 1 PG 6 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 821QI UT WOS:000294989100004 PM 21797337 ER PT J AU Hulten, EA Petrillo, SP Villines, TC AF Hulten, Edward A. Petrillo, Sara P. Villines, Todd C. TI Prognostic Value of Cardiac Computed Tomography Angiography Reply SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Letter C1 [Hulten, Edward A.; Petrillo, Sara P.; Villines, Todd C.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Hulten, EA (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. EM eddiehulten@gmail.com OI Hulten, Edward/0000-0001-9281-0032 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD JUN 21 PY 2011 VL 57 IS 25 BP 2544 EP 2545 DI 10.1016/j.jacc.2011.03.018 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 777RI UT WOS:000291641800016 ER PT J AU Henz, BJ Chung, PW Andzelm, JW Chantawansri, TL Lenhart, JL Beyer, FL AF Henz, Brian J. Chung, Peter W. Andzelm, Jan W. Chantawansri, Tanya L. Lenhart, Joseph L. Beyer, Frederick L. TI Determination of Binding Energy and Solubility Parameters for Functionalized Gold Nanoparticles by Molecular Dynamics Simulation SO LANGMUIR LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; ALKANETHIOLS; AU(111); NANOCOMPOSITES; IMPURITIES; METALS; ARRAYS; MODEL; STATE AB The binding energy, density, and solubility of functionalized gold nanoparticles in a vacuum are computed using molecular dynamics simulations. Numerous parameters including surface coverage fraction, functional group (-CH(3), -OH, -NH(2)), and nanoparticle orientation are considered. The analysis includes computation of minimum interparticle binding distances and energies and an analysis of mechanisms that may contribute to changes in system potential energy. A number of interesting trends and results are observed, such as increasing binding distance with higher terminal group electro-negativity and a minimum particle particle binding energy (solubility parameter) based upon surface coverage. These results provide a fundamental understanding of ligand-coated nanoparticle interactions required for the design and processing of high-density polymer composites. The computational model and results are presented as support for these conclusions. C1 [Henz, Brian J.; Chung, Peter W.; Andzelm, Jan W.; Chantawansri, Tanya L.; Lenhart, Joseph L.; Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Henz, BJ (reprint author), USA, Res Lab, ATTN, RDRL CIH C Adv Comp & Computat Sci Div APG, Aberdeen Proving Ground, MD 21005 USA. EM brian.j.henz@us.army.mil RI Chantawansri, Tanya/N-3601-2013 FU U.S. Army Research Laboratory's Director's Strategic Initiative; DoD shared resource center (DSRC) at the Aberdeen Proving Grounds, Maryland; U.S. Department of Energy; U.S. Army Research Laboratory FX The authors gratefully acknowledge support through the U.S. Army Research Laboratory's Director's Strategic Initiative and the DoD shared resource center (DSRC) at the Aberdeen Proving Grounds, Maryland. Tanya L. Chantawansri was supported by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory. NR 32 TC 9 Z9 9 U1 3 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUN 21 PY 2011 VL 27 IS 12 BP 7836 EP 7842 DI 10.1021/la2005024 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 775YX UT WOS:000291500700065 PM 21591643 ER PT J AU Gonzaga, VE Ramos, M Maves, RC Freeman, R Montgomery, JM AF Gonzaga, Victor E. Ramos, Mariana Maves, Ryan C. Freeman, Randal Montgomery, Joel M. TI Concurrent Outbreak of Norovirus Genotype I and Enterotoxigenic Escherichia coli on a US Navy Ship following a Visit to Lima, Peru SO PLOS ONE LA English DT Article ID VIRUS-INFECTION; UNITED-STATES; GASTROENTERITIS; TRAVELERS; DIARRHEA; DISEASE; PCR AB An outbreak of norovirus (NoV) genotype I and Enterotoxigenic Escherichia coli (ETEC) occurred among US Navy Ship personnel following a visit to Lima, Peru, in June 2008. Visiting a specific area in Lima was significantly associated with illness. While ETEC and NoV are commonly recognized as causative agents of outbreaks, co-circulation of both pathogens has been rarely observed in shipboard outbreaks. C1 [Gonzaga, Victor E.; Ramos, Mariana; Maves, Ryan C.; Montgomery, Joel M.] United States Naval Med Res Unit Six NAMRU 6, Lima, Peru. [Freeman, Randal] USA, El Paso, TX USA. RP Gonzaga, VE (reprint author), United States Naval Med Res Unit Six NAMRU 6, Lima, Peru. EM jmontgomery@ke.cdc.gov RI Valle, Ruben/A-7512-2013 FU AFHSC-GEIS [847705 82000 25GB B0016] FX This study was supported by grant AFHSC-GEIS, work unit number 847705 82000 25GB B0016. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U. S. Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 14 TC 7 Z9 7 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 21 PY 2011 VL 6 IS 6 AR e20822 DI 10.1371/journal.pone.0020822 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 782CL UT WOS:000291985100005 PM 21713034 ER PT J AU Grove, JN Branco, LM Boisen, ML Muncy, IJ Henderson, LA Schieffellin, JS Robinson, JE Bangura, JJ Fonnie, M Schoepp, RJ Hensley, LE Seisay, A Fair, JN Garry, RF AF Grove, Jessica N. Branco, Luis M. Boisen, Matt L. Muncy, Ivana J. Henderson, Lee A. Schieffellin, John S. Robinson, James E. Bangura, James J. Fonnie, Mbalu Schoepp, Randal J. Hensley, Lisa E. Seisay, Alhassan Fair, Joseph N. Garry, Robert F. TI Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: Case Report SO VIROLOGY JOURNAL LA English DT Article ID WEST-AFRICA; MANAGEMENT; GERMANY; VIRUS AB Lassa fever is a neglected tropical disease with a significant impact on the health care system of endemic West African nations. To date, case reports of Lassa fever have focused on laboratory characterisation of serological, biochemical and molecular aspects of the disease imported by infected individuals from Western Africa to the United States, Canada, Europe, Japan and Israel. Our report presents the first comprehensive real time diagnosis and characterization of a severe, hemorrhagic Lassa fever case in a Sierra Leonean individual admitted to the Kenema Government Hospital Lassa Fever Ward. Fever, malaise, unresponsiveness to anti-malarial and antibiotic drugs, followed by worsening symptoms and onset of haemorrhaging prompted medical officials to suspect Lassa fever. A recombinant Lassa virus protein based diagnostic was employed in diagnosing Lassa fever upon admission. This patient experienced a severe case of Lassa hemorrhagic fever with dysregulation of overall homeostasis, significant liver and renal system involvement, the interplay of pro- and anti-inflammatory cytokines during the course of hospitalization and an eventual successful outcome. These studies provide new insights into the pathophysiology and management of this viral illness and outline the improved infrastructure, research and real-time diagnostic capabilities within LASV endemic areas. C1 [Grove, Jessica N.; Branco, Luis M.; Garry, Robert F.] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA. [Branco, Luis M.] Autoimmune Technol LLC, New Orleans, LA USA. [Boisen, Matt L.; Muncy, Ivana J.] Corgenix Med Corp, Broomfield, CO USA. [Henderson, Lee A.] Vybion Inc, Ithaca, NY USA. [Schieffellin, John S.; Robinson, James E.] Tulane Univ, Dept Pediat, Infect Dis Sect, New Orleans, LA 70118 USA. [Bangura, James J.; Fair, Joseph N.] Global Viral Forecasting Initiat, San Francisco, CA USA. [Fonnie, Mbalu] Kenema Govt Hosp Lassa Fever Ward, Kenema, Sierra Leone. [Schoepp, Randal J.] USA, Med Res Inst Infect Dis, Appl Diagnost Branch, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Viral Therapeut Branch, Diagnost Syst Div,Div Virol, Ft Detrick, MD 21702 USA. RP Garry, RF (reprint author), Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA. EM rfgarry@tulane.edu FU Louisiana Board of Regents [AI067188, AI082119, RC-0013-07]; Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases Challenge FX This work was supported by Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases Challenge and Partnership Grant Numbers AI067188 and AI082119, and RC-0013-07 from the Louisiana Board of Regents. We thank the members of the Hemorrhagic Fever Diagnostic Consortium, and Lassa Fever - Mano River Union for ongoing support. Additionally we thank the Ministry of Health in Sierra Leone and the members of the KGH Lassa Fever team including Michael A. Gbakie, Alex G. Moiboi, Alice B. Kovoma, Patrick B. Sannoh, Veronica J. Koroma, Veronica Tucker, Edwin Konuwa, Vandy Sinnah, Fatima Kamara, Sidikie Saffa and Lansana Kanneh for their dedication to this project. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 38 TC 17 Z9 17 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUN 20 PY 2011 VL 8 AR 314 DI 10.1186/1743-422X-8-314 PG 14 WC Virology SC Virology GA 808GB UT WOS:000293964200001 PM 21689444 ER PT J AU Peck, AR Witkiewicz, AK Liu, CB Stringer, GA Klimowicz, AC Pequignot, E Freydin, B Tran, TH Yang, N Rosenberg, AL Hooke, JA Kovatich, AJ Nevalainen, MT Shriver, CD Hyslop, T Sauter, G Rimm, DL Magliocco, AM Rui, H AF Peck, Amy R. Witkiewicz, Agnieszka K. Liu, Chengbao Stringer, Ginger A. Klimowicz, Alexander C. Pequignot, Edward Freydin, Boris Tran, Thai H. Yang, Ning Rosenberg, Anne L. Hooke, Jeffrey A. Kovatich, Albert J. Nevalainen, Marja T. Shriver, Craig D. Hyslop, Terry Sauter, Guido Rimm, David L. Magliocco, Anthony M. Rui, Hallgeir TI Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID AUTOMATED QUANTITATIVE-ANALYSIS; MAMMARY EPITHELIAL-CELLS; SOUTHWEST-ONCOLOGY-GROUP; GROWTH-FACTOR RECEPTOR; PROGESTERONE-RECEPTOR; TISSUE MICROARRAYS; SIGNAL TRANSDUCER; ENDOCRINE THERAPY; PROTEIN EXPRESSION; TAMOXIFEN RESPONSE AB Purpose To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5) as a marker of prognosis in node-negative breast cancer and as a predictor of response to antiestrogen therapy. Patients and Methods Levels of Nuc-pYStat5 were analyzed in five archival cohorts of breast cancer by traditional diaminobenzidine-chromogen immunostaining and pathologist scoring of whole tissue sections or by immunofluorescence and automated quantitative analysis (AQUA) of tissue microarrays. Results Nuc-pYStat5 was an independent prognostic marker as measured by cancer-specific survival (CSS) in patients with node-negative breast cancer who did not receive systemic adjuvant therapy, when adjusted for common pathology parameters in multivariate analyses both by standard chromogen detection with pathologist scoring of whole tissue sections (cohort I; n = 233) and quantitative immunofluorescence of a tissue microarray (cohort II; n = 291). Two distinct monoclonal antibodies gave concordant results. A progression array (cohort III; n = 180) revealed frequent loss of Nuc-pYStat5 in invasive carcinoma compared to normal breast epithelia or ductal carcinoma in situ, and general loss of Nuc-pYStat5 in lymph node metastases. In cohort IV (n = 221), loss of Nuc-pYStat5 was associated with increased risk of antiestrogen therapy failure as measured by univariate CSS and time to recurrence (TTR). More sensitive AQUA quantification of Nuc-pYStat5 in antiestrogen-treated patients (cohort V; n = 97) identified by multivariate analysis patients with low Nuc-pYStat5 at elevated risk for therapy failure (CSS hazard ratio [HR], 21.55; 95% CI, 5.61 to 82.77; P < .001; TTR HR, 7.30; 95% CI, 2.34 to 22.78; P = .001). Conclusion Nuc-pYStat5 is an independent prognostic marker in node-negative breast cancer. If confirmed in prospective studies, Nuc-pYStat5 may become a useful predictive marker of response to adjuvant hormone therapy. C1 [Rui, Hallgeir] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA. MDR Global Syst, Windber, PA USA. Alberta Canc Board, Tom Baker Canc Ctr, Calgary, AB, Canada. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. Yale Univ, Sch Med, New Haven, CT USA. RP Rui, H (reprint author), Thomas Jefferson Univ, Kimmel Canc Ctr, 233 S 10th St, Philadelphia, PA 19107 USA. EM hallgeir.rui@jefferson.edu FU National Institutes of Health [R01-CA101841, R01-CA118740]; Komen for the Cure [KG091116]; Department of Defense [BC051251]; National Cancer Institute [1P30CA56036]; Commonwealth University; Pennsylvania Department of Health FX Supported by Grants No. R01-CA101841 and R01-CA118740 from the National Institutes of Health (H. R.), Promise Grant No. KG091116 from Komen for the Cure (H. R., A. K. W., C. L., J.A.H., A.J.K., C. D. S., T. H.), Department of Defense CDMRP Predoctoral Fellowship No. BC051251 (A. R. P.), support Grant No. 1P30CA56036 from the National Cancer Institute to the Kimmel Cancer Center; and, in part, under a Commonwealth University Research Enhancement Program grant with the Pennsylvania Department of Health (H. R.). The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense, or US Government. NR 45 TC 46 Z9 47 U1 0 U2 3 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUN 20 PY 2011 VL 29 IS 18 BP 2448 EP 2458 DI 10.1200/JCO.2010.30.3552 PG 11 WC Oncology SC Oncology GA 778EQ UT WOS:000291684600018 PM 21576635 ER PT J AU Gullapalli, H Reddy, ALM Kilpatrick, S Dubey, M Ajayan, PM AF Gullapalli, Hemtej Reddy, Arava Leela Mohana Kilpatrick, Stephen Dubey, Madan Ajayan, Pulickel M. TI Graphene Growth via Carburization of Stainless Steel and Application in Energy Storage SO SMALL LA English DT Article ID LITHIUM ION BATTERIES; CARBON; INTERCALATION; FILMS; ELECTRODES; PERFORMANCE; GRAPHITE AB A modified version of the carburization process, a widely established technique used in the steel industry for case hardening of components, is used for the growth of graphene on stainless steel. Controlled growth of high-quality single- and few-layered graphene on stainless steel (SS) foils through a liquid-phase chemical vapor deposition (CVD) technique is reported. Reversible Li intercalation in these graphene-on-SS structures is demonstrated, where graphene and SS act as electrode and current collector, respectively, providing very good electrical contact. Direct growth of an active electrode material, such as graphene, on current-collector substrates makes this a feasible and efficient process for developing thin-film battery devices. C1 [Gullapalli, Hemtej; Reddy, Arava Leela Mohana; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Kilpatrick, Stephen; Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. RP Ajayan, PM (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. EM ajayan@rice.edu RI Arava, Leela Mohana Reddy/J-3180-2015; Gullapalli, Hemtej/P-7247-2014 OI Gullapalli, Hemtej/0000-0003-1520-4287 FU Army Research Office; Advanced Energy Consortium FX L.M.R. acknowledges funding support from the Army Research Office. P. M. A. and H. G. acknowledge support from the Advanced Energy Consortium. NR 22 TC 24 Z9 24 U1 1 U2 45 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1613-6810 J9 SMALL JI Small PD JUN 20 PY 2011 VL 7 IS 12 BP 1697 EP 1700 DI 10.1002/smll.201100111 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 777DP UT WOS:000291595800013 PM 21538990 ER PT J AU Chanturia, G Birdsell, DN Kekelidze, M Zhgenti, E Babuadze, G Tsertsvadze, N Tsanava, S Imnadze, P Beckstrom-Sternberg, SM Beckstrom-Sternberg, JS Champion, MD Sinari, S Gyuranecz, M Farlow, J Pettus, AH Kaufman, EL Busch, JD Pearson, T Foster, JT Vogler, AJ Wagner, DM Keim, P AF Chanturia, Gvantsa Birdsell, Dawn N. Kekelidze, Merab Zhgenti, Ekaterine Babuadze, George Tsertsvadze, Nikoloz Tsanava, Shota Imnadze, Paata Beckstrom-Sternberg, Stephen M. Beckstrom-Sternberg, James S. Champion, Mia D. Sinari, Shripad Gyuranecz, Miklos Farlow, Jason Pettus, Amanda H. Kaufman, Emily L. Busch, Joseph D. Pearson, Talima Foster, Jeffrey T. Vogler, Amy J. Wagner, David M. Keim, Paul TI Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia SO BMC MICROBIOLOGY LA English DT Article ID TANDEM REPEAT ANALYSIS; UNITED-STATES; IDENTIFICATION; TULAREMIA; PCR; EPIDEMIOLOGY; POPULATIONS; EVOLUTION; NOVICIDA; STRAINS AB Background: Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B. Br. 013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context. Results: We identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B. Br. 013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B. Br. 013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B. Br. 013 group, indicating the Georgian lineage diverged before the diversification of the other known B. Br. 013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation. Conclusions: We identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B. Br. 013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies. C1 [Birdsell, Dawn N.; Pettus, Amanda H.; Kaufman, Emily L.; Busch, Joseph D.; Pearson, Talima; Foster, Jeffrey T.; Vogler, Amy J.; Wagner, David M.; Keim, Paul] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Chanturia, Gvantsa; Kekelidze, Merab; Zhgenti, Ekaterine; Babuadze, George; Tsertsvadze, Nikoloz; Tsanava, Shota; Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, GE-0177 Tbilisi, Rep of Georgia. [Beckstrom-Sternberg, James S.; Champion, Mia D.; Sinari, Shripad] Translat Genom Res Inst, Phoenix, AZ 85004 USA. [Gyuranecz, Miklos] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary. [Farlow, Jason] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Keim, P (reprint author), No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. EM Paul.Keim@nau.edu RI Keim, Paul/A-2269-2010; OI Foster, Jeffrey/0000-0001-8235-8564 FU U.S. Department of Homeland Security S&T CB Division Bioforensics FX This work was funded by the U.S. Department of Homeland Security S&T CB Division Bioforensics R&D Program. Note that the use of products/names does not constitute endorsement by the Department of Homeland Security of the United States. NR 41 TC 18 Z9 19 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD JUN 17 PY 2011 VL 11 AR 139 DI 10.1186/1471-2180-11-139 PG 10 WC Microbiology SC Microbiology GA 793QZ UT WOS:000292839500001 PM 21682874 ER PT J AU Linkov, I Seager, TP AF Linkov, Igor Seager, Thomas P. TI Coupling Multi-Criteria Decision Analysis, Life-Cycle Assessment, and Risk Assessment for Emerging Threats SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID CONTAMINATED SEDIMENTS; IMPACT ASSESSMENT; MANAGEMENT; NANOMATERIALS; REMEDIATION C1 [Linkov, Igor] USA, Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Seager, Thomas P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. RP Linkov, I (reprint author), USA, Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil FU U.S. Department of Homeland Security; Civil Works Basic Research Program; U.S. Army Engineer Research and Development Center (ERDC) FX We thank Mr. Magnus Sparrevik for helpful conversations and contributions to the sediments example. We also lthank Dr. Jeff Keisler, Ms. Laure Canis, Mr. Alex Tkachuk, and Dr. James Lambert for advice and helpful discussions. Editorial and technical assistance from Benjamin Trump and John Vogel is greatly appreciated. This effort was sponsored in part by the U.S. Department of Homeland Security and by Civil Works Basic Research Program by the U.S. Army Engineer Research and Development Center (ERDC). Additional funding was provided through the ERDC Nanotechnology Focus Area. Permission was granted by the USACE Chief of Engineers to publish this material. NR 36 TC 55 Z9 59 U1 1 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 15 PY 2011 VL 45 IS 12 BP 5068 EP 5074 DI 10.1021/es100959q PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 774YH UT WOS:000291422200003 PM 21524065 ER PT J AU Truex, MJ Macbeth, TW Vermeul, VR Fritz, BG Mendoza, DP Mackley, RD Wietsma, TW Sandberg, G Powell, T Powers, J Pitre, E Michalsen, M Ballock-Dixon, SJ Zhong, L Oostrom, M AF Truex, M. J. Macbeth, T. W. Vermeul, V. R. Fritz, B. G. Mendoza, D. P. Mackley, R. D. Wietsma, T. W. Sandberg, G. Powell, T. Powers, J. Pitre, E. Michalsen, M. Ballock-Dixon, S. J. Zhong, L. Oostrom, M. TI Demonstration of Combined Zero-Valent Iron and Electrical Resistance Heating for In Situ Trichloroethene Remediation SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NONAQUEOUS PHASE LIQUIDS; REDUCTIVE DECHLORINATION; POROUS-MEDIA; CHLORINATED ETHYLENES; ZEROVALENT IRON; SOURCE ZONES; DISSOLUTION; TETRACHLOROETHENE; SYSTEMS; DEGRADATION AB The effectiveness of in situ treatment using zero-valent iron (ZVI) for nonaqueous phase or significant sediment-associated contaminant mass can be limited by relatively low rates of mass transfer to bring contaminants in contact with the reactive media. For a field test in a trichloroethene (TCE) source area, combining moderate-temperature subsurface electrical resistance heating with in situ ZVI treatment was shown to accelerate TCE treatment by a factor of about 4 based on organic daughter products and a factor about 8 based on chloride concentrations. A mass-discharge-based analysis was used to evaluate reaction, dissolution, and volatilization processes at ambient groundwater temperature (similar to 10 degrees C) and as temperature was increased up to about 50 degrees C. Increased reaction and contaminant dissolution were observed with increased temperature, but vapor- or aqueous-phase migration of TCE out of the treatment zone was minimal during the test because reactions maintained low aqueous-phase TCE concentrations. C1 [Truex, M. J.; Vermeul, V. R.; Fritz, B. G.; Mendoza, D. P.; Mackley, R. D.; Wietsma, T. W.; Zhong, L.; Oostrom, M.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Macbeth, T. W.] CDM, Helena, MT 59601 USA. [Sandberg, G.; Powell, T.] TRS Grp Inc, Longview, WA 98632 USA. [Powers, J.; Pitre, E.; Michalsen, M.] USA, Environm Engn & Technol Sect, Corps Engineers, Seattle, WA 98134 USA. [Ballock-Dixon, S. J.] N Wind Inc, Idaho Falls, ID 83402 USA. RP Truex, MJ (reprint author), Pacific NW Natl Lab, 902 Battelle Blvd, Richland, WA 99352 USA. EM mj.truex@pnl.gov FU Department of Defense [ER-0719] FX This work was funded by the Department of Defense Environmental Security Technology Certification Program (ESTCP), project ER-0719. A portion of the supplementary laboratory experiments were conducted in the William It Wiley Environmental Molecular Sciences Laboratory, a Department of Energy user facility operated by PNNL. NR 31 TC 19 Z9 19 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 15 PY 2011 VL 45 IS 12 BP 5346 EP 5351 DI 10.1021/es104266a PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 774YH UT WOS:000291422200042 PM 21591672 ER PT J AU Cain, N Roberts, G Kiserow, D Carbonell, R AF Cain, Nathaniel Roberts, George Kiserow, Douglas Carbonell, Ruben TI Modeling the thermodynamic and transport properties of decahydronaphthalene/propane mixtures: Phase equilibria, density, and viscosity SO FLUID PHASE EQUILIBRIA LA English DT Article DE Phase equilibria; Modified Sanchez-Lacombe Equation of State; Decahydronaphthalene; Propane; density; Viscosity; Volume expansion; Viscosity reduction; Free volume model for viscosity ID EQUATION-OF-STATE; HIGH-PRESSURE; DYNAMIC VISCOSITY; CO2-EXPANDED SOLVENTS; CARBON-DIOXIDE; REPRESENTATIVE MODELS; HYDROCARBON MIXTURES; POLYMER-SOLUTIONS; LIQUID-LIQUID; CIS-DECALIN AB The density and viscosity of propane mixed with 66/34 trans/cis-decahyclronaphthalene were measured over a wide range of temperatures (323-423 K), pressures (2.5-208 bar), and compositions (0-65 mol% propane). For conditions giving two phases, the composition of the dense phase was measured in addition to the density and viscosity. The modified Sanchez-Lacombe Equation of State (MSLEOS) was used with a single linearly temperature-dependent pseudo-binary interaction parameter to correlate the phase compositions and densities. The compositions and densities of the mixtures were captured well with absolute average deviations between the model and the data of 5.3% and 2.3%, respectively. The mixture viscosities were computed from a free volume model (FVM) by using a single constant binary interaction parameter. Density predictions from the MSLEOS were used as input mixture density values required for the FVM. The FVM was found to correlate well with the mixture viscosity data with an absolute average deviation between the model and the data of 5.7%. (C) 2011 Elsevier B.V. All rights reserved. C1 [Cain, Nathaniel; Roberts, George; Kiserow, Douglas; Carbonell, Ruben] N Carolina State Univ, Dept Chem & Bimol Engn, Raleigh, NC 27606 USA. [Kiserow, Douglas] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Carbonell, R (reprint author), N Carolina State Univ, Dept Chem & Bimol Engn, 1017 Main Campus Dr,Partners Bldg 1,Suite 3200,Bo, Raleigh, NC 27606 USA. EM ruben@ncsu.edu RI Carbonell, Ramon/C-7847-2014 OI Carbonell, Ramon/0000-0003-2019-1214 FU National Science Foundation [9876674] FX This research was funded by the National Science Foundation agreement # 9876674. NR 41 TC 6 Z9 6 U1 2 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD JUN 15 PY 2011 VL 305 IS 1 BP 25 EP 33 DI 10.1016/j.fluid.2011.02.009 PG 9 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 776DB UT WOS:000291513600004 ER PT J AU Pankow, M Salvi, A Waas, AM Yen, CF Ghiorse, S AF Pankow, M. Salvi, A. Waas, A. M. Yen, C. F. Ghiorse, S. TI Split Hopkinson pressure bar testing of 3D woven composites SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Impact behaviour; Braiding; Mechanical properties; Textile composites; Delamination; Plastic Deformation ID COMPRESSIVE FAILURE; BRAIDED COMPOSITES; STRAIN RATES; BEHAVIOR AB Results from a series of split Hopkinson pressure bar (SHPB) tests on 3D woven tetxile composites (3DWC) are presented. These tests were done to determine the rate dependent compression response of 3DWC. Three different configurations of the 3DWC, corresponding to compression response in the plane of the material and through-the-thickness direction (out-of-plane) were studied. The rate dependent responses were compared against quasi-static test results and it was found that 3DWC showed an increase in strength in all three directions studied, however, accompanied by a transition in the failure mechanism. The in-plane orientations showed the largest increase in (about 100%) strength at the elevated rates of loading. A follow-on paper provides finite element based results that correspond to the experimental results presented here. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Pankow, M.; Salvi, A.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Yen, C. F.; Ghiorse, S.] Army Res Labs, Aberdeen Proving Ground, MD USA. RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA. EM dcw@umich.edu FU Army Research Laboratories, Aberdeen FX The authors would like to thank the Army Research Laboratories, Aberdeen proving ground, for their continued financial support. NR 20 TC 17 Z9 17 U1 1 U2 37 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN 15 PY 2011 VL 71 IS 9 BP 1196 EP 1208 DI 10.1016/j.compscitech.2011.03.017 PG 13 WC Materials Science, Composites SC Materials Science GA 787CC UT WOS:000292353200003 ER PT J AU Crum-Cianflone, NF Wilkins, K Lee, AW Grosso, A Landrum, ML Weintrob, A Ganesan, A Maguire, J Klopfer, S Brandt, C Bradley, WP Wallace, MR Agan, BK AF Crum-Cianflone, Nancy F. Wilkins, Kenneth Lee, Andrew W. Grosso, Anthony Landrum, Michael L. Weintrob, Amy Ganesan, Anuradha Maguire, Jason Klopfer, Stephanie Brandt, Carolyn Bradley, William P. Wallace, Mark R. Agan, Brian K. CA Infect Dis Clinical Res Program HI TI Long-term Durability of Immune Responses After Hepatitis A Vaccination Among HIV-Infected Adults SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; ANTIBODY-RESPONSES; HOMOSEXUAL-MEN; IMMUNOGENICITY; INDIVIDUALS; SAFETY; PROTECTION; VAQTA(R); CHILDREN AB Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of >= 10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm(3) at or before time of vaccination. Of these, 49% had an HIV RNA load < 1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log(10) HIV RNA levels (beta = -.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses. C1 [Crum-Cianflone, Nancy F.; Wilkins, Kenneth; Landrum, Michael L.; Weintrob, Amy; Ganesan, Anuradha; Maguire, Jason; Brandt, Carolyn; Bradley, William P.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.; Brandt, Carolyn] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92134 USA. [Lee, Andrew W.; Grosso, Anthony; Klopfer, Stephanie] Merck Res Labs, N Wales, PA USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Maguire, Jason] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. [Wallace, Mark R.] Orlando Reg Med Clin, Infect Dis Clin, Orlando, FL USA. RP Crum-Cianflone, NF (reprint author), USN, Clin Invest Dept KCA, San Diego Med Ctr, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU Department of Defense through the Uniformed Services University of the Health Sciences [IDCRP-000-11]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX This work was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences (IDCRP-000-11); and the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Inter-Agency Agreement Y1-AI-5072). NR 43 TC 24 Z9 25 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2011 VL 203 IS 12 BP 1815 EP 1823 DI 10.1093/infdis/jir180 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 770BO UT WOS:000291062200016 PM 21606540 ER PT J AU Juma, WP Akala, HM Eyase, FL Muiva, LM Heydenreich, M Okalebo, FA Gitu, PM Peter, MG Walsh, DS Imbuga, M Yenesew, A AF Juma, Wanyama P. Akala, Hoseah M. Eyase, Fredrick L. Muiva, Lois M. Heydenreich, Matthias Okalebo, Faith A. Gitu, Peter M. Peter, Martin G. Walsh, Douglas S. Imbuga, Mabel Yenesew, Abiy TI Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea SO PHYTOCHEMISTRY LETTERS LA English DT Article DE Tephrosia purpurea; Leguminosae; Stem; Flavone; Terpurinflavone; Antiplasmodial ID PRENYLATED FLAVONOIDS; APOLLINEA; SEED AB The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. C1 [Juma, Wanyama P.; Muiva, Lois M.; Gitu, Peter M.; Yenesew, Abiy] Univ Nairobi, Dept Chem, Nairobi, Kenya. [Akala, Hoseah M.; Eyase, Fredrick L.; Walsh, Douglas S.] USA, Med Res Unit Kenya, APO, AE 09831 USA. [Eyase, Fredrick L.; Imbuga, Mabel] Jomo Kenyatta Univ Agr & Technol, Dept Biochem, Nairobi, Kenya. [Heydenreich, Matthias; Peter, Martin G.] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany. [Okalebo, Faith A.] Univ Nairobi, Sch Pharm, Nairobi, Kenya. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke OI Heydenreich, Matthias/0000-0003-1639-4959 FU Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry for Economic Cooperation and Development (BMZ) within the DFG/BMZ FX We acknowledge the Deutche Forschungemeinschaft (DFG), Germany and the Germany Federal Ministry for Economic Cooperation and Development (BMZ) within the DFG/BMZ Programme "Research Cooperation with Developing Countries'', for supporting the study. Mr. P. C. Mutiso is thanked for the identification of the plant material. NR 17 TC 10 Z9 10 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1874-3900 J9 PHYTOCHEM LETT JI Phytochem. Lett. PD JUN 15 PY 2011 VL 4 IS 2 BP 176 EP 178 DI 10.1016/j.phytol.2011.02.010 PG 3 WC Plant Sciences; Chemistry, Medicinal SC Plant Sciences; Pharmacology & Pharmacy GA 766MV UT WOS:000290788100027 ER PT J AU Lentine, KL Schnitzler, MA Xiao, HL Davis, CL Axelrod, D Abbott, KC Salvalaggio, PR Burroughs, TE Saab, G Brennan, DC AF Lentine, Krista L. Schnitzler, Mark A. Xiao, Huiling Davis, Connie L. Axelrod, David Abbott, Kevin C. Salvalaggio, Paolo R. Burroughs, Thomas E. Saab, Georges Brennan, Daniel C. TI Associations of Recipient Illness History With Hypertension and Diabetes After Living Kidney Donation SO TRANSPLANTATION LA English DT Article DE Diabetes mellitus; Family health history; Hypertension; Kidney transplantation; Living donors ID BLOOD-PRESSURE; MEDICAL OUTCOMES; PARENTAL HISTORY; DONORS; RISK; SUSCEPTIBILITY; METAANALYSIS; MORTALITY; VARIANTS; DISEASE AB Background. Little is known about associations of family health history with outcomes after kidney donation. Methods. Using a database wherein Organ Procurement and Transplantation Network identifiers for 4650 living kidney donors in 1987 to 2007 were linked to administrative data of a US private health insurer (2000-2007 claims), we examined associations of recipient illness history as a measure of family history with postdonation diagnoses and drug-treatment for hypertension and diabetes. Cox regression with left and right censoring was applied to estimate associations (adjusted hazards ratios, aHR) of recipient illness history with postnephrectomy donor diagnoses, stratified by donor-recipient relationship. Results. Recipient end-stage renal disease from hypertension, as compared with other recipient end-stage renal disease causes, was associated with modest, significant increases in the age- and gender-adjusted relative risks of hypertension diagnosis (aHR, 1.37%; 95% confidence interval [CI], 1.08-1.74) after donor nephrectomy among related donors. After adjustment for age, gender, and race, recipient type 2 diabetes compared with non-diabetic recipient status was associated with twice the relative risk of postdonation diabetes (aHR, 2.14; 95% CI, 1.28-3.55; P = 0.003) among related donors. These patterns were significant among white but not among non-white related donors. Recipient type 1 diabetes was associated with postdonation diabetes only in black related donors (aHR, 3.22; 95% CI, 1.04-9.98; P = 0.04). Recipient illness did not correlate significantly with outcomes in unrelated donors. Conclusions. These data support a need for further study of family health history as a potential sociodemographic correlate of donor outcomes, including examination of potential mediating factors and variation in risk discrimination among donors of different racial groups. C1 [Lentine, Krista L.] St Louis Univ, Ctr Outcomes Res, Salus Ctr, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Div Nephrol, Sch Med, St Louis, MO 63104 USA. [Davis, Connie L.] Univ Washington, Kidney & Pancreas Transplant Program, Seattle, WA 98195 USA. [Axelrod, David] Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Saab, Georges; Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Salus Ctr, Sch Med, 4th Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentinek@slu.edu OI Abbott, Kevin/0000-0003-2111-7112 FU National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) [K08DK073036, P30DK079333] FX This work was supported, in part, by the National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) grants K08DK073036 (K.L.L.) and P30DK079333 (M.A.S., D.C.B.). NR 24 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUN 15 PY 2011 VL 91 IS 11 BP 1227 EP 1232 DI 10.1097/TP.0b013e31821a1ae2 PG 6 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 769JN UT WOS:000291008800014 PM 21499197 ER PT J AU Bradfute, SB Stuthman, KS Shurtleff, AC Bavari, S AF Bradfute, Steven B. Stuthman, Kelly S. Shurtleff, Amy C. Bavari, Sina TI A STAT-1 knockout mouse model for Machupo virus pathogenesis SO VIROLOGY JOURNAL LA English DT Article ID BOLIVIAN HEMORRHAGIC-FEVER; I INTERFERON INDUCTION; AFRICAN-GREEN MONKEY; RHESUS-MONKEY; GUINEA-PIGS; INFECTION; PATHOLOGY; MICE; IMMUNOGLOBULIN; ARENAVIRUSES AB Background: Machupo virus (MACV), a member of the Arenaviridae, causes Bolivian hemorrhagic fever, with similar to 20% lethality in humans. The pathogenesis of MACV infection is poorly understood, and there are no clinically proven treatments for disease. This is due, in part, to a paucity of small animal models for MACV infection in which to discover and explore candidate therapeutics. Methods: Mice lacking signal transducer and activator of transcription 1 (STAT-1) were infected with MACV. Lethality, viral replication, metabolic changes, hematology, histopathology, and systemic cytokine expression were analyzed throughout the course of infection. Results: We report here that STAT-1 knockout mice succumbed to MACV infection within 7-8 days, and presented some relevant clinical and histopathological manifestations of disease. Furthermore, the model was used to validate the efficacy of ribavirin in protection against infection. Conclusions: The STAT-1 knockout mouse model can be a useful small animal model for drug testing and preliminary immunological analysis of lethal MACV infection. C1 [Bradfute, Steven B.; Stuthman, Kelly S.; Shurtleff, Amy C.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM sina.bavari@us.army.mil FU Department of Defense through the Defense Threat Reduction Agency (DTRA) [TMTI0039_09_RD_T]; U.S. Army Medical Research Institute for Infectious Disease FX We thank Dr. Sheli Radoshitzky for critical reading of the manuscript, and Dr. Gordon Ruthel for assistance with photomicrographs. This work was supported in part by the Transformational Medical Technologies program (TMTI0039_09_RD_T) (SB) from the Department of Defense Chemical Biological Defense program through the Defense Threat Reduction Agency (DTRA); and supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute for Infectious Disease administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and U. S. Army Medical Research and Materiel Command (S. B. B.). The content of this publication does not necessarily reflect the views or policies of the US Department of Defense or the US Department of the Army. NR 26 TC 21 Z9 21 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUN 14 PY 2011 VL 8 AR 300 DI 10.1186/1743-422X-8-300 PG 8 WC Virology SC Virology GA 785HE UT WOS:000292217400001 PM 21672221 ER PT J AU O'Malley, PG AF O'Malley, Patrick G. TI The Proof of Atherosclerosis Imaging Is in the Evidence Where Are the Studies? SO ARCHIVES OF INTERNAL MEDICINE LA English DT Editorial Material C1 [O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Dept Med EDP, Bethesda, MD 20814 USA. [O'Malley, Patrick G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP O'Malley, PG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med EDP, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM pomalley@usuhs.mil NR 3 TC 4 Z9 4 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JUN 13 PY 2011 VL 171 IS 11 BP 976 EP 976 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 776OB UT WOS:000291544400002 PM 21403013 ER PT J AU Childs, JD Teyhen, DS Van Wyngaarden, JJ Dougherty, BF Ladislas, BJ Helton, GL Robinson, ME Wu, SS George, SZ AF Childs, John D. Teyhen, Deydre S. Van Wyngaarden, Joshua J. Dougherty, Brett F. Ladislas, Bryan J. Helton, Gary L. Robinson, Michael E. Wu, Samuel S. George, Steven Z. TI Predictors of web-based follow-up response in the Prevention of Low Back Pain in the Military Trial (POLM) SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article ID CORE STABILIZATION EXERCISES; RETENTION AB Background: Achieving adequate follow-up in clinical trials is essential to establish the validity of the findings. Achieving adequate response rates reduces bias and increases probability that the findings can be generalized to the population of interest. Therefore, the purpose of this study was to determine the influence of attention, demographic, psychological, and health status factors on web-based response rates in the ongoing Prevention of Low Back Pain in the Military (POLM) trial. Methods: Twenty companies of Soldiers (n = 4,325) were cluster randomized to complete a traditional exercise program including sit-ups (TEP) with or without a psychosocial educational program (PSEP) or a core stabilization exercise program (CSEP) with or without PSEP. A subgroup of Soldiers (n = 371) was randomized to receive an additional physical and ultrasound imaging (USI) examination of key trunk musculature. As part of the surveillance program, all Soldiers were encouraged to complete monthly surveys via email during the first year. Descriptive statistics of the predictor variables were obtained and compared between responders and non-responders using two sample t-tests or chi-square test, as appropriate. Generalized linear mixed models were subsequently fitted for the dichotomous outcomes to estimate the effects of the predictor variables. The significance level was set at .05 a priori. Results: The overall response rate was 18.9% (811 subjects) for the first year. Responders were more likely to be older, Caucasian, have higher levels of education and income, reservist military status, non smoker, lower BMI, and have received individualized attention via the physical/USI examination (p < .05). Age, race/ethnicity, education, military status, smoking history, BMI, and whether a Soldier received the physical/USI examination remained statistically significant (p < .05) when considered in a full multivariate model. Conclusion: The overall web based response rate during the first year of the POLM trial was consistent with studies that used similar methodology, but lower when compared to rates expected for standard clinical trials. One year response rate was significantly associated with demographic characteristics, health status, and individualized attention via additional testing. These data may assist for planning of future trials that use web based response systems. Trial Registration: This study has been registered at reports at http://clinicaltrials.gov (NCT00373009). C1 [Childs, John D.; Teyhen, Deydre S.; Van Wyngaarden, Joshua J.; Dougherty, Brett F.; Ladislas, Bryan J.; Helton, Gary L.] US Army Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Robinson, Michael E.] Univ Florida, Dept Clin & Hlth Psychol, Hlth Sci Ctr, Gainesville, FL 32610 USA. [Wu, Samuel S.] Univ Florida, Dept Biostat, Gainesville, FL 32610 USA. [George, Steven Z.] Univ Florida, Dept Phys Therapy, Ctr Pain Res & Behav Treatment, Gainesville, FL 32610 USA. RP Childs, JD (reprint author), US Army Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, 3151 Scott Rd,Rm 2307, Ft Sam Houston, TX 78234 USA. EM childsjd@gmail.com FU University of Florida; U.S. Army-Baylor University; University of Texas Health Science Center at San Antonio; East Tennessee State University; University of Colorado at Denver and Health Sciences Center; Texas State University; University of Puget FX Various students within the physical therapy programs at the University of Florida, U.S. Army-Baylor University Doctoral Program in Physical Therapy, University of Texas Health Science Center at San Antonio, East Tennessee State University, University of Colorado at Denver and Health Sciences Center, Texas State University, and University of Puget Sound Funding attribution will be acknowledged in the paper using the statement: "Publication of this article was funded in part by the University of Florida Open-Access Publishing Fund." NR 19 TC 8 Z9 8 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD JUN 13 PY 2011 VL 12 AR 132 DI 10.1186/1471-2474-12-132 PG 11 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 785VX UT WOS:000292261500001 PM 21668961 ER PT J AU Arun, P Spadaro, J John, J Gharavi, RB Bentley, TB Nambiar, MP AF Arun, Peethambaran Spadaro, John John, Jennifer Gharavi, Robert B. Bentley, Timothy B. Nambiar, Madhusoodana P. TI Studies on blast traumatic brain injury using in-vitro model with shock tube SO NEUROREPORT LA English DT Article DE biochemical analysis; blast injury; cellular effects; cellular injury; in-vitro model; neurobiological effects; neuropathology; shock tube; traumatic brain injury ID ADULT-RAT BRAIN; LASTING IMPULSE NOISE; CYCLOPHILIN-A; INTRACRANIAL-PRESSURE; INDUCED NEUROTRAUMA; COGNITIVE FUNCTION; CELL-CULTURES; EXPOSURE; OVERPRESSURE; EXPRESSION AB One of the major limitations in studying the mechanisms of blast-induced traumatic brain injury (bTBI) or screening therapeutics for protection is the lack of suitable laboratory model systems that can closely mimic the complex blast exposure. Although animal models of bTBI that use shock tubes to mimic blast exposure are available, no high throughput shock tube-based in-vitro models have been reported. Here, we report an in-vitro bTBI model using a compressed air-driven shock tube and mouse neuroblastoma/rat glioblastoma hybrid cells (NG108-15) or SH-SY5Y human neuroblastoma cells in tissue culture plates. Our data showed significant neurobiological effects with decreased adenosine triphosphate levels, increased cellular injury, lactate dehydrogenase release, and reactive oxygen species formation after blast exposure. NeuroReport 22:379-384 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. C1 [Arun, Peethambaran; Spadaro, John; John, Jennifer; Gharavi, Robert B.; Bentley, Timothy B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@us.army.mil NR 25 TC 26 Z9 26 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD JUN 11 PY 2011 VL 22 IS 8 BP 379 EP 384 DI 10.1097/WNR.0b013e328346b138 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 756SY UT WOS:000290036200004 PM 21532394 ER PT J AU Densmore, JM Biss, MM McNesby, KL Homan, BE AF Densmore, John M. Biss, Matthew M. McNesby, Kevin L. Homan, Barrie E. TI High-speed digital color imaging pyrometry SO APPLIED OPTICS LA English DT Article ID FILTER ARRAY INTERPOLATION; MULTIBAND PYROMETRY; OPTICAL PYROMETRY; TEMPERATURES; DEMOSAICKING; EXPLOSIVES; DESIGN; CAMERA; FLAME AB Temperature measurements of high-explosive and combustion processes are difficult to obtain due to the speed and environment of the events. To overcome these challenges, we have characterized and calibrated a digital high-speed color camera that may be used to measure the temperature of such events. A two-color ratio method is used to calculate a temperature using the color filter array raw image data and a graybody assumption. If the raw image data are not available, temperatures may be calculated from the processed images or movies, depending on proper analysis of the digital color imaging pipeline. We analyze three transformations within the pipeline (demosaicing, white balance, and gamma correction) to determine their effect on the calculated temperature. Using this technique with a Phantom color camera, we have measured the temperature of exploded C-4 charges. The surface temperature of the resulting fireball was found to rapidly increase after detonation, and subsequently decayed to a constant value of approximately 1980 K. C1 [Densmore, John M.; Biss, Matthew M.; McNesby, Kevin L.; Homan, Barrie E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Densmore, JM (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.m.densmore@us.army.mil RI Densmore, John/G-1228-2011; OI Densmore, John/0000-0003-2388-1413; Biss, Matthew/0000-0003-3780-6393 FU U.S. Army Research Laboratory FX This research was supported in part by an appointment to the United States Army Research Laboratory Postdoctoral Fellowship Program, administered by the Oak Ridge Associated Universities and National Research Council through a contract with the U.S. Army Research Laboratory. NR 45 TC 13 Z9 13 U1 2 U2 24 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 2011 VL 50 IS 17 BP 2659 EP 2665 DI 10.1364/AO.50.002659 PG 7 WC Optics SC Optics GA 780QG UT WOS:000291872800021 PM 21673769 ER PT J AU Mehmood, A Nasrabadi, NM AF Mehmood, Asif Nasrabadi, Nasser M. TI Kernel wavelet-Reed-Xiaoli: an anomaly detection for forward-looking infrared imagery SO APPLIED OPTICS LA English DT Article ID AUTOMATIC TARGET RECOGNITION; HYPERSPECTRAL IMAGERY AB This paper describes a new kernel wavelet-based anomaly detection technique for long-wave (LW) forward-looking infrared imagery. The proposed approach called kernel wavelet-Reed-Xiaoli (wavelet-RX) algorithm is essentially an extension of the wavelet-RX algorithm (combination of wavelet transform and RX anomaly detector) to a high-dimensional feature space (possibly infinite) via a certain nonlinear mapping function of the input data. The wavelet-RX algorithm in this high-dimensional feature space can easily be implemented in terms of kernels that implicitly compute dot products in the feature space (kernelizing the wavelet-RX algorithm). In the proposed kernel wavelet-RX algorithm, a two-dimensional wavelet transform is first applied to decompose the input image into uniform subbands. A number of significant subbands (high-energy subbands) are concatenated together to form a subband-image cube. The kernel RX algorithm is then applied to this subband-image cube. Experimental results are presented for the proposed kernel wavelet-RX, wavelet-RX, and the classical constant false alarm rate (CFAR) algorithm for detecting anomalies (targets) in a large database of LW imagery. The receiver operating characteristic plots show that the proposed kernel wavelet-RX algorithm outperforms the wavelet-RX as well as the classical CFAR detector. (C) 2011 Optical Society of America C1 [Mehmood, Asif; Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1@us.army.mil NR 23 TC 2 Z9 2 U1 1 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 2011 VL 50 IS 17 BP 2744 EP 2751 DI 10.1364/AO.50.002744 PG 8 WC Optics SC Optics GA 780QG UT WOS:000291872800032 PM 21673780 ER PT J AU Geary, JR Nijak, GM Larson, SL Talley, JW AF Geary, Joseph R. Nijak, Gary M., Jr. Larson, Steven L. Talley, Jeffrey W. TI Hydrolysis of the soluble fluorescent molecule carboxyumbelliferyl-beta-D-glucuronide by E. coli beta-glucuronidase as applied in a rugged, in situ optical sensor SO ENZYME AND MICROBIAL TECHNOLOGY LA English DT Article DE Glucuronidase; E. coli; Fluorophore; Enzyme; Sensor ID ESCHERICHIA-COLI; FRESH-WATERS; ASSAY; CATALYSIS; ACIDS AB Techniques utilizing beta-glucuronidase (GUS) activity as an indicator of Escherichia coli (E. coli) presence use labeled glucuronides to produce optical signals. Carboxyumbelliferyl-beta-D-glucuronide (CUGIcU) is a fluorescent labeled glucuronide that is soluble and highly fluorescent at natural water pHs and temperatures and, therefore, may be an ideal reagent for use in an in situ optical sensor. This paper reports for the first time the Michaelis-Menten kinetic parameters for the binding of E. coli GUS with CUGIcU as K-m = 910 mu M, V-max = 41.0 mu M min(-1), V-max/K-m 45.0 mu mol L-1 min(-1), the optimal pH as 6.5 +/- 1.0, optimal temperature as 38 degrees C, and the Gibb's free energy of activation as 61.40 kJ mol(-1). Additionally, it was found CUGIcU hydrolysis is not significantly affected by heavy solvents suggesting proton transfer and solvent addition that occur during hydrolysis are not limiting steps. Comparison studies were made with the more common fluorescent molecule methylumbelliferyl-beta-D-glucuronide (MUGIcU). Experiments showed GUS preferentially binds to MUGIcU in comparison to CUGIcU. CUGIcU was also demonstrated in a prototype optical sensor for the detection of E. coli. Initial bench testing of the sensor produced detection of low concentrations of E. coli (1.00 x 10(3) CFU/100 mL) in 230 +/- 15.1 min and high concentrations (1.05 x 10(5) CFU/100 mL) in 8.00 +/- 1.01 min. (C) 2011 Elsevier Inc. All rights reserved. C1 [Geary, Joseph R.; Nijak, Gary M., Jr.; Talley, Jeffrey W.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Larson, Steven L.] USA, Corps Engineers, Waterways Expt Stn, Environm Chem Branch, Vicksburg, MS 39180 USA. RP Talley, JW (reprint author), Environm Technol Solut LLC, 75W Baseline Rd STE 32, Gilbert, AZ 85233 USA. EM jtalley@etspartners.com FU CRANE Naval Surface Warfare Center from Defense Advanced Research Product's Agency [N00164-07-C-8510] FX This work was supported by CRANE Naval Surface Warfare Center grant #N00164-07-C-8510 from the Defense Advanced Research Product's Agency. NR 24 TC 5 Z9 5 U1 3 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0141-0229 EI 1879-0909 J9 ENZYME MICROB TECH JI Enzyme Microb. Technol. PD JUN 10 PY 2011 VL 49 IS 1 BP 6 EP 10 DI 10.1016/j.enzmictec.2011.03.009 PG 5 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 785LW UT WOS:000292231500002 PM 22112264 ER PT J AU Doi, M Tanabe, K Tachibana, SL Hamai, M Tachibana, M Mita, T Yagi, M Zeyrek, FY Ferreira, MU Ohmae, H Kaneko, A Randrianarivelojosia, M Sattabongkot, J Cao, YM Horii, T Torii, M Tsuboi, T AF Doi, Masanori Tanabe, Kazuyuki Tachibana, Shin-Lchiro Hamai, Meiko Tachibana, Mayumi Mita, Toshihiro Yagi, Masanori Zeyrek, Fadile Yildiz Ferreira, Marcelo U. Ohmae, Hiroshi Kaneko, Akira Randrianarivelojosia, Milijaona Sattabongkot, Jetsumon Cao, Ya-Ming Horii, Toshihiro Torii, Motomi Tsuboi, Takafumi TI Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax SO VACCINE LA English DT Article DE Malaria; Plasmodium vivax; Pvs230; Gametocyte surface antigen; Purifying selection; Transmission-blocking vaccine ID GAMETE-SURFACE PROTEIN; SIMIAN MALARIA PARASITES; TARGET ANTIGEN; POPULATION-STRUCTURE; ANTIBODY-RESPONSES; GENETIC DIVERSITY; DNA POLYMORPHISM; RURAL AMAZONIA; FALCIPARUM; PFS230 AB Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whether Pvs230 can be a vivax malaria transmission-blocking vaccine, we performed evolutionary and population genetic analysis of the Pvs230 gene (pvs230: PVX_003905). Our analysis of Pvs230 and its orthologs in eight Plasmodium species revealed two distinctive parts: an interspecies variable part (IVP) containing species-specific oligopeptide repeats at the N-terminus and a 7.5 kb interspecies conserved part (ICP) containing 14 cysteine-rich domains. Pvs230 was closely related to its orthologs, Pks230 and Pcys230, in monkey malaria parasites. Analysis of 113 pvs230 sequences obtained from worldwide, showed that nucleotide diversity is remarkably low in the non-repeat 8-kb region of pvs230 (theta pi = 0.00118) with 77 polymorphic nucleotide sites, 40 of which results in amino acid replacements. A signature of purifying selection but not of balancing selection was seen on pvs230. Functional and/or structural constraints may limit the level of polymorphism in pvs230. The observed limited polymorphism in pvs230 should ground for utilization of Pvs230 as an effective transmission-blocking vaccine. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Doi, Masanori; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Tanabe, Kazuyuki; Tachibana, Shin-Lchiro] Osaka Univ, Microbial Dis Res Inst, Lab Malariol, Suita, Osaka 5650871, Japan. [Hamai, Meiko; Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Dept Mol Parasitol, Grad Sch Med, Toon, Ehime 7910295, Japan. [Mita, Toshihiro] Tokyo Womens Med Univ, Dept Int Affairs & Trop Med, Tokyo 1628666, Japan. [Yagi, Masanori; Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 5650871, Japan. [Zeyrek, Fadile Yildiz] Harran Univ, Fac Med, Dept Microbiol, Sanliurfa, Turkey. [Ferreira, Marcelo U.] Univ Sao Paulo, Dept Parasitol, Inst Biomed Sci, Sao Paulo, Brazil. [Ohmae, Hiroshi] Natl Inst Infect Dis, Dept Parasitol, Tokyo, Japan. [Kaneko, Akira] Karolinska Inst, Isl Malaria Grp, Dept Microbiol Timor & Cell Biol, S-17177 Stockholm, Sweden. [Kaneko, Akira] Nagasaki Univ, Global COE, Inst Trop Med, Nagasaki 852, Japan. [Randrianarivelojosia, Milijaona] Inst Pasteur Madagascar, Unite Rech Paludisme, Antananarivo, Madagascar. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Cao, Ya-Ming] China Med Univ, Dept Immunol, Coll Basic Med Sci, Shenyang 110001, Peoples R China. [Torii, Motomi; Tsuboi, Takafumi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp RI Ferreira, Marcelo/G-8289-2011; OI Ferreira, Marcelo/0000-0002-5293-9090; , Akira/0000-0003-2411-3352 FU Ministry of Education, Culture, Sports, Science and Technology [18073013, 18GS03140013, 20390120, 19406009, 21022034, 22406012]; Ministry of Health, Labour, and Welfare, Japan [H20-Shinkou-ippan-013, H21-Chikyukibo-ippan-005]; Japan Society for the Promotion of Science; National Institutes of Health of USA [RO1 AI 075416-01]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [470570/2006-7]; Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) [05/51988-0, 07/51199-0]; National Natural Science Foundation of China [30972774] FX We thank all those who participated in the epidemiological studies for their kind cooperation, particularly T. Tsukahara, F. Hombhanje, Fehmi Yuksel, Nebiye Doni, and B. Bakote'e. We also thank Thangavelu U. Arumugam for the critical reading of the manuscript. This research was supported by the Ministry of Education, Culture, Sports, Science and Technology (18073013, 18GS03140013, 20390120, 19406009, 21022034, 22406012), and by the Ministry of Health, Labour, and Welfare, Japan (H20-Shinkou-ippan-013, H21-Chikyukibo-ippan-005) and by Japan Society for the Promotion of Science Fellowship Program (to FYZ). Field work in Brazil was funded by the National Institutes of Health of USA (RO1 AI 075416-01), the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, 470570/2006-7), and the Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP, 05/51988-0 and 07/51199-0). This work was also supported by grant from the National Natural Science Foundation of China (30972774). NR 73 TC 18 Z9 19 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 10 PY 2011 VL 29 IS 26 BP 4308 EP 4315 DI 10.1016/j.vaccine.2011.04.028 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 787CG UT WOS:000292353600003 PM 21514344 ER PT J AU Convertino, M AF Convertino, M. TI Neutral metacommunity clustering and SAR: River basin vs. 2-D landscape biodiversity patterns SO ECOLOGICAL MODELLING LA English DT Article DE Species Clustering; Trees; Fishes; Neutral metacommunity model; Biodiversity; Mississippi-Missouri River System; Dispersal ID SPECIES-AREA RELATIONSHIPS; SPATIAL AGGREGATION; SIZE DISTRIBUTIONS; TROPICAL FORESTS; DISPERSAL; MODEL; LAW; CRITICALITY; POPULATION; ECOSYSTEMS AB Moving from the analysis of the spatial distribution of fishes and big/small trees of the Mississippi Missouri River System, I evidenced and modeled with a neutral metacommunity model the power-law exceedence probability of the cluster-size of species and the species-area relationship (SAR). The slopes of the power-law distribution of the cluster-size P(CS >= c) and of the SAR vary for each taxi and life-stages underlying different spatial organization. A clear relationship exists between the slope z of the SAR and the slope 6 of P(CS >= c), that is dependent on the ecosystem topology and shape, and on the dispersal kernel function. The heterogeneity of the environmental features leads to the formation of smaller clusters than in the ideal homogeneous scenario. P(CS >= cs) declines to an exponential distribution in dispersal-limited scenarios for which the effect of the environmental heterogeneities is stronger, the probability distribution of the local and pairwise species richness similarity is a lognormal function and the occupancy-rank is concave upward. The clustering of species has been studied on other real and artificial river networks and on 2-D non-fragmented landscapes. River networks have smaller clusters than 2-D landscapes for the same ecological dispersal scenario however the range in which P(CS >= c) holds is larger. The higher the elongation of the ecosystem the bigger the LSR, and the smaller the mean cluster-size. River networks due to the larger link-diameter than 2-D landscapes with the same domain are potentially more robust ecosystems, for example against invasion of invasive/exotic species and pathogens. The ecological ratio between the mean dispersal parameter and the average diameter is introduced as useful tool to compare biodiversity patterns. The influence of the dendritic structure of the river network has been reinforced. Nonetheless P(CS >= c), is found not invariant across different scales, and coarse-graining levels of the ecosystems. The study enhances the robustness of the stochastic birth-depth process in shaping biodiversity patterns, however I underline the strong influence of the dispersal parameter in the assemblage of species. The understanding of the relative influence of exogenous and endogenous variables is important to detect climatic and anthropic effects on the cluster-size distribution of species. (E) 2011 Elsevier B.V. All rights reserved. C1 [Convertino, M.] Univ Florida, IFAS, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Convertino, M.] Risk Modeling & Decis Sci Area, USACE Engn Res & Dev Ctr ERDC, Concord, MA USA. RP Convertino, M (reprint author), Univ Florida, IFAS, Dept Agr & Biol Engn, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu FU Ing; Aldo Gini Foundation; Universita di Padova; NSF [0642517] FX M.C. gratefully acknowledges the support provided by the Ing. Aldo Gini Foundation Fellowship 2008 for research and studies abroad, Universita di Padova, and NSF Award 0642517 "Co-Organization of River Basin Geomorphology and VegetationOO supporting him at the Civil & Environmental Engineering Department, Princeton University. The author acknowledges Rachata Muneepeerakul (Arizona State University), Sandro Azaele (University of Leeds), and Megan Konar (Princeton University) for their support in writing the manuscript and for the useful discussion about this research topic and the model. Ignacio Rodriguez-Iturbe and Andrea Rinaldo are also kindly acknowledged for their support and dedicated enthusiasm during my research period at Princeton University and at the University of Padova. M.C. kindly acknowledges Yanhua Deng for her support during this study. The research was carried out when M.C., R.M. and S.A. were at the Civil & Environmental Engineering Department in the research group of Prof. I. Rodriguez-Iturbe. NR 72 TC 5 Z9 5 U1 0 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD JUN 10 PY 2011 VL 222 IS 11 BP 1863 EP 1879 DI 10.1016/j.ecolmodel.2011.03.015 PG 17 WC Ecology SC Environmental Sciences & Ecology GA 767EZ UT WOS:000290839400008 ER PT J AU Tsang, A Seidle, H Jawaid, S Zhou, WD Smith, C Couch, RD AF Tsang, Arthur Seidle, Heather Jawaid, Safdar Zhou, Weidong Smith, Clint Couch, Robin D. TI Francisella tularensis 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase: Kinetic Characterization and Phosphoregulation SO PLOS ONE LA English DT Article ID HIGHER-PLANT CHLOROPLASTS; ISOPRENOID BIOSYNTHESIS; ESCHERICHIA-COLI; NONMEVALONATE PATHWAY; 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL; MEVALONATE PATHWAY; PHOSPHATE-PATHWAY; DRUG DEVELOPMENT; MEP SYNTHASE; LYTB PROTEIN AB Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continued development of novel antimicrobial/antiviral therapeutics. Isoprenes, a group of molecules fundamentally involved in a variety of crucial biological functions, are derived from either the mevalonic acid (MVA) or methylerythritol phosphate (MEP) pathway. While mammals utilize the MVA pathway, many bacteria utilize the MEP pathway, highlighting the latter as an attractive target for antibiotic development. In this report we describe the cloning and characterization of Francisella tularensis MEP cytidylyltransferase, a MEP pathway enzyme and potential target for antibiotic development. Size exclusion chromatography indicates the protein exists as a dimer in solution. Enzyme assays produced an apparent K(M)(MEP) = 178 mu M, K(M)(CTP) = 73 mu M, k(cat)(MEP) = 1 s(-1), k(cat)(CTP) = 0.8 s(-1), and a k(cat)(MEP)/K(M)(MEP) = 3.4 x 10(5) M(-1) min(-1). The enzyme exhibits a strict preference for Mg(+2) as a divalent cation and CTP as the nucleotide. Titanium dioxide chromatography-tandem mass spectrometry identified Thr141 as a site of phosphorylation. T141D and T141E site-directed mutants are catalytically inactive, suggesting a mechanism for post-translational control of metabolic flux through the F. tularensis MEP pathway. Overall, our study suggests that MEP cytidylyltransferase is an excellent target for the development of novel antibiotics against F. tularensis. C1 [Tsang, Arthur; Seidle, Heather; Jawaid, Safdar; Couch, Robin D.] George Mason Univ, Dept Chem & Biochem, Manassas, VA 20110 USA. [Tsang, Arthur; Seidle, Heather; Jawaid, Safdar; Couch, Robin D.] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. [Zhou, Weidong] George Mason Univ, Dept Mol & Microbiol, Manassas, VA USA. [Zhou, Weidong] George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA USA. [Smith, Clint] USA, Geospatial Res & Engn Div, Engn Res & Dev Ctr, Alexandria, VA USA. RP Tsang, A (reprint author), George Mason Univ, Dept Chem & Biochem, Manassas, VA 20110 USA. EM rcouch@gmu.edu RI JAWAID, SAFDAR/C-1444-2013 FU George Mason University FX This work was supported by startup funds provided by George Mason University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 8 Z9 10 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 9 PY 2011 VL 6 IS 6 AR e20884 DI 10.1371/journal.pone.0020884 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 777JX UT WOS:000291612900034 PM 21694781 ER PT J AU Han, XF Soblosky, L Slutsky, M Mello, CM Chen, Z AF Han, Xiaofeng Soblosky, Lauren Slutsky, Morris Mello, Charlene M. Chen, Zhan TI Solvent Effect and Time-Dependent Behavior of C-Terminus-Cysteine-Modified Cecropin P1 Chemically Immobilized on a Polymer Surface SO LANGMUIR LA English DT Article ID SUM-FREQUENCY GENERATION; NONLINEAR-OPTICAL SPECTROSCOPY; QUARTZ-CRYSTAL MICROBALANCE; SCANNING FORCE MICROSCOPY; BETA-SHEET STRUCTURES; PROTEINS IN-SITU; VIBRATIONAL SPECTROSCOPY; ANTIMICROBIAL PEPTIDES; ESCHERICHIA-COLI; ORIENTATION DETERMINATION AB Sum frequency generation (SFG) vibrational spectroscopy has been applied to the investigation of peptide immobilization on a polymer surface as a function of time and peptide conformation. Surface immobilization of biological molecules is important in many applications such as biosensors, antimicrobial materials, biobased fuel cells, nanofabrication, and multifunctional materials. Using C-terminus-cysteine-modified cecropin PI (CP1c) as a model, we investigated the time-dependent immobilization behavior in situ in real time. In addition, potassium phosphate buffer (PB) and trifluoroethanol were utilized to examine the effect of peptide secondary structure on CP1c immobilization to polystyrene maleimide (PS-MA). The orientation of immobilized CP1c on PS-MA was determined using polarized SFG spectra. It was found that the peptide solution concentration, solvent composition, and assembly state (monomer vs dimer) prior to immobilization all influence the orientation of CP1c on a PS-MA surface. The detailed relationship between the interfacial peptide orientation and these immobilization conditions is discussed. C1 [Slutsky, Morris; Mello, Charlene M.] USA, Biosci & Technol Team, Natick Soldier Res Dev & Engn Ctr NSRDEC, Natick, MA 01760 USA. [Han, Xiaofeng; Soblosky, Lauren; Chen, Zhan] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA. RP Mello, CM (reprint author), USA, Biosci & Technol Team, Natick Soldier Res Dev & Engn Ctr NSRDEC, Natick, MA 01760 USA. EM charlene.mello@us.army.mil; zhanc@umich.edu RI Chen, Zhan/G-8312-2016 OI Chen, Zhan/0000-0001-8687-8348 FU U.S. Army Natick Soldier Center [W911QY-10-C-0001]; National Institute of Health [1R01GM081655-01A2] FX This research is supported by the U.S. Army Natick Soldier Center (W911QY-10-C-0001) and the National Institute of Health (1R01GM081655-01A2) NR 71 TC 28 Z9 28 U1 2 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUN 7 PY 2011 VL 27 IS 11 BP 7042 EP 7051 DI 10.1021/la200388y PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 768ZF UT WOS:000290978100062 PM 21553837 ER PT J AU Katz, JD Mamyrova, G Agarwal, S Jones, OY Bollar, H Huber, AM Rider, LG White, PH AF Katz, James D. Mamyrova, Gulnara Agarwal, Shilpi Jones, Olcay Y. Bollar, Harriet Huber, Adam M. Rider, Lisa G. White, Patience H. TI Parents' perception of self-advocacy of children with myositis: an anonymous online survey SO PEDIATRIC RHEUMATOLOGY LA English DT Article ID ADULT CARE; HEALTH-CARE; TRANSITION; ADOLESCENTS; ILLNESS; PATIENT; DISEASE AB Background: Children with complex medical issues experience barriers to the transition of care from pediatric to adult providers. We sought to identify these barriers by elucidating the experiences of patients with idiopathic inflammatory muscle disorders. Methods: We collected anonymous survey data using an online website. Patients and their families were solicited from the US and Canada through established clinics for children with idiopathic inflammatory muscle diseases as well as with the aid of a nonprofit organization for the benefit of such individuals. The parents of 45 older children/young adults suffering from idiopathic inflammatory muscle diseases were surveyed. As a basis of comparison, we similarly collected data from the parents of 207 younger children with inflammatory muscle diseases. The survey assessed transition of care issues confronting families of children and young adults with chronic juvenile myositis. Results: Regardless of age of the patient, respondents were unlikely to have a designated health care provider assigned to aid in transition of care and were unlikely to be aware of a posted policy concerning transition of care at their pediatrician's office. Additionally, regardless of age, patients and their families were unlikely to have a written plan for moving to adult care. Conclusions: We identified deficiencies in the health care experiences of families as pertain to knowledge, self-advocacy, policy, and vocational readiness. Moreover, as children with complex medical issues grow up, parents attribute less self-advocacy to their children's level of independence. C1 [Katz, James D.; Mamyrova, Gulnara; White, Patience H.] George Washington Univ, Div Rheumatol, Washington, DC 20052 USA. [Rider, Lisa G.] NIEHS, NIH, Bethesda, MD 20892 USA. [Jones, Olcay Y.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Huber, Adam M.] Dalhousie Univ, Halifax, NS B3H 4R2, Canada. [Huber, Adam M.] IWK Hlth Ctr, Halifax, NS B3H 4R2, Canada. [Agarwal, Shilpi] Glendale Adventist Family Med Residency, Glendale, CA 91205 USA. [Bollar, Harriet] Cure JM, Wilmette, IL 60091 USA. RP Katz, JD (reprint author), George Washington Univ, Div Rheumatol, Washington, DC 20052 USA. EM jkatz@mfa.gwu.edu OI Rider, Lisa/0000-0002-6912-2458 NR 20 TC 2 Z9 2 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1546-0096 J9 PEDIATR RHEUMATOL JI Pediatr. Rheumatol. PD JUN 7 PY 2011 VL 9 AR 10 DI 10.1186/1546-0096-9-10 PG 6 WC Pediatrics; Rheumatology SC Pediatrics; Rheumatology GA 780PQ UT WOS:000291871000001 PM 21649897 ER PT J AU Greenman, JV Pasour, VB AF Greenman, J. V. Pasour, V. B. TI Phase control of resonant systems: Interference, chaos and high periodicity SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article DE Eco-epidemiological models; Epidemic suppression; Subharmonics; Noise excitation; Dengue fever ID TIME POPULATION-MODELS; EPIDEMIOLOGIC SYSTEMS; WILDLIFE DISEASE; DYNAMICS; IMMUNITY; SEASONALITY; PERSISTENCE; ENVIRONMENT; THRESHOLD; PATTERN AB Much progress has been made in understanding the effect of periodic forcing on epidemiological and ecological systems when that forcing acts on just one part of the system. Much less is known about situations in which several parts of the system are affected. In this case the interaction between the impacts of the different forcing components can lead to reinforcement of system responses or to their interference. This interference phenomenon is significant if some forcing components are anthropogenic for then management might be able to exercise sufficient control to bring about suppression of undesirable aspects of the forcing, for example resonant amplification and the problems this can cause. We set out the algebraic theory when forcing is weak and illustrate by example what can happen when forcing is strong enough to create subharmonics and chaotic states. Phase is the key control variable that can bring about interference, advantageously shift nonlinear response curves and create periodic states out of chaos. The phenomenon in which high period fluctuations appear to be generated by low period forcing is examined and different mechanisms compared in a two-strain epidemiological model. The effect of noise as a source of high period fluctuations is also considered. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Greenman, J. V.] Univ Stirling, Dept Comp Sci & Math, Stirling FK9 4LA, Scotland. [Pasour, V. B.] USA, Res Off, Div Math Sci, Durham, NC USA. RP Greenman, JV (reprint author), Univ Stirling, Dept Comp Sci & Math, Stirling FK9 4LA, Scotland. EM j.v.greenman@stir.ac.uk; virginia.pasour@us.army.mil NR 37 TC 4 Z9 5 U1 1 U2 8 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-5193 J9 J THEOR BIOL JI J. Theor. Biol. PD JUN 7 PY 2011 VL 278 IS 1 BP 74 EP 86 DI 10.1016/j.jtbi.2011.03.002 PG 13 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 754CK UT WOS:000289829500008 PM 21397609 ER PT J AU Rerks-Ngarm, S Premsri, N Namwat, C Khamboonruang, C Kunasol, P Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Eamsila, C Benenson, MW Paris, R Kim, JH Chunsuttiwat, S Thongcharoen, P Bussaratid, V Maek-a-Nantawat, W Dhitavat, J Suntharasamai, P Pungpak, S Vanijanonta, S Khamsiriwatchara, A Jarujareet, P Tabprasit, S Morgan, P de Souza, M Brown, AE Trichavaroj, R Gurunathan, S Tartaglia, J McNeil, JG Francis, D Heyward, W Gurwith, M Chiu, J Robb, ML Michael, NL Birx, DL Milazzo, M Bolen, A AF Rerks-Ngarm, Supachai Premsri, Nakorn Namwat, Chawetsan Khamboonruang, Chirasak Kunasol, Prayura Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Eamsila, Chirapa Benenson, Michael W. Paris, Robert Kim, Jerome H. Chunsuttiwat, Supamit Thongcharoen, Prasert Bussaratid, Valai Maek-a-Nantawat, Wirach Dhitavat, Jittima Suntharasamai, Pravan Pungpak, Swangjai Vanijanonta, Sirivan Khamsiriwatchara, Amnat Jarujareet, Pawinee Tabprasit, Sutchana Morgan, Patricia de Souza, Mark Brown, Arthur E. Trichavaroj, Rapee Gurunathan, Sanjay Tartaglia, Jim McNeil, John G. Francis, Donald Heyward, William Gurwith, Marc Chiu, Joseph Robb, Merlin L. Michael, Nelson L. Birx, Deborah L. Milazzo, Mark Bolen, Aimee CA Minist Public Hlth-Thai Aids Vacci TI Screening and evaluation of potential volunteers for a phase III trial in Thailand of a candidate preventive HIV vaccine (RV148) SO VACCINE LA English DT Article DE HIV-1; Vaccine trial; Thailand; Screening; Phase III; Prime-boost; ALVAC-HIV; AIDSVAX; gp120; RV144; RV148 ID IMMUNODEFICIENCY-VIRUS TYPE-1; SUBTYPE-E; RISK-FACTORS; DOUBLE-BLIND; INFECTION; IMMUNOGENICITY; EFFICACY; SAFETY; PRIME; BOOST AB Screening for the community-based, phase III, prime-boost HIV vaccine trial conducted in Thailand (also referred to as "RV144") began in September 2003 and concluded in December 2005 in Rayong and Chon Buri provinces. During this period 26,676 persons were consented and screened for vaccine trial eligibility in a separate protocol ("RV148") at 47 screening sites, of which 26,548 were tested for HIV, and 16,402 were ultimately enrolled in RV144 and received at least one vaccination or corresponding placebo injection. Fifty-eight percent of those enrolled in RV148 were men and roughly half of the men and women were married. A slight majority was born in the provinces in which the study was conducted. The median age was 23 (IQR 20-26) and most had achieved a level of education that was higher than grade 9, which is compulsory for Thai citizens. The prevalence of confirmed HIV infection was 1.6%; among persons who did not return for confirmatory testing, it was 2.0%. Eighty-three percent were infected with CRF01 AE strains (formerly subtype E) as determined by serological typing. The estimated incidence of HIV infection using a capture EIA assay was 0.19 per 100 person-years. Female sex, older age, single marital status, and lower educational attainment were associated with HIV infection. Persons who reported working in the fishing or sex-work industries were more frequently infected (2.4% and 4.1%, respectively), but accounted for a small percent of the tested population in RV148 (0.7% and 0.6%, respectively), reflecting the overall low-risk of HIV in this study. Those screened for eligibility but did not participate in the vaccine trial were not substantially different from enrolled vaccine trial subjects. Published by Elsevier Ltd. C1 [Rerks-Ngarm, Supachai; Premsri, Nakorn; Namwat, Chawetsan; Khamboonruang, Chirasak; Kunasol, Prayura; Chunsuttiwat, Supamit; Thongcharoen, Prasert] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Pitisuttithum, Punnee; Bussaratid, Valai; Maek-a-Nantawat, Wirach; Dhitavat, Jittima; Suntharasamai, Pravan; Pungpak, Swangjai; Vanijanonta, Sirivan] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok, Thailand. [Kaewkungwal, Jaranit; Khamsiriwatchara, Amnat; Jarujareet, Pawinee] Mahidol Univ, Fac Trop Med, Data Management Unit, Bangkok, Thailand. [Nitayaphan, Sorachai; Eamsila, Chirapa; Tabprasit, Sutchana] Royal Thai Army, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Benenson, Michael W.; Paris, Robert; Morgan, Patricia; de Souza, Mark; Brown, Arthur E.; Trichavaroj, Rapee] US Army Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Gurunathan, Sanjay; Tartaglia, Jim; McNeil, John G.] Sanofi Pasteur, Swiftwater, PA USA. [Francis, Donald; Heyward, William; Gurwith, Marc] Global Solut Infect Dis, San Francisco, CA USA. [Chiu, Joseph] NIAID, Div Aids, Bethesda, MD 20892 USA. [Kim, Jerome H.; Robb, Merlin L.; Michael, Nelson L.; Birx, Deborah L.; Milazzo, Mark; Bolen, Aimee] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD USA. [Kim, Jerome H.; Robb, Merlin L.; Michael, Nelson L.; Birx, Deborah L.; Milazzo, Mark; Bolen, Aimee] USA, Med Mat Dev Agcy, USAMRMC, Rockville, MD USA. FU USAMRMC [DAMD-W81XWH-07-2-0067, Y1-AI-5026-01/MRMC 05-0005]; Henry M. Jackson Foundation for the Advancement of Military Medicine [DAMD-W81XWH-07-2-0067]; Division of AIDS, National Institute of Allergy and Infectious Diseases FX This work is supported by DAMD-W81XWH-07-2-0067 between USAMRMC and the Henry M. Jackson Foundation for the Advancement of Military Medicine.; Funding for this work has also been provided by the Division of AIDS, National Institute of Allergy and Infectious Diseases and USAMRMC through an interagency agreement Y1-AI-5026-01/MRMC 05-0005. NR 26 TC 6 Z9 6 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 6 PY 2011 VL 29 IS 25 BP 4285 EP 4292 DI 10.1016/j.vaccine.2011.03.014 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 779KY UT WOS:000291777700018 ER PT J AU Dow, GS Milner, E Bathurst, I Bhonsle, J Caridha, D Gardner, S Gerena, L Kozar, M Lanteri, C Mannila, A McCalmont, W Moon, J Read, KD Norval, S Roncal, N Shackleford, DM Sousa, J Steuten, J White, KL Zeng, Q Charman, SA AF Dow, Geoffrey S. Milner, Erin Bathurst, Ian Bhonsle, Jayendra Caridha, Diana Gardner, Sean Gerena, Lucia Kozar, Michael Lanteri, Charlotte Mannila, Anne McCalmont, William Moon, Jay Read, Kevin D. Norval, Suzanne Roncal, Norma Shackleford, David M. Sousa, Jason Steuten, Jessica White, Karen L. Zeng, Qiang Charman, Susan A. TI Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice SO MALARIA JOURNAL LA English DT Article ID DRUG; ANTIMALARIALS; PERMEABILITY; BILAYERS; BRAIN AB Background: The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early lead chemotype was identified for further optimization. Experimental design: The plasma and brain levels of MQ and twenty five, 4-position modified NGQMs were determined using LCMS/MS at 5 min, 1, 6 and 24 h after IV administration (5 mg/kg) to male FVB mice. Fraction unbound in brain tissue homogenate was assessed in vitro using equilibrium dialysis and this was then used to calculate brain-unbound concentration from the measured brain total concentration. A five-fold reduction CNS levels relative to mefloquine was considered acceptable. Additional pharmacological properties such as permeability and potency were determined. Results: The maximum brain (whole/free) concentrations of MQ were 1807/4.9 ng/g. Maximum whole brain concentrations of NGQMs were 23-21546 ng/g. Maximum free brain concentrations were 0.5 to 267 ng/g. Seven (28%) and two (8%) compounds exhibited acceptable whole and free brain concentrations, respectively. Optimization of maximum free brain levels, IC90s (as a measure or potency) and residual plasma concentrations at 24 h (as a surrogate for half-life) in the same molecule may be feasible since they were not correlated. Diamine quinoline methanols were the most promising lead compounds. Conclusion: Reduction of CNS levels of NGQMs relative to mefloquine may be feasible. Optimization of this property together with potency and long half-life may be feasible amongst diamine quinoline methanols. C1 [Dow, Geoffrey S.; Milner, Erin; Bhonsle, Jayendra; Caridha, Diana; Gardner, Sean; Gerena, Lucia; Kozar, Michael; Lanteri, Charlotte; McCalmont, William; Moon, Jay; Roncal, Norma; Sousa, Jason; Zeng, Qiang] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Bathurst, Ian] Int Ctr Cointrin, CH-1215 Geneva 15, Switzerland. [Mannila, Anne; Shackleford, David M.; Steuten, Jessica; White, Karen L.; Charman, Susan A.] Monash Univ, Ctr Drug Candidate Optimisat, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia. [Read, Kevin D.; Norval, Suzanne] Univ Dundee, Sir James Black Ctr, Div Biol Chem & Drug Discovery, Coll Life Sci, Dundee DD1 5EH, Scotland. RP Dow, GS (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM geoffrey.dow@us.army.mil RI Charman, Susan/E-2221-2011; Sousa, Jason/A-9177-2011 OI Charman, Susan/0000-0003-1753-8213; FU Medicines for Malaria Venture; United States Military Infectious Diseases Research Program; Absorption Systems (Exton PA) FX We gratefully acknowledge Medicines for Malaria Venture and the United States Military Infectious Diseases Research Program for financial support. The MDCK permeability assays were performed under contract by Absorption Systems (Exton PA). We thank Meng Shi for statistical advice. NR 19 TC 13 Z9 13 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 6 PY 2011 VL 10 AR 150 DI 10.1186/1475-2875-10-150 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 786PH UT WOS:000292319900001 PM 21645370 ER PT J AU Koku, H Maier, RS Czymmek, KJ Schure, MR Lenhoff, AM AF Koku, Harun Maier, Robert S. Czymmek, Kirk J. Schure, Mark R. Lenhoff, Abraham M. TI Modeling of flow in a polymeric chromatographic monolith SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Monolith; CIM disk; Scanning electron microscopy; Lattice-Boltzmann; Simulation; Flow field; Permeability ID LATTICE BOLTZMANN METHOD; PHASE LIQUID-CHROMATOGRAPHY; MASS-TRANSFER KINETICS; INTRAPARTICLE-FORCED-CONVECTION; POROUS SILICA COLUMNS; PORE-SCALE FLOW; PACKED-BEDS; PRESSURE-DROP; STATIONARY PHASES; POLYMETHACRYLATE MONOLITHS AB The flow behavior of a commercial polymeric monolith was investigated by direct numerical simulations employing the lattice-Boltzmann (LB) methodology. An explicit structural representation of the monolith was obtained by serial sectioning of a portion of the monolith and imaging by scanning electron microscopy. After image processing, the three-dimensional structure of a sample block with dimensions of 17.8 mu m x 17.8 mu m x 14.1 mu m was obtained, with uniform 18.5 nm voxel size. Flow was simulated on this reconstructed block using the LB method to obtain the velocity distribution, and in turn macroscopic flow properties such as the permeability and the average velocity. The computed axial velocity distribution exhibits a sharp peak with an exponentially decaying tail. Analysis of the local components of the flow field suggests that flow is not evenly distributed throughout the sample geometry, as is also seen in geometries that exhibit preferential flow paths, such as sphere pack arrays with defects. A significant fraction of negative axial velocities are observed; the largest of these are due to flow along horizontal pores that are also slightly oriented in the negative axial direction. Possible implications for mass transfer are discussed. (C) 2011 Elsevier B.V. All rights reserved. C1 [Koku, Harun; Lenhoff, Abraham M.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. [Maier, Robert S.] USA, Army Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. [Czymmek, Kirk J.] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA. [Schure, Mark R.] Dow Chem Co USA, Theoret Separat Sci Lab, Spring House, PA 19477 USA. RP Lenhoff, AM (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. EM lenhoff@udel.edu OI Lenhoff, Abraham/0000-0002-7831-219X FU National Institutes of Health (NIH) [R01 GM75047] FX We thank Paul Miller and Christel Genoud of Gatan Inc. for the serial-sectioning and imaging of our sample with the 3-View system, and Dr. Ulrich Tallarek for providing detailed results of simulations on silica monoliths. Financial support for this work was provided by the National Institutes of Health (NIH) under grant R01 GM75047. NR 94 TC 44 Z9 44 U1 0 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 EI 1873-3778 J9 J CHROMATOGR A JI J. Chromatogr. A PD JUN 3 PY 2011 VL 1218 IS 22 BP 3466 EP 3475 DI 10.1016/j.chroma.2011.03.064 PG 10 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 771BQ UT WOS:000291132600009 PM 21529814 ER PT J AU Kiang, JG Agravante, NG Smith, JT Bowman, PD AF Kiang, Juliann G. Agravante, Neil G. Smith, Joan T. Bowman, Phillip D. TI 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation SO CELL AND BIOSCIENCE LA English DT Article ID NITRIC-OXIDE SYNTHASE; INFLAMMATORY RESPONSE; INDUCIBLE HSP70; LUNG INJURY; APOPTOSIS; EXPRESSION; RATS; IRRADIATION; RADIATION; HYPOXIA AB Background: Hemorrhage increases inducible nitric oxide synthase (iNOS) and depletes ATP levels in various tissues. Previous studies have shown that geldanamycin, an inducer of heat shock protein 70kDa (HSP-70) and inhibitor of iNOS, limits both processes. Reduction in NO production limits lipid peroxidation, apoptosome formation, and caspase-3 activation, thereby increasing cellular survival and reducing the sequelae of hemorrhage. The poor solubility of geldanamycin in aqueous solutions, however, limits its effectiveness as a drug. 17-DMAG is a water-soluble analog of geldanamycin that might have greater therapeutic utility. This study investigated the effectiveness of 17-DMAG at reducing hemorrhagic injury in mouse small intestine. Results: In mice, the hemorrhage-induced iNOS increase correlated with increases in Kruppel-like factor 6 (KLF6) and NF-kB and a decrease in KLF4. As a result, increases in NO production and lipid peroxidation occurred. Moreover, hemorrhage also resulted in decreased Bcl-2 and increased TNF-alpha, IL-6, and IL-10 concentrations, p53 protein, caspase-3 activation, and cellular ATP depletion. A shortening and widening of villi in the small intestine was also observed. Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and TNF-alpha and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration. 17-DMAG treatment by itself upregulated HSP-70, Bcl-2, and p53. Conclusion: Since 17-DMAG is water soluble, bioactive, and not toxic, 17-DMAG may prove useful as a prophylactic drug for hemorrhage. C1 [Kiang, Juliann G.; Agravante, Neil G.; Smith, Joan T.] Uniformed Serv Univ Hlth Sci, Radiat Combined Injury Program, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. [Kiang, Juliann G.] Uniformed Serv Univ Hlth Sci, Dept Radiat Biol, Bethesda, MD 20814 USA. [Kiang, Juliann G.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Bowman, Phillip D.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kiang, JG (reprint author), Uniformed Serv Univ Hlth Sci, Radiat Combined Injury Program, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. EM kiang@afrri.usuhs.mil NR 33 TC 8 Z9 9 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 2045-3701 J9 CELL BIOSCI JI Cell Biosci. PD JUN 3 PY 2011 VL 1 AR 21 DI 10.1186/2045-3701-1-21 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 982OU UT WOS:000307056100001 PM 21711488 ER PT J AU Mac Donald, CL Johnson, AM Cooper, D Nelson, EC Werner, NJ Shimony, JS Snyder, AZ Raichle, ME Witherow, JR Fang, R Flaherty, SF Brody, DL AF Mac Donald, Christine L. Johnson, Ann M. Cooper, Dana Nelson, Elliot C. Werner, Nicole J. Shimony, Joshua S. Snyder, Abraham Z. Raichle, Marcus E. Witherow, John R. Fang, Raymond Flaherty, Stephen F. Brody, David L. TI Detection of Blast-Related Traumatic Brain Injury in U.S. Military Personnel SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID DIFFUSE AXONAL INJURY; AMYLOID PRECURSOR PROTEIN; WHITE-MATTER INJURY; CLOSED-HEAD INJURY; MILD; VETERANS; MEMORY; MODEL; TIME; IRAQ AB Background Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered. Methods We tested the hypothesis that blast-related traumatic brain injury causes traumatic axonal injury, using diffusion tensor imaging (DTI), an advanced form of magnetic resonance imaging that is sensitive to axonal injury. The subjects were 63 U. S. military personnel who had a clinical diagnosis of mild, uncomplicated traumatic brain injury. They were evacuated from the field to the Landstuhl Regional Medical Center in Landstuhl, Germany, where they underwent DTI scanning within 90 days after the injury. All the subjects had primary blast exposure plus another, blast-related mechanism of injury (e. g., being struck by a blunt object or injured in a fall or motor vehicle crash). Controls consisted of 21 military personnel who had blast exposure and other injuries but no clinical diagnosis of traumatic brain injury. Results Abnormalities revealed on DTI were consistent with traumatic axonal injury in many of the subjects with traumatic brain injury. None had detectible intracranial injury on computed tomography. As compared with DTI scans in controls, the scans in the subjects with traumatic brain injury showed marked abnormalities in the middle cerebellar peduncles (P<0.001), in cingulum bundles (P=0.002), and in the right orbitofrontal white matter (P=0.007). In 18 of the 63 subjects with traumatic brain injury, a significantly greater number of abnormalities were found on DTI than would be expected by chance (P<0.001). Follow-up DTI scans in 47 subjects with traumatic brain injury 6 to 12 months after enrollment showed persistent abnormalities that were consistent with evolving injuries. Conclusions DTI findings in U. S. military personnel support the hypothesis that blast-related mild traumatic brain injury can involve axonal injury. However, the contribution of primary blast exposure as compared with that of other types of injury could not be determined directly, since none of the subjects with traumatic brain injury had isolated primary blast injury. Furthermore, many of these subjects did not have abnormalities on DTI. Thus, traumatic brain injury remains a clinical diagnosis. (Funded by the Congressionally Directed Medical Research Program and the National Institutes of Health; ClinicalTrials.gov number, NCT00785304.) C1 [Brody, David L.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA. [Witherow, John R.; Fang, Raymond; Flaherty, Stephen F.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Flaherty, Stephen F.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Brody, DL (reprint author), Washington Univ, Sch Med, Dept Neurol, Biotech Bldg,Rm 201,660 S Euclid Ave,Box 8111, St Louis, MO 63110 USA. EM brodyd@neuro.wustl.edu FU Congressionally Directed Medical Research Program [W81XWH-08-2-0061]; National Institutes of Health [F32NS062529, 5K23HD053212, P30NS048056, P50NS06833, 5K08NS49237] FX Supported by a grant from the Congressionally Directed Medical Research Program (W81XWH-08-2-0061, to Dr. Brody) and the National Institutes of Health (F32NS062529, to Dr. Mac Donald; 5K23HD053212, to Dr. Shimony; P30NS048056, to Dr. Snyder; P50NS06833, to Drs. Raichle and Snyder; and 5K08NS49237, to Dr. Brody.) NR 43 TC 244 Z9 245 U1 5 U2 44 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 2 PY 2011 VL 364 IS 22 BP 2091 EP 2100 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 772AB UT WOS:000291200700007 PM 21631321 ER PT J AU Shewale, V Joshi, P Mukhopadhyay, S Deshpande, M Pandey, R Hussain, S Karna, SP AF Shewale, Vasundhara Joshi, Prachi Mukhopadhyay, Saikat Deshpande, Mrinalini Pandey, Ravindra Hussain, Saber Karna, Shashi P. TI First-Principles Study of Nanoparticle-Biomolecular Interactions: Anchoring of a (ZnO)(12) Cluster on Nucleobases SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID WALLED CARBON NANOTUBES; DNA BASES; ELECTRONIC-PROPERTIES; NANOCOMPONENT ARRAYS; MOLECULAR-DYNAMICS; GOLD CLUSTERS; ZNO CLUSTERS; BINDING; PSEUDOPOTENTIALS; COMPLEXES AB We report the results of theoretical calculations on interaction of the nucleotide bases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) with a (ZnO)(12) duster, carried out within density-functional theory framework. In all cases, (ZnO)(12) prefers to bind with a ring nitrogen atom having a lone electron pair relative to the other possible binding sites of the bases. The degree of hybridization between Zn-d and N-p orbitals determines the relative interaction strength at the N-site of individual nucleobases with (ZnO)(12) in contrast to the cases of interaction of metallic dusters and carbon nanostructures with nucleobases where either electrostatic or van der Waals interactions dominates the bonding characteristics of the conjugate complexes. The predicted site-preference of (ZnO)(12) toward the nucleobases appears to be similar to that of the metal clusters, which indicates that the metal dusters retain their site-preference even in their oxidized state. C1 [Shewale, Vasundhara; Joshi, Prachi; Mukhopadhyay, Saikat; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Shewale, Vasundhara; Deshpande, Mrinalini] HPT Arts & RYK Sci Coll, Dept Phys, Nasik, Maharashtra, India. [Joshi, Prachi] Nat Phys Lab NPL, Delhi, India. [Hussain, Saber] USAF, Res Lab, Dayton, OH 45433 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 20783 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.karna@us.army.mil RI Mukhopadhyay, Saikat/B-4402-2011 FU Department of Science and Technology (DST), Government of India; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. FX We gratefully acknowledge V. Shanker and S. Gowtham for their constructive criticism and fruitful scientific discussions. V.S. and P.J. also acknowledge Michigan Technological University for providing local hospitality. M.D. and V.S. acknowledge the financial assistance from the Department of Science and Technology (DST), Government of India. R.P. acknowledges the financial support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 49 TC 20 Z9 20 U1 1 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUN 2 PY 2011 VL 115 IS 21 BP 10426 EP 10430 DI 10.1021/jp2013545 PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 768EQ UT WOS:000290914700017 ER PT J AU Im, J Singh, J Soares, JW Steeves, DM Whitten, JE AF Im, Jisun Singh, Jagdeep Soares, Jason W. Steeves, Diane M. Whitten, James E. TI Synthesis and Optical Properties of Dithiol-Linked ZnO/Gold Nanoparticle Composites SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID FERMI-LEVEL EQUILIBRATION; SELF-ASSEMBLED MONOLAYERS; ZNO NANOROD ARRAYS; ZINC-OXIDE; METAL NANOPARTICLES; EMISSION; SURFACES; PHOTOLUMINESCENCE; NANOWIRES; GROWTH AB Semiconductor-metal nanocomposites are being pursued for use as a new generation of light emitters and photovoltaic devices. A convenient method for attaching gold nanoparticles (AuNPs) onto zinc oxide nanorods with variable surface densities is described that consists simply of mixing suspensions of monolayer-protected AuNPs and the nanorods in the presence of a dithiol. One end of the dithiol linker bonds to AuNPs via a ligand place-exchange reaction, and the other end attaches to ZnO via Zn-S bonding. The nanocomposites have been characterized by UV-vis absorbance, photoluminescence, and Raman spectroscopies. Attachment of the AuNPs affects the ZnO absorbance and photoluminescence (PL) spectra, resulting in blue shifts of the absorbance and UV excitonic emission peaks. Ultraviolet photoelectron spectroscopy has also been performed on the nanocomposite, zinc oxide nanorod, and gold nanoparticle samples, and an energy level diagram has been constructed. The PL and absorbance shifts are ascribed to the Burstein-Moss effect in which photogenerated electrons accumulate on nearby gold nanoparticles, transfer to the ZnO conduction band, and cause band-gap widening. C1 [Im, Jisun; Singh, Jagdeep; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. [Im, Jisun; Singh, Jagdeep; Whitten, James E.] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Im, Jisun; Singh, Jagdeep; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA. [Soares, Jason W.; Steeves, Diane M.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. EM James_Whitten@uml.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center FX The authors acknowledge the assistance of Dr. Peng Wang at Bruker Optics in obtaining the Raman spectra. This work is supported by U.S. Army Natick Soldier Research, Development, and Engineering Center. NR 51 TC 33 Z9 34 U1 2 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUN 2 PY 2011 VL 115 IS 21 BP 10518 EP 10523 DI 10.1021/jp2024611f PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 768EQ UT WOS:000290914700028 ER PT J AU Dawood, FS Ambrose, JF Russell, BP Hawksworth, AW Winchell, JM Glass, N Thurman, K Soltis, MA McDonough, E Warner, AK Weston, E Clemmons, NS Rosen, J Mitchell, SL Faix, DJ Blair, PJ Moore, MR Lowery, J AF Dawood, Fatimah S. Ambrose, John F. Russell, Bruce P. Hawksworth, Anthony W. Winchell, Jonas M. Glass, Nina Thurman, Kathleen Soltis, Michele A. McDonough, Erin Warner, Agnes K. Weston, Emily Clemmons, Nakia S. Rosen, Jennifer Mitchell, Stephanie L. Faix, Dennis J. Blair, Patrick J. Moore, Matthew R. Lowery, John TI Outbreak of Pneumonia in the Setting of Fatal Pneumococcal Meningitis among US Army Trainees: Potential Role of Chlamydia pneumoniae Infection SO BMC INFECTIOUS DISEASES LA English DT Article DE Pneumonia; pneumococcal; Chlamydophila; pneumoniae; Military Personnel ID REAL-TIME PCR; STREPTOCOCCUS-PNEUMONIAE; MYCOPLASMA-PNEUMONIAE; MILITARY PERSONNEL; EPIDEMIC; FINLAND; COMMUNITY AB Background: Compared to the civilian population, military trainees are often at increased risk for respiratory infections. We investigated an outbreak of radiologically-confirmed pneumonia that was recognized after 2 fatal cases of serotype 7F pneumococcal meningitis were reported in a 303-person military trainee company (Alpha Company). Methods: We reviewed surveillance data on pneumonia and febrile respiratory illness at the training facility; conducted chart reviews for cases of radiologically-confirmed pneumonia; and administered surveys and collected nasopharyngeal swabs from trainees in the outbreak battalion (Alpha and Hotel Companies), associated training staff, and trainees newly joining the battalion. Results: Among Alpha and Hotel Company trainees, the average weekly attack rates of radiologically-confirmed pneumonia were 1.4% and 1.2% (most other companies at FLW: 0-0.4%). The pneumococcal carriage rate among all Alpha Company trainees was 15% with a predominance of serotypes 7F and 3. Chlamydia pneumoniae was identified from 31% of specimens collected from Alpha Company trainees with respiratory symptoms. Conclusion: Although the etiology of the outbreak remains unclear, the identification of both S. pneumoniae and C. pneumoniae among trainees suggests that both pathogens may have contributed either independently or as cofactors to the observed increased incidence of pneumonia in the outbreak battalion and should be considered as possible etiologies in outbreaks of pneumonia in the military population. C1 [Dawood, Fatimah S.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, Atlanta, GA 30333 USA. [Winchell, Jonas M.; Glass, Nina; Thurman, Kathleen; Warner, Agnes K.; Weston, Emily; Rosen, Jennifer; Mitchell, Stephanie L.; Moore, Matthew R.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Ambrose, John F.; Soltis, Michele A.; Clemmons, Nakia S.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Russell, Bruce P.] Gen Leonard Wood Army Community Hosp, Div Prevent Med, Ft Leonard Wood, MO 65473 USA. [Hawksworth, Anthony W.; McDonough, Erin; Faix, Dennis J.; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM fdawood@cdc.gov; zdn4@cdc.gov RI Valle, Ruben/A-7512-2013; OI Glass, Nina/0000-0002-6821-4289 NR 19 TC 11 Z9 11 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUN 2 PY 2011 VL 11 AR 157 DI 10.1186/1471-2334-11-157 PG 9 WC Infectious Diseases SC Infectious Diseases GA 783KN UT WOS:000292081300001 PM 21635754 ER PT J AU Tabiryan, NV Nersisyan, SR White, TJ Bunning, TJ Steeves, DM Kimball, BR AF Tabiryan, Nelson V. Nersisyan, Sarik R. White, Timothy J. Bunning, Timothy J. Steeves, Diane M. Kimball, Brian R. TI Transparent thin film polarizing and optical control systems SO AIP ADVANCES LA English DT Article ID LIQUID-CRYSTALS; POLARIZATION GRATINGS; HIGH-EFFICIENCY; DIFFRACTION AB We show that a diffractive waveplate can be combined with a phase retardation film for fully converting light of arbitrary polarization state into a polarized light. Incorporating a photonic bandgap layer into a system of such polarizers that unify different polarization states in the input light into a single polarization state at its output, rather than absorbing or reflecting half of it, we developed and demonstrated a polarization-independent optical controller capable of switching between transmittive and reflective states. The transition between those states is smoothly controlled with low-voltage and low-power sources. Using versatile fabrication methods, this "universally polarizing optical controller" can be integrated into a thin package compatible with a variety of display, spatial light modulation, optical communication, imaging and other photonics systems. Copyright 2011 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. [doi:10.1063/1.3609965] C1 [Tabiryan, Nelson V.; Nersisyan, Sarik R.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [White, Timothy J.; Bunning, Timothy J.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Tabiryan, NV (reprint author), Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. EM nelson@beamco.org RI White, Timothy/D-4392-2012 FU AFRL HMRSS [FA8650-09-D-5434, 009]; U.S. Army Natick Soldier Research, Development & Engineering Center [W911QY-10-C-0089] FX This work was performed with the support of the AFRL HMRSS Program (Prime contract FA8650-09-D-5434, Task Order 009), and the U.S. Army Natick Soldier Research, Development & Engineering Center (Contract W911QY-10-C-0089). Approved for public release (OPSEC # U11-152). NR 14 TC 13 Z9 13 U1 1 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 2158-3226 J9 AIP ADV JI AIP Adv. PD JUN PY 2011 VL 1 IS 2 AR 022153 DI 10.1063/1.3609965 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 916XR UT WOS:000302137000051 ER PT J AU Wilder-Kofie, TD Luquez, C Adler, M Dykes, JK Coleman, JD Maslanka, SE AF Wilder-Kofie, Temeri D. Luquez, Carolina Adler, Michael Dykes, Janet K. Coleman, JoAnn D. Maslanka, Susan E. TI An Alternative In Vivo Method to Refine the Mouse Bioassay for Botulinum Toxin Detection SO COMPARATIVE MEDICINE LA English DT Article ID NEUROTOXIN; MUSCLE AB Botulism is a rare, life-threatening paralytic disease of both humans and animals that is caused by botulinum neurotoxins (BoNT). Botulism is confirmed in the laboratory by the detection of BoNT in clinical specimens, contaminated foods, and cultures. Despite efforts to develop an in vitro method for botulinum toxin detection, the mouse bioassay remains the standard test for laboratory confirmation of this disease. In this study, we evaluated the use of a nonlethal mouse toe-spread reflex model to detect BoNT spiked into buffer, serum, and milk samples. Samples spiked with toxin serotype A and nontoxin control samples were injected into the left and right extensor digitorum longus muscles, respectively. Digital photographs at 0, 8, and 24 h were used to obtain objective measurements through effective paralysis scores, which were determined by comparing the width-to-length ratio between right and left feet. Both objective measurements and clinical observation could accurately identify over 80% of animals injected with 1 LD50 (4.3 pg) BoNT type A within 24 h. Half of animals injected with 0.5 LD50 BoNT type A and none injected with 0.25 LD50 demonstrated localized paralysis. Preincubating the toxin with antitoxin prevented the development of positive effective paralysis scores, demonstrating that (1) the effect was specific for BoNT and (2) identification of toxin serotype could be achieved by using this method. These results suggest that the mouse toe-spread reflex model may be a more humane alternative to the current mouse bioassay for laboratory investigations of botulism. C1 [Luquez, Carolina; Dykes, Janet K.; Maslanka, Susan E.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Wilder-Kofie, Temeri D.; Coleman, JoAnn D.] Ctr Dis Control & Prevent, Div Sci Resources, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Adler, Michael] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Maslanka, SE (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. EM SMaslanka@cdc.gov FU Office for Public Health (Centers for Disease Control and Prevention, Atlanta, GA); CDC Laboratory Animal Medicine Residency, Division of Scientific Resources, National Center for Emerging Zoonotic and Infectious Disease FX This publication was supported by funds made available from the Office for Public Health Preparedness and Response (Centers for Disease Control and Prevention, Atlanta, GA). Additional funds were made available from the CDC Laboratory Animal Medicine Residency Program, Division of Scientific Resources, National Center for Emerging Zoonotic and Infectious Disease. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 18 TC 13 Z9 13 U1 1 U2 12 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD JUN PY 2011 VL 61 IS 3 BP 235 EP 242 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 915QQ UT WOS:000302042900007 PM 21819693 ER PT J AU Smawley, GR AF Smawley, George R. TI IN PURSUIT OF JUSTICE, A LIFE OF LAW AND PUBLIC SERVICE: UNITED STATES DISTRICT COURT JUDGE AND BRIGADIER GENERAL (RETIRED) WAYNE E. ALLEY (US ARMY, 1952-1954, 1959-1981) SO MILITARY LAW REVIEW LA English DT Article ID JR. C1 [Smawley, George R.] 10th Mt Div Light Infantry, Ft Drum, NY USA. [Smawley, George R.] Ft Drum, Ft Drum, NY USA. [Smawley, George R.] OTJAG, Personnel Plans & Training Off, Washington, DC USA. [Smawley, George R.] USA, Special Operat Command, Ft Bragg, NC USA. [Smawley, George R.] Claims Div, Ft Benning, GA USA. [Smawley, George R.] 6th Infantry Div Light, Claims Branch, Ft Wainwright, AK USA. RP Smawley, GR (reprint author), 25th Infantry Div, Camp Liberty, Iraq. NR 41 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2011 VL 208 BP 213 EP 306 PG 94 WC Law SC Government & Law GA 895DO UT WOS:000300476600002 ER PT J AU Borch, FL AF Borch, Fred L., III TI FRAGGING: WHY U.S. SOLDIERS ASSAULTED THEIR OFFICERS IN VIETNAM SO MILITARY LAW REVIEW LA English DT Book Review C1 [Borch, Fred L., III] USA, Judge Advocate Gen Corps, Washington, DC 20301 USA. RP Borch, FL (reprint author), USA, Judge Advocate Gen Corps, Washington, DC 20301 USA. NR 6 TC 0 Z9 0 U1 0 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2011 VL 208 BP 307 EP 312 PG 6 WC Law SC Government & Law GA 895DO UT WOS:000300476600003 ER PT J AU McLeod, CC AF McLeod, Charles C., Jr. TI KING'S COUNSEL: A MEMOIR OF WAR, ESPIONAGE, AND DIPLOMACY IN THE MIDDLE EAST SO MILITARY LAW REVIEW LA English DT Book Review C1 [McLeod, Charles C., Jr.] US Marine Corps, Kansas City, MO 64147 USA. [McLeod, Charles C., Jr.] USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 60, Charlottesville, VA USA. RP McLeod, CC (reprint author), US Marine Corps, Kansas City, MO 64147 USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2011 VL 208 BP 313 EP 324 PG 12 WC Law SC Government & Law GA 895DO UT WOS:000300476600004 ER PT J AU Hammond, RT Pilling, T AF Hammond, Richard T. Pilling, Terry TI Dark entropy SO PHYSICS ESSAYS LA English DT Article DE Thermodynamics; Cosmology ID HUBBLE-SPACE-TELESCOPE; COSMOLOGICAL TERM; BLACK-HOLES; CONSTRAINTS; MODELS AB We examine the consequences of a universe with a nonconstant cosmological term in Einstein's equations and find that the Bianchi identities reduce to the something analogous first law of thermodynamics when cosmological term is identified as being proportional to the entropy density of the universe. This means that gravitating dark energy can be viewed as entropy, but more, the holographic principle along with the known expansion of the universe indicates that the entropy of the universe is growing with time and this leads to a cosmic repulsion that also grows with time. Direct implications of this result are calculated and shown to be in good accord with recent observational data. (C) 2011 Physics Essays Publication. [DOI: 10.4006/1.3565950] C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Res Triangle Pk, NC 27703 USA. [Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27703 USA. [Pilling, Terry] N Dakota State Univ, Dept Phys, Fargo, ND 58105 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Res Triangle Pk, NC 27703 USA. EM rhammond@email.unc.edu; terry.pilling@ndsu.edu NR 16 TC 1 Z9 1 U1 0 U2 1 PU PHYSICS ESSAYS PUBLICATION PI OTTAWA PA PO BOX 8141 STATION T, OTTAWA, ONTARIO K1G 3H6, CANADA SN 0836-1398 J9 PHYS ESSAYS JI Phys. Essays PD JUN PY 2011 VL 24 IS 2 BP 196 EP 199 DI 10.4006/1.3565950 PG 4 WC Physics, Multidisciplinary SC Physics GA 879YT UT WOS:000299371400009 ER PT J AU Ter-Gabrielyan, N Fromzel, V Merkle, LD Dubinskii, M AF Ter-Gabrielyan, Nikolay Fromzel, Viktor Merkle, Larry D. Dubinskii, Mark TI Resonant in-band pumping of cryo-cooled Er3+:YAG laser at 1532, 1534 and 1546 nm: a comparative study SO OPTICAL MATERIALS EXPRESS LA English DT Article ID SOLID-STATE LASERS; UP-CONVERSION; TEMPERATURE AB Spectroscopic features of Er:YAG at cryogenic temperatures are studied in detail. We report that the major absorption line at similar to 1532.3 nm is much narrower and much stronger than previously measured. Spectroscopic analysis suggests that its impact on the laser performance is limited because of the strong pump saturation effect. It is shown that the high efficiency of the laser is, in fact, achieved due to absorption in the wing of this line, which is comprised of a few other transitions. It is also shown that pumping into the relatively weak 1534 nm absorption line provides practically the same laser efficiency (similar to 75%) as pumping into the major 1532 nm absorption line. This is explained by a numerical laser model which takes into account saturation effects of pump and laser intensities. The model is validated by experimental data. (C)2011 Optical Society of America C1 [Ter-Gabrielyan, Nikolay; Fromzel, Viktor; Merkle, Larry D.; Dubinskii, Mark] USA, Res Lab, Attn RDRL SEE M, Adelphi, MD 20783 USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, Attn RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nick.tergabrielyan@arl.army.mil NR 12 TC 10 Z9 10 U1 0 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD JUN 1 PY 2011 VL 1 IS 2 BP 223 EP 233 PG 11 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 875QB UT WOS:000299046900012 ER PT J AU Chappell, MA Price, CL Miller, LF AF Chappell, Mark A. Price, Cynthia L. Miller, Lesley F. TI Solid-phase considerations for the environmental fate of nitrobenzene and triazine munition constituents in soil SO APPLIED GEOCHEMISTRY LA English DT Article ID WATER SLURRIES; TNT; ATRAZINE; RDX; TRANSFORMATION; REDUCTION; SMECTITE; PH AB This paper focuses on the chemistry of DoD-relevant organic contaminants in soil. Most of the work presented here is based on the author's experience with the environmental fate of the munition constituents, TNT and RDX, for DoD related issues. The principles and challenges of understanding the transport of nitrobenzene and triazine compounds in the environment are captured. In this work, disparities in the current scientific literature with respect to the construction of sorption experiments are discussed, in terms of soil sample handling, dispersion state of the soil, and sorption hysteresis/equilibrium. Here is discussed the concept of environmentally formulated compounds and its implications toward reduced accuracy of predicting the environmental fate of munition constituents. Also, further research linking simple but oft-forgotten basic concepts of soil fertility to the transport and environmental fate of munition constituents are discussed. Published by Elsevier Ltd. C1 [Chappell, Mark A.; Price, Cynthia L.; Miller, Lesley F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Chappell, MA (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM Mark.A.Chappell@usace.army.mil NR 19 TC 3 Z9 3 U1 0 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0883-2927 J9 APPL GEOCHEM JI Appl. Geochem. PD JUN PY 2011 VL 26 SU S BP S330 EP S333 DI 10.1016/j.apgeochem.2011.03.067 PG 4 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 858HZ UT WOS:000297788100096 ER PT J AU Onlamoon, N Tabprasit, S Sukapirom, K Polsira, K Ammaranond, P Loharungsikul, S Pattanapanyasat, K AF Onlamoon, Nattawat Tabprasit, Sutchana Sukapirom, Kasama Polsira, Korakot Ammaranond, Palanee Loharungsikul, Somying Pattanapanyasat, Kovit TI Discordant CD38 measurement of CD8+T lymphocytes using fluorescein conjugates in comparison with phycoerythrin conjugates SO ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY LA English DT Article DE CD38; fluorescein; HIV; monoclonal antibody; phycoetythrin ID T-CELL-ACTIVATION; ACTIVE ANTIRETROVIRAL THERAPY; MULTICENTER AIDS COHORT; VIRUS-INFECTED PATIENTS; HIV-1 INFECTION; HIV-1-INFECTED PATIENTS; ANTIGEN-EXPRESSION; FOLLOW-UP; CD4(+); IMMUNODEFICIENCY AB Background: We have previously shown that monitoring of CD38 expression can be used as a marker for antiretroviral drug efficacy in HIV infected patients. However, the detection of CD38 expression may be affected by the sensitivity of the fluorochrome conjugated reagent. Objective: In this study, we determined the level of CD38 expression using PE and FITC conjugated anti-CD38 monoclonal antibodies in different groups of HIV infected patients. Methods: The frequency and mean fluorescence intensity of CD38 expression using PE and FITC conjugated anti-CD38 monoclonal antibodies were detected by flow cytometry either alone or in combination with HLA-DR. A correlation between CD38 expression and CD4 count, the percentage of CD4 or viral load in antiretroviral drug naive HIV infected patients was performed. The results were compared with those for antiretroviral treated HIV infected patients who responsed to therapy and patients with virological failure. Results: We found that while both reagents had the ability to detect a high frequency of CD38 expressing cells in untreated patients, only PE conjugated reagent provided correlation with markers for disease progression. More importantly, FITC conjugated reagent cannot monitor the increase in CD38 expression in patients who showed virological failure. Conclusions: The results from this study suggest that a cautious selection of fluorochrome conjugated reagents and a method for utilizing the data are extremely critical in the use of CD38 expression as a monitoring tool for ART efficacy. (Asian Pac J Allergy Immunol 2011;29:181-9) C1 [Onlamoon, Nattawat; Sukapirom, Kasama; Polsira, Korakot; Pattanapanyasat, Kovit] Mahidol Univ, Ctr Excellence Flow Cytometry, Off Res & Dev, Fac Med,Siriraj Hosp, Bangkok 10700, Thailand. [Tabprasit, Sutchana] Armed Forces Res Inst Med Sci, Royal Thai Army Med Dept, Bangkok 10400, Thailand. [Ammaranond, Palanee] Chulalongkorn Univ, Innovat Ctr Res & Dev Med Diagnost Technol Projec, Dept Transfus Med, Fac Allied Hlth Sci, Bangkok, Thailand. [Loharungsikul, Somying] Mahidol Univ, Dept Clin Microbiol & Appl Technol, Fac Med Technol, Bangkok 10700, Thailand. RP Onlamoon, N (reprint author), Mahidol Univ, Ctr Excellence Flow Cytometry, Off Res & Dev, Fac Med,Siriraj Hosp, Bangkok 10700, Thailand. EM sinol@mahidol.ac.th OI Onlamoon, Nattawat/0000-0002-8784-3005 FU Office of the Higher Education Commission; Mahidol University under National Research Universities Initiative; Thailand Research Fund; Faculty of Medicine Siriaj Hospital; Chulalongkorn University FX This project is supported by the Office of the Higher Education Commission and Mahidol University under the National Research Universities Initiative as well as the Senior Research Scholar grant from the Thailand Research Fund (to KP). KP and NO are supported by a Chalermphrakiat Grant from Faculty of Medicine Siriaj Hospital. PA is supported by Chulalongkorn University Centenary Academic Development Project. NR 22 TC 0 Z9 0 U1 0 U2 1 PU ALLERGY IMMUNOL SOC THAILAND, PI BANGKOK PA MAHIDOL UNIV, DEPT MICROBIOL IMMUNOL, FACULTY TROPICAL MED, BANGKOK 10400, THAILAND SN 0125-877X J9 ASIAN PAC J ALLERGY JI Asian Pac. J. Allergy Immunol. PD JUN PY 2011 VL 29 IS 2 BP 181 EP 189 PG 9 WC Allergy; Immunology SC Allergy; Immunology GA 852WW UT WOS:000297389200010 PM 21980834 ER PT J AU Batchinsky, AI Jordan, BS Regn, D Necsoiu, C Federspiel, WJ Morris, MJ Cancio, LC AF Batchinsky, Andriy I. Jordan, Bryan S. Regn, Dara Necsoiu, Corina Federspiel, William J. Morris, Michael J. Cancio, Leopoldo C. TI Respiratory dialysis: Reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal SO CRITICAL CARE MEDICINE LA English DT Article DE lung-protective ventilation; mechanical ventilation; extracorporeal circulation; CO2 removal; respiratory dialysis; swine ID CARBON-DIOXIDE REMOVAL; ACUTE LUNG INJURY; DISTRESS-SYNDROME SECONDARY; IMPROVES 5-DAY OUTCOMES; ARTIFICIAL LUNG; MEMBRANE-OXYGENATION; BATTLE CASUALTIES; CHLORINE GAS; SHEEP; FAILURE AB Objectives: Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better lung-replacement approaches. We investigated the ability of a novel extracorporeal venovenous CO2 removal device to reduce minute ventilation while maintaining normocarbia. Design: Prospective animal study. Setting: Government laboratory animal intensive care unit. Subjects: Seven sedated swine. Interventions: Tracheostomy, volume-controlled mechanical ventilation, and 72 hrs of round-the-clock intensive care unit care. A 15-F dual-lumen catheter was inserted in the external jugular vein and connected to the Hemolung, an extracorporeal pump-driven venovenous CO2 removal device. Minute ventilation was reduced, and normocarbia (Paco(2) 35-45 mm Hg) maintained. Heparinization was maintained at an activated clotting time of 150-180 secs. Measurements and Main Results: Minute ventilation (L/min), CO2 removal by Hemolung (mL/min), Hemolung blood flow, O-2 consumption (mL/min), CO2 production by the lung (mL/min), Paco(2), and plasma-free hemoglobin (g/dL) were measured at baseline (where applicable), 2 hrs after device insertion, and every 6 hrs thereafter. Minute ventilation was reduced from 5.6 L/min at baseline to 2.6 L/min 2 hrs after device insertion and was maintained at 3 L/min until the end of the study. CO2 removal by Hemolung remained steady over 72 hrs, averaging 72 +/- 1.2 mL/min at blood flows of 447 +/- 5 mL/min. After insertion, O-2 consumption did not change; CO2 production by the lung decreased by 50% and stayed at that level (p < .001). As the arterial PCO2 rose or fell, so did CO2 removal by Hemolung. Plasma-free hemoglobin did not change. Conclusions: Venovenous CO2 removal enabled a 50% reduction in minute ventilation while maintaining normocarbia and may be an effective lung-protective adjunct to mechanical ventilation. (Crit Care Med 2011; 39:1382-1387) C1 [Batchinsky, Andriy I.; Jordan, Bryan S.; Necsoiu, Corina; Cancio, Leopoldo C.] USA, Inst Surg Res, San Antonio, TX USA. [Regn, Dara; Morris, Michael J.] Brooke Army Med Ctr, Pulm & Crit Care Serv, San Antonio, TX USA. [Federspiel, William J.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, San Antonio, TX USA. EM andriy.batchinsky@amedd.army.mil NR 50 TC 56 Z9 57 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2011 VL 39 IS 6 BP 1382 EP 1387 DI 10.1097/CCM.0b013e31820eda45 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 765NM UT WOS:000290715000022 PM 21317644 ER PT J AU Kotzer, AM Zacharakis, SK Raynolds, M Buenning, F AF Kotzer, Anne Marie Zacharakis, Susan Koch Raynolds, Mary Buenning, Fred TI Evaluation of the Built Environment: Staff and Family Satisfaction Pre- and Post-Occupancy of The Children's Hospital SO HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL LA English DT Article DE Evidence-based design; healthcare design; hospital design; satisfaction surveys; family satisfaction; staff satisfaction; built environment; research design and methodology ID INTENSIVE-CARE-UNIT; QUALITY-OF-LIFE; PRETERM INFANTS; LIGHT EXPOSURE; HEALTH; NOISE; SUNLIGHT; DESIGN; CAREGIVERS; FACILITIES AB Objective: To evaluate and compare the impact of an existing and newly built hospital environment on family and staff satisfaction related to light, noise, temperature, aesthetics, and amenities, as well as safety, security, and privacy. Background: The United States is engaged in an unprecedented healthcare building boom driven by the need to replace aging facilities, understand the impact of the built environment on quality and safety, incorporate rapidly emerging technologies, and enhance patient- and family-centered care. More importantly, there is heightened attention to creating optimal physical environments to achieve the best possible outcomes for patients, families, and staff. Methods: Using a pre-post descriptive survey design, all nursing, social work, therapy staff, and families on selected inpatient units were invited to participate. A demographic form and Family and Staff Satisfaction Surveys were developed and administered pre- and post-occupancy of the new facility. Results: Pre/post mean scores for staff satisfaction improved on all survey subscales with statistically significant improvement (p < .05) in most areas. The most improvement was seen with layout of the patient room, natural light, storage and writing surfaces, and comfort and appeal. Family satisfaction demonstrated statistically significant improvement on all subscales (p <= .01), especially for natural light, quiet space, parking, and the child's room as a healing environment. Conclusions: Families and staff reported greater satisfaction with the newly built hospital environment compared to the old facility. Study results will help guide future architectural design decisions, attract and retain staff at a world-class facility, and create the most effective healing environments. C1 [Kotzer, Anne Marie] Childrens Hosp Colorado, Aurora, CO USA. [Zacharakis, Susan Koch] USA, Med Command, Ft Riley, KS USA. [Raynolds, Mary; Buenning, Fred] H L Architecture, Denver, CO USA. RP Kotzer, AM (reprint author), Childrens Hosp, 13123 E 16th Ave,B725, Aurora, CO 80045 USA. EM kotzer.annemarie@tchden.org RI Davis, Mark/J-5101-2015 NR 52 TC 12 Z9 12 U1 4 U2 35 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 1937-5867 J9 HERD-HEALTH ENV RES JI Herd-Health Env. Res. Des. J. PD SUM PY 2011 VL 4 IS 4 BP 60 EP 78 PG 19 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 827JM UT WOS:000295424800005 PM 21960192 ER PT J AU Busby, R Stromberger, M Denight, M Gebhart, D Rodriguez, G Paschke, M AF Busby, R. Stromberger, M. Denight, M. Gebhart, D. Rodriguez, G. Paschke, M. TI Arbuscular mycorrhizal fungi diversity associated with coexisting cheatgrass and big sagebrush communities SO PHYTOPATHOLOGY LA English DT Meeting Abstract C1 [Busby, R.; Denight, M.; Gebhart, D.; Rodriguez, G.] USA, Engn Res & Dev Ctr, Champaign, IL USA. [Stromberger, M.] Colorado State Univ, Dept Soil & Crop Sci, Ft Collins, CO 80523 USA. [Paschke, M.] Colorado State Univ, Dept Forest Rangeland Watershed Stewardship, Ft Collins, CO 80523 USA. NR 0 TC 1 Z9 1 U1 1 U2 13 PU AMER PHYTOPATHOLOGICAL SOC PI ST PAUL PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA SN 0031-949X J9 PHYTOPATHOLOGY JI Phytopathology PD JUN PY 2011 VL 101 IS 6 SU S BP S23 EP S23 PG 1 WC Plant Sciences SC Plant Sciences GA 822KR UT WOS:000295045400133 ER PT J AU Mathioni, S Caplan, J Patel, N Czymmek, KJ Sullivan, RF Kobayashi, DY Donofrio, NM AF Mathioni, S. Caplan, J. Patel, N. Czymmek, K. J. Sullivan, R. F. Kobayashi, D. Y. Donofrio, N. M. TI Understanding cellular and molecular interactions between the rice blast fungus and a putative biocontrol bacterium SO PHYTOPATHOLOGY LA English DT Meeting Abstract C1 [Mathioni, S.; Czymmek, K. J.; Donofrio, N. M.] Univ Delaware, Newark, DE USA. [Caplan, J.] Delaware Biotechnol Inst, Newark, DE USA. [Patel, N.; Kobayashi, D. Y.] Rutgers State Univ, New Brunswick, NJ 08903 USA. [Sullivan, R. F.] USA, Aberdeen Proving Ground, Aberdeen, MD USA. RI Rechsteiner, Cindy/I-4137-2013 NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER PHYTOPATHOLOGICAL SOC PI ST PAUL PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA SN 0031-949X J9 PHYTOPATHOLOGY JI Phytopathology PD JUN PY 2011 VL 101 IS 6 SU S BP S116 EP S116 PG 1 WC Plant Sciences SC Plant Sciences GA 822KR UT WOS:000295045401092 ER PT J AU Osborn, RL Forys, KL Psota, TL Sbrocco, T AF Osborn, Robyn L. Forys, Kelly L. Psota, Tricia L. Sbrocco, Tracy TI YO-YO DIETING IN AFRICAN AMERICAN WOMEN: WEIGHT CYCLING AND HEALTH SO ETHNICITY & DISEASE LA English DT Article DE Weight Loss; African American Women; Blood Pressure; Weight Cycling ID BODY DISSATISFACTION; OBESE WOMEN; PSYCHOLOGICAL HEALTH; LIFETIME WEIGHT; BLOOD-PRESSURE; SELF-ESTEEM; VALIDATION; HYPERTENSION; INVENTORY; DIETERS AB Objective: Research on the effects of weight cycling on health is mixed, strife with inconsistent definitions and the exclusion of African Americans. This study examined weight cycling prevalence among African American women prior to enrolling in a weight management program. Associations of weight cycling with physical and psychological health were conducted. Design: Cross-sectional analysis. Setting: Community-based weight-management program. Participants: 167 overweight or obese treatment-seeking African American women. Main Outcome Measures: Weight cycling was examined in relation to physiological factors, including eating pathology, mood, self esteem, and physical health, specifically current weight, ideal weight, peak weight, and blood pressure. Results: Weight cycling was prevalent (63%). Cyclers had higher current and peak weights (P<.01). Blood pressure did not differ between groups. Cyclers had higher drive for thinness, less body satisfaction, and less self-esteem for appearance (P<.05). Conclusion: African American women are at risk for weight cycling and it may be associated with greater weight and poorer measures of psychological health. (Ethn Dis. 2011;21(3): 274-280) C1 [Osborn, Robyn L.; Psota, Tricia L.; Sbrocco, Tracy] Uniformed Serv Univ Hlth Sci, USU Ctr Hlth Dispar, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Forys, Kelly L.] USA, Publ Hlth Command, Washington, DC USA. RP Osborn, RL (reprint author), Uniformed Serv Univ Hlth Sci, USU Ctr Hlth Dispar, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM rosborn@usuhs.mil FU National Center on Minority Health and Health Disparities [P20MD000505] FX Funding for this project was made possible (in part) by P20MD000505 from the National Center on Minority Health and Health Disparities. The views expressed here do not necessarily reflect the official policies of the Department of Health and Human Services nor does mention by trade names, commercial practices, or organizations imply endorsement by the US Government. NR 46 TC 4 Z9 4 U1 0 U2 7 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X J9 ETHNIC DIS JI Ethn. Dis. PD SUM PY 2011 VL 21 IS 3 BP 274 EP 280 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 820UB UT WOS:000294930500003 PM 21942158 ER PT J AU Enewold, L Zhou, J Devesa, SS Erickson, RL Zhu, K McGlynn, KA AF Enewold, L. Zhou, J. Devesa, S. S. Erickson, R. L. Zhu, K. McGlynn, K. A. TI TRENDS IN TESTICULAR GERM CELL TUMORS AMONG US MILITARY SERVICEMEN, 1990-2003 SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Enewold, L.; Zhou, J.; Devesa, S. S.; Erickson, R. L.; Zhu, K.; McGlynn, K. A.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S163 EP S163 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114600637 ER PT J AU Enewold, L Zhou, J McGlynn, KA Anderson, W Shriver, CD Potter, JF Zahm, SH Zhu, K AF Enewold, L. Zhou, J. McGlynn, K. A. Anderson, W. Shriver, C. D. Potter, J. F. Zahm, S. H. Zhu, K. TI RACIAL VARIATION IN BREAST CANCER TREATMENT AMONG DEPARTMENT OF DEFENSE BENEFICIARIES SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Enewold, L.; Zhou, J.; McGlynn, K. A.; Anderson, W.; Shriver, C. D.; Potter, J. F.; Zahm, S. H.; Zhu, K.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RI Zahm, Shelia/B-5025-2015 NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S5 EP S5 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114600020 ER PT J AU Fisher, JA Weber, NS Cowan, DN Niebuhr, DW AF Fisher, Jared A. Weber, Natalya S. Cowan, David N. Niebuhr, David W. TI INCIDENCE AND RISK FACTORS OF MAJOR DEPRESSIVE DISORDER AMONG US MILITARY PERSONNEL 2000-2009 SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Fisher, Jared A.; Weber, Natalya S.; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S327 EP S327 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114601568 ER PT J AU Gallaway, M Millikan, A Bell, M Perales, R Bibio, D Fink, D Lagana-Riordan, C AF Gallaway, M. Millikan, A. Bell, M. Perales, R. Bibio, D. Fink, D. Lagana-Riordan, C. TI BEHAVIORAL HEALTH FIELD INVESTIGATIONS OF VIOLENT CRIME: METHODOLOGY & RESULTS IN A MILITARY POPULATION SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Gallaway, M.; Millikan, A.; Bell, M.; Perales, R.; Bibio, D.; Fink, D.; Lagana-Riordan, C.] USA, Publ Hlth Command, Gunpowder, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S290 EP S290 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114601420 ER PT J AU Herrell, RK Bliese, PB Hoge, CW AF Herrell, R. K. Bliese, P. B. Hoge, C. W. TI NUMBER OF DEPLOYMENTS AND TOTAL MONTHS OF DEPLOYMENT AS PREDICTORS OF POST-TRAUMATIC STRESS DISORDER IN ACTIVE DUTY SOLDIERS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Herrell, R. K.; Bliese, P. B.; Hoge, C. W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S289 EP S289 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114601419 ER PT J AU Weber, NS Fisher, JA Cowan, DN Postolache, TT Page, WF Niebuhr, DW AF Weber, N. S. Fisher, J. A. Cowan, D. N. Postolache, T. T. Page, W. F. Niebuhr, D. W. TI DESCRIPTIVE EPIDEMIOLOGY AND UNDERLYING PSYCHIATRIC CONDITIONS AMONG SUICIDE ATTEMPTERS IN THE NATIONAL HOSPITAL DISCHARGE SURVEY (NHDS) SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 3rd North American Congress of Epidemiology CY JUN 21-24, 2011 CL Montreal, CANADA C1 [Weber, N. S.; Fisher, J. A.; Cowan, D. N.; Postolache, T. T.; Page, W. F.; Niebuhr, D. W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2011 VL 173 SU 11 BP S289 EP S289 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 810GU UT WOS:000294114601416 ER PT J AU Ryan, DS Coe, CD Howard, RS Edwards, JD Bower, KS AF Ryan, Denise S. Coe, Charles D. Howard, Robin S. Edwards, Jayson D. Bower, Kraig S. TI Corneal Biomechanics Following Epi-LASIK SO JOURNAL OF REFRACTIVE SURGERY LA English DT Article ID IN-SITU KERATOMILEUSIS; OCULAR RESPONSE ANALYZER; GOLDMANN APPLANATION TONOMETRY; INTRAOCULAR-PRESSURE; PHOTOREFRACTIVE KERATECTOMY; DIURNAL-VARIATION; LASER; HYSTERESIS; FLAP AB PURPOSE: To evaluate corneal biomechanical changes following epi-LASIK. METHODS: In this prospective study of 51 patients, corneal hysteresis (CH), corneal resistance factor (CRF), and intraocular pressure (IOP) were assessed using the Ocular Response Analyzer (ORA, Reichert Technologies) preoperatively and at 1, 3, 6, and 12 months after epi-LASIK. Repeated measures analysis of variance (ANOVA) was used to compare changes over time (alpha = .05). Intraocular pressure was also measured by Goldmann applanation tonometry. RESULTS: Corneal hysteresis decreased from 10.22 +/- 1.65 mmHg preoperatively to 8.17 +/- 1.25 mmHg at 1 month, 8.46 +/- 1.44 mmHg at 3 months, 8.63 +/- 1.31 mmHg at 6 months, and 8.53 +/- 1.49 mmHg at 12 months. Corneal resistance factor decreased from 10.01 +/- 1.80 mmHg preoperatively to 7.82 1.68, 8.03 +/- 1.85, 7.77 +/- 1.50, and 7.80 +/- 1.66 mmHg at 1, 3, 6, and 12 months, respectively. Repeated measures ANOVA showed a significant change over time for both CH and CRF (P < .0005). All measures of IOP changed significantly over time (P < .0005). CONCLUSIONS: Epi-LASIK resulted in a significant change in CH and CRF postoperatively. Although some recovery occurred over time, CH, CRF, and IOP did not revert to preoperative levels. [J Refract Surg. 2011;27(6):458-464.] doi:10.3928/1081597X-20110112-01 C1 [Ryan, Denise S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Biostat Serv, Washington, DC 20307 USA. [Edwards, Jayson D.] Univ Florida, Coll Med, Dept Ophthalmol, Jacksonville, FL USA. RP Ryan, DS (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM denise.sediq@amedd.army.mil NR 19 TC 13 Z9 15 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 1081-597X J9 J REFRACT SURG JI J. Refractive Surg. PD JUN PY 2011 VL 27 IS 6 BP 458 EP 464 DI 10.3928/1081597X-20110112-01 PG 7 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 812CW UT WOS:000294266300010 PM 21243973 ER PT J AU Nolan, J Brietzke, SE AF Nolan, Jennifer Brietzke, Scott E. TI Systematic Review of Pediatric Tonsil Size and Polysomnogram-Measured Obstructive Sleep Apnea Severity SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review ID CHILDREN; PREVALENCE; OBESE AB Objective. Systematically review the biomedical literature for data comparing clinical, subjective tonsil size (0-4+ scale) to objectively measured obstructive sleep apnea syndrome (OSAS) using polysomnography (PSG). Data Sources. PubMed database. Review Methods. A comprehensive PubMed MeSH search was conducted to identify articles comparing subjective tonsil size to objectively measured OSAS. Inclusion criteria included pediatric patients only, sample size greater than 5, and sufficient data to extract for analysis. Exclusion criteria included patients with obesity or craniofacial syndromes. Results. Twenty articles were included in the final data set. The mean sample size was 161 (range, 32-700) and grand mean age was 6.7 (range, 2.7-11.7). Case series (evidence based medicine [EBM] level 4) was the predominant study design (16 studies). Eleven of 20 studies concluded there was an association between subjective tonsil size and objective OSAS, whereas 9 did not. Varying statistical techniques were used including simple diagnostic tables (k = 8), linear or logistic regression (k = 19), correlation (k = 5), and analysis of variance (k = 2). A customized quality assessment of each study was performed. Studies showing no association between tonsil size and OSAS had a higher quality score than studies showing an association (3.22 vs 2.36, P = .0317). Conclusion. The association between subjective pediatric tonsil size using 0-41 scale and objective OSAS severity is weak at best. High-quality studies suggest no association. Providers must recognize the limitations of using tonsil size in clinical decision making. C1 [Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Nolan, Jennifer] Natl Naval Med Ctr, Bethesda, MD USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM SEBrietzke@msn.com NR 27 TC 38 Z9 39 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUN PY 2011 VL 144 IS 6 BP 844 EP 850 DI 10.1177/0194599811400683 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 808SN UT WOS:000293998800003 PM 21493309 ER PT J AU Cook, MB Chia, VM Berndt, SI Graubard, BI Chanock, SJ Rubertone, MV Erickson, RL Hayes, RB McGlynn, KA AF Cook, Michael B. Chia, Victoria M. Berndt, Sonja I. Graubard, Barry I. Chanock, Stephen J. Rubertone, Mark V. Erickson, Ralph L. Hayes, Richard B. McGlynn, Katherine A. TI Genetic contributions to the association between adult height and testicular germ cell tumors SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Article DE Body height; case-control studies; epidemiology; polymorphism; single nucleotide; testicular neoplasms ID PROTEIN-COUPLED RECEPTORS; BODY-SIZE; PERINATAL VARIABLES; CANCER-EXPERIENCES; EUROPEAN COUNTRIES; RISK; BIRTH; SUSCEPTIBILITY; TRENDS; MEN AB Background Previously, we have shown that increasing adult height is associated with increased risk of testicular germ-cell tumor (TGCT). Recently, a number of single nucleotide polymorphisms (SNPs) have been found to be related to height. We examined whether these SNPs were associated with TGCT and whether they explained the relationship between height and TGCT. Methods We genotyped 15 height-related SNPs in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study. DNA was extracted from buccal cell samples and Taqman assays were used to type the selected SNPs. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs). Results There were 561 cases and 676 controls for analysis. Two SNPs were found to be associated with risk of TGCT, rs6060373 (CC vs TT, OR = 1.51, 95% CI: 1.06-2.15) and rs143384 (CC vs TT, OR = 1.53, 95% CI: 1.09-2.15). rs6060373 is an intronic polymorphism of ubiquinol-cytochrome c reductase complex chaperone (UQCC), and rs143384 is a 5'UTR polymorphism of growth differentiation factor 5 (GDF5). No individual SNP attenuated the association between height and TGCT. Adjustment for all SNPs previously associated with adult height reduced the associations between adult height and TGCT by similar to 8.5%, although the P-value indicated only weak evidence that this difference was important (P = 0.26). Conclusions This novel analysis provides tentative evidence that SNPs which are associated with adult height may also share an association with risk of TGCT. C1 [Cook, Michael B.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20852 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Cook, MB (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, 6120 Execut Blvd,EPS Suite 550,Room 5012, Bethesda, MD 20852 USA. EM cookmich@mail.nih.gov RI Cook, Michael/A-5641-2009; OI Cook, Michael/0000-0002-0533-7302; Hayes, Richard/0000-0002-0918-661X FU National Cancer Institute, National Institutes of Health, Department of Health and Human Services FX Intramural Program of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. NR 42 TC 6 Z9 6 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD JUN PY 2011 VL 40 IS 3 BP 731 EP 739 DI 10.1093/ije/dyq260 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 803YF UT WOS:000293618300024 PM 21233139 ER PT J AU Eze-Nliam, CM Quartana, PJ Quain, AM Smith, MT AF Eze-Nliam, Chete M. Quartana, Phillip J. Quain, Angela M. Smith, Michael T. TI Nocturnal Heart Rate Variability Is Lower in Temporomandibular Disorder Patients Than in Healthy, Pain-free Individuals SO JOURNAL OF OROFACIAL PAIN LA English DT Article DE autonomic dysfunction; chronic pain syndrome; heart rate variability; sympathetic hyperactivity; temporomandibular disorder ID RESEARCH DIAGNOSTIC-CRITERIA; SPECTRAL-ANALYSIS; SLEEP BRUXISM; FIBROMYALGIA; ASSOCIATION; DISEASE; RISK; MEN AB Aims: To determine whether patients with a painful myofascial temporomandibular disorder (TMD) have diminished nocturnal heart rate variability (HRV), a marker of autonomic nervous system (ANS) dysfunction, relative to healthy, pain-free controls. Methods: Participants with myofascial TMD and healthy, pain-free volunteers underwent nocturnal polysomnography studies during which HRV indices were measured. Multiple linear regression analyses were used to determine whether TMD status exerted unique effects on HRV. Results: Ninety-five participants (n = 37 TMD; n = 58 controls) were included in the analyses. The TMD group had a lower standard deviation of R-R intervals (89.81 +/- 23.54 ms versus 107.93 +/- 34.42 ms, P <= .01), a lower root mean squared successive difference (RMSSD) of R-R intervals (54.78 +/- 27.37 ms versus 81.88 +/- 46.43 ms, P < .01), and a lower high frequency spectral power (2336.89 +/- 1224.64 ms(2) versus 2861.78 +/- 1319 ms(2), P = .05) than the control group. The ratio of the low-frequency (LF) to the high-frequency (HF) spectral power was higher in the TMD group (2.47 +/- 2 versus 1.38 +/- 0.65, P < .01). The differences in RMSSD (91.21 ms versus 112.03 ms, P = .05) and LF:HF ratio (0.71 versus 0.32, P < .01) remained significant after controlling for age and psychological distress. Conclusion: Myofascial TMD patients revealed lower nocturnal HRV than healthy, pain-free controls. Further research should focus on processes that address this ANS imbalance, which may potentially lead to effective therapeutic interventions. J OROFAC PAIN 2011;25:232-239 C1 [Eze-Nliam, Chete M.; Quain, Angela M.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Ctr Mind Body Res, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Eze-Nliam, Chete M.] Johns Hopkins Univ, Sch Med, Johns Hopkins Bayview Med Ctr, Div Hosp Med, Baltimore, MD 21224 USA. RP Smith, MT (reprint author), Johns Hopkins Univ, Sch Med, Johns Hopkins Bayview Med Ctr, Dept Psychiat & Behav Sci, 5110 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. EM msmith62@jhmi.edu FU NINDS NIH HHS [K23 NS047168] NR 41 TC 12 Z9 12 U1 0 U2 4 PU QUINTESSENCE PUBLISHING CO INC PI HANOVER PARK PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA SN 1064-6655 J9 J OROFAC PAIN JI J. Orofac. Pain PD SUM PY 2011 VL 25 IS 3 BP 232 EP 239 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 801ZM UT WOS:000293479100006 PM 21837290 ER PT J AU Gross, CL Nealley, EW Miller, AL Nipwoda, MT Clark, OE Smith, WJ AF Gross, Clark L. Nealley, Eric W. Miller, Adele L. Nipwoda, Mary T. Clark, Offie E. Smith, William J. TI Effect of Ebselen in Modulating Genotoxicity in Cultured Human Cells from Chloroethyl Ethyl Sulfide Exposure Using Comet Assay Analysis SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Gross, Clark L.; Nealley, Eric W.; Miller, Adele L.; Nipwoda, Mary T.; Clark, Offie E.; Smith, William J.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM clark.gross@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUN PY 2011 VL 47 SU 1 BP S44 EP S45 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 799IZ UT WOS:000293281700104 ER PT J AU Yeh, GT Shih, DS Cheng, JRC AF Yeh, Gour-Tsyh Shih, Don-Sin Cheng, Jing-Ru C. TI An integrated media, integrated processes watershed model SO COMPUTERS & FLUIDS LA English DT Article DE Watershed modelling; Groundwater and surface water coupling; High performance parallel computing; River hydraulics; Surface runoff; Groundwater flow; St. Venant equations ID SYSTEME HYDROLOGIQUE EUROPEEN; SHE AB Parametric-based, lumped watershed models have been widely employed for integrated surface and groundwater modelling to calculate surface runoff on various temporal and spatial scales of hydrologic regimes. Physics-based, process-level, distributed models that have the design capability to cover multimedia and multi-processes and are applicable to various scales have been practically nonexistent until late 1990s. It has long been recognized that only such models have the potential to further the understanding of the fundamental factors that take place in nature hydrologic regimes: to give mechanistic predictions; and most importantly to be able to couple and interact with weather/climate models. However, there are severe limitations with these models that inhibit their use. These are, among other things, the ad hoc approaches of coupling between various media, the simplification of modelling overland and/or river flow, and the excessive demand of computational time. This paper presents the development of an integrated media (river/stream networks, overland regime, and subsurface media), integrated processes (evaporation, evapotranspiration, infiltration, recharges, and flows) watershed model to address these issues. Rigorous coupling strategies are described for interactions among overland regime, rivers/streams/canals networks, and subsurface media. The necessities to include various options in modelling surface runoff and river hydraulics are emphasized. The options of selecting characteristic wave directions for two-dimensional problems are stated. The implementation of high performance computing to increase the computational speed is discussed. Four examples are used to demonstrate the flexibility and efficiency of the model as applied to a theoretical benchmark scale, a parallel computing, and two project-level large scale problems - one in Taiwan and the other in Florida. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Yeh, Gour-Tsyh] Natl Cent Univ, Tao Yuan 32001, Taiwan. [Shih, Don-Sin] Taiwan Typhoon & Flood Res Inst, Taichung 407, Taiwan. [Cheng, Jing-Ru C.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Yeh, GT (reprint author), Natl Cent Univ, Tao Yuan 32001, Taiwan. EM gyeh@mail.ucf.edu; dsshih@narl.org.tw; Ruth.C.Cheng@usace.army.mil FU National Science Council with National Central University with Taiwan Typhoon Flood Research Institute (TTFRI), National Applied Research Laboratory, Taiwan [NSC 99-2116-M-008-020, NSC 99-1903-02-05-03] FX Research is supported by National Science Council, in part, under Contract No. NSC 99-2116-M-008-020 with National Central University and, in part, under Contract No. NSC 99-1903-02-05-03 with Taiwan Typhoon Flood Research Institute (TTFRI), National Applied Research Laboratory, Taiwan. NR 29 TC 19 Z9 19 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7930 J9 COMPUT FLUIDS JI Comput. Fluids PD JUN PY 2011 VL 45 IS 1 SI SI BP 2 EP 13 DI 10.1016/j.compfluid.2010.11.018 PG 12 WC Computer Science, Interdisciplinary Applications; Mechanics SC Computer Science; Mechanics GA 796FL UT WOS:000293037100002 ER PT J AU Mittendorf, EA Alatrash, G Xiao, HL Clifton, GT Murray, JL Peoples, GE AF Mittendorf, Elizabeth A. Alatrash, Gheath Xiao, Haile Clifton, G. Travis Murray, James L. Peoples, George E. TI Breast cancer vaccines: ongoing National Cancer Institute-registered clinical trials SO EXPERT REVIEW OF VACCINES LA English DT Review DE breast cancer; clinical trials; immunotherapy; vaccines ID COLONY-STIMULATING FACTOR; PHASE-I TRIAL; LARGE MULTIVALENT IMMUNOGEN; REGULATORY T-CELLS; GROUP-STUDY I-01; MHC CLASS-I; DENDRITIC CELLS; ANTITUMOR IMMUNITY; PANCREATIC-CANCER; PROSTATE-CANCER AB Advances in the molecular characterization of human tumors have led to increased interest in the development of targeted therapeutics to include cancer vaccines. The recent success of sipuleucel-T, an autologous cellular vaccine administered to patients with hormone-refractory metastatic prostate cancer, suggests that this is a viable therapeutic option in the management of patients with solid tumors. This article focuses on breast cancer vaccines emphasizing delivery platforms, target antigens and novel strategies designed to enhance response to vaccination that are being evaluated in ongoing Phase II clinical trials. C1 [Clifton, G. Travis; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Mittendorf, Elizabeth A.; Xiao, Haile] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Alatrash, Gheath] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Houston, TX 77030 USA. [Murray, James L.] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. EM george.peoples@us.army.mil OI Alatrash, Gheath/0000-0002-7648-4377 NR 129 TC 9 Z9 9 U1 0 U2 5 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD JUN PY 2011 VL 10 IS 6 SI SI BP 755 EP 774 DI 10.1586/ERV.11.59 PG 20 WC Immunology SC Immunology GA 797HT UT WOS:000293115800013 PM 21692698 ER PT J AU Harms, N Grodowitz, M Kennedy, J AF Harms, Nathan Grodowitz, Michael Kennedy, James TI Insect herbivores of water stargrass (Heteranthera dubia) in the US SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article DE aquatic plants; herbivory; water stargrass; Heteranthera dubia ID VALLISNERIA-AMERICANA; HYDRILLA-VERTICILLATA; MYRIOPHYLLUM-SPICATUM; GENUS NECTOPSYCHE; NORTH-AMERICA; IMPACT AB We examined insect herbivores associated with Heteranthera dubia from surveys conducted from 2006 to 2009. Plants were collected, invertebrates were removed, and signs of feeding damage were noted. Herbivores were quantified, and geographic regions were compared based on herbivore density, taxa richness, evenness, and diversity. The greatest density of herbivores occurred at Parker Pond, Washington, which was largely influenced by an abundance of aphids (Rhopalosiphum spp.). Density, richness, and evenness were not significantly different among regions. At least 23 potential insect herbivores were recorded from 15 sites in Texas, Washington, Minnesota, Wisconsin, Vermont, and New York. Of these, five taxa were collected from the order Lepidoptera, one from Coleoptera, six from Diptera, and at least 11 from Trichoptera. The majority of the herbivores were generalists; several had unknown diets. Damage observed to H. dubia included extensive tunneling in the stems of the plant and, in some cases, substantial chewing damage to the leaves. C1 [Harms, Nathan; Grodowitz, Michael] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kennedy, James] Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA. RP Harms, N (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM nathan.e.harms@usace.army.mil NR 30 TC 2 Z9 2 U1 1 U2 2 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 USA SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 2011 VL 26 IS 2 BP 185 EP 194 DI 10.1080/02705060.2011.554217 PG 10 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 795CN UT WOS:000292949200005 ER PT J AU Gumz, JE AF Gumz, Jonathan E. TI The Cognitive Challenge of War: Prussia, 1806 SO JOURNAL OF MODERN HISTORY LA English DT Book Review C1 [Gumz, Jonathan E.] US Mil Acad, West Point, NY 10996 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-2801 J9 J MOD HIST JI J. Mod. Hist. PD JUN PY 2011 VL 83 IS 2 BP 454 EP 455 DI 10.1086/659191 PG 4 WC History SC History GA 794YM UT WOS:000292937400041 ER PT J AU Lande, RG Williams, LB Gragnani, C Tsai, A AF Lande, R. Gregory Williams, Lisa Banks Gragnani, Cynthia Tsai, Albert TI Effectiveness of light therapy for depression among active duty service members: A nonrandomized controlled pilot trial SO COMPLEMENTARY THERAPIES IN MEDICINE LA English DT Article DE Light therapy; Depression; Military ID SEASONAL AFFECTIVE-DISORDER; NONSEASONAL MAJOR DEPRESSION; ADJUNCTIVE BRIGHT LIGHT; SPECTRUM; SYMPTOM; SCALES AB Objective: The authors investigated the potential effectiveness of light therapy as an augmentation treatment for depression among active duty service members. Design: This pilot study recruited active duty service members deployed to an area of combat operations. Enrollment was offered to service members scoring 50 or greater on the Zung Self-Rating Depression Scale. The authors implemented a systematic sampling technique randomly assigning the first subject and then alternating each subsequent subject to either a reference group which received the usual standard of care plus light therapy at 10,000 lux or a control group which received the usual standard of care and light therapy at 50 lux. Both groups received 90 min light sessions for five days. Setting: The study was conducted at Walter Reed Army Medical Center's Psychiatry Continuity Service. Main Outcome Measure: Zung Self-Rating Depression Scale collected at baseline, after five consecutive daily light sessions, and one week later. Results: A repeated measures analysis of variance (RM ANOVA) was conducted to examine the change in Zung Depression results which showed a significant main effect for time F(2, 21) = 5.05, p < 0.02, indicating that depression scores reduced over time for both participant groups. Post hoc comparisons (with Bonferroni correction) demonstrated that the post-treatment Zung score was significantly lower indicating less depression than the baseline Zung score (p < 0.004) and there was a statistical trend (p < 0.05) for depression scores to be reduced halfway through the study in the treatment group. Conclusion: The post hoc analysis hints at the possibility of a reduction in depression during the active phase of light treatment. (C) 2011 Published by Elsevier Ltd C1 [Lande, R. Gregory; Williams, Lisa Banks; Gragnani, Cynthia; Tsai, Albert] Walter Reed Army Med Ctr, Psychiat Continu Serv, Dept Psychiat, Washington, DC 20307 USA. RP Lande, RG (reprint author), Walter Reed Army Med Ctr, Psychiat Continu Serv, Dept Psychiat, Washington, DC 20307 USA. EM rglande@act85.com NR 21 TC 3 Z9 3 U1 1 U2 8 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0965-2299 J9 COMPLEMENT THER MED JI Complement. Ther. Med. PD JUN PY 2011 VL 19 IS 3 BP 161 EP 163 DI 10.1016/j.ctim.2011.04.003 PG 3 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 789AN UT WOS:000292485800009 PM 21641522 ER PT J AU Ake, J Scott, P Wortmann, G Huang, XZ Barber, M Wang, ZN Nikolich, M Van Echo, D Weintrob, A Lesho, E AF Ake, Julie Scott, Paul Wortmann, Glenn Huang, Xiao-Zhe Barber, Melissa Wang, Zhining Nikolich, Mikeljon Van Echo, David Weintrob, Amy Lesho, Emil TI Gram-Negative Multidrug-Resistant Organism Colonization in a US Military Healthcare Facility in Iraq SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ACINETOBACTER-BAUMANNII OUTBREAK; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; INFECTIONS; UNIT; RECOVERY; BACTERIA; TIME AB OBJECTIVE. To investigate potential sources of gram-negative multidrug-resistant organisms (MDROs) in a deployed US military healthcare facility. DESIGN. Active surveillance. METHODS. Swab sampling of patients, hospital personnel, and environmental surfaces was performed before the opening of a new medical treatment facility in Iraq and then serially for the next 6 months. Multidrug resistant isolates were genotypically characterized using pulsed-field gel electrophoresis (PFGE). Univariate and multivariate analysis were performed to evaluate associations between patient characteristics and MDRO carriage. SETTING. Deployed US military medical facility RESULTS. A total of 1,348 samples were obtained, yielding 654 isolates, 42 of which were MDROs. One hundred fifty-eight patients were sampled; swabs from 18 patients yielded 29 MDR isolates. Host nation patients comprised 89% of patients with MDROs and 37% of patients without MDROs (P < .001). Host nation patient status was also significantly associated with MDRO carriage in multivariate logistic regression analysis (adjusted odds ratio, 2.9; confidence interval, 1.3-6.3; P = .009). Bacteria with PFGE patterns matching those recovered from host nation patients were later isolated from environmental surfaces including recovery room patient monitors and the trauma bay floor. CONCLUSIONS. At this facility, MDRO isolation was predominantly obtained from newly admitted host nation patients, which may reflect baseline colonization with MDROs in the community. Patient MDRO carriage was linked to subsequent environmental contamination. These findings support intensive infection control efforts in forward deployed facilities. Infect Control Hosp Epidemiol 2011;32(6):545-552 C1 [Ake, Julie; Scott, Paul; Wang, Zhining] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. [Ake, Julie; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Huang, Xiao-Zhe; Nikolich, Mikeljon; Lesho, Emil] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Barber, Melissa; Weintrob, Amy] USU Infect Dis Clin Res Program, Bethesda, MD USA. [Van Echo, David] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. RP Ake, J (reprint author), Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM jake@hivresearch.org FU US Department of Defense FX Funding was provided by the US Department of Defense Global Emerging Infections Surveillance and Response System. NR 24 TC 12 Z9 12 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUN PY 2011 VL 32 IS 6 BP 545 EP 552 DI 10.1086/660015 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 791GQ UT WOS:000292653500003 PM 21558766 ER PT J AU Sabol, JV Grant, GT Liacouras, P Rouse, S AF Sabol, Jennifer V. Grant, Gerald T. Liacouras, Peter Rouse, Stephen TI Digital Image Capture and Rapid Prototyping of the Maxillofacial Defect SO JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY LA English DT Article DE Moulage; stereolithography; 3dMDface ID PRECISION; ACCURACY AB In order to restore an extraoral maxillofacial defect, a moulage impression is commonly made with traditional impression materials. This technique has some disadvantages, including distortion of the site due to the weight of the impression material, changes in tissue location with modifications of the patient position, and the length of time and discomfort for the patient due to the impression procedure and materials used. The use of the commercially available 3dMDface (TM) System creates 3D images of soft tissues to form an anatomically accurate 3D surface image. Rapid prototyping converts the virtual designs from the 3dMDface (TM) System into a physical model by converting the data to a ZPrint (ZPR) CAD format file and a stereolithography (STL) file. The data, in conjunction with a Zprinter (R) 450 or a Stereolithography Apparatus (SLA), can be used to fabricate a model for prosthesis fabrication, without the disadvantages of the standard moulage technique. This article reviews this technique and how it can be applied to maxillofacial prosthetics. C1 [Sabol, Jennifer V.] Walter Reed Army Med Ctr, Dept Prosthodont, Washington, DC 20307 USA. [Grant, Gerald T.] Natl Naval Med Ctr, Dept Maxillofacial Prosthet, Bethesda, MD USA. [Liacouras, Peter; Rouse, Stephen] Walter Reed Army Med Ctr, Dept Modeling 3D, Washington, DC 20307 USA. RP Sabol, JV (reprint author), Walter Reed Army Med Ctr, Dept Prosthodont, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jsabol1019@hotmail.com FU National Naval Medical Center, Bethesda, MD FX Supported in part by the National Naval Medical Center, Bethesda, MD NR 7 TC 11 Z9 12 U1 1 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1059-941X J9 J PROSTHODONT JI J. Prosthodont. PD JUN PY 2011 VL 20 IS 4 BP 310 EP 314 DI 10.1111/j.1532-849X.2011.00701.x PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 788XO UT WOS:000292477900011 PM 21438958 ER PT J AU McGeary, DD AF McGeary, Donald D. TI Making Sense of Resilience SO MILITARY MEDICINE LA English DT Editorial Material ID TRAUMA C1 Brooke Army Med Ctr, Warrior Resiliency Program, San Antonio, TX 78230 USA. RP McGeary, DD (reprint author), Brooke Army Med Ctr, Warrior Resiliency Program, 7800 IH-10 W,Suite 300, San Antonio, TX 78230 USA. NR 7 TC 7 Z9 7 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 603 EP 604 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800004 PM 21702373 ER PT J AU Shelley, JJ McQuistan, MR Delacruz, G Marshall, TA Momany, ET AF Shelley, Johnette Joy McQuistan, Michelle R. Delacruz, Georgia Marshall, Teresa A. Momany, Elizabeth T. TI Significant Indicators of Intent to Leave Among Army Dental Corps Junior Officers SO MILITARY MEDICINE LA English DT Article ID TURNOVER INTENTIONS; EMPLOYEE TURNOVER; METAANALYSIS; RETENTION; PERSONNEL; MILITARY AB Objective: To identify the significant predictors associated with Army Dental Corps junior officers' intent to leave (ITL) the military. Methods: A secondary data analysis of the 2009 Army Dental Officer Retention Survey was conducted. Frequencies, bivariate, linear, and logistic regression analyses were calculated. Results: Forty-six percent of junior officers completed the survey (N = 577; n = 267). Fifty-eight percent of respondents reported an ITL the military before retirement. The following variables were positively associated (p < 0.05) with ITL: unit of assignment, specialty training status or area of concentration, military lifestyle, and residency training. Age and benefits were negatively associated with ITL. Conclusion: This study suggests that ITL is a multifactorial issue. C1 [Shelley, Johnette Joy] USA, DENTAC, Ft Hood, TX 76544 USA. [McQuistan, Michelle R.] Univ Iowa, Coll Dent, Dept Prevent & Community Dent, Iowa City, IA 52242 USA. [Delacruz, Georgia] Dent Corps Branch, Off Army Surg Gen, Falls Church, VA 22020 USA. [Marshall, Teresa A.] Univ Iowa, Coll Dent, Dept Prevent & Community Dent, Iowa City, IA 52241 USA. [Momany, Elizabeth T.] Univ Iowa, Publ Policy Ctr, Iowa City, IA 52242 USA. RP Shelley, JJ (reprint author), USA, DENTAC, Bldg 4431 68th St, Ft Hood, TX 76544 USA. NR 35 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 631 EP 638 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800010 PM 21702379 ER PT J AU Miller, MA Hall, BT Agyapong, F Kelly, KJ McArthur, T AF Miller, Michael A. Hall, Brian T. Agyapong, Francis Kelly, Kenneth J. McArthur, Todd TI Traumatic Noncombat-Related Hand Injuries in US Troops in the Combat Zone SO MILITARY MEDICINE LA English DT Article ID OCCUPATIONAL INJURIES; CASE-CROSSOVER; AMPUTATIONS; WORK AB Background: The epidemiology of traumatic, nonbattle, Combat Zone hand injuries has not been well explored. Methods: This was a retrospective chart review of Emergency Department visits occurring at the Ibn Sina Hospital in Baghdad Iraq. Results: During the 24-month period from May 2007 to June 2009, 7,520 patients were seen at the Ibn Sina Hospital Emergency Department. Three hundred thirty-one cases met the inclusion criteria. Seventy-four cases were found to have required near-term evacuation from area of operation. Conclusions: Traumatic, nonbattle hand injuries are common and appear to be a significant problem in the Combat Zone. Injuries occurring because of the closure of vehicle doors, hatches, and turrets make up a large portion of these injuries and represent an optimal area of intervention for possible injury mitigation. C1 [Miller, Michael A.; Kelly, Kenneth J.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. [Hall, Brian T.] CR Darnall Army Med Ctr, Dept Emergency Med, Ft Hood, TX 76542 USA. [Agyapong, Francis] 10th Combat Support Hosp, Ft Carson, CO 80913 USA. [McArthur, Todd] Madigan Army Med Ctr, Dept Emergency Med, Ft Lewis, WA 98431 USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 21 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 652 EP 655 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800013 PM 21702382 ER PT J AU Devore, DI Walters, TJ Christy, RJ Rathbone, CR Hsu, JR Baer, DG Wenke, JC AF Devore, David I. Walters, Thomas J. Christy, Robert J. Rathbone, Christopher R. Hsu, Joseph R. Baer, David G. Wenke, Joseph C. TI For Combat Wounded: Extremity Trauma Therapies From the USAISR SO MILITARY MEDICINE LA English DT Article ID ENDURING FREEDOM; CASUALTIES; IRAQI; MODEL C1 [Devore, David I.; Walters, Thomas J.; Christy, Robert J.; Rathbone, Christopher R.; Hsu, Joseph R.; Baer, David G.; Wenke, Joseph C.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Devore, DI (reprint author), USA, Inst Surg Res, San Antonio, TX 78234 USA. FU USAMRMC, Fort Detrick, MD FX Funding for the project was provided by the USAMRMC, Fort Detrick, MD. NR 17 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 660 EP 663 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800015 PM 21702384 ER PT J AU Andrews, AM Wunderlich, B Linberg, A AF Andrews, Anne M. Wunderlich, Benjaman Linberg, Alison TI Core Temperature Changes in Service Members With and Without Amputations During the Army 10-Miler SO MILITARY MEDICINE LA English DT Article ID TRANS-TIBIAL AMPUTEES; LOWER-LIMB AMPUTATION; X-RAY ABSORPTIOMETRY; BODY-COMPOSITION; ENERGY-EXPENDITURE; HEAT; EXERCISE; PERFORMANCE; PARTICIPATION; AMBULATION AB The purpose of this case study was to assess differences in core temperature between individuals with and without amputations during a 10-mile run. Decreased body surface area and increased energy needs for ambulation may increase heat production and risk of heat injury for individuals with amputations. Two runners, 1 with and 1 without amputation, completed a 10-mile road race. Anthropometrics, body composition, and energy expenditure were collected before the run. Core temperature and activity were measured continually during the event. Maximum core temperature for the runner with amputation was 38.4 degrees C and for the runner without amputation was 37.9 degrees C. Despite the higher temperature, the runner with amputation completed the run at a slower pace than the one without amputation, indicating that higher core body temperatures may be achieved in individuals with amputation at similar workloads. These data suggest that future research is needed to elucidate differences in core temperature in individuals with amputations. C1 [Andrews, Anne M.; Linberg, Alison] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Wunderlich, Benjaman] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Andrews, AM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. FU Military Amputee Research Program FX The authors thank the Service Members who volunteered for this study. Funding for this study was provided by the Military Amputee Research Program. NR 29 TC 2 Z9 2 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 664 EP 668 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800016 PM 21702385 ER PT J AU Freeman, RJ Cersovsky, SB Barbour, G AF Freeman, Randall J. Cersovsky, Steven B. Barbour, Galen TI An Evaluation of the Delivery of Clinical Preventive Services in the Joint Task Force National Capital Region Medical SO MILITARY MEDICINE LA English DT Article AB The Walter Reed Army Institute of Research General Preventive Medicine Residency conducted a performance improvement study to evaluate clinical preventive services (CPSs) in the National Capital Region. This study focused on enhancing medical care through quality management of both the process and measurement of service delivery, thereby improving the overall quality of a service by examining its constituent parts. Screening mammography and pneumococcal immunization were the CPSs selected for evaluation, and 9 of 40 military treatment facilities (MTFs) were visited. Mammography completion ranged from 64% to 81%. The process of providing mammography to eligible enrollees varied greatly among MTFs, and the majority did not utilize all identified steps deemed critical for mammography completion. Pneumococcal immunization ranged from 0% to 21%. There was a positive correlation between CPS completion, the number of eligible enrollees, and the use of critical steps. Recommendations include using critical steps to evaluate and improve MTFs' CPS processes. C1 [Freeman, Randall J.] Bassett Army Community Hosp, Dept Prevent Med, Ft Wainwright, AK 99703 USA. [Cersovsky, Steven B.] USA, Publ Hlth Command Provis, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Barbour, Galen] Uniformed Serv Univ Hlth Sci, Hlth Serv Adm, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Freeman, RJ (reprint author), Bassett Army Community Hosp, Dept Prevent Med, Bldg 4077,1060 Gaffney Rd, Ft Wainwright, AK 99703 USA. FU Walter Reed Army Institute of Research (WRAIR) FX This study was funded by the Walter Reed Army Institute of Research (WRAIR) Preventive Medicine Residency Program. NR 15 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 679 EP 684 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800019 PM 21702388 ER PT J AU George, S Jackson, JL Passamonti, M AF George, Susan Jackson, Jeffrey L. Passamonti, Mark TI Complementary and Alternative Medicine in a Military Primary Care Clinic: A 5-Year Cohort Study SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES; PREDICTORS; PREVALENCE; THERAPIES; SYMPTOMS; HEADACHE; PATTERNS; CAM AB Previous studies have found that complementary and alternative medication (CAM) use is common. We enrolled 500 adults presenting to a primary care military clinic. Subjects completed surveys before the visit, immediately afterwards, at 2 weeks, 3 months, and 5 years. Over 5 years, 25% used CAM for their presenting symptom. Most (72%) reported that CAM helped their symptom. Independent predictors of CAM use included female sex (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.1-3.7), college educated (OR, 3.4; 95% CI, 1.8-6.3), more severe symptoms (OR, 1.14; 95% CI, 1.01-1.28), and persistence of symptom beyond 3 months (OR, 3.9; 95% CI, 2.0-7.5). We concluded that a quarter of military primary care patients use CAM over 5 years of follow-up and most find it helpful. CAM users tend to be female and better educated. Patients with more severe symptoms or symptoms that persist beyond 3 months are also more likely to turn to CAM. C1 [George, Susan; Jackson, Jeffrey L.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Passamonti, Mark] Winn Army Community Hosp, Internal Med Serv, Ft Stewart, GA 31314 USA. RP George, S (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 24 TC 2 Z9 2 U1 4 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 685 EP 688 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800020 PM 21702389 ER PT J AU Montgomery, JR Carroll, RB McCollum, AM AF Montgomery, Jay R. Carroll, Robert B. McCollum, Andrea M. TI Ocular Vaccinia: A Consequence of Unrecognized Contact Transmission SO MILITARY MEDICINE LA English DT Article ID SMALLPOX VACCINATION; SEXUAL CONTACT; COMPLICATIONS; INFECTION; THERAPY AB A patient developed severe ocular vaccinia via autoinoculation after acquiring unrecognized contact-transmitted vaccinia from wrestling with vaccinated members of his unit. This case highlights both the need to reinforce infection-control measures among vaccinees and the need for providers to be familiar with the identification and treatment of cutaneous and ocular vaccinia infection. C1 [Montgomery, Jay R.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20012 USA. [Carroll, Robert B.] Womack Army Med Ctr, Dept Ophthalmol, Ft Bragg, NC 28310 USA. [McCollum, Andrea M.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. RP Montgomery, JR (reprint author), Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, 6900 Georgia Ave NW,Buillding 41,Room 21, Washington, DC 20012 USA. NR 15 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 699 EP 701 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800023 PM 21702392 ER PT J AU Aldous, WK Robertson, JL Robinson, BJ Hatcher, CL Hospenthal, DR Conger, NG Murray, CK AF Aldous, Wade K. Robertson, Janelle L. Robinson, Brian J. Hatcher, Christopher L. Hospenthal, Duane R. Conger, Nicholas G. Murray, Clinton K. TI Rates of Gonorrhea and Chlamydia in US Military Personnel Deployed to Iraq and Afghanistan (2004-2009) SO MILITARY MEDICINE LA English DT Article ID NEISSERIA-GONORRHOEAE; UNITED-STATES; HEALTH-CARE; OPERATION; DISEASE; SOLDIERS; FREEDOM; ARMY AB The increased incidence of sexually transmitted infections has historically been associated with military personnel at war. The incidence of gonorrhea and Chlamydia in personnel deployed in the current wars in Iraq and Afghanistan has not been reported. An electronic records' review of testing done from January 2004 to September 2009 revealed higher rates of Chlamydia than gonorrhea, especially among females who deploy to Iraq. Additionally, increasing Chlamydia rates were noted over the study. Overall, the rates of gonorrhea and Chlamydia were the same or lower than age- and year-matched U.S. rates reported by the Center for Disease Control and Prevention. Ongoing education with emphasis on prevention and treatment are needed, as are development of specific projects to define the risk factors and timing of acquisition of sexually transmitted infections in combat zones. C1 [Aldous, Wade K.; Robertson, Janelle L.; Robinson, Brian J.; Hatcher, Christopher L.; Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Robertson, Janelle L.; Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Conger, Nicholas G.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Aldous, WK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 21 TC 11 Z9 12 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2011 VL 176 IS 6 BP 705 EP 710 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 792XN UT WOS:000292783800025 PM 21702394 ER PT J AU Krishnan, R Riley, M Lee, S Lu, TM AF Krishnan, Rahul Riley, Michael Lee, Sabrina Lu, Toh-Ming TI Formation of biaxially textured molybdenum thin films under the influence of recrystallization conditions SO THIN SOLID FILMS LA English DT Article DE Molybdenum; Glancing angle deposition; Biaxial texture; Diffraction ID SPUTTERED MOLYBDENUM; DEPOSITION; POLYCRYSTALLINE; ALIGNMENT; EVOLUTION AB This article highlights the formation of biaxially textured body centered cubic Mo nanorods under recrystallization conditions using glancing angle deposition. The flux incidence angle has been changed (alpha =0 degrees, 70 degrees and 85 degrees away from the surface normal) to observe its effect on the formation of biaxial texture under a constant low Ar pressure environment (0.306 Pa). Only at a glancing flux incidence (alpha=85 degrees). the directional diffusion overcomes the effect of recrystallization to yield a highly biaxial texture. In another study, a normal flux incidence (alpha=0 degrees) was kept constant and the Ar pressure was changed (0.67, 1.33 and 2.67 Pa) to see its influence on the film morphology and the resulting texture. The Ar pressure variation was aimed at attempting a zone transformation in accordance with the structure zone model. While the morphology appeared to agree with the expected zone transformation, the texture did not. (C) 2011 Elsevier B.V. All rights reserved. C1 [Krishnan, Rahul] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Riley, Michael] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA. [Lee, Sabrina] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. [Lu, Toh-Ming] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. RP Krishnan, R (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM krishr2@rpi.edu FU NSF NIRT [0506738] FX This work was supported by NSF NIRT 0506738. We thank Dr. D. Depla for the valuable discussions. NR 15 TC 4 Z9 4 U1 1 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD JUN 1 PY 2011 VL 519 IS 16 BP 5429 EP 5432 DI 10.1016/j.tsf.2011.02.048 PG 4 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 790FI UT WOS:000292573500020 ER PT J AU Walker, MR Ernest, AJ McMann, LP AF Walker, Marc R. Ernest, Alexander J., Jr. McMann, Leah P. TI Hydrocele: an atypical presentation of metastatic sarcomatoid renal cell carcinoma SO CANADIAN JOURNAL OF UROLOGY LA English DT Article DE epididymitis; hydrocele; metastatic; pyocele; sarcomatoid; renal cell carcinoma AB Herein is a case of a 55-year-old man who presented with epididymitis. He subsequently failed medical management for the suspected infection and progressed to develop an acute scrotum and sonographic findings consistent with a pyocele. Concurrent computed tomography (CT), obtained for persistent abdominal pain, revealed a large enhancing upper pole renal mass suspicious for malignancy. He was taken for emergent scrotal exploration to drain the presumptive pyocele. However, during scrotal exploration, no purulence or evidence of infection was seen. Although, seemingly unrelated to the renal mass, the thickened hydrocele sac was excised and sent as a specimen. Pathology of the sac revealed a diagnosis of metastatic sarcomatoid renal cell carcinoma. Appropriate chemotherapy was initiated based on the scrotal pathology, circumventing the need for a CT directed retroperitoneal lymph node biopsy or nephrectomy. C1 [Walker, Marc R.; Ernest, Alexander J., Jr.; McMann, Leah P.] Tripler Army Med Ctr, Urol Serv, Dept Surg, Honolulu, HI 96859 USA. RP Walker, MR (reprint author), Tripler Army Med Ctr, Urol Serv, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU CANADIAN J UROLOGY PI ST LAURENT PA 2330 WARD ST, STE 604, ST LAURENT, QUEBEC H4M 2V6, CANADA SN 1195-9479 J9 CAN J UROL JI Can. J. Urol. PD JUN PY 2011 VL 18 IS 3 BP 5742 EP 5744 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 788HS UT WOS:000292436600018 PM 21703053 ER PT J AU Nindl, BC Santtila, M Vaara, J Hakkinen, K Kyrolainen, H AF Nindl, Bradley C. Santtila, Matti Vaara, Jani Hakkinen, Keijo Kyrolainen, Heikki TI Circulating IGF-I is associated with fitness and health outcomes in a population of 846 young healthy men SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE IGF-I; Biomarker; Population-based study ID GROWTH-FACTOR-I; PHYSICAL-ACTIVITY; BODY-COMPOSITION; BINDING-PROTEINS; MUSCLE STRENGTH; ELDERLY-MEN; FACTOR AXIS; WOMEN; HORMONE; AGE AB Context: Insulin-like growth factor-I (IGF-I) is thought to mediate many of the beneficial outcomes of physical activity. While IGF-I has previously been shown to be positively related with aerobic fitness, few studies have examined IGF-I relationships with other fitness and health parameters. The robustness of IGF-las a biomarker of fitness and health has yet to be fully determined. Objective: To determine the association of circulating IGF-I with fitness, body composition and health parameters in young, healthy men. Design and subjects: A cross-section of 846 young, healthy Finnish men (25 +/- 5 yr. 180 +/- 6 cm, 81 +/- 13 kg). Subjects were divided into quintiles of IGF-I concentrations (Q1: lowest; Q5: highest) for statistical evaluation. Main outcome measures: Circulating IGF-I, physical fitness: peak aerobic capacity (VO(2) peak), maximal strength of leg and arm extensors, muscle endurance (sit-ups, push-ups, and repetitive squats) and health outcome parameters (total blood cholesterol, triglyceride, high-density lipoproteins (HDL), low-density lipoproteins (LDL), systolic and diastolic blood pressure, waist circumference, % body fat, and drinking, smoking and physical activity behavior). Results: Higher IGF-I was associated with higher VO(2) peak (Q1: 39 +/- 7 vs. Q5: 44 9 mL/kg/min), sit-ups (Q1: 35 +/- 10 vs. Q5: 41 +/- 10 repetitions), push-ups (Q1 : 27 +/- 13 vs. Q5: 31 +/- 14 repetitions), repetitive squats (Q2: 42 10 vs. Q5: 45 8 repetitions), HDL (Q1: 1.5 +/- 0.4 vs. Q5: 1.53 +/- 0.3 mmol/L), and lower age (Q1: 28 +/- 6 vs. Q5: 23 +/- 2 yr), %BF (Ql: 20 +/- 7 vs. Q5: 16 +/- 6%BF), waist circumference (Q1: 89 +/- 11 vs. Q5: 84 +/- 9 cm), BMI (Q1 : 25.6 +/- 4 vs. Q5: 24.3 m(2)/kg), diastolic blood pressure (Q1: 78.5 +/- 9 vs. Q5: 75.4 +/- 8 mm Hg), cholesterol (Q1: 4.72 +/- 0.9 vs. Q5: 4.44 +/- 0.8 mmol/L) and smoking (Q1: 44% vs. Q5: 32%). No association was observed for IGF-I and maximal leg extension (Q1: 2982 +/- 927 vs. Q5: 2932 +/- 853N) and bench press (Q1: 895 197 vs. Q5: 919 +/- 203 N) strength, fat-free mass (Q1: 64.6 +/- 8 vs. Q5: 66.6 +/- 7 KG), LDL (2.54 +/- 0.7 vs. Q5: 2.35 +/- 0.6 mmol/L), or triglycerides (Q1: 1.05 +/- 0.6 vs. Q5: 0.99 +/- 0.5 mmol/L). Conclusion: IGF-I is positively associated with aerobic fitness and muscular endurance, but not with measures of muscle strength or FFM. IGF-I is positively associated with improved health and fitness outcomes in young, healthy men. Published by Elsevier Ltd. on behalf of Growth Hormone Research Society. C1 [Nindl, Bradley C.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Santtila, Matti] Finnish Def Forces, Personnel Div, Def Command, Helsinki, Finland. [Vaara, Jani; Kyrolainen, Heikki] Natl Def Univ, Helsinki, Finland. [Vaara, Jani; Hakkinen, Keijo; Kyrolainen, Heikki] Univ Jyvaskyla, Dept Biol Phys Act, Neuromuscular Res Ctr, Jyvaskyla, Finland. RP Nindl, BC (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil NR 33 TC 15 Z9 16 U1 0 U2 4 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD JUN PY 2011 VL 21 IS 3 BP 124 EP 128 DI 10.1016/j.ghir.2011.03.001 PG 5 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 788IU UT WOS:000292439400002 PM 21459641 ER PT J AU Brophy, GM Mondello, S Papa, L Robicsek, SA Gabrielli, A Tepas, J Buki, A Robertson, C Tortella, FC Hayes, RL Wang, KKW AF Brophy, Gretchen M. Mondello, Stefania Papa, Linda Robicsek, Steven A. Gabrielli, Andrea Tepas, Joseph, III Buki, Andras Robertson, Claudia Tortella, Frank C. Hayes, Ronald L. Wang, Kevin K. W. TI Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarkers; clinical trial; neural injury; outcome measures; traumatic brain injury ID NEURON-SPECIFIC ENOLASE; BIOMARKER; PROGESTERONE; RATS AB Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were to determine UCH-L1 exposure and kinetic metrics, determine correlations between biofluids, and assess outcome correlations in severe TBI patients. Data were analyzed from a prospective, multicenter study of severe TBI (Glasgow Coma Scale [GCS] score <= 8). Cerebrospinal fluid (CSF) and serum data from samples taken every 6 h after injury were analyzed by enzyme-linked immunosorbent assay (ELISA). UCH-L1 CSF and serum data from 59 patients were used to determine biofluid correlations. Serum samples from 86 patients and CSF from 59 patients were used to determine outcome correlations. Exposure and kinetic metrics were evaluated acutely and up to 7 days post-injury and compared to mortality at 3 months. There were significant correlations between UCH-L1 CSF and serum median concentrations (r(s) = 0.59, p < 0.001), AUC (r(s) = 0.3, p = 0.027), Tmax (r(s) = 0.68, p < 0.001), and MRT (r(s) = 0.65, p < 0.001). Outcome analysis showed significant increases in median serum AUC (2016 versus 265 ng/mL(star)min, p = 0.006), and Cmax (2 versus 0.4 ng/mL, p = 0.003), and a shorter Tmax (8 versus 19 h, p = 0.04) in those who died versus those who survived, respectively. In the first 24 h after injury, there was a statistically significant acute increase in CSF and serum median Cmax((0-24h)) in those who died. This study shows a significant correlation between UCH-L1 CSF and serum median concentrations and biokinetics in severe TBI patients, and relationships with clinical outcome were detected. C1 [Brophy, Gretchen M.] Virginia Commonwealth Univ, Richmond, VA 23298 USA. [Hayes, Ronald L.] Univ Florida, Dept Clin Programs, Banyan Biomarkers Inc, Gainesville, FL USA. [Mondello, Stefania] Univ Florida, Ctr Innovat Res, Gainesville, FL USA. [Mondello, Stefania; Robicsek, Steven A.; Gabrielli, Andrea; Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Papa, Linda] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Tepas, Joseph, III] Univ Florida, Dept Surg & Pediat, Jacksonville, FL USA. [Buki, Andras] Univ Pecs, Dept Neurosurg, Pecs, Hungary. [Robertson, Claudia] Baylor Coll Med, Dept Crit Care, Houston, TX 77030 USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Ctr Innovat Res, Banyan Biomarkers Inc, Gainesville, FL USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. RP Brophy, GM (reprint author), Virginia Commonwealth Univ, Med Coll Virginia Campus,410 N 12th St,POB 980533, Richmond, VA 23298 USA. EM gbrophy@vcu.edu RI Mondello, Stefania/A-1813-2012; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DoD W81XWH-06-1-0517]; National Institutes of Health [R01 NS052831] FX This study was supported in part by Department of Defense Award number DoD W81XWH-06-1-0517, and National Institutes of Health Award number R01 NS052831. NR 16 TC 70 Z9 73 U1 0 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP 861 EP 870 DI 10.1089/neu.2010.1564 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600002 PM 21309726 ER PT J AU Garman, RH Jenkins, LW Switzer, RC Bauman, RA Tong, LC Swauger, PV Parks, SA Ritzel, DV Dixon, E Clark, RSB Bayir, H Kagan, V Jackson, EK Kochanek, PM AF Garman, Robert H. Jenkins, Larry W. Switzer, Robert C., III Bauman, Richard A. Tong, Lawrence C. Swauger, Peter V. Parks, Steven A. Ritzel, David V. Dixon, Edward Clark, Robert S. B. Bayir, Huelya Kagan, Valerian Jackson, Edwin K. Kochanek, Patrick M. TI Blast Exposure in Rats with Body Shielding Is Characterized Primarily by Diffuse Axonal Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE hypothermia; neurotransmitters; proteomics; receptor antagonists; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; EXPLOSIVE BLAST; SILVER; NEURODEGENERATION; NEUROTRAUMA; NEURONS; MODEL AB Blast-induced traumatic brain injury (TBI) is the signature insult in combat casualty care. Survival with neurological damage from otherwise lethal blast exposures has become possible with body armor use. We characterized the neuropathologic alterations produced by a single blast exposure in rats using a helium-driven shock tube to generate a nominal exposure of 35 pounds per square inch (PSI) (positive phase duration similar to 4 msec). Using an IACUC-approved protocol, isoflurane-anesthetized rats were placed in a steel wedge (to shield the body) 7 feet inside the end of the tube. The left side faced the blast wave (with head-only exposure); the wedge apex focused a Mach stem onto the rat's head. The insult produced similar to 25% mortality (due to impact apnea). Surviving and sham rats were perfusion-fixed at 24 h, 72 h, or 2 weeks post-blast. Neuropathologic evaluations were performed utilizing hematoxylin and eosin, amino cupric silver, and a variety of immunohistochemical stains for amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba1), ED1, and rat IgG. Multifocal axonal degeneration, as evidenced by staining with amino cupric silver, was present in all blast-exposed rats at all time points. Deep cerebellar and brainstem white matter tracts were most heavily stained with amino cupric silver, with the morphologic staining patterns suggesting a process of diffuse axonal injury. Silver-stained sections revealed mild multifocal neuronal death at 24 h and 72 h. GFAP, ED1, and Iba1 staining were not prominently increased, although small numbers of reactive microglia were seen within areas of neuronal death. Increased blood-brain barrier permeability (as measured by IgG staining) was seen at 24 h and primarily affected the contralateral cortex. Axonal injury was the most prominent feature during the initial 2 weeks following blast exposure, although degeneration of other neuronal processes was also present. Strikingly, silver staining revealed otherwise undetected abnormalities, and therefore represents a recommended outcome measure in future studies of blast TBI. C1 [Garman, Robert H.; Jenkins, Larry W.; Dixon, Edward; Clark, Robert S. B.; Bayir, Huelya; Kagan, Valerian; Jackson, Edwin K.; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. [Clark, Robert S. B.; Bayir, Huelya; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA 15260 USA. [Jenkins, Larry W.; Dixon, Edward] Univ Pittsburgh, Sch Med, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Garman, Robert H.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USA. [Jackson, Edwin K.] Univ Pittsburgh, Sch Med, Dept Med Pharmacol, Pittsburgh, PA 15260 USA. [Kagan, Valerian] Univ Pittsburgh, Sch Med, Dept Environm Occupat Hlth, Pittsburgh, PA 15260 USA. [Bauman, Richard A.; Tong, Lawrence C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Swauger, Peter V.; Parks, Steven A.] ORA Inc, Fredericksburg, VA USA. [Switzer, Robert C., III] NeuroSci Associates, Knoxville, TN USA. [Ritzel, David V.] Dyn FX Consulting Ltd, Amherstburg, ON, Canada. RP Garman, RH (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, 3434 5th Ave, Pittsburgh, PA 15260 USA. EM vetpathol@cs.com RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X FU DARPA [N66001-10-C-2124] FX This work was supported by the DARPA PREVENT blast program N66001-10-C-2124. The views, opinions, and/or findings contained in this manuscript should not be interpreted as representing the official views or policies, either expressed or implied, of DARPA or the Department of Defense. Dr. Switzer has commercial interests in a company (NeuroScience Associates) that performs CNS amino cupric silver stains for academia, government, and industry. NR 27 TC 94 Z9 94 U1 0 U2 19 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP 947 EP 959 DI 10.1089/neu.2010.1540 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600009 PM 21449683 ER PT J AU Nakagawa, A Manley, GT Gean, AD Ohtani, K Armonda, R Tsukamoto, A Yamamoto, H Takayama, K Tominaga, T AF Nakagawa, Atsuhiro Manley, Geoffrey T. Gean, Alisa D. Ohtani, Kiyonobu Armonda, Rocco Tsukamoto, Akira Yamamoto, Hiroaki Takayama, Kazuyoshi Tominaga, Teiji TI Mechanisms of Primary Blast-Induced Traumatic Brain Injury: Insights from Shock-Wave Research SO JOURNAL OF NEUROTRAUMA LA English DT Review DE biomedical engineering; blast injury; traumatic brain injury ID CENTRAL-NERVOUS-SYSTEM; ADMINISTRATION RATE DEPENDENCE; CONTROLLED CORTICAL IMPACT; INDUCED RENAL INJURY; INDUCED LIQUID JET; RAT-BRAIN; IN-VITRO; OVERPRESSURE INJURY; INDUCED NEUROTRAUMA; PRESSURE WAVES AB Traumatic brain injury caused by explosive or blast events is traditionally divided into four phases: primary, secondary, tertiary, and quaternary blast injury. These phases of blast-induced traumatic brain injury (bTBI) are biomechanically distinct and can be modeled in both in vivo and in vitro systems. The primary bTBI injury phase represents the response of brain tissue to the initial blast wave. Among the four phases of bTBI, there is a remarkable paucity of information about the cause of primary bTBI. On the other hand, 30 years of research on the medical application of shockwaves (SW) has given us insight into the mechanisms of tissue and cellular damage in bTBI, including both air-mediated and underwater SW sources. From a basic physics perspective, the typical blast wave consists of a lead SW followed by supersonic flow. The resultant tissue injury includes several features observed in bTBI, such as hemorrhage, edema, pseudoaneurysm formation, vasoconstriction, and induction of apoptosis. These are well-described pathological findings within the SW literature. Acoustic impedance mismatch, penetration of tissue by shock/bubble interaction, geometry of the skull, shear stress, tensile stress, and subsequent cavitation formation, are all important factors in determining the extent of SW-induced tissue and cellular injury. Herein we describe the requirements for the adequate experimental set-up when investigating blast-induced tissue and cellular injury; review SW physics, research, and the importance of engineering validation (visualization/pressure measurement/numerical simulation); and, based upon our findings of SW-induced injury, discuss the potential underlying mechanisms of primary bTBI. C1 [Nakagawa, Atsuhiro] Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, Sendai, Miyagi 9808574, Japan. [Nakagawa, Atsuhiro; Manley, Geoffrey T.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA. [Nakagawa, Atsuhiro; Manley, Geoffrey T.; Gean, Alisa D.] Univ Calif San Francisco, Brain & Spinal Injury Ctr, San Francisco, CA USA. [Gean, Alisa D.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA. [Ohtani, Kiyonobu; Yamamoto, Hiroaki; Takayama, Kazuyoshi] Tohoku Univ, Inst Fluid Sci, Interdisciplinary Shock Wave Applicat Res Div, Tohoku, Japan. [Armonda, Rocco] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. [Tsukamoto, Akira] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Tokyo, Japan. RP Nakagawa, A (reprint author), Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan. EM nakg_neurosurg@yahoo.co.jp FU Japanese Ministry of Education, Culture, Sports, Science, and Technology [18390388, 19390372, 19689028, 21659313, 21659334]; General Insurance Association of Japan; Japanese Foundation for Research and Promotion of Endoscopy; Tohoku University FX Part of this work was carried out under the Collaborative Research Project of the Institute of Fluid Science, Tohoku University. This work was supported in part by a grant-in-aid for scientific research (B) (no. 18390388 and 19390372), a grant-in-aid for young scientists (A) (no. 19689028), and Challenging Exploratory Research (no. 21659313 and 21659334) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology, a 2010 Research Grant from The General Insurance Association of Japan, The Japanese Foundation for Research and Promotion of Endoscopy, and the Tohoku University Exploratory Research Program for Young Scientists (ERYs). We also thank Shokichi Hayasaka and Toshihiro Ogawa (Institute of Fluid Science, Tohoku University) for technical support. We thank Lawrence Pitts, M. D., Richard Bauman, Ph.D., Harris Odette, M. D., MPH., Graham Creasey, M. D., FRCSEd., Guy Rosenthal, M. D., Ph.D., Greg Clement, Ph.D., Mark Richardson, M. D., Ph.D., Vincent Wang, M. D., Ph.D., and Lai Yee Leung, Ph.D., for discussion. NR 186 TC 68 Z9 72 U1 2 U2 47 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP 1101 EP 1119 DI 10.1089/neu.2010.1442 PG 19 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600021 PM 21332411 ER PT J AU Gyorgy, A Ling, G Wingo, D Walker, J Tong, L Parks, S Januszkiewicz, A Baumann, R Agoston, DV AF Gyorgy, Andrea Ling, Geoffrey Wingo, Daniel Walker, John Tong, Lawrence Parks, Steve Januszkiewicz, Adolph Baumann, Richard Agoston, Denes V. TI Time-Dependent Changes in Serum Biomarker Levels after Blast Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarkers; blast traumatic brain injury; reverse phase protein microarray ID NEURON-SPECIFIC ENOLASE; HEAD-INJURY; CARDIAC-ARREST; SPONTANEOUS CIRCULATION; BIOCHEMICAL MARKERS; NEUROFILAMENT; PROTEIN; S-100B; DAMAGE; PREDICTORS AB Neuronal and glial proteins detected in the peripheral circulating blood after injury can reflect the extent of the damage caused by blast traumatic brain injury (bTBI). The temporal pattern of their serum levels can further predict the severity and outcome of the injury. As part of characterizing a large-animal model of bTBI, we determined the changes in the serum levels of S100B, neuron-specific enolase (NSE), myelin basic protein (MBP), and neurofilament heavy chain (NF-H). Blood samples were obtained prior to injury and at 6, 24, 72 h, and 2 weeks post-injury from animals with different severities of bTBI; protein levels were determined using reverse phase protein microarray (RPPM) technology. Serum levels of S100B, MBP, and NF-H, but not NSE, showed a time-dependent increase following injury. The detected changes in S100B and MBP levels showed no correlation with the severity of the injury. However, serum NF-H levels increased in a unique, rapid manner, peaking at 6 h post-injury only in animals exposed to severe blast with poor clinical and pathological outcomes. We conclude that the sudden increase in serum NF-H levels following bTBI may be a useful indicator of injury severity. If additional studies verify our findings, the observed early peak of serum NF-H levels can be developed into a useful diagnostic tool for predicting the extent of damage following bTBI. C1 [Agoston, Denes V.] Uniformed Serv Univ USU, Dept Anat Physiol & Genet, Program Neurosci, Natl Capital Consortium,Neurosurg Program,Sch Med, Bethesda, MD 20814 USA. [Ling, Geoffrey] Uniformed Serv Univ USU, Dept Neurol, Bethesda, MD USA. [Tong, Lawrence; Januszkiewicz, Adolph; Baumann, Richard] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD USA. [Parks, Steve] ORA Inc, Fredericksburg, VA USA. RP Agoston, DV (reprint author), Uniformed Serv Univ USU, Dept Anat Physiol & Genet, Program Neurosci, Natl Capital Consortium,Neurosurg Program,Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM vagoston@usuhs.mil FU DARPA PREVENT FX The work was funded by DARPA PREVENT. We thank Mrs. Carla Olsen for her help with the statistical analysis, and Ms. Nicole Draghic and Ms. Alaa Kamnaksh for editorial support. NR 36 TC 34 Z9 37 U1 0 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP 1121 EP 1126 DI 10.1089/neu.2010.1561 PG 6 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600022 PM 21428721 ER PT J AU Arun, P Biggemann, L Long, J Nambiar, M AF Arun, Peethambaran Biggemann, Lionel Long, Joseph Nambiar, Madhusoodana TI STUDIES ON BLAST-INDUCED TRAUMATIC BRAIN INJURY USING AN IN VITRO MODEL SYSTEM WITH SHOCK TUBE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Arun, Peethambaran; Biggemann, Lionel; Long, Joseph; Nambiar, Madhusoodana] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A20 EP A20 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600075 ER PT J AU Brophy, G Mondello, S Papa, L Robicsek, S Gabrielli, A Tepas, J Buki, A Schmid, K Robertson, C Tortella, F Hayes, R Wang, K AF Brophy, Gretchen Mondello, Stefania Papa, Linda Robicsek, Steve Gabrielli, Andrea Tepas, Joseph, III Buki, Andras Schmid, Kara Robertson, Claudia Tortella, Frank Hayes, Ron Wang, Kevin TI QUANTITATIVE CEREBROSPINAL FLUID BIOKINETIC PARAMETERS OF ALPHA II-SPECTRIN BREAKDOWN PRODUCTS IN SEVERE TRAUMATIC BRAIN INJURY PATIENTS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Brophy, Gretchen] Virginia Commonwealth Univ, Richmond, VA USA. [Mondello, Stefania; Robicsek, Steve; Gabrielli, Andrea] Univ Florida, Gainesville, FL USA. [Papa, Linda] Orlando Reg Med Ctr Inc, Orlanado, FL USA. [Tepas, Joseph, III] Univ Florida, Jacksonville, FL USA. [Buki, Andras] Univ Pecs, Pecs, Hungary. [Robertson, Claudia] Baylor Coll Med, Houston, TX 77030 USA. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Hayes, Ron; Wang, Kevin] Banyan Biomarkers Inc, Alachua, FL USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A114 EP A114 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600355 ER PT J AU Chen, ZY Liao, ZL Leung, LY Mountney, A Yao, CP Yang, WH Lu, XCM Dave, J Wei, G Deng-Bryant, Y Schmid, K Shear, D Tortella, F AF Chen, Zhiyong Liao, Zhilin Leung, LaiYee Mountney, Andrea Yao, Changping Yang, Weihong Lu, Xi-Chun May Dave, Jitendra Wei, Guo Deng-Bryant, Ying Schmid, Kara Shear, Deborah Tortella, Frank TI THE WRAIR MODEL OF PROJECTILE CONCUSSIVE IMPACT (PCI) INJURY: II. IN VIVO MODELING ACROS INJURY SEVERITIES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Chen, Zhiyong; Liao, Zhilin; Leung, LaiYee; Mountney, Andrea; Yao, Changping; Yang, Weihong; Lu, Xi-Chun May; Dave, Jitendra; Wei, Guo; Deng-Bryant, Ying; Schmid, Kara; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A117 EP A118 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600365 ER PT J AU Cope, E Morris, D Vanlandingham, J Scrimgeour, A Levenson, C AF Cope, Elise Morris, Deborah Vanlandingham, Jacob Scrimgeour, Angus Levenson, Cathy TI ZINC SUPPLEMENTATION IMPROVES RESLIENCY TO TBI BY REDUCING DEPRESSION AND ENHANCING SPATIAL LEARNING AND MEMORY IN A RAT MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Cope, Elise; Morris, Deborah; Vanlandingham, Jacob; Levenson, Cathy] Florida Statue Univ, Tallahassee, FL USA. [Scrimgeour, Angus] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A49 EP A49 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600161 ER PT J AU Cunningham, TL Shear, DA Lu, XCM Mountney, A Long, M van der Merwe, C Tortella, F AF Cunningham, Tracy L. Shear, Deborah A. Lu, Xi-Chun May Mountney, Andrea Long, Melissa van der Merwe, Christopher Tortella, Frank TI THE TEMPORAL GRADIENT PROFILE OF BLOOD-BRAIN BARRIER DISRUPTION FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY USING LARGE AND SMALL MOLECULE TRACERS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Cunningham, Tracy L.; Shear, Deborah A.; Lu, Xi-Chun May; Mountney, Andrea; Long, Melissa; van der Merwe, Christopher; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A117 EP A117 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600363 ER PT J AU Dave, J Yao, CP Ahlers, S Stone, J Shaughness, M Hall, A McCarron, R Schmid, K Tortella, F AF Dave, Jitendra Yao, Changping Ahlers, Stephen Stone, James Shaughness, Michael Hall, Aaron McCarron, Richard Schmid, Kara Tortella, Frank TI SERUM GFAP: A POTENTIAL BIOMARKER OF MILD TRAUMATIC BRAIN INJURY PRODUCED BY REPEATED EXPOSURE TO LOW LEVEL BLAST OVERPRESSURE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Dave, Jitendra; Yao, Changping; Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ahlers, Stephen; Shaughness, Michael; Hall, Aaron; McCarron, Richard] Naval Med Res Ctr, Silver Spring, MD USA. [Stone, James] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A118 EP A119 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600369 ER PT J AU Dave, JR Yao, CP Cartagena, CM Shear, DA Chen, ZY Schmid, KE Caggiano, AO Iaci, JF Tortella, FC AF Dave, Jitendra R. Yao, Changping Cartagena, Casandra M. Shear, Deborah A. Chen, Zhiyong Schmid, Kara E. Caggiano, Anthony O. Iaci, Jennifer F. Tortella, Frank C. TI ACUTE NEUROPROTECTIVE EFFECTS OF GLIAL GROWTH FACTOR 2 ON PROTEIN CHANGES FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Dave, Jitendra R.; Yao, Changping; Cartagena, Casandra M.; Shear, Deborah A.; Chen, Zhiyong; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Caggiano, Anthony O.; Iaci, Jennifer F.] Acorda Therapeut Inc, Hawthorne, NY USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A120 EP A121 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600375 ER PT J AU Khatri, V Shear, DA Pedersen, RC Sun, JA Long, M Lu, XCM Tortella, FC AF Khatri, Vivek Shear, Deborah A. Pedersen, Rebecca C. Sun, Justin A. Long, Melissa Lu, Xi-Chun May Tortella, Frank C. TI PROGESTERONE DOSE-RESPONSE PROFILE AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RODENTS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Khatri, Vivek; Shear, Deborah A.; Pedersen, Rebecca C.; Sun, Justin A.; Long, Melissa; Lu, Xi-Chun May; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A119 EP A119 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600370 ER PT J AU Leung, LY Chen, ZY Liao, ZL Lu, XCM Dave, J Wei, G Yang, WH Schmid, K Shear, D Tortella, F AF Leung, Lai Yee Chen, Zhiyong Liao, Zhilin Lu, Xi-Chun May Dave, Jitendra Wei, Guo Yang, Weihong Schmid, Kara Shear, Deborah Tortella, Frank TI THE WRAIR MODEL OF PROJECTILE CONCUSSIVE IMPACT (PCI): I. DEVICE DEVELOPMENT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Leung, Lai Yee; Chen, Zhiyong; Liao, Zhilin; Lu, Xi-Chun May; Dave, Jitendra; Wei, Guo; Yang, Weihong; Schmid, Kara; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600366 ER PT J AU Leung, LY Wei, G Khatri, V Shear, D Tortella, F AF Leung, Lai Yee Wei, Guo Khatri, Vivek Shear, Deborah Tortella, Frank TI DEVELOPMENT OF A MILITARY-RELEVANT POLYTRAUMA MODEL: COMBINED EFFECTS OF PENETRATING BALLISTIC-LIKE BRAIN INJURY AND HEMORRHAGIC HYPOTENSION IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Leung, Lai Yee; Wei, Guo; Khatri, Vivek; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A119 EP A119 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600371 ER PT J AU Lu, M Chen, ZY Wei, G Cao, Y Leung, L Cunningham, T Khatri, V Mountney, A Shear, D Tortella, F AF Lu, May Chen, Zhiyong Wei, Guo Cao, Ying Leung, Laiyee Cunningham, Tracy Khatri, Vivek Mountney, Andrea Shear, Deborah Tortella, Frank TI DOSE RESPONSE EFFECTS OF PHENYTOIN ON ATTENUATION OF NONCONVULSIVE SEIZURES CAUSED BY PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Lu, May; Chen, Zhiyong; Wei, Guo; Cao, Ying; Leung, Laiyee; Cunningham, Tracy; Khatri, Vivek; Mountney, Andrea; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A121 EP A121 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600376 ER PT J AU Mondello, S Gabrielli, A Catani, S D'Ippolito, M Schmid, K Tortella, F Wang, KV Hayes, R Formisano, R AF Mondello, Stefania Gabrielli, Andrea Catani, Sheila D'Ippolito, Mariagrazia Schmid, Kara Tortella, Frank Wang, Kevin Hayes, Ronald Formisano, Rita TI MAP-2 CONCENTRATION IN SERUM OF PATIENTS AFTER TRAUMATIC BRAIN INJURY: INSIGHT INTO THE PATHOPHYSIOLOGICAL MECHANISMS OF THE CHRONIC PHASE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Mondello, Stefania; Gabrielli, Andrea] Univ Florida, Gainesville, FL USA. [Wang, Kevin; Hayes, Ronald] Banyan Biomarkers Inc, Alachua, FL USA. [Catani, Sheila; D'Ippolito, Mariagrazia; Formisano, Rita] Santa Lucia Fdn, Rome, Italy. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A83 EP A84 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600264 ER PT J AU Mondello, S Jeromin, A Bullock, R Sweaney, JXM Streeter, J Schmid, K Tortella, F Hayes, R Wang, KV AF Mondello, Stefania Jeromin, Andreas Bullock, Ross Sweaney, Jixiang Mo Streeter, Jackson Schmid, Kara Tortella, Frank Hayes, Ronald Wang, Kevin TI IN VIVO MONITORING OF CYTOKINES AND BRAIN BIOMARKER DAMAGE FOLLOWING SEVERE TRAUMATIC BRAIN INJURY: A MICRODIALYSIS STUDY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Mondello, Stefania] Univ Florida, Gainesville, FL USA. [Jeromin, Andreas; Sweaney, Jixiang Mo; Streeter, Jackson; Hayes, Ronald; Wang, Kevin] Banyan Biomarkers Inc, Alachua, FL USA. [Bullock, Ross] Univ Miami, Miami, FL USA. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A84 EP A84 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600265 ER PT J AU Mountney, A Leung, LY Chen, ZY Lu, XCM Liao, ZL Yang, WH Schmid, KE Shear, DA Tortella, FC AF Mountney, Andrea Leung, Lai Yee Chen, Zhiyong Lu, Xi-Chun May Liao, Zhilin Yang, Weihong Schmid, Kara E. Shear, Deborah A. Tortella, Frank C. TI THE WRAIR MODEL OF PROJECTILE CONCUSSIVE IMPACT (PCI): III. ACUTE BEHAVIORAL ANALYSIS IN A MILD BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Mountney, Andrea; Leung, Lai Yee; Chen, Zhiyong; Lu, Xi-Chun May; Liao, Zhilin; Yang, Weihong; Schmid, Kara E.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600367 ER PT J AU Papa, L Demery, J Dixit, N Braga, C Zhang, ZQ Brophy, G Burks, S Ilic, S Streeter, J Tortella, F Hayes, R Wang, KKW AF Papa, Linda Demery, Jason Dixit, Neha Braga, Carolina Zhang, Zhiqun Brophy, Gretchen Burks, Stephen Ilic, Sanja Streeter, Jackson Tortella, Frank Hayes, Ronald Wang, Kevin K. W. TI EARLY SERUM LEVELS OF GLIAL FIBRILLARY ACIDIC PROTEIN BREAKDOWN PRODUCT (GFAP-BDP) ARE ASSOCITED WITH GLOBAL OUTCOME AT ONE MONTH POST INJURY IN MILD AND MODERATE TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Papa, Linda; Braga, Carolina; Wang, Kevin K. W.] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Demery, Jason] Univ Florida, Gainesville, FL USA. [Dixit, Neha] NF SG Vet Hlth Syst, Gainesville, FL USA. [Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Zhang, Zhiqun; Ilic, Sanja; Streeter, Jackson; Hayes, Ronald] Banyan Biomarkers Inc, Alachua, FL USA. [Brophy, Gretchen] Virginia Commonwealth Univ, Richmond, VA USA. [Burks, Stephen] Univ Miami, Miami, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A63 EP A64 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600204 ER PT J AU Papa, L Lewis, L Falk, J Demery, J Brophy, G Liu, MC Mo, JX Mondello, S Schmid, K Robertson, C Tortella, F Hayes, R Wang, KKW AF Papa, Linda Lewis, Lawrence Falk, Jay Demery, Jason Brophy, Gretchen Liu, Ming-Cheng Mo, Jixiang Mondello, Stefania Schmid, Kara Robertson, Claudia Tortella, Frank Hayes, Ronald Wang, Kevin K. W. TI SERUM LEVELS OF UCH-L1 DISTINGUISHES MILD AND MODERATE TRAUMATIC BRAIN INJURY FROM TRAUMA CONTROLS AND IS ASSOCIATED WITH LESIONS ON COMPUTED TOMOGRAPHY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Papa, Linda; Falk, Jay] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Lewis, Lawrence] Washington Univ, St Louis, MO USA. [Liu, Ming-Cheng; Mo, Jixiang; Mondello, Stefania; Hayes, Ronald; Wang, Kevin K. W.] Banyan Biomarkers Inc, Alachua, FL USA. [Brophy, Gretchen] Virginia Commonwealth Univ, Richmond, VA USA. [Demery, Jason] Univ Florida, Gainesville, FL USA. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Robertson, Claudia] Baylor Coll Med, Houston, TX 77030 USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A5 EP A5 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600034 ER PT J AU Prima, V Glushakova, O Svetlov, A Sherman, A Kirk, D Gutierrez, H Curley, K Hayes, R Wang, K Svetlov, S AF Prima, Victor Glushakova, Olena Svetlov, Archie Sherman, Alexandra Kirk, Daniel Gutierrez, Hector Curley, Kenneth Hayes, Ronald Wang, Kevin Svetlov, Stanislav TI RESPONSES TO PRIMARY VS. "COMPOSITE" BLAST OVERPRESSURE IN THE MIRROR OF PROTEIN BIOMARKERS IN RAT MODELS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Prima, Victor; Glushakova, Olena; Svetlov, Archie; Sherman, Alexandra; Hayes, Ronald; Wang, Kevin; Svetlov, Stanislav] Banyan Biomarkers, Ctr Innovat Res, Alachua, FL USA. [Kirk, Daniel; Gutierrez, Hector] Florida Inst Technol, Melbourne, FL 32901 USA. [Curley, Kenneth] USA, Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A38 EP A39 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600130 ER PT J AU Shaughness, M Maudlin-Jeronimo, E Hall, A Shear, D McCarron, R Stone, J Ahlers, S AF Shaughness, Michael Maudlin-Jeronimo, Eric Hall, Aaron Shear, Deborah McCarron, Richard Stone, James Ahlers, Stephen TI EVALUATION OF CORTICOSTERONE AFTER REPEATED EXPOSURE TO LOW LEVEL BLAST OVERPRESSURE IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Shaughness, Michael; Maudlin-Jeronimo, Eric; Hall, Aaron; McCarron, Richard; Ahlers, Stephen] USN, Med Res Ctr, Silver Spring, MD USA. [Shear, Deborah] Walter Reed Army Inst Res, Silver Spring, MD USA. [Stone, James] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A61 EP A62 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600199 ER PT J AU Shear, DA Mountney, A Pedersen, R Rosen, E Sun, J Long, M Lu, XCM Tortella, FC AF Shear, Deborah A. Mountney, Andrea Pedersen, Rebecca Rosen, Elliot Sun, Justin Long, Melissa Lu, X. C. May Tortella, Frank C. TI NEUROPROTECTIVE DOSE-RESPONSE PROFILE OF DEXTROMETHORPHAN IN A RODENT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Shear, Deborah A.; Mountney, Andrea; Pedersen, Rebecca; Rosen, Elliot; Sun, Justin; Long, Melissa; Lu, X. C. May; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A120 EP A120 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600374 ER PT J AU Shear, DA Chen, ZY Schmid, KE Caggiano, AO Iaci, JF Tortella, FC Dave, JR AF Shear, Deborah A. Chen, Zhiyong Schmid, Kara E. Caggiano, Anthony O. Iaci, Jennifer F. Tortella, Frank C. Dave, Jitendra R. TI ACUTE NEUROPROTECTIVE EFFECTS OF GLIAL GROWTH FACTOR 2 IN A MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Shear, Deborah A.; Chen, Zhiyong; Schmid, Kara E.; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. [Caggiano, Anthony O.; Iaci, Jennifer F.] ACORDA Therapeut Inc, Hawthorne, NY USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A120 EP A120 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600373 ER PT J AU Wang, Y Wei, YL Oguntayo, S Arun, P Biggemann, L Valiyaveettil, M Song, J Nambiar, M AF Wang, Ying Wei, Yanling Oguntayo, Samuel Arun, Peethambaran Biggemann, Lionel Valiyaveettil, Manojkumar Song, Jian Nambiar, Madhusoodana TI REPEATED BLAST-INDUCED NEUROBIOLOGICAL EFFECTS IN MICE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Arun, Peethambaran; Biggemann, Lionel; Valiyaveettil, Manojkumar; Song, Jian; Nambiar, Madhusoodana] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A117 EP A117 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600364 ER PT J AU Wei, G Yang, XF Lu, XCM Shear, DA Tortella, FC AF Wei, Guo Yang, Xiaofang Lu, Xi-Chun M. Shear, Deborah A. Tortella, Frank C. TI SELECTIVE BRAIN COOLING ATTENUATES THE AXONAL DAMAGE FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Wei, Guo; Yang, Xiaofang; Lu, Xi-Chun M.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600368 ER PT J AU Zoltewicz, S Yang, BX Yang, CP Lu, XCM Dave, JR Shear, DA Schmid, K Tortella, FC Hayes, RL Zhang, ZQ Wang, KKW AF Zoltewicz, Susie Yang, Boxuan Yang, Changping Lu, Xi-Chun May Dave, Jitendra R. Shear, Deborah A. Schmid, Kara Tortella, Frank C. Hayes, Ronald L. Zhang, Zhiqun Wang, Kevin K. W. TI BIOMARKERS TRACK INJURY SEVERITY IN A RAT MODEL OF PENETRATING BALLISTIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Zoltewicz, Susie; Yang, Boxuan; Hayes, Ronald L.; Zhang, Zhiqun; Wang, Kevin K. W.] Banyan Biomarkers Inc, Alachua, FL USA. [Yang, Changping; Lu, Xi-Chun May; Dave, Jitendra R.; Shear, Deborah A.; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A39 EP A39 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600131 ER PT J AU Stepanov, V Anglade, V Hummers, WAB Bezmelnitsyn, AV Krasnoperov, LN AF Stepanov, Victor Anglade, Venant Hummers, Wendy A. Balas Bezmelnitsyn, Andrey V. Krasnoperov, Lev N. TI Production and Sensitivity Evaluation of Nanocrystalline RDX-based Explosive Compositions SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Initiation; Nanocrystalline; RDX; RESS; Sensitivity ID IMPACT AB The initiation sensitivity of cyclotrimethylenetrinitramine (RDX) was investigated as a function of crystal size. For this study, RDX powders with mean crystal sizes of ca. 200 and 500 nm were prepared by rapid expansion of supercritical solutions (RESS) with carbon dioxide as the solvent. Initiation sensitivity testing to impact, sustained shock, and electrostatic discharge stimuli was performed on uncoated as well as wax-coated specimens. The test data revealed that in a direct comparison to coarser grades the nanocrystalline RDX-based samples were substantially less sensitive to shock and impact stimuli. Furthermore, the 500 nm RDX-based specimens exhibited the lowest sensitivity values, an indication that minima in shock and impact sensitivities with respect to crystal size exist. C1 [Stepanov, Victor; Anglade, Venant; Hummers, Wendy A. Balas] USA, RDECOM ARDEC, Munit Engn Technol Ctr Picatinny, Arsenal, NJ 07806 USA. [Bezmelnitsyn, Andrey V.; Krasnoperov, Lev N.] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA. RP Stepanov, V (reprint author), USA, RDECOM ARDEC, Munit Engn Technol Ctr Picatinny, Arsenal, NJ 07806 USA. EM victor.stepanov@us.army.mil FU US Army ARDEC [DAAE30-02-C-1140] FX This work was supported by US Army ARDEC under contract DAAE30-02-C-1140. The authors are grateful to Theodore J. Dolch, Amy D. Wilson, and Aleksander Gandzelko for their assistance with sample characterization and also to Steven M. Nicolich and Michael Miller for valuable discussions. NR 22 TC 26 Z9 27 U1 0 U2 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2011 VL 36 IS 3 BP 240 EP 246 DI 10.1002/prep.201000114 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 787WO UT WOS:000292407600006 ER PT J AU Arora, R Kaplan, M Nelson, M AF Arora, Rajiv Kaplan, Michael Nelson, Michael TI ENTEROVIRUS-SPECIFIC IGG IN INTRAVENOUS IMMUNOGLOBULIN PREPARATIONS SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter ID INFECTIONS; ANTIBODIES; GLOBULIN C1 [Arora, Rajiv] William Beaumont Army Med Ctr, Allergy Immunol Clin, El Paso, TX 79920 USA. [Kaplan, Michael] Natl Naval Med Ctr, Bethesda, MD USA. [Nelson, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Arora, R (reprint author), William Beaumont Army Med Ctr, Allergy Immunol Clin, El Paso, TX 79920 USA. EM rajiv.arora@its.army.mil NR 8 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD JUN PY 2011 VL 106 IS 6 BP 544 EP 545 DI 10.1016/j.anai.2011.03.007 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 779IB UT WOS:000291770200020 PM 21624761 ER PT J AU Mei, YH Lu, GQ Chen, X Luo, SF Ibitayo, D AF Mei, Yunhui Lu, Guo-Quan Chen, Xu Luo, Shufang Ibitayo, Dimeji TI Effect of Oxygen Partial Pressure on Silver Migration of Low-Temperature Sintered Nanosilver Die-Attach Material SO IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY LA English DT Article DE High-temperature electronic packaging; low-temperature joining technique (LTJT); nanosilver die attach; oxygen partial pressure; silver migration ID RELIABILITY; CONDUCTORS; FILMS; PASTE AB The low-temperature joining technique of silver sintering is being actively pursued in the power electronics industry as a lead-free die-attach solution for packaging power devices and modules. However, one of the concerns of this technique is the migration of silver at a high temperature. Recently, we have reported our findings of the migration of a low-temperature sintered nanosilver in dry air at a temperature over 250 degrees C. In this paper, we report our results of the effect of oxygen partial pressure on the migration kinetics of the sintered nanosilver at 400 degrees C under an electrical field strength of 50 V/mm. The range of the oxygen partial pressure tested was between < 0.01 and 0.40 atm. The silver migration kinetics were monitored by measuring the leakage current across a metal-finger pattern, which allowed the determination of the "lifetime," or the onset time for significant leakage current developed across the two electrodes. With decreasing oxygen partial pressure, the lifetime increases exponentially. Our results suggest that the concern for silver migration in a high-temperature application of sintered silver die attach can be effectively remedied through packaging to keep oxygen away from the silver joints. C1 [Mei, Yunhui; Lu, Guo-Quan] Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. [Mei, Yunhui; Chen, Xu] Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R China. [Lu, Guo-Quan] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. [Luo, Shufang] NBE Technol LLC, Blacksburg, VA 24060 USA. [Ibitayo, Dimeji] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Mei, YH (reprint author), Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. EM yunhui08@vt.edu; gqlu@vt.edu; xchen@tju.edu.cn; sluo@nbetech.com; DIbitayo@arl.army.mil RI Chen, Xu/A-8487-2008; Lu, Guo-Quan/N-3661-2013; Mei, Yunhui/N-1095-2013 OI Mei, Yunhui/0000-0002-6508-4343 FU U.S. Army Research Laboratory [W911NF-07-R-0001]; National Natural Science Foundation of China [50528506] FX This work was supported in part by the U.S. Army Research Laboratory under Contract W911NF-07-R-0001 and in part by the National Natural Science Foundation of China under Grant 50528506. NR 17 TC 22 Z9 22 U1 2 U2 32 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-4388 J9 IEEE T DEVICE MAT RE JI IEEE Trans. Device Mater. Reliab. PD JUN PY 2011 VL 11 IS 2 BP 312 EP 315 DI 10.1109/TDMR.2010.2056372 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 779ZE UT WOS:000291819900014 ER PT J AU Mei, YH Lu, GQ Chen, X Luo, SF Ibitayo, D AF Mei, Yunhui Lu, Guo-Quan Chen, Xu Luo, Shufang Ibitayo, Dimeji TI Migration of Sintered Nanosilver Die-Attach Material on Alumina Substrate Between 250 degrees C and 400 degrees C in Dry Air SO IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY LA English DT Article DE High-temperature packaging; low-temperature sintering of nanosilver paste; silver migration; sintered die attach ID SILVER MIGRATION; AG; ELECTROMIGRATION; CONDUCTORS; DEVICES; FILMS; PASTE AB The low-temperature joining of semiconductor chips by sintering of silver paste is emerging as an alternative lead-free solution for power electronics devices and modules working in a high-temperature environment. A promising die-attachment material that would enable the rapid implementation of the sintering process is nanoscale silver paste, which can be sintered at temperatures below 300 degrees C without an external pressure. In this paper, we report our findings on the silver migration in sintered nanosilver electrode-pair patterns on an alumina substrate. The electrode pairs were biased at an electric field ranging from 10 to 100 V/mm and at a temperature between 250 degrees C and 400 degrees C in dry air. The leakage currents across the electrodes were measured as the silver patterns were tested in an oven. Silver dendrites formed across the electrode gap were observed under an optical microscope and analyzed using scanning electron microscopy and energy dispersive spectroscopy (EDS). The silver migration was found in the samples tested at 400 degrees C, 350 degrees C, 300 degrees C, and 250 degrees C. The measurements on the leakage current versus time were characterized by an initial incubation period, called "lifetime," followed by a sharp rise as the silver dendrites were shorting the electrodes. A simple phenomenological model was derived to account for the observed dependence of lifetime on the electric field and temperature. The EDS mappings revealed the significant presence of oxygen on the positive electrode but the complete absence on the negative electrode. A mechanism involving the oxidation of silver and the dissociation of silver oxide at the anode was suggested. We suggest that the migration of a sintered nanosilver die attachment can be prevented in high-temperature applications through packaging or encapsulation to reduce the partial pressure of oxygen. C1 [Mei, Yunhui; Chen, Xu] Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R China. [Mei, Yunhui; Lu, Guo-Quan] Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. [Lu, Guo-Quan] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. [Luo, Shufang] NBE Technol LLC, Blacksburg, VA 24061 USA. [Ibitayo, Dimeji] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Mei, YH (reprint author), Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R China. EM gqlu@vt.edu RI Chen, Xu/A-8487-2008; Lu, Guo-Quan/N-3661-2013; Mei, Yunhui/N-1095-2013 OI Mei, Yunhui/0000-0002-6508-4343 FU U.S. Army Research Laboratory [W911NF-07-R-0001]; Chinese National Science Foundation [50528506] FX This work was supported in part by the U.S. Army Research Laboratory under Contract W911NF-07-R-0001 and in part by the Chinese National Science Foundation under Grant 50528506. NR 28 TC 29 Z9 29 U1 5 U2 42 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-4388 J9 IEEE T DEVICE MAT RE JI IEEE Trans. Device Mater. Reliab. PD JUN PY 2011 VL 11 IS 2 BP 316 EP 322 DI 10.1109/TDMR.2010.2064775 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 779ZE UT WOS:000291819900015 ER PT J AU Lin, JL Sproul, WD Moore, JJ Wu, ZL Lee, S Chistyakov, R Abraham, B AF Lin, Jianliang Sproul, William D. Moore, John J. Wu, Zhili Lee, Sabrina Chistyakov, Roman Abraham, Bassam TI Recent advances in modulated pulsed power magnetron sputtering for surface engineering SO JOM LA English DT Article ID PHYSICAL VAPOR-DEPOSITION; UNBALANCED MAGNETRON; MECHANICAL-PROPERTIES; FILM PROPERTIES; HARD COATINGS; ION ENERGY; GROWTH; MICROSTRUCTURE; PLASMA; TIN AB Over the past 10 years, the development of high-power pulsed magnetron sputtering (HPPMS) has shown considerable potential in improving the quality of sputtered films by generating a high degree of ionization of the sputtered species to achieve high plasma density by using pulsed, high peak target power for a short period of time. However, the early HPPMS technique showed a significantly decreased deposition rate as compared to traditional magnetron sputtering. Recently, an alternative HPPMS deposition technique known as modulated pulsed power (MPP) magnetron sputtering has been developed. This new sputtering technique is capable of producing a high ionization fraction of sputter target species and while at the same time achieving a high deposition rate. This paper is aimed at giving a review of recent advances in the MPP technique in terms of the plasma properties, the improvements in the structure and properties of the thin films, and the important advances in the high rate deposition of high quality thick coatings on the order of 20-100 mu m in thickness. C1 [Lin, Jianliang; Sproul, William D.; Moore, John J.; Wu, Zhili] Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA. [Sproul, William D.] React Sputtering Inc, San Marcos, CA 92078 USA. [Wu, Zhili] Dalian Univ Technol, Sch Mat Sci & Engn, Surface Engn Lab, Dalian 116024, Peoples R China. [Lee, Sabrina] USA, Benet Labs, Watervliet Arsenal, NY 12189 USA. [Chistyakov, Roman] Zond Inc, Mansfield, MA USA. [Abraham, Bassam] Zpulser LLC, Mansfield, MA 02048 USA. RP Lin, JL (reprint author), Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA. EM jlin@mines.edu RI Lin, Jianliang/F-8405-2012 FU US Army; North American Die Casting Association (NADCA) FX Part of the research work supported by the US Army and the North American Die Casting Association (NADCA) is gratefully acknowledged. We are grateful for the valuable discussions from Dr. John A. Rees, Dr. David N. Ruzic, and Dr. Malki Pinkas. We are also grateful for the help from Dr. Michael J. Kaufman, Mr. Gary Zito, and Dr. John P. Chandler at the Electron Microscopy Laboratory of the Department of Metallurgical and Materials Engineering at the Colorado School of Mines. NR 64 TC 28 Z9 29 U1 1 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD JUN PY 2011 VL 63 IS 6 BP 48 EP 58 DI 10.1007/s11837-011-0092-4 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 777JD UT WOS:000291610800010 ER PT J AU Bower, KS Trudo, EW Ryan, DS Sia, RK Mines, MJ Stutzman, RD Wroblewski, KJ AF Bower, Kraig S. Trudo, Edward W. Ryan, Denise S. Sia, Rose K. Mines, Michael J. Stutzman, Richard D. Wroblewski, Keith J. TI Photorefractive keratectomy in posterior polymorphous dystrophy with vesicular and band subtypes SO JOURNAL OF CATARACT AND REFRACTIVE SURGERY LA English DT Article ID IRIDOCORNEAL ENDOTHELIAL SYNDROME; VIVO CONFOCAL MICROSCOPY; IN-SITU KERATOMILEUSIS; CORNEAL ENDOTHELIUM; SPECULAR MICROSCOPY; MYOPIA; CELL; THICKNESS; FEATURES AB PURPOSE: To evaluate the safety and efficacy of photorefractive keratectomy (PRK) in patients with posterior polymorphous dystrophy (PPMD) with vesicular and band subtypes. SETTING: Walter Reed Center for Refractive Surgery, Washington, DC, USA. DESIGN: Case series. METHODS: The records of patients with PPMD who had PRK between January 2002 and May 2009 were reviewed. Data for analysis included sex, age, ablation depth, residual stromal bed thickness, manifest spherical equivalent, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, central corneal thickness (CCT), endothelial cell density (ECD), intraocular pressure (IOP), and complications. Preoperative and postoperative results were compared using the Wilcoxon signed-rank test, with P<.05 considered significant. RESULTS: Fourteen eyes of 7 men (mean age 29.1 years +/- 9.1 [SD]; range 21 to 42 years) with at least a 6-month follow-up were reviewed. At the final follow-up (mean 19.5 months; range 6.3 to 58.3 months), all eyes had a UDVA of 20/15 and all eyes were within +/- 0.50 diopter of emmetropia. The CDVA was unchanged from preoperatively in 71.4% of eyes and improved by 1 line in 28.6%. There were no significant complications. The IOP did not change significantly over the follow-up (P=.272). At the final visit, the mean ECD (2795.3 +/- 366.0 cells/mm(2)) was unchanged from baseline (2809.1 +/- 338.3 cells/mm(2)) (P=.114). CONCLUSIONS: Photorefractive keratectomy in PPMD patients with vesicular and band subtypes resulted in excellent visual outcomes and a low incidence of adverse effects. Endothelial cell densities did not change significantly in the early postoperative period. C1 [Bower, Kraig S.; Ryan, Denise S.; Sia, Rose K.; Mines, Michael J.; Stutzman, Richard D.; Wroblewski, Keith J.] Walter Reed Army Med Ctr, Ctr Refract Surg, Washington, DC 20307 USA. [Trudo, Edward W.] Keller Army Community Hosp, West Point, NY USA. RP Bower, KS (reprint author), Wilmer Eye Inst, Green Spring Stn, Pavil 2,Suite 455, Baltimore, MD 21093 USA. EM kbower5@jhmi.edu NR 35 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0886-3350 J9 J CATARACT REFR SURG JI J. Cataract. Refract. Surg. PD JUN PY 2011 VL 37 IS 6 BP 1101 EP 1108 DI 10.1016/j.jcrs.2010.12.045 PG 8 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 778OV UT WOS:000291714900018 PM 21596253 ER PT J AU Mansfield, AJ Engel, CC AF Mansfield, Alyssa J. Engel, Charles C. TI Understanding Substance Use in Military Spouses SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Editorial Material ID ALCOHOL-USE; DEPLOYMENT; ARMY C1 [Mansfield, Alyssa J.] Natl Ctr PTSD, Pacific Isl Div, Dept Vet Affairs, Honolulu, HI 96819 USA. [Engel, Charles C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. RP Mansfield, AJ (reprint author), Natl Ctr PTSD, Pacific Isl Div, Dept Vet Affairs, 3375 Koapaka St,Suite I-560, Honolulu, HI 96819 USA. EM alyssa.mansfield@va.gov NR 9 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD JUN PY 2011 VL 18 IS 2 BP 198 EP 199 DI 10.1007/s10880-011-9244-5 PG 2 WC Psychology, Clinical SC Psychology GA 775SQ UT WOS:000291484100011 PM 21479944 ER PT J AU Morrison, B Sidow, S McNally, K McPherson, J Chuang, A AF Morrison, Bradley Sidow, Stephanie McNally, Kathleen McPherson, James Chuang, Augustine TI An In Vitro Evaluation of the Growth of Human Periodontal Ligament Fibroblasts after Exposure to a 4-META-containing Methacrylate-based Endodontic Sealer SO JOURNAL OF ENDODONTICS LA English DT Article DE Human periodontal ligament fibroblasts; MetaSEAL; methacrylate resin-based sealer ID ROOT-CANAL SEALERS; SELF-ADHESIVE; RADIOGRAPHIC EVALUATION; CYTOTOXICITY EVALUATION; AH PLUS; RESIN; MICROSCOPY; RESISTANCE; CELLS; MODEL AB Introduction: In this study we evaluated the cytotoxic effects of MetaSEAL, a 4-META containing methacrylate-based endodontic sealer, on human periodontal ligament (HPDL) fibroblasts. There are a limited number of studies on the cytotoxic effects of MetaSEAL, and there are no studies on the cytotoxic effects of MetaSEAL on cells it might come into contact with in vivo. Methods: MetaSEAL concentrations of 25, 50, 100, 200, 400, and 800 mu g/mL were exposed to HPDL fibroblast cultures and evaluated at 1, 3, 7, 14, and 21 days. Controls included untreated cells and cells treated with ethanol, the vehicle for MetaSEAL suspension. Crystal violet staining in 24-well plates and the fluorescence-based CyQUANT Cell Proliferation Assay in 96-well plates assessed fibroblast viability. Results: Significant cytotoxicity against HPDL growth by MetaSEAL was both time- and concentration-dependent. At day 1 there were no significant cytotoxic effects, whereas by day 3, 800 mu g/mL concentration, by day 7, 200, 400, and 800 mu g/mL concentrations, and by day 14, 50, 100, 200, 400, and 800 mu g/mL concentrations were significantly cytotoxic. By day 21, all concentrations were significantly cytotoxic. These findings were confirmed by both the crystal violet and CyQUANT assays. Conclusions: MetaSEAL endodontic sealer has increasing HPDL cytotoxicity with both concentration and time exposure. (J Endod 2011;37:803-806) C1 [Morrison, Bradley; Sidow, Stephanie; McNally, Kathleen] USA, Endodont Residency Program, APO, AE 09034 USA. [McPherson, James; Chuang, Augustine] USA, Dept Clin Invest, Ft Gordon, GA USA. RP Morrison, B (reprint author), USA, Endodont Residency Program, CMR 405 Box 1203, APO, AE 09034 USA. EM bradley.morrison@us.army.mil NR 32 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 2011 VL 37 IS 6 BP 803 EP 806 DI 10.1016/j.joen.2011.02.026 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 778OF UT WOS:000291713300016 PM 21787493 ER PT J AU Wall, SJ Murphy, MJ Parish, LE AF Wall, Sarah J. Murphy, Michael J. Parish, Loraine E. TI Effects of mastery climate physical play on heart rate and physical activity of preschoolers in rural New Mexico SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY LA English DT Meeting Abstract C1 [Wall, Sarah J.; Murphy, Michael J.] Eastern New Mexico Univ, Portales, NM USA. [Parish, Loraine E.] USA, Aeromed Res Lab, Ft Rucker, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0895-2779 J9 J SPORT EXERCISE PSY JI J. Sport Exerc. Psychol. PD JUN PY 2011 VL 33 SU S BP S45 EP S45 PG 1 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 777LN UT WOS:000291619700082 ER PT J AU Ding, D Cooper, RA Pasquina, PF Fici-Pasquina, L AF Ding, Dan Cooper, Rory A. Pasquina, Paul F. Fici-Pasquina, Lavinia TI Sensor technology for smart homes SO MATURITAS LA English DT Review DE Smart homes; Sensor technology; Independent living; Aging; Disability AB A smart home is a residence equipped with technology that observes the residents and provides proactive services. Most recently, it has been introduced as a potential solution to support independent living of people with disabilities and older adults, as well as to relieve the workload from family caregivers and health providers. One of the key supporting features of a smart home is its ability to monitor the activities of daily living and safety of residents, and in detecting changes in their daily routines. With the availability of inexpensive low-power sensors, radios, and embedded processors, current smart homes are typically equipped with a large amount of networked sensors which collaboratively process and make deductions from the acquired data on the state of the home as well as the activities and behaviors of its residents. This article reviews sensor technology used in smart homes with a focus on direct environment sensing and infrastructure mediated sensing. The article also points out the strengths and limitations of different sensor technologies, as well as discusses challenges and opportunities from clinical, technical, and ethical perspectives. It is recommended that sensor technologies for smart homes address actual needs of all stake holders including end users, their family members and caregivers, and their doctors and therapists. More evidence on the appropriateness, usefulness, and cost benefits analysis of sensor technologies for smart homes is necessary before these sensors should be widely deployed into real-world residential settings and successfully integrated into everyday life and health care services. (C) 2011 Elsevier Ireland Ltd. All rights reserved. C1 [Ding, Dan; Cooper, Rory A.] VA Pittsburgh Healthcare Syst, Human Engn Res Labs, Pittsburgh, PA 15260 USA. [Ding, Dan; Cooper, Rory A.] Univ Pittsburgh, Dept Rehabil Sci & Technol, Pittsburgh, PA 15260 USA. [Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [Fici-Pasquina, Lavinia] Catholic Univ Amer, Dept Architecture, Washington, DC 20064 USA. RP Ding, D (reprint author), VA Pittsburgh Healthcare Syst, Human Engn Labs, 7180 Highland Dr,151R1-H, Pittsburgh, PA 15260 USA. EM dad5@pitt.edu FU National Science Foundation [EEC-0540865]; VA Center of Excellence for Wheelchairs and Associated Rehabilitation Engineering [B3142C] FX The work is supported in part by the Quality of Life Technology Engineering Research Center (EEC-0540865) funded by the National Science Foundation. The work is also supported by VA Center of Excellence for Wheelchairs and Associated Rehabilitation Engineering B3142C. The contents of this paper do not represent the views of the Department of Veterans Affairs or the United States Government. NR 44 TC 55 Z9 56 U1 9 U2 62 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-5122 J9 MATURITAS JI Maturitas PD JUN PY 2011 VL 69 IS 2 BP 131 EP 136 DI 10.1016/j.maturitas.2011.03.016 PG 6 WC Geriatrics & Gerontology; Obstetrics & Gynecology SC Geriatrics & Gerontology; Obstetrics & Gynecology GA 780EP UT WOS:000291837600008 PM 21531517 ER PT J AU Convertino, VA Ryan, KL Rickards, CA Glorsky, SL Idris, AH Yannopoulos, D Metzger, A Lurie, KG AF Convertino, Victor A. Ryan, Kathy L. Rickards, Caroline A. Glorsky, Steven L. Idris, Ahamed H. Yannopoulos, Demetris Metzger, Anja Lurie, Keith G. TI Optimizing the Respiratory Pump: Harnessing Inspiratory Resistance to Treat Systemic Hypotension SO RESPIRATORY CARE LA English DT Review DE hemorrhagic shock; lower-body negative pressure; intrathoracic pressure; impedance threshold device; cardiovascular collapse ID IMPEDANCE THRESHOLD DEVICE; HOSPITAL CARDIAC-ARREST; DECOMPRESSION CARDIOPULMONARY-RESUSCITATION; INTRATHORACIC PRESSURE REGULATION; ORGAN PERFUSION PRESSURES; BODY NEGATIVE-PRESSURE; CEREBRAL-BLOOD-FLOW; PORCINE MODEL; CENTRAL HYPOVOLEMIA; ORTHOSTATIC HYPOTENSION AB We review the physiology and affects of inspiration through a low level of added resistance for the treatment of hypotension. Recent animal and clinical studies demonstrated that one of the body's natural response mechanisms to hypotension is to harness the respiratory pump to increase circulation. That finding is consistent with observations, in the 1960s, about the effect of lowering intrathoracic pressure on key physiological and hemodynamic variables. We describe studies that focused on the fundamental relationship between the generation of negative intrathoracic pressure during inspiration through a low level of resistance created by an impedance threshold device and the physiologic sequelae of a respiratory pump. A decrease in intrathoracic pressure during inspiration through a fixed resistance resulting in a pressure difference of 7 cm H(2)O has multiple physiological benefits, including: enhanced venous return and cardiac stroke volume, lower intracranial pressure, resetting of the cardiac baroreflex, elevated cerebral blood flow oscillations, increased tissue blood flow/pressure gradient, and maintenance of the integrity of the baroreflex-mediated coherence between arterial pressure and sympathetic nerve activity. While breathing has traditionally been thought primarily to provide gas exchange, studies of the mechanisms involved in animals and humans provide the physiological underpinnings for "the other side of breathing": to increase circulation to the heart and brain, especially in the setting of physiological stress. The existing results support the use of the intrathoracic pump to treat clinical conditions associated with hypotension, including orthostatic hypotension, hypotension during and after hemodialysis, hemorrhagic shock, heat stroke, septic shock, and cardiac arrest. Harnessing these fundamental mechanisms that control cardiopulmonary physiology provides new opportunities for respiratory therapists and others who have traditionally focused on ventilation to also help treat serious and often life-threatening circulatory disorders. C1 [Convertino, Victor A.; Ryan, Kathy L.; Glorsky, Steven L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA. [Idris, Ahamed H.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA. [Idris, Ahamed H.] Univ Texas SW Med Ctr Dallas, Dept Emergency Med, Dallas, TX 75390 USA. [Yannopoulos, Demetris; Metzger, Anja; Lurie, Keith G.] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN 55415 USA. [Metzger, Anja; Lurie, Keith G.] Adv Circulatory Syst, Roseville, MN USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil OI Idris, Ahamed/0000-0001-7113-6499 NR 54 TC 18 Z9 19 U1 0 U2 7 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD JUN PY 2011 VL 56 IS 6 BP 846 EP 857 DI 10.4187/respcare.01018 PG 12 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 779LQ UT WOS:000291779500014 PM 21333089 ER PT J AU Ergunay, K Whitehouse, CA Ozkul, A AF Ergunay, Koray Whitehouse, Chris A. Ozkul, Aykut TI Current Status of Human Arboviral Diseases in Turkey SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Anatolia; Arbovirus; Crimean-Congo hemorrhagic fever, CCHF; Dengue, DENV; Sandfly fever virus, SFV; Tick-borne encephalitis, TBE; Turkey; West Nile virus, WNV ID CONGO HEMORRHAGIC-FEVER; WEST-NILE-VIRUS; TICK-BORNE ENCEPHALITIS; SANDFLY FEVER; SEROLOGICAL EVIDENCE; CHIKUNGUNYA VIRUS; AEDES-ALBOPICTUS; GENETIC-ANALYSIS; INFECTIONS; EUROPE AB Infections caused by viruses transmitted via blood-feeding arthropods (arthropod-borne or arboviruses) have gained considerable attention and importance during the last decades due to their resurgence, impact on public health, and changing epidemiologic features. The complex transmission cycles affected by environmental, technological, and ecological changes place arboviral infections in the realm of emerging and reemerging infections that intermittantly reappear in epidemic form or display tendency to expend beyond endemic zones. A number of previously undetected arboviral diseases have emerged in Turkey during the last decade, although, in some cases, serologic evidence has been provided earlier. Since Crimean-Congo hemorrhagic fever first emerged in Turkey in 2002, there are now more than 4400 laboratory-confirmed cases of the disease. In addition, convincing evidence has accumulated to suggest that pathogenic flaviviruses, including West Nile virus, are in circulation. Recent studies have also revealed human exposure, central nervous system infections, and outbreaks of febrile diseases by sandfly fever viruses. In this study, reports published in local and international journals on surveillance and epidemiology of medically important arboviruses and associated diseases from Turkey have been reviewed, and current data on tick, mosquito, and sandfly vectors are incorporated. C1 [Ergunay, Koray] Hacettepe Univ, Fac Med, Dept Med Microbiol, Virol Unit, TR-06100 Ankara, Turkey. [Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Ozkul, Aykut] Ankara Univ, Fac Vet Med, Dept Virol, TR-06100 Ankara, Turkey. RP Ergunay, K (reprint author), Hacettepe Univ, Fac Med, Dept Med Microbiol, Virol Unit, Morphol Bldg,3rd Floor, TR-06100 Ankara, Turkey. EM ekoray@hacettepe.edu.tr RI ERGUNAY, KORAY/I-8368-2013 OI ERGUNAY, KORAY/0000-0001-5422-1982 NR 77 TC 23 Z9 23 U1 0 U2 9 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUN PY 2011 VL 11 IS 6 BP 731 EP 741 DI 10.1089/vbz.2010.0162 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 778PV UT WOS:000291717500021 PM 21133776 ER PT J AU Scofield, DE McClung, HL McClung, JP Kraemer, WJ Rarick, KR Pierce, JR Cloutier, GJ Fielding, RA Matheny, RW Young, AJ Nindl, BC AF Scofield, D. E. McClung, H. L. McClung, J. P. Kraemer, W. J. Rarick, K. R. Pierce, J. R. Cloutier, G. J. Fielding, R. A. Matheny, R. W., Jr. Young, A. J. Nindl, B. C. TI A novel, noninvasive transdermal fluid sampling methodology: IGF-I measurement following exercise SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE autocrine; paracrine; resistance exercise; transdermal fluid ID GROWTH-FACTOR-I; HEAVY-RESISTANCE EXERCISE; INCREASED PHYSICAL-ACTIVITY; BINDING-PROTEINS; SKELETAL-MUSCLE; BODY-COMPOSITION; FACTOR RESPONSES; SYSTEM; MICRODIALYSIS; ENERGY AB This study tested the hypothesis that transdermal fluid (TDF) provides a more sensitive and accurate measure of exercise-induced increases in insulin-like growth factor-I (IGF-I) than serum, and that these increases are detectable proximal, but not distal, to the exercising muscle. A novel, noninvasive methodology was used to collect TDF, followed by sampling of total IGF-I (tIGF-I) and free IGF-I (fIGF-I) in TDF and serum following an acute bout of exercise. Experiment 1: eight men (23 +/- 3 yrs, 79 +/- 7 kg) underwent two conditions (resting and 60 min of cycling exercise at 60% (V) over dotO(2peak)) in which serum and forearm TDF were collected for comparison. There were no significant changes in tIGF-I or fIGF-I in TDF obtained from the forearm or from serum following exercise (P > 0.05); however, the proportion of fIGF-I to tIGF-I in TDF was approximately fourfold greater than that of serum (P > 0.05). These data suggest that changes in TDF IGF-I are not evident when TDF is sampled distal from the working tissue. To determine whether exercise-induced increases in local IGF-I could be detected when TDF was sampled directly over the active muscle group, we performed a second experiment. Experiment 2: fourteen subjects (22 +/- 4 yr, 68 +/- 11 kg) underwent an acute plyometric exercise condition consisting of 10 sets of 10 plyometric jumps with 2-min rest between sets. We observed a significant increase in TDF tIGF-I following exercise (P <= 0.05) but no change in serum tIGF-I (P > 0.05). Overall, these data suggest that TDF may provide a noninvasive means of monitoring acute exercise-induced changes in local IGF-I when sampled in proximity to exercising muscles. Moreover, our finding that the proportion of free to tIGF-I was greater in TDF than in serum suggests that changes in local IGF-I may be captured more readily using this system. C1 [Scofield, D. E.; Rarick, K. R.; Pierce, J. R.; Matheny, R. W., Jr.; Nindl, B. C.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Scofield, D. E.; Rarick, K. R.; Pierce, J. R.; Matheny, R. W., Jr.; Nindl, B. C.] USA, Div Nutr, Environm Med Res Inst, Natick, MA 01760 USA. [Kraemer, W. J.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT USA. [Kraemer, W. J.] Univ Connecticut, Dept Physiol & Neurobiol, Human Performance Lab, Storrs, CT 06269 USA. [Cloutier, G. J.; Fielding, R. A.] Tufts Univ, Sarcopenia Lab, Boston, MA 02111 USA. RP Nindl, BC (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil RI Matheny, Ronald/I-9336-2012; McClung, James/A-1989-2009; SCOFIELD, DENNIS/F-3636-2015 OI Matheny, Ronald/0000-0001-7378-0560; FU U.S. Department of Agriculture [58-1950-7-707]; U.S. Army Medical Research and Materiel Command FX This material is based upon work supported by the U.S. Department of Agriculture, under agreement no. 58-1950-7-707 and by funding from the U.S. Army Medical Research and Materiel Command to Task Area 5: Physiological Mechanisms of Musculoskeletal Injury. NR 29 TC 3 Z9 3 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUN PY 2011 VL 300 IS 6 BP R1326 EP R1332 DI 10.1152/ajpregu.00313.2010 PG 7 WC Physiology SC Physiology GA 776KA UT WOS:000291532000009 PM 21389329 ER PT J AU Angov, E AF Angov, Evelina TI Codon usage: Nature's roadmap to expression and folding of proteins SO BIOTECHNOLOGY JOURNAL LA English DT Review DE Codon usage; Protein folding; Translation ID TRANSFER-RNA ABUNDANCE; HIGH-LEVEL EXPRESSION; RIBOSOMAL EXIT TUNNEL; ESCHERICHIA-COLI; MESSENGER-RNA; BACTERIAL EXPRESSION; SECONDARY STRUCTURE; TRANSLATIONAL EFFICIENCY; PLASMODIUM-FALCIPARUM; HETEROLOGOUS PROTEINS AB Biomedical and biotechnological research relies on processes leading to the successful expression and production of key biological products. High-quality proteins are required for many purposes, including protein structural and functional studies. Protein expression is the culmination of multistep processes involving regulation at the level of transcription, mRNA turnover, protein translation, and post-translational modifications leading to the formation of a stable product. Although significant strides have been achieved over the past decade, advances toward integrating genomic and proteomic information are essential, and until such time, many target genes and their products may not be fully realized. Thus, the focus of this review is to provide some experimental support and a brief overview of how codon usage bias has evolved relative to regulating gene expression levels. C1 Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Angov, E (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Evelina.angov@us.army.mil FU United States Agency for International Development [936-6001, AAG-P-00-98-00006, AAG-P-00-98-00005]; United States Army Medical Research and Materiel Command FX This work was supported by the United States Agency for International Development, Project Number 936-6001, Award Number AAG-P-00-98-00006, Award Number AAG-P-00-98-00005, and by the United States Army Medical Research and Materiel Command. The author acknowledges Drs. Malabi Venkatesan, Elke Bergmann-Leitner, and Anjali Yadava for critical reading and comments on this article; Drs. Jeff Lyon and Randall Kincaid, for their role in the collaboration on the development of the algorithm, codon harmonization; and Dr. Farhat Khan for his partnership on the development of recombinant, soluble malaria proteins. NR 108 TC 61 Z9 63 U1 4 U2 41 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1860-6768 J9 BIOTECHNOL J JI Biotechnol. J. PD JUN PY 2011 VL 6 IS 6 SI SI BP 650 EP 659 DI 10.1002/biot.201000332 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 776NP UT WOS:000291542500005 PM 21567958 ER PT J AU Cheuvront, SN Fraser, CG Kenefick, RW Ely, BR Sawka, MN AF Cheuvront, Samuel N. Fraser, Callum G. Kenefick, Robert W. Ely, Brett R. Sawka, Michael N. TI Reference change values for monitoring dehydration SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE LA English DT Article DE biological variation; hydration assessment; index of individuality; population reference interval ID BIOLOGICAL VARIATION; OLDER-ADULTS; CLINICAL-CHEMISTRY; MEDICAL STATISTICS; SERUM OSMOLALITY; HYDRATION STATUS; PROBABILITY; LANGUAGE; PEOPLE; PLASMA AB Background: Dehydration is a common medical problem requiring heuristic evaluation. Our aim was to develop a quantitative and graphical tool based on serial changes in either plasma osmolality (P(osm)), urine specific gravity (U(sg)), or body mass (B(m)) to aid in determining the probability that a person has become dehydrated. A secondary purpose was to validate use of the tool by dehydrating a group of volunteers. Methods: Basic data were obtained from a recent study of biological variation in common hydration status markers. Four reference change values (RCV) were calculated for each variable (P(osm), U(sg), B(m)) using four statistical probabilities (0.80, 0.90, 0.95, and 0.99). The probability derived from the Z-score for any given change can be calculated from: Zschange/[2(1/2)(CV(a)(2) + CV(i)(2))(1/2)]. This calculation was simplified to require one input (measured change) by plotting the RCV against probability to generate both an empirical equation and a dual quantitative-qualitative graphic. Results: Eleven volunteers were dehydrated by moderate levels (-2.1% to -3.5% B(m)). Actual probabilities were obtained by substituting measured changes in P(osm), U(sg), and B(m) for X in the exponential equation, Y=1-e(-K+X), where each variable has a unique K constant. Median probabilities were 0.98 (P(osm)), 0.97 (U(sg)), and 0.97 (B(m)), which aligned with 'very likely' to 'virtually certain' qualitative probability categories for dehydration. Conclusions: This investigation provides a simple quantitative and graphical tool that can aid in determining the probability that a person has become dehydrated when serial measures of P(osm), U(sg), or B(m) are made. C1 [Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Fraser, Callum G.] Scottish Bowel Screening Ctr Lab, Dundee, Scotland. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Samuel.n.cheuvront@us.army.mil FU United States Army Medical Research and Materiel Command (USMRMC) FX This work was supported by the United States Army Medical Research and Materiel Command (USMRMC). NR 41 TC 25 Z9 25 U1 0 U2 5 PU WALTER DE GRUYTER & CO PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 1434-6621 J9 CLIN CHEM LAB MED JI Clin. Chem. Lab. Med. PD JUN PY 2011 VL 49 IS 6 BP 1033 EP 1037 DI 10.1515/CCLM.2011.170 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 775AU UT WOS:000291429500016 PM 21428854 ER PT J AU Lentine, KL Axelrod, D Abbotta, KC AF Lentine, Krista L. Axelrod, David Abbotta, Kevin C. TI Interpreting Body Composition in Kidney Transplantation: Weighing Candidate Selection, Prognostication, and Interventional Strategies to Optimize Health SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Editorial Material ID STAGE RENAL-DISEASE; MASS INDEX; IMPACT; RECIPIENTS; MORTALITY; SURVIVAL; FAILURE C1 [Lentine, Krista L.] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Axelrod, David] Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. [Abbotta, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 4th Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentinek@slu.edu OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K08DK073036] NR 16 TC 11 Z9 11 U1 0 U2 2 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD JUN PY 2011 VL 6 IS 6 BP 1238 EP 1240 DI 10.2215/CJN.02510311 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 775YY UT WOS:000291500900004 PM 21566111 ER PT J AU Yoshitani, G AF Yoshitani, Gail TI Tear Down This Wall: A City, a President, and the Speech that Ended the Cold War. SO HISTORIAN LA English DT Book Review C1 [Yoshitani, Gail] US Mil Acad, West Point, NY 10996 USA. RP Yoshitani, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 2011 VL 73 IS 2 BP 357 EP 358 PG 2 WC History SC History GA 774PF UT WOS:000291397900035 ER PT J AU Albright, JM Raja, LL Manley, M Ravi-Chandar, K Satapathy, S AF Albright, J. M. Raja, L. L. Manley, M. Ravi-Chandar, K. Satapathy, S. TI Studies of Asperity-Scale Plasma Discharge Phenomena SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Electrical breakdown; electrical contact at asperity scale; microdischarge; Paschen curve ID SIMULATION; EMISSION AB A combined experimental and computational simulation study of direct-current plasma discharge phenomena in small-length-scale geometries (< 10 mu m) is described. The primary goal is to study discharge breakdown characteristics in small-length-scale geometries as quantified by a modified Paschen breakdown curve and the quench characteristics in these discharges. A modified mesoscale friction tester apparatus is used for the experiments. A self-consistent nonequilibrium plasma model is used for the simulation studies. The model includes field-emission effects, which is a key process in determining small-length-scale breakdown behavior. The breakdown and quench curves obtained from the experiments and simulations showed the same general trends. Quantification of the heat fluxes from the simulations shows higher erosion at the cathode and a highly nonlinear heating behavior with applied overvoltages above the breakdown threshold. C1 [Albright, J. M.; Raja, L. L.; Manley, M.; Ravi-Chandar, K.] Univ Texas Austin, Austin, TX 78712 USA. [Satapathy, S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Albright, JM (reprint author), Univ Texas Austin, Austin, TX 78712 USA. EM jmalbright@mail.utexas.edu; lraja@mail.utexas.edu; manley.matthew@gmail.com; kravi@mail.utexas.edu; sikhanda.s.satapathy@us.army.mil RI Ravi-Chandar, Krishnaswamy/D-9246-2011; Satapathy, Sikhanda/L-5264-2015 FU Office of Naval Research [N00014-04-1-0599] FX This work was supported by the Office of Naval Research under Award N00014-04-1-0599. Any opinions, findings, and conclusions or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the Office of Naval Research. NR 20 TC 2 Z9 2 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JUN PY 2011 VL 39 IS 6 BP 1560 EP 1565 DI 10.1109/TPS.2011.2141689 PN 2 PG 6 WC Physics, Fluids & Plasmas SC Physics GA 776PX UT WOS:000291550400016 ER PT J AU Behner, T Anderson, CE Holmquist, TJ Orphal, DL Wickert, M Templeton, DW AF Behner, Th. Anderson, C. E., Jr. Holmquist, T. J. Orphal, D. L. Wickert, M. Templeton, D. W. TI Penetration dynamics and interface defeat capability of silicon carbide against long Rod impact SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT Symposium on Hypervelocity Impact CY APR 11-15, 2010 CL Freiburg, GERMANY DE Long rod penetration; Interface defeat; Silicon carbide; Penetration mechanics ID TUNGSTEN PROJECTILES; TRANSITION; TARGETS AB To determine the behavior of silicon carbide (SiC) against long rod impact a detailed study with experiments in the velocity range from 0.8 to 3 km/s at normal impact conditions was performed in recent years. Interest ranged from penetration performance of intact and pre-damaged SiC to interface defeat capability of SiC. Together with impact data in the hypervelocity regime this paper provides a comprehensive overview of the penetration dynamics of SiC over a wide velocity range and during different phases of the penetration process. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Behner, Th.; Wickert, M.] EMI, Fraunhofer Inst High Speed Dynam, D-79104 Freiburg, Germany. [Anderson, C. E., Jr.] SW Res Inst, San Antonio, TX 78228 USA. [Holmquist, T. J.] SW Res Inst, Minneapolis, MN 55416 USA. [Orphal, D. L.] Int Res Associates Inc, Pleasanton, CA 94566 USA. [Templeton, D. W.] USA, RDECOM TACOM, AMSTA TR, Warren, MI 48397 USA. RP Behner, T (reprint author), EMI, Fraunhofer Inst High Speed Dynam, Eckerstr 4, D-79104 Freiburg, Germany. EM Behner@emi.fhg.de NR 13 TC 13 Z9 13 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUN PY 2011 VL 38 IS 6 SI SI BP 419 EP 425 DI 10.1016/j.ijimpeng.2010.10.011 PG 7 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 773VB UT WOS:000291338300004 ER PT J AU Singleton, L AF Singleton, Lisa TI Perinatal Support: Helping Pregnant Women Fight Mood and Anxiety Disorders SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Meeting Abstract DE perinatal depression; postpartum; postpartum depression; perinatal support; depression; cognitive behavioral therapy C1 [Singleton, Lisa] Reynolds Army Community Hosp, Dept Specialty Care Clin, Ft Sill, OK USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0884-2175 J9 JOGNN-J OBST GYN NEO JI JOGNN PD JUN PY 2011 VL 40 SU 1 SI SI BP S12 EP S12 PG 1 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA 773IW UT WOS:000291301200017 ER PT J AU Trego, LL AF Trego, Lori Lyn TI Advanced Practice Nursing Intervention: Improving Women's Health in the Combat Zone SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Meeting Abstract DE military women's health; feminine hygiene C1 [Trego, Lori Lyn] Tripler Army Med Ctr, Nursing Res Serv, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0884-2175 J9 JOGNN-J OBST GYN NEO JI JOGNN PD JUN PY 2011 VL 40 SU 1 SI SI BP S91 EP S92 PG 3 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA 773IW UT WOS:000291301200130 ER PT J AU Ely, MR Kenefick, RW Cheuvront, SN Chinevere, TD Lacher, CP Lukaski, HC Montain, SJ AF Ely, Matthew R. Kenefick, Robert W. Cheuvront, Samuel N. Chinevere, Troy D. Lacher, Craig P. Lukaski, Henry C. Montain, Scott J. TI Surface contamination artificially elevates initial sweat mineral concentrations SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE zinc; iron; copper; calcium; electrolytes ID EXERCISE-HEAT STRESS; WHOLE-BODY; ZINC CONCENTRATIONS; PROLONGED EXERCISE; TRACE-ELEMENTS; LOSSES; IRON; COLLECTION; COPPER; SKIN AB Several sweat mineral element concentrations decline with serial sampling. Possible causes include reduced dermal mineral concentrations or flushing of surface contamination. The purpose of this study was to simultaneously sample mineral concentrations in transdermal fluid (TDF), sweat, and serum during extended exercise-heat stress to determine if these compartments show the same serial changes during repeat sampling. Sixteen heat-acclimated individuals walked on a treadmill (1.56 m/s, 3.0% grade) in a 35 degrees C, 20% relative humidity (RH), 1 m/s wind environment 50 min each hour for 3 h. Mineral concentrations of Ca, Cu, Fe, K, Mg, Na, and Zn were measured each hour from serum, sweat from upper back (sweat pouch) and arm (bag), and TDF from the upper back. Sites were meticulously cleaned to minimize surface contamination. Mineral concentrations were determined by spectrometry. TDF remained stable over time, with exception of a modest increase in TDF [Fe] (15%) and decrease in TDF [Zn] (-18%). Likewise, serum and pouch sweat samples were stable over time. In contrast, the initial arm bag sweat mineral concentrations were greater than those in the sweat pouch, and [Ca], [Cu], [Mg], and [Zn] declined 26-76% from initial to the subsequent samples, becoming similar to sweat pouch. Nominal TDF mineral shifts do not affect sweat mineral concentrations. Arm bag sweat mineral concentrations are initially elevated due to skin surface contaminants that are not removed despite meticulous cleaning (e. g., under fingernails, on arm hair), then decrease with extended sweating and approach those measured from the scapular region. C1 [Ely, Matthew R.; Kenefick, Robert W.; Cheuvront, Samuel N.; Chinevere, Troy D.; Montain, Scott J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Lacher, Craig P.; Lukaski, Henry C.] USDA, Human Nutr Res Ctr, Grand Forks, ND USA. RP Ely, MR (reprint author), USA, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM matthew.ely@us.army.mil OI Ely, Matthew/0000-0002-0618-7078 NR 41 TC 5 Z9 5 U1 2 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 2011 VL 110 IS 6 BP 1534 EP 1540 DI 10.1152/japplphysiol.01437.2010 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 776KG UT WOS:000291532600007 PM 21512152 ER PT J AU Melamed, BG Cubic, BA AF Melamed, Barbara G. Cubic, Barbara Ann TI Strengthening Our Soldiers (SOS) and Their Families: Contemporary Psychological Advances Applied to Wartime Problems. Why Now? Why Us? What Next? SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Editorial Material ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ WAR VETERANS; HEALTH-CARE; SYMPTOMS; PREVALENCE; DEPLOYMENT; COMBAT; IMPACT; ARMY C1 [Cubic, Barbara Ann] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23507 USA. [Melamed, Barbara G.] Tripler Army Med Ctr, Dept Psychol, Clin Heath Psychol Postdoctoral Fellowship Progra, Honolulu, HI 96859 USA. RP Cubic, BA (reprint author), Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23507 USA. EM barbara@drmelamed.net; cubicba@evms.edu NR 29 TC 0 Z9 0 U1 1 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD JUN PY 2011 VL 18 IS 2 BP 109 EP 115 DI 10.1007/s10880-011-9245-4 PG 7 WC Psychology, Clinical SC Psychology GA 775SQ UT WOS:000291484100001 PM 21812128 ER EF