FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Ryan, KL
Rickards, CA
Hinojosa-Laborde, C
Cooke, WH
Convertino, VA
AF Ryan, Kathy L.
Rickards, Caroline A.
Hinojosa-Laborde, Carmen
Cooke, William H.
Convertino, Victor A.
TI Arterial pressure oscillations are not associated with muscle
sympathetic nerve activity in individuals exposed to central
hypovolaemia
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID HEART PERIOD VARIABILITY; POWER SPECTRAL-ANALYSIS; BODY
NEGATIVE-PRESSURE; BLOOD-PRESSURE; CARDIOVASCULAR VARIABILITY;
SYMPATHOVAGAL INTERACTION; NEURAL REGULATION; MAYER WAVES; R-R; HUMANS
AB The spectral power of low frequency oscillations of systolic arterial pressure (SAP(LF)) has been used as a non-invasive surrogate of muscle sympathetic nerve activity (MSNA) in both experimental and clinical situations. For SAP(LF) to be used in this way, a relationship must exist between SAP(LF) and MSNA within individuals during sympathetic activation. Using progressive central hypovolaemia to induce sympathetic activation, we hypothesised that SAP(LF) would correlate with MSNA in all subjects. ECG, beat-by-beat arterial pressure and MSNA were recorded in humans (n = 20) during a progressive lower body negative pressure (LBNP) protocol designed to cause presyncope in all subjects. Arterial pressure oscillations were assessed in the low frequency (LF; 0.04-0.15 Hz) domain using a Fourier transform. For the entire group, SAPLF, MSNA burst frequency, and total MSNA increased during LBNP. Values for coefficients of determination (r(2)) describing the linear associations of SAP(LF) with MSNA burst frequency and total MSNA were 0.73 and 0.84, but rose to 0.89 and 0.98 when curvilinear fits were used, indicating that the relationship is curvilinear rather than linear. Associations between SAP(LF) and MSNA within each individual subject, however, varied widely for both MSNA burst frequency and total MSNA, whether derived by linear (r(2) range, 1.7x 10(-6) to 0.99) or polynomial (r(2) range, 0.09 to 1.0) regression analysis. Similar results were obtained when relationships between low frequency oscillations in diastolic arterial pressure and MSNA were evaluated. These results do not support the use of low frequency oscillations in arterial pressure as a non-invasive measure of sympathetic outflow for individual subjects during sympathetic activation.
C1 [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA.
RP Ryan, KL (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM kathy.ryan@amedd.army.mil
FU United States Army, Medical Research and Materiel Command
FX We thank the research volunteers for their cheerful participation and Mr
Gary Muniz for his excellent laboratory assistance. This study was
funded by the United States Army, Medical Research and Materiel Command.
NR 44
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U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD NOV
PY 2011
VL 589
IS 21
BP 5311
EP 5322
DI 10.1113/jphysiol.2011.213074
PG 12
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 839MA
UT WOS:000296369000025
PM 21930599
ER
PT J
AU Lin, JL
Moore, JJ
Sproul, WD
Lee, SL
AF Lin, Jianliang
Moore, John J.
Sproul, William D.
Lee, S. L.
TI Effects of the magnetic field strength on the modulated pulsed power
magnetron sputtering of metallic films
SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
LA English
DT Article
DE aluminium; chromium; copper; grain size; ionisation; magnetic field
effects; metallic thin films; positive ions; sputter deposition;
tantalum; titanium
ID ION ENERGY; DEPOSITION; COATINGS; PLASMA; TECHNOLOGY; DISCHARGE;
DISTRIBUTIONS; FLUX
AB The influence of the magnetic field strength (B) on the deposition rate and plasma properties for Ta, Cr, Ti, Al, Cu materials using the modulated pulsed power (MPP) magnetron sputtering technique in a closed field unbalanced magnetron sputtering system was investigated. The MPP deposition rates were compared to those obtained from the films deposited by direct current magnetron sputtering (DCMS) under similar experimental conditions. The time averaged ion energy and mass distributions of positive ions in the MPP plasmas at different magnetic field strengths were compared, using a Hiden electrostatic quadrupole plasma mass spectrometer. The effects of the repetition frequency and pulse length on the MPP deposition rate were investigated. For a given target power, the MPP deposition rate increased when the repetition frequency was increased. It also increased as the pulse length was increased at a constant repetition frequency and target power. The MPP deposition rate is strongly material dependent. The MPP deposition rate increased as B decreased for a given target power. For a B of 550 G, the R-MPP/R-DCMS ratio for Cu was in a range of 0.81-1.02, for Al it was 0.84-1.01, for Cr it was 0.64-1.01, for Ti it was 0.52-0.89, and for Ta it was 0.47-0.84. For a B of 350 G, the R-MPP/R-DCMS ratio for Cu was increased to 1.03-1.07, for Al it was 0.94-1.04, for Cr it was 0.8-1.03, for Ti it was 0.79-0.94, and for Ta it was 0.72-0.88. However, a decrease in the ionization of metal and gas species was observed as B was decreased, which affected the microstructure and mechanical properties of the deposited Cr films. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3645612]
C1 [Lin, Jianliang; Moore, John J.] Colorado Sch Mines, Dept Met & Mat Engn, Adv Coatings & Surface Engn Lab ACSEL, Golden, CO 80401 USA.
[Sproul, William D.] React Sputtering Inc, San Marcos, CA 92078 USA.
[Lee, S. L.] USA, ARDEC Benet Labs, Watervliet, NY 12189 USA.
RP Lin, JL (reprint author), Colorado Sch Mines, Dept Met & Mat Engn, Adv Coatings & Surface Engn Lab ACSEL, Golden, CO 80401 USA.
EM bsproul@cox.net
RI Lin, Jianliang/F-8405-2012
FU Department of Energy (DOE); Army's Benet Laboratory
FX The authors are thankful for support of the research work by the
Department of Energy (DOE) and the Army's Benet Laboratory, and
recognize and greatly appreciate the technical support of the MPP
sputtering from Zpulser, LLC.
NR 38
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U1 1
U2 21
PU A V S AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0734-2101
J9 J VAC SCI TECHNOL A
JI J. Vac. Sci. Technol. A
PD NOV
PY 2011
VL 29
IS 6
AR 061301
DI 10.1116/1.3645612
PG 9
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA 843HQ
UT WOS:000296663300008
ER
PT J
AU Chang, MH
Pang, T
Yang, YP
AF Chang, Mou-Hsiung
Pang, Tao
Yang, Yipeng
TI A Stochastic Portfolio Optimization Model with Bounded Memory
SO MATHEMATICS OF OPERATIONS RESEARCH
LA English
DT Article
DE stochastic delay equations; optimal stochastic control;
Hamilton-Jacobi-Bellman equation
ID CONSUMPTION; INVESTMENT; EQUATIONS; SYSTEMS; DELAY
AB This paper considers a portfolio management problem of Merton's type in which the risky asset return is related to the return history. The problem is modeled by a stochastic system with delay. The investor's goal is to choose the investment control as well as the consumption control to maximize his total expected, discounted utility. Under certain situations, we derive the explicit solutions in a finite dimensional space.
C1 [Chang, Mou-Hsiung] USA, Div Math, Res Off, Res Triangle Pk, NC 27709 USA.
[Pang, Tao] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA.
[Yang, Yipeng] Univ Missouri Columbia, Dept Math, Columbia, MO 65211 USA.
RP Chang, MH (reprint author), USA, Div Math, Res Off, Res Triangle Pk, NC 27709 USA.
EM mouhsiung.chang@us.army.mil; tpang@ncsu.edu; yangyip@missouri.edu
FU U.S. Army Research Office [W911NF-04-D-0003]
FX The research of this paper is partially supported by Grant
W911NF-04-D-0003 from the U.S. Army Research Office. The authors thank
the two anonymous referees for many invaluable comments and suggestions.
NR 18
TC 10
Z9 10
U1 0
U2 2
PU INFORMS
PI HANOVER
PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA
SN 0364-765X
J9 MATH OPER RES
JI Math. Oper. Res.
PD NOV
PY 2011
VL 36
IS 4
BP 604
EP 619
DI 10.1287/moor.1110.0508
PG 16
WC Operations Research & Management Science; Mathematics, Applied
SC Operations Research & Management Science; Mathematics
GA 847MT
UT WOS:000296977700002
ER
PT J
AU Heiner, JD
Bullard-Berent, JH
Inbar, S
AF Heiner, Jason D.
Bullard-Berent, Jeffrey H.
Inbar, Shmuel
TI Deadly Proposal A Case of Catecholaminergic Polymorphic Ventricular
Tachycardia
SO PEDIATRIC EMERGENCY CARE
LA English
DT Article
DE catecholaminergic polymorphic ventricular tachycardia; CPVT; ventricular
tachycardia; sudden death; clinical genetics
ID CARDIAC RYANODINE RECEPTOR; SUDDEN UNEXPLAINED DEATH; BRUGADA-SYNDROME;
MOLECULAR AUTOPSY; FOLLOW-UP; ARREST; MUTATIONS; CHILDREN; SYNCOPE;
DIAGNOSIS
AB Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare adrenergically mediated arrhythmogenic disorder classically induced by exercise or emotional stress and found in structurally normal hearts. It is an important cause of cardiac syncope and sudden death in childhood. Catecholaminergic polymorphic ventricular tachycardia is a genetic cardiac channelopathy with known mutations involving genes affecting intracellular calcium regulation. We present a case of a 14-year-old boy who had cardiopulmonary arrest after an emotionally induced episode of CPVT while attempting to invite a girl to the school dance. Review of his presenting cardiac rhythm, induction of concerning ventricular arrhythmias during an exercise stress test, and genetic testing confirmed the diagnosis of CPVT. He recovered fully and was treated with beta-blocker therapy and placement of an implantable cardioverter-defibrillator. In this report, we discuss this rare but important entity, including its molecular foundation, clinical presentation, basics of diagnosis, therapeutic options, and implications of genetic testing for family members. We also compare CPVT to other notable cardiomyopathic and channelopathic causes of sudden death in youth including hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia, long QT syndrome, short QT syndrome, and Brugada syndrome.
C1 [Heiner, Jason D.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA.
[Bullard-Berent, Jeffrey H.] Mary Bridge Childrens Hosp, Dept Emergency Med, Tacoma, WA USA.
[Bullard-Berent, Jeffrey H.] Univ New Mexico, Div Cardiol, Dept Emergency Med, Albuquerque, NM 87131 USA.
[Inbar, Shmuel] Univ New Mexico, Div Cardiol, Dept Internal Med, Albuquerque, NM 87131 USA.
RP Heiner, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Houston, TX 78234 USA.
EM jason.heiner1@us.army.mil
NR 36
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0749-5161
J9 PEDIATR EMERG CARE
JI Pediatr. Emerg. Care
PD NOV
PY 2011
VL 27
IS 11
BP 1065
EP 1068
DI 10.1097/PEC.0b013e3182360606
PG 4
WC Emergency Medicine; Pediatrics
SC Emergency Medicine; Pediatrics
GA 844RB
UT WOS:000296763900013
PM 22068070
ER
PT J
AU Smith, C
Cardile, AP
Miller, M
AF Smith, Carin
Cardile, Anthony P.
Miller, Michael
TI Bath Salts as a "Legal High"
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Smith, Carin; Cardile, Anthony P.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA.
[Miller, Michael] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA.
RP Cardile, AP (reprint author), Tripler Army Med Ctr, Dept Internal Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM anthony.cardile@us.army.mil
NR 4
TC 10
Z9 10
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9343
J9 AM J MED
JI Am. J. Med.
PD NOV
PY 2011
VL 124
IS 11
BP E7
EP E8
DI 10.1016/j.amjmed.2011.03.014
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 842EW
UT WOS:000296576200004
PM 21514917
ER
PT J
AU Gruber, DD
Warner, WB
Lombardini, ED
Zahn, CM
Buller, JL
AF Gruber, Daniel D.
Warner, William B.
Lombardini, Eric D.
Zahn, Christopher M.
Buller, Jerome L.
TI Laparoscopic hysterectomy using various energy sources in swine: a
histopathologic assessment
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article; Proceedings Paper
CT 37th Annual Scientific Meeting of the Society-of-Gynecologic-Surgeons
CY APR 11-13, 2011
CL San Antonio, TX
SP Soc Gynecol Surg
DE energy source; histology; laparoscopic hysterectomy; swine; vagina
ID VAGINAL CUFF DEHISCENCE; HISTOLOGIC CHARACTERISTICS; INJURIES; MODEL
AB OBJECTIVE: Analyze energy-induced damage to the swine vagina during laparoscopic hysterectomy.
STUDY DESIGN: Laparoscopic colpotomy was performed in swine using ultrasonic, monopolar, and bipolar energy. Specimens (n = 22) from 13 swine were stained with hematoxylin and eosin and Masson's trichrome for energy-related damage. The distal scalpel-cut margin was used as reference. Energy induced damage was assessed by gynecologic and veterinary pathologists blinded to energy source.
RESULTS: Injury was most apparent on Masson's trichrome, demonstrating clear injury demarcation, allowing consistent, quantitative damage measurements. Mean injury was 0 +/- 0 mu M (scalpel, n = 22), 782 +/- 359 mu M (ultrasonic, n = 7), 2016 +/- 1423 mu M (monopolar, n = 8), and 3011 +/- 1239 mu M (bipolar, n = 7). Using scalpel as the reference, all were significant (P < .001).
CONCLUSION: All energy sources demonstrated tissue damage, with ultrasonic showing the least and bipolar the greatest. Further study of tissue damage relative to cuff closure at laparoscopic hysterectomy is warranted.
C1 [Gruber, Daniel D.; Warner, William B.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA.
[Lombardini, Eric D.] Armed Forces Radiobiol Res Inst, Bethesda, MD USA.
[Zahn, Christopher M.; Buller, Jerome L.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD USA.
RP Gruber, DD (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA.
NR 18
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U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD NOV
PY 2011
VL 205
IS 5
AR 494.e1
DI 10.1016/j.ajog.2011.07.009
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 842EB
UT WOS:000296572300040
PM 21924395
ER
PT J
AU Harris, BM
Blatz, PJ
Hinkle, MK
McCall, S
Beckius, ML
Mende, K
Robertson, JL
Griffith, ME
Murray, CK
Hospenthal, DR
AF Harris, Brande M.
Blatz, Peter J.
Hinkle, Mary K.
McCall, Suzanne
Beckius, Miriam L.
Mende, Katrin
Robertson, Janelle L.
Griffith, Matthew E.
Murray, Clinton K.
Hospenthal, Duane R.
TI In Vitro and In Vivo Activity of First Generation Cephalosporins Against
Leptospira
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HAMSTER MODEL; ANTIMICROBIAL AGENTS; SUSCEPTIBILITIES; AZITHROMYCIN;
INTERROGANS; PENICILLIN; EFFICACY; THERAPY
AB Third generation cephalosporins are commonly used in the treatment of leptospirosis. The efficacy of first generation cephalosporins has been less well-studied. Susceptibility testing of 13 Leptospira strains (11 serovars) to cefazolin and cephalexin was conducted using broth microdilution. Median minimal inhibitory concentration (MIC) for cefazolin and cephalexin ranged from <0.016 to 2 mu g/mL (MIC(90) = 0.5 mu g/mL) and from 1 to 8 mu g/mL (MIC(90) = 8 mu g/mL), respectively. Efficacy of cefazolin and cephalexin in an acute lethal hamster model of leptospirosis was studied. Survival rates for cefazolin were 80%, 100%, and 100%, and survival rates for cephalexin were 50%, 80%, and 100% (treated with 5, 25, and 50 mg/kg per day for 5 days, respectively). Each treatment group showed improved survival compared with no treatment (P <0.01), and none of the therapies, regardless of dose, was statistically significantly different than doxycycline. These results support a potential role for first generation cephalosporins as alternative therapies for leptospirosis.
C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA.
Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
Wilford Hall USAF Med Ctr, Dept Med, Lackland AFB, TX USA.
Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
Elgin Hosp, Dept Med, Eglin AFB, FL USA.
RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
RI Valle, Ruben/A-7512-2013
FU Global Emerging Infections Surveillance and Response System (GETS; a
division of the Armed Forces Health Surveillance Center); Infectious
Disease Clinical Research Program (IDCRP), Department of Defense (DoD)
[IDCRP-032]; National Institute of Allergy and Infectious Diseases,
National Institutes of Health (NTH) [Y1-AI-5072]
FX Support for this work was provide by the Global Emerging Infections
Surveillance and Response System (GETS; a division of the Armed Forces
Health Surveillance Center) and the Infectious Disease Clinical Research
Program (IDCRP; protocol IDCRP-032), a Department of Defense (DoD)
program executed through the Uniformed Services University of the Health
Sciences. This project has been funded in whole or part by federal funds
from the National Institute of Allergy and Infectious Diseases, National
Institutes of Health (NTH) under Inter-Agency Agreement Y1-AI-5072.
NR 22
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U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD NOV
PY 2011
VL 85
IS 5
BP 905
EP 908
DI 10.4269/ajtmh.2011.11-0352
PG 4
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 843HC
UT WOS:000296661900021
PM 22049047
ER
PT J
AU Zao, CL
Ward, JA
Tomanek, L
Cooke, A
Berger, R
Armstrong, K
AF Zao, Chih-Ling
Ward, John A.
Tomanek, Lisa
Cooke, Anthony
Berger, Ron
Armstrong, Karyn
TI Virological and serological characterization of SRV-4 infection in
cynomolgus macaques
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID MONKEYS MACACA-FASCICULARIS; NONHUMAN-PRIMATES; RETROVIRUS; TRANSPORT;
ANTIBODY; STRESS
AB The nature of SRV-4 infection in cynomolgus macaques remains unclear to date. Here, we report the monitoring of 24 cynomolgus monkeys that were naturally infected with SRV-4 for virus isolation, proviral load and antibody. The results indicated that the SRV-4 antibody status was statistically correlated to environmental temperature.
C1 [Zao, Chih-Ling; Tomanek, Lisa; Cooke, Anthony; Berger, Ron] VRL Labs, San Antonio, TX 78229 USA.
[Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Armstrong, Karyn] Covance Res Prod, Alice, TX 78333 USA.
RP Zao, CL (reprint author), VRL Labs, 7540 Louis Pasteur,Suite 250, San Antonio, TX 78229 USA.
EM chih-ling.zao@vrl.net
FU VRL Laboratories; Covance Research Products
FX The opinions or assertions herein are the private views of the authors
and are not to be constructed as reflecting the views of the Department
of the Army or the Department of Defense. This work was funded by VRL
Laboratories and Covance Research Products.
NR 15
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U1 0
U2 5
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
J9 ARCH VIROL
JI Arch. Virol.
PD NOV
PY 2011
VL 156
IS 11
BP 2053
EP 2056
DI 10.1007/s00705-011-1068-y
PG 4
WC Virology
SC Virology
GA 841JZ
UT WOS:000296509900016
PM 21779910
ER
PT J
AU Keiser, PB
Nelson, MR
AF Keiser, Paul B.
Nelson, Michael R.
TI Baseline differences explain the apparent benefits of combining
oxymetazoline with intranasal corticosteroids
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Letter
C1 [Keiser, Paul B.; Nelson, Michael R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Keiser, PB (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA.
EM paul.keiser@us.army.mil
NR 2
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD NOV
PY 2011
VL 128
IS 5
BP 1132
EP 1132
DI 10.1016/j.jaci.2011.07.016
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA 842FJ
UT WOS:000296578200040
PM 21820715
ER
PT J
AU Moran, DS
Evans, RK
Arbel, Y
Hadid, A
Laor, A
Fuks, Y
AF Moran, Daniel S.
Evans, Rachel K.
Arbel, Yael
Hadid, Amir
Laor, Arie
Fuks, Yael
TI PREDICTION MODEL FOR ATTRITION FROM A COMBAT UNIT TRAINING PROGRAM
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE military recruits; basic training; risk factors; soldier dropout
ID PHYSICAL-FITNESS; BODY-COMPOSITION; FOOD FREQUENCY; RECRUITS; SUCCESS
AB Moran, DS, Evans, RK, Arbel, Y, Hadid, A, Laor, A, and Fuks, Y. Prediction model for attrition from a combat unit training program. J Strength Cond Res 25(11): 2963-2970, 2011-The purpose of this study was to develop a prediction model for the attrition rate of soldiers from an 8-month advanced military training program based on physical and psychological factors. Two groups of 59 and 61 healthy, fit young men (18.7 +/- 0.7 years) entering a rigorous combat unit training program in the Israeli Defense Forces were recruited to participate in this study. Data on anthropometrics, nutrition, blood measures (chemical and hematological), fitness, and bone quality were collected on the induction day. Psychological questionnaires were completed at 3 time points: baseline-upon entry to basic training (BT), after 2 months, and after 4 months (completion of BT). The data of the 2 groups were pooled together for the analysis and to construct a new prediction model for attrition (Patt) as follows: Patt = 11.20 - 0.87Est(Com4) - 0.72Sc - 0.23%BF; where Est(Com4) is commander appreciation as perceived by the soldier after 4-month BT, Sc is a self-confidence grade, and %BF is the % body fat. The new suggested model successfully predicted 75.3% of subject attrition in the combat unit. We therefore concluded that Special Forces recruits with relatively low body fat percentage (% BF), low self-esteem, and who feel unappreciated by their commander are at a higher dropout risk from a rigorous combat training program.
C1 [Moran, Daniel S.; Arbel, Yael; Hadid, Amir; Laor, Arie; Fuks, Yael] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
[Moran, Daniel S.] Ariel Univ, Ctr Samaria, Sch Hlth Sci, Ariel, Israel.
[Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
EM dmoran@sheba.health.gov.il
FU MRMC [W911QY-08-P-0286]
FX The study was supported in part by a contract from the MRMC (No.
W911QY-08-P-0286). The opinions or the assertions contained here are the
private views of the authors and are not to be construed as official or
as reflecting the views of the US Army, the IDF or the Department of
Defense. The results of this study do not constitute endorsement of the
product by the authors or the National Strength and Conditioning
Association. The authors have no conflict of interest to disclose.
NR 21
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U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD NOV
PY 2011
VL 25
IS 11
BP 2963
EP 2970
DI 10.1519/JSC.0b013e318212dcf7
PG 8
WC Sport Sciences
SC Sport Sciences
GA 841KM
UT WOS:000296511200004
PM 21988903
ER
PT J
AU Holt, DB
Delaney, RR
Uyehara, CFT
AF Holt, Danielle B.
Delaney, Richard R.
Uyehara, Catherine F. T.
TI Effects of Combination Dobutamine and Vasopressin Therapy on
Microcirculatory Blood Flow in a Porcine Model of Severe Endotoxic Shock
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE endotoxic shock; vasopressin; dobutamine; microcirculation
ID CRITICALLY ILL PATIENTS; SEPTIC SHOCK; SEVERE SEPSIS; OXYGEN-TRANSPORT;
HEMODYNAMICS; TERLIPRESSIN; MECHANISMS; INFUSION
AB Background. Dobutamine (DB) has been recommended in combination with vasopressor therapy in septic shock, given its reported ability to improve mesenteric and microcirculatory perfusion. Vasopressin (VP) is typically reserved as a second-line agent due to the concern of ischemia. The purpose of our study was to determine whether combination DB and VP therapy improved microcirculatory blood flow in severe endotoxic shock.
Methods. Septic shock was induced in 20 anesthetized piglets with injection of E. coli endotoxin. DB (10 mu g/kg/min, n [ 5) and VP (0.04 units/min, n = 10) were administered alone and in combination (n = 15). Measurements were compared at baseline, following endotoxin administration, and following treatment. Microcirculatory blood flow was determined via the injection of colored microspheres.
Results. VP completely reversed endotoxin-mediated hypotension with a mean arterial pressure (MAP) of 85 +/- 4.5mm Hg, which was not significantly altered with the addition of DB (77 +/- 4.9mm Hg). Endotoxin uniformly depressed cardiac output (CO) from baseline (227 +/- 10.7 versus 174 +/- 12.4mL/min/kg) despite treatment with VP alone or in combination with DB. The addition of DB did not improve the CO in this severe septic shock model. VP was found to shunt microcirculatory flow from the skin and GI tract to vital organs such as the brain, liver, and kidneys, which was not altered with the addition of DB.
Conclusions. Results indicate that DB is ineffective in increasing CO or improving mesenteric blood flow when used with physiologic replacement doses of VP. In combination, DB is unable to overcome the blood flow distribution achieved with VP administration alone in severe endotoxic shock. Published by Elsevier Inc.
C1 [Holt, Danielle B.; Delaney, Richard R.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Uyehara, CFT (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Tripler, HI 96859 USA.
EM catherine.uyehara@amedd.army.mil
FU U.S. Army Medical Research and Material Command [DAMD 17-03-1-0072]
FX The authors acknowledge support for this project by the U.S. Army
Medical Research and Material Command Congressionally Directed Medical
Research Program grant no. DAMD 17-03-1-0072. The views expressed in
this paper are those of the authors and do not reflect the official
policy or position of the Department of the Army, Department of Defense,
or the U. S. Government.
NR 27
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PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2011
VL 171
IS 1
BP 191
EP 198
DI 10.1016/j.jss.2009.11.739
PG 8
WC Surgery
SC Surgery
GA 839LS
UT WOS:000296368000049
PM 20338585
ER
PT J
AU Crum-Cianflone, NF
Shadyab, AH
Weintrob, A
Hospenthal, DR
Lalani, T
Collins, G
Mask, A
Mende, K
Brodine, SK
Agan, BK
AF Crum-Cianflone, Nancy F.
Shadyab, Aladdin H.
Weintrob, Amy
Hospenthal, Duane R.
Lalani, Tahaniyat
Collins, Gary
Mask, Alona
Mende, Katrin
Brodine, Stephanie K.
Agan, Brian K.
CA Infect Dis Clinical Res Program HI
TI Association of Methicillin-Resistant Staphylococcus aureus (MRSA)
Colonization With High-Risk Sexual Behaviors in Persons Infected With
Human Immunodeficiency Virus (HIV)
SO MEDICINE
LA English
DT Article
ID SOFT-TISSUE INFECTION; NASAL CARRIAGE; DRUG-USERS; PREVALENCE; SKIN;
MEN; OUTPATIENTS; EMERGENCE; POPULATIONS; USA300
AB Methicillin-resistant Staphylococcus aureus (MRSA) infections are an important cause of morbidity, especially among human immunodeficiency virus (HIV)-infected persons. Since an increasing number of MRSA skin and soft tissue infections involve the perigenital areas, some have suggested that these infections may be sexually transmitted. We performed a cross-sectional study among HIV-infected adults from 4 geographically diverse United States military HIV clinics to determine the prevalence of and the factors (including sexual practices) associated with MRSA colonization. Swabs were collected from the nares, throat, axillae, groin area, and perirectal area for S. aureus colonization. Data on sociodemographic characteristics, medical conditions, and sexual history were collected. Multivariate logistic regression models evaluated factors associated with carriage. We studied 550 HIV-infected adults with a median age of 42 years; 93% were male; and race/ethnicity was white for 46%, African American for 35%, and other for 19%. Median CD4 count was 529 cells/mm(3), 11% had a history of a MRSA infection, and 21% had a sexually transmitted infection within the last year, including 8% with syphilis. One hundred eighty (33%) were colonized with S. aureus and 22 (4%) with MRSA. The most common location for carriage was the nares, followed by the perigenital area (groin or perirectal area). Factors associated with MRSA carriage in the multivariate analyses included a sexually transmitted infection in the last year (odds ratio [OR], 4.2; p < 0.01), history of MRSA infection (OR, 9.4; p < 0.01), and African American compared with white race/ethnicity (OR, 3.5; p = 0.01). In separate multivariate models, syphilis, nongonococcal urethritis, and public bath use were also associated with MRSA carriage (all p < 0.01). In conclusion, a history of recent sexually transmitted infections, including syphilis and urethritis, was associated with MRSA carriage. These data suggest that high-risk sexual activities may play a role in MRSA transmission. (Medicine 2011;90: 379Y389)
C1 [Crum-Cianflone, Nancy F.] USN, Clin Invest Dept KCA, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92134 USA.
[Crum-Cianflone, Nancy F.; Weintrob, Amy; Hospenthal, Duane R.; Lalani, Tahaniyat; Collins, Gary; Mask, Alona; Mende, Katrin; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Crum-Cianflone, Nancy F.; Shadyab, Aladdin H.; Brodine, Stephanie K.] San Diego State Univ, San Diego, CA 92182 USA.
[Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA.
[Hospenthal, Duane R.; Mende, Katrin] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA.
[Lalani, Tahaniyat] USN, Infect Dis Clin, Med Ctr Portsmouth, Portsmouth, VA USA.
[Collins, Gary] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
RP Crum-Cianflone, NF (reprint author), USN, Clin Invest Dept KCA, San Diego Med Ctr, Infect Dis Clin, 34800 Bob Wilson Dr,Suite 5, San Diego, CA 92134 USA.
EM nancy.crum@med.navy.mil
RI Valle, Ruben/A-7512-2013;
OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-003];
Department of Defense through the Uniformed Services University of the
Health Sciences; Global Emerging Infections Surveillance and Response
System (GEIS), a division of the Armed Forces Health Surveillance
Center; National Institute of Allergy and Infectious Diseases (NIAID),
National Institutes of Health (NIH) [Y1-AI-5072]; NIAID/NIH
[HHSN272200700055C]
FX Support for this work (IDCRP-003) was provided by the Infectious Disease
Clinical Research Program (IDCRP), a Department of Defense program
executed through the Uniformed Services University of the Health
Sciences and by the Global Emerging Infections Surveillance and Response
System (GEIS), a division of the Armed Forces Health Surveillance
Center. This project has been funded in whole, or in part, with federal
funds from the National Institute of Allergy and Infectious Diseases
(NIAID), National Institutes of Health (NIH), under Inter-Agency
Agreement Y1-AI-5072.; The USA type reference strains used for
pulse-field gel electrophoresis (PFGE) analysis were obtained through
the Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA)
program supported under NIAID/NIH Contract No. HHSN272200700055C.
NR 49
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U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0025-7974
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2011
VL 90
IS 6
BP 379
EP 389
DI 10.1097/MD.0b013e318238dc2c
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA 844CB
UT WOS:000296724100003
PM 22033452
ER
PT J
AU Berkowitz, JF
Sallee, JB
AF Berkowitz, Jacob F.
Sallee, James Barrett
TI Investigating Problematic Hydric Soils using Hydrology, IRIS Tubes,
Chemistry, and the Hydric Soils Technical Standard
SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL
LA English
DT Article
ID USA
AB Resource professionals rely on soil morphology to make determinations of hydric soil status. Characteristic morphologies led to the development of field indicators for hydric soil identification and delineation. This study examined soils not meeting approved field indicators. These included high-chroma sandy soils, dark sandy soils, and marl soils located in Michigan. All soils displayed high water tables within 25 cm (10 in) of the surface for a minimum of 14 consecutive days. Indicator of reduction in soils (IRIS) tube data confirmed reducing conditions in wetland sites, with average Fe removal of 74%; only 4.8% removal was observed in uplands. Ten of 11 soils examined met the hydric soil technical standard (HSTS). Results indicate that two additional field indicators (S7-Dark surface and F10-Marl) should be approved in the region. Soil chemical data examined the development of hydric soil morphologies. Laboratory incubations monitored the formation of low-chroma colors with artificial C substrate in high-chroma sands. This work expands the range of accepted field indicators and provides a case study for applying the HSTS to problematic soil situations.
C1 [Berkowitz, Jacob F.] USA, Wetlands & Coastal Ecol Branch, Environm Lab, Engineer Res & Dev Ctr,Corps Engineers,CEERD EE W, Vicksburg, MS 39180 USA.
[Sallee, James Barrett] Michigan Dep Environm Qual, Div Water Resources, Jackson, MI 49201 USA.
RP Berkowitz, JF (reprint author), USA, Wetlands & Coastal Ecol Branch, Environm Lab, Engineer Res & Dev Ctr,Corps Engineers,CEERD EE W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Jacob.F.Berkowitz@usace.army.mil
FU U.S. Army Corps of Engineers-Detroit District
FX Donald Reinke, Chad Fizzell, Mike Kost, Brad Slaughter, Josh Cohen,
William Bowman, Steve Tardy, Matt Bromley, John Werlein, Dwight Jerome,
Nathan Schulz, Jeffrey Fritsma, Sue Bright, Aaron Damrill, Becky Otto,
and Edward Arthur provided support in identification and sampling of
field sites. Special thanks to Sabrina Miller for valuable input.
Funding provided by the U.S. Army Corps of Engineers-Detroit District.
NR 38
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U1 4
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PU SOIL SCI SOC AMER
PI MADISON
PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA
SN 0361-5995
J9 SOIL SCI SOC AM J
JI Soil Sci. Soc. Am. J.
PD NOV
PY 2011
VL 75
IS 6
BP 2379
EP 2385
DI 10.2136/sssaj2011.0040
PG 7
WC Soil Science
SC Agriculture
GA 841ZK
UT WOS:000296553600037
ER
PT J
AU Dreicer, R
Bajorin, DF
McLeod, DG
Petrylak, DP
Moul, JW
AF Dreicer, Robert
Bajorin, Dean F.
McLeod, David G.
Petrylak, Daniel P.
Moul, Judd W.
TI New Data, New Paradigms for Treating Prostate Cancer Patients-VI: Novel
Hormonal Therapy Approaches
SO UROLOGY
LA English
DT Article
ID I CLINICAL-TRIAL; ABIRATERONE ACETATE; DIHYDROTESTOSTERONE LEVELS; SERUM
TESTOSTERONE; AGONIST THERAPY; PHASE-III; CASTRATION; CYP17;
ANTIANDROGEN; ORCHIECTOMY
AB Until the 1980s, testosterone suppression for men with advanced prostate cancer was managed surgically, with bilateral orchiectomy, or medically, with diethylstilbestrol, a drug that was associated with a problematic side effect profile. Beginning in the mid-1980s, the U.S. Food and Drug Administration approved the first luteinizing hormone-releasing hormone agonists, which proved effective for suppressing circulating testosterone levels and led to a significant shift away from surgical castration to medical management during the past 25 years. The luteinizing hormone-releasing hormone agonists resulted in a periodic return of noncastrate testosterone levels once the receptor desensitization attenuated and the effect of androgen agonism resumed. Therefore, the introduction of an androgen receptor antagonist (gonadotropin-releasing hormone antagonist) appeared, conceptually at least, to be a preferable alternative. The first such agent, degarelix, has proved to provide rapid testosterone suppression without the initial testosterone surge associated with luteinizing hormone-releasing hormone agonists. Other new agents in early development include a selective and irreversible inhibitor of CYP17, abiraterone, which has shown success in patients with castration-resistant metastatic prostate cancer, and MDV3100, a novel small molecule that acts as an oral nonsteroidal antiandrogen agent. In sum, these latest agents might lead to a paradigm shift in the treatment of patients with advanced prostate cancer; however, additional studies are required to clarify the many questions that remain regarding the optimal use and sequence of these agents. UROLOGY 78: S494-S498, 2011. (C) 2011 Published by Elsevier Inc.
C1 [Petrylak, Daniel P.] Columbia Univ, Dept Med, Div Med Oncol, Herbert Irving Canc Ctr,Med Ctr, New York, NY 10032 USA.
Cleveland Clin, Dept Solid Tumor Oncol, Taussig Canc Inst, Cleveland, OH 44106 USA.
Cleveland Clin, Lerner Coll Med, Dept Med, Cleveland, OH 44106 USA.
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA.
Mem Sloan Kettering Canc Ctr, Div Solid Tumor Oncol, Genitourinary Oncol Serv, New York, NY 10021 USA.
US Army Ret, Ctr Prostat Dis Res, Div Urol Oncol, Walter Reed Army Med Ctr, Washington, DC USA.
Herbert Irving Canc Ctr, Prostate Canc Program, Dept Med, Div Med Oncol, New York, NY USA.
Duke Univ, Med Ctr, Dept Surg, Div Urol Surg, Durham, NC 27710 USA.
RP Petrylak, DP (reprint author), Columbia Univ, Dept Med, Div Med Oncol, Herbert Irving Canc Ctr,Med Ctr, Atchley Pavil,Room 908,161 Ft Washington Ave, New York, NY 10032 USA.
EM dpp5@columbia.edu
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U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
J9 UROLOGY
JI Urology
PD NOV
PY 2011
VL 78
IS 5
SU S
BP S494
EP S498
DI 10.1016/j.urology.2011.06.058
PG 5
WC Urology & Nephrology
SC Urology & Nephrology
GA 844QB
UT WOS:000296761300006
PM 22054921
ER
PT J
AU Cohen, SP
Strassels, SA
Kurihara, C
Lesnick, IK
Hanling, SR
Griffith, SR
Buckenmaier, CC
Nguyen, C
AF Cohen, Steven P.
Strassels, Scott A.
Kurihara, Connie
Lesnick, Ivan K.
Hanling, Steven R.
Griffith, Scott R.
Buckenmaier, Chester C., III
Nguyen, Conner
TI Does Sensory Stimulation Threshold Affect Lumbar Facet Radiofrequency
Denervation Outcomes? A Prospective Clinical Correlational Study
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID LOW-BACK-PAIN; ZYGAPOPHYSIAL JOINT PAIN; DOUBLE-BLIND; MEDIAL BRANCH;
NERVE BLOCK; NEUROTOMY; EFFICACY; TRIAL; MANAGEMENT; MULTICENTER
AB BACKGROUND: Radiofrequency facet denervation is one of the most frequently performed procedures for chronic low back pain. Although sensory stimulation is generally used as a surrogate measure to denote sufficient proximity of the electrode to the nerve, no study has examined whether stimulation threshold influences outcome.
METHODS: We prospectively recorded data in 61 consecutive patients undergoing lumbar facet radiofrequency denervation who experienced significant pain relief after medial branch blocks. For each nerve lesioned, multiple attempts were made to maximize sensory stimulation threshold (SST). Mean SST was calculated on the basis of the lowest stimulation perceived at 0.1-V increments for each medial branch. A positive outcome was defined as a >= 50% reduction in back pain coupled with a positive satisfaction score lasting >= 3 months. The relationship between mean SST and denervation outcomes was evaluated via a receiver's operating characteristic (ROC) curve, and stratifying outcomes on the basis of various cutoff values.
RESULTS: No correlation was noted between mean SST and pain relief at rest (Pearson's r = -0.01, 95% confidence interval [CI]: -0.24 to 0.23, P = 0.97), with activity (r = -0.17, 95% CI: -0.40 to 0.07, P = 0.20), or a successful outcome. No optimal SST could be identified.
CONCLUSIONS: There is no significant relationship between mean SST during lumbar facet radiofrequency denervation and treatment outcome, which may be due to differences in general sensory perception. Because stimulation threshold was optimized for each patient, these data cannot be interpreted to suggest that sensory testing should not be performed, or that high sensory stimulation thresholds obtained on the first attempt should be deemed acceptable. (Anesth Analg 2011; 113: 1233-41)
C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA.
[Kurihara, Connie; Griffith, Scott R.; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Dept Surg, Pain Management Div, Anesthesia Serv, Washington, DC 20307 USA.
[Lesnick, Ivan K.; Hanling, Steven R.] USN, Dept Anesthesiol, Med Ctr San Diego, San Diego, CA 92152 USA.
[Griffith, Scott R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Buckenmaier, Chester C., III] Def & Vet Pain Management Initiat, Washington, DC USA.
[Nguyen, Conner] Landstuhl Reg Med Ctr, Dept Surg, Phys Med & Rehabil Serv, Landstuhl, Germany.
RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA.
EM scohen40@jhmi.edu
FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; U.S.
Army; Defense and Veterans Pain Management Initiative, Washington, DC
FX Funded in part by a Congressional grant from the John P. Murtha
Neuroscience and Pain Institute, Johnstown, PA; the U.S. Army; and the
Defense and Veterans Pain Management Initiative, Washington, DC.
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-2999
J9 ANESTH ANALG
JI Anesth. Analg.
PD NOV
PY 2011
VL 113
IS 5
BP 1233
EP 1241
DI 10.1213/ANE.0b013e31822dd379
PG 9
WC Anesthesiology
SC Anesthesiology
GA 837VW
UT WOS:000296236200043
PM 21918166
ER
PT J
AU Lafferty, BJ
Ginder-Vogel, M
Sparks, DL
AF Lafferty, Brandon J.
Ginder-Vogel, Matthew
Sparks, Donald L.
TI Arsenite Oxidation by a Poorly-Crystalline Manganese Oxide. 3. Arsenic
and Manganese Desorption
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID X-RAY-DIFFRACTION; NA-RICH BIRNESSITE; HEXAGONAL-BIRNESSITE; ABSORPTION
SPECTROSCOPY; SYNTHETIC BIRNESSITE; NATURAL SPECIATION; IRON-OXIDES;
MN-OXIDES; ADSORPTION; SORPTION
AB Arsenic (As) mobility in the environment is greatly affected by its oxidation state and the degree to which it is sorbed on metal oxide surfaces. Manganese oxides (Mn oxides) have the ability to decrease overall As mobility both by oxidizing toxic arsenite (As) to less toxic arsenate (As(V)), and by sorbing As. However, the effect of competing ions on the mobility of As sorbed on Mn-oxide surfaces is not well understood. In this study, desorption of As(V) and As(III) from a poorly crystalline phyllomanganate (delta-MnO(2)) by two environmentally significant ions is investigated using a stirred-flow technique and X-ray absorption spectroscopy (XAS). As(III) is not observed in solution after desorption under any conditions used in this study, agreeing with previous studies showing As sorbed on Mn-oxides exists only as As(V). However, some As(V) is desorbed from the delta-MnO(2) surface under all conditions studied, while neither desorptive used in this study completely removes As(V) from the delta-MnO(2) surface.
C1 [Lafferty, Brandon J.; Ginder-Vogel, Matthew; Sparks, Donald L.] Univ Delaware, Delaware Environm Inst, Dept Plant & Soil Sci, Newark, DE 19716 USA.
RP Lafferty, BJ (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM blafferty@gmail.com
FU University of Delaware; United States Department of Agriculture
[2005-35107-16105]; National Science Foundation [EAR-0544246]; Delaware
National Science Foundation EPSCoR [EPS-0447610]; U.S. Department of
Energy, Office of Science, Office of Basic Energy Sciences
[DE-AC02-98CH10886]; Donald L. and Joy G. Sparks Graduate Fellowship in
Soil Science
FX The authors thank Gerald Hendricks and Caroline Golt for laboratory
assistance. B.L. is grateful for funding provided by a University of
Delaware graduate fellowship and the Donald L. and Joy G. Sparks
Graduate Fellowship in Soil Science. This research was funded by United
States Department of Agriculture Grant 2005-35107-16105, National
Science Foundation Grant EAR-0544246, and Delaware National Science
Foundation EPSCoR Grant EPS-0447610. Use of the National Synchrotron
Light Source, Brookhaven National Laboratory, was supported by the U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract No. DE-AC02-98CH10886.
NR 42
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U1 9
U2 77
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 1
PY 2011
VL 45
IS 21
BP 9218
EP 9223
DI 10.1021/es201281u
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 837OI
UT WOS:000296212700017
PM 21950706
ER
PT J
AU Koh, G
Wakeley, LD
AF Koh, Gary
Wakeley, Lillian D.
TI Impact of Gypsum on Electromagnetic Properties of Desert Soils
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Afghanistan; gypsum; Iraq; soil electromagnetic (EM) properties; soil
mineralogy
ID MICROWAVE DIELECTRIC BEHAVIOR; WET SOIL; MODELS
AB Radar remote sensing of soil requires an understanding about the electromagnetic properties of soils. Propagation velocities and attenuation rates at ground-penetrating radar frequencies (0.25-4 GHz) were measured as a function of soil moisture content for soils from Iraq and Afghanistan. Soil samples in the study include two with and two without gypsum (CaSO(4)center dot 2H(2)O) as a major mineral component. When measured at 100 degrees C, volumetric moisture content of gypsum-rich soils ranged from 12% to 24%. In addition to the high moisture content, the propagation velocities were higher than expected, and attenuation rates were lower than expected for soils with moisture contents in this high range. The apparently anomalous relationship between high moisture content and low attenuation rate is explained by the presence and characteristics of gypsum in the soil. Radar signals are not affected by the chemically bound water molecules in gypsum which dehydrates at 100 degrees C. These results show that soil mineralogy is critically important to the interpretation of dielectric properties.
C1 [Koh, Gary] USA, Cold Reg Res & Engn Lab, Engn Res Dev Ctr, Hanover, NH 03755 USA.
[Wakeley, Lillian D.] USA, Engn Res Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Koh, G (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA.
EM yeohoon.g.koh@usace.army.mil; lillian.d.wakeley@usace.army.mil
FU U.S. Army Engineer Research and Development Center
FX This work was supported by the U.S. Army Engineer Research and
Development Center Geo-Environmental Tactical Sensor Program.
NR 11
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U1 0
U2 10
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD NOV
PY 2011
VL 8
IS 6
BP 1051
EP 1054
DI 10.1109/LGRS.2011.2154297
PG 4
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 840SQ
UT WOS:000296462000009
ER
PT J
AU Gurram, P
Kwon, H
AF Gurram, Prudhvi
Kwon, Heesung
TI Support-Vector-Based Hyperspectral Anomaly Detection Using Optimized
Kernel Parameters
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Anomaly detection; kernel parameter optimization; support vector (SV)
data description (SVDD)
ID IMAGERY
AB In this letter, a method to optimally determine the kernel bandwidth of the Gaussian radial basis function (RBF) kernel for support vector (SV)-based hyperspectral anomaly detection is presented. In this method, the support of a local background distribution is first nonparametrically learned by a technique called SV data description (SVDD). The SVDD optimally models an enclosing hypersphere around the local background data in a high-dimensional feature space associated with the Gaussian RBF kernel. Any test pixel that lies outside this hypersphere surrounding the local background is considered an anomaly and, hence, a possible target pixel. Considerable improvement in detection performance due to kernel parameter optimization can be seen in the simulation results when the algorithm is applied to hyperspectral images.
C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Adelphi, MD 20783 USA.
RP Gurram, P (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM pkgurram@gmail.com; heesung.kwon@us.army.mil
NR 10
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U1 3
U2 21
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD NOV
PY 2011
VL 8
IS 6
BP 1060
EP 1064
DI 10.1109/LGRS.2011.2155030
PG 5
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 840SQ
UT WOS:000296462000011
ER
PT J
AU Arumugam, TU
Takeo, S
Yamasaki, T
Thonkukiatkul, A
Miura, K
Otsuki, H
Zhou, H
Long, CA
Sattabongkot, J
Thompson, J
Wilson, DW
Beeson, JG
Healer, J
Crabb, BS
Cowman, AF
Torii, M
Tsuboi, T
AF Arumugam, Thangavelu U.
Takeo, Satoru
Yamasaki, Tsutomu
Thonkukiatkul, Amporn
Miura, Kazutoyo
Otsuki, Hitoshi
Zhou, Hong
Long, Carole A.
Sattabongkot, Jetsumon
Thompson, Jennifer
Wilson, Danny W.
Beeson, James G.
Healer, Julie
Crabb, Brendan S.
Cowman, Alan F.
Torii, Motomi
Tsuboi, Takafumi
TI Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein,
as a Novel Blood-Stage Vaccine Candidate Antigen
SO INFECTION AND IMMUNITY
LA English
DT Article
ID GROWTH-INHIBITORY ANTIBODIES; ANCHORED MEMBRANE-PROTEINS; MALARIA
PARASITE; HUMAN ERYTHROCYTES; INVASION PATHWAYS; HUMAN-POPULATIONS;
RECEPTOR; BINDING; ERADICATION; RON2
AB One of the solutions for reducing the global mortality and morbidity due to malaria is multivalent vaccines comprising antigens of several life cycle stages of the malarial parasite. Hence, there is a need for supplementing the current set of malaria vaccine candidate antigens. Here, we aimed to characterize glycosylphosphatidylinositol (GPI)-anchored micronemal antigen (GAMA) encoded by the PF08_0008 gene in Plasmodium falciparum. Antibodies were raised against recombinant GAMA synthesized by using a wheat germ cell-free system. Immunoelectron microscopy demonstrated for the first time that GAMA is a microneme protein of the merozoite. Erythrocyte binding assays revealed that GAMA possesses an erythrocyte binding epitope in the C-terminal region and it binds a nonsialylated protein receptor on human erythrocytes. Growth inhibition assays revealed that anti-GAMA antibodies can inhibit P. falciparum invasion in a dose-dependent manner and GAMA plays a role in the sialic acid (SA)-independent invasion pathway. Anti-GAMA antibodies in combination with anti-erythrocyte binding antigen 175 exhibited a significantly higher level of invasion inhibition, supporting the rationale that targeting of both SA-dependent and SA-independent ligands/pathways is better than targeting either of them alone. Human sera collected from areas of malaria endemicity in Mali and Thailand recognized GAMA. Since GAMA in P. falciparum is refractory to gene knockout attempts, it is essential to parasite invasion. Overall, our study indicates that GAMA is a novel blood-stage vaccine candidate antigen.
C1 [Arumugam, Thangavelu U.; Takeo, Satoru; Yamasaki, Tsutomu; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan.
[Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan.
[Thonkukiatkul, Amporn] Burapha Univ, Dept Biol, Fac Sci, Chon Buri 20131, Thailand.
[Miura, Kazutoyo; Zhou, Hong; Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA.
[Otsuki, Hitoshi] Tottori Univ, Div Med Zool, Fac Med, Tottori 6838503, Japan.
[Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Thompson, Jennifer; Wilson, Danny W.; Healer, Julie; Cowman, Alan F.] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia.
[Beeson, James G.; Crabb, Brendan S.] Burnet Inst, Melbourne, Vic 3004, Australia.
[Torii, Motomi] Ehime Univ, Dept Mol Parasitol, Grad Sch Med, Toon, Ehime 7910295, Japan.
[Torii, Motomi; Tsuboi, Takafumi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan.
RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, 3 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan.
EM tsuboi@ccr.ehime-u.ac.jp
RI Cowman, Alan/C-7642-2013; Crabb, Brendan/F-5287-2013
OI Cowman, Alan/0000-0001-5145-9004;
FU Bill and Melinda Gates Foundation; Ministry of Education, Culture,
Sports, Science and Technology [21249028, 21022034, 23406007, 23117008];
Ministry of Health, Labor, and Welfare, Japan
[H21-Chikyukibo-ippan-005]; National Institute of Allergy and Infectious
Diseases/NIH; PATH/Malaria Vaccine Initiative
FX This research was supported in part by grants from The Bill and Melinda
Gates Foundation, from the Ministry of Education, Culture, Sports,
Science and Technology (21249028, 21022034, 23406007, and 23117008), and
from the Ministry of Health, Labor, and Welfare, Japan
(H21-Chikyukibo-ippan-005). This study was supported in part by the
intramural program of the National Institute of Allergy and Infectious
Diseases/NIH, and the GIA Reference Center is supported by the
PATH/Malaria Vaccine Initiative.
NR 38
TC 28
Z9 28
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD NOV
PY 2011
VL 79
IS 11
BP 4523
EP 4532
DI 10.1128/IAI.05412-11
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 839GB
UT WOS:000296352400023
PM 21896773
ER
PT J
AU Kim, S
Tsao, H
Kang, YQ
Young, DA
Sen, M
Wenke, JC
Yang, YZ
AF Kim, Sungwoo
Tsao, Helen
Kang, Yunqing
Young, Daniel A.
Sen, Milan
Wenke, Joseph C.
Yang, Yunzhi
TI In vitro evaluation of an injectable chitosan gel for sustained local
delivery of BMP-2 for osteoblastic differentiation
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE injectable gel; chitosan; beta-glycerophosphate (beta-GP); BMP-2;
biocompatibility; release profile; osteoblastic differentiation;
W-20-17; HEPM
ID BONE MORPHOGENETIC PROTEIN-2; MARROW STROMAL CELLS; DRUG-DELIVERY;
BETA-GLYCEROPHOSPHATE; PHOSPHATE SOLUTIONS; THERMOSENSITIVE CHITOSAN;
BIOMEDICAL APPLICATIONS; STEM-CELLS; HYDROGEL; SYSTEM
AB We investigated the effect of sustained release of bone morphogenetic protein-2 (BMP-2) from an injectable chitosan gel on osteoblastic differentiation in vitro. We first characterized the release profile of BMP-2 from the gels, and then examined the cellular responses of preosteoblast mouse stromal cells (W-20-17) and human embryonic palatal mesenchymal (HEPM) cells to BMP-2. The release profiles of different concentrations of BMP-2 exhibited sustained releases (41% for 2 ng/mL and 48% for 20 ng/mL, respectively) from the chitosan gels over a three-week period. Both cell types cultured in the chitosan gels were viable and significantly proliferated for 3 days (p < 0.05). Chitosan gels loaded with BMP-2 enhanced ALP activity of W-20-17 by 3.6-fold, and increased calcium mineral deposition of HEPM by 2.8-fold at 14 days of incubation, compared to control groups initially containing the same amount of BMP-2. In addition, schitosan gels loaded with BMP-2 exhibited significantly greater osteocalcin synthesis of W-20-17 at seven days, and of HEPM at both 7 and 14 days compared with the control groups (p<0.05). This study suggests that the enhanced effects of BMP-2 released from chitosan gels on cell differentiation and mineralization are species and cell type dependent. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 99B: 380-390, 2011.
C1 [Kim, Sungwoo; Tsao, Helen; Kang, Yunqing; Young, Daniel A.; Yang, Yunzhi] Univ Texas Hlth Sci Ctr Houston, Dept Restorat Dent & Biomat, Houston, TX 77030 USA.
[Sen, Milan] Univ Texas Hlth Sci Ctr Houston, Dept Orthoped Surg, Houston, TX 77030 USA.
[Wenke, Joseph C.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, San Antonio, TX USA.
RP Yang, YZ (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Restorat Dent & Biomat, Houston, TX 77030 USA.
EM yunzhi.yang@uth.tmc.edu
OI Young, Daniel/0000-0003-1214-9577
FU March of Dimes Birth Defect Foundation; Airlift Research Foundation;
Wallace H. Coulter Foundation [DOD W81XWH-10-1-0966, W81XWH-10-2-0010];
NIH [R01AR057837, R01DE021468]
FX Contract grant sponsor: March of Dimes Birth Defect Foundation; Contract
grant sponsor: Airlift Research Foundation, Wallace H. Coulter
Foundation; contract grant numbers: DOD W81XWH-10-1-0966,
W81XWH-10-2-0010; Contract grant sponsor: NIH; contract grant numbers:
R01AR057837, R01DE021468
NR 49
TC 15
Z9 17
U1 0
U2 21
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1552-4973
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD NOV
PY 2011
VL 99B
IS 2
BP 380
EP 390
DI 10.1002/jbm.b.31909
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 837WQ
UT WOS:000296240200019
PM 21905214
ER
PT J
AU Armistead-Jehle, P
Hansen, CL
AF Armistead-Jehle, Patrick
Hansen, Christopher L.
TI Comparison of the Repeatable Battery for the Assessment of
Neuropsychological Status Effort Index and Stand-Alone Symptom Validity
Tests in a Military Sample
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE Neuropsychology; Military; Symptom validity testing
ID MALINGERED NEUROCOGNITIVE DYSFUNCTION; MEMORY IMPAIRMENT; CLASSIFICATION
ACCURACY; GERIATRIC SAMPLE; BRAIN-INJURY; STATUS RBANS; DIGIT SPAN;
PERFORMANCE; CONCUSSION; CLAIMANTS
AB The current study sought to report the base rates of Symptom Validity Test (SVT) failure in an active duty military sample as well as to compare the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Effort Index (EI) to stand-alone measures of symptom validity. SVT failure varied from previous studies and even among different subgroups in the current sample, ranging from 8% to 30%. The RBANS EI demonstrated modest sensitivity in the detection of suboptimal effort when compared with stand-alone SVTs. Although the index appears to add some utility to the detection of suboptimal effort, sole use of the EI as a measure of symptom validity could conceivably result in an unnecessarily high rate of false negatives.
C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA.
[Hansen, Christopher L.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20307 USA.
RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA.
EM patrick.jehle@amedd.army.mil
NR 40
TC 32
Z9 32
U1 2
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD NOV
PY 2011
VL 26
IS 7
BP 592
EP 601
DI 10.1093/arclin/acr049
PG 10
WC Psychology, Clinical; Psychology
SC Psychology
GA 836FF
UT WOS:000296094800003
PM 21672936
ER
PT J
AU Tate, DF
DeLong, A
McCaffrey, DE
Kertesz, K
Paul, RH
Conley, J
Russell, T
Coop, K
Gillani, F
Flanigan, T
Tashima, K
Hogan, JW
AF Tate, David F.
DeLong, Allison
McCaffrey, Daniel E.
Kertesz, Kinga
Paul, Robert H.
Conley, Jared
Russell, Troy
Coop, Kathleen
Gillani, Fizza
Flanigan, Timothy
Tashima, Karen
Hogan, Joseph W.
TI Recent Clinical History and Cognitive Dysfunction for Attention and
Executive Function among Human Immunodeficiency Virus-Infected Patients
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE HIV; Cognition; Neuropsychology; Executive function; Recent clinical
history
ID ACTIVE ANTIRETROVIRAL THERAPY; HIV-ASSOCIATED DEMENTIA; PLASMA VIRAL
LOAD; NEUROCOGNITIVE IMPAIRMENT; MEDICATION ADHERENCE;
CEREBROSPINAL-FLUID; CONTROLLED-TRIAL; SUBSTANCE-ABUSE; AIDS COHORT; ERA
AB This study examined the association between recent trends in CD4 and viral loads and cognitive test performance with the expectation that recent history could predict cognitive performance. Eighty-three human immunodeficiency virus (HIV)-infected patients with a mean CD4 count of 428 copies/ml were examined in this study (62% with undetectable plasma viral load [PVL]). We investigated the relationships between nadir CD4 cell count, 1-year trends in immunologic function/PVLs, and cognitive performance across several domains using linear regression models. Nadir CD4 cell count was predictive of current executive function (p = .004). One year clinical history for CD4 cell counts and/or PVLs were predictive of executive function, attention/working memory, and learning/memory measures (p < .05). Models that combined recent clinical history trends and nadir CD4 cell counts suggested that recent clinical trends were more important in predicting current cognitive performance for all domains except executive function. This research suggests that recent CD4 and viral load history is an important predictor of current cognitive function across several cognitive domains. If validated, clinical variables and cognitive dysfunction models may improve our understanding of the dynamic relationships between disease evolution and progression and CNS involvement.
C1 [Tate, David F.] Boston Univ, Med Ctr, Alzheimers Dis Ctr, Boston, MA USA.
[DeLong, Allison; Hogan, Joseph W.] Brown Univ, Ctr Stat Sci, Program Publ Hlth, Providence, RI 02912 USA.
[Paul, Robert H.] Univ Missouri, Dept Psychiat, St Louis, MO 63121 USA.
[Coop, Kathleen; Gillani, Fizza; Flanigan, Timothy; Tashima, Karen; Hogan, Joseph W.] Ctr AIDS Res, Providence, RI USA.
[Flanigan, Timothy; Tashima, Karen] Brown Univ, Dept Med, Warren Alpert Sch Med, Providence, RI 02912 USA.
[Tate, David F.; McCaffrey, Daniel E.; Kertesz, Kinga; Conley, Jared; Russell, Troy] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Imaging, Boston, MA 02115 USA.
RP Tate, DF (reprint author), Brooke Army Med Ctr, Def Ctr, Henry Jackson Fdn, San Antonio, TX USA.
EM dtate@dvbic.org
RI Hogan, Joseph/J-4579-2014;
OI Hogan, Joseph/0000-0001-7959-7361
FU [K23-MH073416]; [K23-MH065857]; [P30-AG013846]
FX This manuscript was supported in part by the following grants:
K23-MH073416 (D.F.T.), K23-MH065857 (R.H.P.), and P30-AG013846 (D.F.T.).
NR 47
TC 3
Z9 3
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD NOV
PY 2011
VL 26
IS 7
BP 614
EP 623
DI 10.1093/arclin/acr065
PG 10
WC Psychology, Clinical; Psychology
SC Psychology
GA 836FF
UT WOS:000296094800005
PM 21873325
ER
PT J
AU Pfluger, AR
Wu, WM
Pieja, AJ
Wan, J
Rostkowski, KH
Criddle, CS
AF Pfluger, Andrew R.
Wu, Wei-Min
Pieja, Allison J.
Wan, Jonathan
Rostkowski, Katherine H.
Criddle, Craig S.
TI Selection of Type I and Type II methanotrophic proteobacteria in a
fluidized bed reactor under non-sterile conditions
SO BIORESOURCE TECHNOLOGY
LA English
DT Article
DE Methanotrophic bacteria; Selection factor; Fluidized bed reactor;
Polyhydroxybutyrate
ID METHANE-OXIDIZING BACTERIA; TRICHLOROETHYLENE DEGRADATION; BIOFILM
REACTOR; GROWTH; FILM; POLYHYDROXYALKANOATES; BIODEGRADATION;
PERFORMANCE; CONSORTIUM; BIOMASS
AB Type II methanotrophs produce polyhydroxybutyrate (PHB), while Type I methanotrophs do not. A laboratory-scale fluidized bed reactor was initially inoculated with a Type II Methylocystis-like dominated culture. At elevated levels of dissolved oxygen (DO, 9 mg/L), pH of 6.2-6.5 with nitrate as the N-source, a Methylobacter-like Type I methanotroph became dominant within the biofilms which did not produce PHB. A shift to biofilms capable of PHB production was achieved by re-inoculating with Type II Methylosinus culture, providing dissolved N(2) as the N-source, and maintaining a low influent DO (2.0 mg/L). The resulting biofilms contained both Types I and II methanotrophs. Batch tests indicated that biofilm samples grown with N(2) became dominated by Type II methanotrophs and produced PHB. Enrichments with nitrate or ammonium were dominated by Type I methanotrophs without PHB production capability. The key selection factors favoring Type II were N(2) as N-source and low DO. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Wu, Wei-Min; Pieja, Allison J.; Wan, Jonathan; Rostkowski, Katherine H.; Criddle, Craig S.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[Pfluger, Andrew R.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA.
RP Wu, WM (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
EM billwu@stanford.edu; ccriddle@stanford.edu
FU California Environmental Protection Agency [07T3451]
FX This work was funded by the California Environmental Protection Agency
under Contract 07T3451. Special thanks to Mr. Bill Sabala for his
assistance with FBR modifications. We also thank Dr. Jeremy Semrau for
the Methylosinus trichosporium OB3b.
NR 36
TC 19
Z9 21
U1 1
U2 37
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0960-8524
J9 BIORESOURCE TECHNOL
JI Bioresour. Technol.
PD NOV
PY 2011
VL 102
IS 21
BP 9919
EP 9926
DI 10.1016/j.biortech.2011.08.054
PG 8
WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy &
Fuels
SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels
GA 836PS
UT WOS:000296124200014
PM 21906939
ER
PT J
AU Brewer, LM
Orr, JA
Sherman, MR
Fulcher, EH
Markewitz, BA
AF Brewer, L. M.
Orr, J. A.
Sherman, M. R.
Fulcher, E. H.
Markewitz, B. A.
TI Measurement of functional residual capacity by modified multiple breath
nitrogen washout for spontaneously breathing and mechanically ventilated
patients
SO BRITISH JOURNAL OF ANAESTHESIA
LA English
DT Article
DE lung, functional residual capacity; measurement techniques; model,
mathematical; monitoring, intensive care
ID EXPIRATORY LUNG-VOLUME; OXYGEN WASHIN-WASHOUT; INTENSIVE-CARE-UNIT;
HELIUM DILUTION; ACCURACY; GAS; TOMOGRAPHY; PRESSURE; FRACTION; SUPPORT
AB Background. There is a need for a bedside functional residual capacity (FRC) measurement method that performs well in intensive care patients during many modes of ventilation including controlled, assisted, spontaneous, and mixed. We developed a modified multiple breath nitrogen washout method for FRC measurement that relies on end-tidal gas fractions and alveolar tidal volume measurements as inputs but does not require the traditional measurements of volume of nitrogen or oxygen. Using end-tidal measurements, not volume, reduces errors from signal synchronization. This study was designed to assess the accuracy, precision, and repeatability of the proposed FRC system in subjects with variable ventilation patterns including some spontaneous effort.
Methods. The accuracy and precision of measurements were assessed by comparing the novel N-2 washout FRC values to the gold standard, body plethysmography, in 20 spontaneously breathing volunteers. Repeatability was assessed by comparing subsequent measurements in 20 intensive care patients whose lungs were under controlled and assisted mechanical ventilation.
Results. Compared with body plethysmography, the accuracy (mean bias) of the novel method was -0.004 litre and precision [1 standard deviation (SD)] was 0.209 litre [mean (SD)] [-0.1 (5.9)% of body plethysmography]. The difference between repeated measurements was 0.009 (0.15) litre [mean (SD)] [0.4 (6.4)%]. The coefficient of repeatability was 0.31 litre (12.7%).
Conclusions. The modified multiple breath nitrogen washout method for FRC measurement provides improved precision and equivalent accuracy and repeatability compared with existing methods during ventilation with variable ventilation patterns. Further study of the novel N-2 washout method is needed.
C1 [Brewer, L. M.; Orr, J. A.; Fulcher, E. H.; Markewitz, B. A.] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT 84132 USA.
[Sherman, M. R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Brewer, LM (reprint author), Univ Utah, Hlth Sci Ctr, 30 N 1900 E,Rm 3C444, Salt Lake City, UT 84132 USA.
EM lbrewer@abl.med.utah.edu
FU Philips-Respironics
FX This work was supported by research funding and monitoring equipment
from Philips-Respironics.
NR 29
TC 5
Z9 7
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-0912
J9 BRIT J ANAESTH
JI Br. J. Anaesth.
PD NOV
PY 2011
VL 107
IS 5
BP 796
EP 805
DI 10.1093/bja/aer220
PG 10
WC Anesthesiology
SC Anesthesiology
GA 834RN
UT WOS:000295981100021
PM 21752798
ER
PT J
AU Asplund, C
Chang, CJ
AF Asplund, Chad
Chang, Cindy J.
TI Care of the endurance athlete: promotion, perception, performance and
professionalism
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Editorial Material
ID CARDIORESPIRATORY FITNESS; EXERCISE; MEN
C1 [Asplund, Chad] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA.
[Chang, Cindy J.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
RP Asplund, C (reprint author), Eisenhower Army Med Ctr, Dept Family Med, 300 Hosp Dr, Ft Gordon, GA 30905 USA.
EM chad.asplund@gmail.com
NR 15
TC 0
Z9 0
U1 0
U2 2
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD NOV
PY 2011
VL 45
IS 14
BP 1083
EP 1084
DI 10.1136/bjsports-2011-090584
PG 2
WC Sport Sciences
SC Sport Sciences
GA 835UK
UT WOS:000296061300002
PM 22084824
ER
PT J
AU Asplund, CA
O'Connor, FG
Noakes, TD
AF Asplund, Chad A.
O'Connor, Francis G.
Noakes, Timothy D.
TI Exercise-associated collapse: an evidence-based review and primer for
clinicians
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Review
ID ORTHOSTATIC INTOLERANCE; HEAT-STRESS; POSTEXERCISE HYPOTENSION;
HEMODYNAMIC-RESPONSES; ULTRAMARATHON RUNNERS; POSTURAL HYPOTENSION;
ENDURANCE EXERCISE; NEGATIVE-PRESSURE; DYNAMIC EXERCISE; BLOOD-PRESSURE
AB Exercise-associated collapse (EAC) commonly occurs after the completion of endurance running events. EAC is a collapse in conscious athletes who are unable to stand or walk unaided as a result of light headedness, faintness and dizziness or syncope causing a collapse that occurs after completion of an exertional event. Although EAC is perhaps the most common aetiology confronted by the medical provider attending to collapsed athletes in a finish-line tent, providers must first maintain vigilance for other potential life-threatening aetiologies that cause collapse, such as cardiac arrest, exertional heat stroke or exercise-associated hyponatraemia. Previously, it has been believed that dehydration and hyperthermia were primary causes of EAC. On review of the evidence, EAC is now believed to be principally the result of transient postural hypotension caused by lower extremity pooling of blood once the athlete stops running and the resultant impairment of cardiac baroreflexes. Once life-threatening aetiologies are ruled out, treatment of EAC is symptomatic and involves oral hydration and a Trendelenburg position - total body cooling, intravenous hydration or advanced therapies is generally not needed.
C1 [Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA.
[O'Connor, Francis G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Noakes, Timothy D.] Univ Cape Town, MRC UCT Res Unit Exercise Sci & Sports Med, ZA-7925 Cape Town, South Africa.
[Noakes, Timothy D.] Sports Sci Inst S Africa, Dept Human Biol, Cape Town, South Africa.
RP Asplund, CA (reprint author), Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA.
EM chad.asplund@gmail.com
RI Noakes, Timothy/E-7253-2011
OI Noakes, Timothy/0000-0001-7244-2375
NR 50
TC 23
Z9 24
U1 0
U2 9
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD NOV
PY 2011
VL 45
IS 14
BP 1157
EP 1162
DI 10.1136/bjsports-2011-090378
PG 6
WC Sport Sciences
SC Sport Sciences
GA 835UK
UT WOS:000296061300016
PM 21948122
ER
PT J
AU Zhou, J
Brinckerhoff, C
Lubert, S
Yang, K
Saini, J
Hooke, J
Mural, R
Shriver, C
Somiari, S
AF Zhou, Jing
Brinckerhoff, Constance
Lubert, Susan
Yang, Kui
Saini, Jasmine
Hooke, Jeffrey
Mural, Richard
Shriver, Craig
Somiari, Stella
TI Analysis of Matrix Metalloproteinase-1 Gene Polymorphisms and Expression
in Benign and Malignant Breast Tumors
SO CANCER INVESTIGATION
LA English
DT Article
DE Breast cancers; Detection/diagnosis; Cancer biomarkers
ID SINGLE NUCLEOTIDE POLYMORPHISM; ACTIVATED PROTEIN-KINASE; SQUAMOUS-CELL
CARCINOMA; SALIVARY-GLAND CANCER; ETS BINDING-SITE; COLORECTAL-CANCER;
FIBROBLAST COLLAGENASE; PROMOTER POLYMORPHISM; PREDICTIVE MARKER;
OVARIAN-CANCER
AB A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.
C1 [Zhou, Jing; Lubert, Susan; Saini, Jasmine; Mural, Richard; Somiari, Stella] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA.
[Brinckerhoff, Constance] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA.
[Yang, Kui] Colorado Fdn Med Care, Englewood, CO USA.
[Hooke, Jeffrey; Shriver, Craig] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA.
RP Somiari, S (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA.
EM s.somiari@wriwindber.org
FU United States Department of Defense (Military Molecular Medicine
Initiative MDA) [W81XWHH-05-2-0075, Protocol 01-20006]; [NIH-AR-26599];
[NIH-CA-77267]
FX This research was supported by a grant from the United States Department
of Defense (Military Molecular Medicine Initiative MDA
W81XWHH-05-2-0075, Protocol 01-20006), and by NIH-AR-26599 and
NIH-CA-77267 to CB. The opinion and assertions contained herein are the
private views of the authors and are not to be construed as official or
as representing the views of the Department of the Army or the
Department of Defense.
NR 54
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U1 1
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0735-7907
J9 CANCER INVEST
JI Cancer Invest.
PD NOV
PY 2011
VL 29
IS 9
BP 599
EP 607
DI 10.3109/07357907.2011.621915
PG 9
WC Oncology
SC Oncology
GA 835DX
UT WOS:000296015900004
PM 22011282
ER
PT J
AU Gao, X
Jensen, RE
McKnight, SH
Gillespie, JW
AF Gao, X.
Jensen, R. E.
McKnight, S. H.
Gillespie, J. W., Jr.
TI Effect of colloidal silica on the strength and energy absorption of
glass fiber/epoxy interphases
SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
LA English
DT Article
DE Glass fibers; Interface/interphase; Micro-mechanics; Surface treatment
ID FIBER-REINFORCED COMPOSITES; FIBER/MATRIX INTERPHASE;
FRACTURE-TOUGHNESS; MATRIX INTERPHASE; SURFACE-TREATMENT; ADHESION;
SIZINGS; POLYPROPYLENE; COATINGS; SCRATCH
AB Prior research has demonstrated that fiber-sizings can be designed to yield composite materials that simultaneously possess high energy absorption and structural properties. The improved mechanical properties resulted from control of the fiber surface chemistry and nano-scale topological features within the fiber-matrix interphase. The present study further explains the role of sizing chemistry and surface roughness on composite material performance. Model and commercial glass fiber epoxy specimens were fabricated using these fiber sizing systems resulting in interphase regions with varied surface topology and chemical functionality. Micromechanical measurements were performed using the microdroplet adhesion test method to quantify the fiber-matrix interfacial properties. Improvement in energy absorption and interfacial shear strength due to the presence of the nano-scale silica were quantified. Inspection of the failure modes revealed that the existence of colloidal silica promotes crack propagation along a more tortuous path within the interphase that results in progressive failure and contributes to increased energy dissipation. Published by Elsevier Ltd.
C1 [Gao, X.; Gillespie, J. W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[Gao, X.; Gillespie, J. W., Jr.] Dept Mat Sci & Engn, Newark, DE 19716 USA.
[Gillespie, J. W., Jr.] Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Jensen, R. E.; McKnight, S. H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[McKnight, S. H.] Natl Sci Fdn, Arlington, VA 22230 USA.
RP Gao, X (reprint author), 3M Co, Bldg 0230-01-G-06, St Paul, MN 55144 USA.
EM xgaocomposite@gmail.com
FU Army Research Laboratory (ARMAC-RTP) [DAAD19-01-2-0001]; National
Science Foundation
FX Research was sponsored by the Army Research Laboratory (ARMAC-RTP) and
was accomplished under the ARMAC-RTP Cooperative Agreement Number
DAAD19-01-2-0001. Portions of the research conducted by McKnight were
supported by the National Science Foundation. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the Army Research Laboratory or the U.S. Government. The
U.S. Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon.
NR 42
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U1 5
U2 42
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-835X
J9 COMPOS PART A-APPL S
JI Compos. Pt. A-Appl. Sci. Manuf.
PD NOV
PY 2011
VL 42
IS 11
BP 1738
EP 1747
DI 10.1016/j.compositesa.2011.07.029
PG 10
WC Engineering, Manufacturing; Materials Science, Composites
SC Engineering; Materials Science
GA 837BY
UT WOS:000296167300019
ER
PT J
AU McLeod, DG
Dobi, A
AF McLeod, David G.
Dobi, Albert
TI Re: Antibody-Based Detection of ERG Rearrangement-Positive Prostate
Cancer
SO EUROPEAN UROLOGY
LA English
DT Editorial Material
C1 [McLeod, David G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA.
[Dobi, Albert] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA.
RP McLeod, DG (reprint author), Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA.
EM dgmcleod@verizon.net
NR 2
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0302-2838
J9 EUR UROL
JI Eur. Urol.
PD NOV
PY 2011
VL 60
IS 5
BP 1123
EP 1123
DI 10.1016/j.eururo.2011.08.036
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 836WW
UT WOS:000296149400051
PM 21961743
ER
PT J
AU Sabia, JJ
Rees, DI
AF Sabia, Joseph J.
Rees, Daniel I.
TI THE EFFECT OF BODY WEIGHT ON ADOLESCENT SEXUAL ACTIVITY
SO HEALTH ECONOMICS
LA English
DT Article
DE body weight; obesity; sex; sexual activity
ID FAMILY ENVIRONMENT; MASS INDEX; OBESITY; BEHAVIOR; RISK; DEPRESSION;
ADOPTION; GIRLS; MODEL
AB Recent research suggests that overweight females suffer penalties in the labor and marriage markets, while overweight males do not. This study explores whether similar gender differences in the effect of body weight exist in what Cawley et al. (2006) labeled 'the adolescent sex market'. Drawing on data from the National Longitudinal Study of Adolescent Health, we use fixed effects and instrumental variables identification strategies to estimate the relationship between body weight and sexual activity. We find evidence that increased body weight lowers the probability that female adolescents become sexually active. In contrast, there is little evidence of a causal relationship between body weight and sexual activity for male adolescents. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Sabia, Joseph J.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA.
[Rees, Daniel I.] Univ Colorado, Dept Econ, Denver, CO 80202 USA.
RP Sabia, JJ (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA.
EM Joseph.Sabia@usma.edu
FU National Institute of Child Health and Human Development [P01-HD31921]
FX The authors thank participants at the Population Association of America
and Western Economic Association International meetings for helpful
comments. This research uses data from Add Health, a program project
designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan
Harris, and funded by a grant P01-HD31921 from the National Institute of
Child Health and Human Development, with cooperative funding from 17
other agencies. Special acknowledgment is due Ronald R. Rindfuss and
Barbara Entwisle for assistance in the original design. Persons
interested in obtaining data files from Add Health should contact Add
Health, Carolina Population Center, 123 W. Franklin Street, Chapel Hill,
NC 27516-2524 (http://www.cpc.unc.edu/addhealth/contract.html). The
views expressed herein are those of the authors and do not reflect the
position of the United States Military Academy, the Department of the
Army, or the Department of Defense.
NR 33
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U1 2
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1057-9230
J9 HEALTH ECON
JI Health Econ.
PD NOV
PY 2011
VL 20
IS 11
BP 1330
EP 1348
DI 10.1002/hec.1674
PG 19
WC Economics; Health Care Sciences & Services; Health Policy & Services
SC Business & Economics; Health Care Sciences & Services
GA 836TB
UT WOS:000296133700004
PM 20960418
ER
PT J
AU Svensson, SP
Donetsky, D
Wang, D
Hier, H
Crowne, FJ
Belenky, G
AF Svensson, S. P.
Donetsky, D.
Wang, D.
Hier, H.
Crowne, F. J.
Belenky, G.
TI Growth of type II strained layer superlattice, bulk InAs and GaSb
materials for minority lifetime characterization
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article
DE Defects; Molecular beam epitaxy; Superlattices; Antimonides;
Semiconducting III-V materials; Infrared devices
ID NON-RADIATIVE TRANSITIONS; INAS/GASB SUPERLATTICES; INFRARED DETECTORS;
GAAS; SEMICONDUCTORS; CAPTURE
AB We have examined the growth of strained layer superlattice (SLS) structures for the purpose of characterizing and improving the minority carrier lifetime. Structures with different SL periods but with same absorption wavelength were first studied. Despite a doubling of the number of interfaces per thickness unit, no significant change was seen in the carrier lifetime. This observation points away from the interfaces as the location of lifetime limiting defect centers. To gain further insights into the spatial location of the defect centers, a series of binary InAs and GaSb layers grown with different substrate temperatures, were studied. We found that higher growth temperatures were beneficial for both binaries, although the improvement for GaSb was less than that of InAs. The substrate temperature was also varied in SLS structures and characterized with high-resolution x-ray diffraction. By using the peak width from the SLS zero-order diffraction as a figure of merit, we found a shallow growth window of similar to +/- 20 degrees around an optimum temperature of 440 degrees C. Outside this temperature window the material quality deteriorated very rapidly. Unfortunately, the substrate temperatures that would provide an improvement in the binary lifetimes fall mainly above the SLS growth window, thus limiting this parameter as a means of improving lifetimes in the SLS. A model that qualitatively relates bulk and SLS lifetimes through native defects is proposed and strategies for improving the lifetimes are discussed. Published by Elsevier B.V.
C1 [Svensson, S. P.; Hier, H.; Crowne, F. J.] USA, Res Lab, Adelphi, MD 20783 USA.
[Donetsky, D.; Wang, D.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RP Svensson, SP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Stefan.P.Svensson.civ@mail.mil
FU STTR [W911NF-09-C-0144]; NSF [DMR0710154]
FX This work was supported in part by STTR W911NF-09-C-0144 and by NSF,
Grant DMR0710154.
NR 29
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U1 3
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD NOV 1
PY 2011
VL 334
IS 1
BP 103
EP 107
DI 10.1016/j.jcrysgro.2011.08.030
PG 5
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA 838EG
UT WOS:000296269000017
ER
PT J
AU Grujicic, M
Bell, WC
Glomski, PS
Pandurangan, B
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Bell, W. C.
Glomski, P. S.
Pandurangan, B.
Yen, C. -F.
Cheeseman, B. A.
TI Filament-Level Modeling of Aramid-Based High-Performance Structural
Materials
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE filament-level modeling; Kevlar; microstructural defects; topological
defects
ID VINYL-ESTER-EPOXY; FORCE-FIELD; COMPASS; FIBERS
AB Molecular statics and molecular dynamics are employed to study the effects of various microstructural and topological defects (e.g., chain ends, axial chain misalignment, inorganic solvent impurities, and sheet stacking faults) on the strength, ductility, and stiffness of p-phenylene terephthalamide (PPTA) fibers/filaments. These fibers can be considered as prototypes for advanced high strength/high-stiffness fibers like Kevlar(A (R)), Twaron(A (R)), New Star(A (R)), etc. While modeling these fibers, it was taken into account that they are essentially crystalline materials consisting of stacks of sheets, with each sheet containing an array of nearly parallel hydrogen-bonded molecules/chains. The inter-sheet bonding, on the other hand, was considered as mainly being of van der Waals or p-electron character. The effects of various deviations of the PPTA fiber structure from that of the perfectly crystalline structure (i.e., microstructural/topological defects) on the material's mechanical properties are then considered. The results obtained show that while the presence of these defects decreases all the mechanical properties of PPTA fibers, specific properties display an increased level of sensitivity to the presence of certain defects. For example, longitudinal tensile properties are found to be most sensitive to the presence of chain ends, in-sheet transverse properties to the presence of chain misalignments, while cross-sheet transverse properties are found to be most affected by the presence of sheet stacking faults.
C1 [Grujicic, M.; Bell, W. C.; Glomski, P. S.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Weap & Mat Res Directorate Aberdeen, Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
EM gmica@clemson.edu
NR 15
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U1 0
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD NOV
PY 2011
VL 20
IS 8
BP 1401
EP 1413
DI 10.1007/s11665-010-9786-y
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA 834DV
UT WOS:000295940500008
ER
PT J
AU Steffen-Smith, EA
Shih, JH
Hipp, SJ
Bent, R
Warren, KE
AF Steffen-Smith, Emilie A.
Shih, Joanna H.
Hipp, Sean J.
Bent, Robyn
Warren, Katherine E.
TI Proton magnetic resonance spectroscopy predicts survival in children
with diffuse intrinsic pontine glioma
SO JOURNAL OF NEURO-ONCOLOGY
LA English
DT Article
DE Pediatric; Brain; Brainstem tumor; MRI; MR spectroscopy; Prognosis
ID BRAIN-STEM GLIOMAS; MR SPECTROSCOPY; STEREOTACTIC BIOPSY; IMAGING
BIOMARKERS; TUMORS; GRADE; RADIOTHERAPY; PERFUSION; PROGRESSION;
CEREBELLUM
AB Patients with diffuse intrinsic pontine glioma (DIPG) face a grim prognosis with limited treatment options. Many patients will enroll on investigational trials though the role of chemotherapy or immunotherapy is unclear. Radiographic changes on conventional MRI are used to evaluate tumor response and progression, but are not predictive of outcome in these patients. More sensitive measures of tumor biology are needed to improve patient management. We evaluated changes in magnetic resonance spectroscopy (MRS) biomarkers in patients with DIPG. Thirty-eight patients were enrolled prospectively on an IRB-approved protocol, which included standard MRI, single voxel spectroscopy (SVS) and multi-slice multi-voxel spectroscopy (MRSI). Scans were performed at multiple time points during each patient's clinical course, with a total of 142 scans. The prognostic values of Choline:N-acetylaspartate (Cho:NAA), Cho:Creatine (Cho:Cr) and the presence of lactate and lipids (+Lac/Lip) were evaluated. Cho:NAA and variance in Cho:NAA values among different voxels within a tumor were each predictive of shorter survival. This prospective study shows that MRS can be used to identify high-risk patients and monitor changes in tumor metabolism, which may reflect changes in tumor behavior.
C1 [Steffen-Smith, Emilie A.; Hipp, Sean J.; Bent, Robyn; Warren, Katherine E.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Shih, Joanna H.] NCI, Biometr Res Branch, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.
[Hipp, Sean J.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA.
[Hipp, Sean J.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
RP Warren, KE (reprint author), NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bldg 10,Room 1-5750,9000 Rockville Pike, Bethesda, MD 20892 USA.
EM warrenk@mail.nih.gov
OI Steffen-Smith, Emilie/0000-0002-4966-3046
FU National Institutes of Health, National Cancer Institute, Center for
Cancer Research
FX The authors thank Dr. Alan Barnett and Dr. Jan Willem van der Veen for
their contributions towards the MRSI acquisition and data analysis. This
work was presented in part at the ASNR 47th Annual Meeting, Vancouver
2009. Research was supported in part by the Intramural Research Program
of the National Institutes of Health, National Cancer Institute, Center
for Cancer Research. The views expressed in this article are those of
the authors and do not reflect the official policy of the National
Institutes of Health, Department of Army, Department of Defense, or U.S.
Government.
NR 56
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U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0167-594X
J9 J NEURO-ONCOL
JI J. Neuro-Oncol.
PD NOV
PY 2011
VL 105
IS 2
BP 365
EP 373
DI 10.1007/s11060-011-0601-x
PG 9
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA 835VK
UT WOS:000296064200027
PM 21567301
ER
PT J
AU Gunther, S
Feldmann, H
Geisbert, TW
Hensley, LE
Rollin, PE
Nichol, ST
Stroher, U
Artsob, H
Peters, CJ
Ksiazek, TG
Becker, S
ter Meulen, J
Olschlager, S
Schmidt-Chanasit, J
Sudeck, H
Burchard, GD
Schmiedel, S
AF Guenther, Stephan
Feldmann, Heinz
Geisbert, Thomas W.
Hensley, Lisa E.
Rollin, Pierre E.
Nichol, Stuart T.
Stroeher, Ute
Artsob, Harvey
Peters, Clarence J.
Ksiazek, Thomas G.
Becker, Stephan
ter Meulen, Jan
Oelschlaeger, Stephan
Schmidt-Chanasit, Jonas
Sudeck, Hinrich
Burchard, Gerd D.
Schmiedel, Stefan
TI Management of Accidental Exposure to Ebola Virus in the Biosafety Level
4 Laboratory, Hamburg, Germany
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID VESICULAR-STOMATITIS-VIRUS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES;
POSTEXPOSURE PROTECTION; RISK-FACTORS; INFECTION; TRANSMISSION;
INTERFERON; SUDAN; 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE
AB A needlestick injury occurred during an animal experiment in the biosafety level 4 laboratory in Hamburg, Germany, in March 2009. The syringe contained Zaire ebolavirus (ZEBOV) mixed with Freund's adjuvant. Neither an approved treatment nor a postexposure prophylaxis (PEP) exists for Ebola hemorrhagic fever. Following a risk-benefit assessment, it was recommended the exposed person take an experimental vaccine that had shown PEP efficacy in ZEBOV-infected nonhuman primates (NHPs) [12]. The vaccine, which had not been used previously in humans, was a live-attenuated recombinant vesicular stomatitis virus (recVSV) expressing the glycoprotein of ZEBOV. A single dose of 5 x 10(7) plaque-forming units was injected 48 hours after the accident. The vaccinee developed fever 12 hours later and recVSV viremia was detectable by polymerase chain reaction (PCR) for 2 days. Otherwise, the person remained healthy, and ZEBOV RNA, except for the glycoprotein gene expressed in the vaccine, was never detected in serum and peripheral blood mononuclear cells during the 3-week observation period.
C1 [Guenther, Stephan; Oelschlaeger, Stephan; Schmidt-Chanasit, Jonas] Bernhard Nocht Inst Trop Med, Dept Virol, D-20359 Hamburg, Germany.
[Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT USA.
[Geisbert, Thomas W.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA.
[Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Rollin, Pierre E.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA.
[Stroeher, Ute; Artsob, Harvey] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB, Canada.
[Peters, Clarence J.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX USA.
[Ksiazek, Thomas G.] Univ Texas Med Branch, Galveston Natl Lab, Dept Pathol, Galveston, TX USA.
[Becker, Stephan] Univ Marburg, Inst Virol, D-35032 Marburg, Germany.
[ter Meulen, Jan] Merck Res Labs, Vaccine Res, West Point, PA USA.
[Sudeck, Hinrich] Bundeswehrkrankenhaus Hamburg, Hamburg, Germany.
[Burchard, Gerd D.; Schmiedel, Stefan] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.
RP Gunther, S (reprint author), Bernhard Nocht Inst Trop Med, Dept Virol, Bernhard Nocht Str 74, D-20359 Hamburg, Germany.
EM guenther@bni.uni-hamburg.de
RI Becker, Stephan/A-1065-2010;
OI Becker, Stephan/0000-0002-2794-5659; Schmidt-Chanasit,
Jonas/0000-0003-4433-0231
NR 32
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U1 0
U2 30
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S785
EP S790
DI 10.1093/infdis/jir298
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400005
PM 21987751
ER
PT J
AU Hensley, LE
Alves, DA
Geisbert, JB
Fritz, EA
Reed, C
Larsen, T
Geisbert, TW
AF Hensley, Lisa E.
Alves, Derron A.
Geisbert, Joan B.
Fritz, Elizabeth A.
Reed, Christopher
Larsen, Tom
Geisbert, Thomas W.
TI Pathogenesis of Marburg Hemorrhagic Fever in Cynomolgus Macaques
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID DENDRITIC CELL-DIFFERENTIATION; ATTENUATED RECOMBINANT VACCINE;
NONHUMAN-PRIMATES; VIRUS DISEASE; GUINEA-PIGS; INFECTION; ANGOLA; EBOLA;
MONKEYS; IDENTIFICATION
AB Methods. Eighteen cynomolgus monkeys were infected with MARV; blood and tissues were examined sequentially over an 8-day period to investigate disease pathogenesis.
Results. Disease caused by MARV in cynomolgus macaques was very similar to disease previously described for Ebola virus-infected macaques. Monocytes, macrophages, Kupffer cells, and dendritic cells (DCs) were identified as the initial targets of MARV infection. Bystander lymphocyte apoptosis occurred at early stages in the disease course in intravascular and extravascular locations. The loss of splenic and lymph node DCs or downregulation of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) on DCs as early as day 2 and continuing through day 8 after MARV infection was a prominent finding. Evidence of disseminated intravascular coagulation was noted; however, the degree of fibrin deposition in tissues was less prominent than was reported in Ebola-infected macaques.
Conclusions. The sequence of pathogenic events identified in this study provides an understanding of the development of disease processes and also may provide new targets for rational prophylactic and chemotherapeutic interventions.
C1 [Geisbert, Joan B.; Fritz, Elizabeth A.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77550 USA.
[Geisbert, Joan B.; Fritz, Elizabeth A.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77550 USA.
[Hensley, Lisa E.; Reed, Christopher] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Alves, Derron A.; Larsen, Tom] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Geisbert, TW (reprint author), Univ Texas Med Branch, Galveston Natl Lab, 301 Univ Blvd, Galveston, TX 77550 USA.
EM tom.geisbert@utmb.edu
FU Defense Threat Reduction Agency; US Army Medical Research and Material
Command [02-4-4J-081]
FX This work was supported by the Defense Threat Reduction Agency and the
Medical Chemical/Biological Defense Research Program, US Army Medical
Research and Material Command (project number 02-4-4J-081).
NR 32
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U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S1021
EP S1031
DI 10.1093/infdis/jir339
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400038
PM 21987738
ER
PT J
AU Kortepeter, MG
Lawler, JV
Honko, A
Bray, M
Johnson, JC
Purcell, BK
Olinger, GG
Rivard, R
Hepburn, MJ
Hensley, LE
AF Kortepeter, Mark G.
Lawler, James V.
Honko, Anna
Bray, Mike
Johnson, Joshua C.
Purcell, Bret K.
Olinger, Gene G.
Rivard, Robert
Hepburn, Matthew J.
Hensley, Lisa E.
TI Real-time Monitoring of Cardiovascular Function in Rhesus Macaques
Infected With Zaire ebolavirus
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER; VIRUS INFECTION; POSTEXPOSURE PROTECTION; MARBURG
VIRUSES; SEVERE SEPSIS; SEPTIC SHOCK; GUINEA-PIGS; PATHOGENESIS;
MONKEYS; CONGO
AB Nine rhesus macaques were implanted with multisensor telemetry devices and internal jugular vein catheters before being infected with Zaire ebolavirus. All animals developed viremia, fever, a hemorrhagic rash, and typical changes of Ebola hemorrhagic fever in clinical laboratory tests. Three macaques unexpectedly survived this usually lethal disease, making it possible to compare physiological parameters in lethally challenged animals and survivors. After the onset of fever, lethal illness was characterized by a decline in mean arterial blood pressure, an increase in pulse and respiratory rate, lactic acidosis, and renal failure. Survivors showed less pronounced change in these parameters. Four macaques were randomized to receive supplemental volumes of intravenous normal saline when they became hypotensive. Although those animals had less severe renal compromise, no apparent survival benefit was observed. This is the first report of continuous physiologic monitoring in filovirus-infected nonhuman primates and the first to attempt cardiovascular support with intravenous fluids.
C1 [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med, Bethesda, MD 20814 USA.
[Kortepeter, Mark G.; Honko, Anna; Johnson, Joshua C.; Purcell, Bret K.; Olinger, Gene G.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Lawler, James V.] NIAID, Integrated Res Facil, Div Clin Res, NIH, Ft Detrick, MD USA.
[Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA.
[Rivard, Robert; Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA.
RP Kortepeter, MG (reprint author), Uniformed Serv Univ Hlth Sci, Clin Res Program, F Edward Hebert Sch Med, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd,Bldg 28,Rm 201, Bethesda, MD 20814 USA.
EM mkortepeter@idcrp.org
OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841;
Honko, Anna/0000-0001-9165-148X
FU Defense Threat Reduction Agency [4.10033_07_RD_B]
FX This work was supported by the Defense Threat Reduction Agency (Project
#4.10033_07_RD_B).
NR 25
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U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S1000
EP S1010
DI 10.1093/infdis/jir337
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400036
PM 21987736
ER
PT J
AU Raymond, J
Bradfute, S
Bray, M
AF Raymond, JoLynne
Bradfute, Steven
Bray, Mike
TI Filovirus Infection of STAT-1 Knockout Mice
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID EBOLA-VIRUS INFECTION; T-CELL RESPONSES; HEMORRHAGIC-FEVER; MOUSE MODEL;
IN-VITRO; APOPTOSIS; PATHOGENESIS; PROTECTION; DEFICIENCY; IMMUNITY
AB We evaluated the susceptibility to Ebola and Marburg virus infection of mice that cannot respond to interferon (IFN)-alpha/beta and IFN-gamma because of deletion of the STAT-1 gene. A mouse-adapted Zaire ebolavirus (ZEBOV) caused rapidly lethal disease; wild-type ZEBOV and Sudan Ebolavirus and 4 different Marburg virus strains produced severe, but more slowly progressive illness; and Reston Ebolavirus caused mild disease that was late in onset. The virulence of each agent was mirrored by the pace and severity of pathologic changes in the liver and lymphoid tissues. A virus-like particle vaccine elicited strong antibody responses but did not protect against mouse-adapted ZEBOV challenge.
C1 [Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA.
[Raymond, JoLynne] Armed Forces Inst Pathol, Dept Vet Pathol, Washington, DC 20306 USA.
[Bradfute, Steven] USA, Med Res Inst Infect Dis, Frederick, MD USA.
RP Bray, M (reprint author), NIAID, Div Clin Res, NIH, Room 1229F,6700 Rockledge Dr, Bethesda, MD 20892 USA.
EM mbray@niaid.nih.gov
NR 14
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U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S986
EP S990
DI 10.1093/infdis/jir335
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400034
PM 21987780
ER
PT J
AU Shabman, RS
Leung, DW
Johnson, J
Glennon, N
Gulcicek, EE
Stone, KL
Leung, L
Hensley, L
Amarasinghe, GK
Basler, CF
AF Shabman, Reed S.
Leung, Daisy W.
Johnson, Joshua
Glennon, Nicole
Gulcicek, Erol E.
Stone, Kathryn L.
Leung, Lawrence
Hensley, Lisa
Amarasinghe, Gaya K.
Basler, Christopher F.
TI DRBP76 Associates With Ebola Virus VP35 and Suppresses Viral Polymerase
Function
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID DOUBLE-STRANDED-RNA; INTERFERON INHIBITORY DOMAIN; RIBOSOME ENTRY SITE;
MARBURG-VIRUS; NUCLEOCAPSID PROTEINS; NUCLEAR FACTORS; NFAR PROTEINS;
BINDING; REPLICATION; DSRNA
AB The Zaire Ebola virus (EBOV) protein VP35 is multifunctional; it inhibits IFN-alpha/beta production and functions as a cofactor of the viral RNA polymerase. Mass spectrometry identified the double stranded RNA binding protein 76 (DRBP76/NFAR-1/NF90) as a cellular factor that associates with the VP35 C-terminal interferon inhibitory domain (IID). DRBP76 is described to regulate host cell protein synthesis and play an important role in host defense. The VP35-IID-DRBP76 interaction required the addition of exogenous dsRNA, but full-length VP35 associated with DRBP76 in the absence of exogenous dsRNA. Cells infected with a Newcastle disease virus (NDV)-expressing VP35 redistributed DRBP76 from the nucleus to the cytoplasm, the compartment in which EBOV replicates. Overexpression of DRBP76 did not alter the ability of VP35 to inhibit type I IFN production but did impair the function of the EBOV transcription/replication complex. These data suggest that DRBP76, via its association with VP35, exerts an anti-EBOV function.
C1 [Shabman, Reed S.; Glennon, Nicole; Leung, Lawrence; Basler, Christopher F.] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA.
[Leung, Daisy W.; Amarasinghe, Gaya K.] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA USA.
[Johnson, Joshua; Hensley, Lisa] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Gulcicek, Erol E.; Stone, Kathryn L.] Yale Univ, WM Keck Fdn Biotechnol Resource Lab, NBC Prote Core, New Haven, CT USA.
RP Basler, CF (reprint author), Mt Sinai Sch Med, Dept Microbiol, 1 Gustave L Levy Pl,Box 1124, New York, NY 10029 USA.
EM chris.basler@mssm.edu
RI Leung, Lawrence/E-4439-2010;
OI Leung, Lawrence/0000-0003-3333-3242; Amarasinghe,
Gaya/0000-0002-0418-9707; Johnson, Joshua/0000-0002-5677-3841; Shabman,
Reed/0000-0003-3272-3484
FU NIH [1R56AI089547, 1F32AI084324, R01AI059536, AI057158]; Northeast
Biodefense Center Proteomics Core-Lipkin; MRCE [U54AI057160-Virgin]; Roy
J. Carver Charitable Trust [09-3271]; [5F32AI084453]; [R01AI081914]
FX This work is supported by NIH grants (grant 1R56AI089547 to C. F. B. and
G. K. A., grant 1F32AI084324 to D. W. L., grants R01AI059536 and
AI057158 [Northeast Biodefense Center-Lipkin] to C. F. B.; Northeast
Biodefense Center Proteomics Core-Lipkin to E. E. G.; 5F32AI084453 to R.
S. S., and R01AI081914 to G. K. A.), an MRCE developmental grant (grant
U54AI057160-Virgin to G. K. A.), and the Roy J. Carver Charitable Trust
(grant 09-3271 to G. K. A.).
NR 38
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U1 0
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S911
EP S918
DI 10.1093/infdis/jir343
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400023
PM 21987769
ER
PT J
AU Yen, JY
Garamszegi, S
Geisbert, JB
Rubins, KH
Geisbert, TW
Honko, A
Xia, Y
Connor, JH
Hensley, LE
AF Yen, Judy Y.
Garamszegi, Sara
Geisbert, Joan B.
Rubins, Kathleen H.
Geisbert, Thomas W.
Honko, Anna
Xia, Yu
Connor, John H.
Hensley, Lisa E.
TI Therapeutics of Ebola Hemorrhagic Fever: Whole-Genome Transcriptional
Analysis of Successful Disease Mitigation
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID NONHUMAN-PRIMATES; GENE-EXPRESSION; VIRUS INFECTION; POSTEXPOSURE
TREATMENT; MARBURG VIRUSES; MICROARRAY DATA; IFN-ALPHA; PATHOGENESIS;
CELLS; PROTECTION
AB The mechanisms of Ebola (EBOV) pathogenesis are only partially understood, but the dysregulation of normal host immune responses (including destruction of lymphocytes, increases in circulating cytokine levels, and development of coagulation abnormalities) is thought to play a major role. Accumulating evidence suggests that much of the observed pathology is not the direct result of virus-induced structural damage but rather is due to the release of soluble immune mediators from EBOV-infected cells. It is therefore essential to understand how the candidate therapeutic may be interrupting the disease process and/or targeting the infectious agent. To identify genetic signatures that are correlates of protection, we used a DNA microarray-based approach to compare the host genome-wide responses of EBOV-infected nonhuman primates (NHPs) responding to candidate therapeutics. We observed that, although the overall circulating immune response was similar in the presence and absence of coagulation inhibitors, surviving NHPs clustered together. Noticeable differences in coagulation-associated genes appeared to correlate with survival, which revealed a subset of distinctly differentially expressed genes, including chemokine ligand 8 (CCL8/MCP-2), that may provide possible targets for early-stage diagnostics or future therapeutics. These analyses will assist us in understanding the pathogenic mechanisms of EBOV infection and in identifying improved therapeutic strategies.
C1 [Yen, Judy Y.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Garamszegi, Sara; Xia, Yu; Connor, John H.] Boston Univ, Bioinformat Program, Boston, MA 02118 USA.
[Geisbert, Joan B.; Geisbert, Thomas W.] Univ Texas Galveston, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77550 USA.
[Rubins, Kathleen H.] NASA, Houston, TX USA.
[Honko, Anna; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Xia, Yu] Boston Univ, Dept Biomed Engn, Boston, MA 02118 USA.
[Xia, Yu] Boston Univ, Dept Chem, Boston, MA 02118 USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, 72 E Concord St, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Connor, John/0000-0002-8867-7256; Xia, Yu/0000-0002-5596-5518; Honko,
Anna/0000-0001-9165-148X
FU Joint Science and Technology Office for Chemical and Biological Defense
[4.0021.08.RD.B]; Defense Threat Reduction Agency; Whitehead Institute
FX The Joint Science and Technology Office for Chemical and Biological
Defense and the Defense Threat Reduction Agency, JSTO-CBD
4.0021.08.RD.B, and the Whitehead Institute Fellows fund (to K. H. R.).
NR 37
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U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD NOV 1
PY 2011
VL 204
SU 3
BP S1043
EP S1052
DI 10.1093/infdis/jir345
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 834VD
UT WOS:000295991400040
PM 21987740
ER
PT J
AU Barnes, CM
Hollenbeck, JR
Jundt, DK
DeRue, DS
Harmon, SJ
AF Barnes, Christopher M.
Hollenbeck, John R.
Jundt, Dustin K.
DeRue, D. Scott
Harmon, Stephen J.
TI Mixing Individual Incentives and Group Incentives: Best of Both Worlds
or Social Dilemma?
SO JOURNAL OF MANAGEMENT
LA English
DT Article
DE interdependence; teamwork; compensation; incentives; teams; groups;
social dilemma
ID LEVEL PUBLIC-GOODS; FUTURE-RESEARCH; COOPERATION; PERFORMANCE; TEAMS;
INTERDEPENDENCE; PROVISION; RESOURCE; BEHAVIOR; BACKING
AB Equity theory emphasizes making distinctions between individual contributions to teams and then recognizing these with differentiations in rewards. However, social interdependence theory emphasizes maximizing cooperation in teams by compensating members equally. Several researchers have advocated offsetting the limitations of individually based incentives and group-based incentives by mixing the two. However, the authors contend that this puts team members in a social dilemma, leading them to focus on the individually based component. The authors find that in comparison to group-based only incentives, mixed individual/group incentives lead team members to perform faster but less accurately and focus on their own taskwork to the detriment of backing up behavior.
C1 [Barnes, Christopher M.] US Mil Acad, West Point, NY 10996 USA.
[Hollenbeck, John R.] Michigan State Univ, E Lansing, MI 48824 USA.
[Jundt, Dustin K.] St Louis Univ, St Louis, MO 63103 USA.
[DeRue, D. Scott] Univ Michigan, Ann Arbor, MI 48109 USA.
RP Barnes, CM (reprint author), Virginia Tech, 2007 Pamplin, Blacksburg, VA 24061 USA.
EM cmbarnes@vt.edu
RI Barnes, Christopher/O-4814-2014
OI Barnes, Christopher/0000-0003-2520-6200
NR 66
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U1 8
U2 64
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0149-2063
EI 1557-1211
J9 J MANAGE
JI J. Manag.
PD NOV
PY 2011
VL 37
IS 6
BP 1611
EP 1635
DI 10.1177/0149206309360845
PG 25
WC Business; Psychology, Applied; Management
SC Business & Economics; Psychology
GA 830WT
UT WOS:000295690200005
ER
PT J
AU Frattaroli, S
Gielen, AC
Piver-Renna, J
Pollack, KM
Ta, VM
AF Frattaroli, Shannon
Gielen, Andrea C.
Piver-Renna, Jennifer
Pollack, Keshia M.
Ta, Van M.
TI Fire Prevention in Delaware: A Case Study of Fire and Life Safety
Initiatives
SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
LA English
DT Article
DE case study; fire prevention; fire service
ID UNITED-STATES; INJURIES
AB Context: Injuries resulting from residential house fires are a significant public health issue. The fire service is engaged in fire prevention activities aimed at preventing fire-related morbidity and mortality. The fire service in Delaware is regarded by some leaders in the field as a model for fire and life safety education (FLSE). Objective: We identified 3 questions to guide this research. What is the culture and context of fire prevention in Delaware? What prevention programs and policies constitute Delaware's fire prevention efforts? What can be learned from select model programs regarding their impact, sustainability, strengths, limitations, and general applicability? A discussion of the lessons learned from Delaware's experience with FLSE initiatives concludes the article. Design: We used a single case study design and collected and analyzed data from in-depth interviews, documents, and participant observation notes to address the research questions. Setting: Data were collected in Delaware. Participants: Interviewees included a purposeful sample of members of the Delaware fire service. Main Outcome Measures: Descriptions of the context in which fire prevention occurs, the initiatives underway, and the factors associated with successfully supporting fire prevention in the state. Results: Data from 16 key informant interviews, relevant documents, and direct observations of FLSE events revealed a fire service rooted in tradition, dedication, and community. A compilation of state and local FLSE initiatives illustrates the diversity of FLSE in Delaware. Thematic analysis of the data emphasize the importance of a strategic, comprehensive, and coordinated approach to realizing success in Delaware's approach to FLSE. Conclusions: The fire service is an important part of the public health infrastructure. While their role as first responders is evident, their contributions to prevention are also significant. This research suggests ways to support fire service prevention efforts and more fully integrate their FLSE work into the public health infrastructure.
C1 [Frattaroli, Shannon; Gielen, Andrea C.; Pollack, Keshia M.] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Injury Res & Policy, Baltimore, MD USA.
[Piver-Renna, Jennifer] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
[Ta, Van M.] San Jose State Univ, Dept Hlth Sci, San Jose, CA 95192 USA.
RP Frattaroli, S (reprint author), 624 N Broadway,5th Floor, Baltimore, MD 21205 USA.
EM sfrattar@jhsph.edu
FU PHS HHS [R49CCR302486]
NR 19
TC 1
Z9 1
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1078-4659
J9 J PUBLIC HEALTH MAN
JI J. Public Health Manag. Pract.
PD NOV-DEC
PY 2011
VL 17
IS 6
BP 492
EP 498
DI 10.1097/PHH.0b013e318211396b
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 827BI
UT WOS:000295400100004
PM 21964358
ER
PT J
AU Nie, X
Prabhu, R
Chen, WW
Caruthers, JM
Weerasooriya, T
AF Nie, X.
Prabhu, R.
Chen, W. W.
Caruthers, J. M.
Weerasooriya, T.
TI A Kolsky Torsion Bar Technique for Characterization of Dynamic Shear
Response of Soft Materials
SO EXPERIMENTAL MECHANICS
LA English
DT Article
DE Kolsky torsion bar; Soft materials; High strain rate; Shear response;
Inertia effects
ID HOPKINSON PRESSURE BAR; MECHANICAL-PROPERTIES; HUMAN TISSUES;
BRAIN-TISSUE; INERTIA; COMPRESSION; PORCINE; MUSCLE
AB A novel Kolsky torsion bar technique is developed and successfully utilized to characterize the high strain rate shear response of a rate-independent end-linked polydimethylsiloxane (PDMS) gel rubber with a shear modulus of about10 KPa. The results show that the specimen deforms uniformly under constant strain rate and the measured dynamic shear modulus follows reasonably well the trend determined by dynamic mechanical analysis (DMA) at lower strain rates. For comparison, Kolsky compression bar experiments are also performed on the same gel material with annular disk specimens. The dynamic moduli obtained from compression experiments, however, are an order of magnitude higher than those obtained by the torsional technique, due to the pressure caused by the radial inertia and end constraints.
C1 [Nie, X.; Chen, W. W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
[Prabhu, R.; Caruthers, J. M.] Purdue Univ, Sch Chem Engn, W Lafayette, IN 47907 USA.
[Chen, W. W.] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA.
[Weerasooriya, T.] USA, Res Lab, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
RP Nie, X (reprint author), Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
EM xnie@purdue.edu
NR 29
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U1 1
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4851
J9 EXP MECH
JI Exp. Mech.
PD NOV
PY 2011
VL 51
IS 9
BP 1527
EP 1534
DI 10.1007/s11340-011-9481-4
PG 8
WC Materials Science, Multidisciplinary; Mechanics; Materials Science,
Characterization & Testing
SC Materials Science; Mechanics
GA 829UT
UT WOS:000295610500008
ER
PT J
AU Sears, AK
Perez, SA
Clifton, GT
Benavides, LC
Gates, JD
Clive, KS
Holmes, JP
Shumway, NM
Van Echo, DC
Carmichael, MG
Ponniah, S
Baxevanis, CN
Mittendorf, EA
Papamichail, M
Peoples, GE
AF Sears, Alan K.
Perez, Sonia A.
Clifton, Guy T.
Benavides, Linda C.
Gates, Jeremy D.
Clive, Kevin S.
Holmes, Jarrod P.
Shumway, Nathan M.
Van Echo, David C.
Carmichael, Mark G.
Ponniah, Sathibalan
Baxevanis, Constantin N.
Mittendorf, Elizabeth A.
Papamichail, Michael
Peoples, George E.
TI AE37: a novel T-cell-eliciting vaccine for breast cancer
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Article
DE AE36 peptide; AE37 vaccine; breast cancer; cancer vaccines; Ii-Key
hybrid; prostate cancer
ID GROUP-STUDY I-01; ADJUVANT CHEMOTHERAPY; PEPTIDE VACCINES;
CLINICAL-TRIAL; OVARIAN-CANCER; E75 VACCINE; HER-2/NEU; TRASTUZUMAB;
EXPRESSION; GENERATION
AB Introduction: Immunotherapy, including vaccines targeting the human EGFR2 (HER-2/neu) protein, is an active area of investigation in combatting breast cancer. Several vaccines are currently undergoing clinical trials, most of which are CD8(+) T-cell-eliciting vaccines. AE37 is a promising primarily CD4(+) T-cell-eliciting HER-2/neu breast cancer vaccine currently in clinical trials.
Areas covered: This article reviews preclinical investigations as well as findings from completed and ongoing Phase I and Phase II clinical trials of the AE37 vaccine.
Expert opinion: Clinical trials have shown the AE37 vaccine to be safe and capable of generating peptide-specific, durable immune responses. This has been shown in patients with any level of HER-2/neu expression. Early clinical findings suggest there may be benefit to AE37 vaccination in preventing breast cancer recurrence.
C1 [Sears, Alan K.; Clifton, Guy T.; Benavides, Linda C.; Gates, Jeremy D.; Clive, Kevin S.; Shumway, Nathan M.; Peoples, George E.] Brooke Army Med Ctr, Dept Gen Surg, Ft Sam Houston, TX 78234 USA.
[Perez, Sonia A.; Baxevanis, Constantin N.; Papamichail, Michael] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece.
[Holmes, Jarrod P.] USN, San Diego Med Ctr, San Diego, CA USA.
[Van Echo, David C.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
[Carmichael, Mark G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Ponniah, Sathibalan] Canc Vaccine Dev Lab, Bethesda, MD USA.
[Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Gen Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM george.peoples@us.army.mil
FU Antigen Express, Inc.; Antigen Express for clinical trials
FX The studies in the paper have been primarily funded by Antigen Express,
Inc. Additional support has been provided by the United States Military
Cancer Institute. Dr Peoples has received grant support from Antigen
Express for clinical trials. He also has partial inventor rights to AE37
and is eligible to receive proceeds related to patents. He is also a
consultant to Generex, Inc. The other authors declare no conflicts of
interest.
NR 32
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Z9 22
U1 0
U2 8
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1471-2598
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD NOV
PY 2011
VL 11
IS 11
BP 1543
EP 1550
DI 10.1517/14712598.2011.616889
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 829WM
UT WOS:000295616200013
PM 21895539
ER
PT J
AU Fox, DM
Huang, X
Jung, D
Fourney, WL
Leiste, U
Lee, JS
AF Fox, D. M.
Huang, X.
Jung, D.
Fourney, W. L.
Leiste, U.
Lee, J. S.
TI The response of small scale rigid targets to shallow buried explosive
detonations
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Mine blast; Small-scale experiments; Soil model; Computational
mechanics; Arbitrary Lagrangian-Eulerian method
ID SATURATION; MODEL; SAND
AB Experimental and computational investigations were performed in order to better understand the mechanical response of rigid targets with various geometries to the detonation of shallow buried explosives. The motion of the targets was measured by use of high-speed digital video photography. This work involved flat targets, targets that were downwardly convex, and targets that were downwardly concave with explosive charges located at various positions beneath the targets. It was observed that, in general, angled hulls - whether downwardly concave or convex - tended to reduce the amount of momentum imparted to the center of mass of the targets. Computations were performed by use of an arbitrary Langrangian-Eulerian treatment in a nonlinear finite element code. A model based on quasi-static test evaluations of wet concrete sand was used for prediction of the soil behavior. The computational technique provided very good agreement between computation and experiment. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Lee, J. S.] Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea.
[Fox, D. M.; Huang, X.] USA, Res Lab, Blast Protect Branch, Proving Ground, MD 21005 USA.
[Jung, D.; Fourney, W. L.; Leiste, U.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
[Fox, D. M.] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA.
RP Lee, JS (reprint author), Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea.
EM joonlee@yonsei.ac.kr
FU US Army Tank-Automotive Research, Development and Engineering Center;
Center for Energetic Concepts at the University of Maryland
FX The authors wish to thank Leslie Taylor from the University of Maryland,
Chian-Fong Yen, Scott Kukuck, and Douglas Kooker from the US Army
Research Laboratory as well as Erin Williams, Kent Danielson, Jon
Windham, and Steve Akers from the US Engineer Research and Development
Center for various insights with regard to the interaction of soils and
shallow buried explosives. The authors are also grateful to the US Army
Tank-Automotive Research, Development and Engineering Center and the
Center for Energetic Concepts at the University of Maryland for the
support they provided for this work.
NR 19
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U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD NOV
PY 2011
VL 38
IS 11
BP 882
EP 891
DI 10.1016/j.ijimpeng.2011.05.009
PG 10
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA 828LJ
UT WOS:000295502200003
ER
PT J
AU Parikh, N
Wiernikowski, JT
Sholler, G
Roberts, S
Howard, S
Shochat, S
Haase, G
Borker, A
Kurkure, PA
Sachdeva, A
Matthay, KK
AF Parikh, Nehal
Wiernikowski, John T.
Sholler, Giselle
Roberts, Stephen
Howard, Scott
Shochat, Stephen
Haase, Gerald
Borker, Anupuma
Kurkure, Purna A.
Sachdeva, Anupam
Matthay, Katherine K.
TI ADVANCING DIAGNOSIS AND TREATMENT OF NEUROBLASTOMA FOR CHILDREN IN LOW
INCOME COUNTRIES (LIC) VIA WEB-BASED TUMOR BOARD PLATFORM
SO PEDIATRIC BLOOD & CANCER
LA English
DT Meeting Abstract
C1 [Parikh, Nehal] Connecticut Childrens Med Ctr, Div Pediat Hematol Oncol, Hartford, CT USA.
[Wiernikowski, John T.] McMaster Childrens Hosp, Hamilton, ON, Canada.
[Sholler, Giselle] Univ Vermont, Dept Pediat, Burlington, VT USA.
[Roberts, Stephen] Walter Reed Army Med Ctr, Dept Pediat Hematol Oncol, Bethesda, MD USA.
[Howard, Scott; Shochat, Stephen] St Jude Childrens Hosp, Memphis, TN 38105 USA.
[Haase, Gerald] Childrens Hosp, Aurora, CO USA.
[Borker, Anupuma] Kasturba Med Coll & Hosp, Manipal, Karnataka, India.
[Kurkure, Purna A.] Tata Mem Hosp, Mumbai 400012, Maharashtra, India.
[Sachdeva, Anupam] Sir Ganga Ram Hosp, Dept Pediat, New Delhi, India.
[Matthay, Katherine K.] UCSF Benioff Childrens Hosp, San Francisco, CA USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU WILEY PERIODICALS, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA
SN 1545-5009
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD NOV
PY 2011
VL 57
IS 5
BP 733
EP 733
PG 1
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 824ZB
UT WOS:000295239600105
ER
PT J
AU Nilakantan, G
Keefe, M
Wetzel, ED
Bogetti, TA
Gillespie, JW
AF Nilakantan, Gaurav
Keefe, Michael
Wetzel, Eric D.
Bogetti, Travis A.
Gillespie, John W., Jr.
TI Computational modeling of the probabilistic impact response of flexible
fabrics
SO COMPOSITE STRUCTURES
LA English
DT Article
DE Aramid fiber; Flexible composites; Woven fabrics; Impact behavior;
Finite element analysis (FEA); Probabilistic methods
ID FINITE-ELEMENT MODEL; BALLISTIC IMPACT; ENERGY-ABSORPTION; WOVEN
FABRICS; STRENGTH; FIBERS; SENSITIVITY; PERFORMANCE; FRICTION; GEOMETRY
AB The impact response of flexible woven fabrics is probabilistic in nature and described through a probabilistic velocity response curve or V(0)-V(100) curve. Computational impact analyses based on deterministic methods are incapable of predicting the experimentally observed probabilistic fabric impact response. To overcome this limitation we have developed a probabilistic computational framework within a finite element analysis to predict the V(0)-V(100) response. The finite element model is a yarn-based representation of the fabric architecture, with a principal stress based failure criterion implemented uniformly within each yarn, but varying for each yarn within the fabric. For each impact simulation, individual yarn strengths are mapped from experimentally obtained yarn strength distributions, resulting in fabric models with spatially non-uniform failure conditions. Impact simulations are run for the case of a spherical projectile of diameter 5.556 mm impacting a single layer of 50.8 x 50.8 mm, edge-clamped, unbacked, aramid fabric. Three different yarn strength models are implemented, representing spool yarns, and yarns extracted from greige and scoured woven fabrics. Decreases in yarn strength are found to correlate to decreases in the V(1), V(50), and V(99) velocities predicted by the simulations. The relationships between yarn strength distribution and probabilistic fabric impact response are discussed. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Nilakantan, Gaurav; Keefe, Michael; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA.
[Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
[Wetzel, Eric D.; Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
EM gillespi@udel.edu
RI Nilakantan, Gaurav/B-8643-2012
OI Nilakantan, Gaurav/0000-0002-5375-9681
FU Army Research Laboratory
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-06-2-0011. The
views and conclusions contained in this document are those of the
authors and should not be interested as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the US Government. The US Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 32
TC 18
Z9 20
U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-8223
J9 COMPOS STRUCT
JI Compos. Struct.
PD NOV
PY 2011
VL 93
IS 12
BP 3163
EP 3174
DI 10.1016/j.compstruct.2011.06.013
PG 12
WC Materials Science, Composites
SC Materials Science
GA 821OP
UT WOS:000294984600008
ER
PT J
AU Koellhoffer, S
Gillespie, JW
Advani, SG
Bogetti, TA
AF Koellhoffer, Steve
Gillespie, John W., Jr.
Advani, Suresh G.
Bogetti, Travis A.
TI Role of friction on the thermal development in ultrasonically
consolidated aluminum foils and composites
SO JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
LA English
DT Article
DE Ultrasonic consolidation; Aluminum; Friction coefficient; Metal matrix
composite
ID DEFORMATION; FABRICATION; MATRIX; FIBERS; ALLOY
AB Ultrasonic consolidation is a solid-state bonding process capable of producing metal and metal matrix composite parts. In this work a friction-based heat generation model is proposed to characterize the thermal development of ultrasonically consolidated aluminum foils and continuous fiber alumina reinforced aluminum metal matrix composite tape as a function of process control parameters. The friction coefficient between mating surfaces is determined experimentally, and the credibility of using both a constant friction coefficient and a process dependent friction coefficient is assessed. In most cases a constant friction coefficient is capable of producing results that are within 15% error; while a process dependent friction coefficient achieves an average error of 7%. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Koellhoffer, Steve; Gillespie, John W., Jr.; Advani, Suresh G.] Univ Delaware, Ctr Compos Mat, Newark, DE 19716 USA.
[Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Advani, SG (reprint author), Univ Delaware, Ctr Compos Mat, Newark, DE 19716 USA.
EM advani@udel.edu
FU Army Research Laboratory (ARL); Composite Materials Research program
FX We would like to thank the Army Research Laboratory (ARL) for support of
this research and for funding through the Composite Materials Research
program.
NR 34
TC 10
Z9 12
U1 0
U2 4
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0924-0136
J9 J MATER PROCESS TECH
JI J. Mater. Process. Technol.
PD NOV
PY 2011
VL 211
IS 11
BP 1864
EP 1877
DI 10.1016/j.jmatprotec.2011.06.011
PG 14
WC Engineering, Industrial; Engineering, Manufacturing; Materials Science,
Multidisciplinary
SC Engineering; Materials Science
GA 815FO
UT WOS:000294511700025
ER
PT J
AU Grujicic, M
Pandurangan, B
Bell, WC
Cheeseman, BA
Patel, P
Gazonas, GA
AF Grujicic, M.
Pandurangan, B.
Bell, W. C.
Cheeseman, B. A.
Patel, P.
Gazonas, G. A.
TI Molecular-level analysis of shock-wave physics and derivation of the
Hugoniot relations for soda-lime glass
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID BRITTLE MATERIALS; MECHANICAL-PROPERTIES; FORCE-FIELD; DYNAMICS; MODEL;
FRAGMENTATION; TRANSITION; PRESSURE; COMPASS; SOLIDS
AB Non-equilibrium and equilibrium molecular dynamics simulations are employed to study the mechanical response of soda-lime glass (a material commonly used in transparent armor applications) when subjected to the loading conditions associated with the generation and propagation of planar shock waves. Particular attention is given to the identification and characterization of various (inelastic-deformation and energy-dissipation) molecular-level phenomena and processes taking place at the shock front. The results obtained revealed that the shock loading causes a 2-4% (shock strength-dependent) density increase. In addition, an increase in the average coordination number of the silicon atoms is observed along with the creation of smaller Si-O rings. These processes are associated with significant energy absorption and dissipation and are believed to control the blast/ballistic impact mitigation potential of soda-lime glass. This study was also aimed at the determination (via purely computational means) of the shock Hugoniot (i.e., a set of axial stress vs. density/specific-volume vs. internal energy vs. particle velocity vs. temperature) material states obtained in soda-lime glass after the passage of a shock wave of a given strength and on the comparison of the computed results with their experimental counterparts. The availability of a shock Hugoniot is critical for construction of a high deformation-rate, large-strain, high pressure material model which can be used within a continuum-level computational analysis to capture the response of a soda-lime glass-based laminated transparent armor structure (e.g., a military vehicle windshield, door window, etc.) to blast/ballistic impact loading.
C1 [Grujicic, M.; Pandurangan, B.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Cheeseman, B. A.; Patel, P.; Gazonas, G. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@exchange.clemson.edu
OI Gazonas, George/0000-0002-2715-016X
FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042];
ARC-TARDEC
FX The material presented in this article is based on study supported by
the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024
and W911NF-06-2-0042 and by an ARC-TARDEC research contract.
NR 30
TC 11
Z9 11
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD NOV
PY 2011
VL 46
IS 22
SI SI
BP 7298
EP 7312
DI 10.1007/s10853-011-5691-5
PG 15
WC Materials Science, Multidisciplinary
SC Materials Science
GA 809NV
UT WOS:000294064900031
ER
PT J
AU Lavoie, J
Srinivasan, S
Nagarajan, R
AF Lavoie, J.
Srinivasan, Sree
Nagarajan, R.
TI Using cheminformatics to find simulants for chemical warfare agents
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Chemical warfare agents; Molecular descriptors; Simulants; Similarity
search; Tanimoto coefficient; Euclidean distance
ID DRUG DISCOVERY; FINGERPRINT METHODS
AB Direct experimentation with chemical warfare agents (CWA) to study important problems such as their permeation across protective barrier materials, decontamination of equipment and facilities, or the environmental transport and fate of CWAs is not feasible because of the obvious toxicity of the CM/As and associated restrictions on their laboratory use. The common practice is to use "simulants," namely, analogous chemicals that closely resemble the CWAs but are less toxic, with the expectation that the results attained for simulants can be correlated to how the CWAs would perform. Simulants have been traditionally chosen by experts, by means of intuition, using similarity in one or more physical properties (such as vapor pressure or aqueous solubility) or in the molecular structural features (such as functional groups) between the stimulant and the CWA. This work is designed to automate the simulant identification process backed by quantitative metrics, by means of chemical similarity search software routinely used in pharmaceutical drug discovery. The question addressed here is: By the metrics of such software, how similar are traditional simulants to CWAs? That is, what is the numerical "distance" between each CWA and its customary simulants in the quantitative space of molecular descriptors? The answers show promise for finding close but less toxic simulants for the ever-increasing numbers of CWAs objectively and fast. Published by Elsevier B.V.
C1 [Lavoie, J.; Srinivasan, Sree; Nagarajan, R.] USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Nagarajan, R (reprint author), USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Ctr, 15 Kansas St, Natick, MA 01760 USA.
EM Ramanathan.Nagarajan@us.army.mil
OI Nagarajan, Ramanathan/0000-0003-4758-2231
FU U.S. Army Natick Soldier Research, Development & Engineering Center;
Defense Threat Reduction Agency [BA10PHM050]
FX The work was supported by an Early Applied Research (EAR) award from the
U.S. Army Natick Soldier Research, Development & Engineering Center and
by the Defense Threat Reduction Agency Project # BA10PHM050. The authors
thank Strand Life Sciences personnel (chiefly K. Subramanian, K.
Sumathy, and A. Das) for custom scripts and numerous discussions on
Sarchitect (R) usage.
NR 23
TC 10
Z9 10
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD OCT 30
PY 2011
VL 194
BP 85
EP 91
DI 10.1016/j.jhazmat.2011.07.077
PG 7
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 845KQ
UT WOS:000296822000012
PM 21872989
ER
PT J
AU Epstein, JE
Tewari, K
Lyke, KE
Sim, BKL
Billingsley, PF
Laurens, MB
Gunasekera, A
Chakravarty, S
James, ER
Sedegah, M
Richman, A
Velmurugan, S
Reyes, S
Li, M
Tucker, K
Ahumada, A
Ruben, AJ
Li, T
Stafford, R
Eappen, AG
Tamminga, C
Bennett, JW
Ockenhouse, CF
Murphy, JR
Komisar, J
Thomas, N
Loyevsky, M
Birkett, A
Plowe, CV
Loucq, C
Edelman, R
Richie, TL
Seder, RA
Hoffman, SL
AF Epstein, J. E.
Tewari, K.
Lyke, K. E.
Sim, B. K. L.
Billingsley, P. F.
Laurens, M. B.
Gunasekera, A.
Chakravarty, S.
James, E. R.
Sedegah, M.
Richman, A.
Velmurugan, S.
Reyes, S.
Li, M.
Tucker, K.
Ahumada, A.
Ruben, A. J.
Li, T.
Stafford, R.
Eappen, A. G.
Tamminga, C.
Bennett, J. W.
Ockenhouse, C. F.
Murphy, J. R.
Komisar, J.
Thomas, N.
Loyevsky, M.
Birkett, A.
Plowe, C. V.
Loucq, C.
Edelman, R.
Richie, T. L.
Seder, R. A.
Hoffman, S. L.
TI Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic
CD8(+) T Cell Immunity
SO SCIENCE
LA English
DT Article
ID SPOROZOITE SURFACE PROTEIN-2; PLASMODIUM-FALCIPARUM SPOROZOITES;
CIRCUMSPOROZOITE PROTEIN; INFECTED HEPATOCYTES; PREERYTHROCYTIC STAGES;
GAMMA-INTERFERON; IMMUNIZATION; RESPONSES; HUMANS; MICE
AB Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in >= 80% of recipients. Pf sporozoites (Pf SPZ) administered by mosquito bites are the only immunogens shown to induce such protection in humans. Such protection is thought to be mediated by CD8(+) T cells in the liver that secrete interferon-gamma (IFN-gamma). We report that purified irradiated Pf SPZ administered to 80 volunteers by needle inoculation in the skin was safe, but suboptimally immunogenic and protective. Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of Pf SPZ-specific CD8(+), IFN-gamma-producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). Our results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Pf malaria.
C1 [Tewari, K.; Seder, R. A.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA.
[Epstein, J. E.; Sedegah, M.; Reyes, S.; Tamminga, C.; Thomas, N.; Richie, T. L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA.
[Lyke, K. E.; Laurens, M. B.; Plowe, C. V.; Edelman, R.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Sim, B. K. L.; Billingsley, P. F.; Gunasekera, A.; Chakravarty, S.; James, E. R.; Richman, A.; Velmurugan, S.; Ahumada, A.; Ruben, A. J.; Li, T.; Stafford, R.; Eappen, A. G.; Loyevsky, M.; Hoffman, S. L.] Sanaria Inc, Rockville, MD 20850 USA.
[Sim, B. K. L.; Li, M.; Ahumada, A.; Stafford, R.; Hoffman, S. L.] Prot Potential LLC, Rockville, MD 20850 USA.
[Laurens, M. B.; Plowe, C. V.] Howard Hughes Med Inst, Baltimore, MD 21201 USA.
[Tucker, K.] Stat Collaborat Inc, Washington, DC 20036 USA.
[Bennett, J. W.; Ockenhouse, C. F.; Murphy, J. R.; Komisar, J.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA.
[Birkett, A.; Loucq, C.] PATH Malaria Vaccine Initiat, Bethesda, MD 20814 USA.
RP Seder, RA (reprint author), NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM rseder@mail.nih.gov; slhoffman@sanaria.com
RI Bennett, Jason/B-3547-2011; Laurens, Matthew/E-7293-2013;
OI Laurens, Matthew/0000-0003-3874-581X; Richie, Thomas/0000-0002-2946-5456
FU Bill and Melinda Gates Foundation (BMGF); National Institute of Allergy
and Infectious Diseases-NIH [5R44AI055229-07, 5R44AI058499-05,
5R44AI058375-05]; Institute for OneWorld Health (BMGF); U.S. Military
Infectious Disease; Work Unit [6000.RAD1.F.A0309]; Howard Hughes Medical
Institute; Doris Duke Charitable Foundation
FX We thank the volunteers and the PfSPZ Vaccine Development Teams and NHP
team (see SOM) for their participation and efforts. The PATH Malaria
Vaccine Initiative (MVI) supported the clinical trial with funds from
the Bill and Melinda Gates Foundation (BMGF). Sanaria acknowledges
support from National Institute of Allergy and Infectious Diseases-NIH
Small Business Innovation Research grants, especially 5R44AI055229-07,
5R44AI058499-05, and 5R44AI058375-05; Institute for OneWorld Health
(funds from BMGF); and U.S. Military Infectious Disease Research
Program, which enabled development and manufacture of the vaccine. At
Naval Medical Research Center, work was funded by Work Unit Number
6000.RAD1.F.A0309. At UMD, PCR work was funded by the Howard Hughes
Medical Institute and Doris Duke Charitable Foundation. All of the data
reported in the manuscript are tabulated in the main text and in the
SOM. A materials transfer agreement will be required for the use of
recombinant PfMSP-1 and PfEBA-175 and for HC-04 cells. A number of
patents on PfSPZ have been issued, allowed, or filed in the United
States and internationally. The U.S. patents include S. L. Hoffman et
al., U.S. Patent 7,229,627 (2007) (there is a divisional of this patent
with claims directed to aseptic adult Anopheles-species mosquitoes and
aseptic Plasmodium-species sporozoites, USSN 11/726,622); S. L. Hoffman
et al., U.S. Patent Pub. US2005/0208078 (2005); and B. K. L. Sim, S. L.
Hoffman, M. Li, R. E. Stafford, U.S. Patent Pub U. S. 2010/0183680
(2010). There is also a patent on HC-04 cells [J. Prachumsri et al.,
U.S. Patent 7015036 (2006)].
NR 51
TC 179
Z9 181
U1 2
U2 42
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD OCT 28
PY 2011
VL 334
IS 6055
BP 475
EP 480
DI 10.1126/science.1211548
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 837UR
UT WOS:000296230500037
PM 21903775
ER
PT J
AU Lin, J
Sproul, WD
Moore, JJ
Wu, ZL
Lee, SL
AF Lin, J.
Sproul, W. D.
Moore, J. J.
Wu, Z. L.
Lee, S. L.
TI Effect of negative substrate bias voltage on the structure and
properties of CrN films deposited by modulated pulsed power (MPP)
magnetron sputtering
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
ID CHROMIUM NITRIDE COATINGS; UNBALANCED MAGNETRON; THIN-FILMS;
VAPOR-DEPOSITION; HARD COATINGS; STRESS; GROWTH; DC; TEMPERATURE;
EVAPORATION
AB As a variation of high power pulsed magnetron sputtering technique, modulated pulsed power (MPP) magnetron sputtering has shown the capability of maintaining a good deposition rate while achieving a high degree of ionization of the sputtered material with low ion energies. It is critical to usefully utilize the negative substrate bias voltage (V-b) to attract these ions towards the substrate to enhance the ion bombardment on growing films by controlling the kinetic energy and the behaviours of ions and electrons arriving on growing films. In this study, CrN thin films have been deposited by MPP in a closed field unbalanced magnetron sputtering system at different V-b varied from 0 to -150V. The peak and mean substrate ion current densities were measured during the depositions as a function of V-b. The films were annealed at 450 degrees C in Ar for 1 hr in an effort to release the defects and residual stress in the as-deposited films. The structure and properties of as-deposited and annealed films were characterized by electron probe micro-analysis, x-ray diffraction, scanning electron microscopy, transmission electron microscopy, nanoindentation, and ball-on-disc wear test. An increase in the Cr/N ratio of the film was observed as the V-b was increased negatively to above -70V, which resulted in the formation of the hexagonal Cr2N film at V-b = -150V. A preferred (3 1 1) texture was observed in the CrN films deposited as V-b increased from -50V to -100V. The residual stress of the films increased as the V-b was increased from 0 to -100V and then decreased with further increasing the V-b. The increase in the V-b led to grain refinement and an increase in the hardness of the films, but the wear resistance of the films decreased rapidly as the V-b was increased to -150V.
C1 [Lin, J.; Sproul, W. D.; Moore, J. J.; Wu, Z. L.] Colorado Sch Mines, ACSEL, Dept Met & Mat Engn, Golden, CO 80401 USA.
[Sproul, W. D.] React Sputtering Inc, San Marcos, CA 92078 USA.
[Lee, S. L.] USA, ARDEC Benet Labs, Watervliet, NY 12189 USA.
RP Lin, J (reprint author), Colorado Sch Mines, ACSEL, Dept Met & Mat Engn, Golden, CO 80401 USA.
EM jlin@mines.edu
RI Lin, Jianliang/F-8405-2012
FU US Army [W15QKN-08-P-0528]
FX Support of this research program from the US Army (Army Award#:
W15QKN-08-P-0528) is gratefully acknowledged.
NR 44
TC 14
Z9 14
U1 5
U2 28
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD OCT 26
PY 2011
VL 44
IS 42
AR 425305
DI 10.1088/0022-3727/44/42/425305
PG 11
WC Physics, Applied
SC Physics
GA 842IF
UT WOS:000296590300015
ER
PT J
AU Wu, TY
Beyer, FL
Brown, RH
Moore, RB
Long, TE
AF Wu, Tianyu
Beyer, Frederick L.
Brown, Rebecca H.
Moore, Robert B.
Long, Timothy E.
TI Influence of Zwitterions on Thermomechanical Properties and Morphology
of Acrylic Copolymers: Implications for Electroactive Applications
SO MACROMOLECULES
LA English
DT Article
ID X-RAY-SCATTERING; CORRESPONDING CATIONIC POLYMERS; N-BUTYL ACRYLATE;
AQUEOUS-SOLUTION PROPERTIES; MECHANICAL-PROPERTIES; BETAINE COPOLYMERS;
AMMONIUM IONENES; BULK PROPERTIES; IONOMERS; POLY(SULFOBETAINE)S
AB n-Butyl acrylate-based zwitterionomers and ionomers containing 3-[[2-(methacryloyloxy)ethyn(dimethypammonio]-1-propanesulfonate (SBMA) and 2-[butyl(dimethyl)amino]ethyl methacrylate methanesulfonate (BDMAEMA MS), respectively, were synthesized using conventional free radical polymerization. Size-exclusion chromatography confirmed the molecular weights of the copolymers exceeded the critical molecular weight between entanglements (Me) for poly(n-butyl acrylate). Differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS), and atomic force microscopy (AFM) revealed that zwitterionomers promoted more well-defined microphase separation than cationic analogues. Dynamic mechanical analyses (DMA) of the copolymers showed a rubbery plateau region due to physical cross-links between charges for zwitterionomers only. Since SBMA and BDMAEMA MS have very similar chemical structures, we attributed improved microphase separation and superior elastomeric performance of the zwitterionomers to stronger association between covalently tethered charged pairs.
C1 [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Wu, Tianyu; Brown, Rebecca H.; Moore, Robert B.; Long, Timothy E.] Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA.
RP Beyer, FL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM rick.beyer@us.army.mil; telong@vt.edu
RI Moore, Robert/E-9619-2011
OI Moore, Robert/0000-0001-9057-7695
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-07-1-0339]
FX This material is based upon work supported by the U.S. Army Research
Laboratory and the U.S. Army Research Office under Grant
W911NF-07-1-0339. Parts of this work were carried out using instruments
in the Nanoscale Characterization and Fabrication Laboratory, a Virginia
Tech facility operated by the Institute for Critical Technology and
Applied Science. The authors also acknowledge Dr. Andrew Duncan at the
U.S. Army Research Laboratory for his assistance with the collection of
small-angle X-ray scattering data.
NR 43
TC 16
Z9 17
U1 2
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
J9 MACROMOLECULES
JI Macromolecules
PD OCT 25
PY 2011
VL 44
IS 20
BP 8056
EP 8063
DI 10.1021/ma201211J
PG 8
WC Polymer Science
SC Polymer Science
GA 833TG
UT WOS:000295907200022
ER
PT J
AU Grujicic, M
Pandurangan, B
Bell, WC
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Pandurangan, B.
Bell, W. C.
Yen, C. -F.
Cheeseman, B. A.
TI Application of a dynamic-mixture shock-wave model to the metal-matrix
composite materials
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Structured shocks; Dynamic-mixture model; Metal-matrix composites
ID CRYSTAL PLASTICITY; DEFORMATION; ALUMINUM
AB The so-called "dynamic mixture" model is applied to a prototypical metal matrix composite (MMC) system (consisting of an aluminum matrix and SiC particulates) in order to investigate the propagation of planar (i.e. one directional), longitudinal (i.e. uniaxial strain), steady (i.e. time-invariant) structured shock waves. Waves of this type are typically generated during blast-wave loading or ballistic impact and play a major role in the way blast/ballistic impact loads are introduced into a structure. Hence, the knowledge of their propagation behavior is critical for designing structures with superior blast and impact protection capacities.
To validate the computational procedure used, the structured shock-wave analysis is first applied to a homogeneous (i.e. single component) metallic system (commercially pure niobium). Next, the analysis is applied to the aforementioned MMC (in the limit of intermediate to strong shocks) when the contribution of the stress deviator to the total stress state can be neglected. Finally, the computational results are compared with their experimental counterparts available in the open literature in order to validate the dynamic-mixture method used. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Grujicic, M.; Pandurangan, B.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory
(ARL) [W911NF-06-2-0042]
FX The material presented in this paper is based on work supported by the
Army Research Office (ARO) research contract entitled "Multi-length
Scale Material Model Development for Armor-grade Composites", Contract
Number W911NF-09-1-0513, and the Army Research Laboratory (ARL) research
contract entitled "Computational Analysis and Modeling of Various
Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil"
Contract Number W911NF-06-2-0042.
NR 19
TC 7
Z9 7
U1 1
U2 8
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD OCT 25
PY 2011
VL 528
IS 28
BP 8187
EP 8197
DI 10.1016/j.msea.2011.08.008
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 829DE
UT WOS:000295555500020
ER
PT J
AU Tchonkova, M
Peters, J
Sture, S
AF Tchonkova, Maria
Peters, John
Sture, Stein
TI Three-dimensional modeling of problems in poro-elasticity via a mixed
least-squares method using linear tetrahedral elements
SO INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN
GEOMECHANICS
LA English
DT Article
DE poro-elsticity; Darcy flow; mixed finite
ID SOLVING PROBLEMS
AB In a previous publication we developed a new mixed least-squares method for poro-elasticity. The approximate solution was obtained via a minimization of a least-squares functional, based upon the equations of equilibrium, the equations of continuity and weak forms of the constitutive relationships for elasticity and Darcy flow. The formulation involved four independent types of variables: displacements, stresses, pore pressures and velocities. All of them were approximated by linear continuous triangles. Encouraged by the computational results, obtained from the two-dimensional implementation of the method, we extended our formulation to three dimensions. In this paper we present numerical examples for the performance of continuous linear tetrahedra within the context of the mixed least-squares method. The initial results suggest that the method works well in the nearly and entirely incompressible limits for elasticity. For poro-elasticity, the obtained pore pressures are stable without exhibiting the oscillations, which are observed when the standard Galerkin formulation is used. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Peters, John] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39190 USA.
[Sture, Stein] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA.
RP Tchonkova, M (reprint author), 9009 Great Hills Trail,Suite 224, Austin, TX 78759 USA.
EM maria.tchonkova@att.net
FU Institute for Maneuverability and Terrain Physics Simulation (IMTPS) at
the US Army Engineer Research and Development Center (ERDC); Department
of Defense High Performance Computing System [W912HZ-07-C-0025]
FX This work was supported by the Institute for Maneuverability and Terrain
Physics Simulation (IMTPS) at the US Army Engineer Research and
Development Center (ERDC), which was funded by the Department of Defense
High Performance Computing System under contract W912HZ-07-C-0025.
NR 6
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0363-9061
J9 INT J NUMER ANAL MET
JI Int. J. Numer. Anal. Methods Geomech.
PD OCT 25
PY 2011
VL 35
IS 15
BP 1656
EP 1681
DI 10.1002/nag.971
PG 26
WC Engineering, Geological; Materials Science, Multidisciplinary; Mechanics
SC Engineering; Materials Science; Mechanics
GA 824TR
UT WOS:000295225600003
ER
PT J
AU Marek, P
Senecal, K
Nida, D
Magnone, J
Senecal, A
AF Marek, Patrick
Senecal, Kris
Nida, Dawn
Magnone, Joshua
Senecal, Andre
TI Application of a biotin functionalized QD assay for determining
available binding sites on electrospun nanofiber membrane
SO JOURNAL OF NANOBIOTECHNOLOGY
LA English
DT Article
ID QUANTUM DOTS
AB Background: The quantification of surface groups attached to non-woven fibers is an important step in developing nanofiber biosensing detection technologies. A method utilizing biotin functionalized quantum dots (QDs) 655 for quantitative analysis of available biotin binding sites within avidin immobilized on electrospun nanofiber membranes was developed.
Results: A method for quantifying nanofiber bound avidin using biotin functionalized QDs is presented. Avidin was covalently bound to electrospun fibrous polyvinyl chloride (PVC 1.8% COOH w/w containing 10% w/w carbon black) membranes using primary amine reactive EDC-Sulfo NHS linkage chemistry. After a 12 h exposure of the avidin coated membranes to the biotin-QD complex, fluorescence intensity was measured and the total amount of attached QDs was determined from a standard curve of QD in solution (total fluorescence vs. femtomole of QD 655). Additionally, fluorescence confocal microscopy verified the labeling of avidin coated nanofibers with QDs. The developed method was tested against 2.4, 5.2, 7.3 and 13.7 mg spray weights of electrospun nanofiber mats. Of the spray weight samples tested, maximum fluorescence was measured for a weight of 7.3 mg, not at the highest weight of 13.7 mg. The data of total fluorescence from QDs bound to immobilized avidin on increasing weights of nanofiber membrane was best fit with a second order polynomial equation (R(2) = .9973) while the standard curve of total fluorescence vs. femtomole QDs in solution had a linear response (R(2) = .999).
Conclusion: A QD assay was developed in this study that provides a direct method for quantifying ligand attachment sites of avidin covalently bound to surfaces. The strong fluorescence signal that is a fundamental characteristic of QDs allows for the measurement of small changes in the amount of these particles in solution or attached to surfaces.
C1 [Marek, Patrick; Nida, Dawn; Magnone, Joshua; Senecal, Andre] USA, Food Safety & Def Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Senecal, Kris] USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Marek, P (reprint author), USA, Food Safety & Def Team, Natick Soldier Res Dev & Engn Ctr, 15 Kansas St, Natick, MA 01760 USA.
EM Patrick.Marek@us.army.mil
RI Senecal, Kris/F-3000-2013
FU DoD Joint Service
FX This work was directly funded under the DoD Joint Service Combat Feeding
Technology Program.
NR 19
TC 1
Z9 1
U1 2
U2 30
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-3155
J9 J NANOBIOTECHNOL
JI J. Nanobiotechnol.
PD OCT 24
PY 2011
VL 9
AR 48
DI 10.1186/1477-3155-9-48
PG 7
WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
SC Biotechnology & Applied Microbiology; Science & Technology - Other
Topics
GA 849MZ
UT WOS:000297130900001
PM 22024374
ER
PT J
AU Cope, EC
Morris, DR
Scrimgeour, AG
VanLandingham, JW
Levenson, CW
AF Cope, Elise C.
Morris, Deborah R.
Scrimgeour, Angus G.
VanLandingham, Jacob W.
Levenson, Cathy W.
TI Zinc supplementation provides behavioral resiliency in a rat model of
traumatic brain injury
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Zinc; TBI; Depression; Anxiety; Anhedonia; Spatial memory
ID LOWER SERUM ZINC; MAJOR DEPRESSION; DEFICIENCY; CHELATION; MEMORY
AB Depression, anxiety, and impairments in learning and memory are all associated with traumatic brain injury (TBI). Because of the strong link between zinc deficiency, depression, and anxiety, in both humans and rodent models, we hypothesized that dietary zinc supplementation prior to injury could provide behavioral resiliency to lessen the severity of these outcomes after TBI. Rats were fed a marginal zinc deficient (5 ppm), zinc adequate (30 ppm), or zinc supplemented (180 ppm) diet for 4 weeks followed by a moderately-severe TBI using the well-established model of controlled cortical impact (CCI). Following CCI, rats displayed depression-like behaviors as measured by the 2-bottle saccharin preference test for anhedonia. Injury also resulted in evidence of stress and impairments in Morris water maze (MWM) performance compared to sham-injured controls. While moderate zinc deficiency did not worsen outcomes following TBI, rats that were fed the zinc supplemented diet for 4 weeks showed significantly attenuated increases in adrenal weight (p < 0.05) as well as reduced depression-like behaviors (p < 0.001). Supplementation prior to injury improved resilience such that there was not only significant improvements in cognitive behavior compared to injured rats fed an adequate diet (p < 0.01), there were no significant differences between supplemented and sham-operated rats in MWM performance at any point in the 10-day trial. These data suggest a role for supplemental zinc in preventing cognitive and behavioral deficits associated with TBI. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Cope, Elise C.; Morris, Deborah R.; VanLandingham, Jacob W.; Levenson, Cathy W.] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
[VanLandingham, Jacob W.; Levenson, Cathy W.] Florida State Univ, Coll Med, Program Neurosci, Tallahassee, FL 32306 USA.
[Scrimgeour, Angus G.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA.
RP Levenson, CW (reprint author), Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
EM cathy.levenson@med.fsu.edu
FU U.S. Army Medical Research and Material Command
FX The authors would like to thank Dr. Vincent Salters at the National High
Magnetic Field Laboratory (Tallahassee, FL) for his assistance with the
brain zinc measurements, Shannon Gower-Winter, MS for excellent
technical and editorial assistance, and the U.S. Army Medical Research
and Material Command who funded this work.
NR 25
TC 20
Z9 23
U1 4
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 24
PY 2011
VL 104
IS 5
BP 942
EP 947
DI 10.1016/j.physbeh.2011.06.007
PG 6
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 837MP
UT WOS:000296208200040
PM 21699908
ER
PT J
AU Avalos, E
Sun, DK
Doney, RL
Sen, S
AF Avalos, Edgar
Sun, Diankang
Doney, Robert L.
Sen, Surajit
TI Sustained strong fluctuations in a nonlinear chain at acoustic vacuum:
Beyond equilibrium
SO PHYSICAL REVIEW E
LA English
DT Article
ID EXACTLY SOLVABLE MODEL; FOKKER-PLANCK EQUATION; PASTA-ULAM MODEL;
BROWNIAN-MOTION; SOLITARY WAVES; HERTZIAN CHAINS; ENERGY LOCALIZATION;
LANGEVIN EQUATION; GRANULAR COLUMNS; PROPAGATION
AB Here we consider dynamical problems as in linear response theory but for purely nonlinear systems where acoustic propagation is prohibited by the potential, e.g., the case of an alignment of elastic grains confined between walls. Our simulations suggest that in the absence of acoustic propagation, the system relaxes using only solitary waves and the eventual state does not resemble an equilibrium state. Further, the studies reveal that multiple perturbations could give rise to hot and cold spots in these systems. We first use particle dynamics based simulations to understand how one of the two unequal colliding solitary waves in the chain can gain energy. Specifically, we find that for head-on collisions the smaller wave gains energy, whereas when a more energetic wave overtakes a less energetic wave, the latter gains energy. The balance between the rate at which the solitary waves break down and the rate at which they grow eventually makes it possible for the system to reach a peculiar equilibriumlike phase that is characteristic of these purely nonlinear systems. The study of the features and the robustness of the fluctuations in time has been addressed next. A particular characteristic of this equilibriumlike or quasiequilibrium phase is that very large energy fluctuations are possible-and by very large, we mean that the energy can vary between zero and several times the average energy per grain. We argue that the magnitude of the fluctuations depend on the nature of the nonlinearity in the potential energy function and the feature that any energy must eventually travel as a compact solitary wave in these systems where the solitary wave energies may vary widely. In closing we address whether these fluctuations are peculiar to one dimension or can exist in higher dimensions. The study hence raises the following intriguing possibility. Are there physical or biological systems where these kinds of nonlinear forces exist, and if so, can such large fluctuations actually be seen? Implications of the study are briefly discussed.
C1 [Avalos, Edgar] Chung Yuan Christian Univ, Dept Phys, Chungli 32063, Taiwan.
[Sun, Diankang] New Mexico Resonance, Albuquerque, NM 87106 USA.
[Doney, Robert L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Sen, Surajit] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA.
RP Avalos, E (reprint author), Chung Yuan Christian Univ, Dept Phys, Chungli 32063, Taiwan.
FU US Army Research Office
FX This work has been supported by the US Army Research Office.
NR 83
TC 7
Z9 7
U1 0
U2 6
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD OCT 21
PY 2011
VL 84
IS 4
AR 046610
DI 10.1103/PhysRevE.84.046610
PN 2
PG 8
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA 841QX
UT WOS:000296528700009
PM 22181299
ER
PT J
AU Li, Y
Gong, P
Perkins, EJ
Zhang, CY
Wang, N
AF Li, Ying
Gong, Ping
Perkins, Edward J.
Zhang, Chaoyang
Wang, Nan
TI RefNetBuilder: a platform for construction of integrated reference gene
regulatory networks from expressed sequence tags
SO BMC BIOINFORMATICS
LA English
DT Article; Proceedings Paper
CT 8th Annual Conference of the
MidSouth-Computational-Biology-and-Bioinformatics-Society (MCBIOS)
CY APR 01-02, 2011
CL Coll Stn, TX
SP MidSouth Computat Biol & Bioinformat Soc (MCBIOS)
ID BIOLOGICAL NETWORKS; PATHWAY; RECONSTRUCTION; ANNOTATION; DATABASE;
KEGG; WEB
AB Background: Gene Regulatory Networks (GRNs) provide integrated views of gene interactions that control biological processes. Many public databases contain biological interactions extracted from experimentally validated literature reports, but most furnish only information for a few genetic model organisms. In order to provide a bioinformatic tool for researchers who work with non-model organisms, we developed RefNetBuilder, a new platform that allows construction of putative reference pathways or GRNs from expressed sequence tags (ESTs).
Results: RefNetBuilder was designed to have the flexibility to extract and archive pathway or GRN information from public databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG). It features sequence alignment tools such as BLAST to allow mapping ESTs to pathways and GRNs in model organisms. A scoring algorithm was incorporated to rank and select the best match for each query EST. We validated RefNetBuilder using DNA sequences of Caenorhabditis elegans, a model organism having manually curated KEGG pathways. Using the earthworm Eisenia fetida as an example, we demonstrated the functionalities and features of RefNetBuilder.
Conclusions: The RefNetBuilder provides a standalone application for building reference GRNs for non-model organisms on a number of operating system platforms with standard desktop computer hardware. As a new bioinformatic tool aimed for constructing putative GRNs for non-model organisms that have only ESTs available, RefNetBuilder is especially useful to explore pathway-or network-related information in these organisms.
C1 [Gong, Ping] SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA.
[Li, Ying; Zhang, Chaoyang; Wang, Nan] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA.
[Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Gong, P (reprint author), SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA.
EM ping.gong@usace.army.mil; nan.wang@usm.edu
NR 23
TC 4
Z9 4
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD OCT 18
PY 2011
VL 12
SU 10
AR S20
DI 10.1186/1471-2105-12-S10-S20
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA 941AG
UT WOS:000303933600020
PM 22166047
ER
PT J
AU Mayo, ML
Perkins, EJ
Ghosh, P
AF Mayo, Michael L.
Perkins, Edward J.
Ghosh, Preetam
TI First-passage time analysis of a one-dimensional diffusion-reaction
model: application to protein transport along DNA
SO BMC BIOINFORMATICS
LA English
DT Article; Proceedings Paper
CT 8th Annual Conference of the
MidSouth-Computational-Biology-and-Bioinformatics-Society (MCBIOS)
CY APR 01-02, 2011
CL Coll Stn, TX
SP MidSouth Computat Biol & Bioinformat Soc (MCBIOS)
ID REPRESSOR-OPERATOR INTERACTION; FACILITATED TARGET LOCATION; DRIVEN
MECHANISMS; NUCLEIC-ACIDS; REGULATORY PROTEINS; TRANSLOCATION; KINETICS;
EQUILIBRIUM; BINDING; LENGTH
AB Background: Proteins search along the DNA for targets, such as transcription initiation sequences, according to one-dimensional diffusion, which is interrupted by micro-and macro-hopping events and intersegmental transfers that occur under close packing conditions.
Results: A one-dimensional diffusion-reaction model in the form of difference-differential equations is proposed to analyze the nonequilibrium protein sliding kinetics along a segment of bacterial DNA. A renormalization approach is used to derive an expression for the mean first-passage time to arrive at sites downstream of the origin from the occupation probabilities given by the individual transport equations. Monte Carlo simulations are employed to assess the validity of the proposed approach, and all results are interpreted within the context of bacterial transcription.
Conclusions: Mean first-passage times decrease with increasing reaction rates, indicating that, on average, surviving proteins more rapidly locate downstream targets than their reaction-free counterparts, but at the price of increasing rarity. Two qualitatively different screening regimes are identified according to whether the search process operates under "small" or "large" values for the dissociation rate of the protein-DNA complex. Lower bounds are placed on the overall search time for varying reactive conditions. Good agreement with experimental estimates requires the reaction rate reside near the transition between both screening regimes, suggesting that biology balances a need for rapid searches against maximum exploration during each round of the sliding phase.
C1 [Mayo, Michael L.; Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA 23284 USA.
RP Mayo, ML (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Michael.L.Mayo@usace.army.mil
NR 30
TC 3
Z9 3
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD OCT 18
PY 2011
VL 12
SU 10
AR S18
DI 10.1186/1471-2105-12-S10-S18
PG 14
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA 941AG
UT WOS:000303933600018
PM 22165905
ER
PT J
AU Wren, JD
Kupfer, DM
Perkins, EJ
Bridges, S
Winters-Hilt, S
Dozmorov, MG
Braga-Neto, U
AF Wren, Jonathan D.
Kupfer, Doris M.
Perkins, Edward J.
Bridges, Susan
Winters-Hilt, Stephen
Dozmorov, Mikhail G.
Braga-Neto, Ulisses
TI Proceedings of the 2011 MidSouth Computational Biology and
Bioinformatics Society (MCBIOS) Conference INTRODUCTION
SO BMC BIOINFORMATICS
LA English
DT Editorial Material
ID EXPRESSION DATA; NETWORKS; GENOMICS; TOOL; IDENTIFICATION; MICROARRAYS;
ANNOTATION; DYNAMICS; DATABASE; VIRUSES
C1 [Wren, Jonathan D.; Dozmorov, Mikhail G.] Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, Oklahoma City, OK 73104 USA.
[Kupfer, Doris M.] FAA, Aerosp Med Inst, Oklahoma City, OK 73169 USA.
[Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Bridges, Susan] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA.
[Winters-Hilt, Stephen] Univ New Orleans, Computer Sci Dept, New Orleans, LA 70148 USA.
[Braga-Neto, Ulisses] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
RP Wren, JD (reprint author), Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
EM jdwren@gmail.com
RI Wren, Jonathan/E-5611-2011; Dozmorov, Mikhail/B-1374-2009
OI Wren, Jonathan/0000-0003-2776-3545; Dozmorov,
Mikhail/0000-0002-0086-8358
FU FDA HHS [1R13FD004229-01]
NR 51
TC 0
Z9 0
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD OCT 18
PY 2011
VL 12
SU 10
AR S1
DI 10.1186/1471-2105-12-S10-S1
PG 5
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA 941AG
UT WOS:000303933600001
PM 22165918
ER
PT J
AU Bressanini, D
Reynolds, PJ
AF Bressanini, Dario
Reynolds, Peter J.
TI Generalized variational principle for excited states using nodes of
trial functions
SO PHYSICAL REVIEW E
LA English
DT Article
ID HELIUM
AB The familiar variational principle provides an upper bound to the ground-state energy of a given Hamiltonian. This allows one to optimize a trial wave function by minimizing the expectation value of the energy. This approach is also trivially generalized to excited states, so that given a trial wave function of a certain symmetry, one can compute an upper bound to the lowest-energy level of that symmetry. In order to generalize further and build an upper bound of an arbitrary excited state of the desired symmetry, a linear combination of basis functions is generally used to generate an orthogonal set of trial functions, all bounding their respective states. However, sometimes a compact wave-function form is sought, and a basis-set expansion is not desirable or possible. Here we present an alternative generalization of the variational principle to excited states that does not require explicit orthogonalization to lower-energy states. It is valid for one-dimensional systems and, with additional information, to at least some n-dimensional systems. This generalized variational principle exploits information about the nodal structure of the trial wave function, giving an upper bound to the exact energy without the need to build a linear combination of basis functions. To illustrate the theorem we apply it to a nontrivial example: the 1s2s (1)S excited state of the helium atom.
C1 [Bressanini, Dario] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy.
[Reynolds, Peter J.] USA, Div Phys, Res Off, Res Triangle Pk, NC 27709 USA.
RP Bressanini, D (reprint author), Univ Insubria, Dipartimento Sci Chim & Ambientali, Via Lucini 3, I-22100 Como, Italy.
EM dario.bressanini@uninsubria.it; peter.reynolds@us.army.mil
NR 12
TC 1
Z9 1
U1 0
U2 4
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1539-3755
J9 PHYS REV E
JI Phys. Rev. E
PD OCT 18
PY 2011
VL 84
IS 4
AR 046705
DI 10.1103/PhysRevE.84.046705
PN 2
PG 4
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA 841PT
UT WOS:000296525500008
PM 22181305
ER
PT J
AU Klein, RJ
Fischer, DA
Lenhart, JL
AF Klein, Robert J.
Fischer, Daniel A.
Lenhart, Joseph L.
TI Thermal and Mechanical Aging of Self-Assembled Monolayers as Studied by
Near Edge X-ray Absorption Fine Structure
SO LANGMUIR
LA English
DT Article
ID MOLECULAR-ORIENTATION; SURFACE-CHEMISTRY; VAPOR-DEPOSITION;
CONTACT-ANGLE; MEMS; FILMS; SPECTROSCOPY; SYSTEMS; NEXAFS; DEGRADATION
AB Self-assembled monolayers (SAMs) enable significant changes in the surface energy and/or specific interactions of surfaces, which are desirable for microelectromechanical systems (MEMS), superhydrophobic coatings, sensors, and other applications. However, SAMs often exhibit poor durability and rapid degradation upon mechanical, thermal, or moisture exposure. The chemical and orientational changes in SAMs due to mechanical and thermal degradation were investigated using near-edge X-ray absorption fine structure (NEXAFS) and the water contact angle. SAMs were based on unfluorinated or fluorinated linear hydrocarbons that form highly oriented and densely packed structures on silicon substrates. Complex chemical and orientational changes were observed via NEXAFS following degradation. Under heating in a dry, oxygen-rich environment, unfluorinated SAMs tended to cleave at C-C bonds on the main chain; below 250 degrees C, CH(3) groups were sequentially cleaved toward the surface, whereas above 250 degrees C, remaining hydrocarbon groups were converted to a graphitic coating dominated by C=C bonds. Under similar conditions, fluorinated SAMs began their chemical degradation at 350 degrees C and above, although the orientation decreased steadily from 150 to 300 degrees C; at and above 350 degrees C, the preferential removal of F occurred and the SAM was slowly converted to a graphitic layer. By contrast, under vacuum the fluorinated molecules were very thermally stable, showing good stability up to 550 degrees C; when degradation occurred, entire molecules were removed. Mechanical degradation followed two routes; both unfluorinated and fluorinated SAMs that were mechanically rubbed with smooth surfaces exhibited severe chemical degradation of the molecules, leading to an amorphous and poorly defined layer with C=C, C-C, C-H, and C-F bonds. Unfluorinated and fluorinated surfaces that were mechanically rubbed in the presence of free silicon particulates showed the rapid and complete destruction of both the molecular orientation and the protective SAM layer, even for short exposure periods. The resulting NEXAFS spectra were very similar to those produced by heating to 550 degrees C, suggesting that the friction created by granular particles may lead to extreme local heating.
C1 [Klein, Robert J.] Luna Innovat Inc, Mat Syst Grp, Charlottesville, VA USA.
[Klein, Robert J.; Lenhart, Joseph L.] Sandia Natl Labs, Organ Mat Dept, Albuquerque, NM 87185 USA.
[Fischer, Daniel A.] Natl Inst Stand & Technol, Mat Sci & Engn Lab, Gaithersburg, MD 20899 USA.
[Lenhart, Joseph L.] USA, Res Lab, Weap & Mat Res Directorate, Mat & Mfg Sci Div,Macromol Sci & Technol Branch, Aberdeen, MD USA.
RP Klein, RJ (reprint author), Luna Innovat Inc, Mat Syst Grp, Charlottesville, VA USA.
EM kleinr@lunainnovations.com; joseph.l.lenhart.civ@mail.mil
FU Sandia Corporation, a Lockheed Martin Company, for the United States
Department of Energy's National Nuclear Security Administration
[DE-AC04-94AL85000]
FX This work was initiated by R.J.K. and J.L.L. at Sandia National
Laboratories, Albuquerque, New Mexico, and is being continued by J.L.L.
at the U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland.
Sandia is a multiprogram laboratory operated by Sandia Corporation, a
Lockheed Martin Company, for the United States Department of Energy's
National Nuclear Security Administration under contract
DE-AC04-94AL85000. Special thanks to Chem Jaye for assistance with the
NEXAFS instrumentation at Brookhaven and Mike Dugger at Sandia for
discussions regarding MEMS antistiction coatings.
NR 52
TC 9
Z9 9
U1 3
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD OCT 18
PY 2011
VL 27
IS 20
BP 12423
EP 12433
DI 10.1021/la202294f
PG 11
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 830OD
UT WOS:000295665400024
PM 21863831
ER
PT J
AU O'Regan, TP
Hurley, PK
AF O'Regan, T. P.
Hurley, P. K.
TI Calculation of the capacitance-voltage characteristic of GaAs,
In0.53Ga0.47As, and InAs metal-oxide-semiconductor structures
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID TRANSPORT; SILICON; MOSFETS
AB The capacitance-voltage characteristic of GaAs, In0.53Ga0.47As, and InAs metal-oxide-semiconductor capacitors (MOSCAPs) is calculated in three cases. First, quantization is not considered, then quantization of the C-valley is included, and finally quantization of the Gamma-, X-, and L-valleys is included. The choice of valley energy-minima is shown to determine the onset of occupation of the satellite valleys and corresponding increase in total capacitance. An equivalent-oxide-thickness correction is defined and used as a figure-of-merit to compare III-V to Si MOSCAPs and as a metric for the density-of-states bottleneck. (C) 2011 American Institute of Physics. [doi:10.1063/1.3652699]
C1 [O'Regan, T. P.; Hurley, P. K.] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Lee Maltings, Prospect Row Co, Ireland.
[O'Regan, T. P.] USA, Res Lab, RDRL SER E, Adelphi, MD 20783 USA.
RP O'Regan, TP (reprint author), Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Lee Maltings, Prospect Row Co, Ireland.
EM terrance.p.oregan.ctr@us.army.mil
FU Science Foundation Ireland through the U.S.-Ireland [08/US/I1546]; U.S.
Army Research Laboratory
FX This work was supported by Science Foundation Ireland through the
U.S.-Ireland Research Project (08/US/I1546). T. P. O'Regan also
recognizes support from the U.S. Army Research Laboratory. We thank
Massimo Fischetti and Quentin Rafhay for useful discussions.
NR 17
TC 7
Z9 7
U1 0
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD OCT 17
PY 2011
VL 99
IS 16
AR 163502
DI 10.1063/1.3652699
PG 3
WC Physics, Applied
SC Physics
GA 841MY
UT WOS:000296517600078
ER
PT J
AU Collier, ZA
Vogel, JT
Zemba, SG
Ferguson, EA
Linkov, I
AF Collier, Zachary A.
Vogel, John T.
Zemba, Stephen G.
Ferguson, Elizabeth A.
Linkov, Igor
TI Management Tools for Managing Vapor Intrusion
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Editorial Material
C1 [Collier, Zachary A.; Vogel, John T.; Ferguson, Elizabeth A.; Linkov, Igor] USA, Corps Engineers, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Zemba, Stephen G.] Cambridge Environm Inc, Cambridge, MA 02141 USA.
RP Linkov, I (reprint author), 696 Virginia Rd, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
NR 5
TC 1
Z9 1
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 15
PY 2011
VL 45
IS 20
BP 8611
EP 8612
DI 10.1021/es203179w
PG 2
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 831BU
UT WOS:000295704500005
PM 21955030
ER
PT J
AU Chantawansri, TL
Duncan, AJ
Ilavsky, J
Stokes, KK
Berg, MC
Mrozek, RA
Lenhart, JL
Beyer, FL
Andzelm, JW
AF Chantawansri, Tanya L.
Duncan, Andrew J.
Ilavsky, Jan
Stokes, Kristoffer K.
Berg, Michael C.
Mrozek, Randy A.
Lenhart, Joseph L.
Beyer, Frederick L.
Andzelm, Jan W.
TI Phase Behavior of SEBS Triblock Copolymer Gels
SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
LA English
DT Article
DE block copolymers; gels; phase behavior; phase diagrams
ID THERMOPLASTIC ELASTOMER GELS; MICROPHASE SEPARATION TRANSITION;
ORDER-DISORDER TRANSITION; ANGLE X-RAY; BLOCK-COPOLYMER;
MOLECULAR-WEIGHT; POLYMER GELS; DIBLOCK COPOLYMERS; PROCESSING
CONDITIONS; MECHANICAL-PROPERTIES
AB Dynamic density functional theory calculations were performed for thermoplastic elastomer gels composed of an ABA triblock copolymer immersed in a B-attractive solvent. The triblock copolymer model was parameterized for poly[styrene-b-(ethylene-co-butylene)-b-styrene] (SEBS), while the solvent model was parameterized for the hydrocarbon oil tetradecane. The effect of the solvent concentration and S-EB interaction on the morphology was investigated, where complementary experimental data was used to validate results at chiABN approximate to 100. Agreement was observed at solvent volume fractions of 0.2, 0.4, and 0.6, which correspond to the cylindrical, spherical, and spherical phases, respectively. Qualitative agreement was observed for 0.8 volume fraction solvent, where a core-shell spherical micelle morphology was found. For a 50/50 vol % mixture of polymer/solvent, the effect of solvent molecular weight on the morphology was considered, where a transition between micro and macrophase separation was predicted at a critical solvent molecular weight. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 1479-1491, 2011
C1 [Chantawansri, Tanya L.; Duncan, Andrew J.; Stokes, Kristoffer K.; Berg, Michael C.; Mrozek, Randy A.; Lenhart, Joseph L.; Beyer, Frederick L.; Andzelm, Jan W.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
[Ilavsky, Jan] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA.
RP Andzelm, JW (reprint author), USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
EM jan.w.andzelm.civ@mail.mil
RI Ilavsky, Jan/D-4521-2013; Chantawansri, Tanya/N-3601-2013; USAXS,
APS/D-4198-2013
OI Ilavsky, Jan/0000-0003-1982-8900;
FU U.S. Army Research Laboratory; U.S. Department of Energy; USARL;
National Science Foundation/Department of Energy [NSF/CHE-0822838]; U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
[DE-AC02-06CH11357]
FX Two of the authors (TLC and AJD) were supported in part by an
appointment to the Postgraduate Research Participation Program at the
U.S. Army Research Laboratory administered by the Oak Ridge Institute
for Science and Education through an inter-agency agreement between the
U.S. Department of Energy and USARL. Calculations were performed on DOD
High Performance Computing site at the ARL. ChemMatCARS Sector 15 is
principally supported by the National Science Foundation/Department of
Energy under grant number NSF/CHE-0822838. Use of the Advanced Photon
Source was supported by the U.S. Department of Energy, Office of
Science, Office of Basic Energy Sciences, under Contract No.
DE-AC02-06CH11357. The authors would like to thank Drs. A. Schoch, P.
Chung, and B. Henz for useful discussion.
NR 100
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U1 0
U2 30
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0887-6266
J9 J POLYM SCI POL PHYS
JI J. Polym. Sci. Pt. B-Polym. Phys.
PD OCT 15
PY 2011
VL 49
IS 20
BP 1479
EP 1491
DI 10.1002/polb.22335
PG 13
WC Polymer Science
SC Polymer Science
GA 831FP
UT WOS:000295714400008
ER
PT J
AU Burgess, EB
AF Burgess, Edwin B.
TI Gallipoli
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD OCT 15
PY 2011
VL 136
IS 17
BP 92
EP 93
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA 833CU
UT WOS:000295860200161
ER
PT J
AU Ayyub, OB
Sekowski, JW
Yang, TI
Zhang, X
Briber, RM
Kofinas, P
AF Ayyub, Omar B.
Sekowski, Jennifer W.
Yang, Ta-I
Zhang, Xin
Briber, Robert M.
Kofinas, Peter
TI Color changing block copolymer films for chemical sensing of simple
sugars
SO BIOSENSORS & BIOELECTRONICS
LA English
DT Article
DE Color changing; Block copolymer; Sugar
ID PHOTONIC CRYSTALS; IONIC-STRENGTH; SENSORS; SILICON
AB We investigated the use of functionalized photonic block copolymer films for the detection of glucose. Polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) block copolymers were chemically functionalized with 2-(bromomethyl)phenylboronic acid and cast into films that reflect a visible color when exposed to aqueous media. The 2-(bromomethyl)phenylboronic acid functionality can reversibly bind to glucose. When exposed to high concentrations of glucose the polymer responded with a red shift in color. Low concentration exposure of glucose caused the polymer films to blue shift in color. The BCP films also exhibited a selective response to fructose, mannose or galactose, giving a different response depending on which sugar is present. The color of the polymer was tuned to blue, green, yellow or orange by varying the film's crosslink density. The color change can be visually observed without the use of equipment such as a spectrometer. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Ayyub, Omar B.; Yang, Ta-I; Kofinas, Peter] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
[Sekowski, Jennifer W.] USA, Edgewood Chem Biol Ctr, RDCB DRB C, Aberdeen Proving Ground, MD 21010 USA.
[Zhang, Xin; Briber, Robert M.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20740 USA.
RP Kofinas, P (reprint author), Univ Maryland, Fischell Dept Bioengn, 1120 Jeong H Kim Engn Bldg 225, College Pk, MD 20742 USA.
EM kofinas@umd.edu
RI Zhang, Xin/G-7362-2011; Fan, Yin/G-2594-2011; Briber,
Robert/A-3588-2012; Kofinas, Peter/A-8204-2012
OI Briber, Robert/0000-0002-8358-5942; Sekowski,
Jennifer/0000-0003-4561-640X; Kofinas, Peter/0000-0001-6657-3037
FU National Science Foundation [CBET0947771]; US Army ECBC; Maryland
NanoCenter; Maryland NispLab; NSF
FX This material is based on work supported by the National Science
Foundation grant no. CBET0947771 and by US Army ECBC ILIR Program. We
also acknowledge the support of the Maryland NanoCenter and its NispLab.
The NispLab is supported in part by the NSF as a MRSEC shared
experimental facility.
NR 15
TC 11
Z9 11
U1 1
U2 27
PU ELSEVIER ADVANCED TECHNOLOGY
PI OXFORD
PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON,
OXFORD OX5 1GB, OXON, ENGLAND
SN 0956-5663
J9 BIOSENS BIOELECTRON
JI Biosens. Bioelectron.
PD OCT 15
PY 2011
VL 28
IS 1
BP 349
EP 354
DI 10.1016/j.bios.2011.07.043
PG 6
WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical;
Electrochemistry; Nanoscience & Nanotechnology
SC Biophysics; Biotechnology & Applied Microbiology; Chemistry;
Electrochemistry; Science & Technology - Other Topics
GA 830MS
UT WOS:000295661700054
PM 21820888
ER
PT J
AU Bartolucci, SF
Paras, J
Rafiee, MA
Rafiee, J
Lee, S
Kapoor, D
Koratkar, N
AF Bartolucci, Stephen F.
Paras, Joseph
Rafiee, Mohammad A.
Rafiee, Javad
Lee, Sabrina
Kapoor, Deepak
Koratkar, Nikhil
TI Graphene-aluminum nanocomposites
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Graphene; Carbon nanotubes; Metal-matrix composite; Mechanical
properties; Powder processing
ID WALLED CARBON NANOTUBES; COMPOSITES; GRAPHITE; FATIGUE; OXIDE
AB Composites of graphene platelets and powdered aluminum were made using ball milling, hot isostatic pressing and extrusion. The mechanical properties and microstructure were studied using hardness and tensile tests, as well as electron microscopy, X-ray diffraction and differential scanning calorimetry. Compared to the pure aluminum and multi-walled carbon nanotube composites, the graphene-aluminum composite showed decreased strength and hardness. This is explained in the context of enhanced aluminum carbide formation with the graphene filler. Published by Elsevier B.V.
C1 [Bartolucci, Stephen F.; Paras, Joseph; Lee, Sabrina; Kapoor, Deepak] USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA.
[Rafiee, Mohammad A.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA.
[Rafiee, Javad; Koratkar, Nikhil] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA.
RP Bartolucci, SF (reprint author), USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA.
EM stephen.bartolucci@us.army.mil; koratn@rpi.edu
NR 19
TC 94
Z9 100
U1 19
U2 119
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD OCT 15
PY 2011
VL 528
IS 27
BP 7933
EP 7937
DI 10.1016/j.msea.2011.07.043
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 823FI
UT WOS:000295107500013
ER
PT J
AU Allen, JL
Jow, TR
Wolfenstine, J
AF Allen, J. L.
Jow, T. R.
Wolfenstine, J.
TI Improved cycle life of Fe-substituted LiCoPO4
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Li-ion battery; High voltage; XRD; Mossbauer; Cathode; LiCoPO4
ID DISCHARGE CAPACITY; LITHIUM BATTERIES; CATHODES; OLIVINES
AB Fe-substituted LiCoPO4 exhibits greatly improved cycle life relative to LiCoPO4. Whereas, pure LiCoPO4 loses more than half of its discharge capacity at the 10th cycle, the Fe-substituted LiCoPO4 retains about 100% of its discharge capacity at the 10th cycle and about 80% of its capacity at the 500th cycle. It is suggested that improved cycle life results from Fe3+ substitution on the Li and Co sites. The partial substitution of Li+ by Fe3+ and Co2+ by Fe2+ and Fe3+ was evidenced from Rietveld analysis of X-ray powder diffraction data, infrared spectroscopy, X-ray photoelectron spectroscopy and Mossbauer spectroscopy. The majority of the Fe3+ substitutes at the Co2+ site. The composition of Fe-substituted LiCoPO4 is Li0.92Co0.8Fe0.122+Fe0.083+PO4 for a sample of starting composition LiCo0.8Fe0.2PO4. Published by Elsevier B.V.
C1 [Allen, J. L.; Jow, T. R.; Wolfenstine, J.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Allen, JL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jan.l.allen8.civ@mail.mil
NR 17
TC 52
Z9 54
U1 6
U2 60
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD OCT 15
PY 2011
VL 196
IS 20
BP 8656
EP 8661
DI 10.1016/j.jpowsour.2011.06.057
PG 6
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 818GF
UT WOS:000294739000065
ER
PT J
AU Kim, HC
Han, SH
Chong, ST
Robbins, RG
Klein, TA
AF Kim, Heung Chul
Han, Sang Hoon
Chong, Sung Tae
Robbins, Richard G.
Klein, Terry A.
TI Ixodes vespertilionis Koch and first report of Ixodes simplex Neumann
(Acari: Ixodidae) from bats in the Republic of Korea
SO SYSTEMATIC AND APPLIED ACAROLOGY
LA English
DT Article
ID IXODOIDEA; ARGASIDAE; TICKS
AB Ticks were collected from bats captured in caves, abandoned mines, and under bridges in the Republic of Korea as part of the 65(th) Medical Brigade vector-borne disease surveillance program in collaboration with the National Institute of Biological Resources. A total of seven ticks (1 nymph and 3 larvae of Ixodes simplex, and 3 females of Ixodes vespertilionis) were removed from 7/141 bats (5.0%). Ixodes simplex was collected from both Rhinolophus ferrumequinum (Chiroptera: Rhinolophidae) and Miniopterus schreibersii (Chiroptera: Vespertilionidae), while I. vespertilionis was collected only from R. ferrumequinum. This is the first report of I. simplex from the Republic of Korea.
RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, AFPMB, Washington, DC 20307 USA.
EM richard.robbins@osd.mil
FU Armed Forces Health Surveillance Center (AFHSC); CAPT Clara Witt, Global
Emerging Infections Surveillance and Response System (GEIS)
FX We thank the Director, Dr. Chong-Chun Kim, and personnel of the National
Institute of Biological Resources, Incheon, Republic of Korea, for their
assistance in the collection of ectoparasites from bats. Thanks also to
Dr. Joel Gaydos, Armed Forces Health Surveillance Center (AFHSC), and
CAPT Clara Witt, Global Emerging Infections Surveillance and Response
System (GEIS), Silver Spring, MD, for their support. Funding for
portions of this research was provided by AFHSC, GEIS, and the National
Center for Medical Intelligence, Fort Detrick, MD. The opinions
expressed herein are those of the authors and are not to be construed as
official or reflecting the views of the US Department of the Army,
Department of Defense, or the US Government.
NR 25
TC 1
Z9 1
U1 1
U2 2
PU SYSTEMATIC & APPLIED ACAROLOGY SOC LONDON, NATURAL HISTORY MUSEUM
PI LONDON
PA DEPT ENTOMOLOGY, LONDON, SW7 5BD, ENGLAND
SN 1362-1971
J9 SYST APPL ACAROL-UK
JI Syst. Appl. Acarol.
PD OCT 14
PY 2011
VL 16
IS 3
BP 223
EP 227
PG 5
WC Entomology
SC Entomology
GA 841TF
UT WOS:000296535400006
ER
PT J
AU Pinto, VB
Moran, EE
Cruz, F
Wang, XM
Fridman, A
Zollinger, WD
Przysiecki, CT
Burden, R
AF Pinto, Valerian B.
Moran, Elizabeth E.
Cruz, Francisco
Wang, Xin-Ming
Fridman, Arthur
Zollinger, Wendell D.
Przysiecki, Craig T.
Burden, Robert
TI An experimental outer membrane vesicle vaccine from N. meningitidis
serogroup B strains that induces serum bactericidal activity to multiple
serogroups
SO VACCINE
LA English
DT Article
DE Neisseria meningitidis; Vaccine; Outer membrane vesicles
ID PNEUMOCOCCAL CONJUGATE VACCINE; GRAM-NEGATIVE BACTERIA;
NEISSERIA-MENINGITIDIS; MENINGOCOCCAL DISEASE; WHOLE-CELL; PROTECTIVE
IMMUNITY; ESCHERICHIA-COLI; CONTROLLED-TRIAL; PROTEIN; MICE
AB A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y. W135, X. and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains. Published by Elsevier Ltd.
C1 [Pinto, Valerian B.; Moran, Elizabeth E.; Zollinger, Wendell D.; Burden, Robert] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
[Cruz, Francisco; Fridman, Arthur] Merck Res Labs, IT Informat, Rahway, NJ 07065 USA.
[Wang, Xin-Ming; Przysiecki, Craig T.] Merck Res Labs, Vaccine Basic Res, West Point, PA 19486 USA.
RP Pinto, VB (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM valerian.pinto@us.army.mil
FU Military Infectious Disease Research Program Office of USAMRMC, U.S.
Army
FX The authors wish to express their gratitude to Dr. Robert Lee from the
FDA for kindly providing us with the anti-A capsular antibodies. Funding
for the work described in this paper was provided by the Military
Infectious Disease Research Program Office of USAMRMC, U.S. Army.
NR 49
TC 20
Z9 22
U1 3
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD OCT 13
PY 2011
VL 29
IS 44
BP 7752
EP 7758
DI 10.1016/j.vaccine.2011.07.124
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 841WW
UT WOS:000296546900030
PM 21827811
ER
PT J
AU Zhang, L
Sathunuru, R
Caridha, D
Pybus, B
O'Neil, MT
Kozar, MP
Lin, AJ
AF Zhang, Liang
Sathunuru, Ramadas
Caridha, Diana
Pybus, Brandon
O'Neil, Michael T.
Kozar, Michael P.
Lin, Al J.
TI Antimalarial Activities of New Guanidylimidazole and Guanidylimidazoline
Derivatives
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID TROPHOZOITE-INDUCED INFECTIONS; PLASMODIUM-FALCIPARUM MALARIA;
IMIDAZOLIDINEDIONE DERIVATIVES; INVITRO; TAFENOQUINE; PRIMAQUINE;
SUSCEPTIBILITY; ERYTHROCYTES; MEFLOQUINE; CYNOMOLGI
AB A series of new guanidylimidazole derivatives was prepared and evaluated in mice and Rhesus monkeys infected with malarial sporozoites. The majority of the new compounds showed poor metabolic stability and weak in vitro activities in three clones of Plasmodium falciparum. Compounds 8a, 8h, 9a, 16a, and 16e cured the mice infected with sporozoites of P. berghei at 160 and 320 mg/kg/day x 3 po. Compounds 8a showed better causal prophylactic activity than primaquine, tafenoquine, and Malarone in the Rhesus test. In the radical curative test, 8a cured one monkey and delayed relapse of another for 74 days at 30 mg/kg/day x 7 by im. By oral dosing, 8a delayed relapse 81 days for one and 32 days for other vs 11-12 days for control monkeys treated with 10 mg/kg of chloroquine by po alone. Compound 8h, which showed superior activity to 8a in mouse test, delayed the relapse of treated monkeys for 21-26 days at 30 mg/kg/day x 7 by oral.
C1 [Zhang, Liang; Sathunuru, Ramadas; Caridha, Diana; Pybus, Brandon; O'Neil, Michael T.; Kozar, Michael P.; Lin, Al J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, S03 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ai.lin@us.army.mil
FU Military Infections Diseases Research Program [A40191_09_WR]; U.S. Army
Medical Research and Material Command, Department of Defense, USA; Peer
Reviewed Medical Research Program (PRMRP) [PR054609]; Medicines for
Malaria Venture, Geneva, Switzerland [MMV 04/0013]
FX Material has been reviewed by the Walter Reed Army Institute of
Research. There is no objection to its presentation and/or publications.
The opinions or assertions contained herein are the private views of the
authors, and are not to be construed as official, or as reflecting true
views of the Department of the Army or the Department of Defense.
Research was conducted in compliance with the Animal Welfare Act and
other federal statutes and regulations relating to animals and
experiments involving animals and adheres to principles stated in the
Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996
edition. This research is supported in part by funding from Military
Infections Diseases Research Program (A40191_09_WR), U.S. Army Medical
Research and Material Command, Department of Defense, USA., Peer
Reviewed Medical Research Program (PRMRP) (grant no. PR054609), and
Medicines for Malaria Venture (MMV 04/0013), Geneva, Switzerland.
NR 35
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U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD OCT 13
PY 2011
VL 54
IS 19
BP 6634
EP 6646
DI 10.1021/jm200503s
PG 13
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 829AG
UT WOS:000295546200019
PM 21848332
ER
PT J
AU Campo, JJ
Dobano, C
Sacarlal, J
Guinovart, C
Mayor, A
Angov, E
Dutta, S
Chitnis, C
Macete, E
Aponte, JJ
Alonso, PL
AF Campo, Joseph J.
Dobano, Carlota
Sacarlal, Jahit
Guinovart, Caterina
Mayor, Alfredo
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan
Macete, Eusebio
Aponte, John J.
Alonso, Pedro L.
TI Impact of the RTS,S Malaria Vaccine Candidate on Naturally Acquired
Antibody Responses to Multiple Asexual Blood Stage Antigens
SO PLOS ONE
LA English
DT Article
ID CIRCUMSPOROZOITE PROTEIN VACCINE; PLASMODIUM-FALCIPARUM INFECTION;
ERYTHROCYTE-MEMBRANE PROTEIN-1; RANDOMIZED CONTROLLED-TRIAL;
HIGH-DENSITY PARASITEMIA; PHASE-IIB TRIAL; MOZAMBICAN CHILDREN;
MEROZOITE ANTIGENS; DOUBLE-BLIND; FOLLOW-UP
AB Background: Partial protective efficacy lasting up to 43 months after vaccination with the RTS, S malaria vaccine has been reported in one cohort (C1) of a Phase IIb trial in Mozambique, but waning efficacy was observed in a smaller contemporaneous cohort (C2). We hypothesized that low dose exposure to asexual stage parasites resulting from partial pre-erythrocytic protection afforded by RTS, S may contribute to long-term vaccine efficacy to clinical disease, which was not observed in C2 due to intense active detection of infection and treatment.
Methodology/Principal Findings: Serum collected 6 months post-vaccination was screened for antibodies to asexual blood stage antigens AMA-1, MSP-1(42), EBA-175, DBL-alpha and variant surface antigens of the R29 laboratory strain (VSA(R29)). Effect of IgG on the prospective hazard of clinical malaria was estimated. No difference was observed in antibody levels between RTS, S and control vaccine when all children aged 1-4 years at enrollment in both C1 and C2 were analyzed together, and no effects were observed between cohort and vaccine group. RTS, S-vaccinated children <2 years of age at enrollment had lower levels of IgG for AMA-1 and MSP-1(42) (p<0.01, all antigens), while no differences were observed in children >= 2 years. Lower risk of clinical malaria was associated with high IgG to EBA-175 and VSA(R29) in C2 only (Hazard Ratio [HR]: 0.76, 95% CI 0.66-0.88; HR: 0.75, 95% CI 0.62-0.92, respectively).
Conclusions: Vaccination with RTS, S modestly reduces anti-AMA-1 and anti-MSP-1 antibodies in very young children. However, for antigens associated with lower risk of clinical malaria, there were no vaccine group or cohort-specific effects, and age did not influence antibody levels between treatment groups for these antigens. The antigens tested do not explain the difference in protective efficacy in C1 and C2. Other less-characterized antigens or VSA may be important to protection.
C1 [Campo, Joseph J.; Dobano, Carlota; Guinovart, Caterina; Mayor, Alfredo; Aponte, John J.; Alonso, Pedro L.] Univ Barcelona, Hosp Clin, Ctr Recerca Salut Int Barcelona, Barcelona, Spain.
[Campo, Joseph J.; Dobano, Carlota; Sacarlal, Jahit; Guinovart, Caterina; Mayor, Alfredo; Macete, Eusebio; Aponte, John J.; Alonso, Pedro L.] Ctr Invest Saude Manhica, Manhica, Mozambique.
[Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[Chitnis, Chetan] Int Ctr Genet Engn & Biotechnol, New Delhi, India.
RP Campo, JJ (reprint author), Univ Barcelona, Hosp Clin, Ctr Recerca Salut Int Barcelona, Barcelona, Spain.
EM cdobano@clinic.ub.es
RI Dobano, Carlota/N-4119-2014
OI Dobano, Carlota/0000-0002-6751-4060
FU Program for Appropriate Technology in Health-Malaria Vaccine Initiative;
Fundacion Ramon Areces; Agencia de Gestio d'Ajuts Universitaris i de
Recerca [2010FI_B 00168]; Spanish Ministry of Science and Innovation
[RYC-2008-02631]
FX This work was supported by the Program for Appropriate Technology in
Health-Malaria Vaccine Initiative, the Fundacion Ramon Areces, the
Agencia de Gestio d'Ajuts Universitaris i de Recerca [2010FI_B 00168 to
JC] and the Spanish Ministry of Science and Innovation [RYC-2008-02631
to CD]. The Centro de Investigacao em Saude da Manhica receives core
support from the Spanish Agency for International Cooperation and
Development. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 49
TC 9
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 12
PY 2011
VL 6
IS 10
AR e25779
DI 10.1371/journal.pone.0025779
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834PW
UT WOS:000295976000038
PM 22022448
ER
PT J
AU Irish, JL
Resio, DT
Divoky, D
AF Irish, Jennifer L.
Resio, Donald T.
Divoky, David
TI Statistical properties of hurricane surge along a coast
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
ID RESPONSE FUNCTION-APPROACH; WIND
AB The validity and accuracy of approaches used to determine hurricane surge hazard risk received much attention following the hurricane seasons in mid- to late-2000, which caused record surge-related damage along the Gulf of Mexico coastline. Following Hurricane Katrina in 2005, research showed that most extreme-value statistics approaches underestimated the risk associated with this surge event. In this paper, two of the most popular methods for determining hurricane surge extreme-value statistics are reviewed: the historical surge population approach and the joint probability method. Here, it is demonstrated that both limited historical record length and random along-coast variability in hurricane landfall location can introduce significant errors into surge estimates. For example, the historical surge population approach gives errors of 9% to 17% for return periods between 50 and 1000 years when a surge record of 100 years is considered. In contrast, it is shown that the joint probability method yields significantly more reliable surge estimates, with errors of 2% to 3% for return periods between 50 and 1000 years when a storm record of 100 years is considered. Finally, we show that both methods remain robust when decadal-scale climate variability in the storm rate of occurrence is considered, so long as the hurricane history is long enough to capture the full decadal cycle. When used in conjunction with continuous surge response information, it can be concluded that the joint probability method is a practical and reliable approach for determining extreme-value hurricane surge statistics.
C1 [Irish, Jennifer L.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Divoky, David] AECOM, Atlanta, GA 30309 USA.
[Resio, Donald T.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Irish, JL (reprint author), Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Postal Code 0105, Blacksburg, VA 24061 USA.
EM jirish@vt.edu
RI Lucas, Elizabeth/E-2733-2010;
OI Irish, Jennifer/0000-0002-2429-5953
FU U.S. Army Engineer Research and Development Center, Coastal and
Hydraulics Laboratory; Office of Science (BER), U.S. Department of
Energy [DE-FG02-08ER64644]
FX This research was supported by the U.S. Army Engineer Research and
Development Center, Coastal and Hydraulics Laboratory, and the Office of
Science (BER), U.S. Department of Energy (grant DE-FG02-08ER64644). The
use of trade names does not constitute an endorsement in the use of
these products by the U.S. Government. Finally, the authors wish to
thank the journal reviewers for their insightful comments, ultimately
leading to a more comprehensive and clear presentation of this research.
NR 18
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U1 0
U2 9
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0148-0227
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD OCT 11
PY 2011
VL 116
AR C10007
DI 10.1029/2010JC006626
PG 15
WC Oceanography
SC Oceanography
GA 834TB
UT WOS:000295985900001
ER
PT J
AU Walsh, GF
Forestiere, C
Dal Negro, L
AF Walsh, Gary F.
Forestiere, Carlo
Dal Negro, Luca
TI Plasmon-enhanced depolarization of reflected light from arrays of
nanoparticle dimers
SO OPTICS EXPRESS
LA English
DT Article
ID RAMAN-SCATTERING; GRATINGS; SPHERES; WAVES
AB Using spectroscopic ellipsometry and analytical multiple scattering theory, we demonstrate significant depolarization of far-field reflected light due to plasmonic near-field concentration in dimer arrays of metallic nanoparticles fabricated by electron beam lithography. By systematically investigating dimer arrays with varying sub-wavelength interparticle separations, we show that the measured depolarization presents a sharp peak at the Rayleigh cutoff condition for efficient in-plane diffraction. Moreover, by investigating the depolarization of reflected light as a function of the excitation angle, we demonstrate that maximum depolarization occurs in the spectral regions of plasmon-enhanced near-fields. Our results demonstrate that far-field reflection measurements encode information on the near-field spectra of complex nanoparticle arrays, and can be utilized to experimentally determine the optimal conditions for the excitation of sub-wavelength plasmonic resonances. The proposed approach opens novel opportunities for the engineering of nanoparticle arrays with optimized enhancement of optical cross sections for spectroscopic and sensing applications. (C) 2011 Optical Society of America
C1 [Walsh, Gary F.; Forestiere, Carlo; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA.
[Walsh, Gary F.; Forestiere, Carlo; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA.
[Dal Negro, Luca] Boston Univ, Div Mat Sci & Engn, Boston, MA 02215 USA.
[Walsh, Gary F.] USA, NSRDEC, Nano Mat Sci Team, Natick, MA 01760 USA.
[Forestiere, Carlo] Univ Naples Federico II, Dept Elect Engn, I-80125 Naples, Italy.
RP Walsh, GF (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA.
EM dalnegro@bu.edu
RI Forestiere, Carlo/A-7986-2013; Forestiere, Carlo/L-7754-2015
OI Forestiere, Carlo/0000-0003-2849-2513
FU U.S. Army through the Natick Soldier Center [W911NF-07-D-001]; SMART
Scholarship Program; Air Force program [FA9550-10-1-0019]; NSF
[ECCS-0846651]
FX This work was partially supported by the U.S. Army through the Natick
Soldier Center (W911NF-07-D-001), the SMART Scholarship Program, the Air
Force program "Deterministic Aperiodic Structures for On-chip
Nanophotonic and Nanoplasmonic Device Applications" under Award
FA9550-10-1-0019, and from the NSF Career Award ECCS-0846651. This
document has been approved for public release. NSRDEC PAO # U11-475.
NR 36
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U1 2
U2 17
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD OCT 10
PY 2011
VL 19
IS 21
BP 21081
EP 21090
DI 10.1364/OE.19.021081
PG 10
WC Optics
SC Optics
GA 835VV
UT WOS:000296065700129
PM 21997116
ER
PT J
AU Sedegah, M
Tamminga, C
McGrath, S
House, B
Ganeshan, H
Lejano, J
Abot, E
Banania, GJ
Sayo, R
Farooq, F
Belmonte, M
Manohar, N
Richie, NO
Wood, C
Long, CA
Regis, D
Williams, FT
Shi, M
Chuang, I
Spring, M
Epstein, JE
Mendoza-Silveiras, J
Limbach, K
Patterson, NB
Bruder, JT
Doolan, DL
King, CR
Soisson, L
Diggs, C
Carucci, D
Dutta, S
Hollingdale, MR
Ockenhouse, CF
Richie, TL
AF Sedegah, Martha
Tamminga, Cindy
McGrath, Shannon
House, Brent
Ganeshan, Harini
Lejano, Jennylynn
Abot, Esteban
Banania, Glenna J.
Sayo, Renato
Farooq, Fouzia
Belmonte, Maria
Manohar, Nalini
Richie, Nancy O.
Wood, Chloe
Long, Carole A.
Regis, David
Williams, Francis T.
Shi, Meng
Chuang, Ilin
Spring, Michele
Epstein, Judith E.
Mendoza-Silveiras, Jose
Limbach, Keith
Patterson, Noelle B.
Bruder, Joseph T.
Doolan, Denise L.
King, C. Richter
Soisson, Lorraine
Diggs, Carter
Carucci, Daniel
Dutta, Sheetij
Hollingdale, Michael R.
Ockenhouse, Christian F.
Richie, Thomas L.
TI Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1.
Part A: Safety and Immunogenicity in Seronegative Adults
SO PLOS ONE
LA English
DT Article
ID APICAL MEMBRANE ANTIGEN-1; T-CELL EPITOPES; CANDIDATE MALARIA VACCINE;
PLASMODIUM-BERGHEI SPOROZOITES; NATURAL IMMUNE-RESPONSES; PRIME-BOOST
REGIMENS; BLOOD-STAGE MALARIA; PHASE I/IIA SAFETY; CIRCUMSPOROZOITE
PROTEIN; PROTECTIVE IMMUNITY
AB Background: Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting sporozoite and blood stages. We designed a multistage adenovirus 5 (Ad5)-vectored Plasmodium falciparum malaria vaccine, aiming to induce both types of responses in humans, that was tested for safety and immunogenicity in a Phase 1 dose escalation trial in Ad5-seronegative volunteers.
Methodology/Principal Findings: The NMRC-M3V-Ad-PfCA vaccine combines two adenovectors encoding circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1). Group 1 (n = 6) healthy volunteers received one intramuscular injection of 2x10(boolean AND) 10 particle units (1610(boolean AND) 10 each construct) and Group 2 (n = 6) a five-fold higher dose. Transient, mild to moderate adverse events were more pronounced with the higher dose. ELISpot responses to CSP and AMA1 peaked at 1 month, were higher in the low dose (geomean CSP = 422, AMA1 = 862 spot forming cells/million) than in the high dose (CSP = 154, p = 0.049, AMA1 = 423, p = 0.045) group and were still positive at 12 months in a number of volunteers. ELISpot depletion assays identified dependence on CD4+ or on both CD4+ and CD8+ T cells, with few responses dependent only on CD8+ T cells. Intracellular cytokine staining detected stronger CD8+ than CD4+ T cell IFN-gamma responses (CSP p = 0.0001, AMA1 p = 0.003), but similar frequencies of multifunctional CD4+ and CD8+ T cells secreting two or more of IFN-gamma, TNF-alpha or IL-2. Median fluorescence intensities were 7-10 fold higher in triple than single secreting cells. Antibody responses were low but trended higher in the high dose group and did not inhibit growth of cultured P. falciparum blood stage parasites.
Significance: As found in other trials, adenovectored vaccines appeared safe and well-tolerated at doses up to 1x10(boolean AND) 11 particle units. This is the first demonstration in humans of a malaria vaccine eliciting strong CD8+ T cell IFN-gamma responses.
C1 [Sedegah, Martha; Tamminga, Cindy; House, Brent; Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna J.; Sayo, Renato; Farooq, Fouzia; Belmonte, Maria; Manohar, Nalini; Regis, David; Chuang, Ilin; Epstein, Judith E.; Mendoza-Silveiras, Jose; Limbach, Keith; Patterson, Noelle B.; Doolan, Denise L.; Carucci, Daniel; Richie, Thomas L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[McGrath, Shannon; Richie, Nancy O.; Wood, Chloe; Spring, Michele; Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[McGrath, Shannon; Richie, Nancy O.; Wood, Chloe; Dutta, Sheetij] Clin Res Management, Hinckley, OH USA.
[Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna J.; Sayo, Renato; Farooq, Fouzia; Belmonte, Maria; Manohar, Nalini; Spring, Michele; Mendoza-Silveiras, Jose; Limbach, Keith; Patterson, Noelle B.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA.
[Williams, Francis T.] Natl Naval Med Ctr, Bethesda, MD USA.
[Shi, Meng] Walter Reed Army Inst Res, Div Med Audio Visual Lib & Stat Serv, Silver Spring, MD USA.
[Shi, Meng] Allied Technol Grp Inc, Rockville, MD USA.
[Bruder, Joseph T.; King, C. Richter] GenVec Inc, Gaithersburg, MD USA.
[Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA.
[Hollingdale, Michael R.] NMRC, Malaria Dept, USMMVP, Silver Spring, MD USA.
RP Sedegah, M (reprint author), USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
EM Martha.Sedegah@med.navy.mil
RI Belmonte, Maria/A-8032-2011; Doolan, Denise/F-1969-2015;
OI Richie, Thomas/0000-0002-2946-5456
FU Pfizer Australia; Congressionally Directed Medical Research Program
[W81XWH-05-2-0041]
FX SM NOR CW worked for Clinical Research Management and performed some of
the experiments, JTB CRK worked for GenVec and helped design the
vaccine. DLD held a Pfizer Australia Senior Research Fellowship and
helped design the vaccine. The following funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript: Congressionally Directed Medical Research
Program "Development of Recombinant Adenoviral-based Vaccines against
Malaria'' Grant #: W81XWH-05-2-0041. Website:https://cdmrp.org. Military
Infectious ResearcCongressionally Directed Medical Research Programh
Program "Phase 1/2a clinical trials assessing the safety, tolerability,
immunogenicity & protective efficacy of Ad5-CA, a two-antigen,
adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy,
malaria-naive adults'', work unit. Website:
https://midrp.amedd.army.mil.
NR 83
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U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 7
PY 2011
VL 6
IS 10
AR e24586
DI 10.1371/journal.pone.0024586
PG 22
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834OC
UT WOS:000295970300004
PM 22003383
ER
PT J
AU Tamminga, C
Sedegah, M
Regis, D
Chuang, I
Epstein, JE
Spring, M
Mendoza-Silveiras, J
McGrath, S
Maiolatesi, S
Reyes, S
Steinbeiss, V
Fedders, C
Smith, K
House, B
Ganeshan, H
Lejano, J
Abot, E
Banania, GJ
Sayo, R
Farooq, F
Belmonte, M
Murphy, J
Komisar, J
Williams, J
Shi, M
Brambilla, D
Manohar, N
Richie, NO
Wood, C
Limbach, K
Patterson, NB
Bruder, JT
Doolan, DL
King, CR
Diggs, C
Soisson, L
Carucci, D
Levine, G
Dutta, S
Hollingdale, MR
Ockenhouse, CF
Richie, TL
AF Tamminga, Cindy
Sedegah, Martha
Regis, David
Chuang, Ilin
Epstein, Judith E.
Spring, Michele
Mendoza-Silveiras, Jose
McGrath, Shannon
Maiolatesi, Santina
Reyes, Sharina
Steinbeiss, Victoria
Fedders, Charlotte
Smith, Kathryn
House, Brent
Ganeshan, Harini
Lejano, Jennylynn
Abot, Esteban
Banania, Glenna J.
Sayo, Renato
Farooq, Fouzia
Belmonte, Maria
Murphy, Jittawadee
Komisar, Jack
Williams, Jackie
Shi, Meng
Brambilla, Donald
Manohar, Nalini
Richie, Nancy O.
Wood, Chloe
Limbach, Keith
Patterson, Noelle B.
Bruder, Joseph T.
Doolan, Denise L.
King, C. Richter
Diggs, Carter
Soisson, Lorraine
Carucci, Daniel
Levine, Gail
Dutta, Sheetij
Hollingdale, Michael R.
Ockenhouse, Christian F.
Richie, Thomas L.
TI Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1.
Part B: Safety, Immunogenicity and Protective Efficacy of the CSP
Component
SO PLOS ONE
LA English
DT Article
ID APICAL MEMBRANE ANTIGEN-1; MALARIA-NAIVE ADULTS; T-CELL RESPONSES;
NATURAL IMMUNE-RESPONSES; BLOOD-STAGE VACCINE; PHASE 2A TRIAL;
PLASMODIUM-FALCIPARUM; CIRCUMSPOROZOITE PROTEIN; RECOMBINANT PROTEIN;
ADENOVIRAL VECTORS
AB Background: A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge.
Methodology/Principal Findings: NMRC-MV-Ad-PfC is an adenovirus vector encoding the Plasmodium falciparum 3D7 circumsporozoite protein (CSP). It is one component of a two-component vaccine NMRC-M3V-Ad-PfCA consisting of one adenovector encoding CSP and one encoding apical membrane antigen-1 (AMA1) that was evaluated for safety and immunogenicity in an earlier study (see companion paper, Sedegah et al). Fourteen Ad5 seropositive or negative adults received two doses of NMRC-MV-Ad-PfC sixteen weeks apart, at 1x1 (0) over cap 10 particle units per dose. The vaccine was safe and well tolerated. All volunteers developed positive ELISpot responses by 28 days after the first immunization (geometric mean 272 spot forming cells/million[sfc/m]) that declined during the following 16 weeks and increased after the second dose to levels that in most cases were less than the initial peak (geometric mean 119 sfc/m). CD8+ predominated over CD4+ responses, as in the first clinical trial. Antibody responses were poor and like ELISpot responses increased after the second immunization but did not exceed the initial peak. Pre-existing neutralizing antibodies (NAb) to Ad5 did not affect the immunogenicity of the first dose, but the fold increase in NAb induced by the first dose was significantly associated with poorer antibody responses after the second dose, while ELISpot responses remained unaffected. When challenged by the bite of P. falciparum-infected mosquitoes, two of 11 volunteers showed a delay in the time to patency compared to infectivity controls, but no volunteers were sterilely protected.
Significance: The NMRC-MV-Ad-PfC vaccine expressing CSP was safe and well tolerated given as two doses, but did not provide sterile protection.
C1 [Tamminga, Cindy; Sedegah, Martha; Regis, David; Chuang, Ilin; Epstein, Judith E.; Mendoza-Silveiras, Jose; Maiolatesi, Santina; Reyes, Sharina; Steinbeiss, Victoria; Fedders, Charlotte; Smith, Kathryn; House, Brent; Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna J.; Sayo, Renato; Farooq, Fouzia; Belmonte, Maria; Shi, Meng; Manohar, Nalini; Limbach, Keith; Patterson, Noelle B.; Doolan, Denise L.; Carucci, Daniel; Richie, Thomas L.] USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[Spring, Michele; McGrath, Shannon; Murphy, Jittawadee; Komisar, Jack; Williams, Jackie; Shi, Meng; Richie, Nancy O.; Wood, Chloe; Dutta, Sheetij; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[McGrath, Shannon; Williams, Jackie; Richie, Nancy O.; Wood, Chloe; Dutta, Sheetij] Clin Res Management, Hinckley, OH USA.
[Spring, Michele; Mendoza-Silveiras, Jose; Maiolatesi, Santina; Reyes, Sharina; Steinbeiss, Victoria; Fedders, Charlotte; Smith, Kathryn; Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna J.; Sayo, Renato; Farooq, Fouzia; Belmonte, Maria; Manohar, Nalini; Limbach, Keith; Patterson, Noelle B.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Brambilla, Donald] RTI Rockville, Rockville, MD USA.
[Bruder, Joseph T.; King, C. Richter] GenVec Inc, Gaithersburg, MD USA.
[Diggs, Carter; Soisson, Lorraine] USAID, Washington, DC USA.
[Levine, Gail] Fdn Natl Inst Hlth, Bethesda, MD USA.
[Hollingdale, Michael R.] NMRC, USMMVP, Malaria Dept, Silver Spring, MD USA.
RP Tamminga, C (reprint author), USN, Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
EM cindy.tamminga@med.navy.mil
RI Belmonte, Maria/A-8032-2011; Doolan, Denise/F-1969-2015;
OI Richie, Thomas/0000-0002-2946-5456
FU USAID [GHA-P00-03-00006-01, 936-3118]; Congressionally Directed Medical
Research Program [W81XWH-05-2-0041]
FX The following funder played a role in study design: CD and LS from
USAID: "Development of Adenovirus-Vectored Malaria Vaccines" Grant #:
GHA-P00-03-00006-01, PROJECT NUMBER 936-3118. Web site:
http://www.usaid.gov. SM, NOR, CW, and SD are employees of Clinical
Research Management and performed some of the experiments and SM also
participated in writing the manuscript. JTB and CRK employees of GenVec,
Inc., and participated in the design of the vaccines. The following
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript: Congressionally
Directed Medical Research Program "Development of Recombinant
Adenoviral-based Vaccines against Malaria" Grant #: W81XWH-05-2-0041.
Website: https://cdmrp.org. Military Infectious Research Program "Phase
1/2a clinical trials assessing the safety, tolerability, immunogenicity
& protective efficacy of Ad5-CA, a two-antigen, adenovirus-vectored
Plasmodium falciparum malaria vaccine, in healthy, malaria-naive
adults", work unit. Website: https://midrp.amedd.army.mil.
NR 84
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U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 7
PY 2011
VL 6
IS 10
AR e25868
DI 10.1371/journal.pone.0025868
PG 20
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834OC
UT WOS:000295970300034
PM 22003411
ER
PT J
AU Wu, J
Park, JP
Dooley, K
Cropek, DM
West, AC
Banta, S
AF Wu, Jun
Park, Jong Pil
Dooley, Kevin
Cropek, Donald M.
West, Alan C.
Banta, Scott
TI Rapid Development of New Protein Biosensors Utilizing Peptides Obtained
via Phage Display
SO PLOS ONE
LA English
DT Article
ID QUARTZ-CRYSTAL MICROBALANCE; MODIFIED GOLD ELECTRODES; ALANINE
AMINOTRANSFERASE; ASPARTATE-AMINOTRANSFERASE; IMPEDANCE SPECTROSCOPY;
CYTOCHROME-C; RECOGNITION; SERUM; IMMUNOSENSOR; TRANSAMINASE
AB There is a consistent demand for new biosensors for the detection of protein targets, and a systematic method for the rapid development of new sensors is needed. Here we present a platform where short unstructured peptides that bind to a desired target are selected using M13 phage display. The selected peptides are then chemically synthesized and immobilized on gold, allowing for detection of the target using electrochemical techniques such as electrochemical impedance spectroscopy (EIS). A quartz crystal microbalance (QCM) is also used as a diagnostic tool during biosensor development. We demonstrate the utility of this approach by creating a novel peptide-based electrochemical biosensor for the enzyme alanine aminotransferase (ALT), a well-known biomarker of hepatotoxicity. Biopanning of the M13 phage display library over immobilized ALT, led to the rapid identification of a new peptide (ALT5-8) with an amino acid sequence of WHWRNPDFWYLK. Phage particles expressing this peptide exhibited nanomolar affinity for immobilized ALT (K(d,app)= 85 +/- 20 nM). The newly identified ALT5-8 peptide was then chemically synthesized with a C-terminal cysteine for gold immobilization. The performance of the gold-immobilized peptides was studied with cyclic voltammetry (CV), QCM, and EIS. Using QCM, the sensitivity for ALT detection was 8.9 +/- 0.9 Hz/(mu g/mL) and the limit of detection (LOD) was 60 ng/mL. Using EIS measurements, the sensitivity was 142 +/- 12 impedance percentage change %/(mu g/mL) and the LOD was 92 ng/mL. In both cases, the LOD was below the typical concentration of ALT in human blood. Although both QCM and EIS produced similar LODs, EIS is preferable due to a larger linear dynamic range. Using QCM, the immobilized peptide exhibited a nanomolar dissociation constant for ALT (K(d) = 20.1 +/- 0.6 nM). These results demonstrate a simple and rapid platform for developing and assessing the performance of sensitive, peptide-based biosensors for new protein targets.
C1 [Wu, Jun; Park, Jong Pil; Dooley, Kevin; West, Alan C.; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY USA.
[Cropek, Donald M.] USA, Engineer Res & Dev Ctr, CERL, Champaign, IL USA.
RP Wu, J (reprint author), Atotech USA Inc, Albany, NY USA.
EM sbanta@columbia.edu
FU United States Army Corps of Engineers Applied Research program
FX This study was funded by the United States Army Corps of Engineers
Applied Research program. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 46
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U1 5
U2 51
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 7
PY 2011
VL 6
IS 10
AR e24948
DI 10.1371/journal.pone.0024948
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834OC
UT WOS:000295970300006
PM 22003385
ER
PT J
AU Allen, CJ
Mukerjee, S
Plichta, EJ
Hendrickson, MA
Abraham, KM
AF Allen, Chris J.
Mukerjee, Sanjeey
Plichta, Edward J.
Hendrickson, Mary A.
Abraham, K. M.
TI Oxygen Electrode Rechargeability in an Ionic Liquid for the Li-Air
Battery
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID TEMPERATURE MOLTEN-SALT; REDUCTION; DISCHARGE; DIOXYGEN;
ELECTROREDUCTION; SUPEROXIDE; BEHAVIOR
AB Oxygen reduction reactions (ORRs) and oxygen evolution reactions (OERs) on glassy carbon (GC) and gold electrodes were investigated in a neat and Li(+)-containing room-temperature ionic liquid (RTIL), 1-ethyl-3-methylimidazolium bis(triflouromethanesulfonyl)imide (EMITFSI). The presence of Li(+) significantly changes the ORR mechanism. While similar one-electron O(2)/O(2)(center dot-) reversible couples result on both electrodes in neat EMITFSI, in the presence of added LiTFSI, the initially formed LiO(2) decomposes to Li(2)O(2). In addition, the ORR and OER in the Li(+)-doped solution exhibit strong distinctions between the Au and GC electrodes. The voltammetric data on the Au electrode revealed a highly rechargeable ORR, yielding LiO(2) and Li(2)O(2), which underwent multiple cycles without electrode passivation.
SECTION: Energy Conversion and Storage
C1 [Allen, Chris J.; Mukerjee, Sanjeey; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, NE Univ Ctr Renewable Energy Technol NUCRET, Boston, MA 02115 USA.
[Plichta, Edward J.; Hendrickson, Mary A.] USA, CERDEC, Army Power Div, Ft Monmouth, NJ 07703 USA.
RP Abraham, KM (reprint author), Northeastern Univ, Dept Chem & Chem Biol, NE Univ Ctr Renewable Energy Technol NUCRET, 360 Huntington Ave,317 Egan Res Ctr, Boston, MA 02115 USA.
EM kmabraham@comcast.net
FU U.S. Army Cerdec [GTS-S-10-392]
FX Financial support for this work was provided by the U.S. Army Cerdec
through Subcontract No. GTS-S-10-392.
NR 20
TC 92
Z9 92
U1 8
U2 119
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD OCT 6
PY 2011
VL 2
IS 19
BP 2420
EP 2424
DI 10.1021/jz201070t
PG 5
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 846JM
UT WOS:000296893500008
ER
PT J
AU Mukhopadhyay, S
Scheicher, RH
Pandey, R
Karna, SP
AF Mukhopadhyay, Saikat
Scheicher, Ralph H.
Pandey, Ravindra
Karna, Shashi P.
TI Sensitivity of Boron Nitride Nanotubes toward Biomolecules of Different
Polarities
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID SINGLE-WALLED CARBON; AMINO-ACIDS; FUNCTIONALIZATION; PROTEINS;
ADSORPTION; IMMOBILIZATION; 1ST-PRINCIPLES; ENCAPSULATION; RECOGNITION;
COVALENT
AB The effect of molecular polarity on the interaction between a boron nitride nanotube (BNNT) and amino acids is investigated with density functional theory. Three representative amino acids, namely, tryptophane (Trp), a nonpolar aromatic amino acid, and asparatic acid (Asp) and argenine (Arg), both polar amino acids are considered for their interactions with BNNT. The polar molecules, Asp and Arg, exhibit relatively stronger binding with the tubular surface of BNNT. The binding between the polar amino acid molecules and BNNT is accompanied by a charge transfer, suggesting that stabilization of the bioconjugated complex is mainly governed by electrostatic interactions. The results show modulation of the BNNT band gap by Trp. Interestingly, no change in band gap of BNNT is seen for the polar molecules Asp and Arg. The predicted higher sensitivity of BNNTs compared to carbon nanotubes (CNTs) toward amino acid polarity suggests BNNTs to be a better substrate for protein immobilization than CNTs.
SECTION: Nanoparticles and Nanostructures
C1 [Mukhopadhyay, Saikat; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Scheicher, Ralph H.] Uppsala Univ, Dept Phys & Astron, SE-75120 Uppsala, Sweden.
[Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, 1400 Townsend Dr, Houghton, MI 49931 USA.
EM pandey@mtu.edu; Shashi.p.karna.civ@mail.mil
RI Scheicher, Ralph/G-1740-2012; Mukhopadhyay, Saikat/B-4402-2011
FU Army Research Office [W911NF-09-1-0221]; Swedish Research Council (VR)
[621-2009-3628]
FX Helpful discussions with Sankara Gowtham are thankfully acknowledged.
The work at Michigan Technological University was performed under
support by the Army Research Office through Contract Number
W911NF-09-1-0221. R.H.S. thanks the Swedish Research Council (VR, Grant
No. 621-2009-3628) for financial support.
NR 44
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U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD OCT 6
PY 2011
VL 2
IS 19
BP 2442
EP 2447
DI 10.1021/jz2010557
PG 6
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 846JM
UT WOS:000296893500012
ER
PT J
AU Wahl-Jensen, V
Cann, JA
Rubins, KH
Huggins, JW
Fisher, RW
Johnson, AJ
de Kok-Mercado, F
Larsen, T
Raymond, JL
Hensley, LE
Jahrling, PB
AF Wahl-Jensen, Victoria
Cann, Jennifer A.
Rubins, Kathleen H.
Huggins, John W.
Fisher, Robert W.
Johnson, Anthony J.
de Kok-Mercado, Fabian
Larsen, Thomas
Raymond, Jo Lynne
Hensley, Lisa E.
Jahrling, Peter B.
TI Progression of Pathogenic Events in Cynomolgus Macaques Infected with
Variola Virus
SO PLOS ONE
LA English
DT Article
ID GLOBAL ERADICATION; SMALLPOX; PREGNANCY; HISTOLOGY; MOUSEPOX
AB Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s. Subsequent cessation of vaccination has resulted in an immunologically naive human population that would be at risk should VARV be used as an agent of bioterrorism. The development of antivirals and improved vaccines to counter this threat would be facilitated by the development of animal models using authentic VARV. Towards this end, cynomolgus macaques were identified as adequate hosts for VARV, developing ordinary or hemorrhagic smallpox in a dose-dependent fashion. To further refine this model, we performed a serial sampling study on macaques exposed to doses of VARV strain Harper calibrated to induce ordinary or hemorrhagic disease. Several key differences were noted between these models. In the ordinary smallpox model, lymphoid and myeloid hyperplasias were consistently found whereas lymphocytolysis and hematopoietic necrosis developed in hemorrhagic smallpox. Viral antigen accumulation, as assessed immunohistochemically, was mild and transient in the ordinary smallpox model. In contrast, in the hemorrhagic model antigen distribution was widespread and included tissues and cells not involved in the ordinary model. Hemorrhagic smallpox developed only in the presence of secondary bacterial infections - an observation also commonly noted in historical reports of human smallpox. Together, our results support the macaque model as an excellent surrogate for human smallpox in terms of disease onset, acute disease course, and gross and histopathological lesions.
C1 [Wahl-Jensen, Victoria; Cann, Jennifer A.; Johnson, Anthony J.; de Kok-Mercado, Fabian; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21701 USA.
[Rubins, Kathleen H.] MIT, Whitehead Inst Biomed Res, Cambridge, MA USA.
[Huggins, John W.; Fisher, Robert W.; Larsen, Thomas; Raymond, Jo Lynne; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Wahl-Jensen, V (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21701 USA.
EM jahrlingp@niaid.nih.gov
FU U.S. Department of Homeland Security for the management for the
management and operation of the National Biodefense Analysis and
Countermeasures Center (NBACC) [HSHQDC-07-C-00020]; National Institute
of Allergy and Infectious Diseases [HHSN27220020000161]
FX This study was funded in part under agreement no. HSHQDC-07-C-00020
awarded by the U.S. Department of Homeland Security for the management
and operation of the National Biodefense Analysis and Countermeasures
Center (NBACC), a Federally Funded Research and Development Center. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The principal
authors (WWJ and JAC) are employees of Battelle Memorial Institute under
its prime contract with National Institute of Allergy and Infectious
Diseases # HHSN27220020000161.
NR 28
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U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 6
PY 2011
VL 6
IS 10
AR e24832
DI 10.1371/journal.pone.0024832
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834NO
UT WOS:000295968700005
PM 21998632
ER
PT J
AU Porter, DW
Thompson, FM
Berthoud, TK
Hutchings, CL
Andrews, L
Biswas, S
Poulton, I
Prieur, E
Correa, S
Rowland, R
Lang, T
Williams, J
Gilbert, SC
Sinden, RE
Todryk, S
Hill, AVS
AF Porter, David W.
Thompson, Fiona M.
Berthoud, Tamara K.
Hutchings, Claire L.
Andrews, Laura
Biswas, Sumi
Poulton, Ian
Prieur, Eric
Correa, Simon
Rowland, Rosalind
Lang, Trudie
Williams, Jackie
Gilbert, Sarah C.
Sinden, Robert E.
Todryk, Stephen
Hill, Adrian V. S.
TI A human Phase I/IIa malaria challenge trial of a polyprotein malaria
vaccine
SO VACCINE
LA English
DT Article
DE Malaria; Vaccine; Heterologous prime-boost
ID PLASMODIUM-FALCIPARUM MALARIA; POLYMERASE-CHAIN-REACTION; VIRUS ANKARA;
VIRAL VECTORS; GAMBIAN MEN; ANTIGEN; IMMUNOGENICITY; SPOROZOITES;
EFFICACY; PARASITE
AB We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum.
Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-gamma ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Porter, David W.; Thompson, Fiona M.; Poulton, Ian; Rowland, Rosalind; Lang, Trudie; Hill, Adrian V. S.] Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England.
[Berthoud, Tamara K.; Hutchings, Claire L.; Andrews, Laura; Biswas, Sumi; Prieur, Eric; Gilbert, Sarah C.; Todryk, Stephen; Hill, Adrian V. S.] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England.
[Correa, Simon] Med Res Council MRC Labs, Fajara, Gambia.
[Williams, Jackie] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Sinden, Robert E.] Univ London Imperial Coll Sci Technol & Med, Infect & Immun Sect, Dept Biol, London SW7 2AZ, England.
RP Porter, DW (reprint author), Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Old Rd, Oxford OX3 7LJ, England.
EM david.porter@paediatrics.ox.ac.uk
OI Gilbert, Sarah/0000-0002-6823-9750
FU European Vaccine Initiative (EVI)
FX This study was principally funded by the European Malaria Vaccine
Initiative (EMVI) now European Vaccine Initiative (EVI). The authors
would like to thank Odile Leroy and Egeruan Imoukhuede for advice and
support. Additional support from the Wellcome Trust and the NIHR Oxford
Biomedical Research Centre is gratefully acknowledged. SG is a Jenner
Institute Investigator and AVSH is a Wellcome Trust Principal Research
Fellow.
NR 30
TC 28
Z9 28
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD OCT 6
PY 2011
VL 29
IS 43
BP 7514
EP 7522
DI 10.1016/j.vaccine.2011.03.083
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 838SC
UT WOS:000296311500028
PM 21501642
ER
PT J
AU Luo, YT
Guo, JC
Wang, CS
Chu, D
AF Luo, Yanting
Guo, Juchen
Wang, Chunsheng
Chu, Deryn
TI Tunable High-Molecular-Weight Anion-Exchange Membranes for Alkaline Fuel
Cells
SO MACROMOLECULAR CHEMISTRY AND PHYSICS
LA English
DT Article
DE alkaline anion-exchange membranes; emulsion polymerization; fuel cells;
membranes; polymer electrolytes
ID MINIEMULSION POLYMERIZATION; ELECTROLYTE; IONOMERS; POLYMERS
AB Tunable alkaline anion-exchange membranes based on QPMBV are synthesized using a bottom-up approach, miniemulsion copolymerization, which can incorporate functional groups into the copolymers with designated composition and high molecular weight. The mechanical and electrochemical properties of the obtained QPMBV membranes are tuned by varying the composition. It is found that the ion exchange capacity of the copolymer, the hydrophilicity of the copolymer chains, the molecular weight, and the glass transition temperature of the copolymers are essential to balance the mechanical and OH(-) transport properties of QPMBV membranes. QPMBV membrane fuel cells show the best power output and the long-lasting fuel cell performance among the APE membranes in open literature.
C1 [Luo, Yanting; Guo, Juchen; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Chu, Deryn] USA, Res Lab, Sensors & Electron Device Directorate, Adelphi, MD 20783 USA.
RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
EM cswang@umd.edu
RI Cheng, Shanshan/H-3770-2011; Wang, Chunsheng/H-5767-2011
OI Wang, Chunsheng/0000-0002-8626-6381
FU Office of Naval Research [N000140810717]; Army Research Lab
[W911NF0920007]; Army Research Office [W911NF0910028]
FX This research was supported by the Office of Naval Research
(N000140810717), the Army Research Lab (W911NF0920007), and the Army
Research Office (W911NF0910028). The authors are grateful to Prof. P.
Kofinas at the University of Maryland for the technical support.
NR 33
TC 15
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U1 1
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1022-1352
J9 MACROMOL CHEM PHYS
JI Macromol. Chem. Phys.
PD OCT 4
PY 2011
VL 212
IS 19
BP 2094
EP 2102
DI 10.1002/macp.201100218
PG 9
WC Polymer Science
SC Polymer Science
GA 825EJ
UT WOS:000295253400003
ER
PT J
AU Belenky, G
Donetsky, D
Kipshidze, G
Wang, D
Shterengas, L
Sarney, WL
Svensson, SP
AF Belenky, G.
Donetsky, D.
Kipshidze, G.
Wang, D.
Shterengas, L.
Sarney, W. L.
Svensson, S. P.
TI Properties of unrelaxed InAs1-XSbX alloys grown on compositionally
graded buffers
SO APPLIED PHYSICS LETTERS
LA English
DT Article
DE buffer layers; carrier lifetime; III-V semiconductors; indium compounds;
lattice constants; molecular beam epitaxial growth; photoluminescence;
semiconductor epitaxial layers; semiconductor growth
ID MOLECULAR-BEAM EPITAXY; SUPERLATTICES; LAYERS; INSB; PHOTOLUMINESCENCE;
GAAS
AB Unrelaxed InAs1-xSbx layers with lattice constants up to 2.1% larger than that of GaSb substrates were grown by molecular beam epitaxy on GaInSb and AlGaInSb compositionally graded buffer layers. The topmost section of the buffers was unrelaxed but strained. The in-plane lattice constant of the top buffer layer was grown to be equal to the lattice constant of unrelaxed and unstrained InAs1-xSbx with given X. The InAs0.56Sb0.44 layers demonstrate photoluminescence peak at 9.4 mu m at 150 K. The minority carrier lifetime measured at 77K for InAs0.8Sb0.2 was tau = 250 ns. (C) 2011 American Institute of Physics. [doi:10.1063/1.3650473]
C1 [Belenky, G.; Donetsky, D.; Kipshidze, G.; Wang, D.; Shterengas, L.] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
[Sarney, W. L.; Svensson, S. P.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Belenky, G (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
EM garik@ece.sunysb.edu
FU NSF [DMR0710154]; ARO [W911NF11-1-0109]
FX The work was supported by NSF (Grant No. DMR0710154) and ARO (Grant No.
W911NF11-1-0109).
NR 14
TC 24
Z9 25
U1 0
U2 18
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD OCT 3
PY 2011
VL 99
IS 14
AR 141116
DI 10.1063/1.3650473
PG 3
WC Physics, Applied
SC Physics
GA 829ZE
UT WOS:000295625100016
ER
PT J
AU Hinchey, S
LaRochelle, J
Maurer, D
Shimeall, WT
Durning, SJ
DeZee, KJ
AF Hinchey, Sherri
LaRochelle, Jeff
Maurer, Douglas
Shimeall, William T.
Durning, Steven J.
DeZee, Kent J.
TI Association Between Interest Group Participation and Choice of Residency
SO FAMILY MEDICINE
LA English
DT Article
ID MEDICINE INTEREST-GROUPS; INTERNAL-MEDICINE; SPECIALTY CHOICE; STUDENT
INTEREST; PERCEPTIONS; SCHOOL; IMPACT
AB BACKGROUND AND OBJECTIVES: While medical student interest groups (IGs, also known as student clubs) are widely offered, their actual use and effectiveness to affect students' specialty choice (eg, increase selection of family medicine) are poorly understood. We performed this study to describe student participation in IGs, association with specialty selection, and perceived benefit of participation.
METHODS: An electronic, cross-sectional, quantitative survey of all fourth-year US medical students in 2009 with a Department of Defense service obligation was conducted. Each participant indicated which of 18 listed IGs they attended with a yes or no response. Each participant also rated the overall benefit of IGs on a 9-point scale and provided their top choice for the residency Match.
RESULTS: The response rate was 53% (419/797). Students attended an average of 3.5 specialty IGs. For all 18 specialties queried, IG attendance was associated with selection in the Match, and 77% of students attended the IG of their selected specialty. However, IG participation was perceived as having a small effect on specialty choice, as the mean response was 3.6 (standard deviation=2.4) on a 1 to 9 scale.
CONCLUSIONS: IG participation is common and is strongly associated with specialty choice, but the benefit appears to be small. (Fam Med 2011;43(9):648-52.)
C1 [Hinchey, Sherri] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[LaRochelle, Jeff; Durning, Steven J.; DeZee, Kent J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Maurer, Douglas] Carl R Darnall Army Med Ctr, Family Med Residency Program, Ft Hood, TX USA.
[Shimeall, William T.] Natl Naval Med Ctr, Internal Med Residency Program, Bethesda, MD USA.
RP Hinchey, S (reprint author), Tripler Army Med Ctr, Tripler, HI 96818 USA.
EM Sherifat.A.Hinchey@us.army.mil
NR 15
TC 4
Z9 4
U1 0
U2 5
PU SOC TEACHERS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA
SN 0742-3225
J9 FAM MED
JI Fam. Med.
PD OCT
PY 2011
VL 43
IS 9
BP 648
EP 652
PG 5
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 971IR
UT WOS:000306198100007
PM 22002777
ER
PT J
AU Annaswamy, TM
De Luigi, AJ
O'Neill, BJ
Keole, N
Berbrayer, D
AF Annaswamy, Thiru Mandyam
De Luigi, Arthur J.
O'Neill, Bryan J.
Keole, Nandita
Berbrayer, David
TI Emerging Concepts in the Treatment of Myofascial Pain: A Review of
Medications, Modalities, and Needle-based Interventions
SO PM&R
LA English
DT Review
ID BOTULINUM-TOXIN-A; PLACEBO-CONTROLLED TRIAL; TRIGGER-POINT INJECTION;
LEVEL LASER THERAPY; LOW-POWER LASER; LOW-BACK-PAIN; RANDOMIZED
CONTROLLED-TRIAL; DOUBLE-BLIND CROSSOVER; UPPER TRAPEZIUS MUSCLE;
CHRONIC NECK PAIN
AB Significant developments and changes in the use of interventions and treatments for the management of myofascial pain syndrome have occurred in the past 10 years. These emerging concepts have changed the approach for clinicians who manage these pain disorders. However, wide variations in practice patterns prevail, and no clear consensus exists regarding when and how to use these interventions; in addition, awareness of the evidence basis behind their use is limited. This review examines the most recent advances in the treatment of myofascial pain syndromes. Specifically, the evidence basis of various emerging interventions is reviewed and recommendations for routine clinical practice and their rationale are provided. The purpose of this review is to provide the clinician with a better understanding of emerging concepts in the interventions used for myofascial pain syndromes. PM R 2011;3:940-961
C1 [Annaswamy, Thiru Mandyam] Dallas VA Med Ctr, Electrodiagnost Sect, PM&R Serv, Dallas, TX 75216 USA.
[Annaswamy, Thiru Mandyam] Dallas VA Med Ctr, Spine Sect, PM&R Serv, Dallas, TX 75216 USA.
[Annaswamy, Thiru Mandyam] Univ Texas SW Med Ctr Dallas, Dept Phys Med & Rehabil, Dallas, TX 75390 USA.
[De Luigi, Arthur J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, PM&R Serv, Washington, DC 20307 USA.
[De Luigi, Arthur J.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
[O'Neill, Bryan J.] Neurol Grp Bucks Montgomery Counties, N Wales, PA USA.
[O'Neill, Bryan J.] Thomas Jefferson Univ, Dept Rehabil Med, Philadelphia, PA 19107 USA.
[Keole, Nandita] Integris Canc Inst Oklahoma, Oklahoma City, OK USA.
[Berbrayer, David] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada.
RP Annaswamy, TM (reprint author), Dallas VA Med Ctr, Electrodiagnost Sect, PM&R Serv, 4500 S Lancaster Rd, Dallas, TX 75216 USA.
EM thiru.annaswamy@va.gov
NR 144
TC 11
Z9 11
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD OCT
PY 2011
VL 3
IS 10
BP 940
EP 961
DI 10.1016/j.pmrj.2011.06.013
PG 22
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 966YC
UT WOS:000305872300007
PM 22024326
ER
PT J
AU Rigg, JL
Mooney, SR
AF Rigg, John L.
Mooney, Scott R.
TI Concussions and the Military: Issues Specific to Service Members
SO PM&R
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; PERSISTENT
POSTCONCUSSIVE SYMPTOMS; RANDOMIZED CONTROLLED-TRIAL; BODY SKILLS
GROUPS; BASE RATES; HEAD-INJURY; HYPOTHERMIA; DEPRESSION; IRAQ
AB Since October 2001, more than 1.6 million American military service members have deployed to Iraq and Afghanistan in the Global War on Terrorism. It is estimated that between 5% and 35% of them have sustained a concussion, also called mild traumatic brain injury (mTBI), during their deployment. Up to 80% of the concussions experienced in theater are secondary to blast exposures. The unique circumstances and consequences of sustaining a concussion in combat demands a unique understanding and treatment plan. The current literature was reviewed and revealed a paucity of pathophysiological explanations on the nature of the injury and informed treatment plans. However, through observation and experience, a theoretical but scientifically plausible model for why and how blast injuries experienced in combat give rise to the symptoms that affect day-to-day function of service members who have been concussed has been developed. We also are able to offer treatment strategies based on our evaluation of the current literature and experience to help palliate postconcussive symptoms. The purpose of this review is to elucidate common physical, cognitive, emotional, and situational challenges, and possible solutions for this special population of patients who will be transitioning into the civilian sector and interfacing with health professionals. There is a need for further investigation and testing of these strategies. PM R 2011;3:S380-S386
C1 [Rigg, John L.; Mooney, Scott R.] Dwight D Eisenhower Army Med Ctr, Traumat Brain Injury Program, Neurosci & Rehabil Ctr, Ft Gordon, GA USA.
RP Rigg, JL (reprint author), Dwight D Eisenhower Army Med Ctr, Traumat Brain Injury Program, Neurosci & Rehabil Ctr, Ft Gordon, GA USA.
EM john.l.rigg@us.army.mil
NR 50
TC 22
Z9 23
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD OCT
PY 2011
VL 3
IS 10
SU 3
BP S380
EP S386
DI 10.1016/j.pmrj.2011.08.005
PG 7
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 966YK
UT WOS:000305873100005
PM 22035680
ER
PT J
AU Dempsey, JK
Cooper, CB
AF Dempsey, Jason K.
Cooper, C. Bradford
TI Joining Forces: Bridging the Civil-Military Divide
SO FORUM-A JOURNAL OF APPLIED RESEARCH IN CONTEMPORARY POLITICS
LA English
DT Article
DE civil-military relations; military families; post-9/11 generation;
veterans; spouses
AB This paper focuses on the members of the military and their families who have served on behalf of the American public over the last ten years of conflict. Typically referred to as the "9/11 Generation," this extraordinary cohort of young Americans has already made major sacrifices for the American people, yet has the potential for continued service as members of the academic, and broader American, community. Yet military families also face distinctive challenges that are not always considered under the rubric of civil-military relations. The paper focuses on these by outlining the military families initiative known as Joining Forces, and suggests steps that the academic community can undertake to strengthen the connection between the military and the public it serves.
C1 [Dempsey, Jason K.] USA, Washington, DC 20310 USA.
[Cooper, C. Bradford] USN, Stennis Space Ctr, MS USA.
[Dempsey, Jason K.] US Mil Acad, West Point, NY 10996 USA.
RP Dempsey, JK (reprint author), USA, Washington, DC 20310 USA.
NR 3
TC 0
Z9 0
U1 0
U2 5
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1540-8884
J9 FORUM-J APPL RES CON
JI Forum-A J. Appl. Res. Contemp. Polit.
PD OCT
PY 2011
VL 9
IS 3
AR 9
DI 10.2202/1540-8884.1461
PG 8
WC Political Science
SC Government & Law
GA 952AM
UT WOS:000304762100010
ER
PT J
AU Griswold, JC
AF Griswold, John C.
TI The Changing of the Guard: The National Guard's Role in American
Politics
SO FORUM-A JOURNAL OF APPLIED RESEARCH IN CONTEMPORARY POLITICS
LA English
DT Article
DE National Guard; civil-military relations; War on Drugs; War on Terror;
Hurricane Katrina
AB This paper examines an aspect of United States armed forces that has been under-studied in the discipline of political science over the past three decades: the National Guard. The Guard's roles, responsibilities, and relationships with the states and the federal government have changed significantly since the end of the Vietnam War, from "weekend warriors" to an integral component of the national security enterprise. The paper begins by defining the Guard and its constitutional role in American national security, and then evaluates the state of the political science literature on the National Guard. It illustrates changes to the Guard using three recent cases: the War on Drugs, the War on Terror, and Hurricane Katrina. Finally, it explores potential implications of these cases and other recent events on the future role of the National Guard in American politics.
C1 [Griswold, John C.] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
[Griswold, John C.] Univ Washington, Dept Polit Sci, Seattle, WA 98195 USA.
RP Griswold, JC (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
NR 37
TC 0
Z9 0
U1 0
U2 3
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1540-8884
J9 FORUM-J APPL RES CON
JI Forum-A J. Appl. Res. Contemp. Polit.
PD OCT
PY 2011
VL 9
IS 3
AR 3
DI 10.2202/1540-8884.1463
PG 23
WC Political Science
SC Government & Law
GA 952AM
UT WOS:000304762100004
ER
PT J
AU Asike, M
Betteridge, J
Veerappan, G
Maydonovitch, C
Wong, R
AF Asike, Michael
Betteridge, John
Veerappan, Ganesh
Maydonovitch, Corinne
Wong, Roy
TI Patients Undergoing Bariatric Evaluation Do Not Have Increased
Gastroesophageal Reflux
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Asike, Michael; Betteridge, John; Veerappan, Ganesh; Maydonovitch, Corinne; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 24
BP S10
EP S10
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772000025
ER
PT J
AU Goldberg, M
Horwhat, J
AF Goldberg, Michael
Horwhat, John
TI Phentermine Induced Ischemic Colitis
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Goldberg, Michael; Horwhat, John] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 858
BP S320
EP S320
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772001423
ER
PT J
AU Moawad, F
Dias, J
Veerappan, G
Baker, T
Maydonovitch, C
Wong, R
AF Moawad, Fouad
Dias, Johnny
Veerappan, Ganesh
Baker, Thomas
Maydonovitch, Corinne
Wong, Roy
TI Comparison of Aerosolized Swallowed Fluticasone to Esomeprazole for the
Treatment of Eosinophilic Esophagitis
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Moawad, Fouad; Dias, Johnny; Veerappan, Ganesh; Baker, Thomas; Maydonovitch, Corinne; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 4
Z9 4
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 30
BP S12
EP S12
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772000031
ER
PT J
AU Parasher, V
Horwhat, J
Settle, T
AF Parasher, Vinod
Horwhat, John
Settle, Timothy
TI EUS Guided Transesophageal Thoracic Duct Puncture in a Swine Model, A
Survival Study
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Parasher, Vinod] Johns Hopkins Univ, Sinai Hosp, Baltimore, MD USA.
[Horwhat, John; Settle, Timothy] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 1358
BP S520
EP S520
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772002201
ER
PT J
AU Spearman, D
Laczek, J
Maydonovitch, C
Veerappan, G
AF Spearman, Darren
Laczek, Jeffrey
Maydonovitch, Corinne
Veerappan, Ganesh
TI The Compassionate Use of Domperidone in Patients with Gastroparesis
Refractory to Standard Therapy: The Walter Reed Experience
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Spearman, Darren; Laczek, Jeffrey; Maydonovitch, Corinne; Veerappan, Ganesh] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 88
BP S37
EP S37
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772000089
ER
PT J
AU Wills, TR
Goldwire, F
Norris, W
AF Wills, Ta Ressa
Goldwire, Franklin
Norris, William
TI An Unusual Case of Pancreatic Cancer
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 76th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 28-NOV 02, 2011
CL Washington, DC
SP Amer Coll Gastroenterol
C1 [Wills, Ta Ressa; Goldwire, Franklin; Norris, William] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2011
VL 106
SU 2
MA 560
BP S215
EP S215
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 885II
UT WOS:000299772001130
ER
PT J
AU Cecchi, V
St Leger, A
Miu, KR
Nwankpa, CO
AF Cecchi, Valentina
St Leger, Aaron
Miu, Karen
Nwankpa, Chika O.
TI Incorporating Temperature Variations Into Transmission-Line Models
SO IEEE TRANSACTIONS ON POWER DELIVERY
LA English
DT Article
DE Ambient temperature; distributed parameter circuits; nonuniform
transmission lines; power system modeling; power transmission lines
ID LOAD
AB This paper discusses a transmission-line modeling approach that incorporates available ambient temperature information. Several proposed line modeling techniques are studied and include distributed and lumped parameter models. In order to capture the nonuniformity of line parameters caused by temperature gradients, a model with multiple nonuniform segments is also proposed. An automated tool has been developed to obtain appropriate line model segmentation and parameter values of each segment, given a set of temperature measurements and their locations along the line.
C1 [Cecchi, Valentina] Univ N Carolina, Dept Elect & Comp Engn, Charlotte, NC 28203 USA.
[St Leger, Aaron] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10566 USA.
[Miu, Karen; Nwankpa, Chika O.] Drexel Univ, Ctr Elect Power Engn, Philadelphia, PA 19104 USA.
RP Cecchi, V (reprint author), Univ N Carolina, Dept Elect & Comp Engn, Charlotte, NC 28203 USA.
EM vcecchi@uncc.edu; aaron.stleger@usma.edu; Karen@coe.drexel.edu;
chika@mail.ece.drexel.edu
FU ONR [N0014-04-1-0404]
FX This work was supported by ONR N0014-04-1-0404. Paper no.
TPWRD-00447-2010.
NR 21
TC 8
Z9 8
U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-8977
J9 IEEE T POWER DELIVER
JI IEEE Trans. Power Deliv.
PD OCT
PY 2011
VL 26
IS 4
BP 2189
EP 2196
DI 10.1109/TPWRD.2011.2159520
PG 8
WC Engineering, Electrical & Electronic
SC Engineering
GA 874TU
UT WOS:000298981800014
ER
PT J
AU Samy, RP
Thwin, MM
Stiles, BG
Bow, H
Chow, VTK
Gopalakrishnakone, P
AF Samy, Ramar Perumal
Thwin, Maung Maung
Stiles, Bradley G.
Bow, Ho
Chow, Vincent T. K.
Gopalakrishnakone, Ponnampalam
TI Therapeutic Potential of Peptides with Neutralizing Ability Towards the
Venom and Toxin (CaTx-I) of Crotalus adamanteus
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Crotalus adamanteus; phospholipase A(2); phospholipase inhibitor;
peptides; snakebite; neutralization
ID PHOSPHOLIPASE A(2) INHIBITORS; IMMUNE FAB OVINE; SNAKE-VENOM;
RATTLESNAKE ENVENOMATION; MYOTOXIN INHIBITOR; BOTHROPS-ASPER;
LYS(49)-PHOSPHOLIPASE A(2); ANTIINFLAMMATORY ACTIVITY;
BIOLOGICAL-PROPERTIES; LIPID-PEROXIDATION
AB The CaTx-I (PLA(2)) toxin of Crotalus adamanteus venom is responsible for most of the symptoms observed during envenomation. Synthetic peptides were designed and screened for venom (0.8 mu g/ml) and CaTx-I (0.1 mu M) inhibition at varying doses of the peptide (10000-0.0001 mu M) using a Cayman chemical human secretory phospholipase A(2) (sPLA(2), Type II) assay kit. Further, in vitro neutralization studies were evaluated by a fixed dose of peptide (1 mu M) against venom (0.8 mu g/ml) and toxin (0.1 mu M). Among the linear peptides (PIP-18, cyclic C and PIP59-67) that showed potent neutralizing effects against the venom/toxin of C. adamanteus. PIP-18 [IC50, 1.23 mu M] and cyclic C [IC50, 1.27 mu M] peptides possessed the strongest inhibitory effect against CaTx-I. A fixed dose of CaTx-I (75 mu g/kg) was administered intraperitoneally (i.p.) into mice followed by an i.p. injection of peptides PIP-18 and cyclic C at (6 mu g/mouse), venom (150 mu g/kg) and toxin CaTx-I alone served as references. Mice treated with PIP-18 and cyclic C showed a very strong neutralizing effect and markedly reduced mortality compared to the control after 24 h. The CA venom and CaTx-I injected mice showed severe toxicity after 24 h. Peptides PIP-18 and cyclic C were non-hemolytic at 100 mu M. They produced a significant decrease in lipid peroxidase (LPx) and enhancement of superoxide dismutase (SOD), catalase (CAT) and Glutathione-s-transferase (GST) levels indicating their antioxidant property against venom-induced changes in mice. This study confirmed the potent snake venom neutralizing properties of peptides.
C1 [Samy, Ramar Perumal; Thwin, Maung Maung; Gopalakrishnakone, Ponnampalam] Natl Univ Singapore, Dept Anat, Yong Loo Lin Sch Med, Venom & Toxin Res Programme, Singapore 117597, Singapore.
[Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA.
[Bow, Ho; Chow, Vincent T. K.] Natl Univ Singapore, Dept Microbiol, Singapore 117597, Singapore.
RP Samy, RP (reprint author), Natl Univ Singapore, Dept Anat, Yong Loo Lin Sch Med, Venom & Toxin Res Programme, Singapore 117597, Singapore.
EM micramar@nus.edu.sg
FU Defence Science and Technology Agency (DSTA) of Singapore [R -181 000
063 422]
FX The authors are grateful to the Defence Science and Technology Agency
(DSTA) of Singapore for financial support (Grant R -181 000 063 422) to
carry out this study.
NR 73
TC 2
Z9 2
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1568-0266
EI 1873-4294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PD OCT
PY 2011
VL 11
IS 20
BP 2540
EP 2555
PG 16
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 871HH
UT WOS:000298728000006
PM 21682682
ER
PT J
AU Helfstein, S
Wright, D
AF Helfstein, Scott
Wright, Dominick
TI Covert or Convenient? Evolution of Terror Attack Networks
SO JOURNAL OF CONFLICT RESOLUTION
LA English
DT Article
DE terrorism; counterterrorism; social network analysis; complex systems
ID DISTRIBUTIONS; GOVERNANCE; KNOWLEDGE; COHESION; LAW
AB The concept of networks has become synonymous with terrorism in recent years. Despite the abundance of material engaging the concept of terrorist networks, there is a paucity of research that applies analytic network methods to the empirical study of observed data. This article fills that void by comparing two arguments about terror network structure using a newly released attack network data set. One account suggests that terrorists purposefully structure their networks to maximize operational security (OPSEC) by minimizing connections, while an alternate proposition relies on findings in network sciences showing that many networks have a few well-connected individuals (referred to as scale-free structure). Empirical analysis of six evolving attack networks produces results contradicting both assertions. This article then looks beyond structure to examine whether there are any causal relationships between network characteristics and output, specifically attack casualties. The article concludes by examining possible drivers of network structure and pertinent policy implications.
C1 [Helfstein, Scott; Wright, Dominick] US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA.
RP Helfstein, S (reprint author), US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA.
EM scott.helfstein@usma.edu
NR 54
TC 10
Z9 10
U1 2
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0027
EI 1552-8766
J9 J CONFLICT RESOLUT
JI J. Confl. Resolut.
PD OCT
PY 2011
VL 55
IS 5
BP 785
EP 813
DI 10.1177/0022002710393919
PG 29
WC International Relations; Political Science
SC International Relations; Government & Law
GA 854FN
UT WOS:000297480500005
ER
PT J
AU Moyer, LR
Spak, J
Lamanna, P
AF Moyer, Lee R.
Spak, Jeffrey
Lamanna, Peter
TI A Multi-Dimensional Hough Transform-Based Track-Before-Detect Technique
for Detecting Weak Targets in Strong Clutter Backgrounds
SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
LA English
DT Article
ID SEARCH RADAR DETECTION; LINES
AB The Hough transform (HT) algorithm detects straight-line features in two-dimensional data. This correspondence extends the HT to N-dimensional data to efficiently combine multiple first-threshold crossings from moving targets. The data dimensions can be the target position, its range and range-rate, and/or the first-threshold crossing times. This multi-dimensional HT (MHT) technique can be applied to enhance the detection of targets in random clutter backgrounds through the application of track-before-detect (TBD) processing.
C1 [Moyer, Lee R.] Technol Serv Corp, Fairfax, VA 22031 USA.
[Spak, Jeffrey; Lamanna, Peter] USA, CERDEC I2WD, Aberdeen Proving Ground, MD 21005 USA.
RP Moyer, LR (reprint author), Technol Serv Corp, 9300 Lee Highway,Suite 500, Fairfax, VA 22031 USA.
EM lee.moyer@tsc.com
NR 16
TC 14
Z9 27
U1 0
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9251
J9 IEEE T AERO ELEC SYS
JI IEEE Trans. Aerosp. Electron. Syst.
PD OCT
PY 2011
VL 47
IS 4
BP 3062
EP 3068
PG 7
WC Engineering, Aerospace; Engineering, Electrical & Electronic;
Telecommunications
SC Engineering; Telecommunications
GA 852FE
UT WOS:000297339000056
ER
PT J
AU Ciezak, JA
AF Ciezak, Jennifer A.
TI The High-Pressure Characterization of Energetic Materials:
1,4-Dimethyl-5-Aminotetrazolium 5-Nitrotetrazolate
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Diamond Anvil Cell; High Nitrogen Content; High Pressure; Energetic
Materials
ID VIBRATIONAL SPECTROSCOPY; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE;
EXPLOSIVES
AB In-situ high-pressure room temperature synchrotron X-ray diffraction and infrared microspectroscopy were used to examine the structural and vibrational properties and the equation of state of 1,4-dimethyl-5-aminotetrazolium 5-nitrotetrazolate (DMATNT). The X-ray measurements show a smoothly varying pressure-volume relationship to 20 GPa. However, the anisotropic ratios of the unit cell parameters reveal a discontinuity near 3.3 GPa, which can be attributed to an irreversible isostructural phase transition. A significant increase in the Infrared spectral intensity near this pressure coupled with Dayvdov splitting of the NO(2) bending and scissoring modes suggest the transition results in a skewing of the NO(2) groups and increasing asymmetry of the hydrogen bonding sublattice.
C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM jciezak@arl.army.mil
FU Office of Science, Office of Basic Energy Sciences, of the U.S.
Department of Energy [DE-AC02-05CH11231, DE-AC02-98CH10886]
FX Portions of this work were performed at the Advanced Light Source which
is supported by the Director, Office of Science, Office of Basic Energy
Sciences, of the U.S. Department of Energy under Contract No.
DE-AC02-05CH11231. Use of the National Synchrotron Light Source,
Brookhaven National Laboratory, was supported by the U.S. Department of
Energy, Office of Science, Office of Basic Energy Sciences, under
Contract No. DE-AC02-98CH10886. The Geophysical Laboratory of the
Carnegie Institution of Washington is thanked for access to their
high-pressure gas loading facility.
NR 20
TC 6
Z9 6
U1 0
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0721-3115
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD OCT
PY 2011
VL 36
IS 5
BP 446
EP 450
DI 10.1002/prep.201100031
PG 5
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA 851UT
UT WOS:000297297200009
ER
PT J
AU Barr, KR
Athrey, G
Lindsay, DL
Lance, RF
Hayden, TJ
Tweddale, SA
Leberg, PL
AF Barr, Kelly R.
Athrey, Giri
Lindsay, Denise L.
Lance, Richard F.
Hayden, Timothy J.
Tweddale, Scott A.
Leberg, Paul L.
TI Missing the forest for the gene trees: Conservation genetics is more
than the identification of distinct population segments
SO AUK
LA English
DT Letter
ID MIGRATION PATTERNS; DIFFERENTIATION; WARBLER; SONGBIRD; DIVERGENCE;
EVOLUTION; MARKERS
C1 [Barr, Kelly R.; Athrey, Giri; Lindsay, Denise L.; Leberg, Paul L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA.
[Barr, Kelly R.] US Geol Survey, Western Ecol Res Ctr, San Diego Field Stn, San Diego, CA 92101 USA.
[Lindsay, Denise L.; Lance, Richard F.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Hayden, Timothy J.; Tweddale, Scott A.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP Barr, KR (reprint author), Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA.
EM kellybarr@gmail.com
RI Athrey, Giridhar/H-4077-2011
OI Athrey, Giridhar/0000-0002-7396-5490
NR 17
TC 2
Z9 2
U1 0
U2 10
PU AMER ORNITHOLOGISTS UNION
PI LAWRENCE
PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 USA
SN 0004-8038
J9 AUK
JI AUK
PD OCT
PY 2011
VL 128
IS 4
BP 792
EP 794
PG 3
WC Ornithology
SC Zoology
GA 859JM
UT WOS:000297872700021
ER
PT J
AU Mancera, AE
Del Rincon, I
Battafarano, DF
Restrepo, JF
Escalante, A
AF Mancera, Antonio E.
Del Rincon, Inmaculada
Battafarano, Daniel F.
Restrepo, Jose Felix
Escalante, Agustin
TI Does the Hispanic Paradox Apply to Mexican Americans With Rheumatoid
Arthritis?
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 75th Annual Scientific Meeting of the
American-College-of-Rheumatology/46th Annual Scientific Meeting of the
Association-of-Rheumatology-Health-Professionals
CY NOV 04-09, 2011
CL Chicago, IL
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Professionals
C1 [Mancera, Antonio E.; Del Rincon, Inmaculada; Restrepo, Jose Felix; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
SU S
MA 111
BP S39
EP S39
PG 1
WC Rheumatology
SC Rheumatology
GA 856EV
UT WOS:000297621500112
ER
PT J
AU Mathew, S
Collamer, AN
Papas, AS
Battafarano, DF
AF Mathew, Stephanie
Collamer, Angelique N.
Papas, Athena S.
Battafarano, Daniel F.
TI Effect of Caphosol (R) On the Symptoms of Xerostomia Associated with
Primary and Secondary Sjogren's Syndrome
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 75th Annual Scientific Meeting of the
American-College-of-Rheumatology/46th Annual Scientific Meeting of the
Association-of-Rheumatology-Health-Professionals
CY NOV 04-09, 2011
CL Chicago, IL
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Professionals
C1 [Mathew, Stephanie] USAF, SAUSHEC, Ft Sam Houston, TX USA.
[Collamer, Angelique N.] Langley AFB Hosp, Langley Afb, VA USA.
[Mathew, Stephanie; Papas, Athena S.] Tufts Sch Dent Med, Boston, MA USA.
[Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
SU S
MA 465
BP S178
EP S179
PG 2
WC Rheumatology
SC Rheumatology
GA 856EV
UT WOS:000297621500465
ER
PT J
AU Restrepo, JF
del Rincon, I
Battafarano, DF
Escalante, A
AF Restrepo, Jose Felix
del Rincon, Inmaculada
Battafarano, Daniel F.
Escalante, Agustin
TI Progression of Joint Damage in a Rheumatoid Arthritis Cohort: Role of
the HLA-DRB1 Shared Epitope
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 75th Annual Scientific Meeting of the
American-College-of-Rheumatology/46th Annual Scientific Meeting of the
Association-of-Rheumatology-Health-Professionals
CY NOV 04-09, 2011
CL Chicago, IL
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Professionals
C1 [Restrepo, Jose Felix; del Rincon, Inmaculada; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
SU S
MA 2142
BP S833
EP S834
PG 2
WC Rheumatology
SC Rheumatology
GA 856EV
UT WOS:000297621502528
ER
PT J
AU Restrepo, JF
Escalante, A
Battafarano, DF
O'Leary, DH
Del Rincon, I
AF Restrepo, Jose Felix
Escalante, Agustin
Battafarano, Daniel F.
O'Leary, Daniel H.
Del Rincon, Inmaculada
TI Radiographic Joint Damage in Rheumatoid Arthritis Is More Strongly
Associated with Peripheral Arterial Stiffness Than with Peripheral or
Carotid Artery Obstruction.
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 75th Annual Scientific Meeting of the
American-College-of-Rheumatology/46th Annual Scientific Meeting of the
Association-of-Rheumatology-Health-Professionals
CY NOV 04-09, 2011
CL Chicago, IL
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Professionals
C1 [Restrepo, Jose Felix; Escalante, Agustin; Del Rincon, Inmaculada] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA.
[O'Leary, Daniel H.] Tufts Univ, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
SU S
MA 1164
BP S453
EP S453
PG 1
WC Rheumatology
SC Rheumatology
GA 856EV
UT WOS:000297621501358
ER
PT J
AU Roberts, JR
Edison, JD
Mewshaw, EA
Mikita, J
AF Roberts, Jefferson R.
Edison, Jess D.
Mewshaw, Elizabeth A.
Mikita, Jeffrey
TI Effects of Simulated Joint Aspiration Training on Self-Confidence.
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 75th Annual Scientific Meeting of the
American-College-of-Rheumatology/46th Annual Scientific Meeting of the
Association-of-Rheumatology-Health-Professionals
CY NOV 04-09, 2011
CL Chicago, IL
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Professionals
C1 [Roberts, Jefferson R.] Walter Reed Army Med Ctr, Chevy Chase, MD USA.
[Edison, Jess D.; Mewshaw, Elizabeth A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
SU S
MA 89
BP S30
EP S31
PG 2
WC Rheumatology
SC Rheumatology
GA 856EV
UT WOS:000297621500090
ER
PT J
AU Cho, JH
Chen, IR
AF Cho, Jin-Hee
Chen, Ing-Ray
TI Model-Based Evaluation of Distributed Intrusion Detection Protocols for
Mobile Group Communication Systems
SO WIRELESS PERSONAL COMMUNICATIONS
LA English
DT Article
DE Model-based evaluation; Intrusion detection; Key management; Group
communication systems; Mean time to security failure; False positives;
False negatives; Mobile ad hoc networks
ID AD HOC NETWORKS; SENSOR NETWORKS; SECURITY
AB Under highly security vulnerable, resource-restricted, and dynamically changing mobile ad hoc environments, it is critical to be able to maximize the system lifetime while bounding the communication response time for mission-oriented mobile groups. In this paper, we analyze the tradeoff of security versus performance for distributed intrusion detection protocols employed in mobile group communication systems (GCSs). We investigate a distributed voting-based intrusion detection protocol for GCSs in multi-hop mobile ad hoc networks and examine the effect of intrusion detection on system survivability measured by the mean time to security failure (MTTSF) metric and efficiency measured by the communication cost metric. We identify optimal design settings under which the MTTSF metric can be best traded off for the communication cost metric or vice versa. We conduct extensive simulation to validate analytical results obtained. This work provides a general model-based evaluation framework for developing and analyzing intrusion detection protocols that can dynamically adapt to changing attacker strengths with the goal of system lifetime optimization and/or communication cost minimization.
C1 [Cho, Jin-Hee] USA, CISD, Res Lab USARL, Adelphi, MD 20783 USA.
[Chen, Ing-Ray] Virginia Polytech Inst & State Univ, Dept Comp Sci, Falls Church, VA 22043 USA.
RP Cho, JH (reprint author), USA, CISD, Res Lab USARL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jinhee.cho@us.army.mil; irchen@vt.edu
NR 42
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0929-6212
J9 WIRELESS PERS COMMUN
JI Wirel. Pers. Commun.
PD OCT
PY 2011
VL 60
IS 4
BP 725
EP 750
DI 10.1007/s11277-010-9971-1
PG 26
WC Telecommunications
SC Telecommunications
GA 852JI
UT WOS:000297353500011
ER
PT J
AU Stark, TD
Lewis, JR
Castro, G
Walberg, FC
Mathews, DL
AF Stark, Timothy D.
Lewis, Justin R.
Castro, Gonzalo
Walberg, Francke C.
Mathews, David L.
TI Liquefaction subsurface investigation for Milford Dam
SO CANADIAN GEOTECHNICAL JOURNAL
LA English
DT Article
DE soil mechanics; liquefaction; shear strength; cone penetration test;
standard penetration test; seismic stability
ID UNDRAINED SHEAR-STRENGTH; SANDS
AB The US Army Corps of Engineers (USACE) completed a liquefaction potential analysis as part of the seismic evaluation of Milford Dam in 1986. This paper uses data from the 1986 study to compare fines content data from in situ frozen and standard penetration test (SPT) samples that suggest fines content can be overestimated by 1-10% by SPT samples in stratified sand deposits. This result may have implications for liquefaction assessments because split-spoon samples may overestimate the actual fines content, resulting in a liquefiable deposit being classified as nonliquefiable. In addition, the paper evaluates the effectiveness of ground freezing on maintaining in situ soil structure and aging of the foundation sands at Milford Dam.
C1 [Stark, Timothy D.] Univ Illinois, Urbana, IL 61801 USA.
[Lewis, Justin R.] Hayward Baker, Roselle, IL 60172 USA.
[Castro, Gonzalo] GEI Consultants Inc, Woburn, MA 01801 USA.
[Walberg, Francke C.] URS Corp, Overland Pk, KS 66210 USA.
[Mathews, David L.] USA, Corps Engineers, Geotech Branch, Kansas City, MO 64106 USA.
RP Stark, TD (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA.
EM tstark@illinois.edu
NR 33
TC 2
Z9 2
U1 0
U2 2
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-3674
J9 CAN GEOTECH J
JI Can. Geotech. J.
PD OCT
PY 2011
VL 48
IS 10
BP 1504
EP 1519
DI 10.1139/T11-055
PG 16
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA 847QO
UT WOS:000296987800006
ER
PT J
AU Warner, DH
Mathaudhu, SN
AF Warner, D. H.
Mathaudhu, S. N.
TI Influence of Microcracking on Shear Localization
SO JOURNAL OF ENGINEERING MECHANICS
LA English
DT Article
DE Microcracking; Shear banding; Shear localization; Micromechanics;
Finite-element modeling
ID DUCTILE TRANSITION; TUNGSTEN; COMPRESSION; FRACTURE
AB This work examines the influence of microcracking on a material's tendency to shear localize under compressive loading. A two-dimensional (2D) finite-element framework with explicit crack representation using cohesive-element methodologies is employed. The influence of microcracking is examined by taking the fracture toughness of the cohesive elements as a free parameter. The simulations suggest that an optimum fracture toughness exists for promoting shear localization. This value corresponds to the limiting mode I fracture toughness, below which microscopic material defects lead to brittle compressive failure, as opposed to shear localization. While in the presence of confinement, this value is shown to be close to zero; in the absence of confinement, it is computed to be 28% of the shear band toughness for the specific case of ultrafine-grained tungsten. More generally, it is found that the ratio of mode I fracture toughness to shear band toughness provides a crude indicator for predicting whether material defects are likely to lead to brittle failure or enhanced shear localization. DOI: 10.1061/(ASCE)EM.1943-7889.0000269. (C) 2011 American Society of Civil Engineers.
C1 [Warner, D. H.] Cornell Univ, Sch Civil & Environm Engn, Ithaca, NY 14853 USA.
[Mathaudhu, S. N.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
RP Warner, DH (reprint author), Cornell Univ, Sch Civil & Environm Engn, Ithaca, NY 14853 USA.
EM dhw52@cornell.edu
RI Warner, Derek/A-2303-2012; Mathaudhu, Suveen/B-4192-2009
FU Ordnance Materials Branch of the United States Army Research Laboratory
[W911 NF-07-D-0001]
FX This work was supported by the Ordnance Materials Branch of the United
States Army Research Laboratory under Contract No. W911 NF-07-D-0001.
NR 27
TC 0
Z9 0
U1 0
U2 8
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9399
EI 1943-7889
J9 J ENG MECH
JI J. Eng. Mech.
PD OCT
PY 2011
VL 137
IS 10
BP 691
EP 698
DI 10.1061/(ASCE)EM.1943-7889.0000269
PG 8
WC Engineering, Mechanical
SC Engineering
GA 841JS
UT WOS:000296509200006
ER
PT J
AU Goff, A
Mucker, E
Raymond, J
Fisher, R
Bray, M
Hensley, L
Paragas, J
AF Goff, Arthur
Mucker, Eric
Raymond, Jolynne
Fisher, Robert
Bray, Mike
Hensley, Lisa
Paragas, Jason
TI Infection of cynomolgus macaques with a recombinant monkeypox virus
encoding green fluorescent protein
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID VACCINIA VIRUS; SMALLPOX; EFFICACY; ASSAY
AB Monkeypox virus (MPXV) causes a vesiculopustular rash illness resembling smallpox in humans and produces a similar disease in nonhuman primates. To enhance the ability of researchers to study experimental MPXV infections, we inserted a gene encoding green fluorescent protein (GFP) into Monkeypox virus Zaire-79. Wild-type and MPXV-GFP replicated with similar kinetics in cell culture and caused a similar disease when injected intravenously into cynomolgus macaques. In MPXV-GFP-infected animals, examination under fluorescent light facilitated the identification of skin lesions during disease development and internal sites of replication at necropsy. MPXV-GFP could improve the quantitative assessment of antiviral therapy and vaccine efficacy.
C1 [Goff, Arthur; Mucker, Eric; Hensley, Lisa] USA, Div Virol, Viral Therapeut Branch, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Raymond, Jolynne] Armed Forces Inst Pathol, Silver Spring, MD USA.
[Fisher, Robert] US FDA, Lab Plasma Derivat, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
[Bray, Mike; Paragas, Jason] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD 21702 USA.
RP Goff, A (reprint author), USA, Div Virol, Viral Therapeut Branch, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM arthur.goff@amedd.army.mil
FU Defense Threat Reduction Agency; Department of Homeland Security's
National Biodefense Analysis and Countermeasures Center (NBACC)
FX The research described in this paper was funded by the Defense Threat
Reduction Agency and The Department of Homeland Security's National
Biodefense Analysis and Countermeasures Center (NBACC). Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the U.S. Army.
NR 12
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
J9 ARCH VIROL
JI Arch. Virol.
PD OCT
PY 2011
VL 156
IS 10
BP 1877
EP 1881
DI 10.1007/s00705-011-1065-1
PG 5
WC Virology
SC Virology
GA 841KC
UT WOS:000296510200022
PM 21814864
ER
PT J
AU Sorooshian, S
AghaKouchak, A
Arkin, P
Eylander, J
Foufoula-Georgiou, E
Harmon, R
Hendrickx, JMH
Imam, B
Kuligowski, R
Skahill, B
Skofronick-Jackson, G
AF Sorooshian, Soroosh
AghaKouchak, Amir
Arkin, Phillip
Eylander, John
Foufoula-Georgiou, Efi
Harmon, Russell
Hendrickx, Jan M. H.
Imam, Bisher
Kuligowski, Robert
Skahill, Brian
Skofronick-Jackson, Gail
TI ADVANCING THE REMOTE SENSING OF PRECIPITATION
SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
LA English
DT Article
C1 [AghaKouchak, Amir] Univ Calif Irvine, Dept Civil & Environm Engn, Irvine, CA 92717 USA.
[Arkin, Phillip] Univ Maryland, College Pk, MD 20742 USA.
[Eylander, John] USA, Engineer Res & Dev Ctr, Hanover, NH USA.
[Foufoula-Georgiou, Efi] Univ Minnesota, Minneapolis, MN USA.
[Harmon, Russell] USA, Res Lab, Durham, NC USA.
[Hendrickx, Jan M. H.] New Mexico Inst Min & Technol, Socorro, NM USA.
[Kuligowski, Robert] NOAA, NESDIS, STAR, Camp Springs, MD USA.
[Skahill, Brian] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Skofronick-Jackson, Gail] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
RP AghaKouchak, A (reprint author), Univ Calif Irvine, Dept Civil & Environm Engn, Irvine, CA 92717 USA.
EM amir.a@uci.edu
RI sorooshian, soroosh/B-3753-2008; Skofronick-Jackson, Gail/D-5354-2012;
Kuligowski, Robert/C-6981-2009
OI sorooshian, soroosh/0000-0001-7774-5113; Kuligowski,
Robert/0000-0002-6909-2252
FU U.S. Army Research Office
FX We are pleased to acknowledge that the funding for the Advanced Concepts
Workshop on Remote Sensing of Precipitation was provided by the U.S.
Army Research Office.
NR 0
TC 13
Z9 13
U1 0
U2 16
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0003-0007
J9 B AM METEOROL SOC
JI Bull. Amer. Meteorol. Soc.
PD OCT
PY 2011
VL 92
IS 10
BP 1271
EP 1272
DI 10.1175/BAMS-D-11-00116.1
PG 2
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 848UI
UT WOS:000297080200006
ER
PT J
AU Sorooshian, S
AghaKouchak, A
Arkin, P
Eylander, J
Foufoula-Georgiou, E
Harmon, R
Hendrickx, JMH
Imam, B
Kuligowski, R
Skahill, B
Skofronick-Jackson, G
AF Sorooshian, Soroosh
AghaKouchak, Amir
Arkin, Phillip
Eylander, John
Foufoula-Georgiou, Efi
Harmon, Russell
Hendrickx, Jan M. H.
Imam, Bisher
Kuligowski, Robert
Skahill, Brian
Skofronick-Jackson, Gail
TI ADVANCED CONCEPTS ON REMOTE SENSING OF PRECIPITATION AT MULTIPLE SCALES
SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
LA English
DT Article
ID PASSIVE MICROWAVE; RAINFALL; SYSTEM
C1 [Sorooshian, Soroosh] Univ Calif Irvine, Dept Civil & Environm Engn, Irvine, CA 92697 USA.
[Arkin, Phillip] Univ Maryland, College Pk, MD 20742 USA.
[Eylander, John] USA, Engineer Res & Dev Ctr, Hanover, NH USA.
[Foufoula-Georgiou, Efi] Univ Minnesota, Minneapolis, MN USA.
[Harmon, Russell] USA, Res Lab, Durham, NC USA.
[Hendrickx, Jan M. H.] New Mexico Inst Min & Technol, Socorro, NM USA.
[Kuligowski, Robert] NOAA, NESDIS, STAR, Camp Springs, MD USA.
[Skahill, Brian] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Skofronick-Jackson, Gail] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
RP Sorooshian, S (reprint author), Univ Calif Irvine, Dept Civil & Environm Engn, Irvine, CA 92697 USA.
EM soroosh@uci.edu
RI Skofronick-Jackson, Gail/D-5354-2012; sorooshian, soroosh/B-3753-2008;
Kuligowski, Robert/C-6981-2009
OI sorooshian, soroosh/0000-0001-7774-5113; Kuligowski,
Robert/0000-0002-6909-2252
FU U.S. Army Research Office
FX We are pleased to acknowledge that a major portion of the funding for
this workshop was provided by the U.S. Army Research Office. Our deepest
gratitude goes to Dr. Russell Harmon for his unyielding support
throughout the planning and organization of the workshop. We offer
special thanks to Diane Hohnbaum for organizing and coordinating the
workshop activities. Finally, we are very thankful to CHRS graduate
students Jingjing Li, Rebeka Sultana, Qing Xia, Ali Zahraei, Tsou Chun
Jaw, Nasrin Nasrollahi, and Hamed Ashouri, who offered so generously
their time summarizing group discussions throughout the workshop. The
contents of this article are solely the opinions of the authors and do
not constitute a statement of policy, decision, or position on behalf of
the U.S. Army, NOAA, NASA, or the U.S. government.
NR 13
TC 56
Z9 57
U1 3
U2 17
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0003-0007
J9 B AM METEOROL SOC
JI Bull. Amer. Meteorol. Soc.
PD OCT
PY 2011
VL 92
IS 10
BP 1353
EP 1357
DI 10.1175/2011BAMS3158.1
PG 5
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 848UI
UT WOS:000297080200017
ER
PT J
AU Alexander, MJ
Allison, JT
Papalambros, PY
Gorsich, DJ
AF Alexander, Michael J.
Allison, James T.
Papalambros, Panos Y.
Gorsich, David J.
TI Constraint Management of Reduced Representation Variables in
Decomposition-Based Design Optimization
SO JOURNAL OF MECHANICAL DESIGN
LA English
DT Article
DE decomposition-based design optimization; reduced representation;
constraint management; support vector domain description
ID COHERENT STRUCTURES; TURBULENCE; DYNAMICS
AB In decomposition-based design optimization strategies such as analytical target cascading (ATC), it is sometimes necessary to use reduced representations of highly discretized functional data exchanged among subproblems to enable efficient design optimization. However, the variables used by such reduced representation methods are often abstract, making it difficult to constrain them directly beyond simple bounds. This problem is usually addressed by implementing a penalty value-based heuristic that indirectly constrains the reduced representation variables. Although this approach is effective, it leads to many ATC iterations, which in turn yields an ill-conditioned optimization problem and an extensive runtime. To address these issues, this paper introduces a direct constraint management technique that augments the penalty value-based heuristic with constraints generated by support vector domain description (SVDD). A comparative ATC study between the existing and proposed constraint management methods involving electric vehicle design indicates that the SVDD augmentation is the most appropriate within decomposition-based design optimization. [DOI: 10.1115/1.4004976]
C1 [Alexander, Michael J.] Gen Motors Tech Ctr, Prop Syst Res Lab, Warren, MI 48090 USA.
[Allison, James T.] Univ Illinois, Dept Ind & Enterprise Syst Engn, Urbana, IL 61801 USA.
[Papalambros, Panos Y.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48104 USA.
[Gorsich, David J.] USA, TARDEC, Warren, MI 48397 USA.
RP Alexander, MJ (reprint author), Gen Motors Tech Ctr, Prop Syst Res Lab, 330500 Mound Rd, Warren, MI 48090 USA.
EM michael.j.alexander@gm.com; jtalliso@illinois.edu; pyp@umich.edu;
david.j.gorsich.civ@mail.mil
FU Automotive Research Center; Automotive Research Center, a U.S. Army
RDECOM Center of Excellence headquartered at the University of Michigan
FX This research has been partially supported by the Automotive Research
Center, a U.S. Army RDECOM Center of Excellence headquartered at the
University of Michigan. This support is gratefully acknowledged.
NR 32
TC 6
Z9 6
U1 0
U2 3
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1050-0472
J9 J MECH DESIGN
JI J. Mech. Des.
PD OCT
PY 2011
VL 133
IS 10
AR 101014
DI 10.1115/1.4004976
PG 10
WC Engineering, Mechanical
SC Engineering
GA 841IN
UT WOS:000296506100016
ER
PT J
AU Choi, S
Datta, A
Alonso, JJ
AF Choi, Seongim
Datta, Anubhav
Alonso, Juan J.
TI Prediction of Helicopter Rotor Loads Using Time-Spectral Computational
Fluid Dynamics and an Exact Fluid-Structure Interface
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
ID VALIDATION; DISCRETIZATION; FLOWS
AB The objectives of this paper are to introduce time-spectral computational fluid dynamics (CFD) for the analysis of helicopter rotor flows in level flight and to introduce an exact fluid-structure interface for coupled CFD/computational structural dynamics (CSD) analysis. The accuracy and efficiency of time-spectral CFD are compared with conventional time-marching computations. The exact interface is equipped with an exact delta coupling procedure that bypasses the requirement for sectional airloads. Predicted loads are compared between time-spectral and time-marching CFD using both interfaces and validated using UH-60A flight data for high-vibration and dynamic stall conditions. It is concluded that time-spectral CFD can indeed predict rotor performance and peak-to-peak structural loads efficiently, and hence, open opportunity for blade shape optimization. The vibratory and dynamic stall loads, however, require a large number of time instances, which reduces its efficiency. The exact interface and delta procedure allow coupling to be implemented for arbitrary grids and advanced structural models exactly, without the requirement for two-dimensional sectional airloads.
C1 [Choi, Seongim; Alonso, Juan J.] Stanford Univ, Dept Aeronaut & Astronaut, Stanford, CA 94305 USA.
[Datta, Anubhav] USA, Sci & Technol Corp, Aeroflightdynam Directorate, NASA Ames Res Ctr, Moffett Field, CA USA.
RP Choi, S (reprint author), Korea Adv Inst Sci & Technol, Dept Aerosp Engn, Taejon 305701, South Korea.
EM schoi1@kaist.ac.kr
RI Choi, Seongim/C-1825-2011
FU U.S. DoD HPC Modernization Program Office
FX This research was conducted at the U.S. Army Aeroflightdynamics
Directorate as part of the High Performance Computing Institute of
Advanced Rotorcraft Modeling and Simulation (HI-ARMS) program supported
by the U.S. DoD HPC Modernization Program Office and directed by Dr.
Roger Strawn. The authors wish to thank Wayne Johnson (NASA Ames) for
his insightful comments and discussions.
NR 29
TC 3
Z9 3
U1 0
U2 0
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
EI 2161-6027
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD OCT
PY 2011
VL 56
IS 4
AR 042001
DI 10.4050/JAHS.56.042001
PG 15
WC Engineering, Aerospace
SC Engineering
GA 846OC
UT WOS:000296912100001
ER
PT J
AU Yeo, H
Potsdam, M
Ormiston, RA
AF Yeo, Hyeonsoo
Potsdam, Mark
Ormiston, Robert A.
TI Rotor Aeroelastic Stability Analysis Using Coupled Computational Fluid
Dynamics/Computational Structural Dynamics
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
AB Computational fluid dynamics/computational structural dynamics (CFD/CSD) coupling was successfully applied to the rotor aeroelastic stability problem to calculate lead-lag regressing mode damping of a hingeless rotor in hover and forward flight. A direct time domain numerical integration of the equations in response to suitable excitation was solved using a tight CFD/CSD coupling. Two different excitation methods-swashplate cyclic pitch and blade tip lead-lag force excitations-were investigated to provide suitable blade transient responses. The free decay transient response time histories were postprocessed using the moving-block method to determine the damping as a function of the rotor operating conditions. Coupled CFD/CSD analysis results are compared with the experimentally measured stability data obtained for a 7.5-ft-diameter Mach-scale hingeless rotor model as well as stability predictions using the comprehensive analysis Rotorcraft Comprehensive Analysis System (RCAS). The coupled CFD/CSD predictions agreed more closely with the experimental lead-lag damping measurements than RCAS predictions based on conventional aerodynamic methods, better capturing key features in the damping trends.
C1 [Yeo, Hyeonsoo; Potsdam, Mark; Ormiston, Robert A.] USA, Aeroflightdynam Directorate AMRDEC, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA.
RP Yeo, H (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA.
EM hyeonsoo.yeo@us.army.mil
NR 26
TC 1
Z9 1
U1 0
U2 0
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD OCT
PY 2011
VL 56
IS 4
AR 042003
DI 10.4050/JAHS.56.042003
PG 16
WC Engineering, Aerospace
SC Engineering
GA 846OC
UT WOS:000296912100003
ER
PT J
AU Yeo, H
Romander, EA
Norman, TR
AF Yeo, Hyeonsoo
Romander, Ethan A.
Norman, Thomas R.
TI Investigation of Rotor Performance and Loads of a UH-60A Individual
Blade Control System
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
ID COMPREHENSIVE ANALYSIS; ACTIVE CONTROLS; ENHANCEMENT; PREDICTION;
HELICOPTER; AIRLOADS
AB Wind tunnel measurements of performance, loads, and vibration of a full-scale UH-60A Black Hawk main rotor with an individual blade control (IBC) system are compared with calculations obtained using the comprehensive helicopter analysis CAMRAD II and a coupled CAMRAD II/OVERFLOW 2 analysis. Measured data show a 5.1% rotor power reduction (8.6% rotor lift to effective-drag ratio increase) using 2/rev IBC actuation with 2.0. amplitude at mu = 0.4. At the optimum IBC phase for rotor performance, IBC actuator force (pitch link force) decreased, and neither flap nor chord bending moments changed significantly. CAMRAD II predicts the rotor power variations with the IBC phase reasonably well at mu = 0.35. However, the correlation degrades at mu = 0.4. Coupled CAMRAD II/OVERFLOW 2 shows excellent correlation with the measured rotor power variations with the IBC phase at both mu = 0.35 and mu = 0.4. Maximum reduction of IBC actuator force is better predicted with CAMRAD II, but general trends are better captured with the coupled analysis. The correlation of vibratory hub loads is generally poor by both methods, although the coupled analysis somewhat captures general trends.
C1 [Yeo, Hyeonsoo] USA, Aeroflightdynam Directorate AMRDEC, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA.
[Romander, Ethan A.; Norman, Thomas R.] Natl Aeronaut & Space Adm, Flight Vehicle Res & Technol Div, Ames Res Ctr, Moffett Field, CA USA.
RP Yeo, H (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA.
EM hyeonsoo.yeo@us.army.mil
NR 29
TC 4
Z9 4
U1 0
U2 3
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD OCT
PY 2011
VL 56
IS 4
AR 042006
DI 10.4050/JAHS.56.042006
PG 18
WC Engineering, Aerospace
SC Engineering
GA 846OC
UT WOS:000296912100006
ER
PT J
AU Anderson, KB
Gibbons, RV
Thomas, SJ
Rothman, AL
Nisalak, A
Berkelman, RL
Libraty, DH
Endy, TP
AF Anderson, Kathryn B.
Gibbons, Robert V.
Thomas, Stephen J.
Rothman, Alan L.
Nisalak, Ananda
Berkelman, Ruth L.
Libraty, Daniel H.
Endy, Timothy P.
TI Preexisting Japanese Encephalitis Virus Neutralizing Antibodies and
Increased Symptomatic Dengue Illness in a School-Based Cohort in
Thailand
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID WEST-NILE-VIRUS; CROSS-PROTECTION; KAMPHAENG-PHET; HEMORRHAGIC-FEVER;
ST-LOUIS; INFECTION; VACCINE; IMMUNIZATION; EPIDEMIOLOGY; ENHANCEMENT
AB Background: Dengue viruses (DENVs) and Japanese encephalitis virus (JEV) have significant cross-reactivity in serological assays; the clinical implications of this remain undefined. An improved understanding of whether and how JEV immunity modulates the clinical outcome of DENV infection is important as large-scale DENV vaccine trials will commence in areas where JEV is co-endemic and/or JEV immunization is routine.
Methods and Findings: The association between preexisting JEV neutralizing antibodies (NAbs) and the clinical severity of DENV infection was evaluated in a prospective school-based cohort in Thailand that captured asymptomatic, non-hospitalized, and hospitalized DENV infections. Covariates considered included age, baseline DENV antibody status, school of attendance, epidemic year, and infecting DENV serotype. 942 children experienced at least one DENV infection between 1998 and 2002, out of 3,687 children who were enrolled for at least one full year. In crude analysis, the presence of JEV NAbs was associated with an increased occurrence of symptomatic versus asymptomatic infection (odds ratio [OR] = 1.55, 95% CI: 1.08-2.23) but not hospitalized illness or dengue hemorrhagic fever (DHF). The association was strongest in children with negative DENV serology (DENV-naive) (OR = 2.75, 95% CI: 1.12-6.72), for whom the presence of JEV NAbs was also associated with a symptomatic illness of longer duration (5.4 days for JEV NAb+ versus 2.6 days for JEV NAb-, p = 0.048). JEV NAbs were associated with increased DHF in younger children with multitypic DENV NAb profiles (OR = 4.05, 95% CI: 1.18 to 13.87). Among those with JEV NAbs, the association with symptomatic illness did not vary by antibody titer.
Interpretation: The prior existence of JEV NAbs was associated with an increased probability of symptomatic as compared to asymptomatic DENV illness. These findings are in contrast to previous studies suggesting an attenuating effect of heterologous flavivirus immunity on DENV disease severity.
C1 [Anderson, Kathryn B.; Berkelman, Ruth L.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Gibbons, Robert V.; Thomas, Stephen J.; Nisalak, Ananda; Endy, Timothy P.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Rothman, Alan L.; Libraty, Daniel H.] Univ Massachusetts, Sch Med, Worcester, MA USA.
RP Anderson, KB (reprint author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
EM kbander@learnlink.emory.edu
FU Centers for Disease Control and Prevention (CDC) [1R36CK00104]; National
Institutes of Health (NIH) [P01 AI34533]; United States Army Medical
Research and Materiel Command, Fort Detrick, Maryland, USA
FX This project and publication were made possible by Dissertation Grant
1R36CK00104 from the Centers for Disease Control and Prevention (CDC),
National Institutes of Health (NIH) Grant P01 AI34533, and the United
States Army Medical Research and Materiel Command, Fort Detrick,
Maryland, USA. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 42
TC 27
Z9 27
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2011
VL 5
IS 10
AR e1311
DI 10.1371/journal.pntd.0001311
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 842FR
UT WOS:000296579700007
PM 21991398
ER
PT J
AU Radowsky, JS
Strawn, AA
Sherwood, J
Braden, A
Liston, W
AF Radowsky, Jason S.
Strawn, Alan A.
Sherwood, Jeffrey
Braden, Adam
Liston, William
TI Invasive Mucormycosis and Aspergillosis in a Healthy 22-Year-Old Battle
Casualty: Case Report
SO SURGICAL INFECTIONS
LA English
DT Article
ID OF-THE-LITERATURE; ZYGOMYCOSIS; PATIENT
AB Background: Invasive mucormycosis or aspergillosis is a life-threatening infection. The disease typically occurs in immunocompromised patients (e. g., those with diabetes mellitus or burns) but is rarely serious in otherwise-healthy young trauma patients.
Methods: Case report and literature review.
Results: A previously-healthy 22-year-old United States Marine who sustained large soft tissue injuries in support of Operation Enduring Freedom underwent multiple operations in theater to stabilize his wounds. He was evacuated first to Landstuhl Regional Medical Center in Germany and thence to the National Naval Medical Center in Maryland, where appropriate antifungal therapies were initiated and wide debridements were undertaken without success. His clinical status deteriorated, and he died. Tissue examination revealed systemic invasive mucormycosis and aspergillosis.
Conclusion: The suspicion of invasive fungal infections must be tested early if intervention is to be curative.
C1 [Radowsky, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Sherwood, Jeffrey] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA.
[Strawn, Alan A.; Liston, William] Natl Naval Med Ctr, Dept Gen Surg, Bethesda, MD USA.
[Braden, Adam; Liston, William] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Radowsky, JS (reprint author), Walter Reed Natl Mil Med Ctr, Dept Surg, 8901 Rockville Pike, Bethesda, MD 20889 USA.
EM jason.radowsky@us.army.mil
NR 14
TC 13
Z9 13
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2011
VL 12
IS 5
BP 397
EP 400
DI 10.1089/sur.2010.065
PG 4
WC Infectious Diseases; Surgery
SC Infectious Diseases; Surgery
GA 846MB
UT WOS:000296905900012
PM 22004440
ER
PT J
AU Chen, Y
Nasrabadi, NM
Tran, TD
AF Chen, Yi
Nasrabadi, Nasser M.
Tran, Trac D.
TI Hyperspectral Image Classification Using Dictionary-Based Sparse
Representation
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Classification; hyperspectral imagery; joint sparsity model;
simultaneous sparse recovery; sparse representation; spatial correlation
ID LINEAR INVERSE PROBLEMS; REMOTE-SENSING IMAGES; SIGNAL RECONSTRUCTION;
BASIS PURSUIT; ALGORITHMS; APPROXIMATION; SUPPORT; DECOMPOSITION;
RECOGNITION; MACHINES
AB A new sparsity-based algorithm for the classification of hyperspectral imagery is proposed in this paper. The proposed algorithm relies on the observation that a hyperspectral pixel can be sparsely represented by a linear combination of a few training samples from a structured dictionary. The sparse representation of an unknown pixel is expressed as a sparse vector whose nonzero entries correspond to the weights of the selected training samples. The sparse vector is recovered by solving a sparsity-constrained optimization problem, and it can directly determine the class label of the test sample. Two different approaches are proposed to incorporate the contextual information into the sparse recovery optimization problem in order to improve the classification performance. In the first approach, an explicit smoothing constraint is imposed on the problem formulation by forcing the vector Laplacian of the reconstructed image to become zero. In this approach, the reconstructed pixel of interest has similar spectral characteristics to its four nearest neighbors. The second approach is via a joint sparsity model where hyperspectral pixels in a small neighborhood around the test pixel are simultaneously represented by linear combinations of a few common training samples, which are weighted with a different set of coefficients for each pixel. The proposed sparsity-based algorithm is applied to several real hyperspectral images for classification. Experimental results show that our algorithm outperforms the classical supervised classifier support vector machines in most cases.
C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
[Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
EM ychen98@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu
RI anzhi, yue/A-8609-2012
FU ARO [58110-MA-II]; NSF [CCF-0728893]
FX This work is supported in part by ARO Grant 58110-MA-II and in part by
NSF Grant CCF-0728893.
NR 60
TC 299
Z9 329
U1 9
U2 72
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD OCT
PY 2011
VL 49
IS 10
BP 3973
EP 3985
DI 10.1109/TGRS.2011.2129595
PN 2
PG 13
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 846HY
UT WOS:000296889000013
ER
PT J
AU King, JK
Blanton, JO
AF King, Jeffrey K.
Blanton, Jackson O.
TI Model for Predicting Effects of Land-Use Changes on the Canal-Mediated
Discharge of Total Suspended Solids into Tidal Creeks and Estuaries
SO JOURNAL OF ENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Land use; Hydrologic models; Water pollution; Water resources; Suspended
solids; GIS
ID NUTRIENTS; LANDSCAPE; SEDIMENTS; QUALITY; METALS
AB The Land Use Input Canal Output Model (LUICOM) was created for the purpose of predicting canal-mediated, total suspended solids (TSS) loading in receiving estuaries. Tidal flushing (related to the tidal prism) within a subject estuary (i.e., Yellow Bluff Creek) was also evaluated. Estimates of flushing times were based on those estimated for Georgia and South Carolina creeks that have better coverage of hypsometric data. Two rain events were sampled for this effort, and TSS concentrations predicted by LUICOM compared favorably with observed values. With subsidence of each rain event, TSS concentrations gradually decreased to baseline concentration in the receiving estuary. Moreover, LUICOM provided a reasonable estimate of the time of peak TSS. The results of this study suggest that TSS measured in the subject canal and creek increase as the result of significant rain events (> 1.0 in. in 3 h). The correlation between model-derived and measured TSS values suggest LUICOM could be used to evaluate changes in a basin's land use as it relates to predicting subsequent increases in TSS discharges. The simplicity of the model makes it an ideal tool for resource managers concerned with changes in land use within coastal areas. DOI: 10.1061/(ASCE)EE.1943-7870.0000396. (C) 2011 American Society of Civil Engineers.
C1 [King, Jeffrey K.] Natl Ocean & Atmospher Adm, Natl Ctr Coastal Ocean Sci, Ctr Human Hlth Risk, Hollings Marine Lab, Charleston, SC 29412 USA.
[King, Jeffrey K.; Blanton, Jackson O.] Skidaway Inst Oceanog, Savannah, GA 31419 USA.
[King, Jeffrey K.] USA, Corps Engineers, Savannah, GA 31402 USA.
RP King, JK (reprint author), Natl Ocean & Atmospher Adm, Natl Ctr Coastal Ocean Sci, Ctr Human Hlth Risk, Hollings Marine Lab, 331 Ft Johnson Rd, Charleston, SC 29412 USA.
EM jeff.king@noaa.gov
NR 28
TC 4
Z9 4
U1 1
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9372
EI 1943-7870
J9 J ENVIRON ENG
JI J. Environ. Eng.-ASCE
PD OCT
PY 2011
VL 137
IS 10
BP 920
EP 927
DI 10.1061/(ASCE)EE.1943-7870.0000396
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 841LH
UT WOS:000296513300007
ER
PT J
AU Kamnaksh, A
Kovesdi, E
Kwon, SK
Wingo, D
Ahmed, F
Grunberg, NE
Long, J
Agoston, DV
AF Kamnaksh, Alaa
Kovesdi, Erzsebet
Kwon, Sook-Kyung
Wingo, Daniel
Ahmed, Farid
Grunberg, Neil E.
Long, Joseph
Agoston, Denes V.
TI Factors Affecting Blast Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE behavior; inflammation; traumatic brain injury
ID POSTTRAUMATIC-STRESS-DISORDER; INDUCED NEUROTRAUMA; CEREBRAL-ISCHEMIA;
INFLAMMATION; NEUROPROTECTION; MECHANISMS; EXPRESSION; CYTOKINES;
EXPOSURE; IMMUNE
AB The overlapping pathologies and functional outcomes of blast-induced TBI (bTBI) and stress-related neurobehavioral disorders like post-traumatic stress disorder (PTSD) are significant military health issues. Soldiers are exposed to multiple stressors with or without suffering bTBI, making diagnosis and treatment as well as experimental modeling of bTBI a challenge. In this study we compared anxiety levels of Naive rats to ones that were exposed to each of the following conditions daily for 4 consecutive days: C I: transportation alone; C II: transportation and anesthesia; C III: transportation, anesthesia, and blast sounds; Injured: all three variables plus mild blast overpressure. Following behavioral testing we analyzed sera and select brain regions for protein markers and cellular changes. C I, C II, and C III animals exhibited increased anxiety, but serum corticosterone levels were only significantly elevated in C III and Injured rats. C III and Injured animals also had elevated interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) levels in the amygdala (AD) and ventral hippocampus (VHC). Glial fibrillary acidic protein (GFAP) levels were only significantly elevated in the VHC, prefrontal cortex (PFC), and AD of Injured animals; they showed an apparent increase in ionized calcium-binding adapter molecule (Iba1) and GFAP immunoreactivity, as well as increased numbers of TUNEL-positive cells in the VHC. Our findings demonstrate that experimental conditions, particularly the exposure to blast acoustics, can increase anxiety and trigger specific behavioral and molecular changes without injury. These findings should be taken into consideration when designing bTBI studies, to better understand the role of stressors in the development of post-traumatic symptoms, and to establish a differential diagnosis for PTSD and bTBI.
C1 [Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Grunberg, Neil E.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
[Kamnaksh, Alaa; Kwon, Sook-Kyung; Ahmed, Farid; Grunberg, Neil E.; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA.
[Kovesdi, Erzsebet] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC USA.
[Long, Joseph] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurotrauma, Blast Induced Neurotrauma Branch, Silver Spring, MD USA.
RP Agoston, DV (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM vagoston@usuhs.edu
FU Center for Neuroscience and Regenerative Medicine (CNRM) [G1703F]
FX We thank the Neurotrauma Team (WRAIR) for their technical help during
the exposures. This work was supported by Center for Neuroscience and
Regenerative Medicine (CNRM) grant no. G1703F.
NR 46
TC 42
Z9 42
U1 0
U2 8
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT
PY 2011
VL 28
IS 10
BP 2145
EP 2153
DI 10.1089/neu.2011.1983
PG 9
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 839OX
UT WOS:000296378500015
PM 21861635
ER
PT J
AU Kuehn, R
Simard, PF
Driscoll, I
Keledjian, K
Ivanova, S
Tosun, C
Williams, A
Bochicchio, G
Gerzanich, V
Simard, JM
AF Kuehn, Reed
Simard, Philippe F.
Driscoll, Ian
Keledjian, Kaspar
Ivanova, Svetlana
Tosun, Cigdem
Williams, Alicia
Bochicchio, Grant
Gerzanich, Volodymyr
Simard, J. Marc
TI Rodent Model of Direct Cranial Blast Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE beta-amyloid precursor protein; caspase-3; primary blast injury;
traumatic brain injury
ID TRAUMATIC BRAIN-INJURY; AMYLOID PRECURSOR PROTEIN;
CENTRAL-NERVOUS-SYSTEM; CLOSED-HEAD INJURY; RAT-BRAIN;
INTRACRANIAL-PRESSURE; COGNITIVE FUNCTION; CIVILIAN INJURIES; EXPLOSIVE
BLAST; AXONAL INJURY
AB Traumatic brain injury resulting from an explosive blast is one of the most serious wounds suffered by war-fighters, yet the effects of explosive blast overpressure directly impacting the head are poorly understood. We developed a rodent model of direct cranial blast injury (dcBI), in which a blast overpressure could be delivered exclusively to the head, precluding indirect brain injury via thoracic transmission of the blast wave. We constructed and validated a Cranium Only Blast Injury Apparatus (COBIA) to deliver blast overpressures generated by detonating .22 caliber cartridges of smokeless powder. Blast waveforms generated by COBIA replicated those recorded within armored vehicles penetrated by munitions. Lethal dcBI (LD(50) similar to 515 kPa) was associated with: (1) apparent brainstem failure, characterized by immediate opisthotonus and apnea leading to cardiac arrest that could not be overcome by cardiopulmonary resuscitation; (2) widespread subarachnoid hemorrhages without cortical contusions or intracerebral or intraventricular hemorrhages; and (3) no pulmonary abnormalities. Sublethal dcBI was associated with: (1) apnea lasting up to 15 sec, with transient abnormalities in oxygen saturation; (2) very few delayed deaths; (3) subarachnoid hemorrhages, especially in the path of the blast wave; (4) abnormal immunolabeling for IgG, cleaved caspase-3, and beta-amyloid precursor protein (beta-APP), and staining for Fluoro-Jade C, all in deep brain regions away from the subarachnoid hemorrhages, but in the path of the blast wave; and (5) abnormalities on the accelerating Rotarod that persisted for the 1 week period of observation. We conclude that exposure of the head alone to severe explosive blast predisposes to significant neurological dysfunction.
C1 [Simard, Philippe F.; Keledjian, Kaspar; Ivanova, Svetlana; Tosun, Cigdem; Gerzanich, Volodymyr; Simard, J. Marc] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA.
[Bochicchio, Grant] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA.
[Simard, J. Marc] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.
[Simard, J. Marc] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA.
[Kuehn, Reed; Driscoll, Ian; Williams, Alicia] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Bochicchio, Grant] R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA.
RP Simard, JM (reprint author), Univ Maryland, Sch Med, Dept Neurosurg, 22 S Greene St,Suite S12D, Baltimore, MD 21201 USA.
EM msimard@smail.umaryland.edu
FU Department of the Army (U.S. Army Medical Research Acquisition Activity)
[PT074766, MD 21702-5014]
FX This work was supported by a grant to J.M.S. from the Department of the
Army (PT074766; the U.S. Army Medical Research Acquisition Activity, 820
Chandler Street, Fort Detrick, MD 21702-5014 is the awarding and
administering acquisition office). The information in this article does
not necessarily reflect the position or the policy of the United States
Government, and no official endorsement should be inferred.
NR 49
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U2 14
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT
PY 2011
VL 28
IS 10
BP 2155
EP 2169
DI 10.1089/neu.2010.1532
PG 15
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 839OX
UT WOS:000296378500016
PM 21639724
ER
PT J
AU Wang, Y
Wei, YL
Oguntayo, S
Wilkins, W
Arun, P
Valiyaveettil, M
Song, J
Long, JB
Nambiar, MP
AF Wang, Ying
Wei, Yanling
Oguntayo, Samuel
Wilkins, William
Arun, Peethambaran
Valiyaveettil, Manojkumar
Song, Jian
Long, Joseph B.
Nambiar, Madhusoodana P.
TI Tightly Coupled Repetitive Blast-Induced Traumatic Brain Injury:
Development and Characterization in Mice
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE blast exposure; neurobehavioral; neurobiological effects;
neuropathology; traumatic brain injury
ID ADULT-RAT BRAIN; CENTRAL-NERVOUS-SYSTEM; LASTING IMPULSE NOISE;
HEAD-INJURY; INTRACRANIAL-PRESSURE; OXIDATIVE STRESS; INDUCED
NEUROTRAUMA; COGNITIVE FUNCTION; EXPLOSIVE BLAST; AXONAL INJURY
AB A mouse model of repeated blast exposure was developed using a compressed air-driven shock tube, to study the increase in severity of traumatic brain injury (bTBI) after multiple blast exposures. Isoflurane anesthetized C57BL/6J mice were exposed to 13.9, 20.6, and 25 psi single blast overpressure (BOP1) and allowed to recover for 5 days. BOP1 at 20.6 psi showed a mortality rate of 2% and this pressure was used for three repeated blast exposures (BOP3) with 1 and 30 min intervals. Overall mortality rate in BOP3 was increased to 20%. After blast exposure, righting reflex time and body-weight loss were significantly higher in BOP3 animals compared to BOP1 animals. At 4 h, brain edema was significantly increased in BOP3 animals compared to sham controls. Reactive oxygen species in the cortex were increased significantly in BOP1 and BOP3 animals. Neuropathological analysis of the cerebellum and cerebral cortex showed dense silver precipitates in BOP3 animals, indicating the presence of diffuse axonal injury. Fluoro-Jade B staining showed increased intensity in the cortex of BOP3 animals indicating neurodegeneration. Rota Rod behavioral test showed a significant decrease in performance at 10 rpm following BOP1 or BOP3 at 2 h post-blast, which gradually recovered during the 5 days. At 20 rpm, the latency to fall was significantly decreased in both BOP1 and BOP3 animals and it did not recover in the majority of the animals through 5 days of testing. These data suggest that repeated blast exposures lead to increased impairment severity in multiple neurological parameters of TBI in mice.
C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Wilkins, William; Arun, Peethambaran; Valiyaveettil, Manojkumar; Song, Jian; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM Madhusoodana.nambiar@us.army.mil
RI Wilkins, William/B-5476-2011
NR 89
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U1 1
U2 12
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT
PY 2011
VL 28
IS 10
BP 2171
EP 2183
DI 10.1089/neu.2011.1990
PG 13
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 839OX
UT WOS:000296378500017
PM 21770761
ER
PT J
AU Shear, DA
Lu, XCM
Pedersen, R
Wei, G
Chen, ZY
Davis, A
Yao, CP
Dave, J
Tortella, FC
AF Shear, Deborah A.
Lu, Xi-Chun May
Pedersen, Rebecca
Wei, Guo
Chen, Zhiyong
Davis, Angela
Yao, Changping
Dave, Jitendra
Tortella, Frank C.
TI Severity Profile of Penetrating Ballistic-Like Brain Injury on
Neurofunctional Outcome, Blood-Brain Barrier Permeability, and Brain
Edema Formation
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE BBB; cognitive function; edema; PBBI; traumatic brain injury
ID CEREBRAL-ARTERY OCCLUSION; CAUDATE-PUTAMEN LESIONS; CEREBROSPINAL-FLUID;
HEAD-INJURY; WATER-MAZE; QUINOLINIC ACID; DORSAL STRIATUM; CELL-DEATH;
RAT; DEFICITS
AB This study evaluated the injury severity profile of unilateral, frontal penetrating ballistic-like brain injury (PBBI) on neurofunctional outcome, blood-brain barrier (BBB) permeability, and brain edema formation. The degree of injury severity was determined by the delivery of a water-pressure pulse designed to produce a temporary cavity by rapid (< 40 ms) expansion of the probe's elastic balloon calibrated to equal 5%, 10%, 12.5%, or 15% of total rat brain volume (control groups consisted of sham surgery or insertion of the probe only). Neurofunctional assessments revealed motor and cognitive deficits related to the degree of injury severity, with the most clear-cut profile of PBBI injury severity depicted by the Morris water maze (MWM) results. A biphasic pattern of BBB leakage was detected in the injured hemisphere at all injury severity levels at 4 h post-injury, and again at 48-72 h post-injury, which remained evident out to 7 days post-PBBI in the 10% and 12.5% PBBI groups. Likewise, significant brain edema was detected in the injured hemisphere by 4 h post-injury and remained elevated out to 7 days post-injury in the 10% and 12.5% PBBI groups. However, following 5% PBBI, significant levels of edema were only detected from 24 h to 48h post-injury. These results identify an injury severity profile of BBB permeability, brain edema, and neurofunctional impairment that provides sensitive and clinically relevant outcome metrics for studying potential therapeutics.
C1 [Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, MRMC UWI C, Silver Spring, MD 20910 USA.
RP Shear, DA (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, MRMC UWI C, Bldg 503-2W14, Silver Spring, MD 20910 USA.
EM Deborah.Shear@AMEDD.ARMY.MIL
RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011
NR 46
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U1 0
U2 5
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT
PY 2011
VL 28
IS 10
BP 2185
EP 2195
DI 10.1089/neu.2011.1916
PG 11
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 839OX
UT WOS:000296378500018
PM 21644814
ER
PT J
AU Wolfe, LL
Shenk, TM
Powell, B
Rocke, TE
AF Wolfe, Lisa L.
Shenk, Tanya M.
Powell, Bradford
Rocke, Tonie E.
TI ASSESSMENT OF A RECOMBINANT F1-V FUSION PROTEIN VACCINE INTENDED TO
PROTECT CANADA LYNX (LYNX CANADENSIS) FROM PLAGUE
SO JOURNAL OF WILDLIFE DISEASES
LA English
DT Article
DE Antibody; Canada lynx; Lynx canadensis; plague; titer; vaccine; Yersinia
pestis
ID FERRETS MUSTELA-NIGRIPES; PNEUMONIC PLAGUE; YERSINIA-PESTIS; MORTALITY;
COLORADO; ANTIGEN
AB As part of an ongoing restoration program in Colorado, USA, we evaluated adverse reactions and seroconversion in captive Canada lynx (Lynx canadensis) after vaccination with a recombinant F1-V fusion protein vaccine against Yersinia pestis, the bacterium that causes plague. Ten adult female lynx received the F1-V vaccine; 10 source- and age-matched lynx remained unvaccinated as controls. All of the vaccinated and control lynx remained apparently healthy throughout the confinement period. We observed no evidence of injection site or systemic reactions to the F1.-V vaccine. Among vaccinated lynx, differences in log(10) reciprocal antibody titers measured in sera collected before and after vaccination (two doses) ranged from 1.2 to 5.2 for anti-F1 antibodies and from 0.6 to 5.2 for anti-V antibodies; titers in unvaccinated lynx did not change appreciably over the course of confinement prior to release, and thus differences in anti-F1. (P=0.003) and anti-V (P=0.0005) titers were greater among vaccinated lynx than among controls. Although our findings suggest that the F1-V fusion protein vaccine evaluated here is likely to stimulate antibody responses that may help protect Canada lynx from plague, we observed no apparent differences in survival between vaccinated and unvaccinated subject animals. Retrospectively, 22 of 50 (44%; 95% confidence interval 29-59%) unvaccinated lynx captured or recaptured in Colorado during 2000-08 had passive hemagglutination antibody titers >1:16, consistent with exposure to Y. pestis; paired pre- and postrelease titers available for eight of these animals showed titer increases similar in magnitude to those seen in response to vaccination, suggesting at least some lynx may naturally acquire immunity to plague in Colorado habitats.
C1 [Wolfe, Lisa L.; Shenk, Tanya M.] Colorado Div Wildlife, Wildlife Res Ctr, Ft Collins, CO 80526 USA.
[Powell, Bradford] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
[Rocke, Tonie E.] US Geol Survey, Biol Resources Div, Natl Wildlife Hlth Lab, Madison, WI 53711 USA.
RP Wolfe, LL (reprint author), Colorado Div Wildlife, Wildlife Res Ctr, 317 W Prospect Rd, Ft Collins, CO 80526 USA.
EM lisa.wolfe@state.co.us
OI Rocke, Tonie/0000-0003-3933-1563
FU Colorado Division of Wildlife
FX This study was funded by the Colorado Division of Wildlife. We thank S.
and H. Deiterich for assistance with handling and care of captive lynx;
K. Griffin, L. Baeten and I. Levan for laboratory assistance; T. Spraker
for conducting the necropsies; L. Carter and J. Young for laboratory
analyses; P. Lukacs for analyzing serology data; and M. W. Miller and
anonymous reviewers for providing helpful comments on earlier drafts of
our manuscript.
NR 15
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U1 0
U2 3
PU WILDLIFE DISEASE ASSOC, INC
PI LAWRENCE
PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA
SN 0090-3558
J9 J WILDLIFE DIS
JI J. Wildl. Dis.
PD OCT
PY 2011
VL 47
IS 4
BP 888
EP 892
PG 5
WC Veterinary Sciences
SC Veterinary Sciences
GA 840AB
UT WOS:000296409500009
PM 22102659
ER
PT J
AU Bisson, IA
Butler, LK
Hayden, TJ
Kelley, P
Adelman, JS
Romero, LM
Wikelski, MC
AF Bisson, I. -A.
Butler, L. K.
Hayden, T. J.
Kelley, P.
Adelman, J. S.
Romero, L. M.
Wikelski, M. C.
TI Energetic response to human disturbance in an endangered songbird
SO ANIMAL CONSERVATION
LA English
DT Article
DE human disturbance; heart rate telemetry; energy expenditure; endangered
songbirds; fast life histories; vireo
ID HEART-RATE; ADRENOCORTICAL RESPONSES; STRESS-RESPONSE; EXPENDITURE;
PENGUINS; BEHAVIOR; BIRDS; REPRODUCTION; METABOLISM; TELEMETRY
AB Physiological changes in response to environmental stressors can reveal cryptic effects of disturbance that can potentially lead to species decline. However, such responses may vary with life history. We used heart rate telemetry to continuously and instantaneously measure energy expenditure in response to human-mediated disturbance in a free-living breeding population of the endangered [International Union for Conservation of Nature, vulnerable] black-capped vireo Vireo atricapilla (n = 10). Heart rate predicted 84% of energy expenditure as determined by respirometry (n = 3). Each bird mounted with a 0.5 g heart rate transmitter were subjected to standardized disturbance trials for 1 or 4 h during the day, and for 1 h at night. Only 1-h daytime disturbances elicited an increase in heart rate but this was not significant when compared with control no-disturbance periods. Our findings suggest that black-capped vireos quickly acclimate to a limited amount of human disturbance during the breeding season, which may be an adaptive response for any 'fast-living' species with a short life span and a short and synchronized breeding season. Because similar results were reported for another fast-living species, the common white-eyed vireo Vireo griseus, we suggest that life-history traits are stronger predictors of short-term physiological responses to disturbances than population status.
C1 [Bisson, I. -A.; Adelman, J. S.; Wikelski, M. C.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA.
[Butler, L. K.; Romero, L. M.] Tufts Univ, Dept Biol, Medford, MA 02155 USA.
[Hayden, T. J.] Engineer Res & Dev Ctr, Champaign, IL USA.
[Kelley, P.] Severn Elect, Annapolis, MD USA.
RP Bisson, IA (reprint author), Natl Zool Pk, Smithsonian Migratory Bird Ctr, POB 37102,MRC 5503, Washington, DC 20013 USA.
EM BissonI@si.edu
RI Kelley, Paul/C-9155-2016
FU Department of Defense through the US Army Corps of Engineers, Engineer
Research and Development Center [CS-1396, W9132T-05-C-0023]
FX We thank J.L. Granger, S. Lovell, A. Whitley, J. Ferrer, C. Pekins, D.
Cimprich, The Nature Conservancy (Fort Hood Chapter) and the Fort Hood
Natural Resources Management Branch for their assistance in the field.
We are also grateful for valuable comments on the paper from two
anonymous reviewers. This project was supported by the Department of
Defense, Strategic Environmental Research and Development Program,
Project CS-1396, through the US Army Corps of Engineers, Engineer
Research and Development Center, contract #W9132T-05-C-0023. Research
activities were conducted in accordance with all applicable Federal and
State of Texas wildlife and endangered species permits.
NR 44
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U1 2
U2 24
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1367-9430
J9 ANIM CONSERV
JI Anim. Conserv.
PD OCT
PY 2011
VL 14
IS 5
BP 484
EP 491
DI 10.1111/j.1469-1795.2011.00447.x
PG 8
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 846JX
UT WOS:000296894900006
ER
PT J
AU Shah, AR
Shah, SR
Oh, S
Ong, JL
Wenke, JC
Agrawal, CM
AF Shah, Amita R.
Shah, Sarita R.
Oh, Sunho
Ong, Joo L.
Wenke, Joseph C.
Agrawal, C. Mauli
TI Migration of Co-cultured Endothelial Cells and Osteoblasts in Composite
Hydroxyapatite/Polylactic Acid Scaffolds
SO ANNALS OF BIOMEDICAL ENGINEERING
LA English
DT Article
DE Endothelial cell migration; Osteoblast migration; Ceramic scaffold;
Polymer scaffold; Bone regeneration
ID TISSUE-ENGINEERED BONE; GROWTH-FACTOR; IN-VIVO; MODEL; VASCULARIZATION;
ANGIOGENESIS; PERMEABILITY; ARCHITECTURE; SUBSTITUTES; CROSSTALK
AB Regeneration of bone in large segmental bone defects requires regeneration of both cortical bone and trabecular bone. A scaffold design consisting of a hydroxyapatite (HA) ring surrounding a polylactic acid (PLA) core simulates the structure of bone and provides an environment for indirect and direct co-culture conditions. In this experiment, human umbilical vein endothelial cells (EC) and normal human primary osteoblasts (OB) were co-cultured to evaluate cell migration and interactions within this biphasic composite scaffold. Both cell types were able to migrate between the different material phases of the scaffold. It was also observed that OB migration increased when they were co-cultured with ECs, whereas EC migration decreased in co-culture. The results show that co-culture of ECs and OBs in this composite biphasic scaffold allows for migration of cells throughout the scaffold and that pre-seeding a scaffold with ECs can increase OB infiltration into desired areas of the scaffold.
C1 [Shah, Amita R.; Oh, Sunho; Ong, Joo L.; Agrawal, C. Mauli] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA.
[Shah, Amita R.; Shah, Sarita R.; Wenke, Joseph C.] USA, Inst Surg Res, San Antonio, TX USA.
[Shah, Amita R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Agrawal, CM (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA.
EM mauli.Agrawal@utsa.edu
FU NIH/RCMI [3G12RR013646-10S1]; Department of the Army [W81XWH-07-1-0717]
FX Special thanks to Dr. Colleen Witt and the UTSA CBI for instruction and
use of the confocal microscope and imaging software. This work was
partially supported by NIH/RCMI grant 3G12RR013646-10S1. Work for this
study was sponsored by the Department of the Army (Grant No.
W81XWH-07-1-0717). The US Army Medical Research Acquisition Activity,
820 Chandler Street, Fort Detrick, MD 21702-5014, USA, is the awarding
and administering acquisition office. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the Department of
the Army of the Department of Defense.
NR 33
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U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-6964
J9 ANN BIOMED ENG
JI Ann. Biomed. Eng.
PD OCT
PY 2011
VL 39
IS 10
BP 2501
EP 2509
DI 10.1007/s10439-011-0344-z
PG 9
WC Engineering, Biomedical
SC Engineering
GA 841JE
UT WOS:000296507800003
PM 21769541
ER
PT J
AU Cao, XY
Mastalerz, M
Chappell, MA
Miller, LF
Li, Y
Mao, JD
AF Cao, Xiaoyan
Mastalerz, Maria
Chappell, Mark A.
Miller, Lesley F.
Li, Yuan
Mao, Jingdong
TI Chemical structures of coal lithotypes before and after CO2 adsorption
as investigated by advanced solid-state C-13 nuclear magnetic resonance
spectroscopy
SO INTERNATIONAL JOURNAL OF COAL GEOLOGY
LA English
DT Article
DE Coal; Lithotype; CO2 adsorption; NMR
ID CARBON-DIOXIDE STORAGE; SOIL ORGANIC-MATTER; HUMIC ACIDS; NMR;
SELECTION; MACERALS; AROMATICITY; RANK; GAS
AB Four lithotypes (vitrain, bright clarain, clarain, and fusain) of a high volatile bituminous Springfield Coal from the Illinois Basin were characterized using advanced solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy. The NMR techniques included quantitative direct polarization/magic angle spinning (DP/MAS), cross polarization/total sideband suppression (CP/TOSS), dipolar dephasing, CHn selection, and recoupled C-H long-range dipolar dephasing techniques. The lithotypes that experienced high-pressure CO2 adsorption isotherm analysis were also analyzed to determine possible changes in coal structure as a result of CO2 saturation at high pressure and subsequent evacuation. The main carbon functionalities present in original vitrain, bright clarain, clarain and fusain were aromatic carbons (65.9%-86.1%), nonpolar alkyl groups (9.0%-28.9%), and aromatic C-O carbons (4.1%-9.5%). Among these lithotypes, aromaticity increased in the order of clarain, bright clarain, vitrain, and fusain, whereas the fraction of alkyl carbons decreased in the same order. Fusain was distinct from other three lithotypes in respect to its highest aromatic composition (86.1%) and remarkably small fraction of alkyl carbons (11.0%). The aromatic cluster size in fusain was larger than that in bright clarain. The lithotypes studied responded differently to high pressure CO2 saturation. After exposure to high pressure CO2, vitrain and fusain showed a decrease in aromaticity but an increase in the fraction of alkyl carbons, whereas bright clarain and clarain displayed an increase in aromaticity but a decrease in the fraction of alkyl carbons. Aromatic fused-rings were larger for bright clarain but smaller for fusain in the post-CO2 adsorption samples compared to the original lithotypes. These observations suggested chemical CO2-coal interactions at high pressure and the selectivity of lithotypes in response to CO2 adsorption. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
[Mastalerz, Maria] Indiana Univ, Indiana Geol Survey, Bloomington, IN 47405 USA.
[Chappell, Mark A.; Miller, Lesley F.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA.
EM jmao@odu.edu
RI Cao, Xiaoyan/E-3492-2012
OI Cao, Xiaoyan/0000-0001-7571-6482
FU National Science Foundation [EAR-0843996, CBET-0853950]
FX We would like to thank the National Science Foundation (EAR-0843996 and
CBET-0853950) for financial support.
NR 38
TC 8
Z9 10
U1 3
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-5162
J9 INT J COAL GEOL
JI Int. J. Coal Geol.
PD OCT 1
PY 2011
VL 88
IS 1
BP 67
EP 74
DI 10.1016/j.coal.2011.08.003
PG 8
WC Energy & Fuels; Geosciences, Multidisciplinary
SC Energy & Fuels; Geology
GA 841AT
UT WOS:000296485100006
ER
PT J
AU Gillrich, JJ
Allen, BP
Lichvar, RW
AF Gillrich, Jennifer J.
Allen, Bruce P.
Lichvar, Robert W.
TI The Effect of a Low-Cover Stratum-Woody Vines-on Vegetation
Determinations Made During Wetland Delineations
SO WETLANDS
LA English
DT Article
DE Dominance Ratio; Prevalence Index; Strata; Woody vines
ID WEIGHTED AVERAGES; DOMINANCE; FOREST
AB We examined the effect of a low-cover stratum-woody vines-on 1) the outcome of vegetation determinations made using the Prevalence Index (PI) and the Dominance Ratio (DR), and 2) agreement between vegetation and soils during wetland delineations in the United States. Different vine abundance measures-stem counts vs. percent cover-had no effect on the percentage of hydrophytic vegetation determinations made by either formula. Artificial increases and decreases to the woody vine stratum's minimum cover threshold of 5.0% also had no effect. However, in plots that contained borderline hydrophytic/nonhydrophytic vegetation, the percentage of hydrophytic vegetation determinations made by the DR decreased significantly when vine indicator status was artificially increased (p=0.048). The PI produced significantly fewer hydrophytic determinations in plots with nonhydric soils than in plots with hydric soils (p<0.001). The DR produced large percentages (81.8-100%) of hydrophytic determinations, regardless of soil type. Plots in which the DR and the PI differed had many commonalities, including nonhydric soils, nonhydrophytic PI/hydrophytic DR values, borderline hydrophytic vegetation, and an odd number of dominant species. During wetland delineations, the PI should be used in plant communities with low-cover strata, high species richness, or a high frequency of hydrophytes.
C1 [Gillrich, Jennifer J.; Lichvar, Robert W.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Gillrich, JJ (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
EM jennifer.j.gillrich@usace.army.mil
FU U.S. Army Corp of Engineers
FX This study was funded by the U.S. Army Corp of Engineers Wetland
Regulatory Assistance Program (WRAP). Site selection assistance was
provided by Aaron Damrill, Harold Keppler, David Knepper, Paul Minkin,
John Richey, Rich Ruby, and Mike Sheehan. John Richey also provided
valuable assistance with field sampling and plant identification. We
appreciate the thoughtful criticism of two anonymous reviewers.
NR 19
TC 0
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U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
J9 WETLANDS
JI Wetlands
PD OCT
PY 2011
VL 31
IS 5
BP 865
EP 873
DI 10.1007/s13157-011-0201-8
PG 9
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 843TJ
UT WOS:000296695200005
ER
PT J
AU Toren, KL
Bessinger, GT
Marquart, JD
AF Toren, Kristen L.
Bessinger, G. Todd
Marquart, Jason D.
TI Modification of the Running Suture to Avoid Wound Edge Protrusion
SO DERMATOLOGIC SURGERY
LA English
DT Editorial Material
C1 [Toren, Kristen L.; Marquart, Jason D.] Walter Reed Army Med Ctr, Dept Dermatol, Mohs Surg Procedural Dermatol Serv, Washington, DC 20307 USA.
[Bessinger, G. Todd] Bessinger Dermatol, Honolulu, HI USA.
RP Toren, KL (reprint author), 4720 Rosedale Ave 307, Bethesda, MD 20814 USA.
EM kltoren@gmail.com
NR 1
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1076-0512
EI 1524-4725
J9 DERMATOL SURG
JI Dermatol. Surg.
PD OCT
PY 2011
VL 37
IS 10
BP 1509
EP 1510
DI 10.1111/j.1524-4725.2011.02114.x
PG 2
WC Dermatology; Surgery
SC Dermatology; Surgery
GA 835HQ
UT WOS:000296027600018
PM 21790854
ER
PT J
AU Dong, JW
Zaghloul, AI
AF Dong, Junwei
Zaghloul, Amir I.
TI Hybrid Ray Tracing Method for Microwave Lens Simulation
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Fast simulation; microwave lens; ray tracing; Rotman lens
ID ROTMAN LENSES
AB Microwave lenses such as the Bootlace/Rotman lenses are designed by placing physical ports of lens input on the theoretical phase centers. These phase center positions are calculated using geometrical optic method under the assumptions of perfect cylindrical waves and true time delay. A real physical lens does not satisfy these conditions due to different port implementation approaches and mutual coupling effects. Full wave investigations and measurements have indicated strong variation at both phase and amplitude couplings between the input and output ports. Efficient theoretical models predicting both phase and amplitude performances are still in great demand to perform advanced lens optimization. The full wave simulation demonstrates accurate results. However, it is not convenient in optimization iterations due to its high computational cost and sophisticated programming process. Based on a ray tracing concept recently explored by the authors, this paper extends its design and formulate a suitable approach for general lens simulation. A microwave lens is systematically treated by hybrid of a flexible tapered port model and multiple-ray-path coupling approach. This method leads to designing the minimum return loss tapered port and fast lens simulation of reasonable accuracy. The predicted results of amplitude, phase couplings, array factors are validated by both full wave simulation and measurement. The comparison shows that the proposed method is fast, accurate and sufficient to predict various microwave lens parameters. This concept can be extended to designing stripline and waveguide lenses as well.
C1 [Dong, Junwei] Microwave Engn Corp MEC, N Andover, MA 01845 USA.
[Zaghloul, Amir I.] Virginia Tech, Bradley Dept Elect & Comp Engn, Falls Church, VA 22043 USA.
[Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20873 USA.
RP Dong, JW (reprint author), Microwave Engn Corp MEC, N Andover, MA 01845 USA.
EM JunweiD@gmail.com; amirz@vt.edu
NR 21
TC 0
Z9 0
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
EI 1558-2221
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD OCT
PY 2011
VL 59
IS 10
BP 3786
EP 3796
DI 10.1109/TAP.2011.2163762
PG 11
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 829KQ
UT WOS:000295579500033
ER
PT J
AU Walk, RM
Donahue, TF
Sharpe, RP
Safford, SD
AF Walk, Ryan M.
Donahue, Timothy F.
Sharpe, Richard P.
Safford, Shawn D.
TI Three phases of disaster relief in Haiti-pediatric surgical care on
board the United States Naval Ship Comfort
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Disasters; Earthquakes, Haiti; Disaster relief planning; Trauma;
Pediatrics; Surgical procedures, operative
ID EARTHQUAKE
AB Background: On January 12, 2010, Haiti experienced the western hemisphere's worst-ever natural disaster. Within 24 hours, the United States Naval Ship Comfort received orders to respond, and a group of more than 500 physicians, nurses, and staff undertook the largest and most rapid triage and treatment since the inception of hospital ships.
Methods: These data represent pediatric surgical patients treated aboard the United States Naval Ship Comfort between January 19 and February 27, 2010. Prospective databases managed by patient administration, radiology, blood bank, laboratory services, and surgical services were combined to create an overall patient care database that was retrospectively reviewed for this analysis.
Results: Two hundred thirty-seven pediatric surgical patients were treated, representing 27% of the total patient population. These patients underwent a total of 213 operations composed of 243 unique procedures. Orthopedic procedures represented 71% of the total caseload. Patients returned to the operating room up to 11 times and required up to 28 days for completion of surgical management.
Conclusions: This represents the largest cohort of pediatric surgical patients in an earthquake response. Our analysis provides a model for anticipating surgical caseload, injury patterns, and duration of surgical course in preparing for future disaster response missions. Moreover, we propose a 3-phased response to disaster medicine that has not been previously described. Published by Elsevier Inc.
C1 [Walk, Ryan M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Donahue, Timothy F.; Safford, Shawn D.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD 20889 USA.
[Sharpe, Richard P.] USN, Dept Surg, Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
RP Walk, RM (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
EM ryanmwalk@gmail.com
NR 9
TC 10
Z9 10
U1 0
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD OCT
PY 2011
VL 46
IS 10
BP 1978
EP 1984
DI 10.1016/j.jpedsurg.2011.04.014
PG 7
WC Pediatrics; Surgery
SC Pediatrics; Surgery
GA 839NG
UT WOS:000296373200027
PM 22008338
ER
PT J
AU Butler, FK
Blackbourne, LH
AF Butler, Frank K., Jr.
Blackbourne, Lorne H.
TI Reply to "(< C > ABC): How the British Military Deals With Trauma"
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Letter
ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; SPINE IMMOBILIZATION; FLUID
RESUSCITATION; SPECIAL OPERATIONS; WOUNDS; INJURY; DEATH
C1 [Butler, Frank K., Jr.] Def Hlth Board, Comm Tact Combat Casualty Care, Falls Church, VA USA.
[Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Butler, FK (reprint author), Def Hlth Board, Comm Tact Combat Casualty Care, Falls Church, VA USA.
NR 23
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD OCT
PY 2011
VL 71
IS 4
BP 1095
EP 1096
DI 10.1097/TA.0b013e31822f39a0
PG 2
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 833ZT
UT WOS:000295925700074
ER
PT J
AU Katsis, D
Burns, D
Henriquez, S
Howell, S
Litz, M
AF Katsis, Dimosthenis
Burns, David
Henriquez, Stanley
Howell, Steve
Litz, Marc
TI Development of a wireless radioactive material sensor network
SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS
SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
LA English
DT Article
DE Photomultiplier tube; Scintillaror; Geiger counter; Zigbee; Wireless
Network; Radiation detector; Special Nuclear Materials; Dirty Bomb
AB Our team at the United States Army Research Laboratory (ARL) has designed and developed a low-power, compact, wireless-networked gamma sensor (WGS) array. The WGS system provides high sensitivity gamma photon detection and remote warning for a broad range of radioactive materials. This sensor identifies the presence of a 1 mu Ci Cs137 source at a distance of 1.5 m. The networked array of sensors presently operates as a facility and laboratory sensor for the movement of radioactive check sources. Our goal has been to apply this architecture for field security applications by incorporating low-power design with compact packaging. The performance of this radiation measurement network is demonstrated for both detection and location of radioactive material. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Katsis, Dimosthenis; Burns, David; Henriquez, Stanley; Howell, Steve; Litz, Marc] USA, Res Lab, Athena Energy Corp, Bowie, MD USA.
RP Katsis, D (reprint author), USA, Res Lab, Athena Energy Corp, Bowie, MD USA.
EM katsisdc@ieee.org
NR 11
TC 3
Z9 3
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-9002
J9 NUCL INSTRUM METH A
JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc.
Equip.
PD OCT 1
PY 2011
VL 652
IS 1
BP 94
EP 98
DI 10.1016/j.nima.2010.08.121
PG 5
WC Instruments & Instrumentation; Nuclear Science & Technology; Physics,
Nuclear; Physics, Particles & Fields
SC Instruments & Instrumentation; Nuclear Science & Technology; Physics
GA 831XS
UT WOS:000295765000024
ER
PT J
AU Rudin, S
AF Rudin, Sergey
TI Viscous hydrodynamic model of non-linear plasma oscillations in
two-dimensional conduction channels and application to the detection of
terahertz signals
SO OPTICAL AND QUANTUM ELECTRONICS
LA English
DT Article; Proceedings Paper
CT 10th International Conference on Numerical Simulation of Optoelectronic
Devices (NUSOD)
CY SEP 06-09, 2010
CL Atlanta, GA
DE Gated conduction channel; Plasma resonance; Terahertz response
ID ACOUSTIC-PHONON SCATTERING; FIELD-EFFECT TRANSISTOR; HETEROSTRUCTURES;
RADIATION; FLUID
AB In the Dyakonov-Shur detector the plasma resonance in a short channel High Electron Mobility Transistor is used for the resonant tunable detection of terahertz radiation. We derived a viscous hydrodynamic model with temperature dependent transport coefficients for the gated conduction channel. We evaluated the detector response function and obtained the quality factor of the plasma resonance.
C1 USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
RP Rudin, S (reprint author), USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
EM sergey.i.rudin.civ@mail.mil
NR 16
TC 3
Z9 3
U1 1
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0306-8919
J9 OPT QUANT ELECTRON
JI Opt. Quantum Electron.
PD OCT
PY 2011
VL 42
IS 11-13
SI SI
BP 793
EP 799
DI 10.1007/s11082-011-9484-5
PG 7
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA 839OK
UT WOS:000296377000019
ER
PT J
AU Grujicic, M
Bell, WC
Pandurangan, B
Cheeseman, BA
Fountzoulas, C
Patel, P
Templeton, DW
Bishnoi, KD
AF Grujicic, M.
Bell, W. C.
Pandurangan, B.
Cheeseman, B. A.
Fountzoulas, C.
Patel, P.
Templeton, D. W.
Bishnoi, K. D.
TI The effect of high-pressure densification on ballistic-penetration
resistance of a soda-lime glass
SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF
MATERIALS-DESIGN AND APPLICATIONS
LA English
DT Article
DE glass; molecular-level modelling and simulations; high-pressure
irreversible densification
ID BRITTLE MATERIALS; MOLECULAR-DYNAMICS; MATERIAL MODEL; FORCE-FIELD;
FRAGMENTATION; COMPASS; SILICA; DAMAGE; ARMOR
AB Molecular-level modelling and simulations of the high-pressure volumetric response and irreversible densification of a prototypical soda-lime glass are first employed. The molecular-simulation results obtained were next used to modify the pressure versus degree-of-compression (the negative of volumetric strain) and yield strength versus pressure relations in order to account for the effects of irreversible densification. These relations are next used to upgrade the equation of state and the strength constitutive laws of an existing material model for glass. This was followed by a set of transient non-linear dynamics calculations of the transverse impact of a glass test plate with a solid right-circular cylindrical steel projectile. The results obtained show that irreversible densification can provide only a minor improvement in the ballistic resistance of glass and only in the case of high-velocity (ca. 1000 m/s) projectiles. Furthermore, it was demonstrated that if the key irreversible compaction parameters can be adjusted by modifications in glass chemistry and microstructure, significant improvements in the glass ballistic resistance can be attained over a relatively wide range of projectile velocities.
C1 [Grujicic, M.; Bell, W. C.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Cheeseman, B. A.; Fountzoulas, C.; Patel, P.] USA, Res Lab, Survivabil Mat Branch, Aberdeen, MD USA.
[Templeton, D. W.; Bishnoi, K. D.] USA, TARDEC, Warren, MI USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM mica.grujicic@ces.clemson.edu
FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042];
ARC-TARDEC
FX The material presented in this study is based on work supported by the
U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and
W911NF-06-2-0042 and by an ARC-TARDEC research contract.
NR 31
TC 11
Z9 11
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1464-4207
EI 2041-3076
J9 P I MECH ENG L-J MAT
JI Proc. Inst. Mech. Eng. Pt. L-J. Mater.-Design Appl.
PD OCT
PY 2011
VL 225
IS L4
BP 298
EP 315
DI 10.1177/1464420711412849
PG 18
WC Materials Science, Multidisciplinary
SC Materials Science
GA 833ML
UT WOS:000295889500008
ER
PT J
AU Batchinsky, AI
Burkett, SE
Zanders, TB
Chung, KK
Regn, DD
Jordan, BS
Necsoiu, C
Nguyen, R
Hanson, MA
Morris, MJ
Cancio, LC
AF Batchinsky, Andriy I.
Burkett, Samuel E.
Zanders, Thomas B.
Chung, Kevin K.
Regn, Dara D.
Jordan, Bryan S.
Necsoiu, Corina
Nguyen, Ruth
Hanson, Margaret A.
Morris, Michael J.
Cancio, Leopoldo C.
TI Comparison of airway pressure release ventilation to conventional
mechanical ventilation in the early management of smoke inhalation
injury in swine
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE acute respiratory distress syndrome; mechanical ventilation; smoke
inhalation injury; swine
ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; FREQUENCY OSCILLATORY
VENTILATION; TIDAL-VOLUME VENTILATION; PERFUSION DISTRIBUTIONS;
PERCUSSIVE VENTILATION; SHEEP MODEL; TRIAL; MORTALITY; STRATEGY
AB Objective: The role of airway pressure release ventilation in the management of early smoke inhalation injury has not been studied. We compared the effects of airway pressure release ventilation and conventional mechanical ventilation on oxygenation in a porcine model of acute respiratory distress syndrome induced by wood smoke inhalation.
Design: Prospective animal study.
Setting: Government laboratory animal intensive care unit.
Patients: Thirty-three Yorkshire pigs.
Interventions: Smoke inhalation injury.
Measurements and Main Results: Anesthetized female Yorkshire pigs (n = 33) inhaled room-temperature pine-bark smoke. Before injury, the pigs were randomized to receive conventional mechanical ventilation (n = 15) or airway pressure release ventilation (n = 12) for 48 hrs after smoke inhalation. As acute respiratory distress syndrome developed (PaO(2)/FIO(2) ratio <200), plateau pressures were limited to <35 cm H(2)O. Six uninjured pigs received conventional mechanical ventilation for 48 hrs and served as time controls. Changes in PaO(2)/FIO(2) ratio, tidal volume, respiratory rate, mean airway pressure, plateau pressure, and hemodynamic variables were recorded. Survival was assessed using Kaplan-Meier analysis. PaO(2)/FIO(2) ratio was lower in airway pressure release ventilation vs. conventional mechanical ventilation pigs at 12, 18, and 24 hrs (p < .05) but not at 48 hrs. Tidal volumes were lower in conventional mechanical ventilation animals between 30 and 48 hrs post injury (p < .05). Respiratory rates were lower in airway pressure release ventilation at 24, 42, and 48 hrs (p < .05). Mean airway pressures were higher in airway pressure release ventilation animals between 6 and 48 hrs (p < .05). There was no difference in plateau pressures, hemodynamic variables, or survival between conventional mechanical ventilation and airway pressure release ventilation pigs.
Conclusions: In this model of acute respiratory distress syndrome caused by severe smoke inhalation in swine, airway pressure release ventilation-treated animals developed acute respiratory distress syndrome faster than conventional mechanical ventilation-treated animals, showing a lower PaO(2)/FIO(2) ratio at 12, 18, and 24 hrs after injury. At other time points, PaO(2)/FIO(2) ratio was not different between conventional mechanical ventilation and airway pressure release ventilation. (Crit Care Med 2011; 39:2314-2321)
C1 [Batchinsky, Andriy I.; Chung, Kevin K.; Jordan, Bryan S.; Necsoiu, Corina; Nguyen, Ruth; Hanson, Margaret A.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Burkett, Samuel E.; Zanders, Thomas B.; Regn, Dara D.; Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Sam Houston, TX 78234 USA.
RP Batchinsky, AI (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM andriy.batchinsky@amedd.army.mil
RI Necsoiu, Corina/A-6255-2013
FU Combat Critical Care Engineering Task Area; Combat Casualty Care
Research Area Directorate, U.S. Army Medical Research, and Materiel
Command
FX Supported, in part, by the Combat Critical Care Engineering Task Area,
Combat Casualty Care Research Area Directorate, U.S. Army Medical
Research, and Materiel Command.
NR 42
TC 16
Z9 16
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
J9 CRIT CARE MED
JI Crit. Care Med.
PD OCT
PY 2011
VL 39
IS 10
BP 2314
EP 2321
DI 10.1097/CCM.0b013e318225b5b3
PG 8
WC Critical Care Medicine
SC General & Internal Medicine
GA 821EU
UT WOS:000294958500016
PM 21705889
ER
PT J
AU Reed, BG
Lowery, WJ
Keyser, EA
Kost, ER
Sundborg, MJ
Winter, WE
Landt, C
Leath, CA
AF Reed, Beverly G.
Lowery, William J.
Keyser, Erin A.
Kost, Edward R.
Sundborg, Michael J.
Winter, William E., III
Landt, Cristy
Leath, Charles A., III
TI Surgically managed stage I endometrial cancer in a low-volume center:
outcomes and complications in a military residency program
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE endometrial cancer; laparoscopy; laparotomy
ID OVARIAN-CANCER; LAPAROSCOPY; LAPAROTOMY; SURVIVAL; ONCOLOGY; TRIAL;
COST; CARE
AB OBJECTIVE: The purpose of this study was to compare operative outcomes and complications for patients with endometrial cancer who underwent staging by laparoscopy vs laparotomy in a low-volume facility.
STUDY DESIGN: Research was conducted with a retrospective cohort of surgical patients with clinical stage I endometrial cancer from 2004-2009.
RESULTS: Eighty-six demographically similar patients (50 laparotomy and 36 laparoscopy) were identified. Laparoscopy had less estimated blood loss (339 vs 558 mL; P = .013) and lower rates of transfusion (5.6% vs 24%; P = .02). Laparoscopy was longer (281 vs 202 minutes; P < .0005) but required a shorter hospital stay (2.2 vs 5.5 days; P < .0005). Laparoscopy patients had fewer overall complications (16.7% vs 32%; P = .11). No differences in final surgical stage or lymph node yields between the groups were present.
CONCLUSION: Although a longer procedure, laparoscopy had fewer complications and shorter hospital stays. Prolonged operative time, compared with published experience, is potentially the result of unique factors in our center.
C1 [Reed, Beverly G.; Lowery, William J.; Keyser, Erin A.; Kost, Edward R.; Leath, Charles A., III] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA.
[Landt, Cristy] Brooke Army Med Ctr, Dept Clin Investigat, Ft Sam Houston, TX 78234 USA.
[Sundborg, Michael J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA.
[Winter, William E., III] NW Canc Specialists, Portland, OR USA.
RP Leath, CA (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
OI Leath III, Charles/0000-0002-4034-6845
NR 23
TC 1
Z9 1
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD OCT
PY 2011
VL 205
IS 4
AR 356.e1
DI 10.1016/j.ajog.2011.05.007
PG 5
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 836CB
UT WOS:000296084600035
PM 21689805
ER
PT J
AU Eastridge, BJ
Salinas, J
Wade, CE
Blackbourne, LH
AF Eastridge, Brian J.
Salinas, Jose
Wade, Charles E.
Blackbourne, Lorne H.
TI Hypotension is 100 mm Hg on the battlefield
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Hypotension; Shock; Trauma; Combat; Base deficit; Systolic blood
pressure; Mortality
ID TRAUMA PATIENTS; BLOOD-PRESSURE; INJURY SEVERITY; BASE DEFICIT; VITAL
SIGNS; DEATH; TRANSFUSION; PREDICTORS; HEMORRHAGE; ACCURATE
AB BACKGROUND: Historically, emergency physicians and trauma surgeons have referred to a systolic blood pressure (SBP) of 90 mm Hg as hypotension. Recent evidence from the civilian trauma literature suggests that 110 mm Hg may be more appropriate based on associated acidosis and outcome measures. In this analysis, we sought to determine the relationship between SBP, hypoperfusion, and mortality in the combat casualty.
METHODS: A total of 7,180 US military combat casualties from the Joint Theater Trauma Registry from 2002 to 2009 were analyzed with respect to admission SBP, base deficit, and mortality. Base deficit, as a measure of hypoperfusion, and mortality were plotted against 10-mm Hg increments in admission SBP.
RESULTS: By plotting SBP, baseline mortality was less than 2% down to a level of 101 to 110 mm Hg, at which point the slope of the curve increased dramatically to a mortality rate of 45.1% in casualties with an SBP of 60 mm Hg or less but more than 0 mm Hg. A presenting SBP of 0 mm Hg was associated with 100% mortality. The data also established a similar effect for base deficit with a sharp increase in the rate of acidosis, which became manifest at an SBP in the range of 90 to 100 mm Hg.
CONCLUSIONS: This analysis shows that an SBP of 100 mm Hg or less may be a better and more clinically relevant definition of hypotension and impending hypoperfusion in the combat casualty. One utility of this analysis may be the more expeditious identification of battlefield casualties in need of life-saving interventions such as the need for blood or surgical intervention. Published by Elsevier Inc.
C1 [Eastridge, Brian J.; Salinas, Jose; Wade, Charles E.; Blackbourne, Lorne H.] USA, Inst Surg Res, MCMR SRJ, Ft Sam Houston, TX 78234 USA.
RP Eastridge, BJ (reprint author), USA, Inst Surg Res, MCMR SRJ, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM brian.eastridge@amedd.army.mil
NR 21
TC 16
Z9 16
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD OCT
PY 2011
VL 202
IS 4
BP 404
EP 408
DI 10.1016/j.amjsurg.2010.10.012
PG 5
WC Surgery
SC Surgery
GA 834PU
UT WOS:000295975800009
PM 21943946
ER
PT J
AU Sirichaisinthop, J
Buates, S
Watanabe, R
Han, ET
Suktawonjaroenpon, W
Krasaesub, S
Takeo, S
Tsuboi, T
Sattabongkot, J
AF Sirichaisinthop, Jeeraphat
Buates, Sureemas
Watanabe, Risa
Han, Eun-Taek
Suktawonjaroenpon, Wachira
Krasaesub, Somporn
Takeo, Satoru
Tsuboi, Takafumi
Sattabongkot, Jetsumon
TI Short Report: Evaluation of Loop-Mediated Isothermal Amplification
(LAMP) for Malaria Diagnosis in a Field Setting
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; PLASMODIUM-FALCIPARUM; THAILAND; INFECTIONS;
PARASITES; AREA; PCR
AB We used the loop-mediated isothermal amplification (LAMP) method developed by our group for malaria diagnosis with genus-specific and species-specific primers for the four human malaria parasites at a field clinic in comparison with standard microscopy. Among 110 blood samples collected from the malaria clinic in Thailand, LAMP detected 59 of 60 samples positive by microscopy (sensitivity = 98.3%) and none of the 50 microscopy-negative samples (specificity = 100%). Negative predictive value (NPV) and positive predictive value (PPV) of LAMP were 98% and 100%, respectively. These results indicate that LAMP is an effective tool for malaria diagnosis at a field clinic in a field setting.
C1 [Buates, Sureemas] Mahidol Univ, Dept Microbiol, Fac Sci, Bangkok 10400, Thailand.
[Sirichaisinthop, Jeeraphat] Vector Borne Dis Training Ctr, Pra Budhabat 18120, Saraburi, Thailand.
[Watanabe, Risa; Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan.
[Han, Eun-Taek] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, South Korea.
[Suktawonjaroenpon, Wachira] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan.
[Sattabongkot, Jetsumon] Mahidol Univ, Mahidol Vivax Res Ctr, Fac Trop Med, Bangkok 10400, Thailand.
RP Buates, S (reprint author), Mahidol Univ, Dept Microbiol, Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand.
EM grphat@yahoo.com; sbuates@hotmail.com; risa@m.ehime-u.ac.jp;
etaekhan@yahoo.com; wachiras@afrims.org; pornk@afrims.org;
satoru@m.ehime-u.ac.jp; tsuboi@ccr.ehime-u.ac.jp;
tmjetsumon@mahidol.ac.th
FU World Health Organization/Southeast Asia Regional Office [OSER2 P2 A4,
6149175]
FX This study was supported by the World Health Organization/Southeast Asia
Regional Office (OSER2 P2 A4, AMS Code: 6149175).
NR 15
TC 26
Z9 27
U1 1
U2 9
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD OCT
PY 2011
VL 85
IS 4
BP 594
EP 596
DI 10.4269/ajtmh.2011.10-0676
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 833QB
UT WOS:000295898900004
PM 21976556
ER
PT J
AU Cusatis, G
Mencarelli, A
Pelessone, D
Baylot, J
AF Cusatis, Gianluca
Mencarelli, Andrea
Pelessone, Daniele
Baylot, James
TI Lattice Discrete Particle Model (LDPM) for failure behavior of concrete.
II: Calibration and validation
SO CEMENT & CONCRETE COMPOSITES
LA English
DT Article
DE Concrete; Fracture; Failure; Discrete models; Lattice models; Particle
models; Calibration; Validation
ID BOUNDARY-CONDITIONS; MICROPLANE MODEL; BRAZILIAN TEST; COMPRESSION;
VERIFICATION; TESTS; RATIO
AB The Lattice Discrete Particle Model (LDPM) formulated in the preceding Part I of this study is calibrated and validated in the present Part II. Calibration and validation is performed by comparing the results of numerical simulations with experimental data gathered from the literature. Simulated experiments include uniaxial and multiaxial compression, tensile fracture, shear strength, and cycling compression tests. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Cusatis, Gianluca] Rensselaer Polytech Inst, Dept Civil & Environm Engn, Johnsson Engn Ctr 4048, Troy, NY 12180 USA.
[Pelessone, Daniele] Engn & Software Syst Solut Inc E53, San Diego, CA 92101 USA.
[Baylot, James] USA, Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
RP Cusatis, G (reprint author), Rensselaer Polytech Inst, Dept Civil & Environm Engn, Johnsson Engn Ctr 4048, 110 8th St, Troy, NY 12180 USA.
EM cusatg@rpi.edu; mencaa@rpi.edu; peless@es3inc.com;
James.T.Baylot@usace.army.mil
RI Cusatis, Gianluca/G-2539-2011;
OI Cusatis, Gianluca/0000-0001-7436-3910
FU US Army Engineer Research and Development Center; NSF [0928448]; DTRA
[HDTRA1-09-1-0029]
FX This effort was sponsored by the US Army Engineer Research and
Development Center. Permission to publish was granted by the Director,
Geotechnical and Structures Laboratory. The work of first author was
also supported under NSF Grant No. 0928448 and DTRA Grant No.
HDTRA1-09-1-0029 to Rensselaer Polytechnic Institute.
NR 32
TC 49
Z9 51
U1 2
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0958-9465
J9 CEMENT CONCRETE COMP
JI Cem. Concr. Compos.
PD OCT
PY 2011
VL 33
IS 9
BP 891
EP 905
DI 10.1016/j.cemconcomp.2011.02.010
PG 15
WC Construction & Building Technology; Materials Science, Composites
SC Construction & Building Technology; Materials Science
GA 837EE
UT WOS:000296173100004
ER
PT J
AU Mustafa, ML
Ayazi, E
Mohareb, E
Yingst, S
Zayed, A
Rossi, CA
Schoepp, RJ
Mofleh, J
Fiekert, K
Akhbarian, Z
Sadat, H
Leslie, T
AF Mustafa, Mir Lais
Ayazi, Edris
Mohareb, Emad
Yingst, Sam
Zayed, Alia
Rossi, Cynthia A.
Schoepp, Randal J.
Mofleh, Jawad
Fiekert, Kathy
Akhbarian, Zarif
Sadat, Homayoon
Leslie, Toby
TI Crimean-Congo Hemorrhagic Fever, Afghanistan, 2009
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
AB In response to an outbreak of Crimean-Congo hemorrhagic fever in western Afghanistan, we measured immunoglobulin G seroprevalence among household members and their animals. Seroprevalence was 11.2% and 75.0% in humans (n = 330) and livestock (n = 132), respectively. Persons with frequent exposure to cattle had an elevated risk of being immunoglobulin G positive.
C1 [Mustafa, Mir Lais] Minist Publ Hlth, Afghan Publ Hlth Inst, Res Dept, Kabul, Afghanistan.
[Mohareb, Emad; Zayed, Alia] USN, Med Res Unit 3, Cairo, Egypt.
[Yingst, Sam; Rossi, Cynthia A.; Schoepp, Randal J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Fiekert, Kathy; Leslie, Toby] Hlth Protect & Res Org, Kabul, Afghanistan.
[Leslie, Toby] London Sch Hyg & Trop Med, London WC1, England.
RP Mustafa, ML (reprint author), Minist Publ Hlth, Afghan Publ Hlth Inst, Res Dept, Kabul, Afghanistan.
EM laismustafa@yahoo.com
RI Valle, Ruben/A-7512-2013
FU World Health Organization/World Bank from the Eastern Mediterranean
Regional Office [2007/56]; Division of Global Emerging Infections
Surveillance Operations at the Armed Forces Health Surveillance Center
through the US Army Medical Research Institute for Infectious Diseases
[C0169_10_RD]; NAMRU-3
FX The field work for this study was funded by World Health
Organization/World Bank Special Programme for Research and Training in
Tropical Diseases from the Eastern Mediterranean Regional Office, grant
no. 2007/56. Laboratory work was funded by the Division of Global
Emerging Infections Surveillance Operations at the Armed Forces Health
Surveillance Center, Research Plan C0169_10_RD, through the US Army
Medical Research Institute for Infectious Diseases and NAMRU-3.
NR 5
TC 17
Z9 19
U1 0
U2 4
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD OCT
PY 2011
VL 17
IS 10
BP 1940
EP 1941
DI 10.3201/eid1710.110061
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 833PL
UT WOS:000295897300031
PM 22000377
ER
PT J
AU Rickards, CA
Ryan, KL
Cooke, WH
Convertino, VA
AF Rickards, Caroline A.
Ryan, Kathy L.
Cooke, William H.
Convertino, Victor A.
TI Tolerance to central hypovolemia: the influence of oscillations in
arterial pressure and cerebral blood velocity
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE lower body negative pressure; hemorrhage; hypovolemia; high tolerance;
low tolerance
ID BODY NEGATIVE-PRESSURE; SYMPATHETIC-NERVE ACTIVITY; ORTHOSTATIC
TACHYCARDIA SYNDROME; SQUAT-STAND MANEUVERS; TILT-INDUCED SYNCOPE;
HEAD-UP TILT; FLOW-VELOCITY; BAROREFLEX SENSITIVITY; INSPIRATORY
RESISTANCE; UPRIGHT TILT
AB Rickards CA, Ryan KL, Cooke WH, Convertino VA. Tolerance to central hypovolemia: the influence of oscillations in arterial pressure and cerebral blood velocity. J Appl Physiol 111: 1048-1058, 2011. First published July 28, 2011; doi:10.1152/japplphysiol.00231.2011.- Higher oscillations of cerebral blood velocity and arterial pressure (AP) induced by breathing with inspiratory resistance are associated with delayed onset of symptoms and increased tolerance to central hypovolemia. We tested the hypothesis that subjects with high tolerance (HT) to central hypovolemia would display higher endogenous oscillations of cerebral blood velocity and AP at presyncope compared with subjects with low tolerance (LT). One-hundred thirty-five subjects were exposed to progressive lower body negative pressure (LBNP) until the presence of presyncopal symptoms. Subjects were classified as HT if they completed at least the -60-mmHg level of LBNP (93 subjects; LBNP time, 1,880 +/- 259 s) and LT if they did not complete this level (42 subjects; LBNP time, 1,277 +/- 199 s). Middle cerebral artery velocity (MCAv) was measured by transcranial Doppler, and AP was measured at the finger by photoplethysmography. Mean MCAv and mean arterial pressure (MAP) decreased progressively from baseline to presyncope for both LT and HT subjects (P < 0.001). However, low frequency (0.04-0.15 Hz) oscillations of mean MCAv and MAP were higher at presyncope in HT subjects compared with LT subjects (MCAv: HT, 7.2 +/- 0.7 vs. LT, 5.3 +/- 0.6 (cm/s)(2), P = 0.075; MAP: HT, 15.3 +/- 1.4 vs. 7.9 +/- 1.2 mmHg(2), P < 0.001). Consistent with our previous findings using inspiratory resistance, high oscillations of mean MCAv and MAP are associated with HT to central hypovolemia.
C1 [Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA.
[Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Rickards, CA (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA.
EM caroline.rickards@us.army.mil
FU US Army
FX This research was supported by funding from the US Army Combat Casualty
Care Program. The views expressed herein are the private views of the
authors and are not to be construed as representing those of the US
Department of the Army or the US Department of Defense.
NR 73
TC 36
Z9 36
U1 1
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD OCT
PY 2011
VL 111
IS 4
BP 1048
EP 1058
DI 10.1152/japplphysiol.00231.2011
PG 11
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 834OR
UT WOS:000295972000014
PM 21799129
ER
PT J
AU Hogan, DW
AF Hogan, David W., Jr.
TI Head and Heart: The Dilemmas of American Attitudes Toward War
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
ID WORLD-WAR; CIVIL-WAR; MEMORY; NATIONALISM; HISTORY; CLASH; ARMY
AB In recent years, Afghanistan and Iraq have drawn new attention to an old subject: American attitudes toward warfare. This essay surveys the existing literature to approach this problem through the interlocking factors of reason and feeling. At first, Americans reconciled these factors, and justified their wars, because republicanism, romantic nationalism, and Victorian culture created the comforting sense of a chosen nation in an orderly, moral cosmos. When two world wars and the Great Depression produced modernist doubt, Americans used nationalism, pragmatism, and faith in technology to guide and sustain them. By the late twentieth century, however, modernist challenges to old universals in a larger and more pluralistic society became harder to reconcile as debates over wars polarized along emotional extremes, while reason's proponents clung to a precarious middle ground. Currently, the prospect of a revived consensus appears remote.
C1 USA, Ctr Mil Hist, Gen Hist Branch, Washington, DC 20310 USA.
RP Hogan, DW (reprint author), USA, Ctr Mil Hist, Gen Hist Branch, Washington, DC 20310 USA.
NR 274
TC 2
Z9 2
U1 2
U2 6
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1021
EP 1054
PG 34
WC History
SC History
GA 831SZ
UT WOS:000295752700001
ER
PT J
AU Donnelly, WM
AF Donnelly, William M.
TI Bilko's Army: A Crisis in Command?
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB A major criticism of the U.S. Army during the Vietnam War is that it suffered from a crisis in command, especially among officers above the company grade level. Most writing on this topic has centered on structural issues, such as post World War II personnel policies. This article will examine this phenomenon between the Korean and Vietnam wars by comparing contemporary publications and retrospective critiques by veterans with internal Army sources, particularly service schools, the headquarters of the Continental Army Command, and Headquarters, Department of the Army. If a crisis in command existed between 1953 and 1965, did these organizations' leaders recognize it and address it?
C1 USA, Ctr Mil Hist, Washington, DC 20310 USA.
RP Donnelly, WM (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA.
NR 163
TC 2
Z9 2
U1 2
U2 2
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1183
EP 1215
PG 33
WC History
SC History
GA 831SZ
UT WOS:000295752700006
ER
PT J
AU Matheny, MR
AF Matheny, Michael R.
TI The Evolution of Operational Art from Napoleon to the Present.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Matheny, Michael R.] USA, War Coll, Carlisle, PA USA.
RP Matheny, MR (reprint author), USA, War Coll, Carlisle, PA USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1294
EP 1295
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700023
ER
PT J
AU House, JM
AF House, Jonathan M.
TI Why Stalin's Soldiers Fought: The Red Army's Military Effectiveness in
World War II.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1342
EP 1343
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700056
ER
PT J
AU Bruscino, T
AF Bruscino, Thomas
TI The United States and the Second World War: New Perspectives on
Diplomacy, War, and the Home Front.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Bruscino, Thomas] USA, Sch Adv Mil Study, Ft Leavenworth, KS USA.
RP Bruscino, T (reprint author), USA, Sch Adv Mil Study, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1343
EP 1344
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700057
ER
PT J
AU Carter, BL
AF Carter, Bradley L.
TI The "Good War" in American Memory.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Carter, Bradley L.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
RP Carter, BL (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1351
EP 1352
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700062
ER
PT J
AU Bourque, SA
AF Bourque, Stephen A.
TI The Rucksack War: US Army Operational Logistics in Grenada, 1983.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Bourque, Stephen A.] USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA.
RP Bourque, SA (reprint author), USA, Sch Adv Mil Studies, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1357
EP 1358
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700066
ER
PT J
AU Grau, LW
AF Grau, Lester W.
TI The Insurgency in Chechnya and the North Caucasus: From Gazavat to
Jihad.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Grau, Lester W.] Foreign Mil Studies Off, Ft Leavenworth, KS USA.
RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2011
VL 75
IS 4
BP 1358
EP 1359
PG 2
WC History
SC History
GA 831SZ
UT WOS:000295752700067
ER
PT J
AU Olson, SW
Arbogast, CB
Baker, TP
Owshalimpur, D
Oliver, DK
Abbott, KC
Yuan, CM
AF Olson, Stephen W.
Arbogast, Charles B.
Baker, Thomas P.
Owshalimpur, David
Oliver, David K.
Abbott, Kevin C.
Yuan, Christina M.
TI Asymptomatic Autoantibodies Associate with Future Anti-glomerular
Basement Membrane Disease
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID ANTI-GBM ANTIBODIES; NORMAL HUMAN SERA; GOODPASTURE AUTOANTIGEN;
T-CELLS; CRESCENTIC GLOMERULONEPHRITIS; WEGENERS GRANULOMATOSIS; IV
COLLAGEN; NEPHRITIS; ANCA; ALPHA-3(IV)NC1
AB The pathophysiology of anti-glomerular basement membrane (anti-GBM) disease before clinical presentation is unknown. The presence of anti-GBM, anti-proteinase 3 (PR3), and anti-myeloperoxidase (MPO) antibodies associate with the disease at the time of diagnosis, but little is known about the presence of these autoantibodies before diagnosis. We used serum samples from the Department of Defense Serum Repository to conduct a case-control study involving 30 patients diagnosed with anti-GBM disease and 30 healthy controls matched for the age, gender, race, and age of the serum samples. We analyzed a maximum of three samples from each subject: the most recent sample before diagnosis, the penultimate sample before diagnosis, and the oldest sample available; the average time between the most recent sample and diagnosis was 195 days (range, 4 to 1346 days). Elevated anti-GBM levels (>= 3 U/ml) were present in four patients, all less than 1 year before diagnosis but in no controls. Detectable anti-GBM antibody levels (>= 1 U/ml but <3 U/ml) in a single serum sample before diagnosis were more frequent in cases than controls (70% versus 17%, P < 0.001). Only study patients had detectable anti-GBM levels in multiple samples before diagnosis (50% versus 0%, P < 0.001). Almost all patients had detectable anti-PR3 and/or anti-MPO that preceded the onset of disease. Among patients with a clear antecedent antibody, anti-PR3 or anti-MPO always became detectable before the anti-GBM antibody. In summary, our data describe the subclinical formation of autoantibodies, which improves our understanding of the pathophysiology of anti-GBM disease.
C1 [Olson, Stephen W.; Oliver, David K.; Abbott, Kevin C.; Yuan, Christina M.] Walter Reed Army Med Ctr, Dept Nephrol, Washington, DC 20307 USA.
[Baker, Thomas P.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA.
[Arbogast, Charles B.] William Beaumont Army Med Ctr, Dept Nephrol, El Paso, TX 79920 USA.
[Owshalimpur, David] Madigan Army Med Ctr, Dept Nephrol, Tacoma, WA 98431 USA.
RP Olson, SW (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM Stephen.w.olson@us.army.mil
OI Abbott, Kevin/0000-0003-2111-7112
NR 35
TC 26
Z9 27
U1 0
U2 5
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD OCT
PY 2011
VL 22
IS 10
BP 1946
EP 1952
DI 10.1681/ASN.2010090928
PG 7
WC Urology & Nephrology
SC Urology & Nephrology
GA 834HW
UT WOS:000295951400022
PM 21868497
ER
PT J
AU White, JO
Mungan, CE
AF White, Jeffrey O.
Mungan, Carl E.
TI Measurement of upconversion in Er:YAG via z-scan
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Article
ID LASER
AB We demonstrate the use of the z-scan technique for measuring the upconversion coefficient in Er:YAG. The upconversion coefficient is found to be linearly proportional to the concentration for samples of concentration 0.5-3.0 at:%. A fit to four samples at room temperature yields a value of C-up = (2.0 +/- 0.5) x 10(-17) cm(3)/s/at:%. The coefficient at liquid-nitrogen temperatures is C-up = (9.5 +/- 2.4) x 10(-17) cm(3)/s/at:%. (C) 2011 Optical Society of America
C1 [White, Jeffrey O.] USA, Res Lab, Adelphi, MD 20783 USA.
[Mungan, Carl E.] USN Acad, Dept Phys, Annapolis, MD 21402 USA.
RP White, JO (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jeffrey.owen.white@us.army.mil
NR 11
TC 9
Z9 9
U1 1
U2 9
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD OCT
PY 2011
VL 28
IS 10
BP 2358
EP 2361
PG 4
WC Optics
SC Optics
GA 835OJ
UT WOS:000296045400009
ER
PT J
AU Kulkarni, OP
Alexander, VV
Kumar, M
Freeman, MJ
Islam, MN
Terry, FL
Neelakandan, M
Chan, A
AF Kulkarni, Ojas P.
Alexander, Vinay V.
Kumar, Malay
Freeman, Michael J.
Islam, Mohammed N.
Terry, Fred L., Jr.
Neelakandan, Manickam
Chan, Allan
TI Supercontinuum generation from similar to 1.9 to 4.5 mu m in ZBLAN fiber
with high average power generation beyond 3,8 mu m using a thulium-doped
fiber amplifier
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Article
ID OPTICAL PARAMETRIC OSCILLATOR; SILICA FIBERS; LASER; AMPLIFICATION;
SPECTROSCOPY; SCATTERING; PULSES; GAIN
AB A mid-IR supercontinuum (SC) fiber laser based on a thulium-doped fiber amplifier (TDFA) is demonstrated. A continuous spectrum extending from similar to 1.9 to 4.5 mu m is generated with similar to 0.7W time-average power in wavelengths beyond 3.8 mu m. The laser outputs a total average power of up to similar to 2.6W from similar to 8.5m length of ZrF(4)-BaF(2)-LaF(3)-AlF(3)-NaF (ZBLAN) fiber, with an optical conversion efficiency of similar to 9% from the TDFA pump to the mid-IR SC. Optimal efficiency in generating wavelengths beyond 3.8 mu m is achieved by reducing the losses in the TDFA stage and optimizing the ZBLAN fiber length. We demonstrate a novel (to our knowledge) approach of generating modulation instability-initiated SC starting from 1.55 mu m by splitting the spectral shifting process into two steps. In the first step, amplified approximately nanosecond-long 1.55 mu m laser diode pulses with similar to 2.5kW peak power generate a SC extending beyond 2.1 mu m in similar to 25m length of standard single-mode fiber (SMF). The similar to 2 mu m wavelength components at the standard SMF output are amplified in a TDFA and coupled into ZBLAN fiber leading to mid-IR SC generation. Up to similar to 270nm SC long wavelength edge extension and similar to 2.5x higher optical conversion efficiency to wavelengths beyond 3.8 mu m are achieved by switching an Er:Yb-based power amplifier stage with a TDFA. The laser also demonstrates scalability in the average output power with respect to the pulse repetition rate and the amplifier pump power. Numerical simulations are performed by solving the generalized nonlinear Schrodinger equation, which show the long wavelength edge of the SC to be limited by the loss in ZBLAN. (C) 2011 Optical Society of America
C1 [Kulkarni, Ojas P.; Alexander, Vinay V.; Kumar, Malay; Islam, Mohammed N.; Terry, Fred L., Jr.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Freeman, Michael J.; Islam, Mohammed N.] Omni Sci Inc, Ann Arbor, MI 48105 USA.
[Neelakandan, Manickam; Chan, Allan] USA, Commun Elect Res Dev & Engn Ctr, Intelligence & Informat Warfare Directorate CERDE, Aberdeen Proving Ground, MD 21005 USA.
RP Kulkarni, OP (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA.
EM ojaspk@umich.edu
OI Terry, Fred/0000-0002-0634-5005
FU U.S. Army [W15P7T-10-C-H606]; U.S. Air Force [FA9201-10-C-0110]
FX This work was funded in part by the U.S. Army under project contract
#W15P7T-10-C-H606 and the U.S. Air Force under project contract
#FA9201-10-C-0110. The authors would like to thank B. Samson at Nufern
for providing the gain fiber used in the experiments and C. Troutman at
3SAE Technologies and F. Martins at Nufern for input on splicing
procedures for LMA fibers.
NR 34
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Z9 89
U1 2
U2 38
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD OCT
PY 2011
VL 28
IS 10
BP 2486
EP 2498
PG 13
WC Optics
SC Optics
GA 835OJ
UT WOS:000296045400027
ER
PT J
AU Hammerbeck, CD
Hooper, JW
AF Hammerbeck, Christopher D.
Hooper, Jay W.
TI T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of
Hantavirus Pulmonary Syndrome
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; RESPIRATORY SYNCYTIAL VIRUS; VIRAL
HEMORRHAGIC-FEVER; RENAL SYNDROME; CARDIOPULMONARY SYNDROME;
NEPHROPATHIA-EPIDEMICA; PUUMALA-HANTAVIRUS; ANDES VIRUS; VE-CADHERIN;
TNF-ALPHA
AB Andes virus (ANDV) is associated with a lethal vascular leak syndrome in humans termed hantavirus pulmonary syndrome (HPS). In hamsters, ANDV causes a respiratory distress syndrome closely resembling human HPS. The mechanism for the massive vascular leakage associated with HPS is poorly understood; however, T cell immunopathology has been implicated on the basis of circumstantial and corollary evidence. Here, we show that following ANDV challenge, hamster T cell activation corresponds with the onset of disease. However, treatment with cyclophosphamide or specific T cell depletion does not impact the course of disease or alter the number of surviving animals, despite significant reductions in T cell number. These data demonstrate, for the first time, that T cells are not required for hantavirus pathogenesis in the hamster model of human HPS. Depletion of T cells from Syrian hamsters did not significantly influence early events in disease progression. Moreover, these data argue for a mechanism of hantavirus-induced vascular permeability that does not involve T cell immunopathology.
C1 [Hammerbeck, Christopher D.; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM jay.hooper@amedd.army.mil
OI Hooper, Jay/0000-0002-4475-0415
NR 90
TC 41
Z9 41
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD OCT
PY 2011
VL 85
IS 19
BP 9929
EP 9944
DI 10.1128/JVI.05356-11
PG 16
WC Virology
SC Virology
GA 837ZH
UT WOS:000296253900026
PM 21775442
ER
PT J
AU Taylor, S
Jones, KW
Herzog, GF
Hornig, CE
AF Taylor, Susan
Jones, Keith W.
Herzog, Gregory F.
Hornig, Claire E.
TI Tomography: A window on the role of sulfur in the structure of
micrometeorites
SO METEORITICS & PLANETARY SCIENCE
LA English
DT Article
ID STONY COSMIC SPHERULES; ANTARCTIC MICROMETEORITES; ATMOSPHERIC ENTRY;
ICE; MICROTOMOGRAPHY; COLLECTION; METEORITES; PETROLOGY
AB To determine the role played by sulfides in the formation of vesicles and FeNi metal beads, we mapped the locations and tabulated the numbers of sulfides, metal beads, and vesicles in 1583 sectioned micrometeorites (MMs) using conventional microscopy and in 190 whole MMs using synchrotron computed microtomography (SCMT). Both the section and the SCMT images show that sulfides melt, coalesce, and migrate to the MMs' surface. The decomposition of sulfides may occur during all these stages. Given the sulfide morphologies and compositions that we see in section, we think the breakdown of Ni sulfides produces the FeNi beads. The SCMT images show that metal beads are common in melted MMs, > 50% have them. Vesicles in porphyritic and scoriaceous MMs are also probably formed as sulfides decompose. Not only do sulfides abut the vesicles but also the temperatures at which sulfides decompose overlap those at which MM surfaces first melt and temporarily seal, suggesting that S gases could produce most of these vesicles. As the vesicle shapes and patterns of distribution differ among MM classes, tomography can be used to nondestructively screen for specific types of MMs. Tomography is a powerful tool for visualizing the three-dimensional distribution of metal beads, sulfides, mean densities, and vesicles in MMs.
C1 [Taylor, Susan; Hornig, Claire E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Jones, Keith W.] Brookhaven Natl Lab, Upton, NY 11973 USA.
[Herzog, Gregory F.] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA.
RP Taylor, S (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM susan.taylor@usace.army.mil
FU NASA [NNX08AY82G]; US Department of Energy [DE-AC02-98CH10886]
FX We thank our referees Dr. G. Flynn and Dr. G. Libourel for many helpful
suggestions. L. Fareria and S. Bennett are thanked for their assistance
in operating the NSLS beam line X2B. This work was partially supported
by NASA grant NNX08AY82G (G. F. H.) and by the US Department of Energy
under Contract No. DE-AC02-98CH10886. Use of the National Synchrotron
Light Source, Brookhaven National Laboratory, was supported by the US
Department of Energy, Office of Basic Energy Sciences.
NR 22
TC 12
Z9 12
U1 1
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1086-9379
J9 METEORIT PLANET SCI
JI Meteorit. Planet. Sci.
PD OCT
PY 2011
VL 46
IS 10
BP 1498
EP 1509
DI 10.1111/j.1945-5100.2011.01245.x
PG 12
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 837YB
UT WOS:000296247400005
ER
PT J
AU Almirall, J
Miziolek, A
AF Almirall, Jose
Miziolek, Andrzej
TI Review of the Third North American Symposium on Laser-Induced Breakdown
Spectroscopy (NASLIBS) 2011 Conference
SO SPECTROSCOPY
LA English
DT Article
AB Jose Almirall of Florida International University and Andrzej Miziolek of the US Army Research Laboratory present a review of the 2011 NASLIBS conference, which was held in Clearwater Beach, Florida, July 18-20.
C1 [Almirall, Jose] Florida Int Univ Miami, Miami, FL 33181 USA.
[Miziolek, Andrzej] USA, Res Lab, Adelphi, MD 20783 USA.
RP Almirall, J (reprint author), Florida Int Univ Miami, Miami, FL 33181 USA.
RI Almirall, Jose/D-1280-2010
OI Almirall, Jose/0000-0002-5257-7499
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ADVANSTAR COMMUNICATIONS INC
PI DULUTH
PA 131 W 1ST STREET, DULUTH, MN 55802 USA
SN 0887-6703
J9 SPECTROSCOPY-US
JI Spectroscopy
PD OCT
PY 2011
VL 26
IS 10
BP 48
EP 49
PG 2
WC Spectroscopy
SC Spectroscopy
GA 834JZ
UT WOS:000295956900005
ER
PT J
AU Chapman, JR
Norvell, DC
Hermsmeyer, JT
Bransford, RJ
DeVine, J
McGirt, MJ
Lee, MJ
AF Chapman, Jens R.
Norvell, Daniel C.
Hermsmeyer, Jeffrey T.
Bransford, Richard J.
DeVine, John
McGirt, Matthew J.
Lee, Michael J.
TI Evaluating Common Outcomes for Measuring Treatment Success for Chronic
Low Back Pain
SO SPINE
LA English
DT Article
DE chronic low back pain; outcomes; patient-reported; reliability;
responsiveness; spine surgery; validity
ID SICKNESS IMPACT PROFILE; HEALTH-STATUS MEASURE; DISABILITY;
QUESTIONNAIRE; VALIDITY; SF-36; FEAR
AB Study Design. Systematic review.
Objective. To identify, describe, and evaluate common outcome measures in patients with chronic low back pain (CLBP).
Summary of Background Data. The treatment of CLBP has been associated with multiple clinical challenges. Further complicating this is the myriad of outcome scores used to assess treatment of CLBP. These scores have been used to examine different domains of patient satisfaction and quality of life in the literature. Critical assessment of the frequency, parity, and the quality of these outcomes are essential to improve our understanding of CLBP.
Methods. A systematic review of the English-language literature was undertaken for articles published from January 2001 through December 31, 2010. Electronic databases and reference lists of key articles were searched to identify measures used to evaluate outcomes in six different domains in patients with CLBP. The titles and abstracts of the peer-reviewed literature of LBP were searched to determine which of these measures were most commonly reported in the literature and which have been validated in populations with CLBP.
Results. We identified 75 outcome measures cited to evaluate CLBP. Twenty-nine of these outcome measures were excluded because of only a single citation leaving 46 measures for the evaluation. The most commonly used functional outcomes were the Oswestry Disability Index, Roland Morris Disability Index, and range of motion. For pain, the Numeric Pain Rating Scale, Brief Pain Inventory, Pain Disability Index, McGill Pain Questionnaire, and visual analog scale were most commonly cited. For psychosocial function, the Fear Avoidance Beliefs Questionnaire, Tampa Scale for Kinesiophobia, and Beck Depression Inventory were most commonly used. For generic quality of life, short form 36, Nottingham Health Profile, short form 12, and Sickness Impact Profile were the most common measures. For objective measures, the work status/return to work, complications or adverse events, and medications used were the most commonly cited. For preference-based measures, the Euro-Quol 5 dimensions and short form 6 dimensions were most commonly cited. The validity, reliability, responsiveness, universality, and potential proprietary requirements are summarized for each.
Conclusion. Outcome measures should be routinely assessed in patients with CLBP. The choice of appropriate outcome measure should be influenced by the study objectives and design, as well as properties of the particular measure within the context of CLBP.
Clinical Recommendations. Recommendation 1: When selecting the appropriate outcome measures for clinical or research purposes, consider domains that best measure what are most important to patients. Measures that are valid, reliable, and responsive to change should be considered first. Other considerations include the number of items required (especially in the context of multiple measures), whether the measure is validated in the relevant language, and the associated costs or fees. Strength: Strong Recommendation 2: Domains of greatest importance include pain, function, and quality of life. If cost utilization is a priority, then preference-based measures should be considered. For pain, we recommend the VAS and NRPS because of their ease of administration and responsiveness. For function, we recommend the ODI and RMDQ. The SF-36 and its shorter versions are most commonly used and should be considered if quality of life is important. If cost utility is important, consider the EQ-5D or SF-6D. Psychosocial tests are best used as screening tools prior to surgery because of their lack of responsiveness. Complications should always be assessed as a standard of clinical practice. Return to work and medication use are complicated outcome measures and not recommended unless the specific study question is focused on these domains. Consider staff and patient burden when prioritizing one's battery of measures.
C1 [Lee, Michael J.] Univ Washington, Dept Orthopaed Surg, Med Ctr, Seattle, WA 98195 USA.
[Chapman, Jens R.; Bransford, Richard J.] Univ Washington, Harborview Med Ctr, Dept Orthopaed Surg, Seattle, WA 98104 USA.
[Norvell, Daniel C.; Hermsmeyer, Jeffrey T.] Spectrum Res Inc, Tacoma, WA USA.
[DeVine, John] Eisenhower Army Med Ctr, Dept Spine Surg, Ft Gordon, GA USA.
[DeVine, John] Eisenhower Army Med Ctr, Dept Orthoped Residency, Ft Gordon, GA USA.
[McGirt, Matthew J.] Vanderbilt Univ, Med Ctr, Dept Neurosurg, Nashville, TN USA.
RP Lee, MJ (reprint author), Univ Washington, Dept Orthopaed Surg, Med Ctr, Box 356500,1959 Pacific Ave NE, Seattle, WA 98195 USA.
EM mjl3000@uw.edu
RI Comba, Valentina/G-6210-2014
FU AOSpine North America
FX Analytic support for this work was provided by Spectrum Research, Inc.,
with funding from the AOSpine North America.
NR 18
TC 99
Z9 100
U1 2
U2 34
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD OCT 1
PY 2011
VL 36
IS 21
SU S
BP S54
EP S68
DI 10.1097/BRS.0b013e31822ef74d
PG 15
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 835WN
UT WOS:000296067700005
PM 21952190
ER
PT J
AU DeVine, J
Norvell, DC
Ecker, E
Fourney, DR
Vaccaro, A
Wang, J
Andersson, G
AF DeVine, John
Norvell, Daniel C.
Ecker, Erika
Fourney, Daryl R.
Vaccaro, Alex
Wang, Jeff
Andersson, Gunnar
TI Evaluating the Correlation and Responsiveness of Patient-Reported Pain
With Function and Quality-of-Life Outcomes After Spine Surgery
SO SPINE
LA English
DT Article
DE spine surgery; pain; quality of life; outcomes
ID SCORES; FUSION
AB Study Design. Systematic review.
Objective. To determine the correlation of patient-reported pain with physical function and health-related quality of life (HRQoL) after spine surgery and to determine the responsiveness of pain, physical function, and HRQoL after spine surgery.
Summary of Background Data. Several validated outcome instruments are available to assess the success of treatment for chronic low back pain. These patient-centered tools include measurements for pain based on numeric scales, validated condition-specific functional outcomes measures, and HRQoL outcomes measures. It is unclear whether these three types of patient-reported outcomes are measuring different constructs and whether all three should be measured after spine surgery. In addition, it is unclear which of these outcomes measures is most sensitive to change after spine surgery for low back pain.
Methods. A systematic search was conducted in MEDLINE, EMBASE, and the Cochrane Collaboration Library for literature published through December 2010. The correlation between pain (visual analog scale, VAS), physical function (Oswestry Disability Index, ODI), and HRQoL (36-Item Short Form Health Survey [SF-36] and European Quality of Life [EQ-5D]) change scores was performed using the Spearman rank correlation coefficients. To compare the responsiveness of pain, function, and HRQoL scores after spine surgery, we calculated effect sizes by dividing change scores by the SD of the baseline scores. This standardized method allowed us to compare the responsiveness of each outcome measure directly and reported an effect size of 0.2 to 0.3 as a "small" effect, around 0.5 a "medium" effect and 0.8 to infinity, a "large" effect. To determine whether the differences in effect sizes measuring responsiveness were significantly different, we conducted a Wilcoxon signed-rank test between each of the three measurements of pain, function, and HRQoL scores when there was enough data to perform the test.
Results. None of the correlations exceeded 0.70 using the Spearman rank correlation coefcients, suggesting that these outcomes are measuring different constructs. The strongest correlations were between the VAS back pain change scores and the SF-36 physical composite score change scores (rho = 0.67) and VAS back pain change scores and ODI change scores (rho = 0.69). The pooled mean effect sizes for the five studies that reported a pain measure and the ODI were 1.4 +/- 0.57 and 1.1 +/- 0.39, respectively. Both are considered "large" effect sizes. The pooled mean effect sizes for the three studies reporting the SF-36 physical and mental composite scores were 0.66 +/- 0.39 and 0.54 +/- 0.36, respectively. Both are considered "medium" effect sizes. The pooled mean effect sizes for the single studies reporting the EQ-5D and SF-36 total score were 0.78 +/- 0.12 and 0.34 +/- 0.21. These were "medium" and "small," respectively.
Conclusion. We observed little correlation between the change in pain and the change in HRQoL outcomes measures. The strongest correlation was between VAS pain and ODI but was still not considered strong (0.69). These findings suggest that these three outcomes (pain, function, and HRQoL) are measuring different constructs. With respect to responsiveness, VAS pain and ODI were the only outcomes measures that demonstrated a large effect after lumbar spine surgery. None of the HRQoL tools were as sensitive to the treatment. The EQ-5D, SF physical composite, and SF mental composite outcomes demonstrated a medium effect, while the SF-36 total score demonstrated a small effect. The responsive measure shows that the more specific the outcomes tool, the more sensitive the response.
Clinical Recommendations. Recommendation 1: When surgically treating CLBP, we recommend administering both a VAS for pain and a condition-specific physical measure such as the ODI before and after surgical intervention as these outcomes are the most treatment specific and responsive to change. Strength of recommendation: Strong. Recommendation 2: When evaluating the surgical outcomes for CLBP in the clinical-research setting, we recommend selecting a shorter version for measuring general HRQoL (e.g., SF-12, EQ-5D) to minimize clinician and patient burden. Strength of recommendation: Strong.
C1 [DeVine, John] Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
[Norvell, Daniel C.; Ecker, Erika] Spectrum Res Inc, Tacoma, WA USA.
[Fourney, Daryl R.] Univ Saskatchewan, Royal Univ Hosp, Div Neurosurg, Saskatoon, SK, Canada.
[Vaccaro, Alex] Thomas Jefferson Univ Hosp, Rothman Inst, Dept Orthopaed & Neurosurg, Spine Div, Philadelphia, PA 19107 USA.
[Wang, Jeff] UCLA Spine Ctr, Santa Monica, CA USA.
[Andersson, Gunnar] Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA.
RP DeVine, J (reprint author), Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
EM john-devine@comcast.net
RI AOCID, AO Foundation/R-6455-2016
FU AOSpine North America
FX Analytic support for this work was provided by Spectrum Research, Inc.,
with funding from the AOSpine North America.
NR 9
TC 46
Z9 46
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD OCT 1
PY 2011
VL 36
IS 21
SU S
BP S69
EP S74
DI 10.1097/BRS.0b013e31822ef6de
PG 6
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 835WN
UT WOS:000296067700006
PM 21897347
ER
PT J
AU Aboud, S
Munseri, P
Joachim, A
Bakari, M
Nilsson, C
Buma, D
Aris, EA
Eligius, LF
Andreas, B
Robb, M
Marovich, M
Michael, N
Wahren, B
Biberfeld, G
Mhalu, F
Sandstrom, E
AF Aboud, S.
Munseri, P.
Joachim, A.
Bakari, M.
Nilsson, C.
Buma, D.
Aris, E. A.
Eligius, L. F.
Andreas, B.
Robb, M.
Marovich, M.
Michael, N.
Wahren, B.
Biberfeld, G.
Mhalu, F.
Sandstrom, E.
TI Persistence of Vaccine-Induced Antibodies Following HIV-1 DNA Prime MVA
Boost Vaccination Among Healthy Tanzanian Volunteers
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Aboud, S.] Muhimbili Univ, Coll Hlth Sci, Dar Es Salaam, Tanzania.
[Munseri, P.; Sandstrom, E.] Karolinska Inst, Stockholm, Sweden.
[Joachim, A.; Bakari, M.; Nilsson, C.; Eligius, L. F.; Mhalu, F.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
[Buma, D.] Muhimbili Natl Hosp, Dar Es Salaam, Tanzania.
[Andreas, B.; Biberfeld, G.] Swedish Inst Communicable Dis Control, Solna, Sweden.
[Robb, M.; Marovich, M.] Walter Reed Army Inst Res, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A75
EP A75
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500189
ER
PT J
AU Alpert, MD
Harvey, JD
Neidermyer, WJ
Huang, Y
Morris, D
Harris, L
Gao, H
Montefiori, DC
Pitisuttithum, P
Kaewkungwal, J
Nitayaphan, S
Rerks-Ngarm, S
Michael, NL
Kim, JH
Evans, DT
AF Alpert, M. D.
Harvey, J. D.
Neidermyer, W. J.
Huang, Y.
Morris, D.
Harris, L.
Gao, H.
Montefiori, D. C.
Pitisuttithum, P.
Kaewkungwal, J.
Nitayaphan, S.
Rerks-Ngarm, S.
Michael, N. L.
Kim, J. H.
Evans, D. T.
TI ADCC Titers to HIV-Infected Cells Are Detectable in the Majority of
Vaccine Recipients in the RV144 Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Huang, Y.; Morris, D.; Harris, L.] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA.
[Gao, H.; Montefiori, D. C.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
[Pitisuttithum, P.; Kaewkungwal, J.] Mahidol Univ, Bangkok 10700, Thailand.
[Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Michael, N. L.; Kim, J. H.] Walter Reed Army Inst Res, Nonthaburi, Thailand.
[Alpert, M. D.; Harvey, J. D.; Neidermyer, W. J.; Evans, D. T.] Harvard Univ, Sch Med, Southborough, MA 01772 USA.
RI Morris, Daryl/H-2659-2013
NR 0
TC 0
Z9 0
U1 0
U2 5
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A20
EP A21
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500050
ER
PT J
AU Billings, EA
Karasavvas, N
de Souza, MS
Currier, J
Pitisuttithum, P
Kaewkunwal, J
Nitayaphan, S
Gilbert, PB
Tomaras, GD
Zolla-Pazner, SB
Haynes, BF
Michael, NL
Rerks-Ngarm, S
Kim, JH
Rao, M
AF Billings, E. A.
Karasavvas, N.
de Souza, M. S.
Currier, J.
Pitisuttithum, P.
Kaewkunwal, J.
Nitayaphan, S.
Gilbert, P. B.
Tomaras, G. D.
Zolla-Pazner, S. B.
Haynes, B. F.
Michael, N. L.
Rerks-Ngarm, S.
Kim, J. H.
Rao, M.
TI Surface Plasmon Resonance Analysis of Anti-gp120 V2-Specific IgG
Antibodies Generated in the RV144 Thai Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Billings, E. A.; Currier, J.] HJF, USMHRP, Rockville, MD USA.
[Karasavvas, N.; de Souza, M. S.] AFRIMS, Bangkok, Thailand.
[Pitisuttithum, P.; Kaewkunwal, J.] Mahidol Univ, Bangkok 10700, Thailand.
[Gilbert, P. B.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Tomaras, G. D.; Haynes, B. F.] Duke Univ, Sch Med, Durham, NC 27706 USA.
[Zolla-Pazner, S. B.] NYU, New York, NY USA.
[Michael, N. L.; Kim, J. H.; Rao, M.] Walter Reed Army Inst Res, USMHRP, Rockville, MD USA.
[Rerks-Ngarm, S.] Minist Publ Hlth, Bangkok, Thailand.
RI Tomaras, Georgia/J-5041-2016
NR 0
TC 0
Z9 0
U1 0
U2 5
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A21
EP A22
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500052
ER
PT J
AU Charuthamrong, P
Kaeratiswetanun, W
Yamkram, T
Benenson, MW
Morgan, PA
Nitayaphan, S
Eamsila, C
Tungsakul, V
Sriplienchan, S
Robb, M
Thaitawat, N
AF Charuthamrong, P.
Kaeratiswetanun, W.
Yamkram, T.
Benenson, M. W.
Morgan, P. A.
Nitayaphan, S.
Eamsila, C.
Tungsakul, V.
Sriplienchan, S.
Robb, M.
Thaitawat, N.
TI Challenges in Consenting Sex Workers, Transgenders and Men Who Have Sex
with Men into an HIV Acute Infection Study in Pattaya, Thailand
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Charuthamrong, P.; Kaeratiswetanun, W.; Yamkram, T.; Benenson, M. W.; Morgan, P. A.; Nitayaphan, S.; Eamsila, C.; Tungsakul, V.; Sriplienchan, S.; Thaitawat, N.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Robb, M.] US Mil HIV Res Program, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A55
EP A56
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500138
ER
PT J
AU Currier, JR
Ratto-Kim, S
Ngauy, V
Ake, J
Lau, C
Doris, T
Herrera, E
David, WB
Sardesai, NY
Boyer, J
Khan, AS
Lee, J
Bagarazzi, M
Yan, J
Adams, E
Earl, P
Moss, B
Kim, J
Michael, N
Robb, M
Marovich, MA
AF Currier, J. R.
Ratto-Kim, S.
Ngauy, V.
Ake, J.
Lau, C.
Doris, T.
Herrera, E.
David, W. B.
Sardesai, N. Y.
Boyer, J.
Khan, A. S.
Lee, J.
Bagarazzi, M.
Yan, J.
Adams, E.
Earl, P.
Moss, B.
Kim, J.
Michael, N.
Robb, M.
Marovich, M. A.
TI Cell-Mediated Immune Responses After DNA Delivered by Either Biojector
or Electroporation and Boosted with a Heterologous Insert Recombinant
Poxvirus
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Currier, J. R.; Ratto-Kim, S.; Ake, J.; Lau, C.; Doris, T.; Herrera, E.; Kim, J.; Michael, N.; Robb, M.; Marovich, M. A.] Mil HIV Res Program, Rockville, MD USA.
[Ngauy, V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[David, W. B.; Boyer, J.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
[Adams, E.] NIAID, Div Aids, Bethesda, MD 20892 USA.
[Earl, P.; Moss, B.] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A3
EP A4
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500003
ER
PT J
AU Franchini, G
Pegu, P
Vaccari, M
Gordon, S
Keele, B
Doster, M
Guan, Y
Ferrari, G
Montefiori, D
Venzon, D
Fenizia, C
Lifson, J
Michael, N
Kim, J
Tartaglia, J
AF Franchini, G.
Pegu, P.
Vaccari, M.
Gordon, S.
Keele, B.
Doster, M.
Guan, Y.
Ferrari, G.
Montefiori, D.
Venzon, D.
Fenizia, C.
Lifson, J.
Michael, N.
Kim, J.
Tartaglia, J.
TI Titered Mucosal Challenge of Rhesus Macaques with SIVmac251
Recapitulates HIV Vaccine Efficacy in Humans
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Venzon, D.] NCI, Biostat & Data Management Sect, NIH, Bethesda, MD 20892 USA.
[Keele, B.] NCI Frederick, AIDS & Canc Virus Program, Frederick, MD USA.
[Guan, Y.] Univ Maryland, Human Monoclonal Antibody Core Lab, College Pk, MD 20742 USA.
[Ferrari, G.; Montefiori, D.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
[Lifson, J.] NCI, Human Retrovirus Sect, NIH, Bethesda, MD 20892 USA.
[Michael, N.; Kim, J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A4
EP A4
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500004
ER
PT J
AU Kopycinski, J
Cheeseman, H
Ashraf, A
Gill, DK
Hayes, P
De Souza, M
Fast, P
Cox, JH
Hannaman, D
Gilmour, J
Vasan, S
AF Kopycinski, J.
Cheeseman, H.
Ashraf, A.
Gill, D. K.
Hayes, P.
De Souza, M.
Fast, P.
Cox, J. H.
Hannaman, D.
Gilmour, J.
Vasan, S.
TI In Vivo Electroporation Induces Broad HIV-1 Envelope Epitope Responses
to ADVAX HIV-1 DNA Vaccine in Humans
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Kopycinski, J.; Cheeseman, H.; Ashraf, A.; Gill, D. K.; Hayes, P.; Fast, P.; Cox, J. H.; Gilmour, J.] Int AIDS Vaccine Initiat, London, England.
[De Souza, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Hannaman, D.] Ichor Med Syst Inc, San Diego, CA USA.
[Vasan, S.] Aaron Diamond AIDS Res Ctr, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A128
EP A128
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500331
ER
PT J
AU Leelawiwat, W
Rutvisuttinunt, W
McNicholl, J
Arroyo, M
Raengsakulrach, B
Mueanpai, F
Kongpechsatit, O
Assawadarachai, V
de Souza, M
Chaikummao, S
Chonwattana, W
Tongtoyai, J
Sangiamkittikul, A
Curlin, M
van Griensven, F
AF Leelawiwat, W.
Rutvisuttinunt, W.
McNicholl, J.
Arroyo, M.
Raengsakulrach, B.
Mueanpai, F.
Kongpechsatit, O.
Assawadarachai, V.
de Souza, M.
Chaikummao, S.
Chonwattana, W.
Tongtoyai, J.
Sangiamkittikul, A.
Curlin, M.
van Griensven, F.
TI Characterization of HIV-1 Subtype Distribution Among Thai MSM Using
MHAbce, a High Throughput Approach for Molecular Epidemiology Studies
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Leelawiwat, W.; Raengsakulrach, B.; Mueanpai, F.; Kongpechsatit, O.; Chaikummao, S.; Chonwattana, W.; Tongtoyai, J.; Sangiamkittikul, A.] US CDC Collaborat, Thailand Minist Publ Health, Nonthaburi, Thailand.
[Rutvisuttinunt, W.; Arroyo, M.; Assawadarachai, V.; de Souza, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[McNicholl, J.; Curlin, M.; van Griensven, F.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A114
EP A114
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500295
ER
PT J
AU Logan, M
Hertz, T
Edlefsen, PT
DeCamp, A
Magaret, C
Rademeyer, C
Rolland, M
Larsen, BB
Frahm, N
Marais, J
Thebus, R
Treurnicht, F
Zhao, H
Stoddard, J
Konopa, P
Nariya, S
Lam, A
Hural, J
Corey, L
Kublin, J
Gray, G
McElrath, MJ
Gilbert, P
Mullins, JI
Williamson, C
AF Logan, M.
Hertz, T.
Edlefsen, P. T.
DeCamp, A.
Magaret, C.
Rademeyer, C.
Rolland, M.
Larsen, B. B.
Frahm, N.
Marais, J.
Thebus, R.
Treurnicht, F.
Zhao, H.
Stoddard, J.
Konopa, P.
Nariya, S.
Lam, A.
Hural, J.
Corey, L.
Kublin, J.
Gray, G.
McElrath, M. J.
Gilbert, P.
Mullins, J. I.
Williamson, C.
TI HVTN503/Phambili Vaccine Trial: The effect of the HIV-1 Clade B-Based
Vaccine on Breakthrough Founder Viruses from a Clade C Infected
Population
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Logan, M.; Rademeyer, C.; Marais, J.; Thebus, R.; Treurnicht, F.; Williamson, C.] Univ Cape Town, ZA-7925 Cape Town, South Africa.
[Hertz, T.; Edlefsen, P. T.; DeCamp, A.; Magaret, C.; Frahm, N.; Hural, J.; Corey, L.; Kublin, J.; McElrath, M. J.; Gilbert, P.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Rolland, M.; Larsen, B. B.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Zhao, H.; Stoddard, J.; Konopa, P.; Nariya, S.; Lam, A.; Mullins, J. I.] Univ Washington, Seattle, WA 98195 USA.
[Gray, G.] Univ Witwatersrand, Johannesburg, South Africa.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A132
EP A132
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500343
ER
PT J
AU Matyas, GR
Alving, CR
AF Matyas, G. R.
Alving, C. R.
TI Antigen-Specific Enhancement of Natural Human IgG Antibodies to Lipids
Induced by a Liposomal Vaccine Containing Lipid A and a Protein Antigen
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Matyas, G. R.; Alving, C. R.] Walter Reed Army Inst Res, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A37
EP A37
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500087
ER
PT J
AU Oballah, PO
Flach, B
Eller, LA
Eller, MA
Ouma, BJ
Souza, MD
Guwatudde, D
Wabwire-Mangen, F
Brown, BK
Michael, NL
Robb, ML
Montefiori, D
Polonis, VR
AF Oballah, P. O.
Flach, B.
Eller, L. A.
Eller, M. A.
Ouma, B. J.
Souza, M. D.
Guwatudde, D.
Wabwire-Mangen, F.
Brown, B. K.
Michael, N. L.
Robb, M. L.
Montefiori, D.
Polonis, V. R.
TI B Cell Depletion in HIV-1 Subtype A Infected Ugandan Adults:
Relationship to CD4 Count, Viral Load and Humoral Immune Responses
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Oballah, P. O.; Flach, B.; Ouma, B. J.; Guwatudde, D.] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Eller, L. A.; Eller, M. A.; Brown, B. K.; Michael, N. L.; Robb, M. L.; Polonis, V. R.] US Mil HIV Res Program, Rockville, MD USA.
[Souza, M. D.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Wabwire-Mangen, F.] Makerere Univ, Sch Publ Hlth, Kampala, Uganda.
[Montefiori, D.] Duke Univ, Durham, NC 27706 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A43
EP A44
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500104
ER
PT J
AU Peachman, KK
Jobe, O
Wieczorek, L
Asher, L
Polonis, VR
Rao, V
Alving, CR
Rao, M
AF Peachman, K. K.
Jobe, O.
Wieczorek, L.
Asher, L.
Polonis, V. R.
Rao, V.
Alving, C. R.
Rao, M.
TI Liposomes Containing Glucosyl Ceramide and the Adjuvant Monophosphoryl
Lipid A Specifically Bind T4 Bacteriophage: A Self-Assembling
Nanocarrier
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Peachman, K. K.; Jobe, O.; Wieczorek, L.] US Mil HIV Res Program, Henry M Jackson Fdn, Rockville, MD USA.
[Asher, L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Polonis, V. R.; Alving, C. R.; Rao, M.] US Mil HIV Res Pro, Walter Reed Army Inst Res, Rockville, MD USA.
[Rao, V.] Catholic Univ Amer, Washington, DC 20064 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A37
EP A37
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500086
ER
PT J
AU Pitisuttithum, P
Rerks-Ngarm, S
Bussaratid, V
Dhitavat, J
Maekanantawat, W
Pungpak, S
Suntharasamai, P
Vanijanonta, S
Nitayapan, S
Kaewkungwal, J
Chunsuttiwat, S
Premsri, N
Benenson, M
Morgan, P
Berenberg, J
Gurunathan, S
Francis, DP
Chiu, J
Excler, J
Robb, ML
Stablein, D
Michael, NL
Kim, J
AF Pitisuttithum, P.
Rerks-Ngarm, S.
Bussaratid, V.
Dhitavat, J.
Maekanantawat, W.
Pungpak, S.
Suntharasamai, P.
Vanijanonta, S.
Nitayapan, S.
Kaewkungwal, J.
Chunsuttiwat, S.
Premsri, N.
Benenson, M.
Morgan, P.
Berenberg, J.
Gurunathan, S.
Francis, D. P.
Chiu, J.
Excler, J.
Robb, M. L.
Stablein, D.
Michael, N. L.
Kim, J.
TI Safety and Reactogenicity of ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX
B/E Prime-Boost Vaccination Regimen in a Community-Based Efficacy Trial
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Pitisuttithum, P.; Bussaratid, V.; Dhitavat, J.; Maekanantawat, W.; Pungpak, S.; Suntharasamai, P.; Vanijanonta, S.; Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand.
[Nitayapan, S.; Benenson, M.; Morgan, P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Berenberg, J.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Gurunathan, S.] Sanofi Pasteur, Swiftwater, PA USA.
[Francis, D. P.] Global Solut Infect Dis, San Francisco, CA USA.
[Excler, J.; Robb, M. L.; Kim, J.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA.
[Stablein, D.] EMMES Corp, Rockville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A74
EP A74
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500186
ER
PT J
AU Rao, M
Jobe, O
Peachman, KK
Matyas, GR
Asher, LV
Alving, CR
AF Rao, M.
Jobe, O.
Peachman, K. K.
Matyas, G. R.
Asher, L. V.
Alving, C. R.
TI Inhibition of Human Immunodeficiency Virus Type 1 Infection of Human
Monocyte-Derived Macrophages by Anti-Lipid and Anti-MPER Monoclonal
Antibodies
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Rao, M.; Matyas, G. R.; Alving, C. R.] USMHRP, Walter Reed Army Inst Res, Rockville, MD USA.
[Jobe, O.; Peachman, K. K.] USMHRP, HJF, Rockville, MD USA.
[Asher, L. V.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A6
EP A7
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500011
ER
PT J
AU Valenzuela, AB
Morgan, P
Benenson, M
Sriplienchan, S
Thaitawat, N
Buapunth, P
Pumratana, K
Kim, J
Michael, N
Robb, M
AF Valenzuela, A. Bolen
Morgan, P.
Benenson, M.
Sriplienchan, S.
Thaitawat, N.
Buapunth, P.
Pumratana, K.
Kim, J.
Michael, N.
Robb, M.
TI Risk Behavior and Demographic Characteristics of Infected vs
Non-Infected Participants in RV217d, a Study in At-Risk Populations in
Pattaya, Thailand
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on AIDS Vaccine
CY SEP 12-15, 2011
CL Bangkok, THAILAND
C1 [Valenzuela, A. Bolen; Kim, J.; Michael, N.; Robb, M.] US Mil HIV Res Program, Rockville, MD USA.
[Morgan, P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Benenson, M.; Sriplienchan, S.; Thaitawat, N.; Buapunth, P.; Pumratana, K.] AFRIMS, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2011
VL 27
IS 10
BP A34
EP A35
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 832GD
UT WOS:000295790500079
ER
PT J
AU Sagripanti, JL
Hulseweh, B
Grote, G
Voss, L
Bohling, K
Marschall, HJ
AF Sagripanti, Jose-Luis
Huelseweh, Birgit
Grote, Gudrun
Voss, Luzie
Boehling, Katrin
Marschall, Hans-Juergen
TI Microbial Inactivation for Safe and Rapid Diagnostics of Infectious
Samples
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID VENEZUELAN-EQUINE-ENCEPHALITIS; CHAIN-REACTION PCR;
MONOCLONAL-ANTIBODIES; VIRUSES; SENSITIVITY; COMPLEX; COPPER; ELISA
AB The high risk associated with biological threat agents dictates that any suspicious sample be handled under strict surety and safety controls and processed under high-level containment in specialized laboratories. This study attempted to find a rapid, reliable, and simple method for the complete inactivation of a wide range of pathogens, including spores, vegetative bacteria, and viruses, while preserving microbial nucleic acid fragments suitable for PCRs and proteinaceous epitopes for detection by immunoassays. Formaldehyde, hydrogen peroxide, and guanidium thiocyanate did not completely inactivate high titers of bacterial spores or viruses after 30 min at 21 degrees C. Glutaraldehyde and sodium hypochlorite showed high microbicidal activity but obliterated the PCR or enzyme-linked immunosorbent assay (ELISA) detection of bacterial spores or viruses. High-level inactivation (more than 6 log(10)) of bacterial spores (Bacillus atrophaeus), vegetative bacteria (Pseudomonas aeruginosa), an RNA virus (the alphavirus Pixuna virus), or a DNA virus (the orthopoxvirus vaccinia virus) was attained within 30 min at 21 degrees C by treatment with either peracetic acid or cupric ascorbate with minimal hindrance of subsequent PCR tests and immunoassays. The data described here should provide the basis for quickly rendering field samples noninfectious for further analysis under lower-level containment and considerably lower cost.
C1 [Huelseweh, Birgit; Grote, Gudrun; Voss, Luzie; Boehling, Katrin; Marschall, Hans-Juergen] WIS, ABC Schutz, Munster, Germany.
[Sagripanti, Jose-Luis] USA, Edgewood Chem Biol Ctr, Aberdeen, MD USA.
RP Marschall, HJ (reprint author), German Fed Army, Wehrwissensch Inst Schutztechnol ABC, Schutz Sci Inst Protect Technol, NBC Protect, POB 1142, D-29623 Munster, Germany.
EM hansjuergenmarschall@bwb.org
NR 28
TC 11
Z9 12
U1 1
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD OCT
PY 2011
VL 77
IS 20
BP 7289
EP 7295
DI 10.1128/AEM.05553-11
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 832VJ
UT WOS:000295836700027
PM 21856830
ER
PT J
AU Warner, CH
Appenzeller, GN
Grieger, T
Belenkiy, S
Breitbach, J
Parker, J
Warner, CM
Hoge, C
AF Warner, Christopher H.
Appenzeller, George N.
Grieger, Thomas
Belenkiy, Slava
Breitbach, Jill
Parker, Jessica
Warner, Carolynn M.
Hoge, Charles
TI Importance of Anonymity to Encourage Honest Reporting in Mental Health
Screening After Combat Deployment
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; MILLENNIUM COHORT; MILITARY COHORT; PTSD
CHECKLIST; SOLDIERS; CARE; ATTITUDES; IRAQ; AFGHANISTAN; DEPRESSION
AB Context: US soldiers are required to undergo screening for depression, posttraumatic stress disorder (PTSD), and other mental health problems on return from service in Iraq or Afghanistan as part of routine postdeployment health assessments.
Objective: To assess the influence of the anonymity of screening processes on willingness of soldiers to report mental health problems after combat deployment.
Design: Anonymous and nonanonymous surveys.
Setting: US military.
Patients: US infantry soldiers' reporting of mental health problems on the routine Post-Deployment Health Assessment was compared with their reporting on an anonymous survey administered simultaneously.
Main Outcome Measures: The Primary Care PTSD Screen, the Patient Health Questionnaire-2 (modified), the suicidal ideation question from the Patient Health Questionnaire-9, and several other questions related to mental health were used on both surveys. Soldiers were also asked on the anonymous survey about perceptions of stigma and willingness to report honestly.
Results: Of 3502 US Army soldiers from one infantry brigade combat team undergoing the routine Post-Deployment Health Assessment in 2008, a total of 2500 were invited to complete the anonymous survey, and 1712 of these participated (response rate, 68.5%). Reporting of depression, PTSD, suicidal ideation, and interest in receiving care were 2-fold to 4-fold higher on the anonymous survey compared with the routine Post-Deployment Health Assessment. Overall, 20.3% of soldiers who screened positive for depression or PTSD reported that they were uncomfortable reporting their answers honestly on the routine postdeployment screening.
Conclusions: Current postdeployment mental health screening tools are dependent on soldiers honestly reporting their symptoms. This study indicates that the Post-Deployment Health Assessment screening process misses most soldiers with significant mental health problems. Further efforts are required to reduce the stigma of reporting and improve willingness to receive care for mental health problems.
C1 [Warner, Christopher H.] US Army Med Act Alaska, Clin Serv, Ft Wainwright, AK 99703 USA.
[Warner, Christopher H.] Command & Gen Staff Coll, Ft Wainwright, KS USA.
[Warner, Carolynn M.] Munson Army Hlth Clin, Ft Wainwright, KS USA.
[Grieger, Thomas] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
[Hoge, Charles] Walter Reed Army Inst Res, Ctr Psychiat & Neurosc, Silver Spring, MD USA.
[Belenkiy, Slava] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Breitbach, Jill] Evans Army Community Hosp, Behav Hlth Clin, Ft Carson, CO USA.
[Parker, Jessica] Winn Army Community Hosp, Warrior Restorat Ctr, Ft Stewart, GA USA.
RP Warner, CH (reprint author), US Army Med Act Alaska, Clin Serv, 1060 Gaffney Rd,Bldg 7400, Ft Wainwright, AK 99703 USA.
EM Christopher.H.Warner@us.army.mil
NR 38
TC 73
Z9 74
U1 1
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0003-990X
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD OCT
PY 2011
VL 68
IS 10
BP 1065
EP 1071
PG 7
WC Psychiatry
SC Psychiatry
GA 828FE
UT WOS:000295486100011
PM 21969463
ER
PT J
AU Hannah, ST
Avolio, BJ
Walumbwa, FO
AF Hannah, Sean T.
Avolio, Bruce J.
Walumbwa, Fred O.
TI Relationships between Authentic Leadership, Moral Courage, and Ethical
and Pro-Social Behaviors
SO BUSINESS ETHICS QUARTERLY
LA English
DT Article
ID WORK; MODEL; ORGANIZATIONS; CONCEPTIONS; PERSPECTIVE; ATTITUDES;
OUTCOMES; VALUES; BIAS
AB Organizations constitute morally-complex environments, requiring organization members to possess levels of moral courage sufficient to promote their ethical action, while refraining from unethical actions when faced with temptations or pressures. Using a sample drawn from a military context, we explored the antecedents and consequences of moral courage. Results from this four-month field study demonstrated that authentic leadership was positively related to followers' displays of moral courage. Further, followers' moral courage fully mediated the effects of authentic leadership on followers' ethical and pro-social behaviors. Theoretical and practical implications for further integrating the work on moral courage, authentic leadership and ethics are discussed.
C1 [Hannah, Sean T.] USA, Washington, DC 20310 USA.
[Hannah, Sean T.] Ctr Army Profess & Eth, West Point, NY USA.
[Avolio, Bruce J.] Univ Washington, Foster Sch Business, Ctr Leadership & Strateg Thinking, Seattle, WA 98195 USA.
[Walumbwa, Fred O.] Arizona State Univ, WP Carey Sch Business, Tempe, AZ 85287 USA.
[Walumbwa, Fred O.] Gallup Org Inc, Washington, DC USA.
RP Hannah, ST (reprint author), USA, Washington, DC 20310 USA.
EM Sean.hannah@usma.edu; bavolio@uwashington.edu; Fred.Walumbwa@asu.edu
NR 80
TC 49
Z9 50
U1 9
U2 82
PU PHILOSOPHY DOCUMENTATION CENTER
PI CHARLOTTESVILLE
PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA
SN 1052-150X
J9 BUS ETHICS Q
JI Bus. Ethics Q.
PD OCT
PY 2011
VL 21
IS 4
BP 555
EP 578
PG 24
WC Business; Ethics
SC Business & Economics; Social Sciences - Other Topics
GA 828IZ
UT WOS:000295496000002
ER
PT J
AU Jiang, RZ
Chu, DR
AF Jiang, Rongzhong
Chu, Deryn
TI An air-breathing H-2/air cell design suitable for fast screening of
electrolytes
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Air-breathing; Cell design; Alkaline electrolytes; Effect of CO2; Fuel
cell
ID ANION-EXCHANGE MEMBRANE; ALKALINE FUEL-CELLS; IONIC-CONDUCTIVITY;
PERFORMANCE; CATALYST
AB An air-breathing H-2/air cell was designed for fast screening of electrolytes. In this study various electrolytes, including organic, inorganic, acidic, and basic electrolytes, were screened by comparing their effect on cell discharge performance. Focusing on organic alkaline electrolytes, several tetraalkyl ammonium hydroxide electrolytes with different molecular size and concentrations were investigated at different operating temperatures. Both electrolyte concentration and operating temperature significantly affect the cell's performance. The effect of CO2 and some acids on alkaline electrolyte's impedance and cell's discharge performance was also investigated. Published by Elsevier Ltd.
C1 [Jiang, Rongzhong; Chu, Deryn] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Jiang, RZ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM rongzhong.jiang.civ@mail.mil
FU U.S. Department of Army; Army Materiel Command
FX The authors wish to thank the U.S. Department of Army and the Army
Materiel Command for support to this work, and Dr. Cynthia Lundgren for
review and helpful discussions.
NR 21
TC 2
Z9 2
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD OCT 1
PY 2011
VL 56
IS 24
BP 8365
EP 8370
DI 10.1016/j.electacta.2011.07.025
PG 6
WC Electrochemistry
SC Electrochemistry
GA 829RI
UT WOS:000295601600037
ER
PT J
AU Harrison, SA
Hamzeh, F
Han, J
Vierling, JM
AF Harrison, Stephen A.
Hamzeh, Fayez
Han, Jian
Vierling, John M.
TI EFFICACY, SAFETY, AND METABOLIC EFFECTS IN CHRONIC HEPATITIS C (CHC)
GENOTYPE 1 (G1) PATIENTS WITH INSULIN RESISTANCE (IR) TREATED WITH
PIOGLITAZONE (PIO) AND PEGINTERFERON ALFA-2A PLUS RIBAVIRIN (P/R)
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 04-08, 2011
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Hamzeh, Fayez; Han, Jian] Genentech Inc, Virol, San Francisco, CA 94080 USA.
[Vierling, John M.] Baylor Coll Med, Houston, TX 77030 USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2011
VL 54
SU 1
BP 439A
EP 439A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 829KG
UT WOS:000295578002161
ER
PT J
AU Lawitz, E
Poordad, FF
Bronowicki, JP
Marcellin, P
Feinman, VS
Kwo, PY
Guyader, D
Davis, M
Harrison, SA
Pedicone, L
Deng, WP
Burroughs, M
Brass, CA
Albrecht, JK
Zeuzem, S
AF Lawitz, Eric
Poordad, F. Fred
Bronowicki, Jean-Pierre
Marcellin, Patrick
Feinman, Victor S.
Kwo, Paul Y.
Guyader, Dominique
Davis, Mitchell
Harrison, Stephen A.
Pedicone, Lisa
Deng, Weiping
Burroughs, Margaret
Brass, Clifford A.
Albrecht, Janice K.
Zeuzem, Stefan
TI THE EFFECT OF USING LOWER LIMIT OF QUANTITATION (LLQ) VS LOWER LIMIT OF
DETECTION (LLD) FOR THE DEFINITION OF UNDETECTABLE HCV RNA: DATA FROM
THE RESPOND-2 AND SPRINT-2 TRIALS
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 04-08, 2011
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Lawitz, Eric] Alamo Med Res, San Antonio, TX USA.
[Poordad, F. Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Bronowicki, Jean-Pierre] Univ Nancy 1, Vandoeuvre Les Nancy, France.
[Marcellin, Patrick] Univ Paris 07, Hop Beaujon, Clichy, France.
[Feinman, Victor S.] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada.
[Kwo, Paul Y.] Indiana Univ Sch Med, Indianapolis, IN USA.
[Guyader, Dominique] Hop Pontchaillou, CHRU Rennes, Rennes, France.
[Davis, Mitchell] S Florida Ctr Gastroenterol, Wellington, FL USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Pedicone, Lisa; Deng, Weiping; Burroughs, Margaret; Brass, Clifford A.; Albrecht, Janice K.] Merck Sharp Dohme Corp, Whitehouse Stn, NJ USA.
[Zeuzem, Stefan] JW Goethe Univ Hosp, Frankfurt, Germany.
NR 0
TC 3
Z9 3
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2011
VL 54
SU 1
BP 442A
EP 443A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 829KG
UT WOS:000295578002167
ER
PT J
AU Shiffman, ML
Poordad, FF
Reddy, R
Afdhal, NH
Brown, RS
Flamm, SL
Harrison, SA
Noviello, S
Brass, CA
Pedicone, L
Albrecht, JK
Sulkowski, MS
AF Shiffman, Mitchell L.
Poordad, F. Fred
Reddy, Rajender
Afdhal, Nezam H.
Brown, Robert S.
Flamm, Steven L.
Harrison, Stephen A.
Noviello, Stephanie
Brass, Clifford A.
Pedicone, Lisa
Albrecht, Janice K.
Sulkowski, Mark S.
TI IMPACT OF IL28B GENOTYPE (GT) ON SUSTAINED VIROLOGIC RESPONSE (SVR) IN
PATIENTS (PTS) WHO REQUIRE PEGINTERFERON (PEG) AND/OR RIBAVIRIN (R) DOSE
MODIFICATION (DM) DURING HCV TREATMENT
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 04-08, 2011
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Shiffman, Mitchell L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA.
[Poordad, F. Fred] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Reddy, Rajender] Univ Penn, Philadelphia, PA 19104 USA.
[Afdhal, Nezam H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Brown, Robert S.] Columbia Univ, Med Ctr, New York, NY USA.
[Flamm, Steven L.] Northwestern Univ, Chicago, IL 60611 USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, San Antonio, TX USA.
[Noviello, Stephanie; Brass, Clifford A.; Pedicone, Lisa; Albrecht, Janice K.] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA.
[Sulkowski, Mark S.] Johns Hopkins Univ, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2011
VL 54
SU 1
BP 999A
EP 999A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 829KG
UT WOS:000295578003575
ER
PT J
AU Witzel, J
AF Witzel, John
TI my favorite experiment Exploring the World with Ultraviolet Light
SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE
LA English
DT Article
C1 [Witzel, John] Paladin S, Kandahar, Afghanistan.
[Witzel, John] USA, Washington, DC USA.
RP Witzel, J (reprint author), Paladin S, Kandahar, Afghanistan.
EM john.witzel@gmail.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1094-6969
J9 IEEE INSTRU MEAS MAG
JI IEEE Instrum. Meas. Mag.
PD OCT
PY 2011
VL 14
IS 5
BP 50
EP 51
PG 2
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA 832HC
UT WOS:000295793600008
ER
PT J
AU Behrend, C
Reizner, W
Marchessault, JA
Hammert, WC
AF Behrend, Caleb
Reizner, Wayne
Marchessault, Jeffrey A.
Hammert, Warren C.
TI Update on Advances in Upper Extremity Prosthetics
SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME
LA English
DT Article
ID TARGETED MUSCLE REINNERVATION; LIMB LOSS; AMPUTATIONS; CHILDREN; AMPUTEE
AB Upper extremity amputations are common. Fortunately, most of these involve loss of only a finger or portion thereof. Hand and upper limb surgeons are best suited to lead the team and help these patients following these injuries. Proximal amputations can be devastating for the patient, but recent prosthetic advances have helped many patients lead a better life and, often, return to activities they were involved in before their amputation. The purpose of this article is to review the current prostheses available for upper extremity amputees. (J Hand Surg 2011;36A:1711-1717. Copyright (C) 2011 by the American Society for Surgery of the Hand. All rights reserved.)
C1 Univ Rochester, Med Ctr, Dept Orthopaed Surg & Rehabil, Rochester, NY 14642 USA.
Walter Reed Army Med Ctr, Integrated Dept Orthoped & Rehabil, Washington, DC 20307 USA.
RP Hammert, WC (reprint author), 601 Elmwood Ave,Box 665, Rochester, NY 14642 USA.
EM Warren_Hammert@URMC.Rochester.edu
NR 17
TC 18
Z9 18
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0363-5023
J9 J HAND SURG-AM
JI J. Hand Surg.-Am. Vol.
PD OCT
PY 2011
VL 36A
IS 10
BP 1711
EP 1717
DI 10.1016/j.jhsa.2011.07.024
PG 7
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 833BC
UT WOS:000295855800026
PM 21971060
ER
PT J
AU Brown, MC
Creel, AH
Engel, CC
Herrell, RK
Hoge, CW
AF Brown, Mark C.
Creel, Alisha H.
Engel, Charles C.
Herrell, Richard K.
Hoge, Charles W.
TI Factors Associated With Interest in Receiving Help for Mental Health
Problems in Combat Veterans Returning From Deployment to Iraq
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Mental health care; social stigma; access to care; interest in care;
military
ID PERCEIVED STIGMA; PSYCHOMETRIC PROPERTIES; CARE; BARRIERS; SOLDIERS;
AFGHANISTAN; SEEKING; WAR
AB Mental health problems in service members often go untreated. This study focused on factors related to interest in receiving help in a survey sample of 577 combat veterans who were screened positive for posttraumatic stress disorder, depression, or generalized anxiety disorder 3 months after returning from Iraq. Over three quarters of respondents recognized that they had a current problem, but only 40% were interested in receiving help. Interest in receiving help was associated with recognizing a problem and receiving mental health services in the past year. More negative attitudes toward mental health care were associated with lower interest in receiving help; paradoxically, more negative perceptions of unit stigma were associated with increased interest in receiving help. Further studies are needed to better define the relationship between stigma perceptions, interest in receiving care, and actual care utilization and to determine whether attitudes toward mental health care can be modified through changes in how care is delivered. Attitudes toward mental health care should be considered in treatment interventions.
C1 [Herrell, Richard K.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Brown, Mark C.; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
[Creel, Alisha H.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 509 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
FU Military Operational Medicine Research Area Directorate, US Army Medical
Research and Materiel Command, Fort Detrick, MD
FX This research was funded by the Military Operational Medicine Research
Area Directorate, US Army Medical Research and Materiel Command, Fort
Detrick, MD.
NR 24
TC 31
Z9 31
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD OCT
PY 2011
VL 199
IS 10
BP 797
EP 801
DI 10.1097/NMD.0b013e31822fc9bf
PG 5
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 827BD
UT WOS:000295399300012
PM 21964275
ER
PT J
AU Nestrud, MA
Ennis, JM
Fayle, CM
Ennis, DM
Lawless, HT
AF Nestrud, Michael A.
Ennis, John M.
Fayle, Charles M.
Ennis, Daniel M.
Lawless, Harry T.
TI VALIDATING A GRAPH THEORETIC SCREENING APPROACH TO FOOD ITEM
COMBINATIONS
SO JOURNAL OF SENSORY STUDIES
LA English
DT Article
ID CONJOINT-ANALYSIS; CLIQUES; SCALE; PORK
AB Tools from the mathematical field of graph theory potentially allow the consumer scientist to efficiently analyze large numbers of combinations of food items, such as components on a salad. In this study, we tested the validity of such an approach. We began by asking subjects whether or not pairs of ingredients would be appropriate to combine on a salad. Next, using graph theoretic methods, we predicted which combinations of 3-8 components should go together, and perhaps more importantly, which combinations should not. Subjects were then asked whether or not particular combinations were appropriate to combine on a salad. A paired Wilcoxon test between the predicted and nonpredicted combinations was significant for all combination sizes.
C1 [Nestrud, Michael A.; Lawless, Harry T.] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA.
[Ennis, John M.; Fayle, Charles M.; Ennis, Daniel M.] Inst Percept, Richmond, VA USA.
[Nestrud, Michael A.] USA, Natick Soldier R, D&E Ctr, Natick, MA 01760 USA.
RP Nestrud, MA (reprint author), Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA.
EM mike@ataraxis.org
OI Nestrud, Michael/0000-0002-2423-6785
NR 34
TC 4
Z9 4
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-8250
J9 J SENS STUD
JI J. Sens. Stud.
PD OCT
PY 2011
VL 26
IS 5
BP 331
EP 338
DI 10.1111/j.1745-459X.2011.00348.x
PG 8
WC Food Science & Technology
SC Food Science & Technology
GA 833HK
UT WOS:000295873800004
ER
PT J
AU McCain, KNS
Wilson, GWT
Blair, JM
AF McCain, Kathryn N. S.
Wilson, Gail W. T.
Blair, J. M.
TI Mycorrhizal suppression alters plant productivity and forb establishment
in a grass-dominated prairie restoration
SO PLANT ECOLOGY
LA English
DT Article
DE Arbuscular mycorrhizal fungi; Fungicide; Forbs; Grassland restoration;
Warm-season grass
ID TALLGRASS PRAIRIE; ARBUSCULAR MYCORRHIZAE; RESOURCE AVAILABILITY;
COMMUNITY STRUCTURE; ORGANIC-MATTER; FUNGI; DIVERSITY; COMPETITION;
RESPONSES; COLONIZATION
AB A fundamental goal of restoration is the re-establishment of plant diversity representative of native vegetation. However, many prairie restorations or Conservation Reserve Program sites have been seeded with warm-season grasses, leading to grass-dominated, low-diversity restorations not representative of native grasslands. These dominant grasses are strongly mycotrophic, while many subordinate forb species appear to be less dependent on mycorrhizal symbiosis. Therefore, manipulating arbuscular mycorrhizal fungi (AMF) may be useful in promoting establishment and growth of forb species in grass-dominated prairie restorations. To assess the potential role of mycorrhizae in affecting the productivity and community composition of restored tallgrass prairie, we conducted a 4-year field experiment on an 8-year-old grassland restoration at the Konza Prairie in northeastern Kansas, USA. At the initiation of our study, seeds of 12 forb species varying in degree of mycorrhizal dependence were added to established grass-dominated plots. Replicate plots were treated biweekly with a soil drench of fungicide (Topsin-M (R)) over four growing seasons and compared to non-treated control plots to assess the role of AMF in affecting plant species composition, productivity, leaf tissue quality, and diversity in restored tallgrass prairie. Topsin applications successfully reduced mycorrhizal colonization of grass roots to approximately 60-80% relative to roots in control plots. Four years of mycorrhizal suppression reduced productivity of the dominant grasses and increased plant species richness and diversity. These results highlight the importance of mycorrhizae as mediators of plant productivity and community dynamics in restored tallgrass prairie and indicate that temporarily suppressing AMF decreases productivity of the dominant C4 grasses and allows for establishment of seeded forb species.
C1 [McCain, Kathryn N. S.] USA, Corps Engineers, St Louis, MO 63103 USA.
[Wilson, Gail W. T.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA.
[Blair, J. M.] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA.
RP McCain, KNS (reprint author), USA, Corps Engineers, 1222 Spruce St, St Louis, MO 63103 USA.
EM kathryn.mccain@usace.army.mil
RI Wilson, Gail/G-4255-2012; Blair, John/I-4082-2014
OI Blair, John/0000-0003-0072-0721
FU National Science Foundation [IBN-9632851]; Pizzo and Associates Ltd.,
Leland, IL.
FX This research was partially funded by the National Science Foundation
Long-term Ecological Research Program (Grant IBN-9632851) and by Jack
Pizzo from Pizzo and Associates Ltd., Leland, IL.
NR 38
TC 11
Z9 15
U1 6
U2 93
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1385-0237
EI 1573-5052
J9 PLANT ECOL
JI Plant Ecol.
PD OCT
PY 2011
VL 212
IS 10
BP 1675
EP 1685
DI 10.1007/s11258-011-9940-0
PG 11
WC Plant Sciences; Ecology; Forestry
SC Plant Sciences; Environmental Sciences & Ecology; Forestry
GA 834SG
UT WOS:000295983700009
ER
PT J
AU Weber, NS
Fisher, JA
Cowan, DN
Niebuhr, DW
AF Weber, Natalya S.
Fisher, Jared A.
Cowan, David N.
Niebuhr, David W.
TI Psychiatric and General Medical Conditions Comorbid With Bipolar
Disorder in the National Hospital Discharge Survey
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID SUBSTANCE USE DISORDERS; I-DISORDER; MAJOR DEPRESSION; ALLOSTATIC LOAD;
MENTAL-ILLNESS; WEIGHT-GAIN; PREVALENCE; EPIDEMIOLOGY; INDIVIDUALS;
DIAGNOSIS
AB Objective: From 40% to 65% of patients with bipolar disorder are estimated to have diagnoses of one or more comorbid conditions. The purpose of this study was to identify comorbid disorders and compare their prevalence in hospitalizations of persons with or without bipolar disorder. Methods: Data from the 1979-2006 National Hospital Discharge Survey (NHDS) were analyzed to examine temporal trends in the proportional morbidity of bipolar disorder, demographic characteristics, and the most frequent comorbid conditions in hospitalizations of patients with or without bipolar disorder. Among discharges of patients ages 13-64, the conditions of those with a primary diagnosis of bipolar disorder (N=27,054) were compared with those with other primary diagnoses (N=2,325,247). Proportional morbidity ratios (PMRs) were calculated. Results: There was an average 10% (p<.001) increase per year in the proportion of discharges with bipolar disorder. Proportions of discharge records that noted bipolar disorder were higher among females and whites and were highest among persons ages 13-19 and those from the Northeast. Discharge records noting a primary diagnosis of bipolar disorder showed higher proportions of most psychiatric and some general medical conditions, including acquired hypothyroidism (proportional morbidity ratio=2.6), viral hepatitis (1.6), obesity (1.4), and various diseases of the skin and subcutaneous tissue (range 2.6-4.2) and of the nervous (1.4-3.8), respiratory (1.4-2.3), and musculoskeletal (1.2-1.9) systems. Conclusions: Patients with bipolar disorder have an increased illness burden from many psychiatric and general medical conditions. Knowledge of the most prevalent comorbid conditions and methods for their prevention, early diagnosis, and treatment are critical in improving the prognosis of patients with bipolar disorder. (Psychiatric Services 62:1152-1158, 2011)
C1 [Weber, Natalya S.; Fisher, Jared A.; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
[Fisher, Jared A.; Cowan, David N.] Allied Technol Grp, Rockville, MD USA.
RP Weber, NS (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM natalya.weber@us.army.mil
FU Stanley Medical Research Institute (Bethesda, Maryland); U.S. Department
of the Army
FX This work was supported by the Stanley Medical Research Institute
(Bethesda, Maryland) and the U.S. Department of the Army. The views
expressed are those of the authors and should not be construed to
represent the positions of the U.S. Department of the Army or the U.S.
Department of Defense.
NR 50
TC 19
Z9 19
U1 4
U2 4
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD OCT
PY 2011
VL 62
IS 10
BP 1152
EP 1158
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA 827WT
UT WOS:000295461000008
PM 21969641
ER
PT J
AU Wright, KM
Britt, TW
Bliese, PD
Adler, AB
AF Wright, Kathleen M.
Britt, Thomas W.
Bliese, Paul D.
Adler, Amy B.
TI Insomnia Severity, Combat Exposure and Mental Health Outcomes
SO STRESS AND HEALTH
LA English
DT Article
DE insomnia; combat disorders; stress disorders; post-traumatic reactions;
alcohol related disorders
ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; POOR SLEEP
QUALITY; PRIMARY-CARE; SOLDIERS; IRAQ; DEPRIVATION; PERFORMANCE;
ADAPTATION; MORBIDITY
AB Few studies have examined insomnia severity as a moderator of the impact of combat experiences on posttraumatic stress disorder (PTSD) and alcohol problems, such that combat exposure is expected to have more negative consequences for soldiers who report insomnia. In this study, a sample of 522 military personnel completed measures of PTSD and alcohol problems prior to a 12-month deployment to Iraq, and then completed measures assessing insomnia severity, combat exposure, PTSD, alcohol problems and overall distress 3 months post-deployment. Results of a moderated multiple regression indicated that insomnia severity interacted with combat exposure to predict PTSD and alcohol problems after controlling for pre-deployment baseline measures of these outcomes, such that the relationship between combat exposure and the mental health symptoms was stronger when insomnia severity was greater. Results are discussed from the perspective of the role of insomnia in the development of PTSD and alcohol problems, as well as from an occupational health perspective where insomnia may deprive individuals of the resources they need to recover from the effects of severe occupational stressors found in high risk occupations. Published in 2010 by John Wiley & Sons, Ltd.
C1 [Wright, Kathleen M.; Britt, Thomas W.; Adler, Amy B.] Walter Reed Army Inst Res, Heidelberg, Germany.
[Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Wright, KM (reprint author), US Army Med Res Unit Europe, Nachrichten Kaserne Postfach 103180, D-69021 Heidelberg, Germany.
EM kathleen.wright@us.army.mil
NR 59
TC 4
Z9 4
U1 4
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1532-3005
J9 STRESS HEALTH
JI Stress Health
PD OCT
PY 2011
VL 27
IS 4
BP 325
EP 333
DI 10.1002/smi.1373
PG 9
WC Psychology, Applied; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 833IB
UT WOS:000295876000006
ER
PT J
AU Lathrop, SD
Wintermute, S
Laird, JE
AF Lathrop, Scott D.
Wintermute, Samuel
Laird, John E.
TI Exploring the Functional Advantages of Spatial and Visual Cognition From
an Architectural Perspective
SO TOPICS IN COGNITIVE SCIENCE
LA English
DT Article
DE Cognitive architecture; Mental imagery; Spatial cognition; Visual
cognition
ID COMPUTATIONAL MODEL; MENTAL-IMAGERY; INTELLIGENCE; DIAGRAMS
AB We present a general cognitive architecture that tightly integrates symbolic, spatial, and visual representations. A key means to achieving this integration is allowing cognition to move freely between these modes, using mental imagery. The specific components and their integration are motivated by results from psychology, as well as the need for developing a functional and efficient implementation. We discuss functional benefits that result from the combination of multiple content-based representations and the specialized processing units associated with them. Instantiating this theory, we then discuss the architectural components and processes, and illustrate the resulting functional advantages in two spatially and visually rich domains. The theory is then compared to other prominent approaches in the area.
C1 [Lathrop, Scott D.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Wintermute, Samuel; Laird, John E.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA.
RP Lathrop, SD (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM scott.lathrop@usma.edu
NR 45
TC 3
Z9 3
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1756-8757
J9 TOP COGN SCI
JI Top. Cogn. Sci.
PD OCT
PY 2011
VL 3
IS 4
BP 796
EP 818
DI 10.1111/j.1756-8765.2010.01130.x
PG 23
WC Psychology, Experimental
SC Psychology
GA 832VK
UT WOS:000295836800012
PM 25164511
ER
PT J
AU Chason, RJ
Csokmay, J
Segars, JH
DeCherney, AH
Armant, DR
AF Chason, Rebecca J.
Csokmay, John
Segars, James H.
DeCherney, Alan H.
Armant, D. Randall
TI Environmental and epigenetic effects upon preimplantation embryo
metabolism and development
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID ASSISTED REPRODUCTIVE TECHNOLOGY; X-CHROMOSOME INACTIVATION; EARLY MOUSE
EMBRYO; IN-VITRO; DNA METHYLATION; GENE-EXPRESSION; HISTONE
MODIFICATIONS; OXIDATIVE STRESS; IMPRINTED GENES; OXYGEN-TENSION
AB In vitro fertilization has provided a unique window into the metabolic processes that drive embryonic growth and development from a fertilized ovum to a competent blastocyst. Post-fertilization development is dependent upon a dramatic reshuffling of the parental genomes during meiosis, as well as epigenetic changes that provide a new and autonomous set of instructions to guide cellular differentiation both in the embryo and beyond. Although early literature focused simply on the substrates and culture conditions required for progress through embryonic development, more recent insights lead us to suggest that the surrounding environment can alter the epigenome, which can, in turn, impact upon embryonic metabolism and developmental competence.
C1 [Chason, Rebecca J.; Segars, James H.; DeCherney, Alan H.; Armant, D. Randall] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
[Csokmay, John] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Armant, D. Randall] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Detroit, MI 48201 USA.
[Armant, D. Randall] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
[Armant, D. Randall] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA.
RP Armant, DR (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
EM D.Armant@Wayne.edu
OI Armant, D. Randall/0000-0001-5904-9325
FU NIH [HD045966]; Eunice Kennedy Shriver National Institute of Child
Health and Human Development
FX This work was supported in part by the Intramural Research Program of
the NIH, the Eunice Kennedy Shriver National Institute of Child Health
and Human Development, and NIH grant HD045966 (to D.R.A.).
NR 108
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U2 17
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD OCT
PY 2011
VL 22
IS 10
BP 412
EP 420
DI 10.1016/j.tem.2011.05.005
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 835LI
UT WOS:000296037500004
PM 21741268
ER
PT J
AU Melendez, V
Pybus, B
Sousa, J
Li, Q
Caridha, D
Collazo, V
Olmeda, R
Riscoe, M
Kelly, J
AF Melendez, V.
Pybus, B.
Sousa, J.
Li, Q.
Caridha, D.
Collazo, V.
Olmeda, R.
Riscoe, M.
Kelly, J.
TI Metabolism and disposition of novel liver stage-active acridone
antimalarial drugs
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Meeting Abstract
C1 [Melendez, V.; Pybus, B.; Sousa, J.; Li, Q.; Caridha, D.; Collazo, V.; Olmeda, R.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Riscoe, M.; Kelly, J.] Portland VA Med Ctr, Portland, OR USA.
[Riscoe, M.; Kelly, J.] Portland State Univ, Portland, OR 97207 USA.
RI Sousa, Jason/A-9177-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2276
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD OCT
PY 2011
VL 16
SU 1
SI SI
BP 145
EP 146
PG 2
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 828RC
UT WOS:000295519100419
ER
PT J
AU Gasda, SE
Farthing, MW
Kees, CE
Miller, CT
AF Gasda, Sarah E.
Farthing, Matthew W.
Kees, Christopher E.
Miller, Cass T.
TI Adaptive split-operator methods for modeling transport phenomena in
porous medium systems
SO ADVANCES IN WATER RESOURCES
LA English
DT Article
DE Reactive transport; Error estimation; Error control; Algorithms
ID FINITE-ELEMENT METHODS; REACTIVE TRANSPORT; RESERVOIR SIMULATION;
PARABOLIC PROBLEMS; GROUNDWATER-FLOW; TIME INTEGRATION; GALERKIN
METHODS; IMPES STABILITY; A-POSTERIORI; EQUATIONS
AB Split-operator methods are commonly used to approximate environmental models. These methods facilitate the tailoring of different approximation approaches to different portions of the differential operator and provide a means to split large coupled problems into pieces that are more amenable to parallel computation than the original fully-coupled problem. However, split-operator methods introduce an additional source of approximation error into the solution, which is typically either ignored or controlled heuristically. In this work, we develop two methods to estimate and control the error in split-operator methods, which lead to a dynamic adjustment of the temporal splitting step based upon the error estimators. The proposed methods are shown to yield robust solutions that provide the desired control of error. In addition, for a typical nonlinear reaction problem, the new methods are shown to reduce the solution error by more than two orders of magnitude compared to standard methods for an identical level of computational effort. The algorithms introduced and evaluated have widespread applicability in environmental modeling. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Gasda, Sarah E.; Miller, Cass T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Farthing, Matthew W.; Kees, Christopher E.] USA, Engineer Res & Dev Stn, Vicksburg, MS 39180 USA.
RP Miller, CT (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
EM sgasda@unc.edu; matthew.w.farthing@usace.army.mil;
christopher.e.kees@usace.army.mil; casey_miller@unc.edu
RI Miller, Cass T./I-6613-2012
OI Miller, Cass T./0000-0001-6082-9273
FU US Army Corps of Engineers; Coastal and Hydraulics Laboratory;
Department of Energy [DE-SC0002163]; National Science Foundation
[ATM-0941235]
FX The work of MWF and CEK was supported by the Civil Works and Military
Engineering 6.1 research programs of the US Army Corps of Engineers and
the Coastal and Hydraulics Laboratory Internal Research Investment
Program. Permission was granted by the Chief of Engineers to publish
this information. The work of CTM was supported by Department of Energy
Grant DE-SC0002163 and National Science Foundation Grant ATM-0941235.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0309-1708
EI 1872-9657
J9 ADV WATER RESOUR
JI Adv. Water Resour.
PD OCT
PY 2011
VL 34
IS 10
BP 1268
EP 1282
DI 10.1016/j.advwatres.2011.06.004
PG 15
WC Water Resources
SC Water Resources
GA 831BB
UT WOS:000295702600007
ER
PT J
AU Xu, D
Ryan, KL
Rickards, CA
Zhang, GQ
Convertino, VA
Mukkamala, R
AF Xu, Da
Ryan, Kathy L.
Rickards, Caroline A.
Zhang, Guanqun
Convertino, Victor A.
Mukkamala, Ramakrishna
TI Improved pulse transit time estimation by system identification analysis
of proximal and distal arterial waveforms
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE arterial blood pressure; arterial stiffness; foot-to-foot detection;
impulse response; pulse wave velocity
ID HYPERTENSIVE PATIENTS; VELOCITY; PRESSURE; IMPEDANCE; STIFFNESS
AB Xu D, Ryan KL, Rickards CA, Zhang G, Convertino VA, Mukkamala R. Improved pulse transit time estimation by system identification analysis of proximal and distal arterial waveforms. Am J Physiol Heart Circ Physiol 301: H1389-H1395, 2011. First published July 29, 2011; doi: 10.1152/ajpheart.00443.2011.-We investigated the system identification approach for potentially improved estimation of pulse transit time (PTT), a popular arterial stiffness marker. In this approach, proximal and distal arterial waveforms are measured and respectively regarded as the input and output of a system. Next, the system impulse response is identified from all samples of the measured input and output. Finally, the time delay of the impulse response is detected as the PTT estimate. Unlike conventional foot-to-foot detection techniques, this approach is designed to provide an artifact robust estimate of the true PTT in the absence of wave reflection. The approach is also applicable to arbitrary types of arterial waveforms. We specifically applied a parametric system identification technique to noninvasive impedance cardiography (ICG) and peripheral arterial blood pressure waveforms from 15 humans subjected to lower-body negative pressure. We assessed the technique through the correlation coefficient (r) between its 1/PTT estimates and measured diastolic pressure (DP) per subject and the root mean squared error (RMSE) of the DP predicted from these estimates and measured DP. The technique achieved average r and RMSE values of 0.81 +/- 0.16 and 4.3 +/- 1.3 mmHg. For comparison, the corresponding values were 0.59 +/- 0.37 (P < 0.05) and 5.9 +/- 2.5 (P < 0.01) mmHg for the conventional technique applied to the same waveforms and 0.28 +/- 0.40 (P < 0.001) and 7.2 +/- 1.8 (P < 0.001) mmHg for the conventional technique with the ECG waveform substituted for the ICG waveform. These results demonstrate, perhaps for the first time, that the system identification approach can indeed improve PTT estimation.
C1 [Mukkamala, Ramakrishna] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA.
[Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA.
RP Mukkamala, R (reprint author), Michigan State Univ, Dept Elect & Comp Engn, 2120 Engn Bldg, E Lansing, MI 48824 USA.
EM rama@egr.msu.edu
RI Xu, Da/A-6423-2012
FU National Science Foundation [0643477]; Telemedicine and Advanced
Technology Research Center at the U.S. Army Medical Research and
Materiel Command [W81XWH-10-2-0124]
FX This work was supported by National Science Foundation CAREER Grant
0643477 and by the Telemedicine and Advanced Technology Research Center
at the U.S. Army Medical Research and Materiel Command through Award
W81XWH-10-2-0124.
NR 23
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U1 1
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2011
VL 301
IS 4
BP H1389
EP H1395
DI 10.1152/ajpheart.00443.2011
PG 7
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Physiology
GA 826NE
UT WOS:000295360100020
PM 21803948
ER
PT J
AU Preston, C
Almashat, S
Peik, S
Desale, M
Alexander, M
AF Preston, Charles
Almashat, Sammy
Peik, Samuel
Desale, Meghana
Alexander, Miriam
TI Role of Preventive Medicine Residencies in Medical Education A National
Survey
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID PUBLIC-HEALTH; POPULATION HEALTH; DEPARTMENTS; PERSPECTIVE
AB Background: In an era of substantial reform to the nation's health system, there has never been a greater need for physicians to understand public health. One way to foster public health in medical education is to utilize the resources within General Preventive Medicine and Public Health (PM) residency programs. Trained in public health and clinical medicine, PM physicians are uniquely positioned to bridge these disciplines.
Purpose: Little is known about the level of engagement of PM residency programs in medical education. This study explores the current state of their involvement.
Methods: Program directors from all Accreditation Council for Graduate Medical Educationaccredited PM residency programs were asked to participate in a survey to assess involvement in medical student and non-PM resident education, including on nine key engagement criteria covering teaching, rotations, career interest groups, and other activities. The study was conducted and data analyzed in 2010.
Results: Thirty-five of 38 (92%) programs responded. Seventy-four percent reported that PM faculty taught medical students, and 34% taught at non-PM residency programs. The lowest level of engagement was seen in PM residents teaching non-PM residents (12%). Over half of all programs met four or fewer of the nine criteria. The most common barriers to engagement were lack of funding (53%) and lack of time (50%).
Conclusions: These results suggest that PM residency programs are an underutilized resource in fostering public health in medical education, especially on engagement at the level of graduate medical education. Strategies to improve engagement should consider the nine criteria outlined in this study, as well as common barriers. (Am J Prev Med 2011;41(4S3):S290-S295) (C) 2011 American Journal of Preventive Medicine
C1 [Preston, Charles; Almashat, Sammy; Alexander, Miriam] Johns Hopkins Bloomberg Sch Publ Hlth, Gen Prevent Med Program, Baltimore, MD USA.
[Desale, Meghana] Johns Hopkins Sch Med, Baltimore, MD USA.
[Peik, Samuel] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA.
RP Preston, C (reprint author), 615 N Wolfe St,RM WB 602, Baltimore, MD 21205 USA.
EM cpreston@jhsph.edu
RI Peik, Samuel/B-7867-2011
FU CDC-AAMC (Association of American Medical Colleges) [5U36CD319276]
FX Publication of this article was supported by the CDC-AAMC (Association
of American Medical Colleges) Cooperative Agreement number 5U36CD319276.
NR 13
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U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD OCT
PY 2011
VL 41
IS 4
SU 3
BP S290
EP S295
DI 10.1016/j.amepre.2011.06.021
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 832SK
UT WOS:000295827300025
PM 21961678
ER
PT J
AU Robison, HW
George, SG
Slack, WT
McAllister, CT
AF Robison, Henry W.
George, Steven G.
Slack, William T.
McAllister, Chris T.
TI First Record of the Silver Lamprey, Ichthyomyzon unicuspis
(Petromyzontiformes: Petromyzontidae), from Arkansas
SO AMERICAN MIDLAND NATURALIST
LA English
DT Article
AB We report the Silver Lamprey (Ichthyomyzon unicupis) from Arkansas for the first time. Fifteen adult I. unicuspis attached to paddlefish (Polyodon spathula) were collected in Apr. 2005 from the White River near the confluence of the Black River, Independence and Jackson counties. Twelve (80%) of the I. unicuspis possessed 3 teeth (including the apex) in the anterior row, while the other 3 had 4 teeth in their anterior row; unicuspid teeth arrangement in the lateral row were 3 + 3 for 11 (73%) lampreys while 4 had 4 + 4 teeth in the lateral. row. Two additional specimens collected in Apr. 1972 and May 1998 from the Buffalo and White rivers in Marion and Prairie counties, respectively, and originally identified as Chestnut Lampreys (Ichthyomyzon castaneus), were re-examined and identified as I. unicuspis. The addition of I unicuspis to the lamprey fauna of Arkansas brings to five the number of species currently occurring in the state.
C1 [Robison, Henry W.] So Arkansas Univ, Dept Biol, Magnolia, AR 71754 USA.
[George, Steven G.; Slack, William T.] USA, Corps Engineers Res & Dev Ctr, Waterways Expt Stn EE A, Vicksburg, MS 39180 USA.
[McAllister, Chris T.] Eastern Oklahoma State Coll, Div Sci & Math, Idabel, OK 74745 USA.
RP Robison, HW (reprint author), So Arkansas Univ, Dept Biol, Magnolia, AR 71754 USA.
FU Memphis District, USACE
FX Sincere appreciation is expressed to Dr. Neil H. Douglas, Curator of the
Museum of Natural History of the University of Louisiana at Monroe
(NLU), for allowing complete access to the NLU Collection of Fishes to
examine lamprey specimens. We also thank Matt Roberts (MMNS Ichthyology
Curator) for providing access to specimens and to Bernard Kuhajda
(Collections Manager, University of Alabama Ichthyology Collection) for
confirming the identification of lamprey specimens sent to him earlier.
HWR thanks Nick Lang for apprising him of the existence of the Silver
Lamprey specimen initially. Special thanks are extended to Jan Hoover,
Bill Lancaster, Bradley Lewis and jay Collins, USACE-ERDC, who collected
the original lamprey specimens. Funding for USACE-ERDC was provided by
the Memphis District, USACE for fish surveys conducted on the White
River. Permission to publish was provided by the Chief of Engineers.
NR 13
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U1 0
U2 3
PU AMER MIDLAND NATURALIST
PI NOTRE DAME
PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA
SN 0003-0031
J9 AM MIDL NAT
JI Am. Midl. Nat.
PD OCT
PY 2011
VL 166
IS 2
BP 458
EP 461
PG 4
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 830FC
UT WOS:000295641900020
ER
PT J
AU Shafer, DJ
Kaldy, JE
Sherman, TD
Marko, KM
AF Shafer, Deborah J.
Kaldy, James E.
Sherman, Timothy D.
Marko, Katharine M.
TI Effects of salinity on photosynthesis and respiration of the seagrass
Zostera japonica: A comparison of two established populations in North
America
SO AQUATIC BOTANY
LA English
DT Article
DE Zostera japonica; Introduced species; Non-native species;
Photosynthesis; Salinity
ID HALOPHILA-OVALIS; NOLTII HORNEM; THALASSIA-TESTUDINUM; INTRODUCED
SEAGRASS; HALODULE-WRIGHTII; RESPONSE CURVES; WILLAPA BAY; IN-SITU;
MARINA; GROWTH
AB Photosynthetic responses were quantified for two Zostera japonica Aschers. and Graebn. populations from the northern and southern limits of distribution exposed to a range of salinities along the Pacific Coast of North America. Plants were collected from Padilla Bay, Washington (northern) and Coos Bay, Oregon, USA (southern) and cultured together in experimental tanks at 3 salinities (5, 20 and 35) under saturating irradiance for 3 weeks. Subsequently, photosynthesis-irradiance (P vs. E curves) relationships for leaf segments from the two populations were assessed using an oxygen electrode system. We found no evidence for diet rhythms in either light saturated photosynthesis (Pm) or dark respiration (R(d)). For the Padilla Bay population, P(max) ranged from 192 to 390 mu mol O(2) g DW(-1) h(-1); for the Coos Bay population P(max) ranged from 226 to 774 mu mol O(2) g DW(-1) h(-1). Photosynthetic maxima of the Coos Bay plants occurred at a salinity of 20, whereas salinity had no effect on the photosynthetic maxima of the Padilla Bay plants. There were significant differences in leaf tissue R(d) among salinity treatments but the two populations responded similarly to salinity. North American populations of Z.japonica are best adapted to intermediate salinities, displaying minimum R(d) rates, lower compensation irradiance, higher saturation irradiance, and greater Pmax rates at a salinity of 20. Additionally, the southern population may be better adapted to southward expansion along the Pacific Coast and changes associated with global climate change. Published by Elsevier B.V.
C1 [Kaldy, James E.; Marko, Katharine M.] US EPA, Western Ecol Div, Newport, OR 97365 USA.
[Shafer, Deborah J.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Sherman, Timothy D.] Univ S Alabama, Dept Biol, Mobile, AL 36688 USA.
RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA.
EM kaldy.jim@epa.gov
NR 50
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U1 2
U2 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3770
J9 AQUAT BOT
JI Aquat. Bot.
PD OCT
PY 2011
VL 95
IS 3
BP 214
EP 220
DI 10.1016/j.aquabot.2011.06.003
PG 7
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA 831VL
UT WOS:000295759100007
ER
PT J
AU Campbell, GL
Hills, SL
Fischer, M
Jacobson, JA
Hoke, CH
Hombach, JM
Marfin, AA
Solomon, T
Tsai, TF
Tsu, VD
Ginsburg, AS
AF Campbell, Grant L.
Hills, Susan L.
Fischer, Marc
Jacobson, Julie A.
Hoke, Charles H.
Hombach, Joachim M.
Marfin, Anthony A.
Solomon, Tom
Tsai, Theodore F.
Tsu, Vivien D.
Ginsburg, Amy S.
TI Estimated global incidence of Japanese encephalitis: a systematic review
SO BULLETIN OF THE WORLD HEALTH ORGANIZATION
LA English
DT Review
ID CLINICAL-FEATURES; CHILDREN YOUNGER; SURVEILLANCE; DISEASE; BURDEN;
CHINA; IMMUNIZATION; AUSTRALIA; INDONESIA; SHANGHAI
AB Objective To update the estimated global incidence of Japanese encephalitis (JE) using recent data for the purpose of guiding prevention and control efforts.
Methods Thirty-two areas endemic for JE in 24 Asian and Western Pacific countries were sorted into 10 incidence groups on the basis of published data and expert opinion. Population-based surveillance studies using laboratory-confirmed cases were sought for each incidence group by a computerized search of the scientific literature. When no eligible studies existed for a particular incidence group, incidence data were extrapolated from related groups.
Findings A total of 12 eligible studies representing 7 of 10 incidence groups in 24 JE-endemic countries were identified. Approximately 67 900 JE cases typically occur annually (overall incidence: 1.8 per 100 000), of which only about 10% are reported to the World Health Organization. Approximately 33 900 (50%) of these cases occur in China (excluding Taiwan) and approximately 51 000 (75%) occur in children aged 0-14 years (incidence: 5.4 per 100 000). Approximately 55 000 (81%) cases occur in areas with well established or developing JE vaccination programmes, while approximately 12 900 (19%) occur in areas with minimal or no JE vaccination programmes.
Conclusion Recent data allowed us to refine the estimate of the global incidence of JE, which remains substantial despite improvements in vaccination coverage. More and better incidence studies in selected countries, particularly China and India, are needed to further refine these estimates.
C1 [Tsu, Vivien D.; Ginsburg, Amy S.] PATH, Seattle, WA USA.
[Campbell, Grant L.] Ross River Consulting, La Porte, IN USA.
[Hills, Susan L.; Fischer, Marc] Ctr Dis Control & Prevent, Ft Collins, CO USA.
[Jacobson, Julie A.] Bill & Melinda Gates Fdn, Seattle, WA USA.
[Hoke, Charles H.] US Army Med Mat Dev Act, Pharmaceut Syst Project Management Off, Ft Detrick, MD USA.
[Hombach, Joachim M.] World Hlth Org, Initiat Vaccine Res, Geneva, Switzerland.
[Marfin, Anthony A.] Washington State Dept Hlth, Shoreline, WA USA.
[Solomon, Tom] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England.
[Tsai, Theodore F.] Novartis Vaccines, Sci Affairs, Cambridge, MA USA.
RP Ginsburg, AS (reprint author), PATH, POB 900922, Seattle, WA USA.
EM AGinsburg@path.org
OI Solomon, Tom/0000-0001-7266-6547
FU Program for Appropriate Technology in Health (PATH)
FX This study was funded by the Program for Appropriate Technology in
Health (PATH).
NR 45
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U1 0
U2 11
PU WORLD HEALTH ORGANIZATION
PI GENEVA 27
PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND
SN 0042-9686
J9 B WORLD HEALTH ORGAN
JI Bull. World Health Organ.
PD OCT
PY 2011
VL 89
IS 10
BP 766
EP 774
DI 10.2471/BLT.10.085233
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 831DA
UT WOS:000295707700015
PM 22084515
ER
PT J
AU Ioannou, A
Lucca, JD
Tsokos, GC
AF Ioannou, Antonis
Lucca, Jurandir Dalle
Tsokos, George C.
TI Immunopathogenesis of ischemia/reperfusion-associated tissue damage
SO CLINICAL IMMUNOLOGY
LA English
DT Review
DE Ischemia/reperfusion injury; Tissue damage; Complement; T cells; B cells
ID ISCHEMIA-REPERFUSION INJURY; ACUTE-RENAL-FAILURE;
SYSTEMIC-LUPUS-ERYTHEMATOSUS; C-REACTIVE PROTEIN; ALTERNATIVE COMPLEMENT
PATHWAY; MEMBRANE ATTACK COMPLEX; CD4(+) T-LYMPHOCYTES; REMOTE ORGAN
INJURY; INTESTINAL ISCHEMIA; MESENTERIC ISCHEMIA/REPERFUSION
AB Ischemia/reperfusion (IR) instigates a complex array of inflammatory events which result in damage to the local tissue. IR-related organ damage occurs invariably in several clinical conditions including trauma, organ transplantation, autoimmune diseases and revascularization procedures. We critically review available pre-clinical experimental information on the role of immune response in the expression of tissue damage following IR. Distinct elements of the innate and adaptive immune response are involved in the expression of tissue injury. Interventions such as prevention of binding of natural antibody to antigen expressed on the surface of ischemia-conditioned cells, inhibition of the ensuing complement activation, modulation of Toll-like receptors, B or T cell depletion and blockade of inflammatory cytokines and chemokines limit IR injury in preclinical studies. Clinical trials that will determine the therapeutic value of each approach is needed. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Ioannou, Antonis; Tsokos, George C.] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
[Lucca, Jurandir Dalle] USA, Inst Surg Res, San Antonio, TX USA.
RP Ioannou, A (reprint author), Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
EM aioannou@bidmc.harvard.edu; gtsokos@bidmc.harvard.edu
FU Medical Research and Materiel Command [W81XWH/09/1/0530]
FX work was supported by W81XWH/09/1/0530 from the Medical Research and
Materiel Command.
NR 139
TC 38
Z9 39
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1521-6616
J9 CLIN IMMUNOL
JI Clin. Immunol.
PD OCT
PY 2011
VL 141
IS 1
BP 3
EP 14
DI 10.1016/j.clim.2011.07.001
PG 12
WC Immunology
SC Immunology
GA 829EC
UT WOS:000295558500002
PM 21839685
ER
PT J
AU Miyazaki, M
Isoda, H
AF Miyazaki, Mitsue
Isoda, Hiroyoshi
TI Non-contrast-enhanced MR angiography of the abdomen
SO EUROPEAN JOURNAL OF RADIOLOGY
LA English
DT Article
DE Magnetic resonance angiography (MRA); CT; Arterial spin labeling (ASL);
Flow-dependent MRA; Flow-independent MRA
ID STATE FREE-PRECESSION; FAST SPIN-ECHO; MAGNETIC-RESONANCE ANGIOGRAPHY;
SELECTIVE INVERSION-RECOVERY; SINGLE BREATH-HOLD; NEPHROGENIC SYSTEMIC
FIBROSIS; VENOUS FLOW DISTRIBUTION; HALF-FOURIER FSE; RENAL-ARTERIES;
TAGGING PULSE
AB Non-contrast-enhanced magnetic resonance angiography (MRA) techniques have experienced a resurgence of interest in the MR community, in part because of safety concerns related to the possible link between gadolinium-based contrast agents and nephrogenic systemic fibrosis (NSF). In abdominal MRA, NSF is of particular concern, given that many of the patients may have renal disease. After introducing various non-contrast-enhanced MRA techniques, this article focuses on MRA applications in the abdomen, specifically the renal arteries and portal and hepatic veins. Developments on the horizon are discussed, including techniques that provide standardization of renal artery imaging, challenges in imaging of the hepatic arteries, and further advancement at 3T. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Miyazaki, Mitsue; Isoda, Hiroyoshi] USA, MRI, Toshiba Med Res Inst, Vernon Hills, IL 60061 USA.
[Isoda, Hiroyoshi] Kyoto Univ, Dept Diagnost Imaging & Nucl Med, Kyoto, Japan.
RP Miyazaki, M (reprint author), USA, MRI, Toshiba Med Res Inst, 706N Deerpath Dr, Vernon Hills, IL 60061 USA.
EM mmiyazaki@tmriusa.com
NR 66
TC 22
Z9 28
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0720-048X
J9 EUR J RADIOL
JI Eur. J. Radiol.
PD OCT
PY 2011
VL 80
IS 1
BP 9
EP 23
DI 10.1016/j.ejrad.2011.01.093
PG 15
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 828XP
UT WOS:000295538200003
PM 21330081
ER
PT J
AU Maseng, T
Landry, R
Young, K
AF Maseng, Torleiv
Landry, Randall
Young, Kenneth
TI MILITARY COMMUNICATIONS
SO IEEE COMMUNICATIONS MAGAZINE
LA English
DT Editorial Material
C1 [Maseng, Torleiv] SINTEF, N-7034 Trondheim, Norway.
[Maseng, Torleiv] NC3A NATO Res Ctr, The Hague, Netherlands.
[Maseng, Torleiv] Lund Univ, S-22100 Lund, Sweden.
[Maseng, Torleiv] Univ Oslo, N-0316 Oslo, Norway.
[Landry, Randall] Univ Vermont, Burlington, VT 05405 USA.
[Young, Kenneth] Telcordia Technol, Govt Project Dev, Appl Res Org, Piscataway, NJ USA.
[Young, Kenneth] Networks Collaborat Technol Alliance, Alliance, OH USA.
[Young, Kenneth] USA, CERDECs, Washington, DC USA.
EM torleiv.maseng@ffi.no; rlandry@mitre.org
NR 0
TC 0
Z9 0
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0163-6804
J9 IEEE COMMUN MAG
JI IEEE Commun. Mag.
PD OCT
PY 2011
VL 49
IS 10
BP 52
EP 52
PG 1
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 831LA
UT WOS:000295731000004
ER
PT J
AU Farmer, TJ
Darwish, A
Huebschman, B
Viveiros, E
Hung, HA
Zaghloul, ME
AF Farmer, Thomas J.
Darwish, Ali
Huebschman, Benjamin
Viveiros, Edward
Hung, H. Alfred
Zaghloul, Mona E.
TI Millimeter-Wave SiGe HBT High Voltage/High Power Architecture
Implementation
SO IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS
LA English
DT Article
DE Heterojunction bipolar transistor (HBT); millimeter-wave; power
amplifiers (PAs); SiGe; silicon; silicon alloys
ID CMOS
AB This letter discusses the first implementation of the high voltage/high power (HiVP) architecture in silicon at millimeter-wave frequencies. Implemented in a commercial 0.12 mu m SiGe HBT BiCMOS process, P(SAT) = 19.0 dBm with a PAE of 11.47% in an area of 0.21 mm(2), have been measured at center frequency 30 GHz. This architecture provides a new tool for silicon designers to achieve high output power, customizable bias, and a way to minimize, if not eliminate, matching circuitry at millimeter-wave frequencies. Simulation, layout, fabrication, and measurement results are presented in this letter.
C1 [Farmer, Thomas J.; Huebschman, Benjamin] USA, Res Lab, Elect Technol Branch, Adelphi, MD 20783 USA.
[Darwish, Ali] Amer Univ Cairo, USA, Res Lab, Dept Elect Engn, New Cairo, Egypt.
[Zaghloul, Mona E.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA.
RP Farmer, TJ (reprint author), USA, Res Lab, Elect Technol Branch, Adelphi, MD 20783 USA.
EM thomas.farmer2@us.army.mil; adarwish@aucegypt.edu;
benjamin.huebschman@us.army.mil; edward.viveiros@us.army.mil;
h.alfred.hung@us.army.mil; zaghloul@gwu.edu
FU George Washington University; U.S. Army Research Lab; Achievement
Rewards for College Scientists
FX This work was supported by The George Washington University, The U.S.
Army Research Lab, and the Achievement Rewards for College Scientists.
NR 6
TC 3
Z9 4
U1 1
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1531-1309
J9 IEEE MICROW WIREL CO
JI IEEE Microw. Wirel. Compon. Lett.
PD OCT
PY 2011
VL 21
IS 10
BP 544
EP 546
DI 10.1109/LMWC.2011.2164782
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA 830VZ
UT WOS:000295687200012
ER
PT J
AU Kaushal, P
Brown, DJ
Lander, L
Brietzke, S
Shah, RK
AF Kaushal, Pankaj
Brown, David J.
Lander, Lina
Brietzke, Scott
Shah, Rahul K.
TI Aspirated foreign bodies in pediatric patients, 1968-2010: A comparison
between the United States and other countries
SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
LA English
DT Article
DE Choking; Small parts cylinder; Bronchoscopy; Esophagoscopy
ID CHILDREN; PREVENTION; MANAGEMENT; RISK
AB Objectives: To identify the most commonly aspirated airway foreign bodies (FBs) and identify opportunities for intervention.
Methods: Literature was searched and pertinent articles from 1968 to 2010 (n = 58; 14 articles were from the United States and 41 international) were reviewed. A list of the most commonly retrieved FBs resulted from the analysis.
Results: 11,880 FBs were analyzed (1934 from the US and 9946 international, p < 0.0001). Food (edible) and food-related (inedible, e.g. bones) FBs were associated with most cases (68% in US and 84% internationally, p < 0.0001). In this category, most common in the US were: nuts (41%, 44% of which were peanuts), seeds (8%, 19% of which were sunflower seeds), vegetables (5%, 41.7% of which were carrots), popcorn (4%), and bones (2%). Internationally: nuts (37%, 76.9% of which were peanuts), seeds (29%, 32.7% of which were watermelon seeds), beans (7.8%), and bones (2%). Non-food sources were the source of FBs in 25% of US patients and 12% internationally (p < 0.0001). Of non-food sources, the most common FBs in US were: metallic (8%) and plastic (7%). Internationally: metallic (5%) and plastic (2%).
Conclusions: Most FB aspirations in pediatric patients occur while eating, with peanuts posing the greatest risk. The majority of FBs worldwide are nuts, seeds, and metallic objects. The significantly higher proportion of non-food FBs in the US may suggest that tighter regulation of products is needed. Educational or more stringent regulatory interventions should be considered to reduce FB aspirations from the sources highlighted herein. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Shah, Rahul K.] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Div Pediat Otolaryngol, Washington, DC 20052 USA.
[Brown, David J.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Wauwatosa, WI USA.
[Lander, Lina] Univ Nebraska Med Ctr, Dept Epidemiol, Omaha, NE USA.
[Brietzke, Scott] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Shah, RK (reprint author), Childrens Natl Med Ctr, Div Otolaryngol, 111 Michigan Ave NW, Washington, DC 20100 USA.
EM rshah@cnmc.org
NR 11
TC 5
Z9 5
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-5876
J9 INT J PEDIATR OTORHI
JI Int. J. Pediatr. Otorhinolaryngol.
PD OCT
PY 2011
VL 75
IS 10
BP 1322
EP 1326
DI 10.1016/j.ijporl.2011.07.027
PG 5
WC Otorhinolaryngology; Pediatrics
SC Otorhinolaryngology; Pediatrics
GA 827LX
UT WOS:000295431100022
PM 21840609
ER
PT J
AU Hospenthal, DR
Chung, KK
Lairet, K
Thompson, EH
Guarro, J
Renz, EM
Sutton, DA
AF Hospenthal, Duane R.
Chung, Kevin K.
Lairet, Kimberly
Thompson, Elizabeth H.
Guarro, Josep
Renz, Evan M.
Sutton, Deanna A.
TI Saksenaea erythrospora Infection following Combat Trauma
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID VASIFORMIS; ZYGOMYCOSIS
AB Saksenaea erythrospora is a newly described species of the order Mucorales which has not previously been reported as a cause of human infection. We report a fatal case of S. erythrospora invasive burn wound infection in a 26-year-old male injured during combat operations in Iraq.
C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, MCHE MDI, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.; Lairet, Kimberly; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Thompson, Elizabeth H.; Sutton, Deanna A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, Fungus Testing Lab, San Antonio, TX 78229 USA.
[Guarro, Josep] Univ Rovira & Virgili, Sch Med, Mycol Unit, E-43201 Reus, Spain.
[Guarro, Josep] Univ Rovira & Virgili, IISPV, E-43201 Reus, Spain.
RP Hospenthal, DR (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
OI Guarro, Josep/0000-0002-7839-7568
NR 11
TC 14
Z9 14
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2011
VL 49
IS 10
BP 3707
EP 3709
DI 10.1128/JCM.05095-11
PG 3
WC Microbiology
SC Microbiology
GA 826NK
UT WOS:000295360700053
PM 21865421
ER
PT J
AU Calvano, TP
Blatz, PJ
Vento, TJ
Wickes, BL
Sutton, DA
Thompson, EH
White, CE
Renz, EM
Hospenthal, DR
AF Calvano, Tatjana P.
Blatz, Peter J.
Vento, Todd J.
Wickes, Brian L.
Sutton, Deanna A.
Thompson, Elizabeth H.
White, Christopher E.
Renz, Evan M.
Hospenthal, Duane R.
TI Pythium aphanidermatum Infection following Combat Trauma
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID HUMAN PYTHIOSIS; INSIDIOSUM; IDENTIFICATION; THAILAND; PATHOGEN
AB Pythium aphanidermatum is a fungus-like plant pathogen which has never been reported as a cause of human infection. We report a case of P. aphanidermatum invasive wound infection in a 21-year-old male injured during combat operations in Afghanistan.
C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA.
[White, Christopher E.; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.
[Sutton, Deanna A.; Thompson, Elizabeth H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, Fungus Testing Lab, San Antonio, TX 78229 USA.
[Blatz, Peter J.] Keesler Med Ctr, Dept Med, Keesler AFB, MS USA.
RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
FU U.S. Army Medical Research and Materiel Command, Office of
Congressionally Directed Medical Research Programs [PR054228]
FX B.L.W. is supported by grant PR054228 from the U.S. Army Medical
Research and Materiel Command, Office of Congressionally Directed
Medical Research Programs.
NR 18
TC 12
Z9 13
U1 2
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2011
VL 49
IS 10
BP 3710
EP 3713
DI 10.1128/JCM.01209-11
PG 4
WC Microbiology
SC Microbiology
GA 826NK
UT WOS:000295360700054
PM 21813724
ER
PT J
AU Ostashev, VE
Wilson, DK
Vecherin, SN
AF Ostashev, Vladimir E.
Wilson, D. Keith
Vecherin, Sergey N.
TI Effect of randomly varying impedance on the interference of the direct
and ground-reflected waves
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SOUND-PROPAGATION; MODELS; MEDIA
AB A randomly varying ground impedance is introduced into the solution for the sound field produced by a point source in a homogeneous atmosphere above a flat ground. The results show that in general the ground with a random impedance cannot be represented by an effective, non-random impedance. The behavior of the solution is studied with a relaxation model for the impedance in which porosity and the static flow resistivity are random variables. Mean values and standard deviations are adopted from measurements of two types of ground surfaces. For both surfaces, the mean intensity of the sound field above a random-impedance ground deviates only slightly from the intensity above a non-random impedance. The normalized standard deviation of intensity fluctuations can, however, be greater than one, thus indicating that for a particular realization of the random impedance, the sound intensity might significantly deviate from the intensity for a non-random impedance. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3624817]
C1 [Ostashev, Vladimir E.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80305 USA.
[Ostashev, Vladimir E.] NOAA Earth Syst Res Lab, Boulder, CO 80305 USA.
[Wilson, D. Keith; Vecherin, Sergey N.] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
RP Ostashev, VE (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, 325 Broadway, Boulder, CO 80305 USA.
EM vladimir.ostashev@noaa.gov
RI Wilson, D. Keith/A-4687-2012
OI Wilson, D. Keith/0000-0002-8020-6871
NR 13
TC 2
Z9 2
U1 0
U2 2
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD OCT
PY 2011
VL 130
IS 4
BP 1844
EP 1850
DI 10.1121/1.3624817
PN 1
PG 7
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 832IY
UT WOS:000295799400032
PM 21973338
ER
PT J
AU Resnik, L
Reiber, G
Evans, R
Steager, P
Barnabe, K
AF Resnik, Linda
Reiber, Gayle
Evans, Rachel
Steager, Pam
Barnabe, Kate
TI New Guidebook to Facilitate VA/DoD Collaboration in Health Care Research
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Resnik, Linda; Steager, Pam; Barnabe, Kate] Providence VA Med Ctr, Providence, RI 02908 USA.
[Resnik, Linda] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA.
[Reiber, Gayle] US Dept Vet Affairs, VA Puget Sound Healthcare Syst, Washington, DC 20420 USA.
[Reiber, Gayle] Univ Washington, Seattle, WA 98195 USA.
[Evans, Rachel] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Resnik, L (reprint author), Providence VA Med Ctr, 830 Chalkstone Ave, Providence, RI 02908 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1085
EP 1087
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300001
PM 22128638
ER
PT J
AU Mancuso, JD
Keep, LW
AF Mancuso, James D.
Keep, Lisa W.
TI Deployment-Related Testing and Treatment for Latent Tuberculosis
Infection, Part II
SO MILITARY MEDICINE
LA English
DT Article
ID GAMMA RELEASE ASSAYS; MYCOBACTERIUM-TUBERCULOSIS; UNITED-STATES;
SKIN-TEST; ACTIVE TUBERCULOSIS; T-CELLS; US-ARMY; RISK; DIAGNOSIS;
CHILDREN
AB Current Topics in Military Tropical Medicine is a Continuing Medical Education series, which updates military medical personnel on questions related to clinical practice while deployed. This issue is Part II of a two-part series on the approach to decision to test, testing and management of latent tuberculosis infection. A representative case is explored in both parts to highlight how to approach service members and their units with regard to latent tuberculosis infection screening and intervention.
C1 [Mancuso, James D.; Keep, Lisa W.] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA.
RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
FU Accreditation Council for Continuing Medical Education
FX As a sponsor accredited by the Accreditation Council for Continuing
Medical Education, it is the policy of Navy Medicine Manpower Personnel,
Training, and Education Command (NM MPT&E) to require the disclosure of
the existence of any significant financial interest or any other
relationships a faculty member or a sponsor has with the manufacturer(s)
or any commercial product(s) discussed in an educational presentation,
and also to disclose discussions of unlabeled/unapproved uses of drugs
or devices during their presentation(s). NM MPT&E Command has
established policies in place that will identify and resolve all
conflicts of interest before this educational activity. Detailed
disclosure is available from the Series Editor. In this issue, the
authors reported that they had no disclosures.
NR 51
TC 3
Z9 3
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1088
EP 1092
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300002
PM 22128639
ER
PT J
AU Velasco, JMS
Yoon, IK
Mason, CJ
Jarman, RG
Bodhidatta, L
Klungthong, C
Silapong, S
Valderama, MTG
Wongstitwilairoong, T
Torres, AG
De Cecchis, DP
Pavlin, JA
AF Velasco, John Mark S.
Yoon, In-Kyu
Mason, Carl J.
Jarman, Richard G.
Bodhidatta, Ladaporn
Klungthong, Chonticha
Silapong, Sasikorn
Valderama, Maria Theresa G.
Wongstitwilairoong, Tippa
Torres, Arturo G.
De Cecchis, Daniel P.
Pavlin, Julie A.
TI Applications of PCR (Real-Time and Mass Tag) and Enzyme-Linked
Immunosorbent Assay in Diagnosis of Respiratory Infections and Diarrheal
Illness Among Deployed US Military Personnel During Exercise Balikatan
2009, Philippines
SO MILITARY MEDICINE
LA English
DT Article
ID ENTEROTOXIGENIC ESCHERICHIA-COLI; POLYMERASE-CHAIN-REACTION;
VIBRIO-CHOLERAE; DISEASE; OPERATIONS
AB Laboratory-based surveillance for diarrheal and respiratory illness was conducted at the 2009 Republic of the Philippines United States Balikatan exercise to determine the presence of specific pathogens endemic in the locations where the military exercises were conducted. Ten stool and 6 respiratory specimens were obtained from individuals meeting case definitions for diarrhea or respiratory illness. Stool specimens were frozen in dry ice and remotely tested using enzyme-linked immunosorbent assay for Rotavirus, Astrovirus, Adenovirus, Entamoeba histolytica, Giardia, and Cryptosporidium and polymerase chain reaction for enterotoxigenic Escherichia coli, Campylobacter, Shigella, Vibrio, Salmonella, and Norovirus. Eight (4 for Campylobacter jejuni, 2 for Campylobacter coli, 1 for Norovirus genogroup II, and 1 for both Campylobacter coli and enterotoxigenic Escherichia coli) of 10 samples were positive for at least 1 enteric pathogen. MassTag polymerase chain reaction for influenza A and B, respiratory syncytial virus groups A and B, human coronavirus-229E and human coronavirus-OC43, human metapneumovirus, enterovirus, human parainfluenza viruses 2,3, and 4a, human adenovirus. Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Legionella pneumonia, and Mycoplasma pneumonia was done on respiratory specimens. Out of 6 samples, 3 tested positive for H. influenzae; 1 tested positive for both H. influenzae and human parainfluenza virus 3; and 2 tested negative. Laboratory-based surveillance can be useful in determining etiologies of diarrheal and respiratory illness of deployed military personnel.
C1 [Velasco, John Mark S.; Yoon, In-Kyu; Jarman, Richard G.; Klungthong, Chonticha; Valderama, Maria Theresa G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Mason, Carl J.; Bodhidatta, Ladaporn; Silapong, Sasikorn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Torres, Arturo G.; De Cecchis, Daniel P.] FPO AP, Unit 35621, Marine Expeditionary Unit 31, Marine Corps Base Camp Smedley D Butler, Okinawa 966065621, Japan.
RP Velasco, JMS (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
RI Valle, Ruben/A-7512-2013;
OI MASON, CARL/0000-0002-3676-2811
FU U.S. Armed Forces Health Surveillance Center - Global Emerging
Infections Surveillance and Response System, Silver Spring, Maryland
FX Funding for this work was partially provided by the U.S. Armed Forces
Health Surveillance Center - Global Emerging Infections Surveillance and
Response System, Silver Spring, Maryland. This research was conducted as
a public health measure and was determined as not human subjects
research by the Walter Reed Army Institute of Research Division of Human
Subjects Protection. Some of the authors are military service members.
This work was prepared as part of their official duties. Title 17 U.S.C.
105 provides that Copyright protection under this title is not available
for any work of the U.S. Government. Title 17 U.S.C. 101 defines a U.S.
Government work as a work prepared by a military service member or
employee of the U.S. Government as part of that person's official
duties.
NR 22
TC 1
Z9 1
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1096
EP 1100
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300004
PM 22128641
ER
PT J
AU Havas, KA
Burkman, K
AF Havas, Karyn A.
Burkman, Kay
TI A Comparison of the Serological Evidence of Coxiella burnetii Exposure
Between Military Working Dogs and Feral Canines in Iraq
SO MILITARY MEDICINE
LA English
DT Article
ID Q-FEVER
AB Coxiella burnetii is the causative agent of the zoonotic disease Q fever. Military working dogs (MWDs) are exposed to disease while deployed and are a potential source for human infection. This study assesses the exposure of MWDs via postdeployment antibody serology. In 2007 and 2008, 115 deployed MWDs and 165 feral Iraqi canines had blood samples taken and evaluated for antibodies to C. burnetii. None of the MWDs seroconverted, alleviating the need to consider predeployment titers, while 5.5% of feral canines seroconverted. This difference was significant with a p value of <0.05. MWD vector control measures and prophylactic doxycycline administration are effective in Q fever disease control and prevention. Thus, MWDs may be less effective as sentinels for human populations in regards to tick-borne diseases caused by C. burnetii. Nonetheless, veterinarians presented with an MWD with a fever of unknown origin should consider C. burnetii if the dog has recently redeployed, and if diagnosed should make the kennel master and medical treatment facility aware of the zoonotic risk.
C1 [Havas, Karyn A.] Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA.
[Havas, Karyn A.] Colorado State Univ, Anim Populat Hlth Inst, Ft Collins, CO 80523 USA.
[Burkman, Kay] USA, Vet Command Headquarters, Ft Sam Houston, TX 78234 USA.
RP Havas, KA (reprint author), Army Med Dept Ctr & Sch, 2355 Harney Rd, Ft Sam Houston, TX 78234 USA.
FU Global Emerging Infections Surveillances branch of the Armed Forces
Health Surveillance Center [C0091_09_OT]
FX This project was funded by a grant from the Global Emerging Infections
Surveillances branch of the Armed Forces Health Surveillance Center.
Grant No. C0091_09_OT.
NR 13
TC 2
Z9 2
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1101
EP 1103
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300005
PM 22128642
ER
PT J
AU Swedler, DI
Knapik, JJ
Williams, KW
Grier, TL
Jones, BH
AF Swedler, David I.
Knapik, Joseph J.
Williams, Kelly W.
Grier, Tyson L.
Jones, Bruce H.
TI Risk Factors for Medical Discharge From United States Army Basic Combat
Training
SO MILITARY MEDICINE
LA English
DT Article
ID PHYSICAL-FITNESS; BODY-FAT; PREDICTORS; INJURIES; SMOKING; SUCCESS;
ATTRITION; EXERCISE; RECRUITS; WOMEN
AB Past studies indicated that overall Basic Combat Training (BCT) attrition (discharge) was associated with various risk factors. BCT has changed considerably since many of these studies were conducted. This study examined Soldiers medically attrited from BCT. Potential attrition risk factor data on recruits (n = 4,005) were collected from medical records, BCT unit records, and questionnaires. Attrition data from Fort Jackson, South Carolina, showed 203 medical discharges. Cox regression (univariate and multivariate) obtained hazard ratios and 95% confidence intervals for attrition risk factors. Higher attrition risk was associated with female gender. Higher attrition risk for men was associated with cigarette smoking, injury during BCT, and less exercise before BCT. Higher attrition risk for both genders was associated with failure on the initial 2-mile run test and separated or divorced marital status. Attrition risk factors found in this study were similar to those previously identified despite changes in BCT.
C1 [Swedler, David I.] Johns Hopkins Univ, Ctr Injury Res & Policy, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
[Knapik, Joseph J.; Grier, Tyson L.; Jones, Bruce H.] USA, Injury Prevent Program, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21237 USA.
[Williams, Kelly W.] Basic Combat Training Ctr Excellence, Ft Jackson, SC 29207 USA.
RP Swedler, DI (reprint author), Johns Hopkins Univ, Ctr Injury Res & Policy, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, 624 N Broadway,Room 554, Baltimore, MD 21205 USA.
FU U.S. Army Center for Health Promotion and Preventive Medicine
(USACHPPM); U.S. Department of Energy; U.S. Defense Safety Oversight
Council
FX This research was supported in part by an appointment to the Student
Research Participation Program at the U.S. Army Center for Health
Promotion and Preventive Medicine (USACHPPM) administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement with the U.S. Department of Energy and USACHPPM. This study
was also funded by U.S. Defense Safety Oversight Council, Military
Physical Training Task Force Grant.
NR 40
TC 7
Z9 7
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1104
EP 1110
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300006
PM 22128643
ER
PT J
AU Herold, TJS
AF Herold, Thomas J. S.
TI The Evolution of Dependent Medical Care in the US Army
SO MILITARY MEDICINE
LA English
DT Article
AB There is great focus within the military medical community regarding the ever growing cost of medical care overall and dependent care specifically. A great deal of discussion relates to the delivery of care through a growing military civilian partnership, where an increased amount of health care will be referred to an ever growing network of civilian providers. The U.S. military establishment now stands at an important crossroad leading into the future of dependent care. However, the special concerns, which arise from the responsibility of caring for military dependents, are not a solely recent phenomenon. Ever since the establishment of a permanent standing U.S. Army in the late 1700s, there have been families in need of medical treatment. Although changes occurred continuously, the development and evolution of policies regulating the delivery of medical care to dependants can be divided into three periods. The first is the longest and ranges from the establishment of the Army until the year 1900. The second period spans from 1900 to the post-Korean War year of 1956. The third and final period is from 1956 to 1975. Special changes and advances in each of these periods have served to shape the face of dependent care in today's Army Medical Department.
C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Herold, TJS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Blvd, Ft Sam Houston, TX 78234 USA.
NR 18
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1133
EP 1137
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300011
PM 22128648
ER
PT J
AU Kragh, JF
O'Neill, ML
Walters, TJ
Dubick, MA
Baer, DG
Wade, CE
Holcomb, JB
Blackbourne, LH
AF Kragh, John F., Jr.
O'Neill, Michelle L.
Walters, Thomas J.
Dubick, Michael A.
Baer, David G.
Wade, Charles E.
Holcomb, John B.
Blackbourne, Lorne H.
TI The Military Emergency Tourniquet Program's Lessons Learned With Devices
and Designs
SO MILITARY MEDICINE
LA English
DT Article
ID MAJOR LIMB TRAUMA; OCCLUSION; PRESSURES; CUFFS
AB Objective: The purpose of this study is to report the device lessons learned from an emergency tourniquet program and, in particular, to emphasize analysis of discarded devices recovered after clinical use. Methods: Discarded tourniquet devices were analyzed after use in emergency care of war casualties to determine wear and tear patterns, effectiveness rates, and associations among device designs. Results: The 159 devices recovered comprised seven designs. Emergency & Military Tourniquet (92%) and Combat Application Tourniquet (79%) effectiveness rates were significantly different from each other and better than other tourniquets (p < 0.002) as the most effective ambulance and field tourniquets, respectively. Designs had specific pitfalls (e.g., sand-clogged ratchets) and strengths (the pneumatic design was least painful). Every device had wear, abrasions, or deformity about the band edges or bladder. User understanding of how devices work best helped attain better results. Some desirable traits (e.g., one-handed application, use for entrapped limbs) were rarely needed. Tourniquets fit casualty limbs well. Conclusions: Correct user actions (e.g., following the instructions to remove slack before twisting) led to device effectiveness, but misuse did not. Users often assumed that optimal use required more force, but this was associated with misuse. Training should include tourniquet pearls and pitfalls.
C1 [Kragh, John F., Jr.; Walters, Thomas J.; Dubick, Michael A.; Baer, David G.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[O'Neill, Michelle L.] USA, Brigade Combat Team 2, Infantry Div 25, Schofield Barracks, HI 96857 USA.
[Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA.
RP Kragh, JF (reprint author), USA, Inst Surg Res, 3611 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
FU USAISR
FX Otilia Sanchez aided in manuscript preparation. Funding of this project
was with internal USAISR funds and not from any of the following
organizations: National Institutes of Health (NIH); Wellcome Trust;
Howard Hughes Medical Institute (HHMI), or other.
NR 10
TC 15
Z9 15
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1144
EP 1152
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300013
PM 22128650
ER
PT J
AU Waibel, KH
Haney, B
Moore, M
Whisman, B
Gomez, R
AF Waibel, Kirk H.
Haney, Brian
Moore, Merrideth
Whisman, Bonnie
Gomez, Robert
TI Safety of Chitosan Bandages in Shellfish Allergic Patients
SO MILITARY MEDICINE
LA English
DT Article
ID SEAFOOD ALLERGY; GLUCOSAMINE; HEMORRHAGE
AB Background: In 2005, the Office of the Surgeon General mandated that every soldier carry a Hem Con bandage. Made from chitosan, a polysaccharide derived from shrimp shells, this bandage effectively stops bleeding. There are no studies reporting the safety of this bandage in shellfish allergic patients. Methods: Patients who reported shellfish allergy were recruited. Initial assessment included a detailed history, IgE skin prick testing (SPT), and serum testing to shellfish allergens. Participants who demonstrated specific shellfish IgE underwent a bandage challenge. Results: Nineteen participants were enrolled; 10 completed the study. Seven (70%) were male and the average age was 44.8 + 10 years. Nine (90%) reported a shrimp allergy history and five (50%) reported multiple shellfish allergies. All participants completing the study had positive SPT and serum IgE testing to at least one shellfish; eight (80%) had shrimp positive SPT and ten (100%) demonstrated shrimp-specific IgE. No participant had a positive SPT to chitosan powder or experienced an adverse reaction during bandage challenges. No protein bands were visualized during gel electrophoresis analysis of chitosan powder. Conclusion: All participants tolerated the Hem Con bandage without reaction. This is the first study demonstrating the safety of this bandage in shellfish allergic subjects.
C1 [Waibel, Kirk H.; Haney, Brian] Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA.
[Moore, Merrideth; Whisman, Bonnie; Gomez, Robert] Wilford Hall USAF Med Ctr, Dept Med, Allergy Immunol Serv, Lackland AFB, TX 78236 USA.
RP Waibel, KH (reprint author), Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 9
TC 18
Z9 20
U1 2
U2 11
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1153
EP 1156
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300014
PM 22128651
ER
PT J
AU Morris, MJ
Zacher, LL
Jackson, DA
AF Morris, Michael J.
Zacher, Lisa L.
Jackson, David A.
TI Investigating the Respiratory Health of Deployed Military Personnel
SO MILITARY MEDICINE
LA English
DT Article
ID ACUTE EOSINOPHILIC PNEUMONIA; GULF-WAR VETERANS; KUWAIT OIL FIRES; ASIAN
SAND DUST; CONSTRICTIVE BRONCHIOLITIS; PARTICULATE MATTER; US;
AFGHANISTAN; SYMPTOMS; EXPOSURE
AB Recent news media articles have implied a direct relationship between environmental exposures such as burn pits during current deployments and the development of serious and debilitating chronic pulmonary disease. These articles suggest that the military is superficially investigating evidence that establishes a link between deployment and development of chronic lung disease. Anecdotal cases of military personnel with lung disease are detailed to suggest a systemic problem with undiagnosed and untreated pulmonary disease in deployed service members. Despite these contentions, the U.S. Army Medical Department and other agencies have been actively pursuing numerous scientific investigations into deployment-related lung disease to define the severity and prevalence of the issue. This article will review relevant research efforts by the U.S. military in the existing medical literature and address the current efforts planned by the services to systematically investigate the possibility of deployment-related pulmonary disease.
C1 [Morris, Michael J.; Zacher, Lisa L.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Jackson, David A.] USA, Biomarkers Program, Ctr Environm Hlth Med Res & Med Command, Ft Detrick, MD 21702 USA.
RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RI Jackson, David/E-9984-2014
NR 31
TC 14
Z9 14
U1 0
U2 14
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1157
EP 1161
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300015
PM 22128652
ER
PT J
AU Enewold, L
Zhou, J
Devesa, SS
Erickson, RL
Zhu, KM
McGlynn, KA
AF Enewold, Lindsey
Zhou, Jing
Devesa, Susan S.
Erickson, Ralph L.
Zhu, Kangmin
McGlynn, Katherine A.
TI Trends in Testicular Germ Cell Tumors Among US Military Servicemen,
1990-2003
SO MILITARY MEDICINE
LA English
DT Article
ID UNITED-STATES; CANCER; RATES
AB Objective: To determine the incidence of testicular germ cell tumors among active duty males and compare it with the incidence in the general U.S. population. Methods: The Automated Cancer Tumor Registry and the Surveillance, Epidemiology, and End Results Program data from 1990 to 2003 were analyzed for men aged between 20 and 59 years by histology and stage at diagnosis. Rates were age adjusted using the male active duty military population as the standard. Results: Nonseminoma incidence was significantly lower in the military than in the general population (incidence rate ratio = 0.90, 95% confidence interval = 0.82-0.98). Trends in incidence tended to be similar in both the populations. Increases were observed for both histologic types but were only significant for seminoma (Automated Cancer Tumor Registry: 21% and Surveillance, Epidemiology, and End Results program: 16%; p < 0.05). Increases in incidence were only observed for localized tumors of both histologic types. Conclusions: The lower incidence of non-seminoma in the military and the increased incidence of localized tumors in both populations remain unexplained.
C1 [Enewold, Lindsey; Zhou, Jing; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
[Devesa, Susan S.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Enewold, L (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, 6900 Georgia Ave NW,Bldg 1,Suite A 109, Washington, DC 20307 USA.
FU Division of Cancer Epidemiology and Genetics, National Cancer Institute,
National Institutes of Health, Department of Health and Human Services;
United States Military Cancer Institute via the Uniformed Services
University of the Health Sciences under Henry M. Jackson Foundation for
the Advancement of Military Medicine
FX This study was partly supported by the Intramural Research Program of
the Division of Cancer Epidemiology and Genetics, National Cancer
Institute, National Institutes of Health, Department of Health and Human
Services, and by the United States Military Cancer Institute via the
Uniformed Services University of the Health Sciences under the auspices
of the Henry M. Jackson Foundation for the Advancement of Military
Medicine.
NR 15
TC 4
Z9 5
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1184
EP 1187
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300019
PM 22128656
ER
PT J
AU Frattalone, AR
Neely, ET
AF Frattalone, Anthony R.
Neely, Edward T.
TI Positional Headache Associated With a Dilated Cyst of the Septum
Pellucidum
SO MILITARY MEDICINE
LA English
DT Article
ID CAVUM VERGAE
AB Objective: A cavum septum pellucidum is an anatomical variant that is usually considered an incidental finding of little clinical significance. This is a fluid-containing structure between the lateral ventricles whose walls exhibit lateral bowing and are 10-mm apart or greater. It has been hypothesized that enlarged cysts of this type may cause hydrocephalus and resultant headache (HA), but there have been very few reports in the literature and even fewer reports of successful treatments. Methods: We describe a patient with subacute onset of positional HA who was found to have a large dilated cavum cyst on magnetic resonance imaging. Results: The patient underwent endoscopic fenestration of the cyst, which eradicated his HAs. Conclusions: We hypothesize that this patient's large cavum septum pellucidum cyst was causing intermittent, positional hydrocephalus and thus HAs. This is a very unusual but highly treatable cause of positional HA that could be overlooked easily.
C1 [Frattalone, Anthony R.] Johns Hopkins Univ, Neurosci Crit Care Div, Sch Med, Baltimore, MD 21287 USA.
[Neely, Edward T.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA.
RP Frattalone, AR (reprint author), Johns Hopkins Univ, Neurosci Crit Care Div, Sch Med, 600 N Wolfe St,Meyer 8-140, Baltimore, MD 21287 USA.
NR 10
TC 1
Z9 1
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2011
VL 176
IS 10
BP 1202
EP 1203
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 831EK
UT WOS:000295711300023
PM 22128660
ER
PT J
AU Munger, KL
Levin, LI
O'Reilly, EJ
Falk, KI
Ascherio, A
AF Munger, K. L.
Levin, L. I.
O'Reilly, E. J.
Falk, K. I.
Ascherio, A.
TI Anti-Epstein-Barr virus antibodies as serological markers of multiple
sclerosis: a prospective study among United States military personnel
SO MULTIPLE SCLEROSIS JOURNAL
LA English
DT Article
DE Epstein-Barr virus; epidemiology; nested case-control study; risk factor
ID ENVIRONMENTAL RISK-FACTORS; SUSCEPTIBILITY LOCI; IMMUNE-RESPONSE;
T-CELLS; INFECTION; BRAIN; HLA-DRB1-ASTERISK-1501; METAANALYSIS;
ASSOCIATION; EBV
AB Background: Elevated Epstein-Barr virus (EBV) antibody titers are risk factors for multiple sclerosis ( MS), but the strength and consistency of this association are not well characterized.
Objectives: The objectives of this study were to determine whether this association is confounded by vitamin D or modified by gender or race, and the usefulness of EBV nuclear antigen (EBNA) antibodies as a marker for MS.
Methods: We conducted a prospective study among US military personnel. Antibody titers against EBV antigens were measured in serum samples from 222 individuals who developed MS and 444 age, sex, and race/ethnicity matched controls. Conditional logistic regression was used to estimate relative risks.
Results: MS risk increased with increasing titers of anti-EBNA complex (p < 10(-9)) and anti-EBNA-1 (p = 5.8 x 10(-9)) titers. MS risk was 36-fold higher among individuals with anti-EBNA complex IgG titers >= 320 than among those with titers < 20 (95% confidence interval [CI] 9.6-136), and 8-fold higher among those with anti-EBNA-1 >= 320 than among those with anti-EBNA-1 < 20 (95% CI 2.6-23). These associations were consistent across gender and race/ethnicity groups and independent from 25-hydroxyvitamin D levels. Areas under the receiver operating characteristic (ROC) curves were 0.67 for EBNA complex and 0.65 for EBNA-1.
Conclusions: Serum titers of pre-onset anti-EBNA antibodies are strong, robust markers of MS risk and could be useful in an MS risk score.
C1 [Munger, K. L.; O'Reilly, E. J.; Ascherio, A.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Levin, L. I.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD USA.
[Falk, K. I.] Karolinska Inst, Dept Preparedness, Swedish Inst Communicable Dis Control, S-10401 Stockholm, Sweden.
[Falk, K. I.] Karolinska Inst, MTC, S-10401 Stockholm, Sweden.
[Ascherio, A.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Ascherio, A.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
[Ascherio, A.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
RP Munger, KL (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA.
EM kgorham@hsph.harvard.edu
FU National Institute of Neurological Disorders and Stroke [NS042194,
NS046635]
FX This work was supported by the National Institute of Neurological
Disorders and Stroke (grant number NS042194 and NS046635).
NR 34
TC 67
Z9 67
U1 1
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1352-4585
J9 MULT SCLER J
JI Mult. Scler. J.
PD OCT
PY 2011
VL 17
IS 10
BP 1185
EP 1193
DI 10.1177/1352458511408991
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 830YH
UT WOS:000295695100009
PM 21685232
ER
PT J
AU Helgeson, MD
Lehman, RA
Dmitriev, AE
Kang, DG
Sasso, RC
Tannoury, C
Riew, KD
AF Helgeson, Melvin D.
Lehman, Ronald A., Jr.
Dmitriev, Anton E.
Kang, Daniel G.
Sasso, Rick C.
Tannoury, Chadi
Riew, K. Daniel
TI Accuracy of the freehand technique for 3 fixation methods in the C-2
vertebrae
SO NEUROSURGICAL FOCUS
LA English
DT Article
DE intralaminar screw; pedicle screw; pars screw; freehand technique;
cervical spine; fixation
ID TRANSARTICULAR SCREW FIXATION; C2 LAMINAR SCREWS; ATLANTOAXIAL FIXATION;
C1-C2 FUSION; PEDICLE; ARTERY; SUITABILITY; PLACEMENT; EROSION; COMPLEX
AB Object. Intraoperative imaging often does not provide adequate visualization to ensure safe placement of screws. Therefore, the authors investigated the accuracy of a freehand technique for placement of pars, pedicle, and intralaminar screws in C-2.
Methods. Sixteen cadaveric specimens were instrumented freehand by 2 experienced cervical spine surgeons with either a pars or pedicle screw, and bilateral intralaminar screws. The technique was based on anatomical starting points and published screw trajectories. A pedicle finder was used to establish the trajectory, followed by tapping, palpation, and screw placement. After placement of all screws (16 pars screws, 16 pedicle screws, and 32 intralaminar screws), the C-2 segments were disarticulated, radiographed in anteroposterior, lateral, and axial planes, and meticulously inspected by another spine surgeon to determine the nature and presence of any defects.
Results. A total of 64 screws were evaluated in this study. Pars screws exhibited 2 critical defects (1 in the foramen transversarium and 1 in the C2-3 facet) and an insignificant dorsal cortex breech, for an overall accuracy rate of 81.3%. Pedicle screws demonstrated only 1 insignificant violation (inferior facet/medial cortex intrusion of 1 mm) with an accuracy rate of 93.8%, and intralaminar screws demonstrated 3 insignificant violations (2 in the ventral canal, 1 in the caudad lamina breech) for an accuracy rate of 90.6%. Pars screws had significantly more critical violations than intralaminar screws (p = 0.041).
Conclusions. Instrumentation of the C-2 vertebrae using the freehand technique for insertion of pedicle and intralaminar screws showed a high success rate with no critical violations. Pars screw insertion was not as reliable, with 2 critical violations from a total of 16 placements. The freehand technique appears to be a safe and reliable method for insertion of C-2 pedicle and intralaminar screws. (DOI: 10.3171/2011.6.FOCUS1167)
C1 [Helgeson, Melvin D.; Lehman, Ronald A., Jr.; Dmitriev, Anton E.; Kang, Daniel G.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA.
[Sasso, Rick C.] Indiana Univ, Sch Med, Indiana Spine Grp, Indianapolis, IN USA.
[Tannoury, Chadi] Thomas Jefferson Univ Hosp, Dept Paediat Orthopaed, Philadelphia, PA 19107 USA.
[Riew, K. Daniel] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA.
RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed Surg & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM armyspine@yahoo.com
OI Tannoury, Chadi/0000-0002-2369-432X
NR 26
TC 5
Z9 5
U1 0
U2 4
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1092-0684
J9 NEUROSURG FOCUS
JI Neurosurg. Focus
PD OCT
PY 2011
VL 31
IS 4
AR E11
DI 10.3171/2011.6.FOCUS1167
PG 5
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 827DE
UT WOS:000295406500012
PM 21961855
ER
PT J
AU Helwig, BG
Leon, LR
AF Helwig, Bryan G.
Leon, Lisa R.
TI Tissue and circulating expression of IL-1 family members following heat
stroke
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE liver; spleen; hypothermia; heat stress; cytokines
ID INTERLEUKIN-1 RECEPTOR ANTAGONIST; SYSTEMIC INFLAMMATORY RESPONSE; RAT
HEATSTROKE; BODY-TEMPERATURE; CYTOKINES; MICE; IL-1-ALPHA; RELEASE;
ANESTHESIA; IL-1-BETA
AB Helwig BG, Leon LR. Tissue and circulating expression of IL-1 family members following heat stroke. Physiol Genomics 43: 1096-1104, 2011. First published August 9, 2011; doi: 10.1152/physiolgenomics.00076.2011.-Interleukin-1 (IL-1) is thought to have a significant role in the pathophysiology of heat stroke (HS), although little is known regarding the actions or expression patterns of the IL-1 family. This study tested the hypotheses that following HS IL-1 family gene expression is dynamic, while loss of IL-1 signaling enhances recovery. IL-1 family expression was determined in plasma, spleen, and liver from C57BL/6J mice (n = 24 control, n = 20 HS) at maximum core temperature (T(c,Max)), hypothermia, and 24 h post-HS (24 h). Soluble IL-1 receptor subtype I (sIL-1RI) protein expression peaked at 24 h (14,659.01 +/- 2,016.28 pg/ml, P < 0.05), while sIL-1RII peaked at hypothermia (19,099.30 +/- 1,177.07 pg/ml). IL-1 alpha gene expression in the spleen (ninefold) and liver (fourfold) along with IL-1RI (threefold spleen and fivefold liver) were maximal at hypothermia. Spleen IL-1 beta gene expression peaked at T(c,Max) (fourfold) but at hypothermia (fourfold) in liver. Gene expression of the IL-1 family member IL-18 peaked (2.5-fold) at T(c,Max) but was similar at all other time points. Subsequent studies revealed that despite accruing a greater heating area (298 +/- 16 vs. 247 +/- 13 degrees C.min, P < 0.05), IL-1RI knockout (KO) mice (n = 14) showed an attenuated hypothermia depth (28.5 +/- 0.2 vs. 27.3 +/- 0.5 degrees C, P < 0.05) and duration (675 +/- 82 vs. 1,283 +/- 390 min, P < 0.05) with a higher 24 h T(c) (36.9 vs. 34.1 degrees C, P < 0.05) compared with C57BL/6J mice (n = 8). The current results demonstrate that following HS IL-1 family gene expression is altered and IL-1RI KO mice display T(c) responses consistent with a more rapid recovery.
C1 [Helwig, Bryan G.; Leon, Lisa R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP Helwig, BG (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42,Rm 343, Natick, MA 01760 USA.
EM Bryan.helwig@us.army.mil
FU US Army Medical Research and Materiel Command
FX Research funded by US Army Medical Research and Materiel Command.
Approved for public release; distribution is unlimited.
NR 46
TC 16
Z9 19
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD OCT
PY 2011
VL 43
IS 19
BP 1096
EP 1104
DI 10.1152/physiolgenomics.00076.2011
PG 9
WC Cell Biology; Genetics & Heredity; Physiology
SC Cell Biology; Genetics & Heredity; Physiology
GA 829VT
UT WOS:000295613700003
PM 21828249
ER
PT J
AU Conway, DG
Baden, E
Anderson, K
Summers, S
AF Conway, D. G.
Baden, E.
Anderson, K.
Summers, S.
TI Emergency Department Patients Evaluated by Bedside Biliary
Ultrasonography: Does Radiology Uitrasonography Alter Disposition?
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Meeting Abstract
CT Annual Research Forum of the American-College-of-Emergency-Physicians
CY OCT 15-16, 2011
CL San Francisco, CA
SP Amer Coll Emergency Phys
C1 [Conway, D. G.; Baden, E.; Anderson, K.; Summers, S.] Brooke Army Med Ctr, SAUSHEC, Ft Sam Houston, TX 78234 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD OCT
PY 2011
VL 58
IS 4
SU S
BP S195
EP S195
PG 1
WC Emergency Medicine
SC Emergency Medicine
GA 827ID
UT WOS:000295421300053
ER
PT J
AU Gerhardt, RT
Berry, J
Blackbourne, LH
AF Gerhardt, R. T.
Berry, J.
Blackbourne, L. H.
TI Application of Emergency Telemedical Direction to Improve Combat
Casualty Care at an Out-of-Hospital Medical Treatment Facility
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Meeting Abstract
CT Annual Research Forum of the American-College-of-Emergency-Physicians
CY OCT 15-16, 2011
CL San Francisco, CA
SP Amer Coll Emergency Phys
C1 USA, Inst Surg Res, BAMC, Ft Sam Houston, TX 78234 USA.
Brooke Army Med Ctr, Special Forces Grp Airborne 10, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD OCT
PY 2011
VL 58
IS 4
SU S
BP S270
EP S270
PG 1
WC Emergency Medicine
SC Emergency Medicine
GA 827ID
UT WOS:000295421300277
ER
PT J
AU Lairet, JR
McCafferty, R
Lairet, K
Muck, A
Balls, A
Minnick, J
Torres, P
King, J
AF Lairet, J. R.
McCafferty, R.
Lairet, K.
Muck, A.
Balls, A.
Minnick, J.
Torres, P.
King, J.
TI Critical Care Air Transport Team (CCATT) Short Term Outcomes of
Casualties With Spinal Fractures Moved With the Vacuum Spine Board
Between 2009 and 2010
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Meeting Abstract
CT Annual Research Forum of the American-College-of-Emergency-Physicians
CY OCT 15-16, 2011
CL San Francisco, CA
SP Amer Coll Emergency Phys
C1 Wilford Hall USAF Med Ctr, Lackland AFB, TX USA.
USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD OCT
PY 2011
VL 58
IS 4
SU S
BP S241
EP S241
PG 1
WC Emergency Medicine
SC Emergency Medicine
GA 827ID
UT WOS:000295421300190
ER
PT J
AU Cameron, KL
Hsiao, MS
Owens, BD
Burks, R
Svoboda, SJ
AF Cameron, Kenneth L.
Hsiao, Mark S.
Owens, Brett D.
Burks, Robert
Svoboda, Steven J.
TI Incidence of Physician-Diagnosed Osteoarthritis Among Active Duty United
States Military Service Members
SO ARTHRITIS AND RHEUMATISM
LA English
DT Article
ID SYMPTOMATIC KNEE OSTEOARTHRITIS; ANTERIOR CRUCIATE LIGAMENT; HIP
OSTEOARTHRITIS; RISK-FACTORS; FRAMINGHAM OSTEOARTHRITIS; RHEUMATIC
CONDITIONS; BRITISH-COLUMBIA; NATIONAL-HEALTH; PUBLIC-HEALTH; US-ARMY
AB Objective. To examine the incidence of osteoarthritis and the influence of demographic and occupational factors associated with this condition among active duty US service members between 1999 and 2008.
Methods. To determine the total number of incident cases of osteoarthritis, the Defense Medical Surveillance System (DMSS) was queried by sex, race, age, branch of military service, and rank using code 715 of the International Classification of Diseases, Ninth Revision, Clinical Modification. Multivariable Poisson regression analysis was used to estimate incidence rates, rate ratios, and 95% confidence intervals (95% CIs) for osteoarthritis per 1,000 person-years.
Results. A total of 108,266 incident cases of osteoarthritis were documented in the DMSS within a population that experienced 13,768,885 person-years at risk of disease during the study period. The overall unadjusted incidence rate among all active duty US service members during the study period was 7.86 cases per 1,000 person-years. Significant demographic and occupational risk factors for osteoarthritis included sex, age, race, branch of service, and rank (P < 0.001). Women experienced an adjusted incidence rate for osteoarthritis that was nearly 20% higher than that for men (rate ratio 1.19 [95% CI 1.17-1.21]). Service members ages >= 40 years experienced an adjusted incidence rate for osteoarthritis that was similar to 19 times higher than that for those ages <20 years (rate ratio 18.61 [95% CI 17.57-19.57]). Black service members experienced significantly higher incidence rates of osteoarthritis than those in the white and "other" race categories.
Conclusion. Rates of osteoarthritis were significantly higher in military populations than in comparable age groups in the general population.
C1 [Cameron, Kenneth L.; Hsiao, Mark S.; Owens, Brett D.; Svoboda, Steven J.] Keller Army Community Hosp, West Point, NY 10996 USA.
[Burks, Robert] Naval Postgrad Sch, Monterey, CA USA.
RP Cameron, KL (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM kenneth.cameron@amedd.army.mil
RI Burks, Robert/J-2481-2015;
OI Burks, Robert/0000-0001-6443-6653; Cameron, Kenneth/0000-0002-6276-4482
NR 55
TC 21
Z9 21
U1 1
U2 15
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0004-3591
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2011
VL 63
IS 10
BP 2974
EP 2982
DI 10.1002/art.30498
PG 9
WC Rheumatology
SC Rheumatology
GA 825PN
UT WOS:000295293000016
PM 21717422
ER
PT J
AU Blacksell, SD
Tanganuchitcharnchai, A
Jarman, RG
Gibbons, RV
Paris, DH
Bailey, MS
Day, NPJ
Premaratna, R
Lalloo, DG
de Silva, HJ
AF Blacksell, Stuart D.
Tanganuchitcharnchai, Ampai
Jarman, Richard G.
Gibbons, Robert V.
Paris, Daniel H.
Bailey, Mark S.
Day, Nicholas P. J.
Premaratna, Ranjan
Lalloo, David G.
de Silva, H. Janaka
TI Poor Diagnostic Accuracy of Commercial Antibody-Based Assays for the
Diagnosis of Acute Chikungunya Infection
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID REAL-TIME DETECTION; VIRUSES; FEVER; EPIDEMIC
AB A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
C1 [Blacksell, Stuart D.; Tanganuchitcharnchai, Ampai; Paris, Daniel H.; Day, Nicholas P. J.] Mahidol Univ, Fac Trop Med, Oxford Trop Med Res Unit, Bangkok 10400, Thailand.
[Blacksell, Stuart D.; Paris, Daniel H.; Day, Nicholas P. J.] Univ Oxford, Ctr Trop Med, Oxford OX3 7LJ, England.
[Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Bailey, Mark S.] Royal Ctr Def Med, Dept Mil Med, Birmingham B15 2SQ, W Midlands, England.
[Premaratna, Ranjan; de Silva, H. Janaka] Univ Kelaniya, Dept Med, Ragama, Sri Lanka.
[Lalloo, David G.] Univ Liverpool, Liverpool Sch Trop Med, Clin Res Grp, Liverpool L3 5QA, Merseyside, England.
RP Blacksell, SD (reprint author), Mahidol Univ, Fac Trop Med, Oxford Trop Med Res Unit, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM stuart@tropmedres.ac
RI Bailey, Mark/D-3854-2013;
OI Bailey, Mark/0000-0003-4840-5093; Blacksell, Stuart/0000-0001-6576-726X
FU Wellcome Trust [078990/Z/06/Z]; United Kingdom Defense Postgraduate
Medical Deanery; University of Kelaniya; Wellcome Trust of Great Britain
FX D.H.P. was supported by a Wellcome Trust Clinical Research Training
Fellowship (078990/Z/06/Z). The study was funded by grants from the
United Kingdom Defense Postgraduate Medical Deanery, the University of
Kelaniya, and the Wellcome Trust of Great Britain.
NR 13
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U1 1
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD OCT
PY 2011
VL 18
IS 10
BP 1773
EP 1775
DI 10.1128/CVI.05288-11
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 826NQ
UT WOS:000295361300025
PM 21865416
ER
PT J
AU Nayfeh, OM
AF Nayfeh, Osama M.
TI Graphene Transistors on Mechanically Flexible Polyimide Incorporating
Atomic-Layer-Deposited Gate Dielectric
SO IEEE ELECTRON DEVICE LETTERS
LA English
DT Article
DE Flexible; graphene; polyimide; transistors
ID FIELD-EFFECT TRANSISTORS; HIGH-QUALITY; LARGE-AREA; FILMS; SCATTERING
AB Transistors are constructed using chemical-vapor-deposited graphene on mechanically flexible polyimide and incorporate a low-temperature atomic-layer-deposited gate dielectric. Three-micrometer gate length transistors with V(ds) = 2.0 V have a drive current of > 0.3 A/mm with a transconductance of > 3 mS/mm. The peak hole and electron mobilities are 295 and 106 cm(2)/V . s, respectively. Subsequent to repeated flexing, the ambipolar characteristics and extremely low gate leakage remain intact with < 15% reduction in the peak carrier mobility. Good agreement is obtained between the measured mobility and a physically based empirical model and is consistent with the mobility limited by impurity levels and surface roughness. Using graphene-on-polyimide transistors, radio-frequency functionalities, including signal amplification and phase shifting, are demonstrated, and routes for performance improvement are discussed. The results are important for the development of graphene-based electronics on mechanically flexible substrates.
C1 USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Nayfeh, OM (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
EM osama.nayfeh@us.army.mil
NR 19
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Z9 16
U1 6
U2 38
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0741-3106
J9 IEEE ELECTR DEVICE L
JI IEEE Electron Device Lett.
PD OCT
PY 2011
VL 32
IS 10
BP 1349
EP 1351
DI 10.1109/LED.2011.2163489
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA 826GH
UT WOS:000295340300011
ER
PT J
AU House, JM
AF House, Jonathan M.
TI Stalin's Romeo Spy: The Remarkable Rise and Fall of the KGB's Most
Daring Operative. The True Life of Dmitri Bystrolyotov
SO RUSSIAN REVIEW
LA English
DT Book Review
C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0036-0341
J9 RUSS REV
JI Russ. Rev.
PD OCT
PY 2011
VL 70
IS 4
BP 708
EP 709
PG 2
WC History
SC History
GA 822MG
UT WOS:000295051100037
ER
PT J
AU Fritz, JM
Koppenhaver, SL
Kawchuk, GN
Teyhen, DS
Hebert, JJ
Childs, JD
AF Fritz, Julie M.
Koppenhaver, Shane L.
Kawchuk, Gregory N.
Teyhen, Deydre S.
Hebert, Jeffrey J.
Childs, John D.
TI Preliminary Investigation of the Mechanisms Underlying the Effects of
Manipulation Exploration of a Multivariate Model Including Spinal
Stiffness, Multifidus Recruitment, and Clinical Findings
SO SPINE
LA English
DT Article
DE low back pain; spinal manipulation; spinal stiffness; lumbar multifidus
ID LOW-BACK-PAIN; LUMBAR SPINE; TRANSVERSUS ABDOMINIS; EXCITABILITY
CHANGES; PARASPINAL MUSCLES; SEGMENTAL MOBILITY; PREDICTION RULE;
MOBILIZATION; RELIABILITY; THERAPY
AB Study Design. Prospective case series.
Objective. To examine spinal stiffness in patients with low back pain (LBP) receiving spinal manipulative therapy (SMT), evaluate associations between stiffness characteristics and clinical outcome, and explore a multivariate model of SMT mechanisms as related to effects on stiffness, lumbar multifidus (LM) recruitment, and status on a clinical prediction rule (CPR) for SMT outcomes.
Summary of Background Data. Mechanisms underlying the clinical effects of SMT are poorly understood. Many explanations have been proposed, but few studies have related potential mechanisms to clinical outcomes or considered multiple mechanisms concurrently.
Methods. Patients with LBP were treated with two SMT sessions over 1 week. CPR status was assessed at baseline. Clinical outcome was based on the Oswestry disability index (ODI). Mechanized indentation measures of spinal stiffness and ultrasonic measures of LM recruitment were taken before and after each SMT, and after 1 week. Global and terminal stiffness were calculated. Multivariate regression was used to evaluate the relationship between stiffness variables and percentage ODI improvement. Zero-order correlations among stiffness variables, LM recruitment changes, CPR status, and clinical outcome were examined. A path analysis was used to evaluate a multivariate model of SMT effects.
Results. Forty-eight patients (54% women) had complete stiffness data. Significant immediate decreases in global and terminal stiffness occurred post-SMT regardless of outcome. ODI improvement was related to greater immediate decrease in global stiffness (P = 0.025), and less initial terminal stiffness (P = 0.01). Zero-order correlations and path analysis supported a multivariate model suggesting that clinical outcome of SMT is mediated by improvements in LM recruitment and immediate decrease in global stiffness. Initial terminal stiffness and CPR status may relate to outcome though their relationship with LM recruitment.
Conclusion. The underlying mechanisms explaining the benefits of SMT appear to be multifactorial. Both spinal stiffness characteristics and LM recruitment changes appear to play a role.
C1 [Fritz, Julie M.] Univ Utah, Salt Lake City, UT 84108 USA.
[Kawchuk, Gregory N.] Univ Alberta, Dept Phys Therapy, Edmonton, AB, Canada.
[Teyhen, Deydre S.] USA, Med Dept Ctr & Sch, USA Baylor Univ Doctoral Program Phys Therapy MCC, Ctr Phys Therapy Res, San Antonio, TX USA.
[Hebert, Jeffrey J.] Murdoch Univ, Sch Chiropract & Sports Sci, Murdoch, WA 6150, Australia.
RP Fritz, JM (reprint author), Univ Utah, 520 Wakara Way, Salt Lake City, UT 84108 USA.
EM julie.fritz@hsc.utah.edu
RI Hebert, Jeffrey/C-4614-2008
OI Hebert, Jeffrey/0000-0002-6959-325X
FU NCCIH NIH HHS [R21 AT004221, R21 AT004221-01A1]
NR 64
TC 31
Z9 31
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD OCT 1
PY 2011
VL 36
IS 21
BP 1772
EP 1781
DI 10.1097/BRS.0b013e318216337d
PG 10
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 825YK
UT WOS:000295318000018
PM 21358568
ER
PT J
AU Mitrophanov, AY
Reifman, J
AF Mitrophanov, Alexander Y.
Reifman, Jaques
TI Kinetic modeling sheds light on the mode of action of recombinant factor
VIIa on thrombin generation
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Coagulation; Coagulopathy; Computational modeling; rFVIIa; Therapeutic;
Thrombin
ID ACTIVATED FACTOR-VII; DOSE FACTOR VIIA; TISSUE FACTOR PATHWAY;
FRESH-FROZEN PLASMA; BLOOD-COAGULATION; DILUTIONAL COAGULOPATHY;
IN-VITRO; TRAUMATIC HEMORRHAGE; MATHEMATICAL-MODEL; HEMOPHILIA-A
AB Introduction. The therapeutic potential of a hemostatic agent can be assessed by investigating its effects on the quantitative parameters of thrombin generation. For recombinant activated factor VII (rFVIIa) - a promising hemostasis-inducing biologic - experimental studies addressing its effects on thrombin generation yielded disparate results. To elucidate the inherent ability of rFVIIa to modulate thrombin production, it is necessary to identify rFVIIa-induced effects that are compatible with the available biochemical knowledge about thrombin generation mechanisms.
Materials and Methods. The existing body of knowledge about coagulation biochemistry can be rigorously represented by a computational model that incorporates the known reactions and parameter values constituting the biochemical network. We used a thoroughly validated numerical model to generate activated factor VII (FVIIa) titration curves in the cases of normal blood composition, hemophilia A and B blood, blood lacking factor VII, blood lacking tissue factor pathway inhibitor, and diluted blood. We utilized the generated curves to perform systematic fold-change analyses for five quantitative parameters characterizing thrombin accumulation.
Results. The largest fold changes induced by increasing FVIIa concentration were observed for clotting time, thrombin peak time, and maximum slope of the thrombin curve. By contrast, thrombin peak height was much less affected by FVIIa titrations, and the area under the thrombin curve stayed practically unchanged. Comparisons with experimental data demonstrated that the computationally derived patterns can be observed in vitro.
Conclusions. rFVIIa modulates thrombin generation primarily by accelerating the process, without significantly affecting the total amount of generated thrombin. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, Ft Detrick, MD 21702 USA.
RP Mitrophanov, AY (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
EM alex@bioanalysis.org; jaques.reifman@us.army.mil
NR 69
TC 26
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U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD OCT
PY 2011
VL 128
IS 4
BP 381
EP 390
DI 10.1016/j.thromres.2011.05.013
PG 10
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA 824OS
UT WOS:000295212200024
PM 21641634
ER
PT J
AU Abuzeid, M
Dalton, SR
Ferringer, T
Bernert, R
Elston, DM
AF Abuzeid, Margaret
Dalton, Scott R.
Ferringer, Tammie
Bernert, Richard
Elston, Dirk M.
TI Microphthalmia-Associated Transcription Factor-Positive Pseudonests in
Cutaneous Lupus Erythematosus
SO AMERICAN JOURNAL OF DERMATOPATHOLOGY
LA English
DT Letter
ID MELANOMA IN-SITU; SUN-DAMAGED SKIN; IMMUNOHISTOCHEMICAL DEMONSTRATION;
PSEUDOMELANOCYTIC NESTS; KERATOSIS; PROTEIN; NEVI
C1 [Abuzeid, Margaret] Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA.
[Abuzeid, Margaret] Wilford Hall USAF Med Ctr, San Antonio, TX USA.
[Dalton, Scott R.; Ferringer, Tammie; Elston, Dirk M.] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA.
[Bernert, Richard] Arizona Dermatopathol, Scottsdale, AZ USA.
RP Abuzeid, M (reprint author), Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA.
NR 10
TC 3
Z9 3
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0193-1091
J9 AM J DERMATOPATH
JI Am. J. Dermatopathol.
PD OCT
PY 2011
VL 33
IS 7
BP 752
EP 754
DI 10.1097/DAD.0b013e3182099476
PG 4
WC Dermatology
SC Dermatology
GA 823JP
UT WOS:000295118600024
PM 21915039
ER
PT J
AU Li, B
Mahan, CM
Kang, HK
Eisen, SA
Engel, CC
AF Li, Bo
Mahan, Clare M.
Kang, Han K.
Eisen, Seth A.
Engel, Charles C.
TI Longitudinal Health Study of US 1991 Gulf War Veterans: Changes in
Health Status at 10-Year Follow-up
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Gulf War; health status; incidence; longitudinal studies; risk; stress
disorders; post-traumatic; veterans
ID POSTTRAUMATIC-STRESS-DISORDER; POPULATION-BASED SURVEY; PSYCHOMETRIC
PROPERTIES; PTSD CHECKLIST; I VETERANS; ILLNESS; COUNTERPOINT; DISEASE;
COHORT
AB The authors assessed changes in the health status of US 1991 Gulf War-era veterans from a 1995 baseline survey to a 2005 follow-up survey, using repeated measurement data from 5,469 deployed Gulf War veterans and 3,353 nondeployed Gulf War-era veterans who participated in both surveys. Prevalence differences in health status between the 2 surveys were estimated for adverse health indices and chronic diseases for each veteran group. Persistence risk ratios and incidence risk ratios were calculated after adjustment for demographic and military service characteristics through Mantel-Haenszel stratified analysis. At 10-year follow-up, deployed veterans were more likely to report persistent poor health, as measured by the health indices (functional impairment, limitation of activities, repeated clinic visits, recurrent hospitalizations, perception of health as fair or poor, chronic fatigue syndrome-like illness, and posttraumatic stress disorder), than nondeployed veterans. Additionally, deployed veterans were more likely to experience new onset of adverse health (as measured by the indices) and certain chronic diseases than were nondeployed veterans. During the 10-year period from 1995 to 2005, the health of deployed veterans worsened in comparison with nondeployed veterans because of a higher rate of new onset of various health outcomes and greater persistence of previously reported adverse health on the indices.
C1 [Li, Bo] Dept Vet Affairs, Washington DC VA Med Ctr, Inst Clin Res Inc, Washington, DC USA.
[Mahan, Clare M.; Kang, Han K.] Dept Vet Affairs, Off Publ Hlth, Environm Epidemiol Serv, Washington, DC USA.
[Eisen, Seth A.] Dept Vet Affairs, Hlth Serv Res & Dev Serv, Washington, DC USA.
[Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Engel, Charles C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA.
RP Kang, HK (reprint author), Dept Vet Affairs, Environm Epidemiol Serv 10P3A, 810 Vermont Ave NW, Washington, DC 20420 USA.
EM han.kang@va.gov
RI Schueter, nicos/A-3625-2014
FU Department of Defense [DAMD 17-02-1-0200]; Department of Veterans
Affairs
FX This work was supported by the Department of Defense under contract DAMD
17-02-1-0200 and by the Department of Veterans Affairs.
NR 34
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U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD OCT 1
PY 2011
VL 174
IS 7
BP 761
EP 768
DI 10.1093/aje/kwr154
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 823ZC
UT WOS:000295166500002
PM 21795757
ER
PT J
AU Knapik, JJ
Graham, B
Steelman, R
Colliver, K
Jones, BH
AF Knapik, Joseph J.
Graham, Bria
Steelman, Ryan
Colliver, Keith
Jones, Bruce H.
TI The Advanced Tactical Parachute System (T-11): Injuries During Basic
Military Parachute Training
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE T-10 parachute; entanglements; wind speed; parachute ankle brace
ID ANKLE INJURIES; JUMPS; SCHOOL; BRACE
AB KNAPIK JJ GRAHAM B, STEELMAN R, COLLIVER K, JONES BH. The Advanced Tactical Parachute System (T-11): injuries during basic military parachute training. Aviat Space Environ Med 2011; 82:935-40.
Background: Since the 1950;, the standard U.S. military troop parachute system has been the T-10. The T-10 is currently being replaced by the newer T-11 system. Purpose: This investigation compared injury incidence between the T-10 and T-11 military parachute systems. Methods: Participants were students in basic parachute training at the U.S. Army Airborne School (USAAS). Students performed their first parachute jumps with the T-11 and subsequent jumps with the T-10. Injury data were collected from routine reports produced by the USAAS. Combat loaded jumps and night jumps were excluded from the analysis since these were only conducted with the T-10. Results: There were a total of 76 injuries in 30,755 jumps for ar overall cumulative injury incidence of 2.5/1000 jumps. With the T-10 parachute, there were 61 injuries in 21,404 jumps for a cumulative injury incidence of 2.9/1000 jumps; with the T-11 parachute there were 15 injuries in 9351 jumps for a cumulative injury incidence of 1.6/1000 jumps [risk ratio (T10/T-11) = 1.78, 95% confidence interval = 1.01-3.12, P = 0.04]. Discussion: Limitations to this analysis included the fact that the T-11 was only used on the first jumps among students who had likely never previously performed a parachute jump and that aircraft exit procedures differed very slightly for the two parachutes. Nonetheless, the data suggest that injury incidence is lower with the T-11 parachute film with the T-10 parachute when airborne training operations are conducted during the clay without combat loads.
C1 [Knapik, Joseph J.] USA, ATTN MCHB IP DI, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
[Colliver, Keith] Engility Corp, Personnel Airdrop Syst, Soldier Clothing & Individual Equipment, Ft Belvoir, VA USA.
RP Knapik, JJ (reprint author), USA, ATTN MCHB IP DI, Inst Publ Hlth, Bldg 1570,5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM joseph.knapik@us.army.mil
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PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD OCT
PY 2011
VL 82
IS 10
BP 935
EP 940
DI 10.3357/ASEM.3082.2011
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA 824FE
UT WOS:000295187000001
PM 21961396
ER
PT J
AU Gaydos, S
Almond, N
AF Gaydos, Steven
Almond, Nathaniel
TI Public Health from Space?
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Editorial Material
C1 [Gaydos, Steven] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA.
[Almond, Nathaniel] USN, Aerosp Med Inst, Pensacola, FL USA.
RP Gaydos, S (reprint author), USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA.
OI almond, nathaniel/0000-0002-7937-0340
NR 12
TC 0
Z9 0
U1 1
U2 4
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD OCT
PY 2011
VL 82
IS 10
BP 1000
EP 1001
DI 10.3357/ASEM.3118.2011
PG 2
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA 824FE
UT WOS:000295187000013
PM 21961407
ER
PT J
AU Hwang, WR
Advani, SG
Walsh, S
AF Hwang, Wook Ryol
Advani, Suresh G.
Walsh, Shawn
TI Direct simulations of particle deposition and filtration in dual-scale
porous media
SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
LA English
DT Article
DE Particle-reinforcement; Rheological properties; Computational modeling;
Resin transfer molding (RTM)
ID BI-PERIODIC FRAMES; IMPREGNATION; SUSPENSIONS; COMPOSITES; MECHANISMS;
FLOWS
AB A two dimensional direct numerical simulation technique is developed to describe particulate flows in dual-scale porous media to predict particle deposition on the permeable porous surface in liquid composite molding processes. This individual particle level simulation accounts for hydrodynamic interaction between particles and the fluid, especially near a porous wall (fiber tow), and can predict the deposition of the particles on solid or porous surfaces. A Stokes-Brinkman coupling is employed to describe the flow in dual-scale porous media and a fictitious domain approach is used to deal with freely suspended particles in the fluid stream. A single particle deposition process is investigated extensively along with effects of the permeability of porous media, the particle size and the pressure drop. Mechanisms leading to accelerated or delayed deposition of particles are analyzed by investigating the velocity fields around the particle in close proximity of the porous surface. Finally, particle filtration simulation are performed with a large number of particles to demonstrate the feasibility of this scheme to address particle deposition and filtration during manufacturing of composites using liquid composite molding processes in which the particles are mixed with the resin and the suspension is injected into a stationary dual scale preform. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Advani, Suresh G.] Univ Delaware, Dept Mech Engn, Ctr Composite Mat, Newark, DE 19716 USA.
[Hwang, Wook Ryol] Gyeongsang Natl Univ, Sch Mech Engn, ReCAPT, Jinju 660701, South Korea.
[Walsh, Shawn] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Advani, SG (reprint author), Univ Delaware, Dept Mech Engn, Ctr Composite Mat, Newark, DE 19716 USA.
EM advani@udel.edu
FU National Research Foundation (NRF) of Korea; Ministry of Education.
Science and Technology [2009-0094015, 2010-0021614]; Army Research
Laboratory [W911NF-06-2-011]
FX This work was supported by the National Research Foundation (NRF) of
Korea funded by the Ministry of Education. Science and Technology
(2009-0094015 and 2010-0021614) and by the Army Research Laboratory
(Grant Number W911NF-06-2-011).
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U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-835X
J9 COMPOS PART A-APPL S
JI Compos. Pt. A-Appl. Sci. Manuf.
PD OCT
PY 2011
VL 42
IS 10
BP 1344
EP 1352
DI 10.1016/j.compositesa.2011.05.017
PG 9
WC Engineering, Manufacturing; Materials Science, Composites
SC Engineering; Materials Science
GA 824ZS
UT WOS:000295241300007
ER
PT J
AU Pankow, M
Salvi, A
Waas, AM
Yen, CF
Ghiorse, S
AF Pankow, M.
Salvi, A.
Waas, A. M.
Yen, C. F.
Ghiorse, S.
TI Resistance to delamination of 3D woven textile composites evaluated
using End Notch Flexure (ENF) tests: Experimental results
SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
LA English
DT Article
DE 3-Dimensional reinforcement; Fracture; Fracture toughness; Impact
behavior
ID FRACTURE; IMPACT; FABRICATION; DESIGN; EPOXY
AB The flexural response of 3D woven textile composite panels containing an edge crack is evaluated using the End Notch Flexure (ENF) test. In doing so, the effectiveness of 3D reinforcement in increasing and/or eliminating delamination is demonstrated. Two types of textile architectures, referred to as Z-fiber reinforcement and a layer-to-layer architecture were examined. At quasi-static and low rate; 0.01 mm/Section (0.0004 in/s) and 50.8 mm/Section (2 in/s), results showed that the Z-fiber reinforcement provided a higher strength, although the layer-to-layer reinforcement provided more energy absorption and prevented mode II crack propagation, thus providing insight into eliminating the delamination mode of failure. At higher loading rates, using an instrumented drop tower at impactor velocities of 2.79 m/Section (110 in/s) and 3.96 m/Section (156 in/s), results suggested a rate dependent mode II strength of the material. Computational models to further explore the experimental results are presented in a follow-on paper in this issue of the journal [1]. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Pankow, M.; Salvi, A.; Waas, A. M.] Univ Michigan, Composite Struct Lab, Dept Aerosp Engn, Ann Arbor, MI 48109 USA.
[Yen, C. F.; Ghiorse, S.] USA, Res Labs, Aberdeen, MD USA.
RP Waas, AM (reprint author), Univ Michigan, Composite Struct Lab, Dept Aerosp Engn, 1320 Beal St, Ann Arbor, MI 48109 USA.
EM dcw@umich.edu
FU Army Research Laboratory, Aberdeen proving ground, MD
FX The authors thank the Army Research Laboratory, Aberdeen proving ground,
MD, for their continued financial support.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-835X
J9 COMPOS PART A-APPL S
JI Compos. Pt. A-Appl. Sci. Manuf.
PD OCT
PY 2011
VL 42
IS 10
BP 1463
EP 1476
DI 10.1016/j.compositesa.2011.06.013
PG 14
WC Engineering, Manufacturing; Materials Science, Composites
SC Engineering; Materials Science
GA 824ZS
UT WOS:000295241300021
ER
PT J
AU Athrey, G
Lindsay, DL
Lance, RF
Leberg, PL
AF Athrey, Giridhar
Lindsay, Denise L.
Lance, Richard F.
Leberg, Paul L.
TI Crumbling diversity: comparison of historical archived and contemporary
natural populations indicate reduced genetic diversity and increasing
genetic differentiation in the golden-cheeked warbler
SO CONSERVATION GENETICS
LA English
DT Article
DE Genetic diversity; Fragmentation; Effective population size; Endangered
birds; Historical-contemporary samples
ID CAPERCAILLIE TETRAO-UROGALLUS; HABITAT FRAGMENTATION; CONSERVATION
GENETICS; GENOTYPING ERRORS; TEMPORAL-CHANGES; NEST SURVIVAL; SIZE;
DISPERSAL; CONSEQUENCES; BOTTLENECKS
AB Genetic viability of threatened and endangered species is of increasing concern with habitat loss and fragmentation. Valuable assessments of the genetic status of endangered species are difficult in most cases, where only single sample estimates are available. Using historical and contemporary samples, we assessed the impact of both historical and recent demographic changes on population genetics of the endangered golden-cheeked warbler, (Dendroica chrysoparia). Our study documents a steep decline in genetic diversity in an endangered species over a 100-year period, along with concurrent increase in genetic differentiation, and low contemporary effective sizes for all the populations we evaluated. While adding to the growing body of literature that describes the genetic impacts of habitat fragmentation, our study may also serve as an informative guide to future management of endangered species. Our study underlines the importance of long term population genetic monitoring in understanding the full extent of genetic changes in endangered species.
C1 [Athrey, Giridhar; Leberg, Paul L.] Univ SW Louisiana, Dept Biol, Lafayette, LA 70504 USA.
[Lindsay, Denise L.; Lance, Richard F.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Athrey, Giridhar] Texas A&M Univ, Vector Biol Grp, College Stn, TX 77843 USA.
RP Athrey, G (reprint author), Univ SW Louisiana, Dept Biol, POB 42451, Lafayette, LA 70504 USA.
EM giri.athrey@tamu.edu
RI Athrey, Giridhar/H-4077-2011
OI Athrey, Giridhar/0000-0002-7396-5490
FU U.S. Department of Defense; U.S. Army
FX We thank the AMNH, New York, NY, MCZ Harvard University, Cambridge, MA,
FMNH, Chicago, IL, and NMNH, Washington DC for tissue samples. We thank
Ft. Hood, Kerr WMA, Balcones Canyonlands NWR, TPWD, K. Barr, C. Goates,
J. Hernandez, S. Pathikonda, and L. Butler for access to field sites,
and help with field sampling. We thank J. Neigel, S. Mopper and D.
Johnson and anonymous reviewers for comments on an earlier version of
this manuscript. This study was funded by U.S. Department of Defense
under the Section 6.1 Basic Research Program and U.S. Army 6.2
Threatened and Endangered Species Program to RFL and PLL.
NR 53
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1566-0621
J9 CONSERV GENET
JI Conserv. Genet.
PD OCT
PY 2011
VL 12
IS 5
BP 1345
EP 1355
DI 10.1007/s10592-011-0235-8
PG 11
WC Biodiversity Conservation; Genetics & Heredity
SC Biodiversity & Conservation; Genetics & Heredity
GA 819BE
UT WOS:000294799600018
ER
PT J
AU Oliver, KE
Enewold, LR
Zhu, KM
Conrads, TP
Rose, GS
Maxwell, GL
Farley, JH
AF Oliver, Kate E.
Enewold, Lindsey R.
Zhu, Kangmin
Conrads, Thomas P.
Rose, G. Scott
Maxwell, G. Larry
Farley, John H.
TI Racial disparities in histopathologic characteristics of uterine cancer
are present in older, not younger blacks in an equal-access environment
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE Uterine cancer; Racial; Disparity; Age
ID GYNECOLOGIC-ONCOLOGY-GROUP; ENDOMETRIAL CANCER; AFRICAN-AMERICAN; WHITE
WOMEN; RACIAL/ETHNIC DIFFERENCES; REPLACEMENT THERAPY; CYTOCHROME-P450
1B1; PROGNOSTIC-FACTORS; CARCINOMA; SURVIVAL
AB Objective. We sought to determine whether racial disparities in tumor characteristics among uterine cancer patients persisted, and varied by age, in an equal-access healthcare population.
Methods. The distributions of tumor histology, stage and grade by race were compared for uterine cancers diagnosed from 1990 to 2003 using data from the U.S. Department of Defense's Automated Central Tumor Registry. Comparisons were conducted overall and stratified by age (<50, >= 50) using the Chi-square test.
Results. Of 2582 uterine tumors identified, 2057 (79.7%) were diagnosed among White women and 183 (7.1%) among Black women. Among all women analyzed, Blacks were more likely than Whites to present with non-endometrioid tumors (47.7% vs 23.5%, p < 0.01), non-localized tumors (31.8% vs 24.5%, p = 0.02), and poorly differentiated tumors (20.5% vs 15.0%, p<0.01). Among women 50 years and older, similar significant racial disparities were observed. However, no significant racial differences were observed among young patients. When comparisons were restricted to endometrioid histology adenocarcinomas, trends in age-specific disparities for older women were observed.
Conclusions. Our study suggests that racial disparities in uterine cancers persist between Blacks and Whites in an equal-access population. Blacks endure higher stage and grade tumors, and more aggressive histologies. This disparity in clinicopathologic factors is confined to women older than 50 years. Multiple factors such as racial variation in age-related health knowledge/behavior and estrogen metabolism may be related to the racial disparity. Published by Elsevier Inc.
C1 [Farley, John H.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA.
[Oliver, Kate E.; Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA.
[Enewold, Lindsey R.; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
[Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Conrads, Thomas P.] Womens Hlth Integrated Res Ctr Inova Hlth Syst, Gynecol Canc Ctr Excellence, Annandale, VA 22003 USA.
RP Farley, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM john.farley@us.army.mil
RI Oliver, Kate/H-7599-2014
OI Oliver, Kate/0000-0002-0595-9080
NR 50
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U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD OCT
PY 2011
VL 123
IS 1
BP 76
EP 81
DI 10.1016/j.ygyno.2011.06.027
PG 6
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 824NL
UT WOS:000295208500015
PM 21741078
ER
PT J
AU Isaacson, BM
Stinstra, JG
Bloebaum, RD
Pasquina, PF
MacLeod, RS
AF Isaacson, Brad M.
Stinstra, Jeroen G.
Bloebaum, Roy D.
Pasquina, Paul F.
MacLeod, Rob S.
TI Establishing Multiscale Models for Simulating Whole Limb Estimates of
Electric Fields for Osseointegrated Implants
SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
LA English
DT Article
DE Biomedical electrodes; electrical stimulation; finite element analysis
(FEA); osseointegration; skeletal attachment
ID HETEROTOPIC OSSIFICATION; BONE
AB Although the survival rates of warfighters in recent conflicts are among the highest in military history, those who have sustained proximal limb amputations may present additional rehabilitation challenges. In some of these cases, traditional prosthetic limbs may not provide adequate function for service members returning to an active lifestyle. Osseointegration has emerged as an acknowledged treatment for those with limited residual limb length and those with skin issues associated with a socket together. Using this technology, direct skeletal attachment occurs between a transcutaneous osseointegrated implant (TOI) and the host bone, thereby eliminating the need for a socket. While reports from the first 100 patients with a TOI have been promising, some rehabilitation regimens require 1218 months of restricted weight bearing to prevent overloading at the bone-implant interface. Electrically induced osseointegration has been proposed as an option for expediting periprosthetic fixation and preliminary studies have demonstrated the feasibility of adapting the TOI into a functional cathode. To assure safe and effective electric fields that are conducive for osseoinduction and osseointegration, we have developed multiscale modeling approaches to simulate the expected electric metrics at the bone-implant interface. We have used computed tomography scans and volume segmentation tools to create anatomically accurate models that clearly distinguish tissue parameters and serve as the basis for finite element analysis. This translational computational biological process has supported biomedical electrode design, implant placement, and experiments to date have demonstrated the clinical feasibility of electrically induced osseointegration.
C1 [Isaacson, Brad M.] Henry M Jackson Fdn Advancement Mil Med Inc, Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Stinstra, Jeroen G.; MacLeod, Rob S.] Univ Utah, Sci Comp & Imagining Inst, Salt Lake City, UT 84112 USA.
[Bloebaum, Roy D.] Dept Vet Affairs, Salt Lake City, UT 84148 USA.
[Bloebaum, Roy D.] Univ Utah, Dept Orthopaed, Salt Lake City, UT 84112 USA.
[Bloebaum, Roy D.; MacLeod, Rob S.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
[Bloebaum, Roy D.] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA.
[Pasquina, Paul F.] US Dept Army, Washington, DC 20307 USA.
[Pasquina, Paul F.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
[Pasquina, Paul F.] Natl Naval Med Ctr, Bethesda, MD 20889 USA.
[MacLeod, Rob S.] Nora Eccles Harrison Cardiovasc Res & Training In, Salt Lake City, UT 84112 USA.
[MacLeod, Rob S.] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.
RP Isaacson, BM (reprint author), Henry M Jackson Fdn Advancement Mil Med Inc, Walter Reed Army Med Ctr, Washington, DC 20307 USA.
EM bmisaacson@gmail.com; jstinstra@numirabio.com;
roy.bloebaum@hsc.utah.edu; paul.pasquina@us.army.mil;
macleod@cvrti.utah.edu
FU Veterans Affairs Office of Research and Development, Rehabilitation R&D
Service, DVA SLC Health Care System, Salt Lake City, UT; Albert and
Margaret Hofmann Chair; Department of Orthopaedics, University of Utah
School of Medicine, Salt Lake City, UT; Technology Commercialization
Office, University of Utah, Salt Lake City, UT; Department of the U.S.
Army [W81XWH-06-2-0073]; Department of Defense Health Programs' Center
for Rehabilitation Sciences Research [NF90UG]; NIH/NCRR Center for
Integrative Biomedical Computing [P41-RR12553-07]
FX Manuscript received March 24, 2011; revised April 28, 2011 and May 21,
2011; accepted June 7, 2011. Date of publication June 27, 2011; date of
current version September 21, 2011. This work was supported in part by
the Veterans Affairs Office of Research and Development, Rehabilitation
R&D Service, DVA SLC Health Care System, Salt Lake City, UT; the Albert
and Margaret Hofmann Chair and the Department of Orthopaedics,
University of Utah School of Medicine, Salt Lake City, UT; the
Technology Commercialization Office, University of Utah, Salt Lake City,
UT; the Department of the U.S. Army under Award W81XWH-06-2-0073 to the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. Washington D.C.; the Department of Defense Health Programs' Center
for Rehabilitation Sciences Research, NF90UG. Technical support for the
simulations was provided by the Center for Integrative Biomedical
Computing of Scientific Computing and Imaging Institute and made
possible in part by software from the NIH/NCRR Center for Integrative
Biomedical Computing under Grant P41-RR12553-07. Asterisk indicates
corresponding author.
NR 17
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PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9294
J9 IEEE T BIO-MED ENG
JI IEEE Trans. Biomed. Eng.
PD OCT
PY 2011
VL 58
IS 10
BP 2991
EP 2994
DI 10.1109/TBME.2011.2160722
PN 2
PG 4
WC Engineering, Biomedical
SC Engineering
GA 823DN
UT WOS:000295102600014
PM 21712151
ER
PT J
AU Kissner, TL
Ruthel, G
Cisney, ED
Ulrich, RG
Fernandez, S
Saikh, KU
AF Kissner, Teri L.
Ruthel, Gordon
Cisney, Emily D.
Ulrich, Robert G.
Fernandez, Stefan
Saikh, Kamal U.
TI MyD88-dependent pro-inflammatory cytokine response contributes to lethal
toxicity of staphylococcal enterotoxin B in mice
SO INNATE IMMUNITY
LA English
DT Article
DE TLR; MyD88; NF-kappa B; staphylococcal enterotoxin B; cytokine
ID TOLL-LIKE RECEPTOR; TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B; CLASS-II;
SIGNAL-TRANSDUCTION; HUMAN-MONOCYTES; HLA-DR; MYD88-DEFICIENT MICE;
MYD88-LIKE ADAPTERS; TYROSINE KINASE
AB An elevated pro-inflammatory cytokine response is the primary cause of death by toxic shock after exposure to staphylococcal enterotoxin B (SEB). Identifying an intracellular signal mediator that predominantly controls the pro-inflammatory response is important for developing a therapeutic strategy. We examined the role of the signaling adaptor MyD88 in cell culture and in a mouse model of toxic shock. Our results indicated that elevated tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-1 alpha/beta and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was regulated by MyD88. Elevated levels of MyD88 protein in spleen cells, as well as in CD11c(+) or Mac3(+) cells, and activation of nuclear factor-kappa B in spleen cells were observed in mice treated with SEB. An SEB-dose dependent lethality was observed in LPS-potentiated and in D-galactosamine-sensitized mice. D-Galactosamine treatment of spleen cells had no effect in cytokine induction but rather increased the sensitivity to toxic shock in mice. Our results demonstrated an impaired pro-inflammatory cytokine production by spleen cells of MyD88(-/-) mice in response to SEB or SEB plus LPS. Most importantly, MyD88(-/-) mice were resistant to SEB-induced death. These results demonstrate that MyD88-dependent pro-inflammatory signaling is responsible for SEB intoxication. In addition, our studies also demonstrated that LPS potentiation, in comparison to D-galactosamine sensitization, contributes to a stronger SEB-induced lethality. This is due to the pro-inflammatory cytokine response elicited by MyD88 after exposure to SEB and LPS. These findings offer an important insight upon SEB intoxication and subsequent therapy targeting MyD88.
C1 [Kissner, Teri L.; Ruthel, Gordon; Cisney, Emily D.; Ulrich, Robert G.; Fernandez, Stefan; Saikh, Kamal U.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA.
RP Saikh, KU (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, 1425 Porter St, Frederick, MD 21702 USA.
EM kamal.saikh@amedd.army.mil
FU Defense Threat Reduction Agency
FX This work was funded by the Defense Threat Reduction Agency (KUS).
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1753-4259
J9 INNATE IMMUN-LONDON
JI Innate Immun.
PD OCT
PY 2011
VL 17
IS 5
BP 451
EP 462
DI 10.1177/1753425910374092
PG 12
WC Biochemistry & Molecular Biology; Immunology; Medicine, Research &
Experimental; Microbiology
SC Biochemistry & Molecular Biology; Immunology; Research & Experimental
Medicine; Microbiology
GA 824QF
UT WOS:000295216300003
PM 20699281
ER
PT J
AU Mayhew, JL
Brechue, WF
Smith, AE
Kemmler, W
Lauber, D
Koch, AJ
AF Mayhew, Jerry L.
Brechue, William F.
Smith, Abbie E.
Kemmler, Wolfgang
Lauber, Dirk
Koch, Alexander J.
TI IMPACT OF TESTING STRATEGY ON EXPRESSION OF UPPER-BODY WORK CAPACITY AND
ONE-REPETITION MAXIMUM PREDICTION AFTER RESISTANCE TRAINING IN
COLLEGE-AGED MEN AND WOMEN
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE linear periodization; gender difference; bench press; muscular
endurance; strength prediction
ID UNDULATING PERIODIZED PROGRAMS; LOCAL MUSCULAR ENDURANCE; BENCH PRESS;
GENERALIZED EQUATIONS; FOOTBALL PLAYERS; EQUATED VOLUME; STRENGTH;
EXERCISE; INTENSITY; ADAPTATIONS
AB Mayhew, JL, Brechue, WF, Smith, AE, Kemmler, W, Lauber, D, and Koch, AJ. Impact of testing strategy on expression of upper-body work capacity and one repetition maximum prediction after resistance training in college-aged men and women. J Strength Cond Res 25(10): 2796-2807, 2011-The purpose of this study was to assess the effect of resistance training on upper-body muscular strength and the expression of work capacity and muscular endurance. In addition, a training-induced change in the relationship between muscular strength and endurance was assessed by testing changes in the accuracy of using endurance repetitions to predict 1 repetition maximum (1RM) bench press before and after training. College-aged men (n = 85) and women (n = 62) completed a 12-week linear periodization resistance training program. Before and after training, the subjects were assessed for 1RM and repetitions to fatigue (RTFs) with a submaximal load. After pretraining 1RM determination, the subjects were randomly assigned to perform RTFs at 65% 1RM (n = 74) or 90% 1RM (n = 73). Pretraining and posttraining RTFs were conducted at the same respective % 1RM. Work capacity was determined from repetition weight x RTF. After training, there was a significant increase in 1RM in both men (similar to 14%) and women (similar to 23%). Posttraining RTF was not different from pretraining RTF at 65 % 1RM (18.2 +/- 5.1 and 19.0 +/- 6.0, respectively) but was significantly reduced in the 90% 1RM group (6.1 +/- 3.6 vs. 4.5 +/- 2.7, respectively). Likewise, there was a differential effect of training on the expression of work capacity, which increased in the 65 % 1RM group (123 +/- 155 kg-reps) but decreased in the 90% 1RM group (262 +/- 208 kg-reps); the effect was independent of gender within each testing group. In conclusion, the changes in muscular strength associated with resistance training produced an increase in work capacity when tested with a 65 % 1RM load without a change in endurance. In contrast, both work capacity and endurance decreased when tested with 90% 1RM. Thus, the impact of strength training on work capacity and muscle endurance is specific to the load at which endurance testing is performed.
C1 [Mayhew, Jerry L.; Koch, Alexander J.] Truman State Univ, Human Performance Lab, Kirksville, MO USA.
[Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA.
[Brechue, William F.] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA.
[Smith, Abbie E.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC USA.
[Kemmler, Wolfgang; Lauber, Dirk] Univ Erlangen Nurnberg, Inst Med Phys, Erlangen, Germany.
[Koch, Alexander J.] Lenoir Rhyne Univ, Hlth Exercise & Sports Sci Dept, Hickory, NC USA.
RP Mayhew, JL (reprint author), Truman State Univ, Human Performance Lab, Kirksville, MO USA.
EM jmayhew@truman.edu
OI Smith-Ryan, Abbie/0000-0002-5405-304X
NR 41
TC 3
Z9 3
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD OCT
PY 2011
VL 25
IS 10
BP 2796
EP 2807
DI 10.1519/JSC.0b013e31822dcea0
PG 12
WC Sport Sciences
SC Sport Sciences
GA 823YA
UT WOS:000295162700022
PM 21904231
ER
PT J
AU Reed, DS
Lackemeyer, MG
Garza, NL
Sullivan, LJ
Nichols, DK
AF Reed, Douglas S.
Lackemeyer, Matthew G.
Garza, Nicole L.
Sullivan, Lawrence J.
Nichols, Donald K.
TI Aerosol exposure to Zaire ebolavirus in three nonhuman primate species:
differences in disease course and clinical pathology
SO MICROBES AND INFECTION
LA English
DT Article
DE Ebola; Nonhuman primate; Aerosol
ID ATTENUATED RECOMBINANT VACCINE; EQUINE ENCEPHALITIS-VIRUS;
HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; MARBURG VIRUSES; RHESUS-MONKEYS;
GUINEA-PIGS; INFECTION; PROTECTION; TRANSMISSION
AB There is little known concerning the disease caused by Zaire ebolavirus (ZEBOV) when inhaled, the likely route of exposure in a biological attack. Cynomolgus macaques, rhesus macaques, and African green monkeys were exposed to aerosolized ZEBOV to determine which species might be the most relevant model of the human disease. A petechial rash was noted on cynomolgus and rhesus macaques after fever onset but not on African green monkeys. Fever duration was shortest in rhesus macaques (62.7 +/- 16.3 h) and longest in cynomolgus macaques (82.7 +/- 22.3 h) and African green monkeys (88.4 +/- 16.7 h). Virus was first detectable in the blood 3 days after challenge; the level of viremia was comparable among all three species. Hematological changes were noted in all three species, including decreases in lymphocyte and platelet counts. Increased blood coagulation times were most pronounced in African green monkeys. Clinical signs and time to death in all three species were comparable to what has been reported previously for each species after parenteral inoculation with ZEBOV. These data will be useful in selection of an animal model for efficacy studies. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
C1 [Reed, Douglas S.; Lackemeyer, Matthew G.; Garza, Nicole L.; Sullivan, Lawrence J.; Nichols, Donald K.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
RP Reed, DS (reprint author), Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15260 USA.
EM dsreed@cvr.pitt.edu
OI Reed, Douglas/0000-0003-0076-9023
FU Defense Threat Reduction Agency [XX0009 06 RD B]
FX The authors acknowledge that this work was supported by funding from the
Defense Threat Reduction Agency, Project # XX0009 06 RD B. The authors
also acknowledge Carlton Rice for taking care of the NHP used in these
studies; the technicians and veterinarians of the Veterinary Medicine
Division at USAMRIID for implantation of the telemetry devices,
collection of blood samples, and administration of euthanasia; Jason
Buck for his assistance in running CBC samples; Adam Hedge and Ty Hunter
for their assistance in the aerosol exposures; and Dr. Lisa Hensley, Dr.
Thomas Geisbert and Mrs. Joan Geisbert for providing the challenge
virus. The views, opinions, and/or findings contained herein are those
of the authors and should not be construed as an official Department of
Army position, policy, or decision unless so designated by other
documentation.
NR 27
TC 39
Z9 39
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1286-4579
J9 MICROBES INFECT
JI Microbes Infect.
PD OCT
PY 2011
VL 13
IS 11
BP 930
EP 936
DI 10.1016/j.micinf.2011.05.002
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 824IQ
UT WOS:000295196000007
PM 21651988
ER
PT J
AU Matthes, K
Thakkar, SJ
Lee, SH
Gromski, MA
Lim, RB
Janschek, J
Jones, SB
Jones, DB
Chuttani, R
AF Matthes, Kai
Thakkar, Shyam J.
Lee, Suck-Ho
Gromski, Mark A.
Lim, Robert B.
Janschek, Johannes
Jones, Stephanie B.
Jones, Daniel B.
Chuttani, Ram
TI Development of a pancreatic tumor animal model and evaluation of NOTES
tumor enucleation
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE NOTES; Pancreatic tumor enucleation; Pancreas
ID PORCINE MODEL; DISTAL PANCREATECTOMY; SURGERY; CHOLECYSTECTOMY;
FEASIBILITY; NEPHRECTOMY; RESECTIONS; INJECTION; NEOPLASMS; SURVIVAL
AB Background Laparoscopic distal pancreatectomy is associated with high morbidity and mortality. NOTES tumor enucleation may provide an alternative to laparoscopic distal pancreatectomy. The goal of this study was to determine the feasibility of NOTES tumor creation and enucleation as a multidisciplinary approach.
Methods A linear-array endoscopic ultrasound (EUS) endoscope was used to inject a thermosensitive ABA triblock polymer mixed with methylene blue through the stomach wall and into the distal pancreas using a 22-gauge EUS needle. Due to its thermosensitive character, the polymer solidifies in response to body temperature, creating an artificial tumor. Seventeen swine underwent NOTES transgastric pancreatic tumor enucleation. Nine nonsurvival animals were sacrificed immediately after the NOTES procedure, with subsequent necropsy. Eight survival animals were observed for up to 16 days after the procedure, subsequently sacrificed, followed by necropsy.
Results The procedure was performed successfully in all 17 pigs studied, 9/9 nonsurvival (100%) and 8/8 survival (100%) animals, using a pure NOTES approach without any laparoscopic ports. Complications included two esophageal dissections (1 in nonsurvival group, 1 in survival group) caused by the introduction of the endoscopic overtube (2/17, 12%), unrelated to the actual surgical procedure. In the survival animals, there were two small splenic lacerations caused during retraction with the endoscopic forceps, for which hemostasis was achieved prior to closure of the gastrotomy (2/7, 29%). At necropsy of the animals, there was sufficient closure of 15/17 gastrotomy sites (88%).
Conclusions The creation of artificial pancreatic tumors via EUS guidance is feasible. Pancreatic tumor enucleation using a transgastric NOTES approach is technically feasible and could be an alternative to laparoscopic distal pancreatectomy with further development. Further adoption and adaptation of this technique will require the development of more sophisticated specialized tools to improve the safety profile of the procedure.
C1 [Matthes, Kai; Gromski, Mark A.; Chuttani, Ram] Harvard Univ, Div Gastroenterol, Dept Med, Beth Israel Deaconess Med Ctr,Med Sch, Boston, MA 02215 USA.
[Matthes, Kai] Harvard Univ, Dept Anesthesiol Perioperat & Pain Med, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USA.
[Thakkar, Shyam J.] Drexel Univ, Div Gastroenterol, Dept Med, Coll Med, Pittsburgh, PA 15212 USA.
[Lee, Suck-Ho] Soon Chun Hyang Univ, Div Gastroenterol, Dept Med, Coll Med, Cheonan, South Korea.
[Lim, Robert B.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Janschek, Johannes] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany.
[Jones, Stephanie B.] Harvard Univ, Dept Anesthesia Crit Care & Pain Med, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
[Jones, Daniel B.] Harvard Univ, Dept Surg, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
RP Matthes, K (reprint author), Harvard Univ, Div Gastroenterol, Dept Med, Beth Israel Deaconess Med Ctr,Med Sch, 330 Brookline Ave,Dana 501, Boston, MA 02215 USA.
EM kmatthes@bidmc.harvard.edu
OI Jones, Stephanie/0000-0001-8342-0374
NR 28
TC 5
Z9 5
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
J9 SURG ENDOSC
JI Surg. Endosc.
PD OCT
PY 2011
VL 25
IS 10
BP 3191
EP 3197
DI 10.1007/s00464-011-1686-1
PG 7
WC Surgery
SC Surgery
GA 821HB
UT WOS:000294964600009
PM 21487862
ER
PT J
AU Hancock, PA
Billings, DR
Schaefer, KE
Chen, JYC
de Visser, EJ
Parasuraman, R
AF Hancock, Peter A.
Billings, Deborah R.
Schaefer, Kristin E.
Chen, Jessie Y. C.
de Visser, Ewart J.
Parasuraman, Raja
TI A Meta-Analysis of Factors Affecting Trust in Human-Robot Interaction
SO HUMAN FACTORS
LA English
DT Article
DE trust; trust development; robotics; human-robot team
ID AUTOMATION; PERFORMANCE; INTERFACE; WORKLOAD; RELIANCE; ISSUES; TASK;
HOME
AB Objective: We evaluate and quantify the effects of human, robot, and environmental factors on perceived trust in human-robot interaction (HRI).
Background: To date, reviews of trust in HRI have been qualitative or descriptive. Our quantitative review provides a fundamental empirical foundation to advance both theory and practice.
Method: Meta-analytic methods were applied to the available literature on trust and HRI. A total of 29 empirical studies were collected, of which 10 met the selection criteria for correlational analysis and 11 for experimental analysis. These studies provided 69 correlational and 47 experimental effect sizes.
Results: The overall correlational effect size for trust was (r) over bar=+0.26, with an experimental effect size of (d) over bar=+0.71. The effects of human, robot, and environmental characteristics were examined with an especial evaluation of the robot dimensions of performance and attribute-based factors. The robot performance and attributes were the largest contributors to the development of trust in HRI. Environmental factors played only a moderate role.
Conclusion: Factors related to the robot itself, specifically, its performance, had the greatest current association with trust, and environmental factors were moderately associated. There was little evidence for effects of human-related factors.
Application: The findings provide quantitative estimates of human, robot, and environmental factors influencing HRI trust. Specifically, the current summary provides effect size estimates that are useful in establishing design and training guidelines with reference to robot-related factors of HRI trust. Furthermore, results indicate that improper trust calibration may be mitigated by the manipulation of robot design. However, many future research needs are identified.
C1 [Hancock, Peter A.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
[Hancock, Peter A.; Billings, Deborah R.] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA.
[Schaefer, Kristin E.] Univ Cent Florida, Modeling & Simulat PhD Program, Orlando, FL 32816 USA.
[Chen, Jessie Y. C.] USA, Res Lab, Human Res & Engn Directorate, Orlando, FL USA.
[Parasuraman, Raja] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA.
RP Billings, DR (reprint author), Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
EM dbillings@knights.ucf.edu
FU U.S. Army Research Laboratory, under UCF [W911NF-10-2-0016]
FX The research reported in this document was performed in connection with
Contract No. W911NF-10-2-0016 with the U.S. Army Research Laboratory,
under UCF Task No. 3, P. A. Hancock, Principal Investigator. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as presenting the official policies or
position, either expressed or implied, of the U. S. Army Research
Laboratory or the U. S. government unless so designated by other
authorized documents. Citation of manufacturer's or trade names does not
constitute an official endorsement or approval of the use thereof. The
U. S. government is authorized to reproduce and distribute reprints for
government purposes notwithstanding any copyright notation herein. We
wish to thank the associate editor and two anonymous reviewers for their
most helpful comments in revising the present work.
NR 61
TC 81
Z9 81
U1 12
U2 38
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
J9 HUM FACTORS
JI Hum. Factors
PD OCT
PY 2011
VL 53
IS 5
BP 517
EP 527
DI 10.1177/0018720811417254
PG 11
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA 821JX
UT WOS:000294972400007
PM 22046724
ER
PT J
AU Grujicic, M
Arakere, G
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Arakere, G.
Yen, C. -F.
Cheeseman, B. A.
TI Computational Investigation of Hardness Evolution During Friction-Stir
Welding of AA5083 and AA2139 Aluminum Alloys
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE AA2139; AA5083; finite-element analysis; friction-stir welding; hardness
prediction
ID CU-MG-AG; MECHANICAL-PROPERTIES; MICROSTRUCTURAL EVOLUTION; 6061-T6
ALUMINUM; WELDED-JOINTS; ATOM-PROBE; PRECIPITATION; RECRYSTALLIZATION;
SUPERPLASTICITY; SIMULATION
AB A fully coupled thermo-mechanical finite-element analysis of the friction-stir welding (FSW) process developed in our previous work is combined with the basic physical metallurgy of two wrought aluminum alloys to predict/assess their FSW behaviors. The two alloys selected are AA5083 (a solid-solution strengthened and strain-hardened/stabilized Al-Mg-Mn alloy) and AA2139 (a precipitation hardened quaternary Al-Cu-Mg-Ag alloy). Both of these alloys are currently being used in military-vehicle hull structural and armor systems. In the case of non-age-hardenable AA5083, the dominant microstructure-evolution processes taking place during FSW are extensive plastic deformation and dynamic re-crystallization of highly deformed material subjected to elevated temperatures approaching the melting temperature. In the case of AA2139, in addition to plastic deformation and dynamic recrystallization, precipitates coarsening, over-aging, dissolution, and re-precipitation had to be also considered. Limited data available in the open literature pertaining to the kinetics of the aforementioned microstructure-evolution processes are used to predict variation in the material hardness throughout the various FSW zones of the two alloys. The computed results are found to be in reasonably good agreement with their experimental counterparts.
C1 [Grujicic, M.; Arakere, G.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM mica.grujicic@ces.clemson.edu
FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]
FX The material presented in this article is based on work supported by the
U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and
W911NF-06-2-0042.
NR 58
TC 33
Z9 33
U1 7
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD OCT
PY 2011
VL 20
IS 7
BP 1097
EP 1108
DI 10.1007/s11665-010-9741-y
PG 12
WC Materials Science, Multidisciplinary
SC Materials Science
GA 821GX
UT WOS:000294964100001
ER
PT J
AU Frost, NL
Grassbaugh, JA
Baird, G
Caskey, P
AF Frost, Nathan L.
Grassbaugh, Jason A.
Baird, Glen
Caskey, Paul
TI Triple Arthrodesis With Lateral Column Lengthening for the Treatment of
Planovalgus Deformity
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE triple arthrodesis; tarsal coalition; spastic flatfoot; lateral column
lengthening; pediatric
ID EXTRA-ARTICULAR ARTHRODESIS; LONG-TERM; VALGUS DEFORMITY; FOOT;
CHILDREN; FEET; HINDFOOT
AB Background: The rigid planovalgus foot has historically been difficult to correct and maintain in a corrected position with triple arthrodesis (TA). The lateral column lengthening (LCL) is a procedure that corrects the position of the planovalgus foot. Combining the TA with LCL at the calcaneocuboid joint may improve ultimate position after fusion for patients with rigid planovalgus foot deformities.
Methods: A retrospective review of all patients who underwent TA with LCL through the calcaneocuboid joint for rigid planovalgus foot deformity was performed. Preoperative and postoperative radiographs were compared for foot alignment by measuring the talo-first metatarsal angle in the anterior-posterior and lateral planes, calcaneal pitch, talo-horizontal angle, metatarsal stacking angle, and medial/lateral column ratio. Clinical outcomes were evaluated for correlation with preoperative and postoperative deformity and surgical indications. Results were evaluated using radiographic and clinic outcome measures developed for TA and LCL.
Results: Twenty-nine surgeries were identified with solid fusions occurring in 27 patients by 12 weeks postoperatively. Two patients with cerebral palsy had persistent hindfoot valgus. At an average follow-up of 32 months after surgical intervention, correction of the talo-first metatarsal angle in the AP and lateral planes, calcaneal pitch, and talo-horizontal angles were statistically significant. There were 25 good clinical results with minimal or no pain with activity (86.2%) and 4 poor or fair results with moderate or severe pain (13.8%). There were 26 radiographic successes (89.7%) and 3 radiographic failures (10.3%). Cerebral palsy was associated with a higher rate of radiographic failures (P = 0.01). There were 15 total complications in 11 feet (37.9%). These included 4 related to hardware, 3 involving neurological symptoms, 2 related to soft tissues, development of a symptomatic bony prominence in 2 patients, 1 forefoot deformity, 2 nonunions, and 1 case of Achilles tendonitis.
Conclusion: Good correction can be obtained and maintained with LCL and TA for rigid planovalgus foot deformity. The procedure is associated with good short-term clinical and radiographic outcomes and improves the position of the foot with diminished risk of recurrent or continued deformity as compared with historical controls.
C1 [Baird, Glen; Caskey, Paul] Spokane Shriners Hosp, Spokane, WA 99204 USA.
[Frost, Nathan L.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Grassbaugh, Jason A.] Womack Army Med Ctr, Ft Bragg, NC USA.
RP Caskey, P (reprint author), Spokane Shriners Hosp, 911 W 5th Ave, Spokane, WA 99204 USA.
EM Pcaskey@shrinenet.org
NR 23
TC 5
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD OCT-NOV
PY 2011
VL 31
IS 7
BP 773
EP 782
DI 10.1097/BPO.0b013e31822d3882
PG 10
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA 821TH
UT WOS:000294996800010
PM 21926876
ER
PT J
AU Eichinger, JK
Agochukwu, U
Franklin, J
Arrington, ED
Bluman, EM
AF Eichinger, Josef K.
Agochukwu, Uzondu
Franklin, Jillian
Arrington, Edward D.
Bluman, Eric M.
TI A New Reduction Technique for Completely Displaced Forearm and Wrist
Fractures in Children: A Biomechanical Assessment and 4-year Clinical
Evaluation
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE Lower Extremity-aided Fracture Reduction; bayoneted; distal radius;
reduction technique
ID DISTAL RADIAL FRACTURES; CLOSED REDUCTION; REDISPLACEMENT; MANIPULATION;
MANAGEMENT
AB Background: Most pediatric distal radius fractures are treated with closed methods, however, in recent years an increasing number of fractures are treated with operative management. Multiple reduction techniques are described in the orthopaedic literature but no recent advances have been made in the closed management of these injuries. We describe the efficacy of new, single-provider manual reduction technique that improves reduction efficacy and we separately show its biomechanical superiority to other common techniques.
Methods: Review the results of a new reduction technique, known as the Lower Extremity-aided Fracture Reduction (LEAFR) maneuver, used on a specific cohort of consecutively treated patients at a single institution over a 4-year period with bayoneted distal radius fractures. Intention-to-treat methodology and descriptive statistics are utilized to analyze accuracy of reduction, need for operative intervention, residual deformity, and complications. In addition, perform a biomechanical comparison between the LEAFR maneuver, the 2 person traction counter-traction method and finger traps.
Results: The technique allowed 24 consecutively treated, bayoneted distal radius fractures to be reduced from average translational and shortening deformities of 11.4 and 6.5mm to 2.1 and 0.4 mm, respectively (P < 0.0001). Two (8%) of the 24 patients had failure to eliminate bayonet displacement, whereas only 3 patients (12.5%) ultimately required operative intervention. No cases of growth arrest were noted. A biomechanical assessment of the maneuver showed the ability to generate an average of 597.8 Newtons (N) of axial traction which is statistically significant in comparison to other accepted methods of reduction.
Conclusions: The LEAFR is a clinically effective and biomechanically sound technique for reduction of bayoneted distal radius fractures in children. It is a simple, reproducible technique not reliant on equipment or additional skilled providers. In addition, it results in decreased rates of operative management and represents advancement in the treatment of pediatric distal radius fractures.
C1 [Eichinger, Josef K.] Womack Army Med Ctr, Dept Orthopaed, Ft Bragg, NC 28307 USA.
[Agochukwu, Uzondu; Arrington, Edward D.] Madigan Army Med Ctr, Orthopaed Serv, Fitzsimmons Dr Ft Lewis, WA USA.
[Bluman, Eric M.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Orthopaed, Boston, MA 02115 USA.
RP Eichinger, JK (reprint author), Womack Army Med Ctr, Dept Orthopaed, Ft Bragg, NC 28307 USA.
EM joe.eichinger@us.army.mil
NR 19
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD OCT-NOV
PY 2011
VL 31
IS 7
BP E73
EP E79
DI 10.1097/BPO.0b013e31822f1ad1
PG 7
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA 821TH
UT WOS:000294996800001
PM 21926867
ER
PT J
AU Sawka, MN
Leon, LR
Montain, SJ
Sonna, LA
AF Sawka, Michael N.
Leon, Lisa R.
Montain, Scott J.
Sonna, Larry A.
TI Integrated Physiological Mechanisms of Exercise Performance, Adaptation,
and Maladaptation to Heat Stress
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
AB This article emphasizes significant recent advances regarding heat stress and its impact on exercise performance, adaptations, fluid electrolyte imbalances, and pathophysiology. During exercise-heat stress, the physiological burden of supporting high skin blood flow and high sweating rates can impose considerable cardiovascular strain and initiate a cascade of pathophysiological events leading to heat stroke. We examine the association between heat stress, particularly high skin temperature, on diminishing cardiovascular/aerobic reserves as well as increasing relative intensity and perceptual cues that degrade aerobic exercise performance. We discuss novel systemic (heat acclimation) and cellular (acquired thermal tolerance) adaptations that improve performance in hot and temperate environments and protect organs from heat stroke as well as other dissimilar stresses. We delineate how heat stroke evolves from gut underperfusion/ischemia causing endotoxin release or the release of mitochondrial DNA fragments in response to cell necrosis, to mediate a systemic inflammatory syndrome inducing coagulopathies, immune dysfunction, cytokine modulation, and multiorgan damage and failure. We discuss how an inflammatory response that induces simultaneous fever and/or prior exposure to a pathogen (e. g., viral infection) that deactivates molecular protective mechanisms interacts synergistically with the hyperthermia of exercise to perhaps explain heat stroke cases reported in low-risk populations performing routine activities. Importantly, we question the "traditional" notion that high core temperature is the critical mediator of exercise performance degradation and heat stroke. Published 2011 This article is a U.S. Government work and is in the public domain in the USA. Compr Physiol 1: 1883-1928, 2011.
C1 [Sawka, Michael N.; Leon, Lisa R.; Montain, Scott J.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Sonna, Larry A.] Benefis Hlth Care Syst, Great Falls, MT USA.
RP Sawka, MN (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA.
EM Michael.Sawka@us.army.mil
NR 437
TC 86
Z9 88
U1 6
U2 71
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD OCT
PY 2011
VL 1
IS 4
BP 1883
EP 1928
DI 10.1002/cphy.c100082
PG 46
WC Physiology
SC Physiology
GA V27SM
UT WOS:000208632900010
PM 23733692
ER
PT J
AU Fraas, L
Avery, J
Minkin, L
Huang, HX
Uppal, P
AF Fraas, Lewis
Avery, James
Minkin, Leonid
Huang, Han Xiang
Uppal, Parvez
TI Portable Concentrated Sunlight Power Supply Using 40% Efficient Solar
Cells
SO IEEE JOURNAL OF PHOTOVOLTAICS
LA English
DT Article
DE Concentrated photovoltaics (CPV); high-efficiency solar cells; portable
electric power; III-V multijunction solar cells
AB A novel portable concentrated sunlight electric generator is described. It consists of two 2x3 point-focus Fresnel lens parquets which focus sunlight onto 12 high-efficiency triple junction solar cells mounted on two aluminum-backed circuit boards. These lens parquets, along with a linear tracker drive, can be stowed in a case roughly the size of a notebook computer. The two aluminum circuit boards form the top and bottom of this case. For deployment, the case is open, the lenses pop up, and the unit will generate 50W of electricity at 12V. The unit is deployed with a manual tilt to the South and with an electronic drive rotation from East to West around the North to South tilt axis. In the spring and fall, the unit will track on sun throughout the day, and in the summer, it will stay on sun for 4 h before requiring manual readjustment. Soldiers, campers, hikers, and outbackers use more and more electronics today, and consequently, they carry heavy batteries. The unit that is described here can be carried in a backpack. This concentrated sunlight electric generator can also be useful as a concentrated photovoltaic demonstration tool in science classes.
C1 [Fraas, Lewis; Avery, James; Minkin, Leonid; Huang, Han Xiang] JX Crystals Inc, Issaquah, WA 98027 USA.
[Uppal, Parvez] USA, Res Lab, Adelphi, MD 20783 USA.
RP Fraas, L (reprint author), JX Crystals Inc, Issaquah, WA 98027 USA.
EM lfraas@jxcrystals.com; jim.avery7@gmail.com; lminkin@jxcrystals.com;
huang@jxcrystals.com; parvez.uppal@us.army.mil
NR 5
TC 0
Z9 0
U1 1
U2 10
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2156-3381
J9 IEEE J PHOTOVOLT
JI IEEE J. Photovolt.
PD OCT
PY 2011
VL 1
IS 2
BP 236
EP 241
DI 10.1109/JPHOTOV.2011.2172576
PG 6
WC Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied
SC Energy & Fuels; Materials Science; Physics
GA V28RJ
UT WOS:000208697600021
ER
PT J
AU Shaw, M
Quezada, SA
Zarate, MA
AF Shaw, Moira
Quezada, Stephanie A.
Zarate, Michael A.
TI Violence With a Conscience: Religiosity and Moral Certainty as
Predictors of Support for Violent Warfare
SO PSYCHOLOGY OF VIOLENCE
LA English
DT Article
DE moral certainty; religion; violent warfare; moral licensing
AB Objective: Emerging research on the moral licensing effect implies that increasing a person's moral certainty may decrease concerns about the moral consequences of violent warfare. Therefore, if religion increases moral certainty, then it may also contribute to support for violent warfare. The present experiment tested the extent to which religion's contribution to moral certainty explains participants' support for the United States' War in the Middle East. Method: Ninety:three predominantly Catholic and Protestant participants from a university setting completed the present study. The study was completed across two separate days. On the first day of the experiment, individual differences in a variety of types of religiosity (e.g., prayer), and moral certainty were measured. On the second day of the experiment, the perception that the United States' war in the Middle East is a religious or geopolitical conflict was experimentally manipulated, and support for violent warfare was measured. Results: Regression analyses and an analysis of variance yielded support for the moral certainty hypothesis. As predicted, greater religiosity relates to greater moral certainty, and greater moral certainty strengthens the (positive) relation between religiosity and support for violent warfare. Furthermore, moral certainty is a stronger predictor of support for violent warfare in religious conflict than it is in geopolitical conflict. Conclusion: The results support the moral certainty hypothesis and suggest that stronger moral certainty (1) predicts greater support for violent warfare, (2) is an underlying moderator of the relation between religiosity and support for violent warfare, and (3) is particularly influential in religious conflict.
C1 [Shaw, Moira; Quezada, Stephanie A.; Zarate, Michael A.] Univ Texas El Paso, Dept Psychol, El Paso, TX 79968 USA.
RP Shaw, M (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM moira.p.shaw@us.army.mil
NR 29
TC 4
Z9 4
U1 1
U2 12
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 2152-0828
J9 PSYCHOL VIOLENCE
JI Psychol. Violence
PD OCT
PY 2011
VL 1
IS 4
BP 275
EP 286
DI 10.1037/a0025346
PG 12
WC Psychology, Clinical; Criminology & Penology; Family Studies
SC Psychology; Criminology & Penology; Family Studies
GA V27TP
UT WOS:000208635800002
ER
PT J
AU Akers, KS
Cota, JM
Frei, CR
Chung, KK
Mende, K
Murray, CK
AF Akers, Kevin S.
Cota, Jason M.
Frei, Christopher R.
Chung, Kevin K.
Mende, Katrin
Murray, Clinton K.
TI Once-Daily Amikacin Dosing in Burn Patients Treated with Continuous
Venovenous Hemofiltration
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID RENAL REPLACEMENT THERAPY; ACUTE KIDNEY INJURY; CALCOACETICUS COMPLEX;
PHARMACOKINETICS; INFECTIONS; RESISTANCE; REGIMENS; SEPSIS
AB Amikacin clearance can be increased in burn injury, which is often complicated by renal insufficiency. Little is known about the impact of renal replacement therapies, such as continuous venovenous hemofiltration (CVVH), on amikacin pharmacokinetics. We retrospectively examined the clinical pharmacokinetics, bacteriology, and clinical outcomes of 60 burn patients given 15 mg/kg of body weight of amikacin in single daily doses. Twelve were treated with concurrent CVVH therapy, and 48 were not. The pharmacodynamic target of >= 10 for the maximum concentration of drug in serum divided by the MIC (C-max/MIC) was achieved in only 8.5% of patients, with a small reduction of C-max in patients receiving CVVH and no difference in amikacin clearance. Mortality and burn size were greater in patients who received CVVH. Overall, 172 Gram-negative isolates were recovered from the blood cultures of 39 patients, with amikacin MIC data available for 82 isolates from 24 patients. A 10,000-patient Monte Carlo simulation was conducted incorporating pharmacokinetic and MIC data from these patients. The cumulative fraction of response (CFR) was similar in CVVH and non-CVVH patients. The CFR rates were not significantly improved by a theoretical 20 mg/kg amikacin dose. Overall, CVVH did not appear to have a major impact on amikacin serum concentrations. The low pharmacodynamic target attainment appears to be primarily due to higher amikacin MICs rather than more rapid clearance of amikacin related to CVVH therapy.
C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Cota, Jason M.] Univ Incarnate Word Feik Sch Pharm, Dept Pharm Practice, San Antonio, TX 78209 USA.
[Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
[Chung, Kevin K.] USA, Burn Intens Care Unit, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78229 USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM clinton.murray@us.army.mil
RI Valle, Ruben/A-7512-2013
FU U.S. National Institutes of Health (NIH) [RR025766]
FX C.R.F. is supported by the U.S. National Institutes of Health (NIH) in
the form of an NIH/KL2 career development award (RR025766).
NR 21
TC 14
Z9 15
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2011
VL 55
IS 10
BP 4639
EP 4642
DI 10.1128/AAC.00374-11
PG 4
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 821CO
UT WOS:000294952600021
PM 21825289
ER
PT J
AU Markelz, AE
Mende, K
Murray, CK
Yu, X
Zera, WC
Hospenthal, DR
Beckius, ML
Calvano, T
Akers, KS
AF Markelz, Ana Elizabeth
Mende, Katrin
Murray, Clinton K.
Yu, Xin
Zera, Wendy C.
Hospenthal, Duane R.
Beckius, Miriam L.
Calvano, Tatjana
Akers, Kevin S.
TI Carbapenem Susceptibility Testing Errors Using Three Automated Systems,
Disk Diffusion, Etest, and Broth Microdilution and Carbapenem Resistance
Genes in Isolates of Acinetobacter baumannii-calcoaceticus Complex
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID GRAM-NEGATIVE BACILLI; ANTIMICROBIAL SUSCEPTIBILITY; MULTIPLEX PCR;
UNITED-STATES; BD PHOENIX; VITEK 2; IDENTIFICATION; DORIPENEM; EMERGENCE
AB The Acinetobacter baumannii-calcoaceticus complex (ABC) is associated with increasing carbapenem resistance, necessitating accurate resistance testing to maximize therapeutic options. We determined the accuracy of carbapenem antimicrobial susceptibility tests for ABC isolates and surveyed them for genetic determinants of carbapenem resistance. A total of 107 single-patient ABC isolates from blood and wound infections from 2006 to 2008 were evaluated. MICs of imipenem, meropenem, and doripenem determined by broth microdilution (BMD) were compared to results obtained by disk diffusion, Etest, and automated methods (the MicroScan, Phoenix, and Vitek 2 systems). Discordant results were categorized as very major errors (VME), major errors (ME), and minor errors (mE). DNA sequences encoding OXA beta-lactamase enzymes (bla(OXA-23-like), bla(OXA-24-like), bla(OXA-58-like), and bla(OXA-51-like)) and metallo-beta-lactamases (MBLs) (IMP, VIM, and SIM1) were identified by PCR, as was the KPC2 carbapenemase gene. Imipenem was more active than meropenem and doripenem. The percentage of susceptibility was 37.4% for imipenem, 35.5% for meropenem, and 3.7% for doripenem. Manual methods were more accurate than automated methods. bla(OXA-23-like) and bla(OXA-24-like) were the primary resistance genes found. bla(OXA-58-like), MBLs, and KPC2 were not present. Both automated testing and manual testing for susceptibility to doripenem were very inaccurate, with VME rates ranging between 2.8 and 30.8%. International variability in carbapenem breakpoints and the absence of CLSI breakpoints for doripenem present a challenge in susceptibility testing.
C1 [Murray, Clinton K.] Brooke Army Med Ctr, LTC, MC, USA,Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Murray, Clinton K.; Hospenthal, Duane R.; Akers, Kevin S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Mende, Katrin; Zera, Wendy C.] Infect Dis Clin Res Program, Bethesda, MD USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, LTC, MC, USA,Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Clinton.Murray@amedd.army.mil
NR 24
TC 12
Z9 12
U1 1
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2011
VL 55
IS 10
BP 4707
EP 4711
DI 10.1128/AAC.00112-11
PG 5
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 821CO
UT WOS:000294952600030
PM 21807971
ER
PT J
AU Sutter, DE
Summers, AM
Keys, CE
Taylor, KL
Frasch, CE
Braun, LE
Fattom, AI
Bash, MC
AF Sutter, Deena E.
Summers, Amy M.
Keys, Christine E.
Taylor, Kimberly L.
Frasch, Carl E.
Braun, LoRanee E.
Fattom, Ali I.
Bash, Margaret C.
TI Capsular serotype of Staphylococcus aureus in the era of
community-acquired MRSA
SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
LA English
DT Article
DE Staphylococcus aureus; MRSA; pediatric; community acquired; capsule
ID PANTON-VALENTINE LEUKOCIDIN; UNITED-STATES; TEICHOIC-ACIDS;
GENETIC-LOCI; INFECTIONS; POLYSACCHARIDE; PNEUMONIA; VIRULENCE; MODEL;
SKIN
AB Capsular polysaccharide (CP) plays an important role in the pathogenicity and immunogenicity of Staphylococcus aureus, yet the common serotypes of S. aureus isolated from US pediatric patients have not been reported. We investigated capsular serotype as well as methicillin susceptibility, presence of Panton-Valentine leukocidin (PVL), and clonal relatedness of pediatric S. aureus isolates. Clinical isolates were tested for methicillin susceptibility, presence of mecA, lukS-PV and lukF-PV, cap5 and cap8 genes by PCR, and for capsular or surface polysaccharide expression (CP5, CP8, or 336 polysaccharide) by agglutination. Genetic relatedness was determined by pulsed-field gel electrophoresis. All S. aureus isolates encoded cap5 or cap8. Sixty-nine percent of 2004-2005 isolates were methicillin-susceptible (MSSA) and most expressed a detectable capsule. The majority of MRSA isolates (82%) were unencapsulated, exposing an expressed cell wall techoic acid antigen 336. Pulsed-field type USA300 were MRSA, PVL-positive, unencapsulated strains that were associated with deep skin infections and recurrent disease. Over half (58%) of all isolates from invasive pediatric dermatologic infections were USA300. All pediatric isolates contained either capsule type 5 or capsule type 8 genes, and roughly half of the S. aureus clinical disease isolates from our population were diverse MSSA-encapsulated strains. The majority of the remaining pediatric clinical disease isolates were unencapsulated serotype 336 strains of the PVL(1) USA300 community-associated-MRSA clone.
C1 [Sutter, Deena E.; Frasch, Carl E.; Bash, Margaret C.] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA.
[Summers, Amy M.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA.
[Keys, Christine E.; Fattom, Ali I.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA.
[Taylor, Kimberly L.] Nabi Biopharmaceut, Rockville, MD USA.
[Sutter, Deena E.; Braun, LoRanee E.; Bash, Margaret C.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
RP Sutter, DE (reprint author), Brooke Army Med Ctr, Dept Pediat, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM deena.sutter@amedd.army.mil
NR 34
TC 15
Z9 15
U1 1
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0928-8244
J9 FEMS IMMUNOL MED MIC
JI FEMS Immunol. Med. Microbiol.
PD OCT
PY 2011
VL 63
IS 1
BP 16
EP 24
DI 10.1111/j.1574-695X.2011.00822.x
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 820TQ
UT WOS:000294928900003
PM 21631600
ER
PT J
AU Schmiel, DH
Moran, EE
Keiser, PB
Brandt, BL
Zollinger, WD
AF Schmiel, Deborah H.
Moran, Elizabeth E.
Keiser, Paul B.
Brandt, Brenda L.
Zollinger, Wendell D.
TI Importance of Antibodies to Lipopolysaccharide in Natural and
Vaccine-Induced Serum Bactericidal Activity against Neisseria
meningitidis Group B
SO INFECTION AND IMMUNITY
LA English
DT Article
ID INVASIVE MENINGOCOCCAL DISEASE; MEMBRANE VESICLE VACCINE; HUMAN
DENDRITIC-CELLS; SEROGROUP-B; GROUP-A; LIPOOLIGOSACCHARIDES LOS; CORE
OLIGOSACCHARIDES; POLYACRYLAMIDE GELS; STRAIN NMB; IMMUNOGENICITY
AB Analysis of the specificity of bactericidal antibodies in normal, convalescent, and postvaccination human sera is important in understanding human immunity to meningococcal infections and can aid in the design of an effective group B vaccine. A collection of human sera, including group C and group B convalescent-phase sera, normal sera with naturally occurring cross-reactive bactericidal activity, and some postvaccination sera, was analyzed to determine the specificity of cross-reactive bactericidal antibodies. Analysis of human sera using a bactericidal antibody depletion assay demonstrated that a significant portion of the bactericidal activity could be removed by purified lipopolysaccharide (LPS). LPS homologous to that expressed on the bactericidal test strain was most effective, but partial depletion by heterologous LPS suggested the presence of antibodies with various degrees of cross-reactivity. Binding of anti-L3,7 LPS bactericidal antibodies was affected by modification of the core structure, suggesting that these functional antibodies recognized epitopes consisting of both core structures and lacto-N-neotetraose (LNnT). When the target strain was grown with 5'-cytidinemonophospho-N-acetylneuraminic acid (CMP-NANA) to increase LPS sialylation, convalescent-phase serum bactericidal titers were decreased by only 2- to 4-fold, and most remaining bactericidal activity was still depleted by LPS. Highly sialylated LPS was ineffective in depleting bactericidal antibodies. We conclude that natural infections caused by strains expressing L3,7 LPS induce persistent, protective bactericidal antibodies and appear to be directed against nonsialylated bacterial epitopes. Additionally, subsets of these bactericidal antibodies are cross-reactive, binding to several different LPS immunotypes, which is a useful characteristic for an effective group B meningococcal vaccine antigen.
C1 [Schmiel, Deborah H.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Schmiel, DH (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM deb.schmiel1@us.army.mil
FU U.S. Army Medical Research and Materiel Command through the Military
Infectious Disease Research office
FX This work was supported by the U.S. Army Medical Research and Materiel
Command through the Military Infectious Disease Research Program office.
NR 69
TC 6
Z9 6
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD OCT
PY 2011
VL 79
IS 10
BP 4146
EP 4156
DI 10.1128/IAI.05125-11
PG 11
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 821BY
UT WOS:000294951000030
PM 21768280
ER
PT J
AU Miyata, T
Harakuni, T
Tsuboi, T
Sattabongkot, J
Ikehara, A
Tachibana, M
Torii, M
Matsuzaki, G
Arakawa, T
AF Miyata, Takeshi
Harakuni, Tetsuya
Tsuboi, Takafumi
Sattabongkot, Jetsumon
Ikehara, Ayumu
Tachibana, Mayumi
Torii, Motomi
Matsuzaki, Goro
Arakawa, Takeshi
TI Tricomponent Immunopotentiating System as a Novel Molecular Design
Strategy for Malaria Vaccine Development
SO INFECTION AND IMMUNITY
LA English
DT Article
ID B-CELL ACTIVATION; ANTIGEN-PRESENTING CELLS; CHOLERA-TOXIN; DENDRITIC
CELLS; CROSS-LINKING; TRANSMISSION; PROTEIN; IMMUNIZATION; IMMUNITY;
PVS25
AB The creation of subunit vaccines to prevent malaria infection has been hampered by the intrinsically weak immunogenicity of the recombinant antigens. We have developed a novel strategy to increase immune responses by creating genetic fusion proteins to target specific antigen-presenting cells (APCs). The fusion complex was composed of three physically linked molecular entities: (i) a vaccine antigen, (ii) a multimeric alpha-helical coiled-coil core, and (iii) an APC-targeting ligand linked to the core via a flexible linker. The vaccine efficacy of the tricomponent complex was evaluated using an ookinete surface protein of Plasmodium vivax, Pvs25, and merozoite surface protein-1 of Plasmodium yoelii. Immunization of mice with the tricomponent complex induced a robust antibody response and conferred substantial levels of P. vivax transmission blockade as evaluated by a membrane feed assay, as well as protection from lethal P. yoelii infection. The observed effect was strongly dependent on the presence of all three components physically integrated as a fusion complex. This system, designated the tricomponent immunopotentiating system (TIPS), onto which any recombinant protein antigens or nonproteinaceous substances could be loaded, may be a promising strategy for devising subunit vaccines or adjuvants against various infectious diseases, including malaria.
C1 [Miyata, Takeshi; Harakuni, Tetsuya; Ikehara, Ayumu; Matsuzaki, Goro; Arakawa, Takeshi] Univ Ryukyus, COMB, Trop Biosphere Res Ctr, Mol Microbiol Grp,Dept Trop Infect Dis, Okinawa 9030213, Japan.
[Matsuzaki, Goro; Arakawa, Takeshi] Univ Ryukyus, Grad Sch Med, Dept Microbiol, Div Host Def & Vaccinol, Okinawa 9030213, Japan.
[Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan.
[Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan.
[Tsuboi, Takafumi; Torii, Motomi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan.
[Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Dept Mol Parasitol, Grad Sch Med, Toon, Ehime 7910295, Japan.
[Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
RP Arakawa, T (reprint author), Univ Ryukyus, COMB, Trop Biosphere Res Ctr, Mol Microbiol Grp,Dept Trop Infect Dis, 1 Senbaru, Okinawa 9030213, Japan.
EM tarakawa@comb.u-ryukyu.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
[20590425, 21022034]; Basic Research Activities for Innovative
Biosciences from the Bio-oriented Technology Research Advancement
Institution; Institute of Tropical Medicine, Nagasaki University,
Nagasaki, Japan; Okinawa Industry Promotion Public Corp. (Naha, Okinawa,
Japan)
FX This work was supported by the following grants: Grants-in-Aid for
Scientific Research (20590425) and Scientific Research on Priority Areas
(21022034) from the Ministry of Education, Culture, Sports, Science and
Technology, Japan; the Program for Promotion of Basic Research
Activities for Innovative Biosciences from the Bio-oriented Technology
Research Advancement Institution; the Cooperative Research Grant from
the Institute of Tropical Medicine, Nagasaki University, Nagasaki,
Japan; and a research grant from the Okinawa Industry Promotion Public
Corp. (Naha, Okinawa, Japan).
NR 34
TC 12
Z9 12
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD OCT
PY 2011
VL 79
IS 10
BP 4260
EP 4275
DI 10.1128/IAI.05214-11
PG 16
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 821BY
UT WOS:000294951000042
PM 21807905
ER
PT J
AU Edamana, B
Hahn, B
Pulskamp, JS
Polcawich, RG
Oldham, K
AF Edamana, Biju
Hahn, Bongsu
Pulskamp, Jeffrey S.
Polcawich, Ronald G.
Oldham, Kenn
TI Modeling and Optimal Low-Power On-Off Control of Thin-Film Piezoelectric
Rotational Actuators
SO IEEE-ASME TRANSACTIONS ON MECHATRONICS
LA English
DT Article
DE Integer programming; microactuators; micro-electromechanical devices;
on-off control; piezoelectric devices; switched systems
ID FUEL USAGE; MEMS
AB A novel open-loop minimal energy on-off servo system and control strategy are described for ensuring specified displacements from new microscale piezoelectric rotational joints under extremely strict power budgets. The rotational joints are driven by thin-film lead-zirconate-titanate actuators and are targeted for use in autonomous terrestrial microrobots. A lumped-parameter, second-order model of anticipated joint behavior is utilized to estimate the natural frequency and damping ratio of the robot joints, which, in turn, are used to identify necessary sampling rates and switching drive circuit parameters for implementation of on-off control. An identified model of leg joint behavior is then used to both verify lumped-parameter modeling and to optimize on-off input sequences to the rotary joint. The optimization procedure incorporates energy costs from both switching and holding an input voltage on microactuators that behave as a capacitive load, while ensuring that specified final states of a dynamic system are achieved at a specified point in time. Optimization is done via a new application of binary programming. In addition, modest robustness of the system response to parameter variation can be produced during control sequence generation. Optimized input sequences are applied to both macroscale piezoelectric actuators and to prototype thin-film piezoelectric leg joints, and show that specified actuator motions can be achieved with energy consumption of less than 5 mu J per movement.
C1 [Edamana, Biju; Hahn, Bongsu; Oldham, Kenn] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Pulskamp, Jeffrey S.; Polcawich, Ronald G.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Edamana, B (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
EM bij@umich.edu; suhahn@umich.edu; jeffrey.pulskamp@arl.army.mil;
ronald.polcawich@arl.army.mil; oldham@umich.edu
FU U.S. Defense Advanced Research Projects Agency [HR0011-08-1-0040]; U.S.
Army Research Office [W911QX-07-C-0072]
FX This work was supported in part by the U.S. Defense Advanced Research
Projects Agency under Grant HR0011-08-1-0040 and in part by the U.S.
Army Research Office under Grant W911QX-07-C-0072.
NR 23
TC 11
Z9 11
U1 7
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1083-4435
J9 IEEE-ASME T MECH
JI IEEE-ASME Trans. Mechatron.
PD OCT
PY 2011
VL 16
IS 5
BP 884
EP 896
DI 10.1109/TMECH.2010.2053041
PG 13
WC Automation & Control Systems; Engineering, Manufacturing; Engineering,
Electrical & Electronic; Engineering, Mechanical
SC Automation & Control Systems; Engineering
GA 815SU
UT WOS:000294550100014
ER
PT J
AU Bowden, LP
Royer, MC
Hallman, JR
Lewin-Smith, M
Lupton, GP
AF Bowden, Lynden P.
Royer, Michael C.
Hallman, James R.
Lewin-Smith, Michael
Lupton, George P.
TI Rapid onset of argyria induced by a silver-containing dietary supplement
SO JOURNAL OF CUTANEOUS PATHOLOGY
LA English
DT Article
DE argyria; discoloration; ingestion; silver; supplement
ID COLLOIDAL SILVER; GENERALIZED ARGYRIA; INGESTION; SECONDARY; PROTEIN
AB We describe a 53-year-old man in good general health who presented with an 8-month history of progressive gray hyperpigmentation of the face. He denied using any prescription medications; however, he admitted to taking a herbal supplement. Clinically, the differential diagnosis included hemochromatosis, Wilson's disease and hyperpigmentation secondary to supplement use. Punch biopsies from the left forehead and preauricular region showed heavily sun-damaged skin with a minimal inflammatory infiltrate. Closer inspection, however, revealed minute scattered black/brown particles distributed in the basement membrane zone of eccrine and sebaceous glands. Similar particles were also present in hair follicles, blood vessels and arrector pili muscles. The particles did not stain with Gomori methenamine silver, Fontana-Masson or iron stains. Electron microscopy with energy-dispersive x-ray analysis showed numerous particles, less than 1 mu m in greatest dimension, which showed peaks for silver and sulfur. This analytical result confirmed the impression of argyria. Further history revealed that the patient had indeed been taking a silver supplement for several months under the premise that it would boost his immune system. This case is unique in that the patient's hyperpigmentation developed in a short period of time as compared with other reports in the medical literature.
C1 [Bowden, Lynden P.] Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, Washington, DC 20307 USA.
[Royer, Michael C.] Natl Naval Med Ctr, Dept Pathol & Lab Serv, Bethesda, MD USA.
[Hallman, James R.; Lupton, George P.] Armed Forces Inst Pathol, Dept Dermatopathol, Washington, DC 20306 USA.
[Lewin-Smith, Michael] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA.
RP Bowden, LP (reprint author), Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM pete.bowden@me.com
NR 21
TC 18
Z9 18
U1 3
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0303-6987
J9 J CUTAN PATHOL
JI J. Cutan. Pathol.
PD OCT
PY 2011
VL 38
IS 10
BP 832
EP 835
DI 10.1111/j.1600-0560.2011.01755.x
PG 4
WC Dermatology; Pathology
SC Dermatology; Pathology
GA 815YX
UT WOS:000294567000014
PM 21883362
ER
PT J
AU Jackson, WM
Aragon, AB
Onodera, J
Koehler, SM
Ji, YM
Bulken-Hoover, JD
Vogler, JA
Tuan, RS
Nesti, LJ
AF Jackson, Wesley M.
Aragon, Amber B.
Onodera, Jun
Koehler, Steven M.
Ji, Youngmi
Bulken-Hoover, Jamie D.
Vogler, Jared A.
Tuan, Rocky S.
Nesti, Leon J.
TI Cytokine Expression in Muscle following Traumatic Injury
SO JOURNAL OF ORTHOPAEDIC RESEARCH
LA English
DT Article
DE muscle injury; heterotopic ossification; cytokines; bone morphogenetic
protein; gene expression profiling
ID FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; HETEROTOPIC OSSIFICATION;
PROGENITOR CELLS; TRANSFORMING GROWTH-FACTOR-BETA-1; GENETIC DISORDER;
SKELETOGENESIS; REGENERATION; TGF-BETA(1); GROWTH
AB Heterotopic ossification (HO) occurs at a high frequency in severe orthopaedic extremity injuries; however, the etiology of traumatic HO is virtually unknown. Osteogenic progenitor cells have previously been identified within traumatized muscle. Although the signaling mechanisms that lead to this dysregulated differentiation pathway have not been identified, it is assumed that inflammation and fibrosis, which contribute to an osteoinductive environment, are necessary for the development of HO. The hypothesis of this study was that cytokines related to chronic inflammation, fibrogenesis, and osteogenesis become up-regulated following severe muscle trauma where HO forms. Classification of these cytokines by their differential expression relative to control muscle will provide guidance for further study of the mechanisms leading to HO. Real-time RT-PCR analysis revealed no significant up-regulation of cytokines typically associated with HO (e.g., BMP-4, as observed in the genetic form of HO, fibrodysplasia ossificans progressiva). Instead, the cytokine gene expression profile associated with the traumatized muscle included up-regulation of cytokines associated with osteogenesis and fibrosis (i.e., BMP-1 and TGF-beta(1)). Using immunohistochemistry, these cytokines were localized to fibroproliferative lesions, which have previously been implicated in HO. This study identifies other cell and tissue-level interactions in traumatized muscle that should be investigated further to better define the etiology of HO. (C) 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:1613-1620, 2011
C1 [Jackson, Wesley M.; Aragon, Amber B.; Onodera, Jun; Koehler, Steven M.; Ji, Youngmi; Bulken-Hoover, Jamie D.; Vogler, Jared A.; Tuan, Rocky S.; Nesti, Leon J.] NIH, Cartilage Biol & Orthopaed Branch, Inst Arthrit & Musculoskeletal & Skin Dis, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Jackson, Wesley M.; Vogler, Jared A.; Nesti, Leon J.] NIAMSD, Clin & Expt Orthopaed Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Aragon, Amber B.; Bulken-Hoover, Jamie D.; Vogler, Jared A.; Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
[Tuan, Rocky S.] Univ Pittsburgh, Sch Med, Dept Orthopaed Surg, Ctr Cellular & Mol Engn, Pittsburgh, PA 15219 USA.
RP Nesti, LJ (reprint author), NIH, Cartilage Biol & Orthopaed Branch, Inst Arthrit & Musculoskeletal & Skin Dis, Dept Hlth & Human Serv, 50 South Dr,Room 1140,MSC 8022, Bethesda, MD 20892 USA.
EM rst13@pitt.edu; leonnesti@gmail.com
RI Onodera, Jun/D-7142-2012
FU WRAMC [PO5-A011]; NIH [Z01 AR41131]; Commonwealth of Pennsylvania,
Department of Health; U.S. Army Medical Research & Material Command;
Telemedicine & Advanced Technology Research Center [W81XWH-10-1-0618]
FX This work was supported by the Military Amputee Research Program at
WRAMC (PO5-A011), the NIH Intramural Research Program (Z01 AR41131), the
Commonwealth of Pennsylvania, Department of Health, the U.S. Army
Medical Research & Material Command, and the Telemedicine & Advanced
Technology Research Center (W81XWH-10-1-0618 to Pittsburgh Tissue
Engineering Initiative).
NR 23
TC 25
Z9 26
U1 1
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0736-0266
J9 J ORTHOP RES
JI J. Orthop. Res.
PD OCT
PY 2011
VL 29
IS 10
BP 1613
EP 1620
DI 10.1002/jor.21354
PG 8
WC Orthopedics
SC Orthopedics
GA 816IV
UT WOS:000294592800023
PM 21452302
ER
PT J
AU St Clair, JG
Behrens, DA
Lee, IC
AF St Clair, Jeffrey G.
Behrens, Douglas A.
Lee, Ivan C.
TI Catalytic combustion of 1-butanol coupled with heat harvesting for
compact power
SO COMBUSTION AND FLAME
LA English
DT Article
DE 1-Butanol; Catalytic combustion; Heat harvester
ID MONODISPERSE ELECTROSPRAYS; BUTANOL; CONDUCTIVITY; OXIDATION; PRESSURE;
SYSTEMS
AB A combustor paired with a heat-harvesting device, such as a thermoelectric or thermal photovoltaic device, can utilize high energy-dense liquid fuels while avoiding direct chemical-to-electrical conversion issues such as electrode and electrolyte poisoning. Therefore, the system is an attractive alternative to batteries and fuel cells for portable power applications. In the current study, a 1-butanol fed catalytic combustor using a Rh/Al(2)O(3) catalyst was tested with a heat extractor, in this case being a stainless steel rod with a copper heat sink that was designed to thermally mimic a small thermoelectric module. The effects of residence time, fuel flow rate, and rod size on reactor/extractor temperatures and the energy balance were observed. Fuel-lean equivalence ratios were also studied and shown to have little effect on performance. Residence time does not have a direct effect; however, it does provide a catalytic stability limit for the fuel flow rate. The difference in the hot and cold side temperatures of the rod is dependent on the fuel flow rate and length of the rod. The greatest difference observed in these temperatures was 513 degrees C using the long-sized (15 cm) rod. The percentage of fuel energy conducted through the rod is only dependent on the rod size, with a maximum around 40% using the short rod. These results provide important design guidelines for the catalytic combustion of energy-dense liquid fuels as an excellent alternative heat source for either direct use or electrical power conversion. Published by Elsevier Inc. on behalf of The Combustion Institute.
C1 [St Clair, Jeffrey G.; Behrens, Douglas A.; Lee, Ivan C.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Lee, IC (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ivan@us.army.mil
RI Lee, Ivan/H-6444-2011
NR 24
TC 2
Z9 2
U1 2
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0010-2180
J9 COMBUST FLAME
JI Combust. Flame
PD OCT
PY 2011
VL 158
IS 10
BP 1890
EP 1897
DI 10.1016/j.combustflame.2011.02.019
PG 8
WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary;
Engineering, Chemical; Engineering, Mechanical
SC Thermodynamics; Energy & Fuels; Engineering
GA 815KT
UT WOS:000294525200004
ER
PT J
AU Thomas, SJ
Endy, TP
AF Thomas, Stephen J.
Endy, Timothy P.
TI Critical issues in dengue vaccine development
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE dengue virus; development; vaccine
ID ANTIBODY-DEPENDENT ENHANCEMENT; COMPLETE GENOME SEQUENCES;
HEMORRHAGIC-FEVER; VIRUS-INFECTION; DISEASE SEVERITY; NEUTRALIZING
ANTIBODY; NATURAL-POPULATIONS; DENDRITIC CELLS; RHESUS-MONKEYS;
WEST-NILE
AB Purpose of review
Dengue is currently an expanding global health problem. Development of an effective tetravalent dengue vaccine is considered a high public health priority. The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection has made dengue vaccine development difficult. This review focuses on the current critical issues in dengue vaccine development.
Recent findings
DENVs are arboviral flaviviruses transmitted by Aedes mosquitoes causing a spectrum of clinical disease. DENV infections are a significant global health problem; the WHO estimates that more than 120 countries have endemic DENV transmission resulting in 70-500 million infections, 2.1 million clinically severe cases, and 21 000 deaths annually. There are currently no licensed antivirals or vaccines to treat or prevent dengue. The DENV-host interaction of infection is unique with severe disease a consequence of sequential dengue infection, viral immune evasion, host antibody enhancement, host immune activation, and genetic predisposition. This unique pathogen-host interaction complicates dengue vaccine development and creates provocative questions in vaccine development such as identifying markers of protective immunogenicity, the potential role of antibody in vaccine failures, and the possible impact of large-scale vaccination on the evolution of wild-type DENV.
Summary
Dengue is a unique and complex disease; developing a dengue vaccine has proven equally complex. In this review, the authors discuss issues that will prove to be critical to the success or failure of the dengue vaccine development effort.
C1 [Endy, Timothy P.] SUNY Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY 13210 USA.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
RP Endy, TP (reprint author), SUNY Upstate Med Univ, Dept Med, Div Infect Dis, 725 Irving Ave,Suite 304, Syracuse, NY 13210 USA.
EM endyt@upstate.edu
NR 62
TC 64
Z9 67
U1 2
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7375
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD OCT
PY 2011
VL 24
IS 5
BP 442
EP 450
DI 10.1097/QCO.0b013e32834a1b0b
PG 9
WC Infectious Diseases
SC Infectious Diseases
GA 814UD
UT WOS:000294481800007
PM 21799408
ER
PT J
AU Schwartz, RB
Reynolds, BZ
Shiver, SA
Lerner, EB
Greenfield, EM
Solis, RA
Kimpel, NA
Coule, PL
McManus, JG
AF Schwartz, Richard Bruce
Reynolds, Bradford Zahner
Shiver, Stephen A.
Lerner, E. Brooke
Greenfield, Eric Mark
Solis, Ricaurte A.
Kimpel, Nicholas A.
Coule, Phillip L.
McManus, John G.
TI COMPARISON OF TWO PACKABLE HEMOSTATIC GAUZE DRESSINGS IN A PORCINE
HEMORRHAGE MODEL
SO PREHOSPITAL EMERGENCY CARE
LA English
DT Article
DE hemostatic agent; hemorrhage; gunshot wound; ChitoGauze; Combat Gauze;
combat medicine
ID EXTREMITY ARTERIAL HEMORRHAGE; OPERATION-ENDURING-FREEDOM; CHITOSAN
ACETATE BANDAGE; COMBAT OPERATIONS; IRAQI-FREEDOM; LETHAL MODEL; CASE
SERIES; INJURY; AGENT; SWINE
AB Background. Uncontrolled hemorrhage remains the primary cause of preventable battlefield mortality and a significant cause of domestic civilian mortality. Rapid hemorrhage control is crucial for survival. ChitoGauze and Combat Gauze are commercially available products marketed for rapid hemorrhage control. These products were selected because they are packable gauze that work via differing mechanisms of action (tissue adhesion versus procoagulant). Objective. To compare the effectiveness of ChitoGauze and Combat Gauze in controlling arterial hemorrhage in a swine model. Methods. Fourteen swine were studied. Following inguinal dissection and after achieving minimum hemodynamic parameters (mean arterial pressure [MAP] >= 70 mmHg), a femoral arterial injury was created using a 6-mm vascular punch. Free bleeding was allowed for 45 seconds, and then the wound was packed alternatively with ChitoGauze or Combat Gauze. Direct pressure was applied to the wound for 2 minutes, followed by a three-hour monitoring period. Resuscitation fluids were administered to maintain an MAP of >= 65 mmHg. Time to hemostasis, hemodynamic parameters, total blood loss, and amount of resuscitation fluid were recorded every 15 minutes. Data were analyzed using the Wilcoxon rank sum test. Histologic sections of the vessels were examined using regular and polarized light. Results. No statistically significant differences were found between the groups regarding any measured end point. Data trends, however, favor ChitoGauze over Combat Gauze for time to hemostasis, fluid requirements, and blood loss. There was no evidence of retained foreign material on histologic analysis. Conclusion. ChitoGauze and Combat Gauze appear to be equally efficacious in their hemostatic proper-ties, as demonstrated in a porcine hemorrhage model.
C1 [Schwartz, Richard Bruce; Reynolds, Bradford Zahner; Shiver, Stephen A.; Lerner, E. Brooke; Greenfield, Eric Mark; Solis, Ricaurte A.; Kimpel, Nicholas A.; Coule, Phillip L.] Med Coll Georgia, Dept Emergency Med, Augusta, GA 30912 USA.
[McManus, John G.] Brooke Army Med Ctr, San Antonio, TX USA.
RP Reynolds, BZ (reprint author), Med Coll Georgia, Dept Emergency Med, 1120 15th St,Bldg AF, Augusta, GA 30912 USA.
EM breynolds@mcg.edu
FU HemCon Inc.; Tigard; Oregon
FX Supported by HemCon Inc., Tigard, Oregon. HemCon Inc. had no control
over the study data, analysis, or interpretation, and took no part in
the writing of the study. The authors of this study have no financial
interest in HemCon Inc.
NR 27
TC 13
Z9 14
U1 1
U2 15
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1090-3127
J9 PREHOSP EMERG CARE
JI Prehosp. Emerg. Care
PD OCT-DEC
PY 2011
VL 15
IS 4
BP 477
EP 482
DI 10.3109/10903127.2011.598615
PG 6
WC Emergency Medicine; Public, Environmental & Occupational Health
SC Emergency Medicine; Public, Environmental & Occupational Health
GA 812ZG
UT WOS:000294333500004
PM 21870945
ER
PT J
AU Fernandez, JP
Barrowes, BE
Grzegorczyk, TM
Lhomme, N
O'Neill, K
Shubitidze, F
AF Fernandez, Juan Pablo
Barrowes, Benjamin E.
Grzegorczyk, Tomasz M.
Lhomme, Nicolas
O'Neill, Kevin
Shubitidze, Fridon
TI A Man-Portable Vector Sensor for Identification of Unexploded Ordnance
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Electromagnetic induction (EMI); man-portable vector (MPV) sensor;
unexploded ordnance (UXO)
ID EQUIVALENT DIPOLE POLARIZABILITIES; ELECTROMAGNETIC INDUCTION;
DISCRIMINATION; EXCITATION; TARGETS; OBJECTS; MODEL
AB The identification and discrimination of unexploded ordnance using low-frequency electromagnetic induction is an expensive and difficult process, typically beset by low data diversity and high positioning uncertainty. In this paper, we present the Man-Portable Vector (MPV) sensor, a new time-domain instrument designed to remedy these shortcomings by measuring all three vector components of the secondary magnetic field at five distinct points around each transmitter location. The MPV also has a laser positioning system that can give its location with millimeter precision. After describing the instrument in detail, we study its performance in various sets of measurements, using the tensor dipole model to analyze the data. We find that the sensor can detect deeply buried targets and identify some standard ordnance items. It can also resolve separate targets in cases where two objects share the field of view and produce overlapping signals. A new incarnation of the MPV, the MPV-II, is in an advanced stage of development.
C1 [Barrowes, Benjamin E.; O'Neill, Kevin] US Army Corps Engineers, ERDC CRREL, Hanover, NH 03755 USA.
[Grzegorczyk, Tomasz M.] Delpsi LLC, Newton, MA 02458 USA.
[Lhomme, Nicolas] Sky Res Inc, Vancouver, BC V6T 1Z3, Canada.
[Shubitidze, Fridon] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
RP Fernandez, JP (reprint author), 88 Franklin St,Unit 301, Lynn, MA 01902 USA.
EM jpf@alumni.umass.edu
FU U.S. Army Corps of Engineers, Engineer Research and Development Center;
Strategic Environmental Research and Development Program [MM-1443,
MM-1537, MM-1637]; Environmental Security Technology Certification
Program [MR-201005]
FX Manuscript received November 23, 2010; revised January 28, 2011;
accepted February 15, 2011. Date of publication February 22, 2011; date
of current version August 24, 2011. This work was supported in part by
the U.S. Army Corps of Engineers, Engineer Research and Development
Center UXO EQ/I program, in part by the Strategic Environmental Research
and Development Program, Projects MM-1443, MM-1537, and MM-1637, and in
part by the Environmental Security Technology Certification Program,
Project MR-201005. The associate editor coordinating the review of this
manuscript and approving it for publication was Dr. Patrick Ruther.
NR 62
TC 15
Z9 15
U1 0
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD OCT
PY 2011
VL 11
IS 10
BP 2542
EP 2555
DI 10.1109/JSEN.2011.2118200
PG 14
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 811AX
UT WOS:000294175000004
ER
PT J
AU Mei, YH
Lu, GQ
Chen, X
Gang, C
Luo, SF
Ibitayo, D
AF Mei, Yunhui
Lu, Guo-Quan
Chen, Xu
Gang, Chen
Luo, Shufang
Ibitayo, Dimeji
TI Investigation of Post-Etch Copper Residue on Direct Bonded Copper (DBC)
Substrates
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE DBC; copper; migration; post-etch residue; nanosilver; reliability
ID DIE-ATTACH MATERIAL; SILVER MIGRATION; OXALIC-ACID; DENDRITES;
ELECTROMIGRATION; RELIABILITY; GROWTH; FILMS; CONDUCTORS
AB For many years, direct bonded copper (DBC) substrates have proved to be an excellent solution for electrical isolation and thermal management of high-power semiconductor modules. However, in this study we detected a copper residue on the surface of DBC alumina, presumably a result of pattern etching even in industry. As is known, growth of metal dendrites could be observed with the assistance of electric field, temperature, and humidity. Metal dendrites normally grow from the cathode to anode. Silver and copper are two kinds of metals susceptible to migration. In this work, copper dendrites could be formed at 400A degrees C and 50 V/mm between conductors. These dendrites may impact the reliability of DBC in power electronic applications. Therefore, the formation of copper residue is an interesting phenomenon for etched DBC and warrants further attention in the future.
C1 [Mei, Yunhui] Tianjin Univ, Tianjin Key Lab Adv Joining Technol, Tianjin 300072, Peoples R China.
[Mei, Yunhui] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China.
[Lu, Guo-Quan] Virginia Tech, Dept Mat Sci & Engn, Blacksburg, VA USA.
[Lu, Guo-Quan] Virginia Tech, Bradley Dept Elect & Comp Engn, Blacksburg, VA USA.
[Chen, Xu; Gang, Chen] Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R China.
[Luo, Shufang] NBE Technol LLC, Blacksburg, VA 24061 USA.
[Ibitayo, Dimeji] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD USA.
RP Mei, YH (reprint author), Tianjin Univ, Tianjin Key Lab Adv Joining Technol, Tianjin 300072, Peoples R China.
EM yunhui@tju.edu.cn
RI Chen, Xu/A-8487-2008; Lu, Guo-Quan/N-3661-2013; Mei, Yunhui/N-1095-2013
OI Mei, Yunhui/0000-0002-6508-4343
NR 27
TC 14
Z9 14
U1 2
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD OCT
PY 2011
VL 40
IS 10
BP 2119
EP 2125
DI 10.1007/s11664-011-1716-8
PG 7
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA 809OA
UT WOS:000294065400010
ER
PT J
AU Thompson, SM
Hathaway, AA
Smoot, CD
Wilson, CA
Ma, HB
Young, RM
Greenberg, L
Osick, BR
Van Campen, S
Morgan, BC
Sharar, D
Jankowski, N
AF Thompson, S. M.
Hathaway, A. A.
Smoot, C. D.
Wilson, C. A.
Ma, H. B.
Young, R. M.
Greenberg, L.
Osick, B. R.
Van Campen, S.
Morgan, B. C.
Sharar, D.
Jankowski, N.
TI Robust Thermal Performance of a Flat-Plate Oscillating Heat Pipe During
High-Gravity Loading
SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
LA English
DT Article
DE oscillating/pulsating heat pipes; high gravity; flat-plate heat pipe;
effective thermal conductivity
AB The thermal performance of a miniature, three-dimensional flatplate oscillating heat pipe (3D FP-OHP) was experimentally investigated during high-gravity loading with nonfavorable evaporator positioning. The heat pipe had dimensions of 3.0 x 3.0 x 0.254 cm(3) and utilized a novel design concept incorporating a two-layer channel arrangement. The device was charged with acetone and tested at a heat input of 95 W within a spin-table centrifuge. It was found that the heat pipe operated and performed near-independent of the investigated hypergravity loading up to 10 g. Results show that at ten times the acceleration due to gravity (10 g), the effective thermal conductivity was almost constant and even slightly increased which is very different from a conventional heat pipe. The gravity-independent heat transfer performance provides a unique feature of OHPs. [DOI: 10.1115/1.4004076]
C1 [Thompson, S. M.; Hathaway, A. A.; Smoot, C. D.; Wilson, C. A.; Ma, H. B.] Univ Missouri, Dept Mech & Aerosp Engn, Columbia, MO 65211 USA.
[Young, R. M.; Greenberg, L.; Osick, B. R.; Van Campen, S.] Northrop Grumman Corp, Linthicum, MD 21090 USA.
[Morgan, B. C.; Sharar, D.; Jankowski, N.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Ma, HB (reprint author), Univ Missouri, Dept Mech & Aerosp Engn, Columbia, MO 65211 USA.
OI Thompson, Scott M./0000-0002-8807-1430; Young, Ross/0000-0002-6806-6503
FU DARPA
FX The work presented in this article was supported by the DARPA TGP
program under the direction of Dr. Tom Kenny.
NR 17
TC 14
Z9 14
U1 0
U2 14
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0022-1481
J9 J HEAT TRANS-T ASME
JI J. Heat Transf.-Trans. ASME
PD OCT
PY 2011
VL 133
IS 10
AR 104504
DI 10.1115/1.4004076
PG 5
WC Thermodynamics; Engineering, Mechanical
SC Thermodynamics; Engineering
GA 811LG
UT WOS:000294211000019
ER
PT J
AU Liu, QL
Subhash, G
Moore, DF
AF Liu, Qunli
Subhash, Ghatu
Moore, David F.
TI Loading velocity dependent permeability in agarose gel under compression
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Agarose gel; Permeability; Viscoelasticity; Equilibrium response;
Loading velocity
ID ARTICULAR-CARTILAGE; HYDRAULIC PERMEABILITY; MECHANICAL-PROPERTIES;
STRESS-RELAXATION; WATER-STRUCTURE; HYDROGELS; BEHAVIOR; H-1-NMR;
INSIGHT; STATES
AB A new approach for characterization of agarose gel permeability under compression at different loading velocities is proposed. Uniaxial compression tests on thin agarose gel specimens in a rigid porous confinement cell immersed in a water bath are undertaken. The equilibrium response of the gel, which is assumed to be achieved under extremely low-loading velocity (of the order of tens nanometers per second) is considered to be the response of the hydrated gel scaffold. The water exudation behavior from the agarose gel was extracted from the load-displacement response under various loading velocities by subtracting the equilibrium response. It was found that the pressure on water in the gel is not a linear function of loading velocity or volume flow rate and therefore, the permeability of agarose gel was observed to vary with deformation and water flow velocity. In addition, it was inferred from the analysis that at low velocities and large strain levels the gel permeability dominates the compression behavior, and at higher velocities and small strain levels the viscosity of the hydrated matrix may contribute to the load. Finally, permeability variation in agarose gel at different loading velocities is attributed to the two states (free water and bound water) of water molecules in the gel. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Liu, Qunli; Subhash, Ghatu] Univ Florida, Dept Mech & Aerosp, Gainesville, FL 32611 USA.
[Liu, Qunli] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA.
[Moore, David F.] Tulane Univ, Dept Neurol, New Orleans, LA 70112 USA.
RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp, Gainesville, FL 32611 USA.
EM subhash@ufl.edu
FU Congressional Directed Medical Research Program Fellowship on Traumatic
Brain Injury [W81XWH-08-1-0688]
FX Qunli Liu sincerely acknowledges support from Congressional Directed
Medical Research Program Fellowship on Traumatic Brain Injury Contract
W81XWH-08-1-0688.
NR 34
TC 3
Z9 3
U1 5
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD OCT
PY 2011
VL 4
IS 7
BP 974
EP 982
DI 10.1016/j.jmbbm.2011.02.009
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 811EX
UT WOS:000294187500007
PM 21783107
ER
PT J
AU Prabhu, R
Horstemeyer, MF
Tucker, MT
Marin, EB
Bouvard, JL
Sherburn, JA
Liao, J
Williams, LN
AF Prabhu, R.
Horstemeyer, M. F.
Tucker, M. T.
Marin, E. B.
Bouvard, J. L.
Sherburn, J. A.
Liao, Jun
Williams, Lakiesha N.
TI Coupled experiment/finite element analysis on the mechanical response of
porcine brain under high strain rates
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Porcine brain; Mechanical behavior; Strain rate effects; Stress state;
SHPB; Finite element analysis
ID HOPKINSON PRESSURE BAR; WHITE-MATTER; INJURY; MODEL; DEFORMATION;
COMPRESSION; BEHAVIOR; STRETCH; SYSTEM
AB This paper presents a coupled experimental/modeling study of the mechanical response of porcine brain under high strain rate loading conditions. Essentially, the stress wave propagation through the brain tissue is quantified. A Split-Hopkinson Pressure Bar (SPHB) apparatus, using a polycarbonate (viscoelastic) striker bar was employed for inducing compression waves for strain rates ranging from 50 to 750 s(-1). The experimental responses along with high speed video showed that the brain tissue's response was nonlinear and inelastic. Also, Finite Element Analysis (FEA) of the SHPB tests revealed that the tissue underwent a non-uniform stress state during testing when glue is used to secure the specimen with the test fixture. This result renders erroneous the assumption of uniaxial loading. In this study, the uniaxial volume averaged stress-strain behavior was extracted from the FEA to help calibrate inelastic constitutive equations. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Prabhu, R.; Horstemeyer, M. F.; Marin, E. B.; Bouvard, J. L.; Liao, Jun; Williams, Lakiesha N.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39759 USA.
[Prabhu, R.; Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA.
[Tucker, M. T.] Los Alamos Natl Lab, Grp MST 8, Los Alamos, NM 87545 USA.
[Sherburn, J. A.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Liao, Jun; Williams, Lakiesha N.] Mississippi State Univ, Agr & Biol Engn Dept, Mississippi State, MS 39762 USA.
RP Williams, LN (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39759 USA.
EM lwilliams@abe.msstate.edu
OI Horstemeyer, Mark/0000-0003-4230-0063
FU Center for Advanced Vehicular Systems (CAVS); Agricultural and
Biological Engineering Department at the Mississippi State University;
US Army TACOM Life Cycle Command through a subcontract with the
Mississippi State University [W56HZV-08-C-0236]; National Nuclear
Security Administration (Department of Energy) [IDE-FC26-06NT427551]
FX The authors would like to thank the Center for Advanced Vehicular
Systems (CAVS) and the Agricultural and Biological Engineering
Department at the Mississippi State University for supporting this work.
This material is based upon the work supported by the US Army TACOM Life
Cycle Command under Contract No. W56HZV-08-C-0236, through a subcontract
with the Mississippi State University, and was performed for the
Simulation Based Reliability and Safety (SimBRS) research program. Also,
this material is based upon the work supported by the National Nuclear
Security Administration (Department of Energy) under award number
IDE-FC26-06NT427551. Finally, the authors would like to thank David
Adams, Michael McCollum and Wilburn Whittington for their effort in this
research.
NR 31
TC 10
Z9 10
U1 3
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD OCT
PY 2011
VL 4
IS 7
BP 1067
EP 1080
DI 10.1016/j.jmbbm.2011.03.015
PG 14
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 811EX
UT WOS:000294187500016
PM 21783116
ER
PT J
AU Paul, RK
Badhulika, S
Niyogi, S
Haddon, RC
Boddu, VM
Costales-Nieves, C
Bozhilov, KN
Mulchandani, A
AF Paul, Rajat K.
Badhulika, Sushmee
Niyogi, Sandip
Haddon, Robert C.
Boddu, Veera M.
Costales-Nieves, Carmen
Bozhilov, Krassimir N.
Mulchandani, Ashok
TI The production of oxygenated polycrystalline graphene by one-step
ethanol-chemical vapor deposition
SO CARBON
LA English
DT Article
ID CARBON; FILMS; TRANSPARENT; SPECTROSCOPY; NANORIBBONS; ELECTRODES;
AMMONIA; BULK
AB Large-area mono- and bilayer graphene films were synthesized on Cu foil (similar to 1 in.(2)) in about 1 min by a simple ethanol-chemical vapor deposition (CVD) technique. Raman spectroscopy and high resolution transmission electron microscopy revealed the synthesized graphene films to have polycrystalline structures with 2-5 nm individual crystallite size which is a function of temperature up to 1000 degrees C. X-ray photoelectron spectroscopy investigations showed about 3 at.% carboxylic (COOH) functional groups were formed during growth. The field-effect transistor devices fabricated using polycrystalline graphene as conducting channel (L(c) = 10 mu m; W(c) = 50 mu m) demonstrated a p-type semiconducting behavior with high drive current and Dirac point at similar to 35 V. This simple one-step method of growing large area polycrystalline graphene films with semiconductor properties and easily functionalizable groups should assist in the realization of potential of polycrystalline graphene for nanoelectronics, sensors and energy storage devices. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Paul, Rajat K.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
[Paul, Rajat K.; Badhulika, Sushmee] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA.
[Niyogi, Sandip; Haddon, Robert C.] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA.
[Niyogi, Sandip; Haddon, Robert C.; Mulchandani, Ashok] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA.
[Haddon, Robert C.; Mulchandani, Ashok] Univ Calif Riverside, Ctr Nanoscale Sci & Engn, Riverside, CA 92521 USA.
[Bozhilov, Krassimir N.] Univ Calif Riverside, Cent Facil Adv Microscopy & Microanal, Riverside, CA 92521 USA.
[Boddu, Veera M.; Costales-Nieves, Carmen] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
RP Paul, RK (reprint author), Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
EM rpaul003@ucr.edu; adani@engr.ucr.edu
RI Haddon, Robert/A-2528-2008; Mulchandani, Ashok/B-9692-2016
OI Haddon, Robert/0000-0002-7903-5139; Mulchandani,
Ashok/0000-0002-2831-4154
FU National Institutes of Health [U01ES016026]; US Department of Energy
[DE-FG02-07ER46453, DE-FG02-07ER46471]; Dean of Bourns College of
Engineering at the University of California, Riverside
FX We acknowledge the financial support from the Dean of Bourns College of
Engineering at the University of California, Riverside and the National
Institutes of Health Grant U01ES016026. Part of the characterization
work was carried out in the Frederick Seitz Materials Research
Laboratory Central Facilities, University of Illinois, which are
partially supported by the US Department of Energy under Grants
DE-FG02-07ER46453 and DE-FG02-07ER46471.
NR 33
TC 14
Z9 14
U1 0
U2 43
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-6223
J9 CARBON
JI Carbon
PD OCT
PY 2011
VL 49
IS 12
BP 3789
EP 3795
DI 10.1016/j.carbon.2011.04.070
PG 7
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA 809DD
UT WOS:000294031100011
PM 22408276
ER
PT J
AU Hsu, MC
Akkerman, I
Bazilevs, Y
AF Hsu, Ming-Chen
Akkerman, Ido
Bazilevs, Yuri
TI High-performance computing of wind turbine aerodynamics using
isogeometric analysis
SO COMPUTERS & FLUIDS
LA English
DT Article
DE Wind turbine; RBVMS; Turbulence modeling; Isogeometric analysis; NURBS;
High-performance computing; Parallel scalability
ID FLUID-STRUCTURE INTERACTION; VARIATIONAL MULTISCALE METHOD; DIRICHLET
BOUNDARY-CONDITIONS; NAVIER-STOKES EQUATIONS; LARGE-EDDY SIMULATION;
TURBULENT FLOWS; INCOMPRESSIBLE FLOWS; NUMERICAL-SIMULATION; STABILIZED
METHODS; 3D SIMULATION
AB In this article we present a high-performance computing framework for advanced flow simulation and its application to wind energy based on the residual-based variational multiscale (RBVMS) method and isogeometric analysis. The RBVMS formulation and its suitability and accuracy for turbulent flow in a moving domain are presented. Particular emphasis is placed on the parallel implementation of the methodology and its scalability. Two challenging flow cases were considered: the turbulent Taylor-Couette flow and the NREL 5 MW offshore baseline wind turbine rotor at full scale. In both cases, flow quantities of interest from the simulation results compare favorably with the reference data and near-perfect linear parallel scaling is achieved. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Hsu, Ming-Chen; Akkerman, Ido; Bazilevs, Yuri] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92093 USA.
[Akkerman, Ido] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Hsu, MC (reprint author), Univ Calif San Diego, Dept Struct Engn, 9500 Gilman Dr,Mail Code 0085, La Jolla, CA 92093 USA.
EM m5hsu@ucsd.edu
RI Akkerman, Ido/H-9957-2012; Hsu, Ming-Chen/J-1881-2012
OI Hsu, Ming-Chen/0000-0001-8062-8612
NR 65
TC 35
Z9 37
U1 2
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-7930
EI 1879-0747
J9 COMPUT FLUIDS
JI Comput. Fluids
PD OCT
PY 2011
VL 49
IS 1
BP 93
EP 100
DI 10.1016/j.compfluid.2011.05.002
PG 8
WC Computer Science, Interdisciplinary Applications; Mechanics
SC Computer Science; Mechanics
GA 807ZH
UT WOS:000293941100008
ER
PT J
AU Hilton, CD
Peairs, DM
Lesko, JJ
Case, SW
AF Hilton, Corydon D.
Peairs, Daniel M.
Lesko, John J.
Case, Scott W.
TI A Metric for Characterization of Multifunctional Fuel Cell Designs
SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY
LA English
DT Article
DE multifunctional; composite; fuel cell; characterization
ID TRANSVERSELY FLEXIBLE CORE; LAMINATED COMPOSITE SKINS; SANDWICH BEAMS;
ORDER THEORY; BEHAVIOR
AB The U.S. Army has investigated a variety of multifunctional designs in order to achieve system level mass and/or volume savings. One of the multifunctional devices developed is the multifunctional fuel cell (MFC)-a fuel cell which simultaneously provides a system with structural support and power generation. However, there are no established methods for measuring how well a particular design performs or its multifunctional advantage. The current paper presents a metric by which multifunctional fuel cell designs can be characterized. The mechanical aspect of the metric is based on the specific bending stiffness of the structural cell and is developed using Frostig's high-order theory. The electrical component of the metric is based on the specific power density achieved by the structural cell. The structural systems considered here display multifunctional efficiencies ranging from 22% to 69%. The higher efficiency was obtained by optimizing the contact pressure at the gas diffusion layer (GDL) in a model cell design. The efficiencies obtained suggest the need for improved multifunctional designs in order to reach system level mass savings. [DOI: 10.1115/1.4003760]
C1 [Hilton, Corydon D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Peairs, Daniel M.] Luna Innovat Inc, Blacksburg, VA 24060 USA.
[Lesko, John J.] Virginia Tech VPT Energy Syst, Blacksburg, VA 24060 USA.
[Case, Scott W.] Virginia Tech, Blacksburg, VA 24061 USA.
RP Hilton, CD (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM cdhilton@vt.edu; peairsd@lunainnovations.com; jlesko@vpt-es.com;
scase@vt.edu
RI Case, Scott/C-2637-2009
FU Army Research Laboratory [W911NF-06-2-0014]
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-06-2-0014. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon.
NR 24
TC 1
Z9 1
U1 1
U2 3
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1550-624X
J9 J FUEL CELL SCI TECH
JI J. Fuel Cell Sci. Technol.
PD OCT
PY 2011
VL 8
IS 5
AR 051008
DI 10.1115/1.4003760
PG 7
GA 791XG
UT WOS:000292701800008
ER
PT J
AU Okinaka, RT
Price, EP
Wolken, SR
Gruendike, JM
Chung, WK
Pearson, T
Xie, G
Munk, C
Hill, KK
Challacombe, J
Ivins, BE
Schupp, JM
Beckstrom-Sternberg, SM
Friedlander, A
Keim, P
AF Okinaka, Richard T.
Price, Erin P.
Wolken, Spenser R.
Gruendike, Jeffrey M.
Chung, Wai Kwan
Pearson, Talima
Xie, Gary
Munk, Chris
Hill, Karen K.
Challacombe, Jean
Ivins, Bruce E.
Schupp, James M.
Beckstrom-Sternberg, Stephen M.
Friedlander, Arthur
Keim, Paul
TI An attenuated strain of Bacillus anthracis (CDC 684) has a large
chromosomal inversion and altered growth kinetics
SO BMC GENOMICS
LA English
DT Article
ID PROTECTIVE ANTIGEN GENE; ESCHERICHIA-COLI; INHALATION ANTHRAX;
MOLECULAR-CLONING; TOXIN GENES; REPLICATION; EXPRESSION; SEQUENCE;
CEREUS; RECOMBINATION
AB Background: An isolate originally labeled Bacillus megaterium CDC 684 was found to contain both pXO1 and pXO2, was non-hemolytic, sensitive to gamma-phage, and produced both the protective antigen and the poly-D-glutamic acid capsule. These phenotypes prompted Ezzell et al., (J. Clin. Microbiol. 28:223) to reclassify this isolate to Bacillus anthracis in 1990.
Results: We demonstrate that despite these B. anthracis features, the isolate is severely attenuated in a guinea pig model. This prompted whole genome sequencing and closure. The comparative analysis of CDC 684 to other sequenced B. anthracis isolates and further analysis reveals: a) CDC 684 is a close relative of a virulent strain, Vollum A0488; b) CDC 684 defines a new B. anthracis lineage (at least 51 SNPs) that includes 15 other isolates; c) the genome of CDC 684 contains a large chromosomal inversion that spans 3.3 Mbp; d) this inversion has caused a displacement of the usual spatial orientation of the origin of replication (ori) to the termination of replication (ter) from 180 degrees in wild-type B. anthracis to 120 degrees in CDC 684 and e) this isolate also has altered growth kinetics in liquid media.
Conclusions: We propose two alternative hypotheses explaining the attenuated phenotype of this isolate. Hypothesis 1 suggests that the skewed ori/ter relationship in CDC 684 has altered its DNA replication and/or transcriptome processes resulting in altered growth kinetics and virulence capacity. Hypothesis 2 suggests that one or more of the single nucleotide polymorphisms in CDC 684 has altered the expression of a regulatory element or other genes necessary for virulence.
C1 [Okinaka, Richard T.; Price, Erin P.; Wolken, Spenser R.; Gruendike, Jeffrey M.; Chung, Wai Kwan; Pearson, Talima; Beckstrom-Sternberg, Stephen M.; Keim, Paul] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
[Okinaka, Richard T.; Xie, Gary; Munk, Chris; Hill, Karen K.; Challacombe, Jean; Keim, Paul] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA.
[Ivins, Bruce E.; Friedlander, Arthur] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
[Schupp, James M.; Beckstrom-Sternberg, Stephen M.; Keim, Paul] Translat Genom Res Inst, Pathogen Genom Div, Phoenix, AZ 85004 USA.
RP Okinaka, RT (reprint author), No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
EM Richard.Okinaka@nau.edu
RI Keim, Paul/A-2269-2010; Price, Erin/N-2336-2013;
OI Price, Erin/0000-0002-1079-4882; xie, gary/0000-0002-9176-924X
FU Department of Homeland Security Science and Technology Directorate
[NBCH2070001, HSHQDC-08-C00158]; NAU's Technology and Research
Initiative Fund
FX This work was funded in part by the Department of Homeland Security
Science and Technology Directorate under contract numbers: NBCH2070001
and HSHQDC-08-C00158. Support for this project was also provide by NAU's
Technology and Research Initiative Fund.
NR 51
TC 11
Z9 11
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD SEP 30
PY 2011
VL 12
AR 477
DI 10.1186/1471-2164-12-477
PG 13
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 844RW
UT WOS:000296766000001
PM 21962024
ER
PT J
AU Kim, HS
Lo, SC
Wear, DJ
Stojadinovic, A
Weina, PJ
Izadjoo, MJ
AF Kim, Ho San
Lo, Shyh-Ching
Wear, Douglas J.
Stojadinovic, Alexander
Weina, Peter J.
Izadjoo, Mina J.
TI Improvement of anti-Burkholderia mouse monoclonal antibody from variou:
phage-displayed single-chain antibody libraries
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE Phage-displayed mouse scFv random and domain libraries; Burkholderia
bacteria; Oligonucleotide-directed mutagenesis; Random mutagenesis;
Chimeric MAb
ID AFFINITY MATURATION; VARIABLE DOMAINS; IN-VITRO; PSEUDOMALLEI;
SELECTION; MALLEI; CONSTRUCTION; POLYMERASE; FIDELITY
AB To improve anti-Burkholderia monoclonal antibody (MAb) binding affinity, six single chair variable fragments (scFvs) constructed previously were used as scaffolds to construct large highly-diversified phage-displayed mouse scFv random and domain libraries. First, we employed random mutagenesis to introduce random point mutations into entire variable regions, generating six random libraries. Additionally, the oligonucleotide-directed mutagenesis was targeted on complementarity-determining region 3 (CDR3) from each variable region of heavy (VH) and light chains (VL) derived from six scFvs, and generated eighteen domain libraries including six VH CDR3, six VL CDR3, and six combined VH/VL CDR3 mutated domains respectively. We collected high scFvs binders through panning experiment over the large (size similar to 1 x 10(9)) random and domain libraries. The quality of the libraries was validated by successful selection of high-affinity clones. Random mutagenesis generated many mutant scFv clones having more than one amino acid changes around framework regions, but not many in CDRs. Surprisingly, the resulting eight higher scFv binders were selected from CDR3 mutations, but not from random mutations. Six of them resulted from CDR3 mutations of light chain, except for two scFvs from heavy chain, showing both Burkholderia pseudomallei and Burkholderia mallei had preferentially influenced the VL CDR3. Furthermore, all eight higher scFvs converted to full format human IgC1 antibodies were expressed transiently in 293T cell line. Five chimeric MAbs showed improved higher binding activity, as much as 0.2-0.3 at O.D. 405 nm, than positive control MAbs. These libraries could be valuable sources for selection of anti-Burkholderia antibodies and discovery of the relevant epitope(s) for developing effective vaccines or therapeutics. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kim, Ho San; Lo, Shyh-Ching; Wear, Douglas J.; Izadjoo, Mina J.] AFIP, Washington, DC 20306 USA.
[Kim, Ho San; Lo, Shyh-Ching; Wear, Douglas J.; Izadjoo, Mina J.] Amer Registry Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA.
[Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20306 USA.
[Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Izadjoo, MJ (reprint author), AFIP, Bldg 54,Room 4307,6825 16th St NW, Washington, DC 20306 USA.
EM mjizadjoo@yahoo.com
RI Weina, Peter/A-2120-2011
FU Defense Threat Reduction Agency [JSTO-CDB/DTRA2.1_07_AF_B]
FX This work is supported by a Defense Threat Reduction Agency grant
(JSTO-CDB/DTRA2.1_07_AF_B).
NR 23
TC 3
Z9 4
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD SEP 30
PY 2011
VL 372
IS 1-2
BP 146
EP 161
DI 10.1016/j.jim.2011.07.009
PG 16
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA 831WV
UT WOS:000295762700017
PM 21787781
ER
PT J
AU Oliver, AJ
Hong-Wa, C
Devonshire, J
Olea, KR
Rivas, GF
Gahl, MK
AF Oliver, Amanda J.
Hong-Wa, Cynthia
Devonshire, Jodi
Olea, Kelly R.
Rivas, Gonzalo F.
Gahl, Megan K.
TI Avifauna richness enhanced in large, isolated urban parks
SO LANDSCAPE AND URBAN PLANNING
LA English
DT Article
DE Bird species richness; Island biogeography; Mississippi flyway; Species
composition; Urbanization
ID PLANT-SPECIES RICHNESS; AREA PER-SE; BIRD COMMUNITY; HABITAT DIVERSITY;
LANDSCAPE DIVERSITY; FOREST PATCHES; URBANIZATION; CONSERVATION;
ASSEMBLAGES; ISLANDS
AB Urbanization causes fragmentation creating "islands" of natural habitat. The resulting fragmented landscapes represent a challenge for migratory and resident species because of decreased connectivity among fragments. We examined the effects of urbanization on avifauna communities in remnant and restored parks in the greater St. Louis area (St. Louis), Missouri and Illinois, USA. St. Louis is located along the Mississippi flyway, a significant North American migratory bird route, and ranks second among the most sprawl-threatened large cities. We compiled bird assemblages for 20 parks and used multiple linear regressions and Akaike's Information Criterion (AIC) to analyze seven potential predictors of species richness for breeding, migratory and wintering species: area, habitat diversity, external development within 1 km and 5 km buffers, internal developed areas, road length, and presence of water bodies. The best predictors of resident bird (i.e., breeding and wintering) species richness was park area and external developed area within 5 km, a surrogate for isolation. We suspect that the high species richness in parks in heavily urbanized areas is explained by the parks' relatively large size and the funneling of species to two large parks within the most urbanized areas of St. Louis. For migratory species, the best predictors were habitat diversity and developed area within the park. As development continues to transform natural habitat along important avian migratory flyways, urban planning that includes large, diverse natural areas within urbanized landscapes is key to conserving local and migratory avifauna diversity. Published by Elsevier B.V.
C1 [Oliver, Amanda J.] US Army Corps Engineers, Environm Branch, St Louis, MO 63103 USA.
[Oliver, Amanda J.; Hong-Wa, Cynthia; Olea, Kelly R.; Rivas, Gonzalo F.; Gahl, Megan K.] Univ Missouri, Dept Biol, St Louis, MO 63121 USA.
[Devonshire, Jodi] Univ Missouri, RCEW, St Louis, MO 63121 USA.
RP Oliver, AJ (reprint author), US Army Corps Engineers, Environm Branch, 1222 Spruce St, St Louis, MO 63103 USA.
EM amanda.j.oliver@usace.army.mil; chvc4@umsl.edu;
jodidevonshire@gmail.com; kro8r4@umsl.edu; gfrhw9@umsl.edu;
mkgahl@gmail.com
NR 53
TC 19
Z9 20
U1 3
U2 92
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-2046
J9 LANDSCAPE URBAN PLAN
JI Landsc. Urban Plan.
PD SEP 30
PY 2011
VL 102
IS 4
BP 215
EP 225
DI 10.1016/j.landurbplan.2011.04.007
PG 11
WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban
Studies
SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban
Studies
GA 825RI
UT WOS:000295299400003
ER
PT J
AU Filippov, AA
Sergueev, KV
He, YX
Huang, XZ
Gnade, BT
Mueller, AJ
Fernandez-Prada, CM
Nikolich, MP
AF Filippov, Andrey A.
Sergueev, Kirill V.
He, Yunxiu
Huang, Xiao-Zhe
Gnade, Bryan T.
Mueller, Allen J.
Fernandez-Prada, Carmen M.
Nikolich, Mikeljon P.
TI Bacteriophage-Resistant Mutants in Yersinia pestis: Identification of
Phage Receptors and Attenuation for Mice
SO PLOS ONE
LA English
DT Article
ID GENERALIZED TRANSDUCING PHAGE; LIPOPOLYSACCHARIDE OUTER CORE;
ESCHERICHIA-COLI DIARRHEA; PASTEURELLA-PESTIS; GENOME SEQUENCE;
ANTIMICROBIAL PEPTIDES; NUCLEOTIDE-SEQUENCE; PNEUMONIC PLAGUE; BUBONIC
PLAGUE; PLATING MEDIUM
AB Background: Bacteriophages specific for Yersinia pestis are routinely used for plague diagnostics and could be an alternative to antibiotics in case of drug-resistant plague. A major concern of bacteriophage therapy is the emergence of phage-resistant mutants. The use of phage cocktails can overcome this problem but only if the phages exploit different receptors. Some phage-resistant mutants lose virulence and therefore should not complicate bacteriophage therapy.
Methodology/Principal Findings: The purpose of this work was to identify Y. pestis phage receptors using site-directed mutagenesis and trans-complementation and to determine potential attenuation of phage-resistant mutants for mice. Six receptors for eight phages were found in different parts of the lipopolysaccharide (LPS) inner and outer core. The receptor for R phage was localized beyond the LPS core. Most spontaneous and defined phage-resistant mutants of Y. pestis were attenuated, showing increase in LD(50) and time to death. The loss of different LPS core biosynthesis enzymes resulted in the reduction of Y. pestis virulence and there was a correlation between the degree of core truncation and the impact on virulence. The yrbH and waaA mutants completely lost their virulence.
Conclusions/Significance: We identified Y. pestis receptors for eight bacteriophages. Nine phages together use at least seven different Y. pestis receptors that makes some of them promising for formulation of plague therapeutic cocktails. Most phage-resistant Y. pestis mutants become attenuated and thus should not pose a serious problem for bacteriophage therapy of plague. LPS is a critical virulence factor of Y. pestis.
C1 [Filippov, Andrey A.; Sergueev, Kirill V.; He, Yunxiu; Huang, Xiao-Zhe; Gnade, Bryan T.; Mueller, Allen J.; Fernandez-Prada, Carmen M.; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Emerging Bacterial Infect, Silver Spring, MD 20910 USA.
RP Filippov, AA (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Emerging Bacterial Infect, Silver Spring, MD 20910 USA.
EM andrey.filippov@amedd.army.mil
FU Defense Threat Reduction Agency, Joint Science and Technology Office,
Medical ST Division [2.10052_08_WR_B]
FX This research was supported by the Defense Threat Reduction Agency,
Joint Science and Technology Office, Medical S&T Division
(http://www.dtra.mil/Research.aspx), grant #2.10052_08_WR_B. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 95
TC 32
Z9 36
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2011
VL 6
IS 9
AR e25486
DI 10.1371/journal.pone.0025486
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 834CT
UT WOS:000295936900072
PM 21980477
ER
PT J
AU Mita, AC
Papadopoulos, K
de Jonge, MJA
Schwartz, G
Verweij, J
Mita, MM
Ricart, A
Chu, QC
Tolcher, AW
Wood, L
McCarthy, S
Hamilton, M
Iwata, K
Wacker, B
Witt, K
Rowinsky, EK
AF Mita, A. C.
Papadopoulos, K.
de Jonge, M. J. A.
Schwartz, G.
Verweij, J.
Mita, M. M.
Ricart, A.
Chu, Qs-C
Tolcher, A. W.
Wood, L.
McCarthy, S.
Hamilton, M.
Iwata, K.
Wacker, B.
Witt, K.
Rowinsky, E. K.
TI Erlotinib 'dosing-to-rash': a phase II intrapatient dose escalation and
pharmacologic study of erlotinib in previously treated advanced
non-small cell lung cancer
SO BRITISH JOURNAL OF CANCER
LA English
DT Article
DE erlotinib; non-small cell lung cancer; EGFR; skin rash
ID GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITOR; COLORECTAL-CANCER;
CLINICAL-TRIALS; CHEMOTHERAPY; CETUXIMAB; RECURRENT; OSI-774;
MULTICENTER; CARCINOMA
AB BACKGROUND: To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of higher doses of erlotinib.
METHODS: Patients initially received erlotinib 150 mg per day. The dose was successively increased in each patient to that associated with a TR. Anticancer activity was evaluated. Plasma, skin, and hair were sampled for PK and PD studies.
RESULTS: Erlotinib dose escalation to 200-475 mg per day was feasible in 38 (90%) of 42 patients. Twenty-four (57%) patients developed a TR, but 19 (79%) did so at 150 mg per day. Five (12%) patients, all of whom developed a TR, had a partial response. Median progression-free survival (PFS) was 2.3 months (95% CI: 1.61, 4.14); median PFS was 3.5 months and 1.9 months, respectively, for patients who did and did not experience a TR (hazard ratio, 0.51; P = 0.051). Neither rash severity nor response correlated with erlotinib exposure.
CONCLUSION: Intrapatient dose escalation of erlotinib does not appreciably increase the propensity to experience a maximal level of tolerable skin toxicity, or appear to increase the anticancer activity of erlotinib in NSCLC. British Journal of Cancer (2011) 105, 938-944. doi:10.1038/bjc.2011.332 www.bjcancer.com Published online 30 August 2011 (C) 2011 Cancer Research UK
C1 [Papadopoulos, K.; Mita, M. M.; Ricart, A.; Chu, Qs-C; Tolcher, A. W.; Wood, L.; Rowinsky, E. K.] Univ Texas Hlth Sci Ctr San Antonio, Inst Drug Dev, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA.
[de Jonge, M. J. A.; Verweij, J.] Erasmus Univ, Med Ctr, NL-3000 CA Rotterdam, Netherlands.
[Schwartz, G.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[McCarthy, S.; Hamilton, M.; Iwata, K.; Wacker, B.; Witt, K.] OSI Pharmaceut, Boulder, CO 80301 USA.
RP Mita, AC (reprint author), Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Phase Area 1, 8700 Beverly Blvd,Saperstein Critical Care Tower, Los Angeles, CA 90048 USA.
EM Alain.Mita@gmail.com
FU OSI Pharmaceuticals
FX We thank Mrs Aimee Tetrault and Mrs Kim Wright for their editorial
assistance. This study was funded by OSI Pharmaceuticals.
NR 30
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Z9 22
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0007-0920
J9 BRIT J CANCER
JI Br. J. Cancer
PD SEP 27
PY 2011
VL 105
IS 7
BP 938
EP 944
DI 10.1038/bjc.2011.332
PG 7
WC Oncology
SC Oncology
GA 826MI
UT WOS:000295357900011
PM 21878940
ER
PT J
AU Sheng, ZM
Chertow, DS
Ambroggio, X
McCall, S
Przygodzki, RM
Cunningham, RE
Maximova, OA
Kash, JC
Morens, DM
Taubenberger, JK
AF Sheng, Zong-Mei
Chertow, Daniel S.
Ambroggio, Xavier
McCall, Sherman
Przygodzki, Ronald M.
Cunningham, Robert E.
Maximova, Olga A.
Kash, John C.
Morens, David M.
Taubenberger, Jeffery K.
TI Autopsy series of 68 cases dying before and during the 1918 influenza
pandemic peak
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE archaevirology; postmortem; immunohistochemistry
ID ARMED-FORCES-INSTITUTE; VIRUS INFECTIONS; A VIRUSES;
BINDING-SPECIFICITY; IMMUNE-RESPONSE; HOST IMMUNE; HEMAGGLUTININ; GENE;
TRANSMISSION; PATHOGENESIS
AB The 1918 to 1919 "Spanish" influenza pandemic virus killed up to 50 million people. We report here clinical, pathological, bacteriological, and virological findings in 68 fatal American influenza/pneumonia military patients dying between May and October of 1918, a period that includes similar to 4 mo before the 1918 pandemic was recognized, and 2 mo (September-October 1918) during which it appeared and peaked. The lung tissues of 37 of these cases were positive for influenza viral antigens or viral RNA, including four from the prepandemic period (May-August). The prepandemic and pandemic peak cases were indistinguishable clinically and pathologically. All 68 cases had histological evidence of bacterial pneumonia, and 94% showed abundant bacteria on Gram stain. Sequence analysis of the viral hemagglutinin receptor-binding domain performed on RNA from 13 cases suggested a trend from a more "avian-like" viral receptor specificity with G222 in prepandemic cases to a more "human-like" specificity associated with D222 in pandemic peak cases. Viral antigen distribution in the respiratory tree, however, was not apparently different between prepandemic and pandemic peak cases, or between infections with viruses bearing different receptor-binding polymorphisms. The 1918 pandemic virus was circulating for at least 4 mo in the United States before it was recognized epidemiologically in September 1918. The causes of the unusually high mortality in the 1918 pandemic were not explained by the pathological and virological parameters examined. These findings have important implications for understanding the origins and evolution of pandemic influenza viruses.
C1 [Sheng, Zong-Mei; Chertow, Daniel S.; Kash, John C.; Taubenberger, Jeffery K.] NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
[Ambroggio, Xavier] NIAID, Bioinformat & Computat Biosci Branch, NIH, Bethesda, MD 20892 USA.
[Maximova, Olga A.] NIAID, Off Chief, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
[Morens, David M.] NIAID, Off Director, NIH, Bethesda, MD 20892 USA.
[McCall, Sherman] USA, Clin Pathol Lab, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Przygodzki, Ronald M.] Dept Vet Affairs, Washington, DC 20420 USA.
[Cunningham, Robert E.] Armed Forces Inst Pathol, Dept Biophys, Rockville, MD 20850 USA.
RP Taubenberger, JK (reprint author), NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA.
EM taubenbergerj@niaid.nih.gov
OI Przygodzki, Ronald/0000-0002-1238-262X
FU National Institutes of Health; National Institute of Allergy and
Infectious Diseases
FX We thank Frank Roberts and the repository staff of the Armed Forces
Institute of Pathology for their help in locating 1918 case material,
and Jen Hammock for assistance with the histological preparations. This
work was supported by the intramural funds of the National Institutes of
Health and the National Institute of Allergy and Infectious Diseases.
NR 52
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U1 0
U2 2
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 27
PY 2011
VL 108
IS 39
BP 16416
EP 16421
DI 10.1073/pnas.1111179108
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 825FB
UT WOS:000295255300058
PM 21930918
ER
PT J
AU Zhou, QG
McIntosh, DC
Lu, ZW
Campbell, JC
Sampath, AV
Shen, HE
Wraback, M
AF Zhou, Qiugui
McIntosh, Dion C.
Lu, Zhiwen
Campbell, Joe C.
Sampath, Anand V.
Shen, Hongen
Wraback, Michael
TI GaN/SiC avalanche photodiodes
SO APPLIED PHYSICS LETTERS
LA English
DT Article
DE avalanche photodiodes; dark conductivity; electric breakdown; gallium
compounds; III-V semiconductors; semiconductor epitaxial layers; silicon
AB Near ultraviolet-sensitive separate absorption and multiplication avalanche photodiodes with GaN/SiC epitaxial layers grown on SiC substrate were fabricated. Dark current < 1 pA at 90% breakdown voltage, maximum multiplication gain of similar to 10(5), and responsivity exceeding 4.2 A/W at 365 nm were achieved. (C) 2011 American Institute of Physics. [doi:10.1063/1.3636412]
C1 [Zhou, Qiugui; McIntosh, Dion C.; Lu, Zhiwen; Campbell, Joe C.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA.
[Sampath, Anand V.; Shen, Hongen; Wraback, Michael] AMSRD ARL SE EM, Army Res Lab, Adelphi, MD 20783 USA.
RP Campbell, JC (reprint author), Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA.
EM jcc7s@virginia.edu
RI Zhou, Qiugui/G-7357-2011
OI Zhou, Qiugui/0000-0002-7728-8765
NR 13
TC 10
Z9 10
U1 1
U2 13
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 26
PY 2011
VL 99
IS 13
AR 131110
DI 10.1063/1.3636412
PG 3
WC Physics, Applied
SC Physics
GA 829WZ
UT WOS:000295618000010
ER
PT J
AU Youssef, KM
Wang, YB
Liao, XZ
Mathaudhu, SN
Kecskes, LJ
Zhu, YT
Koch, CC
AF Youssef, K. M.
Wang, Y. B.
Liao, X. Z.
Mathaudhu, S. N.
Kecskes, L. J.
Zhu, Y. T.
Koch, C. C.
TI High hardness in a nanocrystalline Mg97Y2Zn1 alloy
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Nanocrystalline; Magnesium alloys, Mechanical alloying, Hardness
ID DEFORMATION-BEHAVIOR; MG ALLOY; MAGNESIUM; ULTRAFINE; STRENGTH; METALS
AB A nanocrystalline Mg97Y2Zn1 alloy was prepared with an average grain size of 21 nm by mechanical alloying of elemental powders. The structure of the alloy was characterized by X-ray diffraction and transmission electron microscopy. The hardness of the alloy as-milled for 8 h at room temperature was 2.1 GPa. After compaction and annealing at 573 K, the average grain size slightly increases to 28 nm with an increase in hardness to 2.4 GPa. These are the highest values for hardness yet reported for a crystalline Mg-based (>95% Mg) alloy. Possible factors leading to this high strength are discussed. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Youssef, K. M.; Zhu, Y. T.; Koch, C. C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA.
[Wang, Y. B.; Liao, X. Z.] Univ Sydney, Sch Aerosp Mech & Mechatron Engn, Sydney, NSW 2006, Australia.
[Mathaudhu, S. N.; Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Koch, CC (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA.
EM khaled_youssef@ncsu.edu
RI Mathaudhu, Suveen/B-4192-2009; Youssef, Khaled/F-4629-2010; Kecskes,
Laszlo/F-6880-2014; Liao, Xiaozhou/B-3168-2009; Zhu,
Yuntian/B-3021-2008; Wang, Yanbo/B-3175-2009
OI Youssef, Khaled/0000-0001-9850-5223; Kecskes,
Laszlo/0000-0002-1342-3729; Liao, Xiaozhou/0000-0001-8565-1758; Zhu,
Yuntian/0000-0002-5961-7422;
FU U.S. Army Research Laboratory [W911QX-08-C-0083]
FX The authors wish to acknowledge the U.S. Army Research Laboratory, under
contract number W911QX-08-C-0083 for support of the research.
NR 22
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Z9 8
U1 0
U2 11
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD SEP 25
PY 2011
VL 528
IS 25-26
BP 7494
EP 7499
DI 10.1016/j.msea.2011.06.017
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 824EB
UT WOS:000295184000004
ER
PT J
AU Al-Maharbi, M
Karaman, I
Beyerlein, IJ
Foley, D
Hartwig, KT
Kecskes, LJ
Mathaudhu, SN
AF Al-Maharbi, Majid
Karaman, Ibrahim
Beyerlein, Irene J.
Foley, David
Hartwig, K. Ted
Kecskes, Laszlo J.
Mathaudhu, Suveen N.
TI Microstructure, crystallographic texture, and plastic anisotropy
evolution in an Mg alloy during equal channel angular extrusion
processing
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Magnesium alloys; Equal channel angular pressing; Dynamic
recrystallization; Anisotropy; Tension-compression asymmetry
ID MAGNESIUM ALLOY; ROOM-TEMPERATURE; DEFORMATION MECHANISMS;
GRAIN-REFINEMENT; NONBASAL SLIP; AZ31 ALLOY; ZN ALLOY; BEHAVIOR; ECAE;
FLOW
AB In this article, we report on the relationship between the active deformation mechanisms and the development of texture, grain size and morphology, and dynamic recrystallization (DRX) during large plastic strain deformation of an AZ31B magnesium alloy. Equal channel angular extrusion (ECAE) is used to apply a variable amount and sequence of simple shearing at 200 degrees C. Two different starting textures were used: basal poles either aligned with or perpendicular to the extrusion direction. A multi-scale ECAE simulation model based on crystal plasticity was employed to determine the relative contributions of different slip systems during ECAE at 200 degrees C. These simulations clarified how different active deformation modes were responsible for specific grain size and distribution, and grain morphology as a function of the starting textures and ECAE route. For instance, we found that relatively intense prismatic slip activity suppresses DRX, which, in turn, leads to an elongated grain structure. Room temperature mechanical testing was carried out on the processed samples along three orthogonal directions to characterize flow stress anisotropy and tension-compression asymmetry. It is shown that with proper selection of the starting texture and ECAE route, it is possible to control the level of mechanical anisotropy in the processed samples and obtain strongly or weakly anisotropic mechanical response in Mg alloys. (C) 2011 Elsevier B.V All rights reserved.
C1 [Karaman, Ibrahim; Hartwig, K. Ted] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA.
[Al-Maharbi, Majid; Karaman, Ibrahim; Foley, David; Hartwig, K. Ted] Texas A&M Univ, Mat Sci & Engn Program, College Stn, TX 77843 USA.
[Beyerlein, Irene J.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA.
[Kecskes, Laszlo J.; Mathaudhu, Suveen N.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MB, Aberdeen, MD 21005 USA.
RP Karaman, I (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA.
EM ikaraman@tamu.edu
RI Beyerlein, Irene/A-4676-2011; Kecskes, Laszlo/F-6880-2014; Karaman,
Ibrahim/E-7450-2010; Foley, David/A-5414-2012; Mathaudhu,
Suveen/B-4192-2009
OI Kecskes, Laszlo/0000-0002-1342-3729; Karaman,
Ibrahim/0000-0001-6461-4958;
FU Army Research Laboratory [W911QX-08-P-0640]; National Science Foundation
- International Materials Institute [DMR 08-44082]; Office of Specific
Programs, Division of Materials Research, Arlington, Virginia; Los
Alamos National Laboratory Directed Research and Development (LDRD)
[DR20110029]
FX This work is funded by Army Research Laboratory contract no.
W911QX-08-P-0640. MAM and IK also acknowledge the support from the
National Science Foundation - International Materials Institute Program
through the grant no. DMR 08-44082, Office of Specific Programs,
Division of Materials Research, Arlington, Virginia. IJB gratefully
acknowledges support by a Los Alamos National Laboratory Directed
Research and Development (LDRD) grant, DR20110029.
NR 56
TC 41
Z9 42
U1 3
U2 31
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD SEP 25
PY 2011
VL 528
IS 25-26
BP 7616
EP 7627
DI 10.1016/j.msea.2011.06.043
PG 12
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 824EB
UT WOS:000295184000019
ER
PT J
AU Coller, BA
Barrett, ADT
Thomas, SJ
AF Coller, Beth-Ann
Barrett, Alan D. T.
Thomas, Stephen J.
TI Special Issue: The Development of Dengue Vaccines Introduction
SO VACCINE
LA English
DT Editorial Material
C1 [Coller, Beth-Ann] Merck & Co Inc, West Point, PA 19486 USA.
[Barrett, Alan D. T.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
RP Coller, BA (reprint author), Merck & Co Inc, 770 Sumneytown Pike, West Point, PA 19486 USA.
EM beth-ann.coller@merck.com; abarrett@utmb.edu;
stephen.thomas1@us.army.mil
NR 0
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD SEP 23
PY 2011
VL 29
IS 42
SI SI
BP 7219
EP 7220
DI 10.1016/j.vaccine.2011.06.057
PG 2
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 830NA
UT WOS:000295662500001
PM 21708208
ER
PT J
AU Milner, E
Gardner, S
Moon, J
Grauer, K
Auschwitz, J
Bathurst, I
Caridha, D
Gerena, L
Gettayacamin, M
Johnson, J
Kozar, M
Lee, P
Leed, S
Li, QG
McCalmont, W
Melendez, V
Roncal, N
Sciotti, R
Smith, B
Sousa, J
Tungtaeng, A
Wipf, P
Dow, G
AF Milner, Erin
Gardner, Sean
Moon, Jay
Grauer, Kristina
Auschwitz, Jennifer
Bathurst, Ian
Caridha, Diana
Gerena, Lucia
Gettayacamin, Montip
Johnson, Jacob
Kozar, Michael
Lee, Patricia
Leed, Susan
Li, Qigui
McCalmont, William
Melendez, Victor
Roncal, Norma
Sciotti, Richard
Smith, Bryan
Sousa, Jason
Tungtaeng, Anchalee
Wipf, Peter
Dow, Geoffrey
TI Structure-Activity Relationships of 4-Position Diamine Quinoline
Methanols as Intermittent Preventative Treatment (IPT) against
Plasmodium falciparum
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID SULFADOXINE-PYRIMETHAMINE; MEFLOQUINE; MALARIA
AB A library of diamine quinoline methanols were designed based on the mefloquine scaffold. The systematic variation of the 4-position amino alcohol side chain led to analogues that maintained potency while reducing accumulation in the central nervous system (CNS). Although the mechanism of action remains elusive, these data indicate that the 4-position side chain is critical for activity and that potency (as measured by IC(90)) does not correlate with accumulation in the CNS. A new lead compound, (S)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(2-(cyclopropylamino)ethylamino)ethanol (WR621308), was identified with single dose efficacy and substantially lower permeability across MDCK cell monolayers than mefloquine. This compound could be appropriate for intermittent preventative treatment (IPTx) indications or other malaria treatments currently approved for mefloquine.
C1 [Milner, Erin; Gardner, Sean; Moon, Jay; Grauer, Kristina; Auschwitz, Jennifer; Caridha, Diana; Gerena, Lucia; Johnson, Jacob; Kozar, Michael; Lee, Patricia; Leed, Susan; Li, Qigui; McCalmont, William; Melendez, Victor; Roncal, Norma; Sciotti, Richard; Smith, Bryan; Sousa, Jason; Dow, Geoffrey] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand.
[Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA.
[Bathurst, Ian] Int Ctr Cointrin, CH-1215 Geneva 15, Switzerland.
RP Milner, E (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
EM erin.milner@amedd.army.mil
RI Sousa, Jason/A-9177-2011; Sciotti, Richard/A-9069-2011
FU Medicines for Malaria Venture; Military Infectious Diseases Research
Program (MIDRP); United States Department of Defense; Absorption Systems
(Exton, PA)
FX This manuscript was reviewed by the Walter Reed Army Institute of
Research and the U.S. Army Medical Research and Materiel Command, and
there is no objection to its publication or dissemination. The opinions
expressed herein are those of the authors and do not necessarily reflect
the views or opinions of the Department of the Army and the Department
of Defense. All animal experiments were conducted in compliance with the
Animal Welfare Act and other federal statutes and regulations relating
to animals and experiments involving animals and adhere to the
principles stated in the Guide for the Care and Use of Laboratory
Animals (National Academy Press, 1996). The MDCK permeability assays
were performed under contract by Absorption Systems (Exton, PA). The
authors thank Steven Geib of the University of Pittsburgh for X-ray
analysis. We gratefully acknowledge substantial financial support from
Medicines for Malaria Venture, Military Infectious Diseases Research
Program (MIDRP), and the United States Department of Defense.
NR 14
TC 11
Z9 11
U1 2
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD SEP 22
PY 2011
VL 54
IS 18
BP 6277
EP 6285
DI 10.1021/jm200647u
PG 9
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 819ZN
UT WOS:000294875300010
PM 21854078
ER
PT J
AU Golden, JW
Zaitseva, M
Kapnick, S
Fisher, RW
Mikolajczyk, MG
Ballantyne, J
Golding, H
Hooper, JW
AF Golden, Joseph W.
Zaitseva, Marina
Kapnick, Senta
Fisher, Robert W.
Mikolajczyk, Malgorzata G.
Ballantyne, John
Golding, Hana
Hooper, Jay W.
TI Polyclonal antibody cocktails generated using DNA vaccine technology
protect in murine models of orthopoxvirus disease
SO VIROLOGY JOURNAL
LA English
DT Article
DE Smallpox; vaccinia immunoglobulin; monoclonal antibody; passive
protection; DNA vaccine; polyclonal antibody; bioluminescence
ID NEUTRALIZING MONOCLONAL-ANTIBODIES; INTRANASAL POXVIRUS CHALLENGE;
LETHAL RESPIRATORY CHALLENGE; OUTER-MEMBRANE PROTEINS; 2 INFECTIOUS
FORMS; SMALLPOX VACCINE; VIRUS CHALLENGE; PROGRESSIVE VACCINIA;
NONHUMAN-PRIMATES; IMMUNE GLOBULIN
AB Background: Previously we demonstrated that DNA vaccination of nonhuman primates (NHP) with a small subset of vaccinia virus (VACV) immunogens (L1, A27, A33, B5) protects against lethal monkeypox virus challenge. The L1 and A27 components of this vaccine target the mature virion (MV) whereas A33 and B5 target the enveloped virion (EV).
Results: Here, we demonstrated that the antibodies produced in vaccinated NHPs were sufficient to confer protection in a murine model of lethal Orthopoxvirus infection. We further explored the concept of using DNA vaccine technology to produce immunogen-specific polyclonal antibodies that could then be combined into cocktails as potential immunoprophylactic/therapeutics. Specifically, we used DNA vaccines delivered by muscle electroporation to produce polyclonal antibodies against the L1, A27, A33, and B5 in New Zealand white rabbits. The polyclonal antibodies neutralized both MV and EV in cell culture. The ability of antibody cocktails consisting of anti-MV, anti-EV, or a combination of anti-MV/EV to protect BALB/c mice was evaluated as was the efficacy of the anti-MV/EV mixture in a mouse model of progressive vaccinia. In addition to evaluating weight loss and lethality, bioimaging technology was used to characterize the spread of the VACV infections in mice. We found that the anti-EV cocktail, but not the anti-MV cocktail, limited virus spread and lethality.
Conclusions: A combination of anti-MV/EV antibodies was significantly more protective than anti-EV antibodies alone. These data suggest that DNA vaccine technology could be used to produce a polyclonal antibody cocktail as a possible product to replace vaccinia immune globulin.
C1 [Golden, Joseph W.; Hooper, Jay W.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Zaitseva, Marina; Kapnick, Senta; Golding, Hana] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
[Fisher, Robert W.; Mikolajczyk, Malgorzata G.] US FDA, Div Hematol, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
[Ballantyne, John] Aldevron LLC, Fargo, ND USA.
RP Hooper, JW (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM jay.hooper@amedd.army.mil
OI Hooper, Jay/0000-0002-4475-0415
FU National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Department of Health and Human Services [IAA
224-06-1322, IAA Y1-AI-9426-02]
FX We thank Matthew Josleyn, Andrew Wells and Leslie Jones for their
technical assistance in completing this work. We thank Michael
Merchlinsky and Jerry P. Weir for providing IHD-J-Luc vaccinia virus.
Opinions, interpretations, conclusions, and recommendations are those of
the author and are not necessarily endorsed by the U. S. Army or the
Department of Defense. Research was conducted in compliance with the
Animal Welfare Act and other federal statutes and regulations relating
to animals and experiments involving animals and adheres to principles
state in the Guide for the Care and Use of Laboratory Animals, National
Research Council, 1996. The facilities where this research was conducted
are fully accredited by the Association for Assessment and Accreditation
of Laboratory Animal Care International. This project has been funded in
part with Federal funds from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health, Department of Health
and Human Services under IAA 224-06-1322 and IAA Y1-AI-9426-02, Appendix
A120 B.19.
NR 82
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U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD SEP 20
PY 2011
VL 8
AR 441
DI 10.1186/1743-422X-8-441
PG 18
WC Virology
SC Virology
GA 832XG
UT WOS:000295843300001
PM 21933385
ER
PT J
AU Lilly, T
Ketsdever, A
Cornella, B
Quiller, T
Gimelshein, S
AF Lilly, Taylor
Ketsdever, Andrew
Cornella, Barry
Quiller, Trey
Gimelshein, Sergey
TI Gas density perturbations induced by a pulsed optical lattice
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID SCATTERING
AB A complimentary experimental and numerical investigation on density perturbations formed in molecular nitrogen by pulsed optical lattices was conducted. Experimental results on the effect of laser intensity and gas pressure on the magnitude of induced density perturbations from the free-molecular through continuum regimes using a coherent Rayleigh-Brillouin scattering technique are presented. The investigation further verifies the use of the direct simulation Monte Carlo method, extended to include the non-resonant optical dipole force, as a robust tool for the prediction of laser modification to a neutral gas. (C) 2011 American Institute of Physics. [doi:10.1063/1.3640216]
C1 [Lilly, Taylor; Ketsdever, Andrew] USA, Prop Directorate AFRL RZSA, Res Lab, Edwards AFB, CA 93524 USA.
[Cornella, Barry; Quiller, Trey; Gimelshein, Sergey] ERC Inc, Edwards AFB, CA 93524 USA.
RP Lilly, T (reprint author), USA, Prop Directorate AFRL RZSA, Res Lab, Edwards AFB, CA 93524 USA.
EM tlilly@uccs.edu
FU Air Force Office of Scientific Research (AFOSR); AFRL/RZSA; U.S. Army
Engineer Research and Development Center DoD Supercomputing Resource
Center (ERDC DSRC)
FX The authors would like to thank Dr. Mikhail Shneider at Princeton
University for his helpful discussions and input. This work was
supported by the Air Force Office of Scientific Research (AFOSR). The
authors would like to thank Dr. Mitat Birkan (AFOSR/RSA) for his support
of numerical efforts and Dr. Tatjana Curcic (AFOSR/RSE) for her support
of experimental efforts. This research was performed while T. C. Lilly
held a National Research Council Research Associateship Award at
AFRL/RZSA. This work was also supported, in part, by a grant of computer
time from the DOD High Performance Computing Modernization Program at
the U.S. Army Engineer Research and Development Center DoD
Supercomputing Resource Center (ERDC DSRC).
NR 14
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U1 0
U2 2
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 19
PY 2011
VL 99
IS 12
AR 124101
DI 10.1063/1.3640216
PG 3
WC Physics, Applied
SC Physics
GA 833AH
UT WOS:000295853500078
ER
PT J
AU Eller, MA
Slike, BM
Cox, JH
Lesho, E
Wang, ZN
Currier, JR
Darden, JM
Polonis, VR
Vahey, MT
Peel, S
Robb, ML
Michael, NL
Marovich, MA
AF Eller, Michael A.
Slike, Bonnie M.
Cox, Josephine H.
Lesho, Emil
Wang, Zhining
Currier, Jeffrey R.
Darden, Janice M.
Polonis, Victoria R.
Vahey, Maryanne T.
Peel, Sheila
Robb, Merlin L.
Michael, Nelson L.
Marovich, Mary A.
TI A Double-Blind Randomized Phase I Clinical Trial Targeting ALVAC-HIV
Vaccine to Human Dendritic Cells
SO PLOS ONE
LA English
DT Article
ID CD8(+) T-CELL; RESPONSES; MELANOMA; IMMUNE; GENERATION; MATURE;
MATURATION; INFECTION; PEPTIDES; EPITOPES
AB Background: We conducted a novel pilot study comparing different delivery routes of ALVAC-HIV (vCP205), a canarypox vaccine containing HIV gene inserts: env, gag and pol. We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone.
Methodology/Principal Findings: Healthy HIV-1 uninfected volunteers were administered ALVAC-HIV or placebo by intramuscular injection (IM), intradermal injection (ID) or subcutaneous injection (SQ) of autologous ex vivo transfected DC at months 0, 1, 3 and 6. All vaccine delivery routes were well tolerated. Binding antibodies were observed to both the ALVAC vector and HIV-1 gp160 proteins. Modest cellular responses were observed in 2/7 individuals in the DC arm and 1/8 in the IM arm as determined by IFN-gamma ELISPOT. Proliferative responses were most frequent in the DC arm where 4/7 individuals had measurable responses to multiple HIV-1 antigens. Loading DC after maturation resulted in lower gene expression, but overall better responses to both HIV-1 and control antigens, and were associated with better IL-2, TNF-alpha and IFN-gamma production.
Conclusions/Significance: ALVAC-HIV delivered IM, ID or SQ with autologous ex vivo transfected DC proved to be safe. The DC arm was most immunogenic. Proliferative immune responses were readily detected with only modest cytotoxic CD8 T cell responses. Loading mature DC with the live viral vaccine induced stronger immune responses than loading immature DC, despite increased transgene expression with the latter approach. Volunteers who received the autologous vaccine loaded mature DC developed a broader and durable immune response compared to those vaccinated by conventional routes.
C1 [Eller, Michael A.; Slike, Bonnie M.; Wang, Zhining; Currier, Jeffrey R.; Darden, Janice M.; Polonis, Victoria R.; Peel, Sheila; Robb, Merlin L.; Michael, Nelson L.; Marovich, Mary A.] US Mil HIV Res Program MHRP, Rockville, MD 20850 USA.
[Cox, Josephine H.] IAVI, New York, NY USA.
[Lesho, Emil; Vahey, Maryanne T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Eller, MA (reprint author), US Mil HIV Res Program MHRP, Rockville, MD 20850 USA.
EM mmarovich@hivresearch.org
FU U.S. Army Medical Research and Materiel Command
[W81XWH-07-2-6700-P00001]; Henry M. Jackson Foundation for the
Advancement of Military Medicine
FX This work was supported by the U.S. Army Medical Research and Materiel
Command and its Cooperative Agreement (W81XWH-07-2-6700-P00001) with the
Henry M. Jackson Foundation for the Advancement of Military Medicine.
The opinions expressed herein are those of the authors and do not
represent the official position of the U.S. Army or Department of
Defense. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 36
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U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2011
VL 6
IS 9
AR e24254
DI 10.1371/journal.pone.0024254
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 824BI
UT WOS:000295173800014
PM 21949699
ER
PT J
AU Riddle, MS
Kaminski, RW
Williams, C
Porter, C
Baqar, S
Kordis, A
Gilliland, T
Lapa, J
Coughlin, M
Soltis, C
Jones, E
Saunders, J
Keiser, PB
Ranallo, RT
Gormley, R
Nelson, M
Turbyfill, KR
Tribble, D
Oaks, EV
AF Riddle, Mark S.
Kaminski, Robert W.
Williams, Carlos
Porter, Chad
Baqar, Shahida
Kordis, Alexis
Gilliland, Theron
Lapa, Joyce
Coughlin, Melissa
Soltis, Chris
Jones, Erica
Saunders, Jackie
Keiser, Paul B.
Ranallo, Ryan T.
Gormley, Robert
Nelson, Michael
Turbyfill, K. Ross
Tribble, David
Oaks, Edwin V.
TI Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex
50 vaccine
SO VACCINE
LA English
DT Article
DE Shigella flexneri; Invaplex; Nasal vaccine; Immunogenicity
ID INVASIN COMPLEX; REACTIVE ARTHRITIS; MONOCLONAL-ANTIBODIES; INFLUENZA
VACCINE; EFFICACY; CELLS; MUCOSAL; VIRUS; INFECTION; LIVE
AB Background: Shigella flexneri 2a lipopolysaccharide 50 is a nasally delivered subunit vaccine consisting of a macromolecular complex composed of LPS, IpaB, IpaC and IpaD. The current study examined vaccine safety and immunogenicity across a dose range and the clinical performance of a new intranasal delivery device.
Methods: Volunteers (N = 36) were randomized to receive vaccine via the Dolphin (TM) (Valois of America, Congers, New York) intranasal spray device at one of three doses (240, 480, and 690 mu g) on days 0, 14, and 28. Another group (N = 8) received the 240 mu g dose via pipette. Vaccine safety was actively monitored and antigen-specific humoral and mucosal immune responses were determined.
Results: There were no serious adverse events and the majority of adverse events (98%) were mild. Antibody secreting cells (ASC), plasma, and mucosal immune responses to Shigella antigens were detected at all three dose levels with the 690 mu g dose inducing the highest magnitude and frequency of responses. Vaccination with comparable doses of Invaplex 50 via the Dolphin (TM) resulted in higher plasma and ASC immune responses as compared to pipette delivery.
Conclusion: In this trial the S. flexneri 2a Invaplex 50 vaccine was safe, well-tolerated and induced robust levels of antigen-specific intestinal IgA and ASC responses. The spray device performed well and offered an advantage over pipette intranasal delivery. Published by Elsevier Ltd.
C1 [Oaks, Edwin V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Subunit Enter Vaccines & Immunol, Silver Spring, MD 20910 USA.
[Riddle, Mark S.; Williams, Carlos; Porter, Chad; Baqar, Shahida; Gilliland, Theron; Lapa, Joyce; Gormley, Robert] Naval Med Res Ctr, Silver Spring, MD USA.
[Soltis, Chris; Keiser, Paul B.; Nelson, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Tribble, David] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Oaks, EV (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Subunit Enter Vaccines & Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM edwin.oaks@us.army.mil
RI Riddle, Mark/A-8029-2011
FU Military Infectious Disease Research Program
FX This study was conducted under support of Military Infectious Disease
Research Program.
NR 35
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U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD SEP 16
PY 2011
VL 29
IS 40
BP 7009
EP 7019
DI 10.1016/j.vaccine.2011.07.033
PG 11
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 825RT
UT WOS:000295300500024
PM 21787825
ER
PT J
AU Wu, SJ
Eiben, CB
Carra, JH
Huang, I
Zong, D
Liu, PX
Wu, CT
Nivala, J
Dunbar, J
Huber, T
Senft, J
Schokman, R
Smith, MD
Mills, JH
Friedlander, AM
Baker, D
Siegel, JB
AF Wu, Sean J.
Eiben, Christopher B.
Carra, John H.
Huang, Ivan
Zong, David
Liu, Peixian
Wu, Cindy T.
Nivala, Jeff
Dunbar, Josef
Huber, Tomas
Senft, Jeffrey
Schokman, Rowena
Smith, Matthew D.
Mills, Jeremy H.
Friedlander, Arthur M.
Baker, David
Siegel, Justin B.
TI Improvement of a Potential Anthrax Therapeutic by Computational Protein
Design
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID BACILLUS-ANTHRACIS; CAPSULE; TRANSPEPTIDASE; SEQUENCES; PLASMID; CAPD
AB Past anthrax attacks in the United States have highlighted the need for improved measures against bioweapons. The virulence of anthrax stems from the shielding properties of the Bacillus anthracis poly-gamma-D-glutamic acid capsule. In the presence of excess CapD, a B. anthracis gamma-glutamyl transpeptidase, the protective capsule is degraded, and the immune system can successfully combat infection. Although CapD shows promise as a next generation protein therapeutic against anthrax, improvements in production, stability, and therapeutic formulation are needed. In this study, we addressed several of these problems through computational protein engineering techniques. We show that circular permutation of CapD improved production properties and dramatically increased kinetic thermostability. At 45 degrees C, CapD was completely inactive after 5 min, but circularly permuted CapD remained almost entirely active after 30 min. In addition, we identify an amino acid substitution that dramatically decreased transpeptidation activity but not hydrolysis. Subsequently, we show that this mutant had a diminished capsule degradation activity, suggesting that CapD catalyzes capsule degradation through a transpeptidation reaction with endogenous amino acids and peptides in serum rather than hydrolysis.
C1 [Wu, Sean J.; Eiben, Christopher B.; Huang, Ivan; Zong, David; Liu, Peixian; Wu, Cindy T.; Nivala, Jeff; Dunbar, Josef; Huber, Tomas; Smith, Matthew D.; Mills, Jeremy H.; Baker, David; Siegel, Justin B.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA.
[Baker, David] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
[Carra, John H.; Senft, Jeffrey; Schokman, Rowena; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Siegel, JB (reprint author), Univ Washington, Dept Biochem, Seattle, WA 98195 USA.
EM siegeljb@uw.edu
RI Baker, David/K-8941-2012
OI Baker, David/0000-0001-7896-6217
FU Defense Advanced Research Projects Agency; Howard Hughes Medical
Institute
FX This work was supported by a grant from the Defense Advanced Research
Projects Agency and the Howard Hughes Medical Institute.
NR 21
TC 3
Z9 3
U1 1
U2 9
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD SEP 16
PY 2011
VL 286
IS 37
BP 32586
EP 32592
DI 10.1074/jbc.M111.251041
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 818CK
UT WOS:000294726800068
PM 21768086
ER
PT J
AU Gauer, RL
AF Gauer, Robert L.
TI Evaluation of Syncope
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID EMERGENCY-DEPARTMENT; EXTERNAL VALIDATION; RISK STRATIFICATION; SERIOUS
OUTCOMES; PREDICT PATIENTS; MANAGEMENT; RULE; ELECTROCARDIOGRAPHY;
CARDIOMYOPATHY; DEFIBRILLATOR
AB Syncope is a transient and abrupt loss of consciousness with complete return to preexisting neurologic function. It is classified as neurally mediated (i.e., carotid sinus hypersensitivity, situational, or vasovagal), cardiac, orthostatic, or neurogenic. Older adults are more likely to have orthostatic, carotid sinus hypersensitivity, or cardiac syncope, whereas younger adults are more likely to have vasovagal syncope. Common nonsyncopal syndromes with similar presentations include seizures, metabolic and psychogenic disorders, and acute intoxication. Patients presenting with syncope (other than neurally mediated and orthostatic syncope) are at increased risk of death from any cause. Useful clinical rules to assess the short-term risk of death and the need for immediate hospitalization include the San Francisco Syncope Rule and the Risk Stratification of Syncope in the Emergency Department rule. Guidelines suggest an algorithmic approach to the evaluation of syncope that begins with the history and physical examination. All patients presenting with syncope require electrocardiography, orthostatic vital signs, and QT interval monitoring. Patients with cardiovascular disease, abnormal electrocardiography, or family history of sudden death, and those presenting with unexplained syncope should be hospitalized for further diagnostic evaluation. Patients with neurally mediated or orthostatic syncope usually require no additional testing. In cases of unexplained syncope, further testing such as echocardiography, grade exercise testing, electrocardiographic monitoring, and electrophysiologic studies may be required. Although a subset of patients will have unexplained syncope despite undergoing a comprehensive evaluation, those with multiple episodes compared with an isolated event are more likely to have a serious underlying disorder. (Am Fam Physician. 2011;84(6):640-650. Copyright (C) 2011 American Academy of Family Physicians.)
C1 Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
RP Gauer, RL (reprint author), Womack Army Med Ctr, Bldg 4-2817,Riley Rd, Ft Bragg, NC 28310 USA.
EM robert.gauer@us.army.mil
NR 30
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U1 1
U2 3
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD SEP 15
PY 2011
VL 84
IS 6
BP 640
EP 650
PG 11
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 980AG
UT WOS:000306865400006
PM 21916389
ER
PT J
AU Krishnan, R
Riley, M
Lee, S
Lu, TM
AF Krishnan, Rahul
Riley, Michael
Lee, Sabrina
Lu, Toh-Ming
TI Vertically aligned biaxially textured molybdenum thin films
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID DEPOSITION; SUBSTRATE; ALIGNMENT; MECHANISM; DEPENDENCE; BICRYSTALS; MGO
AB Vertically aligned, biaxially textured molybdenum nanorods were deposited using dc magnetron sputtering with glancing flux incidence (alpha = 85 degrees with respect to the substrate normal) and a two-step substrate-rotation mode. These nanorods were identified with a body-centered cubic crystal structure. The formation of a vertically aligned biaxial texture with a [110] out-of-plane orientation was combined with a [-110] in-plane orientation. The kinetics of the growth process was found to be highly sensitive to an optimum rest time of 35 seconds for the two-step substrate rotation mode. At all other rest times, the nanorods possessed two separate biaxial textures each tilted toward one flux direction. While the in-plane texture for the vertical nanorods maintains maximum flux capture area, inclined Mo nanorods deposited at alpha = 85 degrees without substrate rotation display a [-1-1-4] in-plane texture that does not comply with the maximum flux capture area argument. Finally, an in situ capping film was deposited with normal flux incidence over the biaxially textured vertical nanorods resulting in a thin film over the porous nanorods. This capping film possessed the same biaxial texture as the nanorods and could serve as an effective substrate for the epitaxial growth of other functional materials. (C) 2011 American Institute of Physics. [doi:10.1063/1.3638452]
C1 [Lu, Toh-Ming] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
[Krishnan, Rahul] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
[Riley, Michael] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA.
[Lee, Sabrina] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA.
RP Lu, TM (reprint author), Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
EM lut@rpi.edu
FU NSF [NIRT 0506738]; NSF
FX This work was supported by NSF NIRT 0506738. Michael Riley has been
supported by an NSF IGERT Fellowship.
NR 24
TC 1
Z9 1
U1 0
U2 7
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD SEP 15
PY 2011
VL 110
IS 6
AR 064311
DI 10.1063/1.3638452
PG 5
WC Physics, Applied
SC Physics
GA 829XJ
UT WOS:000295619300132
ER
PT J
AU Zemba, S
Ames, M
Green, L
Botelho, MJ
Gossman, D
Linkov, I
Palma-Oliveira, J
AF Zemba, Stephen
Ames, Michael
Green, Laura
Botelho, Maria Joao
Gossman, David
Linkov, Igor
Palma-Oliveira, Jose
TI Emissions of metals and polychlorinated dibenzo(p)dioxins and furans
(PCDD/Fs) from Portland cement manufacturing plants: Inter-kiln
variability and dependence on fuel-types
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Cement kilns; Hazardous waste incineration; PCDD/F; Mercury; Heavy
metals
ID POLLUTANTS; WASTE
AB Emissions from Portland cement manufacturing facilities may increase health risks in nearby populations and are thus subject to stringent regulations. Direct testing of pollutant concentrations in exhaust gases provides the best basis for assessing the extent of these risks. However, these tests (i) are often conducted under stressed, rather than typical, operating conditions, (ii) may be limited in number and duration, and (iii) may be influenced by specific fuel-types and attributes of individual kilns. We report here on the results of more than 150 emissions-tests conducted of two kilns at a Portland cement manufacturing plant in Portugal. The tests measured various regulated metals and polychlorinated dibenzo(p)dioxins and furans (PCDD/Fs). Stack-gas concentrations of pollutants were found to be highly variable, with standard deviations on the order of mean values. Emission rates of many pollutants were higher when coal was used as the main kiln fuel (instead of petroleum coke). Use of various supplemental fuels, however, had little effect on stack emissions, and few statistically significant differences were observed when hazardous waste was included in the fuel mix. Significant differences in emissions for some pollutants were observed between the two kilns despite their similar designs and uses of similar fuels. All measured values were found to be within applicable regulatory limits. Published by Elsevier B.V.
C1 [Zemba, Stephen; Ames, Michael; Green, Laura] Cambridge Environm Inc, Cambridge, MA 02141 USA.
[Botelho, Maria Joao] Secil Companhia Geral Cal & Cimento, Lisbon, Portugal.
[Gossman, David] Gossman Consulting Inc, Maquoketa, IA 52060 USA.
[Linkov, Igor] Carnegie Mellon Univ, Cambridge, MA 02446 USA.
[Linkov, Igor] US Army Engn Res & Dev Ctr, Cambridge, MA 02446 USA.
[Palma-Oliveira, Jose] FP Univ Lisbon, P-1649013 Lisbon, Portugal.
RP Zemba, S (reprint author), Cambridge Environm Inc, 58 Charles St, Cambridge, MA 02141 USA.
EM Zemba@CambridgeEnvironmental.com; Ames@CambridgeEnvironmental.com;
Green@CambridgeEnvironmental.com; maria.joao.botelho@secil.pt;
dgossman@gcisolutions.com; ilinkov@yahoo.com; Jpalma-oliveira@fp.ul.pt
OI Palma-Oliveira, Jose/0000-0001-9799-3464
FU Secil Companhia Geral de Cal e Cimento
FX This work was sponsored in part by Secil Companhia Geral de Cal e
Cimento S.A. Stack test sampling and analysis was performed by the firms
Sondar and Eurofins/Ergo.
NR 20
TC 18
Z9 19
U1 2
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD SEP 15
PY 2011
VL 409
IS 20
BP 4198
EP 4205
DI 10.1016/j.scitotenv.2011.06.047
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 825UB
UT WOS:000295306500005
PM 21835438
ER
PT J
AU Oliver, KE
Farley, JH
AF Oliver, Kate E.
Farley, John H.
TI Deciphering Surveillance, Epidemiology, and End Results Data Analysis
Are We Seeing the Whole Picture?
SO CANCER
LA English
DT Editorial Material
ID CANCER-DATA-BASE; ENDOMETRIAL CANCER; CARCINOMA
C1 [Farley, John H.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA.
[Oliver, Kate E.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA.
RP Farley, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM john.farley@us.army.mil
RI Oliver, Kate/H-7599-2014
OI Oliver, Kate/0000-0002-0595-9080
NR 15
TC 5
Z9 5
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
J9 CANCER-AM CANCER SOC
JI Cancer
PD SEP 15
PY 2011
VL 117
IS 18
BP 4112
EP 4115
DI 10.1002/cncr.26027
PG 4
WC Oncology
SC Oncology
GA 824EU
UT WOS:000295186000006
PM 21387280
ER
PT J
AU He, QG
Yang, XF
Ren, XM
Koel, BE
Ramaswamy, N
Mukerjee, S
Kostecki, R
AF He, Qinggang
Yang, Xiaofang
Ren, Xiaoming
Koel, Bruce E.
Ramaswamy, Nagappan
Mukerjee, Sanjeev
Kostecki, Robert
TI A novel CuFe-based catalyst for the oxygen reduction reaction in
alkaline media
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Alkaline fuel cell; Oxygen reduction reaction; Non-noble
electrocatalyst; CuFe
ID ANION-EXCHANGE MEMBRANE; PEM FUEL-CELLS; IRON PHTHALOCYANINES; O-2
REDUCTION; CARBON; ELECTROCATALYSTS; COBALT; NANOPARTICLES; TEMPERATURE;
ELECTRODES
AB The primary objective of this work is to develop alternative electrocatalysts to Pt-based materials for the oxygen reduction reaction (ORR) in alkaline fuel cells. We synthesized a bicore CuFe/C composite electrocatalyst by impregnation of iron and copper phthalocyanine-based complexes into a carbon support, followed by pyrolysis at 800-900 degrees C in an Ar atmosphere. This novel composite catalyst exhibits electrochemical performance for ORR in 0.1 M KOH similar to a commercial Pt/C (BASF Fuel Cell. 30%) catalyst at 6-fold lower CuFe loading. High resolution X-ray photoelectron spectroscopy (HR-XPS) results indicate that coordination bonding between Fe and N atoms still remains and show that a mixed Cu(I)/Cu(II) valency exists in the CuFe/C catalyst after high temperature heat treatment. The Cu(I)/Cu(II) redox mediator adjacent to Fe atoms is crucial to provide electrons to the NxFe-O-2 adduct and maximize the overall rate of the reduction reaction. The results of this study may offer a new approach to development of efficient catalysts for oxygen reduction to water in alkaline media. (C) 2011 Elsevier B.V. All rights reserved.
C1 [He, Qinggang; Kostecki, Robert] Lawrence Berkeley Natl Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA.
[Yang, Xiaofang; Koel, Bruce E.] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA.
[Yang, Xiaofang; Koel, Bruce E.] Lehigh Univ, Ctr Adv Mat & Nanotechnol, Bethlehem, PA 18015 USA.
[Ren, Xiaoming] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
[Ramaswamy, Nagappan; Mukerjee, Sanjeev] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
RP Kostecki, R (reprint author), Lawrence Berkeley Natl Lab, Environm Energy Technol Div, 1 Cyclotron Rd, Berkeley, CA 94720 USA.
EM R_Kostecki@lbl.gov
RI ren, xiaoming/F-3953-2011; dong, guofa/D-5248-2011; Yang,
Xiaofang/K-4388-2012; Koel, Bruce/H-3857-2013; He, Qinggang/O-7639-2014
OI Koel, Bruce/0000-0002-0032-4991; He, Qinggang/0000-0002-7693-8017
FU Office of Hydrogen, Fuel Cells and Infrastructure Technologies of the
U.S. Department of Energy [DE-AC02-05CH11231]; National Science
Foundation [0616644]
FX This work was supported by the Assistant Secretary for Energy Efficiency
and Renewable Energy, Office of Hydrogen, Fuel Cells and Infrastructure
Technologies of the U.S. Department of Energy under Contract No.
DE-AC02-05CH11231. Part of this work was supported by the National
Science Foundation under Grant No. 0616644. The authors would like to
thank Dr. Agustin Bueno Lopez for assistance with the TEM experiments.
NR 62
TC 33
Z9 33
U1 9
U2 83
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD SEP 15
PY 2011
VL 196
IS 18
SI SI
BP 7404
EP 7410
DI 10.1016/j.jpowsour.2011.04.016
PG 7
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 807YS
UT WOS:000293939500005
ER
PT J
AU Ratchford, JB
Schuster, BE
Crawford, BA
Lundgren, CA
Allen, JL
Wolfenstine, J
AF Ratchford, J. B.
Schuster, B. E.
Crawford, B. A.
Lundgren, C. A.
Allen, J. L.
Wolfenstine, J.
TI Young's modulus of polycrystalline Li22Si5
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Lithium; Silicon; Li22Si5; Young's modulus; Nanoindentation
ID ELASTIC-MODULUS; MECHANICAL-PROPERTIES; GRAIN-SIZE; INDENTATION
TECHNIQUES; ROOM-TEMPERATURE; LITHIUM; POROSITY; HARDNESS; SILICON;
ALLOY
AB In order for Li-Si alloys to be used in Li-ion batteries as anodes, knowledge of their mechanical properties, such as Young's moduli, is crucial. Young's modulus of polycrystalline Li22Si5 was determined from nanoindentation testing. The value of Young's modulus was 35.4 +/- 4.3 GPa. This value is approximately one-half of the predicted value based on density functional theory calculations. This difference was not a result of the testing procedure or microstructural variables. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Ratchford, J. B.; Lundgren, C. A.; Allen, J. L.; Wolfenstine, J.] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA.
[Schuster, B. E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Crawford, B. A.] Nanomechanics Inc, Analyt Serv Lab, Oak Ridge, TN 37830 USA.
RP Ratchford, JB (reprint author), USA, Res Lab, Adelphi Lab Ctr, 2800 Powder Mill Road, Adelphi, MD 20783 USA.
EM joshua.ratchford@us.army.mil
FU Army Research Laboratory; National Research Council at the United States
Army Research Laboratory
FX The authors are grateful to Andre Roy, Bob Ralph and Bruce Poese for
their technical assistance and to the Army Research Laboratory for
financial support. This research was performed while JBR held a National
Research Council Research Associateship Award at the United States Army
Research Laboratory.
NR 33
TC 16
Z9 17
U1 5
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD SEP 15
PY 2011
VL 196
IS 18
SI SI
BP 7747
EP 7749
DI 10.1016/j.jpowsour.2011.04.042
PG 3
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 807YS
UT WOS:000293939500052
ER
PT J
AU Carette, JE
Raaben, M
Wong, AC
Herbert, AS
Obernosterer, G
Mulherkar, N
Kuehne, AI
Kranzusch, PJ
Griffin, AM
Ruthel, G
Dal Cin, P
Dye, JM
Whelan, SP
Chandran, K
Brummelkamp, TR
AF Carette, Jan E.
Raaben, Matthijs
Wong, Anthony C.
Herbert, Andrew S.
Obernosterer, Gregor
Mulherkar, Nirupama
Kuehne, Ana I.
Kranzusch, Philip J.
Griffin, April M.
Ruthel, Gordon
Dal Cin, Paola
Dye, John M.
Whelan, Sean P.
Chandran, Kartik
Brummelkamp, Thijn R.
TI Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
SO NATURE
LA English
DT Article
ID VESICULAR STOMATITIS-VIRUS; LAKE-VICTORIA-MARBURGVIRUS;
HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; HUMAN-CELLS; GLYCOPROTEIN; DISEASE;
IDENTIFICATION; GENE; TRAFFICKING
AB Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in humans for which no approved antivirals are available(1). Filovirus entry is mediated by the viral spike glycoprotein (GP), which attaches viral particles to the cell surface, delivers them to endosomes and catalyses fusion between viral and endosomal membranes(2). Additional host factors in the endosomal compartment are probably required for viral membrane fusion; however, despite considerable efforts, these critical host factors have defied molecular identification(3-5). Here we describe a genome-wide haploid genetic screen in human cells to identify host factors required for Ebola virus entry. Our screen uncovered 67 mutations disrupting all six members of the homotypic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, which is involved in the fusion of endosomes to lysosomes(6), and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann-Pick C1 (NPC1)(7). Cells defective for the HOPS complex or NPC1 function, including primary fibroblasts derived from human Niemann-Pick type C1 disease patients, are resistant to infection by Ebola virus and Marburg virus, but remain fully susceptible to a suite of unrelated viruses. We show that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport. Our findings uncover unique features of the entry pathway used by filoviruses and indicate potential antiviral strategies to combat these deadly agents.
C1 [Carette, Jan E.; Obernosterer, Gregor; Brummelkamp, Thijn R.] Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA.
[Raaben, Matthijs; Kranzusch, Philip J.; Griffin, April M.; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA.
[Wong, Anthony C.; Mulherkar, Nirupama; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
[Herbert, Andrew S.; Kuehne, Ana I.; Ruthel, Gordon; Dye, John M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Dal Cin, Paola] Ctr Adv Mol Diagnost, Boston, MA 02115 USA.
RP Brummelkamp, TR (reprint author), Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
EM John.M.Dye1@us.army.mil; sean_whelan@hms.harvard.edu;
kartik.chandran@einstein.yu.edu; t.brummelkamp@nki.nl
FU NIH [R01 AI088027, AI081842, U54 AI057159, R21 HG004938]; DTRA Project
[CBM.VAXPLAT.05.10.RD.005]; Whitehead Fellows Program; Burroughs
Wellcome Investigators in the Pathogenesis of Infectious Disease Award;
NIH at the Albert Einstein College of Medicine [T32 GM007288, T32
AI070117]
FX We would like to thank M. Kielian, H. Ploegh, V. Prasad and D. Sabatini
for critical reading of the manuscript and valuable advice; C.
Guimaraes, V. Blomen and T. Peterson for suggestions; M. Bogyo for
providing the CTSB/CATL activity probe (GB111); T.-Y. Chang for the gift
of NPC1-null CHO cells; D. Lyles for the antibody to VSV M; M. Nibert
for providing reovirus; J. de la Torre for providing rVSV-GP-BDV; J.
Wojcechowskyj for providing RVF; E. Muhlberger for providing Ebola cDNA;
and M. Ericsson for support with electron microscopy. This research was
supported by NIH grants R01 AI088027 (K. C.), AI081842 and U54 AI057159
(NERCE-BEID) (S. P. W.), and R21 HG004938 (T. R. B.), and by the DTRA
Project, CBM.VAXPLAT.05.10.RD.005 (J. M. D.). T. R. B. was additionally
supported by the Whitehead Fellows Program. S. P. W. is a recipient of a
Burroughs Wellcome Investigators in the Pathogenesis of Infectious
Disease Award. A. C. W. was additionally supported by NIH-funded
training programs T32 GM007288 and T32 AI070117 at the Albert Einstein
College of Medicine. Opinions, interpretations, conclusions and
recommendations are those of the authors and are not necessarily
endorsed by the US Army.
NR 49
TC 342
Z9 354
U1 19
U2 128
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 15
PY 2011
VL 477
IS 7364
BP 340
EP U115
DI 10.1038/nature10348
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 819TD
UT WOS:000294852400033
PM 21866103
ER
PT J
AU Cote, M
Misasi, J
Ren, T
Bruchez, A
Lee, K
Filone, CM
Hensley, L
Li, Q
Ory, D
Chandran, K
Cunningham, J
AF Cote, Marceline
Misasi, John
Ren, Tao
Bruchez, Anna
Lee, Kyungae
Filone, Claire Marie
Hensley, Lisa
Li, Qi
Ory, Daniel
Chandran, Kartik
Cunningham, James
TI Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola
virus infection
SO NATURE
LA English
DT Article
ID STEROL-SENSING DOMAIN; CHOLESTEROL ACCUMULATION; ZAIRE EBOLAVIRUS; VIRAL
ENTRY; BINDING; GLYCOPROTEIN; PROTEIN; TRAFFICKING; EVENTS;
IDENTIFICATION
AB Ebola virus (EboV) is a highly pathogenic enveloped virus that causes outbreaks of zoonotic infection in Africa. The clinical symptoms are manifestations of the massive production of pro-inflammatory cytokines in response to infection(1) and in many outbreaks, mortality exceeds 75%. The unpredictable onset, ease of transmission, rapid progression of disease, high mortality and lack of effective vaccine or therapy have created a high level of public concern about EboV(2). Here we report the identification of a novel benzylpiperazine adamantane diamide-derived compound that inhibits EboV infection. Using mutant cell lines and informative derivatives of the lead compound, we show that the target of the inhibitor is the endosomal membrane protein Niemann-Pick C1 (NPC1). We find that NPC1 is essential for infection, that it binds to the virus glycoprotein (GP), and that antiviral compounds interfere with GP binding to NPC1. Combined with the results of previous studies of GP structure and function, our findings support a model of EboV infection in which cleavage of the GP1 subunit by endosomal cathepsin proteases removes heavily glycosylated domains to expose the amino-terminal domain(3-7), which is a ligand for NPC1 and regulates membrane fusion by the GP2 subunit(8). Thus, NPC1 is essential for EboV entry and a target for antiviral therapy.
C1 [Cote, Marceline; Misasi, John; Bruchez, Anna; Filone, Claire Marie; Li, Qi; Chandran, Kartik; Cunningham, James] Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA.
[Misasi, John] Childrens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA.
[Ren, Tao; Lee, Kyungae] Harvard Univ, Sch Med, New England Reg Ctr Excellence Biodefense & Emerg, Boston, MA 02115 USA.
[Filone, Claire Marie; Hensley, Lisa] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
[Ory, Daniel] Washington Univ, Sch Med, Diabet Cardiovasc Dis Ctr, St Louis, MO 63110 USA.
[Cunningham, James] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA 02115 USA.
RP Cunningham, J (reprint author), Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA.
EM jcunningham@rics.bwh.harvard.edu
FU PIDS-Sanofi-Pasteur Fellowship [K12-HD052896, 5K08AI079381,
5-T32-HL007623]; Fonds de la Recherche en Sante du Quebec; US Army
Medical Research and Material Command; [U54 AI057159]; [R01 CA104266]
FX We thank B. Considine, A. Nilsson and S. Wilkes for assistance, S.
Chiang for critical reading of the manuscript, G. Beltz, N. Gray, S.
Grinstein, Y. Iannou, R. Infante, J. Kornhuber, F. Sharom and S. Whelan
for discussion. This work was supported by grants from U54 AI057159, R01
CA104266 to J. C., PIDS-Sanofi-Pasteur Fellowship, K12-HD052896 and
5K08AI079381 to J. M., 5-T32-HL007623 to A.B., and fellowship from Fonds
de la Recherche en Sante du Quebec to M. C.; C. M. F. was supported by
the Postgraduate Research Participation Program at the US Army Medical
Research and Material Command administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
US Department of Energy and USAMRMC.
NR 30
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U1 8
U2 101
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 15
PY 2011
VL 477
IS 7364
BP 344
EP U122
DI 10.1038/nature10380
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 819TD
UT WOS:000294852400034
PM 21866101
ER
PT J
AU Thera, MA
Doumbo, OK
Coulibaly, D
Laurens, MB
Ouattara, A
Kone, AK
Guindo, AB
Traore, K
Traore, I
Kouriba, B
Diallo, DA
Diarra, I
Daou, M
Dolo, A
Tolo, Y
Sissoko, MS
Niangaly, A
Sissoko, M
Takala-Harrison, S
Lyke, KE
Wu, YK
Blackwelder, WC
Godeaux, O
Vekemans, J
Dubois, MC
Ballou, WR
Cohen, J
Thompson, D
Dube, T
Soisson, L
Diggs, CL
House, B
Lanar, DE
Dutta, S
Heppner, DG
Plowe, CV
AF Thera, Mahamadou A.
Doumbo, Ogobara K.
Coulibaly, Drissa
Laurens, Matthew B.
Ouattara, Amed
Kone, Abdoulaye K.
Guindo, Ando B.
Traore, Karim
Traore, Idrissa
Kouriba, Bourema
Diallo, Dapa A.
Diarra, Issa
Daou, Modibo
Dolo, Amagana
Tolo, Youssouf
Sissoko, Mahamadou S.
Niangaly, Amadou
Sissoko, Mady
Takala-Harrison, Shannon
Lyke, Kirsten E.
Wu, Yukun
Blackwelder, William C.
Godeaux, Olivier
Vekemans, Johan
Dubois, Marie-Claude
Ballou, W. Ripley
Cohen, Joe
Thompson, Darby
Dube, Tina
Soisson, Lorraine
Diggs, Carter L.
House, Brent
Lanar, David E.
Dutta, Sheetij
Heppner, D. Gray, Jr.
Plowe, Christopher V.
TI A Field Trial to Assess a Blood-Stage Malaria Vaccine
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID PLASMODIUM-FALCIPARUM MALARIA; RANDOMIZED CONTROLLED-TRIAL;
CIRCUMSPOROZOITE PROTEIN VACCINE; INSTITUTE-OF-RESEARCH; EFFICACY;
IMMUNOGENICITY; CHILDREN; SAFETY; ADULTS; CANDIDATE
AB Background
Blood-stage malaria vaccines are intended to prevent clinical disease. The malaria vaccine FMP2.1/AS02(A), a recombinant protein based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, has previously been shown to have immunogenicity and acceptable safety in Malian adults and children.
Methods
In a double-blind, randomized trial, we immunized 400 Malian children with either the malaria vaccine or a control (rabies) vaccine and followed them for 6 months. The primary end point was clinical malaria, defined as fever and at least 2500 parasites per cubic millimeter of blood. A secondary end point was clinical malaria caused by parasites with the AMA1 DNA sequence found in the vaccine strain.
Results
The cumulative incidence of the primary end point was 48.4% in the malaria-vaccine group and 54.4% in the control group; efficacy against the primary end point was 17.4% (hazard ratio for the primary end point, 0.83; 95% confidence interval [CI], 0.63 to 1.09; P=0.18). Efficacy against the first and subsequent episodes of clinical malaria, as defined on the basis of various parasite-density thresholds, was approximately 20%. Efficacy against clinical malaria caused by parasites with AMA1 corresponding to that of the vaccine strain was 64.3% (hazard ratio, 0.36; 95% CI, 0.08 to 0.86; P=0.03). Local reactions and fever after vaccination were more frequent with the malaria vaccine.
Conclusions
On the basis of the primary end point, the malaria vaccine did not provide significant protection against clinical malaria, but on the basis of secondary results, it may have strain-specific efficacy. If this finding is confirmed, AMA1 might be useful in a multicomponent malaria vaccine. (Funded by the National Institute of Allergy and Infectious Diseases and others; ClinicalTrials.gov number, NCT00460525.)
C1 [Laurens, Matthew B.; Ouattara, Amed; Takala-Harrison, Shannon; Lyke, Kirsten E.; Wu, Yukun; Blackwelder, William C.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Ouattara, Amed; Kone, Abdoulaye K.; Guindo, Ando B.; Traore, Karim; Traore, Idrissa; Kouriba, Bourema; Diallo, Dapa A.; Diarra, Issa; Daou, Modibo; Dolo, Amagana; Tolo, Youssouf; Sissoko, Mahamadou S.; Niangaly, Amadou; Sissoko, Mady] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali.
[Godeaux, Olivier; Vekemans, Johan; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium.
[Thompson, Darby; Dube, Tina] EMMES, Rockville, MD USA.
[Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA.
[House, Brent; Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Plowe, CV (reprint author), Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, 685 W Baltimore St,HSF1-480, Baltimore, MD 21201 USA.
EM cplowe@medicine.umaryland.edu
RI Wu, Yukun/G-4292-2012; Laurens, Matthew/E-7293-2013
OI Laurens, Matthew/0000-0003-3874-581X
FU National Institute of Allergy and Infectious Diseases [NCT00460525,
N01AI85346, U19AI065683, HH-SN272200800013C]; Fogarty International
Center, National Institutes of Health [D43TW001589]; Department of
Defense [W81XWH-06-1-0427]; U.S. Agency for International Development
for site development; U.S. Agency for International Development;
Military Infectious Diseases Research Program; Doris Duke Charitable
Foundation; Howard Hughes Medical Institute
FX Funded by the National Institute of Allergy and Infectious Diseases and
others; ClinicalTrials.gov number, NCT00460525.; Supported by a contract
(N01AI85346) and a cooperative agreement (U19AI065683) from the National
Institute of Allergy and Infectious Diseases, a grant (D43TW001589) from
the Fogarty International Center, National Institutes of Health, and a
contract (W81XWH-06-1-0427) from the Department of Defense and the U.S.
Agency for International Development for site development and the
conduct of the trial; by a contract (HH-SN272200800013C) from the
National Institute of Allergy and Infectious Diseases for data
management and statistical support; by grants from the U.S. Agency for
International Development and the Military Infectious Diseases Research
Program, Fort Detrick, MD, for vaccine production and laboratory assays;
and by the Doris Duke Charitable Foundation Distinguished Clinical
Scientist Award and an award from the Howard Hughes Medical Institute
(to Dr. Plowe).; We thank Steven Rosenthal, Walter Jones, Abdollah
Naficy, and Lee Hall of the National Institute of Allergy and Infectious
Diseases for support and advice; Mariam Traore Guindo and Boubacar
Kouyate for serving as local medical monitors; the study monitors,
Norbert Tamm (of PPD) and Denise McKinney (of the U. S. Army Medical
Materiel and Development Activity); Valerie Brown and the malaria team
at EMMES; Mirjana Nesin, medical monitor, National Institute of Allergy
and Infectious Diseases, and members of the data and safety monitoring
board (Anna Durbin, Kathryn Edwards, Cristina Sison, Elissa Malkin,
Mariam Traore Guindo, and David Diemert); Amanda Leach and the
GlaxoSmithKline Malaria Vaccine Project Team (in particular, Marie-Ange
Demoitie, Yannick Vanloubbeeck, and Marc Lievens); Mahamadou Traore,
Bourama Kane, Mamadou Dembele, and the Bandiagara District Hospital
staff for clinical assistance; Danzele Coulibaly, Sekouba Mariko, and
Moctar Traore for administrative support; Nicole Eddington, Carey
Martin, and Lisa Ware for technical and administrative support; Karen
Ball for regulatory support; the team of the Bandiagara Malaria Project
in Bandiagara for their dedication; and the community of Bandiagara,
Mali.
NR 24
TC 146
Z9 147
U1 2
U2 12
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD SEP 15
PY 2011
VL 365
IS 11
BP 1004
EP 1013
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 819UR
UT WOS:000294857300008
PM 21916638
ER
PT J
AU Srikiatkhachorn, A
Rothman, AL
Gibbons, RV
Sittisombut, N
Malasit, P
Ennis, FA
Nimmannitya, S
Kalayanarooj, S
AF Srikiatkhachorn, Anon
Rothman, Alan L.
Gibbons, Robert V.
Sittisombut, Nopporn
Malasit, Prida
Ennis, Francis A.
Nimmannitya, Suchitra
Kalayanarooj, Siripen
TI Dengue-How Best to Classify It
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Editorial Material
ID HEMORRHAGIC-FEVER; CASE CLASSIFICATION; CASE DEFINITIONS; UNITED-STATES;
INFECTION; SEVERITY; HEALTH; CHILDREN; NICARAGUA; THAILAND
AB Dengue has emerged as a major public health problem worldwide. Dengue virus infection causes a wide range of clinical manifestations. Since the 1970s, clinical dengue has been classified according to the World Health Organization guideline as dengue fever and dengue hemorrhagic fever. The classification has been criticized with regard to its usefulness and its applicability. In 2009, the World Health Organization issued a new guideline that classifies clinical dengue as dengue and severe dengue. The 2009 classification differs significantly from the previous classification in both conceptual and practical levels. The impacts of the new classification on clinical practice, dengue research, and public health policy are discussed.
C1 [Srikiatkhachorn, Anon; Ennis, Francis A.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA.
[Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA.
[Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Sittisombut, Nopporn] Chiang Mai Univ, Dept Microbiol, Fac Med, Chiang Mai 50000, Thailand.
[Malasit, Prida] Mahidol Univ, Med Mol Biol Unit, Siriraj Hop, Bangkok 10700, Thailand.
[Nimmannitya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Srikiatkhachorn, A (reprint author), Univ Massachusetts, Sch Med, Dept Med, 55 Lake Ave N,Rm S6-862, Worcester, MA 01655 USA.
EM anon.srikiatkhachorn@umassmed.edu
FU NIAID NIH HHS [NIH-P01AI34533, P01 AI034533]
NR 35
TC 38
Z9 38
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2011
VL 53
IS 6
BP 563
EP 567
DI 10.1093/cid/cir451
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 813JQ
UT WOS:000294363100016
PM 21832264
ER
PT J
AU Hahs, DW
Pethel, SD
AF Hahs, Daniel W.
Pethel, Shawn D.
TI Distinguishing Anticipation from Causality: Anticipatory Bias in the
Estimation of Information Flow
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID TRANSFER ENTROPY; TIME-SERIES; SYNCHRONIZATION; OSCILLATORS; DIRECTION;
NEURONS
AB We report that transfer entropy estimates obtained from low-resolution and/or small data sets show net information flow away from a purely anticipatory element whereas transfer entropy calculated using exact distributions show the flow towards it. This means that for real-world data sets anticipatory elements can appear to be strongly driving the network dynamics even when there is no possibility of such an influence. Furthermore, we show that in the low-resolution limit there is no statistic that can distinguish anticipatory elements from causal ones.
C1 [Hahs, Daniel W.; Pethel, Shawn D.] USA, RDECOM, RDMR WSS, Redstone Arsenal, AL 35898 USA.
RP Hahs, DW (reprint author), USA, RDECOM, RDMR WSS, Redstone Arsenal, AL 35898 USA.
NR 38
TC 19
Z9 19
U1 0
U2 11
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD SEP 14
PY 2011
VL 107
IS 12
AR 128701
DI 10.1103/PhysRevLett.107.128701
PG 5
WC Physics, Multidisciplinary
SC Physics
GA 820TU
UT WOS:000294929400012
PM 22026807
ER
PT J
AU Eckart, RE
Shry, EA
Burke, AP
McNear, JA
Appel, DA
Castillo-Rojas, LM
Avedissian, L
Pearse, LA
Potter, RN
Tremaine, L
Gentlesk, PJ
Huffer, L
Reich, SS
Stevenson, WG
AF Eckart, Robert E.
Shry, Eric A.
Burke, Allen P.
McNear, Jennifer A.
Appel, David A.
Castillo-Rojas, Laudino M.
Avedissian, Lena
Pearse, Lisa A.
Potter, Robert N.
Tremaine, Ladd
Gentlesk, Philip J.
Huffer, Linda
Reich, Stephen S.
Stevenson, William G.
CA Dept Def Cardiovasc Death Registry
TI Sudden Death in Young Adults An Autopsy-Based Series of a Population
Undergoing Active Surveillance
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE hypertrophic cardiomyopathy; resuscitation; sudden death; unexplained
death; young adult
ID POSTMORTEM MOLECULAR ANALYSIS; UNEXPLAINED DEATH; CARDIAC DEATH;
HEART-DISEASE; RISK; IDENTIFICATION; AUSTRALIANS; MILITARY; RECRUITS;
MRFIT
AB Objectives The purpose of this study was to define the incidence and characterization of cardiovascular cause of sudden death in the young.
Background The epidemiology of sudden cardiac death (SCD) in young adults is based on small studies and uncontrolled observations. Identifying causes of sudden death in this population is important for guiding approaches to prevention.
Methods We performed a retrospective cohort study using demographic and autopsy data from the Department of Defense Cardiovascular Death Registry over a 10-year period comprising 15.2 million person-years of active surveillance.
Results We reviewed all nontraumatic sudden deaths in persons 18 years of age and over. We identified 902 subjects in whom the adjudicated cause of death was of potential cardiac etiology, with a mean age of 38 +/- 11 years. The mortality rate for SCD per 100,000 person-years for the study period was 6.7 for males and 1.4 for females (p < 0.0001). Sudden death was attributed to a cardiac condition in 715 (79.3%) and was unexplained in 187 (20.7%). The incidence of sudden unexplained death (SUD) was 1.2 per 100,000 person-years for persons <35 years of age, and 2.0 per 100,000 person-years for those >= 35 years of age (p < 0.001). The incidence of fatal atherosclerotic coronary artery disease was 0.7 per 100,000 person-years for those < 35 years of age, and 13.7 per 100,000 person-years for those >= 35 years of age (p < 0.001).
Conclusions Prevention of sudden death in the young adult should focus on evaluation for causes known to be associated with SUD (e. g., primary arrhythmia) among persons <35 years of age, with an emphasis on atherosclerotic coronary disease in those >= 35 years of age. (J Am Coll Cardiol 2011;58:1254-61) (C) 2011 by the American College of Cardiology Foundation
C1 [Eckart, Robert E.] Brooke Army Med Ctr, Cardiac Arrhythmia Serv, Div Cardiovasc, San Antonio, TX 78234 USA.
[Shry, Eric A.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
[Burke, Allen P.; Pearse, Lisa A.; Potter, Robert N.; Tremaine, Ladd] Armed Forces Inst Pathol, Washington, DC 20306 USA.
[Avedissian, Lena; Huffer, Linda] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Stevenson, William G.] Brigham & Womens Hosp, Boston, MA 02115 USA.
RP Eckart, RE (reprint author), Brooke Army Med Ctr, Cardiac Arrhythmia Serv, Div Cardiovasc, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM robert.eckart@us.army.mil
NR 36
TC 93
Z9 94
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD SEP 13
PY 2011
VL 58
IS 12
BP 1254
EP 1261
DI 10.1016/j.jacc.2011.01.049
PG 8
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 816NP
UT WOS:000294609400012
PM 21903060
ER
PT J
AU Zheng, LQ
Li, ZR
Bourdo, S
Saini, V
Ryerson, C
Biris, AS
AF Zheng, Liqiu
Li, Zhongrui
Bourdo, Shawn
Saini, Viney
Ryerson, Charles
Biris, Alexandru S.
TI Hierarchical ZnO Structure with Superhydrophobicity and High Adhesion
SO CHEMPHYSCHEM
LA English
DT Article
DE adhesion; interfaces; nanostructures; superphydrophobicity; zinc oxide
ID ELECTROCHEMICAL DEPOSITION; SURFACES; WETTABILITY; INTERFACES; BEHAVIOR;
ARRAYS; FORCE; FILMS; WATER
C1 [Zheng, Liqiu; Li, Zhongrui; Bourdo, Shawn; Saini, Viney; Biris, Alexandru S.] Univ Arkansas Little Rock, Nanotechnol Ctr, Little Rock, AR 72204 USA.
[Ryerson, Charles] USA, Terr & Cryospher Sci Branch Cold Reg, Res & Engn Lab, Corps Engineers, Hanover, NH 03755 USA.
RP Zheng, LQ (reprint author), Univ Arkansas Little Rock, Nanotechnol Ctr, Little Rock, AR 72204 USA.
EM lxzheng@ualr.edu; zxli3@ualr.edu; axbiris@ualr.edu
RI Biris, Alexandru/A-8507-2010
FU DOD [W912HZ-09-2-0008]; Arkansas Science and Technology Authority (ASTA)
[08-CAT-03]
FX This research was partially supported by the DOD(Grant No.
W912HZ-09-2-0008). Also, financial support from the Arkansas Science and
Technology Authority (ASTA) grant # 08-CAT-03 is greatly appreciated.
NR 25
TC 0
Z9 0
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1439-4235
J9 CHEMPHYSCHEM
JI ChemPhysChem
PD SEP 12
PY 2011
VL 12
IS 13
BP 2411
EP 2413
DI 10.1002/cphc.201100314
PG 3
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 824XH
UT WOS:000295235000012
ER
PT J
AU Ayan, H
Yildirim, ED
Pappas, DD
Sun, W
AF Ayan, Halim
Yildirim, Eda D.
Pappas, Daphne D.
Sun, Wei
TI Development of a cold atmospheric pressure microplasma jet for freeform
cell printing
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID FABRICATION; MICROPATTERNS; DISCHARGE
AB An atmospheric pressure non-thermal microplasma jet (circle divide 50 mu m) was developed for localized functionalization of various substrates, including polymers, to allow maskless freeform cell printing. The applied microplasma jet power ranged from 0.1 to 0.2 W without causing any damage to the polyethylene substrate. The surface characterization results demonstrate that the microplasma treatment locally changes the surface roughness and the concentration of oxygen-containing functional groups on the polyethylene surface. The biological characterization confirms that the osteoblast cells attach and survive on the plasma activated line while untreated surfaces show almost no attachment and viability. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3638062]
C1 [Ayan, Halim] Murray State Univ, Dept Engn & Phys, Murray, KY 42071 USA.
[Yildirim, Eda D.] Univ Toledo, Dept Bioengn, Toledo, OH 43606 USA.
[Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Sun, Wei] Drexel Univ, Dept Mech Engn, Philadelphia, PA 19104 USA.
[Sun, Wei] Tsinghua Univ, Dept Mech Engn, Beijing 100084, Peoples R China.
RP Ayan, H (reprint author), Murray State Univ, Dept Engn & Phys, Murray, KY 42071 USA.
EM hayan@murraystate.edu; sunwei@drexel.edu
OI Pappas, Daphne/0000-0002-5746-8873
FU National Science Foundation
FX This study was funded in part by the National Science Foundation.
NR 30
TC 14
Z9 15
U1 3
U2 14
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 12
PY 2011
VL 99
IS 11
AR 111502
DI 10.1063/1.3638062
PG 3
WC Physics, Applied
SC Physics
GA 822HK
UT WOS:000295034400016
ER
PT J
AU O'Malley, PG
AF O'Malley, Patrick G.
TI Collaborative Care and the Medical Home A Good Match
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Editorial Material
ID RANDOMIZED CONTROLLED-TRIAL; HEART-FAILURE; CASE-MANAGEMENT; DEPRESSION
C1 [O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Gen Internal Med, Bethesda, MD USA.
RP O'Malley, PG (reprint author), Walter Reed Army Med Ctr, Dept Med, Div Gen Internal Med, 6900 Georgia Ave, Washington, DC 20307 USA.
EM pomalley@usuhs.mil
NR 12
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0003-9926
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD SEP 12
PY 2011
VL 171
IS 16
BP 1428
EP 1429
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 819KY
UT WOS:000294825100002
PM 21911625
ER
PT J
AU Sanamyan, T
Kanskar, M
Xiao, Y
Kedlaya, D
Dubinskii, M
AF Sanamyan, T.
Kanskar, M.
Xiao, Y.
Kedlaya, D.
Dubinskii, M.
TI High power diode-pumped 2.7-mu m Er3+:Y2O3 laser with nearly quantum
defect-limited efficiency
SO OPTICS EXPRESS
LA English
DT Article
ID MU-M; CERAMIC LASER; LEVEL; Y2O3; YAG
AB We report diode-pumped Er3+:Y2O3 ceramic laser with similar to 14 W of true CW output at similar to 2.7 mu m. This presents nearly ten-fold power increase with respect to previous best result with this laser material. We also believe this to be the highest power ever reported from Er3+-doped bulk crystalline laser operating in a similar to 3-mu m wavelength range. Power-scaled performance of 974-nm pumped Er3+:Y2O3 laser was achieved with the slope efficiency of similar to 26%. (C) 2011 Optical Society of America
C1 [Sanamyan, T.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA.
[Kanskar, M.; Xiao, Y.; Kedlaya, D.] Alfalight Inc, Madison, WI 53704 USA.
RP Sanamyan, T (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM tigran.sanamyan@arl.army.mil
NR 15
TC 25
Z9 25
U1 2
U2 14
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD SEP 12
PY 2011
VL 19
IS 19
BP A1082
EP A1087
DI 10.1364/OE.19.0A1082
PG 6
WC Optics
SC Optics
GA 818UL
UT WOS:000294781200007
PM 21935250
ER
PT J
AU Badger, CV
Richardson, JD
DaSilva, RL
Richards, MJ
Josleyn, MD
Dupuy, LC
Hooper, JW
Schmaljohn, CS
AF Badger, C. V.
Richardson, J. D.
DaSilva, R. L.
Richards, M. J.
Josleyn, M. D.
Dupuy, L. C.
Hooper, J. W.
Schmaljohn, C. S.
TI Development and application of a flow cytometric potency assay for DNA
vaccines
SO VACCINE
LA English
DT Article
DE Hemorrhagic fever with renal syndrome; Hantavirus; Venezuelan equine
encephalitis virus; Potency assay; Flow cytometry; DNA vaccine; Gene
gun; Electroporation
ID MONOCLONAL-ANTIBODIES; VIRUS
AB We have developed a rapid, reliable, and sensitive quantitative flow cytometric assay to measure the in vitro potency and stability of DNA vaccines to be delivered either by particle-mediated epidermal delivery (PMED) or by electroporation. The method involves transfecting cells with test DNA and comparing the measured antigen expression to that generated with expression from known quantities of reference material DNA. The assay was adapted for performance under Good Laboratory Practice (GLP) guidelines and was successfully utilized to perform potency testing in support of a Phase I study for two hantavirus DNA vaccines delivered by gene gun. The results from the potency assays conducted over a 24-month period using this method proved to be highly reproducible with high signal-to-noise ratios. The assay was also adapted to assess the in vitro potency and stability of a DNA vaccine for Venezuelan equine encephalitis virus that will be delivered by electroporation. Our results indicate that this assay can be readily applied to support potency and stability testing of numerous DNA vaccines delivered by various methods, including multiagent vaccines. Published by Elsevier Ltd.
C1 [Badger, C. V.; Richardson, J. D.; DaSilva, R. L.; Richards, M. J.; Josleyn, M. D.; Dupuy, L. C.; Hooper, J. W.; Schmaljohn, C. S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM connie.schmaljohn@amedd.army.mil
OI Hooper, Jay/0000-0002-4475-0415
FU Defense Threat Reduction Agency; Military Infectious Disease Research
Program
FX Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Army or the
Department of Defense. The research described herein was supported by
funding from the Defense Threat Reduction Agency and the Military
Infectious Disease Research Program.
NR 11
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD SEP 9
PY 2011
VL 29
IS 39
SI SI
BP 6728
EP 6735
DI 10.1016/j.vaccine.2010.12.053
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 828JL
UT WOS:000295497200003
PM 21219978
ER
PT J
AU Kissner, TL
Moisan, L
Mann, E
Alam, S
Ruthel, G
Ulrich, RG
Rebek, M
Rebek, J
Saikh, KU
AF Kissner, Teri L.
Moisan, Lionel
Mann, Enrique
Alam, Shahabuddin
Ruthel, Gordon
Ulrich, Robert G.
Rebek, Mitra
Rebek, Julius, Jr.
Saikh, Kamal U.
TI A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1
(IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin
B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID CLASS-II MOLECULES; MHC CLASS-II; INTENSIVE-CARE UNITS;
SIGNAL-TRANSDUCTION; ADAPTER PROTEIN; DENDRITIC CELLS; SHOCK-SYNDROME;
LETHAL SHOCK; T-CELLS; SUPERANTIGEN
AB Toxic shock syndrome (TSS) is a clinical consequence of the profound amplification of host pro-inflammatory cytokine signaling that results from staphylococcal enterotoxin (SE) exposure. We recently reported that MyD88(-/-) mice were resistant to SEA or SEB toxic shock and displayed reduced levels of pro-inflammatory cytokines in their serum. Here we report that SEB stimulation of total mononuclear cells up-regulated MyD88 in monocytes and T cells. Further, MyD88 gene silencing in primary human cells using siRNA prevented SEB or SEB plus lipopolysaccharide (LPS) induction of interleukin-1 beta (IL-1 beta) transcriptional activation, suggesting that MyD88-mediated signaling is an essential component of SEB toxicity. We synthesized small molecules that mimic the conserved BB-loop in the Toll/IL-1 receptor (TIR) domain of MyD88. In primary human cells, these mimetics attenuated SEB-induced pro-inflammatory cytokine production. SEB stimulation of primary cells with mimetic affected newly synthesized MyD88 and downstream signaling components. Furthermore, LPS-induced MyD88 signaling was likewise inhibited in a cell-based reporter assay. More importantly, administration of mimetic reduced cytokine responses and increased survivability in a murine SEB challenge model. Collectively, these results suggest that MyD88 BB-loop mimetics interfere with SEB-induced pro-inflammatory signaling and toxicity, thus offering a potential approach in the therapy of toxic shock.
C1 [Kissner, Teri L.; Alam, Shahabuddin; Ruthel, Gordon; Ulrich, Robert G.; Saikh, Kamal U.] USA, Dept Immunol, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Moisan, Lionel; Mann, Enrique; Rebek, Mitra; Rebek, Julius, Jr.] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA.
[Moisan, Lionel; Mann, Enrique; Rebek, Mitra; Rebek, Julius, Jr.] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.
RP Saikh, KU (reprint author), 1425 Porter St, Frederick, MD 21702 USA.
EM kamal.saikh@amedd.army.mil
RI Mann, Enrique /K-6594-2014
OI Mann, Enrique /0000-0002-2050-4295
FU Defense Threat Reduction Agency; Skaggs Institute; Spanish Ministerio de
Educacion y Ciencia
FX This work was supported by the Defense Threat Reduction Agency (to K. U.
S.) and the Skaggs Institute.; Supported by a Spanish Ministerio de
Educacion y Ciencia fellowship.
NR 34
TC 18
Z9 18
U1 0
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD SEP 9
PY 2011
VL 286
IS 36
BP 31385
EP 31396
DI 10.1074/jbc.M110.204982
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 814WI
UT WOS:000294487500033
PM 21693701
ER
PT J
AU Bedair, SS
Judy, D
Pulskamp, J
Polcawich, RG
Gillon, A
Hwang, E
Bhave, S
AF Bedair, Sarah S.
Judy, Daniel
Pulskamp, Jeffrey
Polcawich, Ronald G.
Gillon, Adam
Hwang, Eugene
Bhave, Sunil
TI High rejection, tunable parallel resonance in micromachined lead
zirconate titanate on silicon resonators
SO APPLIED PHYSICS LETTERS
LA English
DT Article
DE band-pass filters; band-stop filters; lead compounds; micromechanical
devices; resonator filters
ID FILTERS; COMPACT
AB This paper presents a micromachined lead zirconate titanate-on-silicon electromechanical resonator, tunable from series to parallel resonance, for either bandstop or bandpass filter applications. Scattering parameter measurements (9.2 V direct current (DC) bias) reveal bandstop rejection levels > 109 dB at 59.74 MHz and passband loss of 40 dB with a -20-dB bandwidth of 25 kHz (0.042%). These compare within 5-dB of the models. Parallel resonance is also observed for an alternate mechanical mode at 182.8 MHz with a 1.5 V DC bias with a rejection of 54.7 dB, a -20 dB bandwidth of 41 kHz (0.022%). This mode is tunable with the electric field to show series resonance. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3636432]
C1 [Bedair, Sarah S.; Judy, Daniel; Pulskamp, Jeffrey; Polcawich, Ronald G.; Gillon, Adam] USA, Res Lab, Adelphi, MD 20783 USA.
[Hwang, Eugene; Bhave, Sunil] Cornell Univ, OxideMEMS Lab, Ithaca, NY 14853 USA.
RP Bedair, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM sarahbedair@gmail.com
RI Bedair, Sarah/D-9130-2013
NR 12
TC 7
Z9 7
U1 0
U2 3
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 5
PY 2011
VL 99
IS 10
AR 103509
DI 10.1063/1.3636432
PG 3
WC Physics, Applied
SC Physics
GA 818GG
UT WOS:000294739100061
ER
PT J
AU Warner, CH
Appenzeller, GN
Mobbs, A
Parker, JR
Warner, CM
Grieger, T
Hoge, CW
AF Warner, Christopher H.
Appenzeller, George N.
Mobbs, Angela
Parker, Jessica R.
Warner, Carolynn M.
Grieger, Thomas
Hoge, Charles W.
TI Effectiveness of battlefield-ethics training during combat deployment: a
programme assessment
SO LANCET
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; PREVALENCE; CHECKLIST
AB Background Breakdowns in the ethical conduct of soldiers towards non-combatants on the battlefield are of grave concern in war. Evidence-based training approaches to prevent unethical conduct are scarce. We assessed the effectiveness of battlefield-ethics training and factors associated with unethical battlefield conduct.
Methods The training package, based on movie vignettes and leader-led discussions, was administered 7 to 8 months into a 15-month high-intensity combat deployment in Iraq, between Dec 11,2007, and Jan 30,2008. Soldiers from an infantry brigade combat team (total population about 3500) were randomly selected, on the basis of company and the last four digits of each soldier's social security number, and invited to complete an anonymous survey 3 months after completion of the training. Reports of unethical behaviour and attitudes in this sample were compared with a randomly selected pre-training sample from the same brigade. The response patterns for ethical behaviour and reporting of ethical violations were analysed with chi-square analyses. We developed two logistic regression models using self-reported unethical behaviours as dependent variables. Factors associated with unethical conduct, including combat experiences and post-traumatic stress disorder (PTSD), were assessed with validated scales.
Findings Of 500 randomly selected soldiers 421 agreed to participate in the anonymous post-training survey. A total of 397 soldiers of the same brigade completed the pre-training survey. Training was associated with significantly lower rates of unethical conduct of soldiers and greater willingness to report and address misconduct than in those before training. For example, reports of unnecessary damage or destruction of private property decreased from 13.6% (54 of 397; 95% CI 10.2-17.0) before training to 5.0% (21 of 421; 2.9-7.1) after training (percent difference -63.2%; p<0.0001), and willingness to report a unit member for mistreatment of a non-combatant increased from 36.0% (143 of 397; 31.3-40.7) to 58.9% (248 of 421; 54.2-63.6; percent difference 63.6; p<0.0001). Nearly all participants (410 [97%]) reported that training made it clear how to respond towards non-combatants. Combat frequency and intensity was the strongest predictor of unethical behaviour; PTSD was not a significant predictor of unethical behaviour after controlling for combat experiences.
Interpretation Leader-led battlefield ethics training positively influenced soldiers' understanding of how to interact with and treat non-combatants, and reduced reports of ethical misconduct. Unethical battlefield conduct was associated with high-intensity combat but not with PTSD.
C1 [Warner, Christopher H.; Appenzeller, George N.] USA Med Act Alaska, Ft Wainwright, AK 99703 USA.
[Warner, Christopher H.] Command & Gen Staff Coll, Ft Leavenworth, KS USA.
[Mobbs, Angela] 5th Special Forces Grp, Ft Bragg, NC USA.
[Parker, Jessica R.] Winn Army Community Hosp, Warrior Restorat Ctr, Ft Stewart, GA USA.
[Warner, Carolynn M.] Munson Army Hlth Clin, Ft Leavenworth, KS USA.
[Grieger, Thomas] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA.
RP Warner, CH (reprint author), USA Med Act Alaska, Ft Wainwright, AK 99703 USA.
EM christopher.h.warner@us.army.mil
NR 24
TC 8
Z9 8
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD SEP 3
PY 2011
VL 378
IS 9794
BP 915
EP 924
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 818XZ
UT WOS:000294791300032
PM 21890056
ER
PT J
AU Nunn, PV
Reeves, WK
Utter, CM
AF Nunn, Peter V.
Reeves, Will K.
Utter, Curtis M.
TI NEW RECORDS FOR MICRONESIAN MOSQUITOES
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Aedes albopictus; Anopheles campestris; Republic of the Marshall
Islands; Guam
ID AEDES-ALBOPICTUS; GUAM; VECTOR; ISLANDS
AB The mosquito fauna of Micronesia is diverse and subject to introductions of exotic species and local extinctions. We report on 2 recently identified populations of exotic mosquitoes, Aedes albopictus and Anopheles campestris, to the Republic of the Marshall Islands and Guam.
C1 [Reeves, Will K.] USAF Sch Aerosp Med USAFSAM PHR, Wright Patterson AFB, OH 45433 USA.
[Nunn, Peter V.; Utter, Curtis M.] USA, Publ Hlth Command Reg Pacific, Unit 45006, MCHB AJ TLD, APO, AP 96343 USA.
RP Reeves, WK (reprint author), USAF Sch Aerosp Med USAFSAM PHR, 2947 5th St, Wright Patterson AFB, OH 45433 USA.
NR 18
TC 0
Z9 1
U1 2
U2 2
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
EI 1943-6270
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD SEP
PY 2011
VL 27
IS 3
BP 300
EP 302
DI 10.2987/11-6120.1
PG 3
WC Entomology
SC Entomology
GA 973FK
UT WOS:000306344300014
PM 22017093
ER
PT J
AU Kessler, JL
AF Kessler, Joshua L.
TI THE GOLDSTONE REPORT: POLITICIZATION OF THE LAW OF ARMED CONFLICT AND
THOSE LEFT BEHIND
SO MILITARY LAW REVIEW
LA English
DT Article
AB I don't think any country would find it acceptable to have missiles raining down on the heads of their citizens. The first job of any nation-state is to protect its citizens. And so I can assure you that if ... somebody was sending rockets into my house, where my two daughters sleep at night, I'm going to do everything in my power to stop that. And I would expect Israelis to do the same thing.(1)
C1 [Kessler, Joshua L.] USA, Criminal Invest Div, Ft Belvoir, VA USA.
RP Kessler, JL (reprint author), US Army N 5th Army, Off Staff Judge Advocate, Def Support Civil Author Sect, Ft Sam Houston, TX USA.
NR 82
TC 1
Z9 1
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD FAL
PY 2011
VL 209
BP 69
EP 121
PG 53
WC Law
SC Government & Law
GA 931KU
UT WOS:000303219600002
ER
PT J
AU Kirchmaier, CT
AF Kirchmaier, Charles T.
TI TREATING THE SYMPTOMS BUT NOT THE DISEASE: A CALL TO REFORM FALSE CLAIMS
ACT ENFORCEMENT
SO MILITARY LAW REVIEW
LA English
DT Article
ID LITIGATION
C1 [Kirchmaier, Charles T.] Multinatl Corps Iraq, Baghdad, Iraq.
[Kirchmaier, Charles T.] XVIII Airborne Corps, Baghdad, Iraq.
[Kirchmaier, Charles T.] US Army, Battle Command Training Program, Ft Leavenworth, KS USA.
[Kirchmaier, Charles T.] 75th Ranger Regiment, Ft Benning, GA USA.
[Kirchmaier, Charles T.] US Dept Def, Off Gen Counsel, Washington, DC 20305 USA.
[Kirchmaier, Charles T.] Contract Appeals Div, Arlington, VA USA.
NR 49
TC 1
Z9 1
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD FAL
PY 2011
VL 209
BP 186
EP 240
PG 55
WC Law
SC Government & Law
GA 931KU
UT WOS:000303219600004
ER
PT J
AU Sameit, MD
AF Sameit, Mark D.
TI ROCK THE CASBAH: RAGE AND REBELLION ACROSS THE ISLAMIC WORLD
SO MILITARY LAW REVIEW
LA English
DT Book Review
AB For a decade, the outside world was so preoccupied with its "war on terrorism" that it gave little credence to efforts among Muslims to deal with the overlapping problems-autocratic regimes and extremist movements-that fed off each other.(2)
C1 [Sameit, Mark D.] USA, 60th Judge Advocate Officer Grad Course, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA.
NR 24
TC 0
Z9 0
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD FAL
PY 2011
VL 209
BP 241
EP 249
PG 9
WC Law
SC Government & Law
GA 931KU
UT WOS:000303219600005
ER
PT J
AU Tserendorj, A
Anceno, AJ
Houpt, ER
Icenhour, CR
Sethabutr, O
Mason, CS
Shipin, OV
AF Tserendorj, Ariuntuya
Anceno, Alfredo J.
Houpt, Eric R.
Icenhour, Crystal R.
Sethabutr, Orntipa
Mason, Carl S.
Shipin, Oleg V.
TI Molecular Techniques in Ecohealth Research Toolkit: Facilitating
Estimation of Aggregate Gastroenteritis Burden in an Irrigated Periurban
Landscape
SO ECOHEALTH
LA English
DT Article
DE molecular techniques; indicator organisms; waterborne gastroenteritis;
disease burden; microbial health risks; tropical periurban landscape
ID REAL-TIME PCR; ENVIRONMENTAL WATER SAMPLES; WASTE STABILIZATION PONDS;
ADJUSTED LIFE-YEARS; HEPATITIS-A VIRUS; CRYPTOSPORIDIUM-PARVUM;
RISK-ASSESSMENT; HEALTH-RISKS; QUANTIFICATION; PATHOGENS
AB Assessment of microbial hazards associated with certain environmental matrices, livelihood strategies, and food handling practices are constrained by time-consuming conventional microbiological techniques that lead to health risk assessments of narrow geographic or time scope, often targeting very few pathogens. Health risk assessment based on one or few indicator organisms underestimates true disease burden due a number of coexisting causative pathogens. Here, we employed molecular techniques in a survey of Cryptosporidium parvum, Giardia lamblia, Campylobacter jejuni, Escherichia coli O157:H7, Listeria monocytogenes, Salmonella spp., Shigella spp., Vibrio cholera, and Rotavirus A densities in canal water with respect to seasonality and spatial distribution of point-nonpoint pollution sources. Three irrigational canals stretching across nearly a 150-km(2) periurban landscape, traditionally used for agricultural irrigation but function as vital part of municipal wastewater stabilization in recent years, were investigated. Compiled stochastic data (pathogen concentration, susceptible populations) and literature-obtained deterministic data (pathogen dose-response model parameter values) were used in estimating waterborne gastroenteritis burden. Exposure scenarios include swimming or fishing, consuming canal water-irrigated vegetables, and ingesting or inhaling water aerosols while working in canal water-irrigated fields. Estimated annual gastroenteritis burden due individual pathogens among the sampling points was -10.6log(10) to -2.2log(10) DALYs. Aggregated annual gastroenteritis burden due all the target pathogens per sampling point was -3.1log(10) to -1.9log(10) DALYs, far exceeding WHO acceptable limit of -6.0log(10) DALYs. The present approach will facilitate the comprehensive collection of surface water microbiological baseline data and setting of benchmarks for interventions aimed at reducing microbial hazards in similar landscapes worldwide.
C1 [Tserendorj, Ariuntuya; Anceno, Alfredo J.; Shipin, Oleg V.] Asian Inst Technol, WHO Collaborating Ctr Water Supply & Waste Dispos, Klongluang 12120, Pathumthani, Thailand.
[Houpt, Eric R.] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA.
[Icenhour, Crystal R.] Phthisis Diagnost, Charlottesville, VA 22903 USA.
[Sethabutr, Orntipa; Mason, Carl S.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
RP Shipin, OV (reprint author), Asian Inst Technol, WHO Collaborating Ctr Water Supply & Waste Dispos, POB 4, Klongluang 12120, Pathumthani, Thailand.
EM oshipin@ait.ac.th
OI MASON, CARL/0000-0002-3676-2811
FU US National Institutes of Health; EEM-AIT
FX We acknowledge the financial support from the US National Institutes of
Health and in part from the EEM-AIT internal research fellowship to A.
Tserendorj. We thank the AIT Geoinformatics Laboratory and the Thailand
National Center for Genetic Engineering and Biotechnology for the
logistical support. We also thank W. Jiamjitrpanich, M.B.C. Diallo and
A. Sapkota (EEM-AIT) for the technical assistance in surface water
processing, and L Kittigul (Public Health, Mahidol University) and S.
Silapong (AFRIMS) for the technical advice and assistance in molecular
assays.
NR 46
TC 3
Z9 3
U1 3
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1612-9202
J9 ECOHEALTH
JI EcoHealth
PD SEP
PY 2011
VL 8
IS 3
BP 349
EP 364
DI 10.1007/s10393-011-0724-8
PG 16
WC Biodiversity Conservation; Ecology; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 904HD
UT WOS:000301184200010
PM 22146856
ER
PT J
AU Noh, Y
Choi, KK
Lee, I
Gorsich, D
Lamb, D
AF Noh, Yoojeong
Choi, Kyung K.
Lee, Ikjin
Gorsich, David
Lamb, David
TI Reliability-Based Design Optimization With Confidence Level for
Non-Gaussian Distributions Using Bootstrap Method
SO JOURNAL OF MECHANICAL DESIGN
LA English
DT Article
DE reliability-based design optimization; input statistical model;
confidence level; non-Gaussian distribution; bootstrap method
ID INVERSE ANALYSIS METHOD; DIMENSION REDUCTION; COPULA; PARAMETERS;
INTERVALS; SELECTION; RETURNS; SYSTEMS
AB For reliability-based design optimization (RBDO), generating an input statistical model with confidence level has been recently proposed to offset inaccurate estimation of the input statistical model with Gaussian distributions. For this, the confidence intervals for the mean and standard deviation are calculated using Gaussian distributions of the input random variables. However, if the input random variables are non-Gaussian, use of Gaussian distributions of the input variables will provide inaccurate confidence intervals, and thus yield an undesirable confidence level of the reliability-based optimum design meeting the target reliability beta(t). In this paper, an RBDO method using a bootstrap method, which accurately calculates the confidence intervals for the input parameters for non-Gaussian distributions, is proposed to obtain a desirable confidence level of the output performance for non-Gaussian distributions. The proposed method is examined by testing a numerical example and M1A1 Abrams tank roadarm problem. [DOI:10.1115/1.4004545]
C1 [Noh, Yoojeong; Choi, Kyung K.; Lee, Ikjin] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
[Gorsich, David; Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA.
RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
EM noh@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu;
ilee@engineering.uiowa.edu; david.gorsich@us.army.mil;
david.lamb@us.army.mil
RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008; Noh,
Yoojeong/E-9833-2015
OI Choi, Kyung/0000-0003-2384-6220;
FU Automotive Research Center; U.S. Army TARDEC; ARO [W911NF-09-1-0250];
through the National Research Foundation of Korea (NRF); Ministry of
Education, Science and Technology [R32-2008-000-10161-0]
FX Research is primarily supported by the Automotive Research Center, which
is sponsored by the U.S. Army TARDEC and ARO Project W911NF-09-1-0250.
This research was also partially supported by the World Class University
Program through the National Research Foundation of Korea (NRF) grant
funded by the Ministry of Education, Science and Technology (Grant
Number R32-2008-000-10161-0 in 2009). These supports are greatly
appreciated.
NR 37
TC 8
Z9 8
U1 0
U2 12
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1050-0472
J9 J MECH DESIGN
JI J. Mech. Des.
PD SEP
PY 2011
VL 133
IS 9
AR 091001
DI 10.1115/1.4004545
PG 12
WC Engineering, Mechanical
SC Engineering
GA 910OU
UT WOS:000301649900002
ER
PT J
AU Hammond, RT
AF Hammond, Richard T.
TI Variable charge and massless photons
SO PHYSICS ESSAYS
LA English
DT Article
DE Conservation Laws
AB It is routinely stated that conservation of electric charge follows from Maxwell's equations. On the other hand, if charge is not conserved, then it is usually stated that the photon acquires a mass. It is shown that neither of these statements is true, and the equations with variable charge are presented. (C) 2011 Physics Essays Publication. [DOI: 10.4006/1.3607248]
C1 [Hammond, Richard T.] Univ N Carolina Chapel Hill, Dept Phys, Res Triangle Pk, NC 27703 USA.
[Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27703 USA.
RP Hammond, RT (reprint author), Univ N Carolina Chapel Hill, Dept Phys, Res Triangle Pk, NC 27703 USA.
EM rhammond@email.unc.edu
NR 4
TC 0
Z9 0
U1 0
U2 1
PU PHYSICS ESSAYS PUBLICATION
PI OTTAWA
PA PO BOX 8141 STATION T, OTTAWA, ONTARIO K1G 3H6, CANADA
SN 0836-1398
J9 PHYS ESSAYS
JI Phys. Essays
PD SEP
PY 2011
VL 24
IS 3
BP 379
EP 380
DI 10.4006/1.3607248
PG 2
WC Physics, Multidisciplinary
SC Physics
GA 879YW
UT WOS:000299371700008
ER
PT J
AU Sutter, DE
Bradshaw, LU
Simkins, LH
Summers, AM
Atha, M
Elwood, RL
Robertson, JL
Murray, CK
Wortmann, GW
Hospenthal, DR
AF Sutter, Deena E.
Bradshaw, Linda U.
Simkins, Lucas H.
Summers, Amy M.
Atha, Michael
Elwood, Robert L.
Robertson, Janelle L.
Murray, Clinton K.
Wortmann, Glenn W.
Hospenthal, Duane R.
TI High Incidence of Multidrug-Resistant Gram-Negative Bacteria Recovered
from Afghan Patients at a Deployed US Military Hospital
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID ACINETOBACTER-BAUMANNII; IRAQ; COLONIZATION; PERSONNEL; FACILITY
AB OBJECTIVE. To investigate potential sources and risks associated with multidrug-resistant (MDR) bacteria in a deployed US military hospital.
DESIGN. Retrospective analysis of factors associated with recovery of MDR bacteria, supplemented by environmental sampling.
SETTING. The largest US military hospital in Afghanistan.
PATIENTS. US and Afghan patients with positive bacterial culture results, from September 2007 through August 2008.
METHODS. Microbiologic, demographic, and clinical data were analyzed. Potential risk factors included admission diagnosis or mechanism of injury, length of stay, gender, age, and nationality (US or Afghan). Environmental sampling of selected hospital high-touch surfaces and equipment was performed to help elucidate whether environmental MDR bacteria were contributing to nosocomial spread.
RESULTS. A total of 266 patients had 411 bacterial isolates that were identified during the study period, including 211 MDR bacteria (51%). Gram-negative bacteria were common among Afghan patients (241 [76%] of 319), and 70% of these were classified as MDR. This included 58% of bacteria recovered from Afghan patients within 48 hours of hospital admission. The most common gram-negative bacteria were Escherichia coli (53% were MDR), Acinetobacter (90% were MDR), and Klebsiella (63% were MDR). Almost one-half of potential extended-spectrum beta-lactamase (ESBL) producers were community acquired. Of 100 environmental swab samples, 18 yielded MDR bacteria, including 10 that were Acinetobacter, but no potential ESBL-producing bacteria.
CONCLUSIONS. Gram-negative bacteria from Afghan patients had high rates of antimicrobial resistance. Patients experiencing complex trauma and prolonged hospital stays likely contribute to the presence of MDR bacteria in this facility. However, many of these patients had community-acquired cases, which implies high rates of colonization prior to hospital admission. Infect Control Hosp Epidemiol 2011;32(9):854-860
C1 [Sutter, Deena E.; Bradshaw, Linda U.; Elwood, Robert L.] Wilford Hall USAF Med Ctr, Dept Pediat, Lackland AFB, TX USA.
[Summers, Amy M.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA.
[Summers, Amy M.] Walter Reed Army Med Ctr, Dept Med, Area Lab Support, Washington, DC 20307 USA.
[Atha, Michael] Dept Med, Travis AFB, CA USA.
[Robertson, Janelle L.] Elgin Hosp, Dept Med, Eglin AFB, FL USA.
[Murray, Clinton K.; Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA.
[Wortmann, Glenn W.] Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA.
RP Sutter, DE (reprint author), USAF, MC, Dept Pediat, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM deena.sutter@amedd.army.mil
RI Mavoa, Suzanne/B-5372-2010
NR 13
TC 20
Z9 21
U1 0
U2 4
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD SEP
PY 2011
VL 32
IS 9
BP 854
EP 860
DI 10.1086/661284
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 876BW
UT WOS:000299083000004
PM 21828965
ER
PT J
AU Liu, YK
Chang, X
Jin, DG
He, RQ
Sun, HC
Zheng, YC
AF Liu, Yike
Chang, Xu
Jin, Degang
He, Ruiqing
Sun, Hongchuan
Zheng, Yingcai
TI Reverse time migration of multiples for subsalt imaging
SO GEOPHYSICS
LA English
DT Article
AB Some hydrocarbon reservoirs are trapped beneath salt bodies, where seismic imaging is greatly challenged due to poor illumination. Multiple reflections have different propagation wave paths from primary reflections and thus can be used to complement the illuminations where primary reflections from beneath the salt are not acquired. Consequently, migration of multiples can sometimes provide better subsalt images compared to conventional migration which uses primary reflections only. In this paper, we propose to modify conventional reverse time migration so that multiples can be used as constructive reflection energy for subsalt imaging. This new approach replaces the impulsive source wavelet with the recorded data containing both primaries and multiples and uses predicted multiples as the input data instead of primary reflections. In the reverse time migration process, multiples recorded on the surface are extrapolated backward in time to each depth level, and the observed data with both primaries and multiples are extrapolated forward in time to the same depth levels, followed by a crosscorrelation imaging condition. A numerical test on the Sigsbee2B data set shows that a wider coverage and a more balanced illumination of the subsurface can be achieved by migration of multiples compared with conventional migration of primary reflections. This example demonstrates that reverse time migration of multiples might be a promising method for complex subsalt imaging.
C1 [Liu, Yike; Chang, Xu] Chinese Acad Sci, Inst Geol & Geophys, Beijing, Peoples R China.
[Jin, Degang] Sichuan Geophys Co, CNPC, Chengdu, Peoples R China.
[He, Ruiqing] USA, Paulsson Inc, Los Angeles, CA USA.
[Sun, Hongchuan] Univ Utah, Houston, TX USA.
[Zheng, Yingcai] MIT, Dept Earth Atmospher & Planetary Sci, Cambridge, MA USA.
RP Liu, YK (reprint author), Chinese Acad Sci, Inst Geol & Geophys, Beijing, Peoples R China.
EM ykliu@mail.igcas.ac.cn; changxu@mail.igcas.ac.cn; degang.jin@gmail.com;
ruiqing.he@paulsson.com; hongchuan.sun@exxonmobil.com; yczheng@mit.edu
FU National Nature Science Foundation of China [40930421, 40830422,
40874068]; National Basic Research Program of China (973 Program)
[2009CB219404]
FX We thank Gerard T. Schuster and Yi Luo for their helpful suggestions and
insightful comments. We are grateful to Isabelle Lecomte, Samuel Gray,
Faqi Liu, and Clement Kostov whose constructive comments improved this
paper. We would like to thank SMAART JV consortium for offering
Sigsbee2B data. The research was funded by the National Nature Science
Foundation of China (Grant No. 40930421, 40830422, 40874068) and the
National Basic Research Program of China (973 Program, grant No.
2009CB219404).
NR 31
TC 35
Z9 39
U1 3
U2 10
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
J9 GEOPHYSICS
JI Geophysics
PD SEP-OCT
PY 2011
VL 76
IS 5
BP WB209
EP WB216
DI 10.1190/GEO2010-0312.1
PG 8
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 860KC
UT WOS:000297946200045
ER
PT J
AU Andreotti, RF
Lee, SI
Allison, SOD
Bennett, GL
Brown, DL
Dubinsky, T
Glanc, P
Javitt, MC
Mitchell, DG
Podrasky, AE
Shipp, TD
Siegel, CL
Wong-You-Cheong, JJ
Zelop, CM
AF Andreotti, Rochelle F.
Lee, Susanna I.
Allison, Sandra O. DeJesus
Bennett, Genevieve L.
Brown, Douglas L.
Dubinsky, Theodore
Glanc, Phyllis
Javitt, Marcia C.
Mitchell, Donald G.
Podrasky, Ann E.
Shipp, Thomas D.
Siegel, Cary Lynn
Wong-You-Cheong, Jade J.
Zelop, Carolyn M.
TI ACR Appropriateness Criteria (R) Acute Pelvic Pain in the Reproductive
Age Group
SO ULTRASOUND QUARTERLY
LA English
DT Article
DE appropriateness criteria; pelvic pain; acute; imaging; diagnosis
ID DEEP VENOUS THROMBOSIS; HELICAL COMPUTED-TOMOGRAPHY; ACUTE APPENDICITIS;
ADNEXAL TORSION; INFLAMMATORY-DISEASE; PREGNANT PATIENTS; SUSPECTED
APPENDICITIS; SONOGRAPHIC FINDINGS; RADIATION-EXPOSURE; ECTOPIC
PREGNANCY
AB Premenopausal women who present with acute pelvic pain frequently pose a diagnostic dilemma, exhibiting nonspecific signs and symptoms, the most common being nausea, vomiting, and leukocytosis. Diagnostic considerations encompass multiple organ systems, including obstetric, gynecologic, urologic, gastrointestinal, and vascular etiologies. The selection of imaging modality is determined by the clinically suspected differential diagnosis. Thus, a careful evaluation of such a patient should be performed and diagnostic considerations narrowed before a modality is chosen. Transvaginal and transabdominal pelvic sonography is the modality of choice when an obstetric or gynecologic abnormality is suspected, and computed tomography is more useful when gastrointestinal or genitourinary pathology is more likely. Magnetic resonance imaging, when available in the acute setting, is favored over computed tomography for assessing pregnant patients for nongynecologic etiologies because of the lack of ionizing radiation. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every two years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment.
C1 [Andreotti, Rochelle F.] Vanderbilt Univ, Med Ctr, Dept Radiol, Nashville, TN 37232 USA.
[Lee, Susanna I.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA.
[Allison, Sandra O. DeJesus] Georgetown Univ Hosp, Dept Radiol, Washington, DC 20007 USA.
[Bennett, Genevieve L.] NYU Med Ctr, Dept Radiol, New York, NY 10016 USA.
[Brown, Douglas L.] Mayo Clin, Dept Radiol, Rochester, MN USA.
[Dubinsky, Theodore] Univ Washington, Sch Med, Dept Radiol, Seattle, WA 98195 USA.
[Glanc, Phyllis] Sunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON M4N 3M5, Canada.
[Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA.
[Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Dept Radiol, Philadelphia, PA 19107 USA.
[Podrasky, Ann E.] Baptist Hosp Miami, S Miami Ctr Women & Infants, Dept Radiol, Miami, FL USA.
[Shipp, Thomas D.] Amer Coll Obstetricians & Gynecologists, Washington, DC USA.
[Shipp, Thomas D.] Diagnost Ultrasound Associates, Boston, MA USA.
[Siegel, Cary Lynn] Mallinckrodt Inst Radiol, Dept Radiol, St Louis, MO USA.
[Wong-You-Cheong, Jade J.] Univ Maryland, Sch Med, Dept Diagnost Radiol, Baltimore, MD 21201 USA.
[Zelop, Carolyn M.] Univ Connecticut, Sch Med, Dept Radiol, Farmington, CT USA.
RP Andreotti, RF (reprint author), Amer Coll Radiol, Dept Qual & Safety, 1891 Preston White Dr, Reston, VA 20191 USA.
EM acr_ac@acr.org
NR 53
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0894-8771
J9 ULTRASOUND Q
JI Ultrasound Q.
PD SEP
PY 2011
VL 27
IS 3
BP 205
EP 210
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 854XF
UT WOS:000297527400008
PM 21873877
ER
PT J
AU Blaylock, JM
Maranich, A
Bauer, K
Nyakoe, N
Waitumbi, J
Martinez, LJ
Lynch, J
AF Blaylock, Jason M.
Maranich, Ashley
Bauer, Kristen
Nyakoe, Nancy
Waitumbi, John
Martinez, Luis J.
Lynch, Julia
TI The seroprevalence and seroincidence of dengue virus infection in
western Kenya
SO TRAVEL MEDICINE AND INFECTIOUS DISEASE
LA English
DT Article
DE Dengue virus; Seroprevalence; Kenya
ID FEVER; ELISA; ASSAY; NIGERIA; HUMANS; IMPACT
AB Epidemics of dengue fever have been documented throughout the African continent over the past several decades, however little is known about the prevalence or incidence of dengue virus infection in the absence of an outbreak. No studies have analyzed the prevalence of dengue infection in western Kenya to date. This study describes the seroincidence and seroprevalence of dengue infection in western Kenya. Banked sera obtained from 354 healthy, afebrile children ages 12-47 months from Kisumu District, Kenya, were analyzed for antibodies to dengue virus using an IgG indirect ELISA. We found a seroprevalence of 1.1% (4 of 354 samples) and incidence of 8.5 seroconversions per 1000 persons per year in this study population. This appears to be similar to that previously reported in coastal regions of the country outside of known epidemic periods. Since there has never been a reported dengue epidemic in western Kenya, continued investigation and evaluation in a patient population presenting with fever is necessary to further confirm this finding. Published by Elsevier Ltd.
C1 [Blaylock, Jason M.] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA.
[Maranich, Ashley] San Antonio Mil Med Ctr N, Brooke Army Med Ctr, Dept Pediat Infect Dis, Ft Sam Houston, TX 78234 USA.
[Bauer, Kristen; Martinez, Luis J.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA.
[Nyakoe, Nancy; Waitumbi, John] USA, Med Res Unit Kenya, Walter Reed Project, Kisumu, Kenya.
[Lynch, Julia] MRMC RTI, Ft Detrick, MD 21702 USA.
RP Blaylock, JM (reprint author), Walter Reed Army Med Ctr, Dept Infect Dis, 6900 Georgia Ave, Washington, DC 20307 USA.
EM jason.blaylock@us.army.mil; ashley.maranich@iraq.centcom.mil;
kristen.m.bauer@us.army.mil; nnyakoe@wrp-ksm.org; jwaitumbi@wrp-ksm.org;
luis.j.martinez@us.army.mil; julia.lynch@us.army.mil
RI Valle, Ruben/A-7512-2013
NR 18
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1477-8939
J9 TRAVEL MED INFECT DI
JI Travel Med. Infect. Dis.
PD SEP
PY 2011
VL 9
IS 5
BP 246
EP 248
DI 10.1016/j.tmaid.2011.06.005
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 858VR
UT WOS:000297831800005
PM 21778117
ER
PT J
AU Rathbone, CR
Yamanouchi, K
Chen, XYK
Nevoret-Bell, CJ
Rhoads, RP
Allen, RE
AF Rathbone, Christopher R.
Yamanouchi, Keitaro
Chen, Xiaoyu K.
Nevoret-Bell, Cedrine J.
Rhoads, Robert P.
Allen, Ronald E.
TI Effects of transforming growth factor-beta (TGF-beta 1) on satellite
cell activation and survival during oxidative stress
SO JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
LA English
DT Article
DE Satellite cell; Transforming growth factor; Skeletal muscle; Quiescence;
Oxidative stress
ID MUSCLE STEM-CELLS; SKELETAL-MUSCLE; SELF-RENEWAL; IN-VITRO; MYOBLAST
TRANSPLANTATION; REGENERATIVE CAPACITY; MYOSTATIN GENE; PROLIFERATION;
EXPRESSION; DIFFERENTIATION
AB The regulation of adult skeletal muscle repair and regeneration is largely due to the contribution of resident adult myogenic precursor cells called satellite cells. The events preceding their participation in muscle repair include activation (exit from quiescence), proliferation, and differentiation. This study examined the effects of transforming growth factor-beta (TGF-beta 1) on satellite cell activation, determined whether TGF-beta 1 could maintain quiescence in the presence of hepatocyte growth factor (HGF), and whether the regulation of satellite cell activation with TGF-beta 1 improves the ability of satellite cells to withstand oxidative stress. The addition of TGF-beta 1 during early satellite cell activation (0-48 h) or during the proliferative phase (48-96 h) maintained and induced satellite cell quiescence, respectively, as determined by myogenic differentiation (MyoD) protein expression. TGF-beta 1 also attenuated satellite cell activation when used with HGF. Finally, the role of quiescence in protecting cells against oxidative stress was examined. TGF-beta 1 treatment and the low pH satellite cell preparation procedure, a technique that forestalls spontaneous activation in vitro, both enhanced survival of cultured satellite cells following hydrogen peroxide treatment. These findings indicate that TGF-beta 1 is capable of maintaining and inducing satellite cell quiescence and suggest methods to maintain satellite cell quiescence may improve their transplantation efficiency.
C1 [Rathbone, Christopher R.; Chen, Xiaoyu K.] USA, Inst Surg Res, San Antonio, TX 78234 USA.
[Rathbone, Christopher R.; Yamanouchi, Keitaro; Nevoret-Bell, Cedrine J.; Rhoads, Robert P.; Allen, Ronald E.] Univ Arizona, Dept Anim Sci, Muscle Biol Grp, Tucson, AZ 85721 USA.
[Chen, Xiaoyu K.] Wake Forest Inst Regenerat Med, Winston Salem, NC USA.
RP Rathbone, CR (reprint author), USA, Inst Surg Res, BHT1,Bldg 3611,3698 Chambers Pass, San Antonio, TX 78234 USA.
EM chris.rathbone@us.army.mil
RI Rhoads, Robert/F-2861-2016
OI Rhoads, Robert/0000-0002-5205-5834
FU National Institutes of Health (NIH) [AR053780]; Armed Forces Institute
of Regenerative Medicine; Arizona Agriculture Experiment Station; U.S.
Department of Agriculture National Research Initiative
[2005-35206-15255]; Muscular Dystrophy Association [MDA3685]
FX This work was supported by the National Institutes of Health (NIH) Grant
AR053780 (CR); a post-doctoral fellowship from the Armed Forces
Institute of Regenerative Medicine, administered through Wake Forest
Institute of Regenerative Medicine, Winston-Salem, NC (XC); the Arizona
Agriculture Experiment Station; and grants from the U.S. Department of
Agriculture National Research Initiative Competitive Grant
2005-35206-15255 and Muscular Dystrophy Association Grant MDA3685 (RA).
The opinions or assertions contained herein are the private views of the
author and are not to be construed as official or as reflecting the
views of the Department of the Army or the Department of Defense.
NR 50
TC 8
Z9 11
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0142-4319
J9 J MUSCLE RES CELL M
JI J. Muscle Res. Cell Motil.
PD SEP
PY 2011
VL 32
IS 2
BP 99
EP 109
DI 10.1007/s10974-011-9255-8
PG 11
WC Cell Biology
SC Cell Biology
GA 858ME
UT WOS:000297801300005
PM 21823037
ER
PT J
AU Carey, DR
AF Carey, David R.
TI Tobyhanna Army Depot Automated Test System Modernization
SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE
LA English
DT Article
DE Automatic test equipment; Automatic testing; Maintenance engineering; US
Department of Defense
AB During the last four decades the number of Automated Test Systems (ATS) has experienced tremendous growth at Tobyhanna Army Depot (TYAD). This is characterized in the proliferation through Base Realignment and Closure acquisition and in-house development of a wide variety of general and special-purpose ATS - to date, there are 94 unique ATS and a total of 230 ATS. With advancing technology and increasingly complex electronic systems, unique ATS has become a problem of maintenance test strategies at the depot; given the high costs of modernizing or replacing ATS and its potential effect on meeting mission success requirements. The aging testers at TYAD are becoming increasingly out-of-date and more difficult to support. When the testers do not work properly, maintenance can suffer and mission readiness can be adversely affected. This will analyze the problem and present a plan for modernization of ATS at TYAD that satisfies Army Regulation, AR750-43, and DoD ATS acquisition policy.
C1 USA, Tobyhanna Army Depot, Test Program, Dev Branch, Tobyhanna, PA USA.
RP Carey, DR (reprint author), USA, Tobyhanna Army Depot, Test Program, Dev Branch, Tobyhanna, PA USA.
NR 3
TC 0
Z9 0
U1 0
U2 1
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-8985
J9 IEEE AERO EL SYS MAG
JI IEEE Aerosp. Electron. Syst. Mag.
PD SEP
PY 2011
VL 26
IS 9
BP 22
EP 26
DI 10.1109/MAES.2011.6069901
PG 5
WC Engineering, Aerospace; Engineering, Electrical & Electronic
SC Engineering
GA 844EA
UT WOS:000296729300004
ER
PT J
AU Wood, RA
Salem, TE
AF Wood, Robert A.
Salem, Thomas E.
TI Evaluation of a 1200-V, 800-A All-SiC Dual Module
SO IEEE TRANSACTIONS ON POWER ELECTRONICS
LA English
DT Article
DE Electric vehicles; high power; inverter; MOSFET; silicon carbide (SiC)
ID MOSFETS
AB Enhanced material properties of silicon carbide (SiC) offer improved performance capabilities for power electronic devices compared to traditional silicon (Si) components. This paper reports on the experimental characterization of a 1200-V, 800-A all-SiC dual power module that incorporates twenty 80-A SiC MOSFETs and twenty 50-A SiC junction barrier Schottky diodes. Forward and reverse conduction characteristics were measured at multiple gate voltages, current sharing was examined between theMOSFETs, and switching energies were calculated for various currents. Additionally, this module has operated in a full-bridge circuit with a peak loading of 900 A(dc), a 600 Vdc bus, and a junction temperatures of 153 degrees C. From the experimental data, a model of the module was created and used in a dc-ac inverter simulation study to demonstrate the possible benefits of SiC compared to Si technology. The use of an all-SiC module was shown to reduce inverter losses by 40% or more for most operating conditions. Furthermore, for similar output current levels, the all-SiC module can operate at switching frequencies four times higher than that of the Si module. This advanced dual power module demonstrates the ability to produce a high-current high-power switch using SiC technology.
C1 [Wood, Robert A.] USA, Res Lab, Adelphi, MD 20783 USA.
[Salem, Thomas E.] USN Acad, Annapolis, MD 21402 USA.
RP Wood, RA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM rawood@arl.army.mil; salem@usna.edu
NR 15
TC 49
Z9 50
U1 0
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-8993
J9 IEEE T POWER ELECTR
JI IEEE Trans. Power Electron.
PD SEP
PY 2011
VL 26
IS 9
BP 2504
EP 2511
DI 10.1109/TPEL.2011.2108670
PG 8
WC Engineering, Electrical & Electronic
SC Engineering
GA 847OA
UT WOS:000296981000014
ER
PT J
AU Bower, KS
Sia, RK
Ryan, DS
Mines, MJ
Stutzman, RD
Kuzmowych, CP
Eaddy, JB
Coe, CD
Wroblewski, KJ
AF Bower, Kraig S.
Sia, Rose K.
Ryan, Denise S.
Mines, Michael J.
Stutzman, Richard D.
Kuzmowych, Chrystyna P.
Eaddy, Jennifer B.
Coe, Charles D.
Wroblewski, Keith J.
TI Visual and IOP Outcomes After PRK in Pigment Dispersion Syndrome
SO JOURNAL OF REFRACTIVE SURGERY
LA English
DT Article
ID PHOTOREFRACTIVE KERATECTOMY; OCULAR HYPERTENSION; REFRACTIVE SURGERY;
CORNEAL THICKNESS; GLAUCOMA
AB PURPOSE: To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome.
METHODS: The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications.
RESULTS: Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5 +/- 6.9 years were included for review. At final follow-up, mean 404.1 +/- 119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7 +/- 3.8 mmHg) at 1 month (18.1 +/- 4.9 mmHg, P=.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35 +/- 0.12) to final postoperative (0.35 +/- 0.13, P=.99).
CONCLUSIONS: Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative. [J Refract Surg. 2011;27(9):686-690.] doi:10.3928/1081597X-20110324-01
C1 [Bower, Kraig S.] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA.
[Sia, Rose K.; Ryan, Denise S.; Mines, Michael J.; Stutzman, Richard D.; Kuzmowych, Chrystyna P.; Eaddy, Jennifer B.; Coe, Charles D.; Wroblewski, Keith J.] Walter Reed Army Med Ctr, Ctr Refract Surg, Washington, DC 20307 USA.
RP Bower, KS (reprint author), Wilmer Eye Inst, Green Spring Stn, Pavil 2,Ste 455,10793 Falls Rd, Lutherville Timonium, MD 21093 USA.
EM kbower5@jhmi.edu
NR 16
TC 0
Z9 0
U1 0
U2 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1081-597X
J9 J REFRACT SURG
JI J. Refractive Surg.
PD SEP
PY 2011
VL 27
IS 9
BP 685
EP 689
DI 10.3928/1081597X-20110324-01
PG 5
WC Ophthalmology; Surgery
SC Ophthalmology; Surgery
GA 846SQ
UT WOS:000296923900011
ER
PT J
AU Perovich, DK
AF Perovich, Donald K.
TI THE CHANGING ARCTIC SEA ICE COVER
SO OCEANOGRAPHY
LA English
DT Article
ID CLIMATE-CHANGE; VARIABILITY; ALBEDO; FEEDBACK; SUMMER
AB Arctic sea ice cover has declined over the past few decades. The end of summer September ice extent reached a record minimum in 2007. While there has been a modest recovery since then, the past four years (2007-2010) show the lowest sea ice extent in the 30-year satellite record. Submarine and satellite ice thickness measurements show a factor of two decrease (3 m to 1. 4 m) from 1957-1976 to 2003-2007. There has been a shift from sea ice cover consisting mainly of ice more than a year old to ice less than a year old. These changes have resulted in a less robust ice cover that is more sensitive to dynamic and thermodynamic forcing. Changes in atmospheric pressure fields in recent years have affected the distribution of ice in the Arctic Basin. Increases in advected ocean heat through Bering Strait may serve as a trigger for ice retreat in the Chukchi and Beaufort Seas. More open water has led to enhanced solar heat input and warming of the upper ocean and greater ice melt. While there may not be a tipping point for Arctic sea ice cover, positive feedbacks do contribute to rapid changes. The declining Arctic sea ice cover is affecting human activities.
C1 [Perovich, Donald K.] USA, Cold Reg Res & Engn Lab, Corps Engineers Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
RP Perovich, DK (reprint author), USA, Cold Reg Res & Engn Lab, Corps Engineers Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA.
EM donald.k.perovich@usace.army.mil
NR 55
TC 37
Z9 38
U1 3
U2 46
PU OCEANOGRAPHY SOC
PI ROCKVILLE
PA P.O. BOX 1931, ROCKVILLE, MD USA
SN 1042-8275
J9 OCEANOGRAPHY
JI Oceanography
PD SEP
PY 2011
VL 24
IS 3
SI SI
BP 162
EP 173
PG 12
WC Oceanography
SC Oceanography
GA 826ZS
UT WOS:000295394700023
ER
PT J
AU Richter-Menge, J
AF Richter-Menge, Jackie
TI SIDEBAR vertical bar POLAR-PALOOZA: An International Polar Year
Community Outreach Project
SO OCEANOGRAPHY
LA English
DT Editorial Material
C1 USA, Corps Engn Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
RP Richter-Menge, J (reprint author), USA, Corps Engn Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
EM jacqueline.a.richter-menge@usace.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OCEANOGRAPHY SOC
PI ROCKVILLE
PA P.O. BOX 1931, ROCKVILLE, MD USA
SN 1042-8275
J9 OCEANOGRAPHY
JI Oceanography
PD SEP
PY 2011
VL 24
IS 3
SI SI
BP 249
EP 249
PG 1
WC Oceanography
SC Oceanography
GA 826ZS
UT WOS:000295394700031
ER
PT J
AU Rogers, CJ
AF Rogers, Clifford J.
TI The development of the longbow in late medieval England and
'technological determinism'
SO JOURNAL OF MEDIEVAL HISTORY
LA English
DT Article
DE Longbow; Technological determinism; Military history; Bows; Archery;
Military revolutions
AB Traditional understandings of the development of the medieval English longbow and its role in the fourteenth-century 'infantry revolution' have recently been challenged by historians. This article responds to the revisionists, arguing based on archaeological, iconographic and textual evidence that the proper longbow was a weapon of extraordinary power, and was qualitatively different from - and more effective than - the shorter self-bows that were the norm in England (and western Europe generally) before the fourteenth century. It is further argued that acknowledging the importance of the weapon as a necessary element of any credible explanation of English military successes in the era of the Hundred Years War does not constitute 'technological determinism'. (C) 2011 Elsevier Lid. All rights reserved.
C1 US Mil Acad, West Point, NY 10996 USA.
RP Rogers, CJ (reprint author), US Mil Acad, Thayer Hall, West Point, NY 10996 USA.
EM clifford.rogers@usma.edu
NR 69
TC 1
Z9 1
U1 2
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4181
J9 J MEDIEVAL HIST
JI J. Mediev. Hist.
PD SEP
PY 2011
VL 37
IS 3
SI SI
BP 321
EP 341
DI 10.1016/j.jmedhist.2011.06.002
PG 21
WC Medieval & Renaissance Studies
SC Arts & Humanities - Other Topics
GA 825SP
UT WOS:000295302700008
ER
PT J
AU Winter, L
AF Winter, Lucas
TI Western Sahara: War, Nationalism and Conflict Irresolution
SO MIDDLE EAST POLICY
LA English
DT Book Review
C1 [Winter, Lucas] USA, Foreign Mil Studies Off, Washington, DC 20310 USA.
RP Winter, L (reprint author), USA, Foreign Mil Studies Off, Washington, DC 20310 USA.
NR 1
TC 0
Z9 0
U1 1
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1061-1924
J9 MIDDLE EAST POLICY
JI Middle East Policy
PD FAL
PY 2011
VL 18
IS 3
BP 175
EP 178
PG 4
WC Area Studies; International Relations
SC Area Studies; International Relations
GA 822OB
UT WOS:000295056900018
ER
PT J
AU Foley, DH
Klein, TA
Lee, IY
Kim, MS
Wilkerson, RC
Harrison, G
Rueda, LM
Kim, HC
AF Foley, Desmond H.
Klein, Terry A.
Lee, In-Yong
Kim, Myung-Soon
Wilkerson, Richard C.
Harrison, Genelle
Rueda, Leopoldo M.
Kim, Heung Chul
TI Mosquito Species Composition and Plasmodium vivax Infection Rates on
Baengnyeong-do (Island), Republic of Korea
SO KOREAN JOURNAL OF PARASITOLOGY
LA English
DT Article
DE Anopheles lesteri; Anopheles kleini; Anopheles sinensis; Plasmodium
vivax; malaria; sporozoite; Baengnyeong-do (Island)
ID SEASONAL PREVALENCE; ANOPHELES-BELENRAE; LIGHT TRAPS; MALARIA; HABITATS;
VECTORS
AB Vivax malaria is a significant military and civilian health threat in the north of the Republic of Korea (ROK). The island of Baengnyeong-do is the westernmost point of the ROK and is located close to the southwestern coast of the Democratic People's Republic of Korea (DPRK). Mosquitoes were collected using a black light trap on Baengnyeong-do, and Anopheles spp. were assayed by PCR, to identify the species, and screened for sporozoites of Plasmodium vivax. Of a subsample of 257 mosquitoes, Anopheles lesteri was the most frequently collected (49.8%), followed by Anopheles sinensis (22.6%), Anopheles pullus (18.7%), Anopheles kleini (7.8%), and Anopheles belenrae (1.2%). The overall sporozoite rate was 3.1%, with the highest rates observed in An. kleini (15.0%), An. sinensis (5.2%), and An. lesteri (1.6%). No sporozoite positive An. pullus or An. belenrae were observed. The results extend our knowledge of the distribution and potential role in malaria transmission of An. kleini, An. lesteri, and An. sinensis, for an area previously considered to be at a low risk for contracting vivax malaria.
C1 [Kim, Heung Chul] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA.
[Foley, Desmond H.; Wilkerson, Richard C.; Harrison, Genelle; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA.
[Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120752, South Korea.
RP Kim, HC (reprint author), 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA.
EM hungchol.kim@amedd.army.mil
RI Valle, Ruben/A-7512-2013;
OI Foley, Desmond/0000-0001-7525-4601
FU Armed Forces Health Surveillance Center, Division of Global Emerging
Infections Surveillance and Response System, Silver Spring, MD, USA;
National Center for Medical Intelligence, Fort Detrick, MD, USA
FX Funding for portions of this work was provided by the Armed Forces
Health Surveillance Center, Division of Global Emerging Infections
Surveillance and Response System, Silver Spring, MD, USA and the
National Center for Medical Intelligence, Fort Detrick, MD, USA. This
research was performed under a Memorandum of Understanding between the
Walter Reed Army Institute of Research and the Smithsonian Institution,
with institutional support provided by both organizations. The opinions
and assertions contained herein are those of the authors and are not to
be construed as official or reflecting the views of the Department of
the Army or the Department of Defense.
NR 22
TC 6
Z9 6
U1 0
U2 1
PU KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
PI SEOUL
PA DEPT PARASITOLOGY, SEOUL, 00000, SOUTH KOREA
SN 0023-4001
EI 1738-0006
J9 KOREAN J PARASITOL
JI Korean J. Parasitol.
PD SEP
PY 2011
VL 49
IS 3
BP 313
EP 316
DI 10.3347/kjp.2011.49.3.313
PG 4
WC Parasitology
SC Parasitology
GA 837CJ
UT WOS:000296168400018
PM 22072836
ER
PT J
AU Segrest, S
AF Segrest, Scott
TI Free Will as an Open Scientific Problem
SO REVIEW OF METAPHYSICS
LA English
DT Book Review
C1 [Segrest, Scott] US Mil Acad, West Point, NY 10996 USA.
RP Segrest, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU CATHOLIC UNIV AMER PRESS
PI WASHINGTON
PA 620 MICHIGAN AVENUE NE ADMIN BLDG ROOM 303, WASHINGTON, DC 20064 USA
SN 0034-6632
J9 REV METAPHYS
JI Rev. Metaphys.
PD SEP
PY 2011
VL 65
IS 1
BP 139
EP 141
PG 3
WC Philosophy
SC Philosophy
GA 831PT
UT WOS:000295744300006
ER
PT J
AU Nordstrom, KF
Jackson, NL
Kraus, NC
Kana, TW
Bearce, R
Bocamazo, LM
Young, DR
De Butts, HA
AF Nordstrom, Karl F.
Jackson, Nancy L.
Kraus, Nicholas C.
Kana, Timothy W.
Bearce, Randy
Bocamazo, Lynn M.
Young, Donald R.
De Butts, Harry A.
TI Enhancing geomorphic and biologic functions and values on backshores and
dunes of developed shores: a review of opportunities and constraints
SO ENVIRONMENTAL CONSERVATION
LA English
DT Review
DE Beach nourishment; coastal erosion; dunes; environmental regulations;
restoration; shore protection
ID OFF-ROAD VEHICLES; SANDY BEACH; SOUTHERN CALIFORNIA; WESTERN-AUSTRALIA;
BARRIER ISLANDS; NEW-JERSEY; NEW-YORK; TRANSPORT; VEGETATION; IMPACTS
AB This article identifies ways to overcome impediments to restoring natural features on developed shores where human-use functions are the dominant driving forces. Suggestions are made for (1) incorporating natural features and natural dynamism into beach nourishment projects; (2) addressing constraints in size and space; (3) reducing the impact of human actions and elements in the landscape; (4) integrating endangered species programmes; (5) overcoming impediments to implementing restoration projects; (6) conducting post-construction evaluations and actions; (7) obtaining public support; and (8) addressing regulatory issues. Beach nourishment projects can better mimic natural landforms, while protecting infrastructure and habitat, creating space for dunes, and providing sediment for dune building. Dunes can have more value as habitat if sub-environments representative of natural gradients are accommodated. Greater human effort will be required to maintain both dynamic and stable zones for habitat, and these zones may be restricted to smaller scales. Controls can be placed on human actions, such as raking the beach, driving on the beach, walking through the dune, emplacing more structures than necessary and introducing exotic vegetation for landscaping. Regulatory restrictions that now prevent environmentally friendly actions can be eased, and adaptive management and education programmes can be implemented.
C1 [Nordstrom, Karl F.] Rutgers State Univ, Inst Marine & Coastal Sci, New Brunswick, NJ 08901 USA.
[Jackson, Nancy L.] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA.
[Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
[Bearce, Randy] New Jersey Dept Environm Protect, Trenton, NJ 08625 USA.
[Bocamazo, Lynn M.] US Army Engineer Dist, New York, NY 10278 USA.
[Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
[De Butts, Harry A.] Borough Avalon, Avalon, NJ 08202 USA.
RP Nordstrom, KF (reprint author), Rutgers State Univ, Inst Marine & Coastal Sci, New Brunswick, NJ 08901 USA.
EM nordstro@marine.rutgers.edu
FU NSF, Research Coordinating Networks (RCN) [DEB-0741928]; New Jersey Sea
Grant; National Oceanic and Atmospheric Administration (NOAA) Office of
Sea Grant; US Department of Commerce under NOAA [NA060AR4170086]; New
Jersey Sea Grant Consortium [NJSG-10-786]
FX This review presents majority views of the collective authors. The
findings and conclusions in this article do not necessarily represent
the views of the authors' employing agencies or organizations. Many of
the ideas in this paper were generated at a workshop held at Avalon, NJ,
USA on 6-7 January 2010. We are grateful to the NSF, Research
Coordinating Networks Program (RCN), DEB-0741928, for providing funding
for the workshop through the Coastal Barrier Island Network (William K.
Smith, principal investigator). This publication is also the result of
research sponsored by New Jersey Sea Grant with funds from the National
Oceanic and Atmospheric Administration (NOAA) Office of Sea Grant, US
Department of Commerce, under NOAA grant number NA060AR4170086 and New
Jersey Sea Grant Consortium. NJSG-10-786. We thank Katherine Korotky and
Brooke Maslo for their help during the workshop. This manuscript
benefitted greatly from comments and advice given by Anne Hecht, US Fish
and Wildlife Service.
NR 83
TC 21
Z9 21
U1 4
U2 41
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0376-8929
J9 ENVIRON CONSERV
JI Environ. Conserv.
PD SEP
PY 2011
VL 38
IS 3
BP 288
EP 302
DI 10.1017/S0376892911000221
PG 15
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 836CQ
UT WOS:000296086500003
ER
PT J
AU Rubal, BJ
McKay, K
Armstrong, KR
AF Rubal, B. J.
McKay, K.
Armstrong, K. R.
TI Intramedullary Pressure Transients during Initial "Flush" of
Intraosseous Cannulas
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Rubal, B. J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[McKay, K.; Armstrong, K. R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 752
EP 752
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000148
ER
PT J
AU Clarkson, ED
Molnar, L
Smith, KH
Kolanko, C
AF Clarkson, E. D.
Molnar, L.
Smith, K. H.
Kolanko, C.
TI Pupillary Light Response in a Guinea Pig Model Exposed to
Organophosphate Agents
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Clarkson, E. D.; Smith, K. H.] USA, Med Inst Chem Def, Aberdeen Proving Ground, MD USA.
[Molnar, L.; Kolanko, C.] Eyemarker Syst, Morgantown, WV USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 795
EP 796
PG 2
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000346
ER
PT J
AU Smith, K
Hall, C
Lydon, H
Dalton, C
Graham, J
Railer, R
Stevenson, R
Deckert, R
Devorak, J
Boecker, J
Braue, E
Lumpkin, H
Doxzon, B
Chilcott, R
Clarkson, ED
AF Smith, K.
Hall, C.
Lydon, H.
Dalton, C.
Graham, J.
Railer, R.
Stevenson, R.
Deckert, R.
Devorak, J.
Boecker, J.
Braue, E.
Lumpkin, H.
Doxzon, B.
Chilcott, R.
Clarkson, E. D.
TI Testing the Ability of Hemostatic Products to Protect against the
Chemical Warfare Agent VX
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Smith, K.; Graham, J.; Railer, R.; Stevenson, R.; Deckert, R.; Devorak, J.; Boecker, J.; Braue, E.; Lumpkin, H.; Doxzon, B.; Clarkson, E. D.] USA, Med Inst Chem Def, Aberdeen Proving Ground, MD USA.
[Hall, C.; Lydon, H.; Dalton, C.; Chilcott, R.] Hlth Protect Agcy, CBRN, Salisbury, Wilts, England.
[Hall, C.; Lydon, H.; Dalton, C.; Chilcott, R.] Hlth Protect Agcy, Chem Toxicol Grp, Salisbury, Wilts, England.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 801
EP 801
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000371
ER
PT J
AU Malone, MM
Szeto, J
Hall, BR
Yoshikawa, T
Troung, JK
Crosby, NM
Osier, M
Lalayeva, N
Beck, TW
Nagata, R
Makori, N
AF Malone, M. M.
Szeto, J.
Hall, B. R.
Yoshikawa, T.
Troung, J. K.
Crosby, N. M.
Osier, M.
Lalayeva, N.
Beck, T. W.
Nagata, R.
Makori, N.
TI An Evaluation of Learning and Memory Based on Hand Dominance in Infant
Nonhuman Primates Using the Wisconsin General Testing Apparatus
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Malone, M. M.; Szeto, J.; Hall, B. R.; Yoshikawa, T.; Troung, J. K.; Crosby, N. M.; Osier, M.; Lalayeva, N.; Beck, T. W.; Nagata, R.; Makori, N.] USA, Sci Serv, SNBL, Everett, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 804
EP 804
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000383
ER
PT J
AU Schulz, SM
Smith, K
Railer, R
Koplovitz, I
Clarkson, ED
AF Schulz, S. M.
Smith, K.
Railer, R.
Koplovitz, I.
Clarkson, E. D.
TI Cutaneous Exposure to GD and VX: Timing Pretreatment and Antidotes
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Schulz, S. M.; Smith, K.; Railer, R.; Koplovitz, I.; Clarkson, E. D.] USA, Med Inst Chem Def, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 815
EP 815
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000429
ER
PT J
AU McCown, ME
Monterroso, VH
Grzeszak, B
AF McCown, M. E.
Monterroso, V. H.
Grzeszak, B.
TI Zoonotic and Infectious Disease Surveillance for Ehrlichia canis,
Anaplasma phagocytophilum, Barrelia burgdorferi, and Dirofilaria immitis
in Dogs in Ecuador
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [McCown, M. E.] USA, Vet Corps, Ft Sam Houston, TX USA.
[Monterroso, V. H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Grzeszak, B.] USA, Vet Corps, Ft Bragg, NC USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2011
VL 50
IS 5
BP 817
EP 817
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 835XJ
UT WOS:000296070000438
ER
PT J
AU Brosten, TR
Codd, SL
Maier, RS
Seymour, JD
AF Brosten, Tyler R.
Codd, Sarah L.
Maier, Robert S.
Seymour, Joseph D.
TI Hydrodynamic dispersion in open cell polymer foam
SO PHYSICS OF FLUIDS
LA English
DT Article
DE flow simulation; flow through porous media; hydrodynamics; lattice
Boltzmann methods; molecular dynamics method; nuclear magnetic
resonance; polymer foams; random processes; statistical mechanics
ID POROUS-MEDIA; FIELD-GRADIENT; FLOW-THROUGH; METAL FOAMS;
LATTICE-BOLTZMANN; CATALYST SUPPORTS; PRESSURE-DROP; NMR; TRANSPORT;
DIFFUSION
AB Nuclear magnetic resonance experiments and pore-scale lattice-Boltzmann simulation in conjunction with random-walk particle-tracking are used to probe molecular displacement statistics over a range of time and lengths within several open-cell polymer foams. Short-time molecular displacement dynamics of a flowing liquid within these structures are shown to reveal a well-defined characteristic transport length scale. The non-equilibrium statistical mechanics theory of dispersion is used to interpret the unique displacement dynamics. Scaling of data from experiment, simulation, and the non-equilibrium statistical mechanics model by the transport length scale collapses the dynamics to dimensionless scaling. Asymptotic dispersion dynamics from NMR experiment are presented as function of Peclet number defined using the transport length scale. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3639269]
C1 [Brosten, Tyler R.; Codd, Sarah L.] Montana State Univ, Dept Mech & Ind Engn, Bozeman, MT 59717 USA.
[Maier, Robert S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Seymour, Joseph D.] Montana State Univ, Dept Chem & Biol Engn, Bozeman, MT 59717 USA.
RP Codd, SL (reprint author), Montana State Univ, Dept Mech & Ind Engn, 220 Roberts Hall, Bozeman, MT 59717 USA.
EM scodd@coe.montana.edu
RI Seymour, Joseph/E-8518-2012; Codd, Sarah/F-1639-2013
OI Seymour, Joseph/0000-0003-4264-5416;
NR 52
TC 3
Z9 3
U1 0
U2 13
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 1070-6631
J9 PHYS FLUIDS
JI Phys. Fluids
PD SEP
PY 2011
VL 23
IS 9
AR 093105
DI 10.1063/1.3639269
PG 10
WC Mechanics; Physics, Fluids & Plasmas
SC Mechanics; Physics
GA 829YD
UT WOS:000295621800030
ER
PT J
AU Parashar, TN
Servidio, S
Shay, MA
Breech, B
Matthaeus, WH
AF Parashar, T. N.
Servidio, S.
Shay, M. A.
Breech, B.
Matthaeus, W. H.
TI Effect of driving frequency on excitation of turbulence in a kinetic
plasma
SO PHYSICS OF PLASMAS
LA English
DT Article
ID COLLISIONLESS MAGNETIC RECONNECTION; ALFVEN-WAVE TURBULENCE; SOLAR-WIND;
MHD TURBULENCE; MAGNETOHYDRODYNAMIC TURBULENCE; CORONA; DISSIPATION;
DISCONTINUITIES; NANOFLARES; SYSTEMS
AB The effect of driving frequency on the efficiency of turbulence generation through magnetic forcing is studied using kinetic hybrid simulations with fully kinetic ions and fluid electrons. The efficiency of driving is quantified by examining the energy input into magnetic field as well as the thermal energy for various driving frequencies. The driving is efficient in exciting turbulence and heating the plasma when the time period of the driving is larger than the nonlinear time of the system. For driving at faster time scales, the energy input is weak and the steady state energy is much lower. The heating of the plasma is correlated with intermittent properties of the magnetic field, which are manifested as non-Gaussian statistics. Implications for turbulence in solar corona are discussed. (C) 2011 American Institute of Physics. [doi:10.1063/1.3630926]
C1 [Parashar, T. N.; Shay, M. A.; Matthaeus, W. H.] Univ Delaware, Dept Phys & Astron, Sharp Lab 217, Newark, DE 19716 USA.
[Servidio, S.] Univ Calabria, Dipartimento Fis, I-87036 Cosenza, Italy.
[Breech, B.] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Parashar, TN (reprint author), Univ Delaware, Dept Phys & Astron, Sharp Lab 217, Newark, DE 19716 USA.
RI Shay, Michael/G-5476-2013;
OI Servidio, Sergio/0000-0001-8184-2151
FU NASA [NNX08AI47G]; NSF [ATM 0752135]
FX This work was supported by the NASA Heliophysics Theory Program,
NNX08AI47G and NSF grant ATM 0752135 (SHINE). We would like to thank S.
P. Gary for useful discussions about Bernstein modes and for providing
the linear Vlasov solver code to verify these kinetic modes observed in
our simulations.
NR 33
TC 30
Z9 30
U1 0
U2 2
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 1070-664X
J9 PHYS PLASMAS
JI Phys. Plasmas
PD SEP
PY 2011
VL 18
IS 9
AR 092302
DI 10.1063/1.3630926
PG 5
WC Physics, Fluids & Plasmas
SC Physics
GA 829XY
UT WOS:000295621300020
ER
PT J
AU Boyd, JW
Deters, KA
Brown, RS
Eppard, MB
AF Boyd, James W.
Deters, Katherine A.
Brown, Richard S.
Eppard, M. Brad
TI Efficacy of Single-Suture Incision Closures in Tagged Juvenile Chinook
Salmon Exposed to Simulated Turbine Passage
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID ACOUSTIC TRANSMITTERS; SWIMMING PERFORMANCE; MAXIMUM TAG; SURVIVAL;
DECOMPRESSION; BAROTRAUMA; PHYSIOLOGY; BEHAVIOR; GROWTH; TROUT
AB Reductions in the size of acoustic transmitters implanted in migrating juvenile salmonids have resulted in the use of a shorter incision-one that may warrant only a single suture for closure. However, it is not known whether a single suture will sufficiently hold the incision closed when fish are decompressed and when outward pressure is placed on the surgical site during turbine passage through hydroelectric dams. The objective of this study was to evaluate the effectiveness of single-suture incision closures on five response variables in juvenile Chinook salmon Oncorhynchus tshawytscha that were subjected to simulated turbine passage. An acoustic transmitter (0.43 g in air) and a passive integrated transponder tag (0.10 g in air) were implanted in each fish; the 6-mm incisions were closed with either one suture or two sutures. After exposure to simulated turbine passage, none of the fish exhibited expulsion of transmitters. In addition, the percentage of fish with suture tearing, incision tearing, or mortal injury did not differ between treatments. Expulsion of viscera through the incision was higher among fish that received one suture (12%) than among fish that received two sutures (1%). The higher incidence of visceral expulsion through single-suture incisions warrants concern. Consequently, for cases in which tagged juvenile salmonids may be exposed to turbine passage, we do not recommend the use of one suture to close 6-mm incisions associated with acoustic transmitter implantation.
C1 [Boyd, James W.; Deters, Katherine A.; Brown, Richard S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
[Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97204 USA.
RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA.
EM rich.brown@pnl.gov
FU U.S. Army Corps of Engineers, Portland District
FX Funding was provided by the U.S. Army Corps of Engineers, Portland
District. We especially thank John Stephenson, Brett Pflugrath, Piper
Benjamin, Andrew Gingerich, Ricardo Walker, Kasey Knox, Marybeth Gay,
Andy LeBarge, and Bob Mueller (Pacific Northwest National Laboratory)
for their valuable assistance. We are grateful to John Skalski and Adam
Seaburg (University of Washington) for scientific and statistical
advice. Animal facilities were certified by the Association for
Assessment and Accreditation of Laboratory Animal Care; fish were
handled in accordance with federal guidelines for the care and use of
laboratory animals, and protocols were approved by the Institutional
Animal Care and Use Committee of Battelle-Pacific Northwest Division.
Reference to trade names does not imply endorsement by Battelle, the
Pacific Northwest National Laboratory, or the U.S. Government.
NR 24
TC 3
Z9 3
U1 3
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0002-8487
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD SEP
PY 2011
VL 140
IS 5
BP 1186
EP 1192
DI 10.1080/00028487.2011.616827
PG 7
WC Fisheries
SC Fisheries
GA 836VM
UT WOS:000296143900004
ER
PT J
AU Lester, PB
Hannah, ST
Harms, PD
Vogelgesang, GR
Avolio, BJ
AF Lester, Paul B.
Hannah, Sean T.
Harms, P. D.
Vogelgesang, Gretchen R.
Avolio, Bruce J.
TI Mentoring Impact on Leader Efficacy Development: A Field Experiment
SO ACADEMY OF MANAGEMENT LEARNING & EDUCATION
LA English
DT Article
ID FEEDBACK-SEEKING BEHAVIOR; SELF-EFFICACY; TRANSFORMATIONAL LEADERSHIP;
MANAGERIAL PERFORMANCE; FUTURE-DIRECTIONS; GOAL ORIENTATION;
ORGANIZATIONS; IDENTITY; METAANALYSIS; PERSONALITY
AB While practitioners and scholars tout the importance of mentorship in leader development, few studies have empirically determined whether mentoring actually positively impacts a leader's development, and if so, in what ways. In a longitudinal field experiment, we examined how a targeted mentorship program that unfolded over 6 months enhanced the development of proteges' leader efficacy and performance. Results showed that the targeted mentorship intervention increased proteges' level of leader efficacy more than a comparison intervention that was based on a more eclectic leadership education program delivered in a group setting. Leader efficacy then predicted rated leader performance. Both proteges' preferences for feedback and trust in the mentor served as important moderators in contributing to the development of leader efficacy. Findings from this longitudinal field experiment could be used by educational institutions and other organizations to enhance their mentorship programs in content, focus, and evaluation of impact.
C1 [Lester, Paul B.] USA, Comprehens Soldier Fitness Program, Washington, DC 20310 USA.
[Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Ethic, West Point, NY USA.
[Harms, P. D.] Univ Nebraska, Lincoln, NE USA.
[Vogelgesang, Gretchen R.] Fed Management Partners Washington, Washington, DC USA.
[Avolio, Bruce J.] Univ Washington, Ctr Leadership & Strateg Thinking, Foster Sch Business, Seattle, WA 98195 USA.
RP Lester, PB (reprint author), USA, Comprehens Soldier Fitness Program, Washington, DC 20310 USA.
EM paul.lester@us.army.mil
NR 99
TC 18
Z9 18
U1 19
U2 53
PU ACAD MANAGEMENT
PI BRIARCLIFF MANOR
PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA
SN 1537-260X
J9 ACAD MANAG LEARN EDU
JI Acad. Manag. Learn. Educ.
PD SEP
PY 2011
VL 10
IS 3
SI SI
BP 409
EP 429
DI 10.5465/amle.2010.0047
PG 21
WC Education & Educational Research; Management
SC Education & Educational Research; Business & Economics
GA 831MK
UT WOS:000295734900004
ER
PT J
AU Buller, M
Cuddihy, P
Davis, E
Doherty, P
Doshi-Velez, F
Erdem, E
Fisher, D
Green, N
Hinkelmann, K
McLurkin, J
Maher, ML
Maheswaran, R
Rubinelli, S
Schurr, N
Scott, D
Shell, D
Szekely, P
Thonssen, B
Urken, AB
AF Buller, Mark
Cuddihy, Paul
Davis, Ernest
Doherty, Patrick
Doshi-Velez, Finale
Erdem, Esra
Fisher, Douglas
Green, Nancy
Hinkelmann, Knut
McLurkin, James
Maher, Mary Lou
Maheswaran, Rajiv
Rubinelli, Sara
Schurr, Nathan
Scott, Donia
Shell, Dylan
Szekely, Pedro
Thoenssen, Barbara
Urken, Arnold B.
TI Reports of the AAAI 2011 Spring Symposia
SO AI MAGAZINE
LA English
DT Article
AB The Association for the Advancement of Artificial Intelligence presented the 2011 Spring Symposium Series Monday through Wednesday, March 21-23, 2011, at Stanford University. This report summarizes the eight symposia.
C1 [Buller, Mark] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Cuddihy, Paul] Gen Elect Res, Niskayuna, NY USA.
[Davis, Ernest] NYU, Courant Inst Math Sci, Dept Comp Sci, New York, NY 10003 USA.
[Doherty, Patrick] Linkoping Univ, Dept Comp & Informat Sci IDA, S-58183 Linkoping, Sweden.
[Doshi-Velez, Finale] MIT, Cambridge, MA 02139 USA.
[Erdem, Esra] Sabanci Univ, Dept Comp Sci & Engn, Istanbul, Turkey.
[Fisher, Douglas] Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN USA.
[Green, Nancy] Univ N Carolina Greensboro, Dept Comp Sci, Greensboro, NC USA.
[McLurkin, James] Rice Univ, Dept Comp Sci, Houston, TX 77251 USA.
[Maher, Mary Lou] Univ Maryland, Human Comp Interact Lab, College Pk, MD 20742 USA.
[Maheswaran, Rajiv; Szekely, Pedro] Univ So Calif, Dept Comp Sci, Los Angeles, CA 90089 USA.
[Scott, Donia] Univ Sussex, Dept Informat, Brighton BN1 9RH, E Sussex, England.
[Shell, Dylan] Texas A&M Univ, Dept Comp Sci & Engn, College Stn, TX 77843 USA.
[Urken, Arnold B.] Univ Arizona, Coll Engn, Tucson, AZ 85721 USA.
RP Buller, M (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA.
RI Erdem, Esra/I-4587-2012
OI Erdem, Esra/0000-0001-8384-7810
NR 0
TC 0
Z9 0
U1 0
U2 6
PU AMER ASSOC ARTIFICIAL INTELL
PI MENLO PK
PA 445 BURGESS DRIVE, MENLO PK, CA 94025-3496 USA
SN 0738-4602
J9 AI MAG
JI AI Mag.
PD FAL
PY 2011
VL 32
IS 3
BP 119
EP 127
PG 9
WC Computer Science, Artificial Intelligence
SC Computer Science
GA 833DQ
UT WOS:000295862400012
ER
PT J
AU Leaungwutiwong, P
Ittiprasert, W
Saikhun, K
Tong-ngam, P
Akapirat, S
Chattanadee, S
Kitiyanant, Y
AF Leaungwutiwong, Pornsawan
Ittiprasert, Wannaporn
Saikhun, Kulnasan
Tong-ngam, Pirut
Akapirat, Siriwat
Chattanadee, Siriporn
Kitiyanant, Yindee
TI Impairment of CD4+CD25+ regulatory T cells in C4-deficient mice
SO ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
LA English
DT Article
DE Antinuclear antibody (ANA); C4 deficiency; CD4+CD25+regulatory T cells;
Forkhead box P3 (Foxp3); Systemic lupus erythematosus (SLE);
Transforming growth factor (TGF)-beta
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTINUCLEAR ANTIBODIES; COMPLEMENT C4;
MOUSE LUPUS; DISEASE; PATHOGENESIS; ALPHA; INDIVIDUALS; DEFICIENCY;
INDUCTION
AB Objective: To investigate the association between deficiencies of early components in the classical complement pathway and the development of SLE.
Methods: Forty inbred C57BL/6J mice and 40 knockout C4 complement gene (C4K0) mice, which included 10 mice in each age group (2, 4, 6, and 8 months) were used. The enumeration of CD4+CD25+ Tregs frequencies in bone marrow, spleen and peripheral blood from both normal and C4K0 groups were performed by flow cytometry. The expression levels of Foxp3 and TGF-beta in the same tested tissues were measured using real time PCR. The antinuclear antibodies (ANA) were semi-quantitatively measured using ELISA.
Results: We report decreased frequencies of CD4+CD25+ Tregs and reduced expression levels of Foxp3 and TGF-beta, which efficiently program the development and function of Tregs, in lymphoid tissues and peripheral blood of C4K0 mice. In this study, C4K0 mice have higher titers of ANA than those of normal mice. Higher frequencies of mice positive for ANA are also found in older mice.
Conclusions: The deficiency of the C4 gene induces the decreased numbers of Tregs that further increase the production of ANA resulting in the development of an autoimmune disorder. The outcomes of our study help us to understand the association between the deficiency of C4 in the classical complement pathway and development of autoimmune disorder via the role of Tregs. (Asian Pac J Allergy Immunol 2011;29:220-8)
C1 [Saikhun, Kulnasan; Tong-ngam, Pirut; Kitiyanant, Yindee] Mahidol Univ, Inst Mol Biosci, Nakhon Pathom 73170, Thailand.
[Leaungwutiwong, Pornsawan; Akapirat, Siriwat; Chattanadee, Siriporn] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok 10400, Thailand.
[Ittiprasert, Wannaporn] Biomed Res Inst, Rockville, MD 20852 USA.
[Akapirat, Siriwat] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand.
[Kitiyanant, Yindee] Mahidol Univ, Fac Sci, Dept Anat, Bangkok 10400, Thailand.
RP Kitiyanant, Y (reprint author), Mahidol Univ, Inst Mol Biosci, Nakhon Pathom 73170, Thailand.
EM scykt@mahidol.ac.th
FU Thailand Research Fund (TRF); Commission of Higher Education (CHE),
Mahidol [02011854-0005, 02011868-0004]; Faculty of Tropical Medicine,
Mahidol University, Thailand
FX This study was financially supported by the Thailand Research Fund
(TRF), Commission of Higher Education (CHE), Mahidol grant numbers
02011854-0005 and 02011868-0004, and Faculty of Tropical Medicine,
Mahidol University, Thailand. We appreciate Mr.Littirong Unjana and
students of the Reproductive and Stem Cell Biology Research group,
Institute of Molecular Biosciences, Mahidol University, Thailand, who
provided technical assistance. We are also grateful for the statistical
advice provided by Ms. Pannamas Maneekarn and Mr. Irwin F. Chavez from
the Department of Tropical Hygiene, Faculty of Tropical Medicine,
Mahidol University, Thailand. Finally, we wish to express our gratitude
to Dr. Mark S. de Souza from the Department of Retrovirology, Armed
Forces Research Institute of Medical Sciences (AFRIMS) for editing the
manuscript.
NR 37
TC 1
Z9 1
U1 0
U2 1
PU ALLERGY IMMUNOL SOC THAILAND,
PI BANGKOK
PA MAHIDOL UNIV, DEPT MICROBIOL IMMUNOL, FACULTY TROPICAL MED, BANGKOK
10400, THAILAND
SN 0125-877X
J9 ASIAN PAC J ALLERGY
JI Asian Pac. J. Allergy Immunol.
PD SEP
PY 2011
VL 29
IS 3
BP 220
EP 228
PG 9
WC Allergy; Immunology
SC Allergy; Immunology
GA 834WF
UT WOS:000295994500003
PM 22053591
ER
PT J
AU Enslen, J
AF Enslen, Joshua
TI Vinicius de Moraes and "Patria minha": The Politics of Writing in
Post-war Brazil
SO HISPANIA-A JOURNAL DEVOTED TO THE TEACHING OF SPANISH AND PORTUGUESE
LA English
DT Article
DE Brazilian poetry; national identity; politics and literature; Post-war
Latin America; Vinicius de Moraes
AB This article analyzes Vinicius de Moraes's "Patria minha" (1948) within the historical context of his first diplomatic post abroad. "Patria minha" was written while Moraes was stationed in Los Angeles as a Consul de Segunda Classe (Ministerio, "Moraes" 385). Moraes's poetic interpretations of Brazil often originated from the standpoint of the relationship between the sexes. "Patria minha" is no exception to this rule, since symbolically gendered relationships play an important role in the poem. Written as an open letter to Brazil of the late 1940s and conceived within the specific politico-cultural context of post-war Latin America, "Patria minha" traces through intimate imagery the contours of Brazilian identity as it conjures a complex and vulnerable nation. In the poem, the nation is articulated as being in transition and threatening dissolution because of its precarious position between local and global hegemonic discourses, namely the Vargas legacy and US expansionism. This article analyzes some of the analogies between Moraes's diplomatic work and his poetic conception of Brazilian identity during this tense period in national history by utilizing original archival materials, such as personal correspondence and diplomatic documents located in the Fundacao Casa de Rui Barbosa and in the Arquivo Historico do Itamaraty in Rio de Janeiro.
C1 US Mil Acad, West Point, NY 10996 USA.
RP Enslen, J (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 29
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC TEACHERS SPANISH PORTUGUESE, INC
PI WALLED LAKE
PA 900 LADD RD, WALLED LAKE, MI 48390 USA
SN 0018-2133
EI 2153-6414
J9 HISPANIA-J DEV INTER
JI Hispania-J. Devoted Teach. Span. Port.
PD SEP
PY 2011
VL 94
IS 3
BP 416
EP 428
PG 13
WC Linguistics; Language & Linguistics; Literature, Romance
SC Linguistics; Literature
GA 829DH
UT WOS:000295555800005
ER
PT J
AU Liu, PW
Lee, H
Judge, J
Wright, WC
Slatton, KC
AF Liu, Pang-Wei
Lee, Heezin
Judge, Jasmeet
Wright, William C.
Slatton, K. Clint
TI Prediction of L-band signal attenuation in forests using 3D vegetation
structure from airborne LiDAR
SO ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
LA English
DT Article
DE Airborne LiDAR; Microwave attenuation; Remote sensing; GPS; 3D
vegetation structure
ID INDIVIDUAL TREE CROWNS; LARGE-FOOTPRINT LIDAR; LASER-SCANNING DATA;
CANOPY STRUCTURE; RAIN-FOREST; AREA DENSITY; WAVE; MODEL; SEGMENTATION;
BIOMASS
AB In this study, we propose a novel method to predict microwave attenuation in forested areas by using airborne Light Detection and Ranging (LiDAR). While propagating through a vegetative medium, microwave signals suffer from reflection, absorption, and scattering within vegetation, which cause signal attenuation and, consequently, deteriorate signal reception and information interpretation. A Fresnel zone enveloping the radio frequency line-of-sight is applied to segment vegetation structure occluding signal propagation. Return parameters and the spatial distribution of vegetation from the airborne LiDAR inside Fresnel zones are used to weight the laser points to estimate directional vegetation structure. A Directional Vegetation Density (DVD) model is developed through regression that links the vegetation structure to the signal attenuation at the L-band using GPS observations in a mixed forest in North Central Florida. The DVD model is compared with currently-used empirical models and obtained better R(2) values of 0.54 than the slab-based models. Finally, the model is evaluated by comparing with GPS observations of signal attenuation. An overall root mean square error of 3.51 dB and a maximum absolute error of 9.38 dB are found. Sophisticated classification algorithms and full-waveform LiDAR systems may significantly improve the estimation of signal attenuation. (C) 2011 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved.
C1 [Liu, Pang-Wei; Judge, Jasmeet] Univ Florida, Ctr Remote Sensing, Agr & Biol Engn Dept, Gainesville, FL 32611 USA.
[Lee, Heezin; Slatton, K. Clint] Univ Florida, Elect & Comp Engn Dept, Gainesville, FL 32611 USA.
[Wright, William C.] US Mil Acad, West Point, NY 10996 USA.
[Slatton, K. Clint] Univ Florida, Civil & Coastal Engn Dept, Gainesville, FL 32611 USA.
RP Liu, PW (reprint author), Univ Florida, Ctr Remote Sensing, Agr & Biol Engn Dept, 280 Roger Hall, Gainesville, FL 32611 USA.
EM bonwei@ufl.edu; fields@ecel.ufl.edu
RI Beckley, Matthew/D-4547-2013
FU National Science Foundation (NSF) through the National Center for
Airborne Laser Mapping (NCALM) [EAR-0518962]; US Army Research Office
(ARO) [W911NF-06-1-0459]
FX This work was partially supported by the National Science Foundation
(NSF) through the National Center for Airborne Laser Mapping (NCALM)
under Grant EAR-0518962 and the US Army Research Office (ARO) under
Grant W911NF-06-1-0459. The authors thank the anonymous reviewers for
their helpful comments and suggestions.
NR 41
TC 2
Z9 2
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-2716
J9 ISPRS J PHOTOGRAMM
JI ISPRS-J. Photogramm. Remote Sens.
PD SEP
PY 2011
VL 66
IS 5
BP 642
EP 651
DI 10.1016/j.isprsjprs.2011.04.005
PG 10
WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing;
Imaging Science & Photographic Technology
SC Physical Geography; Geology; Remote Sensing; Imaging Science &
Photographic Technology
GA 830JM
UT WOS:000295653300009
ER
PT J
AU Lauer, C
Zickgraf, TL
Weisse, ME
AF Lauer, Cynthia
Zickgraf, Thomas L.
Weisse, Martin E.
TI Case Report of Probable Desert Black Snake Envenomation in 22-Year-Old
Male Causing Profound Weakness and Respiratory Distress
SO WILDERNESS & ENVIRONMENTAL MEDICINE
LA English
DT Article
DE neurotoxic; venom; Walterinnesia morgani; respiratory distress; Desert
Black Snake; Elapidae
ID AEGYPTIA; EAST
AB We describe a case of a 22-year-old male who presented to our facility I hour after a snake bite, which he identified as the desert black snake. He presented with severe weakness and respiratory distress. He was treated with polyvalent antivenom and observed in the Intensive Care Unit (ICU) with resolution of his respiratory symptoms. He developed paresthesias locally around his wound and later complained of diplopia. Two days later, he had total resolution of his symptoms. This is one of the only clinical reports of neurotoxic effects after Walterinnesia morgani envenomation.
C1 [Lauer, Cynthia] Martin Army Community Hosp, Dept Surg, Columbus, GA 31906 USA.
[Zickgraf, Thomas L.] Eisenhower Army Med Ctr, Dept Emergency Med, Augusta, GA USA.
[Weisse, Martin E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
RP Lauer, C (reprint author), Martin Army Community Hosp, Dept Surg, 1538 Wells Dr, Columbus, GA 31906 USA.
EM cynthia.lauer@us.army.mil
NR 12
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1080-6032
J9 WILD ENVIRON MED
JI Wildern. Environ. Med.
PD FAL
PY 2011
VL 22
IS 3
BP 246
EP 249
PG 4
WC Public, Environmental & Occupational Health; Sport Sciences
SC Public, Environmental & Occupational Health; Sport Sciences
GA 831RP
UT WOS:000295749100008
PM 21962051
ER
PT J
AU Bakker, M
Farthing, MW
Kees, CE
Woodward, CS
AF Bakker, Mark
Farthing, Matthew W.
Kees, Christopher E.
Woodward, Carol S.
TI Computational challenges in the solution of water resources problems
SO ADVANCES IN WATER RESOURCES
LA English
DT Editorial Material
C1 [Bakker, Mark] Delft Univ Technol, Water Resources Sect, Fac Civil Engn & Geosci, NL-2628 CN Delft, Netherlands.
[Farthing, Matthew W.; Kees, Christopher E.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Woodward, Carol S.] Lawrence Livermore Natl Lab, Ctr Appl Sci Comp, Livermore, CA 94551 USA.
RP Bakker, M (reprint author), Delft Univ Technol, Water Resources Sect, Fac Civil Engn & Geosci, NL-2628 CN Delft, Netherlands.
EM mark.bakker@tudelft.nl; matthew.w.farthing@usace.army.mil;
chris.kees@us.army.mil; cswoodward@llnl.gov
RI Woodward, Carol/M-4008-2014;
OI Bakker, Mark/0000-0002-5629-2861
NR 16
TC 1
Z9 1
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0309-1708
J9 ADV WATER RESOUR
JI Adv. Water Resour.
PD SEP
PY 2011
VL 34
IS 9
SI SI
BP 1059
EP 1061
DI 10.1016/j.advwatres.2011.08.003
PG 3
WC Water Resources
SC Water Resources
GA 830JQ
UT WOS:000295653700001
ER
PT J
AU Man, YG
Fu, SW
Liu, AJ
Stojadinovic, A
Izadjoo, MJ
Chen, L
Gardner, WA
AF Man, Y. G.
Fu, S. W.
Liu, A. J.
Stojadinovic, A.
Izadjoo, M. J.
Chen, L.
Gardner, W. A.
TI Aberrant Expression of Chromogranin A, miR-146a, and miR-146b-5p in
Prostate Structures with Focally Disrupted Basal Cell Layers: An Early
Sign of Invasion and Hormone-refractory Cancer?
SO CANCER GENOMICS & PROTEOMICS
LA English
DT Article
DE Prostate cancer; tumor progression; chromogranin A; basal cells; miRNA
ID INTRAEPITHELIAL NEOPLASIA PIN; ENDOTHELIAL GROWTH-FACTOR; NEUROENDOCRINE
DIFFERENTIATION; MASPIN EXPRESSION; BASEMENT-MEMBRANE; TUMOR INVASION;
DNA PHENOTYPE; PROLIFERATION; CARCINOMA; ANGIOGENESIS
AB Our recent studies have suggested that prostate tumor invasion is triggered by autoimmunoreactions induced focal basal cell layer disruptions (FBCLD) that selectively favor monoclonal proliferation of the overlying progenitors or of a biologically more aggressive cell clone. As circulating chromogranin-A (CgA) levels are found to correlate with tumor progression and the status of hormone refractoriness, our current study attempted to assess whether CgA-positive cells would be preferentially distributed in epithelial structures with FBCLD. Paraffin-embedded specimens from 50 patients with organ-confined prostate cancer were subjected to double immunohistochemical analysis with monoclonal antibodies to basal cells and CgA. From each case, 3-5 randomly selected fields were digitally photographed and the photos were magnified 400% and the numbers of CgA-positive cells in epithelial structures with non-disrupted, focally disrupted, and lost basal cell layer were separately counted. The averaged number of cell for each category was statistically compared with the Pearson's Chi-square test. In addition, morphologically similar structures with and without CgA-positive cell clusters were microdissected from four selected cases and subjected to a comparison of differential micro-RNA expression levels. Our study revealed that, although isolated CgA-positive cells were seen in both the basal cell layer and the luminal cell population in all cases, only 8 cases (16%) harbored large clusters of CgA-positive cells that were concentrated in a given area, in which all or nearly all cells appeared to share a similar morphological and immunohistochemical profile. Microdissected epithelial structures with CgA-positive cell clusters exhibited a more than 5- and 7-fold lower expression of miR-146a and miR-146b-5p than their CgA-negative counterparts. As focal basal cell layer disruptions and the reduction or loss of miR-146a and miR-146b-5p has been documented to correlate with prostate tumor invasion and hormone refractoriness, our findings suggest that aberrant CgA expression in epithelial structures with FBCLD may represent an early sign of these events.
C1 [Man, Y. G.; Izadjoo, M. J.] Henry Jackson Fdn, Diagnost & Translat Res Ctr, Gaithersburg, MD 20879 USA.
[Fu, S. W.; Chen, L.] George Washington Univ, Med Ctr, Dept Med, Div Genom Med, Washington, DC 20037 USA.
[Liu, A. J.] Beijing 301 Hosp, Dept Pathol, Beijing, Peoples R China.
[Stojadinovic, A.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Gardner, W. A.] Armed Forces Inst Pathol, Dept Infect & Parasit Dis Pathol, Amer Registry Pathol, Washington, DC 20306 USA.
RP Man, YG (reprint author), Henry Jackson Fdn, Diagnost & Translat Res Ctr, 401 Profess Dr, Gaithersburg, MD 20879 USA.
EM ymann@hjfresearch.org
FU Congressionally Directed Medical Research Programs [DAMD17-01-1-0129,
DAMD17-01-1-0130, PC051308]; Susan G. Komen Breast Cancer Foundation
[BCTR0706983]; US Military Cancer Institute [2008-02]; Henry M. Jackson
Foundation
FX Supported in part by grants DAMD17-01-1-0129, DAMD17-01-1-0130, PC051308
from Congressionally Directed Medical Research Programs, BCTR0706983
from The Susan G. Komen Breast Cancer Foundation, and 2008-02 from the
US Military Cancer Institute and Henry M. Jackson Foundation to Dr.
Yan-gao Man.
NR 81
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Z9 18
U1 0
U2 2
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
ATHENS 19014, GREECE
SN 1109-6535
J9 CANCER GENOM PROTEOM
JI Cancer Genomics Proteomics
PD SEP-OCT
PY 2011
VL 8
IS 5
BP 235
EP 244
PG 10
WC Oncology; Genetics & Heredity
SC Oncology; Genetics & Heredity
GA 830PF
UT WOS:000295668200003
PM 21980038
ER
PT J
AU Merrick, J
Parnell, GS
AF Merrick, Jason
Parnell, Gregory S.
TI A Comparative Analysis of PRA and Intelligent Adversary Methods for
Counterterrorism Risk Management
SO RISK ANALYSIS
LA English
DT Article
DE Adaptive adversary; risk management; terrorism risk
ID TERRORISM; SECURITY; ATTACKER
AB In counterterrorism risk management decisions, the analyst can choose to represent terrorist decisions as defender uncertainties or as attacker decisions. We perform a comparative analysis of probabilistic risk analysis (PRA) methods including event trees, influence diagrams, Bayesian networks, decision trees, game theory, and combined methods on the same illustrative examples (container screening for radiological materials) to get insights into the significant differences in assumptions and results. A key tenent of PRA and decision analysis is the use of subjective probability to assess the likelihood of possible outcomes. For each technique, we compare the assumptions, probability assessment requirements, risk levels, and potential insights for risk managers. We find that assessing the distribution of potential attacker decisions is a complex judgment task, particularly considering the adaptation of the attacker to defender decisions. Intelligent adversary risk analysis and adversarial risk analysis are extensions of decision analysis and sequential game theory that help to decompose such judgments. These techniques explicitly show the adaptation of the attacker and the resulting shift in risk based on defender decisions.
C1 [Merrick, Jason] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
[Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA.
[Parnell, Gregory S.] Innovat Decis Inc, Vienna, VA USA.
RP Merrick, J (reprint author), POB 843083,1015 Floyd Ave, Richmond, VA 23284 USA.
EM jmerric@vcu.edu
FU U.S. Department of Homeland Security's Domestic Nuclear Detection Office
[2008-DN-077 ARI001-02]; National Science Foundation [CBET-0735735]
FX The authors would like to acknowledge the many discussions and debates
they have had with colleagues that led to the idea for this article. We
would also like to thank the area editor and two knowledgeable reviewers
for their constructive and thoughtful comments. This work was developed
partially under grants from the U.S. Department of Homeland Security's
Domestic Nuclear Detection Office under Grant Award Number 2008-DN-077
ARI001-02 and the National Science Foundation (CBET-0735735). The work
was done at Virginia Commonwealth University and the U.S. Military
Academy at West Point. The views and conclusions contained in this
document are those of the authors and should not be interpreted as
necessarily representing the official policies, either expressed or
implied, of the U.S. Department of Homeland Security, the National
Science Foundation, the U.S. Army, or Innovative Decisions Inc.
NR 23
TC 20
Z9 20
U1 2
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0272-4332
J9 RISK ANAL
JI Risk Anal.
PD SEP
PY 2011
VL 31
IS 9
BP 1488
EP 1510
DI 10.1111/j.1539-6924.2011.01590.x
PG 23
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 826VZ
UT WOS:000295384900012
PM 21418080
ER
PT J
AU Streever, B
Suydam, R
Payne, JF
Shuchman, R
Angliss, RP
Balogh, G
Brown, J
Grunblatt, J
Guyer, S
Kane, DL
Kelley, JJ
Kofinas, G
Lassuy, DR
Loya, W
Martin, P
Moore, SE
Pegau, WS
Rea, C
Reed, DJ
Sformo, T
Sturm, M
Taylor, JJ
Viavant, T
Williams, D
Yokel, D
AF Streever, B.
Suydam, R.
Payne, J. F.
Shuchman, R.
Angliss, R. P.
Balogh, G.
Brown, J.
Grunblatt, J.
Guyer, S.
Kane, D. L.
Kelley, J. J.
Kofinas, G.
Lassuy, D. R.
Loya, W.
Martin, P.
Moore, S. E.
Pegau, W. S.
Rea, C.
Reed, D. J.
Sformo, T.
Sturm, M.
Taylor, J. J.
Viavant, T.
Williams, D.
Yokel, D.
TI Environmental Change and Potential Impacts: Applied Research Priorities
for Alaska's North Slope
SO ARCTIC
LA English
DT Editorial Material
C1 [Streever, B.] BP Explorat Alaska Inc, Anchorage, AK USA.
[Suydam, R.; Sformo, T.] N Slope Borough Dept Wildlife Management, Barrow, AK USA.
[Payne, J. F.; Guyer, S.; Taylor, J. J.] N Slope Sci Initiat, Anchorage, AK USA.
[Shuchman, R.] Michigan Tech Res Inst, Ann Arbor, MI USA.
[Angliss, R. P.; Moore, S. E.] Natl Marine Fisheries Serv, Natl Marine Mammal Lab, Alaska Fisheries Sci Ctr, Seattle, WA USA.
[Balogh, G.] US Fish & Wildlife Serv, Arctic Landscape Conservat Cooperat, Anchorage, AK USA.
[Grunblatt, J.; Kane, D. L.; Kelley, J. J.; Kofinas, G.] Univ Alaska Fairbanks, Fairbanks, AK USA.
[Loya, W.] Wilderness Soc, Anchorage, AK USA.
[Martin, P.] USFWS, Arctic Landscape Conservat Cooperat, Fairbanks, AK USA.
[Pegau, W. S.] Oil Spill Recovery Inst, Cordova, AK USA.
[Rea, C.] Conoco Phillips, Anchorage, AK USA.
[Reed, D. J.] ADFG, Nome, AK USA.
[Sturm, M.] USA CRREL Alaska, Ft Wainwright, AK USA.
[Viavant, T.] ADFG, Fairbanks, AK USA.
[Williams, D.] Bur Ocean Energy Management, Anchorage, AK USA.
[Yokel, D.] Bur Land Management, Arctic Field Off, Fairbanks, AK USA.
RP Streever, B (reprint author), BP Explorat Alaska Inc, Anchorage, AK USA.
EM Bill.Streever@bp.com
NR 14
TC 1
Z9 1
U1 1
U2 14
PU ARCTIC INST N AMER
PI CALGARY
PA UNIV OF CALGARY 2500 UNIVERSITY DRIVE NW 11TH FLOOR LIBRARY TOWER,
CALGARY, ALBERTA T2N 1N4, CANADA
SN 0004-0843
J9 ARCTIC
JI Arctic
PD SEP
PY 2011
VL 64
IS 3
BP 390
EP 397
PG 8
WC Environmental Sciences; Geography, Physical
SC Environmental Sciences & Ecology; Physical Geography
GA 820DZ
UT WOS:000294887000013
ER
PT J
AU Dowding, RJ
AF Dowding, Robert J.
TI HARDMATERIALS: OVERVIEW
SO INTERNATIONAL JOURNAL OF POWDER METALLURGY
LA English
DT Editorial Material
C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Dowding, RJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM robert.j.dowding.civ@mail.mil
RI Dowding, Robert/F-1469-2015
OI Dowding, Robert/0000-0002-4763-2131
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER POWDER METALLURGY INST
PI PRINCETON
PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA
SN 0888-7462
J9 INT J POWDER METALL
JI Int. J. Powder Metall.
PD SEP-OCT
PY 2011
VL 47
IS 5
BP 9
EP 10
PG 2
WC Metallurgy & Metallurgical Engineering
SC Metallurgy & Metallurgical Engineering
GA 828LG
UT WOS:000295501900003
ER
PT J
AU Chanthapan, S
Singh, J
Kulkarni, A
Haines, C
Kapoor, D
AF Chanthapan, Sinthu
Singh, Jogender
Kulkarni, Anil
Haines, Chris
Kapoor, Deepak
TI FIELD-ASSISTED SINTERING OF TUNGSTEN-, TANTALUM-, AND TUNGSTEN
CARBIDE-BASE MATERIALS
SO INTERNATIONAL JOURNAL OF POWDER METALLURGY
LA English
DT Article
ID TOUGHNESS; SYSTEM
AB Sintering of tantalum-, tungsten-, and tungsten carbide (WC)-base materials was investigated utilizing field assisted sintering technology (FAST). The results show that close to pore-free dense sintered products can be obtained at a relatively low temperature without the aid of additives. Limited grain growth was observed in binderless WC but significant grain growth occurred in tantalum and tungsten. WC was beneficial as a sintering additive in tantalum and tungsten; it lowered the sintering temperature, reduced the sintered grain size, and increasing hardness. WC-base materials sintered by FAST exhibited a lower sintering temperature and higher hardness compared with counterpart materials sintered by conventional methods. Bimodal WC-Co materials were also developed by FAST and showed superior mechanical properties.
C1 [Chanthapan, Sinthu; Singh, Jogender; Kulkarni, Anil] Penn State Univ, State Coll, PA 16804 USA.
[Haines, Chris; Kapoor, Deepak] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Chanthapan, S (reprint author), Penn State Univ, State Coll, PA 16804 USA.
EM jxs46@psu.edu
NR 10
TC 0
Z9 0
U1 1
U2 4
PU AMER POWDER METALLURGY INST
PI PRINCETON
PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA
SN 0888-7462
J9 INT J POWDER METALL
JI Int. J. Powder Metall.
PD SEP-OCT
PY 2011
VL 47
IS 5
BP 33
EP 40
PG 8
WC Metallurgy & Metallurgical Engineering
SC Metallurgy & Metallurgical Engineering
GA 828LG
UT WOS:000295501900006
ER
PT J
AU Trexler, M
Carter, R
Helfritch, D
Champagne, V
AF Trexler, Matthew
Carter, Robert
Helfritch, Dennis
Champagne, Victor
TI EFFECT OF CARRIER-GAS SELECTION ON MECHANICAL PROPERTIES OF COLD-SPRAYED
TANTALUM
SO INTERNATIONAL JOURNAL OF POWDER METALLURGY
LA English
DT Article
ID POWDER PARTICLES; COATINGS; VELOCITY; IMPACT
AB Cold spray has been shown to be a viable approach for the consolidation of tantalum powder for structural components that exhibit excellent tensile properties with limited post-processing. It is a novel process used to consolidate metal powders to which ceramic particulates may be added to form both thin coatings and large bulk materials. Cold spray relies on the extensive plastic deformation that occurs when small particles entrained in a supersonic gas stream impact upon a substrate. Carrier-gas selection (nitrogen or helium) can significantly affect the properties of the consolidated materials due to the varying particle velocities that can be achieved. These effects were investigated for tantalum using metallographic techniques, density. measurements, and tensile tests. It is demonstrated that tantalum powder can be consolidated to full density. by cold spraying using helium or nitrogen as the carrier gas. Optimization of the spraying conditions for nitrogen results in consolidated bulk tantalum exhibiting properties comparable with those of tantalum, sprayed with helium, with attendant cost savings.
C1 [Trexler, Matthew; Carter, Robert; Helfritch, Dennis; Champagne, Victor] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Trexler, M (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM matthew.d.trexler.civ@mail.mil
NR 15
TC 0
Z9 0
U1 1
U2 6
PU AMER POWDER METALLURGY INST
PI PRINCETON
PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA
SN 0888-7462
J9 INT J POWDER METALL
JI Int. J. Powder Metall.
PD SEP-OCT
PY 2011
VL 47
IS 5
BP 48
EP 52
PG 5
WC Metallurgy & Metallurgical Engineering
SC Metallurgy & Metallurgical Engineering
GA 828LG
UT WOS:000295501900008
ER
PT J
AU Hayat, AM
Tribble, DR
Sanders, JW
Faix, DJ
Shiau, D
Armstrong, AW
Riddle, MS
AF Hayat, Aatif M.
Tribble, David R.
Sanders, John W.
Faix, Dennis J.
Shiau, Danny
Armstrong, Adam W.
Riddle, Mark S.
TI Knowledge, Attitudes, and Practice of Travelers' Diarrhea Management
among Frontline Providers
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID OPERATIONS IRAQI FREEDOM; ANTIMICROBIAL THERAPY; ENDURING FREEDOM;
EVIDENCE BASE; US MILITARY; EPIDEMIOLOGY; PREVENTION; LOPERAMIDE;
IMPACT; POPULATIONS
AB Background. Many studies have found acute gastrointestinal infections to be among the most likely reason for clinic visits among forward deployed soldiers and are considered a significant contributor to morbidity in this population. This occurs despite the controlled food and water distribution systems under which military populations operate. Furthermore, recent studies have indicated that providers often fail to appropriately identify and treat the typical causes of these infections. To adequately address this issue, an assessment of gaps in knowledge, practice, and management of acute diarrhea in deployed troops was conducted.
Methods. A multiple-choice survey was developed by clinical researchers with expertise in travelers' diarrhea (TD) and provided to a convenience sample of clinical providers with a broad range of training and operational experience. The survey evaluated provider's knowledge of TD along with their ability to identify etiologies of various syndromic categories of acute gastrointestinal infections. Providers were also queried on selection of treatment approaches to a variety of clinical-based scenarios.
Results. A total of 117 respondents completed the survey. Most were aware of the standard definition of TD (77%); however, their knowledge about the epidemiology was lower, with less than 24% correctly answering questions on etiology of diarrhea, and 31% believing that a viral pathogen was the primary cause of watery diarrhea during deployment. Evaluation of scenario-based responses showed that 64% of providers chose not to use antibiotics to treat moderate TD. Furthermore, 19% of providers felt that severe inflammatory diarrhea was best treated with hydration only while 25% felt hydration was the therapy of choice for dysentery. Across all provider types, three practitioner characteristics appeared to be related to better scores on responses to the nine management scenarios: having a Doctor of Medicine or Doctor of Osteopathy degree, greater knowledge of TD epidemiology, and favorable attitudes toward antimotility or antibiotic therapy.
Conclusion. Results from this survey support the need for improving knowledge and management of TD among deploying providers. The information from this study should be considered to support the establishment and dissemination of military diarrhea-management guidelines to assist in improving the health of military personnel.
C1 [Hayat, Aatif M.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Tribble, David R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Sanders, John W.] Naval Med Res Ctr Detachment, Lima, Peru.
[Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA.
[Shiau, Danny] USN, Bur Med & Surg, Washington, DC USA.
[Armstrong, Adam W.] US Naval Med Res Unit 3, Cairo, Egypt.
[Riddle, Mark S.] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA.
RP Riddle, MS (reprint author), USN, Med Res Ctr, Enter Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM mark.riddle@med.navy.mil
RI Riddle, Mark/A-8029-2011
NR 22
TC 4
Z9 4
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD SEP-OCT
PY 2011
VL 18
IS 5
BP 310
EP 317
DI 10.1111/j.1708-8305.2011.00538.x
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 818DI
UT WOS:000294730700004
PM 21896094
ER
PT J
AU Goodchild, SA
Dooley, H
Schoepp, RJ
Flajnik, M
Lonsdale, SG
AF Goodchild, Sarah A.
Dooley, Helen
Schoepp, Randal J.
Flajnik, Martin
Lonsdale, Stephen G.
TI Isolation and characterisation of Ebolavirus-specific recombinant
antibody fragments from murine and shark immune libraries
SO MOLECULAR IMMUNOLOGY
LA English
DT Article
DE Nurse shark; scFv; IgNAR; Ebolavirus; Bio-panning
ID SINGLE-DOMAIN ANTIBODIES; LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER;
PHAGE DISPLAY; REPERTOIRE DEVELOPMENT; MONOCLONAL-ANTIBODIES; VIRUS
NUCLEOPROTEIN; STRUCTURAL-ANALYSIS; MARBURG VIRUSES; NURSE SHARK
AB Members of the genus Ebolavirus cause fulminating outbreaks of disease in human and non-human primate populations with a mortality rate up to 90%. To facilitate rapid detection of these pathogens in clinical and environmental samples, robust reagents capable of providing sensitive and specific detection are required. In this work recombinant antibody libraries were generated from murine (single chain variable domain fragment; scFv) and nurse shark, Ginglymostoma cirratum (IgNAR V) hosts immunised with Zaire ebolavirus. This provides the first recorded IgNAR V response against a particulate antigen in the nurse shark. Both murine scFv and shark IgNAR V libraries were panned by phage display technology to identify useful antibodies for the generation of immunological detection reagents. Two murine scFv were shown to have specificity to the Zaire ebolavirus viral matrix protein VP40. Two isolated IgNAR V were shown to bind to the viral nucleoprotein (NP) and to capture viable Zaire ebolavirus with a high degree of sensitivity. Assays developed with IgNAR V cross-reacted to Reston ebolavirus, Sudan ebolavirus and Bundibugyo ebolavirus. Despite this broad reactivity, neither of IgNAR V showed reactivity to Cote divoire ebolavirus. IgNAR V was substantially more resistant to irreversible thermal denaturation than murine scFv and monoclonal IgG in a comparative test. The demonstrable robustness of the IgNAR V domains may offer enhanced utility as immunological detection reagents in fieldable biosensor applications for use in tropical or subtropical countries where outbreaks of Ebolavirus haemorrhagic fever occur. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
C1 [Goodchild, Sarah A.; Lonsdale, Stephen G.] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England.
[Dooley, Helen; Flajnik, Martin] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Schoepp, Randal J.] USA, Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
RP Goodchild, SA (reprint author), Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England.
EM sagoodchild@mail.dstl.gov.uk
OI Dooley, Helen/0000-0002-2570-574X; Flajnik, Martin
Francis/0000-0002-2792-5084
FU Dstl Innovation Fund; Dstl Programme Office on behalf of the UK Ministry
of Defence
FX The authors gratefully acknowledge the input of Dr. Martin Pearce, Dr.
Carl Mayers and Dr. Clive Sweet for useful discussion and technical
advice within this work, as well as Nicola Walker, Brian Kearney,
Matthew Voorhees, Tamara Clements, Scott Olschner and Aubrey Harbaugh
for valuable assistance. Additionally, the authors gratefully
acknowledge funding for this work by the Dstl Innovation Fund and the
Dstl Programme Office on behalf of the UK Ministry of Defence.
NR 68
TC 24
Z9 25
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0161-5890
J9 MOL IMMUNOL
JI Mol. Immunol.
PD SEP
PY 2011
VL 48
IS 15-16
BP 2027
EP 2037
DI 10.1016/j.molimm.2011.06.437
PG 11
WC Biochemistry & Molecular Biology; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA 826ZY
UT WOS:000295395300035
PM 21752470
ER
PT J
AU Albella, P
Garcia-Cueto, B
Gonzalez, F
Moreno, F
Wu, PC
Kim, TH
Brown, A
Yang, Y
Everitt, HO
Videen, G
AF Albella, Pablo
Garcia-Cueto, Borja
Gonzalez, Francisco
Moreno, Fernando
Wu, Pae C.
Kim, Tong-Ho
Brown, April
Yang, Yang
Everitt, Henry O.
Videen, Gorden
TI Shape Matters: Plasmonic Nanoparticle Shape Enhances Interaction with
Dielectric Substrate
SO NANO LETTERS
LA English
DT Article
DE UV plasmonics; nanoparticles; gallium; shape effects; substrate effects;
nanoantenna
ID DISCRETE-DIPOLE APPROXIMATION; METAL NANOPARTICLES; OPTICAL-PROPERTIES;
RESONANCE SPECTROSCOPY; GALLIUM NANOPARTICLES; SURFACE; SCATTERING;
ENVIRONMENT; PARTICLES
AB Numerical analyses of the ultraviolet and visible plasmonic spectra measured from hemispherical gallium nanostructures on dielectric substrates reveal that resonance frequencies are quite sensitive to illumination angle and polarization in a way that depends on nanostructure size, shape, and substrate. Large, polarization-dependent splittings arise from the broken symmetry of hemispherical gallium nanoparticles on sapphire substrates, inducing strong interactions with the substrate that depend sensitively on the angle of illumination and the nanoparticle diameter.
C1 [Videen, Gorden] USA, Res Lab, RMRD CIE S, Adelphi, MD 20783 USA.
[Albella, Pablo; Garcia-Cueto, Borja; Gonzalez, Francisco; Moreno, Fernando] Univ Cantabria, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain.
[Wu, Pae C.; Kim, Tong-Ho; Brown, April; Everitt, Henry O.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA.
[Yang, Yang; Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
[Everitt, Henry O.] USA, Aviat & Missile RD & E Ctr, RDMR WS, Redstone Arsenal, AL 35898 USA.
RP Videen, G (reprint author), USA, Res Lab, RMRD CIE S, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM gorden.videen@us.army.mil
RI CSIC-UPV/EHU, CFM/F-4867-2012; Everitt, Henry/L-7118-2013;
OI Everitt, Henry/0000-0002-8141-3768; Albella, Pablo/0000-0001-7531-7828
FU USAITC-A [RD 1390-PH-01]; Ministry of Education of Spain
[FIS2007-60158/FIS2010-21984]
FX The authors, especially B.G., would all like to thank USAITC-A for its
funding through project R&D 1390-PH-01. This research was also supported
by the Ministry of Education of Spain under projects
FIS2007-60158/FIS2010-21984. The authors thankfully acknowledge the
computer resources provided by the RES (Red Espanola de
Supercomputacion) node at IFCA (Instituto de Fisica de Cantabria) and
helpful discussions with John V. Foreman.
NR 34
TC 58
Z9 58
U1 0
U2 62
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
J9 NANO LETT
JI Nano Lett.
PD SEP
PY 2011
VL 11
IS 9
BP 3531
EP 3537
DI 10.1021/nl201783v
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 818XO
UT WOS:000294790200004
PM 21848270
ER
PT J
AU Qiu, L
Goossen, KW
Heider, D
O'Brien, DJ
Wetzel, ED
AF Qiu, Liang
Goossen, Keith W.
Heider, Dirk
O'Brien, Daniel J.
Wetzel, Eric D.
TI Free-space input and output coupling to an embedded fiber optic strain
sensor: dual-ended interrogation via transmission
SO OPTICAL ENGINEERING
LA English
DT Article
DE fiber optic sensors; fiber Bragg grating; free-space coupling; embedded
optical fiber egress/ingress; smart structures, composite materials
ID COMPOSITE STRUCTURES; BRAGG GRATINGS; MICROSENSORS; COMPONENTS
AB In this paper, we report a novel method of free-space passive optical coupling to completely embedded, transmission-based fiber Bragg grating (FBG) sensors. Fiber optic sensors (FOS's) have attracted intense research and commercial interest. A major challenge in implementing embedded FOS's, however, is improving upon the cumbersome and fragile ingress/egress techniques commonly used for bringing the sensing light into and out of the structures. In this paper, we successfully couple free-space light into and out of an embedded FBG sensor, without the use of physical connectorization. This coupling is enabled by splicing a multimode fiber (MMF) to a single mode fiber Bragg grating (SMFBG), and using hand polishing to integrate 45 degrees mirrors onto the ingress and egress points of the MMF and SMFBG, respectively. We determine the total loss of the system to be 23 dB, which is considerably better than previous studies that did not use this hand polishing technique. We also demonstrate the application of this free-space coupling technique to strain measurement with a maximum strain of about 2000 mu epsilon. With this approach, no "pigtailing" of optical fibers is needed, and the FBG sensors can be completely embedded inside the structures, greatly increasing system simplicity and robustness. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3625414]
C1 [Qiu, Liang; Goossen, Keith W.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Heider, Dirk] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[O'Brien, Daniel J.; Wetzel, Eric D.] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Qiu, L (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
EM goossen@mail.eecis.udel.edu
FU Army Research Laboratory; [W911NF-06-2-011]
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement No. W911NF-06-2-011. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation heron.
NR 34
TC 4
Z9 4
U1 1
U2 4
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD SEP
PY 2011
VL 50
IS 9
AR 094403
DI 10.1117/1.3625414
PG 14
WC Optics
SC Optics
GA 825FN
UT WOS:000295256700040
ER
PT J
AU Huang, IB
Keisler, J
Linkov, I
AF Huang, Ivy B.
Keisler, Jeffrey
Linkov, Igor
TI Multi-criteria decision analysis in environmental sciences: Ten years of
applications and trends
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Review
DE Multi-criteria decision analysis; Environmental; Risk management;
Decision making; Review; Environmental policy
ID WEIGHTS
AB Decision-making in environmental projects requires consideration of trade-offs between socio-political, environmental, and economic impacts and is often complicated by various stakeholder views. Multi-criteria decision analysis (MCDA) emerged as a formal methodology to face available technical information and stakeholder values to support decisions in many fields and can be especially valuable in environmental decision making. This study reviews environmental applications of MCDA. Over 300 papers published between 2000 and 2009 reporting MCDA applications in the environmental field were identified through a series of queries in the Web of Science database. The papers were classified by their environmental application area, decision or intervention type. In addition, the papers were also classified by the MCDA methods used in the analysis (analytic hierarchy process, multi-attribute utility theory, and outranking). The results suggest that there is a significant growth in environmental applications of MCDA over the last decade across all environmental application areas. Multiple MCDA tools have been successfully used for environmental applications. Even though the use of the specific methods and tools varies in different application areas and geographic regions, our review of a few papers where several methods were used in parallel with the same problem indicates that recommended course of action does not vary significantly with the method applied. Published by Elsevier B.V.
C1 [Linkov, Igor] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Keisler, Jeffrey] Univ Massachusetts, Coll Management, Boston, MA 02125 USA.
[Huang, Ivy B.] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA.
RP Linkov, I (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Igor.Linkov@usace.army.mil
FU U.S. Army Engineer Research and Development Center
FX We would like to thank Ms. Laure Canis for help in classifying the
papers. Mr. Alex Tkachuk, Drs. Mayank Mohan and Todd Bridges provided
helpful discussions and support. This effort was sponsored in part by
the Dredging Operations Environmental Research (DOER) and Civil Works
Basic Research Program by the U.S. Army Engineer Research and
Development Center.
NR 23
TC 197
Z9 204
U1 13
U2 122
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD SEP 1
PY 2011
VL 409
IS 19
BP 3578
EP 3594
DI 10.1016/j.scitotenv.2011.06.022
PG 17
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 824WW
UT WOS:000295233900003
PM 21764422
ER
PT J
AU Cancelas, J
Rugg, N
Pratt, PG
Worsham, DN
Hartman, EL
Dunn, SK
O'Leary, MJ
Ransom, JH
Michael, RA
Macdonald, VW
AF Cancelas, J.
Rugg, N.
Pratt, P. G.
Worsham, D. N.
Hartman, E. L.
Dunn, S. K.
O'Leary, M. J.
Ransom, J. H.
Michael, R. A.
Macdonald, V. W.
TI In Vitro and In Vivo Viability and Function of 2-Day Stored, Irradiated,
Cryopreserved Platelets
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting and CTTXPO
CY OCT 22-25, 2011
CL San Diego, CA
SP AABB
C1 [Cancelas, J.; Rugg, N.; Pratt, P. G.; Worsham, D. N.; Hartman, E. L.; Dunn, S. K.; O'Leary, M. J.] Univ Cincinnati, Hoxworth Blood Ctr, Cincinnati, OH USA.
[Ransom, J. H.] Fast Track Drugs & Biol, Potomac, MD USA.
[Michael, R. A.; Macdonald, V. W.] USA, Ft Detrick, MD USA.
EM jose.cancelas@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2011
VL 51
SU 3
SI SI
BP 61A
EP 62A
PG 2
WC Hematology
SC Hematology
GA 822YC
UT WOS:000295085500149
ER
PT J
AU Pidcoke, HF
Delgado, KK
Mora, AG
Reddy, HL
Goodrich, R
Cap, AP
AF Pidcoke, H. F.
Delgado, K. K.
Mora, A. G.
Reddy, H. L.
Goodrich, R.
Cap, A. P.
TI Pathogen Reduction in Whole Blood with Riboflavin and Ultraviolet Light
Does Not Affect Platelet Count or Function
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting and CTTXPO
CY OCT 22-25, 2011
CL San Diego, CA
SP AABB
C1 [Pidcoke, H. F.; Delgado, K. K.; Mora, A. G.; Cap, A. P.] USA, Inst Surg Res, San Antonio, TX USA.
[Pidcoke, H. F.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Reddy, H. L.; Goodrich, R.] CaridianBCT Biotechnol, Lakewood, TX USA.
EM heather.pidcoke@us.army.mil
NR 0
TC 2
Z9 2
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2011
VL 51
SU 3
SI SI
BP 64A
EP 65A
PG 2
WC Hematology
SC Hematology
GA 822YC
UT WOS:000295085500157
ER
PT J
AU Delgado, KK
Pidcoke, HF
Mora, AG
Cap, AP
AF Delgado, K. K.
Pidcoke, H. F.
Mora, A. G.
Cap, A. P.
TI Platelet Function in Stored Whole Blood Measured by a Shear- and Von
Willebrand Factor-Dependent Methodology is Retained During Storage at 4
degrees C for up to 7 Days
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting and CTTXPO
CY OCT 22-25, 2011
CL San Diego, CA
SP AABB
C1 [Delgado, K. K.; Pidcoke, H. F.; Mora, A. G.; Cap, A. P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Pidcoke, H. F.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
EM krystal.valdez@us.army.mil
NR 0
TC 3
Z9 3
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2011
VL 51
SU 3
SI SI
BP 65A
EP 65A
PG 1
WC Hematology
SC Hematology
GA 822YC
UT WOS:000295085500158
ER
PT J
AU White, E
Gery, LV
Baker, TP
Beardsley, SG
AF White, E.
Gery, L. V.
Baker, T. P.
Beardsley, S. G.
TI Blood Bank Testing Helps Identify Rare Disorder in Undiagnosed Patient
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting and CTTXPO
CY OCT 22-25, 2011
CL San Diego, CA
SP AABB
C1 [White, E.; Gery, L. V.; Baker, T. P.; Beardsley, S. G.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA.
EM erika.white1@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2011
VL 51
SU 3
SI SI
BP 192A
EP 193A
PG 2
WC Hematology
SC Hematology
GA 822YC
UT WOS:000295085500494
ER
PT J
AU Lesho, E
Forestiero, FJ
Hirata, MH
Hirata, RD
Cecon, L
Melo, FF
Paik, SH
Murata, Y
Ferguson, EW
Wang, ZN
Ooi, GT
AF Lesho, Emil
Forestiero, Francisco J.
Hirata, Mario H.
Hirata, Rosario D.
Cecon, Leticia
Melo, Fernando F.
Paik, Sun H.
Murata, Yoko
Ferguson, Earl W.
Wang, Zhining
Ooi, Guck T.
TI Transcriptional responses of host peripheral blood cells to tuberculosis
infection
SO TUBERCULOSIS
LA English
DT Article
DE Tuberculosis; Microarray analysis; Genes; Peripheral blood cells;
Insulin signaling
ID GENE-EXPRESSION PROFILES; ANGELMAN SYNDROME; E6 ONCOPROTEIN; PROTEIN;
MYCOBACTERIA; IMMUNITY; CYTOKINE; SUSCEPTIBILITY; MACROPHAGES;
VACCINATION
AB Host responses following exposure to Mycobacterium tuberculosis (TB) are complex and can significantly affect clinical outcome. These responses, which are largely mediated by complex immune mechanisms involving peripheral blood cells (PBCs) such as T-lymphocytes, NK cells and monocyte-derived macrophages, have not been fully characterized. We hypothesize that different clinical outcome following TB exposure will be uniquely reflected in host gene expression profiles, and expression profiling of PBCs can be used to discriminate between different TB infectious outcomes. In this study, microarray analysis was performed on PBCs from three TB groups (BCG-vaccinated, latent TB infection, and active TB infection) and a control healthy group. Supervised learning algorithms were used to identify signature genomic responses that differentiate among group samples. Gene Set Enrichment Analysis was used to determine sets of genes that were co-regulated. Multivariate permutation analysis (p < 0.01) gave 645 genes differentially expressed among the four groups, with both distinct and common patterns of gene expression observed for each group. A 127-probeset, representing 77 known genes, capable of accurately classifying samples into their respective groups was identified. In addition, 13 insulin-sensitive genes were found to be differentially regulated in all three TB infected groups, underscoring the functional association between insulin signaling pathway and TB infection. Published by Elsevier Ltd.
C1 [Lesho, Emil] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Forestiero, Francisco J.; Hirata, Mario H.; Hirata, Rosario D.; Cecon, Leticia] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo, Brazil.
[Melo, Fernando F.] Clemente Ferreira Inst, Sao Paulo, Brazil.
[Paik, Sun H.; Murata, Yoko; Ferguson, Earl W.; Ooi, Guck T.] Sun BioMed Technol Inc, Ridgecrest, CA 93555 USA.
[Wang, Zhining] NCI, SRA Int Inc, NIH, Bethesda, MD 20892 USA.
RP Lesho, E (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Emil.Lesho@us.army.mil
RI Hirata, Mario/D-3593-2012; Hirata, Rosario/A-7284-2011; Hirata,
Mario/C-9718-2013
FU Center for Disease Control and Prevention (CDC) Small Business
Innovative Research (SBIR) [200-2006-M-19004, 200-2008-27867]
FX This study was funded through the Center for Disease Control and
Prevention (CDC) Small Business Innovative Research (SBIR) grant awards
(Award Number 200-2006-M-19004 & 200-2008-27867) to Sun BioMedical
Technologies, Inc. (SHP, YM, EWF, GTO). Besides funding, CDC does not
participate in the study design, data collection, data analysis and
interpretation, preparation of the manuscript and decision to publish
the work described in this study.
NR 56
TC 35
Z9 35
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1472-9792
J9 TUBERCULOSIS
JI Tuberculosis
PD SEP
PY 2011
VL 91
IS 5
SI SI
BP 390
EP 399
DI 10.1016/j.tube.2011.07.002
PG 10
WC Immunology; Microbiology; Respiratory System
SC Immunology; Microbiology; Respiratory System
GA 827XE
UT WOS:000295462300007
PM 21835698
ER
PT J
AU Wichelecki, DJ
McNew, TM
Aygun, A
Torrey, K
Stephenson, LD
AF Wichelecki, Daniel J.
McNew, Trisha M.
Aygun, Aysegul
Torrey, Kathryn
Stephenson, Larry D.
TI Detection of Liposome Lysis Utilizing an Enzyme-Substrate System
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE beta-Galactosidase; Encapsulation; Liposome; Lysis; ONP; ONPG
ID SILICA NANOPARTICLES; QUANTUM DOTS; MODEL; PHOSPHOLIPIDS; ENCAPSULATION;
FORMULATION; DYES
AB A novel optical reporter system was developed to verify encapsulation and subsequent release of a foreign molecule in liposomes. The protocol utilizes a single enzyme and substrate. We encapsulate o-nitrophenyl-beta,d-galactopyranoside (ONPG) and measure its release by detecting the levels of o-nitrophenol created when the encapsulated ONPG is released and hydrolyzed by beta-galactosidase. Using this method, liposome formation and subsequent lysis with Triton X-100 were verified. This new protocol eliminates the complications of multiple reaction enzyme detection methods, along with the chance for false negatives and unreliable data seen when using fluorescent particles as reporters.
C1 [Aygun, Aysegul; Torrey, Kathryn; Stephenson, Larry D.] USA, CERL, ERDC, Champaign, IL 61822 USA.
[Wichelecki, Daniel J.; McNew, Trisha M.; Torrey, Kathryn] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
RP Stephenson, LD (reprint author), USA, CERL, ERDC, Champaign, IL 61822 USA.
EM Larry.D.Stephenson@usace.army.mil
FU USACE [6.1]
FX This work was all done at ERDC-CERL and was funded by USACE 6.1 funds.
The authors would also like to thank Ms. K. L. Whalen for aid in editing
the paper.
NR 20
TC 1
Z9 1
U1 1
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0273-2289
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD SEP
PY 2011
VL 165
IS 2
BP 548
EP 558
DI 10.1007/s12010-011-9274-3
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 823ZB
UT WOS:000295166400014
PM 21607678
ER
PT J
AU Williams, JB
Orr, SC
AF Williams, Justin B.
Orr, Scott C.
TI AN UNUSUAL PRESENTATION OF A RIGHT OVARIAN DERMOID CYST
SO JOURNAL OF EMERGENCY MEDICINE
LA English
DT Editorial Material
ID TERATOMAS
C1 [Williams, Justin B.] Brooke Army Med Ctr, MCHE EMR, SAUSHEC Emergency Med Residency, Ft Sam Houston, TX 78234 USA.
[Orr, Scott C.] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Emergency Med Residency Program, Ft Sam Houston, TX 78234 USA.
RP Williams, JB (reprint author), Brooke Army Med Ctr, MCHE EMR, SAUSHEC Emergency Med Residency, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 8
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0736-4679
J9 J EMERG MED
JI J. Emerg. Med.
PD SEP
PY 2011
VL 41
IS 3
BP 296
EP 297
DI 10.1016/j.jemermed.2009.04.056
PG 2
WC Emergency Medicine
SC Emergency Medicine
GA 824IX
UT WOS:000295196700012
PM 19481900
ER
PT J
AU Slingerland, EJ
Jahngen, EGE
Goyette, TM
Giles, RH
Nixon, WE
AF Slingerland, Elizabeth J.
Jahngen, Edwin G. E.
Goyette, Thomas M.
Giles, Robert H.
Nixon, William E.
TI Terahertz absorption spectra of nitromethane
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Nitromethane; CH3NO2; Spectroscopy; THz; FTIR
ID INTERNAL-ROTATION; INFRARED-SPECTRA; DYNAMICS; SPECTROSCOPY
AB Nitromethane, with its heavy frame and internal rotator, readily evaporates into the atmosphere making it an ideal candidate for remote sensing. Here we present the absorption spectra of gas-phase nitromethane between 9 and 50 cm(-1). Measurements were taken using a Bruker IFS 66v Fourier transform far-infrared (FTIR) spectrometer at a resolution of 0.12 cm(-1) (0.0036 THz) from 9 to 40 cm(-1) and a Bruker Vertex 80v ETIR spectrometer with a resolution of 0.0075 cm(-1) (0.00226 THz) from 10 to 50 cm(-1). The absorption spectra were measured at multiple pathlengths ranging from 2 to 6 m. These measurements were used to calculate the absorption coefficient of nitromethane as a function of wavenumber. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Slingerland, Elizabeth J.; Goyette, Thomas M.; Giles, Robert H.] Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
[Jahngen, Edwin G. E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA.
[Nixon, William E.] USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA.
RP Slingerland, EJ (reprint author), Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
EM elizabeth_slingerland@student.uml.edu
NR 25
TC 5
Z9 8
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD SEP
PY 2011
VL 112
IS 14
BP 2323
EP 2329
DI 10.1016/j.jqsrt.2011.06.006
PG 7
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 823FW
UT WOS:000295108900008
ER
PT J
AU Alino, J
AF Alino, J.
TI Misleading conclusion from the unifying theory of the stellate ganglion
block for the treatment of posttraumatic stress disorder
SO MEDICAL HYPOTHESES
LA English
DT Letter
C1 Tripler Army Med Ctr, Tripler AMC, Honolulu, HI 96859 USA.
RP Alino, J (reprint author), Tripler Army Med Ctr, Tripler AMC, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM justin.alino@amedd.army.mil
NR 2
TC 1
Z9 1
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2011
VL 77
IS 3
BP 465
EP 465
DI 10.1016/j.mehy.2011.06.038
PG 1
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 824DX
UT WOS:000295183500040
PM 21737206
ER
PT J
AU Prust, M
Wang, J
Morizono, H
Messing, A
Brenner, M
Gordon, E
Hartka, T
Sokohl, A
Schiffmann, R
Gordish-Dressman, H
Albin, R
Amartino, H
Brockman, K
Dinopoulos, A
Dotti, MT
Fain, D
Fernandez, R
Ferreira, J
Fleming, J
Gill, D
Griebel, M
Heilstedt, H
Kaplan, P
Lewis, D
Nakagawa, M
Pedersen, R
Reddy, A
Sawaishi, Y
Schneider, M
Sherr, E
Takiyama, Y
Wakabayashi, K
Gorospe, JR
Vanderver, A
AF Prust, M.
Wang, J.
Morizono, H.
Messing, A.
Brenner, M.
Gordon, E.
Hartka, T.
Sokohl, A.
Schiffmann, R.
Gordish-Dressman, H.
Albin, R.
Amartino, H.
Brockman, K.
Dinopoulos, A.
Dotti, M. T.
Fain, D.
Fernandez, R.
Ferreira, J.
Fleming, J.
Gill, D.
Griebel, M.
Heilstedt, H.
Kaplan, P.
Lewis, D.
Nakagawa, M.
Pedersen, R.
Reddy, A.
Sawaishi, Y.
Schneider, M.
Sherr, E.
Takiyama, Y.
Wakabayashi, K.
Gorospe, J. R.
Vanderver, A.
TI GFAP mutations, age at onset, and clinical subtypes in Alexander disease
SO NEUROLOGY
LA English
DT Article
ID FIBRILLARY ACIDIC PROTEIN; JUVENILE FORM; GENE; PATIENT; SPECTROSCOPY;
DIAGNOSIS; ATAXIA
AB Objective: To characterize Alexander disease (AxD) phenotypes and determine correlations with age at onset (AAO) and genetic mutation. AxD is an astrogliopathy usually characterized on MRI by leukodystrophy and caused by glial fibrillary acidic protein (GFAP) mutations.
Methods: We present 30 new cases of AxD and reviewed 185 previously reported cases. We conducted Wilcoxon rank sum tests to identify variables scaling with AAO, survival analysis to identify predictors of mortality, and chi(2) tests to assess the effects of common GFAP mutations. Finally, we performed latent class analysis (LCA) to statistically define AxD subtypes.
Results: LCA identified 2 classes of AxD. Type I is characterized by early onset, seizures, macrocephaly, motor delay, encephalopathy, failure to thrive, paroxysmal deterioration, and typical MRI features. Type II is characterized by later onset, autonomic dysfunction, ocular movement abnormalities, bulbar symptoms, and atypical MRI features. Survival analysis predicted a nearly 2-fold increase in mortality among patients with type I AxD relative to those with type II. R79 and R239 GFAP mutations were most common (16.6% and 20.3% of all cases, respectively). These common mutations predicted distinct clinical outcomes, with R239 predicting the most aggressive course.
Conclusions: AAO and the GFAP mutation site are important clinical predictors in AxD, with clear correlations to defined patterns of phenotypic expression. We propose revised AxD subtypes, type I and type II, based on analysis of statistically defined patient groups. Neurology (R) 2011; 77: 1287-1294
C1 [Prust, M.; Wang, J.; Hartka, T.; Sokohl, A.; Gordish-Dressman, H.; Vanderver, A.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Messing, A.] Univ Wisconsin, Madison, WI 53706 USA.
[Brenner, M.] Univ Alabama, Birmingham, AL USA.
[Gordon, E.] Coriell Inst Med Res, Camden, NJ USA.
[Schiffmann, R.; Heilstedt, H.] Baylor Res Inst, Waco, TX USA.
[Albin, R.] Univ Michigan, Vet Affairs Ann Arbor Hlth Syst Geriatr Res Educ, Ann Arbor, MI 48109 USA.
[Amartino, H.] Hosp Univ Austral, Pilar, Argentina.
[Brockman, K.] Univ Gottingen, Gottingen, Germany.
[Dinopoulos, A.] Univ Athens, Athens, Greece.
[Dotti, M. T.] Univ Siena, I-53100 Siena, Italy.
[Fain, D.] Bronson Hosp, Kalamazoo, MI USA.
[Fernandez, R.] Univ S Florida, Sch Med, Tampa, FL 33620 USA.
Tauranga Hosp, Tauranga, New Zealand.
[Gill, D.] Childrens Hosp Westmead, Dept Neurol, Sydney, NSW, Australia.
[Griebel, M.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Kaplan, P.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Lewis, D.] Univ Med Ctr, Durham, NC USA.
[Nakagawa, M.] Kyoto Prefectural Univ Med, Kyoto, Japan.
[Pedersen, R.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Reddy, A.] Childrens Hosp Alabama, Birmingham, AL USA.
[Sawaishi, Y.] Akita Prefectural Ctr Dev & Disabil, Akita, Japan.
[Schneider, M.] So Illinois Univ, Sch Med, Springfield, IL USA.
[Sherr, E.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Takiyama, Y.] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Yamanashi, Japan.
[Wakabayashi, K.] Showa Univ, Fujigaoka Hosp, Yokohama, Kanagawa 227, Japan.
[Gorospe, J. R.] NIH, Natl Ctr Res Resources, Bethesda, MD 20892 USA.
RP Vanderver, A (reprint author), Childrens Natl Med Ctr, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM avanderv@cnmc.org
OI Morizono, Hiroki/0000-0002-9678-5564
FU NIH IDDRC [P30HD4067]; NIH NCMRR/NINDS [5R24 HD050846]; Delman Fund;
Children's National Medical Center Neurology Department; NIH; Children's
National Medical Center; Kettering Family Foundation; NIH (NINDS,
NICHD); NIH (NIDDK, NHGRI); Shire plc; Amicus Therapeutics, Inc.; Baylor
Research Foundation; Michael J. Fox Foundation; VA Merit Review program;
Genzyme Corporation; Amicus Therapeutics, Inc; Bundesministerium fur
Bildung und Forschung (BMBF) through the German Leukodystrophy Network;
UCB; Pfizer; King Pharmaceuticals; Sunovion Pharmaceuticals Inc.
(Dainippon Sumitomo Pharma); Lundbeck Inc.; Supernus Pharmaceuticals,
Inc.; Eisai Inc.; NIH/NINDS; Appalachian State University; Ministry of
Health, Labour, and Welfare of the Government of Japan; March of Dimes;
Aicardi Syndrome Foundation; Weston Havens Foundation; Simons
Foundation; American Academy of Neurology Foundation; Dana Foundation
FX Supported in part by NIH IDDRC P30HD4067 (Intellectual and Developmental
Disabilities Core) and NIH NCMRR/NINDS 5R24 HD050846 (Integrated
Molecular Core for Rehabilitation Medicine). M. P. was supported by the
Delman Fund and the Children's National Medical Center Neurology
Department.; M. Prust and Dr. Wang report no disclosures. Dr. Morizono
receives research support from the NIH, the Children's National Medical
Center, and the Kettering Family Foundation. Dr. Messing receives
research support from the NIH. Dr. Brenner receives research support
from the NIH (NINDS, NICHD). E. Gordon serves on scientific advisory
boards for Acceleron Pharma and Chesapeake Research Review Inc.; has
received funding for travel and speaker honoraria from Affymetrix, Inc.;
serves as a consultant for MedIQ; receives research support from the NIH
(NIDDK, NHGRI); and holds stock options in Illumina, Inc.; and her
spouse is employed by Illumina, Inc. Dr. Hartka and A. Sokhol report no
disclosures. Dr. Schiffmann has served on scientific advisory boards for
and received funding for travel and speaker honoraria from Shire plc and
Amicus Therapeutics, Inc.; has a patent pending re: Tetrahydrobiopterin
in Fabry disease; has served as a consultant for Zacharon
Pharmaceuticals; and has received research support from Shire plc,
Amicus Therapeutics, Inc., and the Baylor Research Foundation. H.
Gordish-Dressman receives research support from the NIH (NINDS, NICHD).
Dr. Albin serves on data safety monitoring boards for Medivation, Inc.
and the NIH/NINDS; serves on the editorial boards of Neurology (R),
Experimental Neurology, and Neurobiology of Disease; serves as a
consultant for Best Doctors; receives research support from the NIH and
the Michael J. Fox Foundation; is a staff physician at the Veteran's
Affairs Ann Arbor Health System and receives grant support from the VA
Merit Review program; and has served as an expert witness in
medico-legal cases. Dr. Amartino serves on scientific advisory boards
for Genzyme Corporation and Shire plc and has received funding for
travel or speaker honoraria from Genzyme Corporation, Shire plc, and
Amicus Therapeutics, Inc. Dr. Brockman serves as Co-Editor-in-Chief of
Kinderarztliche Praxis, Kirchheim Verlag, Mainz, Germany (a German
educational journal for pediatricians) and has received research support
from the Bundesministerium fur Bildung und Forschung (BMBF) through the
German Leukodystrophy Network. Dr. Dinopoulos and Dr. Dotti report no
disclosures. Dr. Fain is on the speakers' bureau for and has received
speaker honoraria from UCB. Dr. Fernandez reports no disclosures. Dr.
Ferreira has received research support from Pfizer, King
Pharmaceuticals, UCB, Sunovion Pharmaceuticals Inc. (Dainippon Sumitomo
Pharma), Lundbeck Inc., Supernus Pharmaceuticals, Inc., and Eisai Inc.
Dr. Fleming, Dr. Gill, Dr. Griebel, and Dr. Heilstedt report no
disclosures. Dr. Kaplan has served on scientific advisory boards, as a
consultant, and on the speakers' bureau for and received speaker
honoraria and research support from Genzyme Corporation and serves as an
Associate Editor for the European Journal of Pediatrics. Dr. Lewis
receives research support from the NIH/NINDS and Appalachian State
University. Dr. Nakagawa receives research support from the Ministry of
Health, Labour, and Welfare of the Government of Japan. Dr. Pederson,
Dr. Reddy, Dr. Sawaishi, and Dr. Schneider report no disclosures. Dr.
Sherr receives support for his laboratory from Pfizer Inc; and receives
research support from the NIH/NINDS, the March of Dimes, the Aicardi
Syndrome Foundation, the Weston Havens Foundation, and the Simons
Foundation; holds stock/stock options in Sensorin, Inc., Plexxicon,
Ingenuity Systems, Inc. (spouse is employee), and ChemoCentryx; and has
provided expert counsel in medico- legal cases. Dr. Takiyama, Dr.
Wakabayashi, and Dr.; Grospe report no disclosures. Dr. Vanderver has a
patent pending re: The use of cerebrospinal fluid asialotransferrin in
the diagnosis of vanishing white matter disease and receives/has
received research support from the NIH/NINDS, the American Academy of
Neurology Foundation, and the Dana Foundation.
NR 40
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U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD SEP
PY 2011
VL 77
IS 13
BP 1287
EP 1294
DI 10.1212/WNL.0b013e3182309f72
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 825EM
UT WOS:000295253800018
PM 21917775
ER
PT J
AU Pitisuttithum, P
Rerks-Ngarm, S
Chiu, J
Kim, J
Benenson, M
Kent, SJ
Tamashiro, H
Manrique, A
Bernstein, A
Goyal, R
Ditangco, RA
Cooper, DA
Osmanov, S
Mathieson, B
Sandstrom, E
Esparza, J
Hoff, R
Shao, YM
AF Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Chiu, Joseph
Kim, Jerome
Benenson, Michael
Kent, Stephen J.
Tamashiro, Hiko
Manrique, Amapola
Bernstein, Alan
Goyal, Rajat
Ditangco, Rossana A.
Cooper, David A.
Osmanov, Saladin
Mathieson, Bonnie
Sandstrom, Eric
Esparza, Jose
Hoff, Rodney
Shao, Yiming
CA AIDS Vaccine Asia Network
TI ACCELERATING THE DEVELOPMENT OF AN AIDS VACCINE: THE AIDS VACCINE FOR
ASIA NETWORK (AVAN)
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE AIDS; accelerating; vaccine; AIDS Vaccine for Asia Network (AVAN)
ID RESEARCH-AND-DEVELOPMENT; PHASE-I TRIAL; VIRUS-VACCINE; HIV-1 VACCINE;
DOUBLE-BLIND; THAILAND; EVALUATE; IMMUNOGENICITY; VOLUNTEERS; ENTERPRISE
AB HIV/AIDS is a major public health problem worldwide, especially in developing countries. The development of a safe and effective HIV vaccine is central to stopping the epidemic and would be a great public health tool. The AIDS Vaccine for Asia Network (AVAN) is a group of concerned investigators committed to assisting regional and global HIV vaccine efforts. AVAN's focus on improving the coordination and harmonization of research, ethical reviews, clinical trial capacity regulatory frameworks, vaccine manufacturing, community participation, and government advocacy could help accelerate HIV vaccine efforts in the region. At a meeting in November 2010, researchers from various countries in Asia presented their progress in HIV vaccine research and development. Six working groups discussed the current status, gaps and methods to strengthen capacity and infrastructure in various areas related to AIDS vaccine research and development. These discussions led to the development of prioritized action plans for the next 5 years. This report describes the gaps and challenges HIV vaccine research faces in the region and recommends improvement and standardization of facilities, and coordination and harmonization of all activities related to AIDS vaccine research and development, including possible technology transfer when a vaccine becomes available.
C1 [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Chiu, Joseph; Benenson, Michael] Armed Forces Res Inst Med Sci, US Mil HIV Res Program, Bangkok 10400, Thailand.
[Kent, Stephen J.] Univ Melbourne, Melbourne, Vic 3010, Australia.
[Tamashiro, Hiko] Hokkaido Univ, Sapporo, Hokkaido, Japan.
[Manrique, Amapola; Bernstein, Alan] Global HIV Vaccine Enterprise, New York, NY USA.
[Ditangco, Rossana A.] Res Inst Trop Med, Manila, Philippines.
[Cooper, David A.] Univ NSW, Sydney, NSW, Australia.
[Osmanov, Saladin] World Hlth Org Joint United Nations Programme HIV, Geneva, Switzerland.
[Mathieson, Bonnie] NIH, Off AIDS Res, Washington, DC USA.
[Sandstrom, Eric] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
[Esparza, Jose] Bill & Melinda Gates Fdn, Seattle, WA USA.
[Hoff, Rodney] Reg Emerging Dis Intervent Ctr, Singapore, Singapore.
[Shao, Yiming] Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China.
RP Pitisuttithum, P (reprint author), Mahidol Univ, Fac Trop Med, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM tmppt@mahidol.ac.th
RI Tamashiro, Hidehiko/B-2403-2013;
OI Kent, Stephen/0000-0002-8539-4891
FU World Health Organization; WHO-UNAIDS; Global HIV Vaccine Enterprise;
International AIDS Vaccine Initiative (IAVI); US National Institutes of
Health (NIH); US Military HIV Research Program (MHRP); Department of
Disease Control, Ministry of Public Health, Thailand
FX The annual meeting was sponsored by the World Health Organization and
the joint United Nations Programme on HIV/AIDS (WHO-UNAIDS), the Global
HIV Vaccine Enterprise, the International AIDS Vaccine Initiative
(IAVI), the US National Institutes of Health (NIH), the US Military HIV
Research Program (MHRP), and the Department of Disease Control, Ministry
of Public Health, Thailand. The organizers are extremely grateful to all
the participants and appreciate their presence and contributions which
were critical to the success of the meeting. The organizers are also
thankful to Michael Benenson, Deena Kanagaraj, Sabine Majer, Wai Lin
Htun, Kaoru Takahashi, Ahmed Abdi Dahir, Yoshi Inakuma for their support
as rapporteurs and Daoumpai Suwattanasilp, Sawanya Lekhachinnabut,
Bussabong Nillawat, and Patcharanant Thanarojpongsatorn for their
assistance in organizing the meeting.
NR 23
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U1 0
U2 4
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD SEP
PY 2011
VL 42
IS 5
BP 1130
EP 1146
PG 17
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 824FC
UT WOS:000295186800012
PM 22299439
ER
PT J
AU White, JM
Cannon, JW
Stannard, A
Markov, NP
Spencer, JR
Rasmussen, TE
AF White, Joseph M.
Cannon, Jeremy W.
Stannard, Adam
Markov, Nickolay P.
Spencer, Jerry R.
Rasmussen, Todd E.
TI Endovascular balloon occlusion of the aorta is superior to resuscitative
thoracotomy with aortic clamping in a porcine model of hemorrhagic shock
SO SURGERY
LA English
DT Article; Proceedings Paper
CT 6th Annual Academic Surgical Congress
CY FEB 01-03, 2011
CL Huntington Beach, CA
SP Assoc Acad Surg (AAS), Soc Univ Surg (SUS)
ID EMERGENCY-DEPARTMENT THORACOTOMY; CARDIOPULMONARY-RESUSCITATION;
ANEURYSMS; SURVIVAL; OUTCOMES
AB Background. Noncompressible torso hemorrhage is the leading Cause of potentially preventable death on the modern battlefield. The objective of this study is to characterize resuscitative aortic balloon occlusion (BO) compared to thoracotomy with aortic clamping in a model of hemorrhagic shock.
Methods. A total of 18 swine (3 groups; 6 animals/group) were used in this study. Swine in class IV shock underwent no aortic occlusion (NO), thoracotomy and clamp occlusion (CO), or endovascular BO. Animals in the NO group underwent direct placement of a temporary vascular shunt (TVS) at the injury site, whereas animals in the CO and BO groups underwent aortic occlusion before TVS placement. Hemodynamic and physiologic measures were collected.
Results. The central aortic pressure, carotid blood flow and brain oxygenation as measured by oximetry increased in the CO and BO groups compared to the NO group (P < .05). During resuscitation, the BO group was less acidotic than the CO group (pH, 7.35 vs 7.24; P < .05) with a lower serum lactate level (4.27 vs 6.55; P < .05) and pCO2 level (43.5 vs 49.9; P < .05). During resuscitation, the BO group required less fluid (667 mL vs 2,166 mL; P < .05) and norepinephrine (0 mcg vs 52.1 mcg; P < .05) than the CO group.
Conclusion. Resuscitative aortic BO increases central perfusion pressures with less physiologic disturbance than thoracotomy with aortic clamping in a model of hemorrhagic shock. Endovascular BO of the aorta should be explored further as an option in the management of noncompressible torso hemorrhage. (Surgery 2011;150:400-9.)
C1 [White, Joseph M.; Cannon, Jeremy W.; Stannard, Adam; Markov, Nickolay P.; Spencer, Jerry R.; Rasmussen, Todd E.] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA.
[Stannard, Adam] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Cannon, Jeremy W.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers,Suite B, Ft Sam Houston, TX 78236 USA.
EM todd.rasmussen@amedd.army.mil
NR 26
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U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD SEP
PY 2011
VL 150
IS 3
BP 400
EP 409
DI 10.1016/j.surg.2011.06.010
PG 10
WC Surgery
SC Surgery
GA 823FQ
UT WOS:000295108300005
PM 21878225
ER
PT J
AU Chow, BJW
Small, G
Yam, Y
Chen, L
Achenbach, S
Al-Mallah, M
Berman, DS
Budoff, MJ
Cademartiri, F
Callister, TQ
Chang, HJ
Cheng, V
Chinnaiyan, KM
Delago, A
Dunning, A
Hadamitzky, M
Hausleiter, J
Kaufmann, P
Lin, F
Maffei, E
Raff, GL
Shaw, LJ
Villines, TC
Min, JK
AF Chow, Benjamin J. W.
Small, Gary
Yam, Yeung
Chen, Li
Achenbach, Stephan
Al-Mallah, Mouaz
Berman, Daniel S.
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor
Chinnaiyan, Kavitha M.
Delago, Augustin
Dunning, Allison
Hadamitzky, Martin
Hausleiter, Joerg
Kaufmann, Philipp
Lin, Fay
Maffei, Erica
Raff, Gilbert L.
Shaw, Leslee J.
Villines, Todd C.
Min, James K.
CA CONFIRM Investigators
TI Incremental Prognostic Value of Cardiac Computed Tomography in Coronary
Artery Disease Using CONFIRM COroNary Computed Tomography Angiography
Evaluation for Clinical Outcomes: An InteRnational Multicenter Registry
SO CIRCULATION-CARDIOVASCULAR IMAGING
LA English
DT Article
DE computed tomography; coronary angiography; prognosis; all-cause
mortality; left ventricular ejection fraction
ID DIAGNOSTIC PERFORMANCE; VENTRICULAR-FUNCTION; CT ANGIOGRAPHY; HIGH-RISK;
ATHEROSCLEROSIS; METAANALYSIS; PREDICTION; MANAGEMENT; MORTALITY;
SEVERITY
AB Background-Large multicenter studies validating the prognostic value of coronary computed tomographic angiography (CCTA) and left ventricular ejection fraction (LVEF) are lacking. We sought to confirm the independent and incremental prognostic value of coronary artery disease (CAD) severity measured using 64-slice CCTA over LVEF and clinical variables.
Methods and Results-A large international multicenter registry (CONFIRM Registry) was queried, and CCTA patients with LVEF data on CCTA were screened. Patients with a history of myocardial infarction, coronary revascularization, or cardiac transplantation were excluded. The National Cholesterol Education Program-Adult Treatment Panel III risk was calculated for each patient, and CCTA was evaluated for CAD severity (normal, nonobstructive, non-high-risk, or high-risk CAD) and LVEF < 50%. Patients were followed for an end point of all-cause mortality; 27 125 patients underwent CCTA at 12 participating centers, with a total of 14 064 patients meeting the analysis criteria. Follow-up was available for 13 966 (99.3%) patients (mean follow-up of 22.5 months; 95% confidence interval, 22.3 to 22.7 months). All-cause mortality (271 deaths) occurred in 0.65% of patients without coronary atherosclerosis, 1.99% of patients with nonobstructive CAD, 2.90% of patients with non-high-risk CAD, and 4.95% for patients with high-risk CAD. Multivariable analysis confirmed that LVEF < 50% (hazard ratio, 2.74; 95% confidence interval, 2.12 to 3.51) and CAD severity (hazard ratio, 1.58; 95% confidence interval, 1.42 to 1.76) were predictors of all-cause mortality, and CAD severity had incremental value over LVEF and clinical variables.
Conclusions-Our results demonstrate that CCTA measures of CAD severity and LVEF have independent prognostic value. Incorporation of CAD severity provides incremental value for predicting all-cause death over routine clinical predictors and LVEF in patients with suspected obstructive CAD. (Circ Cardiovasc Imaging. 2011;4:463-472.)
C1 [Chow, Benjamin J. W.; Small, Gary; Yam, Yeung; Chen, Li] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON K1Y 4W7, Canada.
[Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany.
[Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA.
[Berman, Daniel S.; Cheng, Victor] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA.
[Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA.
[Cademartiri, Filippo; Maffei, Erica] Univ Parma, Dept Radiol, I-43100 Parma, Italy.
[Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA.
[Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
[Raff, Gilbert L.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI USA.
Capitol Cardiol Associates, Albany, NY USA.
Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA.
[Lin, Fay; Min, James K.] New York Presbyterian Hosp, New York, NY USA.
[Hadamitzky, Martin; Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, Munich, Germany.
[Kaufmann, Philipp] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
[Lin, Fay; Min, James K.] Weill Cornell Med Coll, Dept Med, New York, NY USA.
[Lin, Fay; Min, James K.] Weill Cornell Med Coll, Dept Radiol, New York, NY USA.
[Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
[Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
RP Chow, BJW (reprint author), Univ Ottawa, Inst Heart, Dept Med Cardiol, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada.
EM bchow@ottawaheart.ca
RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016;
OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei,
Erica/0000-0002-0388-4433; Villines, Todd/0000-0003-2674-3702;
Al-Mallah, Mouaz/0000-0003-2348-0484
FU Canadian Institute of Health Research [MSH-83718]; Swiss National
Science Foundation; GE Healthcare; Pfizer; AstraZeneca; TeraRecon Inc.;
Siemens; Bayer Schering Pharma; Bayer Pharma; Blue Cross Blue Shield
Blue Care MI
FX Dr Chow was supported by Canadian Institute of Health Research: New
Investigator Award No. MSH-83718. Dr Kaufman was supported by the Swiss
National Science Foundation.; Dr Chow received research support from GE
Healthcare, Pfizer, and AstraZeneca; fellowship support from GE
Healthcare; and educational support from TeraRecon Inc. Dr Achenbach
received grant support from Siemens and Bayer Schering Pharma and is a
consultant for Servier. Dr Budoff is on the speaker's bureau for GE
Healthcare. Dr Cademartiri received grant support from GE Healthcare, is
a consultant for Servier, and is on the speaker's bureau of Bracco. Dr
Chinnaiyan received grant support from Bayer Pharma and Blue Cross Blue
Shield Blue Care MI. Dr Kaufmann received grant support from the Swiss
National Science Foundation and GE Healthcare. Dr Maffei received grant
support from GE Healthcare. Dr Min received research support and is on
the speaker's bureau for GE Healthcare. Dr Raff received grant support
from Siemens, Blue Cross Blue Shield Blue Care MI, and Bayer Pharma.
NR 32
TC 94
Z9 99
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1941-9651
J9 CIRC-CARDIOVASC IMAG
JI Circ.-Cardiovasc. Imaging
PD SEP
PY 2011
VL 4
IS 5
BP 463
EP 472
DI 10.1161/CIRCIMAGING.111.964155
PG 10
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
Medical Imaging
GA 822FY
UT WOS:000295030600004
PM 21730027
ER
PT J
AU Sollanek, KJ
Kenefick, RW
Cheuvront, SN
Axtell, RS
AF Sollanek, Kurt J.
Kenefick, Robert W.
Cheuvront, Samuel N.
Axtell, Robert S.
TI Potential impact of a 500-mL water bolus and body mass on plasma
osmolality dilution
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Dehydration; Hypohydration; Hydration assessment; Total body water;
Fluid intake
ID HYDRATION STATUS; FLUID RESTRICTION; ACUTE DEHYDRATION; OLDER-ADULTS;
THIRST; VOLUME; OSMOREGULATION; HYPERTONICITY; HYPOHYDRATION;
REPLACEMENT
AB A methodological discrepancy exists in the hydration assessment literature regarding the establishment of euhydration, as some investigations utilize a prehydration technique, while others do not (overnight fluid/food fast). However, the degree that plasma osmolality (P(osm)) dilutes when using the pre-hydration method and how body mass/composition might influence the results is not known. Thirty subjects (22 M, 8 F; 20 +/- 2 years (mean +/- SD); 1.8 +/- 0.1 m; 75.8 +/- 13.5 kg) had P(osm) measured after an 8-h food and fluid fast (overnight fast) and 90 min after a 500-mL (4-9 mL/kg) water bolus (prehydration). From pre- to post-bolus, participants' P(osm) declined from 297 +/- 3.5 to 295 +/- 3.8 mmol/kg (p < 0.05; Delta -1.7 +/- 3.5 mmol/kg). One-third of the sample diluted to more than -3 mmol/kg. The effect of body mass on P(osm) dilution was investigated by comparing dilution in the ten lightest (62.8 +/- 3.4 kg) and heaviest (92.0 +/- 9.8 kg) participants; however, the change between the light (Delta -1.9 +/- 3.8 mmol/kg) versus heavy groups (Delta -1.1 +/- 3.0 mmol/kg) was not different (p > 0.05). The correlation between body mass or total body water and change in P(osm) was weak (p > 0.05), as was the correlation between relative fluid intake based on mass and change in P(osm) (p > 0.05). The two methodologies appear to produce similar P(osm) values when measured in most individuals. However, the potential for significant dilution (>3 mmol/kg) should be considered when choosing the pre-hydration methodology.
C1 [Sollanek, Kurt J.; Kenefick, Robert W.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
[Sollanek, Kurt J.; Axtell, Robert S.] So Connecticut State Univ, Human Performance Lab, New Haven, CT 06515 USA.
RP Sollanek, KJ (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
EM Kurt.Sollanek@us.army.mil
NR 28
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD SEP
PY 2011
VL 111
IS 9
BP 1999
EP 2004
DI 10.1007/s00421-011-1833-3
PG 6
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 821GM
UT WOS:000294963000005
PM 21249384
ER
PT J
AU Rantalainen, T
Hoffren, M
Linnamo, V
Heinonen, A
Komi, PV
Avela, J
Nindl, BC
AF Rantalainen, Timo
Hoffren, M.
Linnamo, V.
Heinonen, A.
Komi, P. V.
Avela, J.
Nindl, B. C.
TI Three-month bilateral hopping intervention is ineffective in initiating
bone biomarker response in healthy elderly men
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Randomized controlled study; RCT; Bone biochemical markers; Exercise;
Impact
ID HIGH-IMPACT EXERCISE; GROUND REACTION FORCES; MINERAL DENSITY;
OSTEOPOROTIC FRACTURES; PHYSICAL-ACTIVITY; TRAINING-PROGRAM; VERTICAL
JUMP; RISK-FACTORS; LOWER-LIMB; WOMEN
AB In animal studies, bone adaptation has been initiated successfully without the transient force spike associated with high impact exercises. Consequently, a 12-week bilateral hopping on the balls of the feet intervention was conducted. 25 elderly men (age 72(SD4) years, height 171(6) cm, weight 75(9) kg) were randomly assigned into exercise and control groups. Ten subjects in each group completed the study. Carboxyterminal propeptide of type I collagen (CICP), bone-specific alkaline phosphatase (bALP) and carboxyterminal telopeptide of type I collagen (CTx) were measured from venous blood samples at baseline, at 2 weeks and at the end of the intervention. Maximal ground reaction force (GRF), osteogenic index (OI) and jump height (JH) were determined from bilateral hopping test and balance was assessed with velocity of center of pressure (COP(velocity)) while standing on the preferred leg with eyes open. The intervention consisted of 5-7 sets of 10 s timed bilateral hopping exercise at 75-90% intensity three times/week. There was no significant group 9 time interaction for GRF, OI and JH (P = 0.065). GRF (11% change from baseline vs. 4%), OI (15 vs. 6%) and COP(velocity) (-10 vs. -1%) were not influenced by the intervention (P > 0.170), while the control group improved JH (P = 0.031) (2 vs. 18%). For the biomarkers, no effect was observed in MANOVA (P = 0.536) or in univariate analyses (P = 0.082 to P = 0.820) (CICP -2 vs. -3%, CTx 8 vs. -12%, bALP 0 vs. -3.7%). Allowing transient impact force spikes may be necessary to initiate a bone response in elderly men as the intervention was ineffective.
C1 [Rantalainen, Timo; Hoffren, M.; Linnamo, V.; Komi, P. V.; Avela, J.; Nindl, B. C.] Univ Jyvaskyla, Dept Biol Phys Activ, Neuromuscular Res Ctr, SF-40100 Jyvaskyla, Finland.
[Rantalainen, Timo] Lappeenranta Univ Technol, Dept Mech Engn, Lappeenranta, Finland.
[Rantalainen, Timo; Heinonen, A.] Univ Jyvaskyla, Dept Hlth Sci, SF-40100 Jyvaskyla, Finland.
[Nindl, B. C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
RP Rantalainen, T (reprint author), Univ Jyvaskyla, Dept Biol Phys Activ, Neuromuscular Res Ctr, SF-40100 Jyvaskyla, Finland.
EM timo.j.rantalainen@jyu.fi
RI Rantalainen, Timo/B-2950-2013; Heinonen, Ari/A-9199-2014;
OI Heinonen, Ari/0000-0002-3681-9953; Rantalainen, Timo/0000-0001-6977-4782
FU European regional development fund; Academy of Finland; TBGS National
Graduate School of Musculoskeletal Disorders and Biomaterials
FX The study was funded by the European regional development fund, the
Academy of Finland and by the TBGS National Graduate School of
Musculoskeletal Disorders and Biomaterials. The opinions or assertions
contained herein are the private views of the author(s) and are not to
be construed as official or reflecting the views of the Army or the
Department of Defense.
NR 49
TC 6
Z9 6
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD SEP
PY 2011
VL 111
IS 9
BP 2155
EP 2162
DI 10.1007/s00421-011-1849-8
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 821GM
UT WOS:000294963000023
PM 21298444
ER
PT J
AU Valenti, MC
Torrieri, D
Ferrett, T
AF Valenti, Matthew C.
Torrieri, Don
Ferrett, Terry
TI Noncoherent Physical-Layer Network Coding with FSK Modulation: Relay
Receiver Design Issues
SO IEEE TRANSACTIONS ON COMMUNICATIONS
LA English
DT Article
DE Network coding; two-way relay channel; frequency-shift keying;
noncoherent reception; channel estimation
ID FADING CHANNELS; INTERFERENCE
AB A channel-coded physical-layer network coding strategy is refined for practical operation. The system uses frequency-shift keying (FSK) modulation and operates noncoherently, providing advantages over coherent operation: there are no requirements for perfect power control, phase synchronism, or estimates of carrier-phase offset. In contrast with analog network coding, which relays received analog signals plus noise, the system relays digital network codewords, obtained by digital demodulation and channel decoding at the relay. The emphasis of this paper is on the relay receiver formulation. Closed-form expressions are derived that provide bitwise log-likelihood ratios, which may be passed through a standard error-correction decoder. The role of fading-amplitude estimates is investigated, and an effective fading-amplitude estimator is developed. Simulation results are presented for a Rayleigh block-fading channel, and the influence of block length is explored. An example realization of the proposed system demonstrates a 32.4% throughput improvement compared to a similar system that performs network coding at the link layer. By properly selecting the rates of the channel codes, this benefit may be achieved without requiring an increase in transmit power.
C1 [Valenti, Matthew C.; Ferrett, Terry] W Virginia Univ, Morgantown, WV 26506 USA.
[Torrieri, Don] USA, Res Lab, Adelphi, MD USA.
RP Valenti, MC (reprint author), W Virginia Univ, Morgantown, WV 26506 USA.
EM valenti@ieee.org; dtorr@arl.army.mil; terry.ferrett@ieee.org
OI Ferrett, Terry/0000-0002-9919-9544; Valenti, Matthew/0000-0001-6089-0509
FU National Science Foundation [CNS-0750821]; United States Army Research
Laboratory [W911NF-10-0109]
FX M. C. Valenti's contribution was sponsored by the National Science
Foundation under Award No. CNS-0750821, and by the United States Army
Research Laboratory under Contract W911NF-10-0109.
NR 22
TC 19
Z9 21
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0090-6778
J9 IEEE T COMMUN
JI IEEE Trans. Commun.
PD SEP
PY 2011
VL 59
IS 9
BP 2595
EP 2604
DI 10.1109/TCOMM.2011.063011.110030
PG 10
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 821ZO
UT WOS:000295013200029
ER
PT J
AU Henning, PC
Park, BS
Kim, JS
AF Henning, Paul C.
Park, Bong-Sup
Kim, Jeong-Su
TI Physiological Decrements During Sustained Military Operational Stress
SO MILITARY MEDICINE
LA English
DT Article
ID PROLONGED PHYSICAL STRAIN; GROWTH-FACTOR-I; ACTIVATED PROTEIN-KINASE;
HIGH CALORIE DIET; SLEEP-DEPRIVATION; ENERGY DEFICIENCY; YOUNG MEN;
METABOLIC-RESPONSES; UBIQUITIN LIGASES; TRAINING-PROGRAM
AB Missions conducted by the U.S. Military during combat involve a multitude of operational stressors that can cause deterioration in physical and military performance of soldiers. Physiological consequences of sustained operational stress include decrements in anabolic hormones, skeletal muscle mass, and loss of bone mineral density. The objective of this review is to examine the current literature and provide commanders with information on the physical and physiological decrements in soldiers conducting sustained operations. The intent is that this will provide commanders with insight on how to plan for missions to incorporate possible countermeasures to enhance or sustain warfighter performance.
C1 [Henning, Paul C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Park, Bong-Sup; Kim, Jeong-Su] Florida State Univ, Coll Human Sci, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA.
RP Henning, PC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
NR 84
TC 10
Z9 11
U1 0
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2011
VL 176
IS 9
BP 991
EP 997
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 821KU
UT WOS:000294974700008
PM 21987955
ER
PT J
AU Lynn, DC
De Lorenzo, RA
AF Lynn, David C.
De Lorenzo, Robert A.
TI Advising and Assisting an Iraqi Army Medical Clinic: Observations of a
US Military Support Mission
SO MILITARY MEDICINE
LA English
DT Article
AB Medical civil-military operations are important for deployed military medical units engaged in counterinsurgency missions. There are few reports on military support for a host nation's military medical infrastructure, and we describe an initiative of the 21st Combat Support Hospital in 2010 during the postsurge phase of Operation Iraqi Freedom and Operation New Dawn. The goal was to incrementally improve the quality of care provided by Iraqi 7th Army medical personnel using existing clinic infrastructure and a low budget. Direct bedside teaching to include screening and treatment of ambulatory patients (sick call), focused pharmacy and medical supply system support, medical records documentation, and basic infection control compliance were the objectives. Lessons learned include the requirement to implement culturally relevant changes, maintain focus on system processes, and maximize education and mentorship through multiple modalities. In summary, a combat hospital can successfully implement an advise and assist mission with minimal external resources.
C1 [Lynn, David C.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28310 USA.
[De Lorenzo, Robert A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[De Lorenzo, Robert A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
RP Lynn, DC (reprint author), Womack Army Med Ctr, Dept Surg, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
NR 9
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2011
VL 176
IS 9
BP 998
EP 1002
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 821KU
UT WOS:000294974700009
PM 21987956
ER
PT J
AU Rossen, LM
Pollack, KM
Canham-Chervak, M
Canada, S
Baker, SP
AF Rossen, Lauren M.
Pollack, Keshia M.
Canham-Chervak, Michelle
Canada, Sara
Baker, Susan P.
TI Motor Vehicle Crashes Among Active Duty US Army Personnel, 1999 to 2006
SO MILITARY MEDICINE
LA English
DT Article
ID IRAQI-FREEDOM; MILITARY; INJURY; PREVENTION; INTERVENTIONS; REVIEWS
AB In the U.S. Army, motor vehicle crashes (MVCs), both privately owned and military, are a leading cause of injury and death. Few studies have described the distribution and trends of MVCs among Army personnel, which may have been impacted by current military missions. This descriptive study of risk factors and select outcomes is from safety report data maintained by the U.S. Army Combat Readiness/Safety Center on 11,469 active duty Army personnel involved in MVCs, 1999-2006. The majority (66%) of Soldiers in MVCs were in military vehicles within the continental United States (68%). The average age of individuals involved in MVCs was 27.7 years old. Males had a consistently higher MVC rate than females. The average cost per MVC related to property damage and injuries was $36,039 and $24,038, respectively. Results suggest a need for additional exploration of MVCs involving Army vehicles, which were the most common and among the most costly.
C1 [Rossen, Lauren M.; Pollack, Keshia M.; Baker, Susan P.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
[Canham-Chervak, Michelle; Canada, Sara] USA, Injury Prevent Program, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA.
RP Rossen, LM (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, 624 N Broadway, Baltimore, MD 21205 USA.
FU Defense Safety Oversight Council through Concurrent Technologies
Corporation
FX This project is funded by the Defense Safety Oversight Council through
Concurrent Technologies Corporation in June 2007.
NR 22
TC 3
Z9 3
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2011
VL 176
IS 9
BP 1019
EP 1026
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 821KU
UT WOS:000294974700013
PM 21987960
ER
PT J
AU Stetz, MC
Kaloi-Chen, JY
Turner, DD
Bouchard, S
Riva, G
Wiederhold, BK
AF Stetz, Melba C.
Kaloi-Chen, Janale Y.
Turner, David D.
Bouchard, Stephane
Riva, Giuseppe
Wiederhold, Brenda K.
TI The Effectiveness of Technology-Enhanced Relaxation Techniques for
Military Medical Warriors
SO MILITARY MEDICINE
LA English
DT Article
ID MENTAL-HEALTH-SERVICES; STRESS-MANAGEMENT; DEPLOYMENT; AFGHANISTAN;
DISORDERS; PERSONNEL; THERAPY; IRAQ; CARE
AB Combat zones can be very stressful for those in the area. Even in the battlefield, military medical personnel are expected to save others, while also staying alive. In this study, half of a sample of deployed military medical warriors (total n = 60) participated in technology-assisted relaxation training. Learning relaxation skills with a video clip of virtual reality relaxing scenes showed a statistically significant impact on the anxiety levels of the Experimental Group.
C1 [Stetz, Melba C.; Kaloi-Chen, Janale Y.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Turner, David D.] Western Hemisphere Inst Secur Cooperat, Ft Benning, GA 31905 USA.
[Bouchard, Stephane] Univ Quebec Gatineau, Dept Psychoeduc & Psychol, Gatineau, PQ J8X 3X7, Canada.
[Riva, Giuseppe] Univ Cattolica Sacro Cuore, I-20123 Milan, Italy.
[Wiederhold, Brenda K.] Virtual Real Med Ctr, San Diego, CA 92121 USA.
RP Stetz, MC (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RI Riva, Giuseppe/C-5917-2008
OI Riva, Giuseppe/0000-0003-3657-106X
FU Army Medical Department Medical Technology Initiative; Telemedicine and
Advanced Research Center (TATRC), U.S., Army Medical Research and
Materiel Command, Fort Detrick MD
FX We thank the US Army Medical Research and Materiel Command (USARMC) for
allowing Stetz to work in one of its laboratories, the US Army
Aeromedical Research Laboratory and helping fund this research effort
through its Army Medical Department Advanced Medical Technology
Initiative, Telemedicine and Advanced Technology Research Center
(TATRC). We also wish to thank COL James McGhee, Dr. John Crowley, Dr.
Morris Lattimore, the members of the local Scientific Review/Human Use
committees, Ms. Elizabeth Stokes, Ms. Jameela Montgomery, Ms. JoAnn
Finney, Mr. Brad Erickson, SGT William Schober, Ms. Christina
Standridge, Mr. Scott Childress, SGT L. Palacio, and CDT Katrina
Gerding. Many thanks to COL Friedl, John Winston, and John Day for
helping us with the funding mechanism: Army Medical Department Medical
Technology Initiative, Telemedicine and Advanced Research Center
(TATRC), U.S., Army Medical Research and Materiel Command, Fort Detrick
MD. TATRC has been involved in many partnerships with universities and
federal agencies supporting well over 500 research projects.
NR 38
TC 7
Z9 7
U1 2
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2011
VL 176
IS 9
BP 1065
EP 1070
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 821KU
UT WOS:000294974700020
PM 21987967
ER
PT J
AU Kosisky, SE
Marks, MS
Yacovone, MA
Nelson, MR
AF Kosisky, Susan E.
Marks, Mariko S.
Yacovone, Margaret A.
Nelson, Michael R.
TI Determination of ranges for reporting pollen aeroallergen levels in the
Washington, DC, metropolitan area
SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
LA English
DT Article
ID BURKARD SPORE TRAP; AMBROSIA-ARTEMISIIFOLIA L.; ALLERGIC RHINITIS;
SPATIAL VARIABILITY; CLINICAL ALLERGY; ROTOROD SAMPLER; OLEA-EUROPAEA;
COUNTS; POLLINOSIS; SYMPTOMS
AB Background: Local aeroallergen monitoring provides useful information for the atopic patient and medical community. Currently, National Allergy Bureau (NAB) ranges are used for reporting pollen count levels in the Washington, DC, area.
Objective: To determine standard range criteria (low, moderate, high, and very high) for the reporting of specific tree, grass, and weed aeroallergens representative of the Washington, DC, metropolitan region.
Methods: Atmospheric sampling for pollen aeroallergens was performed using a volumetric rotating-arm impaction sampler (model 40 Rotorod, SDI Company, Plymouth Meeting, PA). The cumulative pollen count, over a 12-year period (1998-2009), was determined for specific pollen aeroallergens. Local ranges were developed using methodology previously employed to determine NAB ranges. A comparison was made between NAB and Washington, DC, area ranges.
Results: The local median count, and low and moderate range criteria, are markedly lower than NAB range counts for tree, grass, and weed pollen. The NAB 99th percentile (high) count is significantly higher for grass and weed pollen but lower for tree pollen. Using new local range criteria, an increase was seen in the number of high days recorded for weed pollen (1,300%), grass pollen (258.6%), and tree pollen (11.8%). Previously, using NAB range criteria, no very high days were reported for grass and weed pollen over the 12-year period.
Conclusion: Washington, DC, ranges establish more relevant reporting standards for our local patient population and will allow for comparison with reporting levels developed for sampling locations nationwide as well as with other regional sites. Ann Allergy Asthma Immunol. 2011;107:244-250.
C1 [Kosisky, Susan E.; Marks, Mariko S.; Yacovone, Margaret A.; Nelson, Michael R.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA.
RP Kosisky, SE (reprint author), USA, Centralized Allergen Extract Lab, Bldg 512,9100 Brookeville Rd, Silver Spring, MD 20910 USA.
EM Susan.Kosisky@amedd.army.mil
NR 38
TC 4
Z9 4
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1081-1206
J9 ANN ALLERG ASTHMA IM
JI Ann. Allergy Asthma Immunol.
PD SEP
PY 2011
VL 107
IS 3
BP 244
EP 250
DI 10.1016/j.anai.2011.05.003
PG 7
WC Allergy; Immunology
SC Allergy; Immunology
GA 820CF
UT WOS:000294882400013
PM 21875544
ER
PT J
AU Franz, DR
LeDuc, JW
AF Franz, David R.
LeDuc, James W.
TI BALANCING OUR APPROACH TO THE INSIDER THREAT
SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE
LA English
DT Editorial Material
C1 [Franz, David R.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[LeDuc, James W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX USA.
RP Franz, DR (reprint author), 110 Thomas Johnson Dr,Suite 170, Frederick, MD 21702 USA.
EM dfranz@mriglobal.org
NR 0
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1538-7135
J9 BIOSECUR BIOTERROR
JI Biosecur. Bioterror.
PD SEP
PY 2011
VL 9
IS 3
BP 205
EP 206
DI 10.1089/bsp.2011.0052
PG 2
WC Public, Environmental & Occupational Health; International Relations
SC Public, Environmental & Occupational Health; International Relations
GA 818PU
UT WOS:000294767100002
PM 21819224
ER
PT J
AU Mondello, S
Gabrielli, A
Catani, S
D'Ippolito, M
Tortella, F
Schmid, K
Wang, KK
Hayes, RL
Formisano, R
AF Mondello, S.
Gabrielli, A.
Catani, S.
D'Ippolito, M.
Tortella, F.
Schmid, K.
Wang, K. K.
Hayes, R. L.
Formisano, R.
TI PREDICTIVE VALUE OF SERUM BRAIN BIOMARKER IN CHRONIC DISORDERS OF
CONSCIOUSNESS AFTER SEVERE NEUROTRAUMA: A CASE REPORT
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Meeting Abstract
CT 15th Congress of the European-Federation-of-Neurological-Societies
(EFNS)
CY SEP 10-13, 2011
CL Budapest, HUNGARY
SP European Federat Neurol Soc
C1 [Mondello, S.; Gabrielli, A.; Wang, K. K.; Hayes, R. L.] Univ Florida, Gainesville, FL USA.
[Mondello, S.; Wang, K. K.; Hayes, R. L.] Banyan Biomarkers Inc, Alachua, FL USA.
[D'Ippolito, M.] Santa Lucia Fdn, Gainesville, Italy.
[Catani, S.; Formisano, R.] Santa Lucia Fdn, Rome, Italy.
[Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Schmid, K.] Walter Reed Army Inst Res, Gainesville, MD USA.
RI Mondello, Stefania/A-1813-2012
OI Mondello, Stefania/0000-0002-8587-3614
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-5101
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD SEP
PY 2011
VL 18
SU 2
SI SI
BP 313
EP 313
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 819DW
UT WOS:000294806600569
ER
PT J
AU Roesel, T
AF Roesel, T.
TI A PROPOSED OBSERVATIONAL STUDY TO DETERMINE WHETHER VITAMIN D DEFICIENCY
ATTENUATES PROGESTERONE EFFECTIVENESS IN TRAUMATIC BRAIN INJURY
TREATMENT
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Meeting Abstract
CT 15th Congress of the European-Federation-of-Neurological-Societies
(EFNS)
CY SEP 10-13, 2011
CL Budapest, HUNGARY
SP European Federat Neurol Soc
C1 [Roesel, T.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Roesel, T.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-5101
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD SEP
PY 2011
VL 18
SU 2
SI SI
BP 315
EP 315
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 819DW
UT WOS:000294806600573
ER
PT J
AU Dasary, SSR
Singh, AK
Senapati, D
Yu, HT
Dubey, M
Amirtharaj, P
Ray, PC
AF Dasary, Samuel Suman Raj
Singh, Anant Kumar
Senapati, Dulal
Yu, Hongtao
Dubey, Madan
Amirtharaj, Paul
Ray, Paresh Chandra
TI Ultrasensitive and Highly Selective Detection of TNT From Environmental
Sample Using Two-Photon Scattering Properties of
Aminothiophenol-Modified Gold Nanoparticle
SO IEEE TRANSACTIONS ON NANOTECHNOLOGY
LA English
DT Article
DE Explosive; gold nanoparticle; plasmon; trinitrotoluene (TNT); two-photon
scattering (TPS)
ID HYPER-RAYLEIGH SCATTERING; NONLINEAR-OPTICAL PROPERTIES;
2,4,6-TRINITROTOLUENE TNT; CONJUGATED POLYMERS; AU NANOPARTICLES;
LIGHT-SCATTERING; SURFACE; DNA; SPECTROSCOPY; SIZE
AB The detection of illegally transported explosives materials has become important for assuring safety at airports and air travel. Trinitrotoluene (TNT) is also one of the most commonly used nitroaromatic explosives for landmines of military and terrorist activities. As a result, there is an urgent need for rapid and reliable methods for the detection of trace amount of TNT for screening in airport, analyzing forensic samples, and environmental analysis. Driven by the need to detect trace amounts of TNT from environmental samples, this paper demonstrates a label-free ultrasensitive and highly selective two-photon scattering (TPS) assay using aminothiophenol-modified gold nanoparticle for TNT recognition in 120 picomolar (pM) level from environmental sample. Our experimental results show that TNT can be detected quickly and accurately in pM level with excellent discrimination against other nitro compounds from environmental sample. A detailed mechanism for significant TPS intensity change has been discussed.
C1 [Dasary, Samuel Suman Raj; Singh, Anant Kumar; Senapati, Dulal; Yu, Hongtao; Ray, Paresh Chandra] Jackson State Univ, Jackson, MS 39217 USA.
[Dubey, Madan; Amirtharaj, Paul] USA, Res Lab, Adelphi, MD 20783 USA.
RP Dasary, SSR (reprint author), Jackson State Univ, Jackson, MS 39217 USA.
EM paresh.c.ray@jsums.edu
FU Department of Defense [W 912HZ-06-C-0057]; National Science Foundation
(NSF) [DMR-0611539]; NSF Center for Research Excellence in Science and
Technology [HRD-0833178]
FX This work was supported by the Department of Defense under Grant W
912HZ-06-C-0057, by the National Science Foundation (NSF) Partnership
for Research & Education in Materials under Grant DMR-0611539, and by
the NSF Center for Research Excellence in Science and Technology under
Grant HRD-0833178. The review of this paper was arranged by Associate
Editor J Li.
NR 37
TC 8
Z9 8
U1 0
U2 18
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1536-125X
J9 IEEE T NANOTECHNOL
JI IEEE Trans. Nanotechnol.
PD SEP
PY 2011
VL 10
IS 5
BP 1083
EP 1088
DI 10.1109/TNANO.2011.2107918
PG 6
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Materials Science, Multidisciplinary; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Materials Science;
Physics
GA 819VS
UT WOS:000294860800026
ER
PT J
AU Khavrutskii, IV
Wallqvist, A
AF Khavrutskii, Ilja V.
Wallqvist, Anders
TI Improved Binding Free Energy Predictions from Single-Reference
Thermodynamic Integration Augmented with Hamiltonian Replica Exchange
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID ACCELERATED MOLECULAR-DYNAMICS; SOLVATION FREE-ENERGIES; HYDRATION
FREE-ENERGIES; LIGAND-BINDING; EFFICIENT GENERATION; LAMBDA-DYNAMICS;
ATOMIC CHARGES; AM1-BCC MODEL; T4 LYSOZYME; SIMULATIONS
AB Reliable predictions of relative binding free energies are essential in drug discovery, where chemists modify promising compounds with the aim of increasing binding affinity. Conventional thermodynamic integration (TI) approaches can estimate corresponding changes in binding free energies but suffer from inadequate sampling due to the ruggedness of the molecular energy surfaces. Here, we present an improved TI strategy for computing relative binding free energies of congeneric ligands. This strategy employs a specific, unphysical single-reference (SR) state and Hamiltonian replica exchange (HREX) to locally enhance sampling. We then apply this strategy to compute relative binding free energies of 12 ligands in the L99A mutant of T4 lysozyme. Besides the ligands, our approach enhances hindered rotations of the important V111 as well as V87 and L118 side chains. Concurrently, we devise practical strategies to monitor and improve HREX-SRTI efficiency. Overall, the HREX-SRTI results agree well (R-2 = 0.76, RMSE = 0.3 kcal/mol) with available experimental data. When optimized for efficiency, the HREX-SRTI precision matches that of experimental measurements.
C1 [Khavrutskii, Ilja V.; Wallqvist, Anders] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Khavrutskii, IV (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM ikhavrutskii@bioanalysis.org
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Department of Defense under High Performance Computing Software
Applications Institutes (HSAI) initiative
FX We would like to thank Dr. In-Chul Yeh, Dr. Michael S. Lee, and Dr.
Hyung-June Woo for stimulating scientific discussions. Also, we
acknowledge the National Cancer Institute (NCI) for an allocation of
computing time and staff support at the Advanced Biomedical Computing
Center (ABCC) at National Cancer Institute, Frederick, Maryland. This
work was sponsored by the U.S. Department of Defense High Performance
Computing Modernization Program (HPCMP) under the High Performance
Computing Software Applications Institutes (HSAI) initiative.
Disclaimer: The opinions and assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the U.S. Army or the U.S. Department of Defense.
NR 78
TC 16
Z9 16
U1 1
U2 15
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD SEP
PY 2011
VL 7
IS 9
BP 3001
EP 3011
DI 10.1021/ct2003786
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 818XQ
UT WOS:000294790400035
PM 22046108
ER
PT J
AU Wachman, GS
Labuz, JF
AF Wachman, Gregory S.
Labuz, Joseph F.
TI Soil-Structure Interaction of an Earth Pressure Cell
SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Calibration; Contact pressure; Earth pressure; Soil stress;
Soil-structure interaction
AB The output from an earth pressure cell (EPC) is usually related to the normal stress in soil through fluid calibration, where a known pressure is applied to the EPC and the output is recorded. However, distribution of normal stress within a soil is not uniform, and the EPC is not an ideal membrane-bending stiffness affects the response. These factors complicate the performance of the EPC. A calibration procedure for an EPC is reviewed, and it is shown that these controversial sensors can provide an accurate measure of average normal stress if calibrated in soil at a given density. In addition, a soil-structure interaction model is proposed to explain why soil calibration is necessary. DOI: 10.1061/(ASCE)GT.1943-5606.0000501. (C) 2011 American Society of Civil Engineers.
C1 [Labuz, Joseph F.] Univ Minnesota, Dept Civil Engn, Minneapolis, MN 55455 USA.
[Wachman, Gregory S.] US Army Corps Engineers, St Paul, MN 55101 USA.
RP Labuz, JF (reprint author), Univ Minnesota, Dept Civil Engn, Minneapolis, MN 55455 USA.
EM jlabuz@umn.edu
OI Labuz, Joseph/0000-0002-7549-0644
NR 10
TC 4
Z9 7
U1 0
U2 12
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1090-0241
J9 J GEOTECH GEOENVIRON
JI J. Geotech. Geoenviron. Eng.
PD SEP
PY 2011
VL 137
IS 9
BP 843
EP 845
DI 10.1061/(ASCE)GT.1943-5606.0000501
PG 3
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA 818UD
UT WOS:000294780300003
ER
PT J
AU Savant, G
Berger, C
McAlpin, TO
Tate, JN
AF Savant, Gaurav
Berger, Charlie
McAlpin, Tate O.
Tate, Jennifer N.
TI Efficient Implicit Finite-Element Hydrodynamic Model for Dam and Levee
Breach
SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE
LA English
DT Article
DE Finite-element model; Implicit solver; Dam and levee failure;
Pseudo-transient continuation; Adaptive hydraulics; ADH
ID SHALLOW-WATER EQUATIONS; VOLUME METHOD; EULER EQUATIONS; UPWIND METHODS;
SIMULATION
AB This technical paper presents the development and application of a pseudo-transient continuation (PTC)-inspired flow model for the simulation of dam and levee failure. The unstructured, implicit, Petrov-Galerkin finite-element model relies on computed residuals to automatically adjust the time-step size. The implicit time integration, together with the automatic time-step size selection through PTC, makes the model computationally efficient. The model is verified and applied to several analytic and real-world test cases that exercise model behavior and accuracy for several critical, transcritical, and subcritical flows. The result is an efficient and accurate prediction of both the speed and depth of shock waves as the dam-break flow passes over initially dry and wet land. DOI: 10.1061/(ASCE)HY.1943-7900.0000372. (C) 2011 American Society of Civil Engineers.
C1 [Savant, Gaurav] Dynam Solut LLC, Vicksburg, MS 39180 USA.
[Savant, Gaurav; Berger, Charlie; McAlpin, Tate O.; Tate, Jennifer N.] USA, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
RP Savant, G (reprint author), Dynam Solut LLC, Vicksburg, MS 39180 USA.
EM gaurav.savant@usace.army.mil; charlie.berger@usace.army.mil;
tate.o.mcalpin@usace.army.mil; jennifer.n.tate@usace.army.mil
FU U.S. Army Corps of Engineers
FX The results presented in this paper were obtained through research
sponsored by the U.S. Army Corps of Engineers Systemwide Water Resources
Program (SWWRP). Permission was granted by the Chief of Engineers to
publish this information.
NR 21
TC 9
Z9 9
U1 1
U2 10
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9429
J9 J HYDRAUL ENG-ASCE
JI J. Hydraul. Eng.-ASCE
PD SEP
PY 2011
VL 137
IS 9
BP 1005
EP 1018
DI 10.1061/(ASCE)HY.1943-7900.0000372
PG 14
WC Engineering, Civil; Engineering, Mechanical; Water Resources
SC Engineering; Water Resources
GA 818UF
UT WOS:000294780600012
ER
PT J
AU Deng-Bryant, Y
Prins, ML
Hovda, DA
Harris, NG
AF Deng-Bryant, Ying
Prins, Mayumi L.
Hovda, David A.
Harris, Neil G.
TI Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not
Adult Rats after Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE ketogenic diet; nuclear magnetic resonance spectroscopy; phosphorus;
proton; TBI
ID PROTON-MAGNETIC-RESONANCE; CORTICAL IMPACT INJURY; CEREBRAL
GLUCOSE-UTILIZATION; MITOCHONDRIAL DYSFUNCTION; N-ACETYLASPARTATE;
MICROWAVE IRRADIATION; P-31-NMR SPECTROSCOPY; EMISSION-TOMOGRAPHY;
NAD(+) DEPLETION; CONTUSION INJURY
AB Previous studies have shown that the change of cerebral metabolic rate of glucose (CMRglc) in response to traumatic brain injury (TBI) is different in young (PND35) and adult rats (PND70), and that prolonged ketogenic diet treatment results in histological and behavioral neuroprotection only in younger rat brains. However, the mechanism(s) through which ketones act in the injured brain and the biochemical markers of their action remain unknown. Therefore, the current study was initiated to: 1) determine the effect of injury on the neurochemical profile in PND35 compared to PND70 rats; and 2) test the effect of early post-injury administration of ketogenic diet on brain metabolism in PND35 versus PND70 rats. The data show that alterations in energy metabolites, amino acid, and membrane metabolites were not evident in PND35 rats on standard diet until 24 h after injury, when the concentration of most metabolites was reduced from sham-injured values. In contrast, acute, but transient deficits in energy metabolism were measured at 6 h in PND70 rats, together with deficits in N-acetylaspartate that endured until 24 h. Administration of a ketogenic diet resulted in significant increases in plasma beta-hydroxybutyrate (beta OHB) levels. Similarly, brain beta OHB levels were significantly elevated in all injured rats, but were elevated by 43% more in PND35 rats compared to PND70 rats. As a result, ATP, creatine, and phosphocreatine levels at 24 h after injury were significantly improved in the ketogenic PND35 rats, but not in the PND70 group. The improvement in energy metabolism in the PND35 brains was accompanied by the recovery of NAA and reduction of lactate levels, as well as amelioration of the deficits of other amino acids and membrane metabolites. These results indicate that the PND35 brains are more resistant to the injury, indicated by a delayed deficit in energy metabolism. Moreover, the younger brains revert to ketones metabolism more quickly than do the adult brains, resulting in better neurochemical and cerebral metabolic recovery after injury.
C1 [Deng-Bryant, Ying; Prins, Mayumi L.; Hovda, David A.; Harris, Neil G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA.
[Hovda, David A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
[Deng-Bryant, Ying; Prins, Mayumi L.; Hovda, David A.; Harris, Neil G.] Univ Calif Los Angeles, Brain Injury Res Ctr, Los Angeles, CA 90095 USA.
RP Deng-Bryant, Y (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave,Room 2W15, Silver Spring, MD 20910 USA.
EM ying.d.bryant@us.army.mil
RI Prins, Mayumi/J-9571-2015
OI Prins, Mayumi/0000-0001-7694-9739
FU UCLA Brain Injury Research Center; National Institutes of Health,
National Institute of Neurological Disorders and Stroke (NINDS)
[NS055910, NS058489]
FX We thank Dr. Brenda Bartnik-Olson for helpful comments on the manuscript
and Dr. David McArthur for help with statistics. This work was supported
by the UCLA Brain Injury Research Center and National Institutes of
Health Award Numbers NS055910 and NS058489 from the National Institute
of Neurological Disorders and Stroke (NINDS). The content is the sole
responsibility of the authors and does not necessarily represent
official views of the NINDS or the National Institutes of Health.
NR 81
TC 22
Z9 22
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD SEP
PY 2011
VL 28
IS 9
BP 1813
EP 1825
DI 10.1089/neu.2011.1822
PG 13
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 821AK
UT WOS:000294947000013
PM 21635175
ER
PT J
AU Legler, PM
Brey, RN
Smallshaw, JE
Vitetta, ES
Millard, CB
AF Legler, Patricia M.
Brey, Robert N.
Smallshaw, Joan E.
Vitetta, Ellen S.
Millard, Charles B.
TI Structure of RiVax: a recombinant ricin vaccine
SO ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
LA English
DT Article
ID A-CHAIN; PROTECTS MICE; TRANSITION-STATE; DISULFIDE BONDS; CELL EPITOPE;
TOXIN; INTOXICATION; ANTIBODIES; STABILITY; PROTEINS
AB RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1-267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 angstrom resolution and it was shown that it is superposable with that of the ricin toxin A-chain from Ricinus communis with a root-mean-square deviation of 0.6 angstrom over 258 C(alpha) atoms. The RiVax structure is also compared with the recently determined structure of another potential ricin-vaccine immunogen, RTA 1-33/44-198 R48C/T77C. Finally, the locations and solvent-exposure of two toxin-neutralizing B-cell epitopes were examined and it was found that these epitopes are within or near regions predicted to be involved in catalysis. The results demonstrate the composition of the RiVax clinical material and will guide ongoing protein-engineering strategies to develop improved immunogens.
C1 [Millard, Charles B.] USA, Med Res & Mat Command, Frederick, MD 21702 USA.
[Legler, Patricia M.] USN, Res Labs, Washington, DC 20375 USA.
[Brey, Robert N.] Soligenix Inc, Princeton, NJ 08540 USA.
[Smallshaw, Joan E.; Vitetta, Ellen S.] Univ Texas SW Med Ctr Dallas, Ctr Canc Immunobiol, Dallas, TX 75390 USA.
RP Millard, CB (reprint author), USA, Med Res & Mat Command, Frederick, MD 21702 USA.
EM charles.b.millard@us.army.mil
FU US Defense Threat Reduction Agency JSTO [S.S.0003_06_WR_B]; National
Institutes of Health [U01 A1082120-01]
FX This work was funded by the US Defense Threat Reduction Agency JSTO
award S.S.0003_06_WR_B (CBM) and National Institutes of Health U01
A1082120-01 (CBM). The opinions or assertions contained herein belong to
the authors and are not necessarily the official views of the US Army,
US Navy or the US Department of Defense.
NR 38
TC 13
Z9 14
U1 2
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0907-4449
J9 ACTA CRYSTALLOGR D
JI Acta Crystallogr. Sect. D-Biol. Crystallogr.
PD SEP
PY 2011
VL 67
BP 826
EP 830
DI 10.1107/S0907444911026771
PN 9
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biophysics; Crystallography
SC Biochemistry & Molecular Biology; Biophysics; Crystallography
GA 817QR
UT WOS:000294689400010
PM 21904036
ER
PT J
AU Kang, HJ
Kosoy, MY
Shrestha, SK
Shrestha, MP
Pavlin, JA
Gibbons, RV
Yanagihara, R
AF Kang, Hae Ji
Kosoy, Michael Y.
Shrestha, Sanjaya K.
Shrestha, Mrigendra P.
Pavlin, Julie A.
Gibbons, Robert V.
Yanagihara, Richard
TI Short Report: Genetic Diversity of Thottapalayam Virus, a Hantavirus
Harbored by the Asian House Shrew (Suncus murinus) in Nepal
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID EURASIAN COMMON SHREW; DISTINCT HANTAVIRUS; SEEWIS-VIRUS; NEWFOUND
HANTAVIRUS; HEMORRHAGIC-FEVER; BORNE HANTAVIRUS; UNITED-STATES; KOREA;
PHYLOGEOGRAPHY; SEQUENCES
AB Despite the recent discovery of genetically divergent hantaviruses in shrews of multiple species in widely separated geographic regions, data are unavailable about the genetic diversity and phylogeography of Thottapalayam virus (TPMV), a hantavirus originally isolated from an Asian house shrew (Suncus murinus) captured in southern India more than four decades ago. To bridge this knowledge gap, the S, M, and L segments of hantavirus RNA were amplified by reverse transcription polymerase chain reaction from archival lung tissues of Asian house shrews captured in Nepal from January to September 1996. Pair-wise alignment and comparison revealed approximately 80% nucleotide and > 94% amino acid sequence similarity to prototype TPMV. Phylogenetic analyses, generated by maximum likelihood and Bayesian methods, showed geographic-specific clustering of TPMV, similar to that observed for rodent- and soricid-borne hantaviruses. These findings confirm that the Asian house shrew is the natural reservoir of TPMV and suggest a long-standing virus host relationship.
C1 [Yanagihara, Richard] Univ Hawaii Manoa, Pacific Ctr Emerging Infect Dis Res, John A Burns Sch Med, Dept Pediat, Honolulu, HI 96813 USA.
Univ Hawaii Manoa, Dept Trop Med Med Microbiol & Pharmacol, John A Burns Sch Med, Honolulu, HI 96813 USA.
[Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Bacterial Dis Branch, Ft Collins, CO USA.
[Shrestha, Sanjaya K.; Shrestha, Mrigendra P.] Walter Reed Armed Forces Res Inst Med Sci, Res Unit Nepal, Kathmandu, Nepal.
[Pavlin, Julie A.] Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Gibbons, Robert V.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand.
US Army Med Component, Armed Forces Res Inst Med Sci, Dept Global Emerging Infect, Bangkok, Thailand.
RP Yanagihara, R (reprint author), Univ Hawaii Manoa, Pacific Ctr Emerging Infect Dis Res, John A Burns Sch Med, Dept Pediat, 651 Ilalo St,BSB320L, Honolulu, HI 96813 USA.
EM hyeyun.kang@gmail.com; mck3@cdc.gov; shresthask@afrims.org;
shresthamp@afrims.org; japavlin@gmail.com; Robert.Gibbons@afrims.org;
yanagiha@pbrc.hawaii.edu
RI Valle, Ruben/A-7512-2013
FU National Institute of Allergy and Infectious Diseases [R01A1075057];
National Center for Research Resources, National Institutes of Health
[P20RR018727, G12RR003061]
FX This work was supported in part by U.S. Public Health Service Grant
R01A1075057 from the National Institute of Allergy and Infectious
Diseases and Grants P20RR018727 and G12RR003061 from the National Center
for Research Resources, National Institutes of Health.
NR 36
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Z9 11
U1 1
U2 7
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2011
VL 85
IS 3
BP 540
EP 545
DI 10.4269/ajtmh.2011.11-0034
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 816EL
UT WOS:000294581400028
PM 21896819
ER
PT J
AU Heiner, JD
Trabulsy, ME
AF Heiner, Jason D.
Trabulsy, Mario E.
TI Coping With the Death of a Patient in the Emergency Department
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Editorial Material
ID HOSPITAL DOCTORS; RESIDENTS; PSYCHIATRISTS; NOTIFICATION; EXPERIENCE;
SUICIDE; STRESS; IMPACT; CARE; COPE
C1 [Heiner, Jason D.] Madigan Army Med Ctr, Dept Emergency Med, Tacoma, WA 98431 USA.
[Trabulsy, Mario E.] Univ Vermont, Coll Med, Dept Emergency Med, Burlington, VT USA.
RP Heiner, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jason.heiner1@us.army.mil
NR 26
TC 3
Z9 3
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD SEP
PY 2011
VL 58
IS 3
BP 295
EP 298
DI 10.1016/j.annemergmed.2010.12.022
PG 4
WC Emergency Medicine
SC Emergency Medicine
GA 818KK
UT WOS:000294750400017
PM 21310507
ER
PT J
AU Wunderer, T
Chua, CL
Yang, ZH
Northrup, JE
Johnson, NM
Garrett, GA
Shen, HG
Wraback, M
AF Wunderer, Thomas
Chua, Christopher L.
Yang, Zhihong
Northrup, John E.
Johnson, Noble M.
Garrett, Gregory A.
Shen, Hongen
Wraback, Michael
TI Pseudomorphically Grown Ultraviolet C Photopumped Lasers on Bulk AlN
Substrates
SO APPLIED PHYSICS EXPRESS
LA English
DT Article
ID LIGHT-EMITTING-DIODES; QUANTUM-WELL LASER; NM; GAN
AB Optically pumped ultraviolet lasers were fabricated on low-defect-density bulk (0001) AlN substrates. Al(x)Ga(1-x)N/Al(y)Ga(1-y)N heterostructures were grown by metal-organic vapor phase epitaxy near atmospheric pressure. Time-resolved photoluminescence studies of the multiple quantum well emission show long decay times of 900 ps at room temperature and confirm the high structural quality of the epitaxial layers. Laser resonators with a length of about 1 mm were formed by cleaving the AlN crystal to obtain m-plane mirror facets. Lasing is demonstrated at a wavelength of 267 nm with a threshold power density as low as 126 kW/cm(2) at room temperature. The laser emission was transverse electrically polarized. (C) 2011 The Japan Society of Applied Physics
C1 [Wunderer, Thomas; Chua, Christopher L.; Yang, Zhihong; Northrup, John E.; Johnson, Noble M.] Palo Alto Res Ctr Inc, Palo Alto, CA 94304 USA.
[Garrett, Gregory A.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA.
RP Wunderer, T (reprint author), Palo Alto Res Ctr Inc, 3333 Coyote Hill Rd, Palo Alto, CA 94304 USA.
FU Defense Advanced Research Projects Agency under U.S. Army
[W911NF-10-02-0102]
FX The authors are pleased to acknowledge helpful discussions with M.
Kneissl, Technische Universitat Berlin, Germany, and with HexaTech Inc.,
Morrisville, NC, USA. The technical support provided by Cliff
Knollenberg, Bowen Cheng, Mark Teepe, and Brent Krusor is gratefully
acknowledged. The work was supported by the Defense Advanced Research
Projects Agency CMUVT Program (PM: Dr. John Albrecht) under U.S. Army
Cooperative Agreement No. W911NF-10-02-0102.
NR 19
TC 50
Z9 50
U1 2
U2 26
PU JAPAN SOC APPLIED PHYSICS
PI TOKYO
PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO,
102-0073, JAPAN
SN 1882-0778
J9 APPL PHYS EXPRESS
JI Appl. Phys. Express
PD SEP
PY 2011
VL 4
IS 9
AR 092101
DI 10.1143/APEX.4.092101
PG 3
WC Physics, Applied
SC Physics
GA 817LE
UT WOS:000294673300012
ER
PT J
AU Klemcke, HG
Joe, B
Rose, R
Ryan, KL
AF Klemcke, Harold G.
Joe, Bina
Rose, Rajiv
Ryan, Kathy L.
TI Life or Death? A Physiogenomic Approach to Understand Individual
Variation in Responses to Hemorrhagic Shock
SO CURRENT GENOMICS
LA English
DT Article
DE Controlled hemorrhage; epigenetic; genes; hemorrhagic shock; inbred
rats; QTL
ID QUANTITATIVE TRAIT LOCI; TRAUMATIC BRAIN-INJURY; BLOOD-PRESSURE QTL;
ZINC-FINGER NUCLEASES; SALT-SENSITIVE RATS; ACUTE LUNG INJURY; LEUKOCYTE
GENE-EXPRESSION; TRANSIENT FOCAL ISCHEMIA; GENOME-WIDE ASSOCIATION;
NEAR-ISOGENIC LINES
AB Severe hemorrhage due to trauma is a major cause of death throughout the world. It has often been observed that some victims are able to withstand hemorrhage better than others. For decades investigators have attempted to identify physiological mechanisms that distinguish survivors from nonsurvivors for the purpose of providing more informed therapies. As an alternative approach to address this issue, we have initiated a research program to identify genes and genetic mechanisms that contribute to this phenotype of survival time after controlled hemorrhage. From physiogenomic studies using inbred rat strains, we have demonstrated that this phenotype is a heritable quantitative trait, and is therefore a complex trait regulated by multiple genes. Our work continues to identify quantitative trait loci as well as potential epigenetic mechanisms that might influence survival time after severe hemorrhage. Our ultimate goal is to improve survival to traumatic hemorrhage and attendant shock via regulation of genetic mechanisms and to provide knowledge that will lead to genetically-informed personalized treatments.
C1 [Klemcke, Harold G.; Rose, Rajiv; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Joe, Bina] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Physiol Genom Lab, Toledo, OH 43614 USA.
RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM harold.klemcke@amedd.army.mil
NR 202
TC 3
Z9 3
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1389-2029
J9 CURR GENOMICS
JI Curr. Genomics
PD SEP
PY 2011
VL 12
IS 6
BP 428
EP 442
PG 15
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 820KM
UT WOS:000294904600006
PM 22379396
ER
PT J
AU Milner, E
Sousa, J
Pybus, B
Melendez, V
Gardner, S
Grauer, K
Moon, J
Carroll, D
Auschwitz, J
Gettayacamin, M
Lee, P
Leed, S
McCalmont, W
Norval, S
Tungtaeng, A
Zeng, Q
Kozar, M
Read, KD
Li, QG
Dow, G
AF Milner, Erin
Sousa, Jason
Pybus, Brandon
Melendez, Victor
Gardner, Sean
Grauer, Kristina
Moon, Jay
Carroll, Dustin
Auschwitz, Jennifer
Gettayacamin, Montip
Lee, Patricia
Leed, Susan
McCalmont, William
Norval, Suzanne
Tungtaeng, Anchalee
Zeng, Qiang
Kozar, Michael
Read, Kevin D.
Li, Qigui
Dow, Geoffrey
TI Characterization of in vivo metabolites of WR319691, a novel compound
with activity against Plasmodium falciparum
SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
LA English
DT Article
DE Mefloquine; Malaria; N-dealkylated metabolites; Brain levels
ID MEFLOQUINE; METHANOLS; EXPOSURE; MALARIA; BRAIN
AB WR319691 has been shown to exhibit reasonable Plasmodium falciparum potency in vitro and exhibits reduced permeability across MDCK cell monolayers, which as part of our screening cascade led to further in vivo analysis. Single-dose pharmacokinetics was evaluated after an IV dose of 5 mg/kg in mice. Maximum bound and unbound brain levels of WR319691 were 97 and 0.05 ng/g versus approximately 1,600 and 3.2 ng/g for mefloquine. The half-life of WR319691 in plasma was approximately 13 h versus 23 h for mefloquine. The pharmacokinetics of several N-dealkylated metabolites was also evaluated. Five of six of these metabolites were detected and maximum total and free brain levels were all lower after an IV dose of 5 mg/kg WR319691 compared to mefloquine at the same dose. These data provide proof of concept that it is feasible to substantially lower the brain levels of a 4-position modified quinoline methanol in vivo without substantially decreasing potency against P. falciparum in vitro.
C1 [Milner, Erin; Sousa, Jason; Pybus, Brandon; Melendez, Victor; Gardner, Sean; Grauer, Kristina; Moon, Jay; Carroll, Dustin; Auschwitz, Jennifer; Lee, Patricia; Leed, Susan; McCalmont, William; Zeng, Qiang; Kozar, Michael; Li, Qigui; Dow, Geoffrey] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD 20910 USA.
[Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Norval, Suzanne; Read, Kevin D.] Univ Dundee, Drug Discovery Unit, Div Biol Chem & Drug Discovery, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland.
RP Milner, E (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM erin.milner@amedd.army.mil
RI Sousa, Jason/A-9177-2011
FU Medicines for Malaria Venture; Military Infectious Diseases Research
Program (MIDRP); United States Department of Defense
FX We gratefully acknowledge substantial financial support from Medicines
for Malaria Venture, Military Infectious Diseases Research Program
(MIDRP), and the United States Department of Defense.
NR 12
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 0378-7966
J9 EUR J DRUG METAB PH
JI Eur. J. Drug Metabol. Pharmacokinet.
PD SEP
PY 2011
VL 36
IS 3
BP 151
EP 158
DI 10.1007/s13318-011-0047-8
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 818CT
UT WOS:000294728100005
PM 21751074
ER
PT J
AU Duncan, AD
Liechty, JM
Miller, C
Chinoy, G
Ricciardi, R
AF Duncan, Alaine D.
Liechty, Janet M.
Miller, Cathy
Chinoy, Gail
Ricciardi, Richard
TI Employee Use and Perceived Benefit of a Complementary and Alternative
Medicine Wellness Clinic at a Major Military Hospital: Evaluation of a
Pilot Program
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID AURICULAR ACUPUNCTURE; COMPASSION FATIGUE; STRESS SYMPTOMS; WAR STRESS;
INSOMNIA; HEALTH; CARE; PERSONNEL; BURNOUT; IMPACT
AB Objectives: The objectives of this study were to examine the feasibility of a weekly on-site complementary and alternative medicine (CAM) wellness clinic for staff at a military hospital, and to describe employees' perceptions of program effectiveness.
Setting: The study setting was the Restore & Renew (R) Wellness Clinic at a United States Department of Defense hospital.
Subjects: The subjects were hospital nurses, physicians, clinicians, support staff, and administrators.
Interventions: The walk-in wellness clinic was open 8: 00 AM-2:00 pm 1 day a week. Participants selected one or more modalities each visit: ear acupuncture, clinical acupressure, and Zero Balancing.(R)
Outcome measures: A self-report survey was done after each clinic visit to evaluate clinic features and perceived impact on stress-related symptoms, compassion for patients, sleep, and workplace or personal relationships.
Results: Surveys completed after first-time and repeat visits (n = 2,756 surveys) indicated that most participants agreed or strongly agreed they felt more relaxed after sessions (97.9%), less stress (94.5%), more energy (84.3%), and less pain (78.8%). Ninety-seven percent (97%) would recommend it to a co-worker. Among surveys completed after five or more visits, more than half (59%-85%) strongly agreed experiencing increased compassion with patients, better sleep, improved mood, and more ease in relations with co-workers. Perceived benefits were sustained and enhanced by number of visits. The most frequently reported health habit changes were related to exercise, stress reduction, diet/nutrition, and weight loss.
Conclusions: This evaluation suggests that a hospital-based wellness clinic based on CAM principles and modalities is feasible, well-utilized, and perceived by most participants to have positive health benefits related to stress reduction at work, improved mood and sleep, and lifestyle.
C1 [Duncan, Alaine D.] HealingWorks Restoring & Renewing Mil Families, Silver Spring, MD USA.
[Duncan, Alaine D.] Crossings Ctr Healing Tradit, Silver Spring, MD USA.
[Liechty, Janet M.] Univ Illinois, Sch Social Work, Urbana, IL 61801 USA.
[Liechty, Janet M.] Univ Illinois, Coll Med, Urbana, IL 61801 USA.
[Miller, Cathy] Soul Lightening Int, Clin Acupressure Training, Los Altos, CA USA.
[Ricciardi, Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Duncan, AD (reprint author), 8505 Fenton St,Suite 202, Silver Spring, MD 20910 USA.
EM alaine_duncan@yahoo.com
OI Liechty, Janet/0000-0001-5363-2448
FU HealingWorks: Restoring & Renewing Military Families; Jim and Carol
Trawick Foundation; Consumer Health Foundation; Balm Foundation
FX The authors wish to acknowledge the extraordinary military caregivers
who participated in this program evaluation and the CAM clinicians who
served them. Sponsored by HealingWorks: Restoring & Renewing Military
Families, a 501C3, nonprofit organization; the Jim and Carol Trawick,
Consumer Health, and Balm Foundations provided primary funding. Special
thanks go to MG Patricia Horoho for her leadership and strong support of
the project and this research.
NR 41
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U1 2
U2 20
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP
PY 2011
VL 17
IS 9
BP 809
EP 815
DI 10.1089/acm.2010.0563
PG 7
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 817JZ
UT WOS:000294669800010
PM 21834662
ER
PT J
AU Grosman, B
Shaik, OS
Helwig, BG
Leon, LR
Doyle, FJ
AF Grosman, Benyamin
Shaik, Osman S.
Helwig, Bryan G.
Leon, Lisa R.
Doyle, Francis J., III
TI A physiological systems approach to modeling and resetting of mouse
thermoregulation under heat stress
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE numerical modeling; heat stroke; hyperthermia; hypothermia; genetic
algorithm
ID TEMPERATURE RISE; HYPERTHERMIA; RADIATION; RESPONSES; STROKE; MICE
AB Grosman B, Shaik OS, Helwig BG, Leon LR, Doyle FJ 3rd. A physiological systems approach to modeling and resetting of mouse thermoregulation under heat stress. J Appl Physiol 111: 938-945, 2011. First published June 23, 2011; doi: 10.1152/japplphysiol.00519.2010.-Heat stroke (HS) is a serious civilian and military health issue. Due to the limited amount of experimental data available in humans, this study was conducted on a mouse mathematical model fitted on experimental data collected from mice under HS conditions, with the assumption there is good agreement among mammals. Core temperature (T(c)) recovery responses in a mouse model consist of hypothermia and delayed fever during 24 h of recovery that represent potential biomarkers of HS severity. The objective of this study was to develop a simulation model of mouse T(c) responses and identify optimal treatment windows for HS recovery using a three-dimensional predictive heat transfer simulation model. Several bioenergetic simulation variables, including nonlinear metabolic heat production (W/m(3)), temperature-dependent convective heat transfer through blood mass perfusion (W/m(3)), and activity-related changes in circadian T(c) were used for model simulation. The simulation results predicted the experimental data with few disparities. Using this simulation model, we tested a series of ambient temperature treatment strategies to minimize hypothermia and delayed fever to accelerate HS recovery. Using a genetic algorithm, we identified eight time segments (ambient temperature = 27, 30, 31, 29, 28, 28, 27, 26 degrees C) of 110 min total duration that optimized HS recovery in our model simulation.
C1 [Grosman, Benyamin; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
[Grosman, Benyamin; Shaik, Osman S.; Doyle, Francis J., III] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA.
[Helwig, Bryan G.; Leon, Lisa R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP Doyle, FJ (reprint author), Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
EM doyle@engineering.ucsb.edu
FU Institute for Collaborative Biotechnologies from US Army Research Office
[DFA01 447850-23016]
FX The authors acknowledge the financial support provided by the Institute
for Collaborative Biotechnologies through grant DFA01 447850-23016 from
the US Army Research Office.
NR 26
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U1 1
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP
PY 2011
VL 111
IS 3
BP 938
EP 945
DI 10.1152/japplphysiol.00519.2010
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 817QM
UT WOS:000294688900036
PM 21700894
ER
PT J
AU Lin, A
Patel, N
Yoo, D
DeMartelaere, S
Bouchard, C
AF Lin, Amy
Patel, Neha
Yoo, David
DeMartelaere, Sheri
Bouchard, Charles
TI Management of Ocular Conditions in the Burn Unit: Thermal and Chemical
Burns and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID AMNIOTIC MEMBRANE TRANSPLANTATION; DOSE INTRAVENOUS IMMUNOGLOBULINS;
SCLERAL CONTACT-LENS; SEVERE EYE BURNS; BOSTON KERATOPROSTHESIS;
CLINICAL-EXPERIENCE; CONJUNCTIVAL FLAPS; SURGICAL APPROACH; TISSUE
ADHESIVE; CORNEAL ULCERS
AB Patients in burn intensive care units suffer from potentially life-threatening conditions including thermal or chemical burns and Stevens-Johnson syndrome/toxic epidermal necrolysis. There is often involvement of the ocular surface or adnexal structures which may be present at the time of hospital admission or may develop later in the hospital course. This article will describe the types of ocular burns, the mechanisms and manifestations of Stevens-Johnson syndrome/toxic epidermal necrolysis, the circumstances that may influence outcome, and acute and long-term treatment strategies, including new and evolving options. (J Burn Care Res 2011;32:547-560)
C1 [Lin, Amy; Patel, Neha; Yoo, David; Bouchard, Charles] Loyola Univ, Med Ctr, Maywood, IL 60153 USA.
[DeMartelaere, Sheri] Brooke Army Med Ctr, San Antonio, TX USA.
RP Lin, A (reprint author), Loyola Univ, Med Ctr, 2160 S 1st Ave, Maywood, IL 60153 USA.
OI Lin, Amy/0000-0001-9783-1270
NR 110
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U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2011
VL 32
IS 5
BP 547
EP 560
DI 10.1097/BCR.0b013e31822b0f29
PG 14
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA 817PW
UT WOS:000294687300010
PM 21799437
ER
PT J
AU Hutfless, S
Matos, P
Talor, MV
Caturegli, P
Rose, NR
AF Hutfless, Susan
Matos, Peter
Talor, Monica V.
Caturegli, Patrizio
Rose, Noel R.
TI Significance of Prediagnostic Thyroid Antibodies in Women with
Autoimmune Thyroid Disease
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID SURVEY NHANES-III; NATIONAL-HEALTH; UNITED-STATES; AUTOANTIBODIES;
DISORDERS; SMOKING; SERUM; RISK; PREVALENCE; PREDICTION
AB Introduction: Antibodies to thyroglobulin (Tg), thyroperoxidase (TPO), and TSH receptor (TSH-R) are prevalent in autoimmune thyroid diseases. We aimed to assess whether females with Graves disease or Hashimoto thyroiditis are more likely than age-matched controls to have thyroid antibodies before clinical diagnosis and to measure the timing of antibody seroconversion.
Methods: This was a nested case-control study using the Department of Defense Serum Repository and the Defense Medical Surveillance System, 1998-2007. We assessed thyroid antibodies in the serum of 522 female, active-duty, military personnel including: 87 Graves disease cases, 87 Hashimoto thyroiditis cases, and 348 age matched controls. One serum sample was available at the time of the clinical diagnosis (+/- 6 months); three additional samples were retrieved from the repository up to 7 yr before the clinical diagnosis, for a total of 2088 samples.
Results: In Hashimoto thyroiditis, TPO antibodies were found in about 66% of the cases at all time points. Tg antibodies showed a similar stationary trend, at a lower prevalence of about 53% at all time points. No TSH-R antibodies were found. In Graves disease, TPO antibodies gradually increased from 31% at 5-7 yr priortodiagnosisto57% at diagnosis and Tg antibodies from 18 to 47%. TSH-R antibodies were present before diagnosis and showed an increasing prevalence from 2, 7, 20, to 55%.
Conclusions: Antibodies to Tg, TPO, and TSH-R precede by years the development of the diagnostic autoimmune thyroid diseases phenotype. Overall, the presence of thyroid antibodies in apparently healthy individuals should not be neglected. (J Clin Endocrinol Metab 96: E1466-E1471, 2011)
C1 [Hutfless, Susan] Johns Hopkins Univ Hosp, Div Gastroenterol & Hepatol, Baltimore, MD 21287 USA.
[Matos, Peter] Walter Reed Army Inst Res, Dept Prevent Med, Silver Spring, MD 20910 USA.
[Matos, Peter] Headquarters Joint Munit Command, JMC Command Surg, Rock Isl, IL 61299 USA.
[Talor, Monica V.; Caturegli, Patrizio; Rose, Noel R.] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21205 USA.
[Talor, Monica V.; Rose, Noel R.] Johns Hopkins Med Inst, Johns Hopkins Ctr Autoimmune Dis Res, Baltimore, MD 21205 USA.
[Caturegli, Patrizio; Rose, Noel R.] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
RP Hutfless, S (reprint author), Johns Hopkins Univ Hosp, Dept Med, Div Gastroenterol, 600 N Wolfe St,Blalock Bldg 449, Baltimore, MD 21287 USA.
EM shutfle1@jhmi.edu
OI Hutfless, Susan/0000-0002-6311-2611
FU American Autoimmune Related Disease Association; National Institutes of
Health [DK 55670]; Johns Hopkins Research Center for Autoimmune Disease
FX This work was supported by a grant from the American Autoimmune Related
Disease Association (to S.H.). P.C. was supported by National Institutes
of Health Grant DK 55670. This work was also supported by the Johns
Hopkins Research Center for Autoimmune Disease.
NR 19
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U1 0
U2 7
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2011
VL 96
IS 9
BP E1466
EP E1471
DI 10.1210/jc.2011-0228
PG 6
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 815VR
UT WOS:000294558600015
PM 21715532
ER
PT J
AU Wambeke, BW
Hsiang, SM
Liu, M
AF Wambeke, Brad W.
Hsiang, Simon M.
Liu, Min
TI Causes of Variation in Construction Project Task Starting Times and
Duration
SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE
LA English
DT Article
DE Labor productivity; Construction; Variation; Factor analysis
ID REDUCING VARIABILITY; IMPROVE PERFORMANCE; FACTOR MODEL; PRODUCTIVITY;
MOTIVATION; PRINCIPLE
AB In this research, variation is defined as the time difference between what was planned and what actually happened in terms of task starting times and duration. Variation in construction tasks is important as it can impact productivity performance. Construction projects consist of a large number of interdependent tasks. When the starting time and/or duration of one task varies, it can affect other downstream tasks and result in disruptions to the schedule and/or decreased productivity. The construction process is complex and involves numerous people with different levels of responsibility, which makes identifying the root causes of the variation difficult. A nationwide survey was administered to workers, foremen, and project managers to identify the most prevalent causes and magnitude of both starting time and task duration variation. Fifty individual causes of variation were divided into eight categories: prerequisite work, detailed design/working method, labor force, tools and equipment, material and components, work/job site conditions, management/supervision/information flow, and weather or external conditions. This research examined the similarities and differences in perceptions between craft workers, foremen, and project managers in terms of starting time and task duration variation. The top eight causes of starting time variation and top nine causes of task duration variation were identified. The research also quantitatively analyzed the underlying structure of the causes of variation using factor analysis. This was done by grouping the 50 individual causes into nine orthogonal factors that represent the underlying structure of the affecting causes. The findings will help construction project managers and field managers focus on the root causes of variation during planning in order to develop effective strategies to reduce variation and improve project productivity performance. DOI: 10.1061/(ASCE)CO.1943-7862.0000342. (C) 2011 American Society of Civil Engineers.
C1 [Wambeke, Brad W.; Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Wambeke, Brad W.] USA, Washington, DC USA.
[Wambeke, Brad W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA.
[Hsiang, Simon M.] N Carolina State Univ, Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA.
RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
EM bwwambek@ncsu.edu; simon.hsiang@ttu.edu; min_liu@ncsu.edu
NR 37
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U1 1
U2 20
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9364
J9 J CONSTR ENG M ASCE
JI J. Constr. Eng. Manage.-ASCE
PD SEP
PY 2011
VL 137
IS 9
BP 663
EP 677
DI 10.1061/(ASCE)CO.1943-7862.0000342
PG 15
WC Construction & Building Technology; Engineering, Industrial;
Engineering, Civil
SC Construction & Building Technology; Engineering
GA 818TM
UT WOS:000294778500004
ER
PT J
AU Simms, JE
Lobred, AR
AF Simms, Janet E.
Lobred, Anthony R.
TI Application of Magnetic Susceptibility for Wetlands Delineation
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Article
ID HYDRIC SOILS; REGIME; LOESS; RIVER
AB Wetlands are natural resources that are protected under federal regulations; therefore, the delineation of wetlands is necessary to ensure their protection. Standard methods used for delineating wetlands can be time consuming, or a wetland could be problematic, i.e., lacking hydrophytic vegetation or hydric soil indicators, or periodically lacking hydrologic indicators. A magnetic susceptibility study could be an additional technique used to aid in the delineation process. A study using magnetic susceptibility was undertaken in central Mississippi to identify the transitional zone or boundary between non-hydric (uplands) and hydric (wetlands) soils. The soils were silt loam with a minor percentage of sand. A survey line that traversed the transitional zone between wetland and upland on each end of the transect was revisited four times during a single year and once two years later. One survey was conducted a few weeks after the winter inundation (moderately wet soil conditions), one was conducted several months after inundation but immediately after some heavy rainfall (moderately wet soil conditions), and two were conducted several weeks or months after inundation or significant rainfall (dry soil conditions). There were measurable differences between the magnetic susceptibility values collected in the upland and wetland regions during each survey. One transitional zone was easily identified using magnetic susceptibility, exhibiting a sharp decrease in susceptibility values between the upland and wetland. The other transitional zone contained an intermediate ridge, which made demarcation of the zone less obvious. The measured magnetic susceptibility values were comparable for the respective upland, transition, and wetland regions, and the characteristics of the curves were similar for all time-periods. Overall, magnetic susceptibility proved to be a successful method for delineating a wetland in this area.
C1 [Simms, Janet E.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Lobred, Anthony R.] USA, Corps Engineers, Vicksburg, MS 39180 USA.
RP Simms, JE (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM janet.e.simms@usace.army.mil
FU U.S. Army Engineer Research and Development Center; U.S. Army Corps of
Engineers, Vicksburg District
FX This research was supported by the U.S. Army Engineer Research and
Development Center and the U.S. Army Corps of Engineers, Vicksburg
District. Permission to publish was granted by Director, Geotechnical
and Structures Laboratory.
NR 43
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U1 0
U2 5
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD SEP
PY 2011
VL 16
IS 3
BP 105
EP 114
PG 10
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA 817VC
UT WOS:000294703700002
ER
PT J
AU Ramirez, D
Emamipour, H
Vidal, EX
Rood, MJ
Hay, KJ
AF Ramirez, David
Emamipour, Hamidreza
Vidal, Eduardo X.
Rood, Mark J.
Hay, K. James
TI Capture and Recovery of Methyl Ethyl Ketone with Electrothermal-Swing
Adsorption Systems
SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE
LA English
DT Article
DE Adsorption; Electrothermal desorption; Activated carbon fibers; Organic
compounds; Air pollution
ID ORGANIC VAPORS; ACTIVATED CARBONS; AIR TREATMENT; CLOTH; REGENERATION;
EQUILIBRIUM; DESORPTION
AB The amount of organic vapors that are emitted to the atmosphere can be reduced with the use of electrothermal-swing adsorption (ESA) with activated carbon fiber cloth (ACFC). This paper describes a pilot-scale ESA system that was scaled up based on two ESA bench-scale systems. Each ESA system consists of two vessels with four ACFC cartridges. The bench-scale and pilot-scale systems were tested with adsorption and desorption cycles using gas streams containing 73-10,000 ppmv and from 170-940 ppmv methyl ethyl ketone, respectively. Total flow rate ranged from 5 sL/min to 140 sL/min for the bench unit and 1,700 sL/min for the pilot unit. Scale-up procedure of an ESA system from the bench-scale to the pilot-scale is presented for the first time. Scale-up was based on throughput ratio, length of unused bed, adsorption capacity, pressure drop, superficial gas velocity in the ACFC, organic vapor removal efficiency, duration of the adsorption cycle, duration of the regeneration cycle, liquid recovery efficiency, electrical power/energy applied to the ACFC cartridges, and temperature of the ACFC cartridges. DOI: 10.1061/(ASCE)EE.1943-7870.0000381. (C) 2011 American Society of Civil Engineers.
C1 [Ramirez, David] Texas A&M Univ, Dept Environm Engn, Kingsville, TX 78363 USA.
[Emamipour, Hamidreza; Rood, Mark J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
[Vidal, Eduardo X.] Empresa Municipal Telecomunicac Agua Potable Alca, Cuenca, Ecuador.
[Hay, K. James] ERDC CERL, Champaign, IL 61826 USA.
RP Ramirez, D (reprint author), Texas A&M Univ, Dept Environm Engn, Kingsville, TX 78363 USA.
EM kfdr000@tamuk.edu
RI Robertson, Simon/D-1549-2012
FU Engineer Research and Development Center (ERDC)-Construction Engineering
Research Laboratory (CERL), University of Illinois at Urbana-Champaign;
Texas A&M University-Kingsville; CONACYT-Mexico; International and Lake
Michigan States Section of the Air & Waste Management Association (AWMA)
FX The writers acknowledge support from the Engineer Research and
Development Center (ERDC)-Construction Engineering Research Laboratory
(CERL), University of Illinois at Urbana-Champaign, and Texas A&M
University-Kingsville. Scholarship support from CONACYT-Mexico and the
International and Lake Michigan States Section of the Air & Waste
Management Association (A&WMA) is also acknowledged.
NR 25
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U2 20
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9372
J9 J ENVIRON ENG-ASCE
JI J. Environ. Eng.-ASCE
PD SEP
PY 2011
VL 137
IS 9
BP 826
EP 832
DI 10.1061/(ASCE)EE.1943-7870.0000381
PG 7
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 818WD
UT WOS:000294785700008
ER
PT J
AU de Bejar, LA
AF de Bejar, Luis A.
TI Probability of Flood-Induced Overtopping of Barriers in
Watershed-Reservoir-Dam Systems
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
DE Hyetographs; Watershed hydrograph; Routing through a reservoir; Random
reservoir capacity; Reservoir hydrograph; Flood-induced overtopping;
Hazard curves
AB An engineering methodology is developed to build hazard curves to evaluate the probability of flood-induced overtopping of barriers in watershed-reservoir-dam systems. The probable maximum precipitation in the watershed under consideration and its distribution in time during the acting storm is estimated. Considering the effects of the local geology, soil, topography, and land use, a random representation of the storm hourly rain is translated into effective runoff, including losses due to evaporation, interception, and surface retention. The uncertainty in the hydrological characteristics of the drainage basin is captured by a random time to concentration. Random hourly unit graphs are constructed analytically for a convex watershed and convoluted with the storm time-history to result in the random hydrograph for the inflow flood into the reservoir of the dam system. Flood routing through the reservoir is then computed with or without noise in the model. The deterministic path leads to a hydrograph for the water level at the barrier upstream face. The stochastic path evaluates through simulation the probability density function of variates (at discrete times) of the nonstationary random process of this pool level. The characterization of the reservoir-pool maxima allows the estimation of the probability of barrier overtopping. DOI:10.1061/(ASCE)HE.1943-5584.0000361. (C) 2011 American Society of Civil Engineers.
C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP de Bejar, LA (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Luis.A.DeBejar@erdc.usace.army.mil
FU Department of the Army, Corps of Engineers, Headquarters; Office of the
Chief of Engineers; Army Engineer District representatives in the Field
Review Group
FX This investigation was conducted under the work unit "Failure Mechanisms
of Concrete Dams" of the Risk Analysis for Dam Safety Research Program,
part of the Research Program on Civil Works sponsored by the Department
of the Army, Corps of Engineers, Headquarters. The author gratefully
acknowledges the support and guidance provided by the Office of the
Chief of Engineers and by the Army Engineer District representatives in
the Field Review Group. Approved for public release; distribution is
unlimited. Permission to publish was granted by the Director of the
Geotechnical and Structures Laboratory, U.S. Army Engineer Research and
Development Center.
NR 15
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U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD SEP
PY 2011
VL 16
IS 9
BP 699
EP 709
DI 10.1061/(ASCE)HE.1943-5584.0000361
PG 11
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 818UH
UT WOS:000294780800001
ER
PT J
AU Tawatsin, A
Thavara, U
Chompoosri, J
Phusup, Y
Jonjang, N
Khumsawads, C
Bhakdeenuan, P
Sawanpanyalert, P
Asavadachanukorn, P
Mulla, MS
Siriyasatien, P
Debboun, M
AF Tawatsin, Apiwat
Thavara, Usavadee
Chompoosri, Jakkrawarn
Phusup, Yutthana
Jonjang, Nisarat
Khumsawads, Chayada
Bhakdeenuan, Payu
Sawanpanyalert, Pathom
Asavadachanukorn, Preecha
Mulla, Mir S.
Siriyasatien, Padet
Debboun, Mustapha
TI Insecticide Resistance in Bedbugs in Thailand and Laboratory Evaluation
of Insecticides for the Control of Cimex hemipterus and Cimex
lectularius (Hemiptera: Cimicidae)
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE bedbugs; insecticides; resistance; control; Thailand
ID COMMON BED BUG; PYRETHROID RESISTANCE
AB Bedbugs are found in many countries around the world, and in some regions they are resistant to numerous insecticides. This study surveyed bedbugs in Thailand and determined their resistance to insecticides. The surveys were carried out in six provinces that attract large numbers of foreign tourists: Bangkok, Chonburi, Chiang Mai, Ubon Ratchathani, Phuket, and Krabi. Bedbugs were collected from hotels and colonized in the laboratory to evaluate their resistance to insecticides. Cimex hemipterus (F.) was found in some hotels in Bangkok, Chonburi, Phuket, and Krabi, whereas Cimex lectularius L. was found only in hotels in Chiang Mai. No bedbugs were found in Ubon Ratchathani. The colonized bedbugs showed resistance to groups of insecticides, including organochlorines (dichlorodiphenyl trichloroethane, dieldrin), carbamates (bendiocarb, propoxur), organophosphates (malathion, fenitrothion), and pyrethroids (cyfluthrin, deltamethrin, permethrin, lambda-cyhalothrin, etofenprox) in tests using World Health Organization insecticide-impregnated papers. The new insecticides imidacloprid (neonicotinoid group), chlorfenapyr (pyrrole group), and fipronil (phenylpyrazole group) were effective against the bedbugs; however, organophosphate (diazinon), carbamates (fenobucarb, propoxur), and pyrethroids (bifenthrin, cypermethrin, esfenvalerate, etofenprox) were ineffective. Aerosols containing various pyrethroid insecticides with two to four different active ingredients were effective against the bedbugs. The results obtained from this study suggested that both species of bedbugs in Thailand have developed marked resistance to various groups of insecticides, especially those in the pyrethroid group, which are the most common insecticides used for pest control. Therefore, an integrated pest management should be implemented for managing bedbugs in Thailand.
C1 [Siriyasatien, Padet] Chulalongkorn Univ, Dept Parasitol, Fac Med, Bangkok 10330, Thailand.
[Tawatsin, Apiwat; Thavara, Usavadee; Chompoosri, Jakkrawarn; Phusup, Yutthana; Jonjang, Nisarat; Khumsawads, Chayada; Bhakdeenuan, Payu; Sawanpanyalert, Pathom] Minist Publ Hlth, Natl Inst Hlth, Dept Med Sci, Nonthaburi 11000, Thailand.
[Asavadachanukorn, Preecha] Chulalongkorn Univ, Dept Stat, Fac Commerce & Accountancy, Bangkok 10330, Thailand.
[Mulla, Mir S.] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA.
[Debboun, Mustapha] USA, Med Dept Ctr & Sch, San Antonio, TX 78234 USA.
RP Siriyasatien, P (reprint author), Chulalongkorn Univ, Dept Parasitol, Fac Med, Bangkok 10330, Thailand.
EM padet.s@chula.ac.th
FU National Research Council of Thailand [2552-68]
FX We are grateful to Yaowaluk Chanbang and Suttida Suwannayot, Faculty of
Agriculture, Chiang Mai University, for providing a colony of the C.
lectularius used in this study. We thank the staff of the Biology and
Ecology Section, National Institute of Health, Thailand, for their
assistance in the bedbug survey, laboratory culture of bedbugs, and
efficacy tests. This work was supported by the National Research Council
of Thailand (Grant 2552-68). This manuscript was approved to be
published by permission of the National Research Council of Thailand
(NRCT 0005/1147).
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PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD SEP
PY 2011
VL 48
IS 5
BP 1023
EP 1030
DI 10.1603/ME11003
PG 8
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 816FX
UT WOS:000294585200009
PM 21936321
ER
PT J
AU Hoel, DF
Zollner, GE
El-Hossary, SS
Fawaz, EY
Watany, N
Hanafi, HA
Obenauer, PJ
Kirsch, P
AF Hoel, D. F.
Zollner, G. E.
El-Hossary, S. S.
Fawaz, E. Y.
Watany, N.
Hanafi, H. A.
Obenauer, P. J.
Kirsch, P.
TI Comparison of Three Carbon Dioxide Sources on Phlebotomine Sand Fly
Capture in Egypt
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE compressed CO(2); Phlebotomus papatasi; CO(2) generator system;
surveillance; dry ice
ID US MILITARY OPERATIONS; TALLIL-AIR-BASE; L-LACTIC ACID; ZOONOTIC
CUTANEOUS LEISHMANIASIS; SOUTHERN EGYPT; FLIES; DIPTERA; 1-OCTEN-3-OL;
PSYCHODIDAE; AFGHANISTAN
AB Lighted Centers for Disease Control and Prevention (CDC) light traps were baited with carbon dioxide (CO(2)) produced from three different sources to compare the efficacy of each in collecting phlebotomine sand flies in Bahrif village, Aswan Governorate, Egypt. Treatments consisted of compressed CO(2) gas released at a rate of 250 ml/min, 1.5 kg of dry ice (replaced daily) sublimating from an insulated plastic container, CO(2) gas produced from a prototype FASTGAS (FG) CO(2) generator system (APTIV Inc., Portland, OR), and a CDC light trap without a CO(2) source. Carbon dioxide was released above each treatment trap's catch opening. Traps were placed in a 4 X 4 Latin square designed study with three replications completed after four consecutive nights in August 2007. During the study, 1,842 phlebotomine sand flies were collected from two genera and five species. Traps collected 1,739 (94.4%) Phlebotomus papatasi (Scopoli), 19 (1.0%) Phlebotomus sergenti, 64 (3.5%) Sergentomyia schwetzi, 16 (0.9%) Sergentomyia palestinensis, and four (0.2%) Sergentomyia tiberiadis. Overall treatment results were dry ice (541) > FG (504) > compressed gas (454) > no CO(2) (343). Total catches of P. papatasi were not significantly different between treatments, although CO(2)-baited traps collected 23-34% more sand flies than the unbaited (control) trap. Results indicate that the traps baited with a prototype CO(2) generator were as attractive as traps supplied with CO(2) sources traditionally used in sand fly surveillance efforts. Field-deployable CO(2) generators are particularly advantageous in remote areas where dry ice or compressed gas is difficult to obtain.
C1 [Hoel, D. F.] USN, Marine Corps Publ Hlth Ctr Detachment, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
[Zollner, G. E.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[El-Hossary, S. S.; Fawaz, E. Y.; Watany, N.; Hanafi, H. A.; Obenauer, P. J.] US Naval Med Res Unit 3, Cairo, Egypt.
[Kirsch, P.] Univ Queensland, Minerals Ind Safety & Hlth Ctr, Sustainable Minerals Inst, St Lucia, Qld 4072, Australia.
RP Hoel, DF (reprint author), USN, Marine Corps Publ Hlth Ctr Detachment, Ctr Med Agr & Vet Entomol, 1600 SW 23rd Dr, Gainesville, FL 32608 USA.
EM davidfhoel@yahoo.com
RI Kirsch, Philipp/F-5740-2011
OI Kirsch, Philipp/0000-0002-9188-5697
FU Deployed War-Fighter Protection Program
FX We thank Maria Badra for logistical and administrative support and Rania
Kaldas for help with sand fly processing at NAMRU-3. This work was
performed under a Cooperative Research and Development Agreement between
Walter Reed Army Institute of Research, NAMRU-3, and APTIV Inc., and was
supported in part by the Deployed War-Fighter Protection Program. D.F.H.
and P.J.O. are military service members, G.E.Z., S.S.E.H., E.Y.F., N.
W., and H.A.H. are employees of the U.S. Government, and P. K. is a
civilian employee of an Australian university. This work was prepared as
part of our official duties. Title 17 U.S.C. 105 provides that
"Copyright protection under this title is not available for any work of
the United States Government." Title 17 U.S.C. 101 defines a U.S.
Government work as a work prepared by a military service member or
employee of the U.S. Government as part of that person's official
duties.
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PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD SEP
PY 2011
VL 48
IS 5
BP 1057
EP 1061
DI 10.1603/ME11083
PG 5
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 816FX
UT WOS:000294585200013
PM 21936325
ER
PT J
AU Konitzer, LN
Gill, NW
Koppenhaver, SL
AF Konitzer, Lisa N.
Gill, Norman W.
Koppenhaver, Shane L.
TI Investigation of Abdominal Muscle Thickness Changes After Spinal
Manipulation in Patients Who Meet a Clinical Prediction Rule for Lumbar
Stabilization
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE low back pain; manual therapy; motor control exercise; ultrasound
imaging
ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; TRANSVERSUS ABDOMINIS;
EXERCISE PROGRAM; CLASSIFICATION APPROACH; INTERRATER RELIABILITY;
IMPORTANT DIFFERENCE; MULTIFIDUS MUSCLES; MEASUREMENT ERROR; OUTCOME
MEASURES
AB STUDY DESIGN: Prospective case series.
OBJECTIVES: To investigate changes in abdominal muscle thickness with ultrasound imaging, after spinal manipulative therapy (SMT), in a subgroup of patients with low back pain (LBP) who meet a proposed clinical prediction rule for lumbar stabilization exercise (LSE).
BACKGROUND: The characteristics of a subgroup of patients with LBP who respond clinically to LSE has been proposed. Although the pathoanatomical characteristics of this subgroup have not been determined, clinicians often assume that this type of LBP is related, in part, to neuromuscular deficits of the lateral abdominal muscles. Recent evidence suggests that SMT may facilitate abdominal muscle activity and, therefore, enhance exercises targeting these deficits.
METHODS: Nineteen patients (mean age +/- SD, 32.5 +/- 7.8 years; 11 female) with LBP, who met the criteria for LSE, underwent ultrasound imaging of the transversus abdominis (TrA) and internal oblique (IO) muscles before, immediately after, and 3 to 4 days after lumbopelvic SMT. Measurements of resting thickness, contracted thickness during the abdominal drawing-in maneuver, and percent thickness change from rest to contraction of the TrA and IO muscles were analyzed with repeated-measures analysis of variance. Numeric pain rating scale and Oswestry Disability Index data were also collected.
RESULTS: No significant differences in resting, contracted, or percent thickness change in the TrA or IO were found over the 3 time periods. There were statistically significant reductions in numeric pain rating scale and Oswestry Disability Index scores, but mean differences failed to meet the minimal clinically important difference.
CONCLUSION: The results provide preliminary evidence that TrA and IO muscle resting and contracted thicknesses do not change post-SMT in patients with LBP in the LSE subgroup. In addition, while reductions in pain and disability were noted, they were not clinically meaningful. J Orthop Sports Phys Ther 2011;41(9):666-674, Epub 12 July 2011. doi:10.2519/jospt.2011.3685
C1 [Konitzer, Lisa N.] Womack Army Med Ctr, Robinson Hlth Clin Phys Therapy, Ft Bragg, NC USA.
[Konitzer, Lisa N.; Gill, Norman W.] Army Baylor Univ, Brooke Army Med Ctr, San Antonio, TX USA.
[Koppenhaver, Shane L.] Grad Sch, Army Med Dept, US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
RP Konitzer, LN (reprint author), 209 Oakridge Ave, Fayetteville, NC 28305 USA.
EM lisa.konitzer@us.army.mil
NR 57
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U1 0
U2 4
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD SEP
PY 2011
VL 41
IS 9
BP 666
EP 674
DI 10.2519/jospt.2011.3685
PG 9
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 817UV
UT WOS:000294703000007
PM 21765224
ER
PT J
AU Croy, T
AF Croy, Theodore
TI Metallic Foreign Body in a Patient With Knee Pain
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA.
RP Croy, T (reprint author), US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA.
OI Croy, Theodore/0000-0002-3053-8974
NR 0
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U1 0
U2 0
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD SEP
PY 2011
VL 41
IS 9
BP 696
EP 696
DI 10.2519/jospt.2011.0419
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 817UV
UT WOS:000294703000011
PM 21885912
ER
PT J
AU Vatamanu, J
Cao, LL
Borodin, O
Bedrov, D
Smith, GD
AF Vatamanu, Jenel
Cao, Liulei
Borodin, Oleg
Bedrov, Dmitry
Smith, Grant D.
TI On the Influence of Surface Topography on the Electric Double Layer
Structure and Differential Capacitance of Graphite/Ionic Liquid
Interfaces
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; TEMPERATURE IONIC LIQUIDS; MODEL; SIZE
AB Molecular simulations reveal that the shape of differential capacitance (DC) versus the electrode potential can change qualitatively with the structure of the electrode surface. Whereas the atomically flat basal plane of graphite in contact with a room-temperature ionic liquid generates camel-shaped DC, the atomically corrugated prismatic face of graphite with the same electrolyte exhibits bell-shaped behavior and much larger DCs at low double-layer potentials. The observed bell-shaped and camel-shaped DC behavior was correlated with the structural changes occurring in the double layer as a function of applied potential. Therefore, the surface topography clearly influences DC behavior, suggesting that attention should be paid to the electrode surface topography characterization in the studies of DC to ensure reproducibility and unambiguous interpretation of experimental results. Furthermore, our results suggest that controlling the electrode roughness/structure could be a route to improving the energy densities in electric double-layer capacitors.
C1 [Vatamanu, Jenel; Cao, Liulei; Bedrov, Dmitry; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Borodin, Oleg] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA.
EM u0615401@utah.edu
RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012
OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608
FU U.S. Department of Energy [DE-SC00019112, DE-AC02-05CH11231]; Office of
Science of the U.S. Department of Energy [DE-AC02-05CH11231]
FX We are grateful to U.S. Department of Energy under contract grant
DE-SC00019112 and contract no. DE-AC02-05CH11231 on PO no. 6838611
(University of Utah). This research used resources of the National
Energy Research Scientific Computing Center, which is supported by the
Office of Science of the U.S. Department of Energy under Contract No.
DE-AC02-05CH11231.
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U2 45
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD SEP 1
PY 2011
VL 2
IS 17
BP 2267
EP 2272
DI 10.1021/jz200879a
PG 6
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 817UJ
UT WOS:000294701800033
ER
PT J
AU Souza, L
Weltzin, JF
Sanders, NJ
AF Souza, Lara
Weltzin, Jake F.
Sanders, Nathan J.
TI Differential effects of two dominant plant species on community
structure and invasibility in an old-field ecosystem
SO JOURNAL OF PLANT ECOLOGY
LA English
DT Article
DE compensation; establishment; invasive; Lespedeza cuneata; Solidago;
Verbesina
ID MOUNTAINS-NATIONAL-PARK; GENOTYPIC DIVERSITY; TALLGRASS PRAIRIE;
GRASSLAND; INVASION; BIODIVERSITY; COMPETITION; REMOVAL; RESPONSES;
PRODUCTIVITY
AB Aims
In this study, we examined the effects of Solidago altissima (hereafter Solidago) and two species in the genus Verbesina, Verbesina virginica and Verbesina occidentalis (hereafter Verbesina), on the structure of an old-field plant community and establishment by an invasive plant species, Lespedeza cuneata (hereafter Lespedeza).
Methods
We removed Solidago, Verbesina and both Solidago and Verbesina from 4-m(2) plots in an intact old-field community during two growing seasons. We then quantified the effects of these removals on richness, evenness, diversity and composition of the subdominant plant community. We also measured the total aboveground biomass and the aboveground biomass of the subdominant community. To assess how these removals affected establishment by Lespedeza, we planted 20 seeds in each plot and tracked seedling emergence and survival for one growing season.
Important Findings
Subdominant community evenness and Shannon diversity were higher in plots from which Solidago and Verbesina were removed relative to control plots. However, there were no effects of dominant species removal on species richness or composition of the subdominant community. Total aboveground biomass was not affected by dominant species removal, suggesting that the community of subdominant species exhibited compensation. In fact, subdominant community biomass was greater when Solidago, but not Verbesina, was removed. Light availability was also greater in plots where Solidago was removed relative to control plots throughout the growing season. In addition, removal of dominant species, in particular Solidago, indirectly reduced the emergence, but not survival, of Lespedeza seedlings by directly promoting subdominant community biomass. Taken together, our results suggest that dominant old-field plant species affect subdominant community structure and indirectly promote establishment by Lespedeza.
C1 [Souza, Lara; Sanders, Nathan J.] Univ Tennessee, Dept Ecol & Evolutionary Biol, Knoxville, TN 37996 USA.
[Weltzin, Jake F.] USA, Natl Phenol Network, Natl Coordinating Off, Tucson, AZ 85719 USA.
RP Souza, L (reprint author), Univ Tennessee, Dept Ecol & Evolutionary Biol, 1416 Circle Dr, Knoxville, TN 37996 USA.
EM lsouza@utk.edu
RI Sanders, Nathan/A-6945-2009
OI Sanders, Nathan/0000-0001-6220-6731
FU Department of Ecology and Evolutionary Biology at the University of
Tennessee
FX The Department of Ecology and Evolutionary Biology at the University of
Tennessee (Summer Research Award to L.S.).
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1752-9921
J9 J PLANT ECOL-UK
JI J. Plant Ecol.
PD SEP
PY 2011
VL 4
IS 3
BP 123
EP 131
DI 10.1093/jpe/rtq027
PG 9
WC Plant Sciences; Ecology
SC Plant Sciences; Environmental Sciences & Ecology
GA 818HR
UT WOS:000294743100002
ER
PT J
AU Bianchini, A
Heitzman, M
Maghsoodloo, S
AF Bianchini, Alessandra
Heitzman, Michael
Maghsoodloo, Saeed
TI Evaluation of Temperature Influence on Friction Measurements
SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE
LA English
DT Article
DE Friction; Temperature influence; Correction factor
AB Many aspects influence the skid resistance of a pavement surface including surface texture, tire characteristics, vehicle operations, and environmental factors. The objective of this paper is to quantify the temperature influence on the skid number of asphalt pavement surfaces when measured by the locked-wheel friction tester. Specifically, this study aims to determine an adjustment factor for friction readings to a standard reference temperature, removing the seasonal temperature variations influencing measurements. This allows agencies to improve the comparison of pavement sections and to provide a more objective assessment of pavement conditions for safety. The friction database employed is from the National Center for Asphalt Technology Test Track facility. The data includes friction measurements with a locked-wheel trailer on sections from the 2000 and 2003 research cycles. The approach calculates the temperature adjustment factor, C(T), from a grouping of the data by temperature values at the time of the measurements. The results show that it is possible to define a reference temperature to adjust friction measured at any other temperature value. The reference temperature identified is between 19.5 degrees C (67.1 degrees F) and 20.2 degrees C (68.4 degrees F). The study concludes that when testing, if the air temperature is greater than the reference temperature, the friction reading is biased by a positive quantity. Therefore the adjustment factor, C(T), reduces the measured friction, whereas for measurements performed at temperatures lower than the reference temperature, C(T) increases the measured friction. DOI: 10.1061/(ASCE)TE.1943-5436.0000271. (C) 2011 American Society of Civil Engineers.
C1 [Bianchini, Alessandra] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Heitzman, Michael] Natl Ctr Asphalt Technol, Auburn, AL 36830 USA.
[Maghsoodloo, Saeed] Auburn Univ, Shelby Ctr 3301, Auburn, AL 36849 USA.
RP Bianchini, A (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM alessandra.bianchini@usace.army.mil; mah0016@auburn.edu;
maghssa@auburn.edu
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PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-947X
J9 J TRANSP ENG-ASCE
JI J. Transp. Eng.-ASCE
PD SEP
PY 2011
VL 137
IS 9
BP 640
EP 647
DI 10.1061/(ASCE)TE.1943-5436.0000271
PG 8
WC Engineering, Civil; Transportation Science & Technology
SC Engineering; Transportation
GA 818WI
UT WOS:000294786200005
ER
PT J
AU Bhandari, M
Guyatt, G
Jeray, K
Jeray, KJ
Petrisor, B
Schemitsch, E
Sancheti, P
Anglen, J
Tornetta, P
Bosse, M
Liew, S
Walter, S
Sun, X
Sprague, S
Mckay, P
Heels-Ansdell, D
Buckingham, L
Lacchetti, C
Leece, P
Ansell, N
Quigley, L
Vena, D
Mignott, T
Tanner, S
Altman, D
Ghandi, R
Bischoff, M
Westberry, DE
Broderick, JS
Goetz, DR
Beckish, ML
Tanner, SL
Gettys, FK
Drew, B
Gandhi, R
Mandel, S
Ogilvie, R
Mignott, T
Ansell, N
Pradhan, C
Puram, C
Patil, A
Rocha, S
Papp, S
Wai, EK
Liew, A
Gofton, W
Borsella, V
Vexler, L
Coles, C
Leighton, R
Amirault, D
Oxner, W
Alexander, D
Coady, C
Dunbar, M
Glazebrook, M
Gross, M
Johnston, D
Reardon, G
Stanish, W
Trask, K
Dobbin, G
Conflitti, JM
Devinney, DS
Howell, SG
Kreder, HJ
Stephen, DJG
Jenkinson, R
Richards, S
Bulmer, B
Crnko, N
Della Rocca, GJ
Crist, BD
Anderson, LK
Schemitsch, EH
McKee, MD
Hall, JA
Vicente, MR
Wild, LM
Khan, RM
Porter, SE
Snider, RG
Yarbrough, S
Crist, BD
Murtha, YM
Anderson, LK
Sullivan, KM
Marcantonio, AJ
Kain, MS
Wilk, RM
Iorio, R
Smiley, PM
Kasparyan, G
Baumfeld, JA
Tolo, ET
Hunter, AA
Soong, M
Lobo, M
Teebagy, AK
Thompson, MS
Tilzey, JF
Garfi, J
Mullis, B
Ertl, J
Anglen, JO
Parr, JA
Cummings, JE
Worman, R
Tobias, E
Prucinsky, C
Frizzell, V
Frizzell, S
Phieffer, L
Lakatos, R
Dimeo, T
Macalester, S
Zura, R
Manson, MJ
Prayson, M
McMahon, S
Coffey, M
Vourazeris, J
Miclau, T
Kandemir, U
Morshed, S
Belaye, T
Russell, G
Graves, M
Smith, L
Qin, Z
Hsu, JR
Wenke, JC
Lopez, DM
Collinge, C
Weaver, T
Zamorano, DP
Lawson, D
Smith, J
Whaba, G
Hofer, J
Steinhoff, A
Stewart, R
Goldstein, J
Waldrop, H
Nix, T
Williams, D
Wong, I
Rajaratnam, K
Kwok, D
Kuurstra, N
Kunz, M
Cagaanan, R
McCormack, R
Moola, F
Perey, B
Stone, T
Viskontas, D
Lemke, M
Boyer, D
Zomar, M
Moon, K
Reindl, R
Harvey, E
Berry, G
Talbot, M
Houghton, F
Leduc, S
Laflamme, GY
Rouleau, D
Gagnon, S
Malo, M
Benoit, B
Ranger, P
Fernandes, J
Beaumont, P
Poirier, MF
Fournier, J
O'Brien, PJ
Blachut, PA
Broekhuyse, HM
Guy, P
Lefaivre, K
Johal, R
Mutepfa, J
Sanders, D
Tieszer, C
Tufescu, T
Pilkey, B
Graham, C
Barron, L
Dubberly, J
Sultana, N
Russ, M
Dowrick, A
Balogh, Z
Evans, J
King, K
Yang, TF
Liu, Y
AF Bhandari, Mohit
Guyatt, Gordon
Jeray, Kyle
Jeray, Kyle J.
Petrisor, Bradley
Schemitsch, Emil
Sancheti, Parag
Anglen, Jeff
Tornetta, Paul
Bosse, Michael
Liew, Susan
Walter, Stephen
Sun, Xin
Sprague, Sheila
McKay, Paula
Heels-Ansdell, Diane
Buckingham, Lisa
Lacchetti, Christina
Leece, Pamela
Ansell, Natalie
Quigley, Laura
Vena, Daniel
Mignott, Tashay
Tanner, Stephanie
Altman, Doug
Ghandi, Rajiv
Bischoff, Markus
Westberry, David E.
Broderick, J. Scott
Goetz, David R.
Beckish, Michael L.
Tanner, Stephanie L.
Gettys, F. Keith
Drew, Brian
Gandhi, Rajiv
Mandel, Scott
Ogilvie, Rick
Mignott, Tashay
Ansell, Natalie
Pradhan, Chetan
Puram, Chetan
Patil, Atul
Rocha, Steve
Papp, Steven
Wai, Eugene K.
Liew, Allan
Gofton, Wade
Borsella, Vivian
Vexler, Liisa
Coles, Chad
Leighton, Ross
Amirault, David
Oxner, William
Alexander, David
Coady, Catherine
Dunbar, Michael
Glazebrook, Mark
Gross, Michael
Johnston, David
Reardon, Gerald
Stanish, William
Trask, Kelly
Dobbin, Gwendolyn
Conflitti, Joseph M.
Devinney, Dennis Scott
Howell, Susan G.
Kreder, Hans J.
Stephen, David J. G.
Jenkinson, Richard
Richards, Stacey
Bulmer, Bev
Crnko, Naomi
Della Rocca, Gregory J.
Crist, Brett D.
Anderson, Linda K.
Schemitsch, Emil H.
McKee, Michael D.
Hall, Jeremy A.
Vicente, Milena R.
Wild, Lisa M.
Khan, Ryan M.
Porter, Scott E.
Snider, Rebecca G.
Yarbrough, Stephanie
Crist, Brett D.
Murtha, Yvonne M.
Anderson, Linda K.
Sullivan, Kelly M.
Marcantonio, Andrew J.
Kain, Michael S.
Wilk, Richard M.
Iorio, Richard
Smiley, Paul M.
Kasparyan, George
Baumfeld, Joshua A.
Tolo, Eric T.
Hunter, Alice A.
Soong, Maximillian
Lobo, Margaret
Teebagy, Anthony K.
Thompson, Michael S.
Tilzey, John F.
Garfi, John
Mullis, Brian
Ertl, Janos
Anglen, Jeffrey O.
Parr, J. Andrew
Cummings, Judd E.
Worman, Ripley
Tobias, Erin
Prucinsky, Caitlyn
Frizzell, Valda
Frizzell, Sara
Phieffer, Laura
Lakatos, Ronald
Dimeo, Teresa
Macalester, Skye
Zura, Robert
Manson, Maria J.
Prayson, Michael
McMahon, Stacy
Coffey, Mike
Vourazeris, Jason
Miclau, Theodore
Kandemir, Utku
Morshed, Saam
Belaye, Tigist
Russell, George
Graves, Matt
Smith, Lori
Qin, Zhen
Hsu, Joseph R.
Wenke, Joseph C.
Lopez, Donna M.
Collinge, Cory
Weaver, Tara
Zamorano, David P.
Lawson, Deanna
Smith, Jeremy
Whaba, George
Hofer, Jason
Steinhoff, Amy
Stewart, Rena
Goldstein, Jessica
Waldrop, Holly
Nix, Tanya
Williams, Dale
Wong, Ivan
Rajaratnam, Krishan
Kwok, Desmond
Kuurstra, Natalie
Kunz, Monica
Cagaanan, Ria
McCormack, Robert
Moola, Farhad
Perey, Bertrand
Stone, Trevor
Viskontas, Darius
Lemke, Mike
Boyer, Dory
Zomar, Mauri
Moon, Karyn
Reindl, Rudy
Harvey, Edward
Berry, Greg
Talbot, Max
Houghton, Fiona
Leduc, Stephane
Laflamme, G. Yves
Rouleau, Dominique
Gagnon, Sylvain
Malo, Michel
Benoit, Benoit
Ranger, Pierre
Fernandes, Julio
Beaumont, Pierre
Poirier, Marie-France
Fournier, Julie
O'Brien, Peter J.
Blachut, Piotr A.
Broekhuyse, Henry M.
Guy, Pierre
Lefaivre, Kelly
Johal, Raman
Mutepfa, Josephine
Sanders, David
Tieszer, Christina
Tufescu, Ted
Pilkey, Brad
Graham, Chris
Barron, Laurie
Dubberly, Jamie
Sultana, Nigar
Russ, Matthias
Dowrick, Adam
Balogh, Zsolt
Evans, Julie
King, Kate
Yang, Tianfu
Liu, Yang
CA FLOW Investigators
TI Fluid Lavage of Open Wounds (FLOW): A Multicenter, Blinded, Factorial
Pilot Trial Comparing Alternative Irrigating Solutions and Pressures in
Patients With Open Fractures
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Open fractures; Irrigation solutions; Irrigation pressures; Randomized
control trial; Factorial design; Pilot study
ID PULSATILE LAVAGE; IN-VITRO; BONE; INFECTION; BACTERIA; EFFICACY; DELAY;
TIBIA; SHAFT; SOAP
AB Background: Open fractures are an important source of morbidity and are associated with delayed union, nonunion, and infection. Preventing infection through meticulous irrigation and debridement is an important goal in management, and different lavage fluids and irrigation techniques (e.g., high-or low-pressure lavage) have been described for this purpose. However, there are a limited number of randomized trials comparing irrigating solutions or irrigating technique. We compared the use of castile soap versus normal saline and high-versus low-pressure pulsatile lavage on the rates of reoperations and complications in patients with open fracture wounds.
Methods: We conducted a multicenter, blinded, randomized 2 x 2 factorial pilot trial of 111 patients in whom an open fracture wound was treated with either castile soap solution or normal saline and either high-or low-pressure pulsatile lavage. The primary composite outcome of reoperation, measured at 12 months after initial operative procedure, included infection, wound healing problems, and nonunion. Planned reoperations were not included. Secondary outcomes included all infection, all wound healing problems, and nonunion as well as functional outcomes scores (EuroQol-5 dimensions and short form-12).
Results: Eighty-nine patients completed the 1-year follow-up. Among all patients, 13 (23%) in the castile soap group and 13 (24%) in the saline group had a primary outcome event (hazard ratio, 0.91, 95% confidence interval: 0.42-2.00, p = 0.52). Sixteen patients (28%) in the high-pressure group and 10 patients (19%) in the low-pressure group had a primary outcome event (hazard ratio 0.55, 95% confidence interval: 0.24-1.27, p = 0.17). Functional outcome scores showed no significant differences at any time point between groups.
Conclusion: The fluid lavage of open wounds pilot randomized controlled trial demonstrated the possibility that the use of low pressure may decrease the reoperation rate for infection, wound healing problems, or nonunion. We have demonstrated the desirability and feasibility of a definitive trial examining the effects of alternative irrigation approaches.
C1 [Bhandari, Mohit; Guyatt, Gordon; Sun, Xin; Sprague, Sheila; McKay, Paula; Heels-Ansdell, Diane; Buckingham, Lisa; Lacchetti, Christina; Leece, Pamela; Ansell, Natalie; Quigley, Laura; Vena, Daniel; Mignott, Tashay] McMaster Univ, Hamilton, ON L8L 8E7, Canada.
[Jeray, Kyle J.; Broderick, J. Scott; Goetz, David R.; Beckish, Michael L.; Tanner, Stephanie L.; Gettys, F. Keith; Porter, Scott E.; Snider, Rebecca G.] Greenville Hosp Syst, Greenville, SC USA.
[Bhandari, Mohit; Petrisor, Bradley; Sprague, Sheila; McKay, Paula; Quigley, Laura; Mignott, Tashay; Ghandi, Rajiv; Drew, Brian; Gandhi, Rajiv; Mandel, Scott; Ogilvie, Rick; Mignott, Tashay; Ansell, Natalie; Williams, Dale; Wong, Ivan; Rajaratnam, Krishan; Kwok, Desmond; Kuurstra, Natalie] Hamilton Hlth Sci, Hamilton, ON, Canada.
[Papp, Steven; Wai, Eugene K.; Liew, Allan; Gofton, Wade; Borsella, Vivian; Vexler, Liisa] Ottawa Hosp Civ Campus, Ottawa, ON, Canada.
[Kreder, Hans J.; Stephen, David J. G.; Jenkinson, Richard; Richards, Stacey; Bulmer, Bev; Crnko, Naomi] Univ Toronto, Hlth Sci Ctr, Toronto, ON, Canada.
[Schemitsch, Emil H.; McKee, Michael D.; Hall, Jeremy A.; Vicente, Milena R.; Wild, Lisa M.; Khan, Ryan M.] Univ Toronto, St Michaels Hosp, Toronto, ON M5B 1W8, Canada.
[Marcantonio, Andrew J.; Kain, Michael S.; Wilk, Richard M.; Iorio, Richard; Smiley, Paul M.; Kasparyan, George; Baumfeld, Joshua A.; Tolo, Eric T.; Hunter, Alice A.; Soong, Maximillian; Lobo, Margaret; Teebagy, Anthony K.; Thompson, Michael S.; Tilzey, John F.; Garfi, John] Lahey Clin Med Ctr, Burlington, MA 01803 USA.
[Mullis, Brian; Ertl, Janos; Anglen, Jeffrey O.; Parr, J. Andrew; Cummings, Judd E.; Worman, Ripley; Tobias, Erin; Prucinsky, Caitlyn; Frizzell, Valda; Frizzell, Sara] Indiana Univ, Wishard Hlth Serv, Indianapolis, IN 46204 USA.
[Phieffer, Laura; Lakatos, Ronald; Dimeo, Teresa; Macalester, Skye] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA.
[Zura, Robert; Manson, Maria J.] Duke Univ, Med Ctr, Durham, NC USA.
[Prayson, Michael; McMahon, Stacy; Coffey, Mike; Vourazeris, Jason] Wright State Univ, Miami Valley Hosp, Dayton, OH 45435 USA.
[Miclau, Theodore; Kandemir, Utku; Morshed, Saam; Belaye, Tigist] San Francisco Gen Hosp, San Francisco, CA 94110 USA.
[Russell, George; Graves, Matt; Smith, Lori; Qin, Zhen] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA.
[Hsu, Joseph R.; Wenke, Joseph C.; Lopez, Donna M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Hsu, Joseph R.; Wenke, Joseph C.; Lopez, Donna M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Collinge, Cory; Weaver, Tara] Harris Methodist Hosp, Ft Worth, TX USA.
[Zamorano, David P.; Lawson, Deanna; Smith, Jeremy; Whaba, George; Hofer, Jason; Steinhoff, Amy] Univ Calif Irvine, Orange, CA 92668 USA.
[Stewart, Rena; Goldstein, Jessica; Waldrop, Holly; Nix, Tanya] Univ Alabama, Birmingham, AL USA.
[Kreder, Hans J.; Stephen, David J. G.; Jenkinson, Richard; Kunz, Monica; Cagaanan, Ria] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada.
[McCormack, Robert; Moola, Farhad; Perey, Bertrand; Stone, Trevor; Viskontas, Darius; Lemke, Mike; Boyer, Dory; Zomar, Mauri; Moon, Karyn] Royal Columbian Hosp, New Westminster, BC, Canada.
[Reindl, Rudy; Harvey, Edward; Berry, Greg; Talbot, Max; Houghton, Fiona] McGill Univ, Ctr Hlth, Montreal, PQ, Canada.
[Leduc, Stephane; Laflamme, G. Yves; Rouleau, Dominique; Gagnon, Sylvain; Malo, Michel; Benoit, Benoit; Ranger, Pierre; Fernandes, Julio; Beaumont, Pierre; Poirier, Marie-France; Fournier, Julie] Hop Sacre Coeur, Montreal, PQ H4J 1C5, Canada.
[O'Brien, Peter J.; Blachut, Piotr A.; Broekhuyse, Henry M.; Guy, Pierre; Lefaivre, Kelly; Johal, Raman; Mutepfa, Josephine] Vancouver Gen Hosp, Vancouver, BC, Canada.
[Sanders, David; Tieszer, Christina] London Hlth Sci Ctr, London, ON, Canada.
[Tufescu, Ted; Pilkey, Brad; Graham, Chris; Barron, Laurie; Dubberly, Jamie; Sultana, Nigar] Hlth Sci Ctr Winnipeg, Winnipeg, MB, Canada.
[Liew, Susan; Russ, Matthias; Dowrick, Adam] The Alfred, Melbourne, Vic, Australia.
[Balogh, Zsolt; Evans, Julie; King, Kate] John Hunter Hosp, Newcastle, NSW, Australia.
[Balogh, Zsolt; Evans, Julie; King, Kate] Hunter New England Area Hlth Serv, Newcastle, NSW, Australia.
[Yang, Tianfu; Liu, Yang] Sichuan Univ, W China Hosp, Chengdu, Peoples R China.
RP Bhandari, M (reprint author), McMaster Univ, 293 Wellington St N,Suite 110, Hamilton, ON L8L 8E7, Canada.
EM bhandam@mcmaster.ca
RI Balogh, Zsolt/A-2002-2010; Fernandes, Julio C/B-6916-2014;
OI Balogh, Zsolt/0000-0002-0277-4822; Fernandes, Julio
C/0000-0002-3888-832X; Soong, Maximillian/0000-0003-0333-8181
FU Physician Services Incorporated; National Natural Sciences Foundation of
China [70703025]; Orthopaedic Trauma Association; Surgical Associates;
Department of Surgery; McMaster University
FX Supported by the Physician Services Incorporated, the Orthopaedic Trauma
Association, and the Surgical Associates, Department of Surgery,
McMaster University research grants; and by the National Natural
Sciences Foundation of China research scholarship grant 70703025 ( to
X.S.).
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2011
VL 71
IS 3
BP 596
EP 606
DI 10.1097/TA.0b013e3181f6f2e8
PG 11
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 818MX
UT WOS:000294756900021
ER
PT J
AU Bowman, PD
Wang, XY
Meledeo, MA
Dubick, MA
Kheirabadi, BS
AF Bowman, Phillip D.
Wang, Xinyu
Meledeo, Michael A.
Dubick, Michael A.
Kheirabadi, Bijan S.
TI Toxicity of Aluminum Silicates Used in Hemostatic Dressings Toward Human
Umbilical Veins Endothelial Cells, HeLa Cells, and RAW267.4 Mouse
Macrophages
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Aluminum silicates; Hemostatic agents; Human endothelial cells; HeLa
cells; Mouse macrophage cells; Cytotoxicity
ID EXTREMITY ARTERIAL HEMORRHAGE; SWINE MODEL; SMECTITE GRANULES; AGENTS;
EFFICACY; INJURY; CLAY
AB Background: Aluminum silicates have been used to control bleeding after severe traumatic injury. QuikClot (QC) was the first such product, and WoundStat (WS) is the most recent. We recently observed that WS caused vascular thrombosis when applied to stop bleeding. This study investigated the cellular toxicity of WS in different cell types that may be exposed to this mineral and compared the results with other minerals such as bentonite, kaolin, and QuikClot ACS+ (QC +).
Methods: Human umbilical vein endothelial cells (HUVEC), HeLa cells, and RAW267.4 mouse macrophage-like cells (RAW) were incubated directly with different concentrations of each mineral for 24 hours. Cell viability was determined metabolically using the AlamarBlue fluorescent technique. In another experiment, minerals were exposed to HUVEC via Transwell inserts with a polycarbonate filter (0.4-mu m pore size) to prevent direct contact between cells and minerals for determining whether direct exposure or leaching compounds from minerals cause cytotoxicity.
Results: Incubation of HUVEC and RAW cells with 1 to 100 mu g/mL of the minerals for 24 hours resulted in differential toxicities. The cytotoxicity of WS was equal to that of bentonite and higher than kaolin and QC+. Neither cell type survived for 24 hours in the presence of 100 mu g/mL WS or bentonite. These minerals, however, had little effect on the viability of HeLa cells. In the second HUVEC experiment, a 10 times higher concentration of these compounds placed in Transwell inserts yielded no decrease in cell viability. This result indicates that leaching toxicants or binding of nutrients by the ion-exchange properties of minerals did not cause the toxicity.
Conclusions: Although aluminum silicates seem relatively innocuous to epithelial cells, all produced some toxicity toward endothelial cells and macrophages. WS and bentonite were significantly more toxic than kaolin and zeolite present in QC+, respectively, at equivalent doses. The cytotoxic effect seemed to be caused by the direct contact of the minerals with the cells present in wounds. These data suggest that the future clearance of mineral-based hemostatic agents should require more extensive cytotoxicity testing than the current Food and Drug Administration requirements.
C1 [Bowman, Phillip D.; Wang, Xinyu; Meledeo, Michael A.; Dubick, Michael A.; Kheirabadi, Bijan S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Wang, Xinyu] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA.
RP Kheirabadi, BS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM bijan.kheirabadi@amedd.amry.mil
OI Meledeo, Michael/0000-0001-9958-9115
FU US Army Medical Research and Materiel Command
FX Supported by the US Army Medical Research and Materiel Command.
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U1 1
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2011
VL 71
IS 3
BP 727
EP 732
DI 10.1097/TA.0b013e3182033579
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 818MX
UT WOS:000294756900041
PM 21768911
ER
PT J
AU Webster, MR
De Vita, R
Twigg, JN
Socha, JJ
AF Webster, Matthew R.
De Vita, Raffaella
Twigg, Jeffrey N.
Socha, John J.
TI Mechanical properties of tracheal tubes in the American cockroach
(Periplaneta americana)
SO SMART MATERIALS AND STRUCTURES
LA English
DT Article; Proceedings Paper
CT 3rd Annual Meeting of the ASME/AIAA Smart Materials, Adaptive
Structures, and Intelligent Systems (SMASIS)/Symposium on Modeling,
Simulation and Control
CY SEP 28-OCT 01, 2010
CL Philadelphia, PA
SP ASME, Nanotechnol Inst, AIAA
ID INSECT; DIFFUSION; CUTICLE; RESPIRATION; BEETLE; SYSTEM
AB Insects breathe using an extensive network of flexible air-filled tubes. In some species, the rapid collapse and reinflation of these tubes is used to drive convective airflow, a system that may have bio-inspired engineering applications. The mechanical behavior of these tracheal tubes is critical to understanding how they function in this deformation process. Here, we performed quasi-static tensile tests on ring sections of the main thoracic tracheal trunks from the American cockroach (Periplaneta americana) to determine the tracheal mechanical properties in the radial direction. The experimental findings indicate that the stress-strain relationships of these tracheal tubes exhibit some nonlinearities. The elastic modulus of the linear region of the stress-strain curves tubes was found to be 1660 +/- 512 MPa. The ultimate tensile strength, ultimate strain and toughness were found to be 23.7 +/- 7.33 MPa, 2.0 +/- 0.7% and 0.207 +/- 0.153 MJ m(-3), respectively. This study is the first experimental quantification of insect tracheal tissue, and represents a necessary step toward understanding the mechanical role of tracheal tubes in insect respiration.
C1 [Webster, Matthew R.; De Vita, Raffaella] Virginia Tech, Dept Engn Sci & Mech, Mech Soft Biol Syst Lab, Blacksburg, VA 24061 USA.
[Twigg, Jeffrey N.] Army Res Lab, Adelphi, MD 20783 USA.
RP Webster, MR (reprint author), Virginia Tech, Dept Engn Sci & Mech, Mech Soft Biol Syst Lab, Blacksburg, VA 24061 USA.
EM mwbstr@vt.edu; devita@vt.edu; jeffrey.n.twigg@us.army.mil;
jjsocha@vt.edu
RI De Vita, Raffaella/A-3292-2012
NR 24
TC 5
Z9 5
U1 0
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0964-1726
EI 1361-665X
J9 SMART MATER STRUCT
JI Smart Mater. Struct.
PD SEP
PY 2011
VL 20
IS 9
SI SI
AR 094017
DI 10.1088/0964-1726/20/9/094017
PG 7
WC Instruments & Instrumentation; Materials Science, Multidisciplinary
SC Instruments & Instrumentation; Materials Science
GA 818RQ
UT WOS:000294773100018
ER
PT J
AU Ko, S
Kim, HC
Yang, YC
Chong, ST
Richards, AL
Sames, WJ
Klein, TA
Kang, JG
Chae, JS
AF Ko, Sungjin
Kim, Heung-Chul
Yang, Young-Cheol
Chong, Sung-Tae
Richards, Allen L.
Sames, William J.
Klein, Terry A.
Kang, Jun-Gu
Chae, Joon-Seok
TI Detection of Rickettsia felis and Rickettsia typhi and Seasonal
Prevalence of Fleas Collected from Small Mammals at Gyeonggi Province in
the Republic of Korea
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Ctenophthalmus congeneroides, Stenoponia sidimi; Flea; Korea; Rickettsia
felis; Rickettsia typhi
ID SPOTTED-FEVER GROUP; SCRUB TYPHUS; MURINE TYPHUS; SEROLOGICAL
SURVEILLANCE; SOUTH-KOREA; CAT FLEAS; BORNE; INFECTION; TICKS;
IDENTIFICATION
AB Fleas were collected from live-captured small mammals to identify flea-borne pathogens, host associations, and seasonal prevalence of flea species, as part of the 65th Medical Brigade rodent-borne disease surveillance program at 20 military installations and training sites, Gyeonggi Province, Republic of Korea, 2005-2007. A total of 1251 fleas were recovered from 2833 small mammals. Apodemus agrarius, the striped field mouse, accounted for 93.1% (2,637/2,833) of all small mammals captured, followed by Crocidura lasiura (3.1%), Mus musculus (1.3%), Microtus fortis (0.7%), Myodes regulus (0.7%), Micromys minutus (0.5%), Rattus norvegicus (0.4%), Tscherskia triton (0.1%), Apodemus peninsulae (<0.1%), Rattus rattus (<0.1%), and Mogera robusta (<0.1%). A total of 6/11 species of mammals captured were infested with fleas with infestation rates ranging from a high of 26.3% (A. agrarius and M. regulus) to a low of 5.3% (M. fortis). Flea indices among infested mammals were highest for R. norvegicus (2.50), followed by C. lasiura (2.20), A. agrarius (1.71), M. regulus (1.20), M. musculus (1.0), and M. fortis (1.0). The predominant flea species collected were Stenoponia sidimi (56.5%), followed by Ctenophthalmus congeneroides (38.3%) and Rhadinopsylla insolita (3.9%). The minimum field infection rates [ number of positive pools/total number of fleas (600)] for Rickettsia typhi and for Rickettsia felis were 1.7% and 1.0%, respectively.
C1 [Ko, Sungjin; Kang, Jun-Gu; Chae, Joon-Seok] Seoul Natl Univ, Coll Vet Med, Dept Vet Internal Med, Res Inst, Seoul 151742, South Korea.
[Ko, Sungjin; Kang, Jun-Gu; Chae, Joon-Seok] Seoul Natl Univ, Program Vet Sci BK21, Seoul 151742, South Korea.
[Kim, Heung-Chul; Chong, Sung-Tae] 168th Multifunct Med Battal, Med Detachment 5, APO, AP 96205 USA.
[Yang, Young-Cheol] Eulji Univ, Dept Environm Hlth, Songnam, South Korea.
[Richards, Allen L.] USN, Viral & Rickettsial Dis Dept, Med Res Ctr, Silver Spring, MD USA.
[Sames, William J.] Walter Reed Army Med Ctr, OD AFPMB, Washington, DC 20307 USA.
[Klein, Terry A.] US Army MEDDAC Korea, Force Hlth Protect & Prevent Med, APO, AP 96205 USA.
RP Chae, JS (reprint author), Seoul Natl Univ, Coll Vet Med, Dept Vet Internal Med, Res Inst, Seoul 151742, South Korea.
EM jschae@snu.ac.kr
RI Valle, Ruben/A-7512-2013
FU Armed Forces Health Surveillance Center; Global Emerging Infections
Surveillance and Response System, Silver Spring, MD; Seoul National
University, Seoul, Korea
FX We thank the commanders and personnel of the 5th and 38th Medical
Detachments, 168th Multifunctional Medical Battalion, for their support
in conducting small mammal surveillance. We especially thank Dr. Joel
Gaydos, Global Emerging Infections Surveillance and Response System,
Silver Spring, MD, for his support and constructive criticism. Funding
for portions of this work was provided by the Armed Forces Health
Surveillance Center, Global Emerging Infections Surveillance and
Response System, Silver Spring, MD, the National Center for Military
Intelligence, Ft. Detrick, MD, and through the BK21 Program for
Veterinary Science, Seoul National University, Seoul, Korea.
NR 38
TC 6
Z9 7
U1 1
U2 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD SEP
PY 2011
VL 11
IS 9
BP 1243
EP 1251
DI 10.1089/vbz.2010.0261
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 818QQ
UT WOS:000294769900003
PM 21612536
ER
PT J
AU Owens, BD
Harrast, JJ
Hurwitz, SR
Thompson, TL
Wolf, JM
AF Owens, Brett D.
Harrast, John J.
Hurwitz, Shepard R.
Thompson, Terry L.
Wolf, Jennifer Moriatis
TI Surgical Trends in Bankart Repair An Analysis of Data From the American
Board of Orthopaedic Surgery Certification Examination
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE arthroscopy; Bankart; instability; trend; complication
ID ANTERIOR SHOULDER INSTABILITY; STABILIZATION; PART
AB Background: Arthroscopic Bankart repair emerged in the 1990s as a minimally invasive alternative to open repair. The optimal technique of surgical stabilization of the unstable glenohumeral joint remains controversial.
Hypothesis: A review of the American Board of Orthopaedic Surgery (ABOS) data would show a trend toward an increasing number of arthroscopic versus open Bankart procedures.
Study Design: Descriptive epidemiology study.
Methods: A query of the ABOS database for all cases of open or arthroscopic Bankart repair from 2003 through 2008 was performed, as the CPT (Current Procedural Terminology) codes for arthroscopic repair were introduced in 2003. All cases coded with CPT codes for arthroscopic Bankart repair (29806) or open Bankart repair (23455) were reviewed. Additional data were obtained on the surgeons (year of procedure, geographic location, fellowship training, subspecialty examination area) as well as the patients (age, gender, follow-up length, complications, objective outcome measures [pain, deformity, function, and satisfaction]).
Results: From 2003 to 2008, a total of 4562 Bankart repair cases were reported, composing 8.6% of the total number of shoulder surgery cases in the ABOS database. From 2003 to 2005, 71.2% of Bankart repairs were arthroscopic, compared with 87.7% between 2006 and 2008 (P < .0001). Surgeons having obtained subspecialty training in sports medicine performed the majority (65.3%) of Bankart repairs. Over the entire period, sports-trained surgeons also performed a higher proportion of arthroscopic repairs (84.1%) compared with surgeons without this training (71.9%) (P < .0001). However, by 2008 both non-fellowship-trained and sports medicine fellowship-trained surgeons performed arthroscopic repair in 90% of cases. Surgeons in the Northeast region performed a significantly greater proportion of arthroscopic Bankart repairs (84.7%) than did surgeons in other regions (78.6%) (P < .0001) from 2003 to 2008. The most commonly reported complications were nerve palsy/injury and dislocation, with a rate of nerve injury of 2.2% in the open group compared to 0.3% in the arthroscopic group (P < .0001), and dislocation rate of 1.2% with open stabilization compared with 0.4% arthroscopically (P = .0039).
Conclusion: Review of the ABOS data shows a trend toward arthroscopic shoulder stabilization over time, with the use of open repair declining. Reported complications were lower overall in the arthroscopic stabilization group when compared with open surgeries.
C1 [Owens, Brett D.; Harrast, John J.; Hurwitz, Shepard R.; Thompson, Terry L.; Wolf, Jennifer Moriatis] Keller Army Hosp, West Point, NY 10996 USA.
RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA.
EM b.owens@us.army.mil
NR 12
TC 35
Z9 35
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD SEP
PY 2011
VL 39
IS 9
BP 1865
EP 1869
DI 10.1177/0363546511406869
PG 5
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 814VT
UT WOS:000294486000005
PM 21628637
ER
PT J
AU Stoyanovsky, DA
Maeda, A
Atkins, JL
Kagan, VE
AF Stoyanovsky, Detcho A.
Maeda, Akihiro
Atkins, James L.
Kagan, Valerian E.
TI Assessments of Thiyl Radicals in Biosystems: Difficulties and New
Applications
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID SPIN-TRAP; HYDROGEN-PEROXIDE; PROTEIN RADICALS; S-NITROSYLATION;
ASCORBIC-ACID; MODEL SYSTEMS; OXIDATION; DISULFIDES; TOXICITY; CYSTEINE
C1 [Stoyanovsky, Detcho A.; Maeda, Akihiro; Kagan, Valerian E.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15213 USA.
[Stoyanovsky, Detcho A.; Maeda, Akihiro; Kagan, Valerian E.] Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15213 USA.
[Atkins, James L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Stoyanovsky, DA (reprint author), Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15213 USA.
EM stoyanovskyd@upmc.edu; kagan@pitt.edu
OI Stoyanovsky, Detcho/0000-0001-5591-4780
FU NIH [U19A1068021]; Office of Naval Research [42237]
FX This work is supported by NIH grant U19A1068021 and by a grant from the
Office of Naval Research #42237. Disclaimer: The views, opinions, and/or
findings contained herein are those of the authors and should not be
construed as an official position, policy, or decision of the Department
of the Army, the Department of the Navy, or the Department of Defense.
NR 50
TC 10
Z9 10
U1 1
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD SEP 1
PY 2011
VL 83
IS 17
BP 6432
EP 6438
DI 10.1021/ac200418s
PG 7
WC Chemistry, Analytical
SC Chemistry
GA 812VX
UT WOS:000294322100002
PM 21591751
ER
PT J
AU Mann, EA
Wood, GL
Wade, CE
AF Mann, Elizabeth A.
Wood, Geri L.
Wade, Charles E.
TI Use of procalcitonin for the detection of sepsis in the critically ill
burn patient: A systematic review of the literature (vol 37, pg 549,
2011)
SO BURNS
LA English
DT Correction
C1 [Mann, Elizabeth A.] USA, Burn Ctr, Inst Surg Res, San Antonio, TX USA.
[Wood, Geri L.] Univ Texas Hlth Sci Ctr, Sch Nursing, Houston, TX USA.
[Wood, Geri L.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
RP Mann, EA (reprint author), USA, Burn Ctr, Inst Surg Res, San Antonio, TX USA.
EM elizabeth.mann@amedd.army.mil
NR 1
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD SEP
PY 2011
VL 37
IS 6
BP 1085
EP 1085
DI 10.1016/j.burns.2011.06.001
PG 1
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 815GA
UT WOS:000294512900030
ER
PT J
AU Norin, JA
Emanuel, DC
Letowski, TR
AF Norin, Julie A.
Emanuel, Diana C.
Letowski, Tomasz R.
TI Speech Intelligibility and Passive, Level-Dependent Earplugs
SO EAR AND HEARING
LA English
DT Article
ID HEARING PROTECTION DEVICES; SIGNAL-DETECTION; AUDITORY LOCALIZATION;
INDUSTRIAL NOISE; EAR-MUFFS; COMMUNICATION; RECOGNITION; PERCEPTION;
ABILITY
AB Objectives: Noise-induced hearing loss is one of the most common occupational diseases. Military personnel are at especially high risk due to the broad range of military noise hazards and the frequency of exposure. Hearing protectors are vital for this particular workforce, yet they can impede the ability to understand necessary communication in the field. Level-dependent hearing protectors are designed to protect the auditory system from the hazards of impulse noise, while preserving the ability to hear speech and other important auditory signals. The aim of this study was to evaluate the effect of two different passive, level-dependent earplugs (Combat Arms Earplugs; Sonic II Ear valves) on speech understanding of normal-hearing listeners in the presence of low-level background noise. The Combat Arms Earplug, developed specifically for use by military personnel, represented devices that attenuate impulse noise using small orifices and the Sonic II ear valve represented devices using an internal diaphragm.
Design: This study used a repeated-measures experimental design. Four scrambled lists of each of the four Northwestern University No. 6 50-word lists were presented in random order at 65 dB SPL in the presence of quiet and two different types of background noise: multitalker and military vehicle noise; using three ear conditions: NP (open ear), CA (Combat Arms Earplugs), and SO (Sonic II earplugs); and three signal-to-noise ratios (SNRs): -10, 0, and +10 dB. Word recognition scores (WRSs) of 18 native English-speaking adults with normal hearing sensitivity were measured in all test conditions. The percentage of words correctly repeated was used to determine differences between the two different level-dependent devices, types of background noise, and SNRs.
Results: Results showed a statistically significant increase in WRS as SNR increased from -10 to +10 dB. A repeated-measures analysis of variance for ear condition x noise x SNR indicated a significant main effect for SNR but not for type of noise or ear condition. A slight but significant interaction was found for SNR and ear condition.
Conclusions: SNR had great impact on the ability of listeners to understand speech in the presence of background noise; however, the type of noise and the type of level-dependent device used did not. The results of the study support the notion that individuals potentially subjected to high-level impulse noise should be able to use level-dependent earplugs in low-level continuous noise without compromising speech understanding. More specifically, the passive, level-dependent earplugs currently used by military personnel do not appear to be detrimental to speech communication for listeners with normal hearing when the speech is at an average conversational level and the listener is actively attending to the signal.
C1 [Norin, Julie A.] Hearing & Speech Agcy, Baltimore, MD 21215 USA.
[Emanuel, Diana C.] Towson Univ, Towson, MD USA.
[Letowski, Tomasz R.] USA, Res Lab, Aberdeen, MD USA.
RP Norin, JA (reprint author), Hearing & Speech Agcy, 5900 Metro Dr, Baltimore, MD 21215 USA.
EM jnorin@hasa.org
NR 47
TC 2
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-0202
J9 EAR HEARING
JI Ear Hear.
PD SEP-OCT
PY 2011
VL 32
IS 5
BP 642
EP 649
DI 10.1097/AUD.0b013e31821478c8
PG 8
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA 812HI
UT WOS:000294281400012
PM 21407078
ER
PT J
AU Csokmay, JM
Hill, MJ
Chason, RJ
Hennessy, S
James, AN
Cohen, J
DeCherney, AH
Segars, JH
Payson, MD
AF Csokmay, John M.
Hill, Micah J.
Chason, Rebecca J.
Hennessy, Sasha
James, Aidita N.
Cohen, Jacques
DeCherney, Alan H.
Segars, James H.
Payson, Mark D.
TI Experience with a patient-friendly, mandatory, single-blastocyst
transfer policy: the power of one
SO FERTILITY AND STERILITY
LA English
DT Article
DE ART; blastocyst; clinical pregnancy; implantation; infertility; IVF;
mandatory; multiple gestation; single
ID IN-VITRO FERTILIZATION; PREGNANCY RATES; EMBRYO-TRANSFER;
MULTIPLE-BIRTH; LIVE-BIRTH; METAANALYSIS; IVF
AB Objective: To determine whether a mandatory single-blastocyst transfer (mSBT) algorithm reduced multiple gestation rates without sacrificing clinical pregnancy rates.
Design: Retrospective review.
Setting: U.S. university-based assisted reproductive technology (ART) program.
Patient(s): All women younger than 38 years undergoing their first ART cycle from 2009 to 2010 with >= 4 high-grade embryos on day 3 after oocyte retrieval (patients from 2009 were the "before'' group, and patients completing ART under the mSBT policy in 2010 were the "after'' group).
Intervention(s): mSBT algorithm.
Main Outcome Measure(s): Multiple gestation and clinical pregnancy rates.
Result(s): Of the qualified patients, 136 women met inclusion criteria (62 from 2009, 74 from 2010). The baseline demographics were similar between the groups. Statistically significantly fewer blastocysts were transferred per patient in 2010 compared with 2009 (1.5 vs. 1.9). The clinical pregnancy rates before (67.7%) or after (63.5%) the mSBT policy were not statistically significantly different. Multiple gestation rates were statistically significantly reduced, from 43.8% (2009) to 14.6% (2010) after the mSBT policy was instituted. More patients from 2010 had >= 1 blastocyst cryopreserved compared with 2009 (52.9% vs. 30.6%).
Conclusion(s): A novel single-blastocyst transfer algorithm reduced multiple gestation rates and improved cryopreservation rates without compromising clinical pregnancy rates in good-prognosis patients. (Fertil Steril (R) 2011;96:580-4. (C) 2011 by American Society for Reproductive Medicine.)
C1 [Csokmay, John M.; Hill, Micah J.; Chason, Rebecca J.; Segars, James H.; Payson, Mark D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Csokmay, John M.; Hill, Micah J.; Chason, Rebecca J.; DeCherney, Alan H.; Segars, James H.] NICHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
[Hennessy, Sasha; James, Aidita N.] Washington Inc, ART Inst, Washington, DC USA.
[Cohen, Jacques] Reprogenetics, Livingston, NJ USA.
RP Csokmay, JM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM csokmayj@mail.nih.gov
FU NICHD, National Institutes of Health
FX Supported in part by the Intramural Research Program in Reproductive and
Adult Endocrinology, NICHD, National Institutes of Health. The views
expressed in this manuscript are those of the authors and do not reflect
the official policy or position of the Department of the Army,
Department of Defense, or the U.S. Government.
NR 11
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U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
BP 580
EP 584
DI 10.1016/j.fertnstert.2011.06.043
PG 5
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814BC
UT WOS:000294417000023
PM 21774925
ER
PT J
AU Beall, SA
Levy, G
Maguire, M
Stegmann, B
Payson, M
Segars, J
AF Beall, S. A.
Levy, G.
Maguire, M.
Stegmann, B.
Payson, M.
Segars, J.
TI BODY MASS INDEX (BMI) DOES NOT IMPACT NUMBER OF OOCYTES RETRIEVED OR
OOCYTE MATURATION IN WOMEN UNDERGOING ART
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 15-19, 2011
CL Orlando, FL
SP Amer Soc Reprod Med
C1 NICHHD, Program Reprod & Adult Endocrinol, Bethesda, MD 20892 USA.
Walter Reed Army Med Ctr, Dept Reprod Endocrinol & Infertil, Washington, DC 20307 USA.
Univ Iowa Hosp & Clin, Dept Reprod Endocrinol & Infertil, Iowa City, IA 52242 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
SU 1
BP S81
EP S82
PG 2
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814KZ
UT WOS:000294452700276
ER
PT J
AU Hill, MJ
Csokmay, JM
Chason, R
Hennessy, S
Segars, JH
Payson, MD
AF Hill, M. J.
Csokmay, J. M.
Chason, R.
Hennessy, S.
Segars, J. H.
Payson, M. D.
TI EXPERIENCE WITH A PATIENT FRIENDLY, MANDATORY SINGLE HIGH GRADE
BLASTOCYST TRANSFER POLICY: THE POWER OF ONE
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 15-19, 2011
CL Orlando, FL
SP Amer Soc Reprod Med
C1 Walter Reed Army Med Ctr, IVF, Washington, DC 20307 USA.
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
SU 1
BP S271
EP S271
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814KZ
UT WOS:000294452701156
ER
PT J
AU Hill, MJ
Csokmay, JM
Levy, G
DeCherney, AH
Levens, ED
AF Hill, M. J.
Csokmay, J. M.
Levy, G.
DeCherney, A. H.
Levens, E. D.
TI THE EFFECT OF EXOGENOUS LUTEINIZING HORMONE ADMINISTRATION DURING IVF
STIMULATION IN PATIENTS OF ADVANCE REPRODUCTIVE AGE
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 15-19, 2011
CL Orlando, FL
SP Amer Soc Reprod Med
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, Bethesda, MD USA.
Walter Reed Army Med Ctr, OBGYN, Washington, DC 20307 USA.
Shady Grove Fertil, Annandale, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
SU 1
BP S253
EP S253
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814KZ
UT WOS:000294452701099
ER
PT J
AU Levy, G
Beall, S
Alford, C
Propst, AM
AF Levy, G.
Beall, S.
Alford, C.
Propst, A. M.
TI DOES A FALL IN SERUM ESTRADIOL LEVELS AFTER HCG ADMINISTRATION CORRELATE
WITH LOWER PREGNANCY RATES IN PATIENTS UNDERGOING FRESH ART CYCLES?
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 15-19, 2011
CL Orlando, FL
SP Amer Soc Reprod Med
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Adult & Reprod Endocrinol, NIH, Bethesda, MD USA.
Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
SU 1
BP S193
EP S194
PG 2
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814KZ
UT WOS:000294452700661
ER
PT J
AU Yu, B
Parker, C
Merino, M
Hill, M
Armstrong, A
AF Yu, B.
Parker, C.
Merino, M.
Hill, M.
Armstrong, A.
TI NORMAL PUBERTY IS NOT EQUAL TO NORMAL GONADAL FUNCTION IN MALE AND
FEMALE CHILDHOOD CANCER SURVIVORS
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 15-19, 2011
CL Orlando, FL
SP Amer Soc Reprod Med
C1 NICHD, Program Adult & Reprod Endocrinol, NIH, Bethesda, MD USA.
Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2011
VL 96
IS 3
SU 1
BP S78
EP S78
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 814KZ
UT WOS:000294452700266
ER
PT J
AU Li, J
Sadler, BM
Viberg, M
AF Li, Jian
Sadler, Brian M.
Viberg, Mats
TI Sensor Array and Multichannel Signal Processing
SO IEEE SIGNAL PROCESSING MAGAZINE
LA English
DT Editorial Material
ID MIMO RADAR; ANTENNAS
C1 [Li, Jian] Univ Florida, Gainesville, FL 32611 USA.
[Sadler, Brian M.] USA, Res Lab, Washington, DC USA.
[Viberg, Mats] Chalmers, Gothenburg, Sweden.
RP Li, J (reprint author), Univ Florida, Gainesville, FL 32611 USA.
EM li@dsp.ufl.edu; brian.sadler@us.army.mil; mats.viberg@chalmers.se
RI Magazine, Signal Processing/E-9947-2015; Viberg, Mats/B-6505-2016
OI Viberg, Mats/0000-0003-1549-419X
NR 8
TC 2
Z9 2
U1 0
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1053-5888
J9 IEEE SIGNAL PROC MAG
JI IEEE Signal Process. Mag.
PD SEP
PY 2011
VL 28
IS 5
BP 157
EP 158
DI 10.1109/MSP.2011.941988
PG 2
WC Engineering, Electrical & Electronic
SC Engineering
GA 815QL
UT WOS:000294541200019
ER
PT J
AU Mancuso, JD
Niebuhr, DW
Frick, KD
Keep, LW
Anderson, KM
AF Mancuso, J. D.
Niebuhr, D. W.
Frick, K. D.
Keep, L. W.
Anderson, K. M.
TI Cost-effectiveness analysis of targeted and sequential screening
strategies for latent tuberculosis
SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
LA English
DT Article
DE tuberculosis screening; cost-effectiveness analysis; recruit medicine
ID GAMMA RELEASE ASSAYS; UNITED-STATES-NAVY; SKIN-TEST; US-ARMY; INFECTION;
COUNTRIES; HEALTH; ADULTS
AB SETTING: No cost-effectiveness studies of testing for latent tuberculosis infection have incorporated both targeted testing and the use of interferon-gamma release assays (IGRAs) in heterogeneous populations.
OBJECTIVE: To examine the cost-effectiveness of universal vs. targeted and sequential testing strategies and the use of tuberculin skin testing (TST) vs. IGRAs.
DESIGN: Using a decision-analytic model, incremental cost-effectiveness ratios were calculated in 2009 among nine potential strategies for screening recruits. A societal perspective was taken over a 20-year analytic horizon, discounting future costs at 3% annually. Sensitivity analyses were conducted to determine how changes in assumptions affected the estimates.
RESULTS: Targeted strategies cost over US$250000 per case prevented, whereas universal testing strategies cost over US$700000 per incremental case prevented in base case and most sensitivity analyses.
CONCLUSION: Targeted testing offered the best value in this population, although it was still relatively expensive compared to no testing. Sequential testing with both TST and IGRAs provided a poor incremental value compared to targeted and universal testing strategies. Targeted testing using TST was slightly more cost-effective than targeted testing using either QuantiFERON (R)-TB Gold In-Tube or T-SPOT (R).TB, but these estimates were very sensitive to changes in model assumptions.
C1 [Mancuso, J. D.] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA.
[Mancuso, J. D.; Keep, L. W.; Anderson, K. M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Frick, K. D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
EM james.mancuso@us.army.mil
NR 30
TC 8
Z9 8
U1 0
U2 0
PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
PI PARIS
PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
SN 1027-3719
EI 1815-7920
J9 INT J TUBERC LUNG D
JI Int. J. Tuberc. Lung Dis.
PD SEP
PY 2011
VL 15
IS 9
BP 1223
EP 1230
DI 10.5588/ijtld.10.0542
PG 8
WC Infectious Diseases; Respiratory System
SC Infectious Diseases; Respiratory System
GA 815JC
UT WOS:000294520900017
PM 21943850
ER
PT J
AU Thompson, WR
Majid, AS
Czymmek, KJ
Ruff, AL
Garcia, J
Duncan, RL
Farach-Carson, MC
AF Thompson, William R.
Majid, Amber S.
Czymmek, Kirk J.
Ruff, Albert L.
Garcia, Jesus
Duncan, Randall L.
Farach-Carson, Mary C.
TI Association of the alpha(2)delta(1) Subunit With Ca(v)3.2 Enhances
Membrane Expression and Regulates Mechanically Induced ATP Release in
MLO-Y4 Osteocytes
SO JOURNAL OF BONE AND MINERAL RESEARCH
LA English
DT Article
DE OSTEOCYTE; MECHANOSENSING; VOLTAGE-SENSITIVE CALCIUM CHANNEL;
EXTRACELLULAR MATRIX; ATP RELEASE
ID SENSITIVE CALCIUM-CHANNEL; INDUCED BONE-FORMATION; OSTEOBLASTIC CELLS;
CA2+ CHANNELS; BETA-SUBUNIT; FLUID SHEAR; MC3T3-E1 OSTEOBLASTS;
MESSENGER-RNA; GAMMA-SUBUNIT; MOUSE
AB Voltage-sensitive calcium channels (VSCCs) mediate signaling events in bone cells in response to mechanical loading. Osteoblasts predominantly express L-type VSCCs composed of the alpha(1) pore-forming subunit and several auxiliary subunits. Osteocytes, in contrast, express T-type VSCCs and a relatively small amount of L-type alpha(1) subunits. Auxiliary VSCC subunits have several functions, including modulating gating kinetics, trafficking of the channel, and phosphorylation events. The influence of the alpha(2)delta auxiliary subunit on T-type VSCCs and the physiologic consequences of that association are incompletely understood and have yet to be investigated in bone. In this study we postulated that the auxiliary alpha(2)delta subunit of the VSCC complex modulates mechanically regulated ATP release in osteocytes via its association with the T-type Ca(v)3.2 (alpha(1H)) subunit. We demonstrated by reverse-transcriptase polymerase chain reaction, Western blotting, and immunostaining that MLO-Y4 osteocyte-like cells express the T-type Ca(v)3.2 (alpha(1H)) subunit more abundantly than the L-type Ca(v)1.2 (alpha(1C)) subunit. We also demonstrated that the alpha(2)delta(1) subunit, previously described as an L-type auxiliary subunit, complexes with the T-type Ca(v)3.2 (alpha(1H)) subunit in MLO-Y4 cells. Interestingly, siRNA-mediated knockdown of alpha(2)delta(1) completely abrogated ATP release in response to membrane stretch in MLO-Y4 cells. Additionally, knockdown of the alpha(2)delta(1) subunit resulted in reduced ERK1/2 activation. Together these data demonstrate a functional VSCC complex. Immunocytochemistry following alpha(2)delta(1) knockdown showed decreased membrane localization of Ca(v)3.2 (alpha(1H)) at the plasma membrane, suggesting that the diminished ATP release and ERK1/2 activation in response to membrane stretch resulted from a lack of Ca(v)3.2 (alpha(1H)) at the cell membrane. (C) 2011 American Society for Bone and Mineral Research.
C1 [Thompson, William R.; Majid, Amber S.; Czymmek, Kirk J.; Duncan, Randall L.; Farach-Carson, Mary C.] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA.
[Thompson, William R.; Duncan, Randall L.] Univ Delaware, Biomech & Movement Sci Program, Newark, DE 19716 USA.
[Ruff, Albert L.] USA, Med Res Inst Chem Def, Cell & Mol Biol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Garcia, Jesus] Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60680 USA.
[Farach-Carson, Mary C.] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77251 USA.
RP Thompson, WR (reprint author), Univ Delaware, Dept Biol Sci, 317 Wolf Hall,105 Green, Newark, DE 19716 USA.
EM wthomp@udel.edu
FU Foundation for Physical Therapy Florence Kendall Scholarship; Foundation
for Physical Therapy Promotion of Doctoral Studies II; American Physical
Therapy Association Section on Geriatrics; Muscular Dystrophy
Association; [NIH T32 HD07490]; [NIH R01AR054385]; [NIH P20 RR016458]
FX This study was supported by the NIH T32 HD07490, NIH R01AR054385, NIH
P20 RR016458, a Foundation for Physical Therapy Florence Kendall
Scholarship, a Foundation for Physical Therapy Promotion of Doctoral
Studies II training fellowship, the American Physical Therapy
Association Section on Geriatrics Adopt-A-Doc Scholarship to WRT, and
the Muscular Dystrophy Association to JG.
NR 54
TC 28
Z9 30
U1 1
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0884-0431
J9 J BONE MINER RES
JI J. Bone Miner. Res.
PD SEP
PY 2011
VL 26
IS 9
BP 2125
EP 2139
DI 10.1002/jbmr.437
PG 15
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 814JG
UT WOS:000294444300013
PM 21638318
ER
PT J
AU Houston, JR
Dean, RG
AF Houston, J. R.
Dean, R. G.
TI Accounting for the Nodal Tide to Improve Estimates of Sea Level
Acceleration
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Global climate change; sea level rise; nodal tide
ID RECORDS
AB The 18.6-year nodal tide is a component of all tide gauge records. It can affect estimates of sea level acceleration, in particular for tide gauge records with lengths of less than 60 years. We provide an analytic solution that shows the effect of the nodal tide on estimates of sea level trend and acceleration. By adding a term to the least squares formulation used to estimate sea level trend and acceleration, we can account for the nodal tide and eliminate its effect on the estimate. Using representative world-wide tide gauge records, we demonstrate that accounting for the nodal tide can improve estimates, particularly of acceleration.
C1 [Houston, J. R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
RP Houston, JR (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM james.r.houston@usace.army.mil; dean@coastal.ufl.edu
NR 24
TC 8
Z9 8
U1 0
U2 4
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SEP
PY 2011
VL 27
IS 5
BP 801
EP 807
DI 10.2112/JCOASTRES-D-11-00045.1
PG 7
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 815KF
UT WOS:000294523800001
ER
PT J
AU Houston, JR
Dean, RG
AF Houston, J. R.
Dean, R. G.
TI Reply to: Donoghue, JF and Parkinson, RW, 2011. Discussion of: Houston,
JR and Dean, RG, 2011. Sea-Level Acceleration Based on US Tide Gauges
and Extensions of Previous Global-Gauge Analyses. Journal of Coastal
Research, 27(3), 409-417
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Editorial Material
C1 [Houston, J. R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Dean, R. G.] Univ Florida, Dept Civil & Coastal Civil Engn, Gainesville, FL 32611 USA.
RP Houston, JR (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM james.r.houston@usace.army.mil; dean@coastal.ufl.edu
NR 4
TC 1
Z9 1
U1 0
U2 0
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SEP
PY 2011
VL 27
IS 5
BP 997
EP 998
DI 10.2112/11A-00010.1
PG 2
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 815KF
UT WOS:000294523800019
ER
PT J
AU Propper, RE
Januszewski, A
Christman, SD
Brunye, TT
AF Propper, Ruth E.
Januszewski, Ashley
Christman, Stephen D.
Brunye, Tad T.
TI Increased Anger is Associated With Increased Hemispheric Asymmetry
Support for Anger-Tympanic Membrane Relationships
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Hemispheric asymmetry; affect; anger; hostility; lateralization
ID VISUAL-FIELD STIMULATION; ACTIVATION; MOOD
AB We recently reported that increased anger/hostility is associated with an increased imbalance of hemispheric activity, regardless of which particular hemisphere is more active (as indicated by increased absolute difference in temperature between the right and left tympanic membrane (ar-lTMT; Propper et al., J Nerv Ment Dis 198:691-694, 2010). In that study, we examined baseline levels of emotion and ar-lTMT; in this study, we used sustained unilateral gaze to manipulate hemispheric activity to further investigate the nature of the relationship between anger, ar-lTMT, and hemispheric imbalance. Both rightward (significantly) and leftward (modestly) sustained unilateral gaze increased anger, providing further evidence that anger is associated with the asymmetry of hemispheric activation. We also support our previous work demonstrating a relationship between increased anger and increased ar-lTMT. This is the second study supporting the use of ar-lTMT as a simple and convenient measure of hemispheric activation and as an objective correlate of anger.
C1 [Propper, Ruth E.; Januszewski, Ashley] Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA.
[Christman, Stephen D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
[Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Brunye, Tad T.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, 1 Normal Ave, Montclair, NJ 07043 USA.
EM propperr@mail.montclair.edu
FU US Army [W911QY-09-P-0567, W911QY-10-P-0420]
FX This work was supported by US Army Contracts W911QY-09-P-0567 and
W911QY-10-P-0420. The opinions expressed herein are those of the authors
and not necessarily of the US Army. Data collection was performed at
Merrimack College, North Andover, MA.
NR 16
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD SEP
PY 2011
VL 199
IS 9
BP 716
EP 720
DI 10.1097/NMD.0b013e318229d95a
PG 5
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 814JT
UT WOS:000294447300018
PM 21878789
ER
PT J
AU Van Orden, J
van der Rhee, B
Schmidt, GM
AF Van Orden, Joseph
van der Rhee, Bo
Schmidt, Glen M.
TI Encroachment Patterns of the "Best Products" from the Last Decade
SO JOURNAL OF PRODUCT INNOVATION MANAGEMENT
LA English
DT Article
ID INNOVATION; RELIABILITY; MARKET; TECHNOLOGIES; CONSEQUENCES; MODEL
AB Based on the examination of 239 "best products" (all those on Business Week's annual lists from the past decade), this article tests and validates a conceptual framework identifying six ways in which new products open new markets and/or encroach on original products. Three of these six scenarios involve high-end encroachment (the new product first opens a new high-end market, or enters at the high end of an existing market, and then diffuses down-market), and three scenarios involve low-end encroachment (encroachment starts at the low end, followed by diffusion up-market). As illustrated in a 2 x 3 matrix, high-end encroachment ensues when the new product enhances performance with regard to the market's core attribute (low-end encroachment ensues when this performance is diminished). The three high-end sub-types and three low-end sub-types are determined by the strength of performance along an ancillary attribute dimension. If the ancillary attribute performance is week, then the encroachment of the new product on the old market is immediate (corresponding to immediate high-end encroachment and immediate low-end encroachment, respectively). If the ancillary performance is moderate, then the new product expands the market at the high or low end (corresponding to new-attribute high-end encroachment and fringe-market low-end encroachment, respectively). If the ancillary performance is strong, then the new product first opens an entirely new market at the high or low end (corresponding to new-market high-end encroachment and detached-market low-end encroachment, respectively). The reliability and comprehensiveness of the encroachment framework is tested by asking a panel of eight judges to categorize each of the 239 products. Results show inter-judge reliability of 98%, with all products falling within one of the six encroachment categories. Each of the encroachment types has unique implications on product positioning and pricing, as further discussed in the paper. Thus the model helps firms identify and analyze the various possible strategies that they might choose from when introducing new products.
C1 [Van Orden, Joseph] W Point Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
[Schmidt, Glen M.] Univ Utah, David Eccles Sch Business, Salt Lake City, UT 84112 USA.
RP Van Orden, J (reprint author), W Point Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
EM jvanorden@rinchem.com
NR 46
TC 4
Z9 4
U1 3
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0737-6782
EI 1540-5885
J9 J PROD INNOVAT MANAG
JI J. Prod. Innov. Manage.
PD SEP
PY 2011
VL 28
IS 5
BP 726
EP 743
DI 10.1111/j.1540-5885.2011.00834.x
PG 18
WC Business; Engineering, Industrial; Management
SC Business & Economics; Engineering
GA 812BO
UT WOS:000294262900008
ER
PT J
AU Mishchenko, MI
Videen, G
Rosenbush, VK
Yatskiv, YS
AF Mishchenko, Michael I.
Videen, Gorden
Rosenbush, Vera K.
Yatskiv, Yaroslav S.
TI Polarimetric detection, characterization, and remote sensing Preface
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Editorial Material
C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
[Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA.
[Rosenbush, Vera K.; Yatskiv, Yaroslav S.] Natl Acad Sci Ukraine, Main Astron Observ, UA-03680 Kiev, Ukraine.
RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA.
EM mmishchenko@giss.nasa.gov
RI Mishchenko, Michael/D-4426-2012
NR 4
TC 1
Z9 1
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD SEP
PY 2011
VL 112
IS 13
SI SI
BP 2042
EP 2045
DI 10.1016/j.jqsrt.2011.04.004
PG 4
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 815IC
UT WOS:000294518300002
ER
PT J
AU Muinonen, K
Tyynela, J
Zubko, E
Lindqvist, H
Penttila, A
Videen, G
AF Muinonen, Karri
Tyynela, Jani
Zubko, Evgenij
Lindqvist, Hannakaisa
Penttila, Antti
Videen, Gorden
TI Polarization of light backscattered by small particles
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Light scattering; Polarization; Depolarization; Small particle;
Interference; Backscattering
ID DISCRETE-DIPOLE APPROXIMATION; GAUSSIAN RANDOM PARTICLES; INTERNAL
ELECTRIC-FIELDS; NEGATIVE POLARIZATION; OPTICAL-PROPERTIES; SCATTERING
CHARACTERISTICS; NONSPHERICAL PARTICLES; AEROSOL-PARTICLES; DUST
PARTICLES; T-MATRIX
AB We study scattering of light by wavelength-scale spherical, cubic, and spheroidal particles as well as clusters of spherical particles for equal-volume-sphere size parameters 4 <= x <= 10 and refractive indices 1.1 <= m <= 2.0. Such particles exhibit three specific features in the regime of backscattering: first, the intensity shows a backscattering peak; second, the degree of linear polarization for unpolarized incident light is negative; and, third, the depolarization ratio is double-lobed. We find that the overall characteristics of the scattering-matrix elements can be explained by an internal field composed of waves propagating in opposite directions near the particle perimeter and forming standing waves, as well as a wave propagating forward with the wavelength of the internal medium. When moving from the central axis of the particle toward its perimeter, the internal field changes from a forward-propagating wave with a wavelength dictated by the particle refractive index toward a standing wave with an apparent wavelength of the surrounding medium. The mapping of the internal field to the scattered far field is like an interference dial where rotation of the dial by a quarter of a wavelength on the particle perimeter results in a change from a destructive to constructive interference feature in the angular patterns (or vice versa). The dial is a manifestation of a well-known rule of thumb: the number of maxima or minima in the scattering-matrix elements is given by the size parameter. We explain the backscattering peak as deriving from the backward-propagating internal wave near the particle perimeter. Negative polarization follows from the spatial asymmetry of the internal fields: inside the particle, the fields are amplified near the central plane perpendicular to the polarization state of incident light, resulting in more pronounced interference effects for the perpendicular polarization than for the parallel polarization. The double-lobe feature in the depolarization results from the same internal-field structure with leading cross-polarized fields located slightly different from the copolarized fields. We discuss practical implications of these findings for the retrieval of particle sizes, shapes, and refractive indices from observations and laboratory experiments. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Muinonen, Karri; Tyynela, Jani; Zubko, Evgenij; Lindqvist, Hannakaisa; Penttila, Antti] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland.
[Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland.
[Zubko, Evgenij] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA.
RP Muinonen, K (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland.
EM Karri.Muinonen@helsinki.fi
RI Tyynela, Jani/H-4761-2011; Penttila, Antti/C-4886-2012
OI Penttila, Antti/0000-0001-7403-1721
FU Academy of Finland [127461, 125180]; NASA [NNX10AP93G, NNX11AB25G]
FX The research has been partially funded by the Academy of Finland
(contracts 127461 and 125180), NASA Outer Planets Research Program
(contract NNX10AP93G), and NASA Lunar Advanced Science and Exploration
Research Program (contract NNX11AB25G). CSC, the IT Center for Science
Ltd., Finland, is acknowledged for providing the computing resources. We
appreciate the constructive remarks by the anonymous reviewers, and
would like to thank K. Lumme for the suggestion to include cubic
particles in our study.
NR 37
TC 13
Z9 13
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD SEP
PY 2011
VL 112
IS 13
SI SI
BP 2193
EP 2212
DI 10.1016/j.jqsrt.2011.06.009
PG 20
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 815IC
UT WOS:000294518300014
ER
PT J
AU Katte, N
Haus, JW
Powers, P
Sarangan, A
Gao, J
Scalora, M
AF Katte, Nkorni
Haus, Joseph W.
Powers, Peter
Sarangan, Andrew
Gao, Jian
Scalora, Michael
TI Third-order nonlinear optical properties of metallodielectric stacks
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Article
ID PHOTONIC BANDGAP STRUCTURES; ENHANCEMENT; COMPOSITES; DEPENDENCE;
METALS; SIZE
AB We report simulations of nonlinear optical transmission of an optical beam through heterogeneous metallodielectric stacks under the action of nonlinear absorption. We use the finite element method (FEM) with two-dimensional transverse effects and transfer matrix method simulation techniques as complementary methods to validate the FEM approach. We find a significant nonlinear absorption effect across spectral regimes where transmission is high. We compare the results with energy and group velocity results, but the enhancement of the nonlinear response is attributed to field confinement in the metal layers. (C) 2011 Optical Society of America
C1 [Katte, Nkorni; Haus, Joseph W.; Powers, Peter; Sarangan, Andrew; Gao, Jian] Univ Dayton, Electroopt Program, Dayton, OH 45469 USA.
[Haus, Joseph W.; Powers, Peter] Univ Dayton, Dept Phys, Dayton, OH 45469 USA.
[Scalora, Michael] USA, Aviat & Missile Command, Charles M Bowden Res Facil, Redstone Arsenal, AL 35898 USA.
RP Haus, JW (reprint author), Univ Dayton, Electroopt Program, 300 Coll Pk, Dayton, OH 45469 USA.
EM jwhaus@udayton.edu
NR 30
TC 2
Z9 2
U1 1
U2 6
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD SEP
PY 2011
VL 28
IS 9
BP 2277
EP 2283
PG 7
WC Optics
SC Optics
GA 814WY
UT WOS:000294489100033
ER
PT J
AU Sullivan, NJ
Hensley, L
Asiedu, C
Geisbert, TW
Stanley, D
Johnson, J
Honko, A
Olinger, G
Bailey, M
Geisbert, JB
Reimann, KA
Bao, S
Rao, S
Roederer, M
Jahrling, PB
Koup, RA
Nabel, GJ
AF Sullivan, Nancy J.
Hensley, Lisa
Asiedu, Clement
Geisbert, Thomas W.
Stanley, Daphne
Johnson, Joshua
Honko, Anna
Olinger, Gene
Bailey, Michael
Geisbert, Joan B.
Reimann, Keith A.
Bao, Saran
Rao, Srinivas
Roederer, Mario
Jahrling, Peter B.
Koup, Richard A.
Nabel, Gary J.
TI CD8(+) cellular immunity mediates rAd5 vaccine protection against Ebola
virus infection of nonhuman primates
SO NATURE MEDICINE
LA English
DT Article
ID HEMORRHAGIC-FEVER; MARBURG VIRUS; INDUCTION; ANTIBODY
AB Vaccine-induced immunity to Ebola virus infection in nonhuman primates (NHPs) is marked by potent antigen-specific cellular and humoral immune responses(1,2); however, the immune mechanism of protection remains unknown. Here we define the immune basis of protection conferred by a highly protective recombinant adenovirus virus serotype 5 (rAd5) encoding Ebola virus glycoprotein (GP)(1,3) in NHPs. Passive transfer of high-titer polyclonal antibodies from vaccinated Ebola virus-immune cynomolgus macaques to naive macaques failed to confer protection against disease, suggesting a limited role of humoral immunity. In contrast, depletion of CD3(+) T cells in vivo after vaccination and immediately before challenge eliminated immunity in two vaccinated macaques, indicating a crucial requirement for T cells in this setting. The protective effect was mediated largely by CD8(+) cells, as depletion of CD8(+) cells in vivo using the cM-T807 monoclonal antibody (mAb), which does not affect CD4(+) T cell or humoral immune responses, abrogated protection in four out of five subjects. These findings indicate that CD8(+) cells have a major role in rAd5-GP-induced immune protection against Ebola virus infection in NHPs. Understanding the immunologic mechanism of Ebola virus protection will facilitate the development of vaccines for Ebola and related hemorrhagic fever viruses in humans.
C1 [Sullivan, Nancy J.; Asiedu, Clement; Stanley, Daphne; Bailey, Michael; Bao, Saran; Rao, Srinivas; Roederer, Mario; Koup, Richard A.; Nabel, Gary J.] US Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, US Natl Inst Hlth, Bethesda, MD USA.
[Hensley, Lisa; Geisbert, Thomas W.; Johnson, Joshua; Honko, Anna; Olinger, Gene; Geisbert, Joan B.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Reimann, Keith A.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Jahrling, Peter B.] US Natl Inst Allergy & Infect Dis, Integrated Res Facil, US Natl Inst Hlth, Bethesda, MD USA.
RP Sullivan, NJ (reprint author), US Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, US Natl Inst Hlth, Bethesda, MD USA.
EM nsullivan@nih.gov
OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841;
Honko, Anna/0000-0001-9165-148X
FU National Center for Research Resource, US National Institutes of Health
[R24RR016001]; US National Institutes of Health
FX We thank D. Jeffers, T. Suhana, A. Tislerics and B. Hartman for help
with manuscript preparation; M. Cichanowski for graphics; D. Braun, K.
Daddario and C. Rice for technical and animal care assistance; S. Norris
and M. Nason for assistance with statistical considerations; and K.
Kenyon for editorial support. We thank D. Neville (US National Institute
of Mental Health) for the generous gift of FN18-CRM9 immunotoxin.
Reagent support was provided by the Nonhuman Primate Reagent Resource
(grant number R24RR016001 from the National Center for Research
Resource, US National Institutes of Health). Support for this work was
provided by the Intramural Research Program of the US National
Institutes of Health. Opinions, interpretations, conclusions and
recommendations are those of the author and are not necessarily endorsed
by the US Army or the Department of Defense.
NR 20
TC 86
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U1 1
U2 20
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
J9 NAT MED
JI Nat. Med.
PD SEP
PY 2011
VL 17
IS 9
BP 1128
EP U135
DI 10.1038/nm.2447
PG 5
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 816MM
UT WOS:000294605100034
PM 21857654
ER
PT J
AU Hoge, CW
Castro, CA
AF Hoge, Charles W.
Castro, Carl A.
TI Blast-Related Traumatic Brain Injury in U.S. Military Personnel
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Castro, Carl A.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
NR 4
TC 10
Z9 11
U1 1
U2 1
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD SEP 1
PY 2011
VL 365
IS 9
BP 860
EP 860
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 813YC
UT WOS:000294405200019
PM 21879907
ER
PT J
AU Wirtz, ED
Fredericks, G
Robitschek, J
Cable, BB
AF Wirtz, Eric D.
Fredericks, Gregory
Robitschek, Jon
Cable, Benjamin B.
TI RNA Interference of Transforming Growth Factor-beta 2 in Human
Respiratory Fibroblasts
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation-and-
OTO-EXPO
CY SEP 25-29, 2010
CL Boston, MA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn, UMDNJ-New Jersey Med Sch
DE interfering RNA; wound healing; TGF-beta 2
ID GROWTH-FACTOR-BETA; TGF-BETA; IN-VIVO; MITOMYCIN-C; FIBROSIS; ANTIBODY;
WOUNDS
AB Objective. Transforming growth factor-beta 2 (TGF-beta 2) is a principal cytokine of interest in the pathogenesis of scar formation and is a potential target for future molecular-based adjunctive therapies. The authors hypothesize that interfering RNA (RNAi) can be used to modulate TGF-beta 2 production in cultured human respiratory fibroblasts.
Study Design. Basic science.
Setting. Laboratory.
Subjects and Methods. RNAi constructs targeted to the TGF-beta 2 transcript were complexed with microsomal lipids and applied to human fibroblasts in cell culture. Transfection efficiency and cell viability were measured by fluorescence microscopy. Messenger RNA (mRNA) for TGF-beta 2 was measured 48 hours posttransfection using real-time quantitative PCR. The quantity of TGF-beta 2 protein produced with increasing concentrations of RNAi was measured using enzymelinked immunosorbent assay. The function of RNAi-treated fibroblasts was tested using a wound-healing assay.
Results. Transfection efficiency of more than 80% was achieved with minimal induced cell death. Treated cells showed selective knockdown of 80% of TGF-beta 2 mRNA, which was confirmed with negative controls. As the concentration of RNAi was increased, an incremental decrease in TGF-beta 2 protein was measured.
Conclusion. RNAi technology is an effective means of localized and transient gene silencing in cultured human fibroblasts. Transfection can be achieved using microsome complexed RNAi with minimal induced cell death. This preliminary result shows promise for future in vitro studies.
C1 [Wirtz, Eric D.] Tripler Army Med Ctr, ENT Clin 3C, Honolulu, HI 96859 USA.
[Robitschek, Jon] Landstuhl Reg Med Ctr, Landstuhl, Germany.
RP Wirtz, ED (reprint author), Tripler Army Med Ctr, ENT Clin 3C, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM eric.d.wirtz@us.army.mil
NR 17
TC 0
Z9 0
U1 1
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD SEP
PY 2011
VL 145
IS 3
BP 476
EP 481
DI 10.1177/0194599811409534
PG 6
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 814OY
UT WOS:000294467700021
PM 21572080
ER
PT J
AU Darter, BJ
Wilken, JM
AF Darter, Benjamin J.
Wilken, Jason M.
TI Gait Training With Virtual Reality-Based Real-Time Feedback: Improving
Gait Performance Following Transfemoral Amputation
SO PHYSICAL THERAPY
LA English
DT Article
ID LOWER-LIMB AMPUTEES; ENERGY-COST; PROSTHETIC FEET; WALKING SPEED;
AMBULATION; REHABILITATION; DETERMINANTS; PELVIS; PAIN
AB Background and Purpose. Gait training is an important component of rehabilitation after lower-extremity amputation. Abnormal gait performance often persists even for individuals who reacquire a high level of function. This case report describes the use of a virtual reality (VR)-based gait training program that provides real-time feedback in order to improve biomechanical and physiological performance. The aim of this case report is to describe the effects of the training in a person with a transfemoral amputation.
Case Description. A 24-year-old man with a transfemoral amputation completed a 3-week gait training program. The intervention consisted of 12 sessions of treadmill walking with real-time visual feedback on full-body gait kinematics. A treating therapist directed the patient's attention to specific gait deviations as a means to normalize gait biomechanics.
Outcomes. The patient completed overground biomechanical gait analyses and multiple-speed treadmill tests 3 weeks apart prior to and following the training program. Biomechanical gait analyses indicated the training produced improved frontal-plane hip, pelvis, and trunk motion during overground walking. Improvement in trunk motion was observed at the posttraining test, and improvements in pelvis and hip motion were observed at the 3-week follow-up test. Decreases of up to 23% in oxygen consumption also were demonstrated.
Discussion. Although the exact contribution of the visual feedback could not be isolated, the training was effective in improving the patient's walking performance. Biomechanical data suggest correcting trunk motion and increasing hip abductor strength (force-generating capacity) may be important in facilitating improvements at the pelvis and hip. Observed improvements in oxygen consumption were significantly larger than achieved through previously reported interventions.
C1 [Darter, Benjamin J.; Wilken, Jason M.] Brooke Army Med Ctr, Mil Performance Lab, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Darter, BJ (reprint author), Brooke Army Med Ctr, Mil Performance Lab, Dept Orthopaed & Rehabil, Ctr Intrepid, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM benjamin.darter@us.army.mil
OI Wilken, Jason/0000-0002-5556-7667
FU Military Amputee Research Program
FX Support for this project was provided by the Military Amputee Research
Program through grant awards to the authors.
NR 30
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Z9 19
U1 1
U2 19
PU AMER PHYSICAL THERAPY ASSOC
PI ALEXANDRIA
PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA
SN 0031-9023
EI 1538-6724
J9 PHYS THER
JI Phys. Ther.
PD SEP
PY 2011
VL 91
IS 9
BP 1385
EP 1394
DI 10.2522/ptj.20100360
PG 10
WC Orthopedics; Rehabilitation
SC Orthopedics; Rehabilitation
GA 814NB
UT WOS:000294461600008
PM 21757579
ER
PT J
AU Garcia-Rodriguez, C
Geren, IN
Lou, J
Conrad, F
Forsyth, C
Wen, W
Chakraborti, S
Zao, H
Manzanarez, G
Smith, TJ
Brown, J
Tepp, WH
Liu, N
Wijesuriya, S
Tomic, MT
Johnson, EA
Smith, LA
Marks, JD
AF Garcia-Rodriguez, C.
Geren, I. N.
Lou, J.
Conrad, F.
Forsyth, C.
Wen, W.
Chakraborti, S.
Zao, H.
Manzanarez, G.
Smith, T. J.
Brown, J.
Tepp, W. H.
Liu, N.
Wijesuriya, S.
Tomic, M. T.
Johnson, E. A.
Smith, L. A.
Marks, J. D.
TI Re: oNeutralizing human monoclonal antibodies binding multiple serotypes
of botulinum neurotoxin by Garcia-Rodriguez et al., PEDS, 2011;24:321331
SO PROTEIN ENGINEERING DESIGN & SELECTION
LA English
DT Letter
ID ORGANISMS
C1 [Garcia-Rodriguez, C.; Geren, I. N.; Lou, J.; Conrad, F.; Forsyth, C.; Wen, W.; Chakraborti, S.; Zao, H.; Manzanarez, G.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia & Pharmaceut Chem, San Francisco Gen Hosp, San Francisco, CA 94110 USA.
[Smith, T. J.; Brown, J.; Smith, L. A.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Tepp, W. H.; Johnson, E. A.] Univ Wisconsin, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA.
[Liu, N.; Wijesuriya, S.; Tomic, M. T.] XOMA US LLC, Berkeley, CA 94710 USA.
RP Marks, JD (reprint author), Univ Calif San Francisco, Dept Anesthesia & Pharmaceut Chem, San Francisco Gen Hosp, Rm 3C-38,1001 Potrero Ave, San Francisco, CA 94110 USA.
EM marksj@anesthesia.ucsf.edu
NR 7
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1741-0126
J9 PROTEIN ENG DES SEL
JI Protein Eng. Des. Sel.
PD SEP
PY 2011
VL 24
IS 9
SI SI
BP 633
EP 634
DI 10.1093/protein/gzr011
PG 2
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 815UP
UT WOS:000294555600003
ER
PT J
AU Wiles, GC
Lawson, DE
Lyon, E
Wiesenberg, N
D'Arrigo, RD
AF Wiles, Gregory C.
Lawson, Daniel E.
Lyon, Eva
Wiesenberg, Nicholas
D'Arrigo, R. D.
TI Tree-ring dates on two pre-Little Ice Age advances in Glacier Bay
National Park and Preserve, Alaska, USA
SO QUATERNARY RESEARCH
LA English
DT Article
DE Glacier Bay; Alaska; Tree rings; Dendrochronology; Glacial history;
First millennium AD
ID 1ST MILLENNIUM AD; SOUTHEAST ALASKA; TIDEWATER GLACIERS; RADIOCARBON
AGE; SEA-LEVEL; HISTORY; FLUCTUATIONS; PACIFIC; PLEISTOCENE; RETREAT
AB Two interstadial tree ring-width chronologies from Geikie Inlet, Glacier Bay Southeast, Alaska were built from 40 logs. One of these chronologies has been calendar dated to AD 224-999 (775 yr) crossdating with a living ring-width chronology from Prince William Sound, Alaska. Trees in this chronology were likely killed through inundation by sediments and meltwater from the advancing Geikie Glacier and its tributaries ca. AD 850. The earlier tree-ring chronology spans 545 yr and is a floating ring-width series tied to radiocarbon ages of about 3000 cal yr BP. This tree-ring work indicates two intervals of glacial expansion by the Geikie Glacier system toward the main trunk glacier in Glacier Bay between 3400 and 3000 cal yr BP and again about AD 850. The timing of both expansions is consistent with patterns of ice advance at tidewater glaciers in other parts of Alaska and British Columbia about the same time, and with a relative sea-level history from just outside Glacier Bay in Icy Strait. This emerging tree-ring dated history builds on previous radiocarbon-based glacial histories and is the first study to use tree-ring dating to assign calendar dates to glacial activity for Glacier Bay. (C) 2011 University of Washington. Published by Elsevier Inc. All rights reserved.
C1 [Wiles, Gregory C.] Coll Wooster, Dept Geol, Wooster, OH 44691 USA.
[Lawson, Daniel E.] CRREL, Hanover, NH 03755 USA.
[Lyon, Eva] Utah State Univ, Dept Geol, Logan, UT 84322 USA.
[D'Arrigo, R. D.] Lamont Doherty Earth Observ, Tree Ring Lab, Palisades, NY 10964 USA.
RP Wiles, GC (reprint author), Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA.
EM gwiles@wooster.edu; Daniel.E.lawson@usace.army.mil;
e.lyon@aggiemail.usu.edu; nickthebomb@hotmail.com; rdd@ldeo.columbia.edu
FU National Science Foundation [ATM-0902799]; CRREL; COE; Dickey Foundation
at Dartmouth College; National Geographic Society; Keck Geology
Consortium; Lamont-Doherty [7473]
FX This work was supported by the National Science Foundation
(ATM-0902799). We gratefully acknowledge the logistical support and
expertise of the National Park Service. We thank CRREL, COE, the Arctic
Studies Program and Dickey Foundation at Dartmouth College, the National
Geographic Society and the Keck Geology Consortium for their funding
contributions to the study. Lamont-Doherty Contribution #7473.
NR 45
TC 6
Z9 7
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0033-5894
J9 QUATERNARY RES
JI Quat. Res.
PD SEP
PY 2011
VL 76
IS 2
BP 190
EP 195
DI 10.1016/j.yqres.2011.05.005
PG 6
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA 815NQ
UT WOS:000294532700002
ER
PT J
AU Duddu, R
Zhang, MX
Damavarapu, R
Gelber, N
AF Duddu, Raja
Zhang, Mao-Xi
Damavarapu, Reddy
Gelber, Nathaniel
TI Molten-State Nitration of Substituted Imidazoles: New Synthetic
Approaches to the Novel Melt-Cast Energetic Material,
1-Methyl-2,4,5-trinitroimidazole
SO SYNTHESIS-STUTTGART
LA English
DT Article
DE imidazoles; 1-methyl-2,4,5-trinitroimidazole; nitration; molten-state;
solvent-free
ID HETEROCYCLES; SALTS; MTNI
AB Novel, one-step synthetic routes for the preparation of 1-methyl-2,4,5-trinitroimidazole (MTNI) are described. In addition, a new, molten-state nitration method for the synthesis of 1-methyl-2,4,5-trinitroimidazole is developed.
C1 [Duddu, Raja; Zhang, Mao-Xi] USA, ARDEC, SAIC, Picatinny Arsenal, NJ 07806 USA.
RP Duddu, R (reprint author), USA, ARDEC, SAIC, Bldg 3028, Picatinny Arsenal, NJ 07806 USA.
EM raja.duddu@us.army.mil; reddy.damavarapu@us.army.mil
NR 37
TC 6
Z9 7
U1 4
U2 13
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0039-7881
EI 1437-210X
J9 SYNTHESIS-STUTTGART
JI Synthesis
PD SEP
PY 2011
IS 17
BP 2859
EP 2864
DI 10.1055/s-0030-1260148
PG 6
WC Chemistry, Organic
SC Chemistry
GA 810WJ
UT WOS:000294158700024
ER
PT J
AU Welkos, S
Cote, CK
Hahn, U
Shastak, O
Jedermann, J
Bozue, J
Jung, G
Ruchala, P
Pratikhya, P
Tang, T
Lehrer, RI
Beyer, W
AF Welkos, S.
Cote, C. K.
Hahn, U.
Shastak, O.
Jedermann, J.
Bozue, J.
Jung, G.
Ruchala, P.
Pratikhya, P.
Tang, T.
Lehrer, R. I.
Beyer, W.
TI Humanized theta-Defensins (Retrocyclins) Enhance Macrophage Performance
and Protect Mice from Experimental Anthrax Infections
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID HUMAN ALPHA-DEFENSINS; HERPES-SIMPLEX-VIRUS; BACILLUS-ANTHRACIS;
ANTIMICROBIAL PEPTIDES; SPORE GERMINATION; HOST RESPONSE; LETHAL TOXIN;
MOUSE MODEL; HIV-1; BINDING
AB Retrocyclins are humanized versions of the theta-defensin peptides expressed by the leukocytes of several nonhuman primates. Previous studies, performed in serum-free media, determined that retrocyclins 1 (RC1) and RC2 could prevent successful germination of Bacillus anthracis spores, kill vegetative B. anthracis cells, and inactivate anthrax lethal factor. We now report that retrocyclins are extensively bound by components of native mouse, human, and fetal calf sera, that heat-inactivated sera show greatly enhanced retrocyclin binding, and that native and (especially) heat-inactivated sera greatly reduce the direct activities of retrocyclins against spores and vegetative cells of B. anthracis. Nevertheless, we also found that retrocyclins protected mice challenged in vivo by subcutaneous, intraperitoneal, or intranasal instillation of B. anthracis spores. Retrocyclin 1 bound extensively to B. anthracis spores and enhanced their phagocytosis and killing by murine RAW264.7 cells. Based on the assumption that spore-bound RC1 enters phagosomes by "piggyback phagocytosis," model calculations showed that the intraphagosomal concentration of RC1 would greatly exceed its extracellular concentration. Murine alveolar macrophages took up fluorescently labeled retrocyclin, suggesting that macrophages may also acquire extracellular RC1 directly. Overall, these data demonstrate that retrocyclins are effective in vivo against experimental murine anthrax infections and suggest that enhanced macrophage function contributes to this property.
C1 [Hahn, U.; Shastak, O.; Jedermann, J.; Beyer, W.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Welkos, S.; Cote, C. K.; Bozue, J.] USA, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD USA.
[Jung, G.; Ruchala, P.; Pratikhya, P.; Tang, T.; Lehrer, R. I.] Univ Hohenheim, D-7000 Stuttgart, Germany.
RP Lehrer, RI (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
EM susan.welkos@amedd.army.mil; rlehrer@mednet.ucla.edu
FU JSTO-CBD/DTRA [1.1A0010-07-RDB]; German Ministry of Defense
[E/UR3G/5G002/5A800]; NIH [RO1-AI070726]
FX The USAMRIID research described in this paper was supported by
JSTO-CBD/DTRA project 1.1A0010-07-RDB. The Universitat Hohenheim
research was funded by the German Ministry of Defense (grant
E/UR3G/5G002/5A800). Research at UCLA was funded by a grant,
RO1-AI070726, from the NIH.
NR 59
TC 21
Z9 21
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD SEP
PY 2011
VL 55
IS 9
BP 4238
EP 4250
DI 10.1128/AAC.00267-11
PG 13
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 808CW
UT WOS:000293953900040
PM 21768520
ER
PT J
AU Orr, JM
Barnett, JC
Leath, CA
AF Orr, Jennifer M.
Barnett, Jason C.
Leath, Charles A., III
TI Incidence of subsequent abnormal cytology in cervical cancer patients
completing five-years of post treatment surveillance without evidence of
recurrence
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE Pap testing; Cervical cancer; Survivorship; Prolonged surveillance
ID FOLLOW-UP; RADICAL HYSTERECTOMY; WOMEN; CARCINOMA; DIAGNOSIS; PATTERNS;
RISK
AB Objective. To determine the incidence of subsequent abnormal cervical or vaginal cytology and confirmatory histology in women completing five-years of surveillance for cervical cancer without recurrence.
Methods. Following IRB approval, a tumor registry database identified women managed for all stages of cervical cancer from 1990 to 2003 who after completion of 60 months of active surveillance following primary therapy underWent continued vaginal or cervical cytologic surveillance. Retrospective review was performed to determine demographics. clinicopathologic variables, vaginal or cervical cytology and outcomes.
Results. Sixty-one women were identified with a median age at diagnosis of 41 (range 23-81). 72% of women were Caucasian, 16% were African-American with the remainder primarily Asian. Squamous cell carcinoma was the most common histology and present in 47 women (77%) with an equal proportion of women having G1 and G2 tumors. 80% of patients had early stage disease (Stages IA1-IIA). Median follow-up after completing five-years of active surveillance for all patients was 143 months and a total of 303 Pap tests were performed with the mean/median number of five cytologic evaluations per patient. A total of 17 (5.6%) [95% Cl, 3.5-8.8%] abnormal Pap tests were reported, which led to the performance of three diagnostic procedures. One case of moderate vaginal dysplasia was diagnosed and treated.
Conclusions. Continued annual cytologic screening is of low yield in women completing five-years of surveillance that have remained free of recurrence. The incorporation of newer testing modalities including HPV testing may allow increases in the screening interval in this group of patients at relatively low risk for recurrence. Published by Elsevier Inc.
C1 [Barnett, Jason C.; Leath, Charles A., III] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA.
[Orr, Jennifer M.] William Beaumont Army Med Ctr, Dept Obstet & Gynecol, Ft Bliss, TX USA.
RP Leath, CA (reprint author), Dept OB GYN, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Trey_Leath@yahoo.com
OI Leath III, Charles/0000-0002-4034-6845
NR 23
TC 7
Z9 7
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD SEP
PY 2011
VL 122
IS 3
BP 501
EP 504
DI 10.1016/j.ygyno.2011.06.003
PG 4
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 810TY
UT WOS:000294151200008
PM 21714992
ER
PT J
AU Hamilton, CA
Miller, A
Miller, C
Krivak, TC
Farley, JH
Chernofsky, MR
Stany, MP
Rose, GS
Markman, M
Ozols, RF
Armstrong, DK
Maxwell, GL
AF Hamilton, Chad A.
Miller, Austin
Miller, Caela
Krivak, Thomas C.
Farley, John H.
Chernofsky, Mildred R.
Stany, Michael P.
Rose, G. Scott
Markman, Maurie
Ozols, Robert F.
Armstrong, Deborah K.
Maxwell, G. Larry
TI The impact of disease distribution on survival in patients with stage
III epithelial ovarian cancer cytoreduced to microscopic residual: A
gynecologic oncology group study
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE Epithelial ovarian cancer; Microscopic residual; Cytoreduction
ID SURGICAL CYTOREDUCTION; INTRAPERITONEAL CISPLATIN; NEOADJUVANT
CHEMOTHERAPY; AGGRESSIVE SURGERY; PROGNOSTIC-FACTORS; CARCINOMA;
PACLITAXEL; CARBOPLATIN; PREDICTION; CRITIQUE
AB Objective. To assess the survival impact of initial disease distribution on patients with stage III epithelial ovarian cancer (EOC) cytoreduced to microscopic residual.
Methods. We reviewed data from 417 stage III EOC patients cytoreduced to microscopic disease and given adjuvant intravenous platinum/paclitaxel on one of three randomized Gynecologic Oncology Group (COG) trials. We subdivided patients into three groups based on preoperative disease burden: (1) minimal disease (MD) defined by pelvic tumor and retroperitoneal metastasis (2) abdominal peritoneal disease (APD) with disease limited to the pelvis, retroperitoneum, lower abdomen and omentum; and (3) upper abdominal disease (DAD) with disease affecting the diaphragm, spleen, liver or pancreas. We assessed the survival impact of potential prognostic factors, focusing on initial disease distribution using a proportional hazards model and estimated Kaplan-Meier survival curves.
Results. The study groups had similar clinicopathologic characteristics. Median overall survival (OS) was not reached in MD patients compared to 80 and 56 months in the APD and UAD groups (P < 0.05). The five-year survival percentages for MD. APD. and UAD were 67%, 63%. and 45%. In multivariate analysis, the UAD group had a significantly worse prognosis than MD and APD both individually and combined (Progression Free Survival (PFS) Hazards Ratio (HR) 1.44; P=0.008 and OS HR 1.77; P=0.0004 compared to MD +APD).
Conclusion. Stage Ill WC patients with initial disease in the upper abdomen have a worse prognosis despite cytoreductive surgery to microscopic residual implying that factors beyond cytoreductive effort are important in predicting survival. Published by Elsevier Inc.
C1 [Hamilton, Chad A.; Miller, Caela; Farley, John H.; Stany, Michael P.; Rose, G. Scott; Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA.
[Miller, Austin] Roswell Pk Canc Inst, Gynecol Oncol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA.
[Krivak, Thomas C.] Univ Pittsburgh, Magee Womens Hosp, Div Gynecol Oncol, Pittsburgh, PA 15213 USA.
[Chernofsky, Mildred R.] Sibley Mem Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC USA.
[Markman, Maurie] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Med Oncol, Houston, TX 77030 USA.
[Ozols, Robert F.] Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA.
[Armstrong, Deborah K.] Johns Hopkins Kimmel Canc Ctr, Baltimore, MD USA.
[Maxwell, G. Larry] Womens Hlth Integrated Res Ctr Inova Hlth Syst, Annandale, VA USA.
RP Hamilton, CA (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM chad.a.hamilton@gmail.com
FU National Cancer Institute [CA 27469]; Gynecologic Oncology Group
Statistical Office [CA 37517]
FX This study was supported by the National Cancer Institute grants to the
Gynecologic Oncology Group Administrative Office (CA 27469) and the
Gynecologic Oncology Group Statistical Office (CA 37517). The following
Gynecologic Oncology Group member institutions participated in the
primary treatment studies: University of Alabama at Birmingham, Oregon
Health Sciences University, Duke University Medical Center. Abington
Memorial Hospital, University of Rochester Medical Center. Walter Reed
Army Medical Center. Wayne State University, University of Minnesota
Medical School. University of Southern California at Los Angeles.
University of Mississippi Medical Center. Colorado Gynecologic Oncology
Group P.C., University of California at Los Angeles, University of
Washington. University of Pennsylvania Cancer Center. University of
Miami School of Medicine. Milton S. Hershey Medical Center. Georgetown
University Hospital, University of Cincinnati. University of North
Carolina School of Medicine. University of Iowa Hospitals and Clinics.
University of Texas Southwestern Medical Center at Dallas. Indiana
University School of Medicine. Wake Forest University School of
Medicine, Albany Medical College, University of California Medical
Center at Irvine. Tufts-New England Medical Center,
Rush-Presbyterian-St. Luke's Medical Center, University of Kentucky.
Eastern Virginia Medical School, The Cleveland Clinic Foundation, Johns
Hopkins Oncology Center, State University of New York at Stony Brook,
Eastern Pennsylvania GYN/ONC Center, P.C.. Southwestern Oncology Group,
Washington University School of Medicine. Memorial Sloan-Kettering
Cancer Center, Columbus Cancer Council. University of Massachusetts
Medical School, Fox Chase Cancer Center. Medical University of South
Carolina. Women's Cancer Center. University of Oklahoma. University of
Virginia Health Sciences Center. University of Chicago, University of
Arizona Health Science Center, Tacoma General Hospital, Eastern
Collaborative Oncology Group. Thomas Jefferson University Hospital, Case
Western Reserve University. and Tampa Bay Cancer Consortium.
NR 37
TC 25
Z9 25
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD SEP
PY 2011
VL 122
IS 3
BP 521
EP 526
DI 10.1016/j.ygyno.2011.04.041
PG 6
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 810TY
UT WOS:000294151200012
PM 21683993
ER
PT J
AU Nayfeh, OM
AF Nayfeh, Osama M.
TI Radio-Frequency Transistors Using Chemical-Vapor-Deposited Monolayer
Graphene: Performance, Doping, and Transport Effects
SO IEEE TRANSACTIONS ON ELECTRON DEVICES
LA English
DT Article
DE Ambipolar; chemical vapor deposition (CVD); doping; graphene; mobility;
radio frequency (RF); transistor
ID EPITAXIAL-GRAPHENE; RESISTANCE; FILMS; DEVICES; LIMITS
AB Large-area graphene is synthesized by Cu-catalyzed chemical vapor deposition (CVD), transistors are constructed, and the dc/RF performance is examined. Top-gate transistors, i.e., with a gate length of 3 mu m and V-ds = 5 V, have a peak dc transconductance in excess of 20 mS/mm and a drive current of 0.5 A/mm. RF measurements achieve gigahertz extrinsic current-gain cutoff frequency with low back biasing. Back-gated devices are used to examine doping and transport effects that impact the performance. Good agreement between measurements and a drift-diffusion model is obtained for gapless graphene with a net p-type doping and asymmetric electron/hole mobility. The mean free path for scattering is extracted and reveals that the transport suffers from large levels of Coulomb scattering and short-range scattering. The results are of importance for understanding the performance potential of large-area CVD graphene in future RF devices.
C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Nayfeh, OM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM osama.nayfeh@us.army.mil
FU Army Research Laboratory
FX This work was supported through the Army Research Laboratory Director's
Strategic Initiative Program. The review of this paper was arranged by
Editor V. R. Rao.
NR 37
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U1 1
U2 23
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9383
J9 IEEE T ELECTRON DEV
JI IEEE Trans. Electron Devices
PD SEP
PY 2011
VL 58
IS 9
BP 2847
EP 2853
DI 10.1109/TED.2011.2159721
PG 7
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA 811BC
UT WOS:000294175900005
ER
PT J
AU Thomas, JL
Britt, TW
Odle-Dusseau, H
Bliese, PD
AF Thomas, Jeffrey L.
Britt, Thomas W.
Odle-Dusseau, Heather
Bliese, Paul D.
TI Dispositional Optimism Buffers Combat Veterans from the Negative Effects
of Warzone Stress on Mental Health Symptoms and Work Impairment
SO JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE dispositional optimism; PTSD; depression; combat exposure; deployment
demands; work impairment; warzone stress
ID FUNCTIONAL IMPAIRMENT; PSYCHOLOGICAL ADJUSTMENT; PSYCHIATRIC-DISORDERS;
EXPLANATORY STYLE; SELF-MASTERY; PRIMARY-CARE; RISK-FACTORS; IMPACT;
IRAQ; POPULATION
AB The study examined dispositional optimism s role in buffering the effect of warzone stress on mental health symptoms and mental health symptoms on work impairment. A total of 2,439 soldiers from an active-duty brigade combat team were surveyed following a 12-month deployment to Iraq. Posttraumatic stress disorder (PTSD) symptoms, depression symptoms, combat exposure, deployment demands, and work impairment were measured. Soldiers higher in dispositional optimism showed weaker relationships between combat exposure and PTSD symptoms, and between deployment demands and PTSD and depression symptoms. Dispositional optimism also buffered mental health symptom effects on work impairment. Dispositional optimism may protect soldiers from warzone stress and mental health symptoms. Potential mechanisms explaining how dispositional optimism may serve as a protective factor are discussed. (C) 2011 Wiley Periodicals, Inc. J Clin Psychol 67: 866-880, 2011.
C1 [Thomas, Jeffrey L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Britt, Thomas W.] Clemson Univ, Clemson, SC 29631 USA.
[Odle-Dusseau, Heather] Gettysburg Coll, Gettysburg, PA USA.
RP Thomas, JL (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM jeffrey.l.thomas@us.army.mil
RI Schueter, nicos/A-3625-2014
NR 51
TC 17
Z9 17
U1 4
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9762
J9 J CLIN PSYCHOL
JI J. Clin. Psychol.
PD SEP
PY 2011
VL 67
IS 9
BP 866
EP 880
DI 10.1002/jclp.20809
PG 15
WC Psychology, Clinical
SC Psychology
GA 811WN
UT WOS:000294248200004
PM 21590690
ER
PT J
AU Chen, XYK
Rathbone, CR
Walters, TJ
AF Chen, Xiaoyu K.
Rathbone, Christopher R.
Walters, Thomas J.
TI Treatment of Tourniquet-Induced Ischemia Reperfusion Injury with Muscle
Progenitor Cells
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE muscle function; satellite cells; cell tracking; stem cells; skeletal
muscle
ID MESENCHYMAL STEM-CELLS; RAT SKELETAL-MUSCLE; SATELLITE CELLS; FUNCTIONAL
IMPROVEMENT; CONTRACTILE FUNCTION; HYPERBARIC-OXYGEN; HINDLIMB ISCHEMIA;
IN-VITRO; RECOVERY; MECHANISMS
AB Background. Acute ischemia reperfusion injury (IRI) results in muscle atrophy and functional loss. Although studies have shown that stem cells can improve muscle function in chronic ischemia caused by vascular diseases, none investigated whether stem cells can improve muscle function following acute IRI. The primary purpose of this study was to determine whether transplantation of muscle progenitor cells (MPCs) improves recovery of muscle function after tourniquet (TK) induced IRI.
Methods. IRI was induced in rat hind limb muscles with a pneumatic TK (250 mmHg) for 3 h. Rats were then divided into two groups; receiving either intramuscular injection of MPCs or vehicle control into the injured tibialis anterior muscle 48 h after tourniquet application. Muscle mass, isometric contractile properties, and selected histologic properties were evaluated at 2 wk after ischemia.
Results. IRI resulted in significant reductions in absolute muscle force (N) and specific muscle force (N/cm(2)). MPC treatment significantly prevented the loss in muscle specific force compared with vehicle controls. The mass and cross sectional areas of the muscles were similar between treatment groups. Histologic results showed that a small number of transplanted cells differentiated and formed muscle fibers, which could potentially contribute to force generation. IRI caused significant fibrosis and inflammation, both of which could affect muscle-specific force, of which inflammation was reduced by MPCs treatment.
Conclusions. Intramuscular injection of MPCs may provide a beneficial treatment for improving functional recovery following IRI, and the beneficial effects are mainly through improving muscle quality (specific force) but not quantity (mass). Published by Elsevier Inc.
C1 [Rathbone, Christopher R.; Walters, Thomas J.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX 78676 USA.
[Chen, Xiaoyu K.] Wake Forest Inst Regenerat Med, Winston Salem, NC USA.
RP Walters, TJ (reprint author), USA, Inst Surg Res Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78676 USA.
EM thomas.walters@us.army.mil
FU Armed Forces Institute of Regenerative Medicine; U.S. Army Medical
Research and Medical Command; Department of Defense [USAMRAA
ORTP07-07128091]
FX X.C. is supported through a post-doctoral fellowship from the Armed
Forces Institute of Regenerative Medicine, administered through Wake
Forest Institute of Regenerative Medicine, Winston-Salem, NC. This study
was supported by the U.S. Army Medical Research and Medical Command and
the Orthopedic Trauma Research Program (USAMRAA ORTP07-07128091) of the
Department of Defense. The opinions or assertions contained herein are
the private views of the authors and are not to be construed as official
or as reflecting the views of the Department of the Army or the
Department of Defense (AR 360-5) or the Unites States government. The
authors are employees of the U.S. government, and this work was prepared
as part of their official duties. All work is supported by U.S. Army
Medical Research and Material Command.
NR 59
TC 10
Z9 10
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD SEP
PY 2011
VL 170
IS 1
BP E65
EP E73
DI 10.1016/j.jss.2011.05.061
PG 9
WC Surgery
SC Surgery
GA 804BD
UT WOS:000293627800009
PM 21777925
ER
PT J
AU Tan, E
Weiss, BM
Mena, E
Korde, N
Choyke, PL
Landgren, O
AF Tan, Esther
Weiss, Brendan M.
Mena, Esther
Korde, Neha
Choyke, Peter L.
Landgren, Ola
TI Current and future imaging modalities for multiple myeloma and its
precursor states
SO LEUKEMIA & LYMPHOMA
LA English
DT Review
DE Multiple myeloma; monoclonal gammopathy of undetermined significance;
smoldering multiple myeloma; skeletal survey; PET/CT; DCE MRI
ID POSITRON-EMISSION-TOMOGRAPHY; BONE-MARROW ANGIOGENESIS; UNDETERMINED
SIGNIFICANCE MGUS; HIGH-RISK MYELOMA; MONOCLONAL GAMMOPATHY; STAGING
SYSTEM; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; MULTIDETECTOR CT;
WORKING GROUP
AB Traditionally, the skeletal survey has been the standard modality for the detection of osteolytic bone disease in multiple myeloma. In addition to its poor sensitivity for the detection of osteolytic lesions, this modality is not able to identify extramedullary lesions and focal bone marrow involvement, nor measure response to therapy. The application of novel imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging such as fluorine-18 fluorodeoxyglucose positron emission tomography CT (F-18-FDG PET/CT) and fluorine-18 sodium fluoride positron emission tomography CT (F-18-NaF PET/CT) has the potential to overcome these limitations as well as provide prognostic information in precursor states and multiple myeloma. Also promising is the use of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) to measure vascular permeability, an important feature of myelomagenesis. This review summarizes the current status and possible future role of novel imaging modalities in multiple myeloma and its precursor states.
C1 [Tan, Esther; Weiss, Brendan M.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Dept Med, Washington, DC 20307 USA.
[Tan, Esther; Weiss, Brendan M.; Korde, Neha; Landgren, Ola] NCI, Multiple Myeloma Sect, Med Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
[Mena, Esther; Choyke, Peter L.] NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
RP Tan, E (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA.
EM esther.tan@us.army.mil; landgreo@mail.nih.gov
FU Intramural NIH HHS [Z01 BC010654-04]
NR 58
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Z9 20
U1 1
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1042-8194
J9 LEUKEMIA LYMPHOMA
JI Leuk. Lymphoma
PD SEP
PY 2011
VL 52
IS 9
BP 1630
EP 1640
DI 10.3109/10428194.2011.573036
PG 11
WC Oncology; Hematology
SC Oncology; Hematology
GA 811QM
UT WOS:000294228100007
PM 21649546
ER
PT J
AU Zachery, RA
Sastry, SS
Kumar, V
AF Zachery, Randy A.
Sastry, Shankar S.
Kumar, Vijay
TI Special Issue on Swarming in Natural and Engineered Systems
SO PROCEEDINGS OF THE IEEE
LA English
DT Editorial Material
C1 [Zachery, Randy A.] USAF, Res Lab, Guidance & Nav Sect, Munit Directorate, Eglin AFB, FL USA.
[Sastry, Shankar S.] CITRIS Berkeley, Banatao Inst, Berkeley, CA USA.
[Sastry, Shankar S.] MIT, Cambridge, MA 02139 USA.
[Kumar, Vijay] Univ Penn, Dept Mech Engn & Appl Mech, Dept Comp & Informat Sci, Philadelphia, PA 19104 USA.
RP Zachery, RA (reprint author), USA, Res Lab, Army Res Off, Informat Sci Directorate, Durham, NC USA.
NR 0
TC 2
Z9 2
U1 1
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9219
J9 P IEEE
JI Proc. IEEE
PD SEP
PY 2011
VL 99
IS 9
SI SI
BP 1466
EP 1469
DI 10.1109/JPROC.2011.2160108
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA 810LH
UT WOS:000294126300002
ER
PT J
AU Van Sickle, KR
Buck, L
Willis, R
Mangram, A
Truitt, MS
Shabahang, M
Thomas, S
Trombetta, L
Dunkin, B
Scott, D
AF Van Sickle, Kent R.
Buck, Lauren
Willis, Ross
Mangram, Alicia
Truitt, Michael S.
Shabahang, Mohsen
Thomas, Scott
Trombetta, Lee
Dunkin, Brian
Scott, Daniel
TI A multicenter, simulation-based skills training collaborative using
shared GI mentor II systems: results from the Texas association of
surgical skills laboratories (TASSL) flexible endoscopy curriculum
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Assessment; Curriculum; Flexible endoscopy; Simulation; Training;
Virtual reality
ID VIRTUAL-REALITY SIMULATOR; LAPAROSCOPIC SURGERY; COLONOSCOPY;
FUNDAMENTALS; RESIDENTS; EXPERT; TRIAL
AB The Texas Association of Surgical Skills Laboratories (TASSL) is a nonprofit consortium of surgical skills training centers for the accredited surgery residency programs in Texas. A training and research collaborative was forged between TASSL members and Simbionix (Cleveland, OH, USA) to assess the feasibility and efficacy of a multicenter, simulation- and Web-based flexible endoscopy training curriculum using shared GI Mentor II systems.
Two GI Mentor II flexible endoscopy simulators were provided for the study, and four institutions, namely, the University of Texas Health Science Center-San Antonio (UTHSCSA), Texas A & M University (TAMU), Methodist Hospital (MHD), and Brooke Army Medical Center (BAMC), agreed to share them. One additional site, University of Texas Southwestern (UTSW), already owned a device and participated during the study period. Postgraduate years (PGYs) 1 to 4 subjects completed pre- and posttraining questionnaires and one pre- and posttraining trial of Colonoscopy Case Module 1. EndoBubble 1 and 2 tasks with predefined, expert-derived levels were used for training. Pre- and posttesting performance data were recorded on the simulator and by the Global Assessment of Gastrointestinal Endoscopic Skills (GAGES). All study materials were available through the TASSL Web site. Pre- and posttest comparisons were made by paired t-test.
The curriculum was completed successfully by 41 participants from four institutions. The mean number of trials to proficiency was 13 +/- A 10 for EndoBubble 1 and 23 +/- A 16 for EndoBubble 2. Significant improvements from pre- to posttraining were seen in cecal intubation time (229 +/- A 97 vs. 150 +/- A 57 s; p < 0.001), total time (454 +/- A 147 vs. 320 +/- A 115 s; p < 0.001), screening efficiency (85% +/- A 12% vs. 91% +/- A 5%; p < 0.002), GAGES scores (15 vs. 19; p < 0.001), subjects' endoscopy self-rating scores (1.5 +/- A 1.0 vs. 2.7 +/- A 0.6; range, 0-4; p < 0.001), and comfort level with flexible endoscopy skills (3.4 +/- A 3.0 vs. 7.2 +/- A 1.2; range, 0-8; p < 0.001).
The feasibility of sharing educational and training resources among institutions was demonstrated. Likewise, the concept of "mobile simulation" appears to be useful and effective, with three of the four institutions involved successfully in implementing the training curriculum during a fixed period. Additionally, subjects who completed the training demonstrated both subjective and objective improvements in flexible endoscopy skills.
C1 [Van Sickle, Kent R.; Buck, Lauren; Willis, Ross] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
[Mangram, Alicia; Truitt, Michael S.] Methodist Hosp MHD, Dallas, TX USA.
[Shabahang, Mohsen; Thomas, Scott] Texas A&M Univ, Scott & White Clin, Temple, TX USA.
[Trombetta, Lee] Brooke Army Med Ctr, San Antonio, TX USA.
[Dunkin, Brian] Methodist Hosp, Houston, TX 77030 USA.
[Scott, Daniel] Univ Texas SW UTSW, Dallas, TX USA.
RP Van Sickle, KR (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl,Mail Code 7840, San Antonio, TX 78229 USA.
EM sickle@uthscsa.edu
FU Covidien
FX This project was supported through educational grants from Covidien. The
authors thank Simbionix, Inc. for its cooperation and participation in
this study.
NR 17
TC 16
Z9 16
U1 2
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
J9 SURG ENDOSC
JI Surg. Endosc.
PD SEP
PY 2011
VL 25
IS 9
BP 2980
EP 2986
DI 10.1007/s00464-011-1656-7
PG 7
WC Surgery
SC Surgery
GA 811OC
UT WOS:000294219800022
PM 21487880
ER
PT J
AU Satava, RM
Hunter, AM
AF Satava, Richard M.
Hunter, Anne Marie
TI The surgical ensemble: choreography as a simulation and training tool
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Education; Training; Courses; Surgical choreography; Surgical rehearsal
AB Team training and interprofessional training have recently emerged as critical new simulations that enhance performance by coordinating communication, leadership, professional, and, to a certain extent, technical skills. In describing these new training tools, the term choreography has been loosely used, but no critical appraisal of the role of the science of choreography has been applied to a surgical procedure. By analogy, the surgical team, including anesthetists, surgeons, nurses, and technicians, constitutes a complete ensemble, whose physical actions and interactions constitute the "performance of surgery." There are very specific "elements" (tools) that are basic to choreography, such as space, timing, rhythm, energy, cues, transitions, and especially rehearsal. This review explores whether such a metaphor is appropriate and the possibility of applying the science of choreography to the surgical team in the operating theater.
C1 [Satava, Richard M.] Univ Washington, Med Ctr, Dept Surg, Seattle, WA 98195 USA.
[Satava, Richard M.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Hunter, Anne Marie] Robert Louis Stevenson Sch, Dept Fine Arts, Pebble Beach, CA 93953 USA.
RP Satava, RM (reprint author), Univ Washington, Med Ctr, Dept Surg, 1959 Pacific St NE, Seattle, WA 98195 USA.
EM rsatava@u.washington.edu
NR 10
TC 4
Z9 4
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
J9 SURG ENDOSC
JI Surg. Endosc.
PD SEP
PY 2011
VL 25
IS 9
BP 3080
EP 3086
DI 10.1007/s00464-011-1673-6
PG 7
WC Surgery
SC Surgery
GA 811OC
UT WOS:000294219800036
PM 21484530
ER
PT J
AU Leonard, PW
Pollard, CJ
Chavez, DE
Rice, BM
Parrish, DA
AF Leonard, Philip W.
Pollard, Colin J.
Chavez, David E.
Rice, Betsy M.
Parrish, Damon A.
TI 3,6-Bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,4,2,5-dioxadiazene (BNDD): A
Powerful Sensitive Explosive
SO SYNLETT
LA English
DT Article
DE explosives; furazan; heterocycles; nitrogen; oxidation
AB The explosive 3,6-bis(4-nitro-1,2,5-oxadiazol-3-yl)1,4,2,5- dioxadiazene (BNDD) was synthesized by oxidation of the corresponding diamine using hydrogen peroxide in sulfuric acid with sodium tungstate. The product exhibited detonations during sensitivity testing at low insult; the material is shock and friction sensitive. The synthesis of BNDD should only be pursued by knowledgeable researchers exercising extreme caution.
C1 [Leonard, Philip W.; Pollard, Colin J.; Chavez, David E.] Los Alamos Natl Lab, Weap Expt Div, Los Alamos, NM 87545 USA.
[Rice, Betsy M.] USA, Res Lab, Aberdeen, MD 20783 USA.
[Parrish, Damon A.] USN, Res Lab, Struct Matter Lab, Washington, DC 20375 USA.
RP Leonard, PW (reprint author), Los Alamos Natl Lab, Weap Expt Div, POB 1663, Los Alamos, NM 87545 USA.
EM philipl@lanl.gov
FU Joint Munitions Program; U.S. Department of Energy [DE-AC52-06NA25396]
FX The authors would like to thank the Los Alamos National Laboratory
Analytical team, particularly Annie Giambra for Elemental Analysis, Mary
Sandstrom for DSC, and Daniel Preston for impact, friction, and spark
sensitivity testing. This work was funded by the Joint Munitions
Program. Except where indicated, this information has been authored by
employees of the Los Alamos National Security, LLC. (LANS), operator of
the Los Alamos National Laboratory under Contract No. DE-AC52-06NA25396
with the U.S. Department of Energy. Released for unlimited audience:
LA-UR 11-00570.
NR 13
TC 11
Z9 11
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0936-5214
J9 SYNLETT
JI Synlett
PD SEP
PY 2011
IS 14
BP 2097
EP 2099
DI 10.1055/s-0030-1261169
PG 3
WC Chemistry, Organic
SC Chemistry
GA 810WZ
UT WOS:000294161400031
ER
PT J
AU Taylor, ZD
Singh, RS
Bennett, DB
Tewari, P
Kealey, CP
Bajwa, N
Culjat, MO
Stojadinovic, A
Lee, H
Hubschman, JP
Brown, ER
Grundfest, WS
AF Taylor, Zachary D.
Singh, Rahul S.
Bennett, David B.
Tewari, Priyamvada
Kealey, Colin P.
Bajwa, Neha
Culjat, Martin O.
Stojadinovic, Alexander
Lee, Hua
Hubschman, Jean-Pierre
Brown, Elliott R.
Grundfest, Warren S.
TI THz Medical Imaging: in vivo Hydration Sensing
SO IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Biological and medical imaging; clinical instruments; hydration
interactions; medical diagnostics; submillimeter; Terahertz; THz
AB The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at similar to 525 GHz center frequency with similar to 125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.
C1 [Taylor, Zachary D.; Tewari, Priyamvada; Bajwa, Neha] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA.
[Taylor, Zachary D.; Singh, Rahul S.; Bennett, David B.; Tewari, Priyamvada; Kealey, Colin P.; Bajwa, Neha; Culjat, Martin O.; Grundfest, Warren S.] Univ Calif Los Angeles, CASIT, Los Angeles, CA 90095 USA.
[Bennett, David B.] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA.
[Kealey, Colin P.] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA.
[Singh, Rahul S.; Culjat, Martin O.] Univ Calif Los Angeles, Dept Surg, Dept Bioengn, Los Angeles, CA 90095 USA.
[Hubschman, Jean-Pierre] Univ Calif Los Angeles, Dept, Los Angeles, CA 90095 USA.
[Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Stojadinovic, Alexander] Combat Wound Initiat Program, Washington, DC 20307 USA.
[Lee, Hua] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA.
[Brown, Elliott R.] Wright State Univ, Dept Phys, Dayton, OH 45435 USA.
[Grundfest, Warren S.] Univ Calif Los Angeles, Dept Elect Engn, Dept Bioengn, Dept Surg, Los Angeles, CA 90095 USA.
RP Taylor, ZD (reprint author), Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA.
EM zdeis@seas.ucla.edu
FU National Science Foundation [ECCS-801897]; Telemedicine and Advanced
Technology Research Center (TATRC)/Department of Defense
[W81XWH-09-2-001]
FX This work was supported in part by the National Science Foundation under
Grant ECCS-801897. This work was also based in part upon work supported
in part by the Telemedicine and Advanced Funding provided by the
Telemedicine and Advanced Technology Research Center (TATRC)/Department
of Defense under Award W81XWH-09-2-001. Any opinions, findings, and
conclusions or recommendations expressed in this material are those of
the authors and do not necessarily reflect the views of the National
Science Foundation.
NR 141
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Z9 78
U1 4
U2 34
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2156-342X
J9 IEEE T THZ SCI TECHN
JI IEEE Trans. Terahertz Sci. Technol.
PD SEP
PY 2011
VL 1
IS 1
SI SI
BP 201
EP 219
DI 10.1109/TTHZ.2011.2159551
PG 19
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA V28TJ
UT WOS:000208702800018
PM 26085958
ER
PT J
AU Gabrielli, A
Buki, A
Czeiter, E
Schmid, K
Tortella, F
Wang, KK
Hayes, RL
Mondello, S
AF Gabrielli, A.
Buki, A.
Czeiter, E.
Schmid, K.
Tortella, F.
Wang, K. K.
Hayes, R. L.
Mondello, S.
TI BRAIN DAMAGE BIOMARKERS ARE CORRELATED TO BRAIN ISSUE OXYGENATION IN
PATIENTS WITH SEVERE TRAUMATIC BRAIN L A CASE SERIES
SO INTENSIVE CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Gabrielli, A.; Wang, K. K.; Hayes, R. L.; Mondello, S.] Univ Florida, Gainesville, FL USA.
[Buki, A.; Czeiter, E.] Univ Pecs, Pecs, Hungary.
[Schmid, K.; Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Wang, K. K.; Hayes, R. L.; Mondello, S.] Banyan Biomarkers Inc, Alachua, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0342-4642
EI 1432-1238
J9 INTENS CARE MED
JI Intensive Care Med.
PD SEP
PY 2011
VL 37
SU 1
MA 0923
BP S236
EP S236
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA V34JN
UT WOS:000209082801147
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI Our Last Best Chance: The Pursuit of Peace in a Time of Peril
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 US Army War Coll, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD FAL
PY 2011
VL 65
IS 4
BP 688
EP 689
PG 2
WC Area Studies
SC Area Studies
GA V31XJ
UT WOS:000208916000022
ER
PT J
AU Machingal, MA
Corona, BT
Walters, TJ
Kesireddy, V
Koval, CN
Dannahower, A
Zhao, WX
Yoo, JJ
Christ, GJ
AF Machingal, Masood A.
Corona, Benjamin T.
Walters, Thomas J.
Kesireddy, Venu
Koval, Christine N.
Dannahower, Ashley
Zhao, Weixin
Yoo, James J.
Christ, George J.
TI A Tissue-Engineered Muscle Repair Construct for Functional Restoration
of an Irrecoverable Muscle Injury in a Murine Model
SO TISSUE ENGINEERING PART A
LA English
DT Article
ID CONTRACTION-INDUCED INJURY; MAMMALIAN SKELETAL-MUSCLE; ECCENTRIC
CONTRACTIONS; ISOMETRIC CONTRACTIONS; STRENGTH DEFICITS; COUPLING
FAILURE; CA2+ RELEASE; REGENERATION; FORCE; CELL
AB There are no effective clinical treatments for volumetric muscle loss (VML) resulting from traumatic injury, tumor excision, or other degenerative diseases of skeletal muscle. The goal of this study was to develop and characterize a more clinically relevant tissue-engineered muscle repair (TE-MR) construct for functional restoration of a VML injury in the mouse lattissimus dorsi (LD) muscle. To this end, TE-MR constructs developed by seeding rat myoblasts on porcine bladder acellular matrix were preconditioned in a bioreactor for 1 week and implanted in nude mice at the site of a VML injury created by excising 50% of the native LD. Two months postinjury and implantation of TE-MR, maximal tetanic force was similar to 72% of that observed in native LD muscle. In contrast, injured LD muscles that were not repaired, or were repaired with scaffold alone, produced only similar to 50% of native LD muscle force after 2 months. Histological analyses of LD tissue retrieved 2 months after implantation demonstrated remodeling of the TE-MR construct as well as the presence of desmin-positive myofibers, blood vessels, and neurovascular bundles within the TE-MR construct. Overall, these encouraging initial observations document significant functional recovery within 2 months of implantation of TE-MR constructs and provide clear proof of concept for the applicability of this technology in a murine VML injury model.
C1 [Machingal, Masood A.; Corona, Benjamin T.; Kesireddy, Venu; Koval, Christine N.; Dannahower, Ashley; Zhao, Weixin; Yoo, James J.; Christ, George J.] Wake Forest Univ, Baptist Med Ctr, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA.
[Machingal, Masood A.; Yoo, James J.; Christ, George J.] Wake Forest Univ, Sch Biomed Engn & Sci, Virginia Tech, Winston Salem, NC 27157 USA.
[Walters, Thomas J.] USA, Inst Surg Res, San Antonio, TX USA.
RP Christ, GJ (reprint author), Wake Forest Univ, Baptist Med Ctr, Wake Forest Inst Regenerat Med, Richard H Dean Biomed Res Bldg,Room 442, Med Ctr, Winston Salem, NC 27157 USA.
EM gchrist@wfubmc.edu
RI Machingal, Masood Ahammed/F-7827-2012
FU Armed Forces Institute for Regenerative Medicine (DoD)
[W81XWH-08-2-0032]; Department of Defense [USAMRAA ORTP07-07128091];
Geneva Foundation (United States Army Medical Research Material Command)
[W81XWH-09-2-0177]; NIH USPHS [AR05735]
FX This work was supported in part by the Armed Forces Institute for
Regenerative Medicine (DoD Contract # W81XWH-08-2-0032), the Orthopaedic
Trauma Research Program (USAMRAA ORTP07-07128091) of Department of
Defense, Geneva Foundation grant (W81XWH-09-2-0177 awarded to TJW from
the United States Army Medical Research Material Command), and NIH USPHS
grant AR05735. The authors wish to thank Kristian Andersson, Maja Herco,
Sonia Vishwajit, Bimjhana Bishwokarma, and Cathy Mathis for technical
assistance and Dr. Robert Grange and Dr. Karl-Erik Andersson for helpful
comments and suggestions.
NR 53
TC 58
Z9 59
U1 3
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD SEP
PY 2011
VL 17
IS 17-18
BP 2291
EP 2303
DI 10.1089/ten.tea.2010.0682
PG 13
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA 812OV
UT WOS:000294303700016
PM 21548710
ER
PT J
AU Pasiakos, SM
McClung, HL
McClung, JP
Margolis, LM
Andersen, NE
Cloutier, GJ
Pikosky, MA
Rood, JC
Fielding, RA
Young, AJ
AF Pasiakos, Stefan M.
McClung, Holly L.
McClung, James P.
Margolis, Lee M.
Andersen, Nancy E.
Cloutier, Gregory J.
Pikosky, Matthew A.
Rood, Jennifer C.
Fielding, Roger A.
Young, Andrew J.
TI Leucine-enriched essential amino acid supplementation during moderate
steady state exercise enhances postexercise muscle protein synthesis
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; RESISTANCE EXERCISE; ENDURANCE EXERCISE; COMBINED
INGESTION; AEROBIC EXERCISE; DOSE-RESPONSE; YOUNG MEN; RECOVERY;
CARBOHYDRATE; STIMULATION
AB Background: The effects of essential amino acid (EAA) supplementation during moderate steady state (ie, endurance) exercise on postexercise skeletal muscle metabolism are not well described, and the potential role of supplemental leucine on muscle protein synthesis (MPS) and associated molecular responses remains to be elucidated.
Objective: This randomized crossover study examined whether EAA supplementation with 2 different concentrations of leucine affected post-steady state exercise MPS, whole-body protein turnover, and mammalian target of rapamycin 1 (mTORC1) intracellular signaling.
Design: Eight adults completed 2 separate bouts of cycle ergometry [60 min, 60% VO(2)peak (peak oxygen uptake)]. Isonitrogenous (10 g EAA) drinks with different leucine contents [leucine-enriched (L)EAA, 3.5 g leucine; EAA, 1.87 g leucine] were consumed during exercise. MPS and whole-body protein turnover were determined by using primed continuous infusions of [(2)H(5)] phenylalanine and [1-(13)C]leucine. Multiplex and immunoblot analyses were used to quantify mTORC1 signaling.
Results: MPS was 33% greater (P < 0.05) after consumption of L-EAA (0.08 +/- 0.01%/h) than after consumption of EAA (0.06 +/- 0.01%/ h). Whole-body protein breakdown and synthesis were lower (P < 0.05) and oxidation was greater (P < 0.05) after consumption of L-EAA than after consumption of EAA. Regardless of dietary treatment, multiplex analysis indicated that Akt and mammalian target of rapamycin phosphorylation were increased (P < 0.05) 30 min after exercise. Immunoblot analysis indicated that phosphorylation of ribosomal protein S6 and extracellular-signal regulated protein kinase increased (P < 0.05) and phosphorylation of eukaryotic elongation factor 2 decreased (P < 0.05) after exercise but was not affected by dietary treatment.
Conclusion: These findings suggest that increasing the concentration of leucine in an EAA supplement consumed during steady state exercise elicits a greater MPS response during recovery. This trial is registered at clinicaltrials.gov as NCT01366924. Am J Clin Nutr 2011;94:809-18.
C1 [Pasiakos, Stefan M.; McClung, Holly L.; McClung, James P.; Margolis, Lee M.; Andersen, Nancy E.; Pikosky, Matthew A.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Cloutier, Gregory J.; Fielding, Roger A.] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer US Dept Agr, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.
[Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
RP Pasiakos, SM (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304
FU US Department of Agriculture, Agricultural Research Service
[58-1950-7-707]; US Army Medical Research and Material Command
FX This material is based on work supported by the US Department of
Agriculture, Agricultural Research Service, under agreement no.
58-1950-7-707. Any opinions, findings, conclusion, or recommendations
expressed in this publication are those of the authors and do not
necessarily reflect the view of the US Department of Agriculture.;
Supported by the US Army Medical Research and Material Command.
NR 53
TC 35
Z9 37
U1 0
U2 16
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD SEP
PY 2011
VL 94
IS 3
BP 809
EP 818
DI 10.3945/ajcn.111.017061
PG 10
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 809IX
UT WOS:000294047200016
PM 21775557
ER
PT J
AU Ryan, PB
Lee-Wilk, T
Kok, BC
Wilk, JE
AF Ryan, Patricia B.
Lee-Wilk, Terry
Kok, Brian C.
Wilk, Joshua E.
TI Interdisciplinary rehabilitation of mild TBI and PTSD: A case report
SO BRAIN INJURY
LA English
DT Article
DE Concussion; post-concussive symptoms; post-traumatic stress disorder;
veterans; blast injuries; iatrogenic effects
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; PERSISTENT
POSTCONCUSSIVE SYMPTOMS; GOOD OLD DAYS; HEAD-INJURY; VETERANS;
EXPECTATION; PERFORMANCE; ETIOLOGY; HEALTH
AB Background: Prevalence of mild traumatic brain injury (mTBI) or concussion on the battlefield in Iraq/Afghanistan has resulted in its designation as a 'signature injury'. Civilian studies have shown that negative expectations for recovery may lead to worse outcomes. While there is concern that concussion screening procedures in the Veteran's Affairs Healthcare System and the Department of Defence could fuel negative expectations, leading to negative iatrogenic effects, it has been difficult to document this in clinical settings. The aim of this report is to describe the case of a veteran with comorbid mTBI/PTSD with persistent symptoms of unknown aetiology and the effects of provider communications on the patient's recovery.
Methods: Case report of a veteran with reported mTBI, including provider communications, neuropsychological test results and report of functioning after changes in provider messages.
Results: Two-years post-mTBI, the patient attributed cognitive difficulties to his brain injury, but neuropsychological assessment found that his cognitive profile was consistent with psychological rather than neurological dysfunction. After providers systematically emphasized expectations of recovery, the patient's daily functioning improved.
Conclusions: This case illustrates difficulties in mass screening for and treating mTBI. Recommendations for improvement include clinician training in effectively communicating positive expectations of recovery after concussion.
C1 [Ryan, Patricia B.; Lee-Wilk, Terry] Baltimore VA Med Ctr, VA Maryland Hlth Care Syst, Baltimore, MD USA.
[Kok, Brian C.; Wilk, Joshua E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Wilk, JE (reprint author), 503 Robert Grant Dr, Silver Spring, MD 20910 USA.
EM joshua.wilk@amedd.army.mil
RI Schueter, nicos/A-3625-2014
NR 43
TC 9
Z9 9
U1 2
U2 8
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9052
J9 BRAIN INJURY
JI Brain Inj.
PD SEP
PY 2011
VL 25
IS 10
BP 1019
EP 1025
DI 10.3109/02699052.2011.597044
PG 7
WC Neurosciences; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA 801TZ
UT WOS:000293464800013
PM 21812588
ER
PT J
AU Salinas, J
Chung, KK
Mann, EA
Cancio, LC
Kramer, GC
Serio-Melvin, ML
Renz, EM
Wade, CE
Wolf, SE
AF Salinas, Jose
Chung, Kevin K.
Mann, Elizabeth A.
Cancio, Leopoldo C.
Kramer, George C.
Serio-Melvin, Maria L.
Renz, Evan M.
Wade, Charles E.
Wolf, Steven E.
TI Computerized decision support system improves fluid resuscitation
following severe burns: An original study
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE automated systems; burn care; burn resuscitation; computer decision
support; crystalloid infusion; information technology
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; CHILDREN;
FORMULA
AB Objective: Several formulas have been developed to guide resuscitation in severely burned patients during the initial 48 hrs after injury. These approaches require manual titration of fluid that may result in human error during this process and lead to suboptimal outcomes. The goal of this study was to analyze the efficacy of a computerized open-loop decision support system for burn resuscitation compared to historical controls.
Design: Fluid infusion rates and urinary output from 39 severely burned patients with >20% total body surface area burns were recorded upon admission (Model group). A fluid-response model based on these data was developed and incorporated into a computerized open-loop algorithm and computer decision support system. The computer decision support system was used to resuscitate 32 subsequent patients with severe burns (computer decision support system group) and compared with the Model group.
Setting: Burn intensive care unit of a metropolitan Level 1 Trauma center.
Patients: Acute burn patients with >20% total body surface area requiring active fluid resuscitation during the initial 24 to 48
Measurements and Main Results: We found no significant difference between the Model and computer decision support system groups in age, total body surface area, or injury mechanism. Total crystalloid volume during the first 48 hrs post burn, total crystalloid intensive care unit volume, and initial 24-hr crystalloid intensive care unit volume were all lower in the computer decision support system group. Infused volume per kilogram body weight (mL/kg) and per percentage burn (mL/kg/total body surface area) were also lower for the computer decision support system group. The number of patients who met hourly urinary output goals was higher in the computer decision support system group.
Conclusions: Implementation of a computer decision support system for burn resuscitation in the intensive care unit resulted in improved fluid management of severely burned patients. All measures of crystalloid fluid volume were reduced while patients were maintained within urinary output targets a higher percentage of the time. The addition of computer decision support system technology improved patient care. (Crit Care Med 2011; 39: 2031-2038)
C1 [Salinas, Jose; Chung, Kevin K.; Mann, Elizabeth A.; Cancio, Leopoldo C.; Serio-Melvin, Maria L.; Renz, Evan M.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Kramer, George C.] Univ Texas Med Branch, Dept Anesthesiol & Surg, Galveston, TX USA.
[Wade, Charles E.] Univ Texas Hlth Sci Ctr, Houston, TX USA.
RP Salinas, J (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM jose.salinas4@us.army.mil
OI Wolf, Steven/0000-0003-2972-3440
FU National Institutes of Health; U.S. Army
FX Supported, in part, by the National Institutes of Health and the U.S.
Army Combat Casualty Care Research Program.
NR 32
TC 46
Z9 50
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
J9 CRIT CARE MED
JI Crit. Care Med.
PD SEP
PY 2011
VL 39
IS 9
BP 2031
EP 2038
DI 10.1097/CCM.0b013e31821cb790
PG 8
WC Critical Care Medicine
SC General & Internal Medicine
GA 808TH
UT WOS:000294000800003
PM 21532472
ER
PT J
AU Tezvergil-Mutluay, A
Agee, KA
Hoshika, T
Uchiyama, T
Tjaderhane, L
Breschi, L
Mazzoni, A
Thompson, JM
McCracken, CE
Looney, SW
Tay, FR
Pashley, DH
AF Tezvergil-Mutluay, Arzu
Agee, Kelli A.
Hoshika, Tomohiro
Uchiyama, Toshikazu
Tjaderhane, Leo
Breschi, Lorenzo
Mazzoni, Annalisa
Thompson, Jeremy M.
McCracken, Courtney E.
Looney, Stephen W.
Tay, Franklin R.
Pashley, David H.
TI Inhibition of MMPs by alcohols
SO DENTAL MATERIALS
LA English
DT Article
DE Dentin matrix; MMPs; Alcohol; HEMA; Collagen
ID SELF-ETCHING ADHESIVES; 4-YEAR WATER DEGRADATION; DENTIN BOND STRENGTH;
MATRIX METALLOPROTEINASES; IN-VIVO; CHLORHEXIDINE; NANOLEAKAGE;
DURABILITY; COLLAGEN; STABILITY
AB Objectives. While screening the activity of potential inhibitors of matrix metalloproteinases (MMPs), due to the limited water solubility of some of the compounds, they had to be solubilized in ethanol. When ethanol solvent controls were run, they were found to partially inhibit MMPs. Thus, the purpose of this study was to compare the MMP-inhibitory activity of a series of alcohols.
Methods. The possible inhibitory activity of a series of alcohols was measured against soluble rhMMP-9 and insoluble matrix-bound endogenous MMPs of dentin in completely demineralized dentin. Increasing concentrations (0.17, 0.86, 1.71 and 4.28 mol/L) of a homologous series of alcohols (i.e. methanol, ethanol, propanols, butanols, pentanols, hexanols, the ethanol ester of methacrylic acid, heptanols and octanol) were compared to ethanediol, and propanediol by regression analysis to calculate the molar concentration required to inhibit MMPs by 50% (i.e. the IC(50)).
Results. Using two different MMP models, alcohols were shown to inhibit rhMMP-9 and the endogenous proteases of dentin matrix in a dose-dependent manner. The degree of MMP inhibition by alcohols increased with chain length up to 4 methylene groups. Based on the molar concentration required to inhibit rhMMP-9 fifty percent, 2-hydroxyethylmethacrylate (HEMA), 3-hexanol, 3-heptanol and 1-octanol gave the strongest inhibition.
Significance. The results indicate that alcohols with 4 methylene groups inhibit MMPs more effectively than methanol or ethanol. MMP inhibition was inversely related to the Hoy's solubility parameter for hydrogen bonding forces of the alcohols (i.e. to their hydrophilicity). (C) 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
C1 [Tezvergil-Mutluay, Arzu] Univ Turku, Sch Dent, Dept Restorat Dent & Endodont, Turku, Finland.
[Agee, Kelli A.; Tay, Franklin R.; Pashley, David H.] Georgia Hlth Sci Univ, Coll Dent Med, Augusta, GA USA.
[Hoshika, Tomohiro] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Operat Dent, Okayama 7008530, Japan.
[Uchiyama, Toshikazu] Nihon Univ, Sch Dent Matsudo, Dept Renascent Dent, Chiba, Japan.
[Tjaderhane, Leo] Univ Oulu, Inst Dent, Oulu, Finland.
[Tjaderhane, Leo] Oulu Univ Hosp, Oulu, Finland.
[Breschi, Lorenzo] Univ Trieste, IGM, CNR, Dept Biomed,Unit Bologna,IOR, Bologna, Italy.
[Mazzoni, Annalisa] Univ Bologna, Dept SAU & FAL, Bologna, Italy.
[Thompson, Jeremy M.] USA Endodont Residency, Ft Gordon, GA USA.
[McCracken, Courtney E.; Looney, Stephen W.] Georgia Hlth Sci Univ, Dept Biostat, Augusta, GA USA.
RP Pashley, DH (reprint author), Med Georgia, Sch Dent, Dept Oral Biol, 1120 15th St,CL-2112, Augusta, GA 30912 USA.
EM dpashley@mail.mcg.edu
RI Rastelli, Marcio/B-8034-2011; Tjaderhane, Leo/J-5017-2015;
OI Tjaderhane, Leo/0000-0002-5018-478X; Breschi,
Lorenzo/0000-0001-7621-226X
FU National Institute of Dental and Craniofacial Research [R01 DE015306-06,
R21 DE019213-01]; Academy of Finland [8126472]
FX This study was supported in part by grants R01 DE015306-06 (PI. David H.
Pashley), R21 DE019213-01 (PI. Franklin R. Tay) from the National
Institute of Dental and Craniofacial Research and by Grant # 8126472
(PI. Arzu Tezvergil-Mutluay) from Academy of Finland. The authors are
grateful to Mrs. Michelle Barnes for her secretarial support.
NR 37
TC 16
Z9 18
U1 1
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0109-5641
J9 DENT MATER
JI Dent. Mater.
PD SEP
PY 2011
VL 27
IS 9
BP 926
EP 933
DI 10.1016/j.dental.2011.05.004
PG 8
WC Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials
SC Dentistry, Oral Surgery & Medicine; Materials Science
GA 803HA
UT WOS:000293571200009
PM 21676453
ER
PT J
AU Sherburn, JA
Horstemeyer, MF
Bammann, DJ
Baumgardner, JR
AF Sherburn, J. A.
Horstemeyer, M. F.
Bammann, D. J.
Baumgardner, J. R.
TI Two-dimensional mantle convection simulations using an internal state
variable model: the role of a history dependent rheology on mantle
convection
SO GEOPHYSICAL JOURNAL INTERNATIONAL
LA English
DT Article
DE Transient deformation; Mantle processes; Plasticity, diffusion, and
creep; Dynamics: convection currents, and mantle plumes; Rheology:
mantle
ID NUMBER THERMAL-CONVECTION; INFINITE PRANDTL NUMBER; FINITE-DEFORMATION
PLASTICITY; HIGH RAYLEIGH NUMBER; EARTHS MANTLE; NUMERICAL-MODELS;
VISCOSITY; DUNITE; FLOW; LITHOSPHERE
AB We apply the Bammann inelastic internal state variable model (BIISV) to a mantle convection code TERRA2D to investigate the influence of a history dependent solid mechanics model on mantle convection. We compare and contrast the general purpose BIISV model to the commonly used power-law model. We implemented the BIISV model using a radial return algorithm and tested it against previously published mantle convection simulation results for verification. Model constants for the BIISV are used based on experimental stress-strain behaviour found in the literature. After implementation we give illustrative simulation examples were the BIISV produces hardened areas on the cold thermal boundary layer that the power-law model cannot produce. The hardened boundary layers divert material downward giving a plausible reason for the current subduction zones that are present on the Earth.
C1 [Sherburn, J. A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Horstemeyer, M. F.; Bammann, D. J.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA.
[Horstemeyer, M. F.; Bammann, D. J.] Mississippi State Univ, Mississippi State, MS 39762 USA.
[Baumgardner, J. R.] Logos Res Associates, Santa Ana, CA 92704 USA.
RP Sherburn, JA (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jesse.a.sherburn@usace.army.mil
OI Horstemeyer, Mark/0000-0003-4230-0063
NR 45
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0956-540X
J9 GEOPHYS J INT
JI Geophys. J. Int.
PD SEP
PY 2011
VL 186
IS 3
BP 945
EP 962
DI 10.1111/j.1365-246X.2011.05095.x
PG 18
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 808SF
UT WOS:000293998000003
ER
PT J
AU Yu, PL
Sadler, BM
AF Yu, Paul L.
Sadler, Brian M.
TI MIMO Authentication via Deliberate Fingerprinting at the Physical Layer
SO IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY
LA English
DT Article
DE Authentication; fingerprinting; modulation;
multiple-input-multiple-output (MIMO); superimposed signaling
ID CHANNEL ESTIMATION; COVARIANCE; CAPACITY
AB We consider authentication of a wireless multiple-input-multiple-output (MIMO) system by deliberately introducing a stealthy fingerprint at the physical layer. The fingerprint is superimposed onto the data and uniquely conveys an authentication message as a function of the transmitted data and a shared secret key. A symbol synchronous approach to fingerprint embedding provides low complexity operation. In comparison with a conventional tag-based authentication approach, fingerprinting conveys much less information on the secret key to an eavesdropper. We study the trade-offs between stealth, security, and robustness, and show that very good operating points exist. We consider the cases when deterministic or statistical channel state information is available to the transmitter, and show how precoding and channel mode power allocation can be applied to both the data and the fingerprint in combination to enhance the authentication process.
C1 [Yu, Paul L.; Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Yu, PL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM paul.yu@arl.army.mil; bsadler@us.army.mil
NR 19
TC 10
Z9 10
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1556-6013
J9 IEEE T INF FOREN SEC
JI IEEE Trans. Inf. Forensic Secur.
PD SEP
PY 2011
VL 6
IS 3
SI SI
BP 606
EP 615
DI 10.1109/TIFS.2011.2134850
PN 1
PG 10
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA 807TX
UT WOS:000293924000010
ER
PT J
AU Lumsden, JM
Pichyangkul, S
Srichairatanakul, U
Yongvanitchit, K
Limsalakpetch, A
Nurmukhambetova, S
Klein, J
Bertholet, S
Vedvick, TS
Reed, SG
Sattabongkot, J
Bennett, JW
Polhemus, ME
Ockenhouse, CF
Howard, RF
Yadava, A
AF Lumsden, Joanne M.
Pichyangkul, Sathit
Srichairatanakul, Utaiwan
Yongvanitchit, Kosol
Limsalakpetch, Amporn
Nurmukhambetova, Saule
Klein, Jennifer
Bertholet, Sylvie
Vedvick, Thomas S.
Reed, Steven G.
Sattabongkot, Jetsumon
Bennett, Jason W.
Polhemus, Mark E.
Ockenhouse, Christian F.
Howard, Randall F.
Yadava, Anjali
TI Evaluation of the Safety and Immunogenicity in Rhesus Monkeys of a
Recombinant Malaria Vaccine for Plasmodium vivax with a Synthetic
Toll-Like Receptor 4 Agonist Formulated in an Emulsion
SO INFECTION AND IMMUNITY
LA English
DT Article
ID T-CELL RESPONSES; CIRCUMSPOROZOITE-PROTEIN; PRECLINICAL EVALUATION;
FALCIPARUM-MALARIA; DENDRITIC CELLS; PROTECTION; ANTIBODIES; EFFICACY;
TRANSMISSION; IMMUNIZATION
AB Plasmodium vivax is the major cause of malaria outside sub-Saharan Africa and inflicts debilitating morbidity and consequent economic impacts in developing countries. In order to produce a P. vivax vaccine for global use, we have previously reported the development of a novel chimeric recombinant protein, VMP001, based on the circumsporozoite protein (CSP) of P. vivax. Very few adjuvant formulations are currently available for human use. Our interest is to evaluate second-generation vaccine formulations to identify novel combinations of adjuvants capable of inducing strong, long-lasting immune responses. In this study rhesus monkeys were immunized intramuscularly three times with VMP001 in combination with a stable emulsion (SE) or a synthetic Toll-like receptor 4 (TLR4) agonist (glucopyranosyl lipid A [GLA]) in SE (GLA-SE). Sera and peripheral blood mononuclear cells (PBMCs) were tested for the presence of antigen-specific humoral and cellular responses, respectively. All groups of monkeys generated high titers of anti-P. vivax IgG antibodies, as detected by enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence assays. In addition, all groups generated a cellular immune response characterized by antigen-specific CD4(+) T cells secreting predominantly interleukin-2 (IL-2) and lesser amounts of tumor necrosis factor (TNF). We conclude that the combination of VMP001 and GLA-SE is safe and immunogenic in monkeys and may serve as a potential second-generation vaccine candidate against P. vivax malaria.
C1 [Lumsden, Joanne M.; Nurmukhambetova, Saule; Klein, Jennifer; Bennett, Jason W.; Polhemus, Mark E.; Ockenhouse, Christian F.; Yadava, Anjali] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA.
[Pichyangkul, Sathit; Srichairatanakul, Utaiwan; Yongvanitchit, Kosol; Limsalakpetch, Amporn] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Bertholet, Sylvie; Vedvick, Thomas S.; Reed, Steven G.; Howard, Randall F.] Infect Dis Res Inst, Seattle, WA 98104 USA.
[Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
RP Yadava, A (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM anjali.yadava@us.army.mil
RI Bennett, Jason/B-3547-2011
FU U.S. Army Medical Materiel Development Activity; Military Infectious
Diseases Research Program (Fort Detrick, MD); Bill and Melinda Gates
Foundation [42387]
FX This work was supported by the U.S. Army Medical Materiel Development
Activity and the Military Infectious Diseases Research Program (Fort
Detrick, MD) and by grant number 42387 from the Bill and Melinda Gates
Foundation (S.G.R.).
NR 35
TC 20
Z9 21
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD SEP
PY 2011
VL 79
IS 9
BP 3492
EP 3500
DI 10.1128/IAI.05257-11
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 807IV
UT WOS:000293891000002
PM 21690242
ER
PT J
AU Toll, LE
Emanuel, DC
Letowski, T
AF Toll, Laura E.
Emanuel, Diana C.
Letowski, Tomasz
TI Effect of static force on bone conduction hearing thresholds and comfort
SO INTERNATIONAL JOURNAL OF AUDIOLOGY
LA English
DT Article
DE Bone conduction threshold; Static force; Comfort ratings
AB Objective : To assess the effect of the static force of a bone vibrator on the results of bone conduction (BC) threshold measurements and comfort. Design : BC thresholds were determined for 40 participants using the standardized P-3333 headband and a leather adjustable headstrap with variable static forces (2.4, 3.4, 4.4, 5.4 N). Comfort ratings were examined using a five-point Likert scale. Results : Mean BC thresholds were within +/- 2 dB across all conditions; differences may be considered small enough to be clinically insignificant. Participants experienced significantly greater discomfort with the P-3333 versus the adjustable headstrap. The mean static force of the P-3333 varied considerably and was higher in situ than the calibration standard of 5.4 N. Conclusions: The results suggest that future revisions of relevant international and national standards should address the use of an adjustable headstrap and a static force less than 5.4 N.
C1 [Toll, Laura E.] Chesapeake Ear Nose & Throat PA, Owings Mills, MD 21117 USA.
[Emanuel, Diana C.] Towson Univ, Towson, MD USA.
[Letowski, Tomasz] USA, Res Lab Aberdeen Proving Ground, Aberdeen, MD USA.
RP Toll, LE (reprint author), Chesapeake Ear Nose & Throat PA, 23 Crossroads Dr,Suite 400, Owings Mills, MD 21117 USA.
EM lauratollaud@gmail.com
NR 14
TC 6
Z9 7
U1 0
U2 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1499-2027
J9 INT J AUDIOL
JI Int. J. Audiol.
PD SEP
PY 2011
VL 50
IS 9
BP 632
EP 635
DI 10.3109/14992027.2011.568013
PG 4
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA 807SS
UT WOS:000293920600007
PM 21506894
ER
PT J
AU Hisley, DM
Gurganus, JC
Drysdale, AW
AF Hisley, Dixie M.
Gurganus, James C.
Drysdale, Andrew W.
TI Experimental Methodology Using Digital Image Correlation to Assess
Ballistic Helmet Blunt Trauma
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article
DE ballistic impact; combat helmet; back face deformation; blunt criterion;
digital image correlation
AB As modern helmets have become quite capable of defeating the penetration capabilities of ballistic threats, Soldiers may experience head injuries due to blunt trauma caused by helmet back face deformation (BFD). Possible resulting injuries include skull fracture, hematoma, concussion, contusion, diffuse axonal injury, etc. Some of these injuries have been associated with traumatic brain injury. In order to assess potential injury mechanisms prior to fielding new helmets, we have developed a means to experimentally replicate and measure helmet BFD that can be correlated to injury criteria. In this study, helmet performance test methodology is developed using a digital image correlation (DIC) technique. DIC provides the capability to measure dynamic displacements, thereby providing the ability to calculate deformation, velocity, and acceleration rates. We have shown that digital image correlation is an experimentation technique that accurately captures BFD area and rate of deformation for impacts against combat helmets. We used the DIC data to calculate a new metric; the available energy that could potentially impact a Soldier's head. Our study shows that DIC data upholds the hypothesis that helmet BFD mechanically loads the skull similar to a direct impact from a less-than-lethal projectile or blunt object impact. The available energy obtained from DIC measurements was used to calculate the blunt criterion (BC) for helmet standoff distances of 12.7 mm (0.5 in) and 19.1 mm (0.75 in), which in turn can provide a prediction of the probability of abbreviated injury scale (AIS) levels and, in particular, skull fracture. DIC can be used to provide dynamic helmet performance data that will allow increased understanding of BFD and quantitative assessment and validation of helmet performance results. Knowledge of the conditions leading to head trauma obtained through DIC experimentation should enable the selection of new energy-absorbing materials for helmets; thus, allowing new helmet design candidate performances to be objectively evaluated. Test data and characterization of helmet response could then be used to achieve improved warfighter survivability. [DOI: 10.1115/1.4004332]
C1 [Hisley, Dixie M.; Gurganus, James C.; Drysdale, Andrew W.] USA, Res Lab, Syst Engn & Experimentat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Hisley, DM (reprint author), USA, Res Lab, Syst Engn & Experimentat Branch, Aberdeen Proving Ground, MD 21005 USA.
EM dixie.hisley@us.army.mil; james.gurganus@us.army.mil;
andrew.drysdale@us.army.mil
FU Survivability and Lethality Analysis Directorate of the Army Research
Laboratory
FX Funding for this research was provided by the TILV program,
Survivability and Lethality Analysis Directorate of the Army Research
Laboratory. The authors would also like to acknowledge the efforts of
Scott Williams and Joseph Lee in the completion of this work. This
material is declared a work of the U. S. Government and is not subject
to copyright protection in the United States. Approved for public
release; distribution is unlimited.
NR 15
TC 5
Z9 5
U1 1
U2 12
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD SEP
PY 2011
VL 78
IS 5
AR 051022
DI 10.1115/1.4004332
PG 7
WC Mechanics
SC Mechanics
GA 806GT
UT WOS:000293795000022
ER
PT J
AU Gwinn, DE
Tintle, SM
Kumar, AR
Andersen, RC
Keeling, JJ
AF Gwinn, David E.
Tintle, Scott M.
Kumar, Anand R.
Andersen, Romney C.
Keeling, John J.
TI Blast-Induced Lower Extremity Fractures With Arterial Injury: Prevalence
and Risk Factors for Amputation After Initial Limb-Preserving Treatment
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE blast trauma; amputation; limb salvage; arterial injury; wartime injury
ID OPERATION-IRAQI-FREEDOM; OPEN TIBIAL FRACTURES; FREE TISSUE TRANSFER;
THREATENING INJURIES; VASCULAR INJURY; SEVERITY SCORE; TRAUMA; SALVAGE;
RECONSTRUCTION; MANAGEMENT
AB Objectives: The purpose of this study is to determine the rate of late (secondary) amputation and to identify risk factors for amputation in injuries that were initially treated with limb preservation on the battlefield.
Methods: A retrospective review at our institution identified 24 consecutive patients with 26 blast-induced open fractures distal to the joint that had associated arterial injuries. All injuries were initially cared for on the battlefield and during the evacuation chain of care with limb preservation protocols. All definitive orthopaedic care was provided by a single fellowship-trained orthopaedic trauma surgeon at a tertiary care stateside facility. Injury factors were analyzed based on radiographic and chart review to determine associations with amputation.
Results: Twenty of 26 injured limbs received an amputation for a total amputation rate of 76.9% (95% confidence interval, 57.9-88.9%). Fourteen limbs received early amputation before limb salvage attempts. Six of the 12 limbs that received limb salvage underwent late amputation.
Conclusions: The rate of amputation in severe blast-induced extremity fractures combined with an arterial injury initially treated with limb preservation on the battlefield and before transfer to the definitive military treatment facility is extremely high. Blast-injured lower limbs with a combined severe bony and soft tissue injury should be carefully assessed when arterial injury is present because they may require early amputation during initial surgical care on the battlefield.
C1 [Gwinn, David E.] Natl Naval Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthoped Surg Serv, Bethesda, MD 20889 USA.
[Andersen, Romney C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Kumar, Anand R.] Natl Naval Med Ctr, Dept Plast Surg, Bethesda, MD 20889 USA.
RP Gwinn, DE (reprint author), Natl Naval Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthoped Surg Serv, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM gwinny13@yahoo.com
NR 33
TC 4
Z9 4
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2011
VL 25
IS 9
BP 543
EP 548
DI 10.1097/BOT.0b013e3181fc6062
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 809LY
UT WOS:000294058900016
PM 21654527
ER
PT J
AU Waldron, BL
Jensen, KB
Palazzo, AJ
Cary, TJ
Robins, JG
Peel, MD
Ogle, DG
St John, L
AF Waldron, Blair L.
Jensen, Kevin B.
Palazzo, Antonio J.
Cary, Timothy J.
Robins, Joseph G.
Peel, Michael D.
Ogle, Daniel G.
St John, Loren
TI 'Recovery', a New Western Wheatgrass Cultivar with Improved Seedling
Establishment on Rangelands
SO JOURNAL OF PLANT REGISTRATIONS
LA English
DT Article
ID CRESTED WHEATGRASS; REGISTRATION; II.
AB 'Recovery' western wheatgrass [Pascopyrum smithii (Rydb.) Barkworth & D. R. Dewy] (Reg. No. CV-32, PI 660509) was released in December 2009 by the USDA-ARS, the Engineer Research and Development Center of the U. S. Army Corps of Engineers, and the USDA-NRCS. Recovery was developed for reseeding rangelands following severe disturbance, frequent fires, and soil erosion, and it was selected with emphasis on improved and faster seedling establishment. Recovery was evaluated as TC3, TC-Rich, Army WWG, SERDP WWG, and NRCS-9076517 and was developed as a synthetic cultivar using two cycles of recurrent selection for plant vigor, seed yield, and rate of seedling emergence from a deep planting depth. In field evaluations, Recovery had an increased frequency of seedlings during the establishment year, when averaged across eight locations, than 'Arriba', 'Barton', 'Flintlock', 'Rodan', and 'Rosana' western wheatgrasses. Recovery continued to have superior stand until 4-6 yr after planting, when due to their rhizomatous nature, all the western wheatgrasses had similar stand frequencies. Recovery western wheatgrass provides land managers with a new western wheatgrass cultivar possessing rapid establishment for use in areas that are frequently disturbed, such as military training lands. The use of Recovery will help reduce soil erosion and weed invasion following such disturbances.
C1 [Waldron, Blair L.; Jensen, Kevin B.; Robins, Joseph G.; Peel, Michael D.] USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA.
[Palazzo, Antonio J.; Cary, Timothy J.] USA, Corps Engineers Engn Res & Dev Ctr, Hanover, NH 03755 USA.
[Ogle, Daniel G.] USDA NRCS, Boise, ID 83709 USA.
[St John, Loren] USDA NRCS, Aberdeen Plant Mat Ctr, Aberdeen, ID 83210 USA.
RP Waldron, BL (reprint author), USDA ARS, Forage & Range Res Lab, 696 North,1100 East, Logan, UT 84322 USA.
EM blair.waldron@ars.usda.gov
FU Strategic Environmental Research and Development Program (SERDP)
[CS1103]
FX The authors gratefully acknowledge the Strategic Environmental Research
and Development Program (SERDP) Project CS1103, "Identify Resilient
Plant Characteristics and Develop Wear-resistant Plant Cultivar for Use
on Military Training Lands," for support of this project.
NR 15
TC 2
Z9 3
U1 0
U2 4
PU CROP SCIENCE SOC AMER
PI MADISON
PA 677 S SEGOE ROAD, MADISON, WI 53711 USA
SN 1936-5209
J9 J PLANT REGIST
JI J. Plant Regist.
PD SEP
PY 2011
VL 5
IS 3
BP 367
EP 373
DI 10.3198/jpr2010.09.0527crc
PG 7
WC Agronomy; Plant Sciences
SC Agriculture; Plant Sciences
GA 802OO
UT WOS:000293521100019
ER
PT J
AU Radoshitzky, SR
Warfield, KL
Chi, XL
Dong, L
Kota, K
Bradfute, SB
Gearhart, JD
Retterer, C
Kranzusch, PJ
Misasi, JN
Hogenbirk, MA
Wahl-Jensen, V
Volchkov, VE
Cunningham, JM
Jahrling, PB
Aman, MJ
Bavari, S
Farzan, M
Kuhn, JH
AF Radoshitzky, Sheli R.
Warfield, Kelly L.
Chi, Xiaoli
Dong, Lian
Kota, Krishna
Bradfute, Steven B.
Gearhart, Jacqueline D.
Retterer, Cary
Kranzusch, Philip J.
Misasi, John N.
Hogenbirk, Marc A.
Wahl-Jensen, Victoria
Volchkov, Viktor E.
Cunningham, James M.
Jahrling, Peter B.
Aman, M. Javad
Bavari, Sina
Farzan, Michael
Kuhn, Jens H.
TI Ebolavirus Delta-Peptide Immunoadhesins Inhibit Marburgvirus and
Ebolavirus Cell Entry
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID ANGIOTENSIN-CONVERTING ENZYME-2; SMALL GLYCOPROTEIN SGP; VIRUS
GLYCOPROTEIN; ENDOSOMAL CATHEPSINS; ELECTRON-MICROSCOPY; SARS
CORONAVIRUS; VIRAL ENTRY; RECEPTOR; SEQUENCE; MEMBRANE
AB With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and "cuevaviruses") cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP(1,2), to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion. In addition to GP(1,2), ebolaviruses and cuevaviruses, but not marburgviruses, express two secreted glycoproteins, soluble GP (sGP) and small soluble GP (ssGP). All three glycoproteins have identical N termini that include the receptor-binding region (RBR) but differ in their C termini. We evaluated the effect of the secreted ebolavirus glycoproteins on marburgvirus and ebolavirus cell entry, using Fc-tagged recombinant proteins. Neither sGP-Fc nor ssGP-Fc bound to filovirus-permissive cells or inhibited GP(1,2)-mediated cell entry of pseudotyped retroviruses. Surprisingly, several Fc-tagged Delta-peptides, which are small C-terminal cleavage products of sGP secreted by ebolavirus-infected cells, inhibited entry of retroviruses pseudotyped with Marburg virus GP(1,2), as well as Marburg virus and Ebola virus infection in a dose-dependent manner and at low molarity despite absence of sequence similarity to filovirus RBRs. Fc-tagged Delta-peptides from three ebolaviruses (Ebola virus, Sudan virus, and Ta Forest virus) inhibited GP(1,2)-mediated entry and infection of viruses comparably to or better than the Fc-tagged RBRs, whereas the Delta-peptide-Fc of an ebolavirus nonpathogenic for humans (Reston virus) and that of an ebolavirus with lower lethality for humans (Bundibugyo virus) had little effect. These data indicate that Delta-peptides are functional components of ebolavirus proteomes. They join cathepsins and integrins as novel modulators of filovirus cell entry, might play important roles in pathogenesis, and could be exploited for the synthesis of powerful new antivirals.
C1 [Wahl-Jensen, Victoria; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
[Radoshitzky, Sheli R.; Warfield, Kelly L.; Chi, Xiaoli; Dong, Lian; Kota, Krishna; Bradfute, Steven B.; Gearhart, Jacqueline D.; Retterer, Cary; Aman, M. Javad; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Radoshitzky, Sheli R.; Kranzusch, Philip J.; Hogenbirk, Marc A.; Farzan, Michael; Kuhn, Jens H.] Harvard Univ, New England Primate Res Ctr, Sch Med, Southborough, MA 01772 USA.
[Warfield, Kelly L.; Aman, M. Javad] Integrated BioTherapeut Inc, Germantown, MD 20876 USA.
[Misasi, John N.; Cunningham, James M.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
[Hogenbirk, Marc A.] Univ Utrecht, Eijkman Grad Sch Immunol & Infect Dis, NL-3508 TC Utrecht, Netherlands.
[Volchkov, Viktor E.] Univ Lyon 1, Ecole Normale Super Lyon, INSERM, U758, F-69365 Lyon, France.
[Kuhn, Jens H.] Free Univ Berlin, Dept Biol, D-14195 Berlin, Germany.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov
RI Kuhn, Jens H./B-7615-2011; Volchkov, Viktor/M-7846-2014
OI Kuhn, Jens H./0000-0002-7800-6045; Volchkov, Viktor/0000-0001-7896-8706
FU NIAID [HHSN272200200016I]; NERCE/BEID, Boston, MA [AI057159]; Agence
Nationale de la Recherche [ANR-07-MIME-006-01]
FX J.H.K. and V.W.-J. performed part of this work as employees of Tunnell
Consulting, Inc., a subcontractor to Battelle Memorial Institute, under
its prime contract with NIAID (contract HHSN272200200016I). NERCE/BEID,
Boston, MA, provided a Career Development Fellowship to J.H.K. (grant
AI057159). Agence Nationale de la Recherche supported V. E. V.
(ANR-07-MIME-006-01).
NR 60
TC 22
Z9 25
U1 0
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD SEP
PY 2011
VL 85
IS 17
BP 8502
EP 8513
DI 10.1128/JVI.02600-10
PG 12
WC Virology
SC Virology
GA 804AO
UT WOS:000293626100005
PM 21697477
ER
PT J
AU Hwang, SH
Yi, TW
Cho, KH
Lee, IM
Yoon, CS
AF Hwang, S. H.
Yi, T. W.
Cho, K. H.
Lee, I. M.
Yoon, C. S.
TI Testing the performance of microbiological safety cabinets used in
microbiology laboratories in South Korea
SO LETTERS IN APPLIED MICROBIOLOGY
LA English
DT Article
DE microbial worker; microbiological safety cabinet; performance test
ID BRITISH CLINICAL LABORATORIES
AB Aims: To test a performance of the microbiological safety cabinets (MSCs) according to the type of MSCs in microbial laboratories.
Methods and Results: Tests were carried out to assess the performance of 31 MSCs in 14 different facilities, including six different biological test laboratories in six hospitals and eight different laboratories in three universities. The following tests were performed on the MSCs: the downflow test, intake velocity test, high-efficiency particulate air filter leak test and the airflow smoke pattern test. These performance tests were carried out in accordance with the standard procedures. Only 23% of Class II A1 (8), A2 (19) and unknown MSCs (4) passed these performance tests. The main reasons for the failure of MSCs were inappropriate intake velocity (65%), leakage in the HEPA filter sealing (50%), unbalanced airflow smoke pattern in the cabinets (39%) and inappropriate downflow (27%).
Conclusions: This study showed that routine checks of MSCs are important to detect and strengthen the weak spots that frequently develop, as observed during the evaluation of the MSCs of various institutions.
Significance and Impact of the Study: Routine evaluation and maintenance of MSCs are critical for optimizing performance.
C1 [Yoon, C. S.] Seoul Natl Univ, Sch Publ Hlth, Dept Environm Hlth, Inst Hlth & Environm,Environm Hlth Lab, Seoul 151742, South Korea.
[Yi, T. W.] US Army Force Hlth Protect & Prevent Med Ind Hyg, Seoul, South Korea.
[Cho, K. H.] Federat Korean Trade Unions, Seoul, South Korea.
[Lee, I. M.] Inha Univ, Dept Chem Engn & Chem, Inchon, South Korea.
RP Yoon, CS (reprint author), Seoul Natl Univ, Sch Publ Hlth, Dept Environm Hlth, Inst Hlth & Environm,Environm Hlth Lab, Gwanak 599, Seoul 151742, South Korea.
EM csyoon@snu.ac.kr
FU Korea government (MEST) [2010-0029174]
FX This work was supported by the National Research Foundation of Korea
(NRF) grant funded by the Korea government (MEST) (No.2010-0029174).
NR 9
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0266-8254
J9 LETT APPL MICROBIOL
JI Lett. Appl. Microbiol.
PD SEP
PY 2011
VL 53
IS 3
BP 371
EP 373
DI 10.1111/j.1472-765X.2011.03101.x
PG 3
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 807QM
UT WOS:000293914800018
PM 21679200
ER
PT J
AU Swanberg, KM
Clark, AM
Kline, JE
Yurkiewicz, IR
Chan, BL
Pasquina, PF
Heilman, KM
Tsao, JW
AF Swanberg, Kelley M.
Clark, Abigail M.
Kline, Julia E.
Yurkiewicz, Ilana R.
Chan, Brenda L.
Pasquina, Paul F.
Heilman, Kenneth M.
Tsao, Jack W.
TI Enhanced Left-Finger Deftness Following Dominant Upper- and Lower-Limb
Amputation
SO NEUROREHABILITATION AND NEURAL REPAIR
LA English
DT Article
DE dexterity; deftness; amputation; nondominant hand
ID TRANSCRANIAL MAGNETIC STIMULATION; REORGANIZATION; HAND; MOVEMENTS;
HUMANS; MONKEY; STROKE; SYSTEM
AB Background. After amputation, the sensorimotor cortex reorganizes, and these alterations might influence motor functions of the remaining extremities. Objective. The authors examined how amputation of the dominant or nondominant upper or lower extremity alters deftness in the intact limbs. Methods. The participants were 32 unilateral upper-or lower-extremity amputees and 6 controls. Upper-extremity deftness was tested by coin rotation (finger deftness) and pegboard (arm, hand, and finger deftness) tasks. Results. Following right-upper-or right-lower-extremity amputation, the left hand's finger movements were defter than the left-hand fingers of controls. In contrast, with left-upper-or left-lower-extremity amputation, the right hand's finger performance was the same as that of the controls. Conclusions. Although this improvement might be related to increased use (practice), the finding that right-lower-extremity amputation also improved the left hand's finger deftness suggests an alternative mechanism. Perhaps in right-handed persons the left motor cortex inhibits the right side of the body more than the right motor cortex inhibits the left side, and the physiological changes induced by right-sided amputation reduced this inhibition.
C1 [Tsao, Jack W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
[Kline, Julia E.; Yurkiewicz, Ilana R.; Pasquina, Paul F.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Heilman, Kenneth M.] Univ Florida, Gainesville, FL USA.
[Heilman, Kenneth M.] Malcom Randall Vet Affairs Med Ctr, Gainesville, FL USA.
RP Tsao, JW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd,Room A1036, Bethesda, MD 20814 USA.
EM jtsao@usuhs.mil
NR 17
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1545-9683
J9 NEUROREHAB NEURAL RE
JI Neurorehabil. Neural Repair
PD SEP
PY 2011
VL 25
IS 7
BP 680
EP 684
DI 10.1177/1545968311404242
PG 5
WC Clinical Neurology; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA 802LL
UT WOS:000293512500011
PM 21478497
ER
PT J
AU Hamilton, LR
Cox, DM
Myers, TM
AF Hamilton, L. R.
Cox, D. M.
Myers, T. M.
TI OBJECTIVE OPERANT PERFORMANCE HELPED GUIDE AND EVALUATE MEDICAL
TREATMENT IN AN ADULT MALE CYNOMOLGUS MACAQUE
SO AMERICAN JOURNAL OF PRIMATOLOGY
LA English
DT Meeting Abstract
CT 34th Annual Meeting of the American-Society-of-Primatologists
CY SEP 16-19, 2011
CL Austin, TX
SP Amer Soc Primatol
C1 [Hamilton, L. R.; Myers, T. M.] USA, Neurobehav Toxicol Branch, Analyt Toxicol Div, Res Support Div,Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
[Cox, D. M.] USA, Vet Med & Surg Branch, Res Support Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0275-2565
J9 AM J PRIMATOL
JI Am. J. Primatol.
PD SEP
PY 2011
VL 73
SU 1
MA 227
BP 108
EP 108
PG 1
WC Zoology
SC Zoology
GA 805XO
UT WOS:000293764600228
ER
PT J
AU Price, JA
Rogers, JV
Wendling, MQS
Plahovinsak, JL
Perry, MR
Reid, FM
Kiser, RC
Graham, JS
AF Price, Jennifer A.
Rogers, James V.
Wendling, Morgan Q. S.
Plahovinsak, Jennifer L.
Perry, Mark R.
Reid, Frances M.
Kiser, Robyn C.
Graham, John S.
TI Temporal effects in porcine skin following bromine vapor exposure
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE Bromine; skin; porcine; microarray
ID SULFUR MUSTARD; GENE-EXPRESSION; HEME OXYGENASE-1; CHEMOKINE RECEPTORS;
CHEMICAL BURNS; ENDOTHELIAL SELECTINS; HUMAN KERATINOCYTES; MICROARRAY
ANALYSIS; WEANLING SWINE; HIV-INFECTION
AB Bromine is an industrial chemical that causes severe cutaneous burns. When selecting or developing effective treatments for bromine burns, it is important to understand the molecular mechanisms of tissue damage and wound healing. This study investigated the effect of cutaneous bromine vapor exposure on gene expression using a weanling swine burn model by microarray analysis. Ventral abdominal sites were exposed to a mean calculated bromine vapor concentration of 0.51 g/L for 7 or 17 min. At 6 h, 48 h, and 7 days post-exposure, total RNA from skin samples was isolated, processed, and analyzed with Affymetrix GeneChip (R) Porcine Genome Arrays (N = 3 per experimental group). Differences in gene expression were observed with respect to exposure duration and sampling time. Ingenuity Pathways Analysis (IPA) revealed four common biological functions (cancer, cellular movement, cell-to-cell signaling and interaction, and tissue development) among the top ten functions of each experimental group, while canonical pathway analysis revealed 9 genes (ARG2, CCR1, HMOX1, ATF2, IL-8, TIMP1, ESR1, HSPAIL, and SELE) that were commonly shared among four significantly altered signaling pathways. Among these, the transcripts encoding HMOX1 and ESR1 were identified using IPA as common potential therapeutic targets for Phase II/III clinical trial or FDA-approved drugs. The present study describes the transcriptional responses to cutaneous bromine vapor exposure identifying molecular networks and genes that could serve as targets for developing therapeutics for bromine-induced skin injury.
C1 [Price, Jennifer A.; Rogers, James V.; Wendling, Morgan Q. S.; Plahovinsak, Jennifer L.; Perry, Mark R.; Reid, Frances M.; Kiser, Robyn C.] Battelle Biomed Res Ctr, Columbus, OH 43201 USA.
[Graham, John S.] USA, Med Res Inst Chem Def, Program Strategies, Aberdeen Proving Ground, MD 21010 USA.
[Graham, John S.] USA, Med Res Inst Chem Def, Operat Off, Aberdeen Proving Ground, MD 21010 USA.
RP Price, JA (reprint author), Battelle Biomed Res Ctr, 505 King Ave,JM 7, Columbus, OH 43201 USA.
EM priceja@battelle.org
FU DTRA/CBMS/MRMC [W81XWH-05-D-0001]; U.S. Army Medical Research Institute
of Chemical Defense (USAMRICD); National Institutes of Health, National
Institute of Allergies and Infectious Disease (NIAID) [Y1-AI-6177-02]
FX This work was conducted under DTRA/CBMS/MRMC Contract W81XWH-05-D-0001,
Task Order 0010 with funding support through an Interagency Agreement
(IAA) between the U.S. Army Medical Research Institute of Chemical
Defense (USAMRICD) and National Institutes of Health, National Institute
of Allergies and Infectious Disease (NIAID), IAA Number Y1-AI-6177-02.
We thank James Mann, Amy Simmons, and Beth Reed for their excellent
technical assistance. The views, opinions, and/or findings contained in
this report are those of the authors and should not be construed as an
official Department of the Army position, policy, or decision unless so
designated by other documentation. The experimental protocol was
approved by the Animal Care and Use Committee at Battelle Memorial
Institute and the US Army Medical Research and Materiel Command's Animal
Care and Use Review Office. All procedures were conducted in accordance
with the principles stated in the Guide for the Care and Use of
Laboratory Animals (National Research Council, 1996), and the Animal
Welfare Act of 1966 (P.L. 89-544), as amended.
NR 55
TC 2
Z9 2
U1 1
U2 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1556-9527
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD SEP
PY 2011
VL 30
IS 3
BP 187
EP 197
DI 10.3109/15569527.2010.546003
PG 11
WC Ophthalmology; Toxicology
SC Ophthalmology; Toxicology
GA 803SN
UT WOS:000293601200002
PM 21231885
ER
PT J
AU Steele, SR
Maykel, JA
Johnson, EK
AF Steele, Scott R.
Maykel, Justin A.
Johnson, Eric K.
TI Traumatic Injury of the Colon and Rectum: The Evidence vs Dogma
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Traumatic injury; Injury management; Colorectum; Morbidity; Mortality
ID PENETRATING ABDOMINAL-TRAUMA; PRACTICE MANAGEMENT GUIDELINES; DIAGNOSTIC
PERITONEAL-LAVAGE; DAMAGE CONTROL LAPAROTOMY; OPERATION IRAQI FREEDOM;
HOLLOW VISCUS INJURY; CONTRAST HELICAL CT; PRIMARY REPAIR; COLOSTOMY
CLOSURE; PRIMARY ANASTOMOSIS
AB BACKGROUND: The treatment of traumatic injuries to the colon and rectum is often driven by dogma, despite the presence of evidence suggesting alternative methods of care.
OBJECTIVE: This is an evidence-based review, in the format of a review article, to determine the ideal treatment of noniatrogenic traumatic injuries to the colon and rectum to improve the care provided to this group of patients. Recommendations and treatment algorithms were based on consensus conclusions of the data.
DATA SOURCES: A search of MEDLINE, PubMed, and the Cochrane Database of Collected Reviews was performed from 1965 through December 2010.
STUDY SELECTION: Authors independently reviewed selected abstracts to determine their scientific merit and relevance based on key-word combinations regarding colorectal trauma. A directed search of the embedded references from the primary articles was also performed in select circumstances. We then performed a complete evaluation of 108 articles and 3 additional abstracts.
MAIN OUTCOME MEASURES: The main outcomes were morbidity, mortality, and colostomy rates.
RESULTS: Evidence-based recommendations and algorithms are presented for the management of traumatic colorectal injuries.
LIMITATIONS: Level I and II evidence was limited.
CONCLUSIONS: Colorectal injuries remain a challenging clinical entity associated with significant morbidity. Familiarity with the different methods to approach and manage these injuries, including "damage control" tactics when necessary, will allow surgeons to minimize unnecessary complications and mortality.
C1 [Steele, Scott R.] Madigan Army Med Ctr, USUHS, Dept Surg, Ft Lewis, WA USA.
[Maykel, Justin A.] Univ Massachusetts, Sch Med, Mem Med Ctr, Dept Surg, Worcester, MA USA.
[Johnson, Eric K.] Eisenhower Army Med Ctr, USUHS, Dept Surg, Ft Gordon, GA USA.
RP Steele, SR (reprint author), 9606 Piperhill Dr SE, Olympia, WA 98513 USA.
EM harkersteele@gmail.com
NR 111
TC 13
Z9 13
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0012-3706
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD SEP
PY 2011
VL 54
IS 9
BP 1184
EP 1201
DI 10.1007/DCR.0b013e3182188a60
PG 18
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA 804YM
UT WOS:000293691700023
PM 21825901
ER
PT J
AU Ohta, M
Boddu, VM
Uchimiya, M
Sada, K
AF Ohta, Masahiko
Boddu, Veera M.
Uchimiya, Minori
Sada, Kazuki
TI Thermal response and recyclability of poly(stearylacrylate-co-ethylene
glycol dimethacrylate) gel as a VOCs absorbent
SO POLYMER BULLETIN
LA English
DT Article
DE Stearylacrylate (Octadecylacrylate); Volatile organic compounds (VOCs);
Swelling behavior; Absorbent matrix; Volume phase transition
ID INTERPENETRATING POLYMER NETWORKS; ORGANIC-SOLVENTS; HYDROGELS; SORBENTS
AB The development of absorbent materials for volatile organic compounds (VOCs) is in demand for a variety of environmental applications including protective barriers for VOCs point sources. One of the challenges for the currently available VOCs absorbents is their recyclability. In this study, we synthesized poly(stearylacrylate-co-ethylene glycol dimethacrylate) (NG-18) gels, and after rigorous characterization, investigated the absorption properties for VOCs. The synthesized gel could be recycled by immersing in ether and other chlorinated, aromatic, and aliphatic solvents and by cooling them at 0 A degrees C. These recycling processes resulted in approximately 25% weight loss compared to the fully swollen state, due to the crystallization of long-alkyl chain component of the gel. This property shows the possibility of recycling absorbed solvents easily and its usefulness as VOCs absorbent material.
C1 [Ohta, Masahiko; Boddu, Veera M.] US Army Engineer Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Ohta, Masahiko; Sada, Kazuki] Hokkaido Univ, Dept Chem, Grad Sch Sci, Sapporo, Hokkaido 0600810, Japan.
[Uchimiya, Minori] ARS, USDA, So Reg Res Ctr, New Orleans, LA 70124 USA.
RP Boddu, VM (reprint author), US Army Engineer Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab, Champaign, IL 61822 USA.
EM veera.boddu@usace.army.mil
FU Strategic Environmental Research and Development Program (SERDP), USA
[WP-1761]
FX Funding for this research is provided by the Strategic Environmental
Research and Development Program (SERDP), USA, under the project number
WP-1761.
NR 19
TC 6
Z9 6
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0170-0839
EI 1436-2449
J9 POLYM BULL
JI Polym. Bull.
PD SEP
PY 2011
VL 67
IS 5
BP 915
EP 926
DI 10.1007/s00289-011-0514-z
PG 12
WC Polymer Science
SC Polymer Science
GA 804DU
UT WOS:000293635200013
ER
PT J
AU Shackman, AJ
Maxwell, JS
McMenamin, BW
Fox, AS
Greischar, LL
Davidson, RJ
AF Shackman, Alexander J.
Maxwell, Jeffrey S.
McMenamin, Brenton W.
Fox, Andrew S.
Greischar, Lawrence L.
Davidson, Richard J.
TI NEURAL CIRCUITRY MEDIATING THE IMPACT OF ANXIETY ON COGNITION
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 51st Annual Meeting of the Society-of-Psychophysiological-Research
CY SEP 14-18, 2011
CL Boston, MA
SP Soc Psychophysiol Res
C1 [Shackman, Alexander J.; Fox, Andrew S.; Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Madison, WI 53706 USA.
[Maxwell, Jeffrey S.] USA, Human Res Engn Directorate 3, Res Lab, Washington, DC USA.
[McMenamin, Brenton W.] Univ Minnesota Twin Cities, Minneapolis, MN USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2011
VL 48
SU 1
SI SI
BP S8
EP S8
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 800TE
UT WOS:000293389200038
ER
PT J
AU Zhou, J
Enewold, L
Stojadinovic, A
Clifton, GT
Potter, JF
Peoples, GE
Zhu, KM
AF Zhou, Jing
Enewold, Lindsey
Stojadinovic, Alexander
Clifton, Guy T.
Potter, John F.
Peoples, George E.
Zhu, Kangmin
TI Incidence rates of exocrine and endocrine pancreatic cancers in the
United States (vol 21, pg 853, 2010)
SO CANCER CAUSES & CONTROL
LA English
DT Correction
C1 [Zhou, Jing; Enewold, Lindsey; Potter, John F.; Zhu, Kangmin] US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Clifton, Guy T.; Peoples, George E.] Brooke Army Med Ctr, Houston, TX 78234 USA.
[Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
RP Zhu, KM (reprint author), US Mil Canc Inst, Walter Reed Army Med Ctr, Bldg 1,Suite A-109,6900 Georgia Ave NW, Washington, DC 20307 USA.
EM kangmin.zhu@amedd.army.mil
NR 1
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-5243
J9 CANCER CAUSE CONTROL
JI Cancer Causes Control
PD SEP
PY 2011
VL 22
IS 9
BP 1353
EP 1353
DI 10.1007/s10552-011-9816-6
PG 1
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 799OO
UT WOS:000293296200014
ER
PT J
AU Pavelites, JJ
Prahlow, JA
AF Pavelites, Joseph J.
Prahlow, Joseph A.
TI Fatal human monocytic ehrlichiosis: a case study
SO FORENSIC SCIENCE MEDICINE AND PATHOLOGY
LA English
DT Article
DE Ehrlichia chaffeensis; Ehrlichiosis; Forensic pathology;
Immunohistochemistry; PCR; Tick-borne diseases
ID CHAFFEENSIS; DIAGNOSIS
AB Human ehrlichiosis is the term for a collection of tick-borne diseases caused primarily by obligate intracellular bacteria of the Ehrlichia species. Ehrlichiosis is characterized by a mild to severe illness, with approximately 3-5% of cases proving fatal despite receiving appropriate care. This report presents the case of a 60 year-old woman who was found collapsed and unresponsive in her home after an indeterminate time; possibly for up to 48 h. Despite rigorous resuscitative care and antibiotic treatment, the patient lapsed into multi-organ failure and died. Subsequent analysis by microscopic examination, PCR and immunohistochemistry revealed the patient died from an infection of Ehrlichia chaffeensis. Clinicians and pathologists must be aware of this emergent disease in order to make a timely and appropriate diagnosis. Discussion of the patient's clinical, laboratory and autopsy findings as well as treatment of Ehrlichia chaffeensis infections is presented.
C1 [Pavelites, Joseph J.] Dwight Eisenhower Army Med Ctr, Transit Year Program, GME Off, Ft Gordon, GA 30905 USA.
[Prahlow, Joseph A.] S Bend Med Fdn, South Bend, IN 46601 USA.
[Prahlow, Joseph A.] Univ Notre Dame, Indiana Univ Sch Med S Bend, South Bend, IN 46617 USA.
RP Pavelites, JJ (reprint author), Dwight Eisenhower Army Med Ctr, Transit Year Program, GME Off, Bldg 300,Hosp Rd, Ft Gordon, GA 30905 USA.
EM joseph.pavelites@amedd.army.mil
NR 16
TC 5
Z9 5
U1 0
U2 5
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1547-769X
J9 FORENSIC SCI MED PAT
JI Forensic Sci. Med. Pathol.
PD SEP
PY 2011
VL 7
IS 3
BP 287
EP 293
DI 10.1007/s12024-010-9219-0
PG 7
WC Medicine, Legal; Pathology
SC Legal Medicine; Pathology
GA 799OT
UT WOS:000293296700009
PM 21279705
ER
PT J
AU Killgore, WDS
Kamimori, GH
Balkin, TJ
AF Killgore, William D. S.
Kamimori, Gary H.
Balkin, Thomas J.
TI Caffeine protects against increased risk-taking propensity during severe
sleep deprivation
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE caffeine; impulsiveness; risk-taking; sleep deprivation
ID DECISION-MAKING; TASK BART; PERFORMANCE; MODAFINIL; DEXTROAMPHETAMINE;
OPERATIONS; BRAIN; FMRI
AB Previous research suggests that sleep deprivation is associated with declines in metabolic activity within brain regions important for judgement and impulse control, yet previous studies have reported inconsistent findings regarding the effects of sleep loss and caffeine on risk-taking. In this study, 25 healthy adults (21 men, four women) completed the Balloon Analog Risk Task (BART) and Evaluation of Risks (EVAR) scale at regular intervals to examine behavioral and self-reported risk-taking propensity during 75 h of continuous sleep deprivation. Participants received either four double-blind administrations of 200 mg caffeine (n = 12) or indistinguishable placebo (n = 13) gum bi-hourly during each of the 3 nights of sleep deprivation. No significant effects of drug group or sleep deprivation were evident on the BART or EVAR when measured at 51 h of wakefulness. However, by 75 h, the placebo group showed a significant increase in risk-taking behavior on the cost-benefit ratio and total number of exploded balloons on the BART, whereas the caffeine group remained at baseline levels. On the EVAR, several factors of self-reported risk-taking propensity, including total risk, impulsivity and risk / thrill seeking, were reduced among subjects receiving caffeine across the 3 days of sleep deprivation, but remained at baseline levels for the placebo group. These results suggest that 3 nights of total sleep deprivation led to a significant increase in behavioral risk-taking but not self-reported perception of risk-propensity. Overnight caffeine prevented this increase in risky behavior.
C1 [Killgore, William D. S.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA.
RP Killgore, WDS (reprint author), Harvard Univ, McLean Hosp, Sch Med, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA.
EM killgore@mclean.harvard.edu
OI Killgore, William/0000-0002-5328-0208
FU US Army Medical Research and Materiel Command (USAMRMC)
FX This study was supported by the US Army Medical Research and Materiel
Command (USAMRMC). The views expressed in this paper are those of the
authors and do not reflect the official policy or position of the
Department of the Army, the Department of Defense, the US Government, or
any of the institutions with which the authors are affiliated.
NR 30
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Z9 23
U1 2
U2 26
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0962-1105
J9 J SLEEP RES
JI J. Sleep Res.
PD SEP
PY 2011
VL 20
IS 3
BP 395
EP 403
DI 10.1111/j.1365-2869.2010.00893.x
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 798BO
UT WOS:000293176500004
PM 20946437
ER
PT J
AU Swor, T
Canter, L
AF Swor, Tom
Canter, Larry
TI Promoting environmental sustainability via an expert elicitation process
SO ENVIRONMENTAL IMPACT ASSESSMENT REVIEW
LA English
DT Article
DE Sustainability; Expert elicitation; Mitigation; Cumulative effects
management
AB Environmental sustainability (ES) planning was applied to the 981-mile, commercially navigable Ohio River. Navigation improvement needs were identified within the broad study along with actions to restore aquatic and riparian ecological resources to a higher state of sustainability. The actions were identified via an Expert Elicitation Process (EEP) involving aquatic and riparian/terrestrial experts knowledgeable of Ohio River resources. The received information was synthesized into goals for the selected resources (Valued Ecosystem Components - or VECs), actions or measures to attain the goals, and monitoring to evaluate conditions. Finally, 26 types of ES actions were identified and classified into three ES alternatives. These alternatives were then evaluated relative to key decision criteria, and such evaluations, based on pertinent decision criteria, were also conducted for four navigation improvement alternatives. Finally, the best combination of ES and navigation alternatives was identified. The key lessons derived from this use of EEP were that: (1) EEP can support the preliminary identification of ES measures; however, more detailed study of specific designs and cost evaluations will be necessary: (2) the method promotes collaboration between key scientists and policymakers from governmental agencies and private sectors, and such collaboration will ultimately provide the foundation for implementation of sustainability actions: and (3) an effective EEP does not occur by accident, it requires careful planning, implementation, and documentation. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Swor, Tom] USA, Corps Engineers, Nashville, TN USA.
[Canter, Larry] Environm Impact Training, Horseshoe Bay, TX USA.
[Canter, Larry] Univ Oklahoma, Norman, OK 73019 USA.
RP Swor, T (reprint author), USA, Corps Engineers, Nashville, TN USA.
EM tomswor@ardmore.net
NR 20
TC 8
Z9 8
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0195-9255
J9 ENVIRON IMPACT ASSES
JI Environ. Impact Assess. Rev.
PD SEP
PY 2011
VL 31
IS 5
SI SI
BP 506
EP 514
DI 10.1016/j.eiar.2011.01.014
PG 9
WC Environmental Studies
SC Environmental Sciences & Ecology
GA 791MI
UT WOS:000292668900009
ER
PT J
AU Landrum, ML
Roediger, MP
Fieberg, AM
Weintrob, AC
Okulicz, JF
Crum-Cianflone, NF
Ganesan, A
Lalani, T
Macalino, GE
Chun, HM
AF Landrum, Michael L.
Roediger, Mollie P.
Fieberg, Ann M.
Weintrob, Amy C.
Okulicz, Jason F.
Crum-Cianflone, Nancy F.
Ganesan, Anuradha
Lalani, Tahaniyat
Macalino, Grace E.
Chun, Helen M.
TI Development of Chronic Hepatitis B Virus Infection in Hepatitis B
Surface Antigen Negative HIV/HBV Co-Infected Adults: A Rare
Opportunistic Illness
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE hepatitis B virus; chronic hepatitis B virus; human immunodeficiency
virus; CD4 cell count; opportunistic illness
ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV;
SEROCONVERSION; INDIVIDUALS; EVOLUTION; COHORT; HBV
AB Changes in serologic status in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infected individuals with either isolated anti-HBc or resolved HBV infection have been reported, but the frequency of clinically meaningful long-term serologic changes is not well-defined. This study therefore, examined longitudinal serologic status for hepatitis B surface antigen (HBsAg)-negative HIV/HBV co-infected participants in a large cohort. Among 5,222 cohort participants, 347 (7%) were initially isolated anti-HBc positive, and 1,073 (21%) had resolved HBV infection (concurrently reactive for anti-HBc and anti-HBs). Thirty-three (10%) of the 347 participants with isolated anti-HBc were later positive for HBsAg at least once, compared with 3 (0.3%) of those with resolved HBV (P < 0.001). A total of 14 participants became persistently positive for HBsAg and were thus classified as having late-onset chronic HBV infection at a median of 3.7 years after initial HBV diagnosis. For those initially with HBsAg-negative HIV/HBV co-infection, the rate of late-onset chronic HBV infection was 1.39/1,000 person-years. Those with late-onset chronic HBV infection experienced significant decreases in CD4 cell counts (P = 0.002) with a mean of 132 cells/mu l at the time of late-onset chronic HBV infection, but no factor distinguished those who were positive for HBsAg only once from those that developed late-onset chronic HBV infection. Over a median of 2.9 years following late-onset chronic HBV infection, 3 of 14 subsequently lost HBsAg. The occurrence of late-onset chronic HBV infection in HBsAg negative HIV/HBV co-infected adults appears to be one important, albeit rare, clinical event seen almost exclusively in those with isolated anti-HBc and low CD4 cell count. J. Med. Virol. 83: 1537-1543, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA.
[Landrum, Michael L.; Roediger, Mollie P.; Fieberg, Ann M.; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; Ganesan, Anuradha; Lalani, Tahaniyat; Macalino, Grace E.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Roediger, Mollie P.; Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA.
[Crum-Cianflone, Nancy F.] USN, Med Ctr, Infect Dis Clin, San Diego, CA 92152 USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA.
[Lalani, Tahaniyat] USN, Med Ctr, Div Infect Dis, Portsmouth, VA USA.
[Chun, Helen M.] USN, Hlth Res Ctr, Dept Def HIV AIDS Prevent Program, San Diego, CA 92152 USA.
RP Landrum, ML (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM mlandrum@idcrp.org
FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-27];
Uniformed Services University of the Health Sciences (Department of
Defense (DoD)); National Institute of Allergy and Infectious Diseases;
National Institutes of Health (NIH) [Y1-AI-5072]
FX Grant sponsor: Infectious Disease Clinical Research Program (IDCRP,
www.idcrp.org); Grant number: IDCRP-000-27; Grant sponsor: Uniformed
Services University of the Health Sciences (Department of Defense (DoD)
Program); Grant sponsor: National Institute of Allergy and Infectious
Diseases (in whole or in part); Grant sponsor: National Institutes of
Health (NIH; Inter-Agency Agreement); Grant number: Y1-AI-5072.
NR 16
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD SEP
PY 2011
VL 83
IS 9
BP 1537
EP 1543
DI 10.1002/jmv.22155
PG 7
WC Virology
SC Virology
GA 790OW
UT WOS:000292600100007
PM 21739443
ER
PT J
AU Berkowitz, J
Casper, AF
Noble, C
AF Berkowitz, Jacob
Casper, Andrew F.
Noble, Chris
TI A multiple watershed field test of hydrogeomorphic functional assessment
of headwater streams-Variability in field measurements between
independent teams
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Hydrogeomorphic assessment; HGM; Field testing; Rapid assessment;
Headwater stream
AB Ephemeral and intermittent headwater streams are under increasing pressure from disturbance and development. Rapid, repeatable assessment techniques are needed in order to gauge the condition of these stream systems. Several attributes of these headwater streams constrain the use of the most widely used macroinvertebrate or water quality stream assessment techniques. The hydrogeomorphic (HGM) functional assessment is a reference-based alternative technique. To evaluate this alternative, repeated assessments were conducted in eight high-gradient headwaters in West Virginia by four independent teams. Across-site and measurement variance among teams was assessed using a coefficient of variation (CV, expressed as percent). A variability of >50% CV, which suggests less repeatable results, occurred in only 13.8% of measurements, primarily associated with 2 of the 9 variables examined (snag density and substrate size). Between site measurement variance was the greatest at more highly disturbed sample locations, particularly with regard to the large woody debris, tree species richness, and channel bank erosion variables. Variables with the lowest CV were tree diameter, detrital cover, canopy cover, and channel embeddedness. Based on these results, measurements included when applying HGM approach to these streams should focus on direct measurements or directed estimates that yield a large response range across a spectrum of sites while maintaining consistent repeatability among different teams, with special attention paid to their use in highly disturbed sites. Published by Elsevier Ltd.
C1 [Berkowitz, Jacob; Noble, Chris] USA, Corps Engineers, Wetlands & Coastal Ecol Branch, Environm Lab,Engn Res & Dev Ctr,CEERD EE W, Vicksburg, MS 39180 USA.
[Casper, Andrew F.] USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Berkowitz, J (reprint author), USA, Corps Engineers, Wetlands & Coastal Ecol Branch, Environm Lab,Engn Res & Dev Ctr,CEERD EE W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jacob.F.Berkowitz@usace.army.mil
NR 14
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
J9 ECOL INDIC
JI Ecol. Indic.
PD SEP
PY 2011
VL 11
IS 5
BP 1472
EP 1475
DI 10.1016/j.ecolind.2011.01.004
PG 4
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 774TO
UT WOS:000291409700051
ER
PT J
AU Saraf, R
Lee, HJ
Michielsen, S
Owens, J
Willis, C
Stone, C
Wilusz, E
AF Saraf, Rahul
Lee, Hoon Joo
Michielsen, Stephen
Owens, Jeffery
Willis, Colin
Stone, Corinne
Wilusz, Eugene
TI Comparison of three methods for generating superhydrophobic,
superoleophobic nylon nonwoven surfaces
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID ROUGH SURFACES; WETTABILITY; DESIGN; ENERGY; LOTUS
AB This research deals with creating a superhydrophobic/superoleophobic surface by preparing a metastable Cassie-Baxter (CB) surface. To create a CB surface it is essential to have low surface energy and properly constructed surface morphology. We have explored three different techniques to achieve superhydrophobicity and superoleophobicity using hydroentangled nylon nonwoven fabric: pulsed plasma polymerization of 1H,1H,2H,2H-perfluorodecyl acrylate (PFAC8), microwave-assisted condensation of 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (FS), and FS condensation through wet processing. Nonwoven fabric materials prepared using these three techniques were superhydrophobic and superoleophobic as shown by their very high contact angles for both water (contact angles of 168-174A degrees) and dodecane (contact angles of 153-160A degrees). The measured contact angles agree with the predicted values obtained through designing a CB surface.
C1 [Saraf, Rahul; Lee, Hoon Joo; Michielsen, Stephen] N Carolina State Univ, Raleigh, NC 27695 USA.
[Owens, Jeffery] USAF, Res Lab, Tyndall AFB, FL 32403 USA.
[Willis, Colin; Stone, Corinne] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England.
[Wilusz, Eugene] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Lee, HJ (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA.
EM hoonjoo_lee@ncsu.edu
RI Michielsen, Stephen/C-4726-2015
OI Michielsen, Stephen/0000-0001-8743-1521
FU US Army Natick Soldier Research Development and Engineering Center
(NSRDEC); Air Force Research Laboratory (AFRL) [FA8650-07-1-5903];
Defense Threat Reduction Agency-Joint Science and Technology Office for
Chemical and Biological Defense [HDTRA1-08-1-0049]
FX This material was partially sponsored by US Army Natick Soldier Research
Development and Engineering Center (NSRDEC) and Air Force Research
Laboratory (AFRL) [grant number FA8650-07-1-5903]; and The Defense
Threat Reduction Agency-Joint Science and Technology Office for Chemical
and Biological Defense [grant number HDTRA1-08-1-0049]. The U.S.
Government is authorized to reproduce and distribute reprints for
Governmental purposes notwithstanding any copyright notation thereon. We
thank the Nonwoven Institute (NI) for sharing hydro-entangled nonwoven
fabric with us.
NR 27
TC 24
Z9 25
U1 3
U2 67
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
J9 J MATER SCI
JI J. Mater. Sci.
PD SEP
PY 2011
VL 46
IS 17
BP 5751
EP 5760
DI 10.1007/s10853-011-5530-8
PG 10
WC Materials Science, Multidisciplinary
SC Materials Science
GA 774CU
UT WOS:000291359700020
ER
PT J
AU Ahn, SC
Cha, DK
Kim, BJ
Oh, SY
AF Ahn, Se Chang
Cha, Daniel K.
Kim, Byung J.
Oh, Seok-Young
TI Detoxification of PAX-21 ammunitions wastewater by zero-valent iron for
microbial reduction of perchlorate
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE PAX-21; Perchlorate; Microbial reduction; Zero-valent iron
ID BIODEGRADABILITY; PRETREATMENT; RDX
AB US Army and the Department of Defense (DoD) facilities generate perchlorate (ClO(4)(-)) from munitions manufacturing and demilitarization processes. Ammonium perchlorate is one of the main constituents in Army's new main charge melt-pour energetic, PAX-21. In addition to ammonium perchlorate, hexahydro-1,3,5-trinitro-1.3,5-triazine (RDX) and 2,4-dinitroanisole (DNAN) are the major constituents of PAX-21. In order to evaluate microbial perchlorate reduction as a practical option for the treatment of perchlorate in PAX-21 wastewater, we conducted biodegradation experiments using glucose as the primary sources of electrons and carbon. Batch experiments showed that negligible perchlorate was removed in microbial reactors containing PAX-21 wastewater while control bottles containing seed bacteria and glucose rapidly and completely removed perchlorate. These results suggested that the constituents in PAX-21 wastewater may be toxic to perchlorate reducing bacteria. A series of batch toxicity test was conducted to identify the toxic constituents in PAX-21 and DNAN was identified as the primary toxicant responsible for inhibiting the activity of perchlorate reducing bacteria. It was hypothesized that pretreatment of PAX-21 by zero-valent iron granules will transform toxic constituents in PAX-21 wastewater to non-toxic products. We observed complete reduction of DNAN to 2,4-diaminoanisole (DAAN) and RDX to formaldehyde in abiotic iron reduction study. After a 3-day acclimation period, perchlorate in iron-treated PAX-21 wastewater was rapidly decreased to an undetectable level in 2 days. This result demonstrated that iron treatment not only removed energetic compounds but also eliminated the toxic constituents that inhibited the subsequent microbial process. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Oh, Seok-Young] Univ Ulsan, Dept Civil & Environm Engn, Ulsan 680749, South Korea.
[Ahn, Se Chang; Cha, Daniel K.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Kim, Byung J.] USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA.
RP Oh, SY (reprint author), Univ Ulsan, Dept Civil & Environm Engn, Ulsan 680749, South Korea.
EM quartzoh@ulsan.ac.kr
NR 16
TC 16
Z9 17
U1 3
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD AUG 30
PY 2011
VL 192
IS 2
BP 909
EP 914
DI 10.1016/j.jhazmat.2011.05.104
PG 6
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 799VK
UT WOS:000293314000061
PM 21700387
ER
PT J
AU McElhenny, JE
White, JO
Rogers, SD
Sanamyan, T
Glebov, LB
Mokhun, O
Smirnov, VI
AF McElhenny, John E.
White, Jeffrey O.
Rogers, Steven D.
Sanamyan, Tigran
Glebov, Leonid B.
Mokhun, Oleksiy
Smirnov, Vadim I.
TI Using a volume Bragg grating instead of a Faraday isolator in lasers
incorporating stimulated Brillouin scattering wavefront reversal or beam
cleanup
SO OPTICS EXPRESS
LA English
DT Article
AB A master-oscillator power-amplifier with stimulated Brillouin scattering (SBS) beam cleanup or wavefront reversal typically incorporates a Faraday isolator to outcouple the Stokes light, limiting the power scalability. Volume Bragg gratings (VBGs) have the potential for scaling to higher powers. We report here the results of tests on a VBG designed to resolve wavelengths 0.060 nm apart, corresponding to the 16 GHz frequency shift for SBS backscattering at 1064 nm in fused silica. Such an element may also find use in between stages of fiber amplifiers, for blocking the Stokes wave. (C) 2011 Optical Society of America
C1 [McElhenny, John E.; White, Jeffrey O.; Rogers, Steven D.; Sanamyan, Tigran] USA, Res Lab, Adelphi, MD 20783 USA.
[Glebov, Leonid B.; Mokhun, Oleksiy; Smirnov, Vadim I.] Optigrate, Orlando, FL 32826 USA.
RP McElhenny, JE (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jeffrey.owen.white@arl.army.mil
FU High Energy Laser Joint Technology Office; U.S. Army Research Laboratory
FX Funding for this project was provided by the High Energy Laser Joint
Technology Office. This research was supported in part by an appointment
to the U.S. Army Research Laboratory Postdoctoral Fellowship Program
administered by the Oak Ridge Associated Universities through a contract
with the U.S. Army Research Laboratory. We thank Antonio M. Irujo and
OFS Optics for loaning us the fiber used for SBS.
NR 10
TC 0
Z9 0
U1 0
U2 4
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD AUG 29
PY 2011
VL 19
IS 18
BP 16885
EP 16889
DI 10.1364/OE.19.016885
PG 5
WC Optics
SC Optics
GA 814XE
UT WOS:000294489700016
PM 21935049
ER
PT J
AU Bedrov, D
AF Bedrov, Dmitry
TI Quantum chemistry and reactive ( ReaxFF) molecular dynamics simulations
study of mechanisms of SEI formation in lithium ion batteries
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Bedrov, Dmitry] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
EM d.bedrov@utah.edu
NR 0
TC 0
Z9 0
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 112-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378302042
ER
PT J
AU Beyer, FL
AF Beyer, Frederick L.
TI Polymer self-organization using attractive non-covalent intermolecular
interactions
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 20783 USA.
EM rick.beyer@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 411-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378307109
ER
PT J
AU Bhandari, RK
Logue, B
Hanrahan, D
Oda, R
Rockwood, G
AF Bhandari, Raj K.
Logue, Brian
Hanrahan, Dillon
Oda, Robert
Rockwood, Gary
TI Single run assay for determining cyanide and thiocyanate in biofluids by
chemical ionization GC-MS
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Bhandari, Raj K.; Logue, Brian; Hanrahan, Dillon; Oda, Robert] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA.
[Rockwood, Gary] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
EM raj.bhandari@sdstate.edu
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 204-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300563
ER
PT J
AU Borodin, O
Jow, R
Xing, LD
AF Borodin, Oleg
Jow, Richard
Xing, Lidan
TI Insight into transport properties and oxidative decomposition pathways
of lithium battery electrolytes from MD simulations and DFT
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Borodin, Oleg; Jow, Richard] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
[Xing, Lidan] Univ Utah, Salt Lake City, UT 84112 USA.
EM oleg.borodin@us.army.mil
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 0
TC 1
Z9 1
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 79-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378302338
ER
PT J
AU Carroll, RL
Jo, K
Timperman, A
AF Carroll, R. Lloyd
Jo, Kyoo
Timperman, Aaron
TI Bioanalytical applications of Traveling Wave Electrophoresis
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Carroll, R. Lloyd; Jo, Kyoo] W Virginia Univ, Morgantown, WV 26506 USA.
[Timperman, Aaron] USA, Corps Engineers ERDC CERL, Champaign, IL 61822 USA.
EM lloyd.carroll@mail.wvu.edu
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 214-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300573
ER
PT J
AU Escarsega, JA
Crawford, DM
Orlicki, JA
Rawlett, AM
Lafferman, FL
AF Escarsega, John A.
Crawford, Dawn M.
Orlicki, Joshua A.
Rawlett, Adam M.
Lafferman, Fred L.
TI Environmental considerations for chemical agent resistant coatings
(CARC)
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Escarsega, John A.; Crawford, Dawn M.; Orlicki, Joshua A.; Rawlett, Adam M.; Lafferman, Fred L.] USA, Dept Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM john.a.escarsega@us.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 265-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378306851
ER
PT J
AU Getsinger, K
AF Getsinger, Kurt
TI Use of aquatic herbicides to enhance biological diversity in natural and
managed ecosystems
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Getsinger, Kurt] USA Engineer, Ctr Res & Dev, Vicksburg, MS 39180 USA.
EM Kurt.D.Getsinger@usace.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 34-AGRO
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300383
ER
PT J
AU Hondrogiannis, G
Cullinan, DB
AF Hondrogiannis, George
Cullinan, David B.
TI Analysis of production methods of tetramethylenedisulfotetramine based
on sulfamide-formaldehyde molar ratios
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Hondrogiannis, George; Cullinan, David B.] USA, Forens Analyt Team, Edgewood Chem Biol Ctr, APG, Aberdeen Proving Ground, MD 21010 USA.
EM george.hondrogiannis@us.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 187-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300545
ER
PT J
AU Hsieh, AJ
Strawhecker, KE
AF Hsieh, Alex J.
Strawhecker, Kenneth E.
TI Microstructure analysis of transparent poly(urethane urea) elastomers
via AFM
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Hsieh, Alex J.; Strawhecker, Kenneth E.] USA, RDRL WMM G, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM ahsieh@arl.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 270-PMSE
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378306572
ER
PT J
AU Isayev, O
Crespo-Hernandez, CE
Hill, FC
AF Isayev, Olexandr
Crespo-Hernandez, Carlos E.
Hill, Frances C.
TI Toward real-life petascale applications: Experience at ERDC
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Isayev, Olexandr; Crespo-Hernandez, Carlos E.] Case Western Reserve Univ, Dept Chem, Clevelnd, OH 44106 USA.
[Isayev, Olexandr; Hill, Frances C.] USA, Environm Lab, ERDC, Vicksburg, MS 39218 USA.
EM olexandr@olexandrisayev.com
RI Crespo-Hernandez, Carlos/A-9915-2008
OI Crespo-Hernandez, Carlos/0000-0002-3594-0890
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 210-PHYS
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378305877
ER
PT J
AU Lambeth, RH
Rinderspacher, BC
Strawhecker, KE
Andzelm, JW
Rawlett, AM
AF Lambeth, Robert H.
Rinderspacher, B. Christopher
Strawhecker, Kenneth E.
Andzelm, Jan W.
Rawlett, Adam M.
TI Self-assembly of side-chain metallo-supramolecular polymers: Synthesis
and characterization
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Lambeth, Robert H.; Rinderspacher, B. Christopher; Strawhecker, Kenneth E.; Andzelm, Jan W.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM bob.lambeth@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 372-ORGN
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378305264
ER
PT J
AU Lee, MS
Olson, MA
AF Lee, Michael S.
Olson, Mark A.
TI Adaptive temperature-based replica exchange methods for protein folding
simulations
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Lee, Michael S.; Olson, Mark A.] USA, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM michael.lee@amedd.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 122-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378302051
ER
PT J
AU Mensack, MM
Saamenoi, Y
Boonsong, K
Ewing, R
Cropek, DM
Henry, CS
AF Mensack, Meghan M.
Saamenoi, Yupaporn
Boonsong, Kanokporn
Ewing, Rebecca
Cropek, Donald M.
Henry, Charles S.
TI Microfluidic electrochemical sensing using PDMS cross-linked carbon
paste
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Mensack, Meghan M.; Saamenoi, Yupaporn; Boonsong, Kanokporn; Ewing, Rebecca; Henry, Charles S.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA.
[Cropek, Donald M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
EM meghan.caulum@colostate.edu
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 212-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300571
ER
PT J
AU Nagarajan, S
Bruno, FF
Drew, CP
Nagarajan, R
AF Nagarajan, Subhalakshmi
Bruno, Ferdinando F.
Drew, Christopher P.
Nagarajan, Ramanathan
TI Biocatalytic synthesis of polypyrrole in amphiphilic block copolymer
micelles
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Nagarajan, Subhalakshmi; Bruno, Ferdinando F.; Drew, Christopher P.; Nagarajan, Ramanathan] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
EM Subhalakshmi.Nagarajan.ctr@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 308-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378301726
ER
PT J
AU Nagarajan, S
Drew, CP
Nagarajan, R
AF Nagarajan, Subhalakshmi
Drew, Christopher P.
Nagarajan, Ramanathan
TI Nanoparticle mediated stabilization of immiscible polymer blends
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Nagarajan, Subhalakshmi; Drew, Christopher P.; Nagarajan, Ramanathan] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
EM subhalakshmi.nagarajan.ctr@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 247-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378301662
ER
PT J
AU Nakamura, YK
Dubick, MA
Omaye, ST
AF Nakamura, Yukiko K.
Dubick, Michael A.
Omaye, Stanley T.
TI Effects of co-administration of g-glutamylcysteine (GGC) and conjugated
linoleic acid (CLA) on oxidative stress in human endothelial cells
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Nakamura, Yukiko K.; Omaye, Stanley T.] Univ Nevada, Dept Nutr, Reno, NV 89557 USA.
[Dubick, Michael A.] USA, Inst Surg Res, San Antonio, TX 78234 USA.
EM yukiko@cabnr.unr.edu
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 54-TOXI
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378307520
ER
PT J
AU Orlicki, JA
Williams, AA
Martin, GR
Leighliter, B
Steele, J
Zander, NE
Bujanda, A
AF Orlicki, Joshua A.
Williams, Andre A.
Martin, George R.
Leighliter, Brad
Steele, Joshua
Zander, Nicole E.
Bujanda, Andres
TI Epoxy nanocomposites reinforced with nylon-6,6 nanofibers
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Orlicki, Joshua A.; Williams, Andre A.; Martin, George R.; Leighliter, Brad; Steele, Joshua; Zander, Nicole E.; Bujanda, Andres] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM joshua.orlicki@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 263-PMSE
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378306564
ER
PT J
AU Pasiakos, SM
AF Pasiakos, Stefan M.
TI Reducing the physiological stress of modern warfare: The role of
nutritional science in the US Military
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Pasiakos, Stefan M.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 14-AGFD
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378300102
ER
PT J
AU Rockne, K
Granberg, K
Thai, T
Miller, J
Willoughby, T
AF Rockne, Karl
Granberg, Kelly
Le Thai
Miller, Jennifer
Willoughby, Timothy
TI Receptor modeling of polycyclic aromatic hydrocarbons (PAHs) and
polychlorinated biphenyls (PCBs) in a contaminated harbor airshed
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Rockne, Karl; Granberg, Kelly] Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60546 USA.
[Le Thai; Miller, Jennifer] US Army Corps Engineers, Chicago, IL 60606 USA.
[Willoughby, Timothy] US Geol Survey, Indianapolis, IN 46278 USA.
EM krockne@uic.edu; kgranb3@uic.edu
RI Rockne, Karl/C-1281-2008
OI Rockne, Karl/0000-0002-4976-4955
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 436-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378302722
ER
PT J
AU Samuelson, L
Li, L
Kumar, J
AF Samuelson, Lynne
Li, Lian
Kumar, Jayant
TI Surface science for the soldier
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Samuelson, Lynne] USA, Natick Soldier RDEC, Natick, MA 01760 USA.
[Li, Lian; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01754 USA.
EM lynne.samuelson@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 41-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378301827
ER
PT J
AU Sausa, R
Cabalo, J
AF Sausa, Rosario
Cabalo, Jerry
TI Photoacoustic spectroscopy and modeling of energetic materials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Sausa, Rosario] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Cabalo, Jerry] USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA.
EM sausa@arl.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 429-PHYS
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378306211
ER
PT J
AU Sun, WF
Zhang, BG
Shao, P
Li, YJ
Liu, R
Li, ZJ
Pritchett, TM
Haley, JE
Azenkeng, A
AF Sun, Wenfang
Zhang, Bingguang
Shao, Pin
Li, Yunjing
Liu, Rui
Li, Zhongjing
Pritchett, Timothy M.
Haley, Joy E.
Azenkeng, Alexander
TI Platinum(II) terdentate/diimine complexes as broadband nonlinear
absorbing materials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Sun, Wenfang; Zhang, Bingguang; Shao, Pin; Li, Yunjing; Liu, Rui; Li, Zhongjing] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
[Pritchett, Timothy M.] USA, Res Lab, Adelphi, MD 20783 USA.
[Haley, Joy E.] USAF, Res Lab, Dayton, OH 45433 USA.
[Azenkeng, Alexander] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA.
EM Wenfang.Sun@ndsu.edu
RI shao, pin/D-5790-2011; Liu, Rui/G-3772-2014; li, zhongjing/H-4945-2014
OI li, zhongjing/0000-0002-0125-9693
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 648-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378307359
ER
PT J
AU Tran, DT
Dunbar, ZW
Chu, D
AF Tran, Dat T.
Dunbar, Zachary W.
Chu, Deryn
TI Fuel processing: Adsorbents for liquid phase JP-8 fuel desulfurization
using Au and Ag ions on silica support at ambient conditions
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Tran, Dat T.; Dunbar, Zachary W.; Chu, Deryn] USA, RDRL SED C, Res Lab, Adelphi, MD 20783 USA.
EM dat.tran1@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 56-FUEL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378303382
ER
PT J
AU Wang, K
Camesano, TA
Nagarajan, R
AF Wang, Kathleen
Camesano, Terri A.
Nagarajan, Ramanathan
TI Use of QCM-D overtone data to infer nature of antimicrobial peptide
interactions with model bilayer membrane
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 242nd National Meeting of the American-Chemical-Society (ACS)
CY AUG 28-SEP 01, 2011
CL Denver, CO
SP Amer Chem Soc (ACS)
C1 [Nagarajan, Ramanathan] USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Wang, Kathleen; Camesano, Terri A.] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA.
EM ramanathan.nagarajan@us.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 28
PY 2011
VL 242
MA 277-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 880BE
UT WOS:000299378301692
ER
EF