FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Fan, Y Lou, J Garcia, C Zhai, W Dong, J Wen, W Conrad, F Brown, J Skerry, J Smith, TJ Smith, LA Marks, JD AF Fan, Y. Lou, J. Garcia, C. Zhai, W. Dong, J. Wen, W. Conrad, F. Brown, J. Skerry, J. Smith, T. J. Smith, L. A. Marks, J. D. TI Monoclonal antibodies against botulinum neurotoxin serotype F SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Fan, Y.; Lou, J.; Garcia, C.; Zhai, W.; Dong, J.; Wen, W.; Conrad, F.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco Gen Hosp, San Francisco, CA 94143 USA. [Brown, J.; Skerry, J.; Smith, T. J.] USA, Med Res Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD 21702 USA. [Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA. EM fanf@anesthesia.ucsf.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 85 EP 86 DI 10.1016/j.toxicon.2012.07.079 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500067 ER PT J AU Garcia, C Yan, S Geren, I Lou, J Wen, W Conrad, F Smith, TJ Brown, J Skerry, J Smith, LA Marks, JD AF Garcia, C. Yan, S. Geren, I. Lou, J. Wen, W. Conrad, F. Smith, T. J. Brown, J. Skerry, J. Smith, L. A. Marks, J. D. TI Human monoclonal antibodies binding botulinum neurotoxin types C, D, and mosaic neurotoxins C-D and D-C SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Garcia, C.; Yan, S.; Geren, I.; Lou, J.; Wen, W.; Conrad, F.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA. [Smith, T. J.] USA, Med Res Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD 21702 USA. [Brown, J.; Skerry, J.; Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA. EM garciamc@anesthesia.ucsf.edu NR 0 TC 0 Z9 0 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 86 EP 87 DI 10.1016/j.toxicon.2012.07.082 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500070 ER PT J AU Lyman, ME Tuznik, KM McNutt, P AF Lyman, M. E. Tuznik, K. M. McNutt, P. TI Methods to produce, culture and evaluate embryonic stem-cell-derived neurons as a research tool for botulinum toxin and the black widow spider venom latrotoxin SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Lyman, M. E.; Tuznik, K. M.; McNutt, P.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM megan.lyman1@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 91 EP 91 DI 10.1016/j.toxicon.2012.07.093 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500081 ER PT J AU Shoemaker, CB Mukherjee, J Tremblay, JM Leysath, C Bedenice, D Feng, X Ofori, K Baldwin, K Webb, RP Wright, PM Smith, LA Tzipori, S AF Shoemaker, C. B. Mukherjee, J. Tremblay, J. M. Leysath, C. Bedenice, D. Feng, X. Ofori, K. Baldwin, K. Webb, R. P. Wright, P. M. Smith, L. A. Tzipori, S. TI A Strategy for rapid development and simplified production of therapeutic antitoxins tested on botulinum neurotoxin SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Shoemaker, C. B.; Mukherjee, J.; Tremblay, J. M.; Bedenice, D.; Feng, X.; Ofori, K.; Baldwin, K.; Tzipori, S.] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA USA. [Leysath, C.] NIH, Lab Bacterial Dis, Bethesda, MD 20892 USA. [Webb, R. P.; Wright, P. M.; Smith, L. A.] USA, Med Res Inst Infect Dis, Frederick, MD USA. EM charles.shoemaker@tufts.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 97 EP 97 DI 10.1016/j.toxicon.2012.07.107 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500095 ER PT J AU Sun, Z Lou, J Cheng, L Smith, TJ Dong, J Wen, W Conrad, F Garcia, C Fan, Y Henderson, T Brown, J Skerry, J Smith, LA Harrison, T D'Andrea, A Tomic, M Marks, JD AF Sun, Z. Lou, J. Cheng, L. Smith, T. J. Dong, J. Wen, W. Conrad, F. Garcia, C. Fan, Y. Henderson, T. Brown, J. Skerry, J. Smith, L. A. Harrison, T. D'Andrea, A. Tomic, M. Marks, J. D. TI Comparison of neutralizing abilities of human monoclonal antibodies binding different epitopes on botulinum neurotoxin A SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Sun, Z.; Lou, J.; Dong, J.; Wen, W.; Conrad, F.; Garcia, C.; Fan, Y.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA. [Cheng, L.; Henderson, T.] ARS, Western Reg Res Ctr, USDA, Albany, CA USA. [Brown, J.; Skerry, J.] USA, Med Inst Infect Dis, Integrated Toxinol Div, Ft Detrick, MD USA. [Smith, T. J.; Smith, L. A.] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Harrison, T.; D'Andrea, A.] SRI Int Biosci, Menlo Pk, CA USA. [Tomic, M.] XOMA LLC, Berkeley, CA USA. EM sunz@anesthesia.ucsf.edu NR 0 TC 0 Z9 0 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 98 EP 99 DI 10.1016/j.toxicon.2012.07.110 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500098 ER PT J AU Tomic, M Garcia, C Lou, J Geren, IN Meng, Q Conrad, F Wen, W Smith, TJ Brown, J Smith, LA Wajid, A Dadson, AC Horwitz, AH Freeberg, J Marks, JD AF Tomic, M. Garcia, C. Lou, J. Geren, I. N. Meng, Q. Conrad, F. Wen, W. Smith, T. J. Brown, J. Smith, L. A. Wajid, A. Dadson, A. C., Jr. Horwitz, A. H. Freeberg, J. Marks, J. D. TI Recombinant monoclonal-antibody-based antitoxins for treatment of types A, B, and E botulism SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Tomic, M.; Wajid, A.; Dadson, A. C., Jr.; Horwitz, A. H.; Freeberg, J.] XOMA LLC, Berkeley, CA USA. [Smith, T. J.; Brown, J.; Smith, L. A.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Garcia, C.; Lou, J.; Geren, I. N.; Meng, Q.; Conrad, F.; Wen, W.; Marks, J. D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco Gen Hosp, San Francisco, CA 94143 USA. EM tomic@xoma.com NR 0 TC 0 Z9 0 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 99 EP 100 DI 10.1016/j.toxicon.2012.07.113 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500101 ER PT J AU Tuznik, KM Lyman, ME McNutt, PM AF Tuznik, K. M. Lyman, M. E. McNutt, P. M. TI Design and enzymatic response of engineered botulinum neurotoxin B-insensitive VAMP-2 mutants SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Tuznik, K. M.; Lyman, M. E.; McNutt, P. M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM kaylie.tuznik@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 101 EP 101 DI 10.1016/j.toxicon.2012.07.116 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500104 ER PT J AU Zuniga, J Hammill, J Drory, O Nuss, J Burnett, J Gussio, R Wipf, P Bavari, S Brunger, AT AF Zuniga, J. Hammill, J. Drory, O. Nuss, J. Burnett, J. Gussio, R. Wipf, P. Bavari, S. Brunger, A. T. TI Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Zuniga, J.; Drory, O.; Brunger, A. T.] Howard Hughes Med Inst, Stanford, CA USA. [Zuniga, J.; Drory, O.; Brunger, A. T.] Stanford Univ, Stanford, CA 94305 USA. [Hammill, J.; Wipf, P.] Univ Pittsburgh, Pittsburgh, PA USA. [Nuss, J.; Bavari, S.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Burnett, J.] NCI, Frederick, MD 21701 USA. [Gussio, R.] NCI, Dev Therapeut Program, Frederick, MD 21701 USA. EM jzuniga@stanford.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 103 EP 104 DI 10.1016/j.toxicon.2012.07.122 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500110 ER PT J AU Alvarez, MV Grogan, PM AF Alvarez, M. V. Grogan, P. M. TI Is there a role for rimabotulinumtoxinB In the treatment of medication-resistant low back pain? SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Alvarez, M. V.] Ctr Neurol Care & Res, San Antonio, TX USA. [Grogan, P. M.] Brooke Army Med Ctr, Dept Neurol, Ft Sam Houston, TX 78234 USA. EM vikki.alvarez@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 104 EP 105 DI 10.1016/j.toxicon.2012.07.125 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500113 ER PT J AU Bland, CM Tritsch, AM Bookstaver, DA Sweeney, LB Wiley, D Choi, YU AF Bland, Christopher M. Tritsch, Adam M. Bookstaver, David A. Sweeney, Lori B. Wiley, Dan Choi, Yong U. TI Hypertension and diabetes mellitus medication management in sleeve gastrectomy patients SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material ID BARIATRIC SURGERY; OBESITY C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Bland, Christopher M.; Wiley, Dan] Univ Georgia, Coll Pharm, Athens, GA 30602 USA. RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Hosp Rd Bldg 300, Ft Gordon, GA 30905 USA. EM chris.bland@us.army.mil NR 13 TC 2 Z9 3 U1 0 U2 5 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD JUN 15 PY 2013 VL 70 IS 12 BP 1018 EP 1020 DI 10.2146/ajhp120607 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 161SU UT WOS:000320214400009 PM 23719877 ER PT J AU Herrell, R Bliese, P Hoge, C AF Herrell, Richard Bliese, Paul Hoge, Charles TI PTSD, DEPRESSION, AND SUICIDALITY IN A SAMPLE OF US SOLDIERS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 [Herrell, Richard; Bliese, Paul; Hoge, Charles] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 2013 VL 177 SU 11 BP S28 EP S28 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 157BL UT WOS:000319870300109 ER PT J AU Muench, SP Stec, J Zhou, Y Afanador, GA McPhillie, MJ Hickman, MR Lee, PJ Leed, SE Auschwitz, JM Prigge, ST Rice, DW McLeod, R AF Muench, Stephen P. Stec, Jozef Zhou, Ying Afanador, Gustavo A. McPhillie, Martin J. Hickman, Mark R. Lee, Patty J. Leed, Susan E. Auschwitz, Jennifer M. Prigge, Sean T. Rice, David W. McLeod, Rima TI Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Enoyl reductase; Triclosan; Toxoplasma; Plasmodium ID CARRIER PROTEIN REDUCTASE; ENOYL-ACP REDUCTASE; FATTY-ACID BIOSYNTHESIS; PLASMODIUM-FALCIPARUM; TOXOPLASMA-GONDII; ESCHERICHIA-COLI; INHIBITION; TARGET; PARASITES; DELIVERY AB The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of tri-closan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Muench, Stephen P.] Univ Leeds, Sch Biomed Sci, Leeds, W Yorkshire, England. [Stec, Jozef] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA. [Zhou, Ying; McLeod, Rima] Univ Chicago, Inst Genom & Syst Biol & Coll, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. [Afanador, Gustavo A.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA. [McPhillie, Martin J.; Rice, David W.] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England. [Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Discovery, Silver Spring, MD 20910 USA. RP Muench, SP (reprint author), Univ Leeds, Sch Biomed Sci, Leeds, W Yorkshire, England. EM s.p.muench@leeds.ac.uk; jstec@csu.edu OI Muench, Stephen/0000-0001-6869-4414 FU NIAID [U01 AI082180-01]; Rooney-Alden family; Taub family; Engel family; Pritzker family; Harris family; Kapnick family; Mussilami family; Samuel family; Mann-Cornwell Family Foundation; MRC Career Development fellowship [G1000567] FX We thank Dr. Alan Kozikowski for his contributions. The authors are grateful for the financial support provided by NIAID U01 AI082180-01 and the Rooney-Alden, Taub, Engel, Pritzker, Harris, Kapnick, Mussilami and Samuel families and the Mann-Cornwell Family Foundation. SPM is supported by an MRC Career Development fellowship (G1000567). NR 37 TC 7 Z9 7 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD JUN 15 PY 2013 VL 23 IS 12 BP 3551 EP 3555 DI 10.1016/j.bmcl.2013.04.035 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 148ST UT WOS:000319268500015 PM 23664871 ER PT J AU Mackie, DM Liu, SC Benyamin, M Ganguli, R Sumner, JJ AF Mackie, David M. Liu, Sanchao Benyamin, Marcus Ganguli, Rahul Sumner, James J. TI Direct utilization of fermentation products in an alcohol fuel cell SO JOURNAL OF POWER SOURCES LA English DT Article DE Proton exchange membrane fuel cell; Microbial; Ethanol; Yeast; Fermentation; Glucose ID POWER-GENERATION; HYDROGEN; ETHANOL; ELECTROOXIDATION; TEMPERATURE; PERFORMANCE; OXIDATION; CATALYSTS AB Due to energy demands and environmental concerns there has been a great interest in searching out renewable energy sources as an alternative to fossil hydrocarbons. These must also be environmentally sustainable and convenient to implement. Glucose has been proposed as a renewable energy source for several reasons including its energy density, safety, sustainability, and the ability to be scavenged from native ecosystems or from waste streams. Here we describe the use of a bio-hybrid fuel cell to oxidize the glucose to ethanol and limit parasitic power losses by using the fermented alcohol with minimal preparation in a direct alcohol fuel cell. Moving from using dilute alcohol in deionized water to the complex matrices of fermented media raises many questions about the performance and lifetime of the fuel cell and its components. These questions include but are not limited to the effects of starting materials and byproducts of the fermentations and the performance of the catalytic oxidation of ethanol at metal catalysts in batch mode. This study examines the effects of multiple components such as ionic strength, cation size, buffering strength, alcohol concentration, fermentation/fuel cell byproducts, and interfering organics on fuel cell operation. Published by Elsevier B.V. C1 [Mackie, David M.; Liu, Sanchao; Benyamin, Marcus; Sumner, James J.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Ganguli, Rahul] Teledyne Sci & Imaging LLC, Thousand Oaks, CA 91360 USA. RP Sumner, JJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM david.m.mackie.civ@mail.mil; sanchao.liu.ctr@mail.mil; marcus.s.benyamin.ctr@mail.mil; rganguli@teledyne-si.com; james.j.sumner4.civ@mail.mil FU U.S. Army's Institute of Collaborative Biotechnologies (ICB) [W911NF-09-D-0001]; US Army Research Laboratory, Sensors and Electron Devices Directorate (ARL-SEDD); Science and Engineering Apprenticeship Program (SEAP) FX The authors acknowledge funding from the U.S. Army's Institute of Collaborative Biotechnologies (ICB) under contract number W911NF-09-D-0001. The authors also acknowledge K. Chu for laboratory support and D. Chu for helpful conversations as well as the support of the US Army Research Laboratory, Sensors and Electron Devices Directorate (ARL-SEDD). M.B. acknowledges the Science and Engineering Apprenticeship Program (SEAP) for support. S.L. acknowledges General Technical Services (GTS) for administrative support. NR 20 TC 4 Z9 4 U1 2 U2 65 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUN 15 PY 2013 VL 232 BP 34 EP 41 DI 10.1016/j.jpowsour.2013.01.077 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 141UU UT WOS:000318752800007 ER PT J AU Orlicki, JA Zander, NE Martin, GR Kosik, WE Demaree, JD Leadore, JL Rawlett, AM AF Orlicki, Joshua A. Zander, Nicole E. Martin, George R. Kosik, Wendy E. Demaree, J. Derek Leadore, Julia L. Rawlett, Adam M. TI Self-segregating hyperbranched polymer/silver nanoparticle hybrids in thermoplastic polyurethane films SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE nanoparticles; nanowires; nanocrystals; films; dendrimers; hyperbranched polymers; macrocycles; surfaces; interfaces ID SILVER NANOPARTICLES; POLY(METHYL METHACRYLATE); ALIPHATIC POLYESTERS; SURFACE SEGREGATION; BLOCK-COPOLYMERS; GOLD; DISPERSION; ADDITIVES; COATINGS; MATRICES AB Self-segregating hyperbranched polymer (HBP) additives have been utilized to concentrate silver nanoparticles (AgNPs) at the air interface of polyurethane films. The limited spontaneous surface migration of the AgNPs was enhanced through the addition of appropriately functionalized HBPs. Both amine and thiol terminated additives were employed to allow interaction of the HBP with the nanoparticles. Both types of additives increased surface concentration of silver modestly, though the thiol-terminated HBPs demonstrated nearly a seven-fold enhancement of surface migration. It was also found that wholly-aliphatic HBPs demonstrated only slightly reduced ability to bias AgNP concentration as compared to HBPs functionalized with perfluorinated chains. In addition, films containing 1% total silver concentration were tested for antimicrobial activity using the ASTM-E 2180 protocol. Significant reduction of the microorganisms was observed for all samples, 6-log reduction was achieved for the gram-negative bacteria P. aeruginosa, the gram-positive bacteria S. aureus, and the fungi C. albicans. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 C1 [Orlicki, Joshua A.; Zander, Nicole E.; Martin, George R.; Kosik, Wendy E.; Demaree, J. Derek; Leadore, Julia L.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Orlicki, JA (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM joshua.a.orlicki.civ@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory; Director's Research Initiative FX This research was supported in part through an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. It was also conducted with the support from the Director's Research Initiative. The authors would like to thank BASF and Perstorp for their generous donation of materials. NR 52 TC 3 Z9 3 U1 4 U2 139 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JUN 15 PY 2013 VL 128 IS 6 BP 4181 EP 4188 DI 10.1002/app.38620 PG 8 WC Polymer Science SC Polymer Science GA 113UY UT WOS:000316696000081 ER PT J AU Sanchez, CJ Ward, CL Romano, DR Hurtgen, BJ Hardy, SK Woodbury, RL Trevino, AV Rathbone, CR Wenke, JC AF Sanchez, Carlos J., Jr. Ward, Catherine L. Romano, Desiree R. Hurtgen, Brady J. Hardy, Sharanda K. Woodbury, Ronald L. Trevino, Alex V. Rathbone, Christopher R. Wenke, Joseph C. TI Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Biofilm; Osteoblast; Osteogenic differentiation; Staphylococcus aureus; Receptor activator of NF-kB ligand; Osteoprotegrin ID NECROSIS-FACTOR RECEPTOR; BACTERIAL BIOFILMS; OSTEOCLAST DIFFERENTIATION; HUMAN KERATINOCYTES; HUMAN NEUTROPHILS; HUMAN FIBROBLASTS; PLASMA-MEMBRANE; CHRONIC WOUNDS; STAPHOPAIN B; HOST-DEFENSE AB Background: Osteomyelitis is a severe and often debilitating disease characterized by inflammatory destruction of bone. Despite treatment, chronic infection often develops which is associated with increased rates of treatment failure, delayed osseous-union, and extremity amputation. Within affected bone, bacteria exist as biofilms, however the impact of biofilms on osteoblasts during disease are unknown. Herein, we evaluated the effect of S. aureus biofilms on osteoblast viability, osteogenic potential, and the expression of the pro-osteoclast factor, receptor activator of NF-kB ligand (RANK-L). Methods: Osteoblasts were exposed to biofilm conditioned media (BCM) from clinical wound isolates of Staphylococcus aureus under normal growth and osteogenic conditions to assess cellular viability and osteoblast differentiation, respectively. Cell viability was evaluated using a live/dead assay and by quantifying total cellular DNA at days 0, 1, 3, 5, and 7. Apoptosis following treatment with BCM was measured by flow-cytometry using the annexin V-FITC/PI apoptosis kit. Osteogenic differentiation was assessed by measuring alkaline phosphatase activity and intracellular accumulation of calcium and osteocalcin for up to 21 days following exposure to BCM. Expression of genes involved in osteogenic differentiation and osteoclast regulation, were also evaluated by quantitative real-time PCR. Results: BCM from clinical strains of S. aureus reduced osteoblast viability which was accompanied by an increase in apoptosis. Osteogenic differentiation was significantly inhibited following treatment with BCM as indicated by decreased alkaline phosphatase activity, decreased intracellular accumulation of calcium and inorganic phosphate, as well as reduced expression of transcription factors and genes involved in bone mineralization in viable cells. Importantly, exposure of osteoblasts to BCM resulted in up-regulated expression of RANK-L and increase in the RANK-L/OPG ratio compared to the untreated controls. Conclusions: Together these studies suggest that soluble factors produced by S. aureus biofilms may contribute to bone loss during chronic osteomyelitis simultaneously by: (1) reducing osteoblast viability and osteogenic potential thereby limiting new bone growth and (2) promoting bone resorption through increased expression of RANK-L by osteoblasts. To our knowledge these are the first studies to demonstrate the impact of staphylococcal biofilms on osteoblast function, and provide an enhanced understanding of the pathogenic role of staphylococcal biofilms during osteomyelitis. C1 [Sanchez, Carlos J., Jr.; Ward, Catherine L.; Romano, Desiree R.; Hurtgen, Brady J.; Hardy, Sharanda K.; Woodbury, Ronald L.; Trevino, Alex V.; Rathbone, Christopher R.; Wenke, Joseph C.] USA, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA. RP Sanchez, CJ (reprint author), USA, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA. EM carlos.j.sanchez3@us.army.mil FU Combat Casualty Research Program, Medical Research and Materiel Command; Post-doctoral Research Associate Fellowship through the National Academy of Sciences FX This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Materiel Command to JCW. CJS, CLW and BJH are supported by a Post-doctoral Research Associate Fellowship through the National Academy of Sciences. NR 54 TC 13 Z9 14 U1 0 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD JUN 14 PY 2013 VL 14 AR 187 DI 10.1186/1471-2474-14-187 PG 11 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 171HN UT WOS:000320916000001 PM 23767824 ER PT J AU Smith, TJ Rigassio-Radler, D Denmark, R Haley, T Touger-Decker, R AF Smith, Tracey J. Rigassio-Radler, Diane Denmark, Robert Haley, Timothy Touger-Decker, Riva TI Effect of Lactobacillus rhamnosus LGG (R) and Bifidobacterium animalis ssp lactis BB-12 (R) on health-related quality of life in college students affected by upper respiratory infections SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Probiotics; Respiratory tract infections; Common cold; Lactobacillus; Bifidobacterium ID SEVERE ACUTE-PANCREATITIS; DOUBLE-BLIND; COMMON COLD; PROBIOTIC PROPHYLAXIS; UNIVERSITY-STUDENTS; CONTROLLED-TRIAL; IMMUNE-SYSTEM; ACID BACTERIA; MODULATION; EXERCISE AB College students are susceptible to upper respiratory infections (URI) due to inadequate sleep, stress and close living quarters. Certain probiotic strains modulate immune function and may improve health-related quality of life (HRQL) during URI. The present study recruited apparently healthy college students and assessed the effect of probiotics on HRQL outcomes (i.e. self-reported duration, symptom severity and functional impairment of URI) in those who developed URI. Missed school and work days due to URI were also considered. Subjects (n 231) were apparently healthy college students living on campus in residence halls at the Framingham State University (Framingham, MA, USA), and were randomised to receive placebo (n 117) or probiotic-containing powder (daily dose of minimum 1 billion colony-forming units of each Lactobacillus rhamnosus LGG (R) (LGG (R)) and Bifidobacterium animalis ssp. lactis BB-12 (R) (BB-12 (R)); n 114) for 12 weeks. Subjects completed The Wisconsin Upper Respiratory Symptom Survey-21 to assess HRQL during URI. The final analyses included 198 subjects (placebo, n 97 and probiotics, n 101). The median duration of URI was significantly shorter by 2 d and median severity score was significantly lower by 34% with probiotics v. placebo (P<0.001), indicating a higher HRQL during URI. Number of missed work days was not different between groups (P=0.429); however, the probiotics group missed significantly fewer school days (mean difference = 0.2 d) compared to the placebo group (P=0.002). LGG (R) and BB-12 (R) may be beneficial among college students with URI for mitigating decrements in HRQL. More research is warranted regarding mechanisms of action associated with these findings and the cost-benefit of prophylactic supplementation. C1 [Smith, Tracey J.; Rigassio-Radler, Diane; Touger-Decker, Riva] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Nutr Sci, Newark, NJ 07101 USA. [Denmark, Robert] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Interdisciplinary Studies, Newark, NJ 07101 USA. [Haley, Timothy] Univ Med & Dent New Jersey, Sch Hlth Related Profess, Adjunct Fac, Newark, NJ 07101 USA. [Haley, Timothy] USA, Off Med Support & Oversight, Environm Med Res Inst, Natick, MA 01760 USA. RP Smith, TJ (reprint author), Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Nutr Sci, 65 Bergen St,Room 157, Newark, NJ 07101 USA. EM smitht9@umdnj.edu FU Chr Hansen A/S (Hoersholm, Denmark) FX The present study was funded by Chr Hansen A/S (Hoersholm, Denmark). Chr Hansen A/S provided the probiotics and placebo products, and provided input towards the study design and final report. However, the company had no involvement in data collection, analysis or interpretation. The authors declare no conflicts of interest. T. J. S. designed the study, coordinated data acquisition, performed the statistical analysis and drafted the manuscript. D. R.-R., R. T.-D., R. D. and T. H. made substantial contributions to study design and critically revised the manuscript for intellectual content. The authors wish to thank study subjects and research assistants from the Framingham State University, Framingham, MA (USA). NR 50 TC 12 Z9 13 U1 3 U2 23 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 J9 BRIT J NUTR JI Br. J. Nutr. PD JUN 14 PY 2013 VL 109 IS 11 BP 1999 EP 2007 DI 10.1017/S0007114512004138 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 146WT UT WOS:000319126700009 PM 23020819 ER PT J AU Lu, XCM Dave, JR Chen, ZY Cao, Y Liao, ZL Tortella, FC AF Lu, Xi-Chun May Dave, Jitendra R. Chen, Zhiyong Cao, Ying Liao, Zhilin Tortella, Frank C. TI Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate SO LIFE SCIENCES LA English DT Article DE Brain ischemia; Nonconvulsive seizures; Nefiracetam; EEG; Veratridine; Glutamate; Rat ID CONVULSIVE STATUS EPILEPTICUS; NICOTINIC ACETYLCHOLINE-RECEPTORS; SUSTAINED CEREBRAL-ISCHEMIA; NATIONWIDE INPATIENT SAMPLE; NOOTROPIC AGENT NEFIRACETAM; TRAUMATIC BRAIN-INJURY; ANTIEPILEPTIC DRUGS; SUBARACHNOID HEMORRHAGE; CORTICAL-NEURONS; ANTICONVULSANT AB Aims: Stroke patients are at a high risk of developing post-ischemic seizures and cognitive impairment. Nefiracetam (NEF), a pyrrolidone derivative, has been shown to possess both anti-epileptic and cognitive-enhancing properties. In this study the anti-seizure effects of NEF were evaluated in a rat model of post-ischemic nonconvulsive seizures (NCSs). Its potential mechanisms were investigated in neuronal cell culture assays of neurotoxicity associated with ischemic brain injury and epileptogenesis. Main methods: In the in vivo study, rats received 24 h permanent middle cerebral artery occlusion. NEF was administered intravenously either at 15 min post-injury but prior to the first NCS event (30 mg/kg, pre-NCS treatment) or immediately after the first NCS occurred (30 or 60 mg/kg, post-NCS treatment). In the in vitro study, neuronal cell cultures were exposed to veratridine or glutamate and treated with NEF (1-500 nM). Key findings: The NEF pre-NCS treatment significantly reduced the NCS frequency and duration, whereas the higher NEF dose (60 mg/kg) was required to achieve similar effects when given after NCS occurred. The NEF treatment also dose-dependently (5-500 nM) protected against neuronal cell death induced by veratridine as measured by MTT cell viability assay, but higher doses (250-500 nM) were required against glutamate toxicity. Significance: The anti-seizure property of NEF was demonstrated in a clinically relevant rat model of post-ischemic NCS. The preferential effects of NEF against in vitro veratridine toxicity suggest the involvement of its modulation of sodium channel malfunction. Future studies are warranted to study the mechanisms of NEF against ischemic brain injury and post-ischemic seizures. Published by Elsevier Inc. C1 [Lu, Xi-Chun May; Dave, Jitendra R.; Chen, Zhiyong; Cao, Ying; Liao, Zhilin; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma & Neuroprotect & Neurorestora, Silver Spring, MD 20910 USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma & Neuroprotect & Neurorestora, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM may.lu@us.army.mil NR 35 TC 3 Z9 3 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD JUN 13 PY 2013 VL 92 IS 22 BP 1055 EP 1063 DI 10.1016/j.lfs.2013.04.004 PG 9 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 160AJ UT WOS:000320088100003 PM 23603142 ER PT J AU Rodriguez-Santiago, V Vargas-Gonzalez, L Bujanda, AA Baeza, JA Fleischman, MS Yim, JH Pappas, DD AF Rodriguez-Santiago, Victor Vargas-Gonzalez, Lionel Bujanda, Andres A. Baeza, Jose A. Fleischman, Michelle S. Yim, Jacqueline H. Pappas, Daphne D. TI Modification of Silicon Carbide Surfaces by Atmospheric Pressure Plasma for Composite Applications SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE silicon carbide; dielectric barrier discharges; bonding; surface modification; grit blasting ID OXYGEN PLASMA; DISCHARGE; CERAMICS; ADHESION; POLYMERS; ALUMINA; ARMOR; EPOXY AB In this study, we explore the use of atmospheric pressure plasmas for enhancing the adhesion of SiC surfaces using a urethane adhesive, as an alternative to grit blasting Surface analysis showed that He-O-2 plasma treatments resulted in a hydrophilic Surface mostly by producing SiOx. Four point bending tests and bonding pull tests were carried out on control, grit-blasted, and plasma-treated surfaces. Grit-blasted samples showed enhanced bonding but also a decrease in flexural strength. Plasma treated samples did not affect the flexural strength of the material and showed an increase in bonding strength. These results suggest that atmospheric pressure plasma treatment of ceramic materials, is an effective alternative to grit blasting for adhesion enhancement. C1 [Rodriguez-Santiago, Victor; Vargas-Gonzalez, Lionel; Bujanda, Andres A.; Baeza, Jose A.; Fleischman, Michelle S.; Yim, Jacqueline H.; Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rodriguez-Santiago, V (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM victor.rodriguez31@us.army.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686; Rodriguez-Santiago, Victor/0000-0002-8389-5414; Vargas-Gonzalez, Laura/0000-0003-1173-3704 NR 26 TC 4 Z9 4 U1 2 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JUN 12 PY 2013 VL 5 IS 11 BP 4725 EP 4730 DI 10.1021/am303227q PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 165KY UT WOS:000320484000034 PM 23639326 ER PT J AU Cywes-Bentley, C Skurnik, D Zaidi, T Roux, D DeOliveira, RB Garrett, WS Lu, X O'Malley, J Kinzel, K Zaidi, T Rey, A Perrin, C Fichorova, RN Kayatani, AKK Maira-Litran, T Gening, ML Tsvetkov, YE Nifantiev, NE Bakaletz, LO Pelton, SI Golenbock, DT Pier, GB AF Cywes-Bentley, Colette Skurnik, David Zaidi, Tanweer Roux, Damien DeOliveira, Rosane B. Garrett, Wendy S. Lu, Xi O'Malley, Jennifer Kinzel, Kathryn Zaidi, Tauqeer Rey, Astrid Perrin, Christophe Fichorova, Raina N. Kayatani, Alexander K. K. Maira-Litran, Tomas Gening, Marina L. Tsvetkov, Yury E. Nifantiev, Nikolay E. Bakaletz, Lauren O. Pelton, Stephen I. Golenbock, Douglas T. Pier, Gerald B. TI Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE immunotherapy; infectious diseases; malaria; carbohydrates; animal models ID POLY-N-ACETYLGLUCOSAMINE; HUMAN MONOCLONAL-ANTIBODIES; STAPHYLOCOCCUS-AUREUS; SURFACE POLYSACCHARIDE; CONJUGATE VACCINES; UNITED-STATES; DISPERSIN-B; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; STREPTOCOCCUS-PNEUMONIAE; NEISSERIA-MENINGITIDIS AB Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A beta-(1 -> 6)-linked poly-N-acetyl-D-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative bacterial pathogens. We report that many microbial pathogens lacking an identifiable intercellular adhesion or polyglucosamine locus produce PNAG, including Gram-positive, Gram-negative, and fungal pathogens, as well as protozoa, e. g., Trichomonas vaginalis, Plasmodium berghei, and sporozoites and blood-stage forms of Plasmodium falciparum. Natural antibody to PNAG is common in humans and animals and binds primarily to the highly acetylated glycoform of PNAG but is not protective against infection due to lack of deposition of complement opsonins. Polyclonal animal antibody raised to deacetylated glycoforms of PNAG and a fully human IgG1 monoclonal antibody that both bind to native and deacetylated glycoforms of PNAG mediated complement-dependent opsonic or bactericidal killing and protected mice against local and/or systemic infections by Streptococcus pyogenes, Streptococcus pneumoniae, Listeria monocytogenes, Neisseria meningitidis serogroup B, Candida albicans, and P. berghei ANKA, and against colonic pathology in a model of infectious colitis. PNAG is also a capsular polysaccharide for Neisseria gonorrhoeae and nontypable Hemophilus influenzae, and protects cells from environmental stress. Vaccination targeting PNAG could contribute to immunity against serious and diverse prokaryotic and eukaryotic pathogens, and the conserved production of PNAG suggests that it is a critical factor in microbial biology. C1 [Cywes-Bentley, Colette; Skurnik, David; Zaidi, Tanweer; Roux, Damien; Lu, Xi; O'Malley, Jennifer; Kinzel, Kathryn; Zaidi, Tauqeer; Maira-Litran, Tomas; Pier, Gerald B.] Harvard Univ, Sch Med, Dept Med, Div Infect Dis,Brigham & Womens Hosp, Boston, MA 02115 USA. [DeOliveira, Rosane B.; Golenbock, Douglas T.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA. [Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Immunol & Infect Dis, Boston, MA 02115 USA. [Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Genet, Boston, MA 02115 USA. [Garrett, Wendy S.] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Complex Dis, Boston, MA 02115 USA. [Rey, Astrid; Perrin, Christophe] Sanofi Res & Dev, Therapeut Strateg Unit, Infect Dis, F-31270 Toulouse, France. [Fichorova, Raina N.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Genital Tract Biol,Dept Obstet Gynecol & Repr, Boston, MA 02115 USA. [Kayatani, Alexander K. K.] Walter Reed Army Inst Res, Mil Malaria Res Program, Vaccine Branch, Silver Spring, MD 20910 USA. [Gening, Marina L.; Tsvetkov, Yury E.; Nifantiev, Nikolay E.] ND Zelinskii Inst Organ Chem, Lab Glycoconjugate Chem, Moscow 119991, Russia. [Bakaletz, Lauren O.] Nationwide Childrens Hosp, Res Inst, Columbus, OH 43205 USA. [Bakaletz, Lauren O.] Ohio State Univ, Coll Med, Columbus, OH 43205 USA. [Pelton, Stephen I.] Boston Univ, Med Ctr, Dept Pediat Infect Dis, Boston, MA 02118 USA. RP Pier, GB (reprint author), Harvard Univ, Sch Med, Dept Med, Div Infect Dis,Brigham & Womens Hosp, Boston, MA 02115 USA. EM gpier@rics.bwh.harvard.edu RI Roux, Damien/C-5618-2014; Fichorova, Raina/G-9969-2014; Roux, Damien/L-3671-2014; OI Roux, Damien/0000-0002-6103-6416; Roux, Damien/0000-0002-6103-6416; Pier, Gerald/0000-0002-9112-2331; Pelton, Stephen/0000-0003-4862-5344 FU NIAID [AI46706, AI057159, U54 AI057159, 5R01AI079085-04, RO1AI079293] FX We gratefully acknowledge the following individuals for supplying microbial strains or tissue samples: Dr. Peter Rice (University of Massachusetts Medical School); Dr. Lee Wetzler (Boston University Medical School); Drs. Daniel Milner, Eric Rubin, and Marc Lipsitch (Harvard School of Public Health), Drs. Richard Malley and Michael Wessels (Children's Hospital, Harvard Medical School); Dr. Darren Higgins (Harvard Medical School); Drs. Laurie Comstock, Maria Chatzidaki-Livanis, Neeraj (Neil) Surana, and Lynn Bry (Brigham and Women's Hospital, Harvard Medical School); Dr. Yung-Fu Chang (Cornell College of Veterinary Medicine); Dr. Joanna Goldberg (University of Virginia Medical School); Drs. Stanley Spinola and Margaret Bauer (Indiana University Medical School); Dr. Darlene Miller (Bascom-Palmer Eye Institute, University of Miami); Dr. Arturo Casadevall (Albert Einstein College of Medicine); Dr. Janet Yother (University of Alabama, Birmingham); Dr. Sandra Richter (University of Iowa); Dr. Janet Lindow (University of Vermont); Dr. Alan Cross (University of Maryland School of Medicine); Dr. Kwang Sik Kim (The Johns Hopkins University School of Medicine); Dr. Rachel McLoughlin (University College Dublin); and Dr. Johannes Huebner (Ludwig Maximilians University). We also gratefully acknowledge the technical expertise and help of Ms. Maria Ericsson with electron microscopy and Ms. Ariana Huebner with laboratory experiments. This work was supported by NIAID Grants AI46706 and AI057159, a component of Award U54 AI057159. The work with T. vaginalis was supported by NIAID Grant 5R01AI079085-04 and the work with P. berghei was supported by NIAID Grant RO1AI079293. NR 58 TC 41 Z9 42 U1 0 U2 21 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 11 PY 2013 VL 110 IS 24 BP E2209 EP E2218 DI 10.1073/pnas.1303573110 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 171LM UT WOS:000320930100011 PM 23716675 ER PT J AU Grande, M Stomeo, T Bianco, GV Vincenti, MA de Ceglia, D Petruzzelli, V Bruno, G De Vittorio, M Scalora, M D'Orazio, A AF Grande, M. Stomeo, T. Bianco, G. V. Vincenti, M. A. de Ceglia, D. Petruzzelli, V. Bruno, G. De Vittorio, M. Scalora, M. D'Orazio, A. TI Fabrication of doubly resonant plasmonic nanopatch arrays on graphene SO APPLIED PHYSICS LETTERS LA English DT Article ID RAMAN-SCATTERING; METAMATERIALS; ENHANCEMENT; SUBSTRATE; PLATFORM; OPTICS AB We report theoretical and experimental investigations of the optical response of two-dimensional periodic arrays of rectangular gold nanopatches grown on a monolayer graphene placed on a glass substrate. We discuss the numerical analysis and optical characterization by means of reflection spectra and show that rectangular nanopatches display a polarization-dependent response, at normal incidence, which leads to double plasmonic resonances due to the Wood anomaly. We detail the fabrication process highlighting how the resist primer and the adhesion layer can reduce and impede the graphene doping due to the environment and to the nanopatches, respectively, by means of Raman spectroscopy. (C) 2013 AIP Publishing LLC. C1 [Grande, M.; Petruzzelli, V.; D'Orazio, A.] Politecn Bari, Dipartimento Ingn Elettr & Informaz, I-70125 Bari, Italy. [Stomeo, T.; De Vittorio, M.] IIT, Ctr Biomol Nanotechnol, I-73010 Lecce, Italy. [Bianco, G. V.; Bruno, G.] IMIP CNR, Inst Inorgan Methodol & Plasmas, I-70126 Bari, Italy. [Vincenti, M. A.; de Ceglia, D.] CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [De Vittorio, M.] Univ Salento, Ist Nansci, CNR, Dip Ingn Innovaz, I-73100 Lecce, Italy. [Scalora, M.] USA, Charles M Bowden Res Lab, AMRDEC, RDECOM, Redstone Arsenal, AL 35898 USA. RP Grande, M (reprint author), Politecn Bari, Dipartimento Ingn Elettr & Informaz, Via Re David 200, I-70125 Bari, Italy. RI Petruzzelli, Vincenzo/E-5576-2015; Petruzzelli, Vincenzo/H-5188-2012; De Vittorio, Massimo/I-5250-2012; OI BRUNO, GIOVANNI/0000-0003-3116-1176; Petruzzelli, Vincenzo/0000-0001-6921-9981; Petruzzelli, Vincenzo/0000-0001-6921-9981; De Vittorio, Massimo/0000-0003-1601-6392; BIANCO, GIUSEPPE VALERIO/0000-0002-0986-1531 FU U.S. Army International Technology Center Atlantic [W911NF-12-1-0292] FX M. Grande thanks the U.S. Army International Technology Center Atlantic for financial support (W911NF-12-1-0292). This research was performed while the authors M. A. Vincenti and D. de Ceglia held a National Research Council Research Associateship awards at the U.S. Army Aviation and Missile Research Development and Engineering Center. NR 27 TC 9 Z9 9 U1 2 U2 33 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 10 PY 2013 VL 102 IS 23 AR 231111 DI 10.1063/1.4810785 PG 5 WC Physics, Applied SC Physics GA 167HQ UT WOS:000320622600011 ER PT J AU Matyas, GR Mayorov, AV Rice, KC Jacobson, AE Cheng, KJ Iyer, MR Li, FY Beck, Z Janda, KD Alving, CR AF Matyas, Gary R. Mayorov, Alexander V. Rice, Kenner C. Jacobson, Arthur E. Cheng, Kejun Iyer, Malliga R. Li, Fuying Beck, Zoltan Janda, Kim D. Alving, Carl R. TI Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs SO VACCINE LA English DT Article DE Liposomes containing monophosphoryl lipid A; Adjuvant system; Opiate vaccine; Antibodies to heroin haptens ID MORPHINE/HEROIN VACCINE; ALUMINUM-HYDROXIDE; DRUG-ABUSE; PEPTIDES; SPECIFICITIES; CHOLESTEROL; ANTIGENS; CODEINE; RELAPSE; RATS AB In order to create an effective immunization approach for a potential vaccine to heroin, liposomes containing monophosphoryl lipid A [L(MPLA)] were tested as an adjuvant system to induce antibodies to heroin hapten analogs. Four synthetic haptens and two immunization strategies were employed. In the first strategy, a hydrophobic 23 amino acid immunogenic peptide derived from the membrane proximal external region of gp41 from HIV-1 envelope protein was embedded as a carrier in the outer surface of L(MPLA), to which was conjugated a 15 amino acid universal T cell epitope and a terminal heroin hapten analog. In the second strategy, tetanus toxoid (TT) carrier protein was decorated with haptens by conjugation, and the hapten-conjugated protein was mixed with L(MPLA). After immunization of mice, each of the immunization strategies was effective for induction of IgG anti-hapten antibodies. The first immunization strategy induced a mean end-point IgG titer against one of two haptens tested of approximately 12,800; however, no detectable antibodies were induced against the liposome-associated HIV-1 carrier peptide. In the second immunization strategy, depending on the hapten used for decorating the TT, end-point IgG titers ranged from 100,000 to 6,500,000. In this strategy, in which hapten was conjugated to the TT, end-point IgG titers of 400,000 to the TT carrier were observed with each conjugate. However, upon mixing unconjugated TT with L(MPLA), anti-TT titers of 6,500,000 were observed. We conclude that L(MPLA) serves as a potent adjuvant for inducing antibodies to candidate heroin haptens. However, antibodies to the carrier peptide or protein were partly or completed inhibited by the presence of conjugated hapten. Published by Elsevier Ltd. C1 [Matyas, Gary R.; Mayorov, Alexander V.; Beck, Zoltan; Alving, Carl R.] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Mayorov, Alexander V.; Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Rice, Kenner C.; Jacobson, Arthur E.; Cheng, Kejun; Li, Fuying] NIDA, Chem Biol Res Branch, NIH, Rockville, MD 20852 USA. [Iyer, Malliga R.] NIAAA, NIH, Rockville, MD 20852 USA. [Janda, Kim D.] Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Janda, Kim D.] Scripps Res Inst, Dept Immunol, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Janda, Kim D.] Scripps Res Inst, Worm Inst Res & Med, La Jolla, CA 92037 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command (MRMC) [W81XWH-07-2-067]; MRMC [Y1-DA0121-01]; National Institute on Drug Abuse [Y1-DA0121-01]; NIH Intramural Research Program of the National Institute on Drug Abuse; NIH Intramural Research Program of the National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS; NIH [DA 026625] FX This work was supported through a Cooperative Agreement Award (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The work was partially supported by an interagency agreement (Y1-DA0121-01 to CRA) between MRMC and the National Institute on Drug Abuse. The work of KC, FL, MRI, AEJ, and KCR was supported by the NIH Intramural Research Programs of the National Institute on Drug Abuse and the National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS. KJ was supported in part by NIH grant no. DA 026625. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adhered to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. NR 40 TC 18 Z9 18 U1 0 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 10 PY 2013 VL 31 IS 26 BP 2804 EP 2810 DI 10.1016/j.vaccine.2013.04.027 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 168ZD UT WOS:000320745600004 PM 23624097 ER PT J AU Brozena, A AF Brozena, Ann TI Vapor pressure of 1-octanol below 5 kPa using DSC SO THERMOCHIMICA ACTA LA English DT Article DE Vapor pressure; DSC; Differential scanning calorimetry; Thermal analysis; ASTM; Pinhole method AB American Society for Testing and Materials (ASTM) Method E 1782-08, Standard Test Method for Determining Vapor Pressure by Thermal Analysis recommends use of hermetic-type sealable sample pans with a single 50-75 mu m pinhole in the lid for pressures between 5 kPa and 2 MPa. At pressures below 5 kPa using the recommended pinhole range, boiling endotherms become increasingly broad. Earlier studies demonstrated qualitative improvement in endotherm sharpness with use of larger pinholes (up to 350 mu m) at pressures below 5 kPa. In the current work, the vapor pressure of 1-octanol was determined in accordance with ASTM E 1782-08 using pinholes ranging from 75 to 350 mu m from atmospheric pressure down to 0.197 kPa. These results clearly indicate that vapor pressure data in good agreement with the literature can be produced for 1-octanol at pressures as low as 0.2 kPa if pinhole sizes up to 350 mu m are used; the results are comparable to those generated using the current ASTM-recommended pressure and pinhole parameters. Published by Elsevier B.V. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Brozena, A (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM ann.brozena.civ@mail.mil NR 12 TC 9 Z9 9 U1 3 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0040-6031 J9 THERMOCHIM ACTA JI Thermochim. Acta PD JUN 10 PY 2013 VL 561 BP 72 EP 76 DI 10.1016/j.tca.2013.03.018 PG 5 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA 153YN UT WOS:000319638800010 ER PT J AU Umezu, I Warrender, JM Charnvanichborikarn, S Kohno, A Williams, JS Tabbal, M Papazoglou, DG Zhang, XC Aziz, MJ AF Umezu, Ikurou Warrender, Jeffrey M. Charnvanichborikarn, Supakit Kohno, Atsushi Williams, James S. Tabbal, Malek Papazoglou, Dimitris G. Zhang, Xi-Cheng Aziz, Michael J. TI Emergence of very broad infrared absorption band by hyperdoping of silicon with chalcogens SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MICROSTRUCTURED SILICON; DOPED SILICON; SULFUR; FEMTOSECOND AB We report the near through mid-infrared (MIR) optical absorption spectra, over the range 0.05-1.3 eV, of monocrystalline silicon layers hyperdoped with chalcogen atoms synthesized by ion implantation followed by pulsed laser melting. A broad mid-infrared optical absorption band emerges, peaking near 0.5 eV for sulfur and selenium and 0.3 eV for tellurium hyperdoped samples. Its strength and width increase with impurity concentration. Its strength decreases markedly with subsequent thermal annealing. The emergence of a broad MIR absorption band is consistent with the formation of an impurity band from isolated deep donor levels as the concentration of chalcogen atoms in metastable local configurations increases. (C) 2013 AIP Publishing LLC. C1 [Umezu, Ikurou] Konan Univ, Dept Phys, Kobe, Hyogo 6588501, Japan. [Warrender, Jeffrey M.] US Army, ARDEC Benet Labs, Watervliet, NY 12189 USA. [Charnvanichborikarn, Supakit; Williams, James S.] Australian Natl Univ, Res Sch Phys & Engn, Canberra, ACT 0200, Australia. [Kohno, Atsushi] Fukuoka Univ, Dept Appl Phys, Fukuoka 8140180, Japan. [Tabbal, Malek] Amer Univ Beirut, Dept Phys, Beirut 11072020, Lebanon. [Papazoglou, Dimitris G.] Fdn Res & Technol Hellas, Inst Elect Struct & Laser, Iraklion 71110, Greece. [Papazoglou, Dimitris G.] Univ Crete, Mat Sci & Technol Dept, Iraklion 71003, Greece. [Zhang, Xi-Cheng] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Aziz, Michael J.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Umezu, I (reprint author), Konan Univ, Dept Phys, Kobe, Hyogo 6588501, Japan. RI Papazoglou, Dimitris/D-9146-2013; Zhang, Xi-Cheng/G-1306-2016 OI Papazoglou, Dimitris/0000-0003-4537-5108; Zhang, Xi-Cheng/0000-0003-3721-1357 FU Fulbright Program; U.S. Army ARDEC [W15QKN-07-P-0092]; Japan Society for the Promotion of Science; Australian Research Council FX The authors gratefully acknowledge technical assistance from Yunqing Chen and helpful conversations with D. Recht, M. Winkler, J. Carey, P. Persans, and E. Mazur, and are grateful to D. Recht for assistance with manuscript preparation. M. T. acknowledges the financial support of the Fulbright Program. This research was supported in part by the U.S. Army ARDEC under Contract No. W15QKN-07-P-0092, and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. The Australian Research Council is also acknowledged for partial financial support. NR 28 TC 19 Z9 19 U1 1 U2 37 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 7 PY 2013 VL 113 IS 21 AR 213501 DI 10.1063/1.4804935 PG 7 WC Physics, Applied SC Physics GA 167ZQ UT WOS:000320674500017 ER PT J AU Vignes, RM Becker, R Stolken, J Kumar, M AF Vignes, Ryan M. Becker, Richard Stoelken, James Kumar, Mukul TI An assessment of diamond anvil cell measurements on material strength SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH-PRESSURE CELLS; HYDROSTATIC-PRESSURE; ULTRAHIGH PRESSURES; FLOW-STRESS; FRICTION; COMPRESSION; COEFFICIENT; TECHNOLOGY; ASPERITY; METAL AB Diamond anvil cell (DAC) experiments have been used in various studies to determine plastic flow strength in ductile metals at high pressure. To gain insight into the experiments and assess how accurately the material's strength at pressure can be determined, finite element simulations of DAC experiments are performed. In the analyses, constitutive responses are assumed for the diamonds and the vanadium test specimen; within the constitutive models, the pressure dependence of the strength is prescribed. The quantities typically measured during experiments are extracted from the simulations and analyzed in an identical manner as the experimental data would be to obtain the pressure dependent flow strength. This computed pressure dependent strength is then compared with the prescribed input, allowing the accuracy and sensitivities of the experimental technique to be evaluated. Recommendations are made to improve the accuracy of strength determinations. (C) 2013 AIP Publishing LLC. C1 [Vignes, Ryan M.; Stoelken, James; Kumar, Mukul] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. [Becker, Richard] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vignes, RM (reprint author), Lawrence Livermore Natl Lab, POB 808, Livermore, CA 94551 USA. EM mukul@llnl.gov RI Becker, Richard/I-1196-2013 FU U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. NR 31 TC 2 Z9 2 U1 2 U2 33 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 7 PY 2013 VL 113 IS 21 AR 213503 DI 10.1063/1.4807786 PG 10 WC Physics, Applied SC Physics GA 167ZQ UT WOS:000320674500019 ER PT J AU Yang, SC Sanghadasa, M Priya, S AF Yang, Su Chul Sanghadasa, Mohan Priya, Shashank TI Highly ordered Pb(Zr0.52Ti0.48)O-3 piezoelectric nanorod arrays SO NANOTECHNOLOGY LA English DT Article ID NANOWIRE ARRAYS; NANOTUBES; NANOSTRUCTURES; NANOFIBERS AB One-dimensional (1D) piezoelectric nanostructures have attracted significant attention for a broad range of applications including optoelectronics, thermoelectrics, electrochemical and electromechanical converters. We demonstrate the synthesis of 1D nanostructures based upon Pb(Zr0.52Ti0.48)O-3 (PZT) on conductive substrates via sol-gel template synthesis. The vertically aligned PZT nanostructures with heights around one micron were synthesized by vacuum infiltration of sol-gel precursors into highly ordered cylindrical pores of anodized aluminum oxide templates. The 1D nanostructures were developed on large scale platinized silicon wafers and exhibited dense rod-like structure with a uniform diameter of 90 nm and an aspect ratio of 10. Scanning probe microscopy conducted on individual nanorods demonstrated good electromechanical properties with a high piezoelectric magnitude of 41 pm V-1. We believe that this study opens the possibility of developing high performance nanoscale piezoelectric sensors and transducers. C1 [Yang, Su Chul; Priya, Shashank] Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA. [Sanghadasa, Mohan] USA, Weap Sci Directorate, Aviat & Missile Res Dev & Engn Ctr, RDECOM, Redstone Arsenal, AL 35898 USA. RP Yang, SC (reprint author), Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA. EM spriya@vt.edu FU US Army Aviation and Missile Research, Development, and Engineering Center through CEHMS FX We gratefully acknowledge the financial support from US Army Aviation and Missile Research, Development, and Engineering Center through CEHMS seed program. The authors would sincerely like to thank Dr Ashok Kumar for his valuable contributions in revising the manuscript and helping with the submission. NR 28 TC 1 Z9 1 U1 4 U2 52 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD JUN 7 PY 2013 VL 24 IS 22 AR 225303 DI 10.1088/0957-4484/24/22/225303 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 149NH UT WOS:000319326600008 PM 23637024 ER PT J AU Sedegah, M Kim, Y Ganeshan, H Huang, J Belmonte, M Abot, E Banania, JG Farooq, F McGrath, S Peters, B Sette, A Soisson, L Diggs, C Doolan, DL Tamminga, C Villasante, E Hollingdale, MR Richie, TL AF Sedegah, Martha Kim, Yohan Ganeshan, Harini Huang, Jun Belmonte, Maria Abot, Esteban Banania, Jo Glenna Farooq, Fouzia McGrath, Shannon Peters, Bjoern Sette, Alessandro Soisson, Lorraine Diggs, Carter Doolan, Denise L. Tamminga, Cindy Villasante, Eileen Hollingdale, Michael R. Richie, Thomas L. TI Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP) SO MALARIA JOURNAL LA English DT Article DE Malaria; Vaccine; Circumsporozoite protein; ELISpot; Flow cytometry; NetMHC; Epitope mapping; Class I restriction; Localization ID I ALLELE PROMISCUITY; MALARIA DNA VACCINE; PEPTIDE-BINDING; HLA-A; SUPERTYPES; MOLECULES; RESPONSES; ANTIGENS; IMMUNOGENICITY; POLYMORPHISM AB Background: Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS, S vaccine). Recently, a DNA prime/adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1, also elicited sterile protection, but in this case associated with interferon gamma ELISpot and CD8+ T cell but not antibody responses. The finding that CSP delivered by an appropriate vaccine platform likely elicits protective cell-mediated immunity provided a rationale for identifying class I-restricted epitopes within this leading vaccine candidate antigen. Methods: Limited samples of peripheral blood mononuclear cells from clinical trials of the Ad vaccine were used to identify CD8+ T cell epitopes within pools of overlapping 15mer peptides spanning portions of CSP that stimulated recall responses. Computerized algorithms (NetMHC) predicted 17 minimal class I-restricted 9-10mer epitopes within fifteen 15mers positive in ELISpot assay using PBMC from 10 HLA-matched study subjects. Four additional epitopes were subsequently predicted using NetMHC, matched to other study subjects without initial 15mer ELISpot screening. Nine of the putative epitopes were synthesized and tested by ELISpot assay, and six of these nine were further tested for CD8+ T cell responses by ELISpot CD4+ and CD8+ T cell-depletion and flow cytometry assays for evidence of CD8+ T cell dependence. Results: Each of the nine putative epitopes, all sequence-conserved, recalled responses from HLA-matched CSP-immunized research subjects. Four shorter sequences contained within these sequences were identified using NetMHC predictions and may have contributed to recall responses. Five (9-10mer) epitopes were confirmed to be targets of CD8+ T cell responses using ELISpot depletion and ICS assays. Two 9mers among these nine epitopes were each restricted by two HLA supertypes (A01/B07; A01A24/A24) and one 9mer was restricted by three HLA supertypes (A01A24/A24/B27) indicating that some CSP class I-restricted epitopes, like DR epitopes, may be HLA-promiscuous. Conclusions: This study identified nine and confirmed five novel class I epitopes restricted by six HLA supertypes, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations. C1 [Sedegah, Martha; Ganeshan, Harini; Huang, Jun; Belmonte, Maria; Abot, Esteban; Banania, Jo Glenna; Farooq, Fouzia; McGrath, Shannon; Tamminga, Cindy; Villasante, Eileen; Hollingdale, Michael R.; Richie, Thomas L.] USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Kim, Yohan; Peters, Bjoern; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [Doolan, Denise L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA. RP Sedegah, M (reprint author), USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. EM martha.sedegah@med.navy.mil RI Doolan, Denise/F-1969-2015; OI Richie, Thomas/0000-0002-2946-5456 FU Naval Medical Research Center [6000.RAD1.F.A0309]; USAID; Military Infectious Diseases Research Program; Congressionally Directed Medical Research Program; Pfizer Australia FX CT, EV, and TLR were active duty military personnel at the time they contributed to this work; MS is a US Government employee. The work of these individuals was prepared as part of official government duties. Title 17 USC 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 USC 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. The work of authors affiliated with the Naval Medical Research Center was supported by work unit number 6000.RAD1.F.A0309. Major funding for this work was provided by USAID, the Military Infectious Diseases Research Program, and the Congressionally Directed Medical Research Program. DLD was supported by a Pfizer Australia Senior Research Fellowship. The study protocol for the clinical trial presented in this manuscript was approved by the National Naval Medical Center, Naval Medical Research Center and Walter Reed Army Institute of Research Institutional Review Boards, in compliance with all applicable federal regulations governing protection of human subjects. All study subjects gave written informed consent. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of the Army, the Department of Defense, or the US Government. We gratefully acknowledge the assistance of Jennifer Ng in the HLA typing of the research subjects. NR 62 TC 10 Z9 10 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 5 PY 2013 VL 12 AR 185 DI 10.1186/1475-2875-12-185 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 163WH UT WOS:000320367900001 PM 23738590 ER PT J AU Rigler, M Zgonik, M Hoffmann, MP Kirste, R Bobea, M Collazo, R Sitar, Z Mita, S Gerhold, M AF Rigler, Martin Zgonik, Marko Hoffmann, Marc P. Kirste, Ronny Bobea, Milena Collazo, Ramon Sitar, Zlatko Mita, Seiji Gerhold, Michael TI Refractive index of III-metal-polar and N-polar AlGaN waveguides grown by metal organic chemical vapor deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID LIGHT-EMITTING-DIODES; PRISM COUPLER; GAN; FILMS; ALXGA1-XN; TEMPERATURE; ALN; SUSCEPTIBILITIES; WAVELENGTH; GENERATION AB Optical waveguides of III-metal-polar and N-polar AlGaN are grown on sapphire substrates in order to test their use in integrated optics. The dispersion of the ordinary and extraordinary indices of refraction for films with aluminum mole fraction between 0.0 and 0.30 at four discrete wavelengths has been determined by the prism coupling method. The wavelength dependence of the refractive indices is described well by the first-order Sellmeier dispersion formula. The measurements show a small difference in the refractive indices between the two polarities, which is more pronounced at longer wavelengths. (C) 2013 American Institute of Physics. C1 [Rigler, Martin; Zgonik, Marko] Univ Ljubljana, Fac Math & Phys, Ljubljana 1000, Slovenia. [Rigler, Martin; Zgonik, Marko] Jozef Stefan Inst, Ljubljana 1000, Slovenia. [Hoffmann, Marc P.; Kirste, Ronny; Bobea, Milena; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27606 USA. [Mita, Seiji] HexaTech Inc, Morrisville, NC 27560 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Rigler, M (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia. EM martin.rigler@fmf.uni-lj.si RI Zgonik, Marko/K-9092-2015 OI Zgonik, Marko/0000-0002-2307-8797 FU Army Research Laboratory [W911NF-04-D-0003]; William Clark program monitor; NSF [DMR-1108071] FX The NCSU group acknowledges a partial financial support by the Army Research Laboratory, Contract No.: W911NF-04-D-0003, William Clark program monitor and NSF under Contract DMR-1108071. NR 45 TC 9 Z9 9 U1 3 U2 32 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 3 PY 2013 VL 102 IS 22 AR 221106 DI 10.1063/1.4800554 PG 5 WC Physics, Applied SC Physics GA 167HH UT WOS:000320621600006 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI Nasser's Gamble: How Intervention in Yemen Caused the Six-Day War and the Decline of Egyptian Power SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 2013 VL 67 IS 3 BP 478 EP 480 PG 3 WC Area Studies SC Area Studies GA AG2UU UT WOS:000335273400013 ER PT J AU Welton, MD AF Welton, Mark D. TI The Impossible State: Islam, Politics, and Modernity's Moral Predicament SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 2013 VL 67 IS 3 BP 492 EP 493 PG 2 WC Area Studies SC Area Studies GA AG2UU UT WOS:000335273400023 ER PT J AU Blair, JA Owens, JG Saucedo, J Hsu, JR AF Blair, James A. Owens, Johnny G. Saucedo, Joey Hsu, Joseph R. CA Skeletal Trauma Res TI Functional Rehabilitation With a Foot Plate Modification for Circular External Fixation SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Taylor spatial frame; Ilizarov; foot plate; limb salvage; Return To Run ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; TIBIAL FRACTURES; ILIZAROV METHOD; IRAQI FREEDOM; LIMB SALVAGE; DEFECTS; BONE; WOUNDS; REPAIR AB Background: Customized foot plates attached to the foot ring of an ankle-spanning circular external fixator present a unique opportunity for patients undergoing complex lower-extremity limb salvage to participate in highly advanced weight-bearing physical therapy. The purpose of this study was to identify the rehabilitation capabilities afforded by this external fixator modification. Methods: Surgical logs and radiographs were reviewed to identify all lower-extremity limb salvage patients from February 2008 to December 2010 treated with an ankle-spanning circular external fixator and a customized foot plate treated by the same orthopedic surgeon and enrolled in our institution's Return To Run clinical pathway. Medical records were reviewed to identify a series of exercises that each patient was able to perform. Results: Eleven patients were identified. All patients were treated by the same physical therapist. All 11 patients were able to bear full weight on their foot plates and perform regular and split squats. Six of 11 patients were able to ambulate unassisted, and 5 patients required a cane. All 11 patients could navigate stairs and use an elliptical and stair-stepping machine. Six of 11 patients could perform single-leg hack squats. Eight of 11 patients were able to perform double-leg shuttle jumps, although only 5 of 11 patients could perform single-leg shuttle jumps. Five of 11 patients were able to perform a single-leg balance. Only 1 patient was able to run on the foot plate. Conclusions: Patients undergoing lower-extremity limb salvage with an ankle-spanning circular external fixator and a customized foot plate were able to participate in highly advanced weight-bearing physical therapy exercises during the osseous and soft-tissue healing process. C1 [Blair, James A.; Saucedo, Joey] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Owens, Johnny G.] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] Carolinas Med Ctr, Charlotte, NC 28203 USA. [Skeletal Trauma Res] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Blair, JA (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM james.blair@amedd.army.mil FU United States Army Institute of Surgical Research; Combat Casualty Care Research Program FX The authors declared receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the United States Army Institute of Surgical Research and the Combat Casualty Care Research Program. NR 19 TC 2 Z9 2 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD JUN PY 2013 VL 34 IS 6 BP 890 EP 897 DI 10.1177/1071100713483975 PG 8 WC Orthopedics SC Orthopedics GA 298FI UT WOS:000330309100018 PM 23564426 ER PT J AU Secord, AA Barnett, JC Ledermann, JA Peterson, BL Myers, ER Havrilesky, LJ AF Secord, Angeles Alvarez Barnett, Jason Cory Ledermann, Jonathan A. Peterson, Bercedis L. Myers, Evan R. Havrilesky, Laura J. TI Cost-Effectiveness of BRCA1 and BRCA2 Mutation Testing to Target PARP Inhibitor Use in Platinum-Sensitive Recurrent Ovarian Cancer SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE Biomarkers; PARP inhibitors; Ovarian cancer; Cost-effectiveness ID BREAST-CANCER; AMERICAN-SOCIETY; POLY(ADP-RIBOSE) POLYMERASE; GENE-MUTATIONS; CARCINOMA; THERAPY; RECOMMENDATIONS; TRASTUZUMAB; BEVACIZUMAB; POPULATION AB Objectives: (1) To determine whether use of a PARP inhibitor or (2) BRCA1/2 mutation testing followed by a PARP inhibitor for test positives is potentially cost-effective for maintenance treatment of platinum-sensitive recurrent high-grade serous ovarian cancer. Methods: A modified Markov decision analysis compared 3 strategies: (1) observe; (2) olaparib to progression; (3) BRCA1/2 mutation testing; treat mutation carriers with olaparib to progression. Progression-free survival and rates of adverse events were derived from a phase 2 randomized trial. Key assumptions are as follows: (1) 14% of patients harbor a BRCA1/2 mutation; (2) progression-free survival of individuals treated with olaparib is improved for BCRA1/2 carriers compared with noncarriers (estimated hazard ratio, approximately 0.4). Costs derived from national data were assigned to treatments, adverse events, and BRCA1/2 test. Monte Carlo probabilistic sensitivity analysis was performed. Results: Global olaparib was the most effective strategy, followed by BRCA1/2 testing and no olaparib. BRCA1/2 testing had an incremental cost-effectiveness ratio (ICER) of $193,442 per progression-free year of life saved (PF-YLS) compared to no olaparib, whereas global olaparib had an ICER of $234,128 per PF-YLS compared to BRCA1/2 testing. At a 52% lower-than-baseline olaparib cost estimate of $3000 per month, BRCA1/2 testing became potentially cost-effective compared with observation, with an ICER of $100,000 per PF-YLS. When strategy (1) was removed from the analysis, BRCA1/2 testing was the preferred strategy. Conclusions: The use of maintenance olaparib in women with high-grade serous ovarian cancer is not cost-effective regardless of whether BRCA1/2 testing is used to direct treatment. However, BRCA1/2 testing is a preferred strategy compared to global maintenance olaparib alone. C1 [Secord, Angeles Alvarez; Havrilesky, Laura J.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA. [Barnett, Jason Cory] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. [Ledermann, Jonathan A.] UCL Canc Inst, London, England. [Ledermann, Jonathan A.] Biomed Res Ctr, London, England. [Peterson, Bercedis L.] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27710 USA. [Myers, Evan R.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Clin & Epidemiol Res, Durham, NC 27710 USA. RP Secord, AA (reprint author), Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, DUMC 3079, Durham, NC 27710 USA. EM secor002@mc.duke.edu NR 28 TC 7 Z9 8 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1048-891X EI 1525-1438 J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD JUN PY 2013 VL 23 IS 5 BP 846 EP 852 DI 10.1097/IGC.0b013e31829527bd PG 7 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 299CU UT WOS:000330373500013 PM 23666017 ER PT J AU Atkins, AF AF Atkins, Alison F. TI FROM A DREAM TO A REALITY CHECK: PROTECTING THE RIGHTS OF TOMORROW'S CONDITIONAL LEGAL RESIDENT ENLISTEES SO MILITARY LAW REVIEW LA English DT Article C1 [Atkins, Alison F.] US Army, Adelphi, MD USA. [Atkins, Alison F.] 1st Armored Div, Wiesbaden, Germany. [Atkins, Alison F.] Patton Legal Ctr, Heidelberg, Germany. RP Atkins, AF (reprint author), 10th Mt Div Light Infantry, Criminal Law Div, Ft Drum, NY 13602 USA. NR 66 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2013 VL 216 BP 1 EP 76 PG 76 WC Law SC Government & Law GA 299UB UT WOS:000330420100001 ER PT J AU Sykes, MSC AF Sykes, Major Sarah C. TI "DEFENSE COUNSEL, PLEASE RISE": A COMPARATIVE ANALYSIS OF TRIAL IN ABSENTIA SO MILITARY LAW REVIEW LA English DT Article C1 [Sykes, Major Sarah C.] US Army, Charlottesville, VA 22901 USA. RP Sykes, MSC (reprint author), US Army, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 39 TC 0 Z9 0 U1 3 U2 3 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2013 VL 216 BP 170 EP 211 PG 42 WC Law SC Government & Law GA 299UB UT WOS:000330420100004 ER PT J AU Finan, PH Quartana, PJ Smith, MT AF Finan, Patrick H. Quartana, Phillip J. Smith, Michael T. TI Positive and Negative Affect Dimensions in Chronic Knee Osteoarthritis: Effects on Clinical and Laboratory Pain SO PSYCHOSOMATIC MEDICINE LA English DT Article DE positive affect; negative affect; chronic pain; daily diary; quantitative sensory testing; temporal summation ID FIBER-EVOKED PAIN; SLOW TEMPORAL SUMMATION; FIBROMYALGIA PATIENTS; WIND-UP; POLYMORPHISM 5-HTTLPR; SLEEP DISTURBANCE; HEALTH COMPLAINTS; SHOULDER PAIN; OLDER-ADULTS; ARTHRITIS AB Objective: This study investigated whether daily and laboratory assessed pain differs as a function of the temporal stability and valence of affect in individuals with chronic knee osteoarthritis (KOA). Methods: One hundred fifty-one men and women with KOA completed 14 days of electronic diaries assessing positive affect (PA), negative affect (NA), and clinical pain. A subset of participants (n = 79) engaged in quantitative sensory testing (QST). State PA and NA were assessed prior to administration of stimuli that induced suprathreshold pain and temporal summation. Multilevel modeling and multiple regression evaluated associations of affect and pain as a function of valence (i.e., positive versus negative) and stability (i.e., stable versus state). Results: In the diary, stable NA (B = -.63, standard error [SE] = .13, p < .001) was a stronger predictor of clinical KOA pain than stable PA (B = -.18, SE = .11, p = .091), and state PA (B = -.09, p < .001) was a stronger predictor of concurrent daily clinical pain than state NA (B = .04, SE = .02, p = .068). In the laboratory, state PA (B = -.05, SE = .02, p = .042), but not state NA (p = .46), predicted diminished temporal summation of mechanical pain. Conclusions: Stable NA is more predictive of clinical pain than stable PA, whereas state PA is more predictive of both clinical and laboratory pain than state NA. The findings suggest that dynamic affect-pain processes in the field may reflect individual differences in central pain facilitation. C1 [Finan, Patrick H.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Finan, PH (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. EM pfinan1@jhu.edu FU NIH [R01 AR05487, R01AR059410, T32 NS070201] FX Funding for work on the current study was provided by NIH R01 AR05487 (M.T.S.), NIH R01AR059410 (M.T.S.), and NIH T32 NS070201 (P.H.F.). The authors declare no conflicts of interest. NR 68 TC 13 Z9 14 U1 4 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 EI 1534-7796 J9 PSYCHOSOM MED JI Psychosom. Med. PD JUN PY 2013 VL 75 IS 5 BP 463 EP 470 DI 10.1097/PSY.0b013e31828ef1d6 PG 8 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 300MO UT WOS:000330468200005 PM 23697467 ER PT J AU Crete, JE Anasti, JN AF Crete, Joan E. Anasti, James N. TI Diagnosis of gestational diabetes mellitus: Can we avoid the glucose challenge test? SO JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS LA English DT Article DE Diabetes; risk factors; screening; obstetrics and gynecology (OB/GYN) ID SCREENING-TESTS; CRITERIA; PREGNANCY; GUIDELINES; MANAGEMENT AB Objective: To identify risk factors for gestational diabetes mellitus (GDM) in patients who had either a normal or abnormal glucose tolerance test (GTT) after failing the initial glucose challenge test (GCT). If identified, consideration can be given to circumvent the glucose challenge test for those at risk. Data sources: A chart review was performed on 557 patients with abnormal GCT, 278 had an abnormal GTT (cases), and 279 had normal GTT (controls). The following risk factors were extracted: patients' age, body mass index (BMI), ethnicity, selected personal history, and family history. A primary logistic regression and secondary exploratory logistic regression were used to analyze the data. Conclusions: Of the risk factors reviewed age, BMI, and prior history of GDM were predictive of GDM in the current pregnancy. Age 30-34 had an odds ratio (OR) of 1.95, 95% confidence interval (CI) [1.25,3.05] and over 35 had an OR 3.87 CI [2.12,7.05]. BMI over 30 had an OR 1.95, CI [1.25,3.05] and prior GDM had an OR 2.82 CI [1.55,5.13]. The combination of age and BMI had a significant OR, but not a significant increase over individual risk factors. Implications for practice: Screening by risk factors to circumvent glucose challenge testing may cause unnecessary testing and cost. C1 [Crete, Joan E.; Anasti, James N.] St Lukes Hosp & Hlth Network, Dept Obstet & Gynecol, Bethlehem, PA USA. RP Crete, JE (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM joan.e.crete@us.army.mil NR 26 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2327-6886 EI 2327-6924 J9 J AM ASSOC NURSE PRA JI J. Am. Assoc. Nurs. Pract. PD JUN PY 2013 VL 25 IS 6 BP 329 EP 333 DI 10.1111/j.1745-7599.2012.00792.x PG 5 WC Health Care Sciences & Services; Nursing SC Health Care Sciences & Services; Nursing GA 296GR UT WOS:000330173700008 PM 24170598 ER PT J AU Belenkiy, S Berry, J Batchinsky, A Kendrick, C Necsoiu, C Salinas, J Cancio, L AF Belenkiy, S. Berry, J. Batchinsky, A. Kendrick, C. Necsoiu, C. Salinas, J. Cancio, L. TI UTILITY OF END-TIDAL AND TRANSCUTANEOUS CARBON DIOXIDE MONITORING DURING LETHAL HEMORRHAGIC SHOCK SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Belenkiy, S.; Berry, J.; Batchinsky, A.; Kendrick, C.; Necsoiu, C.; Salinas, J.; Cancio, L.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Belenkiy, S.; Berry, J.; Kendrick, C.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 44 EP 45 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500090 ER PT J AU Dubick, MA Darlington, DN Barr, JJ Grubbs, DL Schwacha, MG Cap, AP AF Dubick, M. A. Darlington, D. N. Barr, J. J. Grubbs, D. L. Schwacha, M. G. Cap, A. P. TI EFFECTS OF POLYTRAUMA, HEMORRHAGE AND RESULTANT COAGULOPATHY ON INFLAMMATORY AND OXIDANT STRESS MARKERS IN RAT TISSUES SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Dubick, M. A.; Darlington, D. N.; Barr, J. J.; Grubbs, D. L.; Schwacha, M. G.; Cap, A. P.] US Army, Inst Surg Res, San Antonio, TX USA. [Dubick, M. A.; Schwacha, M. G.; Cap, A. P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 44 EP 44 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500089 ER PT J AU Tiba, MH Draucker, GT Barbee, RW Terner, J Torres, IP Ward, KR AF Tiba, M. H. Draucker, G. T. Barbee, R. W. Terner, J. Torres Filho, I. P. Ward, K. R. TI PERFORMANCE OF TISSUE HEMOGLOBIN OXYGEN SATURATION AS MEASURED BY RESONANCE RAMAN SPECTROSCOPY AND NEAR INFRARED SPECTROSCOPY COMPARED TO MIXED VENOUS HEMOGLOBIN OXYGEN SATURATION AND SYSTEMIC LACTATE LEVELS DURING HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Tiba, M. H.; Draucker, G. T.; Ward, K. R.] Univ Michigan, Ann Arbor, MI 48109 USA. [Tiba, M. H.; Draucker, G. T.; Ward, K. R.] Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI USA. [Barbee, R. W.; Terner, J.] Virginia Commonwealth Univ, Richmond, VA USA. [Torres Filho, I. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 56 EP 56 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500123 ER PT J AU Zhang, Q Rani, M Cap, AP Darlington, DN Schwacha, MG AF Zhang, Q. Rani, M. Cap, A. P. Darlington, D. N. Schwacha, M. G. TI BURN INCREASES CIRCULATING LEVELS OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS (DAMPS) SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Zhang, Q.; Rani, M.; Cap, A. P.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Cap, A. P.; Darlington, D. N.; Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 57 EP 57 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500125 ER PT J AU Holloway, TL Rani, M Craig, T Zhang, Q Cap, AP Schwacha, MG AF Holloway, T. L. Rani, M. Craig, T. Zhang, Q. Cap, A. P. Schwacha, M. G. TI TOLL-LIKE RECEPTOR INDUCED RESPONSES BY CIRCULATING LEUKOCYTES ARE SUPPRESSED IN TRAUMA ICU PATIENTS SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Holloway, T. L.; Rani, M.; Craig, T.; Zhang, Q.; Cap, A. P.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Cap, A. P.; Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 81 EP 81 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500191 ER PT J AU Berry, JS Batchinsky, A Belenkiy, S Kendrick, C Necsoiu, C Ivey, KM Thomas, D Dubick, MA Salinas, J Rasmussen, TE Cancio, L AF Berry, J. S. Batchinsky, A. Belenkiy, S. Kendrick, C. Necsoiu, C. Ivey, K. M. Thomas, D. Dubick, M. A. Salinas, J. Rasmussen, T. E. Cancio, L. TI A PORCINE MODEL OF EXSANGUINATION CARDIAC ARREST SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Berry, J. S.; Batchinsky, A.; Belenkiy, S.; Kendrick, C.; Necsoiu, C.; Ivey, K. M.; Thomas, D.; Dubick, M. A.; Salinas, J.; Rasmussen, T. E.; Cancio, L.] US Army, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 92 EP 92 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500220 ER PT J AU Rani, M Galvan, EM Zhang, Q Schwacha, MG AF Rani, M. Galvan, E. M. Zhang, Q. Schwacha, M. G. TI TRAUMA-HEMORRHAGE-INDUCED ACUTE LUNG INJURY IS ASSOCIATED WITH T-CELL-MEDIATED TH2 AND TH17 IMMUNE RESPONSES SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Rani, M.; Galvan, E. M.; Zhang, Q.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schwacha, M. G.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 93 EP 93 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500223 ER PT J AU Baer, LA Wu, X Wolf, S Wade, C AF Baer, L. A. Wu, X. Wolf, S. Wade, C. TI ADIPOKINE RESPONSES TO BURN AND DISUSE IN RATS SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Baer, L. A.; Wade, C.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Wu, X.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Wolf, S.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 95 EP 95 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500228 ER PT J AU Martini, AK Moreno, C Guerra, J Martini, W Dubick, MA AF Martini, A. K. Moreno, C. Guerra, J. Martini, W. Dubick, M. A. TI DOSE RESPONSES OF ACETAMINOPHEN AND MELOXICAM ON PLATELET AGGREGATION AND COAGULATION IN HUMAN BLOOD IN VITRO SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Martini, A. K.] Rice Univ, Houston, TX USA. [Moreno, C.; Guerra, J.; Martini, W.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 96 EP 97 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500232 ER PT J AU Martini, W Cortex, D Dubick, MA AF Martini, W. Cortex, D. Dubick, M. A. TI RESUSCITATION EFFECTS OF LACTATED RINGER'S SOLUTION AND NORMAL SALINE ON EARLY HEPATIC SYNTHESIS FOLLOWING SEVERE HEMORRHAGIC SHOCK IN PIGS SO SHOCK LA English DT Meeting Abstract CT 36th Annual Conference of Shock-Society on Shock CY JUN 01-04, 2013 CL San Diego, CA SP Shock Soc C1 [Martini, W.; Cortex, D.; Dubick, M. A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 SU 2 BP 104 EP 104 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297JK UT WOS:000330251500252 ER PT J AU Seibert, J Roofe, SB AF Seibert, Jared Roofe, Scott B. TI Pilot Study of Dexmedetomidine in Promoting Patient Comfort without Airway Compromise during Awake Tracheotomy SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE awake tracheotomy; dexmedetomidine; patient safety; difficult airway ID SEDATION C1 [Seibert, Jared; Roofe, Scott B.] US Army, Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Seibert, J (reprint author), US Army, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Jared.seibert@amedd.army.mil NR 5 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUN PY 2013 VL 148 IS 6 BP 1051 EP 1053 DI 10.1177/0194599813484448 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 285ZD UT WOS:000329433000025 PM 23554116 ER PT J AU Ward, MP Sperry, JH Weatherhead, PJ AF Ward, Michael P. Sperry, Jinelle H. Weatherhead, Patrick J. TI Evaluation of Automated Radio Telemetry for Quantifying Movements and Home Ranges of Snakes SO JOURNAL OF HERPETOLOGY LA English DT Article ID EASTERN MASSASAUGA RATTLESNAKES; HUMAN DISTURBANCE; ESTIMATORS; SIZE; RADIOTELEMETRY; ECOLOGY AB We evaluated an automated telemetry system that can dramatically increase the amount of activity and spatial data collected for snakes. We developed methods for analyzing data from single automated receiving units (ARUs) and ARU arrays, compared results from ARUs with conventional hand tracking, and assessed previously untested assumptions used in conventional telemetry, using data from ratsnakes (Pantherophis spp.) in Texas and Illinois. ARU data indicated that ratsnakes spent most of their time in small home ranges (mean = 25 ha) but engaged in forays of up to 1.5 km from their core-use areas, suggesting this species may engage in central place foraging. Forays inflated home-range sizes greatly if areas were estimated using minimum convex polygons rather than 95% kernels. Large numbers of locations generated by ARUs produce more reliable home-range estimates than those from hand tracking. ARU data indicated that snakes moved in response to observers during hand tracking. Daily hand tracking produced reliable estimates of distances moved but underestimated distances by a factor of 4 when snakes were tracked every 5 days. Drawbacks of ARUs are that the error associated with individual locations exceeds that for hand-tracked locations and that the costs exceed those for hand tracking. Automated receivers can increase data greatly from radio-tracked snakes, providing novel insights unavailable from conventional hand tracking. There are drawbacks to this technology, some of which will vary among study species; therefore, researchers should evaluate the appropriateness of the technology for both the study species and the questions being asked. C1 [Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Ward, Michael P.] Univ Illinois, Illinois Nat Hist Survey, Champaign, IL 61802 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Ward, MP (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM mpward@illinois.edu FU U.S. Army Fort Hood Natural Resources Branch; U.S. Army Corps of Engineers, Engineer Research and Development Center FX For the Texas portion of this project, we thank the U.S. Army Fort Hood Natural Resources Branch and the U.S. Army Corps of Engineers, Engineer Research and Development Center for funding, particularly J. Cornelius, T. Hayden, and T. Buchanan. For the Illinois portion, we thank M. Alessi, H. Fraser, K. Sierzega, S. Chiavacci, E. Swenson, T. Dallas, T. Beveroth, A. Raim, Vermilion County Conservation District, and the Illinois Department of Natural Resources for assistance in the field and access of the study area. We thank T. J. Benson for assistance with statistical analyses. NR 28 TC 16 Z9 16 U1 4 U2 48 PU SOC STUDY AMPHIBIANS REPTILES PI ST LOUIS PA C/O ROBERT D ALDRIDGE, ST LOUIS UNIV, DEPT BIOLOGY, 3507 LACLEDE, ST LOUIS, MO 63103 USA SN 0022-1511 EI 1937-2418 J9 J HERPETOL JI J. Herpetol. PD JUN PY 2013 VL 47 IS 2 BP 337 EP 345 DI 10.1670/12-018 PG 9 WC Zoology SC Zoology GA 264TI UT WOS:000327903500021 ER PT J AU Zheng, ZL Badawy, T Henein, N Sattler, E AF Zheng, Ziliang Badawy, Tamer Henein, Naeim Sattler, Eric TI Investigation of Physical and Chemical Delay Periods of Different Fuels in the Ignition Quality Tester SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article AB This paper investigates the physical and chemical ignition delay (ID) periods in the constant volume combustion chamber of the Ignition Quality Tester (IQT). IQT was used to determine the derived cetane number (DCN) according to ASTM D6890-10a standards. The fuels tested were ultra low sulfur diesel (ULSD), jet propellant-8 (JP-8), and two synthetic fuels of Sasol IPK and F-T SPK (S-8). A comparison was made between the DCN and cetane number (CN) determined according to ASTM-D613 standards. Tests were conducted under steady state conditions at a constant pressure of 21 bars and various air temperatures ranging from 778K to 848 K. The rate of heat release (RHR) was calculated from the measured pressure trace, and a detailed analysis of the RHR trace was made particularly for the auto-ignition process. Tests were conducted to determine the physical and chemical delay periods by comparing results obtained from two tests. In the first test, the fuel was injected into air according to ASTM standards. In the second test, the fuel was injected into nitrogen. The point at which the two resultant pressure traces separated was considered to be the end of the physical delay period. The effects of the charge temperature on the total ID as defined in ASTM D6890-10a standards, as well as on the physical and chemical delays, were determined. It was noticed that the physical delay represented a significant part of the total ID over all the air temperatures covered in this investigation. Arrhenius plots were developed to determine the apparent activation energy for each fuel using different IDs. The first was based on the total ID measured according to ASTM standards. The second was the chemical delay determined in this investigation. The activation energy calculated from the total ID showed higher values for lower CN fuels except Sasol IPK. The activation energy calculated from the chemical delay period showed consistency in the increase of the activation energy with the drop in CN including Sasol IPK. The difference between the two findings could be explained by examining the sensitivity of the physical delay period of different fuels to the change in air temperature. C1 [Zheng, Ziliang; Badawy, Tamer; Henein, Naeim] Wayne State Univ, Detroit, MI 48202 USA. [Sattler, Eric] US Army RDECOM TARDEC, Warren, MI 48092 USA. RP Zheng, ZL (reprint author), Wayne State Univ, Detroit, MI 48202 USA. EM zhengziliang@gmail.com; Eng.tam@gmail.com; henein@eng.wayne.edu; eric.r.sattler.civ@mail.mil FU US Army TARDEC; NAC, US Department of Energy, Next Energy Center and Automotive Research Center (ARC): A Center of Excellence in Simulation and Modeling FX This research was sponsored by US Army TARDEC and NAC, US Department of Energy, Next Energy Center and Automotive Research Center (ARC): A Center of Excellence in Simulation and Modeling sponsored by US Army TARDEC and lead by University of Michigan. Our special thanks are to Pat Muzzell and N. Johnson of NAC, P. Schihl and L Hoogterp-Decker of TARDEC, Kapila Wadumesthrige and Elena Florea for their technical support. We also would like to thank National Renewable Energy Lab, Wayne State University Center of Automotive Research members for their help in conducting this research. NR 42 TC 10 Z9 10 U1 0 U2 8 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 EI 1528-8919 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUN PY 2013 VL 135 IS 6 AR 061501 DI 10.1115/1.4023607 PG 11 WC Engineering, Mechanical SC Engineering GA 241GY UT WOS:000326155600002 ER PT J AU George, SG Slack, WT Killgore, KJ AF George, Steven G. Slack, William T. Killgore, K. Jack TI First Recorded Occurrence of Oncorhynchus mykiss (Rainbow Trout) in Louisiana SO SOUTHEASTERN NATURALIST LA English DT Article AB An individual of Oncothynchus mykiss (Rainbow Trout) was collected in a diversion canal of the Mississippi River known as Davis Pond located at river kilometer (RKM) 191.03 in St. Charles Parish near Luling, LA. This locality is the southern-most record for Rainbow Trout in the Mississippi River Basin and represents a range extension of 733.5 RKM south from the previous southern-most locality at Lake Whittington, Bolivar County, MS. The collection we report here also represents the first documented record of Rainbow Trout in Louisiana. C1 [George, Steven G.; Slack, William T.; Killgore, K. Jack] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP George, SG (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Steven.G.George@usace.army.mil OI Killgore, William/0000-0002-5328-0208 FU US Army Corps of Engineers, New Orleans District FX This project was funded by the US Army Corps of Engineers, New Orleans District. Field assistance was provided by J.J. Hoover, W.E. Lancaster, J.P. Kirk, C. Murphy, J.A. Collins, B.R. Lewis. and C. Troxler. Permission to publish was provided by the Chief of Engineers. NR 15 TC 0 Z9 0 U1 0 U2 3 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PD JUN PY 2013 VL 12 IS 2 BP 448 EP 450 DI 10.1656/058.012.0217 PG 3 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 217RR UT WOS:000324378200016 ER PT J AU Propper, RE Januszewski, A Brunye, TT Christman, SD AF Propper, Ruth E. Januszewski, Ashley Brunye, Tad T. Christman, Stephen D. TI Tympanic Membrane Temperature, Hemispheric Activity, and Affect: Evidence for a Modest Relationship SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID VISUAL-FIELD STIMULATION; ACTIVATION; HANDEDNESS; ASYMMETRY AB Tympanic membrane temperature (TMT) offers a methodologically simple and noninvasive means to provide a physiological measure of hemispheric activation, although the mechanisms by which it may be related to hemispheric activity are not completely known. Here, the authors examined TMT at baseline and after a mood-induction protocol. They replicate baseline associations between increased absolute difference between left and right TMT and increased anger, and found evidence for a link between increased TMT and increased ipsilateral hemispheric activation after mood-induction. They also found tentative evidence for the existence of right-lateralized emotional hyperthermia after mood-induction. C1 [Propper, Ruth E.] Montclair State Univ, Dept Psychol, Montclair, NJ USA. [Januszewski, Ashley] Merrimack Coll, Dept Psychol, N Andover, MA 01845 USA. [Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. [Christman, Stephen D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, Montclair, NJ USA. EM propperr@mail.montclair.edu FU U.S. Army [W911QY-09-P-0567, W911QY-10-P-0420] FX This work was supported by U.S. Army Contracts #W911QY-09-P-0567 and W911QY-10-P-0420. The opinions expressed herein are those of the authors and not necessarily of the U.S. Army. NR 17 TC 0 Z9 0 U1 0 U2 5 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD SUM PY 2013 VL 25 IS 3 BP 198 EP 204 PG 7 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 215XC UT WOS:000324243300037 PM 23695535 ER PT J AU Hall, LD Dalton, SR Fillman, EP Dohse, L Elston, DM AF Hall, Lawrence D. Dalton, Scott R. Fillman, Eric P. Dohse, Lindsay Elston, Dirk M. TI Re-examination of Features to Distinguish Polyarteritis Nodosa From Superficial Thrombophlebitis SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE polyarteritis nodosa; superficial thrombophlebitis; internal elastic lamina; smooth muscle pattern; elastic fiber pattern; misdiagnosis ID INTERNAL ELASTIC LAMINA; VARICOSE-VEINS; FIBERS; ARTERY AB The correct identification of vessel type is crucial in distinguishing cutaneous polyarteritis nodosa from superficial thrombophlebitis. As the treatment and prognosis of these conditions are very different, correct diagnosis is critical, but they have overlapping clinical and histopathologic features, which can sometimes make the distinction difficult. Features commonly used to distinguish an artery from vein include vessel shape and diameter, the presence or absence of an internal elastic lamina, smooth muscle pattern, and the presence or absence of valves. Recently, it has been proposed that the amount and distribution of elastic fibers in the medial muscular layer are the most reliable features to make this distinction. The first part of this study used prosector-identified vessels to determine which of these features is most sensitive and specific for identifying an artery and vein. A total of 19 arteries and 16 veins were dissected from autopsy and amputation specimens. For each specimen, the smooth muscle pattern, elastic fiber pattern, the presence of valves, and the presence or absence of an internal elastic membrane were determined. The quantity of elastic fibers in the muscular wall of each sample was also determined. Although the elastic fiber pattern was the most specific feature in identifying a vein, it suffered from low sensitivity (43.8%). The smooth muscle pattern had the highest combined sensitivity and specificity. In the second part of this study, the histologic features listed above were examined in previously diagnosed cases of superficial thrombophlebitis and arteritis. When inflammation is present within and around the wall of the vessel, all of the studied histologic features become less reliable, and the interobserver reliability of distinguishing arteritis from thrombophlebitis was low. Our findings suggest that no single histopathologic feature is completely reliable and combining the histopathologic features with clinicopathologic correlation is essential for correct vessel identification. C1 [Hall, Lawrence D.; Dalton, Scott R.; Dohse, Lindsay] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. [Fillman, Eric P.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Elston, Dirk M.] Ackerman Acad Dermatopathol, New York, NY USA. RP Hall, LD (reprint author), Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. EM ldhall@geisinger.edu NR 13 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD JUN PY 2013 VL 35 IS 4 BP 463 EP 471 DI 10.1097/DAD.0b013e3182770a42 PG 9 WC Dermatology SC Dermatology GA 150JK UT WOS:000319386300016 PM 23392132 ER PT J AU Torrieri, D Valenti, MC AF Torrieri, Don Valenti, Matthew C. TI Exclusion and Guard Zones in DS-CDMA Ad Hoc Networks SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Spread-spectrum communication; carrier-sense multiaccess; mobile communications; fading channels ID WIRELESS NETWORKS; TRANSMISSION CAPACITY; INTERFERENCE AB The central issue in direct-sequence code-division multiple-access (DS-CDMA) ad hoc networks is the prevention of a near-far problem. This paper considers two types of guard zones that may be used to control the near-far problem: a fundamental exclusion zone and an additional CSMA guard zone that may be established by the carrier-sense multiple-access (CSMA) protocol. In the exclusion zone, no mobiles are physically present, modeling the minimum physical separation among mobiles that is always present in actual networks. Potentially interfering mobiles beyond a transmitting mobile's exclusion zone, but within its CSMA guard zone, are deactivated by the protocol. This paper provides an analysis of DS-CSMA networks with either or both types of guard zones. A network of finite extent with a finite number of mobiles and uniform clustering as the spatial distribution is modeled. The analysis applies a closed-form expression for the outage probability in the presence of Nakagami fading, conditioned on the network geometry. The tradeoffs between exclusion zones and CSMA guard zones are explored for DS-CDMA and unspread networks. The spreading factor and the guard-zone radius provide design flexibility in achieving specified levels of average outage probability and transmission capacity. The advantage of an exclusion zone over a CSMA guard zone is that since the network is not thinned, the number of active mobiles remains constant, and higher transmission capacities can be achieved. C1 [Torrieri, Don] US Army Res Lab, Adelphi, MD USA. [Valenti, Matthew C.] W Virginia Univ, Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), US Army Res Lab, Adelphi, MD USA. EM don.j.torrieri.civ@mail.mil; valenti@ieee.org OI Valenti, Matthew/0000-0001-6089-0509 FU National Science Foundation [CNS-0750821]; United States Army Research Laboratory [W911NF-10-0109] FX M. C. Valenti's contribution was sponsored by the National Science Foundation under Award No. CNS-0750821, and by the United States Army Research Laboratory under Contract W911NF-10-0109. NR 16 TC 9 Z9 9 U1 2 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD JUN PY 2013 VL 61 IS 6 BP 2468 EP 2476 DI 10.1109/TCOMM.2013.041113.120714 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 175GO UT WOS:000321219100033 ER PT J AU Mersel, MK Smith, LC Andreadis, KM Durand, MT AF Mersel, Matthew K. Smith, Laurence C. Andreadis, Konstantinos M. Durand, Michael T. TI Estimation of river depth from remotely sensed hydraulic relationships SO WATER RESOURCES RESEARCH LA English DT Article DE hydraulic geometry; river depth; surface water and ocean topography; SWO; slope break ID SATELLITE RADAR ALTIMETRY; SYNTHETIC-APERTURE RADAR; WATER-LEVEL CHANGES; AMAZON FLOODPLAIN; WETLAND DYNAMICS; INUNDATION AREA; SURFACE-WATER; GEOMETRY; DISCHARGE; BASIN AB The Surface Water and Ocean Topography (SWOT) radar interferometer satellite mission will provide unprecedented global measurements of water surface elevation (h) for inland water bodies. However, like most remote sensing technologies SWOT will not observe river channel bathymetry below the lowest observed water surface, thus limiting its value for estimating river depth and/or discharge. This study explores if remotely sensed observations of river inundation width and h alone, when accumulated over time, may be used to estimate this unmeasurable flow depth. To test this possibility, synthetic values of h and either cross-sectional flow width (w) or effectivewidth (We, inundation area divided by reach length) are extracted from 1495 previously surveyed channel cross-sections for the Upper Mississippi, Illinois, Rio Grande, and Ganges-Brahmaputra river systems, and from 62 km of continuously acquired sonar data for the Upper Mississippi. Two proposed methods (called "Linear" and "Slope-Break") are tested that seek to identify a small subset of geomorphically "optimal" locations where w or We covary strongly with h, such that they may be usefully extrapolated to estimate mean cross-sectional flow depth (d). While the simplest Linear Method is found to have considerable uncertainty, the Slope-Break Method, identifying locations where two distinct hydraulic relationships are identified (one for moderate to high flows and one for low flows), holds promise. Useful slope breaks were discovered in all four river systems, ranging from 6 (0.04%) to 242 (16%) of the 1495 studied cross-sections, assuming channel bathymetric exposures ranging from 20% to 95% of bankfull conditions, respectively. For all four rivers, the derived depth estimates from the Slope-Break Method have root mean squared errors (RMSEs) of <20% (relative to bankfull mean depth) assuming at least one channel bathymetry exposure of similar to 25% or greater. Based on historic discharge records and HEC-RAS hydraulic modeling, the Upper Mississippi and Rio Grande rivers experience adequate channel exposures at least similar to 60% and similar to 42% of the time, respectively. For the Upper Mississippi, so-called "reach-averaging" (spatial averaging along some predetermined river length) of native-resolution h and We values reduces both RMSE and longitudinal variability in the derived depth estimates, especially at reach-averaging lengths of similar to 1000-2000 m. These findings have positive implications for SWOT and other sensors attempting to estimate river flow depth and/or discharge solely from incomplete, remotely sensed hydraulic variables, and suggest that useful depth retrievals can be obtained within the spatial and temporal constraints of satellite observations. C1 [Mersel, Matthew K.; Smith, Laurence C.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90024 USA. [Smith, Laurence C.] Univ Calif Los Angeles, Dept Earth & Space Sci, Los Angeles, CA 90024 USA. [Andreadis, Konstantinos M.] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA. [Durand, Michael T.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA. [Durand, Michael T.] Ohio State Univ, Byrd Polar Res Ctr, Columbus, OH 43210 USA. RP Mersel, MK (reprint author), Cold Reg Res & Engn Lab, RS GIS 103,72 Lyme Rd, Hanover, NH 03755 USA. EM mmersel@ucla.edu RI Durand, Michael/D-2885-2013; Smith, Laurence/E-7785-2012 OI Smith, Laurence/0000-0001-6866-5904 FU NASA Physical Oceanography Program [NNX10AE96G] FX This research was funded by the NASA Physical Oceanography Program (grant NNX10AE96G), managed by Eric Lindstrom. In situ cross-section data for the Ganges-Brahmaputra river system was provided by Faissal Hossain (Tennessee Technical University) as part of a Memorandum of Understanding between the Institute of Water Modeling-Bangladesh and Tennessee Technical University. In situ cross-section data for the Rio Grande (surveyed by Tetra Tech Inc.) and for the Upper Mississippi and Illinois rivers (surveyed by the U. S. Army Corps of Engineers) was provided to the authors by Edward Beighley (FM Global). The continuous in situ bathymetric data set for the Upper Mississippi was provided by the USGS, as part of the Long Term Resource Monitoring Program. The authors thank Doug Alsdorf, Paul Bates, and one anonymous reviewer for their constructive feedback on this paper. NR 51 TC 19 Z9 19 U1 3 U2 49 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD JUN PY 2013 VL 49 IS 6 BP 3165 EP 3179 DI 10.1002/wrcr.20176 PG 15 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 189BF UT WOS:000322241300007 ER PT J AU Hung, BWK Kolitz, SE Ozdaglar, A AF Hung, Benjamin W. K. Kolitz, Stephan E. Ozdaglar, Asuman TI Optimization-Based Influencing of Village Social Networks in a Counterinsurgency SO ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY LA English DT Article DE Human Factors; Economics; Social network; agent modeling; network optimization; opinion dynamics; counterinsurgency AB This article considers the nonlethal targeting assignment problem in the counterinsurgency in Afghanistan, the problem of deciding on the people whom U.S. forces should engage through outreach, negotiations, meetings, and other interactions in order to ultimately win the support of the population in their area of operations. We propose two models: (1) the Afghan counterinsurgency (COIN) social influence model, to represent how attitudes of local leaders are affected by repeated interactions with other local leaders, insurgents, and counterinsurgents, and (2) the nonlethal targeting model, a NonLinear Programming (NLP) optimization formulation that identifies a strategy for assigning k U.S. agents to produce the greatest arithmetic mean of the expected long-term attitude of the population. We demonstrate in an experiment the merits of the optimization model in nonlethal targeting, which performs significantly better than both doctrine-based and random methods of assignment in a large network. C1 [Hung, Benjamin W. K.] USMA, Dept Math Sci, West Point, NY 10996 USA. [Kolitz, Stephan E.] Charles Stark Draper Lab, Cambridge, MA USA. [Ozdaglar, Asuman] MIT, Cambridge, MA 02139 USA. RP Hung, BWK (reprint author), USMA, Dept Math Sci, 601 Thayer Rd, West Point, NY 10996 USA. EM benjamin.w.hung@us.army.mil FU Omar N. Bradley Foundation FX This research was supported by the Omar N. Bradley Foundation and Fellowship. NR 22 TC 0 Z9 0 U1 0 U2 3 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 2157-6904 J9 ACM T INTEL SYST TEC JI ACM Trans. Intell. Syst. Technol. PD JUN PY 2013 VL 4 IS 3 AR UNSP 52 DI 10.1145/2483669.2483685 PG 22 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA 175IH UT WOS:000321223600016 ER PT J AU Walker, W AF Walker, Wickliffe TI A Border Incident SO FIDDLEHEAD LA English DT Fiction, Creative Prose C1 [Walker, Wickliffe] US Army, Adelphi, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEW BRUNSWICK PI FREDERICTON PA DEPT ENGLISH, CAMPUS HOUSE, PO BOX 4400, FREDERICTON, NB E3B 5A3, CANADA SN 0015-0630 J9 FIDDLEHEAD JI Fiddlehead PD SUM PY 2013 IS 256 BP 114 EP 125 PG 12 WC Literary Reviews SC Literature GA 191SA UT WOS:000322431700014 ER PT J AU Aram, S Singh, R Dinavahi, SPG AF Aram, Shawn Singh, Rajneesh Dinavahi, Surya P. G. TI CFD Analysis of Flapping Wings in Ultra-Low Reynolds Number Regime SO INTERNATIONAL JOURNAL OF MICRO AIR VEHICLES LA English DT Article AB Computational simulations are conducted to investigate the fluid dynamics of flapping wings at ultra-low Reynolds numbers for micro-aerial vehicle applications. Rigid solid wing and 'comb'-like of the same planform and the equal thicknesses are considered in the current study. Incompressible flow simulations are carried out to compute flowfield and aerodynamic forces on the wings for two types of wing kinematic motions. A parametric study of geometric and kinematic parameters is also conducted to compare the two wings. The aerodynamic forces for Solid wing and the Comb wing are found to be quite similar at lower Reynolds number however the detailed examination of the forces showed that the force generation mechanisms on the two wings are quite different. Analysis suggests that the Comb wings can provide a significant weight savings with a minimal loss in the aerodynamic performance for ultra-low Reynolds number applications. C1 [Aram, Shawn] ORAU, Aberdeen Proving Ground, MD 21005 USA. [Singh, Rajneesh] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Dinavahi, Surya P. G.] Lockheed Martin Co, Aberdeen Proving Ground, MD 21005 USA. RP Aram, S (reprint author), ORAU, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 0 Z9 0 U1 0 U2 9 PU MULTI-SCIENCE PUBL CO LTD PI BRENTWOOD PA 5 WATES WAY, BRENTWOOD CM15 9TB, ESSEX, ENGLAND SN 1756-8293 J9 INT J MICRO AIR VEH JI Int. J. Micro Air Veh. PD JUN PY 2013 VL 5 IS 2 BP 93 EP 107 DI 10.1260/1756-8293.5.2.93 PG 15 WC Engineering, Aerospace SC Engineering GA 190CM UT WOS:000322315200001 ER PT J AU Kane, JR Ayers, P Howard, H Anderson, A Koch, D AF Kane, James R. Ayers, Paul Howard, Heidi Anderson, Alan Koch, Daniel TI Multipass coefficients for terrain impacts based on military vehicle type, size and dynamic operating properties SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Multipass; Tracked; Wheeled; Military lands; Predictive modeling AB Quantification of multipass vehicle impacts is needed to determine terrain disturbance during military training. This study, conducted at Fort Riley, Kansas on a clay loam soil, evaluated the multipass terrain impacts of four military vehicles: the M1A1 Main Battle Tank, M998 HMMWV, M985 HEMTT, and M113 APC. Disturbed width and impact severity were assessed along 14 spirals subjected to a maximum of eight passes for a total of 696 impact points. Project goals included evaluating vegetation impacts by tracked and wheeled military vehicles across multiple passes in order to develop coefficients allowing more accurate predictive modeling of vehicle multipass impacts. Multiple passes produce increased vegetative impacts, with multipass coefficients (MPC) ranging from 0.98 to 4.44 depending on vehicle type, size and turn severity. Tracked vehicles were found to have a higher multipass coefficient than wheeled vehicles, with multipass coefficients increasing with vehicle weight and the sharpness of turns. The components of a more theoretical and universal multipass vehicle impact model are discussed. Understanding multipass dynamics will allow land managers to determine the extent and severity of terrain impacts on military training areas and quickly evaluate vehicle environmental impacts when used in conjunction with a GPS-based vehicle tracking system (VTS). (C) 2013 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Kane, James R.; Ayers, Paul] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Howard, Heidi; Anderson, Alan; Koch, Daniel] US Army Corps Engineers, Erdc, CERL, Construct Engn Res Lab,Engineers Engineer Res & D, Champaign, IL 61826 USA. RP Kane, JR (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr,Ste 314, Knoxville, TN 37996 USA. EM jkane745@yahoo.com; pdayers@utk.edu; heidi.r.howard@usace.army.mil; alan.b.anderson@usace.army.mil; daniel.j.koch@usace.army.mil FU Environmental Security Technology Certification Program (ESTCP) FX We acknowledge the Environmental Security Technology Certification Program (ESTCP) for providing financial support for this study. We also acknowledge and thank installation staff at Fort Riley for assisting with coordination and data collection. NR 16 TC 2 Z9 2 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD JUN PY 2013 VL 50 IS 3 BP 175 EP 183 DI 10.1016/j.jterra.2013.04.001 PG 9 WC Engineering, Environmental SC Engineering GA 190RR UT WOS:000322358400003 ER PT J AU Snider, KF Halpern, BH Rendon, RG Kidalov, MV AF Snider, Keith F. Halpern, Barton H. Rendon, Rene G. Kidalov, Max V. TI Corporate social responsibility and public procurement: How supplying government affects managerial orientations SO JOURNAL OF PURCHASING AND SUPPLY MANAGEMENT LA English DT Article DE Corporate social responsibility; Public procurement; Government purchasing; Contracting ID STAKEHOLDER THEORY; COMPETITIVE ADVANTAGE; INSTITUTIONAL THEORY; CHAIN MANAGEMENT; UNITED-STATES; PERFORMANCE; BUSINESS; IMPLICIT; INDUSTRY; DRIVERS AB How does government drive the corporate social responsibility of firms that supply it with goods and services? This paper reviews relevant theory and practice to describe ways in which public procurement shapes corporate social responsibility, and it builds upon theory to develop testable propositions to describe these influences. Using the case of U.S. defense procurement, statistical analysis indicates a significant relationship between the extent to which firms engage in defense procurement and the corporate social responsibility orientations of their managers. The findings have application both for social responsibility theory and for public procurement policy and practice. Published by Elsevier Ltd. C1 [Snider, Keith F.; Rendon, Rene G.; Kidalov, Max V.] USN, Postgrad Sch, Grad Sch Business & Publ Policy, Monterey, CA 93943 USA. [Halpern, Barton H.] USA, Attn RDAR EIJ, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Snider, KF (reprint author), USN, Postgrad Sch, Grad Sch Business & Publ Policy, 555 Dyer Rd, Monterey, CA 93943 USA. EM ksnider@nps.edu NR 85 TC 6 Z9 6 U1 2 U2 33 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1478-4092 J9 J PURCH SUPPLY MANAG JI J. Purch. Supply Manag. PD JUN PY 2013 VL 19 IS 2 BP 63 EP 72 DI 10.1016/j.pursup.2013.01.001 PG 10 WC Management SC Business & Economics GA 185AE UT WOS:000321936800003 ER PT J AU Choi, YS Berry-Caban, C Nance, J AF Choi, Y. Sammy Berry-Caban, Cristobal Nance, Julie TI Telemedicine in paediatric patients with poorly controlled type 1 diabetes SO JOURNAL OF TELEMEDICINE AND TELECARE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; GLYCEMIC CONTROL; SUPPORT; ADOLESCENTS; MANAGEMENT; CHILDREN; SYSTEM; TIME; CARE AB We conducted a retrospective study of a telemedicine clinic for paediatric patients with poorly controlled type 1 diabetes. Thirty-one patients (mean age 12 years) were enrolled into the clinic. After an initial visit, a group messaging system was provided to allow communication with the diabetic team which consisted of a diabetic provider, diabetic educator, insulin pump trainer and dietician. Patients and parents were encouraged to make all contacts by electronic means. For urgent matters, direct paging access was provided to the diabetic team. Adjustments in insulin dosing were accomplished via automated web-based communication or email between patient and provider. Compared to baseline, the HbA(1c) levels were significantly lower at 3 months (9.1% vs. 11.1%, P < 0.05) and 6.5 months (9.5% vs. 11.1%, P < 0.05). There were no significant differences in HbA(1c) levels for different age categories, insulin delivery methods or number of telemedicine encounters. The study showed that while telemedicine was effective in lowering HbA1c levels, it did not achieve optimum control. C1 [Choi, Y. Sammy] Dept Med, Ft Bragg, NC 28310 USA. [Choi, Y. Sammy] Dept Pediat, Ft Bragg, NC 28310 USA. [Berry-Caban, Cristobal] Clin Invest Serv, Ft Bragg, NC USA. [Nance, Julie] Sentara Careplex Hosp, Diabet Educ Program, Hampton, VA USA. RP Choi, YS (reprint author), Dept Med, Ft Bragg, NC 28310 USA. EM young.choi@amedd.army.mil NR 17 TC 2 Z9 2 U1 2 U2 9 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 1357-633X J9 J TELEMED TELECARE JI J. Telemed. Telecare PD JUN PY 2013 VL 19 IS 4 BP 219 EP 221 DI 10.1258/jtt.2012.120506 PG 3 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 185EZ UT WOS:000321949700008 PM 23401606 ER PT J AU Dawson, C Trahan, CJ Kubatko, EJ Westerink, JJ AF Dawson, Clint Trahan, Corey Jason Kubatko, Ethan J. Westerink, Joannes J. TI A parallel local timestepping Runge-Kutta discontinuous Galerkin method with applications to coastal ocean modeling SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article DE Local timestepping; Multirate methods; Shallow water equations; Runge-Kutta discontinuous Galerkin methods; Tidal flows; Hurricane storm surge ID SHALLOW-WATER EQUATIONS; CONSERVATION-LAWS; VARYING TIME; SCHEMES; INTEGRATION; REFINEMENT AB Geophysical flows over complex domains often encompass both coarse and highly resolved regions. Approximating these flows using shock-capturing methods with explicit timestepping gives rise to a Courant-Friedrichs-Lewy (CFL) timestep constraint. This approach can result in small global timesteps often dictated by flows in small regions, vastly increasing computational effort over the whole domain. One approach for coping with this problem is to use locally varying timesteps. In previous work, we formulated a local timestepping (LTS) method within a Runge-Kutta discontinuous Galerkin framework and demonstrated the accuracy and efficiency of this method on serial machines for relatively small-scale shallow water applications. For more realistic models involving large domains and highly complex physics, the LTS method must be parallelized for multi-core parallel computers. Furthermore, additional physics such as strong wind forcing can effect the choice of local timesteps. In this paper, we describe a parallel LTS method, parallelized using domain decomposition and MPI. We demonstrate the method on tidal flows and hurricane storm surge applications in the coastal regions of the Western North Atlantic Ocean. (C) 2013 Elsevier B.V. All rights reserved. C1 [Dawson, Clint] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Trahan, Corey Jason] Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kubatko, Ethan J.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. [Westerink, Joannes J.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. RP Dawson, C (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. EM clint@ices.utexas.edu; ctrahan@drc.com; kubatko.3@osu.edu; jjw@nd.edu FU National Science Foundation [DMS-1217071, DMS-0915223, OCI-0746232, DMS-0915118, DMS-1217218] FX Author C. Dawson acknowledges the support of National Science Foundation Grants DMS-1217071 and DMS-0915223. J. Westerink acknowledges the support of National Science Foundation Grant OCI-0746232, and E. Kubatko acknowledges National Science Foundation Grants DMS-0915118 and DMS-1217218. NR 35 TC 9 Z9 9 U1 0 U2 12 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 EI 1879-2138 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD JUN 1 PY 2013 VL 259 BP 154 EP 165 DI 10.1016/j.cma.2013.03.015 PG 12 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA 170GH UT WOS:000320837900012 ER PT J AU Stratman, K Overholt, WA Cuda, JP Netherland, MD Wilson, PC AF Stratman, K. Overholt, W. A. Cuda, J. P. Netherland, M. D. Wilson, P. C. TI THE DIVERSITY OF CHIRONOMIDAE ASSOCIATED WITH HYDRILLA IN FLORIDA, WITH SPECIAL REFERENCE TO CRICOTOPUS LEBETIS (DIPTERA: CHIRONOMIDAE) SO FLORIDA ENTOMOLOGIST LA English DT Editorial Material DE abundance; biological control; distribution; herbivores; Shannon Index; species richness ID LARVAL CHIRONOMIDAE; VERTICILLATA AB The chironomid community associated with hydrilla tips in Florida was diverse, including 16 species of herbivores, detritivores and predators. Cricotopus lebetis, an herbivore of hydrilla, was found in 3 of 6 sampled water bodies, but its abundance, and that of the other midge species, was low. C1 [Stratman, K.; Overholt, W. A.; Wilson, P. C.] Univ Florida, Biol Control Res & Containment Lab, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA. [Cuda, J. P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Netherland, M. D.] United States Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Overholt, WA (reprint author), Univ Florida, Biol Control Res & Containment Lab, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA. EM billover@ufl.edu NR 19 TC 4 Z9 4 U1 1 U2 9 PU FLORIDA ENTOMOLOGICAL SOC PI LUTZ PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA SN 0015-4040 J9 FLA ENTOMOL JI Fla. Entomol. PD JUN PY 2013 VL 96 IS 2 BP 654 EP 657 PG 4 WC Entomology SC Entomology GA 168VY UT WOS:000320737200049 ER PT J AU Grzegorczyk, TM Barrowes, BE AF Grzegorczyk, Tomasz M. Barrowes, Benjamin E. TI Real-Time Processing of Electromagnetic Induction Dynamic Data Using Kalman Filters for Unexploded Ordnance Detection SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Electromagnetic induction (EMI); Kalman filters (KFs); MetalMapper sensor; second-version Man Portable Vector (MPV-II) sensor; real-time systems; unexploded ordnance (UXO) ID UXO DISCRIMINATION; COMPONENT ANALYSIS; CLASSIFICATION; SENSOR; IDENTIFICATION; UNCERTAINTY; OBJECTS; MODEL AB The current procedure to detect and identify unexploded ordnance (UXO) using electromagnetic induction (EMI) time-domain sensors is based on two steps. First, data are acquired over large areas in dynamic mode, and locations of interest are flagged based on measured field amplitudes. Second, sensors return to the flagged areas for more in-depth cued interrogation, providing high-quality data for subsequent identification and classification. Flagging based on field amplitude, however, has potential drawbacks: The magnetic field in the EMI regime exhibits a 1/R-6 drop-off with range, and a deep UXO may not produce a strong response while still being potentially hazardous. To address this problem, we propose in this paper an inversion method based on Kalman and extended Kalman filters meant to do the following: 1) work with dynamic data; 2) provide both position and polarizability estimates; and 3) operate in real time (less than 100 ms in our case). Such full characterization of the target, albeit limited to within the 2.7-ms interrogation time window of the dynamic mode associated with the sensors studied here, provides useful information when deciding whether to continue with the cued interrogation. We validate the method for two popular EMI sensors, the second-version Man Portable Vector (MPV-II) and the MetalMapper, operated in very different settings: The MPV-II is used to interrogate a limited region of space atop a single target, whereas the MetalMapper is driven over long lanes along which several targets and clutter items are present. C1 [Grzegorczyk, Tomasz M.] Delpsi LLC, Newton, MA 02458 USA. [Barrowes, Benjamin E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Grzegorczyk, TM (reprint author), Delpsi LLC, Newton, MA 02458 USA. EM tomasz.grzegorczyk@delpsi.com; Benjamin.E.Barrowes@usace.army.mil FU Strategic Environmental Research and Development Program [W912HQ-11-C-0072] FX This work was supported by the Strategic Environmental Research and Development Program under Contract W912HQ-11-C-0072. NR 40 TC 2 Z9 2 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUN PY 2013 VL 51 IS 6 BP 3439 EP 3451 DI 10.1109/TGRS.2012.2222032 PN 1 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 171PE UT WOS:000320940600020 ER PT J AU Rosati, JD Dean, RG Walton, TL AF Rosati, J. D. Dean, R. G. Walton, T. L. TI The modified Bruun Rule extended for landward transport SO MARINE GEOLOGY LA English DT Article DE shoreline retreat; sea level rise; overwash; equilibrium beach profile ID SEA-LEVEL RISE; COASTAL EROSION; BARRIER ISLANDS; BEACH EROSION; OVERWASH; MODEL; STORMS; SCALE AB The Bruun Rule (Bruun, 1954, 1962) provides a relationship between sea level rise and shoreline retreat, and has been widely applied by the engineering and scientific communities to interpret shoreline changes and to plan for possible future increases in sea level rise rates. The Bruun Rule assumes that all sand removed from the upper profile is deposited offshore as sea level rises, although overwash during storms and landward Aeolian transport clearly indicate otherwise. Herein, we examine processes associated with sandy beach evolution in response to relative sea level rise and propose a modified form of the Bruun Rule that considers the full range of parsing cross-shore transport, from completely seaward to completely landward depending on the prevailing storm and surge conditions and whether there is a surplus or deficit of sand in the profile with respect to the equilibrium beach profile. A methodology is proposed that more appropriately represents the long-term processes and beach response. However, an improved quantitative understanding of landward transport is required for optimal application of the proposed method. Published by Elsevier B.V. C1 [Rosati, J. D.] US Army Corps Engineers, Washington, DC 20314 USA. [Dean, R. G.] Univ Florida, Gainesville, FL 32605 USA. [Walton, T. L.] Coastal Tech Corp, Tallahassee, FL USA. RP Rosati, JD (reprint author), US Army Corps Engineers, Washington, DC 20314 USA. EM Julie.D.Rosati@usace.army.mil FU USACE's Coastal Inlets Research Program (CIRP) FX We appreciate suggestions and comments from Mr. Mark Gravens, U.S. Army Corps of Engineers (USACE), Dr. James Houston, Retired Emeritus, USACE, two anonymous reviewers and the Editor, who greatly improved the clarity of the manuscript. This work was conducted with partial funding (JDR) from the USACE's Coastal Inlets Research Program (CIRP). NR 62 TC 13 Z9 13 U1 1 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD JUN 1 PY 2013 VL 340 BP 71 EP 81 DI 10.1016/j.margeo.2013.04.018 PG 11 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 180OF UT WOS:000321603800006 ER PT J AU Yang, Y Callahan, JM Kim, TH Brown, AS Everitt, HO AF Yang, Yang Callahan, John M. Kim, Tong-Ho Brown, April S. Everitt, Henry O. TI Ultraviolet Nanoplasmonics: A Demonstration of Surface-Enhanced Raman Spectroscopy, Fluorescence, and Photodegradation Using Gallium Nanoparticles SO NANO LETTERS LA English DT Article DE Ultraviolet; plasmonics; gallium; nanoparticles; surface-enhanced Raman; surface-enhanced fluorescence ID SINGLE-MOLECULE DETECTION; UV RESONANCE RAMAN; METAL NANOPARTICLES; CRYSTAL-VIOLET; ALUMINUM NANOPARTICLES; SCATTERING SERS; EXCITATION; PHOTOLUMINESCENCE; ELLIPSOMETRY; DYNAMICS AB Self-assembled arrays of hemispherical gallium nanoparticles deposited by molecular beam epitaxy on a sapphire support are explored as a new type of substrate for ultraviolet plasmonics. Spin-casting a 5 nm film of crystal violet upon these nanoparticles permitted the demonstration of surface-enhanced Raman spectra, fluorescence, and degradation following excitation by a HeCd laser operating at 325 nm. Measured local Raman enhancement factors exceeding 10(7) demonstrate the potential of gallium nanoparticle arrays for plasmonically enhanced ultraviolet detection and remediation. C1 [Yang, Yang; Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Callahan, John M.] AEgis Technol Grp Inc, Huntsville, AL 35806 USA. [Kim, Tong-Ho; Brown, April S.; Everitt, Henry O.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. RP Everitt, HO (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU Army Aviation & Missile Research, Development, and Engineering Center; Office of Naval Research FX This work was supported by the Army Aviation & Missile Research, Development, and Engineering Center and the Office of Naval Research. The authors thank the early contributions of Ga NP SERS, spin-casting of CV, and building the spectrometer by P. C. Wu, K. R. Lantz, and J. V. Foreman, respectively. The authors would like to thank Greg Sun, Dana Dlott, Maria Losurdo, George Schatz, Fernando Moreno, Francisco Gonzalez, Pablo Albella, and Juan Marcos Sanz Casado for their insightful comments. NR 56 TC 31 Z9 31 U1 7 U2 136 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD JUN PY 2013 VL 13 IS 6 BP 2837 EP 2841 DI 10.1021/nl401145j PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 165LJ UT WOS:000320485100085 PM 23659187 ER PT J AU West, D West, BJ AF West, Damien West, Bruce J. TI Physiologic time: A hypothesis SO PHYSICS OF LIFE REVIEWS LA English DT Review ID UNIVERSAL METABOLIC ALLOMETRY; IRREVERSIBLE-PROCESSES; SCALING LAWS; STATISTICAL ARTIFACT; RECIPROCAL RELATIONS; ENERGY-METABOLISM; ONTOGENIC GROWTH; COMPLEX NETWORKS; ENQUIST MODEL; GENERAL-MODEL AB The scaling of respiratory metabolism with body size in animals is considered by many to be a fundamental law of nature. One apparent consequence of this law is the scaling of physiologic time with body size, implying that physiologic time is separate and distinct from clock time. Physiologic time is manifest in allometry relations for lifespans, cardiac cycles, blood volume circulation, respiratory cycle, along with a number of other physiologic phenomena. Herein we present a theory of physiologic time that explains the allometry relation between time and total body mass averages as entailed by the hypothesis that the fluctuations in the total body mass are described by a scaling probability density. Published by Elsevier B.V. C1 [West, Damien] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. [West, Bruce J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC USA. RP West, BJ (reprint author), US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC USA. EM bruce.j.west.civ@mail.mil RI West, Damien/F-8616-2012; West, Bruce/E-3944-2017 OI West, Damien/0000-0002-4970-3968; NR 94 TC 20 Z9 20 U1 0 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1571-0645 EI 1873-1457 J9 PHYS LIFE REV JI Phys. Life Rev. PD JUN PY 2013 VL 10 IS 2 BP 210 EP 224 DI 10.1016/j.plrev.2013.04.006 PG 15 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 179QZ UT WOS:000321537700019 PM 23659904 ER PT J AU Peterson, TC Heim, RR Hirsch, R Kaiser, DP Brooks, H Diffenbaugh, NS Dole, RM Giovannettone, JP Guirguis, K Karl, TR Katz, RW Kunkel, K Lettenmaier, D McCabe, GJ Paciorek, CJ Ryberg, KR Schubert, S Silva, VBS Stewart, BC Vecchia, AV Villarini, G Vose, RS Walsh, J Wehner, M Wolock, D Wolter, K Woodhouse, CA Wuebbles, D AF Peterson, Thomas C. Heim, Richard R., Jr. Hirsch, Robert Kaiser, Dale P. Brooks, Harold Diffenbaugh, Noah S. Dole, Randall M. Giovannettone, Jason P. Guirguis, Kristen Karl, Thomas R. Katz, Richard W. Kunkel, Kenneth Lettenmaier, Dennis McCabe, Gregory J. Paciorek, Christopher J. Ryberg, Karen R. Schubert, Siegfried Silva, Viviane B. S. Stewart, Brooke C. Vecchia, Aldo V. Villarini, Gabriele Vose, Russell S. Walsh, John Wehner, Michael Wolock, David Wolter, Klaus Woodhouse, Connie A. Wuebbles, Donald TI MONITORING AND UNDERSTANDING CHANGES IN HEAT WAVES, COLD WAVES, FLOODS, AND DROUGHTS IN THE UNITED STATES: State of Knowledge SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID SOUTHWESTERN NORTH-AMERICA; SOIL-MOISTURE; CLIMATE-CHANGE; WATER MANAGEMENT; GREAT-PLAINS; NEW-ENGLAND; DUST-BOWL; US; TEMPERATURE; STREAMFLOW AB Weather and climate extremes have been varying and changing on many different time scales. In recent decades, heat waves have generally become more frequent across the United States, while cold waves have been decreasing. While this is in keeping with expectations in a warming climate, it turns out that decadal variations in the number of U.S. heat and cold waves do not correlate well with the observed U.S. warming during the last century. Annual peak flow data reveal that river flooding trends on the century scale do not show uniform changes across the country. While flood magnitudes in the Southwest have been decreasing, flood magnitudes in the Northeast and north-central United States have been increasing. Confounding the analysis of trends in river flooding is multiyear and even multidecadal variability likely caused by both large-scale atmospheric circulation changes and basin-scale memory in the form of soil moisture. Droughts also have long-term trends as well as multiyear and decadal variability. Instrumental data indicate that the Dust Bowl of the 1930s and the drought in the 1950s were the most significant twentieth-century droughts in the United States, while tree ring data indicate that the megadroughts over the twelfth century exceeded anything in the twentieth century in both spatial extent and duration. The state of knowledge of the factors that cause heat waves, cold waves, floods, and drought to change is fairly good with heat waves being the best understood. C1 [Peterson, Thomas C.; Heim, Richard R., Jr.; Vose, Russell S.] NOAA, Natl Climat Data Ctr, Asheville, NC 28803 USA. [Hirsch, Robert] US Geol Survey, Reston, VA 22092 USA. [Kaiser, Dale P.] US DOE, Carbon Dioxide Informat Anal Ctr, Oak Ridge Natl Lab, Oak Ridge, TN USA. [Brooks, Harold] NOAA, Natl Severe Storms Lab, Norman, OK 73069 USA. [Diffenbaugh, Noah S.] Stanford Univ, Stanford, CA 94305 USA. [Dole, Randall M.; Wolter, Klaus] NOAA, Earth Syst Res Lab, Boulder, CO USA. [Giovannettone, Jason P.] US Army Corp Engineers, Inst Water Resources, Alexandria, VA USA. [Guirguis, Kristen] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. [Guirguis, Kristen] Univ Corp Atmospher Res, Boulder, CO USA. [Katz, Richard W.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Kunkel, Kenneth] Cooperat Inst Climate & Satellites, Asheville, NC USA. [Lettenmaier, Dennis] Univ Washington, Seattle, WA 98195 USA. [McCabe, Gregory J.; Wolock, David] USGS, Lawrence, KS USA. [Paciorek, Christopher J.] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA. [Ryberg, Karen R.; Vecchia, Aldo V.] US Geol Survey, Bismarck, ND USA. [Schubert, Siegfried] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Silva, Viviane B. S.] NOAA, Climate Serv Div, NWS, OCWWS, Silver Spring, MD USA. [Stewart, Brooke C.] STG, Asheville, NC USA. [Villarini, Gabriele] Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA USA. [Walsh, John] Univ Alaska Fairbanks, Fairbanks, AK USA. [Wehner, Michael] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Woodhouse, Connie A.] Univ Arizona, Tucson, AZ USA. [Wuebbles, Donald] Univ Illinois, Urbana, IL USA. RP Peterson, TC (reprint author), NOAA, Natl Climat Data Ctr, 151 Patton Ave, Asheville, NC 28803 USA. EM thomas.c.peterson@noaa.gov RI lettenmaier, dennis/F-8780-2011; Diffenbaugh, Noah/I-5920-2014; Kunkel, Kenneth/C-7280-2015; Wolter, Klaus/D-5988-2015; Katz, Richard/K-4133-2012; Ryberg, Karen/E-1871-2016; Villarini, Gabriele/F-8069-2016; OI lettenmaier, dennis/0000-0003-3317-1327; Diffenbaugh, Noah/0000-0002-8856-4964; Kunkel, Kenneth/0000-0001-6667-7047; Katz, Richard/0000-0002-0267-8953; Ryberg, Karen/0000-0002-9834-2046; Villarini, Gabriele/0000-0001-9566-2370; Hirsch, Robert/0000-0002-4534-075X NR 95 TC 84 Z9 85 U1 10 U2 132 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD JUN PY 2013 VL 94 IS 6 BP 821 EP 834 DI 10.1175/BAMS-D-12-00066.1 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 175TK UT WOS:000321256100005 ER PT J AU Goren, AD Prins, RD Dauer, LT Quinn, B Al-Najjar, A Faber, RD Patchell, G Branets, I Colosi, DC AF Goren, A. D. Prins, R. D. Dauer, L. T. Quinn, B. Al-Najjar, A. Faber, R. D. Patchell, G. Branets, I. Colosi, D. C. TI Effect of leaded glasses and thyroid shielding on cone beam CT radiation dose in an adult female phantom SO DENTOMAXILLOFACIAL RADIOLOGY LA English DT Article DE Leaded glasses; thyroid shielding; CBCT dosimetry; dose reduction; eye lens dose ID COMPUTED-TOMOGRAPHY; DENTAL RADIOGRAPHY; REDUCTION; CANCER; BREAST; HEAD AB Objectives: This study aims to demonstrate the effectiveness of leaded glasses in reducing the lens of eye dose and of lead thyroid collars in reducing the dose to the thyroid gland of an adult female from dental cone beam CT (CBCT). The effect of collimation on the radiation dose in head organs is also examined. Methods: Dose measurements were conducted by placing optically stimulated luminescent dosemeters in an anthropomorphic female phantom. Eye lens dose was measured by placing a dosemeter on the anterior surface of the phantom eye location. All exposures were performed on one commercially available dental CBCT machine, using selected collimation and exposure techniques. Each scan technique was performed without any lead shielding and then repeated with lead shielding in place. To calculate the percent reduction from lead shielding, the dose measured with lead shielding was divided by the dose measured without lead shielding. The percent reduction from collimation was calculated by comparing the dose measured with collimation to the dose measured without collimation. Results: The dose to the internal eye for one of the scans without leaded glasses or thyroid shield was 0.450 cGy and with glasses and thyroid shield was 0.116 cGy (a 74% reduction). The reduction to the lens of the eye was from 0.396 cGy to 0.153 cGy (a 61% reduction). Without glasses or thyroid shield, the thyroid dose was 0.158 cGy; and when both glasses and shield were used, the thyroid dose was reduced to 0.091 cGy (a 42% reduction). Conclusions: Collimation alone reduced the dose to the brain by up to 91%, with a similar reduction in other organs. Based on these data, leaded glasses, thyroid collars and collimation minimize the dose to organs outside the field of view. C1 [Goren, A. D.; Branets, I.] NYU, Coll Dent, Dept Cariol & Comprehens Care, New York, NY 10010 USA. [Goren, A. D.; Al-Najjar, A.; Faber, R. D.; Patchell, G.; Colosi, D. C.] SUNY Stony Brook, Sch Dent Med, Dept Prosthodont & Digital Technol, Stony Brook, NY 11794 USA. [Prins, R. D.] US Army, Def Threat Reduct Agcy, Ft Belvoir, VA USA. [Dauer, L. T.; Quinn, B.] Mem Sloan Kettering Canc Ctr, Dept Med Phys & Radiol, New York, NY 10021 USA. [Al-Najjar, A.; Faber, R. D.] Stony Brook Sch Dent Med, Dept Orthodont, Stony Brook, NY USA. RP Goren, AD (reprint author), NYU, Coll Dent, New York, NY 10010 USA. EM sag2172@aol.com OI Dauer, Lawrence/0000-0002-5629-8462 NR 36 TC 10 Z9 10 U1 0 U2 7 PU BRITISH INST RADIOLOGY PI LONDON PA 36 PORTLAND PLACE, LONDON W1N 4AT, ENGLAND SN 0250-832X J9 DENTOMAXILLOFAC RAD JI Dentomaxillofac. Radiol. PD JUN PY 2013 VL 42 IS 6 AR 20120260 DI 10.1259/dmfr.20120260 PG 7 WC Dentistry, Oral Surgery & Medicine; Radiology, Nuclear Medicine & Medical Imaging SC Dentistry, Oral Surgery & Medicine; Radiology, Nuclear Medicine & Medical Imaging GA 168BC UT WOS:000320679700004 PM 23412460 ER PT J AU McDonald, RMS AF McDonald, Robert M. S. TI The Papers of Thomas Jefferson, Retirement Series, vol 6, 11 March to 27 November 1813 SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [McDonald, Robert M. S.] US Mil Acad, West Point, NY 10996 USA. RP McDonald, RMS (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2013 VL 100 IS 1 BP 190 EP 191 DI 10.1093/jahist/jat028 PG 2 WC History SC History GA 160OJ UT WOS:000320128700030 ER PT J AU Williams, BR Hulet, MS Brozena, A Miles, RW Tevault, DE AF Williams, Barry R. Hulet, Melissa S. Brozena, Ann Miles, Ronald W., Jr. Tevault, David E. TI Vapor Pressure of 2-Dialkyl Aminoethanethiols SO JOURNAL OF CHEMICAL AND ENGINEERING DATA LA English DT Article AB The vapor pressures of three 2-dialkyl aminoethanethiol compounds, 2-dimethyl aminoethanethiol (DMA), 2-diethyl aminoethanethiol (DEA), and 2-diisopropyl aminoethanethiol (DIA), have been determined using complementary methods that enable data collection in the ambient and high temperature ranges using vapor saturation and differential scanning calorimetry, respectively. Previously published vapor pressure data for these materials are sparse, conflicting, and limited in the pressure ranges covered. This work greatly expands the experimental range and, owing to the good agreement obtained using complementary methods, significantly enhances confidence in the accuracy of the measured data. In addition to the observed data, this report includes derived properties, that is, temperature-dependent volatility and heats of vaporization. C1 [Williams, Barry R.; Hulet, Melissa S.] Sci Applicat Int Corp, Gunpowder, MD 21010 USA. [Brozena, Ann; Miles, Ronald W., Jr.; Tevault, David E.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, RDCB DR, Aberdeen Proving Ground, MD 21010 USA. RP Tevault, DE (reprint author), US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, RDCB DR, Aberdeen Proving Ground, MD 21010 USA. EM david.e.tevault.ctr@mail.mil NR 28 TC 3 Z9 3 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9568 J9 J CHEM ENG DATA JI J. Chem. Eng. Data PD JUN PY 2013 VL 58 IS 6 BP 1679 EP 1684 DI 10.1021/je400136y PG 6 WC Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 167OK UT WOS:000320641100034 ER PT J AU Wilson, WR Magnussen, RA Irribarra, LA Taylor, DC AF Wilson, William R. Magnussen, Robert A. Irribarra, Luis A. Taylor, Dean C. TI Variability of the capsular anatomy in the rotator interval region of the shoulder SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Anatomy; shoulder; rotator interval; anatomic variability; arthroscopy ID GLENOHUMERAL LIGAMENTS; INSTABILITY; COMPLEX; ANTERIOR; CLOSURE; PATHOLOGY; HISTOLOGY AB Purpose: Anterior shoulder anatomy is as complex and variable as its descriptive terminology. A detailed understanding of normal anatomic variability is critical to accurate performance, description, and evaluation of the procedures involving the rotator interval. We aimed to define, arthroscopically, the anatomic variability in the rotator interval region of the shoulder and to compare these results to the findings of previous cadaveric studies. Methods: The rotator interval anatomy of 104 consecutive patients was classified according to the system of DePalma. Anatomic variability was evaluated and compared with findings of previous authors. Results: Shoulders were classified as follows: 59% type 1 (rotator interval capsular opening [RICO] superolateral to the MGHL); 1% type 2 (RICO inferomedial to the middle glenohumeral ligament [MGHL]); 22% type 3 (2 RICOs: 1 above and 1 below the MGHL); 9% type 4 (large RICO, no MGHL); 0% type 5 (the MGHL is manifested as 2 small RICOs); 7% Type 6 (no RICO); and 3% distinct Buford complex. We found a larger percentage of type 1 shoulders and a lower percentage of type 3 shoulders relative to prior open cadaveric dissections. No difference in the distribution of DePalma types was noted based surgical indication. Conclusions: The anatomy of the rotator interval as viewed arthroscopically is complex and variable. While DePalma types 1 and 3 are most commonly encountered, other anatomic variants are frequent and should be considered when assessing and manipulating structures in region of the rotator interval and anterior shoulder. Level of evidence: Basic Science, Anatomy Study, In-Vivo. (C) 2013 Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Wilson, William R.] Eisenhower Army Med Ctr, Orthopaed Surg Serv, Ft Gordon, GA USA. [Magnussen, Robert A.] Ohio State Univ, Dept Orthopaed, OSU Sports Med Sports Hlth & Performance Inst, Columbus, OH 43210 USA. [Irribarra, Luis A.] Pontificia Univ Catolica Chile, Dept Orthopaed, Santiago, Chile. [Taylor, Dean C.] Duke Univ, Med Ctr, Durham, NC 27710 USA. RP Taylor, DC (reprint author), Duke Univ, Med Ctr, Box 3615, Durham, NC 27710 USA. EM dean.taylor@duke.edu RI Magnussen, Robert/B-6177-2012 NR 18 TC 2 Z9 2 U1 0 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD JUN PY 2013 VL 22 IS 6 BP 856 EP 861 DI 10.1016/j.jse.2012.08.024 PG 6 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA 172IP UT WOS:000320995800027 PM 23177168 ER PT J AU Fifer, AM AF Fifer, Angela M. TI Introduction to Sport Psychology Consulting: Working With Coaches and Teams. SO SPORT PSYCHOLOGIST LA English DT Book Review C1 [Fifer, Angela M.] US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. RP Fifer, AM (reprint author), US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 1 U2 6 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0888-4781 J9 SPORT PSYCHOL JI Sport Psychol. PD JUN PY 2013 VL 27 IS 2 BP 212 EP 212 PG 1 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 174MD UT WOS:000321158800010 ER PT J AU Drake, B Paterson, R Cushing, T Tabin, G Butler, F AF Drake, Brandy Paterson, Ryan Cushing, Tracy Tabin, Geoffrey Butler, Frank TI In Response to WMS Practice Guidelines for Eye Injuries and Illnesses Reply SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Letter C1 [Drake, Brandy; Paterson, Ryan; Cushing, Tracy] Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA. [Tabin, Geoffrey] Univ Utah, Sch Med, Salt Lake City, UT USA. [Butler, Frank] USA, Inst Surg Res, Comm Tact Combat Casualty Care, Def Board, Ft Sam Houston, TX 78234 USA. RP Drake, B (reprint author), Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD SUM PY 2013 VL 24 IS 2 BP 182 EP 183 PG 2 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 162UB UT WOS:000320290400025 PM 23578706 ER PT J AU Birchak, JC Rochette, LM Smith, GA AF Birchak, John C. Rochette, Lynne M. Smith, Gary A. TI Softball injuries treated in US EDs, 1994 to 2010 SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID HIGH-SCHOOL BASEBALL; UNITED-STATES; EMERGENCY-DEPARTMENTS; SPORTS; PREVENTION; EPIDEMIOLOGY; SURVEILLANCE; PATTERNS AB Background: Softball is a popular participant sport in the United States. This study investigated the epidemiology of softball injuries with comparisons between children and adults. Methods: Data from the National Electronic Injury Surveillance System for patients 7 years and older treated in an emergency department (ED) for a softball injury from 1994 through 2010 were analyzed. Results: An estimated 2107823 (95% confidence interval [CI], 1736417-2479229) patients were treated in US EDs for a softball injury during the 17-year study period. The annual number of injuries decreased by 23.0% from 1994 to 2010 (P < .001); however, during the last 6 years of the study, injuries increased by 11.7% (P = .008). The annual rate of softball injuries increased significantly during the study period (P = .035). The most commonly injured body regions were the hand/wrist (22.2%) and face (19.3%). Being hit by a ball was the most common mechanism of injury (52.4%) and accounted for most of face (89.6%) and head (75.7%) injuries. Injuries associated with running (relative risk, 2.36; 95% CI, 1.97-2.82) and diving for a ball (relative risk, 4.61; 95% CI, 3.50-6.09) were more likely to occur among adult than pediatric patients. Conclusions: To our knowledge, this is the first study to investigate softball injuries using a nationally representative sample. Softball is a common source of injury among children and adults. Increased efforts are needed to promote safety measures, such as face guards, mouth guards, safety softballs, and break-away bases, to decrease these injuries. (C) 2013 Elsevier Inc. All rights reserved. C1 [Birchak, John C.; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Ctr Injury Res & Policy, Res Inst, Columbus, OH 43205 USA. [Birchak, John C.; Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA. [Rochette, Lynne M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA. RP Smith, GA (reprint author), Nationwide Childrens Hosp, Ctr Injury Res & Policy, Res Inst, Columbus, OH 43205 USA. EM gary.smith@nationwidechildrens.org FU Medical Student Research Scholarship Fund of The Ohio State University College of Medicine FX The authors have no conflicts of interest or financial disclosures relevant to this article to declare. John C. Birchak received a student research scholarship from the Medical Student Research Scholarship Fund of The Ohio State University College of Medicine while he worked on this study.; We thank Natalie McIlvain for her helpful comments and suggestions. The authors also gratefully acknowledge support from the Medical Student Research Scholarship Fund of The Ohio State University College of Medicine, which provided a student research stipend for author JCB, while he worked on this study. Interpretations and conclusions expressed in this article do not necessarily represent those of the funding institution. NR 32 TC 4 Z9 4 U1 1 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JUN PY 2013 VL 31 IS 6 BP 900 EP 905 DI 10.1016/j.ajem.2013.02.039 PG 6 WC Emergency Medicine SC Emergency Medicine GA 167SO UT WOS:000320655100002 PM 23602754 ER PT J AU Bryson, AJ Woodley, CM Karls, RK Hall, KD Weiland, MA Deng, ZD Carlson, TJ Eppard, MB AF Bryson, Amanda J. Woodley, Christa M. Karls, Rhonda K. Hall, Kathleen D. Weiland, Mark A. Deng, Z. Daniel Carlson, Thomas J. Eppard, M. Brad TI Comparison of 180-degree and 90-degree needle rotation to reduce wound size in PIT-injected juvenile Chinook salmon SO FISHERIES RESEARCH LA English DT Article DE Fish telemetry; Passive integrated transponder; Acoustic telemetry; Wound healing; Injection techniques ID INTEGRATED TRANSPONDER TAGS; RETENTION; MORTALITY; SURVIVAL; IMPLANTATION; PERFORMANCE; BEVEL AB Most telemetry studies require the implantation or attachment of passive transponders or active transmitters to monitor and assess fish stocks and conservation to gain an understanding of fish physiology and behavior. As new telemetry technologies become available, it is imperative to study the effect of the transmitter or implantation technique on species of interest. In this study, we investigated the effects of needle axial or bevel rotation (0-, 90-, 180-degree) on wound extent and healing, and tag loss in juvenile Chinook salmon injected with an 8-gauge needle, which is required for implantation of the injectable juvenile Salmon Acoustic Telemetry Systems acoustic transmitter and some passive integrated transponders (PITs). Although the wounds were not closed after injection (e.g., with sutures or glue), there were no mortalities, dropped tags, or indications of fungus, ulceration, or redness around the wound. No axial rotation (0-degrees) resulted in the PIT tag frequently misloading or falling out before injection. On Day 0 and post-implantation Day 7, the 90-degree bevel rotation produced a significantly smaller wound extent than the 180-degree bevel rotation. Given the wound extent compared to size of fish, we recommend researchers should consider a 90-degree rotation over the 180-degree rotation when injecting transmitters. (C) 2013 Elsevier B.V. All rights reserved. C1 [Bryson, Amanda J.; Woodley, Christa M.; Karls, Rhonda K.; Hall, Kathleen D.; Carlson, Thomas J.] Pacific NW Natl Lab, Sequim, WA 98382 USA. [Weiland, Mark A.] Pacific NW Natl Lab, North Bonneville, WA 98369 USA. [Deng, Z. Daniel] Pacific NW Natl Lab, Richland, WA 99354 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA. RP Woodley, CM (reprint author), Pacific NW Natl Lab, 1529W Sequim Bay Rd, Sequim, WA 98382 USA. EM christa.woodley@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU United States Army Corps of Engineers FX This research was funded by United States Army Corps of Engineers as part of the bio-effects research for the JSATS injectable acoustic transmitter development project. We thank PNNL staff Tim Linley, Shon Zimmerman, Katie Wagner, Eric Fischer, Ron Kaufmann, John Vavrinec, Michele Halvorsen, Lara Aston, and Jayson Martinez for technical and graphical support. In addition, we thank Susan Ennor and Amoret Bunn for the editorial review and comments. NR 18 TC 2 Z9 2 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 J9 FISH RES JI Fish Res. PD JUN PY 2013 VL 143 BP 201 EP 204 DI 10.1016/j.fishres.2013.02.011 PG 4 WC Fisheries SC Fisheries GA 151WS UT WOS:000319491700022 ER PT J AU Darlington, DN Gonzales, MD AF Darlington, Daniel N. Gonzales, Mary D. TI HPLC DETERMINATION OF VALPROIC ACID IN PLASMA BY CONJUGATION TO A HYDRAZIDE SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES LA English DT Article DE DCCH; fluorescence; HPLC; plasma; valproic acid ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HEMORRHAGIC-SHOCK; RODENT MODEL; DERIVATIZATION; RESUSCITATION; CARBODIIMIDE AB We developed a method to measure plasma levels of valproic acid (VA) using pre-column conjugation of VA to the fluorescent probe, 7-diethylaminocoumarin-3-carboxylic acid, hydrazide (DCCH). Swine plasma was spiked with varying concentration of VA. 2-phenylbutyric acid (2PB) was used as an internal standard. VA and 2PB were extracted from plasma (10 mu L) using NaCl, MeCN, and ethyl acetate. Extraction efficiency ranged from 85-92%. After conjugation to DCCH, the VA and 2BP, conjugates were easily separated on reverse phase HPLC using a 55-70% MeCN/H2O gradient. Standard curves were generated from the absorbance (=430nm) and fluorescence ((ex)=415nm, (em)=465nm) that described an exponential curve y-a(1-b(x)) with correlation coefficients >0.97. The inter-assay variation measured over 12 days was <3% for the high pool (5mg/mL) and 10% for the low pool (0.5mg/mL). The intra-assay variation measured over 5 replicates/day was <3.5% for both the high and low pools. The calculated standard curves predicted the actual values of the standards. This assay can be used to measure plasma concentrations of VA in patients or laboratory animals being treated with VA. C1 [Darlington, Daniel N.; Gonzales, Mary D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Darlington, DN (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM daniel.darlington@us.army.mil FU US Army Medical Research Material Command FX This study has been conducted in compliance with the Animal Welfare Act, the implementing Animal Welfare Regulations, and in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. This project was funded by US Army Medical Research Material Command. We would like to thank the expert technical help of Kristi Lemke for getting the project started. NR 17 TC 1 Z9 1 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6076 J9 J LIQ CHROMATOGR R T JI J. Liq. Chromatogr. Relat. Technol. PD JUN 1 PY 2013 VL 36 IS 16 BP 2209 EP 2219 DI 10.1080/10826076.2012.717059 PG 11 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 171GG UT WOS:000320912600001 ER PT J AU Kochanek, PM Dixon, CE Shellington, DK Shin, SS Bayir, H Jackson, EK Kagan, VE Yan, HQ Swauger, PV Parks, SA Ritzel, DV Bauman, R Clark, RSB Garman, RH Bandak, F Ling, G Jenkins, LW AF Kochanek, Patrick M. Dixon, C. Edward Shellington, David K. Shin, Samuel S. Bayir, Huelya Jackson, Edwin K. Kagan, Valerian E. Yan, Hong Q. Swauger, Peter V. Parks, Steven A. Ritzel, David V. Bauman, Richard Clark, Robert S. B. Garman, Robert H. Bandak, Faris Ling, Geoffrey Jenkins, Larry W. TI Screening of Biochemical and Molecular Mechanisms of Secondary Injury and Repair in the Brain after Experimental Blast-Induced Traumatic Brain Injury in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE adenosine; antioxidant; ascorbate; ATP; axonal injury; chemokine; combat casualty care; cyclic AMP; cytokine; gene array; glutathione; improvised explosive device; lipid peroxidation; multiplex; post-traumatic stress disorder; purine ID POSTTRAUMATIC-STRESS-DISORDER; HUMAN CEREBROSPINAL-FLUID; PROTEIN-KINASE-II; OXIDATIVE STRESS; EXPLOSIVE BLAST; GENE-EXPRESSION; INDUCED NEUROTRAUMA; MILITARY PERSONNEL; MODEL; CELLS AB Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic stress disorder, memory loss, and chronic traumatic encephalopathy. In this article we report on blast-induced mild TBI (mTBI) characterized by fiber-tract degeneration and axonal injury revealed by cupric silver staining in adult male rats after head-only exposure to 35 psi in a helium-driven shock tube with head restraint. We now explore pathways of secondary injury and repair using biochemical/molecular strategies. Injury produced similar to 25% mortality from apnea. Shams received identical anesthesia exposure. Rats were sacrificed at 2 or 24 h, and brain was sampled in the hippocampus and prefrontal cortex. Hippocampal samples were used to assess gene array (RatRef-12 Expression BeadChip; Illumina, Inc., San Diego, CA) and oxidative stress (OS; ascorbate, glutathione, low-molecular-weight thiols [LMWT], protein thiols, and 4-hydroxynonenal [HNE]). Cortical samples were used to assess neuroinflammation (cytokines, chemokines, and growth factors; Luminex Corporation, Austin, TX) and purines (adenosine triphosphate [ATP], adenosine diphosphate, adenosine, inosine, 2'-AMP [adenosine monophosphate], and 5'-AMP). Gene array revealed marked increases in astrocyte and neuroinflammatory markers at 24 h (glial fibrillary acidic protein, vimentin, and complement component 1) with expression patterns bioinformatically consistent with those noted in Alzheimer's disease and long-term potentiation. Ascorbate, LMWT, and protein thiols were reduced at 2 and 24 h; by 24 h, HNE was increased. At 2 h, multiple cytokines and chemokines (interleukin [IL]-1 alpha, IL-6, IL-10, and macrophage inflammatory protein 1 alpha [MIP-1 alpha]) were increased; by 24 h, only MIP-1 alpha remained elevated. ATP was not depleted, and adenosine correlated with 2'-cyclic AMP (cAMP), and not 5'-cAMP. Our data reveal (1) gene-array alterations similar to disorders of memory processing and a marked astrocyte response, (2) OS, (3) neuroinflammation with a sustained chemokine response, and (4) adenosine production despite lack of energy failure-possibly resulting from metabolism of 2'-3'-cAMP. A robust biochemical/molecular response occurs after blast-induced mTBI, with the body protected from blast and the head constrained to limit motion. C1 [Kochanek, Patrick M.; Dixon, C. Edward; Shin, Samuel S.; Bayir, Huelya; Yan, Hong Q.; Clark, Robert S. B.; Jenkins, Larry W.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. [Kochanek, Patrick M.; Bayir, Huelya; Clark, Robert S. B.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA 15260 USA. [Dixon, C. Edward; Shin, Samuel S.; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Garman, Robert H.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USA. [Jackson, Edwin K.] Univ Pittsburgh, Sch Med, Dept Med Pharmacol, Pittsburgh, PA 15260 USA. [Bayir, Huelya; Kagan, Valerian E.] Univ Pittsburgh, Sch Med, Dept Environm & Occupat Hlth, Pittsburgh, PA 15260 USA. [Bayir, Huelya; Kagan, Valerian E.] Univ Pittsburgh, Sch Med, Pittsburgh Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15260 USA. [Shellington, David K.] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA. [Swauger, Peter V.; Parks, Steven A.] ORA Inc, Fredericksburg, VA USA. [Bauman, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ritzel, David V.] Dyn FX Consulting Ltd, Amherstburg, ON, Canada. [Bandak, Faris; Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Neurol, Bethesda, MD 20814 USA. [Bandak, Faris] Integrated Serv Grp Inc, Potomac, MD USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 5th Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu RI Kochanek, Patrick/D-2371-2015; OI Kochanek, Patrick/0000-0002-2627-913X; Shellington, David/0000-0001-6708-6978 FU DARPA PREVENT [N660001-10C2124] FX This work was supported by DARPA PREVENT (N660001-10C2124). The authors thank Keri Janesko-Feldman and Jeremy Henchir for their technical support. The authors thank Marci Provins and Fran Mistrick for their help with manuscript preparation. Microarray data were generated by the Genomics Core Laboratory, University of Pittsburgh, and statistical analyses were performed by the GPCL-Bioinformatics Analysis Core (GPCL-BAC), University of Pittsburgh. The authors thank Dr. James Lyons-Weiler for his valuable assistance. The views, opinions, and/or findings contained in this article are those of the authors and should not be interpreted as representing the official views or policies either expressed or implied of DARPA or the DoD. This work has been approved for public release, distribution unlimited. NR 63 TC 32 Z9 32 U1 1 U2 22 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2013 VL 30 IS 11 BP 920 EP 937 DI 10.1089/neu.2013.2862 PG 18 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 166WD UT WOS:000320589300003 PM 23496248 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI "A Better War?'-The View from the Nixon White House SO JOURNAL OF STRATEGIC STUDIES LA English DT Article DE Vietnam War; Civil-Military Relations; Strategy; Richard Nixon; Creighton Abrams AB This article examines the relationship between the White House and the US Military Assistance Command, Vietnam (MACV) during President Richard M. Nixon's administration. It argues that dysfunctional civil-military relations between 1969 and 1972 undermined the implementation of a sound military strategy during the United States' withdrawal from South Vietnam as Nixon attempted to achieve peace with honor' during the Vietnam War's final campaigns. By 1972, the relationship between the White House and MACV headquarters had reached the nadir of civil-military relations during the Southeast Asian conflict and had served to undercut the United States' ability to effectively disengage from a long and bitterly contested war. C1 US Mil Acad, Dept Hist, West Point, NY 10996 USA. RP Daddis, GA (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA. NR 84 TC 2 Z9 2 U1 1 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0140-2390 J9 J STRATEGIC STUD JI J. Strateg. Stud. PD JUN 1 PY 2013 VL 36 IS 3 BP 357 EP 384 DI 10.1080/01402390.2012.688173 PG 28 WC International Relations; Political Science SC International Relations; Government & Law GA 159BR UT WOS:000320019500003 ER PT J AU Manuel, KL Kirk, JP Barwick, DH Bowen, TW AF Manuel, Kenneth L. Kirk, James P. Barwick, D. Hugh Bowen, Tommy W. TI Hydrilla Management in Piedmont Reservoirs Using Herbicides and Triploid Grass Carp: A Case Study SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID SANTEE-COOPER RESERVOIRS; SOUTH-CAROLINA; CTENOPHARYNGODON-IDELLA; VEGETATION; MOVEMENTS; IMPACTS; TEXAS; RIVER; LAKE AB We developed a three-step management strategy for hydrilla Hydrilla verticillata in five Piedmont reservoirs operated by Duke Energy Corporation. This strategy involves (1) early detection of hydrilla, (2) use of registered herbicides for plant suppression along with stocking 20 triploid Grass Carp Ctenopharyngodon idella per surface acre of infestation, and (3) maintenance stocking of triploid Grass Carp to prevent hydrilla regrowth from tubers. Following this strategy, hydrilla in the water column was eliminated within one calendar year after Grass Carp introduction in four out of five reservoirs. This suggests that integrating herbicide applications with stocking Grass Carp largely eliminates the multiyear lag effect normally associated with using Grass Carp alone. A maintenance density of at least one triploid Grass Carp per eight surface acres of the reservoir prevented hydrilla regrowth except for a brief and minor reinfestation in one of five study reservoirs. This management approach proved successful when hydrilla coverage was as little as 1-3% of the reservoir's surface area. Detecting and controlling hydrilla early during the infestation should reduce the cost of management and perhaps minimize some adverse effects associated with the introduction and use of triploid Grass Carp. Received November 14, 2012; accepted January 15, 2013 C1 [Manuel, Kenneth L.; Barwick, D. Hugh; Bowen, Tommy W.] Duke Energy Corp, Water Strategy Hydro Licensing & Lake Serv, Environm Ctr MG03A3, Huntersville, NC 28078 USA. [Kirk, James P.] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Kirk, JP (reprint author), Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.p.kirk@usace.army.mil FU Aquatic Plant Control Research Program FX We thank Duke Energy Corporation mosquito control crews for their diligence in locating hydrilla infestations. We also acknowledge the contributions of K. J. Killgore, W.T. Slack, and A. Harrison-Lewis as well as two reviewers in editing and improving this article. The support of the Aquatic Plant Control Research Program is also appreciated. NR 36 TC 2 Z9 2 U1 5 U2 31 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD JUN 1 PY 2013 VL 33 IS 3 BP 488 EP 492 DI 10.1080/02755947.2013.768570 PG 5 WC Fisheries SC Fisheries GA 159CI UT WOS:000320021200004 ER PT J AU Eismann, M Perconti, P AF Eismann, Michael Perconti, Philip TI Infrared Systems SO OPTICAL ENGINEERING LA English DT Editorial Material C1 [Eismann, Michael] USAF, Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA. [Perconti, Philip] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Eismann, M (reprint author), USAF, Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA. EM michael.eismann@wpafb.af.mil; philip.perconti.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 4 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2013 VL 52 IS 6 AR 061301 PG 2 WC Optics SC Optics GA 151EV UT WOS:000319444400001 ER PT J AU Lilley, S Vizgaitis, J Everett, J Spinazzola, R AF Lilley, Scott Vizgaitis, Jay Everett, Jonathan Spinazzola, Robert TI Multifield of view see-spot optics SO OPTICAL ENGINEERING LA English DT Article DE short-wave; mid-wave; broad band; infrared; optics; catadioptric; see-spot AB The increasing availability of sensors that can image in the 1 to 5 mu m region has allowed for systems to be developed that utilize the full spectrum. Current mid-wave infrared (MWIR) systems have typically only imaged in the 3 to 5 mu m region, but the new detectors allow imaging in the short-wave infrared (SWIR) and MWIR bands on the same image plane. Night Vision and Electronic Sensors Directorate (NVESD) had a requirement to design and build a multiple field of view (FOV) optical system that could image the 1 to 5 mu m spectral band utilizing a single, cooled infrared detector. The primary challenge of designing this particular optical system was to get the 1 to 2 (SWIR) mu m band to focus at the same image plane as the 3 to 5 (MWIR) mu m band in all FOVs. A three-FOV broadband optical system that can image the 1 to 5 mu m band on the same image plane was designed and built. Several optical concepts were looked at, and it was decided that a combination of a reflective afocal and refractive imager was the best way to meet the system requirements. The use of a catadioptric system with a single focal plane that images in the 1 to 5 mu m spectrum reduces the size of the system and provides the user with see-spot capability. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Lilley, Scott; Vizgaitis, Jay] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Everett, Jonathan; Spinazzola, Robert] Gen Dynam Global Imaging Technol, Nashua, NH 03060 USA. RP Lilley, S (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM scott.j.lilley.civ@mail.mil NR 9 TC 1 Z9 1 U1 3 U2 7 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2013 VL 52 IS 6 AR 061303 DI 10.1117/1.OE.52.6.061303 PG 8 WC Optics SC Optics GA 151EV UT WOS:000319444400003 ER PT J AU Lohrmann, D Littleton, R Reese, C Murphy, D Vizgaitis, J AF Lohrmann, Dieter Littleton, Roy Reese, Colin Murphy, Dan Vizgaitis, Jay TI Uncooled long-wave infrared small pixel focal plane array and system challenges SO OPTICAL ENGINEERING LA English DT Article DE uncooled; bolometer; infrared detector; focal plane arrays; infrared imaging AB There is a strong motivation for smaller pixels based on enduser demand for lower-cost, higher-resolution camera systems both for military and commercial applications. Uncooled detector technology fits the need for a low size, weight, and power system. We explore the trade-offs and challenges to achieving pixel designs smaller than the current 17-mu m state-of-the-art detectors without loss in sensitivity or resolution. For illustration we consider a 12-mu m design. We also address modulation transfer function issues as the pixel size shrinks, and examine the difference between the performance of present devices and the theoretical performance limit for uncooled detectors. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 [Lohrmann, Dieter; Littleton, Roy; Reese, Colin; Murphy, Dan; Vizgaitis, Jay] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Lohrmann, D (reprint author), USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. EM dieter.j.lohrmann.civ@mail.mil NR 12 TC 6 Z9 8 U1 0 U2 14 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUN PY 2013 VL 52 IS 6 AR 061305 DI 10.1117/1.OE.52.6.061305 PG 6 WC Optics SC Optics GA 151EV UT WOS:000319444400005 ER PT J AU Vizgaitis, JN Hastings, A AF Vizgaitis, Jay N. Hastings, Arthur, Jr. TI Dual band infrared picture-in-picture systems SO OPTICAL ENGINEERING LA English DT Article DE dual band; mid-wave infrared; long-wave infrared; infrared; picture-in-picture; optics AB Dual band infrared focal plane arrays (FPA) are designed to act as two independent focal planes located at a common image plane which detects both the mid-wave infrared and the long-wave infrared images. The imagery produced is simultaneous and separable for the two bands. Systems utilizing these focal planes have often been designed to operate the same way as single band infrared sensors, except that two images of the same scene but different spectral bands are simultaneously captured, and displayed independently or as a fused image. An alternative method of exploiting dual band FPA is to utilize the dual band nature of the focal plane to simultaneously view different scenes. It is feasible to provide a picture-in-picture capability where one spectral band views a narrow field of view (FOV) to identify targets while the other spectral band images the wide FOV to provide situational awareness. We explore this capability, including design concepts and issues associated with the development of a dual band picture-in-picture infrared system. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Vizgaitis, Jay N.; Hastings, Arthur, Jr.] USA, Night Vision & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Vizgaitis, JN (reprint author), USA, Night Vision & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM jay.n.vizgaitis.civ@mail.mil NR 7 TC 2 Z9 3 U1 1 U2 2 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2013 VL 52 IS 6 AR 061306 DI 10.1117/1.OE.52.6.061306 PG 8 WC Optics SC Optics GA 151EV UT WOS:000319444400006 ER PT J AU Stepanov, V Willey, TM Ilavsky, J Gelb, J Qiu, HW AF Stepanov, Victor Willey, Trevor M. Ilavsky, Jan Gelb, Jeff Qiu, Hongwei TI Structural Characterization of RDX-Based Explosive Nanocomposites SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Nanoenergetics; RDX; Voids; USAXS; X-ray microscopy ID X-RAY-SCATTERING; POROSITY; IMPACT AB Recently developed cyclotrimethylene trinitramine (RDX)-based nanostructured explosive compositions were shown to exhibit greatly reduced initiation sensitivity as compared to conventional compositions prepared with coarser, micrometer-scale RDX. In particular, improvements were shown in the sensitivity towards shock and impact stimuli, key sources of inadvertent initiation. Such an improved response to mechanical stimuli is believed to be largely a result of smaller crystal and void sizes. Characterization of these structural parameters is therefore necessary in order to construct a meaningful physical description of these novel explosive compositions. Herein, we report the results of a detailed structural characterization of these novel RDX-based nanocomposites. The analyzed specimens were in pellet form with nominally 10% porosity. These results constitute an unprecedentedly complete structural picture of this new class of energetic materials. C1 [Stepanov, Victor] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Willey, Trevor M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Ilavsky, Jan] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. [Gelb, Jeff] Xradia Inc, Pleasanton, CA 94588 USA. [Qiu, Hongwei] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. RP Stepanov, V (reprint author), USA, RDECOM ARDEC, B 3028, Picatinny Arsenal, NJ 07806 USA. EM victor.stepanov.civ@mail.mil RI USAXS, APS/D-4198-2013 FU National Science Foundation/Department of Energy [NSF/CHE-0822838]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; National Science Foundation through NSF [DMR-0922522] FX ChemMatCARS Sector 15 is principally supported by the National Science Foundation/Department of Energy under grant number NSF/CHE-0822838. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. Microscopy resources used in this work were partially funded by the National Science Foundation through NSF Grant DMR-0922522. NR 23 TC 9 Z9 9 U1 2 U2 17 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2013 VL 38 IS 3 BP 386 EP 393 DI 10.1002/prep.201200151 PG 8 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 160IP UT WOS:000320113300011 ER PT J AU Walsh, MR Walsh, ME Taylor, S Ramsey, CA Ringelberg, DB Zufelt, JE Thiboutot, S Ampleman, G Diaz, E AF Walsh, Michael R. Walsh, Marianne E. Taylor, Susan Ramsey, Charles A. Ringelberg, David B. Zufelt, Jan E. Thiboutot, Sonia Ampleman, Guy Diaz, Emmanuela TI Characterization of PAX-21 Insensitive Munition Detonation Residues SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Insensitive munitions; Energetic residues; Detonations; Blow-in-place; Perchlorates ID DEPOSITION RATES AB Insensitive high explosives are being used in military munitions to counteract unintended detonations during storage and transportation. These formulations contain compounds such as 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one (NTO), which are less sensitive to shock and heat than conventional explosives. We conducted a series of four tests on snow-covered ice utilizing 60-mm mortar cartridges filled with 358g of PAX-21, a mixture of RDX, DNAN, and ammonium perchlorate. Rounds were detonated high- and low-order using a fuze simulator to initiate detonation. Blow-in-place (BIP) operations were conducted on fuzed rounds using an external donor charge or a shaped-charge initiator. Results indicate that 0.001% of the original mass of RDX and DNAN were deposited during high-order detonations, but up to 28% of the perchlorate remained. For the donor block BIPs, 1% of the RDX and DNAN remained. Residues masses for these operations were significantly higher than for conventional munitions. Low-order detonations deposited 10-15% of their original explosive filler in friable chunks up to 5.2g in mass. Shaped-charge BIPs scattered 15% of the filler and produced chunks up to 15g. Ammonium perchlorate residue masses were extremely high because of the presence of large AP crystals, up to 400m in the recovered particles. C1 [Walsh, Michael R.; Walsh, Marianne E.; Taylor, Susan; Ringelberg, David B.; Zufelt, Jan E.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ramsey, Charles A.] Envirostat Inc, Ft Collins, CO 80522 USA. [Thiboutot, Sonia; Ampleman, Guy; Diaz, Emmanuela] Canada Valcartier, Def Res & Dev, Val Belair, PQ G3J 1X5, Canada. RP Walsh, MR (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil NR 21 TC 10 Z9 11 U1 0 U2 25 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2013 VL 38 IS 3 BP 399 EP 409 DI 10.1002/prep.201200150 PG 11 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 160IP UT WOS:000320113300013 ER PT J AU Moretti, JD Sabatini, JJ Shaw, AP Chen, G Gilbert, RA Oyler, KD AF Moretti, Jared D. Sabatini, Jesse J. Shaw, Anthony P. Chen, Gary Gilbert, Robert A., Jr. Oyler, Karl D. TI Prototype Scale Development of an Environmentally Benign Yellow Smoke Hand-Held Signal Formulation Based on Solvent Yellow 33 SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Hand-held signal; Solvent Yellow 33; Energetic materials; Pyrotechnics; Sustainable chemistry; Product life cycle management ID PERCHLORATE-FREE; THERMAL-DECOMPOSITION; CIVILIAN APPLICATIONS; LIGHT ILLUMINANTS; PYROTECHNICS; HYDROMAGNESITE; MILITARY AB We report herein the development of an environmentally benign yellow smoke formulation aimed to replace the environmentally hazardous mixture currently specified for the U.S. Army's M194 yellow smoke hand-held signal. Static ignition test measurements have identified a replacement candidate that generates a robust fountain of yellow smoke, burning for 15 s from a consolidated cardboard tube configuration. This new formulation meets the burn time parameters outlined in the military requirement and is composed entirely of dry, powdered, solid ingredients without the need for solvent-based binders. In addition, this formulation was found to have relatively low sensitivity to impact, friction, and electrostatic discharge. C1 [Moretti, Jared D.; Sabatini, Jesse J.; Shaw, Anthony P.; Chen, Gary; Gilbert, Robert A., Jr.] USA, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Oyler, Karl D.] USA, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Moretti, JD (reprint author), USA, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM jared.d.moretti.civ@mail.mil; jesse.j.sabatini.civ@mail.mil FU Ordnance Environmental Program - Environmental Quality Technology (OEP-EQT) program of the U.S. Army Research, Development, and Engineering Command (RDECOM) FX The authors gratefully acknowledge the Ordnance Environmental Program - Environmental Quality Technology (OEP-EQT) program of the U.S. Army Research, Development, and Engineering Command (RDECOM) for funding this work. Special thanks are due to Dr. Rajendra K. Sadangi for performing powder XRD analysis of Mg5(CO3)4(OH)2center dot 4H2O, and to Mr. Eric A. Latalladi and Mr. Steve Taggart for performing all pilot plant operations. This manuscript has been approved by the U.S. government for public release; distribution is unlimited. NR 32 TC 8 Z9 8 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUN PY 2013 VL 1 IS 6 BP 673 EP 678 DI 10.1021/sc400073p PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA 159AD UT WOS:000320015500016 ER PT J AU Yin, WH Xu, F Ertorer, O Pan, Z Zhang, XY Kecskes, LJ Lavernia, EJ Wei, Q AF Yin, W. H. Xu, F. Ertorer, O. Pan, Z. Zhang, X. Y. Kecskes, L. J. Lavernia, E. J. Wei, Q. TI Mechanical behavior of microstructure engineered multi-length-scale titanium over a wide range of strain rates SO ACTA MATERIALIA LA English DT Article DE Titanium; Ti; Microstructure; Mechanical behavior; Adiabatic shear band ID SHEAR-BAND FORMATION; SEVERE PLASTIC-DEFORMATION; CHANNEL ANGULAR EXTRUSION; HIGH-TENSILE DUCTILITY; ALPHA-TITANIUM; HYDROGEN EMBRITTLEMENT; FLOW-STRESS; NANOCRYSTALLINE MATERIALS; INTERSTITIAL SOLUTES; LOCALIZATION THEORY AB In this work, we studied the mechanical behavior of commercial purity Ti powder consolidates with an engineered microstructure containing multiple-length-scale features, over a wide range of loading rates. The microstructural length scales were engineered by mixing powders of different sizes, followed by either hot quasi-isostatic forging (QIF) or spark plasma sintering (SPS). We used electron back-scatter diffraction and transmission electron microscopy to examine the microstructure of the Ti materials. A bimodal grain size distribution has been achieved for the majority of the QIFed samples, while those consolidated via SPS exhibit a near-equiaxed morphology. All samples synthesized with powders milled in liquid argon show considerable uniform plastic deformation under quasi-static compression, with no failure, and their strength values are considerably high when compared to those of commercial purity Ti. Moreover, the materials consolidated from milled powders exhibit adiabatic shear banding under high rate uniaxial compression via the Kolsky bar technique. Samples prepared from a preselected proportion of powders milled in liquid nitrogen showed quasi-static strength as high as 2000 MPa, and dynamic peak stress as high as 2700 MPa, comparable to the strength of high-strength steels. However, these super-strong Ti samples are brittle under both quasi-static and dynamic compression. The strengthening of these Ti materials with an engineered microstructure is primarily attributed to the presence of interstitials. Twins were observed in nanometer-sized grains in the strongest and brittle samples, along with evidence of the TiN phase, which was attributed to exposure to a high level of nitrogen introduced during milling in liquid nitrogen. The high rate behavior can be rationalized on the basis of an adiabatic shear band model that takes into account strain and strain rate hardening. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Yin, W. H.; Pan, Z.; Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Xu, F.; Zhang, X. Y.] Chongqing Univ, Sch Mat Sci & Engn, Chongqing 400030, Peoples R China. [Ertorer, O.; Lavernia, E. J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Kecskes, L. J.] USA, WMRD, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. EM lavernia@ucdavis.edu; qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Lavernia, Enrique/I-6472-2013; Kecskes, Laszlo/F-6880-2014; Pan, Zhiliang/A-8061-2009 OI Lavernia, Enrique/0000-0003-2124-8964; Kecskes, Laszlo/0000-0002-1342-3729; Pan, Zhiliang/0000-0003-3899-8761 FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; NSF [DMR-1210437]; ONR [N00014-12-1-0237]; National Natural Science Foundation of China [51071183, 51271208]; Fundamental Research Funds for the Central Universities [CDJXS11132225]; Major State Basic Research Development Program of China (973 Program) [2010CB631004] FX This work has been supported by the US Army Research Laboratory under Contract Nos. W911QX-06-C-0124 and W911QX-08-C-0073. E.J. Lavernia gratefully acknowledges support by NSF Grant DMR-1210437 and ONR Grant N00014-12-1-0237. X.Y. Zhang thanks the National Natural Science Foundation of China (Contract Nos. 51071183, 51271208), Fundamental Research Funds for the Central Universities (Contract No. CDJXS11132225) and Major State Basic Research Development Program of China (973 Program) (Contract No. 2010CB631004). We would like to thank Dr. Mathaudhu for helpful discussion. NR 89 TC 9 Z9 10 U1 2 U2 80 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JUN PY 2013 VL 61 IS 10 BP 3781 EP 3798 DI 10.1016/j.actamat.2013.03.011 PG 18 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 149FM UT WOS:000319304400023 ER PT J AU Subhash, G Ghosh, D Blaber, J Zheng, JQ Halls, V Masters, K AF Subhash, Ghatu Ghosh, Dipankar Blaber, Justin Zheng, James Q. Halls, Virginia Masters, Karl TI Characterization of the 3-D amorphized zone beneath a Vickers indentation in boron carbide using Raman spectroscopy SO ACTA MATERIALIA LA English DT Article DE Boron carbide; Amorphization; Micro-Raman spectroscopy; Vickers indentation ID VIBRATIONAL PROPERTIES; ATOMIC-STRUCTURE; SILICON-CARBIDE; CRACK SYSTEM; CERAMICS; DAMAGE; HARDNESS; PLASTICITY; PRESSURE; BEHAVIOR AB In boron carbide (B4C), the loss of crystallinity (i.e. amorphization) during high-pressure loading is known to result in reduced hardness and inferior ballistic performance. In this investigation, a systematic procedure is developed to evaluate the size and shape of the amorphized zone as well as the spatial distribution of the amorphization intensity beneath a Vickers indentation. This is accomplished by successive metallographic polishing and material removal from the indented surface at submicron depth increments and then scanning of each surface using micro-Raman spectrometry to construct a three-dimensional map of the amorphized zone. The amorphized zone in B4C extends to a depth of almost seven times the indentation depth. The self-similarity in stress fields at various depths is also confirmed from quantitative description of the Raman peaks for various loads. Damage evolution in the form of a Mescall zone and initiation of radial cracking from the amorphized zone were also observed. It is inferred that the amorphization process initiates as soon as the indenter tip makes contact with the B4C surface and thereafter the indenter penetrates into the weakened amorphized material. The implications of this observation and the utility of the quantitative information on the size and shape of the measured amorphized zone for calibration of multiscale models on structural changes in B4C are discussed. (c) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Subhash, Ghatu; Ghosh, Dipankar; Blaber, Justin] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Ghosh, Dipankar] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA. [Blaber, Justin] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA. [Zheng, James Q.; Halls, Virginia; Masters, Karl] USA, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM subhash@ufl.edu NR 34 TC 14 Z9 14 U1 1 U2 54 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD JUN PY 2013 VL 61 IS 10 BP 3888 EP 3896 DI 10.1016/j.actamat.2013.03.028 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 149FM UT WOS:000319304400033 ER PT J AU Chang, JH Warren, TK Zhao, XS Gill, T Guo, F Wang, LJ Comunale, MA Du, YM Alonzi, DS Yu, WQ Ye, H Liu, F Guo, JT Mehta, A Cuconati, A Butters, TD Bavari, S Xu, XD Block, TM AF Chang, Jinhong Warren, Travis K. Zhao, Xuesen Gill, Tina Guo, Fang Wang, Lijuan Comunale, Mary Ann Du, Yanming Alonzi, Dominic S. Yu, Wenquan Ye, Hong Liu, Fei Guo, Ju-Tao Mehta, Anand Cuconati, Andrea Butters, Terry D. Bavari, Sina Xu, Xiaodong Block, Timothy M. TI Small molecule inhibitors of ER alpha-glucosidases are active against multiple hemorrhagic fever viruses SO ANTIVIRAL RESEARCH LA English DT Article DE ER alpha-glucosidase; Imino sugar; Hemorrhagic fever virus; Ebola virus; Marburg virus ID VIRAL DIARRHEA VIRUS; SUGAR N-BUTYLDEOXYNOJIRIMYCIN; LETHAL MOUSE MODEL; HEPATITIS-C VIRUS; DENGUE VIRUS; FILOVIRUS INFECTIONS; ANTIVIRAL ACTIVITY; B-VIRUS; GLYCOSYLATION; DERIVATIVES AB Host cellular endoplasmic reticulum alpha-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins that use the calnexin mediated folding pathway. Inhibition of these glycan processing enzymes leads to the misfolding and degradation of these viral glycoproteins and subsequent reduction in virion secretion. We previously reported that, CM-10-18, an imino sugar alpha-glucosidase inhibitor, efficiently protected the lethality of dengue virus infection of mice. In the current study, through an extensive structure-activity relationship study, we have identified three CM-10-18 derivatives that demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. Moreover, the three novel imino sugars significantly reduced the mortality of two of the most pathogenic hemorrhagic fever viruses, Marburg virus and Ebola virus, in mice. Our study thus proves the concept that imino sugars are promising drug candidates for the management of viral hemorrhagic fever caused by variety of viruses. (C) 2013 Elsevier B.V. All rights reserved. C1 [Chang, Jinhong; Zhao, Xuesen; Gill, Tina; Guo, Fang; Wang, Lijuan; Comunale, Mary Ann; Liu, Fei; Guo, Ju-Tao; Mehta, Anand; Block, Timothy M.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Drexel Inst Biotechnol & Virol Res, Doylestown, PA 18902 USA. [Warren, Travis K.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Du, Yanming; Yu, Wenquan; Ye, Hong; Cuconati, Andrea; Xu, Xiaodong; Block, Timothy M.] Inst Hepatitis & Virus Res, Doylestown, PA USA. [Alonzi, Dominic S.; Butters, Terry D.] Univ Oxford, Glycobiol Inst, Oxford, England. [Xu, Xiaodong] Enantigen Therapeut Inc, Doylestown, PA USA. RP Chang, JH (reprint author), Drexel Univ, Coll Med, Dept Microbiol & Immunol, Drexel Inst Biotechnol & Virol Res, 3805 Old Easton Rd, Doylestown, PA 18902 USA. EM jinhong.chang@drexelmed.edu RI LIU, FEI/H-2783-2013 FU Transformational Medical Technologies program from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA) [HDTRA1-09-CHEM-BIO-BAA]; NIH [AI061441, AI084267-0109]; Hepatitis B Foundation through Commonwealth of Pennsylvania; Glycobiology Institute FX We thank Matthew Campagna for technical support. This project was supported by Transformational Medical Technologies program contract [HDTRA1-09-CHEM-BIO-BAA] from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA), NIH grants (AI061441 and AI084267-0109) and by the Hepatitis B Foundation through an appropriation from the Commonwealth of Pennsylvania. DAS and TDB thank the Glycobiology Institute for support. NR 45 TC 26 Z9 27 U1 2 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JUN PY 2013 VL 98 IS 3 BP 432 EP 440 DI 10.1016/j.antiviral.2013.03.023 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 162WJ UT WOS:000320296400011 PM 23578725 ER PT J AU Wu, XW Walters, TJ Rathbone, CR AF Wu, Xiaowu Walters, Thomas J. Rathbone, Christopher R. TI Skeletal muscle satellite cell activation following cutaneous burn in rats SO BURNS LA English DT Article DE Muscle precursor cell; Thermal injury; Atrophy; Skeletal muscle; Activation ID HEPATOCYTE GROWTH-FACTOR; HYPERMETABOLIC RESPONSE; PROTEIN BREAKDOWN; INJURY; EXPRESSION; APOPTOSIS; FIBERS; PROLIFERATION; HYPERTROPHY; DYSFUNCTION AB Background: Cutaneous burn distant from skeletal muscles induces atrophy; however, its effect on muscle stem cells resident in skeletal muscle (satellite cells) distal to burn is not known. Methods: Satellite cell activation was measured in predominantly fast-twitch [tibialis anterior, extensor digitorum longus (EDL), plantaris, and gastrocnemius] and slow-twitch (soleus) muscles of rats that received either 40% total body surface area full-thickness scald burn or sham burn to the trunk area by determining bromodeoxyuridine incorporation, MyoD, and Pax7 immunohistochemistry in vivo <= 48 h after burn. To determine the effects of circulating factors on satellite cell activation, satellite cell cultures were treated with serum from sham or burn rats. Results: In vivo activation of satellite cells was increased in fast muscles isolated from burn as compared to sham animals, whereas a significant response was not seen in slow muscles. Serum taken from animals in the burn group increased the activation of satellite cells isolated from both sham and burn animals in vitro, suggesting that circulating factors have the potential to increase satellite cell activation following burn. Conclusions: Increases in satellite cell activation in muscles distal to burn are fiber-type-dependent, and circulating factors may play a role in the activation of satellite cells following burn. A better understanding of the impact of burn on satellite cell functionality will allow us to identify the cellular mechanisms of long-term muscle atrophy. (c) 2012 Elsevier Ltd and ISBI. All rights reserved. C1 [Wu, Xiaowu; Walters, Thomas J.; Rathbone, Christopher R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wu, XW (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM xiaowu.wu@amedd.army.mil FU United States Army Medical Research and Materiel Command FX We thank Ms. Melissa Sanchez for expert technical assistance. Research was supported by United States Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or reflecting the views of the US Department of Defense or the US Government. The author is an employee of the US Government. This work was prepared as part of his official duties and, as such, there is no copyright to be transferred. NR 48 TC 15 Z9 15 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD JUN PY 2013 VL 39 IS 4 BP 736 EP 744 DI 10.1016/j.burns.2012.10.016 PG 9 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 161RC UT WOS:000320210000028 PM 23146573 ER PT J AU Seay, JF Sauer, SG Frykman, PN Roy, TC AF Seay, Joseph F. Sauer, Shane G. Frykman, Peter N. Roy, Tanja C. TI A history of low back pain affects pelvis and trunk mechanics during a sustained lift/lower task SO ERGONOMICS LA English DT Article DE box lift lower; biomechanics; kinematics; physiology; manual materials handling; low back pain ID RISK-FACTORS; LIFTING EXERTIONS; LUMBAR SPINE; MOMENTS; LOAD; COORDINATION; RECURRENCE; DISORDERS; STABILITY; INJURY AB This study compared three-dimensional trunk and pelvis range of motion (ROM) during a sustained asymmetric box lift/lower task between a group with a history of low back pain (HBP, n=9) and a group with no history of low back pain (NBP, n=9). Participants lifted an 11-kg box for 10 min at 12 cycles/min from ankle height in front to shelves 45 deg off-centre at waist height. Kinematic data were collected at the beginning (min1), middle (min5) and end of the bout (min9). Two-way analyses of variance were performed for all variables. Pelvis and trunk transverse ROM were similar at min1. By min9, HBP group did not change (31.9 +/- 9 deg); however, ROM decreased in NBP group (21.6 +/- 6 deg, p < 0.05). Therefore, despite no current pain, the HBP group demonstrated protective lifting mechanics compared to controls. Also discussed are implications for studying lifting paradigms at sub-maximal effort over longer periods of time. Practitioner summary: Differences between groups over time demonstrate residual consequences of low back pain (LBP) in a manual materials handling scenario. Individuals with a history of LBP (pain free for 6 months) demonstrated more conservative lifting mechanics towards the end of the bout compared to controls with no history of LBP. C1 [Seay, Joseph F.; Sauer, Shane G.; Frykman, Peter N.; Roy, Tanja C.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. RP Seay, JF (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. EM joseph.seay@us.army.mil FU USARIEM FX The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the United States Army or the Department of Defence. Approved for public release; distribution is unlimited. Research supported in part by appointments to the Postgraduate Research Participation Program (SGS) funded by USARIEM and administered by Oak Ridge Institute for Science and Engineering. NR 36 TC 3 Z9 3 U1 1 U2 18 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD JUN 1 PY 2013 VL 56 IS 6 BP 944 EP 953 DI 10.1080/00140139.2013.781234 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 166UC UT WOS:000320582800005 PM 23586619 ER PT J AU Cho, JH Chan, KS AF Cho, Jin-Hee Chan, Kevin S. TI Building Trust-Based Sustainable Networks SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE LA English DT Article ID TECHNOLOGY DEVELOPMENT; EVOLUTION C1 [Cho, Jin-Hee; Chan, Kevin S.] USA, Res Lab, CISD, USARL, Adelphi, MD 20783 USA. RP Cho, JH (reprint author), USA, Res Lab, CISD, USARL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jin-hee.cho.civ@mail.mil FU Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (RE)) FX This research was partially supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (R&E)). The views and opinions of the author(s) do not reflect those of the DoD nor ASD (R&E). We also thank ARL's graphic designer, John A. Foster, for graphics used in this work. NR 21 TC 2 Z9 2 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0278-0097 J9 IEEE TECHNOL SOC MAG JI IEEE Technol. Soc. Mag. PD SUM PY 2013 VL 32 IS 2 BP 32 EP 38 DI 10.1109/MTS.2013.2259311 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 160OD UT WOS:000320128100006 ER PT J AU Murphy, JP Mullins, MJ Barnes, PN Haugan, TJ Levin, GA Majoros, M Sumption, MD Collings, EW Polak, M Mozola, P AF Murphy, John P. Mullins, Matthew J. Barnes, Paul N. Haugan, Timothy J. Levin, George A. Majoros, Milan Sumption, Michael D. Collings, Edward W. Polak, Milan Mozola, Pavol TI Experiment Setup for Calorimetric Measurements of Losses in HTS Coils Due to AC Current and External Magnetic Fields SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article DE AC losses; calorimetric measurement; magnetic field ID YBCO COATED CONDUCTORS; FREQUENCIES AB We present a design and details of construction of two calorimetric systems that allow us to measure the total loss in high temperature superconducting coils or linear samples carrying alternating current while exposed to a strong alternating magnetic field. This measurement technique is based on the boil-off of liquid nitrogen. The first system is designed to measure ac losses in superconducting coils in self-field generated by AC transport current. The second system contains a permanent magnet rotor and simulates the environment of an electric motor or generator. The sensitivity of the system is such that it can measure low losses from a few milliwatts to several hundred milliwatts, in either a static or dynamic magnetic field. C1 [Murphy, John P.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Mullins, Matthew J.] USAF, Res Lab, Wright Patterson AFB, OH USA. [Barnes, Paul N.] USA, Energy & Power Div, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Haugan, Timothy J.] USAF, Aerosp Syst Directorate, Res Lab, Wright Patterson AFB, OH 45433 USA. [Levin, George A.] UES, Dayton, OH 45432 USA. [Majoros, Milan; Sumption, Michael D.; Collings, Edward W.] Ohio State Univ, Columbus, OH 43210 USA. [Polak, Milan; Mozola, Pavol] Slovak Acad Sci, Bratislava 84104, Slovakia. RP Murphy, JP (reprint author), Univ Dayton, Res Inst, Dayton, OH 45469 USA. EM john.murphy.ctr@wpafb.af.mil; manaman22@gmail.com; paul.n.barnes.civ@mail.mil; timothy.haugan@wpafb.af.mil; george.levin.ctr@wpafb.af.mil; majoros@matsceng.ohio-state.edu; sumption@matsceng.ohio-state.edu; collings@ecr6.ohio-state.edu; milan.polak@savba.sk; pavol.mozola@savba.sk RI Sumption, Mike/N-5913-2016 OI Sumption, Mike/0000-0002-4243-8380 FU Air Force Research Laboratory; Air Force Office of Scientific Research; European Office of Research and Development FX This work was supported by the Air Force Research Laboratory, the Air Force Office of Scientific Research, and its European Office of Research and Development. NR 18 TC 4 Z9 4 U1 3 U2 37 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD JUN PY 2013 VL 23 IS 3 AR 4701505 DI 10.1109/TASC.2013.2237939 PN 2 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 143VA UT WOS:000318895100090 ER PT J AU Briggs, MJ Kopp, PJ Ankudinov, VK Silver, AL AF Briggs, Michael J. Kopp, Paul J. Ankudinov, Vladimir K. Silver, Andrew L. TI Comparison of Measured Ship Squat with Numerical and Empirical Methods SO JOURNAL OF SHIP RESEARCH LA English DT Article DE ship squat; numerical models; empirical formulas; ship measurements AB The Beck, Newman and Tuck (BNT) numerical predictions are used in the Coastal and Hydraulics Laboratory (CHL) Channel Analysis and Design Evaluation Tool (CADET) model for predicting underkeel clearance (UKC) resulting from ship motions and squat. The Ankudinov empirical squat prediction formula has been used in the CHL ship simulator and was recently updated. The World Association for Waterborne Transport Infrastructure (formerly The Permanent International Association of Navigation Congresses, PIANC) has recommended several empirical and physics-based formulas for the prediction of ship squat. Some of the most widely used formulas include those of Barrass, Eryuzlu, Huuska, ICORELS, Romisch, Tuck, and Yoshimura. The purpose of this article is to compare BNT, Ankudinov, and PIANC predictions with measured DGPS squat data from the Panama Canal for four ships. These comparisons demonstrate that the BNT, Ankudinov, and PIANC predictions fall within the range of squat measurements and can be used with confidence in deep draft channel design. C1 [Briggs, Michael J.] USA, Engn Res & Dev Ctr, Res Hydraul Engn Coastal & Hydraul Lab, Vicksburg, MS USA. [Kopp, Paul J.] Naval Architect, Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD USA. [Ankudinov, Vladimir K.] TRANSAS, Hydrodynam & Res Dept, Washington, DC USA. [Silver, Andrew L.] Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD USA. RP Briggs, MJ (reprint author), USA, Engn Res & Dev Ctr, Res Hydraul Engn Coastal & Hydraul Lab, Vicksburg, MS USA. NR 32 TC 1 Z9 1 U1 3 U2 10 PU SOC NAVAL ARCH MARINE ENG PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 0022-4502 J9 J SHIP RES JI J. Ship Res. PD JUN PY 2013 VL 57 IS 2 BP 73 EP 85 DI 10.5957/JOSR.57.1.120007 PG 13 WC Engineering, Marine; Engineering, Civil SC Engineering GA 164RP UT WOS:000320427500001 ER PT J AU Tran, PK Letowski, TR McBride, ME AF Tran, Phuong K. Letowski, Tomasz R. McBride, Maranda E. TI The effect of bone conduction microphone placement on intensity and spectrum of transmitted speech items SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ACQUISITION TEST CAT; BACKGROUND-NOISE; INTELLIGIBILITY; AUDIOMETRY; VIBRATOR; HEARING; DESIGN; GENDER AB Speech signals can be converted into electrical audio signals using either conventional air conduction (AC) microphone or a contact bone conduction (BC) microphone. The goal of this study was to investigate the effects of the location of a BC microphone on the intensity and frequency spectrum of the recorded speech. Twelve locations, 11 on the talker's head and 1 on the collar bone, were investigated. The speech sounds were three vowels (/u/, /a/, /i/) and two consonants (/m/, /integral/). The sounds were produced by 12 talkers. Each sound was recorded simultaneously with two BC microphones and an AC microphone. Analyzed spectral data showed that the BC recordings made at the forehead of the talker were the most similar to the AC recordings, whereas the collar bone recordings were most different. Comparison of the spectral data with speech intelligibility data collected in another study revealed a strong negative relationship between BC speech intelligibility and the degree of deviation of the BC speech spectrum from the AC spectrum. In addition, the head locations that resulted in the highest speech intelligibility were associated with the lowest output signals among all tested locations. Implications of these findings for BC communication are discussed. C1 [Tran, Phuong K.; Letowski, Tomasz R.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [McBride, Maranda E.] North Carolina Agr & Tech State Univ, Dept Management, Sch Business & Econ, Greensboro, NC 27411 USA. RP Tran, PK (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM phuong.k.tran.civ@mail.mil NR 28 TC 2 Z9 2 U1 0 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 2013 VL 133 IS 6 BP 3900 EP 3908 DI 10.1121/1.4803870 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 161EC UT WOS:000320173600033 PM 23742344 ER PT J AU Turell, MJ Byrd, BD Harrison, BA AF Turell, M. J. Byrd, B. D. Harrison, B. A. TI POTENTIAL FOR POPULATIONS OF AEDES J. JAPONICUS TO TRANSMIT RIFT VALLEY FEVER VIRUS IN THE USA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Vector; transmission; North America ID NORTH-AMERICAN MOSQUITOS; HOST-FEEDING PATTERNS; WEST-NILE-VIRUS; VECTOR COMPETENCE; UNITED-STATES; ENCEPHALITIS-VIRUS; DIPTERA-CULICIDAE; CULEX-ZOMBAENSIS; SAUDI-ARABIA; SOUTH-AFRICA AB Aedes japonicus japonicus was introduced into the northeastern USA in 1998 and has since spread to more than 25 states. Because this species has been shown to be a competent laboratory vector of several viruses, readily feeds on large mammals, and has become a pest in several areas, there is concern that it might serve as a vector of Rift Valley fever virus (RVFV) should that virus be introduced into North America. Infection with RVFV causes mortality in >90% of young domestic ungulates (e. g., calves, kids, and lambs), as well as causing a febrile illness and occasional deaths in humans. Therefore, we evaluated Ae. j. japonicus captured in North Carolina and in Maryland for their ability to serve as potential vectors for RVFV. After feeding on infected adult hamsters, these mosquitoes were tested for infection, dissemination, and the ability to transmit RVFV after incubation at 26 degrees C for 7-28 days. Both the Maryland and North Carolina populations of Ae. j. japonicus were highly efficient laboratory vectors of RVFV, with infection rates >90% and dissemination rates >84% for those mosquitoes that fed on hamsters with viremias >= 10(8.5) plaque-forming units/ml. Thus, Ae. j. japonicus should be targeted for immediate control should RVFV be introduced into an area where this mosquito is now present. C1 [Turell, M. J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Byrd, B. D.; Harrison, B. A.] Western Carolina Univ, Coll Hlth & Human Sci, Cullowhee, NC 28723 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. FU US Department of Homeland Security Science and Technology Directorate [HSHQDC-11-X-00326] FX This work was supported by a grant HSHQDC-11-X-00326 from the US Department of Homeland Security Science and Technology Directorate. NR 44 TC 16 Z9 16 U1 0 U2 16 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2013 VL 29 IS 2 BP 133 EP 137 DI 10.2987/12-6316r.1 PG 5 WC Entomology SC Entomology GA 161DI UT WOS:000320171500006 PM 23923327 ER PT J AU Currano, LJ Becker, CR Lunking, D Smith, GL Isaacson, B Thomas, L AF Currano, Luke J. Becker, Collin R. Lunking, David Smith, Gabriel L. Isaacson, Brian Thomas, Larry TI Triaxial inertial switch with multiple thresholds and resistive ladder readout SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE Shock sensor; Acceleration switch; Accelerometer; Threshold; Inertial switch; g-Switch; Archimedes spiral; Spring ID ELECTROPLATING TECHNOLOGY; ACCELEROMETER ARRAY; FABRICATION; CIRCUIT; SILICON AB We describe the design, modeling, fabrication, and testing of a MEMS inertial switch that can detect accelerations in the x, y, and z axes using a single mass/spring assembly (first reported in Ref. [1]). A spiral spring suspension is used which is compliant in all directions. The inertial switch approach offers zero power draw until an acceleration event occurs. Arrays of individual triaxial sensors are created on a single chip, with each switch designed to close at a different acceleration threshold between 50 g and 250g. A resistor ladder connects each switch together in series such that the number of pinouts from the chip is substantially reduced. The response of the switch array to half-sine acceleration pulses of 5-8 ms duration is reported, with multiple switches in the array closing and opening in sequence for higher magnitude acceleration pulses. The switch closure time under these conditions is consistently less than 200 ps, and bounce is minimal for applied accelerations lower than 200g. Published by Elsevier B.V. C1 [Currano, Luke J.; Becker, Collin R.; Smith, Gabriel L.] USA, Res Lab, Adelphi, MD 20783 USA. [Lunking, David; Isaacson, Brian] Gen Tech Serv ARL, Adelphi, MD 20783 USA. RP Currano, LJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM lcurrano@arl.army.mil FU U.S. Army PM Solider Protection and Individual Equipment FX The authors would like to acknowledge partial funding support for this work from U.S. Army PM Solider Protection and Individual Equipment, and specifically Mr. Karl Masters and Ms. Chris Perritt for their guidance and support toward the eventual Traumatic Brain Injury monitoring application. NR 23 TC 5 Z9 7 U1 1 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD JUN 1 PY 2013 VL 195 BP 191 EP 197 DI 10.1016/j.sna.2012.06.029 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 160UC UT WOS:000320145000028 ER PT J AU Kim, S Zhang, X Daugherty, R Lee, E Kunnen, G Allee, DR Forsythe, E Chae, J AF Kim, S. Zhang, X. Daugherty, R. Lee, E. Kunnen, G. Allee, D. R. Forsythe, E. Chae, J. TI Design and implementation of electrostatic micro-actuators in ultrasonic frequency on a flexible substrate, PEN (polyethylene naphthalate) SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE Ultrasonic actuator; MEMS actuator; Electrostatic actuator ID TRANSDUCERS; PERFORMANCE; TECHNOLOGY AB We present an electrostatic actuator fabricated on a flexible polyethylene naphthalate (PEN) substrate, which emits acoustic waves at ultrasonic frequencies. The MEMS actuator has a suspended parylene diaphragm which consists of 2-6 mm diameter and 6 mu m gap between the diaphragm and substrate. Driving circuitry consists of voltage controlled oscillator (VCO) and output buffer chain, and was fabricated by Arizona State University's Flexible Display Center-IC process. The fabricated actuator emits ultrasonic waves at 25 kHz, and acoustic sound pressure of 27 dB SPL (sound pressure level) driven by the hydrogenated amorphous silicon (a-Si:H) circuitry. (C) 2012 Elsevier B.V. All rights reserved. C1 [Kim, S.; Zhang, X.; Daugherty, R.; Lee, E.; Kunnen, G.; Allee, D. R.; Chae, J.] Arizona State Univ, Dept Elect Comp & Energy Engn, Tempe, AZ 85287 USA. [Forsythe, E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Kim, S (reprint author), Arizona State Univ, Dept Elect Comp & Energy Engn, 650 E Tyler Mall, Tempe, AZ 85287 USA. EM skim85@asu.edu FU Army Research Laboratory [W911NG-04-2-0005] FX The authors thank CSSER (Center for Solid-State Electronics Research) staff at Arizona State University. This work was supported by Army Research Laboratory under Cooperative Agreement W911NG-04-2-0005. NR 26 TC 3 Z9 3 U1 0 U2 14 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD JUN 1 PY 2013 VL 195 BP 198 EP 205 DI 10.1016/j.sna.2012.10.010 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 160UC UT WOS:000320145000029 ER PT J AU Cliver, EW Richardson, IG Ling, AG AF Cliver, E. W. Richardson, I. G. Ling, A. G. TI Solar Drivers of 11-yr and Long-Term Cosmic Ray Modulation SO SPACE SCIENCE REVIEWS LA English DT Review DE Sun; Solar Cycle; Solar Wind; Coronal Mass Ejections; High-speed Streams; Galactic Cosmic Rays; Cosmic Ray Modulation ID CORONAL MASS EJECTIONS; HELIOSPHERIC CURRENT SHEET; DEPENDENT DRIFT MODEL; MERGED INTERACTION REGIONS; NONAXISYMMETRIC OPEN FLUX; WIND MAGNETIC-FIELD; VOYAGER-2 OBSERVATIONS; GEOMAGNETIC-ACTIVITY; PARTICLE DRIFT; TILT ANGLE AB In the current paradigm for the modulation of galactic cosmic rays (GCRs), diffusion is taken to be the dominant process during solar maxima while drift dominates at minima. Observations during the recent solar minimum challenge the pre-eminence of drift at such times. In 2009, the similar to 2 GV GCR intensity measured by the Newark neutron monitor increased by similar to 5% relative to its maximum value two cycles earlier even though the average tilt angle in 2009 was slightly larger than that in 1986 (similar to 20A degrees vs. similar to 14A degrees), while solar wind B was significantly lower (similar to 3.9 nT vs. similar to 5.4 nT). A decomposition of the solar wind into high-speed streams, slow solar wind, and coronal mass ejections (CMEs; including post-shock flows) reveals that the Sun transmits its message of changing magnetic field (diffusion coefficient) to the heliosphere primarily through CMEs at solar maximum and high-speed streams at solar minimum. Long-term reconstructions of solar wind B are in general agreement for the similar to 1900-present interval and can be used to reliably estimate GCR intensity over this period. For earlier epochs, however, a recent Be-10-based reconstruction covering the past similar to 10(4) years shows nine abrupt and relatively short-lived drops of B to a parts per thousand(2)0 nT, with the first of these corresponding to the Sporer minimum. Such dips are at variance with the recent suggestion that B has a minimum or floor value of similar to 2.8 nT. A floor in solar wind B implies a ceiling in the GCR intensity (a permanent modulation of the local interstellar spectrum) at a given energy/rigidity. The 30-40% increase in the intensity of 2.5 GV electrons observed by Ulysses during the recent solar minimum raises an interesting paradox that will need to be resolved. C1 [Cliver, E. W.] USA, Space Vehicles Directorate, Res Lab, Hanscom Afb, MA USA. [Richardson, I. G.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Richardson, I. G.] Univ Maryland, Dept Astron, CRESST, College Pk, MD 20742 USA. [Ling, A. G.] Atmospher & Environm Res Inc, Lexington, MA USA. RP Cliver, EW (reprint author), USA, Space Vehicles Directorate, Res Lab, Hanscom Afb, MA USA. EM afrl.rvb.pa@hanscom.af.mil OI Richardson, Ian/0000-0002-3855-3634 FU AFRL [FA8718-05-C-0036] FX It is a pleasure to thank Jurg Beer, Bernd Heber, Randy Jokipii, Jozsef Kota, Frank McDonald, Harm Moraal, and Rudolf von Steiger for organizing this timely and stimulating workshop. In addition, we are grateful to Marius Potgieter for constructive criticism. A.G.L. acknowledges support from AFRL contract FA8718-05-C-0036. NR 75 TC 22 Z9 22 U1 0 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0038-6308 J9 SPACE SCI REV JI Space Sci. Rev. PD JUN PY 2013 VL 176 IS 1-4 BP 3 EP 19 DI 10.1007/s11214-011-9746-3 PG 17 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 163ZX UT WOS:000320379200002 ER PT J AU Zhang, P Gao, XG Ishida, H Amnuaysirikul, J Weina, PJ Grogl, M O'Neil, MT Li, QG Caridha, D Ohrt, C Hickman, M Magill, AJ Ray, P AF Zhang, Peng Gao, Xiugong Ishida, Hiroshi Amnuaysirikul, Jack Weina, Peter J. Grogl, Max O'Neil, Michael T. Li, Qigui Caridha, Diana Ohrt, Colin Hickman, Mark Magill, Alan J. Ray, Prabhati TI An In vivo Drug Screening Model Using Glucose-6-Phosphate Dehydrogenase Deficient Mice to Predict the Hemolytic Toxicity of 8-Aminoquinolines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRIMAQUINE; MALARIA; THERAPY AB Anti-malarial 8-aminoquinolines drugs cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDD). Efforts to develop non-hemolytic 8-aminoquinolines have been severely limited caused by the lack of a predictive in vivo animal model of hemolytic potential that would allow screening of candidate compounds. This report describes a G6PDD mouse model with a phenotype closely resembling the G6PDD phenotype found in the African A-type G6PDD human. These G6PDD mice, given different doses of primaquine, which used as a reference hemolytic drug, display a full array of hemolytic anemia parameters, consistently and reproducibly. The hemolytic and therapeutic indexes were generated for evaluation of hemotoxicity of drugs. This model demonstrated a complete hemolytic toxicity response to another known hemolytic antimalarial drug, pamaquine, but no response to non-hemolytic drugs, chloroquine and mefloquine. These results suggest that this model is suitable for evaluation of selected 8-AQ type candidate antimalarial drugs for their hemolytic potential. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. [Zhang, Peng; Gao, Xiugong; Ishida, Hiroshi; Amnuaysirikul, Jack; Weina, Peter J.; Grogl, Max; O'Neil, Michael T.; Li, Qigui; Caridha, Diana; Ohrt, Colin; Hickman, Mark; Magill, Alan J.; Ray, Prabhati] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM peng.zhang@amedd.army.mil; Xiugong.Gao@fda.hhs.gov; hiroshi.ishida@amedd.army.mil; Jack.Amnuaysirikul@us.army.mil; peter.weina@us.army.mil; Max.Grogl@amedd.army.mil; michael.t.oneil@us.army.mil; Qigui.Li@us.army.mil; Diana.Caridha2@us.army.mil; Colin.Ohrt@amedd.army.mil; Mark.Hickman@amedd.army.mil; Alan.Magill@us.army.mil; prabhati.say@us.army.mil RI Weina, Peter/A-2120-2011 FU Military Infectious Diseases Research Program (MIDRP) Award [RQ0031_09_WR]; U.S. Army Medical Research & Materiel Command (USAMRMC); Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD [W81XWH-07-2-0095] FX This study was supported by the Military Infectious Diseases Research Program (MIDRP) Award #RQ0031_09_WR and the U.S. Army Medical Research & Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD, under award number: W81XWH-07-2-0095. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 2 Z9 2 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2013 VL 88 IS 6 BP 1138 EP 1145 DI 10.4269/ajtmh.12-0682 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 158GO UT WOS:000319957700020 PM 23530079 ER PT J AU Trejos, T Koons, R Becker, S Berman, T Buscaglia, J Duecking, M Eckert-Lumsdon, T Ernst, T Hanlon, C Heydon, A Mooney, K Nelson, R Olsson, K Palenik, C Pollock, EC Rudell, D Ryland, S Tarifa, A Valadez, M Weis, P Almirall, J AF Trejos, Tatiana Koons, Robert Becker, Stefan Berman, Ted Buscaglia, JoAnn Duecking, Marc Eckert-Lumsdon, Tiffany Ernst, Troy Hanlon, Christopher Heydon, Alex Mooney, Kim Nelson, Randall Olsson, Kristine Palenik, Christopher Pollock, Edward Chip Rudell, David Ryland, Scott Tarifa, Anamary Valadez, Melissa Weis, Peter Almirall, Jose TI Cross-validation and evaluation of the performance of methods for the elemental analysis of forensic glass by mu-XRF, ICP-MS, and LA-ICP-MS SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Elemental analysis; Forensic; Glass; X-ray fluorescence; ICP-MS; Laser ablation ICP-MS ID PLASMA-MASS-SPECTROMETRY; ATOMIC-EMISSION-SPECTROMETRY; X-RAY-FLUORESCENCE; LASER-ABLATION; QUANTITATIVE-ANALYSIS; SAMPLING STRATEGIES; REFRACTIVE-INDEX; FRAGMENTS; DISCRIMINATION; CLASSIFICATION AB Elemental analysis of glass was conducted by 16 forensic science laboratories, providing a direct comparison between three analytical methods [micro-x-ray fluorescence spectroscopy (mu-XRF), solution analysis using inductively coupled plasma mass spectrometry (ICP-MS), and laser ablation inductively coupled plasma mass spectrometry]. Interlaboratory studies using glass standard reference materials and other glass samples were designed to (a) evaluate the analytical performance between different laboratories using the same method, (b) evaluate the analytical performance of the different methods, (c) evaluate the capabilities of the methods to correctly associate glass that originated from the same source and to correctly discriminate glass samples that do not share the same source, and (d) standardize the methods of analysis and interpretation of results. Reference materials NIST 612, NIST 1831, FGS 1, and FGS 2 were employed to cross-validate these sensitive techniques and to optimize and standardize the analytical protocols. The resulting figures of merit for the ICP-MS methods include repeatability better than 5 % RSD, reproducibility between laboratories better than 10 % RSD, bias better than 10 %, and limits of detection between 0.03 and 9 mu g g(-1) for the majority of the elements monitored. The figures of merit for the mu-XRF methods include repeatability better than 11 % RSD, reproducibility between laboratories after normalization of the data better than 16 % RSD, and limits of detection between 5.8 and 7,400 mu g g(-1). The results from this study also compare the analytical performance of different forensic science laboratories conducting elemental analysis of glass evidence fragments using the three analytical methods. C1 [Trejos, Tatiana; Tarifa, Anamary; Almirall, Jose] Florida Int Univ, Int Forens Res Inst, Miami, FL 33199 USA. [Koons, Robert; Buscaglia, JoAnn] Fed Bur Investigat, Lab Div, Counterterrorism & Forens Sci Res Unit, Quantico, VA 22135 USA. [Becker, Stefan; Duecking, Marc; Weis, Peter] Bundeskriminalamt BKA, Forens Sci Inst, D-65173 Wiesbaden, Germany. [Berman, Ted; Ryland, Scott] Orlando Reg Operat Ctr, Florida Dept Law Enforcement, Orlando, FL 32801 USA. [Eckert-Lumsdon, Tiffany; Mooney, Kim] USA, Criminal Investigat Lab, Forest Pk, GA 30297 USA. [Ernst, Troy] Michigan State Police Grand Rapids Lab, Grand Rapids, MI 49503 USA. [Hanlon, Christopher] Forens Sci Serv Bur, Miami Dade Police Dept, Miami, FL 33172 USA. [Heydon, Alex; Rudell, David] Ctr Forens Sci, Toronto, ON M7A 268, Canada. [Nelson, Randall] Tennessee Bur Invest, Forens Serv Div, Nashville, TN 37216 USA. [Olsson, Kristine] Johnson Cty Sheriffs Off Crime Lab, Sunset Olathe, KS 66061 USA. [Palenik, Christopher] Microtrace LLC, Elgin, IL 60123 USA. [Pollock, Edward Chip] Lab Forens Serv, Sacramento Cty Dist Attorneys Off, Sacramento, CA 95820 USA. [Valadez, Melissa] Texas Dept, Publ Safety Crime Lab, Austin, TX 78752 USA. [Almirall, Jose] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. RP Almirall, J (reprint author), Florida Int Univ, Dept Chem & Biochem, OE116 11200 SW 8th St, Miami, FL 33199 USA. EM almirall@fiu.edu RI Almirall, Jose/D-1280-2010 OI Almirall, Jose/0000-0002-5257-7499 FU National Institute of Justice, Office of Justice Programs, U.S. Department of Justice [2010-DN-BX-K179] FX This project was supported by Award No. 2010-DN-BX-K179 from the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. The opinions, findings, and conclusions or recommendations expressed in this presentation are those of the authors and do not necessarily reflect those of the Department of Justice, the Department of the Army or the Department of Defense. Thanks to all of the Elemental Analysis Working Group members and their agencies for devoting the time necessary to complete this project. This is publication number 12-14 of the FBI Laboratory Division. Names of commercial manufacturers are provided for identification purposes only, and inclusion does not imply endorsement of the manufacturer, or its products or services by the FBI. The views expressed are those of the authors and do not necessarily reflect the official policy or position of the FBI or the U.S. Government. NR 54 TC 9 Z9 9 U1 8 U2 58 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUN PY 2013 VL 405 IS 16 BP 5393 EP 5409 DI 10.1007/s00216-013-6978-y PG 17 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 155KD UT WOS:000319745700005 PM 23673570 ER PT J AU Kuhn, JH Bao, YM Bavari, S Becker, S Bradfute, S Brister, JR Bukreyev, AA Cai, YY Chandran, K Davey, RA Dolnik, O Dye, JM Enterlein, S Gonzalez, JP Formenty, P Freiberg, AN Hensley, LE Honko, AN Ignatyev, GM Jahrling, PB Johnson, KM Klenk, HD Kobinger, G Lackemeyer, MG Leroy, EM Lever, MS Lofts, LL Muhlberger, E Netesov, SV Olinger, GG Palacios, G Patterson, JL Paweska, JT Pitt, L Radoshitzky, SR Ryabchikova, EI Saphire, EO Shestopalov, AM Smither, SJ Sullivan, NJ Swanepoel, R Takada, A Towner, JS van der Groen, G Volchkov, VE Wahl-Jensen, V Warren, TK Warfield, KL Weidmann, M Nichol, ST AF Kuhn, Jens H. Bao, Yiming Bavari, Sina Becker, Stephan Bradfute, Steven Brister, J. Rodney Bukreyev, Alexander A. Cai, Yingyun Chandran, Kartik Davey, Robert A. Dolnik, Olga Dye, John M. Enterlein, Sven Gonzalez, Jean-Paul Formenty, Pierre Freiberg, Alexander N. Hensley, Lisa E. Honko, Anna N. Ignatyev, Georgy M. Jahrling, Peter B. Johnson, Karl M. Klenk, Hans-Dieter Kobinger, Gary Lackemeyer, Matthew G. Leroy, Eric M. Lever, Mark S. Lofts, Loreen L. Muehlberger, Elke Netesov, Sergey V. Olinger, Gene G. Palacios, Gustavo Patterson, Jean L. Paweska, Janusz T. Pitt, Louise Radoshitzky, Sheli R. Ryabchikova, Elena I. Saphire, Erica Ollmann Shestopalov, Aleksandr M. Smither, Sophie J. Sullivan, Nancy J. Swanepoel, Robert Takada, Ayato Towner, Jonathan S. van der Groen, Guido Volchkov, Viktor E. Wahl-Jensen, Victoria Warren, Travis K. Warfield, Kelly L. Weidmann, Manfred Nichol, Stuart T. TI Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae SO ARCHIVES OF VIROLOGY LA English DT Article ID VERVET MONKEY DISEASE; MARBURG VIRUS; EBOLA-VIRUS; RHABDOVIRUS-SIMIAE; HEMORRHAGIC-FEVER; MOUSE MODEL; GUINEA-PIGS; VERO CELLS; INFECTION; AGENT AB The International Committee on Taxonomy of Viruses (ICTV) organizes the classification of viruses into taxa, but is not responsible for the nomenclature for taxa members. International experts groups, such as the ICTV Study Groups, recommend the classification and naming of viruses and their strains, variants, and isolates. The ICTV Filoviridae Study Group has recently introduced an updated classification and nomenclature for filoviruses. Subsequently, and together with numerous other filovirus experts, a consistent nomenclature for their natural genetic variants and isolates was developed that aims at simplifying the retrieval of sequence data from electronic databases. This is a first important step toward a viral genome annotation standard as sought by the US National Center for Biotechnology Information (NCBI). Here, this work is extended to include filoviruses obtained in the laboratory by artificial selection through passage in laboratory hosts. The previously developed template for natural filovirus genetic variant naming (< virus name > < isolation host-suffix >/< country of sampling >/< year of sampling >/< genetic variant designation >-< isolate designation >) is retained, but it is proposed to adapt the type of information added to each field for laboratory animal-adapted variants. For instance, the full-length designation of an Ebola virus Mayinga variant adapted at the State Research Center for Virology and Biotechnology "Vector" to cause disease in guinea pigs after seven passages would be akin to "Ebola virus VECTOR/C.porcellus-lab/COD/1976/Mayinga-GPA-P7". As was proposed for the names of natural filovirus variants, we suggest using the full-length designation in databases, as well as in the method section of publications. Shortened designations (such as "EBOV VECTOR/C.por/COD/76/May-GPA-P7") and abbreviations (such as "EBOV/May-GPA-P7") could be used in the remainder of the text depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed. C1 [Kuhn, Jens H.; Cai, Yingyun; Jahrling, Peter B.; Lackemeyer, Matthew G.; Wahl-Jensen, Victoria] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, Frederick, MD 21702 USA. [Bao, Yiming; Brister, J. Rodney] Natl Lib Med, Informat Engn Branch, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. [Bavari, Sina; Dye, John M.; Honko, Anna N.; Lofts, Loreen L.; Olinger, Gene G.; Palacios, Gustavo; Pitt, Louise; Radoshitzky, Sheli R.; Warren, Travis K.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Becker, Stephan; Dolnik, Olga; Klenk, Hans-Dieter] Univ Marburg, Inst Virol, D-35032 Marburg, Germany. [Bradfute, Steven] Univ New Mexico, Albuquerque, NM 87131 USA. [Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Davey, Robert A.; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA. [Enterlein, Sven; Warfield, Kelly L.] Integrated BioTherapeut Inc, Gaithersburg, MD USA. [Gonzalez, Jean-Paul] Inst Rech Dev, Dept Hlth, Marseille, France. [Gonzalez, Jean-Paul] Metabiota Inc, San Francisco, CA USA. [Formenty, Pierre] World Hlth Org, Geneva, Switzerland. [Hensley, Lisa E.] US FDA, Med Countermeasure Initiat, Silver Spring, MD USA. [Ignatyev, Georgy M.] Fed State Unitary Co Microgen Sci Ind Co Immunobi, Minist Hlth & Social Dept Russian Federat, Moscow, Russia. [Kobinger, Gary] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB, Canada. [Leroy, Eric M.] Ctr Int Rech Med Franceville, Franceville, Gabon. [Lever, Mark S.; Smither, Sophie J.] Dstl, Dept Biomed Sci, Salisbury, Wilts, England. [Muehlberger, Elke] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Muehlberger, Elke] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA. [Netesov, Sergey V.; Shestopalov, Aleksandr M.] Novosibirsk State Univ, Novosibirsk, Novosibirsk Obl, Russia. [Paweska, Janusz T.] Natl Hlth Lab Serv, Ctr Emerging & Zoonot Dis, Natl Inst Communicable Dis, Sandringham Johannesburg, Gauteng, South Africa. [Ryabchikova, Elena I.] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk, Novosibirsk Obl, Russia. [Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Shestopalov, Aleksandr M.] State Res Ctr Virol & Biotechnol Vector, Koltsov, Novosibirsk Obl, Russia. [Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0002 Pretoria, South Africa. [Takada, Ayato] Hokkaido Univ, Div Global Epidemiol, Res Ctr Zoonosis Control, Sapporo, Hokkaido, Japan. [Towner, Jonathan S.; Nichol, Stuart T.] Ctr Dis Control & Prevent CDC, VSPB, DHCPP, NCEZID, Atlanta, GA 30333 USA. [van der Groen, Guido] Prins Leopold Inst Trop Geneeskunde, Antwerp, Belgium. [Volchkov, Viktor E.] Univ Lyon, Lab Filovirus, Inserm U758, UCB Lyon 1,Ecole Normale Super Lyon, Lyon, France. [Weidmann, Manfred] Univ Med Gottingen, Abt Virol, Gottingen, Germany. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov; stn1@cdc.gov RI Ryabchikova, Elena /G-3089-2013; LEROY, Eric/I-4347-2016; Netesov, Sergey/A-3751-2013; Volchkov, Viktor/M-7846-2014; Kuhn, Jens H./B-7615-2011; Becker, Stephan/A-1065-2010; Palacios, Gustavo/I-7773-2015; Weidmann, Manfred/G-1817-2015; OI Gonzalez, Jean-Paul/0000-0003-3063-1770; Muhlberger, Elke/0000-0003-3547-9376; Honko, Anna/0000-0001-9165-148X; Ryabchikova, Elena /0000-0003-4714-1524; LEROY, Eric/0000-0003-0022-0890; Netesov, Sergey/0000-0002-7786-2464; Volchkov, Viktor/0000-0001-7896-8706; Kuhn, Jens H./0000-0002-7800-6045; Becker, Stephan/0000-0002-2794-5659; Palacios, Gustavo/0000-0001-5062-1938; Weidmann, Manfred/0000-0002-7063-7491; Shestopalov, Alexander/0000-0002-9734-0620; Olinger, Gene/0000-0001-7338-0292 FU Joint Science and Technology Office for Chem Bio Defense [TMTI0048_09_RD_T]; NIAID [HHSN272200200016I]; Intramural Research Program of the NIH, National Library of Medicine FX The content of this publication does not necessarily reflect the views or policies of the US Department of the Army, the US Department of Defense or the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. This work was funded in part by the Joint Science and Technology Office for Chem Bio Defense (proposal #TMTI0048_09_RD_T to SB). YC, JHK, and VWJ performed this work as employees of Tunnell Consulting, Inc., and MGL as an employee of Lovelace Respiratory Research Institute, both subcontractors to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200200016I. This research was also supported in part by the Intramural Research Program of the NIH, National Library of Medicine (YB and JRB). NR 42 TC 20 Z9 21 U1 0 U2 23 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD JUN PY 2013 VL 158 IS 6 BP 1425 EP 1432 DI 10.1007/s00705-012-1594-2 PG 8 WC Virology SC Virology GA 155QK UT WOS:000319762800035 PM 23358612 ER PT J AU Yee, SB Dyer, DN Twenhafel, NA Pitt, MLM AF Yee, Steven B. Dyer, David N. Twenhafel, Nancy A. Pitt, M. Louise M. TI Transient Lipopolysaccharide-Induced Resistance to Aerosolized Bacillus anthracis in New Zealand White Rabbits SO COMPARATIVE MEDICINE LA English DT Article ID AFRICAN-GREEN MONKEY; INHALATIONAL ANTHRAX; BACTERIAL-INFECTION; PROTECTIVE ANTIGEN; CYTOKINE RESPONSE; INNATE IMMUNITY; ANIMAL-MODELS; MICE; ENDOTOXIN; SPORES AB Previous studies have demonstrated that prior infection by various bacterial pathogens induces nonspecific resistance to subsequent infection by other gram-negative and gram-positive bacterial pathogens. In the present study, we evaluated whether underlying inflammation enhanced host resistance to inhalational Bacillus anthracis infection in New Zealand White rabbits (SPF; Bordetella- and Pasteurella-free). Accordingly, rabbits were pretreated with either the inflammagen bacterial LPS (60,000 EU/kg), a component of the outer membrane of gram-negative bacteria, or saline (vehicle). Administration of LPS resulted in brief pyrexia and a significant increase in the proinflammatory cytokine TNF alpha, thus confirming LPS-induced inflammation. At 24 h after LPS treatment, rabbits were exposed to aerosolized B. anthracis spores (Ames strain; approximately 300 LD50). Blood samples collected at various times after challenge were cultured. Compared with their saline-pretreated counterparts, LPS-pretreated, B. anthracis-challenged rabbits exhibited delays in 2 biomarkers of B. anthracis infection anthrax-induced pyrexia (25 h versus 66 h after challenge, respectively) and bacteremia (26 h versus 63 h, respectively)-and survived longer (41 h versus 90 h, respectively). Similar to control animals, all LPS-pretreated, B. anthracis-challenged rabbits exhibited pathology consistent with inhalational anthrax. Taken together, these results suggest that prior or underlying stimulation of the innate immune system induces transient host resistance to subsequent B. anthracis infection in SPF New Zealand white rabbits. In particular, our results emphasize the importance of using animals that are free of underlying infections to prevent confounding data in studies for inhalational anthrax characterization and medical countermeasure evaluation. C1 [Yee, Steven B.; Dyer, David N.; Pitt, M. Louise M.] USA, Med Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA. [Twenhafel, Nancy A.] USA, Med Inst Infect Dis, Div Pathol, Ft Detrick, MD USA. RP Yee, SB (reprint author), USA, Med Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA. EM steven.yee@us.army.mil FU National Institute of Allergy and Infectious Diseases [Y1-AI-6129-04]; United States Army Medical Research Institute of Infectious Diseases (USAMRIID) [A 120-B-10.3] FX This research was sponsored through an interagency agreement between the National Institute of Allergy and Infectious Diseases (Y1-AI-6129-04), and the United States Army Medical Research Institute of Infectious Diseases (USAMRIID; A 120-B-10.3). The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of Army position, policy, or decision unless so designated by other documentation. The authors do not have a commercial or other association that would pose a conflict of interest. NR 67 TC 0 Z9 0 U1 1 U2 5 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD JUN PY 2013 VL 63 IS 3 BP 252 EP 261 PG 10 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 162WP UT WOS:000320297000009 PM 23759528 ER PT J AU Basu, P Gibbens, R La Porta, T Lin, CY Swami, A Yoneki, E AF Basu, Prithwish Gibbens, Richard La Porta, Thomas Lin, Ching-Yung Swami, Ananthram Yoneki, Eiko TI Network Science SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Editorial Material C1 [Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA USA. [Gibbens, Richard] Univ Cambridge, Comp Lab, Cambridge CB2 3QG, England. [La Porta, Thomas] Penn State Univ, State Coll, PA USA. [Lin, Ching-Yung] IBM Res, Yorktown Hts, NY USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD USA. [Yoneki, Eiko] Univ Cambridge, Comp Lab, Syst Res Grp, Cambridge CB2 3QG, England. RP Basu, P (reprint author), Raytheon BBN Technol, Cambridge, MA USA. NR 0 TC 2 Z9 2 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD JUN PY 2013 VL 31 IS 6 BP 993 EP 996 DI 10.1109/JSAC.2013.130601 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 149XE UT WOS:000319353900001 ER PT J AU Wang, D Kaplan, L Abdelzaher, T Aggarwal, CC AF Wang, Dong Kaplan, Lance Abdelzaher, Tarek Aggarwal, Charu C. TI On Credibility Estimation Tradeoffs in Assured Social Sensing SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Maximum Likelihood Estimation; Predictability; Cramer-Rao Lower Bound; Scalability; Robustness; Truth Discovery; Social Sensing AB Two goals of network science are to (i) uncover fundamental properties of phenomena modeled as networks, and to (ii) explore novel use of networks as models for a diverse range of systems and phenomena in order to improve our understanding of such systems and phenomena. This paper advances the latter direction by casting credibility estimation in social sensing applications as a network science problem, and by presenting a network model that helps understand the fundamental accuracy trade-offs of a credibility estimator. Social sensing refers to data collection scenarios, where observations are collected from (possibly unvetted) human sources. We call such observations claims to emphasize that we do not know whether or not they are factually correct. Predictable, scalable and robust estimation of both source reliability and claim correctness, given neither in advance, becomes a key challenge given the unvetted nature of sources and lack of means to verify their claims. In a previous conference publication, we proposed a maximum likelihood approach to jointly estimate both source reliability and claim correctness. We also derived confidence bounds to quantify the accuracy of such estimation. In this paper, we cast credibility estimation as a network science problem and offer systematic sensitivity analysis of the optimal estimator to understand its fundamental accuracy trade-offs as a function of an underlying network topology that describes key problem space parameters. It enables assured social sensing, where not only source reliability and claim correctness are estimated, but also the accuracy of such estimates is correctly predicted for the problem at hand. C1 [Wang, Dong; Abdelzaher, Tarek] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA. [Kaplan, Lance] USA, Networked Sensing & Fus Branch, Res Lab, Adelphi, MD 20783 USA. [Aggarwal, Charu C.] IBM Res, Yorktown Hts, NY 10598 USA. RP Wang, D (reprint author), Univ Illinois, Dept Comp Sci, 1304 W Springfield Ave, Urbana, IL 61801 USA. EM dwang24@illinois.edu; lance.m.kaplan@us.army.mil; za-her@illinois.edu; charu@us.ibm.com FU Army Research Laboratory, DTRA grant [HDTRA1-10-1-0120]; NSF [CNS 1040380, CNS 09-05014] FX Research reported in this paper was sponsored by the Army Research Laboratory, DTRA grant HDTRA1-10-1-0120, and NSF grants CNS 1040380 and CNS 09-05014, and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 22 TC 16 Z9 16 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD JUN PY 2013 VL 31 IS 6 BP 1026 EP 1037 DI 10.1109/JSAC.2013.130605 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 149XE UT WOS:000319353900005 ER PT J AU Li, L Scaglione, A Swami, A Zhao, Q AF Li, Lin Scaglione, Anna Swami, Ananthram Zhao, Qing TI Consensus, Polarization and Clustering of Opinions in Social Networks SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE opinion dynamics; continuous opinions; opinion clusters; consensus; polarization; opinion formation; social networks; opinion diffusion; information aggregation; network learning; non-Bayesian models; information aggregation AB We consider a variation of the Deffuant-Weisbuch model introduced by Deffuant et al. in 2000, to provide new analytical insights on the opinion dynamics in a social group. We model the trust that may exist between like-minded agents through a trust function, which is a discontinuous (hard-interaction) non-increasing function of the opinion distance. In this model, agents exchange their opinions with their neighbors and move their opinions closer to each other if they are like-minded (that is, the distance between opinions is smaller than a threshold). We first study the dynamics of opinion formation under random interactions with a fixed rate of communication between pairs of agents. Our goal is to analyze the convergence properties of the opinion dynamics and explore the underlying characteristics that mark the phase transition from opinion polarization to consensus. Furthermore, we extend the hard-interaction model to a strategic interaction model by considering a time-varying rate of interaction. In this model, social agents themselves decide the time and energy that should be expended on interacting each of their neighbors, based on their utility functions. The aim is to understand how and under what conditions clustering patterns emerge in opinion space. Extensive simulations are provided to validate the analytical results of both the hard-interaction model and the strategic interaction model. We also offer evidence that suggests the validity of the proposed model, using the location and monthly survey data collected in the Social Evolution experiment over a period of nine months. C1 [Li, Lin; Scaglione, Anna; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Li, L (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM llli@ucdavis.edu; ascaglione@ucdavis.edu; ananthram.swami.civ@mail.mil; qzhao@ucdavis.edu FU NSF [CCF-1011811] FX The first two authors of this work were supported by NSF grant CCF-1011811. NR 27 TC 9 Z9 9 U1 1 U2 23 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 EI 1558-0008 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD JUN PY 2013 VL 31 IS 6 BP 1072 EP 1083 DI 10.1109/JSAC.2013.130609 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 149XE UT WOS:000319353900009 ER PT J AU Boonnak, K Slike, BM Donofrio, GC Marovich, MA AF Boonnak, Kobporn Slike, Bonnie M. Donofrio, Gina C. Marovich, Mary A. TI Human Fc gamma RII Cytoplasmic Domains Differentially Influence Antibody-Mediated Dengue Virus Infection SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IGG-FC; DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; DENDRITIC CELLS; RECEPTORS; REGULATORS AB Ab-dependent enhancement (ADE) of dengue virus (DENY) infection is mediated through the interaction of viral immune complexes with Fc gamma Rs, with notable efficiency of Fc gamma RII. Most human dengue target cells coexpress activating (Fc gamma RIIa) and inhibitory (Fc gamma RIIb) isoforms, but their relative roles in ADE are not well understood. We studied the effects of Fc gamma RIIa and Fc gamma RIIb by transfecting cells to express each individual receptor isoform or through coexpression of both isoforms. We showed that although both isoforms similarly bind dengue-immune complexes, Fc gamma RIIa efficiently internalized virus leading to productive cellular infection, unlike Fc gamma RIIb. We next focused on the main discriminating feature of these isoforms: their distinct intra-cytoplasmic tails (Fcy gamma IIa with an immunoreceptor tyrosine-based activation motif [ITAM] and Fc gamma RIIb with an immunoreceptor tyrosine-based inhibitory motif [ITIM]). We engineered cells to express "swapped" versions of their Fc gamma RII by switching the cytoplasmic tails containing the ITAM/ITIM motifs, leaving the remainder of the receptor intact. Our data show that both Fc gamma RIIa and Fc gamma RIIb comparably bind dengue immune complexes. However, wild type Fc gamma RIIa facilitates DENY entry by virtue of the ITAM motif, whereas the swapped version Fc gamma RIIa-ITIM significantly inhibited ADE. Similarly, replacing the inhibitory motif in Fc gamma RIIb with an ITAM (Fc gamma RIIb-ITAM) reconstituted ADE capacity to levels of the wild type activating counterpart, Fc gamma RIIa. Our data suggest that Fc gamma RIIa and Fc gamma RIIb isoforms, as the most abundantly distributed class II Fc gamma receptors, differentially influence Ab-mediated DENY infection under ADE conditions both at the level of cellular infection and viral production. C1 [Boonnak, Kobporn; Slike, Bonnie M.; Donofrio, Gina C.; Marovich, Mary A.] Henry M Jackson Fdn Adv Mil Med, Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Marovich, Mary A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Marovich, MA (reprint author), NIAID, Vaccine Res Program, Div AIDS, NIH, 6700-B Rockledge Room 5142, Bethesda, MD 20892 USA. EM mary.marovich@nih.gov FU Pediatric Dengue Vaccine Initiative; Henry M. Jackson Foundation for the Advancement of Military Medicine; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported by the Pediatric Dengue Vaccine Initiative and in part by the cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, and the U.S. Department of Defense. NR 31 TC 24 Z9 26 U1 1 U2 5 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUN 1 PY 2013 VL 190 IS 11 BP 5659 EP 5665 DI 10.4049/j.immunol.1203052 PG 7 WC Immunology SC Immunology GA 147XY UT WOS:000319205900036 PM 23616574 ER PT J AU Beyaz, MI Hanrahan, BM Feldman, J Ghodssi, R AF Beyaz, Mustafa Ilker Hanrahan, Brendan Michael Feldman, Jeremy Ghodssi, Reza TI An Integrated Permanent-Magnet Microturbogenerator Supported on Microball Bearings SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Microball bearings; microgenerator; microturbogenerator; power microelectromechanical systems (MEMS) ID AXIAL-FLUX; POWER-GENERATION; DESIGN; FABRICATION; MICROSCALE; MACHINES AB This paper presents the design, fabrication, and testing of an integrated microturbogenerator utilizing permanent magnets and microball bearings. The key components of this generator are the following: 1) a silicon microturbine rotor housing thick magnetic components; 2) encapsulated microball bearings providing a simple actuation scheme and a robust support structure; and 3) wafer-thick stator coils. The microturbogenerator was designed and fabricated to have a ten-pole rotor and a ten-pole three-turns-per-pole stator. The impedance of the stator coils was shown to be a purely resistive 220 Omega up to 10 kHz. The spin-down characterization of the rotor revealed a dynamic friction torque of 33 mu N . m at a rotational speed of 16 kilo rotations per minute (krpm), corresponding to 6% turbine efficiency. The maximum per-phase ac open-circuit voltage and power were measured to be 0.1 V and 5.6 mu W on a matched load at 23 krpm, respectively, in full agreement with theoretical analysis and performance estimations. The microturbogenerator presented in this paper provides a flexible design platform for further improvement and will lead to the development of next-generation integrated microturbogenerators offering high power, simple operation, and robust mechanics. [2012-0186] C1 [Beyaz, Mustafa Ilker; Hanrahan, Brendan Michael; Feldman, Jeremy; Ghodssi, Reza] Univ Maryland, College Pk, MD 20742 USA. [Hanrahan, Brendan Michael] USA, Res Lab, Adelphi, MD 20783 USA. [Beyaz, Mustafa Ilker] Antalya Int Univ, TR-07190 Antalya, Turkey. RP Beyaz, MI (reprint author), Antalya Int Univ, TR-07190 Antalya, Turkey. EM mibeyaz@antalya.edu.tr; bhanrah@gmail.com; jfn@umd.edu; ghodssi@umd.edu FU U.S. National Science Foundation [0901411] FX This work was supported by the U.S. National Science Foundation under Award 0901411. Subject Editor L. Spangler. NR 22 TC 3 Z9 4 U1 0 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD JUN PY 2013 VL 22 IS 3 BP 794 EP 803 DI 10.1109/JMEMS.2013.2245401 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 156MZ UT WOS:000319827700031 ER PT J AU Marathe, AR Taylor, DM AF Marathe, A. R. Taylor, D. M. TI Decoding continuous limb movements from high-density epidural electrode arrays using custom spatial filters SO JOURNAL OF NEURAL ENGINEERING LA English DT Article ID BRAIN-COMPUTER-INTERFACE; INDIVIDUAL FINGER MOVEMENTS; SPINAL-CORD-INJURY; CHRONIC STROKE; MOTOR IMAGERY; ELECTROCORTICOGRAPHIC SIGNALS; CORTICAL REPRESENTATION; HAND MOVEMENT; ARM MOVEMENTS; REHABILITATION AB Objective. Our goal was to identify spatial filtering methods that would improve decoding of continuous arm movements from epidural field potentials as well as demonstrate the use of the epidural signals in a closed-loop brain-machine interface (BMI) system in monkeys. Approach. Eleven spatial filtering options were compared offline using field potentials collected from 64-channel high-density epidural arrays in monkeys. Arrays were placed over arm/ hand motor cortex in which intracortical microelectrodes had previously been implanted and removed leaving focal cortical damage but no lasting motor deficits. Spatial filters tested included: no filtering, common average referencing (CAR), principle component analysis, and eight novel modifications of the common spatial pattern (CSP) algorithm. The spatial filtering method and decoder combination that performed the best offline was then used online where monkeys controlled cursor velocity using continuous wrist position decoded from epidural field potentials in real time. Main results. Optimized CSP methods improved continuous wrist position decoding accuracy by 69% over CAR and by 80% compared to no filtering. Kalman decoders performed better than linear regression decoders and benefitted from including more spatially-filtered signals but not from pre-smoothing the calculated power spectra. Conversely, linear regression decoders required fewer spatially-filtered signals and were improved by pre-smoothing the power values. The ` position-to-velocity' transformation used during online control enabled the animals to generate smooth closed-loop movement trajectories using the somewhat limited position information available in the epidural signals. The monkeys' online performance significantly improved across days of closed-loop training. Significance. Most published BMI studies that use electrocorticographic signals to decode continuous limb movements either use no spatial filtering or CAR. This study suggests a substantial improvement in decoding accuracy could be attained by using our new version of the CSP algorithm that extends the traditional CSP method for use with continuous limb movement data. C1 [Marathe, A. R.; Taylor, D. M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA. [Marathe, A. R.; Taylor, D. M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA. [Marathe, A. R.; Taylor, D. M.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH 44106 USA. [Marathe, A. R.] USA, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Marathe, AR (reprint author), Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA. EM dawn.taylor@case.edu FU National Institutes of Health NINDS [1R01NS058871]; Department of Veterans Affairs [B4195R]; Cleveland Clinic, and Case Western Reserve University FX This project was supported by the National Institutes of Health NINDS 1R01NS058871, the Department of Veterans Affairs # B4195R, the Cleveland Clinic, and Case Western Reserve University. NR 91 TC 11 Z9 11 U1 0 U2 12 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1741-2560 EI 1741-2552 J9 J NEURAL ENG JI J. Neural Eng. PD JUN PY 2013 VL 10 IS 3 AR 036015 DI 10.1088/1741-2560/10/3/036015 PG 16 WC Engineering, Biomedical; Neurosciences SC Engineering; Neurosciences & Neurology GA 152DM UT WOS:000319510800018 PM 23611833 ER PT J AU Bourget, EC Langsdale, SM van den Belt, M AF Bourget, Elizabeth C. Langsdale, Stacy M. van den Belt, Marjan TI Featured Collection Introduction: Collaborative Modeling for Decision Support as a Tool to Implement IWRM SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article C1 [Bourget, Elizabeth C.] USA, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. [Langsdale, Stacy M.] USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. [van den Belt, Marjan] Massey Univ, Palmerston North 4442, New Zealand. [van den Belt, Marjan] Massey Univ, Ecol Econ Res New Zealand, Palmerston North 4442, New Zealand. RP Bourget, EC (reprint author), USA, Inst Water Resources, Corps Engineers, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM slangsdale@gmail.com NR 10 TC 3 Z9 3 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2013 VL 49 IS 3 BP 605 EP 608 DI 10.1111/jawr.12071 PG 4 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 157LL UT WOS:000319897500010 ER PT J AU Priscoli, JD AF Priscoli, Jerome Delli TI Keynote Address: Clothing the IWRM Emperor by Using Collaborative Modeling for Decision Support SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article C1 USA, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. RP Priscoli, JD (reprint author), USA, Inst Water Resources, Corps Engineers, Casey Bldg,7701 Telegraph Rd, Alexandria, VA 22315 USA. EM priscoli@erols.com NR 0 TC 2 Z9 2 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2013 VL 49 IS 3 BP 609 EP 613 DI 10.1111/jawr.12072 PG 5 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 157LL UT WOS:000319897500011 ER PT J AU Palmer, RN Cardwell, HE Lorie, MA Werick, W AF Palmer, Richard N. Cardwell, Hal E. Lorie, Mark A. Werick, William TI Disciplined Planning, Structured Participation, and Collaborative Modeling - Applying Shared Vision Planning to Water Resources SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE collaborative planning; collaborative modeling; systems models; water management; water resources planning; adaptive management; participatory methodologies ID DECISION-MAKING; MANAGEMENT; DEMOCRACY; SCIENCE; POLICY AB Participatory planning applied to water resources has sparked significant interest and debate during the last decade. Recognition that models play a significant role in the formulation and implementation of design and management strategies has encouraged the profession to consider how such models can be best implemented. Shared Vision Planning (SVP) is a disciplined planning approach that combines traditional water resources planning methodologies with innovations such as structured public participation and the use of collaborative modeling, resulting in a more complete understanding and an integrative decision support tool. This study reviews these three basic components of SVP and explains how they are incorporated into a unified planning approach. The successful application of SVP is explored in three studies involving planning challenges: the National Drought Study, the Lake Ontario-St. Lawrence River Study, and the Apalachicola-Chattahoochee-Flint/Alabama-Coosa-Tallapoosa River Basin Study. The article concludes by summarizing the advantages and limitations of this planning approach. C1 [Palmer, Richard N.] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Cardwell, Hal E.] USA, Conflict Resolut & Publ Participat Ctr, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. [Lorie, Mark A.] Resolut Planning LLC, Ft Collins, CO 80526 USA. [Werick, William] Werick Creat Solut, Culpeper, VA 22701 USA. RP Palmer, RN (reprint author), Univ Massachusetts, Dept Civil & Environm Engn, 130 Nat Resources Rd, Amherst, MA 01003 USA. EM palmer@esc.umass.edu NR 77 TC 9 Z9 9 U1 0 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2013 VL 49 IS 3 BP 614 EP 628 DI 10.1111/jawr.12067 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 157LL UT WOS:000319897500012 ER PT J AU Langsdale, S Beall, A Bourget, E Hagen, E Kudlas, S Palmer, R Tate, D Werick, W AF Langsdale, Stacy Beall, Allyson Bourget, Elizabeth Hagen, Erik Kudlas, Scott Palmer, Richard Tate, Diane Werick, William TI Collaborative Modeling for Decision Support in Water Resources: Principles and Best Practices SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE collaborative modeling; decision support systems; public participation; planning; participatory modeling; Shared Vision Planning; Mediated Modeling; conflict resolution AB Collaborative Modeling for Decision Support integrates collaborative modeling with participatory processes to inform natural resources decisions. Practitioners and advocates claim that the approach will lead to better water management, balancing interests more effectively and reducing the likelihood of costly legal delays. These claims are easy to make, but the benefits will only be realized if the process is conducted effectively. To provide guidance for how to conduct an effective collaborative modeling process, a task committee cosponsored by the Environmental Water Resources Institute (EWRI) of the American Society of Civil Engineers and by the U.S. Army Corps of Engineers' Institute for Water Resources developed a set of Principles and Best Practices for anyone who might convene or conduct collaborative modeling processes. The guidance is intended for both conflict resolution professionals and modelers, and our goal is to integrate these two fields in a way that will improve water resources planning and decision making. Here, the set of eight principles is presented along with a selection of associated best practices, illustrated by two different case examples. The complete document is available at: http://www.computeraideddisputeresolution.us/bestpractices/. C1 [Langsdale, Stacy] USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. [Beall, Allyson] Washington State Univ, Pullman, WA 99164 USA. [Bourget, Elizabeth] Inst Water Resources, Alexandria, VA 22315 USA. [Hagen, Erik] Northeast Midwest Inst, Houston, TX 77019 USA. [Hagen, Erik] Potamoi LLC, Houston, TX 77019 USA. [Kudlas, Scott] Virginia Dept Environm Qual, Off Water Supply, Richmond, VA 23218 USA. [Palmer, Richard] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Werick, William] Werick Creat Solut Inc, Culpeper, VA 22701 USA. RP Langsdale, S (reprint author), USA, Water Resources Collaborat, Inst Water Resources, Corps Engineers, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM slangsdale@gmail.com RI Palmer, Richard/K-4432-2013 OI Palmer, Richard/0000-0002-7338-0468 NR 15 TC 18 Z9 18 U1 1 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2013 VL 49 IS 3 BP 629 EP 638 DI 10.1111/jawr.12065 PG 10 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 157LL UT WOS:000319897500013 ER PT J AU Kaiser, L Frins, E Hils, B Beresnev, L Dultz, W Schmitzer, H AF Kaiser, Laure Frins, Erna Hils, Bernhard Beresnev, Leonid Dultz, Wolfgang Schmitzer, Heidrun TI Polarization analyzer for all the states of polarization of light using a structured polarizer SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article AB Polarization analyzers are an essential measuring tool to improve the characteristics of optical components and optimize them with respect to a useful application in optical networks. We describe an instrument of this kind, which consists of two crossed birefringent wedges and acts as a continuous structured polarizer for all the states of polarization of light. We analyze this device theoretically by using the Poincare-sphere and the Jones-matrix method and verify our results in a number of experiments with quartz wedges and red filtered light. Different realizations of this instrument are discussed, and an application as a beam splitter for all the states of polarization is proposed. (c) 2013 Optical Society of America C1 [Kaiser, Laure; Schmitzer, Heidrun] Xavier Univ, Cincinnati, OH 45208 USA. [Frins, Erna] Univ Republica, Inst Fis, Montevideo 11300, Uruguay. [Hils, Bernhard; Dultz, Wolfgang] Johann Wolfgang von Goethe Univ, D-60054 Frankfurt, Germany. [Beresnev, Leonid] USA, Res Lab, Columbia, MD 20783 USA. RP Schmitzer, H (reprint author), Xavier Univ, Cincinnati, OH 45208 USA. EM schmitzer@xavier.edu FU Research Corporation for Science Advancement [CC6339]; John Hauck Foundation; PEDECIBA (Uruguay); Comision Sectorial de Investigacion Cientifica (CSIC, UdelaR, Uruguay) FX This project was funded by grant CC6339 from the Research Corporation for Science Advancement and the John Hauck Foundation. E. Frins acknowledges the financial support from PEDECIBA (Uruguay) and the Comision Sectorial de Investigacion Cientifica (CSIC, UdelaR, Uruguay). The authors would like to thank A. Debell for the preparation of the photos. NR 13 TC 0 Z9 0 U1 0 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD JUN PY 2013 VL 30 IS 6 BP 1256 EP 1260 DI 10.1364/JOSAA.30.001256 PG 5 WC Optics SC Optics GA 156DG UT WOS:000319800400023 PM 24323113 ER PT J AU Jackson, WM Alexander, PG Bulken-Hoover, JD Vogler, JA Ji, YM Mckay, P Nesti, LJ Tuan, RS AF Jackson, Wesley M. Alexander, Peter G. Bulken-Hoover, Jamie D. Vogler, Jared A. Ji, Youngmi McKay, Patricia Nesti, Leon J. Tuan, Rocky S. TI Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Article DE mesenchymal stem cells; nerve regeneration; neurotrophic factors; dorsal root ganglia; brain-derived neurotrophic factor ID PERIPHERAL-NERVE REGENERATION; STEM-CELLS; STROMAL CELLS; NEUROTROPHIC FACTORS; CONDITIONED MEDIUM; NEURAL PROTEINS; TISSUE-REPAIR; IN-VITRO; DIFFERENTIATION; EXPRESS AB The success of peripheral nerve regeneration is governed by the rate and quality of axon bridging and myelination that occurs across the damaged region. Neurite growth and the migration of Schwann cells is regulated by neurotrophic factors produced as the nerve regenerates, and these processes can be enhanced by mesenchymal stem cells (MSCs), which also produce neurotrophic factors and other factors that improve functional tissue regeneration. Our laboratory has recently identified a population of mesenchymal progenitor cells (MPCs) that can be harvested from traumatized muscle tissue debrided and collected during orthopaedic reconstructive surgery. The objective of this study was to determine whether the traumatized muscle-derived MPCs exhibit neurotrophic function equivalent to that of bone marrow-derived MSCs. Similar gene- and protein-level expression of specific neurotrophic factors was observed for both cell types, and we localized neurogenic intracellular cell markers (brain-derived neurotrophic factor and nestin) to a subpopulation of both MPCs and MSCs. Furthermore, we demonstrated that the MPC-secreted factors were sufficient to enhance in vitro axon growth and cell migration in a chick embryonic dorsal root ganglia (DRG) model. Finally, DRGs in co-culture with the MPCs appeared to increase their neurotrophic function via soluble factor communication. Our findings suggest that the neurotrophic function of traumatized muscle-derived MPCs is substantially equivalent to that of the well-characterized population of bone marrow-derived MPCs, and suggest that the MPCs may be further developed as a cellular therapy to promote peripheral nerve regeneration. Copyright (c) 2012 John Wiley & Sons, Ltd. C1 [Jackson, Wesley M.; Alexander, Peter G.; Bulken-Hoover, Jamie D.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Jackson, Wesley M.; McKay, Patricia; Nesti, Leon J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Clin & Expt Orthopaed Lab, Bethesda, MD 20814 USA. [Alexander, Peter G.; Tuan, Rocky S.] Univ Pittsburgh, Dept Orthopaed Surg, Sch Med, Ctr Cellular & Mol Engn, Pittsburgh, PA 15219 USA. [Vogler, Jared A.; Ji, Youngmi; Nesti, Leon J.] NIAMSD, Clin & Expt Orthopaed Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Bulken-Hoover, Jamie D.; Vogler, Jared A.; McKay, Patricia; Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), Univ Pittsburgh, Dept Orthopaed Surg, Sch Med, Ctr Cellular & Mol Engn, Room 221,450 Technol Dr, Pittsburgh, PA 15219 USA. EM rst13@pitt.edu FU National Institutes of Health (NIH) [Z01 AR41131]; Department of Defense Military Amputee Research Program at WRAMC (Department of the Army, U.S. Army Medical Research Acquisition Activity) [PO5-A011]; Comprehensive Neurosciences Program (The Uniformed Services University of the Health Sciences (USU) [CNP-2008-CR01]; Peer-reviewed Orthopedic Research Program (Department of the Army, U.S. Army Medical Research Acquisition Activity) [W81XWH-10-2-0084]; Commonwealth of Pennsylvania Department of Health FX This study was supported in part by the National Institutes of Health (NIH) Intramural Research Program (Grant No. Z01 AR41131), the Department of Defense Military Amputee Research Program at WRAMC (Department of the Army, U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 217025014 is the awarding and administering acquisition office, Grant No. PO5-A011), the Comprehensive Neurosciences Program (The Uniformed Services University of the Health Sciences (USU), 4301 Jones Bridge Rd. Bethesda, MD 20814-4799 is the awarding and administering office, Grant No. CNP-2008-CR01) and the Peer-reviewed Orthopedic Research Program (Department of the Army, U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office, Grant No. W81XWH-10-2-0084), and from the Commonwealth of Pennsylvania Department of Health. The authors thank Dr Paul Manner, University of Washington, for providing human skeletal tissues, and Ibardo Zambrano and Richard Booth for technical assistance. NR 41 TC 4 Z9 4 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD JUN PY 2013 VL 7 IS 6 BP 443 EP 451 DI 10.1002/term.539 PG 9 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 156OE UT WOS:000319831100003 PM 22552971 ER PT J AU Phasomkusolsil, S Tawong, J Monkanna, N Pantuwatana, K Damdangdee, N Khongtak, W Kertmanee, Y Evans, BP Schuster, AL AF Phasomkusolsil, Siriporn Tawong, Jaruwan Monkanna, Nantaporn Pantuwatana, Kanchana Damdangdee, Nuttapon Khongtak, Weeraphan Kertmanee, Yossasin Evans, Brian P. Schuster, Anthony L. TI Maintenance of mosquito vectors: effects of blood source on feeding, survival, fecundity, and egg hatching rates SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Blood source; feeding; fecundity; Anopheles; Aedes ID ANOPHELES-STEPHENSI; AEDES-ALBOPICTUS; CULICIDAE; DIPTERA; MEAL; ALBIMANUS; MALARIA; SIZE AB Artificial membrane-feeding techniques have replaced direct feeding on animals for the maintenance of malaria and arbovirus vectors in many laboratories. Membrane feeding facilitates controlled experimentation of pathogen transmission during mosquito feeding. Sheep blood is commonly used due to its availability and low cost. We evaluated the impact of blood source (human, guinea pig, sheep, and hamster via direct feeding) on feeding rates, adult survival, fecundity, hatching rates, and developmental times for five species of laboratory-colonized mosquitoes (Anopheles dirus, An. cracens, An. minimus, An. sawadwongporni, and Ae. aegypti). We found that feeding rates differ among blood sources within mosquito species. Survival, fecundity, and hatching rates were lower in all Anopheles species and Ae. aegypti after membrane feeding on sheep blood. Survival rates seven days post-feeding on sheep blood were significantly lower (P<0.05) for An. dirus (84.2%), An. minimus (67.2%), An. sawadwongporni (51.5%), and An. cracens (35.5%) relative to other blood sources. An. minimus and An. sawadwongporni laid no eggs by seven days post-feeding with sheep blood, while An. dirus and An. cracens produced significantly fewer numbers of eggs and demonstrated significantly lower hatching rates relative to what was observed with the other blood sources. These findings support the conclusion that sheep blood is not a suitable blood source for laboratory rearing of Anopheles spp. C1 [Evans, Brian P.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. US Army Publ Hlth Command Reg Pacific, Unit 45006, Apo, AP 96343, Japan. EM siripornp@afrims.org FU U.S. Army Medical and Material Command FX Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011 edition. Funding for this project was partially provided by the U.S. Army Medical and Material Command. The views expressed in this paper are those of the authors and do not represent the position and/or reflect the official policy of the Department of the Army, the Department of Defense or the U.S. Government. We also wish to express our gratitude to COL Chaiyaphruk Pilakasiri for reviewing and comments on the manuscript. NR 19 TC 5 Z9 5 U1 2 U2 29 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2013 VL 38 IS 1 BP 38 EP 45 DI 10.1111/j.1948-7134.2013.12006.x PG 8 WC Entomology SC Entomology GA 150VX UT WOS:000319420600005 PM 23701605 ER PT J AU Lutomiah, J Bast, J Clark, J Richardson, J Yalwala, S Oullo, D Mutisya, J Mulwa, F Musila, L Khamadi, S Schnabel, D Wurapa, E Sang, R AF Lutomiah, Joel Bast, Joshua Clark, Jeffrey Richardson, Jason Yalwala, Santos Oullo, David Mutisya, James Mulwa, Francis Musila, Lillian Khamadi, Samoel Schnabel, David Wurapa, Eyako Sang, Rosemary TI Abundance, diversity, and distribution of mosquito vectors in selected ecological regions of Kenya: public health implications SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Mosquito density; diversity; ecology; transmission ID RIFT-VALLEY FEVER; WEST-NILE-VIRUS; AEDES-AEGYPTI; YELLOW-FEVER; ENTOMOLOGIC INVESTIGATIONS; ARBOVIRAL INFECTIONS; SOUTH-AFRICA; OUTBREAK; DIPTERA; SEROPREVALENCE AB The diversity of mosquito arbovirus vectors was investigated to define regional risk of arbovirus transmission in Kenya. Mosquitoes were sampled between April, 2007 and December, 2010 at thirteen sites across seven administrative provinces and ecological zones. CDC light traps were used to collect mosquitoes while human-landing collection was conducted in five of the sites to target day-feeding Aedes (Stegomyia) species. Over 524,000 mosquitoes were collected and identified into 101 species, 30 of them known vectors of arboviruses endemic to Kenya. Ae. (Neomelaniconion) mcintoshi and Ae. (Aedimorphus) ochraceus were most abundant in Garissa in the arid northeastern province, and Mansonia uniformis and Mn. africana in semi-arid Baringo in the Rift Valley Province. Ae. ochraceus, Mn. africana and Mn. uniformis were also significant in Nyanza Province, while Ae. (Neomelaniconion) circumluteolus predominated in Budalangi, Western Province. Aedes (Stegomyia) aegypti was predominant in Rabai in the Coast Province but insignificant in the western and Nyanza sites. Culex pipiens was abundant in Rift Valley and Nyanza Provinces around the lake shores. This study highlights the potential for emergence and re-emergence of arboviral diseases among vulnerable populations. This calls for comprehensive mapping of vector distribution and abundance for planning focused vector control measures. C1 [Lutomiah, Joel; Khamadi, Samoel; Sang, Rosemary] Kenya Med Res Inst KEMRI, Nairobi, Kenya. [Bast, Joshua; Yalwala, Santos; Oullo, David] US Army Med Res Unit USAMRU K, Kisumu, Kenya. [Lutomiah, Joel; Mutisya, James; Musila, Lillian; Wurapa, Eyako; Sang, Rosemary] US Army Med Res Unit USAMRU K, Nairobi, Kenya. [Clark, Jeffrey] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Richardson, Jason; Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Lutomiah, J (reprint author), Kenya Med Res Inst KEMRI, Nairobi, Kenya. EM joel.lutomiah@usamru-k.org RI Valle, Ruben/A-7512-2013 FU Department of Emerging Infectious Diseases (DEID); USAMRU-K; AFHSC FX We thank Dunston Beti, John Gachoya, Reuben Lugalia, Daniel Ngonga, and Anthony Mutai for their expert contribution in mosquito sampling and identification. This project was fully supported by the Department of Emerging Infectious Diseases (DEID), USAMRU-K, AFHSC. The content is solely the views of the authors and does not represent the official views of AFHSC. NR 46 TC 20 Z9 20 U1 1 U2 19 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2013 VL 38 IS 1 BP 134 EP 142 DI 10.1111/j.1948-7134.2013.12019.x PG 9 WC Entomology SC Entomology GA 150VX UT WOS:000319420600018 PM 23701618 ER PT J AU Klun, JA Kramer, M Debboun, M AF Klun, Jerome A. Kramer, Matthew Debboun, Mustapha TI Four simple stimuli that induce host-seeking and blood-feeding behaviors in two mosquito species, with a clue to DEET's mode of action SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Mosquito repellent; mosquito wind tunnel; ATP; water vapor; carbon dioxide ID HUMAN SKIN EMANATIONS; AEDES-AEGYPTI; CARBON-DIOXIDE; GORGING RESPONSE; BIOASSAY SYSTEM; ATP ANALOGS; WIND-TUNNEL; CULICIDAE; DIPTERA; IDENTIFICATION AB Bioassays in a wind tunnel showed that a combination of four stimuli releases intense host-seeking and blood-feeding behavioral responses from females of the Asian tiger mosquito, Aedes albopictus, and the yellow fever mosquito, Aedes aegypti. The stimuli are carbon dioxide, water vapor, warmth, and adenosine triphosphate (ATP). Mosquitoes responded to this combination with a repertoire of blood-feeding behaviors that included upwind flight, landing, probing, and engorgement. Absence of carbon dioxide, water vapor, or ATP from the combination of stimuli or exposure to temperatures 12 degrees C below or above human-host temperature (38 degrees C) significantly attenuated blood-feeding behavior in both species. Although there is literature documenting the individual importance of each of these stimuli, our work represents the first instance where this combination of stimuli was found sufficient to elicit a complete repertoire of blood-feeding behaviors in these mosquitoes without involvement of any host specific odor. When mosquitoes were exposed to the four stimuli along with N,N-diethyl-3-methylbenzamide (DEET), feeding behavior was greatly suppressed. We hypothesize that a possible mode of action for DEET against these mosquitoes involves interference of warmth and/or water vapor receptors. An electrophysiological study designed to determine if DEET adversely affects the function of these receptors would be illuminating. C1 [Klun, Jerome A.] ARS, USDA, Potomac, MD 20854 USA. [Kramer, Matthew] ARS, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [Debboun, Mustapha] USA, Med Dept Ctr & Sch, Acad Hlth Sci, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. RP Kramer, M (reprint author), ARS, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. EM matt.kramer@ars.usda.gov NR 40 TC 7 Z9 7 U1 3 U2 20 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2013 VL 38 IS 1 BP 143 EP 153 DI 10.1111/j.1948-7134.2013.12020.x PG 11 WC Entomology SC Entomology GA 150VX UT WOS:000319420600019 PM 23701619 ER PT J AU Vadera, S Marathe, AR Gonzalez-Martinez, J Taylor, DM AF Vadera, Sumeet Marathe, Amar R. Gonzalez-Martinez, Jorge Taylor, Dawn M. TI Stereoelectroencephalography for continuous two-dimensional cursor control in a brain-machine interface SO NEUROSURGICAL FOCUS LA English DT Article DE stereoelectroencephalography; depth electrode; brain-machine interface; brain-computer interface; epilepsy monitoring unit ID MOVEMENT TRAJECTORIES; COMPUTER INTERFACES; FINGER MOVEMENTS; HUMANS; TETRAPLEGIA; ECOG; ARM; ELECTRODES; SIGNALS; GRASP AB Stereoelectroencephalography (SEEG) is becoming more prevalent as a planning tool for surgical treatment of intractable epilepsy. Stereoelectroencephalography uses long, thin, cylindrical "depth" electrodes containing multiple recording contacts along each electrode's length. Each lead is inserted into the brain percutaneously. The advantage of SEEG is that the electrodes can easily target deeper brain structures that are inaccessible with subdural grid electrodes, and SEEG does not require a craniotomy. Brain-machine interface (BMI) research is also becoming more common in the Epilepsy Monitoring Unit. A brain-machine interface decodes a person's desired movement or action from the recorded brain activity and then uses the decoded brain activity to control an assistive device in real time. Although BMIs are primarily being developed for use by severely paralyzed individuals, epilepsy patients undergoing invasive brain monitoring provide an opportunity to test the effectiveness of different invasive recording electrodes for use in BMI systems. This study investigated the ability to use SEEG electrodes for control of 2D cursor velocity in a BMI. Two patients who were undergoing SEEG for intractable epilepsy participated in this study. Participants were instructed to wiggle or rest the hand contralateral to their SEEG electrodes to control the horizontal velocity of a cursor on a screen. Simultaneously they were instructed to wiggle or rest their feet to control the vertical component of cursor velocity. The BMI system was designed to detect power spectral changes associated with hand and foot activity and translate those spectral changes into horizontal and vertical cursor movements in real time. During testing, participants used their decoded SEEG signals to move the brain-controlled cursor to radial targets that appeared on the screen. Although power spectral information from 28 to 32 electrode contacts were used for cursor control during the experiment, post hoc analysis indicated that better control may have been possible using only a single SEEG depth electrode containing multiple recording contacts in both hand and foot cortical areas. These results suggest that the advantages of using SEEG for epilepsy monitoring may also apply to using SEEG electrodes in BMI systems. Specifically, SEEG electrodes can target deeper brain structures, such as foot motor cortex, and both hand and foot areas can be targeted with a single SEEG electrode implanted percutaneously. Therefore, SEEG electrodes may be an attractive option for simple BMI systems that use power spectral modulation in hand and foot cortex for independent control of 2 degrees of freedom. (http://thejns.org/doi/abs/10.3171/2013.3.FOCUS1373) C1 [Vadera, Sumeet; Gonzalez-Martinez, Jorge] Cleveland Clin, Dept Neurosurg, Cleveland, OH 44195 USA. [Marathe, Amar R.; Taylor, Dawn M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA. [Marathe, Amar R.; Taylor, Dawn M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA. [Marathe, Amar R.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH USA. [Marathe, Amar R.; Taylor, Dawn M.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Taylor, DM (reprint author), Cleveland Clin, Lerner Res Inst, 9500 Euclid Ave,NC30, Cleveland, OH 44195 USA. EM dxt42@case.edu FU National Institute of Neurological Disorders and Stroke, NIH [R01-NS058871]; Department of Veterans Affairs (Merit Review) [B4195R]; Cleveland Clinic; Case Western Reserve University FX This work was supported by the National Institute of Neurological Disorders and Stroke, NIH (grant no. R01-NS058871), the Department of Veterans Affairs (Merit Review no. B4195R), the Cleveland Clinic, and Case Western Reserve University. NR 36 TC 4 Z9 4 U1 2 U2 8 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD JUN PY 2013 VL 34 IS 6 AR E3 DI 10.3171/2013.3.FOCUS1373 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 155HA UT WOS:000319737400004 PM 23724837 ER PT J AU Mansi, I Frei, CR Pugh, MJ Mortensen, EM AF Mansi, Ishak Frei, Christopher R. Pugh, Mary J. Mortensen, Eric M. TI Psychologic Disorders and Statin Use: A Propensity Score-Matched Analysis SO PHARMACOTHERAPY LA English DT Article DE statin; schizophrenia; depression; adverse events; psychological injury; observational study ID OF-THE-LITERATURE; DEPRESSIVE SYMPTOMS; OLDER PERSONS; CHOLESTEROL; SIMVASTATIN; TRIAL; MOOD; ATORVASTATIN; VOLUNTEERS; DIAGNOSIS AB Study Objective To evaluate the association between statin therapy and the risk of psychologic disorders including schizophrenia, psychosis, major depression, and bipolar disorder in a military population. Design Retrospective, observational, population-based, propensity score-matched, cohort study. Setting Database of a patient population enrolled in the San Antonio Military Multi-Market Area as Tricare Prime or Plus. Patients Medical records were reviewed from 46,249 patients aged 30-85years who were continuously enrolled in the San Antonio Military Multi-Market Area as Tricare Prime or Plus from October 1, 2003-March 1, 2010. Data were obtained from the Military Health System Management Analysis and Reporting Tool (M2). Based on drug fills during fiscal year 2005, patients were stratified as statin users (13,626 patients received at least 90-days supply of statin) or nonusers (32,623 patients never received a statin during the study period). A propensity score-matched cohort of 6972 statin users and 6972 nonusers from this population was created. Measurements and Main Results The occurrence of psychologic disorders between October 1, 2005, and March 1, 2010, was determined using prespecified groups of ICD-9-CM, Psych1: schizophrenia, schizoaffective disorders, and other psychosis; Psych2: major depression and bipolar disorder; Psych3: all psychologic disorders as identified by the Agency for Health Research and Quality-Clinical Classifications (except for categories of childhood or developmental psychiatric disorders). Between matched pairs of statin users and nonusers, the odds ratios and 95% confidence intervals were as follows: Psych1 (0.9, 0.75-1.05), Psych2 (1.02, 0.94-1.11), and Psych3 (1.02, 0.96-1.1), respectively. Conclusion The risk of developing psychologic disorders was similar in this cohort of propensity score-matched statin users and nonusers. C1 [Mansi, Ishak] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Mansi, Ishak] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mansi, Ishak; Pugh, Mary J.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. [Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA. [Mortensen, Eric M.] VA North Texas Hlth Care Syst, Dallas, TX 75216 USA. [Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, Internal Med Serv, 4500 S Lancaster 111E, Dallas, TX 75216 USA. EM ishak.mansi@va.gov OI Mortensen, Eric/0000-0002-3880-5563 FU U.S. National Institutes of Health (NIH) [RR025766]; AstraZeneca; Bristol Myers Squibb; Elan; Forest; Ortho-McNeil Janssen; Pfizer FX CRF is supported by the U.S. National Institutes of Health (NIH) in the form of a NIH/KL2 career development award (RR025766). In addition, CRF has received research grants and/or served as a scientific consultant/advisor for AstraZeneca, Bristol Myers Squibb, Elan, Forest, Ortho-McNeil Janssen, and Pfizer. NR 47 TC 13 Z9 13 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD JUN PY 2013 VL 33 IS 6 BP 615 EP 626 DI 10.1002/phar.1272 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 157DP UT WOS:000319876300011 PM 23625731 ER PT J AU Markov, NP Percival, TJ Morrison, JJ Ross, JD Scott, DJ Spencer, JR Rasmussen, TE AF Markov, Nickolay P. Percival, Thomas J. Morrison, Jonathan J. Ross, James D. Scott, Daniel J. Spencer, Jerry R. Rasmussen, Todd E. TI Physiologic tolerance of descending thoracic aortic balloon occlusion in a swine model of hemorrhagic shock SO SURGERY LA English DT Article ID EMERGENCY-DEPARTMENT THORACOTOMY; PORCINE MODEL; MANAGEMENT; TRAUMA; US AB Background. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emerging technique in trauma; however, the physiologic sequelae have not been well quantified. The objectives of this study were to characterize the burden of reperfusion and organ dysfunction of REBOA incurred during 30 or 90 min of class IV shock in a survivable porcine model of hemorrhage. Methods. After induction of shock, animals were randomized into 4 groups (n = 6): 30 min of shock alone (30-Shock) or with REBOA (30-REBOA) and 90 min of shock alone (90-Shock) or with REBOA (90-REBOA). Cardiovascular homeostasis was then restored with blood, fluid, and vasapressors for 48 h. Outcomes included mean central aortic pressure (MCAP), lactate concentration, organ dysfunction, histologic evaluation, and resuscitation requirements. Results. Both REBOA groups had greater MCAPs throughout their shock phase compared to controls (P < .05) but accumulated a significantly greater serum lactate burden, which returned to control levels by 150 min in the 30-REBOA groups and 320 min in the 90-REBOA group. There was a greater level of renal dysfunction and evidence of liver necrosis seen in the 90-REBOA group compared to the 90-Shock group. There was no evidence of cerebral or spinal cord necrosis in any group. The 90-RE130A group required more fluid resuscitation than the 90-Shock group (P = .05). Conclusion. REBO4 in shock improves MCAP and is associated with a greater lactate burden; however, this lactate burden returned to control levels within the study period. Ultimately, prolonged REBOA is a survivable and potentially life-saving intervention in the setting of hemorrhagic shock and cardiovascular collapse in the pig. C1 [Markov, Nickolay P.; Percival, Thomas J.; Morrison, Jonathan J.; Ross, James D.; Scott, Daniel J.; Spencer, Jerry R.; Rasmussen, Todd E.] Lackland AFB, Med Wing 59, Ft Sam Houston, TX USA. [Markov, Nickolay P.; Percival, Thomas J.; Morrison, Jonathan J.; Scott, Daniel J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil OI Morrison, Jonathan/0000-0001-7462-8456 FU US Air Force, Clinical Research Division, Lackland AF Base, San Antonio, TX FX Supported by the US Air Force, Clinical Research Division, Lackland AF Base, San Antonio, TX. NR 19 TC 34 Z9 34 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD JUN PY 2013 VL 153 IS 6 BP 848 EP 856 DI 10.1016/j.surg.2012.12.001 PG 9 WC Surgery SC Surgery GA 157JC UT WOS:000319891400013 PM 23453327 ER PT J AU Ofula, VO Franklin, AB Root, JJ Sullivan, HJ Gichuki, P Makio, A Bulimo, W Abong'o, BO Muchai, M Schnabel, D AF Ofula, Victor O. Franklin, Alan B. Root, J. Jeffrey Sullivan, Heather J. Gichuki, Patrick Makio, Albina Bulimo, Wallace Abong'o, Bernard O. Muchai, Muchane Schnabel, David TI Detection of Avian Influenza Viruses in Wild Waterbirds in the Rift Valley of Kenya Using Fecal Sampling SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Africa; Aves; Avian influenza virus; Feces; Nondomestic animals; Waterfowl ID H5N1 VIRUSES; A VIRUSES; BIRDS; AFRICA; SURVEILLANCE; PERSISTENCE; HEMAGGLUTININ; EMERGENCE; WATERFOWL; PATTERNS AB Highly pathogenic avian influenza virus A/H5N1 has been reported in 11 African countries. Migratory waterbirds have the potential of introducing A/H5N1 into east Africa through the Rift Valley of Kenya. We present the results of a wild bird surveillance system for A/H5N1 and other avian influenza viruses based on avian fecal sampling in Kenya. We collected 2630 fecal samples in 2008. Viral RNA was extracted from pools of 3-5 fecal samples and analyzed for presence of avian influenza virus RNA by real-time RT-PCR. Twelve (2.3%) of the 516 sample pools were positive for avian influenza virus RNA, 2 of which were subtyped as H4N6 viruses. This is the first report of avian influenza virus in wild birds in Kenya. This study demonstrates the success of this approach in detecting avian influenza virus in wild birds and represents an efficient surveillance system for avian influenza virus in regions with limited resources. C1 [Ofula, Victor O.; Makio, Albina; Bulimo, Wallace; Schnabel, David] US Army Med Res Unit Kenya, Nairobi, Kenya. [Franklin, Alan B.; Root, J. Jeffrey; Sullivan, Heather J.] Natl Wildlife Res Ctr, Ft Collins, CO USA. [Gichuki, Patrick; Muchai, Muchane] Natl Museums Kenya, Nairobi, Kenya. [Abong'o, Bernard O.] Great Lakes Univ Kisumu, Kisumu, Kenya. RP Schnabel, D (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM david.c.schnabel@us.army.mil RI Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU U.S. Department of Defense, Armed Forces Health Surveillance Center, Division of GEIS Operations FX We would like to acknowledge Samuel Owaka for his assistance in sample collections; Finley Osuna, Meshack Wadegu, Ben Kiawa, and Darcy Orahood for assistance in laboratory testing; and Jeremy Ellis for his assistance with map development. We would also like to thank Dr. Rosemary Sang for providing laboratory space at the Kenya Medical Research Institute, Centre for Virus Research, Nairobi, Kenya. Funding for this work was provided by the U.S. Department of Defense, Armed Forces Health Surveillance Center, Division of GEIS Operations. NR 48 TC 0 Z9 0 U1 2 U2 14 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUN PY 2013 VL 13 IS 6 BP 394 EP 400 DI 10.1089/vbz.2011.0926 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 157NV UT WOS:000319905800008 PM 23621372 ER PT J AU Meeks, JJ Walker, M Bernstein, M Eastham, JA AF Meeks, Joshua J. Walker, Marc Bernstein, Melanie Eastham, James A. TI Seminal vesicle involvement at salvage radical prostatectomy SO BJU INTERNATIONAL LA English DT Article DE prostate cancer; radiation therapy; radical prostatectomy; seminal vesicle invasion ID LYMPH-NODE DISSECTION; RADIATION-THERAPY; CANCER; BIOPSY; IRRADIATION; RADIOTHERAPY; IMPLANTATION; CARCINOMA; INVASION; OUTCOMES AB Objective To describe the incidence and clinical outcomes of seminal vesicle invasion (SVI) at salvage radical prostatectomy (SRP) and to describe the accuracy of SV biopsy. As SRP is used after biochemical recurrence (BCR) of prostate cancer after radiotherapy (RT) to gain local oncological control. The SVs receive lower doses of radiation from external-beam RT (EBRT) to avoid rectal exposure and are not targeted with brachytherapy (BT) with low-risk prostate cancer. Patients and Methods SRP was performed on 206 men with BCR after RT at a tertiary care institution between 1998 and 2011. Post-RT biopsy and SRP specimens were reviewed by a genitourinary pathologist. Results SVI was detected in 65 (32%) of 206 patients. No difference was found between EBRT alone (65% vs 63%) and BT (29% vs 31%) with or without EBRT in patients with SVI. Men with SVI had higher rates of cT3 disease (20% vs 8%) and Gleason score 8 at SRP (52% vs 21%). BCR-free survival at 5 years was 18% and 56% in patients with and without SVI (hazard ratio 2.85, 95% confidence interval 1.87-4.36, P < 0.001), yet the rate of local recurrence was low (11%). Prostate cancer was identified in nine of 18 patients who underwent SV biopsy and was the only location of prostate cancer in two patients. Conclusions SVI is a prognostic indicator for BCR after SRP, but local recurrence in patients with SVI after SRP remains low. We recommend SV biopsy to improve staging and cancer detection in men with BCR after radiotherapy. C1 [Meeks, Joshua J.; Bernstein, Melanie; Eastham, James A.] Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, New York, NY 10021 USA. [Walker, Marc] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. RP Eastham, JA (reprint author), Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, 353 East 68th St, New York, NY 10021 USA. EM easthamj@mkscc.org OI Bernstein, Melanie/0000-0002-0681-6188 NR 21 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-4096 J9 BJU INT JI BJU Int. PD JUN PY 2013 VL 111 IS 8 BP E342 EP E347 DI 10.1111/bju.12034 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 152GW UT WOS:000319520800010 PM 23495695 ER PT J AU Thomas, AW Garner, LE Nevin, KP Woodard, TL Franks, AE Lovley, DR Sumner, JJ Sund, CJ Bazan, GC AF Thomas, Alexander W. Garner, Logan E. Nevin, Kelly P. Woodard, Trevor L. Franks, Ashley E. Lovley, Derek R. Sumner, James J. Sund, Christian J. Bazan, Guillermo C. TI A lipid membrane intercalating conjugated oligoelectrolyte enables electrode driven succinate production in Shewanella SO ENERGY & ENVIRONMENTAL SCIENCE LA English DT Article ID MICROBIAL FUEL-CELLS; REDUCED NEUTRAL RED; GEOBACTER-SULFURREDUCENS; BACTERIA; ELECTRICITY; MR-1; PERFORMANCE; REDUCTION; NETWORKS; BIOFILMS AB An amphiphilic conjugated oligoelectrolyte (COE) that spontaneously intercalates into lipid membranes enables Shewanella oneidensis to use a graphite electrode as the sole electron donor for succinate production. Current consumed in a poised electrochemical system by Shewanella with micromolar concentrations of COE correlates well with the succinate produced via fumarate reduction as determined by HPLC analysis. Confocal microscopy confirms incorporation of the COE into the microbes on the electrode surface. This work presents a unique strategy to induce favorable bio-electronic interactions for the production of reduced microbial metabolites. C1 [Thomas, Alexander W.; Garner, Logan E.; Bazan, Guillermo C.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Nevin, Kelly P.; Woodard, Trevor L.; Franks, Ashley E.; Lovley, Derek R.] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA. [Franks, Ashley E.] La Trobe Univ, Dept Microbiol, Bundoora, Vic 3086, Australia. [Sumner, James J.; Sund, Christian J.] USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Thomas, AW (reprint author), Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. EM bazan@chem.ucsb.edu RI Bazan, Guillermo/B-7625-2014 FU Institute for Collaborative Biotechnologies [W91NF-09-0001]; Advanced Research Projects Agency-Energy (ARPA-E), U.S. Department of Energy [DE-AR0000159] FX The authors thank the Institute for Collaborative Biotechnologies (W91NF-09-0001), and award no. DE-AR0000159 from the Advanced Research Projects Agency-Energy (ARPA-E), U.S. Department of Energy to DRL for financial support. NR 48 TC 28 Z9 28 U1 1 U2 80 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1754-5692 J9 ENERG ENVIRON SCI JI Energy Environ. Sci. PD JUN PY 2013 VL 6 IS 6 BP 1761 EP 1765 DI 10.1039/c3ee00071k PG 5 WC Chemistry, Multidisciplinary; Energy & Fuels; Engineering, Chemical; Environmental Sciences SC Chemistry; Energy & Fuels; Engineering; Environmental Sciences & Ecology GA 148YF UT WOS:000319284200009 ER PT J AU Rajanna, C Ouellette, G Rashid, M Zemla, A Karavis, M Zhou, C Revazishvili, T Redmond, B McNew, L Bakanidze, L Imnadze, P Rivers, B Skowronski, EW O'Connell, KP Sulakvelidze, A Gibbons, HS AF Rajanna, Chythanya Ouellette, Gary Rashid, Mohammed Zemla, Adam Karavis, Mark Zhou, Carol Revazishvili, Tamara Redmond, Brady McNew, Lauren Bakanidze, Lela Imnadze, Paata Rivers, Bryan Skowronski, Evan W. O'Connell, Kevin P. Sulakvelidze, Alexander Gibbons, Henry S. TI A strain of Yersinia pestis with a mutator phenotype from the Republic of Georgia SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Yersinia pestis; mutator; DNA repair; mutS; evolution ID TEMPERATURE-DEPENDENT VARIATIONS; COMPLETE GENOME SEQUENCE; ESCHERICHIA-COLI; BACTERIAL-POPULATIONS; PHYLOGENETIC ANALYSIS; TANDEM REPEATS; MUTS GENE; PLAGUE; EVOLUTION; RATES AB We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y.pestis. The responsible mutation, a C to T substitution in the mutS gene, results in the transition of a highly conserved leucine at position 689 to arginine (mutS(L689R)). When the MutSL689R protein of G1670A was expressed in a mutS derivative of Y.pestis strain EV76, mutation rates observed were equivalent to those observed in G1670A, consistent with a causal association between the mutS mutation and the mutator phenotype. The observation of a mutator allele in Yersinia pestis has potential implications for the study of evolution of this and other especially dangerous pathogens. C1 [Rajanna, Chythanya; Rashid, Mohammed; Revazishvili, Tamara; Sulakvelidze, Alexander] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA. [Ouellette, Gary; Karavis, Mark; Redmond, Brady; McNew, Lauren; Rivers, Bryan; Skowronski, Evan W.; O'Connell, Kevin P.; Gibbons, Henry S.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Ouellette, Gary] Sci Applicat Int Inc, Aberdeen Proving Ground, MD USA. [Zemla, Adam; Zhou, Carol] Lawrence Livermore Natl Lab, Livermore, CA USA. [Bakanidze, Lela; Imnadze, Paata] Natl Ctr Dis Control, Tbilisi, Rep of Georgia. RP Gibbons, HS (reprint author), USA, Edgewood Chem Biol Ctr, RDCB DRB M, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM henry.s.gibbons.civ@mail.mil NR 36 TC 3 Z9 3 U1 0 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0378-1097 EI 1574-6968 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD JUN PY 2013 VL 343 IS 2 BP 113 EP 120 DI 10.1111/1574-6968.12137 PG 8 WC Microbiology SC Microbiology GA 152ET UT WOS:000319514300002 PM 23521061 ER PT J AU McGann, P Milillo, M Clifford, RJ Snesrud, E Stevenson, L Backlund, MG Viscount, HB Quintero, R Kwak, YI Zapor, MJ Waterman, PE Lesho, EP AF McGann, Patrick Milillo, Michael Clifford, Robert J. Snesrud, Erik Stevenson, Lindsay Backlund, Michael G. Viscount, Helen B. Quintero, Reyes Kwak, Yoon I. Zapor, Michael J. Waterman, Paige E. Lesho, Emil P. TI Detection of New Delhi Metallo-beta-Lactamase (Encoded by bla(NDM-1)) in Acinetobacter schindleri during Routine Surveillance SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID EMERGING CARBAPENEMASES; MULTIDRUG-RESISTANCE; IDENTIFICATION; BAUMANNII; URSINGII; PLASMID; PCR AB A carbapenem-resistant Alcaligenes faecalis strain was isolated from a surveillance swab of a service member injured in Afghanistan. The isolate was positive for bla(NDM) by real-time PCR. Species identification was reevaluated on three identification systems but was inconclusive. Genome sequencing indicated that the closest relative was Acinetobacter schindleri and that bla(NDM-1) was carried on a plasmid that shared >99% identity with one identified in an Acinetobacter lwoffii isolate. The isolate also carried a novel chromosomally encoded class D oxacillinase. C1 [McGann, Patrick; Milillo, Michael; Clifford, Robert J.; Snesrud, Erik; Quintero, Reyes; Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Stevenson, Lindsay; Backlund, Michael G.; Viscount, Helen B.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. [Zapor, Michael J.] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann4.ctr@mail.mil FU Global Emerging Infections Surveillance and Response System (GEIS) [C070912WR]; Defense Medical Research and Development Program (DMRDP) [D61I10J258] FX Major funding for this project was provided by the Global Emerging Infections Surveillance and Response System (GEIS; grant number C070912WR) and Defense Medical Research and Development Program (DMRDP; grant number D61I10J258). NR 19 TC 9 Z9 10 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2013 VL 51 IS 6 BP 1942 EP 1944 DI 10.1128/JCM.00281-13 PG 3 WC Microbiology SC Microbiology GA 147VV UT WOS:000319197800048 PM 23554204 ER PT J AU Ji, SY Belle, A Ward, KR Ryan, KL Rickards, CA Convertino, VA Najarian, K AF Ji, Soo-Yeon Belle, Ashwin Ward, Kevin R. Ryan, Kathy L. Rickards, Caroline A. Convertino, Victor A. Najarian, Kayvan TI Heart rate variability analysis during central hypovolemia using wavelet transformation SO JOURNAL OF CLINICAL MONITORING AND COMPUTING LA English DT Article DE Heart rate variability (HRV); RR interval; Discrete wavelet transformation; Power spectral density; Higuchi fractal dimension; Lower body negative pressure (LBNP) ID BODY NEGATIVE-PRESSURE; FRACTAL DIMENSION; TRAUMA PATIENTS; PERIOD VARIABILITY; AUTONOMIC FUNCTION; HEMORRHAGIC-SHOCK; SPECTRAL-ANALYSIS; TIME-SERIES; COMPLEXITY; MORTALITY AB Detection of hypovolemia prior to overt hemodynamic decompensation remains an elusive goal in the treatment of critically injured patients in both civilian and combat settings. Monitoring of heart rate variability has been advocated as a potential means to monitor the rapid changes in the physiological state of hemorrhaging patients, with the most popular methods involving calculation of the R-R interval signal's power spectral density (PSD) or use of fractal dimensions (FD). However, the latter method poses technical challenges, while the former is best suited to stationary signals rather than the non-stationary R-R interval. Both approaches are also limited by high inter- and intra-individual variability, a serious issue when applying these indices to the clinical setting. We propose an approach which applies the discrete wavelet transform (DWT) to the R-R interval signal to extract information at both 500 and 125 Hz sampling rates. The utility of machine learning models based on these features were tested in assessing electrocardiogram signals from volunteers subjected to lower body negative pressure induced central hypovolemia as a surrogate of hemorrhage. These machine learning models based on DWT features were compared against those based on the traditional PSD and FD, at both sampling rates and their performance was evaluated based on leave-one-subject-out fold cross-validation. Results demonstrate that the proposed DWT-based model outperforms individual PSD and FD methods as well as the combination of these two traditional methods at both sample rates of 500 Hz (p value < 0.0001) and 125 Hz (p value < 0.0001) in detecting the degree of hypovolemia. These findings indicate the potential of the proposed DWT approach in monitoring the physiological changes caused by hemorrhage. The speed and relatively low computational costs in deriving these features may make it particularly suited for implementation in portable devices for remote monitoring. C1 [Ji, Soo-Yeon] Bowie State Univ, Bowie, MD USA. [Belle, Ashwin; Najarian, Kayvan] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Ward, Kevin R.] Univ Michigan Hlth Syst, Ann Arbor, MI USA. [Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res USISR, Ft Sam Houston, TX USA. [Rickards, Caroline A.] Univ North Texas Hlth Sci Ctr, Ft Worth, TX USA. RP Najarian, K (reprint author), Virginia Commonwealth Univ, Richmond, VA 23284 USA. EM knajarian@vcu.edu OI Belle, Ashwin/0000-0002-8084-3563 FU National Science Foundation [IIS0758410]; U.S. Army Medical Research and Material Command Combat Casualty Care Research Program [05-0033-02] FX This material is based upon work supported by the National Science Foundation under Grant No. IIS0758410 and by the U.S. Army Medical Research and Material Command Combat Casualty Care Research Program (Grant: 05-0033-02). The opinions expressed herein are the personal opinions of the authors and are not to be construed as representing those of the Department of Defense, the Department of the Army, or the United States Army. NR 49 TC 5 Z9 6 U1 1 U2 12 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1387-1307 J9 J CLIN MONIT COMPUT JI J. Clin. Monitor. Comp. PD JUN PY 2013 VL 27 IS 3 BP 289 EP 302 DI 10.1007/s10877-013-9434-9 PG 14 WC Anesthesiology SC Anesthesiology GA 146DW UT WOS:000319070600012 PM 23371800 ER PT J AU Champagne, V Helfritch, D Wienhold, E DeHaven, J AF Champagne, Victor Helfritch, Dennis Wienhold, Erik DeHaven, Jennifer TI Deposition of copper micro-circuitry by capillary focusing SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article AB The application of fine line micro-circuitry onto ceramic substrates currently requires a multi step process including printing, baking and sintering. A new, one-step, process utilizing particle impact deposition is presented. This process directs a high velocity stream of copper particles within a helium carrier onto a ceramic substrate. Upon impact the particles deform and adhere to the substrate and to previously deposited particles. The use of a capillary tube as the flow nozzle restricts the jet and the resulting deposited copper to micron scale dimensions. The deposited copper is dense, with near zero porosity. Robot control of the jet position can yield precise conduction lines and component connections. C1 [Champagne, Victor] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Helfritch, Dennis] Dynam Sci Inc, Aberdeen, MD USA. [Wienhold, Erik] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [DeHaven, Jennifer] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO USA. RP Champagne, V (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. EM victor.k.champagne.civ@mail.mil NR 8 TC 3 Z9 3 U1 1 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD JUN PY 2013 VL 23 IS 6 AR 065023 DI 10.1088/0960-1317/23/6/065023 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 151HM UT WOS:000319451300023 ER PT J AU Hergert, RJ Hanrahan, B Ghodssi, R Holmes, AS AF Hergert, Robert J. Hanrahan, Brendan Ghodssi, Reza Holmes, Andrew S. TI Performance of integrated retainer rings in silicon micro-turbines with thrust style micro-ball bearings SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID MEMS AB This work explores the performance of different silicon retainer ring designs when integrated into silicon micro-turbines (SMTs) incorporating thrust style bearings supported on 500 mu m diameter steel balls. Experimental performance curves are presented for SMTs with rotor diameters of 5 mm and 10 mm, each with five different retainer designs varying in mechanical rigidity, ball pocket shape and ball complement. It was found that the different retainer designs yielded different performance curves, with the closed pocket designs consistently requiring lower input power for a given rotation speed, and the most rigid retainers giving the best performance overall. Both 5 mm and 10 mm diameter devices have shown repeatable performance at rotation speeds up to and exceeding 20 000 RPM with input power levels below 2 W, and devices were tested for over 2.5 million revolutions without failure. Retainer rings are commonly used in macro-scale bearings to ensure uniform spacing between the rolling elements. The integration of retainers into micro-bearings could lower costs by reducing the number of balls required for stable operation, and also open up the possibility of 'smart' bearings with integrated sensors to monitor the bearing status. C1 [Hergert, Robert J.; Holmes, Andrew S.] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London SW7 2AZ, England. [Hanrahan, Brendan; Ghodssi, Reza] Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA. [Hanrahan, Brendan] USA, Res Lab, Adelphi, MD USA. RP Holmes, AS (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, Exhibit Rd, London SW7 2AZ, England. EM a.holmes@imperial.ac.uk NR 21 TC 3 Z9 3 U1 0 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 EI 1361-6439 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD JUN PY 2013 VL 23 IS 6 AR 065033 DI 10.1088/0960-1317/23/6/065033 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 151HM UT WOS:000319451300033 ER PT J AU Lazarus, N Meyer, CD Bedair, SS Song, X Boteler, LM Kierzewski, IM AF Lazarus, N. Meyer, C. D. Bedair, S. S. Song, X. Boteler, L. M. Kierzewski, I. M. TI Thick film oxidation of copper in an electroplated MEMS process SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID OXIDE FILMS; WAFER; CU; BEHAVIOR AB Copper forms a porous oxide, allowing the formation of oxide layers up to tens of microns thick to be created at modest processing temperatures. In this work, the controlled oxidation of copper is employed within an all-metal electroplating process to create electrically insulating, structural posts and beams. This capability could eliminate the additional dielectric deposition and patterning steps that are often needed during the construction of sensors, waveguides, and other microfabricated devices. In this paper, copper oxidation rates for thermal and plasma-assisted growth methods are characterized. Time control of the oxide growth enables larger copper structures to remain conductive while smaller copper posts are fully oxidized. The concept is demonstrated using the controlled oxidation of a copper layer between two nickel layers to fabricate nickel inductors having both copper electrical vias and copper oxide support pillars. Nickel was utilized in this demonstration for its resistance against low temperature oxidation and interdiffusion with copper. C1 [Lazarus, N.] USA, Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. [Meyer, C. D.; Bedair, S. S.; Boteler, L. M.; Kierzewski, I. M.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Song, X.] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. RP Lazarus, N (reprint author), USA, Res Lab, Oak Ridge Associated Univ Fellowship Program, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.ctr@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX This work was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 38 TC 1 Z9 1 U1 3 U2 24 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD JUN PY 2013 VL 23 IS 6 AR 065017 DI 10.1088/0960-1317/23/6/065017 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 151HM UT WOS:000319451300017 ER PT J AU Lendvay, TS Brand, TC White, L Kowalewski, T Jonnadula, S Mercer, LD Khorsand, D Andros, J Hannaford, B Satava, RM AF Lendvay, Thomas S. Brand, Timothy C. White, Lee Kowalewski, Timothy Jonnadula, Saikiran Mercer, Laina D. Khorsand, Derek Andros, Justin Hannaford, Blake Satava, Richard M. TI Virtual Reality Robotic Surgery Warm-Up Improves Task Performance in a Dry Laboratory Environment: A Prospective Randomized Controlled Study SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID LAPAROSCOPIC RENAL SURGERY; OPERATING-ROOM; SKILLS; SIMULATOR; FUNDAMENTALS; ACQUISITION; VALIDATION; DECREMENT; EDUCATION AB BACKGROUND: Preoperative simulation warm-up has been shown to improve performance and reduce errors in novice and experienced surgeons, yet existing studies have only investigated conventional laparoscopy. We hypothesized that a brief virtual reality (VR) robotic warm-up would enhance robotic task performance and reduce errors. STUDY DESIGN: In a 2-center randomized trial, 51 residents and experienced minimally invasive surgery faculty in General Surgery, Urology, and Gynecology underwent a validated robotic surgery proficiency curriculum on a VR robotic simulator and on the da Vinci surgical robot (Intuitive Surgical Inc). Once they successfully achieved performance benchmarks, surgeons were randomized to either receive a 3- to 5-minute VR simulator warm-up or read a leisure book for 10 minutes before performing similar and dissimilar (intracorporeal suturing) robotic surgery tasks. The primary outcomes compared were task time, tool path length, economy of motion, technical, and cognitive errors. RESULTS: Task time (-29.29 seconds, p = 0.001; 95% CI, -47.03 to -11.56), path length (-79.87 mm; p = 0.014; 95% CI, - 144.48 to - 15.25), and cognitive errors were reduced in the warm-up group compared with the control group for similar tasks. Global technical errors in intracorporeal suturing (0.32; p = 0.020; 95% CI, 0.06 - 0.59) were reduced after the dissimilar VR task. When surgeons were stratified by earlier robotic and laparoscopic clinical experience, the more experienced surgeons (n = 17) demonstrated significant improvements from warm-up in task time (- 53.5 seconds; p = 0.001; 95% CI, - 83.9 to - 23.0) and economy of motion (0.63 mm/s; p = 0.007; 95% CI, 0.18-1.09), and improvement in these metrics was not statistically significantly appreciated in the less-experienced cohort (n = 34). CONCLUSIONS: We observed significant performance improvement and error reduction rates among surgeons of varying experience after VR warm-up for basic robotic surgery tasks. In addition, the VR warm-up reduced errors on a more complex task (robotic suturing), suggesting the generalizability of the warm-up. (J Am Coll Surg 2013; 216: 1181-1192. (C) 2013 by the American College of Surgeons) C1 [Lendvay, Thomas S.] Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA. [Jonnadula, Saikiran; Khorsand, Derek; Andros, Justin; Satava, Richard M.] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA. [White, Lee] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA. [Kowalewski, Timothy; Hannaford, Blake] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA. [Mercer, Laina D.] Seattle Childrens Res Inst, Core Biomed Stat, Seattle, WA USA. [Brand, Timothy C.] USA, Madigan Army Med Ctr, Tacoma, WA USA. RP Lendvay, TS (reprint author), Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA. EM thomas.lendvay@seattlechildrens.org RI Kowalewski, Timothy/C-1391-2014 OI Kowalewski, Timothy/0000-0001-6596-3324 FU Department of Defense US Army Medical Research and Materiel Command [W81XWH-09-1-0714]; Center for Clinical and Translational Research at Seattle Children's Research Institute; NIH National Center for Research Resources [UL1RR025014] FX This study was supported by the Department of Defense US Army Medical Research and Materiel Command under award number W81XWH-09-1-0714 (principal investigator: Lendvay). The views, opinions, and endorsement by the author(s) do not reflect those of the US Army or the Department of Defense.; The Seattle Children's Core for Biomedical Statistics is supported by the Center for Clinical and Translational Research at Seattle Children's Research Institute and grant UL1RR025014 from the NIH National Center for Research Resources. NR 39 TC 29 Z9 29 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JUN PY 2013 VL 216 IS 6 BP 1181 EP 1192 DI 10.1016/j.jamcollsurg.2013.02.012 PG 12 WC Surgery SC Surgery GA 145TG UT WOS:000319039900020 PM 23583618 ER PT J AU Miotto, O Almagro-Garcia, J Manske, M MacInnis, B Campino, S Rockett, KA Amaratunga, C Lim, P Suon, S Sreng, S Anderson, JM Duong, S Nguon, C Chuor, CM Saunders, D Se, Y Lon, C Fukuda, MM Amenga-Etego, L Hodgson, AVO Asoala, V Imwong, M Takala-Harrison, S Nosten, F Su, XZ Ringwald, P Ariey, F Dolecek, C Hien, TT Boni, MF Thai, CQ Amambua-Ngwa, A Conway, DJ Djimde, AA Doumbo, OK Zongo, I Ouedraogo, JB Alcock, D Drury, E Auburn, S Koch, O Sanders, M Hubbart, C Maslen, G Ruano-Rubio, V Jyothi, D Miles, A O'Brien, J Gamble, C Oyola, SO Rayner, JC Newbold, CI Berriman, M Spencer, CCA McVean, G Day, NP White, NJ Bethell, D Dondorp, AM Plowe, CV Fairhurst, RM Kwiatkowski, DP AF Miotto, Olivo Almagro-Garcia, Jacob Manske, Magnus MacInnis, Bronwyn Campino, Susana Rockett, Kirk A. Amaratunga, Chanaki Lim, Pharath Suon, Seila Sreng, Sokunthea Anderson, Jennifer M. Duong, Socheat Nguon, Chea Chuor, Char Meng Saunders, David Se, Youry Lon, Chantap Fukuda, Mark M. Amenga-Etego, Lucas Hodgson, Abraham V. O. Asoala, Victor Imwong, Mallika Takala-Harrison, Shannon Nosten, Francois Su, Xin-zhuan Ringwald, Pascal Ariey, Frederic Dolecek, Christiane Tran Tinh Hien Boni, Maciej F. Cao Quang Thai Amambua-Ngwa, Alfred Conway, David J. Djimde, Abdoulaye A. Doumbo, Ogobara K. Zongo, Issaka Ouedraogo, Jean-Bosco Alcock, Daniel Drury, Eleanor Auburn, Sarah Koch, Oliver Sanders, Mandy Hubbart, Christina Maslen, Gareth Ruano-Rubio, Valentin Jyothi, Dushyanth Miles, Alistair O'Brien, John Gamble, Chris Oyola, Samuel O. Rayner, Julian C. Newbold, Chris I. Berriman, Matthew Spencer, Chris C. A. McVean, Gilean Day, Nicholas P. White, Nicholas J. Bethell, Delia Dondorp, Arjen M. Plowe, Christopher V. Fairhurst, Rick M. Kwiatkowski, Dominic P. TI Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia SO NATURE GENETICS LA English DT Article ID PARASITE CLEARANCE RATE; CHLOROQUINE RESISTANCE; WESTERN CAMBODIA; DRUG-RESISTANCE; DIHYDROPTEROATE SYNTHASE; DIHYDROFOLATE-REDUCTASE; MALARIA PARASITES; SPREAD; PYRIMETHAMINE; GENOME AB We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination. C1 [Miotto, Olivo; Almagro-Garcia, Jacob; Rockett, Kirk A.; Amenga-Etego, Lucas; Koch, Oliver; Miles, Alistair; Newbold, Chris I.; Spencer, Chris C. A.; Kwiatkowski, Dominic P.] Univ Oxford, MRC, Ctr Genom & Global Hlth, Oxford, England. [Miotto, Olivo; Imwong, Mallika; Nosten, Francois; Day, Nicholas P.; White, Nicholas J.; Dondorp, Arjen M.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand. [Miotto, Olivo; Almagro-Garcia, Jacob; Manske, Magnus; MacInnis, Bronwyn; Campino, Susana; Rockett, Kirk A.; Alcock, Daniel; Drury, Eleanor; Sanders, Mandy; Maslen, Gareth; Ruano-Rubio, Valentin; Jyothi, Dushyanth; Oyola, Samuel O.; Rayner, Julian C.; Newbold, Chris I.; Berriman, Matthew; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Cambridge, England. [Almagro-Garcia, Jacob; Rockett, Kirk A.; Hubbart, Christina; Ruano-Rubio, Valentin; Miles, Alistair; O'Brien, John; Spencer, Chris C. A.; McVean, Gilean; Kwiatkowski, Dominic P.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. [Amaratunga, Chanaki; Lim, Pharath; Anderson, Jennifer M.; Su, Xin-zhuan; Fairhurst, Rick M.] NIAID, US Natl Inst Hlth, Bethesda, MD 20892 USA. [Lim, Pharath; Suon, Seila; Sreng, Sokunthea; Duong, Socheat; Nguon, Chea; Chuor, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Saunders, David; Fukuda, Mark M.; Bethell, Delia] US Army Med Component, Armed Forces Res Inst Med Sci USAMC AFRIMS, Dept Immunol & Med, Bangkok, Thailand. [Se, Youry; Lon, Chantap] USAMC AFRIMS, Phnom Penh, Cambodia. [Fukuda, Mark M.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Amenga-Etego, Lucas; Hodgson, Abraham V. O.; Asoala, Victor] Navrongo Hlth Res Ctr, Navrongo, Ghana. [Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand. [Takala-Harrison, Shannon; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot, Tak, Thailand. [Nosten, Francois; Dolecek, Christiane; Tran Tinh Hien; Boni, Maciej F.; Day, Nicholas P.; White, Nicholas J.; Dondorp, Arjen M.] Univ Oxford, Ctr Trop Med, Oxford, England. [Ringwald, Pascal] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland. [Ariey, Frederic] Inst Pasteur, Unite Immunol Mol Parasites, Paris, France. [Dolecek, Christiane; Tran Tinh Hien; Boni, Maciej F.; Cao Quang Thai] Oxford Univ Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. [Amambua-Ngwa, Alfred; Conway, David J.] MRC Labs, Fajara, Gambia. [Conway, David J.] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England. [Djimde, Abdoulaye A.; Doumbo, Ogobara K.] Univ Sci Tech & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Bamako, Mali. [Zongo, Issaka; Ouedraogo, Jean-Bosco] Direct Reg Ouest, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso. [Auburn, Sarah] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia. [Gamble, Chris] Univ Oxford, Dept Stat, Oxford OX1 3TG, England. [Newbold, Chris I.] Univ Oxford, Weatherall Inst Mol Med, Oxford, England. RP Kwiatkowski, DP (reprint author), Univ Oxford, MRC, Ctr Genom & Global Hlth, Oxford, England. EM dominic@sanger.ac.uk RI Valle, Ruben/A-7512-2013; Koch, Oliver/A-9480-2016; Jyothi, Dushyanth/H-9517-2014; OI Mead, Daniel/0000-0001-7717-4330; Manske, Magnus/0000-0001-5916-0947; Nosten, Francois/0000-0002-7951-0745; Oyola, Samuel O./0000-0002-6425-7345; Rayner, Julian/0000-0002-9835-1014; Su, Xinzhuan/0000-0003-3246-3248; Auburn, Sarah/0000-0002-4638-536X; Jyothi, Dushyanth/0000-0002-0448-5303; McVean, Gil/0000-0002-5012-4162; Newbold, Chris/0000-0002-9274-3789; Conway, David/0000-0002-8711-3037; Miotto, Olivo/0000-0001-8060-6771; Kwiatkowski, Dominic/0000-0002-5023-0176 FU Wellcome Trust through core funding of the Wellcome Trust Sanger Institute [098051]; Wellcome Trust through core funding of the Wellcome Trust Centre for Human Genetics [090532/Z/09/Z]; Wellcome Trust through a Strategic Award [090770/Z/09/Z]; MRC through the MRC Centre for Genomics and Global Health [G0600718]; MRC through an MRC Professorship [G19/9]; Wellcome Trust; MRC; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, US National Institutes of Health; Howard Hughes Medical Institute International Scholarship [55005502] FX We would like to thank V. Cornelius and R. Giacomantonio for their support in producing and reviewing this manuscript; S. Uk and E.S. Phelps for their contributions in the Cambodian studies; and T. Anderson for helpful review comments. The sequencing, genotyping and analysis components of this study were supported by the Wellcome Trust through core funding of the Wellcome Trust Sanger Institute (098051), core funding of the Wellcome Trust Centre for Human Genetics (090532/Z/09/Z) and a Strategic Award (090770/Z/09/Z) and the MRC through the MRC Centre for Genomics and Global Health (G0600718) and an MRC Professorship to D.P.K. (G19/9). Other parts of this study were partly supported by the Wellcome Trust; the MRC; the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, US National Institutes of Health; and a Howard Hughes Medical Institute International Scholarship (55005502) to A.A.D. P.R. is a staff member of the World Health Organization; he alone is responsible for the views expressed in this publication, and they do not necessarily represent the decisions, policy or views of the World Health Organization. NR 45 TC 183 Z9 186 U1 5 U2 65 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1061-4036 EI 1546-1718 J9 NAT GENET JI Nature Genet. PD JUN PY 2013 VL 45 IS 6 BP 648 EP + DI 10.1038/ng.2624 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 152XA UT WOS:000319563900012 PM 23624527 ER PT J AU Chung, CC Kanetsky, PA Wang, ZM Hildebrandt, MAT Koster, R Skotheim, RI Kratz, CP Turnbull, C Cortessis, VK Bakken, AC Bishop, DT Cook, MB Erickson, RL Fossa, SD Jacobs, KB Korde, LA Kraggerud, SM Lothe, RA Loud, JT Rahman, N Skinner, EC Thomas, DC Wu, XF Yeager, M Schumacher, FR Greene, MH Schwartz, SM McGlynn, KA Chanock, SJ Nathanson, KL AF Chung, Charles C. Kanetsky, Peter A. Wang, Zhaoming Hildebrandt, Michelle A. T. Koster, Roelof Skotheim, Rolf I. Kratz, Christian P. Turnbull, Clare Cortessis, Victoria K. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fossa, Sophie D. Jacobs, Kevin B. Korde, Larissa A. Kraggerud, Sigrid M. Lothe, Ragnhild A. Loud, Jennifer T. Rahman, Nazneen Skinner, Eila C. Thomas, Duncan C. Wu, Xifeng Yeager, Meredith Schumacher, Fredrick R. Greene, Mark H. Schwartz, Stephen M. McGlynn, Katherine A. Chanock, Stephen J. Nathanson, Katherine L. TI Meta-analysis identifies four new loci associated with testicular germ cell tumor SO NATURE GENETICS LA English DT Article ID GENOME-WIDE ASSOCIATION; MIXED LINEAGE KINASE; MULIBREY NANISM; MARIJUANA USE; RECOMBINATION HOTSPOTS; LINKAGE DISEQUILIBRIUM; CANCER-PATIENTS; OVARIAN-CANCER; DOMAIN-LIKE; DNA-DAMAGE AB We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor (TGCT). In the discovery phase, we analyzed 931 affected individuals and 1,975 controls from 3 genome-wide association studies (GWAS). We conducted replication in 6 independent sample sets comprising 3,211 affected individuals and 7,591 controls. In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26; P = 1.11 x 10(-8)), 7p22.3 in MAD1L1 (OR = 1.21, 95% CI = 1.14-1.29; P = 5.59 x 10(-9)), 16q22.3 in RFWD3 (OR = 1.26, 95% CI = 1.18-1.34; P = 5.15 x 10(-12)) and 17q22 (rs9905704: OR = 1.27, 95% CI = 1.18-1.33; P = 4.32 x 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 x 10(-9)), a locus that includes TEX14, RAD51C and PPM1E. These new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and the DNA damage response. C1 [Chung, Charles C.; Wang, Zhaoming; Kratz, Christian P.; Cook, Michael B.; Jacobs, Kevin B.; Korde, Larissa A.; Loud, Jennifer T.; Yeager, Meredith; Greene, Mark H.; McGlynn, Katherine A.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, US Natl Inst Hlth, US Dept HHS, Bethesda, MD 20892 USA. [Chung, Charles C.; Wang, Zhaoming; Jacobs, Kevin B.; Yeager, Meredith] NCI Frederick, Canc Genome Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick, Frederick, MD USA. [Kanetsky, Peter A.; Nathanson, Katherine L.] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Kanetsky, Peter A.] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA. [Hildebrandt, Michelle A. T.; Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Koster, Roelof; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Dept Med Translat Med & Human Genet, Philadelphia, PA 19104 USA. [Skotheim, Rolf I.; Bakken, Anne C.; Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Oslo Univ Hosp, Inst Canc Res, Dept Canc Prevent, Norwegian Radium Hosp, Oslo, Norway. [Skotheim, Rolf I.; Bakken, Anne C.; Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Univ Oslo, Fac Med, Ctr Canc Biomed, Oslo, Norway. [Turnbull, Clare; Rahman, Nazneen] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England. [Cortessis, Victoria K.; Thomas, Duncan C.; Schumacher, Fredrick R.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA. [Bishop, D. Timothy] St James Univ Hosp, Leeds Inst Mol Med, Sect Epidemiol & Biostat, Canc Res UK Clin Ctr Leeds, Leeds, W Yorkshire, England. [Erickson, R. Loren] Walter Reed Army Inst Res, Silver Spring, MD USA. [Fossa, Sophie D.] Univ Oslo, Dept Oncol, Norwegian Radium Hosp, Oslo Univ Hosp, Oslo, Norway. [Korde, Larissa A.] Univ Washington, Div Med Oncol, Seattle Canc Care Alliance, Seattle, WA 98195 USA. [Skinner, Eila C.] Stanford Univ, Dept Urol, Stanford, CA 94305 USA. [Schwartz, Stephen M.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Schwartz, Stephen M.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. RP Nathanson, KL (reprint author), Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA. EM knathans@exchange.upenn.edu RI Cook, Michael/A-5641-2009; Koster, Roelof/E-2158-2016; OI Cook, Michael/0000-0002-0533-7302; Koster, Roelof/0000-0003-1424-8579; Schwartz, Stephen/0000-0001-7499-8502; Nathanson, Katherine/0000-0002-6740-0901; Bishop, Tim/0000-0002-8752-8785 FU Intramural Research Program of the NCI; Westat, Inc. [HHSN261200655004C]; Abramson Cancer Center at the University of Pennsylvania; US National Institutes of Health grant [R01CA114478, R01CA085914]; Multiethnic Cohort Study [NCI U01-CA98758]; California Cancer Research Program [99-00505V-10260, 03-00174VRS-30021]; NCI grant [R01CA102042]; Whittier Foundation; Center for Translational and Public Health Genomics of the Duncan Family Institute for Cancer Prevention and Risk Assessment; MD Anderson Senior Research Trust Fellowship; Institute of Cancer Research; Wellcome Trust; Norwegian Cancer Society; Health Region South-Eastern Norway; Norwegian ExtraFoundation for Health and Rehabilitation; Cancer Research UK FX A portion of this work was supported by the Intramural Research Program of the NCI and by support services contract HHSN261200655004C with Westat, Inc. The Penn GWAS (UPENN) and replication effort for the TestPAC study were supported by the Abramson Cancer Center at the University of Pennsylvania and US National Institutes of Health grant R01CA114478 to P.A.K. and K.L.N. The replication effort for the ATLAS study was supported by US National Institutes of Health grant R01CA085914 to S.M.S. The analysis of the USC GWAS controls was supported by the Multiethnic Cohort Study (NCI U01-CA98758). The analyses of the USC GWAS testicular cases and the Familial Study were supported by the California Cancer Research Program (99-00505V-10260 and 03-00174VRS-30021) and by an NCI grant (R01CA102042) to V.K.C. and a Whittier Foundation award to the Norris Comprehensive Cancer Center. The study at MD Anderson was supported by the Center for Translational and Public Health Genomics of the Duncan Family Institute for Cancer Prevention and Risk Assessment and by an MD Anderson Senior Research Trust Fellowship to X.W. The UK testicular cancer study was supported by the Institute of Cancer Research, Cancer Research UK and the Wellcome Trust and made use of control data generated by the Wellcome Trust Case Control Consortium 2 (WTCCC2). Support was provided by the Norwegian Cancer Society to R.A.L. and R.I.S., by Health Region South-Eastern Norway to R.A.L. and S.D.F., and by the Norwegian ExtraFoundation for Health and Rehabilitation to S.D.F. NR 70 TC 61 Z9 62 U1 1 U2 17 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1061-4036 J9 NAT GENET JI Nature Genet. PD JUN PY 2013 VL 45 IS 6 BP 680 EP + DI 10.1038/ng.2634 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 152XA UT WOS:000319563900017 PM 23666239 ER PT J AU Gribok, A Hoyt, R Buller, M Rumpler, W AF Gribok, Andrei Hoyt, Reed Buller, Mark Rumpler, William TI On the accuracy of instantaneous gas exchange rates, energy expenditure and respiratory quotient calculations obtained from indirect whole room calorimetry SO PHYSIOLOGICAL MEASUREMENT LA English DT Article; Proceedings Paper CT 13th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) CY MAY 23-25, 2012 CL Tianjin, PEOPLES R CHINA DE indirect calorimetry; uncertainty; regularization ID BODY INDIRECT CALORIMETER; TRANSIENT-RESPONSE; DECONVOLUTION; CHAMBER AB This paper analyzes the accuracy of metabolic rate calculations performed in the whole room indirect calorimeter using the molar balance equations. The equations are treated from the point of view of cause-effect relationship where the gaseous exchange rates representing the unknown causes need to be inferred from a known, noisy effect-gaseous concentrations. Two methods of such inference are analyzed. The first method is based on the previously published regularized deconvolution of the molar balance equation and the second one, proposed in this paper, relies on regularized differentiation of gaseous concentrations. It is found that both methods produce similar results for the absolute values of metabolic variables and their accuracy. The uncertainty for O-2 consumption rate is found to be 7% and for CO2 production-3.2%. The uncertainties in gaseous exchange rates do not depend on the absolute values of O-2 consumption and CO2 production. In contrast, the absolute uncertainty in respiratory quotient is a function of the gaseous exchange rates and varies from 9.4% during the night to 2.3% during moderate exercise. The uncertainty in energy expenditure was found to be 5.9% and independent of the level of gaseous exchange. For both methods, closed form analytical formulas for confidence intervals are provided allowing quantification of uncertainty for four major metabolic variables in real world studies. C1 [Gribok, Andrei; Rumpler, William] ARS, Food Components & Hlth Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA. [Hoyt, Reed; Buller, Mark] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Gribok, A (reprint author), ARS, Food Components & Hlth Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA. EM agribok@utk.edu NR 22 TC 1 Z9 1 U1 1 U2 12 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0967-3334 EI 1361-6579 J9 PHYSIOL MEAS JI Physiol. Meas. PD JUN PY 2013 VL 34 IS 6 BP 737 EP 755 DI 10.1088/0967-3334/34/6/737 PG 19 WC Biophysics; Engineering, Biomedical; Physiology SC Biophysics; Engineering; Physiology GA 152WS UT WOS:000319563000013 PM 23719329 ER PT J AU Porter, MD Nicki, J Pool, CD DeBot, M Illam, RM Brando, C Bozick, B De La Vega, P Angra, D Spaccapelo, R Crisanti, A Murphy, JR Bennett, JW Schwenk, RJ Ockenhouse, CF Dutta, S AF Porter, Michael D. Nicki, Jennifer Pool, Christopher D. DeBot, Margot Illam, Ratish M. Brando, Clara Bozick, Brooke De La Vega, Patricia Angra, Divya Spaccapelo, Roberta Crisanti, Andrea Murphy, Jittawadee R. Bennett, Jason W. Schwenk, Robert J. Ockenhouse, Christian F. Dutta, Sheetij TI Transgenic Parasites Stably Expressing Full-Length Plasmodium falciparum Circumsporozoite Protein as a Model for Vaccine Down-Selection in Mice Using Sterile Protection as an Endpoint SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID MALARIA VACCINES; AOTUS MONKEYS; SPOROZOITES; IMMUNITY; STRAIN; EFFICACY; INVASION; ELICITS; SAFETY AB Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria vaccine candidate. There is an urgent need for models that can rapidly down-select novel CSP-based vaccine candidates. In the present study, the mouse-mosquito transmission cycle of a transgenic Plasmodium berghei malaria parasite stably expressing a functional full-length P. falciparum CSP was optimized to consistently produce infective sporozoites for protection studies. A minimal sporozoite challenge dose was established, and protection was defined as the absence of blood-stage parasites 14 days after intravenous challenge. The specificity of protection was confirmed by vaccinating mice with multiple CSP constructs of differing lengths and compositions. Constructs that induced high NANP repeat-specific antibody titers in enzyme-linked immunosorbent assays were protective, and the degree of protection was dependent on the antigen dose. There was a positive correlation between antibody avidity and protection. The antibodies in the protected mice recognized the native CSP on the parasites and showed sporozoite invasion inhibitory activity. Passive transfer of anti-CSP antibodies into naive mice also induced protection. Thus, we have demonstrated the utility of a mouse efficacy model to down-select human CSP-based vaccine formulations. C1 [Porter, Michael D.; Nicki, Jennifer; Pool, Christopher D.; DeBot, Margot; Illam, Ratish M.; De La Vega, Patricia; Angra, Divya; Bennett, Jason W.; Schwenk, Robert J.; Ockenhouse, Christian F.; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Dev Branch, Silver Spring, MD USA. [Brando, Clara; Bozick, Brooke; Murphy, Jittawadee R.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Spaccapelo, Roberta] Univ Perugia, I-06100 Perugia, Italy. [Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Dev Branch, Silver Spring, MD USA. EM sheetij.dutta@us.army.mil RI Bennett, Jason/B-3547-2011 FU USAID Malaria Vaccine Development Program FX The funding for this work was provided by the USAID Malaria Vaccine Development Program. NR 24 TC 14 Z9 14 U1 1 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2013 VL 20 IS 6 BP 803 EP 810 DI 10.1128/CVI.00066-13 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 151HO UT WOS:000319451500005 PM 23536694 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI Does the sulfur cathode require good mixing for a liquid electrolyte lithium/sulfur cell? SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE Lithium/sulfur cell; Sulfur cathode; Liquid electrolyte; Polysulfide; Ac impedance ID GRAPHITE-ELECTRODES; BATTERIES; INTERCALATION; IMPEDANCE; IONS AB In order to demonstrate whether the sulfur cathode of a liquid electrolyte lithium/sulfur (Li/S) cell requires good mixing, we intentionally prepare the following three cathodes: (1) Cathode A made by spreading a sulfur/carbon disulfide solution onto a porous carbon electrode, (2) Cathode B made by laminating a porous carbon layer and a pure sulfur layer together, and (3) Cathode C made by soaking a carbon cloth into a sulfur/carbon disulfide solution and then evaporating the solvent. Without any milling treatments, the large yellow sulfur particles/crystals are visually visible in all three cathodes. Even using these cathodes without mixing of the sulfur and conducting carbon, the Li/S cells still exhibit initial discharge capacities of 1218, 1337, and 966 mAh g(-1) for Cathodes A, B, C, respectively, and maintain comparable capacity retentions as compared with the conventional Li/S cells. These results reveal that the initial mixing status of the cathode does not affect the cycling performance of Li/S cells. In this paper, we discuss our results from the viewpoint of the Li/S fundamental chemistry and suggest more effective approaches for the performance improvement. Published by Elsevier B.V. C1 USA, Res Lab, Electrochem Branch, RDRL SED C Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Electrochem Branch, RDRL SED C Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 13 TC 28 Z9 28 U1 10 U2 169 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD JUN PY 2013 VL 31 BP 10 EP 12 DI 10.1016/j.elecom.2013.02.021 PG 3 WC Electrochemistry SC Electrochemistry GA 148IA UT WOS:000319236800003 ER PT J AU Da, DF Dixit, S Sattabonkot, J Mu, JB Abate, L Ramineni, B Ouedraogo, JB MacDonald, NJ Fay, MP Su, XZ Cohuet, A Wu, YM AF Da, Dari F. Dixit, Saurabh Sattabonkot, Jetsumon Mu, Jianbing Abate, Luc Ramineni, Bhanumati Ouedraogo, Jean Bosco MacDonald, Nicholas J. Fay, Michael P. Su, Xin-zhuan Cohuet, Anna Wu, Yimin TI Anti-Pfs25 Human Plasma Reduces Transmission of Plasmodium falciparum Isolates That Have Diverse Genetic Backgrounds SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA TRANSMISSION; VACCINE CANDIDATE; BLOCKING VACCINE; SEXUAL STAGE; INFECTIONS; ANTIGENS; POPULATIONS; TESTS AB Pfs25 is a leading candidate for a malaria transmission-blocking vaccine whose potential has been demonstrated in a phase 1 trial with recombinant Pfs25 formulated with Montanide ISA51. Because of limited sequence polymorphism, the anti-Pfs25 antibodies induced by this vaccine are likely to have transmission-blocking or -reducing activity against most, if not all, field isolates. To test this hypothesis, we evaluated transmission-blocking activities by membrane feeding assay of anti-Pfs25 plasma from the Pfs25/ISA51 phase 1 trial against Plasmodium falciparum parasites from patients in two different geographical regions of the world, Thailand and Burkina Faso. In parallel, parasite isolates from these patients were sequenced for the Pfs25 gene and genotyped for seven microsatellites. The results indicate that despite different genetic backgrounds among parasite isolates, the Pfs25 sequences are highly conserved, with a single nonsynonymous nucleotide polymorphism detected in 1 of 41 patients in Thailand and Burkina Faso. The anti-Pfs25 immune plasma had significantly higher transmission-reducing activity against parasite isolates from the two geographical regions than the nonimmune controls (P < 0.0001). C1 [Da, Dari F.; Ouedraogo, Jean Bosco; Cohuet, Anna] IRSS, Bobo Dioulasso, Burkina Faso. [Da, Dari F.; Abate, Luc; Cohuet, Anna] UMR MIVEGEC UM1 UM2 CNRS 5290 IRD 224, IRD, Montpellier, France. [Dixit, Saurabh; Ramineni, Bhanumati; MacDonald, Nicholas J.; Wu, Yimin] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD USA. [Sattabonkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Mu, Jianbing; Su, Xin-zhuan] NIAID, Lab Malaria & Vector Res, Rockville, MD USA. [Fay, Michael P.] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. RP Wu, YM (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD USA. EM yiwu@niaid.nih.gov RI Cohuet, Anna/B-2745-2017; OI Cohuet, Anna/0000-0002-1876-5656; Fay, Michael P./0000-0002-8643-9625; Su, Xinzhuan/0000-0003-3246-3248 FU Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States; European Community's Seventh Framework Program (FP7) [242095, 223736]; IRD FX This work was supported by funding from the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States, and the European Community's Seventh Framework Program (FP7/2007-2013) under grant agreements 242095 and 223736. Also, we thank IRD for financial support and for a fellowship to D.F.D. NR 23 TC 7 Z9 7 U1 1 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 2013 VL 81 IS 6 BP 1984 EP 1989 DI 10.1128/IAI.00016-13 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 143GN UT WOS:000318855100012 PM 23509152 ER PT J AU Jepsen, KJ Evans, R Negus, CH Gagnier, JJ Centi, A Erlich, T Hadid, A Yanovich, R Moran, DS AF Jepsen, Karl J. Evans, Rachel Negus, Charles H. Gagnier, Joel J. Centi, Amanda Erlich, Tomer Hadid, Amir Yanovich, Ran Moran, Daniel S. TI Variation in tibial functionality and fracture susceptibility among healthy, young adults arises from the acquisition of biologically distinct sets of traits SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Article DE FUNCTIONAL ADAPTATION; STRESS FRACTURES; BIOMECHANICS; TIBIA; ADULT ID STRESS-FRACTURE; BONE STRENGTH; STRUCTURAL GEOMETRY; SEXUAL-DIMORPHISM; HIP FRACTURE; ELDERLY-MEN; GROWTH; RECRUITS; FRAGILITY; WOMEN AB Physiological systems like bone respond to many genetic and environmental factors by adjusting traits in a highly coordinated, compensatory manner to establish organ-level function. To be mechanically functional, a bone should be sufficiently stiff and strong to support physiological loads. Factors impairing this process are expected to compromise strength and increase fracture risk. We tested the hypotheses that individuals with reduced stiffness relative to body size will show an increased risk of fracturing and that reduced strength arises from the acquisition of biologically distinct sets of traits (ie, different combinations of morphological and tissue-level mechanical properties). We assessed tibial functionality retrospectively for 336 young adult women and men engaged in military training, and calculated robustness (total area/bone length), cortical area (Ct.Ar), and tissue-mineral density (TMD). These three traits explained 69% to 72% of the variation in tibial stiffness (p<0.0001). Having reduced stiffness relative to body size (body weightxbone length) was associated with odds ratios of 1.5 (95% confidence interval [CI], 0.54.3) and 7.0 (95% CI, 2.025.1) for women and men, respectively, for developing a stress fracture based on radiography and scintigraphy. K-means cluster analysis was used to segregate men and women into subgroups based on robustness, Ct.Ar, and TMD adjusted for body size. Stiffness varied 37% to 42% among the clusters (p<0.0001, ANOVA). For men, 78% of stress fracture cases segregated to three clusters (p<0.03, chi-square). Clusters showing reduced function exhibited either slender tibias with the expected Ct.Ar and TMD relative to body size and robustness (ie, well-adapted bones) or robust tibias with reduced residuals for Ct.Ar or TMD relative to body size and robustness (ie, poorly adapted bones). Thus, we show there are multiple biomechanical and thus biological pathways leading to reduced function and increased fracture risk. Our results have important implications for developing personalized preventative diagnostics and treatments. C1 [Jepsen, Karl J.; Gagnier, Joel J.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA. [Evans, Rachel; Centi, Amanda] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Negus, Charles H.] L 3 Jaycor, San Diego, CA USA. [Erlich, Tomer; Hadid, Amir; Yanovich, Ran; Moran, Daniel S.] Ariel Univ, Sheba Med Ctr, Heller Inst, Ariel, Israel. RP Jepsen, KJ (reprint author), Univ Michigan, Dept Orthopaed Surg, Room 2007,Biomed Sci Res Bldg,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA. EM kjepsen@umich.edu FU U.S. Department of Defense [W81XWH-09-2-0113, W81XWH-07-C-0097]; medical research and material command (MRMC) Bone Health Grant FX This work was supported by grants from the U.S. Department of Defense (W81XWH-09-2-0113, W81XWH-07-C-0097) and an medical research and material command (MRMC) Bone Health Grant. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the Department of Defense. NR 37 TC 12 Z9 12 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD JUN PY 2013 VL 28 IS 6 BP 1290 EP 1300 DI 10.1002/jbmr.1879 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 149VS UT WOS:000319350100007 PM 23362125 ER PT J AU Belenkiy, S Ivey, KM Batchinsky, AI Langer, T Necsoiu, C Baker, W Salinas, J Cancio, LC AF Belenkiy, Slava Ivey, Katherine M. Batchinsky, Andriy I. Langer, Thomas Necsoiu, Corina Baker, William Salinas, Jose Cancio, Leopoldo C. TI NONINVASIVE CARBON DIOXIDE MONITORING IN A PORCINE MODEL OF ACUTE LUNG INJURY DUE TO SMOKE INHALATION AND BURNS SO SHOCK LA English DT Article DE Transcutaneous carbon dioxide; end-tidal carbon dioxide; blood gas analysis; acute lung injury; swine; burns; inhalation injury ID CRITICALLY-ILL; MECHANICAL VENTILATION; TRANSCUTANEOUS PCO2; GENERAL-ANESTHESIA; OXYGEN-SATURATION; PARTIAL-PRESSURE; ADULTS; ACCURACY; TENSION; CAPNOGRAPHY AB In critically ill intubated patients, assessment of adequacy of ventilation relies on measuring partial pressure of arterial carbon dioxide (PaCO2), which requires invasive arterial blood gas analysis. Alternative noninvasive technologies include transcutaneous CO2 (tPCO(2)) and end-tidal CO2 (EtCO2) monitoring. We evaluated accuracy of tPCO(2) and EtCO2 monitoring in a porcine model of acute lung injury (ALI) due to smoke inhalation and burns. Eight anesthetized Yorkshire pigs underwent mechanical ventilation, wood-bark smoke inhalation injury, and 40% total body surface area thermal injury. tPCO(2) was measured with a SenTec system (SenTec AG, Therwil, Switzerland) and EtCO2 with a Capnostream-20 (Oridion Medical, Jerusalem, Israel). These values were compared with PaCO2 measurements from an arterial blood gas analyzer. Paired measurements of EtCO2-PaCO2 (n = 276) and tPCO(2)-PaCO2 (n = 250) were recorded in the PaCO2 range of 25 to 85 mmHg. Overlapping data sets were analyzed based on respiratory and hemodynamic status of animals. Acute lung injury was defined as PaO2/FIO2 <= 300 mmHg; hemodynamic instability was defined as mean arterial pressure <= 60 mmHg. Before ALI, EtCO2 demonstrated moderate correlation with PaCO2 (R-2 = 0.45; P < 0.0001), which deteriorated after onset of ALI (R-2 = 0.12; P < 0.0001). Before ALI, tPCO(2) demonstrated moderate correlation (R-2 = 0.51, P < 0.0001), which was sustained after onset of ALI (R-2 = 0.78; P < 0.0001). During hemodynamic stability, EtCO2 demonstrated moderate correlation with PaCO2 (R-2 = 0.44; P < 0.0001). During hemodynamic instability, EtCO2 did not correlate with PaCO2 (R-2 = 0.03; P = 0.29). tPCO(2) monitoring demonstrated strong correlation with PaCO2 during hemodynamic stability (R-2 = 0.80, P < 0.0001), which deteriorated under hemodynamically unstable conditions (R-2 = 0.39; P < 0.0001). Noninvasive carbon dioxide monitors are acceptable for monitoring trends in PaCO2 under conditions of hemodynamic and pulmonary stability. Under unstable conditions, reevaluation of patient status and increased caution in the interpretation of results are required. C1 [Belenkiy, Slava; Ivey, Katherine M.; Batchinsky, Andriy I.; Langer, Thomas; Necsoiu, Corina; Baker, William; Salinas, Jose; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Belenkiy, Slava; Ivey, Katherine M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Langer, Thomas] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM lee.cancio@us.army.mil FU Oridion, Inc; US Army Institute of Surgical Research; Combat Critical Care Engineering Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research, and Materiel Command FX The authors thank Oridion, Inc, for providing support for this study, under a Cooperative Research and Development Agreement with the US Army Institute of Surgical Research.; This study was funded by the Combat Critical Care Engineering Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research, and Materiel Command. NR 32 TC 10 Z9 10 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2013 VL 39 IS 6 BP 495 EP 500 DI 10.1097/SHK.0b013e318292c331 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 147WL UT WOS:000319200700005 PM 23572088 ER PT J AU McAlpin, TO Sharp, JA Scott, SH Savant, G AF McAlpin, Tate O. Sharp, Jeremy A. Scott, Stephen H. Savant, Gaurav TI Habitat Restoration and Flood Control Protection in the Kissimmee River SO WETLANDS LA English DT Article DE Kissimmee River; Adaptive Hydraulics; AdH; River Restoration ID ECOSYSTEM AB The Adaptive Hydraulics (AdH) code was applied to simulate the hydrodynamic conditions along a stretch of the Kissimmee River in an effort to determine the impacts associated with possible system restoration alternatives. The Kissimmee River Basin flood control project, completed in 1971, had a negative impact on the ecosystem of the Kissimmee River and the adjacent floodplain by reducing floodplain inundation. This numerical model study investigated the expected inundation amounts associated with two restoration alternatives with the first being a return to the historical system and the second being a restored system that would maintain some flood control measures. The model simulations indicate an increase of anywhere from 12 % to 33 % in the floodplain inundation associated with system alternatives when compared to the existing conditions. This indicates that implementation of either of these alternatives would improve the ecosystem productivity for this portion of the Kissimmee River with the restored alternative also providing some flood protection. C1 [McAlpin, Tate O.; Sharp, Jeremy A.; Scott, Stephen H.] USA, Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Savant, Gaurav] Dynam Solut LLC, Coastal & Hydraul Lab, Res Water Resources, USA,Corps Engineers, Vicksburg, MS 39180 USA. RP McAlpin, TO (reprint author), USA, Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Tate.O.McAlpin@usace.army.mil FU U.S. Army Corp of Engineers Jacksonville District FX The work described and results presented in this paper were obtained through research sponsored by the U.S. Army Corp of Engineers Jacksonville District. Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corp of Engineers. The authors would also like to acknowledge the contributions of three anonymous reviewers for comments and suggestions that improved the quality of this manuscript. NR 27 TC 0 Z9 0 U1 2 U2 39 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 2013 VL 33 IS 3 BP 551 EP 560 DI 10.1007/s13157-013-0412-2 PG 10 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 142LC UT WOS:000318797900015 ER PT J AU Taylor, GS Barnett, JS AF Taylor, Grant S. Barnett, John S. TI Evaluation of Wearable Simulation Interface for Military Training SO HUMAN FACTORS LA English DT Article DE simulator; training; computer interface; usability; training effectiveness; training transfer; wearable simulation interface ID PRESENCE QUESTIONNAIRE; VIRTUAL ENVIRONMENTS AB Objective: This research evaluated the training effectiveness of a novel simulation interface, a wearable computer integrated into a soldier's load-bearing equipment. Background: Military teams often use game-based simulators on desktop computers to train squad-level procedures. A wearable computer interface that mimics the soldier's equipment was expected to provide better training through increased realism and immersion. Method: A heuristic usability evaluation and two experiments were conducted. Eight evaluators interacted with both wearable and desktop interfaces and completed a usability survey. The first experiment compared the training retention of the wearable interface with a desktop simulator and interactive training video. The second experiment compared the training transfer of the wearable and desktop simulators with a live training environment. Results: Results indicated the wearable interface was more difficult to use and elicited stronger symptoms of simulator sickness. There was no significant difference in training retention between the wearable, desktop, or interactive video training methods. The live training used in the second experiment provided superior training transfer than the simulator conditions, with no difference between the desktop and wearable. Conclusion: The wearable simulator interface did not provide better training than the desktop computer interface. It also had poorer usability and caused worse simulator sickness. Therefore, it was a less effective training tool. Application: This research illustrates the importance of conducting empirical evaluations of novel training technologies. New and innovative technologies are always coveted by users, but new does not always guarantee improvement. C1 [Taylor, Grant S.] Univ Cent Florida, Inst Simulat & Training, Appl Cognit & Training Immers Virtual Environm AC, Orlando, FL 32816 USA. [Barnett, John S.] USA, Res Inst Behav & Social Sci, Technol Based Training Unit, Orlando, FL 32826 USA. RP Barnett, JS (reprint author), USA, Res Inst, ATTN DAPE ARI IF, 12350 Res Pkwy, Orlando, FL 32826 USA. EM john.barnett1@us.army.mil NR 28 TC 0 Z9 0 U1 4 U2 21 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD JUN PY 2013 VL 55 IS 3 BP 672 EP 690 DI 10.1177/0018720812466892 PG 19 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 144MF UT WOS:000318942900017 PM 23829039 ER PT J AU Bartone, PT Kelly, DR Matthews, MD AF Bartone, Paul T. Kelly, Dennis R. Matthews, Michael D. TI Psychological Hardiness Predicts Adaptability in Military Leaders: A prospective study SO INTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT LA English DT Article ID 5-FACTOR MODEL; TRANSFORMATIONAL LEADERSHIP; PERSONALITY HARDINESS; ADAPTIVE PERFORMANCE; LIFE EVENTS; HEALTH; STRESS; BEHAVIOR; CADETS; SCALE AB To perform effectively in complex mission environments, security personnel and leaders must be flexible and adaptable in responding to rapidly changing conditions. Psychological hardiness marks resilient people who maintain their health and performance despite stressful situations. The present study evaluates psychological hardiness at entry to West Point military academy as a predictor of leader performance and adaptability over time. Predictors also included Scholastic Aptitude Test (SAT) scores, and a composite indicator of leader potential (Whole Candidate Score) taken from admissions records. Using the Pulakos adaptability taxonomy as a guide, adaptability performance items were taken from a survey of graduates given 3 years after graduation. Also, military leadership grades as West Point seniors provided an index of traditional military performance. Hierarchical regression analyses showed that Whole Candidate Scores predict military leader performance at West Point, but not leader adaptability after graduation. However, hardiness predicts leader performance at West Point, and also leader adaptability (self- and supervisor ratings) after graduation. SAT scores and the challenge facet of hardiness are negative predictors of leader performance at West Point. Results indicate that while the traditional measures Whole Candidate Score predicts leader performance in the stable, highly regulated environment of West Point, it does not predict leader adaptability and performance in the uncertain environment of real-world operations. In contrast, psychological hardiness (commitment and control facets) measured as academy freshmen predicts leader adaptability in officers measured 7 years later. Psychological hardiness appears to be a promising factor in promoting the development of adaptability. C1 [Bartone, Paul T.] Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA. [Kelly, Dennis R.; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA. RP Bartone, PT (reprint author), Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA. EM bartonep@ndu.edu OI Bartone, Paul/0000-0002-5767-0086 NR 77 TC 5 Z9 5 U1 5 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0965-075X EI 1468-2389 J9 INT J SELECT ASSESS JI Int. J. Sel. Assess. PD JUN PY 2013 VL 21 IS 2 BP 200 EP 210 DI 10.1111/ijsa.12029 PG 11 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 145IO UT WOS:000319009000006 ER PT J AU Walberg, FC Stark, TD Nicholson, PJ Castro, G Byrne, PM Axtell, PJ Dillon, JC Empson, WB Topi, JE Mathews, DL Bellew, GM AF Walberg, Francke C. Stark, Timothy D. Nicholson, Peter J. Castro, Gonzalo Byrne, Peter M. Axtell, Paul J. Dillon, John C. Empson, William B. Topi, Joseph E. Mathews, David L. Bellew, Glen M. TI Seismic Retrofit of Tuttle Creek Dam SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article DE Jet grouting; soil mixing; cutoff walls; shear walls; soil mechanics; permeability; liquefaction; earthquake induced displacement; slope stability AB This paper discusses the seismic retrofit of Tuttle Creek Dam near Manhattan, Kansas, including investigations, seismic analyses, design, construction, and stabilization techniques used. Original plans called for stabilization of the upstream and downstream slopes and installation of an upstream cutoff wall to reduce underseepage. However, constructability and dam safety issues, along with the results of refined seismic deformation analyses, led to cancellation of the jet grouted upstream slope stabilization and cutoff wall. Downstream slope stabilization was to be accomplished by jet grouting or soil mixing, but ultimately was accomplished using a self-hardening cement-bentonite (C-B) slurry to construct transverse shear walls. A total of 351 transverse shear walls were constructed along the downstream toe by primarily clamshell equipment. Typical shear walls are 13.7 m long, 1.2 m wide, and extend 18.9 m deep or about 6.1 m into the coarse foundation sands. The walls are spaced at 4.3 m on center along the downstream toe for a replacement ratio of about 29%. In addition to the transverse shear walls, the relief well collection ditch along the downstream toe was replaced with a buried collector system to further improve downstream stability and underseepage control. (C) 2013 American Society of Civil Engineers. C1 [Walberg, Francke C.] URS Corp, Overland Pk, KS 66210 USA. [Stark, Timothy D.] Univ Illinois, Urbana, IL 61801 USA. [Nicholson, Peter J.] Nicholson Consulting LLC, Boca Raton, FL 33428 USA. [Castro, Gonzalo] GEI Consultants Inc, Geotech Engineers Inc, Woburn, MA 01801 USA. [Byrne, Peter M.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Axtell, Paul J.] Dan Brown & Associates, Overland Pk, KS 66212 USA. [Dillon, John C.] USA, Cost Estimating Sect, Corps Engineers, Kansas City, MO 64106 USA. [Empson, William B.] USA, Risk Management Ctr West Denver, Inst Water Resources, Corps Engineers, Lakewood, CO 80288 USA. [Topi, Joseph E.; Bellew, Glen M.] USA, Geotech Design & Dam Safety Sect, Corps Engineers, Kansas City, MO 64106 USA. [Mathews, David L.] USA, Div Engn, Corps Engineers, Kansas City, MO 64106 USA. RP Stark, TD (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA. EM Francke_Walberg@URSCorp.com; tstark@illinois.edu NR 24 TC 2 Z9 2 U1 0 U2 19 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD JUN PY 2013 VL 139 IS 6 BP 975 EP 986 DI 10.1061/(ASCE)GT.1943-5606.0000818 PG 12 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 143PI UT WOS:000318879300014 ER PT J AU Grujicic, M Arakere, A Ramaswami, S Snipes, JS Yavari, R Yen, CF Cheeseman, BA Montgomery, JS AF Grujicic, M. Arakere, A. Ramaswami, S. Snipes, J. S. Yavari, R. Yen, C-F. Cheeseman, B. A. Montgomery, J. S. TI Gas Metal Arc Welding Process Modeling and Prediction of Weld Microstructure in MIL A46100 Armor-Grade Martensitic Steel SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE gas metal arc welding (GMAW); microstructure evolution; MIL A46100; process modeling ID KINETICS; TRANSFORMATION; REAUSTENITIZATION; THERMODYNAMICS; EVOLUTION; AA5083 AB A conventional gas metal arc welding (GMAW) butt-joining process has been modeled using a two-way fully coupled, transient, thermal-mechanical finite-element procedure. To achieve two-way thermal-mechanical coupling, the work of plastic deformation resulting from potentially high thermal stresses is allowed to be dissipated in the form of heat, and the mechanical material model of the workpiece and the weld is made temperature dependent. Heat losses from the deposited filler-metal are accounted for by considering conduction to the adjoining workpieces as well as natural convection and radiation to the surroundings. The newly constructed GMAW process model is then applied, in conjunction with the basic material physical-metallurgy, to a prototypical high-hardness armor martensitic steel (MIL A46100). The main outcome of this procedure is the prediction of the spatial distribution of various crystalline phases within the weld and the heat-affected zone regions, as a function of the GMAW process parameters. The newly developed GMAW process model is validated by comparing its predictions with available open-literature experimental and computational data. C1 [Grujicic, M.; Arakere, A.; Ramaswami, S.; Snipes, J. S.; Yavari, R.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C-F.; Cheeseman, B. A.; Montgomery, J. S.] USA, Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; US Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this article is based on the study supported by two Army Research Office sponsored grants (W911NF-11-1-0207 and W911NF-09-1-0513) and two US Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). The authors are indebted to Dr. Larry C. Russell, Jr. of ARO for his continuing support and interest in this study. NR 39 TC 13 Z9 13 U1 0 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUN PY 2013 VL 22 IS 6 BP 1541 EP 1557 DI 10.1007/s11665-012-0445-3 PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA 143XR UT WOS:000318903000003 ER PT J AU Sun, WB Liu, ZY Lin, B Huang, JP Videen, G AF Sun, Wenbo Liu, Zhaoyan Lin, Bing Huang, Jianping Videen, Gorden TI The 2nd International Symposium on Atmospheric Light Scattering and Remote Sensing (ISALSaRS'11) SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material C1 [Lin, Bing] NASA, Langley Res Ctr, Washington, DC 20546 USA. [Huang, Jianping] Lanzhou Univ, Lanzhou 730000, Peoples R China. [Videen, Gorden] USA, Res Lab, Washington, DC 20546 USA. EM wenbo.sun-1@nasa.gov NR 0 TC 1 Z9 1 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUN PY 2013 VL 122 SI SI BP 1 EP 2 DI 10.1016/j.jqsrt.2012.12.005 PG 2 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 142VN UT WOS:000318825800001 ER PT J AU Sun, WB Liu, ZY Videen, G Fu, Q Muinonen, K Winker, DM Lukashin, C Jin, ZH Lin, B Huang, JP AF Sun, Wenbo Liu, Zhaoyan Videen, Gorden Fu, Qiang Muinonen, Karri Winker, David M. Lukashin, Constantine Jin, Zhonghai Lin, Bing Huang, Jianping TI For the depolarization of linearly polarized light by smoke particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Linearly polarized light; Depolarization ratio; Particle characterization; Smoke aerosol ID ABSORBING BOUNDARY-CONDITION; TIME-DOMAIN SOLUTION; SCATTERING; SOOT; ABSORPTION AB The CALIPSO satellite mission consistently measures volume (including molecule and particulate) light depolarization ratio of similar to 2% for smoke, compared to similar to 1% for marine aerosols and similar to 15% for dust. The observed similar to 2% smoke depolarization ratio comes primarily from the nonspherical habits of particles in the smoke at certain particle sizes. In this study, the depolarization of linearly polarized light by small sphere aggregates and irregular Gaussian-shaped particles is studied, to reveal the physics between the depolarization of linearly polarized light and smoke aerosol shape and size. It is found that the depolarization ratio curves of Gaussian-deformed spheres are very similar to sphere aggregates in terms of scattering-angle dependence and particle size parameters when particle size parameter is smaller than 1.0 pi. This demonstrates that small randomly oriented nonspherical particles have some common depolarization properties as functions of scattering angle and size parameter. This may be very useful information for characterization and active remote sensing of smoke particles using polarized light. We also show that the depolarization ratio from the CALIPSO measurements could be used to derive smoke aerosol particle size. From the calculation results for light depolarization ratio by Gaussian-shaped smoke particles and the CALIPSO-measured light depolarization ratio of similar to 2% for smoke, the mean particle size of South-African smoke is estimated to be about half of the 532 nm wavelength of the CALIPSO lidar. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Sun, Wenbo; Liu, Zhaoyan; Jin, Zhonghai] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. [Fu, Qiang] Univ Washington, Seattle, WA 98195 USA. [Muinonen, Karri] Univ Helsinki, FIN-00014 Helsinki, Finland. [Sun, Wenbo; Winker, David M.; Lukashin, Constantine; Lin, Bing] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Huang, Jianping] Lanzhou Univ, Lanzhou 730000, Peoples R China. RP Sun, WB (reprint author), NASA, Langley Res Ctr, Mail Stop 420, Hampton, VA 23681 USA. EM wenbo.sun-1@nasa.gov RI Liu, Zhaoyan/B-1783-2010; Richards, Amber/K-8203-2015 OI Liu, Zhaoyan/0000-0003-4996-5738; FU NASA [09-GLORY09-0027]; NASA CLARREO mission FX This work was supported by NASA Glory fund 09-GLORY09-0027 and partially by NASA CLARREO mission. The authors thank Michael I. Mishchenko, Hal B. Maring, Bruce A. Wielicki, and Dave F. Young for their support on this work. NR 23 TC 11 Z9 12 U1 2 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUN PY 2013 VL 122 SI SI BP 233 EP 237 DI 10.1016/j.jqsrt.2012.03.031 PG 5 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 142VN UT WOS:000318825800023 ER PT J AU von Elten, K Sawyer, T Lentz-Kapua, S Kanis, A Studer, M AF von Elten, Kelley Sawyer, Taylor Lentz-Kapua, Sarah Kanis, Adam Studer, Matthew TI A Case of Wolf-Hirschhorn Syndrome and Hypoplastic Left Heart Syndrome SO PEDIATRIC CARDIOLOGY LA English DT Article DE Hypoplastic left heart; Chromosome 4 ID FEATURES AB Wolf-Hirschhorn Syndrome (WHS) is a genetic syndrome that includes a typical facial appearance, mental retardation, growth delay, seizures, and congenital cardiac defects. A deletion of the terminal band of the short arm of chromosome 4, with a breakpoint at the 4p15 to 4p16 region, is the most common genetic mutation causing WHS. Congenital heart disease associated with WHS typically includes atrial and ventricular septal defects, though there are a few case reports of associated complex congenital heart disease. Here we report a case of an infant with a large 4p deletion, with a breakpoint at the 4p12 region, and hypoplasic left heart syndrome. We discuss a possible link between the size of the chromosomal deletion in WHS and the severity of the cardiac defect. C1 [von Elten, Kelley; Sawyer, Taylor; Lentz-Kapua, Sarah; Kanis, Adam; Studer, Matthew] Tripler Army Med Ctr, Dept Pediat, MCHK PE, Honolulu, HI 96859 USA. RP von Elten, K (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Kelley.vonelten@gmail.com NR 7 TC 1 Z9 1 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0172-0643 J9 PEDIATR CARDIOL JI Pediatr. Cardiol. PD JUN PY 2013 VL 34 IS 5 BP 1244 EP 1246 DI 10.1007/s00246-012-0367-8 PG 3 WC Cardiac & Cardiovascular Systems; Pediatrics SC Cardiovascular System & Cardiology; Pediatrics GA 143MH UT WOS:000318871100025 PM 22639003 ER PT J AU Barsoumian, A Calvano, T Markelz, AE Cassidy, R Murray, CK Beckius, ML Mende, K Akers, KS AF Barsoumian, Alice Calvano, Tatjana Markelz, Ana E. Cassidy, Ryan Murray, Clinton K. Beckius, Miriam L. Mende, Katrin Akers, Kevin S. TI Variations of CHROMagar Acinetobacter to detect imipenem-resistant Acinetobacter baumannii-calcoaceticus complex SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Acinetobacter baumannii-calcoaceticus complex; MDR; CHROMagar; carbapenem ID LACTAMASE-PRODUCING ENTEROBACTERIACEAE; SUSCEPTIBILITY TESTING ERRORS; CRITICALLY-ILL PATIENTS; STAPHYLOCOCCUS-AUREUS; SELECTIVE MEDIUM; MRSA II; SPECIMENS; EPIDEMIOLOGY; INFECTION; AGAR AB Background: Acinetobacter baumannii-calcoaceticus complex (ABC) isolates are often multidrug-resistant, including to carbapenems. Chromogenic media can facilitate the rapid detection of Gram-negative bacteria, often with the addition of supplements to a base chromogenic medium to detect resistance. We examined various combinations of available media to detect imipenem resistance among 107 ABC clinical isolates. Methods: CHROMagar Orientation, CHROMagar KPC, and CHROMagar Acinetobacter, by itself, with Acinetobacter supplement, with KPC supplement, or CHROMagar Acinetobacter with increasing concentrations (1, 2.5, and 5 ml/l) of a new CR102 supplement, were examined. Results: Sensitivity for the detection of isolates was high (> 98%) for all formulations. Specificity was high for CHROMagar Acinetobacter with 2.5 ml/l and 5 ml/l of the CR102 supplement, at 95.3% and 97.7%, respectively, with positive predictive values of 97% and 98.5%. Negative predictive values of these 2 formulations were 100%. Conclusions: CHROMagar Acinetobacter with the addition of the CR102 supplement at 2.5 ml/l and 5ml/l is highly sensitive and specific for the detection of imipenem-resistant ABC, and may be useful for the rapid detection of imipenem-resistant ABC in clinical samples. C1 [Barsoumian, Alice; Calvano, Tatjana; Markelz, Ana E.; Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Cassidy, Ryan] Univ Texas Austin, Austin, TX 78712 USA. [Murray, Clinton K.; Akers, Kevin S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Beckius, Miriam L.] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Akers, KS (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, MCHE MDI, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kevin.akers@us.army.mil RI Valle, Ruben/A-7512-2013; OI Cassidy, Ryan/0000-0003-4100-0413 FU US Armed Forces Health Surveillance Center; Division of Global and Emerging Infections Surveillance and Response System Operations; Infectious Diseases Clinical Research Program FX The authors gratefully acknowledge the support of the US Armed Forces Health Surveillance Center, Division of Global and Emerging Infections Surveillance and Response System Operations, and the Infectious Diseases Clinical Research Program. NR 28 TC 4 Z9 4 U1 1 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PD JUN PY 2013 VL 45 IS 6 BP 446 EP 452 DI 10.3109/00365548.2013.759270 PG 7 WC Infectious Diseases SC Infectious Diseases GA 144LI UT WOS:000318940400005 PM 23317168 ER PT J AU Cunningham, D Everton, S Wilson, G Padilla, C Zimmerman, D AF Cunningham, Dan Everton, Sean Wilson, Greg Padilla, Carlos Zimmerman, Doug TI Brokers and Key Players in the Internationalization of the FARC SO STUDIES IN CONFLICT & TERRORISM LA English DT Article ID COMMUNITY STRUCTURE; NETWORKS; CENTRALITY AB The Fuerzas Armadas Revolucionarias de Colombia (Revolutionary Armed Forces of ColombiaFARC) was originally founded to protect Colombian peasants from harsh landowner policies in exchange for food and supplies. Over time, it has evolved into an internationally connected, narco-trafficking organization that displays little concern for the peasants it once vowed to protect. In recent years, Colombian authorities have become more adept at countering the FARC, forcing it to operate increasingly outside of Colombia. The FARC's transformation from a local insurgency into an internationally connected one is the focus of this article. Using social network analysis it identifies key leaders who are tied to this transformation and discusses implications concerning the FARC's future. C1 [Cunningham, Dan; Everton, Sean; Wilson, Greg] USN, Postgrad Sch, Def Anal Dept, Monterey, CA 93943 USA. [Zimmerman, Doug] USA, Washington, DC USA. RP Everton, S (reprint author), USN, Postgrad Sch, Codirector Core Lab, Def Anal Dept, 589 Dyer Rd,Root Hall 203, Monterey, CA 93943 USA. EM sfeverto@nps.edu NR 60 TC 1 Z9 1 U1 1 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1057-610X EI 1521-0731 J9 STUD CONFL TERROR JI Stud. Confl. Terror. PD JUN 1 PY 2013 VL 36 IS 6 BP 477 EP 502 DI 10.1080/1057610X.2013.784603 PG 26 WC International Relations; Political Science SC International Relations; Government & Law GA 145TM UT WOS:000319040700003 ER PT J AU Povich, TJ Dawson, CN Farthing, MW Kees, CE AF Povich, T. J. Dawson, C. N. Farthing, M. W. Kees, C. E. TI Finite element methods for variable density flow and solute transport SO COMPUTATIONAL GEOSCIENCES LA English DT Article DE Saltwater intrusion; Variable density; Stabilized FEM; Velocity post-processing ID COUPLED GROUNDWATER-FLOW; POROUS-MEDIA; SIMULATION; BENCHMARK; MODELS; CONVECTION; HENRY; BRINE AB Saltwater intrusion into coastal freshwater aquifers is an ongoing problem that will continue to impact coastal freshwater resources as coastal populations increase. To effectively model saltwater intrusion, the impacts of increased salt content on fluid density must be accounted for to properly model saltwater/freshwater transition zones and sharp interfaces. We present a model for variable density fluid flow and solute transport where a conforming finite element method discretization with a locally conservative velocity post-processing method is used for the flow model and the transport equation is discretized using a variational multiscale stabilized conforming finite element method. This formulation provides a consistent velocity and performs well even in advection-dominated problems that can occur in saltwater intrusion modeling. The physical model is presented as well as the formulation of the numerical model and solution methods. The model is tested against several 2-D and 3-D numerical and experimental benchmark problems, and the results are presented to verify the code. C1 [Povich, T. J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Dawson, C. N.] Univ Texas Austin, Computat Hydraul Grp, Austin, TX 78712 USA. [Farthing, M. W.; Kees, C. E.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Povich, TJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM Timothy.Povich@usma.edu FU US DoD User Productivity Enhancement, Technology Transfer, and Training Program [PP-EQM-KY02-0001-P3]; Omar N. Bradley Foundation Fellowship FX This research was funded by the US DoD User Productivity Enhancement, Technology Transfer, and Training Program (contract PP-EQM-KY02-0001-P3, "Saltwater Intrusion and Density Driven Flow Modeling in ADH"). The first author was also partially funded with the support of an Omar N. Bradley Foundation Fellowship. Permission was granted by the Chief of Engineers to publish this information. NR 43 TC 7 Z9 7 U1 0 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1420-0597 J9 COMPUTAT GEOSCI JI Comput. Geosci. PD JUN PY 2013 VL 17 IS 3 SI SI BP 529 EP 549 DI 10.1007/s10596-012-9330-2 PG 21 WC Computer Science, Interdisciplinary Applications; Geosciences, Multidisciplinary SC Computer Science; Geology GA 138IH UT WOS:000318501700008 ER PT J AU Satapathi, S Kokil, A Venkatraman, BH Li, L Venkataraman, D Kumar, J AF Satapathi, Soumitra Kokil, Akshay Venkatraman, B. Harihara Li, Lian Venkataraman, Dhandapani Kumar, Jayant TI Sensitive Detection of Nitroaromatics With Colloidal Conjugated Polymer Nanoparticles SO IEEE SENSORS JOURNAL LA English DT Article DE DNT; fluorescence quenching; nanoparticle; polythiophene; surfactant; TNT ID SOLUBLE POLYTHIOPHENE; FLUORESCENCE; TNT; EXPLOSIVES; SENSORS AB We observe more than two orders of magnitude enhancement of fluorescence quenching in colloidal conjugated polymer nanoparticles by nitroaromatic analytes compared to solution of the same polymer in organic solvents. This observation is surprising as the quantum efficiency of fluorescence of the polymer solution is significantly higher. The colloidal nanoparticle dispersions of substituted polythiophene derivative are fabricated by the surfactant-assisted mini-emulsion technique. Stern-Volmer constants are determined using both one-photon and two-photon excitation methods. We believe strong analyte-nanoparticle interaction results in the large value of the Stern-Volmer constants measured. The nanoparticle-based sensor described here is suitable for developing a field-based sensory device for detecting a broad class of nitroaromatics in solution. C1 [Satapathi, Soumitra; Kokil, Akshay; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Satapathi, Soumitra; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. [Venkatraman, B. Harihara; Venkataraman, Dhandapani] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA. [Li, Lian] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Satapathi, S (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. EM soumitrasatapathi@gmail.com; akshay_kokil@uml.edu; harihvr@gmail.com; lian_li@uml.edu; dv@chem.umass.edu; jayant_kumar@uml.edu RI Venkataraman, Dhandapani/A-8226-2008; Kokil, Akshay/A-6886-2009 OI Venkataraman, Dhandapani/0000-0003-2906-0579; Kokil, Akshay/0000-0002-8295-2878 FU Army Research Lab; National Science Foundation FX This work was supported in part by the Army Research Lab and National Science Foundation. The associate editor coordinating the review of this paper and approving it for publication was Prof. Yu-Cheng Lin. NR 19 TC 6 Z9 6 U1 4 U2 51 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD JUN PY 2013 VL 13 IS 6 BP 2329 EP 2333 DI 10.1109/JSEN.2013.2252237 PG 5 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 141EB UT WOS:000318707300019 ER PT J AU Unnikrishnan, VU Unnikrishnan, GU Reddy, JN Rostam-Abadi, F AF Unnikrishnan, V. U. Unnikrishnan, G. U. Reddy, J. N. Rostam-Abadi, F. TI Multiscale analysis of impact mitigation in soft tissues using nanotube reinforced composites SO INTERNATIONAL JOURNAL OF MECHANICS AND MATERIALS IN DESIGN LA English DT Article DE Nanocomposite; Shrapnel; Impact; Molecular dynamics; Poroelastic ID MOLECULAR-DYNAMICS SIMULATIONS; SHORT-FIBER COMPOSITES; TRABECULAR BONE; ORIENTATION; NANOCOMPOSITES; UNCERTAINTIES; MECHANICS; CONTINUUM; BEHAVIOR; POROSITY AB Kinetic energy of an inert projectile or its fragment can cause considerable damage to soft tissues and cause debilitating injuries or fatalities. The primary aim of threat mitigation due to kinetic energy dissipation is to provide adequate protection against projectiles or fragments in the form of body shields. Recently, novel nanocomposite materials reinforced with nanotubes are used as shields to protect the soft-tissues during impact. Soft tissues constitute an important part of human body performing various mechanical functions and a deep understanding of the behavior of soft tissue is required to characterize its response to external mechanical forces. Soft tissues are non-homogenous anisotropic materials, and their properties are dependent on the the physiological structure. In this paper, a multiscale homogenization-based analysis of the constituent properties of soft tissues and underlying endoskeleton are developed for impact mitigation using nanotube-reinforced composite shields. C1 [Unnikrishnan, V. U.] Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA. [Unnikrishnan, G. U.] Boston Univ, Dept Mech Engn, Boston, MA 02445 USA. [Reddy, J. N.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Rostam-Abadi, F.] USA, Tank Automot & Armaments Command, AMSTA TR R, Warren, MI 48397 USA. RP Unnikrishnan, VU (reprint author), Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA. EM vunnikrishnan@ua.edu RI Reddy, Junuthula/D-7737-2013 OI Reddy, Junuthula/0000-0002-9739-1639 NR 38 TC 1 Z9 1 U1 1 U2 16 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1569-1713 J9 INT J MECH MATER DES JI Int. J. Mech. Mater. Des. PD JUN PY 2013 VL 9 IS 2 SI SI BP 181 EP 189 DI 10.1007/s10999-013-9221-2 PG 9 WC Engineering, Civil; Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 140LT UT WOS:000318656300006 ER PT J AU Hromadka, TV Jaye, M Phillips, M Hromadka, T Phillips, D AF Hromadka, T. V., II Jaye, M. Phillips, M. Hromadka, T., III Phillips, D. TI Mathematical Model of Cryospheric Response to Climate Changes SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article DE Global climate change; Cryosphere; Mathematical model; Phase change; Differential equation model ID VOSTOK ICE-CORE; FREEZING FRONTS; SOIL; HEAT; SEGREGATION; RECORD AB This paper focuses on the development of simplified mathematical models of the cryosphere which may be useful in further understanding possible global climate change impacts and in further assessing future impacts captured by global circulation models (GCMs). The mathematical models developed by leveraging the dominating effects of freezing and thawing within the cryosphere to simplify the relevant heat transport equations are tractable to direct solution or numerical modeling. In this paper, the heat forcing function is assumed to be a linear transformation of temperature (assumed to be represented by proxy realizations). The output from the governing mathematical model is total ice volume of the cryosphere. The basic mathematical model provides information as a systems modeling approach that includes sufficient detail to explain ice volume given the estimation of the heat forcing function. A comparison between modeling results in the estimation of ice volume versus ice volume estimates developed from use of proxy data are shown in the demonstration problems presented. C1 [Hromadka, T. V., II; Phillips, M.; Phillips, D.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Jaye, M.] USN, Dept Def Anal, Postgrad Sch, Monterey, CA 93943 USA. [Hromadka, T., III] Univ Calif San Diego, Dept Comp Sci, La Jolla, CA 92093 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM ted@phdphdphd.com FU United States Military Academy, West Point, New York, Department of Mathematical Sciences; Naval Post Graduate School, Monterey, California, Department of Defense Analysis FX Acknowledgements are paid to the United States Military Academy, West Point, New York, Department of Mathematical Sciences and the Naval Post Graduate School, Monterey, California, Department of Defense Analysis for their support to the authors during this research. Also acknowledged are the several individuals who have participated in particular tasks in developing this paper including, but by no means limited to, Rene Perez, Laura Hromadka, Bethany Espinosa, and Michael Barton. NR 44 TC 1 Z9 1 U1 2 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD JUN PY 2013 VL 27 IS 2 BP 67 EP 93 DI 10.1061/(ASCE)CR.1943-5495.0000053 PG 27 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 139GE UT WOS:000318569200002 ER PT J AU Finn, S AF Finn, Stephen TI Using Psychology Experiments in Introductory Philosophy Courses SO TEACHING PHILOSOPHY LA English DT Article AB In this paper, I describe a variety of psychology experiments that may be used in introductory philosophy courses not only to grab students' attention, but also to generate philosophical discussion or to make a philosophical point. The experiments attempt to capture students' interest in two ways: (1) by posing interesting challenges to students, thereby provoking more active thought in class and (2) by doing something different, thereby increasing attention that naturally follows from change. Although the experiments are psychology experiments, they may still be used to emphasize certain philosophical points or to introduce philosophical topics. The philosophical import of each experiment is quite general, so these exercises are most appropriate for students enrolled in introductory courses. C1 [Finn, Stephen] US Mil Acad, West Point, NY 10996 USA. [Finn, Stephen] US Mil Acad, Ctr Fac Excellence, West Point, NY USA. RP Finn, S (reprint author), US Mil Acad, West Point, NY 10996 USA. EM stephen.finn@usma.edu NR 9 TC 0 Z9 0 U1 0 U2 2 PU PHILOSOPHY DOCUMENTATION CENTER PI CHARLOTTESVILLE PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA SN 0145-5788 J9 TEACH PHILOS JI Teach Philos. PD JUN PY 2013 VL 36 IS 2 BP 125 EP 135 DI 10.5840/teachphil201336217 PG 11 WC Philosophy SC Philosophy GA 141UP UT WOS:000318752300002 ER PT J AU Bandera, BC Strode, M Rice, R AF Bandera, Bradley C. Strode, Matthew Rice, Robert TI Nonoperative Management of Complicated Diverticulitis with Extradigestive Air SO AMERICAN SURGEON LA English DT Article C1 [Bandera, Bradley C.; Strode, Matthew; Rice, Robert] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA USA. RP Bandera, BC (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Augusta, GA 30905 USA. EM b.bandera07@comcast.net NR 2 TC 1 Z9 1 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD JUN PY 2013 VL 79 IS 6 BP E243 EP E245 PG 3 WC Surgery SC Surgery GA AI6DY UT WOS:000336962000012 PM 23711261 ER PT J AU Bioucas-Dias, JM Plaza, A Camps-Valls, G Scheunders, P Nasrabadi, NM Chanussot, J AF Bioucas-Dias, Jose M. Plaza, Antonio Camps-Valls, Gustavo Scheunders, Paul Nasrabadi, Nasser M. Chanussot, Jocelyn TI Hyperspectral Remote Sensing Data Analysis and Future Challenges SO IEEE GEOSCIENCE AND REMOTE SENSING MAGAZINE LA English DT Article AB Hyperspectral remote sensing technology has advanced significantly in the past two decades. Current sensors onboard airborne and spaceborne platforms cover large areas of the Earth surface with unprecedented spectral, spatial, and temporal resolutions. These characteristics enable a myriad of applications requiring fine identification of materials or estimation of physical parameters. Very often, these applications rely on sophisticated and complex data analysis methods. The sources of difficulties are, namely, the high dimensionality and size of the hyperspectral data, the spectral mixing (linear and nonlinear), and the degradation mechanisms associated to the measurement process such as noise and atmospheric effects. This paper presents a tutorial/overview cross section of some relevant hyperspectral data analysis methods and algorithms, organized in six main topics: data fusion, unmixing, classification, target detection, physical parameter retrieval, and fast computing. In all topics, we describe the state-of-the-art, provide illustrative examples, and point to future challenges and research directions. C1 [Bioucas-Dias, Jose M.] Inst Super Tecn, Inst Telecomunicacoes, P-10491 Lisbon, Portugal. [Plaza, Antonio] Univ Extremadura, Escuela Politecn Caceres, Dept Technol Comp & Commun, Hyperspectral Comp Lab, Caceres 10003, Spain. [Camps-Valls, Gustavo] Univ Valencia, Image Proc Lab, E-46980 Paterna, Valencia, Spain. [Scheunders, Paul] Univ Antwerp, Vis Lab, Dept Phys, iMinds, B-2610 Antwerp, Belgium. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. [Chanussot, Jocelyn] Grenoble Inst Technol, GIPSA Lab, Grenoble, France. RP Bioucas-Dias, JM (reprint author), Inst Super Tecn, Inst Telecomunicacoes, P-10491 Lisbon, Portugal. EM bioucas@lx.it.pt; aplaza@unex.es; gustavo.camps@uv.es; paul.scheunders@ua.ac.be; nasser.m.nasrabadi.civ@mail.mil; jocelyn.chanussot@gipsa-lab.grenoble-inp.fr RI Bioucas-Dias, Jose/C-5479-2009 NR 187 TC 60 Z9 74 U1 7 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-6831 J9 IEEE GEOSC REM SEN M JI IEEE Geosci. Remote Sens. Mag. PD JUN PY 2013 VL 1 IS 2 BP 6 EP 36 DI 10.1109/MGRS.2013.2244672 PG 31 WC Geochemistry & Geophysics; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Remote Sensing; Imaging Science & Photographic Technology GA V45AS UT WOS:000209790100003 ER PT J AU Curtis, TM Howard, A Gerlach, BD Brennan, LM Widder, MW van der Schalie, WH Vo, NTK Bols, NC AF Curtis, T. M. Howard, A. Gerlach, B. D. Brennan, L. M. Widder, M. W. van der Schalie, W. H. Vo, N. T. K. Bols, N. C. TI Suitability of Invertebrate and Vertebrate Cells in a Portable Impedance-based Toxicity Sensor: Temperature Mediated Impacts on Long-term Survival SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Curtis, T. M.; Howard, A.; Gerlach, B. D.] SUNY Coll Cortland, Dept Biol Sci, Cortland, NY 13045 USA. [Brennan, L. M.; Widder, M. W.; van der Schalie, W. H.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Vo, N. T. K.; Bols, N. C.] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada. EM Theresa.curtis@cortland.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 EI 1543-706X J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUN PY 2013 VL 49 SU 1 MA A-2002 BP S41 EP S41 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA V41LL UT WOS:000209547600103 ER PT J AU Shah, NR Bieniarz, MC Basra, SS Paisley, RD Loyalka, P Gregoric, ID Mann, DL Kar, B AF Shah, Nishant R. Bieniarz, Mark C. Basra, Sukhdeep S. Paisley, Robert D. Loyalka, Pranav Gregoric, Igor D. Mann, Douglas L. Kar, Biswajit TI Serum Biomarkers in Severe Refractory Cardiogenic Shock SO JACC-HEART FAILURE LA English DT Article DE biomarkers; cardiogenic shock; heart failure; percutaneous left ventricular assist device AB Objectives The aim of this study was to characterize levels of serum biomarkers in patients with severe refractory cardiogenic shock (SRCS) and to document temporal changes in these levels during restoration of circulation. Background Patients with SRCS have been challenging to study because of their rapidly changing clinical condition while undergoing multiple simultaneous interventions. Methods Twenty-one patients with SRCS received circulatory support via a percutaneously implanted ventricular assist device (PVAD). Serum samples obtained prior to PVAD support initiation, at 24 h of PVAD support, and at 7 days of PVAD support were assayed for B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hsCRP), soluble tumor necrosis factor receptor-1 (sTNFR1), soluble Fas (sFas), soluble Fas ligand (sFasL), endothelin-1, and procollagen III N-terminal peptide (PIIINP). Baseline biomarker levels were qualitatively compared to reference values; levels at 24 h of PVAD support and at 7 days of PVAD support were compared to baseline using 2-tailed Wilcoxon matched pair signed rank tests with Bonferroni correction for multiple comparisons. Results These patients with SRCS had elevated serum levels of BNP, hsCRP, sTNFR1, endothelin-1, and PIIINP. Ventricular unloading and restoration of circulation via PVAD support in patients with SRCS were associated with reductions in serum BNP, sFas, and endothelin-1 levels and increases in serum sFasL and PIIINP levels. Conclusions This study characterizes several important baseline serum biomarker levels in patients with SRCS and introduces a novel PVAD-based protocol with the potential to "reverse"-model the pathophysiology of cardiogenic shock. (c) 2013 by the American College of Cardiology Foundation C1 [Shah, Nishant R.] Baylor Coll Med, Texas Heart Inst, Houston, TX 77030 USA. [Bieniarz, Mark C.] New Mexico Heart Inst, Albuquerque, NM USA. [Basra, Sukhdeep S.] Baylor Coll Med, Houston, TX 77030 USA. [Paisley, Robert D.] US Army, Joint Base Elmendorf Richardson, Infantry Airborne 3 509, Richardson, AK USA. [Loyalka, Pranav; Gregoric, Igor D.; Kar, Biswajit] Univ Texas Hlth Sci Ctr Houston, Texas Heart Inst, Houston, TX 77030 USA. [Mann, Douglas L.] Washington Univ, Sch Med, St Louis, MO USA. RP Kar, B (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Adv Heart Failure, 6410 Fannin St,Suite 920, Houston, TX 77030 USA. EM biswajit.kar@uth.tmc.edu OI Mann, Douglas /0000-0002-2516-0145 NR 22 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-1779 EI 2213-1787 J9 JACC-HEART FAIL JI JACC-Heart Fail. PD JUN PY 2013 VL 1 IS 3 BP 200 EP 206 DI 10.1016/j.jchf.2013.03.002 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA V41GU UT WOS:000209535500003 PM 24621870 ER PT J AU Sutorik, AC Cooper, C Green, MD Wolfenstine, J Gilde, G AF Sutorik, A. C. Cooper, C. Green, M. D. Wolfenstine, J. Gilde, G. TI The Effect of Different La-Containing Starting Materials on the Synthesis, Sintering, and Li+-Conductivity of Li3xLa2/3-xTiO3 SO JOURNAL OF CERAMIC SCIENCE AND TECHNOLOGY LA English DT Article DE Li+-conducting ceramic; Li-air battery; ceramic electrolyte; lithium lanthanum titanate AB Li3xLa2/3-xTiO3 is a promising ceramic electrolyte for high energy density Li-batteries. The material is usually prepared from solid state reactions between Li2CO3, La2O3, and TiO2, but the hydroscopic nature of La2O3 leads to inconsistencies in formulation and synthetic outcome which can impact the phase formation and corresponding Li-conductivity of the final ceramic. To address this issue, La carbonate and hydroxides have been evaluated as starting materials for solid state synthesis of Li3xLa2/3-xTiO3 powders and sintered ceramic. The different La-starting materials are all prepared from precipitation reaction as high surface area powders. These are characterized for phase, particle size, particle morphology, and ceramic yield (by thermal gravimetric analysis). The La starting materials are then mixed with the desired stoichiometric amounts of Li2CO3 and TiO2. The mixtures are calcined at 1100 degrees C for 1 h before being pressed into green parts and sintered at either 1200 or 1300 degrees C for 6 h. Under nearly all conditions investigated, the formulations using the La-carbonate-based starting material lead to ceramics with the highest bulk density, the highest degree of cubic superstructure formation, and the highest lattice Lit-conductivity. Total conductivity, however, appears largely insensitive to the La starting material used. C1 [Sutorik, A. C.; Cooper, C.; Green, M. D.; Gilde, G.] US Army, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. [Wolfenstine, J.] US Army, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Sutorik, AC (reprint author), US Army, Res Lab, RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM anthony.sutorik1@us.army.mil NR 27 TC 3 Z9 3 U1 4 U2 13 PU GOLLER VERLAG GMBH PI BADEN BADEN PA ASCHMATTSTRASSE 8, D-76532 BADEN BADEN, GERMANY SN 2190-9385 J9 J CERAM SCI TECHNOL JI J. Ceram. Sci. Technol. PD JUN PY 2013 VL 4 IS 2 SI SI BP 59 EP 68 DI 10.4416/JCST2012-00035 PG 10 WC Materials Science, Ceramics SC Materials Science GA V36FY UT WOS:000209199600002 ER PT J AU Honey, JR AF Honey, James R. TI The Army Selected Reserve Dental Readiness System: Overview, Assessment, and Recommendations SO MILITARY MEDICINE LA English DT Article AB The Army Selected Reserve Dental Readiness System (ASDRS) is a key dental program directed by the Assistant Secretary of the Army (Manpower & Reserve Affairs) starting in fiscal year 09. The Army National Guard and Army Reserve have steadily implemented ASDRS over the past 3 years as a means to improve the historically abysmal dental readiness of the Army Reserve Component (RC). Dental readiness is essential for sustaining an Army RC Operational Force. ASDRS is a tool for RC commanders to provide contract dental readiness care in support of over 558 thousand nonmobilized Selected Reserve Citizen-Soldiers dispersed throughout the 54 states and U.S. territories, at home station before alert, and if necessary after alert (throughout the Army force generation cycle). This article examines the status of ASDRS implementation, assesses its effectiveness in improving Army RC Dental Readiness, and provides Army leadership recommendations regarding the following focus areas: (1) command emphasis, (2) program execution, and (3) synergy with the Military Health System and Department of Veterans Affairs. C1 US Army Reserve Command, Army Reserve Surg Off, Ft Bragg, NC 28310 USA. RP Honey, JR (reprint author), US Army Reserve Command, Army Reserve Surg Off, 4710 Knox St Bldg 8-1808, Ft Bragg, NC 28310 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2013 VL 178 IS 6 BP 607 EP 618 DI 10.7205/MILMED-D-12-00445 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TZ UT WOS:000340805200004 PM 23756066 ER PT J AU Gubata, ME Oetting, AA Niebuhr, DW Cowan, DN AF Gubata, Marlene E. Oetting, Alexis A. Niebuhr, David W. Cowan, David N. TI Accession Medical Waivers and Deployment Duration in the US Army SO MILITARY MEDICINE LA English DT Article ID MILITARY ENLISTEES; SURVIVAL ANALYSIS; RISK-FACTORS; ATTRITION; DISCHARGE; RECRUITS; SERVICE; HOSPITALIZATION; STANDARDS; INJURY AB To examine the performance of active duty U.S. Army personnel with accession medical waivers during combat deployments, the deployment duration and likelihood of early return from theater for medically waived (n = 18,093) and medically qualified (77 = 250,209) personnel deploying between September 2001 and March 2011 were determined. The mean and median deployment duration for waived men (309.4 +/- 107.5 and 346) and for waived women (291.8 +/- 115.3 and 341) was not shorter than for medically qualified men (304.6 +/- 112.1 and 346) and women (289.5 +/- 116.3 and 337). When adjusted for other accession factors in a multivariate linear regression model, neither waived men (p = 1.00) nor women (p = 0.7713) had significantly shorter deployments. In a case-control analysis, 24,369 men and 3,094 women were defined as having a short deployment. Multivariate logistic regression found that medically waived men (odds ratio [OR] = 0.87, 95% confidence interval [CI] = 0.82-0.92) and women (OR = 1.02, 95% CI = 0.87-1.19) were not more likely to have shorter deployments compared to medically qualified individuals. These findings show that those with an accession medical waiver were not more likely to have shorter deployments or more likely to return early from deployment than those without waivers. C1 [Gubata, Marlene E.; Oetting, Alexis A.; Niebuhr, David W.; Cowan, David N.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, Silver Spring, MD 20910 USA. [Oetting, Alexis A.; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. FU Defense Health Program FX This work was funded by the Defense Health Program. NR 27 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2013 VL 178 IS 6 BP 625 EP 630 DI 10.7205/MILMED-D-13-00010 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TZ UT WOS:000340805200006 PM 23756068 ER PT J AU Hill, OT Bulathsinhala, L Scofield, DE Haley, TF Bernasek, TL AF Hill, Owen T. Bulathsinhala, Lakmini Scofield, Dennis E. Haley, Timothy F. Bernasek, Thomas L. TI Risk Factors for Soft Tissue Knee Injuries in Active Duty US Army Soldiers, 2000-2005 SO MILITARY MEDICINE LA English DT Article ID ANTERIOR CRUCIATE LIGAMENT; OPERATION IRAQI FREEDOM; PHYSICAL-ACTIVITIES; OSTEOARTHRITIS; DISABILITY; DISORDERS; RECONSTRUCTION; HISTORY; REPAIR; JOINT AB Background: There is a scarcity of analytic research on active duty Army (ADA) knee injuries (KI), such as soft tissue knee injuries (STKI), which are the predominant ADA KI pattern. Purpose: To quantify the independent adjusted association of significant ADA STKI risk factors, 2000-2005. Materials/Methods: Using the Total Army Injury and Health Outcomes Database, we (1) captured absolute STKI numbers and rates (N = 83,323) and (2) developed regression models to determine significant STKI risk factors. Models included STKI overall and subcategories: meniscus, patella, anterior/posterior cruciate ligament, and medial/lateral cruciate ligament. Results: Eight risk factors significantly increased STKI. They are: (1) prior KI (within 2 years) (odds ratio [OR] 9.83, 95% confidence interval [CI] 9.67-10.00); (2) increasing length of service (OR 1.83, 95% CI 1.76-1.90); (3) increasing age (OR 1.57, 95% CI 1.50-1.65); (4) prior deployment (OR 1.39, 95% CI 1.36-1.41); (5) prior ankle injury (OR 1.16, 95% CI 1.14-1.19); (6) Infantry occupation (OR 1.12, 95% CI 1.04-1.21); (7) marital status (OR 1.10, 95% CI 1.08-1.12); (8) and prior hip injury (OR 1.08, 95% CI 1.03-1.12). Major Conclusion: Soldiers with a prior KI have nearly a 10-fold increased relative risk of developing a subsequent STKI. C1 [Hill, Owen T.; Bulathsinhala, Lakmini; Scofield, Dennis E.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Haley, Timothy F.] US Army Res Inst Environm Med, Off Med Support & Oversight, Natick, MA 01760 USA. [Bernasek, Thomas L.] Florida Orthopaed Inst, Tampa, FL 33637 USA. RP Hill, OT (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. RI SCOFIELD, DENNIS/F-3636-2015 FU Military Operational Medicine Research Program [8840]; U.S. Army Research Institute of Environmental Medicine FX This study was made possible by internal funding from the Military Operational Medicine Research Program, Proposal No. 8840. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command. NR 34 TC 8 Z9 8 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2013 VL 178 IS 6 BP 676 EP 682 DI 10.7205/MILMED-D-13-00049 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TZ UT WOS:000340805200014 PM 23756076 ER PT J AU Hall, NM Jones, FJ Ainsworth, CR Fincher, RK AF Hall, Noah M. Jones, Frances J. Ainsworth, Craig R. Fincher, R. Keith TI Methemoglobinemia in Patients Undergoing Esophagogastroduodenoscopy: A Randomized Controlled Trial SO MILITARY MEDICINE LA English DT Article ID BENZOCAINE-INDUCED METHEMOGLOBINEMIA; OXIMETRY AB Background: Methemoglobinemia is a potentially life-threatening complication of local anesthetic sprays employed in upper endoscopy. There is limited information available on the incidence of this complication, and no prospective trial has ever undertaken to evaluate subclinical levels of methemoglobinemia. Objective: To evaluate the incidence of subclinical methemoglobinemia in patients exposed to anesthetic spray. Methods: Subjects were randomized to a "spray" or "no-spray" group. Subjects in the "spray" group received a 1-second benzocaine spray before upper endoscopy. All subjects in both groups were monitored with a noninvasive co-oximetry device capable of detecting methemoglobin levels in real time. Results: 401 subjects were enrolled (209 in the study group, 192 in the control group); mean peak methemoglobin concentrations were 0.82% (CI 0.74-0.90%, SD 0.57%) and 0.80% (CI 0.73-0.86%, SD 0.46%) respectively. There was no statistically significant difference between the two groups (p = 0.69). Only 3 (1.4%) subjects in the study group and 2 (1%) subjects in the control group had a peak methemoglobin concentration >2%. Conclusions: In this randomized clinical trial, no significant elevation of methemoglobin concentration was observed in any subject. Final analysis failed to demonstrate any statistically significant difference between the two groups. C1 [Hall, Noah M.; Fincher, R. Keith] DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Jones, Frances J.] San Antonio Mil Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. [Ainsworth, Craig R.] Walter Reed Natl Mil Med Ctr, Crit Care Dept, Bethesda, MD 20814 USA. RP Hall, NM (reprint author), DD Eisenhower Army Med Ctr, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. FU Massimo Corporation through the Geneva Foundation FX The funding for this trial in the form of oximetry equipment and academic conference travel expenses was provided by the Massimo Corporation through a grant from the Geneva Foundation. NR 13 TC 2 Z9 2 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2013 VL 178 IS 6 BP 701 EP 704 DI 10.7205/MILMED-D-13-00035 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TZ UT WOS:000340805200018 PM 23756080 ER PT J AU Forney, AJ AF Forney, Andrew J. TI Fighting Jim Crow in the County of Kings: The Congress of Racial Equality in Brooklyn. SO NEW YORK HISTORY LA English DT Book Review C1 [Forney, Andrew J.] US Mil Acad, West Point, NY 10996 USA. RP Forney, AJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK STATE HIST ASSOC PI COOPERSTOWN PA PO BOX 800, COOPERSTOWN, NY 13326-0800 USA SN 0146-437X EI 2328-8132 J9 NEW YORK HIST JI N. Y. Hist. PD SUM-FAL PY 2013 VL 94 IS 3-4 BP 360 EP 362 PG 3 WC History SC History GA V36QF UT WOS:000209225300022 ER PT J AU Nanduri, B Suvarnapunya, AE Venkatesan, M Edelmann, MJ AF Nanduri, Bindu Suvarnapunya, Akamol E. Venkatesan, Malabi Edelmann, Mariola J. TI Deubiquitinating Enzymes as Promising Drug Targets for Infectious Diseases SO CURRENT PHARMACEUTICAL DESIGN LA English DT Article DE Deubiquitinating enzymes; drug discovery; ubiquitin; infectious diseases; post-translational modifications ID NF-KAPPA-B; UBIQUITIN-SPECIFIC PROTEASE; SMALL-MOLECULE INHIBITOR; I INTERFERON-PRODUCTION; INNATE IMMUNE-RESPONSE; NEGATIVE FEEDBACK LOOP; STIMULATED GENE 15; VIRUS TYPE-1 TAX; PLASMODIUM-FALCIPARUM; NONSTRUCTURAL PROTEIN-2 AB Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known to be modulated during the infection process, either by a pathogen or by a host. Recently there have been attempts to take advantage of this feature and design therapeutic inhibitors of DUBs that can be used to limit the spread of infection. This review is focused on exploring the potential of DUBs in the treatment of infectious diseases. C1 [Nanduri, Bindu; Edelmann, Mariola J.] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Mississippi State, MS 39762 USA. [Nanduri, Bindu; Edelmann, Mariola J.] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA. [Suvarnapunya, Akamol E.; Venkatesan, Malabi] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Edelmann, MJ (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Pace Seed Lab, Mailstop 9758,Rm 120,650 Stone Blvd, Mississippi State, MS 39762 USA. EM mje100@mafes.msstate.edu OI Edelmann, Mariola/0000-0003-0459-7716 FU MTA [013743-001]; MAFES Special Research Initiatives (Edelmann) Control of Food-Borne Pathogens [160000-018100-027100-401120]; National Science Foundation [Mississippi EPSCoR-0903787]; Mississippi INBRE; National Center for Research Resources [5P20RR016476-11]; National Institute of General Medical Sciences from the National Institutes of Health [8 P20 GM103476-11] FX The work with WRAIR has been done using the MTA agreement (Award# 013743-001). This work was partially supported by the MAFES Special Research Initiatives (Edelmann) Control of Food-Borne Pathogens (160000-018100-027100-401120), The National Science Foundation (Mississippi EPSCoR-0903787), and Mississippi INBRE funded by grants from the National Center for Research Resources (5P20RR016476-11), and the National Institute of General Medical Sciences (8 P20 GM103476-11) from the National Institutes of Health. NR 140 TC 9 Z9 10 U1 0 U2 19 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1381-6128 EI 1873-4286 J9 CURR PHARM DESIGN JI Curr. Pharm. Design PD JUN PY 2013 VL 19 IS 18 BP 3234 EP 3247 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 133RD UT WOS:000318156100008 PM 23151130 ER PT J AU Scenna, R DuBois, TG Nieh, S AF Scenna, Richard DuBois, Terry G. Nieh, Sen TI Autothermal reforming of synthetic JP-8 derived from a coal syngas stream SO FUEL LA English DT Article DE Autothermal fuel reforming; Coal liquefaction; JP-8 fuel; Fuel reforming; Synthetic paraffinic kerosene fuel ID CATALYTIC PARTIAL OXIDATION; FISCHER-TROPSCH FUEL; LIQUID FUELS; JET FUEL; CARBON FORMATION; DIESEL-FUEL; HYDROCARBONS; GAS; EMISSIONS; HYDROGEN AB The performance characteristics of a coal based synthetic JP-8 fuel were evaluated on an autothermal reformer experimental test stand. The target application for the reformate was a solid oxide fuel cell power unit. The synthetic JP-8 fuel was derived through the Fischer-Tropsch process, resulting in a predominantly paraffin based fuel. The synthetic JP-8 fuel was reacted in an atmospheric pressure autothermal reformer with noble metal catalysts under conditions of steam-to-carbon ratio of 2.0, fuel equivalency energy flow of 3.33 kW thermal to 6.66 kW thermal, and variable oxygen-to-carbon ratios of 0.8-1.2. For all fuel equivalency flow rates investigated, fuel conversion of greater than 96% were achieved. The synthetic fuel produced high reforming efficiencies of up to 92.2%, with hydrogen concentrations up to 36.5%. The results show that coal derived JP-8 fuels can produce high reforming efficiencies, with high hydrogen concentrations while minimizing carbon formation in an ATR reactor. Published by Elsevier Ltd. C1 [Scenna, Richard; DuBois, Terry G.] USA, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA. [Nieh, Sen] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA. RP DuBois, TG (reprint author), USA, Res Dev & Engn Command, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA. EM terry.g.dubois.civ@mail.mil; nieh@cua.edu FU United States Army Research, Development, and Engineering Command; Communication-Electronics Research, Development and Engineering Center under an In-House Laboratory Independent Research project FX The authors gratefully acknowledge support from the United States Army Research, Development, and Engineering Command, Communication-Electronics Research, Development and Engineering Center under an In-House Laboratory Independent Research project. NR 49 TC 7 Z9 7 U1 1 U2 33 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0016-2361 J9 FUEL JI Fuel PD JUN PY 2013 VL 108 BP 731 EP 739 DI 10.1016/j.fuel.2013.02.022 PG 9 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 125TV UT WOS:000317565100085 ER PT J AU David, NV Gao, XL Zheng, JQ AF David, N. V. Gao, X. -L. Zheng, J. Q. TI Creep of a Twaron (R)/Natural Rubber Composite SO MECHANICS OF ADVANCED MATERIALS AND STRUCTURES LA English DT Article DE ballistic fabrics; creep; compliance; retardation time; viscoelasticity; rheological models; natural rubber; para-aramid fibers ID ARAMID FIBERS; VISCOELASTIC PROPERTIES; STRESS RELAXATION; POLYMER FIBERS; NATURAL-RUBBER; TENSILE CREEP; BEHAVIOR; DEFORMATION; TEMPERATURE; EXTENSION AB The creep behavior of a Twaron CT709 (R) fabric/natural rubber composite under a uniaxial constant stress is studied using three viscoelasticity models with different levels of complexity and a newly developed para-rheological model. The three viscoelasticity models employed are a one-term generalized Maxwell (GM n =1) model (consisting of one Maxwell element and an additional spring in parallel), a two-term generalized Maxwell (GM n =2) model (including two parallel Maxwell elements and an additional spring in parallel), and a four-parameter Burgers model. The values of the parameters involved in each model are extracted from the experimental data obtained in this study. The numerical results show that the initial creep response of the composite is predicted fairly well by the GM n =2 model, while the secondary creep is more accurately described by the GM n =1 model. An implicit solution, together with a retardation time spectrum, obtained using the para-rheological model is found to provide more accurate predictions of the composite creep response than the three viscoelasticity models in both the primary and secondary stages. The long-time response of the composite is also studied using the four models, with the para-rheological model providing the best predictions. C1 [David, N. V.] Univ Teknol MARA, Fac Mech Engn, Shah Alam, Selangor, Malaysia. [Gao, X. -L.] Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA. [Zheng, J. Q.] USA, Program Execut Off SOLDIER, Ft Belvoir, VA USA. RP Gao, XL (reprint author), Univ Texas Dallas, Dept Mech Engn, 800 West Campbell Rd, Richardson, TX 75080 USA. EM Xin-Lin.Gao@utdallas.edu RI N.V., David/B-1987-2010 OI N.V., David/0000-0003-4128-5850 FU U.S. Army-Soldier Equipment Program FX The work reported here is partially funded by the U.S. Army-Soldier Equipment Program. This support is gratefully acknowledged. NR 43 TC 0 Z9 0 U1 1 U2 36 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6494 J9 MECH ADV MATER STRUC JI Mech. Adv. Mater. Struct. PD JUN 1 PY 2013 VL 20 IS 6 BP 464 EP 477 DI 10.1080/15376494.2012.676719 PG 14 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing; Materials Science, Composites SC Materials Science; Mechanics GA 121YU UT WOS:000317282600006 ER PT J AU Kim, CS Sohn, I Nezafati, M Ferguson, JB Schultz, BF Bajestani-Gohari, Z Rohatgi, PK Cho, K AF Kim, Chang-Soo Sohn, Il Nezafati, Marjan Ferguson, J. B. Schultz, Benjamin F. Bajestani-Gohari, Zahra Rohatgi, Pradeep K. Cho, Kyu TI Prediction models for the yield strength of particle-reinforced unimodal pure magnesium (Mg) metal matrix nanocomposites (MMNCs) SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID HALL-PETCH PARAMETERS; GRAIN-SIZE DEPENDENCE; MECHANICAL-PROPERTIES; TENSILE PROPERTIES; SILICON-CARBIDE; ZN ALLOY; DEFORMATION MECHANISMS; SIC PARTICLES; LENGTH-SCALE; ELEMENTAL MG AB Particle-reinforced metal matrix nanocomposites (MMNCs) have been lauded for their potentially superior mechanical properties such as modulus, yield strength, and ultimate tensile strength. Though these materials have been synthesized using several modern solid- or liquid-phase processes, the relationships between material types, contents, processing conditions, and the resultant mechanical properties are not well understood. In this paper, we examine the yield strength of particle-reinforced MMNCs by considering individual strengthening mechanism candidates and yield strength prediction models. We first introduce several strengthening mechanisms that can account for increase in the yield strength in MMNC materials, and address the features of currently available yield strength superposition methods. We then apply these prediction models to the existing dataset of magnesium MMNCs. Through a series of quantitative analyses, it is demonstrated that grain refinement plays a significant role in determining the overall yield strength of most of the MMNCs developed to date. Also, it is found that the incorporation of the coefficient of thermal expansion mismatch and modulus mismatch strengthening mechanisms will considerably overestimate the experimental yield strength. Finally, it is shown that work-hardening during post-processing of MMNCs employed by many researchers is in part responsible for improvement to the yield strength of these materials. C1 [Kim, Chang-Soo; Nezafati, Marjan; Ferguson, J. B.; Schultz, Benjamin F.; Bajestani-Gohari, Zahra; Rohatgi, Pradeep K.] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. [Sohn, Il] Yonsei Univ, Dept Mat Sci & Engn, Seoul 120749, South Korea. [Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu RI Schultz, Benjamin/H-8229-2014; OI Schultz, Benjamin/0000-0002-0235-7674; Nezafati, Marjan/0000-0002-6939-0460 FU Research Growth Initiative (RGI) Award from University of Wisconsin-Milwaukee (UWM); U.S. Army Research Laboratory (US ARL) [W911NF-08-2-0014] FX This work is primarily supported by the Research Growth Initiative (RGI) Award from University of Wisconsin-Milwaukee (UWM). Partial support from the U.S. Army Research Laboratory (US ARL) under Cooperative Agreement No. W911NF-08-2-0014 is also acknowledged. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 71 TC 30 Z9 30 U1 1 U2 43 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUN PY 2013 VL 48 IS 12 BP 4191 EP 4204 DI 10.1007/s10853-013-7232-x PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 116VN UT WOS:000316911300005 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI Liquid electrolyte lithium/sulfur battery: Fundamental chemistry, problems, and solutions SO JOURNAL OF POWER SOURCES LA English DT Review DE Lithium/sulfur battery; Polysulfide; Redox shuttle; Electrolyte; Carbon-sulfur composite; Li anode ID COMPOSITE CATHODE MATERIALS; GLYCOL) DIMETHYL ETHER; HIGH-CAPACITY DENSITY; LI-S BATTERY; SULFUR BATTERIES; ELECTROCHEMICAL PROPERTIES; CARBON NANOTUBES; ENHANCED CYCLABILITY; GRAPHENE OXIDE; ION BATTERIES AB Lithium/sulfur (Li/S) battery has a 3-5 fold higher theoretical energy density than state-of-art lithium-ion batteries, and research has been ongoing for more than three decades. However, the commercialization of Li/S battery still cannot be realized due to many problematic issues, including short cycle life, low cycling efficiency, poor safety and a high self-discharge rate. All these issues are related to the dissolution of lithium polysulfide (PS), the series of sulfur reduction intermediates, in liquid electrolyte and to resulting parasitic reactions with the lithium anode and electrolyte components. On the other hand, the dissolution of PS is essential for the performance of a Li/S cell. Without dissolution of PS, the Li/S cell cannot operate progressively due to the non-conductive nature of elemental sulfur and its reduction products. In this review article, we start with the fundamental chemistry of elemental sulfur in order to discuss the problems and solutions of liquid electrolyte Li/S battery. Published by Elsevier B.V. C1 USA, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 106 TC 417 Z9 431 U1 119 U2 1422 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUN 1 PY 2013 VL 231 BP 153 EP 162 DI 10.1016/j.jpowsour.2012.12.102 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 104ZZ UT WOS:000316036700019 ER PT J AU Kalcioglu, ZI Mrozek, RA Mahmoodian, R VanLandingham, MR Lenhart, JL Van Vliet, KJ AF Kalcioglu, Z. Ilke Mrozek, Randy A. Mahmoodian, Roza VanLandingham, Mark R. Lenhart, Joseph L. Van Vliet, Krystyn J. TI Tunable mechanical behavior of synthetic organogels as biofidelic tissue simulants SO JOURNAL OF BIOMECHANICS LA English DT Article DE Tissue simulants; Rheology; Impact indentation; PDMS; Soft tissues; Energy dissipation ID MODEL POLY(DIMETHYLSILOXANE) NETWORKS; STRAIN-ENERGY DENSITY; PENDANT CHAINS; VISCOELASTIC PROPERTIES; HUMAN TORSO; IMPACT; GELS; MODULUS; ENTANGLEMENT; DISSIPATION AB Solvent-swollen polymer gels can be utilized as mechanical simulants of biological tissues to evaluate protective systems and assess injury mechanisms. However, a key challenge in this application of synthetic materials is mimicking the rate-dependent mechanical response of complex biological tissues. Here, we characterize the mechanical behavior of tissue simulant gel candidates comprising a chemically crosslinked polydimethylsiloxane (PDMS) network loaded with a non-reactive PDMS solvent, and compare this response with that of tissue from murine heart and liver under comparable loading conditions. We first survey the rheological properties of a library of tissue simulant candidates to investigate the effects of solvent loading percentage, reactive functional group stoichiometry, and solvent molecular weight. We then quantify the impact resistance, energy dissipation capacities, and energy dissipation rates via impact indentation for the tissue simulant candidates, as well as for the murine heart and liver. We demonstrate that by tuning these variables the silicone gels can be engineered to match the impact response of biological tissues. These experiments inform the design principles required for synthetic polymer gels that are optimized to predict the response of specific biological tissues to impact loading, providing insight for further tuning of this gel system to match the impact response of other "soft tissues". (C) 2013 Published by Elsevier Ltd. C1 [Kalcioglu, Z. Ilke; Mahmoodian, Roza; Van Vliet, Krystyn J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Mrozek, Randy A.; VanLandingham, Mark R.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lenhart, JL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM joseph.lenhart.civ@mail.mil; krystyn@mit.edu FU U.S. Army through the Institute for Soldier Nanotechnologies [W911NF-07-D-0004]; U.S. Army Research Office FX This research was supported in part by the U.S. Army through the Institute for Soldier Nanotechnologies, under Contract W911NF-07-D-0004 with the U.S. Army Research Office. Certain commercial equipment and materials are identified in this paper in order to specify adequately the experimental procedure. In no case does such identification imply recommendations by the Army Research Laboratory nor does it imply that the material or equipment identified is necessarily the best available for this purpose. NR 43 TC 11 Z9 11 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD MAY 31 PY 2013 VL 46 IS 9 BP 1583 EP 1591 DI 10.1016/j.jbiomech.2013.03.011 PG 9 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 170CQ UT WOS:000320827700015 PM 23623681 ER PT J AU Pinzon-Arango, PA Nagarajan, R Camesano, TA AF Pinzon-Arango, Paola A. Nagarajan, Ramanathan Camesano, Terri A. TI Interactions of Antimicrobial Peptide Chrysophsin-3 with Bacillus anthracis in Sporulated, Germinated, and Vegetative States SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID ATOMIC-FORCE MICROSCOPY; RED-SEA BREAM; SPORE GERMINATION; CEREUS; COAT; DISRUPTION; ENDOSPORES; ELASTICITY; MECHANISM; CELLS AB Bacillus anthracis spores contain on their surface multilayered protein coats that provide barrier properties, mechanical strength, and elasticity that aid in protecting the sporulated state and preventing germination, outgrowth, and transition into the virulent vegetative bacterial state. In this work, the antimicrobial peptide (AMP) chrysophsin-3 was tested against B. anthracis in each of the three distinct metabolic states (sporulated, germinated, and vegetative) for its bacteria-killing activity and its ability to modify the surface nanomechanical properties. Our results provide the first demonstration that chrysophsin-3 killed B. anthracis even in its sporulated state while more killing was observed for germinated and vegetative states. The elasticity of vegetative B. anthracis increased from 12 +/- 6 to 84 +/- 17 MPa after exposure to 0.22 mM chrysophsin-3. An increase in cellular spring constant was also observed for chrysophsin-3-treated vegetative B. anthracis. Atomic force microscopy images suggested that the changes in mechanical properties of vegetative B. anthracis after chrysophsin-3 treatment are due to loss of water content and cellular material from the cell, possibly caused by the disruption of the cell membrane by the AMP. In contrast, sporulated and germinated B. anthracis retained their innate mechanical properties. Our data indicate that chrysophsin-3 can penetrate the spore coat of B. anthracis spores and kill them without causing any significant mechanical changes on the spore surface. These results reveal a yet unrecognized role for chrysophsin-3 in the killing of B. anthracis spores without the need for complete germination or release of spore coats. C1 [Pinzon-Arango, Paola A.; Camesano, Terri A.] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA. [Pinzon-Arango, Paola A.; Nagarajan, Ramanathan] USA, Natick Soldier Res Dev & Engn Ctr, Mol Sci & Engn Team, Natick, MA 01760 USA. RP Camesano, TA (reprint author), WPI Life Sci & Bioengn Ctr Gateway Pk, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA. EM terric@wpi.edu OI Nagarajan, Ramanathan/0000-0003-4758-2231 FU National Science Foundation [CBET 0827229, CBET 0922901]; Defense Threat Reduction Agency [BA07PRO102] FX This work was supported in part by the National Science Foundation (CBET 0827229 and CBET 0922901) and Defense Threat Reduction Agency Project BA07PRO102. NR 30 TC 4 Z9 4 U1 2 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAY 30 PY 2013 VL 117 IS 21 BP 6364 EP 6372 DI 10.1021/jp400489u PG 9 WC Chemistry, Physical SC Chemistry GA 157LE UT WOS:000319896800003 PM 23631815 ER PT J AU Macareo, L Lwin, KM Cheah, PY Yuentrakul, P Miller, RS Nosten, F AF Macareo, Louis Lwin, Khin Maung Cheah, Phaik Yeong Yuentrakul, Prayoon Miller, R. Scott Nosten, Francois TI Triangular test design to evaluate tinidazole in the prevention of Plasmodium vivax relapse SO MALARIA JOURNAL LA English DT Article DE Malaria; Plasmodium vivax; Tinidazole; Relapse; Triangular test; Sequential analysis ID CANCER CLINICAL-TRIALS; HEMOLYTIC-ANEMIA; PRIMAQUINE; MALARIA; THAILAND; CYNOMOLGI AB Background: There are very few drugs that prevent the relapse of Plasmodium vivax malaria in man. Tinidazole is a 5-nitroimidazole approved in the USA for the treatment of indications including amoebiasis and giardiasis. In the non-human primate relapsing Plasmodium cynomolgi/macaque malaria model, tinidazole cured one of six macaques studied with an apparent mild delay to relapse in the other five of 14-28 days compared to 11-12 days in controls. One study has demonstrated activity against P. vivax in man. Presented here are the results of a pilot phase II, randomized, open-label study conducted along the Thai-Myanmar border designed to evaluate the efficacy of tinidazole to prevent relapse of P. vivax when administered with chloroquine. Methods: This study utilized a modified triangular test sequential analysis which allows repeated statistical evaluation during the course of enrolment while maintaining a specified power and type 1 error and minimizing recruitment of subjects. Enrolment was to be halted when a pre-specified success/failure ratio was surpassed. The study was designed to have a 5% type 1 error and 90% power to show whether tinidazole would produce a relapse rate of less than 20% or greater than 45% through Day 63 of weekly follow-up after initiation of treatment and initial parasite clearance with 3 days of an oral weight based dosing of chloroquine and five days of 2 grams/day of tinidazole. Results: All subjects cleared their parasitaemia by Day 3. Six of the first seven subjects treated with tinidazole relapsed prior to Day 63 (average Day 48.3 (range 42-56)). This exceeded the upper boundary of the triangular test and enrolment to receive tinidazole was halted. A concurrent cohort of five subjects definitively treated with standard doses of primaquine and chloroquine (historically 100% effective) showed no episodes of recurrent P. vivax parasitaemia during the 63-day protocol specified follow-up period. Conclusions: Tinidazole is ineffective in preventing relapse of P. vivax at the dose used. The macaque relapsing model appeared to correctly predict outcome in humans. Use of the modified triangular test allowed minimal enrolment and limited unnecessary exposure to the study drug and reduced costs. This adds weight to the ethical and economic advantages of this study design to evaluate similarly situated drugs. C1 [Macareo, Louis; Miller, R. Scott] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Lwin, Khin Maung; Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot 63110, Thailand. [Lwin, Khin Maung; Cheah, Phaik Yeong; Yuentrakul, Prayoon; Nosten, Francois] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand. [Cheah, Phaik Yeong; Nosten, Francois] Univ Oxford, CCVTM, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 7LJ, England. RP Macareo, L (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM louis.macareo@us.army.mil OI Nosten, Francois/0000-0002-7951-0745 FU Wellcome Trust [089275] NR 18 TC 4 Z9 4 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 29 PY 2013 VL 12 AR 173 DI 10.1186/1475-2875-12-173 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 156NU UT WOS:000319830000001 PM 23718705 ER PT J AU Kalkstein, AJ AF Kalkstein, Adam J. TI Regional Similarities in Seasonal Mortality across the United States: An Examination of 28 Metropolitan Statistical Areas SO PLOS ONE LA English DT Article ID INFLUENZA-VIRUS; HEAT WAVES; MYOCARDIAL-INFARCTION; US CITIES; TEMPERATURE; TRANSMISSION; DEATHS; POPULATION; ADMISSIONS; HUMIDITY AB Human mortality exhibits a strong seasonal pattern with deaths in winter far exceeding those in the summer. While the pattern itself is clear, there have been very few studies examining whether the magnitude or timing of seasonal mortality varies considerably across space. Thus, the goal of this study is to conduct a comprehensive geographic analysis of seasonal mortality across the United States and to uncover systematic regional differences in such mortality. Unique seasonal mortality curves were created for 28 metropolitan statistical areas across the United States, and the amplitude and timing of mortality peaks were determined. The findings here indicate that the seasonality of mortality exhibits strong spatial variation with the largest seasonal mortality amplitudes found in the southwestern United States and the smallest in the North, along with South Florida. In addition, there were strong intra-regional similarities that exist among the examined cities, implying that environmental factors are more important than social factors in determining seasonal mortality response. This work begins to fill a large gap within the scientific literature concerning the geographic variation and underlying causes of seasonal mortality across the United States. C1 US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Kalkstein, AJ (reprint author), US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. EM Adam.Kalkstein@usma.edu FU National Research Council; Davies Fellowship Program FX This research was not funded. At present, Adam J. Kalkstein is being funded through the National Research Council's Davies Fellowship (http://sites.nationalacademies.org/PGA/RAP/PGA_050493), but this work was conducted prior to receiving the fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; I would like to thank Dr. Thomas DeFelice and the U.S. Army Research Laboratory for their assistance with this project, along with the Center for the Study of Civil-Military Operations at the United States Military Academy and the Davies Fellowship Program. I would also like to express my sincere gratitude to my Ph.D. advisor, Dr. Robert Balling, Jr. at Arizona State University, where this research commenced. NR 40 TC 4 Z9 4 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 29 PY 2013 VL 8 IS 5 AR e63971 DI 10.1371/journal.pone.0063971 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 155DJ UT WOS:000319725500089 PM 23734179 ER PT J AU Tomaras, GD Ferrari, G Shen, XY Alam, SM Liao, HX Pollara, J Bonsignori, M Moody, MA Fong, YY Chen, X Poling, B Nicholson, CO Zhang, RJ Lu, XZ Parks, R Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Gilbert, PB Kim, JH Michael, NL Montefiori, DC Haynes, BF AF Tomaras, Georgia D. Ferrari, Guido Shen, Xiaoying Alam, S. Munir Liao, Hua-Xin Pollara, Justin Bonsignori, Mattia Moody, M. Anthony Fong, Youyi Chen, Xi Poling, Brigid Nicholson, Cindo O. Zhang, Ruijun Lu, Xiaozhi Parks, Robert Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Rerks-Ngarm, Supachai Gilbert, Peter B. Kim, Jerome H. Michael, Nelson L. Montefiori, David C. Haynes, Barton F. TI Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID BROADLY NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODY; EFFICACY TRIAL; FC-RECEPTORS; RESPONSES; MEMBRANE; EPITOPES; INFECTION; AFFINITY; GP120 AB Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 inversely correlated with risk, whereas HIV-1 Env-specific plasma IgA responses directly correlated with risk. In the secondary analysis, antibody-dependent cellular cytotoxicity (ADCC) was another inverse correlate of risk, but only in the presence of low plasma IgA Env-specific antibodies. Thus, we investigated the hypothesis that IgA could attenuate the protective effect of IgG responses through competition for the same Env binding sites. We report that Env-specific plasma IgA/IgG ratios are higher in infected than in uninfected vaccine recipients in RV144. Moreover, Env-specific IgA antibodies from RV144 vaccinees blocked the binding of ADCC-mediating mAb to HIV-1 Env glycoprotein 120 (gp120). An Env-specific monomeric IgA mAb isolated from an RV144 vaccinee also inhibited the ability of natural killer cells to kill HIV-1-infected CD4(+) T cells coated with RV144-induced IgG antibodies. We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function. C1 [Tomaras, Georgia D.; Ferrari, Guido; Shen, Xiaoying; Alam, S. Munir; Liao, Hua-Xin; Pollara, Justin; Bonsignori, Mattia; Moody, M. Anthony; Chen, Xi; Zhang, Ruijun; Lu, Xiaozhi; Parks, Robert; Montefiori, David C.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Tomaras, Georgia D.; Ferrari, Guido; Pollara, Justin; Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA. [Tomaras, Georgia D.; Poling, Brigid; Nicholson, Cindo O.] Duke Univ, Med Ctr, Dept Microbiol & Mol Genet, Durham, NC 27710 USA. [Shen, Xiaoying; Alam, S. Munir; Liao, Hua-Xin; Bonsignori, Mattia; Zhang, Ruijun; Lu, Xiaozhi; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Moody, M. Anthony] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA. [Fong, Youyi; Gilbert, Peter B.] Statist Ctr HIV AIDS Res & Prevent, Seattle, WA 98109 USA. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10400, Thailand. [Nitayaphan, Sorachai; Kim, Jerome H.; Michael, Nelson L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Tomaras, GD (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. EM gdt@duke.edu; gflmp@duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016; OI Moody, Tony/0000-0002-3890-5855 FU Center for HIV/AIDS Vaccine Immunology (CHAVI)-Immunogen Discovery Grant [U01 AI067854]; National Institutes of Health, National Institute of Allergy and Infectious Diseases Division of Acquired Immunodeficiency Syndrome (NIH/NIAID/DAIDS); NIH NIAID [AI07392]; Bill and Melinda Gates Foundation [1033098, 1040758]; Collaboration for AIDS Vaccine Discovery-Vaccine Immune Monitoring Consortium (CAVD-VIMC) Grant [3830913]; CAVD-VIMC Grant [CTVIMC OPP1032325]; HIV-1 Vaccine Trials Network [5U01 AI46725-05]; Duke University Center for AIDS Research [P30 AI64518]; US Army Medical Research and Material Command [Y1-AI-2642-12]; NIAID [Y1-AI-2642-12, W81XWH-07-2-0067]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.; US Department of Defense FX We are indebted to the volunteers and clinical staff who participated in the RV144 vaccine trial. We thank Drs. Merlin Robb, Robert O'Connell, Kelly A. Soderberg, and Charla Andrews for clinical trial and/or project management, Dr. Nicole L. Yates and R. Glenn Overman for technical expertise, and Dr. Sarzotti-Kelsoe for quality assurance oversight. This work was supported by the Center for HIV/AIDS Vaccine Immunology (CHAVI)-Immunogen Discovery Grant U01 AI067854; National Institutes of Health, National Institute of Allergy and Infectious Diseases Division of Acquired Immunodeficiency Syndrome (NIH/NIAID/DAIDS); NIH NIAID Grant AI07392; Bill and Melinda Gates Foundation Grants 1033098 and 1040758; Collaboration for AIDS Vaccine Discovery-Vaccine Immune Monitoring Consortium (CAVD-VIMC) Grant 3830913, CAVD-VIMC Grant CTVIMC OPP1032325, HIV-1 Vaccine Trials Network 5U01 AI46725-05; and the Duke University Center for AIDS Research Grant P30 AI64518. Funding was also provided by Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research and Material Command and the NIAID through cooperative agreement W81XWH-07-2-0067 between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. NR 32 TC 131 Z9 131 U1 1 U2 20 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 28 PY 2013 VL 110 IS 22 BP 9019 EP 9024 DI 10.1073/pnas.1301456110 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 165RC UT WOS:000320500000067 PM 23661056 ER PT J AU Cerco, CF Threadgill, T Noel, MR Hinz, S AF Cerco, Carl F. Threadgill, Tammy Noel, Mark R. Hinz, Scott TI Modeling the pH in the tidal fresh Potomac River under conditions of varying hydrology and loads SO ECOLOGICAL MODELLING LA English DT Article DE pH; Alkalinity; Carbonate cycle; Potomac River; Cyanobacteria ID SEDIMENT NUTRIENT FLUXES; CHESAPEAKE BAY; WATER-QUALITY; ALGAL GROWTH; ESTUARY; CARBON; EUTROPHICATION; ACIDIFICATION; CYANOBACTERIA; EMBAYMENT AB The pH of the freshwater portion of the Potomac River estuary attains 9-10.5, driven by photosynthesis during cyanobacteria blooms. Processes which contribute to elevated pH are examined by adding a mass-balance model of the carbonate cycle to an existing eutrophication model. Four new variables are added to the model suite: alkalinity, total inorganic carbon, total calcium, and calcium carbonate. The pH is computed from these four quantities via equilibrium kinetics. The model is employed in a continuous simulation of the years 1994-2000. Emphasis in examination of model results is placed on the tidal fresh portion of the system where elevated pH is an environmental concern. Model sensitivity analysis indicates hydrology has the greatest influence on pH. During low-flow periods, residence time is lengthy allowing ample time for algal production to occur. The production stimulates net uptake of TIC, and results in enhanced pH. Published by Elsevier B.V. C1 [Cerco, Carl F.; Threadgill, Tammy; Noel, Mark R.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hinz, Scott] Limnotech Inc, Austin, TX 78731 USA. RP Cerco, CF (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil; tammy.l.threadgill@usace.army.mil; mark.r.noel@usace.army.mil; shinz@limno.com FU US Environmental Protection Agency Chesapeake Bay Program FX The authors thank Dominic DiToro for pointing out the influence of the ALK/TIC ratio on pH. The pH-alkalinity algorithms employed here were initially developed by Dominic DiToro and James Fitzpatrick. The phytoplankton component of the model was parameterized by Victor Bierman and Amanda Flynn. R. Christian Jones contributed observations collected in Gunston Cove and adjacent waters. This study was sponsored by the US Environmental Protection Agency Chesapeake Bay Program. NR 48 TC 3 Z9 3 U1 0 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD MAY 24 PY 2013 VL 257 BP 101 EP 112 DI 10.1016/j.ecolmodel.2013.02.011 PG 12 WC Ecology SC Environmental Sciences & Ecology GA 135XH UT WOS:000318323500010 ER PT J AU Patel, G Karver, CE Behera, R Guyett, PJ Sullenberger, C Edwards, P Roncal, NE Mensa-Wilmot, K Pollastri, MP AF Patel, Gautam Karver, Caitlin E. Behera, Ranjan Guyett, Paul J. Sullenberger, Catherine Edwards, Peter Roncal, Norma E. Mensa-Wilmot, Kojo Pollastri, Michael P. TI Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID HUMAN AFRICAN TRYPANOSOMIASIS; IN-VITRO; PHARMACOLOGICAL VALIDATION; BRUCEI PHOSPHODIESTERASES; SLEEPING SICKNESS; PROTEIN-KINASES; CELL-CYCLE; INHIBITORS; ENDOCYTOSIS; GROWTH AB Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Because drugs in use against HAT are toxic and require intravenous dosing, new drugs are needed. Initiating lead discovery campaigns by using chemical scaffolds from drugs approved for other indications can speed up drug discovery for neglected diseases. We demonstrated recently that the 4-anilinoquinazolines lapatinib (GW572016, 1) and canertinib (CI-1033) kill T. brucei with low micromolar EC50 values. We now report promising activity of analogues of 1, which provided an excellent starting point for optimization of the chemotype. Our compound optimization that has led to synthesis of several potent 4-anilinoquinazolines, including NEU617, 23a, a highly potent, orally bioavailable inhibitor of trypanosome replication. At the cellular level, 23a blocks duplication of the kinetoplast and arrests cytokinesis, making it a new chemical tool for studying regulation of the trypanosome cell cycle. C1 [Patel, Gautam; Karver, Caitlin E.; Edwards, Peter; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Patel, Gautam; Karver, Caitlin E.; Edwards, Peter; Pollastri, Michael P.] Northeastern Univ, Ctr Drug Discovery, Boston, MA 02115 USA. [Behera, Ranjan; Guyett, Paul J.; Sullenberger, Catherine; Mensa-Wilmot, Kojo] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA. [Roncal, Norma E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. EM mensawil@uga.edu; m.pollastri@neu.edu OI Guyett, Paul/0000-0001-8538-1954; pollastri, Michael/0000-0001-9943-7197 FU National Institutes of Health [R01AI082577, R21AI076647]; National Science Foundation [MCB-0843603]; Northeastern University FX Funding from the National Institutes of Health (R01AI082577 to M.P., and R21AI076647 to K.M.-W.), the National Science Foundation (MCB-0843603), Northeastern University, and a gift of compounds (Table 1) from GlaxoSmithKline, Inc.. is gratefully acknowledged. We appreciate helpful discussions with Dr. Richard Sciotti at Walter Reed Army Institute of Research and Dr. Franco Lombardo at Novartis. NR 50 TC 27 Z9 27 U1 3 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY 23 PY 2013 VL 56 IS 10 BP 3820 EP 3832 DI 10.1021/jm400349k PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 154CW UT WOS:000319650100005 PM 23597080 ER PT J AU Wang, GS Hu, N Yang, HH Wang, LM Su, H Wang, CY Clifford, R Dawsey, EM Li, JM Ding, T Han, XY Giffen, C Goldstein, AM Taylor, PR Lee, MP AF Wang, Gangshi Hu, Nan Yang, Howard H. Wang, Lemin Su, Hua Wang, Chaoyu Clifford, Robert Dawsey, Erica M. Li, Jian-Min Ding, Ti Han, Xiao-You Giffen, Carol Goldstein, Alisa M. Taylor, Philip R. Lee, Maxwell P. TI Comparison of Global Gene Expression of Gastric Cardia and Noncardia Cancers from a High-Risk Population in China SO PLOS ONE LA English DT Article ID SQUAMOUS-CELL CARCINOMA; NUTRITION INTERVENTION TRIALS; DISEASE-SPECIFIC MORTALITY; CLINICAL-SIGNIFICANCE; DISTINCTIVE PATTERNS; SOMATIC MUTATIONS; FAMILY-HISTORY; ESOPHAGEAL; LINXIAN; SUPPLEMENTATION AB Objective: To profile RNA expression in gastric cancer by anatomic subsites as an initial step in identifying molecular subtypes and providing targets for early detection and therapy. Methods: We performed transcriptome analysis using the Affymetrix GeneChip U133A in gastric cardia adenocarcinomas (n = 62) and gastric noncardia adenocarcinomas (n = 72) and their matched normal tissues from patients in Shanxi Province, and validated selected dysregulated genes with additional RNA studies. Expression of dysregulated genes was also related to survival of cases. Results: Principal Component Analysis showed that samples clustered by tumor vs. normal, anatomic location, and histopathologic features. Paired t-tests of tumor/normal tissues identified 511 genes whose expression was dysregulated (P<4.7E-07 and at least two-fold difference in magnitude) in cardia or noncardia gastric cancers, including nearly one-half (n = 239, 47%) dysregulated in both cardia and noncardia, one-fourth dysregulated in cardia only (n = 128, 25%), and about one-fourth in noncardia only (n = 144, 28%). Additional RNA studies confirmed profiling results. Expression was associated with case survival for 20 genes in cardia and 36 genes in noncardia gastric cancers. Conclusions: The dysregulated genes identified here represent a comprehensive starting point for future efforts to understand etiologic heterogeneity, develop diagnostic biomarkers for early detection, and test molecularly-targeted therapies for gastric cancer. C1 [Wang, Gangshi; Hu, Nan; Wang, Lemin; Su, Hua; Wang, Chaoyu; Dawsey, Erica M.; Goldstein, Alisa M.; Taylor, Philip R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Yang, Howard H.; Lee, Maxwell P.] NCI, Off Director, Ctr Canc Res, Bethesda, MD 20892 USA. [Clifford, Robert] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Li, Jian-Min; Ding, Ti; Han, Xiao-You] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China. [Giffen, Carol] Informat Management Serv Inc, Silver Spring, MD USA. RP Taylor, PR (reprint author), NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. EM ptaylor@mail.nih.gov; leemax@mail.nih.gov FU National Institutes of Health; Center for Cancer Research; National Cancer Institute, the Division of Cancer Epidemiology and Genetics FX This research is funded by the Intramural Research Program of the National Institutes of Health, the National Cancer Institute, the Division of Cancer Epidemiology and Genetics, and the Center for Cancer Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 17 Z9 18 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 22 PY 2013 VL 8 IS 5 AR UNSP e63826 DI 10.1371/journal.pone.0063826 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 163UP UT WOS:000320362700068 PM 23717493 ER PT J AU Chaudhury, S Abdulhameed, MDM Singh, N Tawa, GJ D'haeseleer, PM Zemla, AT Navid, A Zhou, CE Franklin, MC Cheung, J Rudolph, MJ Love, J Graf, JF Rozak, DA Dankmeyer, JL Amemiya, K Daefler, S Wallqvist, A AF Chaudhury, Sidhartha Abdulhameed, Mohamed Diwan M. Singh, Narender Tawa, Gregory J. D'haeseleer, Patrik M. Zemla, Adam T. Navid, Ali Zhou, Carol E. Franklin, Matthew C. Cheung, Jonah Rudolph, Michael J. Love, James Graf, John F. Rozak, David A. Dankmeyer, Jennifer L. Amemiya, Kei Daefler, Simon Wallqvist, Anders TI Rapid Countermeasure Discovery against Francisella tularensis Based on a Metabolic Network Reconstruction SO PLOS ONE LA English DT Article ID MYCOBACTERIUM-TUBERCULOSIS; ESCHERICHIA-COLI; DRUG TARGETS; PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE; CHORISMATE SYNTHASE; ACCURATE DOCKING; SYSTEMS BIOLOGY; IN-SILICO; INHIBITORS; DATABASE AB In the future, we may be faced with the need to provide treatment for an emergent biological threat against which existing vaccines and drugs have limited efficacy or availability. To prepare for this eventuality, our objective was to use a metabolic network-based approach to rapidly identify potential drug targets and prospectively screen and validate novel small-molecule antimicrobials. Our target organism was the fully virulent Francisella tularensis subspecies tularensis Schu S4 strain, a highly infectious intracellular pathogen that is the causative agent of tularemia and is classified as a category A biological agent by the Centers for Disease Control and Prevention. We proceeded with a staggered computational and experimental workflow that used a strain-specific metabolic network model, homology modeling and X-ray crystallography of protein targets, and ligand- and structure-based drug design. Selected compounds were subsequently filtered based on physiological-based pharmacokinetic modeling, and we selected a final set of 40 compounds for experimental validation of antimicrobial activity. We began screening these compounds in whole bacterial cell-based assays in biosafety level 3 facilities in the 20th week of the study and completed the screens within 12 weeks. Six compounds showed significant growth inhibition of F. tularensis, and we determined their respective minimum inhibitory concentrations and mammalian cell cytotoxicities. The most promising compound had a low molecular weight, was non-toxic, and abolished bacterial growth at 13 mu M, with putative activity against pantetheine-phosphate adenylyltransferase, an enzyme involved in the biosynthesis of coenzyme A, encoded by gene coaD. The novel antimicrobial compounds identified in this study serve as starting points for lead optimization, animal testing, and drug development against tularemia. Our integrated in silico/in vitro approach had an overall 15% success rate in terms of active versus tested compounds over an elapsed time period of 32 weeks, from pathogen strain identification to selection and validation of novel antimicrobial compounds. C1 [Chaudhury, Sidhartha; Abdulhameed, Mohamed Diwan M.; Singh, Narender; Tawa, Gregory J.; Wallqvist, Anders] USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA. [D'haeseleer, Patrik M.; Zemla, Adam T.; Navid, Ali; Zhou, Carol E.] Lawrence Livermore Natl Lab, Livermore, CA USA. [Franklin, Matthew C.; Cheung, Jonah; Rudolph, Michael J.; Love, James] New York Struct Biol Ctr, New York, NY USA. [Graf, John F.] GE Co, GE Global Res, Diagnost & Biomed Technol, Computat Biol & Biostat Lab, Niskayuna, NY USA. [Rozak, David A.; Dankmeyer, Jennifer L.; Amemiya, Kei] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Daefler, Simon] Mt Sinai Sch Med, New York, NY USA. RP Wallqvist, A (reprint author), USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA. EM awallqvist@bhsai.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015; OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency [TMTI0004.09.BH.T, HDTRA1-08-C-0052, TMTI10049.09.RD.T, W911SR-11-C-0014] FX This work was supported by the Defense Threat Reduction Agency through projects TMTI0004.09.BH.T, HDTRA1-08-C-0052, TMTI10049.09.RD.T, and W911SR-11-C-0014. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 70 TC 2 Z9 2 U1 1 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 21 PY 2013 VL 8 IS 5 AR e63369 DI 10.1371/journal.pone.0063369 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 149OK UT WOS:000319330200030 PM 23704901 ER PT J AU Berry, JS Trappey, AF Sears, AK Vreeland, TJ Clifton, GT Hale, DF Patil, R Holmes, JP Ponniah, S Mittendorf, EA Peoples, GE Van Echo, DC AF Berry, John S. Trappey, Alfred F. Sears, Alan K. Vreeland, Timothy J. Clifton, Guy T. Hale, Diane F. Patil, Ritesh Holmes, Jarrod P. Ponniah, Sathibalan Mittendorf, Elizabeth Ann Peoples, George Earl Van Echo, David C. TI Biomarker correlation to clinical response in phase I/II trials of the adjuvant breast cancer vaccine neuvax (nelipepimut-S or E75) SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 31-JUN 04, 2013 CL Chicago, IL SP Amer Soc Clin Oncol C1 Brooke Army Med Ctr, San Antonio, TX USA. Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA. Naval Med Ctr San Diego, San Diego, CA USA. USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2013 VL 31 IS 15 SU S MA TPS3126 PG 1 WC Oncology SC Oncology GA AG4VY UT WOS:000335419605420 ER PT J AU Patil, R Clifton, GT Litton, JK Shumway, NM Vreeland, TJ Berry, JS Trappey, AF Ponniah, S Peoples, GE Mittendorf, EA AF Patil, Ritesh Clifton, Guy T. Litton, Jennifer Keating Shumway, Nathan M. Vreeland, Timothy J. Berry, John S. Trappey, Alfred F. Ponniah, Sathibalan Peoples, George Earl Mittendorf, Elizabeth Ann TI Safety and efficacy of the HER2-derived GP2 peptide vaccine in combination with trastuzumab for breast cancer patients in the adjuvant setting. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 31-JUN 04, 2013 CL Chicago, IL SP Amer Soc Clin Oncol C1 Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA. Blanchfield Army Community Hosp, Ft Campbell, KY USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2013 VL 31 IS 15 SU S MA 3096 PG 1 WC Oncology SC Oncology GA AG4VY UT WOS:000335419601228 ER PT J AU Steele, S Bilchik, A Johnson, E Nissan, A Peoples, GE Eberhardt, J Kalina, P Petersen, B Bruecher, BLDM Protic, M Avital, I Stojadinovic, A AF Steele, Scott Bilchik, Anton Johnson, Eric Nissan, Aviram Peoples, George Earl Eberhardt, John Kalina, Philip Petersen, Benjamin Bruecher, Bjoern L. D. M. Protic, Mladjan Avital, Itzhak Stojadinovic, Alexander TI Time-dependent estimates of recurrence and survival in colon cancer: clinical decision support system tool development for adjuvant therapy and oncological outcome assessment. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 31-JUN 04, 2013 CL Chicago, IL SP Amer Soc Clin Oncol C1 Madigan Army Med Ctr, Tacoma, WA USA. John Wayne Canc Inst, Santa Monica, CA USA. Hadassah Univ Hosp Mt Scopus, Jerusalem, Israel. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. DecisionQ Corp, Washington, DC USA. Theodor Billroth Acad, Int Consortium Res Excellence, Munich, Germany. US Mil Canc Inst, Washington, DC USA. Bon Secours Canc Inst, Richmond, VA USA. Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2013 VL 31 IS 15 SU S MA e14500 PG 1 WC Oncology SC Oncology GA AG4VY UT WOS:000335419603482 ER PT J AU Trappey, AF Berry, JS Vreeland, TJ Hale, DF Sears, AK Ponniah, S Perez, SA Clifton, GT Papamichail, M Shumway, NM Mittendorf, EA Peoples, GE AF Trappey, Alfred F. Berry, John S. Vreeland, Timothy J. Hale, Diane F. Sears, Alan K. Ponniah, Sathibalan Perez, Sonia A. Clifton, Guy T. Papamichail, Michael Shumway, Nathan M. Mittendorf, Elizabeth Ann Peoples, George Earl TI Risk factors for development of delayed urticarial reactions in the phase II trial of HER2 peptide vaccines plus GM-CSF versus GM-CSF alone in high-risk breast cancer patients to prevent recurrence. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 31-JUN 04, 2013 CL Chicago, IL SP Amer Soc Clin Oncol C1 Brooke Army Med Ctr, San Antonio, TX USA. USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA. St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece. Canc Immunol & Immunotherapy Ctr, Athens, Greece. San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2013 VL 31 IS 15 SU S MA 3097 PG 1 WC Oncology SC Oncology GA AG4VY UT WOS:000335419601229 ER PT J AU Trappey, F Berry, JS Vreeland, TJ Hale, DF Sears, AK Ponniah, S Perez, SA Clifton, GT Papamichail, M Peoples, GE Mittendorf, EA AF Trappey, Francois Berry, John S. Vreeland, Timothy J. Hale, Diane F. Sears, Alan K. Ponniah, Sathibalan Perez, Sonia A. Clifton, Guy T. Papamichail, Michael Peoples, George Earl Mittendorf, Elizabeth Ann TI Randomized phase II clinical trial of the anti-HER2 (GP2) vaccine to prevent recurrence in high-risk breast cancer patients: A planned interim analysis. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 31-JUN 04, 2013 CL Chicago, IL SP Amer Soc Clin Oncol C1 Brooke Army Med Ctr, San Antonio, TX USA. USUHS, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA. St Savas Canc Hosp, Athens, Greece. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Canc Immunol & Immunotherapy Ctr, Athens, Greece. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2013 VL 31 IS 15 SU S MA 3005 PG 1 WC Oncology SC Oncology GA AG4VY UT WOS:000335419601138 ER PT J AU Bogle, X Vazquez, R Greenbaum, S Cresce, AV Xu, K AF Bogle, Xavier Vazquez, Rafael Greenbaum, Steven Cresce, Arthur von Wald Xu, Kang TI Understanding Li+-Solvent Interaction in Nonaqueous Carbonate Electrolytes with O-17 NMR SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID GRAPHITE/ELECTROLYTE INTERFACE; SOLVATION SHEATH; LITHIUM-ION; BATTERIES; GRAPHITE; SYSTEMS; CELLS AB To understand how Li+ interacts with individual carbonate molecules in nonaqueous electrolytes, we conducted natural abundance O-17 NMR measurements on electrolyte solutions of 1 M LiPF6 in a series of binary solvent mixtures of ethylene carbonate (EC) and dimethyl carbonate (DMC). It was observed that the largest changes in O-17 chemical shift occurred at the carbonyl oxygens of EC, firmly establishing that Li+ strongly prefers EC over DMC in typical nonaqueous electrolytes, while mainly coordinating with carbonyl rather than ethereal oxygens. Further quantitative analysis of the displacements in O-17 chemical shifts renders a detailed Li+-solvation structure in these electrolyte solutions, revealing that maximum six EC molecules can coexist in the Li+-solvation sheath, while DMC association with Li+ is more "noncommittal" but simultaneously prevalent. This discovery, while aligning well with previous fragmental knowledge about Li+-solvation, reveals for the first time a complete picture of Li+ solvation structure in nonaqueous electrolytes. C1 [Bogle, Xavier; Vazquez, Rafael; Greenbaum, Steven] CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA. [Vazquez, Rafael; Greenbaum, Steven] CUNY, Grad Ctr, New York, NY 10065 USA. [Vazquez, Rafael; Greenbaum, Steven] CUNY, Grad Ctr, New York, NY 10016 USA. [Cresce, Arthur von Wald; Xu, Kang] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP Greenbaum, S (reprint author), CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA. EM steve.greenbaum@hunter.cuny.edu; conrad.k.xu.civ@mail.mil RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 FU Army Research Office [W911NF-12-2-0059]; National Institutes of Health RCMI infrastructure grant [RR 003037] FX This work was supported by Army Research Office under contract number W911NF-12-2-0059. The Hunter College NMR facility is supported by a National Institutes of Health RCMI infrastructure grant (RR 003037). We thank Dr. Matthew Devany of the NMR facility for technical assistance. NR 21 TC 47 Z9 49 U1 6 U2 60 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD MAY 16 PY 2013 VL 4 IS 10 BP 1664 EP 1668 DI 10.1021/jz400661k PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 183DI UT WOS:000321793800015 PM 26282976 ER PT J AU Krishnani, KK Srinives, S Mohapatra, BC Boddu, VM Hao, JM Meng, X Mulchandani, A AF Krishnani, K. K. Srinives, Sira Mohapatra, B. C. Boddu, V. M. Hao, Jumin Meng, X. Mulchandani, Ashok TI Hexavalent chromium removal mechanism using conducting polymers SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Conducting polymers; Cr(VI) remediation; Mechanism; Chemical reduction ID HEAVY-METALS; PALLADIUM NANOPARTICLES; REDUCTION; CR(VI); POLYANILINE; POLYPYRROLE; DEGRADATION; ANILINE; WASTE; WATER AB We report detoxification of Cr(VI) into Cr(III) using electrochemically synthesized polyaniline (PANI), polypyrrole (PPY), PANI nanowires (PANI-NW) and palladium-decorated PANI (PANI-Pd) thin films. Percent Cr(VI) reduction was found to be decreased with an increase in pH from 1.8 to 6.8 and with initial Cr(VI) concentration ranging from 2.5 to 10 mg/L. Efficacy of PANI increased at higher temp of 37 degrees C as compared to 30 degrees C. PANI-Pd was found to be most effective for all three initial Cr(VI) concentrations at pH 1.8. However, efficacy of PANI-Pd was significantly reduced at higher pHs of 5 and 6.8. Efficacy of PANI and PANI-NW was found to nearly the same. However, there was a significant reduction in effectiveness of PANI-NW at 10 mg/L of Cr(VI) at all the three pHs studied, which could be attributed to degradation of PANI-NW by higher initial Cr(VI) concentration. PPY and PANI-NW were found to be highly sensitive with respect to pH and Cr(VI) initial concentration. Chromium speciation on PANI film was carried out by total chromium analysis and XPS, which revealed Cr(III) formation and its subsequent adsorption on the polymer. PANI-Pd and PANI are recommended for future sensor applications for chromium detection at low pH. (c) 2013 Elsevier B.V. All rights reserved. C1 [Krishnani, K. K.; Srinives, Sira; Mohapatra, B. C.; Mulchandani, Ashok] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA. [Krishnani, K. K.] Natl Inst Abiot Stress Management, Pune 413115, Maharashtra, India. [Srinives, Sira] Mahidol Univ, Dept Chem Engn, Nakhon Pathom 73170, Thailand. [Mohapatra, B. C.] Cent Inst Freshwater Aquaculture, Bhubaneswar, Orissa, India. [Boddu, V. M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Hao, Jumin; Meng, X.] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. RP Mulchandani, A (reprint author), Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA. EM adani@engr.ucr.edu RI Mulchandani, Ashok/B-9692-2016 OI Mulchandani, Ashok/0000-0002-2831-4154 FU HRD-NAIP Programme of ICAR, New Delhi; Thai Government Scholarship, Ministry of Science and Technology, Thailand FX Dr. K.K. Krishnani and Dr B.C. Mohapatra acknowledge the financial support from HRD-NAIP Programme of ICAR, New Delhi. Sira Srinives acknowledges the Thai Government Scholarship, Ministry of Science and Technology, Thailand. NR 31 TC 30 Z9 30 U1 2 U2 104 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAY 15 PY 2013 VL 252 BP 99 EP 106 DI 10.1016/j.jhazmat.2013.01.079 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 162TL UT WOS:000320288800013 PM 23507365 ER PT J AU Adams, SM Bornemann, PH AF Adams, Stephen M. Bornemann, Paul H. TI Ulcerative Colitis SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID INFLAMMATORY-BOWEL-DISEASE; OF-THE-LITERATURE; DOUBLE-BLIND; MAINTAINING REMISSION; THERAPY; METAANALYSIS; PROCTITIS; EFFICACY; PREVALENCE; MESALAZINE AB Ulcerative colitis is a chronic inflammatory disease of the colon. The etiology is unknown. Risk factors include a history of recent infection with Salmonella or Campylobacter, living in Western industrialized nations and at higher latitudes, and a family history of the disease. The incidence peaks in early adulthood, but patients can develop the disorder from early childhood through adulthood. Ulcerative colitis often presents with abdominal pain, diarrhea, and hematochezia. It is important to exclude infectious etiologies. Anemia and an elevated erythrocyte sedimentation rate or C-reactive protein level may suggest inflammatory bowel disease, but the absence of laboratory abnormalities does not rule out ulcerative colitis. The diagnosis is suspected clinically and confirmed through endoscopic biopsy. First-line treatment is therapy with 5-aminosalicylic acid. Corticosteroids may be added if 5-aminosalicylic acid therapy is ineffective. Infliximab can be added to induce and sustain remission. Patients with severe or nonresponsive ulcerative colitis should be hospitalized, and intravenous corticosteroids should be given. If medical management has been ineffective, surgical intervention is indicated for severe disease. Patients with ulcerative colitis have an increased risk of colon cancer and should have periodic colonoscopy beginning eight to 10 years after diagnosis. Copyright (C) 2013 American Academy of Family Physicians. C1 [Adams, Stephen M.] Univ Tennessee, Coll Med, Chattanooga, TN 37403 USA. [Bornemann, Paul H.] Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA. [Bornemann, Paul H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Adams, SM (reprint author), Univ Tennessee, Coll Med, 1100 E 3rd St,Ste 101, Chattanooga, TN 37403 USA. EM stephen.adams@erlanger.org NR 40 TC 12 Z9 15 U1 1 U2 3 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAY 15 PY 2013 VL 87 IS 10 BP 699 EP 705 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 150FA UT WOS:000319374400004 PM 23939448 ER PT J AU Zarling, S Berenzon, D Dalai, S Liepinsh, D Steers, N Krzych, U AF Zarling, Stasya Berenzon, Dmitriy Dalai, Sarat Liepinsh, Dmitry Steers, Nick Krzych, Urszula TI The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates with Sustained Protection Against Malaria SO JOURNAL OF IMMUNOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM SPOROZOITES; INFLUENZA-VIRUS INFECTION; CIRCUMSPOROZOITE PROTEIN; ANTIGEN PRESENTATION; BERGHEI SPOROZOITES; IMMUNE-RESPONSES; DENDRITIC CELLS; STAGE MALARIA; LIVER STAGES; HOMEOSTATIC PROLIFERATION AB Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably linked to long-lasting protective immunity. Studies of protective immunity among residents of malaria endemic areas indicate that memory responses to Plasmodium Ags are not adequately developed or maintained, as people who survive episodes of childhood malaria are still vulnerable to either persistent or intermittent malaria infections. In contrast, multiple exposures to radiation-attenuated Plasmodium berghei sporozoites (Pb gamma-spz) induce long-lasting protective immunity to experimental sporozoite challenge. We previously demonstrated that sterile protection induced by Pb gamma-spz is MHC class I-dependent and CD8 T cells are the key effectors. IFN-gamma(+) CD8 T cells that arise in Pb gamma-spz-immunized B6 mice are found predominantly in the liver and are sensitive to levels of liver-stage Ag depot and they express CD44(hi)CD62L(lo) markers indicative of effector/effector memory phenotype. The developmentally related central memory CD8 T (T-CM) cells express elevated levels of CD122 (IL-15R beta), which suggests that CD8 T-CM cells depend on IL-15 for maintenance. Using IL-15-deficient mice, we demonstrate in this study that although protective immunity is inducible in these mice, protection is short-lived, mainly owing to the inability of CD8 T-CM cells to survive in the IL-15-deficient milieu. We present a hypothesis consistent with a model whereby intrahepatic CD8 T-CM cells, being maintained by IL-15-mediated survival and basal proliferation, are conscripted into the CD8 effector/effector memory T cell pool during subsequent infections. C1 [Zarling, Stasya; Berenzon, Dmitriy; Dalai, Sarat; Liepinsh, Dmitry; Steers, Nick; Krzych, Urszula] Walter Reed Army Inst Res, Dept Cellular Immunol, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Cellular Immunol, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ukrzych@gmail.com FU National Institutes of Health [AI 46438]; U.S. Army Materiel Command FX The work was supported in part by National Institutes of Health Grant AI 46438 (to U.K.) and by the U.S. Army Materiel Command. S.Z. is a National Research Council Research Associate. NR 73 TC 19 Z9 20 U1 0 U2 4 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 15 PY 2013 VL 190 IS 10 BP 5128 EP 5141 DI 10.4049/jimmunol.1203396 PG 14 WC Immunology SC Immunology GA 138YB UT WOS:000318546700024 PM 23589611 ER PT J AU Amorim, RG Zhong, XL Mukhopadhyay, S Pandey, R Rocha, AR Karna, SP AF Amorim, Rodrigo G. Zhong, Xiaoliang Mukhopadhyay, Saikat Pandey, Ravindra Rocha, Alexandre R. Karna, Shashi P. TI Strain- and electric field-induced band gap modulation in nitride nanomembranes SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID BORON-NITRIDE; SILICON NANOMEMBRANES; ELASTIC-CONSTANTS; GRAPHENE; FABRICATION; PRESSURE; DEVICES; ALN AB The hexagonal nanomembranes of the group III-nitrides are a subject of interest due to their novel technological applications. In this paper, we investigate the strain- and electric field-induced modulation of their band gaps in the framework of density functional theory. For AlN, the field-dependent modulation of the bandgap is found to be significant whereas the strain-induced semiconductor-metal transition is predicted for GaN. A relatively flat conduction band in AlN and GaN nanomembranes leads to an enhancement of their electronic mobility compared to that of their bulk counterparts. C1 [Amorim, Rodrigo G.; Zhong, Xiaoliang; Mukhopadhyay, Saikat; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Rocha, Alexandre R.] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP, Brazil. [Rocha, Alexandre R.] Univ Estadual Paulista UNESP, Inst Fis Teor, Sao Paulo, Brazil. [Karna, Shashi P.] USA, Ballist Res Lab, Weap & Mat Res Directorate, ATTN RDL WM, Aberdeen Proving Ground, MD 21005 USA. RP Amorim, RG (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Mukhopadhyay, Saikat/B-4402-2011; Rocha, Alexandre/F-9504-2010; Amorim, Rodrigo /I-6173-2012; Zhong, Xiaoliang/B-2220-2012; Amorim, Rodrigo/N-4139-2016 OI Rocha, Alexandre/0000-0001-8874-6947; Amorim, Rodrigo/0000-0001-9611-8772 FU CNPQ; FAPESP; Army Research Office [W911NF-09-1-0221] FX We acknowledge support from Brazilian Agencies CNPQ and FAPESP and computational resources CENAPAD/SP and NACAD/UFRJ. The work at Michigan Technological University was performed under support by the Army Research Office through Contract Number W911NF-09-1-0221. NR 41 TC 11 Z9 11 U1 1 U2 38 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD MAY 15 PY 2013 VL 25 IS 19 AR 195801 DI 10.1088/0953-8984/25/19/195801 PG 7 WC Physics, Condensed Matter SC Physics GA 132LP UT WOS:000318070100022 PM 23604312 ER PT J AU Sviatenko, LK Gorb, L Hill, FC Leszczynski, J AF Sviatenko, Liudmyla K. Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI Theoretical study of ionization and one-electron oxidation potentials of N-heterocyclic compounds SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE redox potential; DFT calculations; N-heterocyclic compounds; electrochemistry; solvation ID SOLVATION FREE-ENERGIES; DENSITY FUNCTIONALS; THERMOCHEMICAL KINETICS; REDOX POTENTIALS; ACETONITRILE; COMPUTATION; DERIVATIVES; PREDICTION; ACCURATE; DESIGN AB A number of density functionals was utilized to predict gas-phase adiabatic ionization potentials (IPs) for nitrogen-rich heterocyclic compounds. Various solvation models were applied to the calculation of difference in free energies of solvation of oxidized and reduced forms of heterocyclic compounds in acetonitrile (AN) for correct reproduction of their standard oxidation potentials. We developed generally applicable protocols that could successfully predict the gas-phase adiabatic ionization potentials of nitrogen-rich heterocyclic compounds and their standard oxidation potentials in AN. This approach is supported by a MPW1K/6-31+G(d) level of theory which uses SMD(UA0) approximation for estimation of solvation energy of neutral molecules and PCM(UA0) model for ionized ones. The mean absolute derivation (MAD) and root mean square error (RMSE) of the current theoretical models for IP are equal to 0.22 V and 0.26, respectively, and for oxidation potentials MAD = 0.13 V and RMSE = 0.17. (c) 2013 Wiley Periodicals, Inc. C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Sviatenko, Liudmyla K.] Kirovohrad Volodymyr Vynnychenko State Pedag Univ, Dept Nat & Geog Sci, UA-25006 Kirovohrad, Ukraine. [Gorb, Leonid] Badger Tech Serv Inc, Huntsville, AL 35805 USA. [Hill, Frances C.] USA, Environm Lab, ERDC, Vicksburg, MS 39180 USA. RP Sviatenko, LK (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU National Science Foundation [NSF/CREST HRD 0833178]; EPSCoR [362492-190200-01\NSFEPS-090378] FX Contract/grant sponsor: National Science Foundation; Contract/grant number: NSF/CREST HRD 0833178; Contract/grant sponsor: EPSCoR Award; Contract/grant number: 362492-190200-01\NSFEPS-090378. NR 41 TC 11 Z9 11 U1 2 U2 45 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD MAY 15 PY 2013 VL 34 IS 13 BP 1094 EP 1100 DI 10.1002/jcc.23228 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 123ZO UT WOS:000317432400002 PM 23335274 ER PT J AU Rangasamy, E Wolfenstine, J Allen, J Sakamoto, J AF Rangasamy, Ezhiylmurugan Wolfenstine, Jeff Allen, Jan Sakamoto, Jeff TI The effect of 24c-site (A) cation substitution on the tetragonal-cubic phase transition in Li(7-x)La(3-x)A(x)Zr(2)O(12) garnet-based ceramic electrolyte SO JOURNAL OF POWER SOURCES LA English DT Article DE Solid-electrolyte; Garnet; Ce; Cubic; Li vacancies; Hot-pressing ID LITHIUM-ION BATTERIES; YTTRIUM-IRON-GARNET; SOLID-ELECTROLYTE; LI7LA3ZR2O12; CONDUCTIVITY; STATE; AL; TRANSPORT; GA AB The garnet-type ceramic electrolyte of nominal composition Li7La3Zr2O12 can exist in the tetragonal and cubic form. This article investigates the tetragonal to cubic phase transition based on super-valent cation substitution on the 24c site typically occupied by La (3+) in the garnet structure. Ce (4+) was selected as the super-valent cation represented as x in Li7-xLa3-xCexZr2O12. The doping study showed that cubic LLZO was stabilized for Ce >= 0.2. These data agree with most literature reports suggesting that the creation of Li vacancies, while maintaining oxygen stoichiometry, is necessary to stabilize cubic LLZO. Moreover, this work suggests a critical Li vacancy concentration (0.12-0.4 mol per mole of Li7La3Zr2O12) is necessary to stabilize cubic LLZO. While the addition of Ce stabilized cubic LLZO, the total ionic conductivity (0.014 mS cm(-1)) was considerably lower compared to Al and Ta doped LLZO (0.4-0.9 mS cm(-1), respectively). The lower conductivity is likely due to CeO2 precipitation at grain boundaries. (C) 2012 Elsevier B.V. All rights reserved. C1 [Rangasamy, Ezhiylmurugan; Allen, Jan; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM jsakamot@msu.edu RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU U.S. Army Research Office (ARO); U.S. Army Research Laboratory (ARL) FX Authors EL and JS would like to acknowledge the support of the U.S. Army Research Office (ARO). JW and JA would like to acknowledge support of the U.S. Army Research Laboratory (ARL). NR 30 TC 28 Z9 28 U1 17 U2 265 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAY 15 PY 2013 VL 230 BP 261 EP 266 DI 10.1016/j.jpowsour.2012.12.076 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 099FF UT WOS:000315606000037 ER PT J AU Kaplan, D Swaminathan, V Recine, G Balu, R Karna, S AF Kaplan, D. Swaminathan, V. Recine, G. Balu, R. Karna, S. TI Bandgap tuning of mono- and bilayer graphene doped with group IV elements SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HEXAGONAL BORON-NITRIDE; EPITAXIAL GRAPHENE; TUNABLE BANDGAP; ELECTRIC-FIELD; GAP AB We report density functional theory band structure calculations of graphene doped with group IV elements. A bandgap as high as 2.13 eV is calculated for a single layer of graphene doped with Si while Ge and Sn doping reduce this bandgap for equal doping concentrations. Bilayers of doped graphene are also studied and it is found that the bandgap of these materials is less than that of the single layer counterparts. Finally, a transverse electric field is applied to the doped bilayers and it is found that the bandgap is inversely proportional to the electric field strength in contrast to what has been observed in the case of pristine bilayers. Carrier effective masses were calculated and in general the effective masses of electrons and holes are found to be similar. (C) 2013 AIP Publishing LLC. C1 [Kaplan, D.; Swaminathan, V.] USA, RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA. [Recine, G.] NYU, Polytech Inst, Dept Appl Phys, Brooklyn, NY 11201 USA. [Recine, G.] Fordham Univ, Dept Phys & Engn Phys, Bronx, NY 10458 USA. [Balu, R.; Karna, S.] USA, RDECOM ARL, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Kaplan, D (reprint author), USA, RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA. EM daniel.b.kaplan.civ@mail.mil NR 33 TC 10 Z9 10 U1 2 U2 58 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 14 PY 2013 VL 113 IS 18 AR 183701 DI 10.1063/1.4804060 PG 5 WC Physics, Applied SC Physics GA 149BX UT WOS:000319294100034 ER PT J AU Gut, IM Beske, PH Hubbard, KS Lyman, ME Hamilton, TA McNutt, PM AF Gut, Ian M. Beske, Phillip H. Hubbard, Kyle S. Lyman, Megan E. Hamilton, Tracey A. McNutt, Patrick M. TI Novel Application of Stem Cell-Derived Neurons to Evaluate the Time- and Dose-Dependent Progression of Excitotoxic Injury SO PLOS ONE LA English DT Article ID HIPPOCAMPAL-NEURONS; IN-VITRO; MONOSODIUM GLUTAMATE; MOLECULAR-MECHANISMS; BRAIN LESIONS; DEATH; APOPTOSIS; NECROSIS; CULTURES; DEPOLARIZATION AB Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging from ischemia to neural degeneration. Under conditions of elevated glutamate, the excessive activation of GluRs causes internalization of pathologic levels of Ca2+, culminating in bioenergetic failure, organelle degradation, and cell death. Efforts to characterize cellular and molecular aspects of excitotoxicity and conduct therapeutic screening for pharmacologic inhibitors of excitogenic progression have been hindered by limitations associated with primary neuron culture. To address this, we evaluated glutamate-induced neurotoxicity in highly enriched glutamatergic neurons (ESNs) derived from murine embryonic stem cells. As of 18 days in vitro (DIV 18), ESNs were synaptically coupled, exhibited spontaneous network activity with neurotypic mEPSCs and expressed NMDARs and AMPARs with physiological current: voltage behaviors. Addition of 0.78-200 mu M glutamate evoked reproducible time-and dose-dependent metabolic failure in 6 h, with a calculated EC50 value of 0.44 mu M at 24 h. Using a combination of cell viability assays and electrophysiology, we determined that glutamate-induced toxicity was specifically mediated by NMDARs and could be inhibited by addition of NMDAR antagonists, increased extracellular Mg2+ or substitution of Ba2+ for Ca2+. Glutamate treatment evoked neurite fragmentation and focal swelling by both immunocytochemistry and scanning electron microscopy. Presentation of morphological markers of cell death was dose-dependent, with 0.78-200 mu M glutamate resulting in apoptosis and 3000 mu M glutamate generating a mixture of necrosis and apoptosis. Addition of neuroprotective small molecules reduced glutamate-induced neurotoxicity in a dose-dependent fashion. These data indicate that ESNs replicate many of the excitogenic mechanisms observed in primary neuron culture, offering a moderate-throughput model of excitotoxicity that combines the verisimilitude of primary neurons with the flexibility and scalability of cultured cells. ESNs therefore offer a physiologically relevant platform that exhibits characteristic NMDAR responses, and appears suitable to evaluate molecular mechanisms of glutamate-induced excitotoxicity and screen for candidate therapeutics. C1 [Gut, Ian M.; Beske, Phillip H.; Hubbard, Kyle S.; Lyman, Megan E.; Hamilton, Tracey A.; McNutt, Patrick M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP McNutt, PM (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM patrick.mcnutt@us.army.mil OI McNutt, Patrick/0000-0002-5703-4565 FU National Institutes of Health National Institute of Allergy and Infectious Diseases [AOD12058-0001-0000]; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [CBM.THRTOX.01.10.RC.021] FX This work was funded by the National Institutes of Health National Institute of Allergy and Infectious Diseases (IAA number AOD12058-0001-0000) and the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (grant number CBM.THRTOX.01.10.RC.021). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 9 Z9 9 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 14 PY 2013 VL 8 IS 5 AR e64423 DI 10.1371/journal.pone.0064423 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 146RE UT WOS:000319107400125 PM 23691214 ER PT J AU Amani, M Chin, ML Birdwell, AG O'Regan, TP Najmaei, S Liu, Z Ajayan, PM Lou, J Dubey, M AF Amani, Matin Chin, Matthew L. Birdwell, A. Glen O'Regan, Terrance P. Najmaei, Sina Liu, Zheng Ajayan, Pulickel M. Lou, Jun Dubey, Madan TI Electrical performance of monolayer MoS2 field-effect transistors prepared by chemical vapor deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID ATOMIC LAYERS; MOBILITY AB Molybdenum disulfide (MoS2) field effect transistors (FET) were fabricated on atomically smooth large-area single layers grown by chemical vapor deposition. The layer qualities and physical properties were characterized using high-resolution Raman and photoluminescence spectroscopy, scanning electron microscopy, and atomic force microscopy. Electronic performance of the FET devices was measured using field effect mobility measurements as a function of temperature. The back-gated devices had mobilities of 6.0 cm(2)/V s at 300 K without a high-k dielectric overcoat and increased to 16.1 cm(2)/V s with a high-k dielectric overcoat. In addition the devices show on/off ratios ranging from 10(5) to 10(9). (C) 2013 AIP Publishing LLC. C1 [Amani, Matin; Chin, Matthew L.; Birdwell, A. Glen; O'Regan, Terrance P.; Dubey, Madan] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20723 USA. [Amani, Matin] Oregon State Univ, Dept Elect Engn, Corvallis, OR 97331 USA. [Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RP Dubey, M (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20723 USA. EM madan.dubey.civ@mail.mil RI najmaei, sina/H-8536-2013; Liu, Zheng/C-1813-2014 OI Liu, Zheng/0000-0002-8825-7198 FU Army Research Lab (ARL) Director's Strategic Initiative (DSI) program; ARO MURI FX The authors acknowledge the support of the Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The authors would also like to thank Dr. Pani Varanasi, ARO for his in-depth technical discussion on 2D atomic layer R&D. P.M.A., J.L., S.N, and Z.L. also acknowledge funding support from the ARO MURI program on 2D materials. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the U.S. Government. The U.S. Government is authorized to reproduce or distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 22 TC 81 Z9 81 U1 9 U2 179 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 13 PY 2013 VL 102 IS 19 AR 193107 DI 10.1063/1.4804546 PG 4 WC Physics, Applied SC Physics GA 164WB UT WOS:000320440800086 ER PT J AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. TI The effect of nitric oxide anneals on silicon vacancies at and very near the interface of 4H SiC metal oxide semiconducting field effect transistors using electrically detected magnetic resonance SO APPLIED PHYSICS LETTERS LA English DT Article ID 4H-SIC MOSFETS AB We use three electrically detected magnetic resonance (EDMR) approaches to explore nitric oxide (NO) annealing in 4H SiC metal-oxide-semiconductor field-effect transistors (MOSFETs). One approach is sensitive to defects at the interface and those extending into the SiC. Two of these approaches are particularly sensitive to SiC/SiO2 interface defects. They show that NO anneals decrease the EDMR response. Since this and earlier studies indicate the ubiquitous presence of silicon vacancy centers in SiC MOSFETs, our results provide strong circumstantial evidence that these defects play an important role in limiting device performance and that NO anneals are effective in reducing their populations. (C) 2013 AIP Publishing LLC. C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA. FU US Army Research Laboratory; General Electric under the U.S. Department of Commerce [NIST60NANB10D109] FX The authors would like to thank Daniel Habersat from the US Army Research Lab and Thomas Aichinger from The Pennsylvania State University (now with Infineon Technologies) for their insight. The work has been primarily supported by the US Army Research Laboratory, with additional support from General Electric under the U.S. Department of Commerce under Award No. NIST60NANB10D109. NR 16 TC 10 Z9 10 U1 3 U2 37 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 13 PY 2013 VL 102 IS 19 AR 193507 DI 10.1063/1.4805355 PG 4 WC Physics, Applied SC Physics GA 164WB UT WOS:000320440800104 ER PT J AU Eyase, FL Akala, HM Ingasia, L Cheruiyot, A Omondi, A Okudo, C Juma, D Yeda, R Andagalu, B Wanja, E Kamau, E Schnabel, D Bulimo, W Waters, NC Walsh, DS Johnson, JD AF Eyase, Fredrick L. Akala, Hoseah M. Ingasia, Luiser Cheruiyot, Agnes Omondi, Angela Okudo, Charles Juma, Dennis Yeda, Redemptah Andagalu, Ben Wanja, Elizabeth Kamau, Edwin Schnabel, David Bulimo, Wallace Waters, Norman C. Walsh, Douglas S. Johnson, Jacob D. TI The Role of Pfmdr1 and Pfcrt in Changing Chloroquine, Amodiaquine, Mefloquine and Lumefantrine Susceptibility in Western-Kenya P. falciparum Samples during 2008-2011 SO PLOS ONE LA English DT Article ID RESISTANCE TRANSPORTER GENE; TIME QUANTITATIVE PCR; PLASMODIUM-FALCIPARUM; ARTEMETHER-LUMEFANTRINE; IN-VIVO; SULFADOXINE-PYRIMETHAMINE; MOLECULAR ANALYSIS; MALARIA; ARTEMISININ; ARTESUNATE AB Single Nucleotide Polymorphisms (SNPs) in the Pfmdr1, and Pfcrt, genes of Plasmodium falciparum may confer resistance to a number of anti-malaria drugs. Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (AQ) resistance. mefloquine (MQ) and lumefantrine (LU) sensitivities are linked to Pfmdr1 86Y. Additionally, Pfcrt K76 allele carrying parasites have shown tolerance to LU. We investigated the association between Pfmdr1 86/Pfcrt 7276 and P. falciparum resistance to CQ, AQ, MQ and LU using field samples collected during 2008-2011 from malaria endemic sites in western Kenya. Genomic DNA from these samples was genotyped to examine SNPs and haplotypes in Pfmdr1 and Pfcrt respectively. Additionally, immediate ex vivo and in vitro drug sensitivity profiles were assessed using the malaria SYBR Green I fluorescence-based assay. We observed a rapid but steady percent increase in wild-type parasites with regard to both Pfmdr1 and Pfcrt between 2008 and 2011 (p<0.0001). Equally, a significant reciprocate decrease in AQ and CQ median IC50 values occurred (p<0.0001) during the same period. Thus, the data in this study point to a significantly rapid change in parasite response to AQ and CQ in the study period. This may be due to releasing of drug pressure on the parasite from reduced use of AQ in the face of increased Artemisinin (ART) Combination Therapy (ACT) administration following the intervention of the Global Fund in 2008. LU has been shown to select for 76K genotypes, thus the observed increase in 76K genotypes coupled with significant cross resistance between LU and MQ, may herald emergence of tolerance against both drugs in future. C1 [Eyase, Fredrick L.; Akala, Hoseah M.; Ingasia, Luiser; Cheruiyot, Agnes; Omondi, Angela; Okudo, Charles; Juma, Dennis; Yeda, Redemptah; Andagalu, Ben; Wanja, Elizabeth; Kamau, Edwin; Bulimo, Wallace; Johnson, Jacob D.] USAMRU K, Dept Emerging Infect Dis Global Emerging Infect S, Nairobi, Kenya. [Waters, Norman C.] US Mil Acad, New York, NY USA. [Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Eyase, FL (reprint author), USAMRU K, Dept Emerging Infect Dis Global Emerging Infect S, Nairobi, Kenya. EM fredrickeyase@yahoo.com RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU Armed Forces Health Surveillance Center (AFHSC-GEIS) FX This work was funded by the Armed Forces Health Surveillance Center (AFHSC-GEIS). The funders had no role in study design, data collection and analysis decision to publish, or preparation of the manuscript. NR 45 TC 22 Z9 23 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 13 PY 2013 VL 8 IS 5 AR e64299 DI 10.1371/journal.pone.0064299 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 145RZ UT WOS:000319036100061 PM 23675533 ER PT J AU Ochieng, C Lutomiah, J Makio, A Koka, H Chepkorir, E Yalwala, S Mutisya, J Musila, L Khamadi, S Richardson, J Bast, J Schnabel, D Wurapa, E Sang, R AF Ochieng, Caroline Lutomiah, Joel Makio, Albina Koka, Hellen Chepkorir, Edith Yalwala, Santos Mutisya, James Musila, Lillian Khamadi, Samoel Richardson, Jason Bast, Joshua Schnabel, David Wurapa, Eyako Sang, Rosemary TI Mosquito-borne arbovirus surveillance at selected sites in diverse ecological zones of Kenya; 2007-2012 SO VIROLOGY JOURNAL LA English DT Article DE Arbovirus; Surveillance; Mosquitoes ID VALLEY FEVER VIRUS; WEST-NILE-VIRUS; POLYMERASE CHAIN-REACTION; USUTU-VIRUS; RT-PCR; CHIKUNGUNYA; DISEASES; AUSTRIA; AFRICA AB Background: Increased frequency of arbovirus outbreaks in East Africa necessitated the determination of distribution of risk by entomologic arbovirus surveillance. A systematic vector surveillance programme spanning 5 years and covering 11 sites representing seven of the eight provinces in Kenya and located in diverse ecological zones was carried out. Methods: Mosquitoes were sampled bi-annually during the wet seasons and screened for arboviruses. Mosquitoes were identified to species, pooled by species, collection date and site and screened for arboviruses by isolation in cell culture and/or RT-PCR screening and sequencing. Results: Over 450,000 mosquitoes in 15,890 pools were screened with 83 viruses being detected/isolated that include members of the alphavirus, flavivirus and orthobunyavirus genera many of which are known to be of significant public health importance in the East African region. These include West Nile, Ndumu, Sindbis, Bunyamwera, Pongola and Usutu viruses detected from diverse sites. Ngari virus, which was associated with hemorrhagic fever in northern Kenya in 1997/98 was isolated from a pool of Anopheles funestus sampled from Tana-delta and from Aedes mcintoshi from Garissa. Insect only flaviviruses previously undescribed in Kenya were also isolated in the coastal site of Rabai. A flavivirus most closely related to the Chaoyang virus, a new virus recently identified in China and two isolates closely related to Quang Binh virus previously unreported in Kenya were also detected. Conclusion: Active transmission of arboviruses of public health significance continues in various parts of the country with possible undetermined human impact. Arbovirus activity was highest in the pastoralist dominated semi-arid to arid zones sites of the country where 49% of the viruses were isolated suggesting a role of animals as amplifiers and indicating the need for improved arbovirus disease diagnosis among pastoral communities. C1 [Ochieng, Caroline; Lutomiah, Joel; Makio, Albina; Koka, Hellen; Yalwala, Santos; Mutisya, James; Musila, Lillian; Khamadi, Samoel; Bast, Joshua; Wurapa, Eyako; Sang, Rosemary] US Army Med Res Unit, Div Emerging Infect Dis, Nairobi, Kenya. [Lutomiah, Joel; Khamadi, Samoel; Sang, Rosemary] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya. [Chepkorir, Edith] Int Ctr Insect Physiol & Ecol, Nairobi, Kenya. [Richardson, Jason; Schnabel, David] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Ochieng, C (reprint author), US Army Med Res Unit, Div Emerging Infect Dis, POB 606, Nairobi, Kenya. EM caroline.ochieng@usamru-k.org RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections surveillance and response System (GEIS) of the Armed Forces Health Surveillance Centre (AFHSC) under the United States department of defense (DOD) FX We acknowledge the technical contribution of Dunstone Betti, John Gachoya, Daniel Ngonga, David Oulo, Francis Mulwa and Reuben Lugalia, This work was funded by the Global Emerging Infections surveillance and response System (GEIS) of the Armed Forces Health Surveillance Centre (AFHSC) under the United States department of defense (DOD) and supported by the Director, KEMRI. NR 38 TC 14 Z9 14 U1 6 U2 24 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAY 10 PY 2013 VL 10 AR 140 DI 10.1186/1743-422X-10-140 PG 10 WC Virology SC Virology GA 155WE UT WOS:000319778300001 PM 23663381 ER PT J AU Seibert, M Nieh, S AF Seibert, Michael Nieh, Sen TI Simulation of dual firing of hydrogen-rich reformate and JP-8 surrogate in a swirling combustor SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article DE Hydrogen; Fuel reforming; External combustion; Jet fuel; Dual firing ID NOX REDUCTION; PERFORMANCE; ENGINE AB Flame control, particularly at very lean conditions, is a critical requirement for external combustion power sources such as thermoelectric and thermophotovoltaic generators. The availability of in-situ produced hydrogen from JP-8 fuel reforming presents a potential supply of hydrogen at the application site, such as the battlefield, without adding a second fuel to the logistics system. This research investigates the use of small amounts of hydrogen co-fired with JP-8 for improved energy efficiency, operational flexibility and environmental protection. Numerical simulations were conducted in a 6 kW (thermal) swirling flow combustor under different conditions. The simulations use hydrogen and a single hydrocarbon surrogate for JP-8 with a 4-step reaction mechanism. It also examined the effect of using hydrogen-rich reformate containing hydrogen, carbon monoxide and other gases dual-fired with JP-8. Results showed that at lean conditions, dual firing of hydrogen or reformate with JP-8 provided improved fuel conversion, better flame stability and higher fuel burnout. Dual firing hydrogen-rich reformate and JP-8 led to increased burner capacity, reduced system size and weight requirements. However, dual firing with hydrogen provided little benefit to JP-8 combustion under stoichiometric or fuel rich conditions because they were limited by mixing rather than chemical kinetics. These results indicate that dual firing of hydrogen with JP-8 is a promising method for improving lean flame stability and burner control. This has the potential to enable small scale power applications with specific temperature requirements such as thermoelectric and thermophotovoltaic generators. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved. C1 [Seibert, Michael] USA, Command Power & Integrat Directorate, RDECOM, CERDEC, Aberdeen Proving Ground, MD 21005 USA. [Nieh, Sen] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA. RP Seibert, M (reprint author), USA, Command Power & Integrat Directorate, RDECOM, CERDEC, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA. EM michael.l.seibert.civ@mail.mil OI Seibert, Michael/0000-0001-5902-7935 FU US Army Communications-Electronics Research Development and Engineering Center FX The authors gratefully acknowledge the US Army Communications-Electronics Research Development and Engineering Center's support in the form of an In-House Laboratory Independent Research project that funded much of this work. NR 10 TC 4 Z9 4 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD MAY 10 PY 2013 VL 38 IS 14 BP 5911 EP 5917 DI 10.1016/j.ijhydene.2013.02.072 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 148GM UT WOS:000319232500044 ER PT J AU Cuddy, MF Poda, AR Brantley, LN AF Cuddy, Michael F. Poda, Aimee R. Brantley, Lauren N. TI Determination of Isoelectric Points and the Role of pH for Common Quartz Crystal Microbalance Sensors SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE isoelectric point; IEP; quartz crystal microbalance; QCM; sensor; mucin ID CONTACT-ANGLE TITRATIONS; PORCINE GASTRIC MUCIN; FORCE MEASUREMENTS; DOUBLE-LAYER; SURFACE; OXIDE; ADSORPTION; AGGREGATION; TRANSITION; FILMS AB Isoelectric points (IEPs) were determined by the method of contact angle titration for five common quartz crystal microbalance (QCM) sensors. The isoelectric points range from mildly basic in the case of Al2O3 sensors (IEP = 8.7) to moderately acidic for Au (5.2) and SiO2 (3.9), to acidic for Ag (3.2) and Ti (2.9). In general, the values reported here are indicative of inherent surface oxides. A demonstration of the effect of the surface isoelectric point on the packing efficiency of thin mucin films is provided for gold and silica QCM sensors. It is determined that mucin layers on both substrates achieve a maximum and equal layer density of similar to 3500 kg/m(3) at the corresponding IEP of either QCM sensor. This implies that mucin film packing is dependent upon short-range electrostatic interactions at the sensor surface. C1 [Cuddy, Michael F.; Poda, Aimee R.; Brantley, Lauren N.] USA, Environm Lab, Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cuddy, MF (reprint author), USA, Environm Lab, Corps Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Michael.Cuddy@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 29 TC 12 Z9 12 U1 3 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY 8 PY 2013 VL 5 IS 9 BP 3514 EP 3518 DI 10.1021/am400909g PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 143AQ UT WOS:000318839100005 PM 23611583 ER PT J AU Bates, ME Keisler, JM Jones, E Linkov, I AF Bates, Matthew E. Keisler, Jeffrey M. Jones, Elizabeth Linkov, Igor TI Risky Removal: Developing a Holistic Understanding of the Risks of Redeveloping Sites Contaminated with Unexploded Ordnance SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Bates, Matthew E.; Linkov, Igor] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Boston, MA 02125 USA. [Jones, Elizabeth] Univ Calif Berkeley, Berkeley, CA 94720 USA. RP Linkov, I (reprint author), 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil NR 4 TC 0 Z9 0 U1 0 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 7 PY 2013 VL 47 IS 9 BP 3955 EP 3956 DI 10.1021/es401369s PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 141WA UT WOS:000318756000004 PM 23607512 ER PT J AU Giri, AK Hirsh, G Duncan, KJ Karna, SP Dennis, CL AF Giri, Anit K. Hirsh, Gary Duncan, Kate J. Karna, Shashi P. Dennis, C. L. TI Magnetic distributions of iron-(nickel zinc ferrite) nanocomposites from first order reversal curve analysis SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID NI-ZN FERRITE; NANOPARTICLES; METAL; NUCLEATION; POLYOLS; GROWTH AB First order reversal curve measurements offer a powerful approach to quantify the magnetic property distributions in materials. Here, we have used this approach to quantify magnetic property distributions and understand the nano-scale mechanisms contributing to the magnetic anisotropy of Fe-(Ni0.5Zn0.5)Fe2O4 nanocomposites. The Fe-(Ni0.5Zn0.5)Fe2O4 nanocomposite powders were synthesized using a chemical method involving ferrite precipitation and controlled reduction which resulted in the formation of iron nanoclusters within the ferrite. Two samples with a similar to 65% and similar to 6% iron composition, respectively, were studied. Transmission electron microscopy measurements yielded an average particle size of similar to 15nm (similar to 65% Fe) and similar to 60nm (similar to 6% Fe). The magnetizations at 7 T for the synthesized nanocomposites (M-7T = 58 Am-2 kg(-1) for the similar to 65% Fe sample and 55 Am-2 kg(-1) for the similar to 6% Fe sample) are close to that of the bulk saturation magnetization (similar to 60 Am-2 kg(-1)) of (Ni0.5Zn0.5)Fe2O4. This is not typical in these ferrite systems, due to poor crystallinity. In our samples, the observed large M-7T may result from the presence of the iron nanoclusters, as well as improved crystallinity. However, there is a slope to the magnetization at high fields which has typically been attributed to surface spin canting. This may instead be an indication of reduced crystallinity at the surface of the nanoparticles, especially in the similar to 65% Fe sample. Furthermore, a difference in interactions between the ferrite and the iron nanoclusters in the two samples results in different anisotropy distributions, as evidenced by a broad transition to saturation for the first sample, and a much sharper transition for the second sample, and confirmed through first order reversal curve measurements. C1 [Giri, Anit K.; Hirsh, Gary; Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Duncan, Kate J.] Communicat Elect Res, Ctr Dev & Engn, Space & Terr Communicat Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dennis, C. L.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. RP Giri, AK (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM anit.giri.ctr@mail.mil NR 17 TC 3 Z9 3 U1 1 U2 28 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2013 VL 113 IS 17 AR 173908 DI 10.1063/1.4803545 PG 5 WC Physics, Applied SC Physics GA 149BK UT WOS:000319292800363 ER PT J AU Giri, AK Paterson, BA McLeod, MV Dennis, CL Majumdar, BS Cho, KC Shull, RD AF Giri, Anit K. Paterson, Brigitte A. McLeod, Michael V. Dennis, Cindi L. Majumdar, Bhaskar S. Cho, Kyu C. Shull, Robert D. TI Effect of crystallographic alignment on the magnetocaloric effect in alloys near the Ni2MnGa stoichiometry SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 12th Joint MMM-Intermag Conference CY JAN 14-18, 2013 CL Chicago, IL SP AIP Publishing, IEEE Magnet Soc ID NI-MN-GA; FIELD-INDUCED STRAIN; SHAPE-MEMORY AB Prior to the development of commercial applications of magnetic refrigerator technology, a large magnetocaloric effect (MCE) in polycrystalline materials must be realized for relatively low magnetic field changes. To increase the MCE, a crystallographic alignment technique, consisting of thermal cycling about the martensite phase transition temperature under a compressive stress, was applied to Heusler alloys with nominal composition Ni2+xMn1-xGa (x = 0.14, 0.16). Magnetic measurements prior to grain alignment show that the maximum entropy changes of -16 J kg(-1) K-1 and -24 J kg(-1) K-1 for samples with x = 0.14 and 0.16, respectively, occurred for a magnetic field change of 7 T. After grain alignment, there was a 56%-79% enhancement of the maximum magnetic entropy change for the same magnetic field change of 7 T. This suggests that thermal cycling under compressive stress may either increase grain alignment (e. g., texture) along the magnetic easy (001) axis, and/or enhance the ease with which a magnetic field is later able to grow favorably oriented twin variants that manifests as an increase of magnetization of the material. Therefore, such an alignment technique may be utilized to enhance the MCE of similar Heusler alloys. C1 [Giri, Anit K.; Cho, Kyu C.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Paterson, Brigitte A.; Dennis, Cindi L.; Shull, Robert D.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. [McLeod, Michael V.; Majumdar, Bhaskar S.] New Mexico Inst Min & Technol, Dept Mat & Met Engn, Socorro, NM 87801 USA. RP Giri, AK (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM anit.giri.ctr@mail.mil NR 11 TC 6 Z9 6 U1 2 U2 26 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2013 VL 113 IS 17 AR 17A907 DI 10.1063/1.4793608 PG 3 WC Physics, Applied SC Physics GA 149BK UT WOS:000319292800052 ER PT J AU Memisevic, V Wallqvist, A Reifman, J AF Memisevic, Vesna Wallqvist, Anders Reifman, Jaques TI Reconstituting protein interaction networks using parameter-dependent domain-domain interactions SO BMC BIOINFORMATICS LA English DT Article DE Merging domain annotations; Domain-domain interactions; Protein-protein interaction networks ID SACCHAROMYCES-CEREVISIAE; GENOME SEQUENCES; DATABASE; PREDICTION; FAMILIES; IDENTIFICATION; FRAMEWORK; RESOURCE; INTERPRO; SMART AB Background: We can describe protein-protein interactions (PPIs) as sets of distinct domain-domain interactions (DDIs) that mediate the physical interactions between proteins. Experimental data confirm that DDIs are more consistent than their corresponding PPIs, lending support to the notion that analyses of DDIs may improve our understanding of PPIs and lead to further insights into cellular function, disease, and evolution. However, currently available experimental DDI data cover only a small fraction of all existing PPIs and, in the absence of structural data, determining which particular DDI mediates any given PPI is a challenge. Results: We present two contributions to the field of domain interaction analysis. First, we introduce a novel computational strategy to merge domain annotation data from multiple databases. We show that when we merged yeast domain annotations from six annotation databases we increased the average number of domains per protein from 1.05 to 2.44, bringing it closer to the estimated average value of 3. Second, we introduce a novel computational method, parameter-dependent DDI selection (PADDS), which, given a set of PPIs, extracts a small set of domain pairs that can reconstruct the original set of protein interactions, while attempting to minimize false positives. Based on a set of PPIs from multiple organisms, our method extracted 27% more experimentally detected DDIs than existing computational approaches. Conclusions: We have provided a method to merge domain annotation data from multiple sources, ensuring large and consistent domain annotation for any given organism. Moreover, we provided a method to extract a small set of DDIs from the underlying set of PPIs and we showed that, in contrast to existing approaches, our method was not biased towards DDIs with low or high occurrence counts. Finally, we used these two methods to highlight the influence of the underlying annotation density on the characteristics of extracted DDIs. Although increased annotations greatly expanded the possible DDIs, the lack of knowledge of the true biological false positive interactions still prevents an unambiguous assignment of domain interactions responsible for all protein network interactions. Executable files and examples are given at: http://www.bhsai.org/downloads/padds/ C1 [Memisevic, Vesna; Wallqvist, Anders; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Appl Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Appl Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, U.S. Army's Network Science Initiative FX The authors were supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or the U. S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 47 TC 8 Z9 8 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD MAY 7 PY 2013 VL 14 AR 154 DI 10.1186/1471-2105-14-154 PG 15 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 147XZ UT WOS:000319206100001 PM 23651452 ER PT J AU Chaccour, CJ Kobylinski, KC Bassat, Q Bousema, T Drakeley, C Alonso, P Foy, BD AF Chaccour, Carlos J. Kobylinski, Kevin C. Bassat, Quique Bousema, Teun Drakeley, Chris Alonso, Pedro Foy, Brian D. TI Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination SO MALARIA JOURNAL LA English DT Article DE Malaria elimination; Ivermectin; Endectocides; Vector control ID ANOPHELES-GAMBIAE; MASS TREATMENT; PLASMODIUM-FALCIPARUM; ARTEMISININ RESISTANCE; ONCHOCERCA-VOLVULUS; PREGNANCY; MOSQUITOS; VECTOR; BLOOD; QUADRIMACULATUS AB Background: The heterogeneity of malaria transmission makes widespread elimination a difficult goal to achieve. Most of the current vector control measures insufficiently target outdoor transmission. Also, insecticide resistance threatens to diminish the efficacy of the most prevalent measures, indoor residual spray and insecticide treated nets. Innovative approaches are needed. The use of endectocides, such as ivermectin, could be an important new addition to the toolbox of anti-malarial measures. Ivermectin effectively targets outdoor transmission, has a novel mechanism of action that could circumvent resistance and might be distributed over the channels already in place for the control of onchocerciasis and lymphatic filariasis. Methods: The previous works involving ivermectin and Anopheles vectors are reviewed and summarized. A review of ivermectin's safety profile is also provided. Finally three definitive clinical trials are described in detail and proposed as the evidence needed for implementation. Several smaller and specific supportive studies are also proposed. Conclusions: The use of ivermectin solves many challenges identified for future vector control strategies. It is an effective and safe endectocide that was approved for human use more than 25 years ago. Recent studies suggest it might become an effective and complementary strategy in malaria elimination and eradication efforts; however, intensive research will be needed to make this a reality. C1 [Chaccour, Carlos J.] Univ Navarra Clin, Dept Internal Med, Pamplona 31008, Spain. [Chaccour, Carlos J.] Univ Navarra, Inst Salud Trop, E-31080 Pamplona, Spain. [Kobylinski, Kevin C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Bassat, Quique; Alonso, Pedro] Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, Barcelona, Spain. [Bassat, Quique; Alonso, Pedro] CISM, Maputo, Mozambique. [Bousema, Teun; Drakeley, Chris] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1, England. [Bousema, Teun] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands. [Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. RP Chaccour, CJ (reprint author), Univ Navarra Clin, Dept Internal Med, Av Pio 12 36, Pamplona 31008, Spain. EM cchaccour@unav.es; Brian.Foy@ColoState.EDU RI Bousema, Teun/N-3574-2014; Bassat, Quique/P-2341-2016; Foy, Brian/E-6230-2017 OI Bassat, Quique/0000-0003-0875-7596; Foy, Brian/0000-0002-9117-203X FU US National Institutes of Health-National Institute of Allergy and Infectious Diseases [1R01AI094349-01A1] FX BDF was supported by grant 1R01AI094349-01A1 from the US National Institutes of Health-National Institute of Allergy and Infectious Diseases. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the US Department of the Army or the Department of Defense. We thank Juliane Chaccour for proofreading the manuscript. NR 62 TC 34 Z9 34 U1 3 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 7 PY 2013 VL 12 AR 153 DI 10.1186/1475-2875-12-153 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 147SO UT WOS:000319187500001 PM 23647969 ER PT J AU Kirste, R Mita, S Hussey, L Hoffmann, MP Guo, W Bryan, I Bryan, Z Tweedie, J Xie, JQ Gerhold, M Collazo, R Sitar, Z AF Kirste, Ronny Mita, Seiji Hussey, Lindsay Hoffmann, Marc P. Guo, Wei Bryan, Isaac Bryan, Zachary Tweedie, James Xie, Jinqiao Gerhold, Michael Collazo, Ramon Sitar, Zlatko TI Polarity control and growth of lateral polarity structures in AlN SO APPLIED PHYSICS LETTERS LA English DT Article ID INVERSION DOMAINS; SAPPHIRE; GAN; EPILAYERS AB The control of the polarity of metalorganic chemical vapor deposition grown AlN on sapphire is demonstrated. Al-polar and N-polar AlN is grown side-by-side yielding a lateral polarity structure. Scanning electron microscopy measurements reveal a smooth surface for the Al-polar and a relatively rough surface for the N-polar AlN domains. Transmission electron microscopy shows mixed edge-screw type dislocations with polarity-dependent dislocation bending. Raman spectroscopy reveals compressively strained Al-polar and relaxed N-polar domains. The near band edge luminescence consists of free and bound excitons which are broadened for the Al-polar AlN. Relaxation, better optical quality, and dislocation bending in the N-polar domains are explained by the columnar growth mode. (C) 2013 AIP Publishing LLC. C1 [Kirste, Ronny; Hussey, Lindsay; Hoffmann, Marc P.; Guo, Wei; Bryan, Isaac; Bryan, Zachary; Tweedie, James; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mita, Seiji; Xie, Jinqiao] HexaTech Inc, Morrisville, NC 27560 USA. [Gerhold, Michael] USA, Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Kirste, R (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. FU Army Research Laboratory [W911NF-04-D-0003]; William Clark program monitor; NSF [DMR-1108071] FX This work was supported in part by the Army Research Laboratory (Contract No. W911NF-04-D-0003), William Clark program monitor, and NSF under Contract No. DMR-1108071. We thank Professor Axel Hoffmann of TU Berlin for the support in the Raman spectroscopy measurements. NR 25 TC 22 Z9 22 U1 6 U2 61 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 6 PY 2013 VL 102 IS 18 AR 181913 DI 10.1063/1.4804575 PG 4 WC Physics, Applied SC Physics GA 164VV UT WOS:000320439900035 ER PT J AU Borodin, O Behl, W Jow, TR AF Borodin, Oleg Behl, Wishvender Jow, T. Richard TI Oxidative Stability and Initial Decomposition Reactions of Carbonate, Sulfone, and Alkyl Phosphate-Based Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID LI-ION BATTERIES; DENSITY-FUNCTIONAL THEORY; MOLECULAR-DYNAMICS SIMULATION; ELECTROCHEMICAL PROPERTIES; ANODIC STABILITY; AIR BATTERIES; LIQUID ELECTROLYTES; PROPYLENE CARBONATE; LITHIUM BATTERIES; REDOX SHUTTLES AB The oxidative stability and initial oxidation-induced decomposition reactions of common electrolyte solvents for batteries and electrical double layer capacitors were investigated using quantum chemistry (QC) calculations. The investigated electrolytes consisted of linear (DMC, EMC) and cyclic carbonate (EC, PC, VC), sulfone (TMS), sulfonate, and alkyl phosphate solvents paired with BF4-, PF6-, bis-(fluorosulfonyl)imide (FSI-), difluoro-(oxalato)borate (DFOB-), dicyanotriazolate.(DCTA(-)), and B(CN)(4)(-) anions. Most QC calculations were performed using the MOS-.2X, LC-omega PBE. density functional and compared with the G4MP2 results where feasible. The calculated oxidation potentials were compared with previous and new experimental data The intrinsic oxidation potential of most solvent molecules was found to be higher than experimental values for electrolytes even after the solvation contribution was included in the QC calculations via a polarized continuum model The presence of BF4-, PF6-, B(CN)(4)(-); and FSI- anions near the solvents was found to significantly decrease the oxidative stability of Many solvents due to the spontaneous or low barrier (for FSI-) H- and F-abstraction reaction that followed the initial electron removal step; Such Spontaneous H-abstraction reactions were not observed for the solvent complexes with DCTA(-) or DFOB- anions or for VC/anion, TMP/PF6- complexes Spontaneous H-transfer reactions were also found for dimers of the oxidized carbonates (EC, DMC), alkyl phosphates. (TMP), while low bather H-transfer was found for (timers of sulfones (TMS and EMS). These reactions resulted in a significant decrease of the dimer oxidation potential compared to the oxidation potential of the isolated solvent molecules. The presence of anions or an explicitly included solvent molecule next to the oxidized solvent molecules also reduced the barriers for the oxidation-induced decomposition reaction and often changed the decomposition products. When a Li+ cation polarized the solvent in the ECn/LiBF4 and ECn/LiPF6 complexes, the complex oxidation potential was 0.3-0.6. eV higher than the oxidation potential of ECn/BF4-. and ECn/PF6-. C1 [Borodin, Oleg; Behl, Wishvender; Jow, T. Richard] USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Borodin, O (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. Department of Energy [DE-IA01-11EE003413]; U.S. Army Research Laboratory [DE-IA01-11EE003413] FX This work was supported via an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory under DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs, including the ARB and BATT Programs. Computational resources from the DoD's High Performance Computing Modernization Program (HPCMP) are acknowledged. NR 60 TC 56 Z9 57 U1 8 U2 119 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 EI 1932-7455 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAY 2 PY 2013 VL 117 IS 17 BP 8661 EP 8682 DI 10.1021/jp400527c PG 22 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 138UX UT WOS:000318536600010 ER PT J AU He, QG Li, Q Khene, S Ren, XM Lopez-Suarez, FE Lozano-Castello, D Bueno-Lopez, A Wu, G AF He, Qinggang Li, Qing Khene, Samson Ren, Xiaoming Lopez-Suarez, Franz E. Lozano-Castello, Dolores Bueno-Lopez, Agustin Wu, Gang TI High-Loading Cobalt Oxide Coupled with Nitrogen-Doped Graphene for Oxygen Reduction in Anion-Exchange-Membrane Alkaline Fuel Cells SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID TRANSITION-METAL CHALCOGENIDES; ONION-LIKE CARBON; ELECTROCHEMICAL REDUCTION; METHANOL ELECTROOXIDATION; HEAT-TREATMENT; O-2 REDUCTION; CATALYSTS; ELECTROCATALYSTS; PERFORMANCE; NANOPARTICLES AB A new nanocomposite catalyst consisting of high loading cobalt oxide (CoO) on nitrogen doped reduced graphene oxide (rGO) for oxygen reduction reaction (ORR) was prepared in this work Its high activity for the ORR in alkaline electrolyte was determined using the rotating disk electrode technique, and further confirmed in real alkaline membrane fuel cells. A combination of physicochemical characterization (e.g., X-ray absorption and X-ray photoelectron spectra) and density functional theory (DFT) calculation suggests that cobalt(II) cations in the composite catalyst may coordinate with the pyridinic nitrogen atoms doped into graphene planes, most likely the active species for the ORR Especially, the DFT calculations indicate that a stable rGO(N)-Co(II)-O-Co(II)-rGO(N) structure can be formed in the nitrogen-doped graphene catalist. Kinetic parameter analysis shows a high selectivity of four electron reduction on the composite catalyst during the ORR with an average electron transfer number of 3.75. A synergistic effect between the rGO(N) and CoO may exist, yielding a much higher catalytic activity on the CoO/rGO(N) catalyst, compared to either rGO(N) or CoO controls. The novel synthesis procedure utilizing rGO(N) to further couple Co(II) yields a high loading of Co species (24.7 wt %). Thus, a relatively thinner cathode in fuel cell can accommodate more active Co species and facilitate O-2 transfer. Due to the high intrinsic activity and efficient mass transport, the CoO-rGO(N) ORR catalyst achieved approaching performance to state-of-the-art Pt/C cathodes in anion-exchange-membrane alkaline fuel cells. C1 [He, Qinggang] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA. [Li, Qing; Wu, Gang] Los Alamos Natl Lab, Mat Phys & Applicat Div, Los Alamos, NM 87545 USA. [Khene, Samson] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa. [Ren, Xiaoming] USA, Res Lab, Adelphi, MD 20783 USA. [Lopez-Suarez, Franz E.; Lozano-Castello, Dolores; Bueno-Lopez, Agustin] Univ Alicante, Dept Inorgan Chem, E-03080 Alicante, Spain. RP He, QG (reprint author), Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA. EM QHe@mednet.ucla.edu; wugang@lanl.gov RI Wu, Gang/E-8536-2010; Li, Qing/G-4502-2011; ren, xiaoming/F-3953-2011; He, Qinggang/O-7639-2014; OI Wu, Gang/0000-0003-4956-5208; Li, Qing/0000-0003-4807-030X; He, Qinggang/0000-0002-7693-8017; Lopez-Suarez, Franz E/0000-0003-2670-7509; Bueno Lopez, Agustin/0000-0002-5434-6459 FU Los Alamos National Laboratory Early Career Laboratory-Directed Research and Development (LDRD) Program FX We would like to thank B. Shyam and F. McLarnon for helpful comments and suggestions during preparation of this manuscript. The financial support from the Los Alamos National Laboratory Early Career Laboratory-Directed Research and Development (LDRD) Program for this work is gratefully acknowledged. NR 69 TC 91 Z9 91 U1 15 U2 298 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAY 2 PY 2013 VL 117 IS 17 BP 8697 EP 8707 DI 10.1021/jp401814f PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 138UX UT WOS:000318536600013 ER PT J AU Johnson, BD van Helmond, N Curry, TB Convertino, VA Joyner, MJ AF Johnson, Blair D. van Helmond, Noud Curry, Timothy B. Convertino, Victor A. Joyner, Michael J. TI Relationship Of Central Venous Pressure To Hemodynamic Responses During Lower Body Negative Pressure And Hemorrhage SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA. [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 216 BP 39 EP 39 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469700118 ER PT J AU DeGroot, D Kenefick, RW Sawka, MN AF DeGroot, David Kenefick, Robert W. Sawka, Michael N. TI Extremity Cooling Reduces Exertional Heat Injury Severity During Military Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [DeGroot, David] US Army Publ Hlth Command, Aderbeen, MD USA. [Kenefick, Robert W.; Sawka, Michael N.] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 298 BP 65 EP 65 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469700200 ER PT J AU Cuddy, J Buller, M Hailes, W Ruby, B AF Cuddy, John Buller, Mark Hailes, Walter Ruby, Brent TI Skin Temperature And Heart Rate Estimate Physiological Strain During Exercise In The Heat SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Cuddy, John; Hailes, Walter; Ruby, Brent] Univ Montana, Missoula, MT 59812 USA. [Buller, Mark] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1000 BP 215 EP 215 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469701352 ER PT J AU Cameron, KL Campbell, SE Peck, KY Westrick, RB Owens, BD AF Cameron, Kenneth L. Campbell, Scot E. Peck, Karen Y. Westrick, Richard B. Owens, Brett D. TI Extreme Glenoid Retroversion is Associated with Increased Rotator Cuff Strength in the Shoulder SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Cameron, Kenneth L.; Campbell, Scot E.; Peck, Karen Y.; Westrick, Richard B.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1092 BP 240 EP 241 PG 2 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469702042 ER PT J AU Asplund, C AF Asplund, Chad TI Exercise Related Syncope In Active Duty Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Asplund, Chad] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1124 BP 250 EP 250 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469702074 ER PT J AU Sauer, SG Fellin, RE Frykman, PN Seay, JF AF Sauer, Shane G. Fellin, Rebecca E. Frykman, Peter N. Seay, Joseph F. TI Knee Moments Do Not Increase Proportionally To The Load Carried While Walking SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Sauer, Shane G.; Fellin, Rebecca E.; Frykman, Peter N.; Seay, Joseph F.] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1371 BP 309 EP 309 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469702275 ER PT J AU Simpson, K Hendrickson, NR Redmond, JE Cohen, BS Spiering, BA Knapik, JJ Sharp, MA AF Simpson, Kathleen Hendrickson, Nathan R. Redmond, Jan E. Cohen, Bruce S. Spiering, Barry A. Knapik, Joseph J. Sharp, Marilyn A. TI Intensity of Physical Activity Performed During US Army Basic Combat Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Simpson, Kathleen; Hendrickson, Nathan R.; Redmond, Jan E.; Cohen, Bruce S.; Spiering, Barry A.; Sharp, Marilyn A.] US Army Res Inst Environm Med, Natick, MA USA. [Knapik, Joseph J.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1426 BP 325 EP 325 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469702320 ER PT J AU Delasobera, BE Shelley, N Robinson, S Ho, G Howard, T AF Delasobera, Bronson Elizabeth Shelley, Neal Robinson, Scott Ho, Garry Howard, Thomas TI Platelet Rich Plasma: Improvement in Pain by Anatomical Site and Number of Injections SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Delasobera, Bronson Elizabeth; Shelley, Neal] Georgetown Univ, Washington, DC USA. [Robinson, Scott] US Army, Lacey, WA USA. [Ho, Garry; Howard, Thomas] Virginia Commonwealth Univ, Fairfax, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1506 BP 349 EP 349 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469702400 ER PT J AU Cosio-Lima, LM Brown, K Reynolds, K Perry, RA AF Cosio-Lima, Ludmila M. Brown, Kathleen Reynolds, Katy Perry, Ricky A. TI Physical Training-Related Injuries And Illnesses In A Sergeants Major Academy Class SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Cosio-Lima, Ludmila M.; Reynolds, Katy; Perry, Ricky A.] Univ W Florida, Pensacola, FL 32514 USA. [Brown, Kathleen] US ARMY, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1718 BP 393 EP 393 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703134 ER PT J AU Hibberd, EE Shutt, CE Oyama, S Blackburn, JT Myers, JB AF Hibberd, Elizabeth E. Shutt, Casey E. Oyama, Sakiko Blackburn, J. Troy Myers, Joseph B. TI Physical Contributors to Glenohumeral Internal Rotation Deficit in High School Baseball Players SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Hibberd, Elizabeth E.; Blackburn, J. Troy; Myers, Joseph B.] Univ N Carolina, Chapel Hill, NC USA. [Shutt, Casey E.] US Army Baylor Univ, San Antonio, TX USA. [Oyama, Sakiko] Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1722 BP 394 EP 394 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703138 ER PT J AU Bushman, TT Grier, T Chervak, M Anderson, M Jones, B AF Bushman, Timothy T. Grier, Tyson Chervak, Michelle Anderson, Morgan Jones, Bruce TI Association of Physical Fitness Assessments and Injury Risk among US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Bushman, Timothy T.; Grier, Tyson; Chervak, Michelle; Anderson, Morgan; Jones, Bruce] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1728 BP 396 EP 396 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703143 ER PT J AU Warr, BJ Fellin, RE Frykman, PN Sauer, SG Goss, DL Seay, JJ AF Warr, Bradley J. Fellin, Rebecca E. Frykman, Peter N. Sauer, Shane G. Goss, Donald L. Seay, Joseph J. TI No Differences in Self-reported Injuries or Performance Between Characterized Foot-strike Patterns Amongst US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Warr, Bradley J.; Fellin, Rebecca E.; Frykman, Peter N.; Sauer, Shane G.; Seay, Joseph J.] US Army, Environm Med Res Inst, Natick, MA USA. [Goss, Donald L.] Baylor Univ, US Army, Phys Therapy Program, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1734 BP 398 EP 398 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703148 ER PT J AU Asplund, C AF Asplund, Chad TI Exercise Related Syncope In Active Duty Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Asplund, Chad] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1820 BP 422 EP 422 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703213 ER PT J AU Fellin, RE Seay, JF Hill, RD Saldana, S Cannon, DW DeVita, P Ip, EH Martin, DF Messier, SP AF Fellin, Rebecca E. Seay, Joseph F. Hill, Ryan D. Saldana, Santiago Cannon, D. Wayne DeVita, Paul Ip, Edward H. Martin, David F. Messier, Stephen P. TI Differences in Running Mechanics and Strength between Runners in Minimalist and Traditional Footwear SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Fellin, Rebecca E.; Seay, Joseph F.] US Army Res Inst Environm Med, Natick, MA USA. [Hill, Ryan D.; Messier, Stephen P.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Saldana, Santiago; Ip, Edward H.; Martin, David F.] Wake Forest Sch Med, Winston Salem, NC USA. [Cannon, D. Wayne] Wayne Cannon Phys Therapy & Associates, Winston Salem, NC USA. [DeVita, Paul] E Carolina Univ, Greenville, NC USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1873 BP 424 EP 424 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703217 ER PT J AU Mayhew, JL Schumacher, RM Mann, B Brechue, WF Clasey, JL Piper, FC AF Mayhew, Jerry L. Schumacher, Richard M. Mann, Bryan Brechue, William F. Clasey, Jody L. Piper, Fontaine C. TI Comparison Of Techniques For Estimating DXA %fat In NCAA Division II Male Athletes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Mayhew, Jerry L.; Schumacher, Richard M.; Piper, Fontaine C.] Truman State Univ, Kirksville, MO USA. [Mann, Bryan] Univ Missouri, Columbia, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Clasey, Jody L.] Univ Kentucky, Lexington, KY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1950 BP 447 EP 447 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703281 ER PT J AU Schumacher, RM Mayhew, JL Piper, FC Mann, B Brechue, WF Clasey, JL Smith-Ryan, AE AF Schumacher, Richard M. Mayhew, Jerry L. Piper, Fontaine C. Mann, Bryan Brechue, William F. Clasey, Jody L. Smith-Ryan, Abbie E. TI Validation of BIA and Skinfold Prediction Equations to Estimate Body Composition in College Football Players SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Schumacher, Richard M.; Mayhew, Jerry L.; Piper, Fontaine C.] Truman State Univ, Kirksville, MO USA. [Mann, Bryan] Univ Missouri, Columbia, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Clasey, Jody L.] Univ Kentucky, Lexington, KY USA. [Smith-Ryan, Abbie E.] Univ N Carolina, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 1949 BP 447 EP 447 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469703280 ER PT J AU Kobermann, AM Galloway, WC Allen, WM Mayhew, JL Leahy, GD Crowder, TA AF Kobermann, Andrea M. Galloway, Warren C. Allen, Wesley M. Mayhew, Jerry L. Leahy, Guy D. Crowder, Todd A. TI Relationship of Body Composition Measurement Techniques with Physical Fitness Tests in College ROTC Cadets SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Kobermann, Andrea M.; Galloway, Warren C.; Allen, Wesley M.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Leahy, Guy D.] Davis Monthan Air Force Base, Tucson, AZ USA. [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2448 BP 579 EP 579 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469704340 ER PT J AU Crowder, TA Ferrara, AL Levinbook, MD AF Crowder, Todd A. Ferrara, Andrew L. Levinbook, Max D. TI Comparing the APFT and a Military Optimal Performance Challenge Related to Body Mass and Potential Military Readiness SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. [Ferrara, Andrew L.; Levinbook, Max D.] US Army, Schofield Barracks, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2454 BP 580 EP 581 PG 2 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469704346 ER PT J AU Leahy, GD Crowder, TA Mayhew, JL AF Leahy, Guy D. Crowder, Todd A. Mayhew, Jerry L. TI Comparison of Fitness Performance Tests between Air Force Active Duty and National Guard Men between 18 and 59 Years Old SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Leahy, Guy D.] Davis Monthan Air Force Base, Tucson, AZ USA. [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. [Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Kirksville, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2451 BP 580 EP 580 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469704343 ER PT J AU Clark, NJ Mayhew, JL Reneau, P Brechue, WF AF Clark, Nicole J. Mayhew, Jerry L. Reneau, Paul Brechue, William F. TI Effect Of Free-Weight And Machine-Weight Training On Upper-Body Strength in Low- And High-Strength College Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Clark, Nicole J.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Reneau, Paul] Fairmont State Univ, Fairmont, WV USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2488 BP 591 EP 591 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469704380 ER PT J AU Reneau, P Ryan, M Brechue, WF Pujol, TJ Mann, JB Mayhew, J AF Reneau, Paul Ryan, Michael Brechue, William F. Pujol, Thomas J. Mann, J. B. Mayhew, Jerry TI Accuracy Of 1RM Bench Press Prediction Equations In Untrained, Trained, And Athletic College-age Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Reneau, Paul; Ryan, Michael] Fairmont State Univ, Fairmont, WV USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. [Mann, J. B.] Univ Missouri, Columbia, MO USA. [Mayhew, Jerry] Truman State Univ, Kirksville, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2535 BP 604 EP 605 PG 2 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469704427 ER PT J AU Wilken, JM Shaffer, SW Patzkowski, JC Blanck, RV Owens, JG Hsu, JR AF Wilken, Jason M. Shaffer, Scott W. Patzkowski, Jeanne C. Blanck, Ryan V. Owens, Johnny G. Hsu, Joseph R. TI Activity Limitations Following Severe Extremity Trauma in Military Service Members SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Wilken, Jason M.; Blanck, Ryan V.; Owens, Johnny G.] Ctr Intrepid, Ft Sam Houston, TX USA. [Shaffer, Scott W.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Patzkowski, Jeanne C.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hsu, Joseph R.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2556 BP 611 EP 611 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469705007 ER PT J AU DiPasquale, DM Strangman, GE Muza, SR AF DiPasquale, Dana M. Strangman, Gary E. Muza, Stephen R. TI Altitude Vs. Hypoxia: Comparing The Effects Of Exercise In Hypobaric And Normobaric Hypoxia On Resting Heart Rate SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [DiPasquale, Dana M.; Strangman, Gary E.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cambridge, MA 02138 USA. [Muza, Stephen R.] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2706 BP 632 EP 632 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469705068 ER PT J AU Coffey, L Roy, T Lopez, H AF Coffey, Laurel Roy, Tanja Lopez, Heather TI Physical Demands and Low Back Pain in Deployed Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 60th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-JUN 01, 2013 CL Indianapolis, IN SP Amer Coll Sports Med C1 [Coffey, Laurel; Roy, Tanja] USARIEM, Natick, MA USA. [Lopez, Heather] US Army, Ft Campbell, KY USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2013 VL 45 IS 5 SU 1 MA 2749 BP 646 EP 646 PG 1 WC Sport Sciences SC Sport Sciences GA 300ND UT WOS:000330469705111 ER PT J AU Twenhafel, NA Mattix, ME Johnson, JC Robinson, CG Pratt, WD Cashman, KA Wahl-Jensen, V Terry, C Olinger, GG Hensley, LE Honko, AN AF Twenhafel, N. A. Mattix, M. E. Johnson, J. C. Robinson, C. G. Pratt, W. D. Cashman, K. A. Wahl-Jensen, V. Terry, C. Olinger, G. G. Hensley, L. E. Honko, A. N. TI Pathology of Experimental Aerosol Zaire Ebolavirus Infection in Rhesus Macaques SO VETERINARY PATHOLOGY LA English DT Article DE aerosol; animal model; ebolavirus; filovirus; macaque; rhesus; Zaire; Zaire ebolavirus ID FIBROBLASTIC RETICULAR CELLS; HEMORRHAGIC-FEVER VIRUSES; AFRICAN-GREEN MONKEYS; NIEMANN-PICK C1; DENDRITIC CELLS; NONHUMAN-PRIMATES; ALVEOLAR MACROPHAGES; CYNOMOLGUS MACAQUES; MARBURG VIRUSES; NITRIC-OXIDE AB There is limited knowledge of the pathogenesis of human ebolavirus infections and no reported human cases acquired by the aerosol route. There is a threat of ebolavirus as an aerosolized biological weapon, and this study evaluated the pathogenesis of aerosol infection in 18 rhesus macaques. Important and unique findings include early infection of the respiratory lymphoid tissues, early fibrin deposition in the splenic white pulp, and perivasculitis and vasculitis in superficial dermal blood vessels of haired skin with rash. Initial infection occurred in the respiratory lymphoid tissues, fibroblastic reticular cells, dendritic cells, alveolar macrophages, and blood monocytes. Virus spread to regional lymph nodes, where significant viral replication occurred. Virus secondarily infected many additional blood monocytes and spread from the respiratory tissues to multiple organs, including the liver and spleen. Viremia, increased temperature, lymphocytopenia, neutrophilia, thrombocytopenia, and increased alanine aminotransferase, aspartate aminotransferase, g-glutamyl transpeptidase, total bilirubin, serum urea nitrogen, creatinine, and hypoalbuminemia were measurable mid to late infection. Infection progressed rapidly with whole-body destruction of lymphoid tissues, hepatic necrosis, vasculitis, hemorrhage, and extravascular fibrin accumulation. Hypothermia and thrombocytopenia were noted in late stages with the development of disseminated intravascular coagulation and shock. This study provides unprecedented insight into pathogenesis of human aerosol Zaire ebolavirus infection and suggests development of a medical countermeasure to aerosol infection will be a great challenge due to massive early infection of respiratory lymphoid tissues. Rhesus macaques may be used as a model of aerosol infection that will allow the development of lifesaving medical countermeasures under the Food and Drug Administration's animal rule. C1 [Twenhafel, N. A.; Mattix, M. E.; Johnson, J. C.; Robinson, C. G.; Pratt, W. D.; Cashman, K. A.; Terry, C.; Olinger, G. G.; Hensley, L. E.; Honko, A. N.] USAMRIID, Ft Detrick, MD USA. [Wahl-Jensen, V.] NIAID, Integrated Res Facil Frederick, NIH, Frederick, MD USA. RP Twenhafel, NA (reprint author), US Army, Med Res Inst Infect Dis, Div Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM nancy.twenhafel@us.army.mil OI Olinger, Gene/0000-0001-7338-0292; Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X NR 82 TC 30 Z9 31 U1 0 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD MAY PY 2013 VL 50 IS 3 BP 514 EP 529 DI 10.1177/0300985812469636 PG 16 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 298BJ UT WOS:000330298600021 PM 23262834 ER PT J AU Agazio, J Hillier, SL Throop, M Goodman, P Padden, D Greiner, S Turner, A AF Agazio, Janice Hillier, Shannon L. Throop, Meryia Goodman, Petra Padden, Diane Greiner, Shawna Turner, Annette TI Mothers going to war: The role of nurse practitioners in the care of military mothers and families during deployment SO JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS LA English DT Article DE Military; women; deployment; children; qualitative research; grounded theory ID MENSTRUAL SUPPRESSION AB Purpose: Many military women are being called to separate from their children to go to war. Most previous research has focused upon paternal, rather than, maternal, separation. The purpose of this article is to describe the experience of military mothers and their children during wartime deployments with clinical implications for nurse practitioners (NPs) in military or community settings. Data sources: Using grounded theory methods, 37 active duty and reserve component military women participated in a one-time interview. Included were women who deployed for at least 4 months to Iraq or Afghanistan and had at least one child under the age of 12 during the separation. Conclusions: Military families present unique challenges for NPs. Mother deployments offer opportunities for intervention and anticipatory guidance across the trajectory of the separation. Military women's emotional and physical health must be supported before, during, and following deployment. Implications for practice: NPs are ideally positioned to support military families. During deployment, the NP's focus may shift to care of the children and their caregiver. Before and at reintegration, NPs are in a key position to intervene early for posttraumatic stress and support family readjustment. C1 [Agazio, Janice; Turner, Annette] Catholic Univ Amer, Sch Nursing, Washington, DC 20064 USA. [Hillier, Shannon L.] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Bethesda, MD USA. [Throop, Meryia] Walter Reed Natl Mil Med Ctr, Ctr Nursing Sci & Clin Inquiry, Bethesda, MD USA. [Goodman, Petra] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Padden, Diane; Greiner, Shawna] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Agazio, J (reprint author), Catholic Univ Amer, Sch Nursing, 620 Michigan Ave NE, Washington, DC 20064 USA. EM Agazio@cua.edu FU TriService Nursing Research Program, Uniformed Services University of the Health Sciences FX This research was sponsored by the TriService Nursing Research Program, Uniformed Services University of the Health Sciences; however, the information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, the Department of Defense, or the U. S. Government. NR 10 TC 2 Z9 2 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2327-6886 EI 2327-6924 J9 J AM ASSOC NURSE PRA JI J. Am. Assoc. Nurs. Pract. PD MAY PY 2013 VL 25 IS 5 BP 253 EP 262 DI 10.1111/j.1745-7599.2012.00811.x PG 10 WC Health Care Sciences & Services; Nursing SC Health Care Sciences & Services; Nursing GA 296GM UT WOS:000330173200004 PM 24170567 ER PT J AU Jarvis, SK Wiles, GC Appleton, SN D'Arrigo, RD Lawson, DE AF Jarvis, Stephanie K. Wiles, Gregory C. Appleton, Sarah N. D'Arrigo, Rosanne D. Lawson, Daniel E. TI A Warming-Induced Biome Shift Detected in Tree Growth of Mountain Hemlock [Tsuga mertensiana (Bong.) Carriere] along the Gulf of Alaska SO ARCTIC ANTARCTIC AND ALPINE RESEARCH LA English DT Article ID GLACIER BAY; SOUTHEAST ALASKA; YELLOW-CEDAR; VARIABILITY; HISTORY; FORESTS AB Recent observations of divergence between tree growth at high-latitude sites and temperature, as well as the decline of yellow cedar [Callitropsis nootkatensis (D. Don) Oerst. ex D.P. Little] in southeast Alaska due to warming, emphasize a need to investigate nonstationary climate response of Alaskan coastal forests to warming in other tree species. Comparison of annual tree growth in mountain hemlock [Tsuga mertensiana (Bong.) Carriere] to mean monthly temperature and precipitation data from Sitka, Alaska, from A.D. 1830s to 1990s along an elevational transect reveals nonstationarity in tree growth response to climate that suggests an ongoing biome shift. We observe a marked weakening in the positive relationship between annual growth and warmer growth season temperatures at low-elevation hemlock sites, and a concurrent increase in growth and sensitivity at higher elevations coupled with increased correlation between growth and April precipitation at all sites along our transects. As previously observed with yellow cedar, the mechanism of the hemlock biome shift may be due to an increased susceptibility of roots to damage from late frosts resulting from earlier seasonal loss of protective snowpack. C1 [Jarvis, Stephanie K.; Wiles, Gregory C.; Appleton, Sarah N.] Coll Wooster, Dept Geol, Wooster, OH 44691 USA. [D'Arrigo, Rosanne D.] Columbia Univ, Lamont Doherty Earth Observ, Tree Ring Lab, Palisades, NY 10964 USA. [Lawson, Daniel E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Jarvis, SK (reprint author), So Illinois Univ, Dept Geol, 1259 Lincoln Dr, Carbondale, IL 62901 USA. EM sjarvis@siu.edu FU National Science Foundation [ATM-0902799, AGS-1202218]; National Geographic Society FX We thank Glacier Bay National Park and Preserve and the National Forest Service (U.S. Forest Service Special Use Permit FS-2700-4) for allowing us to sample the mountain hemlock and yellow-cedar trees for this study and the National Park Service for logistical support. We also thank Marilyn Loveless for the many ecology discussions pertaining to this study and are grateful for the constructive feedback of two anonymous reviewers. This work was supported by the National Science Foundation (ATM-0902799 and AGS-1202218). Part of the Excursion Ridge chronology sampling was made possible by a grant from the National Geographic Society. Lamont-Doherty contribution #7652. NR 37 TC 3 Z9 3 U1 4 U2 19 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 USA SN 1523-0430 EI 1938-4246 J9 ARCT ANTARCT ALP RES JI Arct. Antarct. Alp. Res. PD MAY PY 2013 VL 45 IS 2 BP 211 EP 218 DI 10.1657/1938-4246-45.2 PG 8 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA 287HQ UT WOS:000329533100005 ER PT J AU Rodkvamtook, W Gaywee, J Kanjanavanit, S Ruangareerate, T Richards, AL Sangjun, N Jeamwattanalert, P Sirisopana, N AF Rodkvamtook, Wuttikon Gaywee, Jariyanart Kanjanavanit, Suparat Ruangareerate, Toon Richards, Allen L. Sangjun, Noppadon Jeamwattanalert, Pimmada Sirisopana, Narongrid TI Scrub Typhus Outbreak, Northern Thailand, 2006-2007 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID ORIENTIA-TSUTSUGAMUSHI STRAINS; RICKETTSIA-TSUTSUGAMUSHI; TROMBICULID MITES; FEEDING PROCESS; TRANSMISSION; MALAYSIA; GENES AB During a scrub typhus outbreak investigation in Thailand, 4 isolates of O. tsutsugamushi were obtained and established in culture. Phylogenetic analysis based on the 56-kDa type-specific antigen gene demonstrated that the isolates fell into 4 genetic clusters, 3 of which had been previously reported and 1 that represents a new genotype. C1 [Rodkvamtook, Wuttikon] Armed Forces Res Inst Med Sci, Pathol Sect, Div Res, Royal Thai Army Component, Bangkok 10400, Thailand. [Gaywee, Jariyanart; Ruangareerate, Toon; Sangjun, Noppadon; Jeamwattanalert, Pimmada; Sirisopana, Narongrid] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kanjanavanit, Suparat] Nakhornping Hosp, Chiang Mai, Thailand. [Richards, Allen L.] Naval Med Res Ctr, Silver Spring, MD USA. RP Gaywee, J (reprint author), Armed Forces Res Inst Med Sci, Royal Thai Amy, Bangkok 10400, Thailand. EM jariyanartg@afrims.org FU Royal Thai Army; Thailand Tropical Diseases Research Funding Program [T-2]; Thanphuying Viraya Chavakul Foundation for Medical Armed Forces Research Grant; Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [0000188M.0931.001.A0074] FX Support for this study was provided by the Royal Thai Army (to W.R.); the Thailand Tropical Diseases Research Funding Program (T-2; to J.G.); the Thanphuying Viraya Chavakul Foundation for Medical Armed Forces Research Grant (to T.R.); and the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center (work unit no. 0000188M.0931.001.A0074) (to A.L.R.). NR 15 TC 7 Z9 9 U1 3 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2013 VL 19 IS 5 BP 774 EP 777 DI 10.3201/eid1905.121445 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 268LX UT WOS:000328173400012 PM 23647883 ER PT J AU Song, MC Sankar, BV Subhash, G Yen, CF AF Song, M. C. Sankar, B. V. Subhash, G. Yen, C. F. TI Finite Element Analysis of Delamination in Woven Composites under Quasi-Static Indentation SO CMC-COMPUTERS MATERIALS & CONTINUA LA English DT Article DE 3D woven composites; plain woven laminate; FEM cohesive element; delamination ID NUMERICAL-SIMULATION; DAMAGE; TOUGHNESS; FRACTURE; PROPAGATION; CRACKS; BEAMS; MODEL; PINS AB Delamination initiation and propagation in plain woven laminates and 3D orthogonal woven composites during short beam shear (SBS) test were analyzed using finite element (FE) analyses. Two kinds of 3D woven composites, containing single z-yarns and double z-yarns, were considered. The FE models were guided by experimental observations from SBS tests for the same material systems. A series of mechanisms including creation and evolution of matrix cracks and delaminations were modeled discretely. The force-displacement curves obtained from the FE simulations were compared with those from experiments. Further parametric studies were conducted to investigate the effects of z-yams and interlaminar fracture toughness on delamination in woven composites. The results from the FE simulations revealed that z-yarns in 3D woven composites can play a major role in impeding propagation of interlaminar cracks. On the other hand 2D plain woven laminates without any z-reinforcement demonstrated higher interlaminar fracture toughness due to undulation in yams. 3D woven composites with double yams showed better damage tolerance than single yarn 3D woven composites and their behavior was very similar to composite laminates with high interlaminar fracture toughness. C1 [Song, M. C.; Sankar, B. V.; Subhash, G.] Univ Florida, Gainesville, FL 32610 USA. [Yen, C. F.] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Song, MC (reprint author), Univ Florida, Gainesville, FL 32610 USA. FU United States Army Research Office [W911NF-08-1-0120]; United States Army Research Laboratory FX The funding for this work was provided by the United States Army Research Office (grant number W911NF-08-1-0120) and the United States Army Research Laboratory. The authors also would liketo thank Dr. Bazle Z. (Gama) Hague at the University of Delaware for the personal communication about the volume fraction of yarns in 3D woven composites. NR 33 TC 0 Z9 0 U1 0 U2 6 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1546-2218 EI 1546-2226 J9 CMC-COMPUT MATER CON JI CMC-Comput. Mat. Contin. PD MAY PY 2013 VL 35 IS 1 BP 67 EP 85 PG 19 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Materials Science; Mathematics GA 255GG UT WOS:000327226800005 ER PT J AU Carlucci, DE Frydman, AM Cordes, JA AF Carlucci, D. E. Frydman, A. M. Cordes, J. A. TI Mathematical Description of Projectile Shot Exit Dynamics (Set-Forward) SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc DE muzzle exit; gun launch; dynamics; mathematics; ringing; set-forward; accelerometers AB The dynamics or "ringing" of a projectile structure at gun-muzzle exit has been observed to cause a large number of electronics failures in projectiles as well as possible safety concerns with respect to components impacting one another or structural components of the projectile coming apart. Current numerical tools allow accurate calculation of the muzzle exit event given that the engineer understands the forces acting on the projectile. Dynamic response of a structure is well understood by persons working in the field; however, engineers who do not regularly deal with dynamic analyses generally have difficulty interpreting results from both analyses and tests. This paper details the mathematics associated with this event so that the engineer confronted with a dynamics related issue can have a reference for understanding and interpretation. The results of a simple model show that accelerometer data should be used with caution and the support of a finite element analysis of the projectile structure with the proper pressure decay is usually necessary. Recommendations for use of measured acceleration data for modeling and simulation are provided. C1 [Carlucci, D. E.; Cordes, J. A.] US Army ARDEC RDAR DSM, Picatinny Arsenal, NJ 07806 USA. [Frydman, A. M.] Army Res Lab, Adelphi, MD 20783 USA. RP Carlucci, DE (reprint author), US Army ARDEC RDAR DSM, Bldg 94,2nd Floor, Picatinny Arsenal, NJ 07806 USA. NR 19 TC 1 Z9 1 U1 0 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 EI 1528-9036 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAY PY 2013 VL 80 IS 3 SI SI AR 031501 DI 10.1115/1.4023335 PG 9 WC Mechanics SC Mechanics GA 241OI UT WOS:000326176200010 ER PT J AU Manning, TG Leone, J Zebregs, M Ramlal, DR van Driel, CA AF Manning, Thelma G. Leone, Joseph Zebregs, Martijn Ramlal, Dinesh R. van Driel, Chris A. TI Definition of a JA-2 Equivalent Propellant to be Produced by Continuous Solventless Extrusion SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc AB In order to eliminate residual solvents in ammunition and to reduce the emissions of volatile organic compounds to the atmosphere, the U. S. Army ARDEC has teamed with TNO in developing a new process for the production of solventless propellant for tank ammunition. To reduce the costs of solventless propellants production, shear roll mill and continuous extrusion processing was investigated. As described in this paper JA-2 a double base propellant cannot be processed without solvent by the extrusion process. An alternative JA-2 equivalent propellant was defined. The aim of this work is to demonstrate the manufacturing of this propellant by solventless continuous twin screw extrusion processing while maintaining gun performance characteristics of conventional JA-2 propellant. This is elucidated by explicitly researching the relationship between interior ballistic properties of the gun propellant and utilizing a continuous manufacturing process. Processing conditions were established, and the propellant was manufactured accordingly. The extruded propellant has the desired properties, which resulted in a comparable gun performance as the conventional JA-2 propellant. C1 [Manning, Thelma G.; Leone, Joseph] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Zebregs, Martijn; Ramlal, Dinesh R.; van Driel, Chris A.] TNO, NL-2288 GJ Rijswijk, Netherlands. RP Manning, TG (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM thelma.g.manning.civ@mail.mil; martijn.zebregs@tno.nl NR 10 TC 1 Z9 1 U1 0 U2 5 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 EI 1528-9036 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAY PY 2013 VL 80 IS 3 SI SI AR 031405 DI 10.1115/1.4023315 PG 7 WC Mechanics SC Mechanics GA 241OI UT WOS:000326176200006 ER PT J AU Strassburger, E Hunzinger, M Patel, P McCauley, JW AF Strassburger, Elmar Hunzinger, Martin Patel, Parimal McCauley, James W. TI Analysis of the Fragmentation of AlON and Spinel Under Ballistic Impact SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc DE fragmentation; ceramic; AlON; magnesium aluminate spinel; high-speed photography; laser light-sheet technique ID TRANSPARENT ARMOR; PROPAGATION; CERAMICS; FRACTURE; FAILURE; CRACKS; GLASS AB It has been demonstrated that significant weight reductions can be achieved, compared to conventional glass-based armor, when a transparent ceramic is used as the strike face on a glass-polymer laminate. Magnesium aluminate spinel (MgAl2O4) and AlON are promising candidate materials for application as a hard front layer in transparent armor. Comprehensive, systematic investigations of the fragmentation of ceramics have shown that the mode of fragmentation is one of the key parameters influencing the ballistic resistance of ceramics. In the study described here, the fragmentation of AlON and three types of spinel was analyzed: two types of fine grained spinel with nominal average grain sizes 0.6 mu m and 1.6 mu m and a bimodal grain-sized spinel with large grains of 250 mu m size in a fine grain (5-20 mu m) matrix were examined. The ceramic specimens of 6-mm thickness were glued to an aluminum backing and impacted with armor piercing (AP) projectiles of caliber 7.62 mm at two different velocities-850 m/s and 1100 m/s. The targets were integrated into a target box, which allowed for an almost complete recovery and analysis of the ceramic fragments. Different types of high-speed cameras were applied in order to visualize the different phases of fragment formation and ejection. A laser light-sheet illumination technique was applied in combination with high-speed cameras in order to determine size and speed of ejected ceramic fragments during projectile penetration. The application of the visualization techniques allowed for the analysis of the dynamics of the fragment formation and interaction with the projectile. A significant difference in the fragment size distributions of bimodal grain-sized spinel and AlON was observed. C1 [Strassburger, Elmar; Hunzinger, Martin] Ernst Mach Inst, Fraunhofer Inst High Speed Dynam, D-79400 Kandern, Germany. [Patel, Parimal; McCauley, James W.] US Army Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Strassburger, E (reprint author), Ernst Mach Inst, Fraunhofer Inst High Speed Dynam, Christianswuhr 2, D-79400 Kandern, Germany. EM elmar.strassburger@emi.fraunhofer.de NR 19 TC 2 Z9 2 U1 3 U2 32 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 EI 1528-9036 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAY PY 2013 VL 80 IS 3 SI SI AR 031807 DI 10.1115/1.4023573 PG 11 WC Mechanics SC Mechanics GA 241OI UT WOS:000326176200025 ER PT J AU Kondle, S Alvarado, JL Marsh, C AF Kondle, Satyanarayana Alvarado, Jorge L. Marsh, Charles TI Laminar Flow Forced Convection Heat Transfer Behavior of a Phase Change Material Fluid in Microchannels SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article DE phase change material fluid; microchannel; convective heat transfer; constant heat flux; constant wall temperature; effective specific heat ID CHANGE MATERIAL SLURRIES; CIRCULAR TUBE; RECTANGULAR MICROCHANNELS; SINK; PERFORMANCE; SUSPENSION; WATER AB In this paper, a phase change material (PCM) fluid (N-eicosane) is compared with pure water as heat transfer fluid. The heat transfer behavior of PCM fluid under laminar flow conditions (Reynolds number of 700) in circular and rectangular microchannels was studied numerically. In the numerical study, an effective specific heat model was used to take into account the phase change process. Heat transfer results for circular and rectangular microchannels with PCM fluid were obtained under hydrodynamically and thermally fully developed conditions. A PCM fluid in microchannels with aspect ratios of 1 to 2, 1 to 4, and 1 to 8 was found to enhance the thermal behavior of microchannels which can be beneficial in a host of cooling applications. The flow was assumed to be hydrodynamically fully developed at the inlet and thermally developing inside the microchannel. Heat transfer characteristics of PCM slurry flow in microchannels have been studied under three types of wall boundary conditions including constant axial heat flux with constant peripheral temperature (H1), constant heat flux with variable peripheral temperature (H2), and constant wall temperature (T) boundary condition. The fully developed Nusselt number was found to be higher for H1 than for H2 and T boundary conditions for all the geometries. Moreover, Nusselt number also increased with aspect ratio and was sensitive to the variations in effective specific heat. C1 [Kondle, Satyanarayana] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Marsh, Charles] US Army Corps Engineers, Engineer & Res Dev Ctr, Champaign, IL 61822 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 NR 27 TC 4 Z9 4 U1 0 U2 18 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 EI 1528-8943 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD MAY PY 2013 VL 135 IS 5 AR 052801 DI 10.1115/1.4023221 PG 11 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 241JW UT WOS:000326164000010 ER PT J AU Fortenberry, AD AF Fortenberry, Andrew D. TI Comminuted Fractures of the Femoral Neck and Scaphoid SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Fortenberry, AD (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 2013 VL 43 IS 5 BP 350 EP 350 DI 10.2519/jospt.2013.0409 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 236FV UT WOS:000325781800009 PM 23636181 ER PT J AU Ling, J Yapa, SD Benson, MJ Elkins, CJ Eaton, JK AF Ling, Julia Yapa, Sayuri D. Benson, Michael J. Elkins, Christopher J. Eaton, John K. TI Three-Dimensional Velocity and Scalar Field Measurements of an Airfoil Trailing Edge With Slot Film Cooling: The Effect of an Internal Structure in the Slot SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article ID GAS-TURBINE AIRFOILS; CUTBACK; FLOWS AB Measurements of the 3D velocity and concentration fields were obtained using magnetic resonance imaging for a pressure-side cutback film cooling experiment. The cutback geometry consisted of rectangular slots separated by straight lands; inside each of the slots was an airfoil-shaped blockage. The results from this trailing edge configuration, the "island airfoil," are compared to the results obtained with the " generic airfoil," a geometry with narrower slots, wider, tapered lands, and no blockages. The objective was to determine how the narrower lands and internal blockages affected the average film cooling effectiveness and the spanwise uniformity. Velocimetry data revealed that strong horseshoe vortices formed around the blockages in the slots, which resulted in greater coolant nonuniformity on the airfoil breakout surface and in the wake. The thinner lands of the island airfoil allowed the coolant to cover a larger fraction of the trailing edge span, giving a much higher spanwise-averaged surface effectiveness, especially near the slot exit where the generic airfoil lands are widest. C1 [Ling, Julia; Yapa, Sayuri D.; Elkins, Christopher J.; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA. [Benson, Michael J.] US Mil Acad, West Point, NY 10996 USA. RP Ling, J (reprint author), Stanford Univ, Stanford, CA 94305 USA. EM julial@stanford.edu FU National Science Foundation FX This work was supported by members of the Stanford Thermal and Fluid Sciences Affiliates Program. J. Ling was supported by a National Science Foundation Graduate Fellowship. NR 20 TC 10 Z9 10 U1 1 U2 7 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X EI 1528-8900 J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD MAY PY 2013 VL 135 IS 3 AR 031018 DI 10.1115/1.4007520 PG 8 WC Engineering, Mechanical SC Engineering GA 239KD UT WOS:000326021300018 ER PT J AU Klein, DJ Venkateswaran, S Isaacs, JT Burman, J Pham, T Hespanha, J Madhow, U AF Klein, Daniel J. Venkateswaran, Sriram Isaacs, Jason T. Burman, Jerry Pham, Tien Hespanha, Joao Madhow, Upamanyu TI Localization with Sparse Acoustic Sensor Network Using UAVs as Information-Seeking Data Mules SO ACM TRANSACTIONS ON SENSOR NETWORKS LA English DT Article DE Algorithms; Performance; Routing; acoustic source localization; large scale; heterogeneous; time of arrival; angle of arrival; UAV routing ID OPTIMIZATION AB We propose and demonstrate a novel architecture for on-the-fly inference while collecting data from sparse sensor networks. In particular, we consider source localization using acoustic sensors dispersed over a large area, with the individual sensors located too far apart for direct connectivity. An Unmanned Aerial Vehicle (UAV) is employed for collecting sensor data, with the UAV route adaptively adjusted based on data from sensors already visited, in order to minimize the time to localize events of interest. The UAV therefore acts as a information-seeking data mule, not only providing connectivity, but also making Bayesian inferences from the data gathered in order to guide its future actions. The system we demonstrate has a modular architecture, comprising efficient algorithms for acoustic signal processing, routing the UAV to the sensors, and source localization. We report on extensive field tests which not only demonstrate the effectiveness of our general approach, but also yield specific practical insights into GPS time synchronization and localization accuracy, acoustic signal and channel characteristics, and the effects of environmental phenomena. C1 [Klein, Daniel J.; Venkateswaran, Sriram; Isaacs, Jason T.; Hespanha, Joao; Madhow, Upamanyu] Univ Calif Santa Barbara, ECE Dept, Santa Barbara, CA 93106 USA. [Burman, Jerry] Teledyne Sci Co, Thousand Oaks, CA 91360 USA. [Pham, Tien] US Army Res Lab, Adelphi, MD 20783 USA. RP Klein, DJ (reprint author), Univ Calif Santa Barbara, ECE Dept, Santa Barbara, CA 93106 USA. EM djklein@gmail.com RI Hespanha, Joao/C-2569-2008 OI Hespanha, Joao/0000-0003-2809-4718 FU Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W911NF-09-0001] FX The work was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 41 TC 3 Z9 3 U1 0 U2 11 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1550-4859 J9 ACM T SENSOR NETWORK JI ACM Trans. Sens. Netw. PD MAY PY 2013 VL 9 IS 3 AR 30 DI 10.1145/2480730.2480733 PG 29 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 208UG UT WOS:000323705400003 ER PT J AU Byron, MM Valcour, V Ananworanich, J Agsalda, M Chalermchai, T Tipsuk, S Sithinamsuwan, P Schuetz, A Hutchings, N Barbour, J Phanuphak, N Shikuma, C Shiramizu, B Ndhlovu, L AF Byron, Mary Margaret Valcour, Victor Ananworanich, Jintanat Agsalda, Melissa Chalermchai, Thep Tipsuk, Somporn Sithinamsuwan, Pasiri Schuetz, Alexandra Hutchings, Nicholas Barbour, Jason Phanuphak, Nittaya Shikuma, Cecilia Shiramizu, Bruce Ndhlovu, Lishomwa TI CD16+expressing monocyte subsets and CD14+HIV DNA levels predict HIV-associated neurocognitive disorders (HAND) in treatment-naive HIV infected Thai subjects SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Byron, Mary Margaret; Agsalda, Melissa; Barbour, Jason; Phanuphak, Nittaya; Shikuma, Cecilia; Shiramizu, Bruce; Ndhlovu, Lishomwa] Univ Hawaii Manoa, Honolulu, HI 96822 USA. [Valcour, Victor; Hutchings, Nicholas] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Ananworanich, Jintanat; Chalermchai, Thep; Tipsuk, Somporn; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Bangkok, Thailand. [Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA P3043 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987102220 ER PT J AU Kim, A Hartman, I Poore, B Boronina, T Lanar, D Krzych, U Cole, R Sadegh-Nasseri, S AF Kim, Ae Hartman, Isamu Poore, Bradley Boronina, Tatiana Lanar, David Krzych, Urszula Cole, Robert Sadegh-Nasseri, Scheherazade TI Cooperative functions of MHC II, HLA-DM, and cathepsins enhance the selection of immunodominant epitopes SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Kim, Ae; Poore, Bradley; Boronina, Tatiana; Cole, Robert; Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Hartman, Isamu] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Lanar, David; Krzych, Urszula] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA 415 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987106121 ER PT J AU Konduru, K Shurtleff, A Bavari, S Kaplan, G AF Konduru, Krishnamurthy Shurtleff, Amy Bavari, Sina Kaplan, Gerardo TI Evaluation of ebolavirus glycoprotein Fc fusion protein as a subunit vaccine SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Konduru, Krishnamurthy; Kaplan, Gerardo] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA. [Shurtleff, Amy; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA P4417 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987105231 ER PT J AU Lieberman, M Lehrer, A Humphreys, T Johns, L Wong, TA Olinger, G Dye, J Carrion, R Patterson, J Marzi, A Feldmann, H AF Lieberman, Michael Lehrer, Axel Humphreys, Tom Johns, Lisa Wong, Teri-Ann Olinger, Gene Dye, John Carrion, Ricardo Patterson, Jean Marzi, Andrea Feldmann, Heinz TI Recombinant Ebolavirus antigens from insect cells are potent immunogens inducing cellular and humoral immunity in rodents and non-human primates and provide protection against virus challenge SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Lieberman, Michael] Lieberman Consulting, Honolulu, HI USA. [Lehrer, Axel; Johns, Lisa; Wong, Teri-Ann] PanThera Biopharma LLC, Aiea, HI USA. [Humphreys, Tom] Univ Hawaii, Honolulu, HI 96822 USA. [Olinger, Gene; Dye, John] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Carrion, Ricardo; Patterson, Jean] Texas Biomed Res Inst, San Antonio, TX USA. [Marzi, Andrea; Feldmann, Heinz] NIAID, NIH, Hamilton, MT USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA P4325 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987105140 ER PT J AU Rao, M Peachman, K Jobe, O Kuaban, A Billings, E Guao, G Wieczorek, L Polonis, V Pinter, A Kim, J Michael, N Alving, C Rao, V AF Rao, Mangala Peachman, Kristina Jobe, Ousman Kuaban, Alice Billings, Erik Guao, Guofen Wieczorek, Lindsay Polonis, Victoria Pinter, Abraham Kim, Jerome Michael, Nelson Alving, Carl Rao, Venigalla TI Induction of linear and conformational V2-specific antibodies using HIV-1 gp145 clade B envelope protein as the immunogen SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Rao, Mangala; Peachman, Kristina; Jobe, Ousman; Billings, Erik; Wieczorek, Lindsay; Polonis, Victoria; Kim, Jerome; Michael, Nelson; Alving, Carl] Walter Reed Army Inst Res, USMHRP, Silver Spring, MD USA. [Kuaban, Alice; Guao, Guofen; Rao, Venigalla] Catholic Univ Amer, Washington, DC 20064 USA. [Pinter, Abraham] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA 17915 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987106067 ER PT J AU Zarling, S Krzych, U AF Zarling, Stasya Krzych, Urszula TI Increased apoptosis of intrahepatic central memory CD8 T cells in the absence of IL-15 is attributed to the loss of long-lasting protection against malaria infection SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 100th Annual Meeting of the American-Association-of-Immunologists CY MAY 03-07, 2013 CL Honolulu, HI SP Amer Assoc Immunologists C1 [Zarling, Stasya; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2013 VL 190 MA P3334 PG 1 WC Immunology SC Immunology GA 199ID UT WOS:000322987104009 ER PT J AU Napier, BA Burd, EM Satola, SW Cagle, SM Ray, SM McGann, P Pohl, J Lesho, EP Weiss, DS AF Napier, Brooke A. Burd, Eileen M. Satola, Sarah W. Cagle, Stephanie M. Ray, Susan M. McGann, Patrick Pohl, Jan Lesho, Emil P. Weiss, David S. TI Clinical Use of Colistin Induces Cross-Resistance to Host Antimicrobials in Acinetobacter baumannii SO MBIO LA English DT Article ID PEPTIDE; POLYMYXIN; LYSOZYME; PATHOGEN AB The alarming rise in antibiotic resistance has led to an increase in patient mortality and health care costs. This problem is compounded by the absence of new antibiotics close to regulatory approval. Acinetobacter baumannii is a human pathogen that causes infections primarily in patients in intensive care units (ICUs) and is highly antibiotic resistant. Colistin is one of the last-line antibiotics for treating A. baumannii infections; however, colistin-resistant strains are becoming increasingly common. This cationic antibiotic attacks negatively charged bacterial membranes in a manner similar to that seen with cationic antimicrobials of the innate immune system. We therefore set out to determine if the increasing use of colistin, and emergence of colistin-resistant strains, is concomitant with the generation of cross-resistance to host cationic antimicrobials. We found that there is indeed a positive correlation between resistance to colistin and resistance to the host antimicrobials LL-37 and lysozyme among clinical isolates. Importantly, isolates obtained before and after treatment of individual patients demonstrated that colistin use correlated with increased resistance to cationic host antimicrobials. These data reveal the overlooked risk of inducing cross-resistance to host antimicrobials when treating patients with colistin as a last-line antibiotic. IMPORTANCE Increased use of the cationic antibiotic colistin to treat multidrug-resistant Acinetobacter baumannii has led to the development of colistin-resistant strains. Here we report that treatment of patients with colistin can induce not only increased resistance to colistin but also resistance to host cationic antimicrobials. This worrisome finding likely represents an example of a broader trend observed in other bacteria against which colistin is used therapeutically such as Pseudomonas aeruginosa and Klebsiella pneumoniae. Furthermore, these data suggest that the possible future use of an array of cationic antimicrobial peptides in development as therapeutics may have unintended negative consequences, eventually leading to the generation of hypervirulent strains that are resistant to innate host defenses. The potential for the induction of cross-resistance to innate immune antimicrobials should be considered during the development of new therapeutics. C1 [Napier, Brooke A.; Weiss, David S.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Napier, Brooke A.; Weiss, David S.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [Burd, Eileen M.; Satola, Sarah W.; Cagle, Stephanie M.; Ray, Susan M.; Weiss, David S.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. [Satola, Sarah W.] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA. [Satola, Sarah W.; Cagle, Stephanie M.; Ray, Susan M.] Georgia Emerging Infect Program, Atlanta, GA USA. [Burd, Eileen M.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [McGann, Patrick; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Pohl, Jan] Ctr Dis Control & Prevent, Div Sci Resources, Biotechnol Core Facil Branch, Atlanta, GA USA. [Ray, Susan M.] Grady Mem Hosp, Atlanta, GA USA. RP Weiss, DS (reprint author), Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. EM david.weiss@emory.edu RI Valle, Ruben/A-7512-2013 FU NIH [R21-AI098800] FX This work was supported by NIH grant R21-AI098800. Its contents are solely our responsibility and do not necessarily represent the official views of the NIH. NR 25 TC 15 Z9 15 U1 2 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAY-JUN PY 2013 VL 4 IS 3 AR e00021-13 DI 10.1128/mBio.00021-13 PG 5 WC Microbiology SC Microbiology GA 174WK UT WOS:000321187400003 PM 23695834 ER PT J AU Arun, P Abu-Taleb, R Valiyaveettil, M Wang, Y Long, JB Nambiar, MP AF Arun, Peethambaran Abu-Taleb, Rania Valiyaveettil, Manojkumar Wang, Ying Long, Joseph B. Nambiar, Madhusoodana P. TI Extracellular cyclophilin A protects against blast-induced neuronal injury SO NEUROSCIENCE RESEARCH LA English DT Article DE Traumatic brain injury; blast exposure; cyclophilin A; SH-SY5Y cells; neuroprotection ID TRAUMATIC BRAIN-INJURY; CORTICAL-NEURONS; PHOSPHORYLATION; SURVIVAL AB Blast-induced traumatic brain injury (TBI) and subsequent neurobehavioral deficits are major disabilities suffered by the military and civilian population worldwide. Rigorous scientific research is underway to understand the mechanism of blast TBI and thereby develop effective therapies for protection and treatment. By using an in vitro shock tube model of blast TBI with SH-SY5Y human neuroblastoma cells, we have demonstrated that blast exposure leads to neurobiological changes in an overpressure and time dependent manner. Paradoxically, repeated blast exposures resulted in less neuronal injury compared to single blast exposure and suggested a potential neuroprotective mechanism involving released cyclophilin A (CPA). In the present study, we demonstrate accumulation of CPA in the culture medium after repeated blast exposures supporting the notion of extracellular CPA mediated neuroprotection. Post-exposure treatment of the cells with purified recombinant CPA caused significant protection against blast-induced neuronal injury. Furthermore, repeated blast exposure was associated with phosphorylation of the proteins ERK1/2 and Bad suggesting a potential mechanism of neuroprotection by extracellular CPA and may aid in the development of targeted therapies for protection against blast-induced TBI. (c) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. C1 [Arun, Peethambaran; Abu-Taleb, Rania; Valiyaveettil, Manojkumar; Wang, Ying; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Arun, P (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM peethambaran.arun@amedd.army.mil NR 15 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-0102 J9 NEUROSCI RES JI Neurosci. Res. PD MAY-JUN PY 2013 VL 76 IS 1-2 BP 98 EP 100 DI 10.1016/j.neures.2013.02.009 PG 3 WC Neurosciences SC Neurosciences & Neurology GA 179SH UT WOS:000321541100013 PM 23511555 ER PT J AU Sadhu, B Sturm, M Sadler, BM Harjani, R AF Sadhu, Bodhisatwa Sturm, Martin Sadler, Brian M. Harjani, Ramesh TI Analysis and Design of a 5 GS/s Analog Charge-Domain FFT for an SDR Front-End in 65 nm CMOS SO IEEE JOURNAL OF SOLID-STATE CIRCUITS LA English DT Article; Proceedings Paper CT IEEE Radio Frequency Integrated Circuits (RFIC) Symposium in Conjunction with the IEEE MTT-S International Microwave Symposium (IMS) / Microwave Week CY JUN 17-19, 2012 CL Montreal, CANADA SP IEEE, IEEE MTT S DE Analytical models; analog integrated circuits; channel bank filters; cognitive radio; demodulation; discrete cosine transforms; discrete Fourier transforms; fast Fourier transforms; FET integrated circuits; filtering; FIR filters; integrated circuit modeling; integrated circuit noise; linear circuits; mixed analog digital integrated circuits; modulation; MOS integrated circuits; multiplying circuits; multiple signal classification; OFDM; passive circuits; passive filters; phase shifters; radio-frequency integrated circuits; radio spectrum management; RF signals; sampled data circuits; signal analysis; signal detection; signal to noise ratio; software defined radio; software radio; spectral analysis; signal sampling; summing circuits; switched capacitor; switched circuits; transforms; very high speed integrated circuits ID SOFTWARE-DEFINED RADIO; RECEIVER; ARCHITECTURE AB This work describes the design of a 16 point analog domain FFT using a Charge Re-use Analog Fourier Transform (CRAFT) engine. The circuit relies on charge re-use to achieve 47 dB average output SNDR on an instantaneous input bandwidth of 5 GHz, and consumes only 3.8 mW (12.2 pJ/conv.). The CRAFT engine is used as a wide-band, low power RF front-end channelizer for software defined radio (SDR) applications. The paper also discusses the handling of circuit non-idealities for the CRAFT design: their significance, modeling, and circuit techniques for their mitigation. These techniques enable this implementation to achieve a large dynamic range even at high speeds. C1 [Sadhu, Bodhisatwa; Sturm, Martin; Harjani, Ramesh] Univ Minnesota, Minneapolis, MN 55455 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Sadhu, B (reprint author), Univ Minnesota, Minneapolis, MN 55455 USA. EM sadhu002@umn.edu RI Sadhu, Bodhisatwa/K-7176-2014 OI Sadhu, Bodhisatwa/0000-0002-5849-9006 NR 28 TC 19 Z9 19 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9200 EI 1558-173X J9 IEEE J SOLID-ST CIRC JI IEEE J. Solid-State Circuit PD MAY PY 2013 VL 48 IS 5 BP 1199 EP 1211 DI 10.1109/JSSC.2013.2250457 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 171NO UT WOS:000320936300009 ER PT J AU Kuzhuget, AV Beilina, L Klibanov, MV Sullivan, A Nguyen, L Fiddy, MA AF Kuzhuget, Andrey V. Beilina, Larisa Klibanov, Michael V. Sullivan, Anders Lam Nguyen Fiddy, Michael A. TI Quantitative Image Recovery From Measured Blind Backscattered Data Using a Globally Convergent Inverse Method SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Experimental data; inverse scattering; quantitative imaging; remote sensing AB The goal of this paper is to introduce the application of a globally convergent inverse scattering algorithm to estimate dielectric constants of targets using time-resolved backscattering data collected by a U. S. Army Research Laboratory forward-looking radar. The processing of the data was conducted blind, i.e., without any prior knowledge of the targets. The problem is solved by formulating the scattering problem as a coefficient inverse problem for a hyperbolic partial differential equation. The main new feature of this algorithm is its rigorously established global convergence property. Calculated values of dielectric constants are in a good agreement with material properties, which were revealed a posteriori. C1 [Kuzhuget, Andrey V.] Morgan Stanley, New York, NY 10036 USA. [Beilina, Larisa] Chalmers, Dept Math Sci, S-42196 Gothenburg, Sweden. [Beilina, Larisa] Gothenburg Univ, S-40530 Gothenburg, Sweden. [Klibanov, Michael V.] Univ N Carolina, Dept Math & Stat, Charlotte, NC 28223 USA. [Sullivan, Anders; Lam Nguyen] US Army Res Lab, Adelphi, MD 20783 USA. [Fiddy, Michael A.] Univ N Carolina, Optoelect Ctr, Charlotte, NC 28223 USA. RP Kuzhuget, AV (reprint author), Morgan Stanley, New York, NY 10036 USA. EM larisa@chalmers.se; mklibanv@uncc.edu; anders.j.sullivan.civ@mail.mil; lam.h.nguyen2.civ@mail.mil; mafiddy@uncc.edu FU U. S. Army Research Laboratory; U.S. Army Research Office [W911NF-11-1-0399]; Swedish Research Council (VR); Swedish Foundation for Strategic Research (SSF) in Gothenburg Mathematical Modelling Centre; Swedish Institute FX Manuscript received March 24, 2012; revised July 22, 2012; accepted July 27, 2012. Date of publication September 21, 2012; date of current version April 18, 2013. This work was supported in part by the U. S. Army Research Laboratory and the U.S. Army Research Office under Grant W911NF-11-1-0399; by the Swedish Research Council (VR); by the Swedish Foundation for Strategic Research (SSF) in Gothenburg Mathematical Modelling Centre; and by the Swedish Institute, Visby Program. NR 21 TC 1 Z9 1 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAY PY 2013 VL 51 IS 5 BP 2937 EP 2948 DI 10.1109/TGRS.2012.2211885 PN 2 PG 12 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 171OY UT WOS:000320940000003 ER PT J AU Kumar, R Curry, M Ha, PK Califano, J Blanco, R Richmon, J AF Kumar, Rajesh Curry, Martin Ha, Patrick K. Califano, Joseph Blanco, Ray Richmon, Jeremy TI In Response To Objective Assessment in Residency-Based Training for Transoral Robotic Surgery SO LARYNGOSCOPE LA English DT Letter C1 [Kumar, Rajesh] Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA. [Curry, Martin] US Army, San Antonio, TX USA. [Ha, Patrick K.; Califano, Joseph] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA. [Ha, Patrick K.; Califano, Joseph; Blanco, Ray] Johns Hopkins Head & Neck Surg, Milton J Dance Head & Neck Ctr, Greater Baltimore Med Ctr, Baltimore, MD USA. [Richmon, Jeremy] Johns Hopkins Univ Hosp, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA. RP Kumar, R (reprint author), Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD MAY PY 2013 VL 123 IS 5 BP 1317 EP 1317 DI 10.1002/lary.23960 PG 1 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 169LR UT WOS:000320782200050 PM 23404291 ER PT J AU Hong, SK Epureanu, BI Castanier, MP AF Hong, Sung-Kwon Epureanu, Bogdan I. Castanier, Matthew P. TI Next-generation parametric reduced-order models SO MECHANICAL SYSTEMS AND SIGNAL PROCESSING LA English DT Article DE Parametric reduced order models; Thickness variation; Transformation matrix; Parameterization techniques; Interface reduction ID DYNAMIC ANALYSIS; DAMPED SYSTEMS; COMPONENT AB Novel parametric reduced-order models are proposed for fast reanalysis to predict the dynamic response of complex structures, which suffered thickness variations caused by design changes or damage in one or more substructures. Parametric reduced-order models developed previously have two important challenges to overcome to improve accuracy and performance: (a) the transformation matrix is not mathematically stable and (b) the Taylor series parameterization techniques do not capture thickness variations of the structure modeled with solid-type elements due to the highly nonlinear dependence on thickness changes. Thus, herein, a new transformation matrix and novel parameterization techniques are proposed. Usual reduced-order models have an additional challenge, namely the difficulty in reducing the interface degrees of freedom. Thus a way of reducing the interface degrees of freedom is also proposed. The predicted vibration responses of complex structures are shown to agree very well with results obtained using a much more computationally expensive commercial tool. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hong, Sung-Kwon; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, Matthew P.] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA. RP Epureanu, BI (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA. EM sungkwon@umich.edu; epureanu@umich.edu; matt.castanier@us.army.mil OI Castanier, Matthew/0000-0002-3646-382X FU Automotive Research Center, a US Army Center of Excellence for Modeling and Simulation of Ground Vehicles FX The authors gratefully acknowledge the financial support of the Automotive Research Center, a US Army Center of Excellence for Modeling and Simulation of Ground Vehicles led by the University of Michigan. NR 27 TC 7 Z9 7 U1 1 U2 13 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0888-3270 J9 MECH SYST SIGNAL PR JI Mech. Syst. Signal Proc. PD MAY-JUN PY 2013 VL 37 IS 1-2 SI SI BP 403 EP 421 DI 10.1016/j.ymssp.2012.12.012 PG 19 WC Engineering, Mechanical SC Engineering GA 148GJ UT WOS:000319232200028 ER PT J AU Guo, Q Dasgupta, D Doll, TAPF Burkhard, P Lanar, DE AF Guo, Qin Dasgupta, Debleena Doll, Tais A. P. F. Burkhard, Peter Lanar, David E. TI Expression, purification and refolding of a self-assembling protein nanoparticle (SAPN) malaria vaccine SO METHODS LA English DT Article DE Malaria; Nanoparticles; Vaccine; P. falciparum; Circumsporozoite protein ID PEPTIDE NANOPARTICLES; DISPLAY; DESIGN; SERVE AB There are many ways to present antigens to the immune system. We have used a repetitive antigen display technology that relies on the self-assembly of 60 protein chains into a spherical self-assembling protein nanoparticle (SAPN) to develop a vaccine against Plasmodium falciparum malaria. The protein sequence contains selected B- and T-cell epitopes of the circumsporozoite protein of P. falciparum (PfCSP) and, when assembled into a nanoparticle induces strong, long-lived and protective immune responses against the PfCSP. Here we describe the conditions needed for promoting self-assembly of a P. falciparum vaccine nanoparticle, PfCSP-KMY-SAPN, and note pitfalls that may occur when determining conditions for other SAPN vaccines. Attention was paid to selecting processes that were amenable to scale up and cGMP manufacturing. Published by Elsevier Inc. C1 [Guo, Qin; Dasgupta, Debleena; Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Doll, Tais A. P. F.; Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA. RP Lanar, DE (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM david.e.lanar.civ@mail.mil FU Military Infectious Disease Research Program (MIDRP); NIH Grant [1R01AI068761] FX Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. Work was funded by the Military Infectious Disease Research Program (MIDRP) and the NIH Grant 1R01AI068761. PB has an interest in the company Alpha-O Peptides that has patents or patents pending on the technology. NR 7 TC 5 Z9 6 U1 3 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-2023 J9 METHODS JI Methods PD MAY 1 PY 2013 VL 60 IS 3 BP 242 EP 247 DI 10.1016/j.ymeth.2013.03.025 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 173QE UT WOS:000321093200004 PM 23548672 ER PT J AU Miranda, LE Killgore, KJ Hoover, JJ AF Miranda, L. E. Killgore, K. J. Hoover, J. J. TI Fish Assemblages in Borrow-Pit Lakes of the Lower Mississippi River SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID FLOODPLAIN ECOSYSTEMS; AQUATIC HABITATS; CONNECTIVITY; REPRODUCTION; SYSTEM; RECRUITMENT; MANAGEMENT; AUSTRIA; RHINE; PONDS AB Borrow-pit lakes encompass about a third of the lentic water habitats (by area) in the active floodplain of the Lower Mississippi River, yet little is known about their fish assemblages. We investigated whether fish assemblages supported by borrow-pit lakes resembled those in oxbow lakes to help place the ecological relevance of borrow-pit lakes in context with that of natural floodplain lakes. In all, we collected 75 fish species, including 65 species in eight borrow-pit lakes, 52 species in four riverside oxbow lakes, and 44 species in eight landside oxbow lakes. Significant differences in several species richness metrics were evident between borrow-pit lakes and landside oxbow lakes but not between borrow-pit lakes and riverside oxbow lakes. All three lake types differed in fish assemblage composition. Borrow-pit lakes and riverside oxbow lakes tended to include a greater representation of fish species that require access to diverse environments, including lentic, lotic, and palustrine habitats; fish assemblages in landside oxbow lakes included a higher representation of lacustrine species. None of the fish species collected in borrow-pit lakes was federally listed as threatened or endangered, but several were listed as species of special concern by state governments in the region, suggesting that borrow-pit lakes provide habitat for sensitive riverine and wetland fish species. Differences in fish assemblages among borrow-pit lakes were linked to engineered morphologic features, suggesting that diversity in engineering can contribute to diversity in fish assemblages; however, more research is needed to match engineering designs with fish assemblage structures that best meet conservation needs. Received September 21, 2012; accepted December 17, 2012 C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA. [Killgore, K. J.; Hoover, J. J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA. EM smiranda@usgs.gov FU USACE Mississippi Valley Division; ERDC Ecosystem Management and Restoration Research Program FX Selection and access to borrow-pit lakes were facilitated by the following personnel of the U.S. Army Corps of Engineers (USACE) Vicksburg District and USACE Memphis District: M. Cannon, S. McLean, L. Hartzog, E. Lambert, K. Parrish, S. Reed, G. Williams, and G. Young. Assistance with field sampling was provided by U.S. Army Engineer Research and Development Center (ERDC) personnel, including R. Adams, S. George, S. Harrel, J. Kirk, B. Lewis, J. Morrow, C. Murphy, T. Robinson, and L. Sanders. Assistance in the field and with identification and curation of juvenile and adult fishes was provided by N. Douglas (University of Louisiana, Monroe). Funding for borrow-pit sampling was provided by the USACE Mississippi Valley Division and the ERDC Ecosystem Management and Restoration Research Program. B. Alford (Louisiana Department of Wildlife and Fisheries) and G. Lucas (Mississippi Department of Wildlife, Fisheries, and Parks) facilitated the oxbow lakes data. The use of trade names or products does not constitute endorsement by the U.S. Government. NR 48 TC 0 Z9 0 U1 1 U2 16 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD MAY 1 PY 2013 VL 142 IS 3 BP 596 EP 605 DI 10.1080/00028487.2012.760486 PG 10 WC Fisheries SC Fisheries GA 167OV UT WOS:000320642200002 ER PT J AU McMichael, IT Zaghloul, AI Mirotznik, MS AF McMichael, Ian T. Zaghloul, Amir I. Mirotznik, Mark S. TI A Method for Determining Optimal EBG Reflection Phase for Low Profile Dipole Antennas SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Electromagnetic band gap (EBG); low profile antenna; reflection phase AB An analytical method for determining the optimal reflection phase of an electromagnetic band gap (EBG) ground plane to match a low profile dipole antenna is introduced. Image theory is used to incorporate the near field coupling between a dipole antenna and the ground plane. The main contribution of this paper is to show that the optimal EBG reflection phase can be determined at discrete frequencies where a theoretically perfect return loss occurs. The optimal reflection phase is then obtained over a wider frequency band of interest and is related to the antenna's return loss for a given feed impedance and antenna height above the EBG. The resulting reflection phase can be used as a reference for designing an EBG ground plane that is well matched to the antenna without time consuming iterative full wave numerical simulations. Numerical modeling results are compared to the optimal return loss derived from the analytical method to validate the design process. It is also shown that, for certain antennas, vias are not always necessary in the construction of the EBG, which eases the manufacturing process. Finally, a dipole and EBG are constructed using the optimal design method and measurements are compared to the simulations. C1 [McMichael, Ian T.] Univ Delaware, Newark, DE 19716 USA. [McMichael, Ian T.] USA, CERDEC RDECOM NVESD, Ft Belvoir, VA 22060 USA. [Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. [Mirotznik, Mark S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP McMichael, IT (reprint author), Univ Delaware, Newark, DE 19716 USA. EM mirotzni@ece.udel.edu NR 8 TC 7 Z9 7 U1 0 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 2013 VL 61 IS 5 BP 2411 EP 2417 DI 10.1109/TAP.2013.2244552 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 157BP UT WOS:000319870700007 ER PT J AU Heegard, KD Tilley, MA Stewart, IJ Edgecombe, HP Lundy, JB Renz, EM Chung, KK AF Heegard, Kelly D. Tilley, Molly A. Stewart, Ian J. Edgecombe, Harcourt P. Lundy, Jonathan B. Renz, Evan M. Chung, Kevin K. TI Anaphylactoid reaction during first hemofiltration with a PUREMA (R) polysulfone membrane SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS LA English DT Article DE Hemodialysis; Hemo filtration; Hypersensitivity reaction; Acute kidney injury; Dialyzer reaction ID HYPERSENSITIVITY REACTIONS; HEMODIALYSIS; DIALYZER AB Adverse reactions during hemodialysis are extremely common and include a wide range of clinical presentations from mild to life threatening. We present a case of a 34 year old woman in the Burn Intensive Care Unit, who developed acute kidney injury requiring renal replacement therapy. She was placed on continuous veno-venous hemofiltration with the NxStage (R) machine which uses a synthetic PUREMA (R) polyethersulfone filter sterilized by gamma radiation. Within two minutes of initiating hemofiltration, the patient complained of pruritus as well as dyspnea and became flushed and agitated. She subsequently developed hypotension ultimately resulting in cardiopulmonary arrest. Cardiopulmonary resuscitation was initiated and the patient was given epinephrine with return of spontaneous circulation. The following day, the patient was rechallenged with a PUREMA (R) filter, and had a similar reaction with flushing, dyspnea, pruritus and hypotension requiring treatment to be discontinued. The patient was transitioned to the Prismaflex filter, another synthetic membrane, which she tolerated well and continued to utilize through the remainder of her hospital course without complication. Her clinical presentation was consistent with an anaphylactoid reaction, though a tryptase level was not obtained and a radioallergosorbent test performed with membrane material was negative. This case shows the difficulty of identifying the cause of hypersensitivity reactions involving synthetic membranes not sterilized by ethylene oxide, a commonly use sterilizing agent known to cause hypersensitivity reactions. This rare, but potentially fatal reaction has not previously been reported with a PUREMA (R) filter and this case should raise awareness of hypersensitivity reactions with this widely used method of renal replacement therapy. C1 [Heegard, Kelly D.; Tilley, Molly A.; Stewart, Ian J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Edgecombe, Harcourt P.; Lundy, Jonathan B.; Renz, Evan M.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, ATTN Nephrol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM ian.stewart@us.af.mil NR 13 TC 6 Z9 6 U1 1 U2 10 PU WICHTIG EDITORE PI MILAN PA 72/74 VIA FRIULI, 20135 MILAN, ITALY SN 0391-3988 J9 INT J ARTIF ORGANS JI Int. J. Artif. Organs PD MAY PY 2013 VL 36 IS 5 BP 363 EP 366 DI 10.5301/ijao.5000136 PG 4 WC Engineering, Biomedical; Transplantation SC Engineering; Transplantation GA 168DD UT WOS:000320685000009 PM 23420464 ER PT J AU Doyle, K Swartz, CH Dinan, JH Myers, TH Brill, G Chen, YP VanMil, BL Wijewarnasuriya, P AF Doyle, Kevin Swartz, Craig H. Dinan, John H. Myers, Thomas H. Brill, Gregory Chen, Yuanping VanMil, Brenda L. Wijewarnasuriya, Priyalal TI Mercury cadmium selenide for infrared detection SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article AB Samples of HgCdSe alloys were grown via molecular beam epitaxy on thick ZnTe buffer layers on Si substrates. Two Se sources were used: an effusion cell loaded with 5N source material that produced a predominantly Se-6 beam and a cracker loaded with 6N material that could produce a predominantly Se-2 beam. The background electron concentration in as-grown samples was significantly reduced by switching to the Se cracker source, going from 10(17)-10(18) cm(-3) to 3-5 x 10(16) cm(-3) at 12 K. The concentration remained low even when the cracking zone temperature was lowered to produce a predominantly Se-6 beam, which strongly suggests that a major source of donor defects is impurities from the Se source material rather than Se species. Secondary ion mass spectroscopy was performed. Likely donors such as F, Br, and Cl were detected at the ZnTe interface while C, O, and Si were found at the interface and in the top 1.5 mu m from the surface in all samples measured. The electron concentration for all samples increased when annealed in a Cd or Hg overpressure and decreased when annealed under Se. This suggests the presence of native defects such as vacancies and interstitials in addition to impurities. Overall, by switching to higher purity Se material and then annealing under Se overpressures, the background electron concentration was reduced by an order of magnitude, with the lowest value achieved being 9.4 x 10(15) cm(-3) at 12 K. (C) 2013 American Vacuum Society. C1 [Doyle, Kevin; Swartz, Craig H.; Dinan, John H.; Myers, Thomas H.] Texas State Univ San Marcos, Mat Sci Engn & Commercializat Program, San Marcos, TX 78666 USA. [Brill, Gregory; Chen, Yuanping; VanMil, Brenda L.; Wijewarnasuriya, Priyalal] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20786 USA. RP Doyle, K (reprint author), Texas State Univ San Marcos, Mat Sci Engn & Commercializat Program, 749 N Commanche St, San Marcos, TX 78666 USA. EM Kevin.doyle.30.ctr@mail.mil RI Brill, Gregory/G-4877-2013; Myers, Thomas/C-3769-2013 FU US Army Research Laboratory; US Army Research Office [W911NF-10-2-0103, W911NF-10-1-0335]; Air Force Office of Scientific Research; Charles Evans Analytical Group [C0CGM100] FX Portions of this work were supported by the US Army Research Laboratory and the US Army Research Office under Contract/Grant Nos. W911NF-10-2-0103 and W911NF-10-1-0335. Additional funding was provided by the Air Force Office of Scientific Research. SIMS measurements were performed by the Charles Evans Analytical Group under contract number C0CGM100. NR 10 TC 1 Z9 2 U1 1 U2 29 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY PY 2013 VL 31 IS 3 AR 03C124 DI 10.1116/1.4798651 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 160PB UT WOS:000320130500024 ER PT J AU Novikov, SV Yu, KM Levander, A Detert, D Sarney, WL Liliental-Weber, Z Shaw, M Martin, RW Svensson, SP Walukiewicz, W Foxon, CT AF Novikov, Sergei V. Yu, Kin M. Levander, Alejandro Detert, Douglas Sarney, Wendy L. Liliental-Weber, Zuzanna Shaw, Martin Martin, Robert W. Svensson, Stefan P. Walukiewicz, Wladek Foxon, C. Thomas TI Molecular beam epitaxy of highly mismatched N-rich GaN1-xSbx and InN1-xAsx alloys SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article AB GaN materials alloyed with group V anions form the so-called highly mismatched alloys (HMAs). Recently, the authors succeeded in growing N-rich GaN1-xAsx and GaN1-xBix alloys over a large composition range by plasma-assisted molecular beam epitaxy (PA-MBE). Here, they present first results on PA-MBE growth and properties of N-rich GaN1-xSbx and InN1-xAsx alloys and compare these with GaN1-xAsx and GaN1-xBix alloys. The enhanced incorporation of As and Sb was achieved by growing the layers at extremely low growth temperatures. Although layers become amorphous for high As, Sb, and Bi content, optical absorption measurements show a progressive shift of the optical absorption edge to lower energy. The large band gap range and controllable conduction and valence band positions of these HMAs make them promising materials for efficient solar energy conversion devices. (C) 2013 American Vacuum Society. C1 [Novikov, Sergei V.; Foxon, C. Thomas] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Yu, Kin M.; Levander, Alejandro; Detert, Douglas; Liliental-Weber, Zuzanna; Walukiewicz, Wladek] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Levander, Alejandro; Detert, Douglas] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA. [Sarney, Wendy L.; Svensson, Stefan P.] USA, Res Lab, Adelphi, MD 20783 USA. [Shaw, Martin; Martin, Robert W.] Univ Strathclyde, SUPA, Dept Phys, Glasgow G4 0NG, Lanark, Scotland. RP Novikov, SV (reprint author), Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. EM Sergei.Novikov@nottingham.ac.uk RI martin, rob/A-7127-2010; OI martin, rob/0000-0002-6119-764X; Yu, Kin Man/0000-0003-1350-9642 FU EPSRC; Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy [DE-AC02-05CH11231] FX The MBE growth at the University of Nottingham and characterization at the University of Strathclyde were undertaken with support from the EPSRC. Material characterization work performed at LBNL was supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 11 TC 3 Z9 3 U1 0 U2 13 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY PY 2013 VL 31 IS 3 AR 03C102 DI 10.1116/1.4774028 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 160PB UT WOS:000320130500002 ER PT J AU Onoye, J Helm, S Koyanagi, C Fukuda, M Hishinuma, E Takeshita, J Ona, C AF Onoye, Jane Helm, Susana Koyanagi, Chad Fukuda, Michael Hishinuma, Earl Takeshita, Junji Ona, Celia TI Proportional Differences in Emergency Room Adult Patients with PTSD, Mood Disorders, and Anxiety for a Large Ethnically Diverse Geographic Sample SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Mental health; health services; ethnicity; emergency services; rural ID POSTTRAUMATIC-STRESS-DISORDER; COMORBIDITY SURVEY REPLICATION; MENTAL-HEALTH-SERVICES; DSM-IV DISORDERS; PSYCHIATRIC-DISORDERS; LIFETIME PREVALENCE; WAR VETERANS; PRIMARY-CARE; COMBAT; IRAQ AB Underserved populations often utilize the emergency room in place of primary care, particularly for short term behavioral health services. This study examined emergency department (ED) utilization rates for rurality, insurance, sex, and ethnicity in a large sample of adult patients in Hawai'i hospitals from 2000-2010 with a diagnosis of post-traumatic stress disorder (PTSD), mood disorder, or other anxiety disorder. Findings showed a higher rate of use by rural and suburban residents with a diagnosis of PTSD or other anxiety than by urban residents. Utilization of EDs by African Americans and Other Pacific Islanders with PTSD was proportionally higher than for those with mood disorders or other anxiety disorders. Military ED visits were also proportionally higher for individuals with PTSD than for those with mood or other anxiety disorders. Limited economic resources and increasingly costly mental health disorders such as PTSD highlight the importance of better understanding the needs for behavioral health services for underserved populations. C1 [Onoye, Jane; Helm, Susana; Koyanagi, Chad; Fukuda, Michael; Hishinuma, Earl; Takeshita, Junji] Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, Honolulu, HI 96813 USA. [Koyanagi, Chad; Takeshita, Junji] Queens Med Ctr, Honolulu, HI 96813 USA. [Ona, Celia] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Onoye, J (reprint author), Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, 1356 Lusitana St,4th Floor, Honolulu, HI 96813 USA. EM onoyej@dop.hawaii.edu NR 44 TC 1 Z9 1 U1 0 U2 2 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD MAY PY 2013 VL 24 IS 2 BP 928 EP 942 PG 15 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 153VU UT WOS:000319631400040 PM 23728057 ER PT J AU Cazacu, O Stewart, JB AF Cazacu, Oana Stewart, Joel B. TI Analytical criterion for porous solids containing cylindrical voids in an incompressible matrix exhibiting tension compression asymmetry SO PHILOSOPHICAL MAGAZINE LA English DT Article DE voids shape; third-invariant effects; deformation twinning; porous media ID YIELD CRITERION; PLASTIC-DEFORMATION; MECHANICAL RESPONSE; DUCTILE FRACTURE; CONSTITUTIVE LAW; POLYCRYSTALS; EVOLUTION; ZIRCONIUM; TEXTURE; METALS AB A new analytic plastic potential is developed using a rigorous limit analysis approach. Conditions of homogeneous boundary strain rate are imposed on every cylinder concentric with the cavity. It is shown that, due to the tensioncompression asymmetry of the incompressible matrix, the third invariant of the stress deviator has a strong influence on the yielding of the porous solid. New and intriguing results are obtained; namely, for axisymmetric loadings and plane strain conditions, the stress state at yielding is not hydrostatic. In the case when the matrix has the same yield in tension as in compression, the new criterion reduces to Gurson's criterion for cylindrical voids. C1 [Cazacu, Oana] Univ Florida REEF, Dept Mech & Aerosp Engn, Shalimar, FL 32539 USA. [Stewart, Joel B.] USA, Res Lab, Aberdeen, MD 21005 USA. RP Cazacu, O (reprint author), Univ Florida REEF, Dept Mech & Aerosp Engn, 1350 N Poquito Rd, Shalimar, FL 32539 USA. EM cazacu@reef.ufl.edu RI Cazacu, Oana/L-4635-2016; OI Cazacu, Oana/0000-0002-2499-9096; Stewart, Joel/0000-0002-1723-7106 NR 31 TC 2 Z9 2 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1478-6435 EI 1478-6443 J9 PHILOS MAG JI Philos. Mag. PD MAY 1 PY 2013 VL 93 IS 13 BP 1520 EP 1548 DI 10.1080/14786435.2012.746792 PG 29 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA 146RX UT WOS:000319109600005 ER PT J AU Foran, HM Garber, BG Zamorski, MA Wray, M Mulligan, K Greenberg, N Castro, CA Adler, AB AF Foran, Heather M. Garber, Bryan G. Zamorski, Mark A. Wray, Mariane Mulligan, Kathleen Greenberg, Neil Castro, Carl Andrew Adler, Amy B. TI Postdeployment Military Mental Health Training: Cross-National Evaluations SO PSYCHOLOGICAL SERVICES LA English DT Article DE military personnel; prevention; mental health training; deployment; user satisfaction ID COMBAT DEPLOYMENT; ARMED-FORCES; IRAQ; INTERVENTIONS; AFGHANISTAN; PREVALENCE; COMPONENT; PROGRAM; CARE AB Deployments increase risk for adjustment problems in service members. To mitigate this increased risk, mental health training programs have been developed and implemented in several nations. As part of a coordinated effort, three nations adapted a U. S. mental health training program that had been validated by a series of group randomized trials demonstrating improvement in postdeployment adjustment. Implementation of evidence-based programs in a new context is challenging: How much of the original program needs to remain intact in order to retain its utility? User satisfaction rates can provide essential data to assess how well a program is accepted. This article summarizes service member ratings of postdeployment mental health training and compares ratings from service members across four nations. The participating nations (Canada, New Zealand, United Kingdom, and the United States) administered mental health training to active duty military personnel in their respective nations. Following the training, military personnel completed an evaluation of the training. Overall, across the four nations, more than 70% of military personnel agreed or strongly agreed that they were satisfied with the mental health training. Although some differences in evaluations were observed across nations, components of training that were most important to overall satisfaction with the training were strikingly similar across nations. Fundamentally, it appears feasible that despite cultural and organizational differences, a mental health training program developed in one nation can be successfully adapted for use in other nations. C1 [Foran, Heather M.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Garber, Bryan G.; Zamorski, Mark A.] Canadian Forces Hlth Serv Grp, Ottawa, ON, Canada. [Wray, Mariane] Headquarters Joint Forces New Zealand, Wellington, New Zealand. [Mulligan, Kathleen; Greenberg, Neil] Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, London WC2R 2LS, England. [Castro, Carl Andrew] USA, Mil Operat Med Res Program, Med Res & Mat Command, Frederick, MD USA. RP Foran, HM (reprint author), USA, Med Res Unit Europe, APO, AE 09042 USA. EM heather.m.foran.ctr@us.army.mil NR 21 TC 2 Z9 2 U1 1 U2 6 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2013 VL 10 IS 2 SI SI BP 152 EP 160 DI 10.1037/a0032609 PG 9 WC Psychology, Clinical SC Psychology GA 156DW UT WOS:000319802300003 PM 23730961 ER PT J AU Ben Barnes, J Nickerson, A Adler, AB Litz, BT AF Ben Barnes, J. Nickerson, Angela Adler, Amy B. Litz, Brett T. TI Perceived Military Organizational Support and Peacekeeper Distress: A Longitudinal Investigation SO PSYCHOLOGICAL SERVICES LA English DT Article DE stress; posttraumatic stress; perceived organizational support; peacekeeping; structural equation modeling ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; SOCIAL SUPPORT; DEPRESSION; SYMPTOMS; PTSD; IRAQ; SYMPTOMATOLOGY; RESILIENCE; TRAUMA AB Many professions vital to the safety of society require workers to face high magnitude and potentially traumatizing events. Because this routine exposure can cause high levels of stress in workers, it is important to investigate factors that contribute to both risk of posttraumatic stress disorder (PTSD), and healthy responses to stress. Although some research has found social support to mitigate the effects of posttraumatic stress symptoms, scant research has investigated organizational support. The aim of the present study is to investigate the temporal relationship between stress symptoms and perceived organizational support in a sample of 1,039 service members deployed to the peacekeeping mission to Kosovo. Participants completed self-report measures of stress symptoms and perceived organizational support at 4 study time points. Bivariate latent difference score structural equation modeling was utilized to examine the temporal relationship among stress and perceived organizational support. In general, across the 4 time points, latent PCL scores evidenced a salient and negative relationship to subsequent POS latent difference scores. However, no significant relationship was found between latent POS variables and subsequent PCL latent difference scores. Findings suggest that prior stress symptoms are influencing service member's perceptions of the supportiveness of their organization such that increased prior stress is associated with worsening perceptions of support. These results illustrate that targeting stress directly may potentiate the positive influence of organizational support and that institutional support programs should be adapted to better account for the negative biases increased distress may encourage. C1 [Ben Barnes, J.; Litz, Brett T.] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA 02130 USA. [Nickerson, Angela] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia. [Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Litz, Brett T.] Boston Univ, Dept Psychiat, Boston, MA 02215 USA. RP Litz, BT (reprint author), VA Boston Healthcare Syst, Vet Epidemiol Res & Informat Ctr, 150 South Huntington Ave 116-B4, Boston, MA 02130 USA. EM brett.litz@va.gov NR 50 TC 0 Z9 0 U1 2 U2 20 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2013 VL 10 IS 2 SI SI BP 177 EP 185 DI 10.1037/a0032607 PG 9 WC Psychology, Clinical SC Psychology GA 156DW UT WOS:000319802300006 ER PT J AU Holthoff, EL Farrell, ME Pellegrino, PM AF Holthoff, Ellen L. Farrell, Mikella E. Pellegrino, Paul M. TI Standardized Sample Preparation Using a Drop-on-Demand Printing Platform SO SENSORS LA English DT Article DE drop-on-demand; inkjet printing; sample preparation ID TECHNOLOGY AB Hazard detection systems must be evaluated with appropriate test material concentrations under controlled conditions in order to accurately identify and quantify unknown residues commonly utilized in theater. The existing assortment of hazard reference sample preparation methods/techniques presents a range of variability and reproducibility concerns, making it increasingly difficult to accurately assess optically-based detection technologies. To overcome these challenges, we examined the optimization, characterization, and calibration of microdroplets from a drop-on-demand microdispenser that has a proven capability for the preparation of energetic reference materials. Research presented herein focuses on the development of a simplistic instrument calibration technique and sample preparation protocol for explosive materials testing based on drop-on-demand technology. Droplet mass and reproducibility were measured using ultraviolet-visible (UV-Vis) absorption spectroscopy. The results presented here demonstrate the operational factors that influence droplet dispensing for specific materials (e. g., energetic and interferents). Understanding these parameters permits the determination of droplet and sample uniformity and reproducibility (typical R-2 values of 0.991, relative standard deviation or RSD >= 5%), and thus the demonstrated maturation of a successful and robust methodology for energetic sample preparation. C1 [Holthoff, Ellen L.; Farrell, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE E, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ellen.l.holthoff.civ@mail.mil; mikella.e.farrell.civ@mail.mil; paul.m.pellegrino.civ@mail.mil NR 27 TC 9 Z9 9 U1 1 U2 25 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD MAY PY 2013 VL 13 IS 5 BP 5814 EP 5825 DI 10.3390/s130505814 PG 12 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 151FH UT WOS:000319445600025 PM 23653050 ER PT J AU Prat, N Pidcoke, HF Sailliol, A Cap, AP AF Prat, N. Pidcoke, H. F. Sailliol, A. Cap, A. P. TI Evolution of US military transfusion support for resuscitation of trauma and hemorrhagic shock SO TRANSFUSION CLINIQUE ET BIOLOGIQUE LA French DT Article DE Damage control resuscitation; Hemorrhagic shock; Acute coagulopathy of trauma; Joint Theater Trauma Registry; Fresh whole blood; 1:1:1 component therapy; Platelet:RBC; FFP:RBC; Freeze-dried plasma; Tranexamic acid ID ABDOMINAL COMPARTMENT SYNDROME; FRESH WHOLE-BLOOD; DAMAGE-CONTROL RESUSCITATION; COMBAT CASUALTY CARE; ACTIVATED FACTOR-VII; RECEIVING MASSIVE TRANSFUSIONS; EXTREMITY ARTERIAL HEMORRHAGE; EMERGENCY TOURNIQUET USE; RECOMBINANT FACTOR VIIA; CLOT-INDUCING MINERALS AB Military conflicts create a dynamic medical environment in which the number of severe trauma cases is compressed in both time and space. In consequence, lessons are learned at a rapid pace. Because the military has an effective organizational structure at its disposal and the logistical capacity to rapidly disseminate new ideas, adoption of novel therapies and protective equipment occurs quickly. The recent conflicts in Iraq and Afghanistan are no exception: more than three dozen new clinical practice guidelines were implemented by the US Armed Forces, with attendant survival benefits, in response to observation and research by military physicians. Here we review the lessons learned by coalition medical personnel regarding resuscitation of severe trauma, integrating knowledge gained from massive transfusion, autopsies, and extensive review of medical records contained in the Joint Theater Trauma Registry. Changes in clinical care included the shift to resuscitation with 1:1:1 component therapy, use of fresh whole blood, and the application of both medical devices and pharmaceutical adjuncts to reduce bleeding. Future research will focus on emerging concepts regarding coagulopathy of trauma and evaluation of promising new blood products for far-forward resuscitation. New strategies aimed at reducing mortality on the battlefield will focus on resuscitation in the pre-hospital setting where hemorrhagic death continues to be a major challenge. (C) 2013 Elsevier Masson SAS. All rights reserved. C1 [Prat, N.; Pidcoke, H. F.; Cap, A. P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Prat, N.] Inst Rech Biomed Armees, F-91223 Bretigny Sur Orge, France. [Sailliol, A.] Ctr Transfus Sanguine Armees, F-92141 Clamart, France. RP Prat, N (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM nicolas.prat@mac.com RI PRAT, Nicolas/R-4213-2016 NR 90 TC 1 Z9 1 U1 2 U2 15 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 1246-7820 J9 TRANSFUS CLIN BIOL JI Transfu. Clin. Biol. PD MAY PY 2013 VL 20 IS 2 BP 225 EP 230 DI 10.1016/j.tracli.2013.02.003 PG 6 WC Hematology; Immunology SC Hematology; Immunology GA 158YP UT WOS:000320011400029 PM 23597584 ER PT J AU Hancock, PA Mercado, JE Merlo, J Van Erp, JBF AF Hancock, Peter A. Mercado, Joseph E. Merlo, James Van Erp, Jan B. F. TI Improving target detection in visual search through the augmenting multi-sensory cues SO ERGONOMICS LA English DT Article DE auditory cueing; tactile cueing; augmented support; target detection; visual search ID TACTILE; ATTENTION; PERFORMANCE; INFORMATION; WORKLOAD; DISPLAYS; GUIDANCE; FEEDBACK; ACQUISITION; INTEGRATION AB The present experiment tested 60 individuals on a multiple screen, visual target detection task. Using a within-participant design, individuals received no-cue augmentation, an augmenting tactile cue alone, an augmenting auditory cue alone or both of the latter augmentations in combination. Results showed significant and substantive improvements in performance such that successful search speed was facilitated by more than 43%, errors of omission were reduced by 86% and errors of commission were reduced by more than 77% in the combinatorial cueing condition compared with the non-cued control. These outcomes were not a trade of performance efficiency for associated mental effort because recorded levels of cognitive workload were also reduced by more than 30% in the multi-cued circumstance compared with the control condition. When the tactile modality was incorporated it led to the highest gain in performance speed, when the auditory modality was incorporated, it led to the best levels of performance accuracy. The combined condition rendered the best of each from of performance increment. Reasons for this outcome pattern are discussed alongside their manifest practical benefits. Practitioner Summary: This experiment tested 60 individuals on a multiple screen, visual target detection task. Individuals received no-cue augmentation, tactile cue alone, an augmenting auditory cue alone or both of the latter augmentations in combination. Results showed significant and substantive improvements in the combinatorial cueing condition compared with the non-cued control. C1 [Hancock, Peter A.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. [Mercado, Joseph E.; Merlo, James] US Mil Acad, West Point, NY 10996 USA. [Van Erp, Jan B. F.] Netherlands Org Appl Sci Res TNO, Soesterberg, Netherlands. RP Mercado, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. EM jmercado85@gmail.com OI van Erp, Jan/0000-0002-6511-2850 FU Army Research Office [W911NF-08-1-0196] FX We would like to thank Cadets from the Engineering Psychology Program at the USMA for their diligence in creating the stimuli for the experiment and helping to collect the data for the present experiment. Our thanks are also due to Dr Aaron Duley for his LabView programming, which enabled the experimental protocol. The work was supported by the government contract number W911NF-08-1-0196, Adaptation of Physiological and Cognitive Workload via Interactive Multi-Modal Displays from the Army Research Office, P.A. Hancock, Principal Investigator. Dr Elmar Schmeisser was the Technical Monitor for the grant. The views expressed in this work are those of the authors and do not necessarily reflect official Army policy. NR 55 TC 11 Z9 11 U1 3 U2 18 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD MAY 1 PY 2013 VL 56 IS 5 BP 729 EP 738 DI 10.1080/00140139.2013.771219 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 146RD UT WOS:000319107300001 PM 23510197 ER PT J AU Yost, TL Taylor, AG AF Yost, Terri L. Taylor, Ann Gill TI QIGONG AS A NOVEL INTERVENTION FOR SERVICE MEMBERS WITH MILD TRAUMATIC BRAIN INJURY SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING LA English DT Review DE Mild traumatic brain injury; mTBI; qigong; reflective exercise; phenomenology; military ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CLINICAL-TRIALS; ESSENTIAL-HYPERTENSION; EXTERNAL QIGONG; TAI-CHI; SYMPTOMS; PAIN; THERAPY; BLOOD AB Purpose: To describe the experience of internal qigong practice in service members diagnosed with mild traumatic brain injury (mTBI). Theoretical Framework: The study used qualitative descriptive phenomenological methods originally described by Husserl and later refined by Giorgi. Methodology: Participants were interviewed about their experiences while learning qigong to determine their level of interest, benefits, and/or adverse effects; ease of learning/performing the routine; and any barriers to practice. Sample: Six service members with mTBI receiving outpatient neurorehabilitation at the Defense and Veterans Brain Injury Center-Charlottesville Rehabilitation Center. Intervention: Participants learned Reflective Exercise Qigong, a form of qigong developed specifically to require less complex movement and balance than most forms of qigong, making it ideal for those with potential coordination and balance issues. Data Collection: Semistructured interviews took place after four weeks of formal qigong instruction, then again after the subjects completed eight weeks. Interview data were analyzed with phenomenological methods described by Giorgi. Results: Four themes emerged from the interview data: "the physical experience of qigong," "regaining control," "no pain, a lot of gain," and "barriers to qigong practice." Participants offered examples of how qigong enabled them to control refractory symptoms after mTBI while decreasing reliance on pharmacotherapy. All agreed that qigong was uniquely conducive to the disciplined mindset of military service members and that the simplicity of Reflective Exercise qigong, compared with similar modalities such as tai chi and yoga, was well suited to individuals with decreased balance, cognition, and memory related to mTBI. C1 [Yost, Terri L.] Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA. [Taylor, Ann Gill] Univ Virginia, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA. RP Yost, TL (reprint author), Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM terri.yost@us.army.mil FU TriService Nursing Research Program grant [HU0001-1-10-TS13] FX The authors thank the Defense and Veterans Brain Injury Center (DVBIC) and its Charlottesville facility leadership: Dr Don Nidiffer, Dr Jeffrey Barth, and Dr Tina Trudel, as well as all of the providers and staff of the DVBIC-Charlottesville Rehabilitation Program who were integral in facilitating this research. This research was sponsored by the TriService Nursing Research Program grant #HU0001-1-10-TS13, Uniformed Services University of the Health Sciences; however, the information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, the Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. government. NR 33 TC 1 Z9 1 U1 5 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-8307 J9 EXPLORE-NY JI Explore-J Sci. Heal. PD MAY-JUN PY 2013 VL 9 IS 3 BP 142 EP 149 DI 10.1016/j.explore.2013.02.002 PG 8 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 150FJ UT WOS:000319375300005 PM 23643369 ER PT J AU Chad, DA Bidichandani, S Bruijn, L Capra, JD Dickie, B Ferguson, J Figlewicz, D Forsythe, M Kaufmann, P Kirshner, A Monti, W AF Chad, David A. Bidichandani, Sanjay Bruijn, Lucie Capra, J. Donald Dickie, Brian Ferguson, John Figlewicz, Denise Forsythe, Melissa Kaufmann, Petra Kirshner, Annette Monti, William TI Funding agencies and disease organizations: Resources and recommendations to facilitate ALS clinical research SO AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION LA English DT Article DE ALS; funding agencies; patient voluntary organizations AB Ten groups presented their perspectives on facilitating clinical research in ALS including four federal agencies, four disease organizations, one foundation and one advocacy group. The federal agencies (National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, Office of Rare Diseases Research, Department of Defense) encourage fostering a team approach between pre-clinical and clinical research investigators, coordinating with patient groups in the early phases of clinical studies, enhancing private and public partnerships, and investigating the interplay between genetic susceptibility and environmental exposure. The disease organizations (Muscular Dystrophy Association, ALS Association, ALS Society of Canada, and the Motor Neurone Disease Association UK) support fellowship training programs to develop ALS clinician scientists, and encourage work on the epidemiology of ALS, on genetic and epigenetic mechanisms that are relevant to ALS pathogenesis, on developing ALS registries and biobanks, and building bridges of collaboration among study groups. The Foundation supports innovative projects, including stem-cell research, and Patient Advocacy is committed to supporting excellence in ALS research and patient care, and believes strongly in enhancing communication between patients and members of the research community. C1 [Chad, David A.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Dickie, Brian] Motor Neuron Dis Assoc, Northampton, England. [Ferguson, John] NIH, Off Rare Dis Res, Bethesda, MD 20892 USA. [Figlewicz, Denise] ALS Soc Canada, Bethesda, MD USA. [Forsythe, Melissa] USA, Med Res & Mat Command, Congressionally Directed Med Res Programs Off, Bethesda, MD USA. [Kaufmann, Petra] NINDS, NIH, Bethesda, MD 20892 USA. [Kirshner, Annette] NIEHS, NIH, Bethesda, MD USA. [Monti, William] ALS Advocacy, New York, NY USA. RP Chad, DA (reprint author), Neuromuscular Diagnost Ctr, 165 Cambridge St,Suite 820,CPZ 8, Boston, MA 02114 USA. EM dchad@partners.org NR 0 TC 1 Z9 1 U1 0 U2 9 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 2167-8421 J9 AMYOTROPH LAT SCL FR JI Amyotroph. Lateral Scher. Frontotemp. Degenerat. PD MAY PY 2013 VL 14 SU 1 BP 62 EP 66 DI 10.3109/21678421.2013.778588 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA 145KH UT WOS:000319014100007 PM 23678881 ER PT J AU Cai, XP Servinsky, M Kiel, J Sund, C Bennett, GN AF Cai, Xianpeng Servinsky, Matthew Kiel, James Sund, Christian Bennett, George N. TI Analysis of redox responses during TNT transformation by Clostridium acetobutylicum ATCC 824 and mutants exhibiting altered metabolism SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Electron mediators; Metabolism; Redox; Anaerobe; Hydrogenase ID FE-ONLY HYDROGENASE; ESCHERICHIA-COLI; CONTINUOUS CULTURES; CONTAMINATED SOIL; SOLVENT FORMATION; ACETONE FORMATION; ELECTRON FLOW; 2,4,6-TRINITROTOLUENE; MUTAGENICITY; REDUCTION AB The transformation of trinitrotoluene (TNT) by several mutant strains of Clostridium acetobutylicum has been examined to analyze the maximal rate of initial transformation, determine the effects of metabolic mutations of the host on transformation rate, and to assess the cell metabolic changes brought about during TNT transformation. Little difference in the maximal rate of TNT degradation in early acid phase cultures was found between the parental ATCC 824 strain and strains altered in the acid forming pathways (phosphotransacetylase, or butyrate kinase) or in a high-solvent-producing strain (mutant B). This result is in agreement with the previous findings of a similar degradation rate in a degenerate strain (M5) that had lost the ability to produce solvent. A series of antisense constructs were made that reduced the expression of hydA, encoding the Fe-hydrogenase, or hydE and hydF, genes encoding hydrogenase maturating proteins. While the antisense hydA strain had only similar to 30 % of the activity of wild type, the antisense hydE strain exhibited a TNT degradation rate around 70 % that of the parent. Overexpression of hydA modestly increased the TNT degradation rate in acid phase cells, suggesting the amount of reductant flowing into hydrogenase rather than the hydrogenase level itself was a limiting factor in many situations. The redox potential, hydrogen evolution, and organic acid metabolites produced during rapid TNT transformation in early log phase cultures were measured. The redox potential of the acid-producing culture decreased from -370 to -200 mV immediately after addition of TNT and the hydrogen evolution rate decreased, lowering the hydrogen to carbon dioxide ratio from 1.4 to around 1.1 for 15 min. During the time of TNT transformation, the treated acidogenic cells produced less acetate and more butyrate. The results show that during TNT transformation, the cells shift metabolism away from hydrogen formation to reduction of TNT and the resulting effects on cell redox cofactors generate a higher proportion of butyrate. C1 [Bennett, George N.] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA. [Servinsky, Matthew; Kiel, James; Sund, Christian] USA, Res Lab, Adelphi, MD 20783 USA. RP Bennett, GN (reprint author), Rice Univ, Dept Biochem & Cell Biol, MS 140,6100 Main St, Houston, TX 77005 USA. EM xpcaimail@gmail.com; gbennett@rice.edu FU Army Research Office [W911NF0910119] FX This project was supported by the Army Research Office, grant number W911NF0910119. Also, we would like to thank Mary Harrison and David French for assistance with this research and data management. NR 38 TC 3 Z9 3 U1 1 U2 26 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD MAY PY 2013 VL 97 IS 10 BP 4651 EP 4663 DI 10.1007/s00253-012-4253-3 PG 13 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 141HQ UT WOS:000318716700039 PM 22843424 ER PT J AU Cole, RE Boyer, KM Spanbauer, SM Sprague, D Bingham, M AF Cole, Renee E. Boyer, Kathleen M. Spanbauer, Sean M. Sprague, Denise Bingham, Mona TI Effectiveness of Prediabetes Nutrition Shared Medical Appointments Prevention of Diabetes SO DIABETES EDUCATOR LA English DT Article ID IMPAIRED GLUCOSE-TOLERANCE; PRIMARY-CARE; WEIGHT-LOSS; COST-EFFECTIVENESS; HEART-FAILURE; MANAGEMENT; INTERVENTIONS; ADULTS; MULTIDISCIPLINARY; POPULATION AB Purpose The purpose of this study is to evaluate the effectiveness of a nutrition-based shared medical appointment (SMA) intervention in the treatment of prediabetes compared to the individualized counseling standard of care. Methods A randomized controlled trial design comparing health outcomes in patients with prediabetes attending either an individualized counseling (control group) or three 90-minute nutrition SMA (intervention group) sessions. Demographic, anthropometric (weight and body mass index), clinical (blood pressure), and biochemical (lipid profile, fasting blood sugar, glycated hemoglobin, albumin- to-creatinine ratio) measures were obtained from all participants at baseline, at 3 months, and at 1 year. Results Ninety-four participants were randomized into the 2 study groups with a 69% completion rate at 1 year (n = 34 SMA, n = 31 control). The average participant was Caucasian (64%), male (54%), 58.3 +/- 9.6 years, had a BMI of 30.8 +/- 4.9 kg/m(2) (obese), and fasting blood glucose of 109 +/- 9.5 mg/dL. The SMA and control participants lost a mean of 6.6 pounds and 3.6 pound, respectively; neither group met the 5% modest weight loss expected. The SMA and control group experienced a mean drop in fasting blood glucose of 6 mg/dL. Conclusions As demands on health care providers continue to rise, finding innovative ways to manage the patient load while providing quality health care is increasingly important. SMA health outcomes were equivalent to individual counseling outcomes, while increasing the provider's productivity by treating 6 to 8 people with prediabetes in 90 minutes compared to 1 patient in 60 minutes. C1 [Cole, Renee E.; Spanbauer, Sean M.] USA, Med Dept Ctr & Sch, Joint Base San Antonio F, TX 78234 USA. [Boyer, Kathleen M.; Sprague, Denise] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Joint Base San Antonio F, TX USA. [Bingham, Mona] Samueli Inst, Alexandria, VA USA. RP Cole, RE (reprint author), USA, Med Dept Ctr & Sch, 3599 Winfield Scott Ave, Joint Base San Antonio F, TX 78234 USA. EM renee.e.cole.mil@mail.mil FU Brooke Army Medical Center Department of Pathology FX Biochemical indices assessment was funded by Brooke Army Medical Center Department of Pathology. NR 31 TC 7 Z9 8 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0145-7217 J9 DIABETES EDUCATOR JI Diabetes Educ. PD MAY-JUN PY 2013 VL 39 IS 3 BP 344 EP 353 DI 10.1177/0145721713484812 PG 10 WC Endocrinology & Metabolism; Public, Environmental & Occupational Health SC Endocrinology & Metabolism; Public, Environmental & Occupational Health GA 148DR UT WOS:000319223600007 PM 23589326 ER PT J AU Clark, P Rooks, VJ Lustik, M AF Clark, Paul Rooks, Veronica J. Lustik, Michael TI Fast Whole-Body Magnetic Resonance Imaging of Healthy, Term Neonates: Spectrum of Incidental and Birth-Related Findings SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE fast WB-MRI; neonate; normal postpartum; fascial fluid ID CHILDREN; MRI AB Purpose: The objective of this study was to describe normal postpartum findings seen with fast whole-body magnetic resonance imaging of healthy, term neonates. Method: We prospectively analyzed whole-body 3.0-T magnetic resonance imaging of 53 normal neonates scanned within 72 hours of birth to assess for postpartum-related findings. Results: Increased T2 signal within the subcutaneous and fascial tissues was the most common finding. This pattern was seen in 73.5% of neonates, within 32% of the upper extremities and 62% of the lower extremities. Additional patterns of increased T2 signal were seen in the cervical region, joint spaces, groin, and axilla. Several of these patterns were more common in larger infants. No significant differences were seen between vaginal and cesarean deliveries. Conclusions: The presence of fascial fluid as demonstrated with whole-body magnetic resonance imaging is considered a normal finding in postpartum neonates, likely related to the birthing process of labor and not an indication of underlying pathology. C1 [Clark, Paul] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA. [Rooks, Veronica J.; Lustik, Michael] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Clark, P (reprint author), Ft Belvoir Community Hosp, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA. EM critoes@gmail.com NR 11 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAY-JUN PY 2013 VL 37 IS 3 BP 371 EP 376 DI 10.1097/RCT.0b013e3182867bc2 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 146UA UT WOS:000319116700009 PM 23674007 ER PT J AU Bier, SA Hermstad, E Trollman, C Holt, M AF Bier, Scott A. Hermstad, Erik Trollman, Christopher Holt, Melinda TI ARMY FLIGHT MEDIC PERFORMANCE OF PARAMEDIC LEVEL PROCEDURES: INDICATED VS. PERFORMED SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE military medicine; emergency medical services; air ambulance ID MEDEVAC AB Background: There is great disparity in the education, experience, and staffing requirements for civilian and Army aeromedical transports (AMT). Objective: This study sought to determine if medical skills beyond the standard training for Army flight medics were indicated and being performed on Army AMT missions. As a secondary measure, the percentage of indicated interventions performed by basic Emergency Medical Technician (EMT-B) and paramedic (EMT-P) flight medics were compared. Methods: This was a retrospective review of Army AMT charts including patients transported by an EMT-B-staffed unit in Iraq and an EMT-P-staffed unit in Afghanistan from July 2008 to June 2009. Charts were reviewed independently by two Emergency Medicine board-certified Army flight surgeons. Results: Of 984 interventions found to be indicated on the 406 charts that met inclusion criteria, 36% were rated as EMT-P level. Seventeen percent were indicated but not performed. EMT-Bs failed to perform indicated procedures 35% of the time vs. 3% in the EMT-P group (p < 0.001). For paramedic-level procedures, EMTBs failed to make 76% of appropriate interventions, compared to < 1% in the EMT-P group (p < 0.001). Conclusions: There seems to be a substantial number of procedures beyond the scope of standard Army flight medic training being required for Army AMT missions. It seems that when advance interventions are indicated, those trained to the EMT-P level perform them significantly more often than those trained to Army standard. Conclusions: Based on the findings of this study, the authors suggest the Army consider adopting the standards required for civilian AMT. Published by Elsevier Inc. C1 [Bier, Scott A.] USA, Med Corps, Dept Emergency Med, Ft Hood, TX 77380 USA. [Hermstad, Erik] USA, Med Corps, Dept Emergency Med, William Beaumont Army Med Ctr, Ft Bliss, TX USA. [Trollman, Christopher] USA, Med Corps, Ft Campbell, KY USA. [Holt, Melinda] Sam Houston State Univ, Dept Math & Stat, Huntsville, TX 77340 USA. RP Bier, SA (reprint author), USA, Med Corps, Dept Emergency Med, 4th Combat Aviat Brigade, Ft Hood, TX 77380 USA. NR 10 TC 0 Z9 0 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD MAY PY 2013 VL 44 IS 5 BP 962 EP 969 DI 10.1016/j.jemermed.2012.11.006 PG 8 WC Emergency Medicine SC Emergency Medicine GA 144CC UT WOS:000318916200020 PM 23351570 ER PT J AU Benton, CG West, MW Hall, SM Marko, ST Johnson, JC AF Benton, Carrie G. West, Michael W. Hall, Shane M. Marko, Shannon T. Johnson, Joshua C. TI Effect of Short-Term Pair Housing of Juvenile Rhesus Macaques (Macaca mulatta) on Immunologic Parameters SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID MEDIATED IMMUNE-RESPONSES; ENVIRONMENTAL ENRICHMENT; CYNOMOLGUS MONKEYS; FEMALE RHESUS; BEHAVIOR; VIRUS; CYTOKINES; KETAMINE; CELLS; EBOLA AB Social housing of nonhuman primates (NHP) in an infectious disease setting presents unique challenges, and individual housing is often scientifically justified. At our institute, we recognized an opportunity to limit individual housing to the minimal period necessary by pair-housing NHP after quarantine and separating them just before they are moved into holding rooms for infectious disease studies. To alleviate concerns that pair-housing followed by separation affects the immune system of NHP and makes them unfit as research candidates, we designed a short-term pair-housing study. After a 3-wk baseline period, juvenile rhesus macaques (age, 3 to 4 y) were paired for 7 wk and then separated for 7 wk. During the study, serum cortisol, lymphocyte subsets, and proinflammatory cytokines were measured. The average values for all parameters were significantly lower after separation than during the baseline period. We conclude that short-term pair housing is a viable option at our institute for social housing of NHP. C1 [Benton, Carrie G.; Marko, Shannon T.] USA, VMD, Med Res Inst Infect Dis, Ft Detrick, MD USA. [West, Michael W.] USA, Aerobiol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Johnson, Joshua C.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Hall, Shane M.] USA, Publ Hlth Command, Aberdeen, MD USA. RP Benton, CG (reprint author), USA, VMD, Med Res Inst Infect Dis, Ft Detrick, MD USA. EM carrie.benton@amedd.army.mil FU USAMRIID Veterinary Medicine NHP section FX Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army or the Department of Defense. We thank Dr Anna Honk and Dr Rebecca Erwin-Cohen for help in the design and conduct of the study. In addition, we thank Stacey Robinson for providing clinical laboratory support, the USAMRIID Veterinary Medicine NHP section led by SGT Steven Mraz for study support, and Dr Christine Ege for editorial review. NR 32 TC 2 Z9 2 U1 1 U2 11 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAY PY 2013 VL 52 IS 3 BP 240 EP 246 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 146NQ UT WOS:000319098200003 PM 23849405 ER PT J AU Kheirabadi, BS Terrazas, IB Hanson, MA Kragh, JF Dubick, MA Blackbourne, LH AF Kheirabadi, Bijan S. Terrazas, Irasema B. Hanson, Margaret A. Kragh, John F., Jr. Dubick, Michael A. Blackbourne, Lorne H. TI In vivo assessment of the Combat Ready Clamp to control junctional hemorrhage in swine SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Combat Ready Clamp; junctional bleeding; hemorrhage control; swine ID IRAQI INSURGENCY; MODEL; SURVIVAL; INJURIES; EFFICACY AB BACKGROUND: Junctional wounds and associated hemorrhage have become more common and more lethal in the current war. The Combat Ready Clamp (CRoC) has been developed and deployed for treating junctional hemorrhage on the battlefield. This study examined the efficacy of CRoC and its acute effects in an animal model. METHODS: Anesthetized pigs (n = 6) were subjected to laparotomy, splenectomy, and abdominal closure. Next, coagulopathy was induced in animals by hemodilution and hypothermia. The left femoral artery was isolated, punctured (6-mm hole), and allowed to bleed for 15 seconds. The groin wound was packed with gauze, and a CRoC applied and tightened until hemorrhage stopped. It was kept in place for 1 hour (treatment period) and then released for another hour or less (control-period) if animal exsanguinated. Fluid resuscitation was administered, and vascular blood flow was examined by Doppler and CT scans. After death, local tissues were collected for histology. RESULTS: CRoC generated 800 to 900 mm Hg pressure on the wounds, which stopped the hemorrhage and prevented rebleeding during the first hour in all animals. Blood loss was minimal (<= 137 mL), and mean arterial pressure remained at or higher than the target level (65 mm Hg) during this period. Removal of the clamp promptly led to rebleeding and exsanguination of five of six pigs during the second hour despite fluid resuscitation. Blood loss, survival, shock indices, and other measures were significantly (p < 0.01) different between the two periods. Doppler tests and CT scans showed no blood flow in the proximal, distal, and collateral arteries of the clamped leg. Minor inflammation was seen on blood vessels (endothelium) and nerves. CONCLUSION: CRoC functioned as an effective hemostatic adjunct for compression and control of groin hemorrhage. Although no acute histological damages were seen in compressed tissues, the short-and long-term effects of CRoC application (e.g., total ischemia) on limb function remain unknown and warrant investigation. C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Hanson, Margaret A.; Kragh, John F., Jr.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@amedd.army.mil FU US Army Medical Research and Materiel Command and Defense Health Program [201105] FX The authors have no conflict of interest to report. This article is not an endorsement of the CRoC by the authors or the US Army but is simply a report of our observations with experimental use of the device. The funding for this work was provided by the US Army Medical Research and Materiel Command and Defense Health Program (proposal 201105). The opinions or assertions expressed herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Department of Defense. NR 21 TC 14 Z9 15 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAY PY 2013 VL 74 IS 5 BP 1260 EP 1265 DI 10.1097/TA.0b013e31828cc983 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 149JZ UT WOS:000319316600018 PM 23609276 ER PT J AU Pollard, KA Gottesman, BL Rochette, LM Smith, GA AF Pollard, Katherine A. Gottesman, Bethany L. Rochette, Lynne M. Smith, Gary A. TI Swimming injuries treated in US EDs: 1990 to 2008 SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID PEDIATRIC SUBMERSION-INJURY; UNITED-STATES; RISK-FACTORS; POOLS; CHILDHOOD; EXERCISE; ASSOCIATION; PREVENTION; ETIOLOGY AB Objective: Swimming is one of the most popular recreational activities in the United States. The objective of this study was to investigate the epidemiology of the complete spectrum of injuries associated with swimming and swimming pools treated in US hospital emergency departments. Methods: Data from the National Electronic Injury Surveillance System from 1990 to 2008 were analyzed. Injury rates were calculated using US census swimming participation data. Results: An estimated 1688924 swimming injuries occurred during the 19-year study, averaging 1 injury every 6 minutes. During the study period, the number of injuries and rate of injury among individuals 7 years or older significantly increased. Within this trend, injuries peaked in 1999 and significantly decreased during the last 10 years but still showed an overall increase of 18.6% in number and 29.3% in rate from 1900 to 2008. Patients 17 years or younger accounted for 60.5% of injuries, and patients 7 to 17 years of age had a greater mean annual swimming injury rate (18.78 per 10000 participants) than patients older than 17 years (9.15). Most injuries occurred in or around a swimming pool (87.0%), and most were soft tissue injuries (54.7%), followed by strains/sprains (16.4%), fractures/dislocations (11.3%), and submersion (4.9%). Injuries to patients younger than 7 years, submersion injuries, and injuries occurring at home were more likely to result in hospital admission or fatality. Conclusions: The observed increase in injuries among individuals older than 7 years underscores the need for increased prevention efforts, including education about safe swimming practices, supervision, and environmental modifications. (c) 2013 Elsevier Inc. All rights reserved. C1 [Pollard, Katherine A.; Gottesman, Bethany L.; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA. [Pollard, Katherine A.; Gottesman, Bethany L.; Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA. [Rochette, Lynne M.] USA, Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA. RP Smith, GA (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA. EM gary.smith@nationwidechildrens.org FU National Center for Injury Prevention and Control at the Centers for Disease Control and Prevention [1H75CE001491]; Ohio State University College of Medicine FX National Center for Injury Prevention and Control at the Centers for Disease Control and Prevention (grant no. 1H75CE001491) and a medical student research scholarship from The Ohio State University College of Medicine, which provided a student research stipend for author KAP while she worked on this study.; The authors gratefully acknowledge support from the National Center for Injury Prevention and Control at the Centers for Disease Control and Prevention (grant no. 1H75CE001491) and from a medical student research scholarship from The Ohio State University College of Medicine, which provided a student research stipend for author KAP while she worked on this study. Opinions expressed in this article do not necessarily represent those of these funding organizations or the US Department of the Army. The authors also wish to acknowledge the significant contributions of Brenda J. Shields, MS, who would have been a coauthor of this study; however, she lost her battle with cancer just before completion of the manuscript. We are indebted to her invaluable scholarly input during this study and dedicate this article to her. NR 35 TC 0 Z9 1 U1 0 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD MAY PY 2013 VL 31 IS 5 BP 803 EP 809 DI 10.1016/j.ajem.2013.01.028 PG 7 WC Emergency Medicine SC Emergency Medicine GA 144UD UT WOS:000318965100009 PM 23478109 ER PT J AU Kragh, JF Beebe, DF O'Neill, ML Beekley, AC Dubick, MA Baer, DG Blackbourne, LH AF Kragh, John F., Jr. Beebe, Dorothy F. O'Neill, Michelle L. Beekley, Alec C. Dubick, Michael A. Baer, David G. Blackbourne, Lorne H. TI Performance improvement in emergency tourniquet use during the Baghdad surge SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter ID MAJOR LIMB TRAUMA C1 [Kragh, John F., Jr.; Dubick, Michael A.; Baer, David G.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Beebe, Dorothy F.] Landstuhl Reg Med Ctr, Dept Prevent Med, APO, AE 09180 USA. [O'Neill, Michelle L.] Tripler Army Med Ctr, Dept Nursing, Honolulu, HI 96859 USA. [Beekley, Alec C.] Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM John.kragh1@us.army.mil NR 7 TC 4 Z9 4 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD MAY PY 2013 VL 31 IS 5 BP 873 EP 875 DI 10.1016/j.ajem.2012.11.030 PG 4 WC Emergency Medicine SC Emergency Medicine GA 144UD UT WOS:000318965100025 PM 23481155 ER PT J AU Armistead-Jehle, P Buican, B AF Armistead-Jehle, Patrick Buican, Brett TI Comparison of Select Advanced Clinical Solutions Embedded Effort Measures to the Word Memory Test in the Detection of Suboptimal Effort SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Suboptimal effort; Symptom Validity Tests; Word Memory Test; Advanced Clinical Solutions ID SYMPTOM VALIDITY TESTS; NEUROPSYCHOLOGICAL TESTS; REPEATABLE BATTERY; MILITARY SAMPLE; EFFORT INDEX; PERFORMANCE; CLAIMANTS AB This brief report sought to evaluate the classification statistics of the Advanced Clinical Solutions (ACS) embedded measures of symptom validity in relation to the Word Memory Test (WMT), a well-established standalone measure of effort in a sample of active duty military service members with a history of mild traumatic brain injury. Results demonstrated that relative to the WMT, the ACS embedded measures had adequate specificity, but lacked sensitivity. This result is in agreement with previous studies demonstrating poor sensitivity for embedded effort measures relative to standalone Symptom Validity Tests. C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA. [Buican, Brett] Ireland Army Community Hosp, Traumat Brain Injury Clin, Ft Knox, KY USA. RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. EM patrick.jehle@amedd.army.mil NR 27 TC 4 Z9 4 U1 1 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD MAY PY 2013 VL 28 IS 3 BP 297 EP 301 DI 10.1093/arclin/act017 PG 5 WC Psychology, Clinical; Psychology SC Psychology GA 138YK UT WOS:000318547600010 PM 23535704 ER PT J AU Weber, NS Larsen, RA Fisher, JA Cowan, DN Gubata, ME Niebuhr, DW AF Weber, Natalya S. Larsen, Rakel A. Fisher, Jared A. Cowan, David N. Gubata, Marlene E. Niebuhr, David W. TI Association Between Schizophrenia and Autoimmune Diseases in the National Hospital Discharge Survey (NHDS) SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 68th Annual Scientific Meeting of the Society-of-Biological-Psychiatry CY MAY 16-18, 2013 CL San Francisco, CA SP Soc Biol Psychiat DE schizophrenia; autoimmune; comorbidity; psoriasis; diabetes C1 [Weber, Natalya S.; Larsen, Rakel A.; Fisher, Jared A.; Cowan, David N.; Gubata, Marlene E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2013 VL 73 IS 9 SU S MA 881 BP 282S EP 282S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 140RE UT WOS:000318671801191 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI New insight into liquid electrolyte of rechargeable lithium/sulfur battery SO ELECTROCHIMICA ACTA LA English DT Article DE Lithium/sulfur battery; Liquid electrolyte; Polysulfide; Quaternary ammonium; Ionic liquid ID CYCLE LIFE CHARACTERISTICS; GLYCOL) DIMETHYL ETHER; SULFUR BATTERY; IONIC LIQUID; DISCHARGE PERFORMANCE; CELLS; REVERSIBILITY; COMPOSITES; ANODE; LINO3 AB The lithium/sulfur (Li/S) cell is a liquid electrochemical system, in which the dissolution of lithium polysulfide (PS, the series of the sulfur reduction intermediates) plays an essential role in the cell's performance. In solution, the PS undergo a series of complicated disproportionations, as described by a general equation of Li2Sn -> m/8S(8) + Li2Sn-m, to form the less soluble sulfur and low-order PS, which become inactive once precipitated out of the liquid electrolyte or deposited into the pores of separator. Based on the hard and soft acids and bases (HSAB) theory, quaternary ammonium cations are expected to stabilize the PS anions through a chemical interaction between the soft acid and soft base. In this paper, we report a significant improvement in the capacity retention of a Li/S cell by introducing a tetrabutylammonium triflate (NBu4SO3CF3) or an N-methyl-N-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI) into the liquid electrolyte. For example, by using an electrolyte of 0.25 mol kg(-1) LiNO3-0.25 mol kg(-1) PYR14TFSI dissolved in a 1:1 (wt.) mixture of dimethyl ether (DME) and 1,3-dioxolane (DOL), a Li/S cell with a cathode containing 77% sulfur and a 2 mg cm(-2) sulfur loading exhibited an initial capacity of 1227 mAh g(-1) and retained a capacity of 875 mAh g(-1) after 40 cycles when cycled at 0.2 mA cm(-2) between 1.7V and 2.8 V. We contribute the improved performance to the stabilized PS anions by the added quaternary ammonium cations. Published by Elsevier Ltd. C1 USA, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 29 TC 44 Z9 47 U1 12 U2 238 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAY 1 PY 2013 VL 97 BP 226 EP 230 DI 10.1016/j.electacta.2013.02.122 PG 5 WC Electrochemistry SC Electrochemistry GA 145NU UT WOS:000319024500028 ER PT J AU Webb, RP Smith, LA AF Webb, Robert P. Smith, Leonard A. TI What next for botulism vaccine development? SO EXPERT REVIEW OF VACCINES LA English DT Article DE botulinum neurotoxin; botulism; mucosal vaccine; subunit vaccine; toxoid vaccine; viral vaccine ID CERVICAL DYSTONIA PATIENTS; NEUROTOXIN SEROTYPE-A; HIGH-LEVEL EXPRESSION; ADENOVIRUS F PROTEIN; DNA REPLICON VACCINE; CLOSTRIDIUM-BOTULINUM; LIGHT-CHAIN; IMMUNE-RESPONSE; SUBUNIT VACCINE; HEAVY-CHAIN AB Botulism is a severe neuroparalytic disease caused by the toxins produced from several Clostridium species. Botulinum neurotoxins (BoNTs) cause flaccid paralysis by inducing a blockade at voluntary motor and autonomic cholinergic junctions that, if not treated, can be fatal. Vaccination to elicit protective circulating antibodies that bind, neutralize and clear toxins before they can be internalized and affect cholinergic neurons remains the most effective form of protection against BoNT. A pentavalent BoNT toxoid vaccine administered in the USA under an Investigational New Drug protocol to at-risk workers was discontinued by the CDC in 2011 due to diminished potency and reactogenic effects. Subsequent research efforts have primarily focused on recombinant protein antigens. This review focuses on the development of a recombinant bivalent vaccine (rBV A/B) composed of purified recombinant BoNT/A and BoNT/B receptor-binding domain proteins, as well as presenting a summary of progress and issues associated with alternative vaccines currently being developed against botulism. C1 [Webb, Robert P.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM leonard.a.smith1.civ@army.mil NR 91 TC 10 Z9 10 U1 0 U2 25 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2013 VL 12 IS 5 BP 481 EP 492 DI 10.1586/ERV.13.37 PG 12 WC Immunology SC Immunology GA 143FP UT WOS:000318852500008 PM 23659297 ER PT J AU Grujicic, M Ramaswami, S Snipes, JS Yavari, R Arakere, A Yen, CF Cheeseman, BA AF Grujicic, M. Ramaswami, S. Snipes, J. S. Yavari, R. Arakere, A. Yen, C. -F. Cheeseman, B. A. TI Computational Modeling of Microstructural-Evolution in AISI 1005 Steel During Gas Metal Arc Butt Welding SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE AISI 1005; finite-element analysis; gas metal arc welding (GMAW); microstructural-evolution ID KINETICS; REAUSTENITIZATION; DIFFRACTION; NUCLEATION; PHASES; AA5083; ALLOY AB A fully coupled (two-way), transient, thermal-mechanical finite-element procedure is developed to model conventional gas metal arc welding (GMAW) butt-joining process. Two-way thermal-mechanical coupling is achieved by making the mechanical material model of the workpiece and the weld temperature-dependent and by allowing the potential work of plastic deformation resulting from large thermal gradients to be dissipated in the form of heat. To account for the heat losses from the weld into the surroundings, heat transfer effects associated with natural convection and radiation to the environment and thermal-heat conduction to the adjacent workpiece material are considered. The procedure is next combined with the basic physical-metallurgy concepts and principles and applied to a prototypical (plain) low-carbon steel (AISI 1005) to predict the distribution of various crystalline phases within the as-welded material microstructure in different fusion zone and heat-affected zone locations, under given GMAW-process parameters. The results obtained are compared with available open-literature experimental data to provide validation/verification for the proposed GMAW modeling effort. C1 [Grujicic, M.; Ramaswami, S.; Snipes, J. S.; Yavari, R.; Arakere, A.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovation Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; US Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this paper is based on work supported by two Army Research Office sponsored grants (W911NF-11-1-0207 and W911NF-09-1-0513) and two US Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). The authors are indebted to Dr. Larry C. Russell, Jr. of ARO for his continuing support and interest in this study. NR 38 TC 8 Z9 8 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD MAY PY 2013 VL 22 IS 5 BP 1209 EP 1222 DI 10.1007/s11665-012-0402-1 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 126WL UT WOS:000317652800001 ER PT J AU Brammer, AT Jordon, JB Allison, PG Barkey, ME AF Brammer, A. T. Jordon, J. B. Allison, P. G. Barkey, M. E. TI Strain-Controlled Low-Cycle Fatigue Properties of Extruded 6061-T6 Aluminum Alloy SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Editorial Material C1 [Brammer, A. T.; Jordon, J. B.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. [Allison, P. G.] USA, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. [Barkey, M. E.] Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA. RP Brammer, AT (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. EM bjordon@eng.ua.edu OI Allison, Paul/0000-0002-9041-237X NR 11 TC 3 Z9 3 U1 1 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD MAY PY 2013 VL 22 IS 5 BP 1348 EP 1350 DI 10.1007/s11665-012-0411-0 PG 3 WC Materials Science, Multidisciplinary SC Materials Science GA 126WL UT WOS:000317652800015 ER PT J AU Chong, ST Kim, HC Lee, IY Kollars, TM Sancho, AR Sames, WJ Klein, TA AF Chong, Sung Tae Kim, Heung Chul Lee, In-Yong Kollars, Thomas M., Jr. Sancho, Alfredo R. Sames, William J. Klein, Terry A. TI Comparison of Dragging and Sweeping Methods for Collecting Ticks and Determining Their Seasonal Distributions for Various Habitats, Gyeonggi Province, Republic of Korea SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE tick; sweeping; dragging; habitats; seasonal prevalence ID BORNE ENCEPHALITIS-VIRUS; BRIDGES TRAINING AREA; FIRING POINTS 10; SMALL MAMMALS; HANTAAN VIRUS; LYME-DISEASE; SCRUB TYPHUS; SOUTH-KOREA; DEER TICK; SURVEILLANCE AB As part of the 65th Medical Brigade tick-borne disease surveillance program to determine the abundance, geographical and seasonal distributions, and tick-borne pathogens present in the Republic of Korea, dragging and sweeping methods were compared to determine their efficiency for collecting ticks in grass and deciduous, conifer, and mixed forest habitats at military training sites and privately owned lands in northern Gyeonggi Province near the demilitarized zone from April-October, 2004-2005. Three species of Ixodid ticks, Haemaphysalis longicornis, Haemaphysalis flava, and Ixodes nipponensis, were collected. Overall, H. longicornis adults and nymphs were most frequently collected from grass and deciduous forest habitats, accounting for 98.2 and 66.2%, respectively, of all ticks collected. H. flava adults and nymphs were most frequently collected from conifer and mixed forests, accounting for 81.6, and 77.8%, respectively, of all ticks collected. I. nipponensis adults and nymphs accounted for 9.3% of all ticks collected from mixed forests, were less commonly collected from deciduous (4.1%) and conifer (4.1%) forests, and infrequently collected from grass habitats (0.9%). Overall, there were no significant differences between dragging and sweeping methods for the three species when the areas sampled were similar (sweeping = 2 x the area over the same transect). Adults and nymphs of H. longicornis were most commonly collected from April-August, while those of H. flava and I. nipponensis were most commonly collected during April-July and again during October. Larvae of all three species were most frequently observed from July-September. C1 [Chong, Sung Tae; Kim, Heung Chul] 65 Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA. [Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120752, South Korea. [Kollars, Thomas M., Jr.] 415 Chem Brigade, Med Sect, Greenville, SC 29605 USA. [Sames, William J.] WRAMC Forest Glen Annex, Armed Forces Pest Management Board, Washington, DC 20307 USA. [Klein, Terry A.] USA, MEDDAC Korea, Unit 15281, APO, AP 96205 USA. RP Klein, TA (reprint author), USA, MEDDAC Korea, Unit 15281, 65th Med Brigade, APO, AP 96205 USA. EM terry.klein@us.army.mil FU AFHSC-GEIS, Silver Spring, MD; National Center for Medical Intelligence, Ft. Detrick, MD FX We thank COL Hee-Choon Sam Lee, Chief, Force Health Protection and Preventive Medicine (FHP&PM), 65th Medical Brigade (MED BDE), for his dedicated support. We sincerely thank Suk-Hee Yi, FHP&PM, 65th MED BDE, for providing GIS maps of collection sites and data statistical analysis. We also thank Joel Gaydos, Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, for his encouragement and support. Funding for this work was provided through the joint partnership between the AFHSC-GEIS, Silver Spring, MD, and the National Center for Medical Intelligence, Ft. Detrick, MD. NR 41 TC 10 Z9 10 U1 1 U2 11 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2013 VL 50 IS 3 BP 611 EP 618 DI 10.1603/ME12032 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 146VT UT WOS:000319123600018 PM 23802457 ER PT J AU Kiley, KC AF Kiley, Kevin C. TI Unintended Pregnancy Among Active-Duty Women in the United States Military, 2008 and "Do Ask, Do Provide" Contraception for Women in the U.S. Military SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 [Kiley, Kevin C.] Albany Med Coll, USA, Albany, NY 12208 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2013 VL 121 IS 5 BP 1111 EP 1111 DI 10.1097/AOG.0b013e31828fff7e PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 139SU UT WOS:000318605400035 PM 23635759 ER PT J AU DeVine, JG AF DeVine, John G. TI Bone grafting techniques in idiopathic scoliosis: a confirmation that allograft is as good as autograft but dispels the purported pain associated with the iliac crest bone graft harvest SO SPINE JOURNAL LA English DT Editorial Material ID SITE MORBIDITY; SPINAL-FUSION; SURGERY; OUTCOMES C1 Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA. RP DeVine, JG (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM john-devine@comcast.net NR 11 TC 2 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD MAY PY 2013 VL 13 IS 5 BP 530 EP 531 DI 10.1016/j.spinee.2013.02.047 PG 2 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 144YI UT WOS:000318978300013 PM 23664557 ER PT J AU Wu, CC Chung, PW Aubry, S Munday, LB Arsenlis, A AF Wu, C. -C. Chung, P. W. Aubry, S. Munday, L. B. Arsenlis, A. TI The strength of binary junctions in hexagonal close-packed crystals SO ACTA MATERIALIA LA English DT Article DE Discrete dislocation dynamics; Strength; Yield surface; hcp Metals ID DISLOCATION JUNCTIONS; FOREST INTERACTIONS; FCC CRYSTALS; SLIP SYSTEMS; METALS; SIMULATIONS; DYNAMICS; STRESS; MECHANISMS; DENSITY AB A comparative study of non-coplanar binary dislocation junctions in magnesium (Mg) and beryllium (Be) is presented to examine the effects of elastic properties and active Burgers vectors on junction formation and destruction in hexagonal close-packed (hcp) crystals via discrete dislocation dynamics simulations. Two junction configurations formed at intersecting prismatic (01 (1) over bar0)/basal (0001) planes and type-II pyramidal ((2) over bar 112)/prismatic (01 (1) over bar0) planes are studied using Burgers vectors of varying magnitudes. The equilibrium junctions are created from two intersecting straight gliding dislocations, and their subsequent strengths are evaluated under uniform applied stresses. The relative junction strengths between Mg and Be are consistent with their relative elastic stiffness, i.e., the modulus of elasticity for Mg is approximately one order of magnitude smaller than that of Be, and their junction strengths are similarly one order of magnitude apart. In general, the yield surfaces for junctions in Be are larger than those in Mg after normalization with the respective elastic moduli and Poisson's ratios. All yield surfaces exhibit a strong symmetry. However, the size and shape of the yield surfaces depend on the slip systems, especially the active Burgers vectors. The yield surfaces of hcp crystals can resemble those of face-centered cubic or body-centered cubic crystals when the active Burgers vectors of the dislocations involved in the junction are of type < a >, namely < 11 (2) over bar0 >, and are distinct when Burgers vectors of different types are used: for instance, a type < a + c >, namely 1/3 < 11 (2) over bar(3) over bar >, interacting with a type < a >. It was also found that junctions with more edge part exhibit more elongated yield surfaces than those with more screw part, and slip systems involved with < a > Burgers vectors result in smaller yield surfaces. These results demonstrate that junction strengths for hcp crystals are largely determined by elastic properties and Burgers vectors. The work aims to assess the effects of intrinsic material properties and dislocation slip systems on the strength of different binary dislocation junctions for general hcp structures. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Wu, C. -C.; Chung, P. W.; Munday, L. B.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Aubry, S.; Arsenlis, A.] Lawrence Livermore Natl Lab, Condensed Matter & Mat Div, High Performance Computat Mat Sci & Chem Grp, Livermore, CA 94551 USA. RP Wu, CC (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. EM chi-chin.wu.ctr@mail.mil FU Oak Ridge Affiliated Universities (ORAU) in Maryland [W911QX-04-C-0129]; Army Research Laboratory (ARL) Enterprise for Multiscale Research of Materials; ARL Director's Research Initiative (DRI); US Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX This work was conducted through support from the Oak Ridge Affiliated Universities (ORAU) in Maryland under Contract No. W911QX-04-C-0129 at the US Army Research Laboratory, the Army Research Laboratory (ARL) Enterprise for Multiscale Research of Materials and the ARL Director's Research Initiative (DRI). Computing resources were provided by the Department of Defense (DoD) High Performance Supercomputing Resource Center (DSRC). This work was also performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344. The authors gratefully appreciate many valuable discussions with colleagues at ARL, including Kenneth A. Jones, Jaroslaw Knap, Joshua Crone and Kenneth Leiter. NR 45 TC 11 Z9 11 U1 2 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD MAY PY 2013 VL 61 IS 9 BP 3422 EP 3431 DI 10.1016/j.actamat.2013.02.033 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 138TS UT WOS:000318533500028 ER PT J AU Pennock, S Kim, D Mukai, S Kuhnle, M Chun, DW Matsubara, J Cui, J Ma, P Maberley, D Samad, A Van Geest, RJ Oberstein, SL Schlingemann, RO Kazlauskas, A AF Pennock, Steven Kim, David Mukai, Shizuo Kuhnle, Matthew Chun, Dal W. Matsubara, Joanne Cui, Jing Ma, Patrick Maberley, David Samad, Arif Van Geest, Robert J. Oberstein, Sarit L. Schlingemann, Reinier O. Kazlauskas, Andrius TI Ranibizumab Is a Potential Prophylaxis for Proliferative Vitreoretinopathy, a Nonangiogenic Blinding Disease SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID ENDOTHELIAL GROWTH-FACTOR; RETINAL-DETACHMENT; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; INTRAVITREAL BEVACIZUMAB; EPIRETINAL MEMBRANES; SIGNAL-TRANSDUCTION; EXPERIMENTAL-MODEL; FACTOR RECEPTOR; VITREOUS-HUMOR AB Proliferative vitreoretinopathy (PVR) exemplifies a disease that is difficult to predict, Lacks effective treatment options, and substantially reduces the quality of life of an individual. Surgery to correct a rhegmatogenous retinal detachment fails primarily because of PVR. Likely mediators of PVR are growth factors in vitreous, which stimulate cells within and behind the retina as an inevitable consequence of a breached retina. Three classes of growth factors [vascular endothelial growth factor A (VEGF-A), platelet-derived growth factors (PDGFs), and non-PDGFs (growth factors outside of the PDGF family)] are relevant to PVR pathogenesis because they act on PDGF receptor alpha, which is required for experimental PVR and is associated with this disease in humans. We discovered that ranibizumab (a clinically approved agent that neutralizes VEGF-A) reduced the bioactivity of vitreous from patients and experimental animals with PVR, and protected rabbits from developing disease. The apparent mechanism of ranibizumab action involved derepressing PDGFs, which, at the concentrations present in PVR vitreous, inhibited non-PDGF-mediated activation of PDGF receptor alpha. These predinical findings suggest that available approaches to neutralize VEGF-A are prophylactic for PVR, and that anti-VEGF-based therapies may be effective for managing more than angiogenesis- and edema-driven pathological conditions. C1 [Pennock, Steven; Kim, David; Mukai, Shizuo; Kazlauskas, Andrius] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Schepens Eye Res Inst, Boston, MA 02114 USA. [Pennock, Steven; Kim, David; Mukai, Shizuo; Kazlauskas, Andrius] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA. [Kuhnle, Matthew; Chun, Dal W.] Walter Reed Army Med Ctr, Dept Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Matsubara, Joanne; Cui, Jing; Ma, Patrick; Maberley, David] Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC V5Z 1M9, Canada. [Samad, Arif] Dalhousie Univ, Dept Ophthalmol & Visual Sci, Halifax, NS, Canada. [Van Geest, Robert J.; Oberstein, Sarit L.; Schlingemann, Reinier O.] Univ Amsterdam, Acad Med Ctr, Med Retina Unit, NL-1105 AZ Amsterdam, Netherlands. [Van Geest, Robert J.; Oberstein, Sarit L.; Schlingemann, Reinier O.] Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, Ocular Angiogenesis Grp, NL-1105 AZ Amsterdam, Netherlands. RP Kazlauskas, A (reprint author), Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst,Massachusetts Eye & Ear Inf, 20 Staniford St, Boston, MA 02114 USA. EM andrius_kazlauskas@meei.harvard.edu FU Department of Defense [WB1XWH-10-1-0392]; NIH [EY012509]; Canadian Institutes of Health Research (CIHR); Mukai Fund; CIHR [IAO 77736, MOP 97806]; Massachusetts Eye and Ear Infirmary (Boston) FX Supported by Department of Defense grant WB1XWH-10-1-0392 and NIH grant EY012509 (A.K.), a Canadian Institutes of Health Research (CIHR) fellowship (S.P.), Mukai Fund and Massachusetts Eye and Ear Infirmary (Boston) gifts (S.M.), and CIHR grants IAO 77736 and MOP 97806 (J.M. and J.C.). NR 62 TC 15 Z9 15 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD MAY PY 2013 VL 182 IS 5 BP 1659 EP 1670 DI 10.1016/j.ajpath.2013.01.052 PG 12 WC Pathology SC Pathology GA 138TY UT WOS:000318534100021 PM 23582767 ER PT J AU McKinney, C Elfendahl, M McMaster, HR AF McKinney, Chris Elfendahl, Mark McMaster, H. R. TI Why the US Army Needs Armor The Case for a Balanced Force SO FOREIGN AFFAIRS LA English DT Article C1 [McKinney, Chris; Elfendahl, Mark; McMaster, H. R.] USA, Washington, DC 20310 USA. [Elfendahl, Mark] Joint Adv Warfighting Sch, Norfolk, VA USA. [McMaster, H. R.] Maneuver Ctr Excellence, Ft Benning, GA USA. RP McKinney, C (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COUNCIL FOREIGN RELAT IONS INC PI NEW YORK PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD MAY-JUN PY 2013 VL 92 IS 3 BP 129 EP 136 PG 8 WC International Relations SC International Relations GA 145NP UT WOS:000319024000013 ER PT J AU Smits, KM Cihan, A Sakaki, T Howington, SE Peters, JF Illangasekare, TH AF Smits, Kathleen M. Cihan, Abdullah Sakaki, Toshihiro Howington, Stacy E. Peters, John F. Illangasekare, Tissa H. TI Soil Moisture and Thermal Behavior in the Vicinity of Buried Objects Affecting Remote Sensing Detection: Experimental and Modeling Investigation SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Environmental factors; geoscience and remote sensing; land surface; landmine detection; soil moisture ID IN-FIELD SOILS; LANDMINE DETECTION; WATER-CONTENT; DIURNAL CYCLE; BARE SOILS; MINES; TEMPERATURE; CONDUCTIVITY; SIGNATURES; DISTRIBUTIONS AB Improvements in buried mine detection using remote sensing technology rest on understanding the effects on sensor response of spatial and temporal variability created by soil and environmental conditions. However, research efforts on mine detection have generally emphasized sensor development, while less effort has been made to evaluate the effects of the environmental conditions in which the mines are placed. If the processes governing moisture and temperature distribution near the ground surface can be captured, sensor development and deployment can be more realistically tailored to particular operational scenarios and technologies. The objective of this study is to investigate the effects of the soil environment on landmine detection by studying the influence of the thermal boundary conditions at the land-atmosphere interface and the buried objects themselves on the spatial and temporal distribution of soil moisture around shallow-buried objects. Two separate large tank experiments were performed with buried objects with different thermal properties. Experimental results were compared to results from a fully coupled heat and mass transfer numerical model. Comparison of experimental and numerical results suggests that the vapor enhancement factor used to adjust the vapor diffusive flux described based on Fick's law is not necessary under dry soil conditions. Data and simulations from this study show that the thermal signature of a buried object depends on the complex interaction among a soil's water content and its thermal and hydraulic properties. Simulated thermal and saturation contrasts were generally very different for a buried landmine than for other buried objects. C1 [Smits, Kathleen M.; Sakaki, Toshihiro; Illangasekare, Tissa H.] Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc, Golden, CO 80401 USA. [Cihan, Abdullah] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA. [Howington, Stacy E.; Peters, John F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Smits, KM (reprint author), Colorado Sch Mines, Ctr Expt Study Subsurface Environm Proc, Golden, CO 80401 USA. RI Smits, Kathleen/F-8465-2014; Cihan, Abdullah/D-3704-2015 FU U. S. Army Research Office [W911NF-04-1-0169]; Engineering Research and Development Center; Army Research Office FX This work was supported by the U. S. Army Research Office under Award W911NF-04-1-0169 and the Engineering Research and Development Center.; The authors acknowledge R. Harmon from the Army Research Office for financial support and technical contributions. NR 64 TC 5 Z9 5 U1 1 U2 32 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAY PY 2013 VL 51 IS 5 BP 2675 EP 2688 DI 10.1109/TGRS.2012.2214485 PN 1 PG 14 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 137IJ UT WOS:000318428700016 ER PT J AU Rose, R Kheirabadi, BS Klemcke, HG AF Rose, Rajiv Kheirabadi, Bijan S. Klemcke, Harold G. TI Arterial blood gases, electrolytes, and metabolic indices associated with hemorrhagic shock: inter- and intrainbred rat strain variation SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE intrainbred strain variation; intraclass correlation coefficient; hemorrhage; arterial blood gases; Pa-CO2; oxygen content; blood electrolytes ID OXYGEN-TRANSPORT RESPONSES; ACID-BASE; TISSUE HYPOXIA; MYOCARDIAL-ISCHEMIA; TRAUMA PATIENTS; SURVIVAL-TIME; GLUCOSE; POTASSIUM; PLASMA; DEATH AB We have previously shown interstrain variation (indicating a genetic basis), and intrastrain variation in survival time after hemorrhage (STaH) among inbred rat strains. To assist in understanding physiological mechanisms associated with STaH, we analyzed various arterial blood measures (ABM; pH, Pa-CO2, oxygen content, sodium, potassium, glucose, bicarbonate, base excess, total CO2, and ionized calcium) in inbred rats. Rats from five inbred strains (n = 8-10/strain) were catheterized and, similar to 24 h later, subjected to a conscious, controlled, 47% hemorrhage. ABM were measured at the start (initial) and end (final) of hemorrhage. Inter- and intrainbred strain variations of ABM were quantified and compared, and correlations of ABM with STaH were determined. All final ABM values and some initial ABM values were different among strains. Most ABM changed (Delta) during hemorrhage, and these changes differed among strains (P <0.03). Some strain-dependent correlations (r >= 0.7; P <= 0.05) existed between Delta ABM and STaH (e.g., BN/Mcwi, Delta K+, r = -0.84). Dark Agouti rats (longest STaH) had the smallest Delta Pa-CO2, Delta HCO3-, and Delta base excess, and the highest final glucose. High coefficients of variation (CVs, > 10%), strain-specific CVs, and low intraclass correlation coefficients (r(I) < 0.5) defined the large intrastrain ABM variation that exceeded interstrain variation for most ABM. These results suggest that some ABM (K+, Pa-CO2, glucose, oxygen content) could predict subsequent STaH in an inbred rat strain-dependent manner. We speculate that whereas genetic differences may be responsible for interstrain variation, individual-specific epigenetic processes (e. g., DNA methylation) may be partly responsible for both inter- and intrastrain ABM variation. C1 [Rose, Rajiv; Kheirabadi, Bijan S.; Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3650 Chamber Pass, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil FU U.S. Army Medical Research and Materiel Command FX Support for this study was provided by the U.S. Army Medical Research and Materiel Command. NR 80 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2013 VL 114 IS 9 BP 1165 EP 1173 DI 10.1152/japplphysiol.01293.2012 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 138YG UT WOS:000318547200006 PM 23471949 ER PT J AU Stewart, IJ Cotant, CL Tilley, MA Huzar, TF Aden, JK Snow, BD Gisler, C Kramer, KW Sherratt, JR Murray, CK Blackbourne, LH Renz, EM Chung, KK AF Stewart, Ian J. Cotant, Casey L. Tilley, Molly A. Huzar, Todd F. Aden, James K. Snow, Brian D. Gisler, Christopher Kramer, Keith W. Sherratt, Jesse R. Murray, Clinton K. Blackbourne, Lorne H. Renz, Evan M. Chung, Kevin K. TI Association of Rhabdomyolysis With Renal Outcomes and Mortality in Burn Patients SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ACUTE KIDNEY INJURY; INTENSIVE-CARE-UNIT; RIFLE CRITERIA; FAILURE; SEVERITY; THERAPY; FLUID AB The contribution of rhabdomyolysis to acute kidney injury (AKI) in the context of burn injury is poorly studied. We sought to determine the impact of rhabdomyolysis on AKI (defined by the AKI Network classification), renal replacement therapy (RRT), and death. Patients admitted to the burn unit at our institution were examined. Information on sex, age, presence of inhalation injury, electrical burn, percentage TBSA burned, percentage of full-thickness burns, Injury Severity Score, and peak creatine kinase (CK) were recorded. These variables were examined via multivariate logistic regression analysis against AKI Network stage, RRT, and death. Of 1973 consecutive admissions meeting the inclusion criteria, 525 met our eligibility criteria. Log peak CK was found to be correlated with any stage of AKI (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.36-2.16; P < .0001), moderate to severe AKI (OR, 2.09; 95% CI, 1.40-3.11; P = .0003), need for RRT (OR, 1.67; 95% CI, 1.16-2.40; P = .0057), and mortality (OR, 1.49; 95% CI, 1.01-2.20; P = .0441), after adjustment. Each 10-fold increase in peak CK was associated with a 70% increase in the odds of AKI, more than a 100% increase in the odds of moderate to severe AKI, a nearly 70% increase in the odds of RRT, and an almost 50% increase in the odds of mortality in patients with burn injury. (J Burn Care Res 2013;34:318-325) C1 [Stewart, Ian J.; Tilley, Molly A.; Snow, Brian D.; Kramer, Keith W.; Sherratt, Jesse R.; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. [Huzar, Todd F.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX USA. [Aden, James K.; Blackbourne, Lorne H.; Renz, Evan M.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gisler, Christopher] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX USA. [Renz, Evan M.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Stewart, IJ (reprint author), ATTN Nephrol, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU Department of Defense FX Supported by the Department of Defense. NR 30 TC 7 Z9 7 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2013 VL 34 IS 3 BP 318 EP 325 DI 10.1097/BCR.0b013e31825addbd PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 139XO UT WOS:000318618600017 PM 22955163 ER PT J AU Poda, AR Kennedy, AJ Cuddy, MF Bednar, AJ AF Poda, Aimee R. Kennedy, Alan J. Cuddy, Michael F. Bednar, Anthony J. TI Investigations of UV photolysis of PVP-capped silver nanoparticles in the presence and absence of dissolved organic carbon SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE Silver nanoparticles; Photolysis; Daphnia magna; Field flow fractionation; FFF-ICP-MS; Dissolved organic carbon; Toxicity; Environmental relevance ID ION-RELEASE KINETICS; ANTIBACTERIAL ACTIVITY; METALLIC NANOPARTICLES; ENVIRONMENTAL FATE; TOXICITY; WATER; MATTER; NANOMATERIALS; DISSOLUTION; EXPOSURE AB This study investigated the effect of UV irradiation on the characteristics and toxicity of 50 nm (nominal diameter) polyvinylpyrrolidone-capped silver nanoparticles (AgNPs) in the presence and absence of dissolved organic carbon (DOC). The photolysis resulted in a decrease in average particle size as measured by field flow fractionation interfaced with inductively coupled plasma mass spectrometry. The decrease in size was attributed to the photo-induced oxidation of the PVP and dissolution of metallic silver. Moreover, photolysis of the AgNPs in solutions containing DOC appeared to give rise to small nanoparticles (similar to 5 nm) formed via reduction of dissolved silver ions. These results were consistent with photolysis of AgNO3 solutions initially devoid of nanoparticles. Thus, the carbon-containing constituents of DOC serve as reducing agents for Ag+, primarily under conditions of UV irradiation. The standard zooplankton model, Daphnia magna, indicated that the toxicity of nanosilver was significantly reduced when the AgNPs have been exposed to UV light. Observed toxicity was further reduced when AgNPs in DOC-containing solutions were exposed to UV. These results suggest that environmentally relevant conditions such as DOC and UV light are important mitigating factors that mediate the aquatic toxicity of AgNPs. C1 [Poda, Aimee R.; Kennedy, Alan J.; Cuddy, Michael F.; Bednar, Anthony J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Cuddy, MF (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM aimee.r.poda@usace.army.mil; michael.cuddy@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 34 TC 9 Z9 9 U1 2 U2 88 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 J9 J NANOPART RES JI J. Nanopart. Res. PD MAY PY 2013 VL 15 IS 5 AR 1673 DI 10.1007/s11051-013-1673-7 PG 10 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 139BC UT WOS:000318555400071 ER PT J AU Swearingen, ME White, MJ Guertin, PJ Albert, DG Tunick, A AF Swearingen, Michelle E. White, Michael J. Guertin, Patrick J. Albert, Donald G. Tunick, Arnold TI Influence of a forest edge on acoustical propagation: Experimental results SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID IMPEDANCE MODELS; TREE BELTS; SOUND; ATTENUATION; PREDICT AB Acoustic propagation through a forest edge can produce complicated pressure time histories because of scattering from the trees and changes in the microclimate and ground parameters of the two regions. To better understand these effects, a field experiment was conducted to measure low-frequency acoustic pulses propagating in an open field, a forest, and passing through a forest edge in both directions. Waveforms measured in the open field were simple impulses with very low scattering, whereas waveforms at the edge and within the forest had stronger reverberations after the direct arrival. The direct wave pulse shapes increased in duration in accordance with the path length in the forest, which had an effective flow resistivity 1/2 to 1/3 that of the grassy open field. The measurements exhibit different rates of attenuation in the two regions, with relatively lower attenuation in the open field than higher rates in the forest. Decay of SEL transmitted into the forest was 4 dB more per tenfold distance than for outbound transmission. Stronger attenuation in the 1-2 kHz range occurs when propagating into the forest. While the measured meteorological profiles revealed three distinct micro-climates, meteorological effects are not sufficient to explain the apparent non-reciprocal propagation. C1 [Swearingen, Michelle E.; White, Michael J.; Guertin, Patrick J.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Albert, Donald G.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Tunick, Arnold] USA, Res Lab, Adelphi, MD 20783 USA. RP Swearingen, ME (reprint author), USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. EM michelle.e.swearingen@usace.army.mil FU U.S. Army Engineer Research and Development Center Environmental Quality/Technology and Installations Basic Research Program [AT23-06-54, BT25-12-94] FX The authors would like to thank CPT Keith Ferdon, Bill Brown, Tim Notch, CW2 Derek Lindberg, SSG Justin Piepenburg, and all of the personnel at Camp Ripley who provided test support and logistical assistance. The authors also thank Jeff Mifflin, Steve Decato, and Tim Onder for their assistance during field data collection. The authors also thank the anonymous reviewers for their comments. Funding support was provided by project AT23-06-54 and BT25-12-94, part of the U.S. Army Engineer Research and Development Center Environmental Quality/Technology and Installations Basic Research Program. (Distribution Statement A - Approved for Public Release; distribution unlimited.) NR 29 TC 3 Z9 3 U1 0 U2 13 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 2013 VL 133 IS 5 BP 2566 EP 2575 DI 10.1121/1.4799011 PN 1 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 139BH UT WOS:000318555900021 PM 23654365 ER PT J AU Nykaza, ET Hodgdon, KK Gaugler, T Krecker, P Luz, GA AF Nykaza, Edward T. Hodgdon, Kathleen K. Gaugler, Trent Krecker, Peg Luz, George A. TI On the relationship between blast noise complaints and community annoyance SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HUMAN RESPONSE; EXPOSURE; MODEL AB Military installations typically rely on noise complaints to indicate adverse noise environments and often restrict the firing of certain weapons to reduce the number of noise complaints. Using complaints in this manner may also imply that the absence of complaints is an indicator of low community annoyance. The relationship between individual complaints and general community annoyance, however, is currently not established, and it is unknown whether implementing restrictions in reaction to individual complaints is an appropriate or necessary way to reduce community annoyance. This paper looks at whether there are significant differences in reported annoyance to complaint-referenced blast events and general military noise annoyance between those who complain and their non-complaining neighbors. Those who complained were significantly more annoyed to both complaint-referenced blast events and general military noise in comparison to their non-complaining neighbors. The implications of these findings are discussed in terms of range management. [http://dx.doi.org/10.1121/1.4795781] C1 [Nykaza, Edward T.] USA, Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Hodgdon, Kathleen K.; Gaugler, Trent] Penn State Univ, State Coll, PA 16804 USA. [Krecker, Peg] Tetra Tech, Madison, WI 53719 USA. RP Nykaza, ET (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM edward.t.nykaza@erdc.dren.mil OI Gaugler, Trent/0000-0002-8006-9184 FU Strategic Environmental Research and Development Program (SERDP); Engineer Research and Development Center (ERDC) FX This work has been funded by the Strategic Environmental Research and Development Program (SERDP) and the Engineer Research and Development Center (ERDC). The authors would like to thank Larry Pater, Sandy Fidell, and Paul Schomer for their input on the original study design, and the two anonymous reviewers for their constructive comments. The opinions expressed in this document are solely those of the authors and are not to be construed as an official Department of the Army position unless so designated by other authorized documents. [Distribution Statement - A (Approved for public release; distribution unlimited)] NR 46 TC 4 Z9 4 U1 0 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 2013 VL 133 IS 5 BP 2690 EP 2698 DI 10.1121/1.4795781 PN 1 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 139BH UT WOS:000318555900033 PM 23654377 ER PT J AU Jang, SG Audus, DJ Klinger, D Krogstad, DV Kim, BJ Cameron, A Kim, SW Delaney, KT Hur, SM Killops, KL Fredrickson, GH Kramer, EJ Hawker, CJ AF Jang, Se Gyu Audus, Debra J. Klinger, Daniel Krogstad, Daniel V. Kim, Bumjoon J. Cameron, Alexandre Kim, Sang-Woo Delaney, Kris T. Hur, Su-Mi Killops, Kato L. Fredrickson, Glenn H. Kramer, Edward J. Hawker, Craig J. TI Striped, Ellipsoidal Particles by Controlled Assembly of Diblock Copolymers SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID BLOCK-COPOLYMER; THIN-FILMS; GOLD NANOPARTICLES; MORPHOLOGICAL TRANSFORMATION; SEPARATED STRUCTURES; SURFACE-CHEMISTRY; POLYMER PARTICLES; CONFINEMENT; LOCATION; ROUTE AB Control of interfacial interactions leads to a dramatic change in shape and morphology for particles based on poly(styrene-b-2-vinylpyridine) diblock copolymers Key to these changes is the addition of Au-based surfactant nano particles (SNPs) which are adsorbed at the interface between block copolymer-containing emulsion droplets and the surrounding amphiphilic surfactant to afford asymmetric, ellipsoid particles The mechanism of formation for these novel nanostructures was investigated by systematically varying the volume fraction of SNPs, with the results showing the critical nature that the segregation of SNPs to specific interfaces plays in controlling structure. A theoretical description of the system allows the site distribution and aspect ratio of the asymmetric block copolymer colloidal particles to be correlated with the experimental results. C1 [Jang, Se Gyu; Audus, Debra J.; Klinger, Daniel; Krogstad, Daniel V.; Cameron, Alexandre; Kim, Sang-Woo; Delaney, Kris T.; Hur, Su-Mi; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Audus, Debra J.; Fredrickson, Glenn H.; Kramer, Edward J.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Krogstad, Daniel V.; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Hawker, Craig J.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Kim, Bumjoon J.] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea. [Killops, Kato L.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Fredrickson, GH (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. EM ghf@mrl.ucsb.edu; edkramer@mrl.ucsb.edu; hawker@mrl.ucsb.edu RI Kim, Bumjoon J./C-1714-2011; Delaney, Kris/D-4324-2011 OI Delaney, Kris/0000-0003-0356-1391 FU MRSEC Program of the National Science Foundation (NSF) [DMR-1121053]; Institute for Collaborative Biotechnologies through the U.S. Army Research Office [W911NF-09-D-0001]; CNSI-MRL Center for Scientific Computing [DMR-1121053, CNS-0960316] FX This work was supported by the MRSEC Program of the National Science Foundation (NSF) under Award DMR-1121053 (D.J.A., D.V.K., A.C., S.-W.K., K.T.D., S.H., E.J.K.) and by the Institute for Collaborative Biotechnologies through the U.S. Army Research Office (Contract W911NF-09-D-0001) (S.G.J., K.L.K., D.K., G.H.F., C.J.H.). We also acknowledge facilities support from the NSF-funded Materials Research Facilities Network (www.mrfn.org) and the CNSI-MRL Center for Scientific Computing (Grants DMR-1121053 and CNS-0960316). NR 72 TC 66 Z9 67 U1 23 U2 267 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD MAY 1 PY 2013 VL 135 IS 17 BP 6649 EP 6657 DI 10.1021/ja4019447 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA 137WO UT WOS:000318469100042 PM 23594106 ER PT J AU Watson, JDB Morrison, JJ McNamee, IL Evans, TW Rasmussen, TE AF Watson, J. Devin B. Morrison, Jonathan J. McNamee, Irma L. Evans, Thomas W. Rasmussen, Todd E. TI Expanded Polytetrafluoroethylene (ePTFE) Versus Autologous Vein as a Conduit for Vascular Reconstruction in Modern Combat Casualty Care SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery (SVS) CY MAY 30-JUN 01, 2013 CL San Francisco, CA SP Soc Vasc Surg (SVS) C1 [Watson, J. Devin B.] San Antonio Mil Med Ctr, San Antonio, TX USA. [McNamee, Irma L.; Evans, Thomas W.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. NR 0 TC 0 Z9 0 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD MAY PY 2013 VL 57 IS 5 SU S BP 11S EP 11S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 140VV UT WOS:000318685300017 ER PT J AU McCown, M Alleman, A Sayler, K Chandrashekar, R Thatcher, B Tyrrell, P Stillman, B Beall, M Barbet, A AF McCown, M. Alleman, A. Sayler, K. Chandrashekar, R. Thatcher, B. Tyrrell, P. Stillman, B. Beall, M. Barbet, A. TI SURVEILLANCE FOR TICK-BORNE PATHOGENS IN MILITARY WORKING DOGS, SHELTER ANIMALS AND PET POPULATIONS IN COLOMBIA SO JOURNAL OF VETERINARY INTERNAL MEDICINE LA English DT Meeting Abstract C1 [McCown, M.] USA, Vet Corps, Gainesville, FL USA. [Alleman, A.; Sayler, K.; Barbet, A.] Univ Florida, Coll Vet Med, Gainesville, FL USA. [Chandrashekar, R.; Thatcher, B.; Tyrrell, P.; Stillman, B.; Beall, M.] IDEXX Labs, Westbrook, ME USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0891-6640 J9 J VET INTERN MED JI J. Vet. Intern. Med. PD MAY-JUN PY 2013 VL 27 IS 3 BP 722 EP 723 PG 2 WC Veterinary Sciences SC Veterinary Sciences GA 140MO UT WOS:000318658400338 ER PT J AU Hamilton, JB Moore, AD Johnson, KA Koenig, HG AF Hamilton, Jill B. Moore, Angelo D. Johnson, Khishaana A. Koenig, Harold G. TI Reading The Bible for Guidance, Comfort, and Strength During Stressful Life Events SO NURSING RESEARCH LA English DT Article DE mental health; religion; spirituality; stress and coping ID QUALITATIVE CONTENT-ANALYSIS; AFRICAN-AMERICANS; OLDER-ADULTS; OUTCOMES AB Background: The use of religious practices to promote mental health among African Americans is well documented. African Americans are more likely to report strong religious affiliations and to use religion over prescribed medications for mental health problems. However, few studies have explored how African Americans use religious practices in response to stressful life events. Objective: The aim of this study is to examine how African American women and men find comfort in using scripture passages from The Bible. Methods: Fifty-four African American adults residing in the Southeastern United States participated in a qualitative descriptive study using open-ended semistructured interviews. Participants were asked to describe their use of scripture passages from The Bible and the personal meanings associated with these scriptures in the context of a family death or life-threatening illness. Results: These participants used scripture passages categorized as God as Protector, God as Beneficent, Praise and Thanksgiving, God as Healer, Memory of Forefathers, Prayers to God, and Life after Death. Few gender differences were noted. However, women were more likely to use scripture passages of God as Protector and Life after Death, whereas men were more likely to use God as Beneficent and God as Healer. Discussion: The religious practice of reading scripture passages from The Bible is a mental health-promoting strategy used during stressful life events. The findings of this study have practical uses for nurses and can be used to inform acceptable and sensitive approaches in addressing mental health issues and spiritual care needs in African American patients. C1 [Hamilton, Jill B.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Moore, Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA. [Johnson, Khishaana A.] N Carolina State Univ, Raleigh, NC 27695 USA. [Koenig, Harold G.] Duke Univ, Med Ctr, Ctr Spiritual Theol & Hlth, Durham, NC USA. [Koenig, Harold G.] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia. RP Hamilton, JB (reprint author), Univ N Carolina, Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA. EM jhamilto@email.unc.edu RI Koenig, Harold/F-7379-2011 NR 22 TC 4 Z9 4 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-6562 J9 NURS RES JI Nurs. Res. PD MAY-JUN PY 2013 VL 62 IS 3 BP 178 EP 184 DI 10.1097/NNR.0b013e31828fc816 PG 7 WC Nursing SC Nursing GA 138ZJ UT WOS:000318550700005 PM 23636344 ER PT J AU Lundy, JB AF Lundy, Jonathan B. TI Commentary on "Predictors of Failed Primary Abdominal Closure in the Trauma Patient with an Open Abdomen" SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material ID FASCIAL APPROXIMATION C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Lundy, JB (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Jonathan.lundy1@amedd.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAY PY 2013 VL 106 IS 5 BP 332 EP 333 DI 10.1097/SMJ.0b013e318292440f PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 138YH UT WOS:000318547300010 PM 23644643 ER PT J AU Ismayilova, R Mody, R Abdullayev, R Amirova, K Jabbarova, L Ustun, N Jahanov, M Nasirova, E Powers, M Rivard, R Hepburn, M Bautista, CT AF Ismayilova, Rita Mody, Rupal Abdullayev, Rakif Amirova, Kamala Jabbarova, Latafat Ustun, Narmin Jahanov, Musa Nasirova, Emilya Powers, Marilyn Rivard, Robert Hepburn, Matthew Bautista, Christian T. TI Short Report: Screening of Household Family Members of Brucellosis Cases and Neighboring Community Members in Azerbaijan SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID REEMERGING ZOONOSIS; RISK-FACTORS AB Brucellosis is an endemic zoonotic disease in Azerbaijan. The first human brucellosis case reported in 1922 was in Pardabil village of a region currently named Shabran. Household members of brucellosis index cases are a population at risk for brucellosis infection. The purpose of this study was to determine the rate of seropositivity of brucellosis among household and neighboring community members of brucellosis index cases in Azerbaijan. Twenty-one household members of 8 index brucellosis cases and 27 community neighbors were serologically tested for evidence of exposure by the serum agglutination test. Of these, the brucellosis seropositivity rate was 9.5% and 7.4%, respectively. Screening of household members of index cases and individuals who live in proximity to infected household members is a practical approach to increase the detection of brucellosis exposure. C1 Republican Antiplague Stn, Baku, Azerbaijan. [Mody, Rupal; Nasirova, Emilya; Powers, Marilyn; Rivard, Robert; Hepburn, Matthew] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ismayilova, Rita; Abdullayev, Rakif; Amirova, Kamala; Jabbarova, Latafat; Ustun, Narmin; Jahanov, Musa] Azerbaijan Republican Antiplague Stn, Baku, Azerbaijan. RP Bautista, CT (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM rita2202@rambler.ru; rupal.mody@us.army.mil; doktor1952@rambler.ru; kamalaemirova@mail.ru; latafat.jabbarova@gmail.com; ustunnermin@yahoo.com; musa.jahanov@abta.az; Emilya.Nasirova@konsis.az; Marilyn.Powers@us.army.mil; Robert.G.Rivard@us.army.mil; matthew.hepburn@yahoo.com; Christian.Bautista@us.army.mil FU Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program (CBEP) FX The Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program (CBEP) funded this study. NR 11 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2013 VL 88 IS 5 BP 929 EP 931 DI 10.4269/ajtmh.12-0381 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 136WR UT WOS:000318394600020 PM 23478582 ER PT J AU Kobayashi, N Pietropaolo, JA Melby, JA AF Kobayashi, Nobuhisa Pietropaolo, Jill A. Melby, Jeffrey A. TI Wave Transformation and Runup on Dikes and Gentle Slopes SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Wave breaking; beach; surf zone; wave setup; swash; wave runup; wave overtopping; dike ID NATURAL BEACH; SWASH; PREDICTIONS; VELOCITIES; SETUP; MODEL AB Coastal flood-risk mapping requires the prediction of wave runup and overtopping of dikes and beaches. The cross-shore numerical model CSHORE is adjusted to predict irregular wave runup on impermeable dikes. The model is compared with 137 wave runup tests and 97 wave overtopping tests. The seaward boundary of the computation is taken at the location where wave setup is negligible. The spectral period and peak period at this boundary location are specified as input. The model predicts the measured cross-shore variation of the spectral significant wave height on the barred and sloping beaches in front of the dikes. The measured 2% and 1% exceedence runup heights are predicted within errors of about 20% for the spectral period used as input to CSHORE. The model predicts the threshold of wave overtopping, but the minor wave overtopping rates can be predicted only within a factor of 10. The model is also compared with 120 tests for wave runup on gentle uniform slopes as well as wave runup data on natural beaches in order to assess the utility of the numerical model for coastal flood-risk mapping on sand beaches. C1 [Kobayashi, Nobuhisa; Pietropaolo, Jill A.] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Melby, Jeffrey A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. EM nk@udel.edu FU U.S. Army Corps of Engineers, Coastal and Hydraulics Laboratory [W912HZ-10-P-0234, W912HZ-11-P-0173] FX This study was supported by the U.S. Army Corps of Engineers, Coastal and Hydraulics Laboratory under Contract Nos. W912HZ-10-P-0234 and W912HZ-11-P-0173. We would like to thank Marcel van Gent for providing his reports. NR 24 TC 2 Z9 2 U1 2 U2 6 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD MAY PY 2013 VL 29 IS 3 BP 615 EP 623 DI 10.2112/JCOASTRES-D-11-00216.1 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 137SI UT WOS:000318457300011 ER PT J AU Goodin, C AF Goodin, Christopher TI Analytic expressions for the black-sky and white-sky albedos of the cosine lobe model SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article AB The cosine lobe model is a bidirectional reflectance distribution function (BRDF) that is commonly used in computer graphics to model specular reflections. The model is both simple and physically plausible, but physical quantities such as albedo have not been related to the parameterization of the model. In this paper, analytic expressions for calculating the black-sky and white-sky albedos from the cosine lobe BRDF model with integer exponents will be derived, to the author's knowledge for the first time. These expressions for albedo can be used to place constraints on physics-based simulations of radiative transfer such as high-fidelity ray-tracing simulations. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Goodin, C (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM christopher.t.goodin@erdc.dren.mil NR 15 TC 0 Z9 0 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAY PY 2013 VL 30 IS 5 BP 854 EP 858 DI 10.1364/JOSAA.30.000854 PG 5 WC Optics SC Optics GA 138FL UT WOS:000318494100006 PM 23695315 ER PT J AU Pratt, KA Custard, KD Shepson, PB Douglas, TA Pohler, D General, S Zielcke, J Simpson, WR Platt, U Tanner, DJ Huey, LG Carlsen, M Stirm, BH AF Pratt, Kerri A. Custard, Kyle D. Shepson, Paul B. Douglas, Thomas A. Poehler, Denis General, Stephan Zielcke, Johannes Simpson, William R. Platt, Ulrich Tanner, David J. Huey, L. Gregory Carlsen, Mark Stirm, Brian H. TI Photochemical production of molecular bromine in Arctic surface snowpacks SO NATURE GEOSCIENCE LA English DT Article ID OZONE DESTRUCTION; SEA-SALT; BOUNDARY-LAYER; POLAR SUNRISE; ICE; DEPLETION; FROZEN; SNOW; TROPOSPHERE; RELEASE AB Following the springtime polar sunrise, ozone concentrations in the lower troposphere episodically decline to near-zero levels(1). These ozone depletion events are initiated by an increase in reactive bromine levels in the atmosphere(2-5). Under these conditions, the oxidative capacity of the Arctic troposphere is altered, leading to the removal of numerous transported trace gas pollutants, including mercury(6). However, the sources and mechanisms leading to increased atmospheric reactive bromine levels have remained uncertain, limiting simulations of Arctic atmospheric chemistry with the rapidly transforming sea-ice landscape(7,8). Here, we examine the potential for molecular bromine production in various samples of saline snow and sea ice, in the presence and absence of sunlight and ozone, in an outdoor snow chamber in Alaska. Molecular bromine was detected only on exposure of surface snow ( collected above tundra and first-year sea ice) to sunlight. This suggests that the oxidation of bromide is facilitated by a photochemical mechanism, which was most efficient for more acidic samples characterized by enhanced bromide to chloride ratios. Molecular bromine concentrations increased significantly when the snow was exposed to ozone, consistent with an interstitial air amplification mechanism. Aircraft-based observations confirm that bromine oxide levels were enhanced near the snow surface. We suggest that the photochemical production of molecular bromine in surface snow serves as a major source of reactive bromine, which leads to the episodic depletion of tropospheric ozone in the Arctic springtime. C1 [Pratt, Kerri A.; Custard, Kyle D.; Shepson, Paul B.; Carlsen, Mark] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. [Shepson, Paul B.] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47907 USA. [Shepson, Paul B.] Purdue Univ, Purdue Climate Change Res Ctr, W Lafayette, IN 47907 USA. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Poehler, Denis; General, Stephan; Zielcke, Johannes; Platt, Ulrich] Heidelberg Univ, Inst Environm Phys, D-69117 Heidelberg, Germany. [Simpson, William R.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Simpson, William R.] Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK 99775 USA. [Tanner, David J.; Huey, L. Gregory] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Stirm, Brian H.] Purdue Univ, Dept Aviat Technol, W Lafayette, IN 47907 USA. RP Pratt, KA (reprint author), Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. EM kapratt@purdue.edu RI Pratt, Kerri/F-8025-2010; Simpson, William/I-2859-2014 OI Pratt, Kerri/0000-0003-4707-2290; Simpson, William/0000-0002-8596-7290 FU National Science Foundation Office of Polar Programs [ARC-1107695]; National Aeronautics and Space Administration (NASA) Cryospheric Sciences Program as a part of the NASA Interdisciplinary Research on Arctic Sea Ice and Tropospheric Chemical Change [09-IDS09-31]; National Science Foundation Postdoctoral Fellowship in Polar Regions Research FX Financial support was provided by the National Science Foundation Office of Polar Programs (ARC-1107695) and the National Aeronautics and Space Administration (NASA) Cryospheric Sciences Program as a part of the NASA Interdisciplinary Research on Arctic Sea Ice and Tropospheric Chemical Change (09-IDS09-31). K.A.P. is supported by a National Science Foundation Postdoctoral Fellowship in Polar Regions Research. S. V. Nghiem is thanked for BROMEX organization. The MODIS image in Fig. 3 was provided by the NASA Rapid Response MODIS Subset in support of BROMEX. R. Replogle (Purdue University) is thanked for construction of the snow chamber. Solar radiation data were acquired by and obtained from the NOAA/ESRL/GMD Solar Radiation group. We are grateful to UMIAQ and CH2M Hill Polar Services for field logistical assistance. M. O. L. Cambaliza and D. Caulton (Purdue University) are thanked for aircraft attitude data used in the DOAS analysis. E. Boone (Purdue University) is thanked for aerosol data analysis. M. Sturm (CRREL) is thanked for chamber design advice. J. W. Halfacre (Purdue University) is thanked for calibration of the ozone monitor. R. Lieb-Lappen (Dartmouth University) is thanked for field discussions. This is publication 1241 of the Purdue Climate Change Research Center. NR 30 TC 45 Z9 46 U1 28 U2 124 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1752-0894 J9 NAT GEOSCI JI Nat. Geosci. PD MAY PY 2013 VL 6 IS 5 BP 351 EP 356 DI 10.1038/NGEO1779 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 134QA UT WOS:000318227000013 ER PT J AU Schumacher, PD Doyle, JL Schenk, JO Clark, SB AF Schumacher, Paul D. Doyle, Jamie L. Schenk, James O. Clark, Sue B. TI Electroanalytical chemistry of lanthanides and actinides SO REVIEWS IN ANALYTICAL CHEMISTRY LA English DT Article DE electrochemistry; electrodes; f-elements; plutonium; pre-concentration ID CARBON-PASTE ELECTRODE; ADSORPTIVE STRIPPING VOLTAMMETRY; CONTINUOUS CYCLIC VOLTAMMETRY; ION-EXCHANGE CHROMATOGRAPHY; MERCURY FILM ELECTRODES; AQUEOUS-SOLUTION; ELECTROCHEMICAL PROPERTIES; NONAQUEOUS MEDIA; ORGANIC-SOLVENTS; GLASSY-CARBON AB The electrochemical properties of lanthanides (Ln) and actinides (An) are reviewed. This review summarizes papers from 1986 to 2011 with a primary focus on the electrochemical and redox properties of Ln/An elements in aqueous solution and their responses to a variety of electrode materials including Hg, Hg films, solid electrodes, modified carbon paste, and microelectrodes. A section is also devoted to the electrochemical properties and responses of Ln and An in nonaqueous and mixed solvent systems. C1 [Schumacher, Paul D.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Doyle, Jamie L.; Schenk, James O.; Clark, Sue B.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA. RP Clark, SB (reprint author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA. EM s_clark@wsu.edu FU Washington State University; Academic Research Initiative of the Joint Domestic Nuclear Detection Office, Department of Homeland Security; National Science Foundation [ECCS-0833548, DN-077-ARI-03302]; US Department of Energy, Office of Science, Heavy Elements Program [DE-SC-0004102] FX P.D.S. acknowledges the support of the US Army while in residence at Washington State University. All the authors acknowledge funding from the Academic Research Initiative of the Joint Domestic Nuclear Detection Office, Department of Homeland Security, and the National Science Foundation, for funding under grant numbers ECCS-0833548 and DN-077-ARI-03302. In addition, S.B.C. acknowledges support from the US Department of Energy, Office of Science, Heavy Elements Program, grant number DE-SC-0004102. We also gratefully acknowledge two reviewers whose constructive comments helped us to improve this manuscript significantly. NR 83 TC 1 Z9 1 U1 4 U2 83 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0793-0135 J9 REV ANAL CHEM JI Rev. Anal. Chem. PD MAY PY 2013 VL 32 IS 2 BP 159 EP 171 DI 10.1515/revac-2012-0032 PG 13 WC Chemistry, Analytical SC Chemistry GA 137BA UT WOS:000318408500006 ER PT J AU Tannenbaum, LV Gulsby, WD Zobel, SS Miller, KV AF Tannenbaum, Lawrence V. Gulsby, William D. Zobel, Shaina S. Miller, Karl V. TI Where Deer Roam: Chronic Yet Acute Site Exposures Preclude Ecological Risk Assessment SO RISK ANALYSIS LA English DT Article DE Deer; ecological risk assessment; global positioning system technology; spatial relevance AB Global positioning system (GPS) technology has made possible the detailed tracking of the spatial movements of wildlife. Using GPS tracking collars placed on female white-tailed deer (Odocoileus virginianus) over a protracted period, we illustrate that this species is spatially irrelevant for consideration in ecological risk assessments (ERAs) for commonly assessed contaminated sites. Specifically, deer movements do not allow for a sufficiency of chemical exposures to occur such that toxicological endpoints would be triggered. Deer are spatially irrelevant not only because their home ranges and overall utilized areas dwarf prototypical hazardous waste sites. They are also inappropriate for assessment because they only minimally contact reasonably sized preferred locations, this while demonstrating a confounding high degree of site affinity for them. Our spatial movements analysis suggests that deer introduce the ERA novelty of a species displaying elements of both chronic and acute site exposure. We further suggest that other large commonly assessed high-profile mammals could also be found to be spatially irrelevant for ERAs were they to submit to the GPS tracking and subsequent data analysis we performed for the deer. Recognizing that certain receptors need not be considered in ERAs can help to simplify the ERA process. C1 [Tannenbaum, Lawrence V.; Zobel, Shaina S.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Gulsby, William D.; Miller, Karl V.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. RP Tannenbaum, LV (reprint author), USA, Environm Hlth Risk Assessment Program, Inst Publ Hlth, Publ Hlth Command,MCHB IP REH,APG EA, Bldg 1675, Aberdeen Proving Ground, MD 21010 USA. EM larry.tannenbaum@us.army.mil FU U.S. Army Environmental Command FX This work was supported by funds provided by the U.S. Army Environmental Command (Mr. Jim Daniel). The authors wish to thank Andrew Leitzer for his assistance with graphics, Jeffrey Leach and Sherri Hutchens for their helpful reviews, and Ms. Joyce Woods for her editing assistance. The opinions or assertions contained herein are the views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army Public Health Command, the U.S. Army, or the Department of Defense. NR 23 TC 0 Z9 0 U1 1 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD MAY PY 2013 VL 33 IS 5 BP 789 EP 799 DI 10.1111/j.1539-6924.2012.01890.x PG 11 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 137MT UT WOS:000318440700009 PM 22985105 ER PT J AU Costache, MC Vaughan, AD Qu, H Ducheyne, P Devore, DI AF Costache, M. C. Vaughan, A. D. Qu, H. Ducheyne, P. Devore, D. I. TI Tyrosine-derived polycarbonate-silica xerogel nanocomposites for controlled drug delivery SO ACTA BIOMATERIALIA LA English DT Article DE Nanocomposites; Silica xerogel; Tyrosine-derived co-polymers; Mechanical properties; Controlled drug release ID CONTROLLED-RELEASE; SOL-GEL; BONE; BIOMATERIALS; REGENERATION; SCAFFOLDS; DISCOVERY; COMBINATION; ANTIBIOTICS; VANCOMYCIN AB Biodegradable polymer ceramic composites offer significant potential advantages in biomedical applications where the properties of either polymers or ceramics alone are insufficient to meet performance requirements. Here we demonstrate the highly tunable mechanical and controlled drug delivery properties accessible with novel biodegradable nanocomposites prepared by non-covalent binding of silica xerogels and co-polymers of tyrosine-poly(ethylene glycol)-derived poly(ether carbonate). The Young's moduli of the nanocomposites exceed by factors of 5-20 times those of the co-polymers or of composites made with micron scale silica particles. Increasing the fraction of xerogel in the nanocomposites increases the glass transition temperature and the mechanical strength, but decreases the equilibrium water content, which are all indicative of strong non-covalent interfacial interactions between the copolymers and the silica nanoparticles. Sustained, tunable controlled release of both hydrophilic and hydrophobic therapeutic agents from the nanocomposites is demonstrated with two clinically significant drugs, rifampicin and bupivacaine. Bupivacaine exhibits an initial small burst release followed by slow release over the 7 day test period. Rifampicin release fits the diffusion-controlled Higuchi model and the amount released exceeds the dosage required for treatment of clinically challenging infections. These nanocomposites are thus attractive biomaterials for applications such as wound dressings, tissue engineering substrates and stents. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Costache, M. C.] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA. [Vaughan, A. D.; Devore, D. I.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Qu, H.; Ducheyne, P.] Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA. RP Devore, DI (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM david.devore@us.army.mil OI Qu, Haibo/0000-0003-4488-4277 FU US Army [W81XWH-07-1-0438]; US Army Institute of Surgical Research; New Jersey Center for Biomaterials, Rutgers University FX This work was supported in part by US Army contract no. W81XWH-07-1-0438. The US Army Medical Research Acquisition Activity, Fort Detrick, MD, was the awarding and administering acquisition office. The content of the manuscript does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. Support from the US Army Institute of Surgical Research and the New Jersey Center for Biomaterials, Rutgers University, is gratefully acknowledged. The authors thank Dr. Das Bolikal and Dr. Joachim Kohn of Rutgers University for their assistance. NR 55 TC 10 Z9 10 U1 4 U2 52 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 J9 ACTA BIOMATER JI Acta Biomater. PD MAY PY 2013 VL 9 IS 5 BP 6544 EP 6552 DI 10.1016/j.actbio.2013.01.034 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 134GY UT WOS:000318199600024 PM 23395749 ER PT J AU Mansi, IA Mortensen, EM Pugh, MJ Wegner, M Frei, CR AF Mansi, Ishak A. Mortensen, Eric M. Pugh, Mary J. Wegner, Michael Frei, Christopher R. TI Incidence of Musculoskeletal and Neoplastic Diseases in Patients on Statin Therapy: Results of a Retrospective Cohort Analysis SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Statin; Arthropathy; Neoplasm; Musculoskeletal; Side effects ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-DISEASE; GENERAL-PRACTICE; TENDON-RUPTURE; CANCER; RISK; TRIALS; METAANALYSIS; PAIN; ROSUVASTATIN AB Background: Because of their beneficial cardiovascular effects, several studies have recently advocated starting statins at a young age for primary prevention. However, some reports suggest that statin therapy may be associated with an increased incidence of musculoskeletal and neoplastic diseases. This study was conducted to investigate the incidence of various musculoskeletal and neoplastic diseases in statin users and nonusers. Methods: A retrospective cohort study of patients in the San Antonio Military Multi-Service Market during the period from October 1, 2003, to March 5, 2010, was conducted. The International Classification of Diseases, 9th edition, diagnosis codes between 2 cohort groups-statin users and nonusers-were compared. Statin users were those patients with at least one 3-month prescription for a statin in the fiscal year 2004. Nonusers were those patients who received a prescription-but not a statin-during the period of the study. Both groups were assessed for the development of musculoskeletal and neoplastic diseases in the following 4-year period (October 1, 2004, to September 30, 2009). Results: A total of 92,360 patients were identified: 12,980 statin users and 45,997 nonusers. After adjusting for age, sex and Charlson comorbidity index, statin users had significantly higher rates of osteoarthritis and arthropathy (odds ratio: 1.26; 95% confidence interval: 1.19-1.33), and dorsopathies, rheumatism and chondropathies (odds ratio: 1.20; 95% confidence interval: 1.12-1.27). Conclusions: In this retrospective analysis, statin use was associated with an increased incidence of musculoskeletal diseases, including arthropathy. Further studies are needed to provide physicians and their patients with adequate information regarding statin therapy, particularly if recommended for primary prevention in younger populations. C1 [Mansi, Ishak A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Brooke Army Med Ctr, San Antonio, TX 78229 USA. [Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Vet Affairs North Texas Hlth Care Syst, Dallas, TX 75390 USA. [Pugh, Mary J.] Univ Texas Hlth Sci Ctr San Antonio, Vet Affairs South Texas Hlth Care Syst, San Antonio, TX 78229 USA. [Wegner, Michael] Brooke Army Med Ctr, Business Operat Div, Ft Sam Houston, TX 78234 USA. [Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. [Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM Iishak.mansi@us.army.mil OI Mortensen, Eric/0000-0002-3880-5563 FU U.S. National Institutes of Health (NIH) in the form of an NIH KL2 career development award [RR025766]; AstraZeneca; Bristol-Myers Squibb; Elan; Forest; Ortho-McNeil Janssen; Pfizer FX C.R. Frei is supported by the U.S. National Institutes of Health (NIH) in the form of an NIH KL2 career development award (RR025766). In addition, he also received research grants and/or served as a scientific consultant/advisor for AstraZeneca, Bristol-Myers Squibb, Elan, Forest, Ortho-McNeil Janssen and Pfizer. NR 49 TC 6 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD MAY PY 2013 VL 345 IS 5 BP 343 EP 348 DI 10.1097/MAJ.0b013e31825b8edf PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 130LH UT WOS:000317917800003 PM 22975580 ER PT J AU Kim, J Ebertowski, J Janiga, M Arzola, J Gillespie, G Fountain, M Soderdahl, D Canby-Hagino, E Elsamanoudi, S Gurski, J Davis, JW Parker, PA Boyd, DD AF Kim, Jeri Ebertowski, James Janiga, Matthew Arzola, Jorge Gillespie, Gayle Fountain, Michael Soderdahl, Douglas Canby-Hagino, Edith Elsamanoudi, Sally Gurski, Jennifer Davis, John W. Parker, Patricia A. Boyd, Douglas D. TI Many young men with prostate-specific antigen (PSA) screen-detected prostate cancers may be candidates for active surveillance SO BJU INTERNATIONAL LA English DT Article DE very-low-risk prostatic neoplasms; active surveillance; risk assessment; overtreatment ID RADICAL PROSTATECTOMY; INSIGNIFICANT; SURVIVAL; OUTCOMES; AGE; DIAGNOSIS; DATABASE; TIME AB What's known on the subject? and What does the study add? Little is known as to the potential for over-treatment of young men diagnosed with prostate cancer. We show that for men aged 55 years with PSA screen-detected disease, 45% of the tumours are classified as very low risk and 85% of these have favourable pathology, yet most are actively treated. These findings raise the spectre of over-treatment for a group of men likely to be affected by treatment side-effects. Objective To identify a population of young men (aged <55 years at diagnosis) with very-low-risk prostate cancer (stage cT1c, with prostate-specific antigen [PSA] density of <0.15ng/mL/g, Gleason score 6, and 2 positive biopsy cores with <50% tumour involvement) that may be candidates for active surveillance (AS). Patients and Methods We queried a Department of Defense tumour registry and hard-copy records for servicemen diagnosed with prostate cancer from 1987 to 2010. Statistical analyses were undertaken using Fisher's exact and chi-square testing. Results From 19871991 and 20072010, PSA screen-detected tumours diagnosed in men aged 55 years rose >30-fold. Data for a subset of men (174) with PSA screen-detected cancer were evaluable for disease risk assessment. Of the 174 men with screen-detected disease, 81 (47%) had very-low-risk disease. Of that group, 96% (78/81) selected treatment and, of 57 men undergoing radical prostatectomy (RP), the tumours of 49 (86%) carried favourable pathology (organ confined, <10% gland involvement, Gleason 6). Conclusions Nearly half of young men with PSA screen-detected prostate cancer are AS candidates but the overwhelming majority seek treatment. Considering that many tumours show favourable pathology at RP, there is a possibility that these patients may benefit from AS management. C1 [Kim, Jeri] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA. [Ebertowski, James; Soderdahl, Douglas; Canby-Hagino, Edith] San Antonio Mil Med Ctr, San Antonio, TX USA. [Janiga, Matthew] David Grant USAF Med Ctr, Med Grp 60, Travis Afb, CA USA. [Arzola, Jorge; Gillespie, Gayle] Wright Patterson Med Ctr, Med Grp 88, Dayton, OH USA. [Fountain, Michael] Eglin Reg Hosp, Med Grp 96, Eglin AFB, FL USA. [Elsamanoudi, Sally] Walter Reed Natl Mil Med Ctr, Ctr Prostate Dis Res, Bethesda, MD USA. [Gurski, Jennifer] Womack Army Med Ctr, Ft Bragg, NC USA. [Davis, John W.] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA. [Parker, Patricia A.] Univ Texas MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA. [Boyd, Douglas D.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. RP Boyd, DD (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Unit 173, 1515 Holcombe Blvd, Houston, TX 77030 USA. EM dboyd@mdanderson.org FU National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award [UL1 RR024148]; National Institutes of Health through MD Anderson's Cancer Center Support Grant [5 P30 CA016672] FX None declared. Source of funding: supported in part by a National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award grant UL1 RR024148, awarded to D.D.B., and in part by the National Institutes of Health through MD Anderson's Cancer Center Support Grant, 5 P30 CA016672. NR 31 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-4096 J9 BJU INT JI BJU Int. PD MAY PY 2013 VL 111 IS 6 BP 934 EP 940 DI 10.1111/j.1464-410X.2012.11768.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 134SG UT WOS:000318234100014 PM 23350937 ER PT J AU Jugg, B Fairhall, S Smith, A Rutter, S Mann, T Perrott, R Jenner, J Salguero, J Shute, J Sciuto, AM AF Jugg, B. Fairhall, S. Smith, A. Rutter, S. Mann, T. Perrott, R. Jenner, J. Salguero, J. Shute, J. Sciuto, A. M. TI N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine SO CLINICAL TOXICOLOGY LA English DT Article DE Acute lung injury; Inflammation; Inhalation; Mono-sulfoxide; Porcine physiology; Thiol ID INDUCED LUNG INJURY; MASS-SPECTROMETRY; ANESTHETIZED PIG; EXPOSURE; ACETYLCYSTEINE; URINE; QUANTITATION; INHALATION; IMPROVES; SYSTEM AB Context. Sulfur mustard is a blister agent that can cause death by pulmonary damage. There is currently no effective treatment. N-acetyl-L-cysteine (NAC) has mucolytic and antioxidant actions and is an important pre-cursor of cellular glutathione synthesis. These actions may have potential to reduce mustard-induced lung injury. Objective. Evaluate the effect of nebulised NAC as a post-exposure treatment for inhaled sulfur mustard in a large animal model. Materials and methods. Fourteen anesthetized, surgically prepared pigs were exposed to sulfur mustard vapor (100 mu g.kg(-1), 10 min) and monitored, spontaneously breathing, to 12 h. Control animals had no further intervention (n = 6). Animals in the treatment group were administered multiple inhaled doses of NAC (1 ml of 200 mg.ml(-1) Mucomyst (TM) at + 30 min, 2, 4, 6, 8, and 10 h post-exposure, n = 8). Cardiovascular and respiratory parameters were recorded. Arterial blood was collected for blood gas analysis while blood and bronchoalveolar lavage fluid were collected for hematology and inflammatory cell analysis. Urine was collected to detect a sulfur mustard breakdown product. Lung tissue samples were taken for histopathological and post-experimental analyses. Results. Five of six sulfur mustard-exposed animals survived to 12 h. Arterial blood oxygenation (PaO2) and saturation levels were significantly decreased at 12 h. Arterial blood carbon dioxide (PaCO2) significantly increased, and arterial blood pH and bicarbonate (HCO3-) significantly decreased at 12 h. Shunt fraction was significantly increased at 12 h. In the NAC-treated group all animals survived to 12 h (n = 8). There was significantly improved arterial blood oxygen saturation, HCO3- levels, and shunt fraction compared to those of the sulfur mustard controls. There were significantly fewer neutrophils and lower concentrations of protein in lavage compared to sulfur mustard controls. Discussion. NAC's mucolytic and antioxidant properties may be responsible for the beneficial effects seen, improving clinically relevant physiological indices affected by sulfur mustard exposure. Conclusion. Beneficial effects of nebulized NAC were apparent following inhaled sulfur mustard exposure. Further therapeutic benefit may result from a combination therapy approach. C1 [Jugg, B.; Fairhall, S.; Smith, A.; Rutter, S.; Mann, T.; Perrott, R.; Jenner, J.] DSTL, Salisbury SP4 0JQ, Wilts, England. [Salguero, J.] Anim Hlth & Vet Labs Agcy, Specialist Sci Support, Addlestone, Surrey, England. [Shute, J.] Univ Portsmouth, Portsmouth, Hants, England. [Sciuto, A. M.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Jugg, B (reprint author), DSTL, Room C22,Bldg 04, Salisbury SP4 0JQ, Wilts, England. EM bjjugg@dstl.gov.uk; ajsmith@dstl.gov.uk OI Salguero, Francisco Javier/0000-0002-5315-3882 FU Defense Threat Reduction Agency (US Department of Defense) [HDTRA 1-07-C-0027, W81XWH-09-C-0083]; [RESP.CBM.01.10.RC.009] FX This work was supported by the Defense Threat Reduction Agency (US Department of Defense) under Contracts HDTRA 1-07-C-0027 and W81XWH-09-C-0083 in support of RESP.CBM.01.10.RC.009. NR 35 TC 14 Z9 14 U1 3 U2 20 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD MAY PY 2013 VL 51 IS 4 BP 216 EP 224 DI 10.3109/15563650.2013.780208 PG 9 WC Toxicology SC Toxicology GA 130SD UT WOS:000317938600005 PM 23547745 ER PT J AU Dean, RG Houston, JR AF Dean, R. G. Houston, J. R. TI Recent sea level trends and accelerations: Comparison of tide gauge and satellite results SO COASTAL ENGINEERING LA English DT Article DE Sea level rise; Tide gauge records; Satellite altimetry; Sea level acceleration ID TOPEX/POSEIDON; CALIBRATION; JASON-1; SURFACE AB A comprehensive set of 456 monthly tide gauge records is analyzed for trend and acceleration over the same period that satellite altimetry was analyzed (1993 to 2011). Additionally, a 90 tide gauge record subset is analyzed for which GPS data are available. The selection criterion for the tide gauge data is 85% data completion. All measurements are adjusted for vertical land motion. Results from 456 pairs of tide gauges, adjusted for Global Isostatic Adjustment, and satellite recordings located within 1 root-mean-square latitude and longitude separation differences are compared. The tide gauge trends and accelerations are adjusted for spatial bias using the more globally dense satellite data. The average trends of the 456 and 90 gauge sets (3.26 and 2.68 mm/year, respectively) agree reasonably well with the global trend average of the satellite data (3.09 mm/year). Average trends for the 456 tide gauges are also in good agreement (within 95% confidence limits) with trends based on satellite data within the 10 satellite proximity criterion (326 and 331 mm/year, respectively). The trends for the 90 gauges with GPS nearby and qualifying satellite locations are 2.68 and 2.74 mm/year, respectively. For all datasets analyzed, the accelerations are quite strongly negative but the uncertainty is relatively large. Adjustment of the tide gauge trends for spatial bias modified both trends and accelerations significantly and decreased trend differences between the 456 and 90 gauge datasets. The spatially adjusted tide gauge trends (2.95 and 2.72 mm/year, respectively for the 456 and 90 tide gauges sets) are somewhat less than the 10 spatially adjusted satellite data (3.09 mm/year). Whether the increased sea level trend of approximately 3 mm/year measured by the satellites since the 1990's is a long-term increase from the 20th Century value of approximately 1.7 mm/year or part of a cycle will require longer records; however, the negative accelerations support some cyclic character. (C) 2013 Elsevier B.V. All rights reserved. C1 [Dean, R. G.] Univ Florida, Gainesville, FL 32610 USA. [Houston, J. R.] Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Dean, RG (reprint author), Univ Florida, Gainesville, FL 32610 USA. EM dean@coastal.ufl.edu NR 20 TC 11 Z9 11 U1 1 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD MAY PY 2013 VL 75 BP 4 EP 9 DI 10.1016/j.coastaleng.2013.01.001 PG 6 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 112HL UT WOS:000316583200002 ER PT J AU Nath, AK Roberts, LD Liu, Y Mahon, SB Kim, S Ryu, JH Werdich, A Januzzi, JL Boss, GR Rockwood, GA MacRae, CA Brenner, M Gerszten, RE Peterson, RT AF Nath, Anjali K. Roberts, Lee D. Liu, Yan Mahon, Sari B. Kim, Sonia Ryu, Justine H. Werdich, Andreas Januzzi, James L. Boss, Gerry R. Rockwood, Gary A. MacRae, Calum A. Brenner, Matthew Gerszten, Robert E. Peterson, Randall T. TI Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure SO FASEB JOURNAL LA English DT Article DE mitochondria; inosine; zebrafish; riboflavin ID CYTOCHROME-C-OXIDASE; SODIUM-NITROPRUSSIDE; LIPID-PEROXIDATION; SMALL MOLECULES; DIFFERENT MODES; BILE-ACIDS; INTOXICATION; CELLS; INHIBITION; ZEBRAFISH AB Exposure to cyanide causes a spectrum of cardiac, neurological, and metabolic dysfunctions that can be fatal. Improved cyanide antidotes are needed, but the ideal biological pathways to target are not known. To understand better the metabolic effects of cyanide and to discover novel cyanide antidotes, we developed a zebrafish model of cyanide exposure and scaled it for high-throughput chemical screening. In a screen of 3120 small molecules, we discovered 4 novel antidotes that block cyanide toxicity. The most potent antidote was riboflavin. Metabolomic profiling of cyanide-treated zebrafish revealed changes in bile acid and purine metabolism, most notably by an increase in inosine levels. Riboflavin normalizes many of the cyanide-induced neurological and metabolic perturbations in zebrafish. The metabolic effects of cyanide observed in zebrafish were conserved in a rabbit model of cyanide toxicity. Further, humans treated with nitroprusside, a drug that releases nitric oxide and cyanide ions, display increased circulating bile acids and inosine. In summary, riboflavin may be a novel treatment for cyanide toxicity and prophylactic measure during nitroprusside treatment, inosine may serve as a biomarker of cyanide exposure, and metabolites in the bile acid and purine metabolism pathways may shed light on the pathways critical to reversing cyanide toxicity.-Nath, A. K., Roberts, L. D., Liu, Y., Mahon, S. B., Kim, S., Ryu, J. H., Werdich, A., Januzzi, J. L., Boss, G. R., Rockwood, G. A., MacRae, C. A., Brenner, M., Gerszten, R. E., Peterson, R. T. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 27, 1928-1938 (2013). www.fasebj.org C1 [Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Kim, Sonia; Ryu, Justine H.; Januzzi, James L.; Gerszten, Robert E.; Peterson, Randall T.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA USA. [Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Kim, Sonia; Ryu, Justine H.; Januzzi, James L.; Gerszten, Robert E.; Peterson, Randall T.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Cardiol,Dept Med, Charlestown, MA USA. [Nath, Anjali K.; Roberts, Lee D.; Liu, Yan; Gerszten, Robert E.; Peterson, Randall T.] Broad Inst, Cambridge, MA USA. [Mahon, Sari B.; Brenner, Matthew] Univ Calif Irvine, Irvine Med Ctr, Orange, CA 92668 USA. [Werdich, Andreas; MacRae, Calum A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol,Dept Med, Boston, MA 02115 USA. [Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Rockwood, Gary A.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Nath, AK (reprint author), Cardiovasc Res Ctr, 149 13th St, Charlestown, MA 02129 USA. EM anath@cvrc.mgh.harvard.edu; peterson@cvrc.mgh.harvard.edu OI Roberts, Lee/0000-0002-1455-5248 FU U.S. National Institutes of Health (NIH) grant [T32 HL-007208]; NIH Countermeasures Against Chemical Threats (Counter ACT) [U54NS063718, U54NS079201]; CounterACT Program, NIH Office of the Director; National Institute of Allergy and Infectious Diseases, NIH/U.S. Army Medical Research and Materiel Command [Y1-OD-9611-01/A120-B.P2009-1] FX Funding for this project has been provided by U.S. National Institutes of Health (NIH) grant T32 HL-007208 (A.K.N. and Y.L.) and NIH Countermeasures Against Chemical Threats (Counter ACT) grants U54NS063718 and U54NS079201 (S.B.M. and M.B.) and U54NS079201 (R.T.P). The zebrafish research was supported, in part, by the CounterACT Program, NIH Office of the Director, and the National Institute of Allergy and Infectious Diseases, NIH/U.S. Army Medical Research and Materiel Command interagency agreement no. Y1-OD-9611-01/A120-B.P2009-1 (G.A.R.). NR 54 TC 12 Z9 13 U1 2 U2 28 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD MAY PY 2013 VL 27 IS 5 BP 1928 EP 1938 DI 10.1096/fj.12-225037 PG 11 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 134PU UT WOS:000318226100013 PM 23345455 ER PT J AU Wangchuk, S Thapa, B Zangmo, S Jarman, RG Bhoomiboonchoo, P Gibbons, RV AF Wangchuk, Sonam Thapa, Binay Zangmo, Sangay Jarman, Richard G. Bhoomiboonchoo, Piraya Gibbons, Robert V. TI Influenza surveillance from November 2008 to 2011; including pandemic influenza A(H1N1)pdm09 in Bhutan SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Bhutan; H1N1; influenza; pandemic ID A H1N1 AB Objective Describe the influenza A(H1N1) pandemic in Bhutan. Design Observational study from sentinel surveillance sites. Setting Bhutan remains isolated, with only one to two flights a day at the lone airport, no trains, and only three major roads that enter from India. Main outcome measures PCR positive human respiratory samples Results The first case of A(H1N1)pdm09 infection was detected in Bhutan in July 2009, 3 months after the virus was first reported in Mexico in April 2009. During the official WHO pandemic period (11 June 2009 to 8 August 2010), a total of 2149 samples were collected and tested by RT-PCR of which 22.7% (487) were confirmed A(H1N1)pdm09; H3N2, H1N1, and B were positive in 2.2%, 1.1%, and 7.2%, respectively. The highest rate of A(H1N1)pdm09 cases (57.4%) was detected in the 6-20 year-old age group. Importantly, Bhutan increased from 3 sentinel sites in April 2009 to 11 a year later, and in April 2010 established PCR capability for influenza. Conclusions Despite relative isolation, the A(H1N1)pdm09 reached Bhutan within 3 months of identification in Mexico. The H1N1 pandemic has made Bhutan more prepared for epidemics in the future. C1 [Wangchuk, Sonam; Thapa, Binay; Zangmo, Sangay] Minist Hlth, Publ Hlth Lab, Dept Publ Hlth, Thimphu, Bhutan. [Jarman, Richard G.; Bhoomiboonchoo, Piraya; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Wangchuk, S (reprint author), Minist Hlth, Publ Hlth Lab, Dept Publ Hlth, Thimphu, Bhutan. EM sonamphl@health.gov.bt RI Valle, Ruben/A-7512-2013 NR 17 TC 3 Z9 3 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2013 VL 7 IS 3 BP 426 EP 430 DI 10.1111/j.1750-2659.2012.00409.x PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 131XX UT WOS:000318033100029 PM 22813389 ER PT J AU Abdissa, N Induli, M Akala, HM Heydenreich, M Midiwo, JO Ndakala, A Yenesew, A AF Abdissa, Negera Induli, Martha Akala, Hoseah M. Heydenreich, Matthias Midiwo, Jacob O. Ndakala, Albert Yenesew, Abiy TI Knipholone cyclooxanthrone and an anthraquinone dimer with antiplasmodial activities from the roots of Kniphofia foliosa SO PHYTOCHEMISTRY LETTERS LA English DT Article DE Kniphofia foliosa; Asphodelaceae; Roots; Anthraquinone; Knipholone cyclooxanthrone; 10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol; Dianellin; Malaria ID ANTHRONE; CONSTITUENTS; DERIVATIVES AB A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. C1 [Abdissa, Negera; Induli, Martha; Midiwo, Jacob O.; Ndakala, Albert; Yenesew, Abiy] Univ Nairobi, Dept Chem, Nairobi, Kenya. [Induli, Martha] Makerere Univ, Dept Chem, Kampala, Uganda. [Akala, Hoseah M.] USA, Med Res Unit Kenya, Walter Reed Project, Kisumu, AE 09831 USA. [Heydenreich, Matthias] Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke OI Heydenreich, Matthias/0000-0003-1639-4959 FU German Academic Exchange Service (DAAD) through Natural Product Research Network of Eastern and Central Africa (NAPRECA); International Science Program (ISP, Sweden) [KEN-02] FX Negera Abdissa acknowledges the German Academic Exchange Service (DAAD) for the scholarship through Natural Product Research Network of Eastern and Central Africa (NAPRECA). We thank Prof. Sebsebe Demissew of Botany Department, Addis Ababa University for the identification of plant material. Prof. G. Bringmann of Institute of Organic Chemistry, University of Wurzburg is thanked for useful discussion. We are grateful to International Science Program (ISP, Sweden) for research grant (KEN-02). NR 27 TC 4 Z9 4 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1874-3900 J9 PHYTOCHEM LETT JI Phytochem. Lett. PD MAY PY 2013 VL 6 IS 2 BP 241 EP 245 DI 10.1016/j.phytol.2013.02.005 PG 5 WC Plant Sciences; Chemistry, Medicinal SC Plant Sciences; Pharmacology & Pharmacy GA 135EU UT WOS:000318271400019 ER PT J AU Zinnert, JC Via, SM Young, DR AF Zinnert, Julie C. Via, Stephen M. Young, Donald R. TI Distinguishing natural from anthropogenic stress in plants: physiology, fluorescence and hyperspectral reflectance SO PLANT AND SOIL LA English DT Article DE Drought; Salinity; RDX; TNT; Hyperspectral reflectance; Chlorophyll fluorescence; Photosynthesis ID CHLOROPHYLL FLUORESCENCE; WATER-STRESS; C-3 PLANTS; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; SALINITY; DROUGHT; RESPONSES; TNT; PHOTOSYNTHESIS; VEGETATION AB Explosives released into the environment from munitions production, processing facilities, or buried unexploded ordnances can be absorbed by surrounding roots and induce toxic effects in leaves and stems. Research into the mechanisms with which explosives disrupt physiological processes could provide methods for discrimination of anthropogenic and natural stresses. Our objectives were to experimentally evaluate the effects of natural stress and explosives on plant physiology and to link differences among treatments to changes in hyperspectral reflectance for possible remote detection. Photosynthesis, water relations, chlorophyll fluorescence, and hyperspectral reflectance were measured following four experimental treatments (drought, salinity, trinitrotoluene and hexahydro-1,3,5-trinitro-l,3,5-triazine) on two woody species. Principal Components Analyses of physiological and hyperspectral results were used to evaluate the differences among treatments. Explosives induced different physiological responses compared to natural stress responses. Stomatal regulation over photosynthesis occurred due to natural stress, influencing energy dissipation pathways of excess light. Photosynthetic declines in explosives were likely the result of metabolic dysfunction. Select hyperspectral indices could discriminate natural stressors from explosives using changes in the red and near-infrared spectral region. These results show the possibility of using variations in energy dissipation and hyperspectral reflectance to detect plants exposed to explosives in a laboratory setting and are promising for field application using plants as phytosensors to detect explosives contamination in soil. C1 [Zinnert, Julie C.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Zinnert, Julie C.; Via, Stephen M.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Zinnert, JC (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM jczinner@vcu.edu OI Via, Stephen/0000-0002-4640-1673; Via, Stephen/0000-0002-6756-4156 FU U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC); U.S. Army RDECOM ARL Army Research Office [W911NF-06-1-0074] FX authors thank Jared Austin and Jarrod Edwards for assistance in data collection. This research was supported by internal basic research program funds from the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) and (in part) by the U.S. Army RDECOM ARL Army Research Office under grant W911NF-06-1-0074. NR 43 TC 4 Z9 4 U1 1 U2 54 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0032-079X J9 PLANT SOIL JI Plant Soil PD MAY PY 2013 VL 366 IS 1-2 BP 133 EP 141 DI 10.1007/s11104-012-1414-1 PG 9 WC Agronomy; Plant Sciences; Soil Science SC Agriculture; Plant Sciences GA 131JG UT WOS:000317988600011 ER PT J AU Cohen, SP Bicket, MC Jamison, D Wilkinson, I Rathmell, JP AF Cohen, Steven P. Bicket, Mark C. Jamison, David Wilkinson, Indy Rathmell, James P. TI Epidural Steroids A Comprehensive, Evidence-Based Review SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Review ID LOW-BACK-PAIN; LUMBAR DISC HERNIATION; RANDOMIZED CONTROLLED-TRIAL; 2000-2010 TASK-FORCE; ACTIVE CONTROL TRIAL; CERVICAL TRANSFORAMINAL INJECTION; POSTDURAL PUNCTURE HEADACHE; CENTRAL SPINAL STENOSIS; NERVE ROOT COMPRESSION; CONTRAST FLOW PATTERNS AB Epidural steroid injections (ESIs) are the most widely utilized pain management procedure in the world, their use supported by more than 45 placebo-controlled studies and dozens of systematic reviews. Despite the extensive literature on the subject, there continues to be considerable controversy surrounding their safety and efficacy. The results of clinical trials and review articles are heavily influenced by specialty, with those done by interventional pain physicians more likely to yield positive findings. Overall, more than half of controlled studies have demonstrated positive findings, suggesting a modest effect size lasting less than 3 months in well-selected individuals. Transforaminal injections are more likely to yield positive results than interlaminar or caudal injections, and subgroup analyses indicate a slightly greater likelihood for a positive response for lumbar herniated disk, compared with spinal stenosis or axial spinal pain. Other factors that may increase the likelihood of a positive outcome in clinical trials include the use of a nonepidural (eg, intramuscular) control group, higher volumes in the treatment group, and the use of depo-steroid. Serious complications are rare following ESIs, provided proper precautions are taken. Although there are no clinical trials comparing different numbers of injections, guidelines suggest that the number of injections should be tailored to individual response, rather than a set series. Most subgroup analyses of controlled studies show no difference in surgical rates between ESI and control patients; however, randomized studies conducted by spine surgeons, in surgically amenable patients with standardized operative criteria, indicate that in some patients the strategic use of ESI may prevent surgery. (Reg Anesth Pain Med 2013; 38: 175-200) C1 [Cohen, Steven P.; Bicket, Mark C.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.; Jamison, David] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Pain Management Ctr, Bethesda, MD USA. [Wilkinson, Indy] Womack Army Med Ctr, Dept Anesthesiol, Ft Bragg, NC USA. [Rathmell, James P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, MGH Pain Ctr, Boston, MA USA. RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU Center for Rehabilitation Sciences Research, US Army FX This work was funded in part by the Center for Rehabilitation Sciences Research, US Army (to S.P.C.). NR 316 TC 79 Z9 81 U1 1 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-7339 EI 1532-8651 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD MAY-JUN PY 2013 VL 38 IS 3 BP 175 EP 200 DI 10.1097/AAP.0b013e31828ea086 PG 26 WC Anesthesiology SC Anesthesiology GA 131BQ UT WOS:000317966200003 PM 23598728 ER PT J AU Keefer, ML Taylor, GA Garletts, DF Helms, CK Gauthier, GA Pierce, TM Caudill, CC AF Keefer, M. L. Taylor, G. A. Garletts, D. F. Helms, C. K. Gauthier, G. A. Pierce, T. M. Caudill, C. C. TI HIGH-HEAD DAMS AFFECT DOWNSTREAM FISH PASSAGE TIMING AND SURVIVAL IN THE MIDDLE FORK WILLAMETTE RIVER SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE entrainment; high-head dam; reservoir entrapment; turbine mortality; Willamette River ID SUMMER CHINOOK SALMON; COLUMBIA RIVER; JUVENILE SALMONIDS; SNAKE RIVER; NONNATIVE FISHES; HYDROPOWER DAMS; FLOW; MORTALITY; RESERVOIRS; GROWTH AB Many high-head dams in Oregon's Willamette River basin were constructed without fish passage facilities for downstream migrants. Instead, fish pass dams via hydroelectric turbines, surface spillways or deep-water regulating outlets. The availability of these routes varies seasonally with dam operations and reservoir depth, which can fluctuate by tens of meters. To assess how dam and reservoir operations affect fish movement timing and survival, we used rotary screw traps below three Willamette basin dams and at two riverine sites above reservoirs. Traps were operated 2950days over 8years, and >195000 fish were collected. Samples above reservoirs were primarily native salmonids (Oncorhynchus spp.), daces (Rhinichthys spp.) and sculpins (Cottus spp.), while those below dams were often dominated by non-native Centrarchidae. Capture rates at riverine sites were highest from late winter to early summer, coincident with juvenile Chinook salmon emigration. Conversely, collection below dams was largely restricted to late fall and winter when reservoirs were drawn down to annual lows and discharge was high. We hypothesize that winter operations facilitated fish access to dam turbines and regulating outlets, whereas springsummer operations entrapped fish in reservoirs and restricted volitional downstream passage. Total fish mortality was 2% at riverine sites and was 3669% below dams. Estimates were highest for non-native species and juvenile Chinook salmon. Fatal injuries were consistent with traumas related to pressure, shear and contact and there were size-related and morphology-related risk differences. Mitigation opportunities include fish bypass system development, retrofits for existing routes and seasonally appropriate reservoir draw down to allow fish passage. Copyright (c) 2012 John Wiley & Sons, Ltd. C1 [Keefer, M. L.; Caudill, C. C.] Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. [Taylor, G. A.; Garletts, D. F.; Helms, C. K.; Gauthier, G. A.; Pierce, T. M.] USA, Corps Engineers, Lowell, OR USA. RP Keefer, ML (reprint author), Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. EM mkeefer@uidaho.edu RI Caudill, Christopher/M-7906-2014 FU US Army Corps of Engineers (USACE) FX This work was funded by the US Army Corps of Engineers (USACE). We thank the Willamette Hatchery staff, Oregon Department of Fish and Wildlife (ODFW) biologists, USACE maintenance staff and the inter-agency Fish Passage and Hatchery Management Committee for their assistance and cooperation on this project, especially T. Wright, K. Kenaston, K. Reis and J. Ziller. We also thank C. Lewellen and C. Murphy (USACE), and T. Amandi and C. Banner (ODFW) for field assistance. D. Griffith (USACE) provided project oversight and review. NR 54 TC 5 Z9 6 U1 5 U2 47 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD MAY PY 2013 VL 29 IS 4 BP 483 EP 492 DI 10.1002/rra.1613 PG 10 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 131VT UT WOS:000318026000006 ER PT J AU Neuman, MG McKinney, KK Nanau, RM Kong, V Malkiewicz, I Mazulli, T Moussa, G Cohen, LB AF Neuman, Manuela G. McKinney, Kristi K. Nanau, Radu M. Kong, Vincent Malkiewicz, Izabella Mazulli, Tony Moussa, George Cohen, Lawrence B. TI Drug-induced severe adverse reaction enhanced by human herpes virus-6 reactivation SO TRANSLATIONAL RESEARCH LA English DT Article ID INDUCED HYPERSENSITIVITY SYNDROME; STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; HEPATITIS-C-VIRUS; SOLUBLE FAS LIGAND; INTERFERON-GAMMA RELEASE; HUMAN-HERPESVIRUS-6 REACTIVATION; HUMAN HERPESVIRUS-6; ERYTHEMA MULTIFORME; SYSTEMIC SYMPTOMS AB Reactivation of certain latent viruses has been linked with a more severe course of drug-induced hypersensitivity reaction (HSR). For example, reactivation of human herpes virus (HHV)-6 is associated with severe organ involvement and a prolonged course of disease. The present study discusses an HSR developed in a previously healthy male exposed to ceftriaxone, doxycycline, vancomycin, and trimethoprirn/sulfamethoxazole (co-trimoxazole; TMP/SMX). Initially, the patient presented clinical manifestations of HSR, as well as clinical and laboratory measurements compatible with liver and renal failure. Moreover, the patient presented skin desquamation compatible with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis. During the reaction, it was observed HHV-6 reactivation. The severity of clinical symptoms is correlated with HHV-6 titer, as well as with results of the in vitro lymphocyte toxicity assay (LTA). Serum levels of a large panel of cytokines are compared between the patient, a large population of SJS patients, and a cohort of healthy controls, using data collected by our laboratory over the years. HHV-6 was measured in the cell culture media from lymphocytes incubated with each of the 4 drugs. Moreover, we describe a new assay using cytokines released by patient lymphocytes following in vitro exposure to the incriminated drugs as biomarkers of HSR. Based on LTA results, HHV-6 reactivation and cytokine measurements, we establish that only doxycycline and TMP/SMX were involved in the HSR. As result of this analysis, the patient could continue to use the other 2 antibiotics safely. (Translational Research 2013;161:430-440) C1 In Vitro Drug Safety & Biotechnol, Toronto, ON, Canada. Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON, Canada. Univ Toronto, Fac Med, Inst Drug Res, Toronto, ON, Canada. Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada. Univ Toronto, Dept Lab Med, Toronto, ON, Canada. Sunnybrook Hlth Sci Ctr, Dept Gastroenterol, Toronto, ON M4N 3M5, Canada. Univ Toronto, Dept Med, Toronto, ON, Canada. RP Neuman, MG (reprint author), MaRS Discovery Dist, In Vitro Drug Safety & Biotechnol, 101 Coll St,South Tower,Suite 300,Lab 351, Toronto, ON M5G 1L7, Canada. EM manuela.neuman@utoronto.ca FU In Vitro Drug Safety and Biotechnology; HHV-6 Foundation (Santa Barbara, CA) FX The work was partially supported by a grant from In Vitro Drug Safety and Biotechnology.; The authors thank the HHV-6 Foundation (Santa Barbara, CA http://www.hhv-6foundation.org) for financial support and Altona Diagnostics GmbH (Hamburg, Germany) for providing the kit for HHV-6 genotype and viral load. The authors give special thanks to Kristin Loomis (executive director of HHV-6 Foundation) for editorial advice. NR 117 TC 10 Z9 11 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-5244 J9 TRANSL RES JI Transl. Res. PD MAY PY 2013 VL 161 IS 5 BP 430 EP 440 DI 10.1016/j.trsl.2012.12.012 PG 11 WC Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & Experimental SC Medical Laboratory Technology; General & Internal Medicine; Research & Experimental Medicine GA 133MM UT WOS:000318142500007 PM 23333110 ER PT J AU Mal, S Nori, S Narayan, J Prater, JT Avasthi, DK AF Mal, Siddhartha Nori, Sudhakar Narayan, J. Prater, J. T. Avasthi, D. K. TI Ion-irradiation-induced ferromagnetism in undoped ZnO thin films SO ACTA MATERIALIA LA English DT Article DE Zinc oxide; Thin films; Pulsed laser deposition; Magnetic semiconductors; Raman spectra ID ZINC-OXIDE AB We have introduced defects in ZnO epitaxial thin films by swift heavy Ag-107(9+) ion irradiation and investigated systematically their magnetic, electrical and optical properties. Oxygen annealed ZnO films are epitaxial single crystals that exhibit no long-range magnetic order. However, in this paper it is shown that room-temperature ferromagnetism (RTFM) can be introduced in a controlled manner in these films using ion irradiation and that the magnetization increases with ion dose. This qualitatively agrees with earlier studies which showed that RTFM could be induced in ZnO films through either vacuum thermal annealing or pulsed laser annealing below energy densities that lead to melting. Raman studies of the ion irradiated samples revealed dramatic changes in the vibration modes that correlated with increases in the carrier concentration, indicative of lattice disorder and defect creation. We compare these results with those observed in laser irradiated and vacuum annealed samples, and then discuss these findings in the context of defects and defect complexes created during the high-energy heavy ion irradiation process. We propose a unified mechanism to explain RTFM and n-type conductivity enhancements during irradiation, and laser and vacuum annealing. (c) 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Mal, Siddhartha; Nori, Sudhakar; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Avasthi, D. K.] Inter Univ Accelerator Ctr, Mat Sci Grp, New Delhi 110067, India. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu RI Nori, Sudhakar/E-8111-2010; Avasthi, Devesh /D-4712-2013 NR 21 TC 18 Z9 18 U1 2 U2 43 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD MAY PY 2013 VL 61 IS 8 SI SI BP 2763 EP 2768 DI 10.1016/j.actamat.2012.09.071 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 128VL UT WOS:000317797700005 ER PT J AU Jaqua, NT Cunningham, S Laczek, J AF Jaqua, Nathan T. Cunningham, Scott Laczek, Jeffrey TI An Unusual Cause of Rectal Hemorrhage in a Patient With Well-Controlled Ulcerative Colitis Hemorrhage Related to an Ulcerated Colonic Pseudopolyp SO GASTROENTEROLOGY LA English DT Editorial Material C1 [Jaqua, Nathan T.; Cunningham, Scott] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. [Laczek, Jeffrey] Tripler Army Med Ctr, Dept Gastroenterol, Honolulu, HI 96859 USA. RP Jaqua, NT (reprint author), Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD MAY PY 2013 VL 144 IS 5 BP E5 EP E6 DI 10.1053/j.gastro.2013.01.009 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 129BR UT WOS:000317813900003 PM 23523837 ER PT J AU Lin, YX Wang, D Donetsky, D Shterengas, L Kipshidze, G Belenky, G Svensson, SP Sarney, WL Hier, HS AF Lin, Youxi Wang, Ding Donetsky, Dmitry Shterengas, Leon Kipshidze, Gela Belenky, Gregory Svensson, Stefan P. Sarney, Wendy L. Hier, Harry S. TI Conduction- and Valence-Band Energies in Bulk InAs1-xSbx and Type II InAs1-xSbx/InAs Strained-Layer Superlattices SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE InAsSb; SLS; energy-band offsets; bowing; broadening ID BEAM EPITAXIAL-GROWTH; OPTICAL-PROPERTIES; ALLOYS; SEMICONDUCTORS; INSB; GAP AB The energy gaps were studied in two types of structures: unrelaxed bulk InAs1-x Sb (x) layers with x = 0.2 to 0.46 grown on metamorphic buffers and type II InAs1-x Sb (x) /InAs strained-layer superlattices (SLS) with x = 0.225 to 0.296 in the temperature range from T = 13 K to 300 K. All structures were grown on GaSb substrates. The longest wavelength of photoluminescence (PL) at low temperatures was observed from bulk InAs0.56Sb0.44 with a peak at 10.3 mu m and full-width at half-maximum (FWHM) of 11 meV. The PL data for the bulk InAs1-x Sb (x) materials of various compositions imply an energy gap bowing parameter of 0.87 eV. A low-temperature PL peak at 9.1 mu m with FWHM of 13 meV was observed for InAs0.704Sb0.296/InAs SLS. The PL spectrum of InAs0.775Sb0.225/InAs SLS under pulsed excitation revealed a second peak associated with recombination of electrons in the three-dimensional (3D) continuum with holes in the InAs0.775Sb0.225. This experiment determined the conduction-band offset in the InAs0.775Sb0.225/InAs SLS. The energies of the conduction and valence bands in unstrained InAs1-x Sb (x) and their bowing with respect to the Sb composition are discussed. C1 [Lin, Youxi; Wang, Ding; Donetsky, Dmitry; Shterengas, Leon; Kipshidze, Gela; Belenky, Gregory] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. [Svensson, Stefan P.; Sarney, Wendy L.; Hier, Harry S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Lin, YX (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. EM youxi.lin@stonybrook.edu OI LIN, YOUXI/0000-0002-9092-2302 FU NSF [DMR1160843]; Army Research Office [62447EL] FX The work was supported by NSF Grant DMR1160843 and Army Research Office Contract 62447EL. NR 29 TC 14 Z9 14 U1 7 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD MAY PY 2013 VL 42 IS 5 BP 918 EP 926 DI 10.1007/s11664-013-2528-9 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 131JD UT WOS:000317988300024 ER PT J AU Nayak, SK Singh, AK Belegundu, AD Yen, CF AF Nayak, S. K. Singh, A. K. Belegundu, A. D. Yen, C. F. TI Process for design optimization of honeycomb core sandwich panels for blast load mitigation SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Honeycomb; Homogenization; Blast; Optimization; Sandwich plates; Virtual testing ID NUMERICAL-SIMULATION; SHAPE OPTIMIZATION; AIR BLAST; PLATES; BEHAVIOR AB A general process for optimization of a sandwich panel to minimize the effects of air blast loading is presented here. The panel geometry consists of two metal face plates with a crushable honeycomb or other type of core. Optimization is necessary as there is strong coupling between the several variables and the physics, which makes parametric studies relatively ineffective. Virtual testing is used to develop a homogenized model for the stress-strain curve of the honeycomb core, which can be readily applied to other types of cellular core. The homogenized model has been validated by comparison to existing results as well as to results from detailed finite element (FE) models. A design of experiments (DOE) based response surface optimization method in combination with LS-DYNA is used to minimize dynamic deflection or acceleration of the back face plate. Constraints on total mass and on plastic strain in the face plates are imposed. The mechanism of lowering the backface deflection is by increasing front face plate thickness which effectively distributes the blast load to a larger area of the core and avoids local concave deformation of the front face plate. Further, core depth is increased which increases panel stiffness. For acceleration minimization, results again produce a stiffer front face plate, but accompanied by a sufficiently soft core. The mechanism of lowering the backface acceleration is by absorbing energy with low transmitted stress. A clear cut comparison between monolithic metal plates and sandwich plates, for the same loading and failure criteria, is presented here. C1 [Nayak, S. K.; Singh, A. K.; Belegundu, A. D.] Penn State Univ, University Pk, PA 16802 USA. [Nayak, S. K.] Brookhaven Natl Lab, Upton, NY 11973 USA. [Yen, C. F.] USA, Res Lab, WRMD, Aberdeen Proving Ground, MD USA. RP Belegundu, AD (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM adb3@psu.edu FU Army Research Office [50490-EG]; High Performance Computing Group at Penn State FX This material is based upon work partly supported by the Army Research Office, Proposal Number 50490-EG, monitored by Dr. Bruce LaMattina. Partial financial and computational support from the High Performance Computing Group at Penn State under Mr. Vijay Agarwala is gratefully acknowledged. NR 21 TC 3 Z9 3 U1 4 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD MAY PY 2013 VL 47 IS 5 BP 749 EP 763 DI 10.1007/s00158-012-0845-x PG 15 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA 127FV UT WOS:000317683800009 ER PT J AU Poropatich, R Lai, E McVeigh, F Bashshur, R AF Poropatich, Ronald Lai, Eva McVeigh, Francis Bashshur, Rashid TI The U.S. Army Telemedicine and m-Health Program: Making a Difference at Home and Abroad SO TELEMEDICINE AND E-HEALTH LA English DT Article DE behavioral health; mobile health; cell phone; teleconsultation; synchronous; asynchronous; telemedicine; telehealth; military ID TRAUMATIC BRAIN-INJURY; TELEMENTAL HEALTH; SERVICE DELIVERY; MILITARY; TECHNOLOGY AB This article highlights the deployment of telemedicine by the U.S. Army through the various echelons of care and in overseas locations, including range and scope of health services provided by telemedicine in a challenging environment. This is followed by a discussion of technological developments advances in mobile communications likely to change the practice of telemedicine in the military from limited fixed-point access to a highly mobile individual with handheld communication devices. C1 [Poropatich, Ronald; Lai, Eva; McVeigh, Francis] USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. [Poropatich, Ronald] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA 15219 USA. [Lai, Eva] Johns Hopkins Univ, Baltimore, MD USA. [Bashshur, Rashid] Univ Michigan, Ann Arbor, MI 48109 USA. RP Poropatich, R (reprint author), Univ Pittsburgh, Ctr Mil Med Res Hlth Sci, Bridgeside Point 2,Room 410 450 Technol Dr, Pittsburgh, PA 15219 USA. EM rkp19@pitt.edu NR 23 TC 12 Z9 12 U1 0 U2 11 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD MAY PY 2013 VL 19 IS 5 BP 380 EP 386 DI 10.1089/tmj.2012.0297 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 130FR UT WOS:000317899200013 PM 23537383 ER PT J AU O'Hara, JA McGann, P Snesrud, EC Clifford, RJ Waterman, PE Lesho, EP Doi, Y AF O'Hara, Jessica A. McGann, Patrick Snesrud, Erik C. Clifford, Robert J. Waterman, Paige E. Lesho, Emil P. Doi, Yohei TI Novel 16S rRNA Methyltransferase RmtH Produced by Klebsiella pneumoniae Associated with War-Related Trauma SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID RESISTANCE; SURVEILLANCE AB Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization. C1 [O'Hara, Jessica A.; Doi, Yohei] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA. [McGann, Patrick; Snesrud, Erik C.; Clifford, Robert J.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. RP Doi, Y (reprint author), Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA. EM yod4@pitt.edu FU U.S. Army Medical Command; Defense Medical Research and Development Program; Department of Defense Global Emerging Infections Surveillance and Response System (GEIS); Research Scholar Development Award; National Institute of Allergy and Infectious Diseases [K22AI080584] FX Major funding for the MRSN is provided by the U.S. Army Medical Command, the Defense Medical Research and Development Program, and the Department of Defense Global Emerging Infections Surveillance and Response System (GEIS). Y.D. is supported in part through the Research Scholar Development Award funded by the National Institute of Allergy and Infectious Diseases (K22AI080584). NR 18 TC 25 Z9 28 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 2013 VL 57 IS 5 BP 2413 EP 2416 DI 10.1128/AAC.00266-13 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 124ME UT WOS:000317467600061 PM 23478957 ER PT J AU Zurawski, DV Jacobs, AC Thompson, MG Palys, TJ AF Zurawski, Daniel V. Jacobs, Anna C. Thompson, Mitchell G. Palys, Thomas J. TI Reply to "The Dual Personality of Iron Chelators: Growth Inhibitors or Promoters?" SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter ID BIOFILM; CELLS C1 [Zurawski, Daniel V.; Jacobs, Anna C.; Thompson, Mitchell G.; Palys, Thomas J.] Walter Reed Army Inst Res, Dept Wound Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM daniel.zurawski@amedd.army.mil OI Zurawski, Daniel/0000-0002-7920-5601 NR 10 TC 1 Z9 1 U1 1 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 2013 VL 57 IS 5 BP 2434 EP 2434 DI 10.1128/AAC.00134-13 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 124ME UT WOS:000317467600069 PM 23580580 ER PT J AU Bhattacharjee, AK Pomponio, JW Evans, SA Pervitsky, D Gordon, RK AF Bhattacharjee, Apurba K. Pomponio, James W. Evans, Sarah A. Pervitsky, Dmitry Gordon, Richard K. TI Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE In silico pharmacophore modeling; Virtual screening; Subtype selective; Antimuscarinic agents; Atropine ID ACETYLCHOLINE-RECEPTOR; DRUG DISCOVERY; OPPORTUNITIES; MANAGEMENT; BLADDER; POTENT; MICE AB Muscarinic acetylcholine receptors (mAChRs) have five known subtypes which are widely distributed in both the peripheral and central nervous system for regulation of a variety of cholinergic functions. Atropine is a well known muscarinic subtype non-specific antagonist that competitively inhibits acetylcholine (ACh) at postganglionic muscarinic sites. Atropine is used to treat organophosphate (OP) poisoning and resulting seizures in the warfighter because it competitively inhibits acetylcholine (ACh) at the muscarinic cholinergic receptors. ACh accumulates due to OP inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes ACh. However, atropine produces several unwanted side-effects including dilated pupils, blurred vision, light sensitivity, and dry mouth. To overcome these side-effects, our goal was to find an alternative to atropine that emphasizes M1 (seizure prevention) antagonism but has minimum M2 (cardiac) and M3 (e. g., eye) antagonism so that an effective less toxic medical countermeasure may be developed to protect the warfighter against OP and other chemical warfare agents (CWAs). We adopted an in silico pharmacophore modeling strategy to develop features that are characteristics of known M1 subtype-selective compounds and used the model to identify several antagonists by screening an in-house (WRAIR-CIS) compound database. The generated model for the M1 selectivity was found to contain two hydrogen bond acceptors, one aliphatic hydrophobic, and one ring aromatic feature distributed in a 3D space. From an initial identification of about five hundred compounds, 173 compounds were selected through principal component and cluster analyses and in silico ADME/Toxicity evaluations. Next, these selected compounds were evaluated in a subtype-selective in vitro radioligand binding assay. Twenty eight of the compounds showed antimuscarinic activity. Nine compounds showed specificity for M1 receptors and low specificity for M3 receptors. The pK(i) values of the compounds range from 4.5 to 8.5 nM in comparison to a value of 8.7 nM for atropine. 2-(diethylamino)ethyl 2,2-diphenylpropanoate (ZW62841) was found have the best desired selectivity. None of the newly found compounds were previously reported to exhibit antimuscarinic specificity. Both theoretical and experimental results are presented. Published by Elsevier Ltd. C1 [Bhattacharjee, Apurba K.; Pomponio, James W.; Evans, Sarah A.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Activ, Silver Spring, MD 20910 USA. [Pervitsky, Dmitry] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Gordon, Richard K.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Activ, Silver Spring, MD 20910 USA. EM apurba1995@yahoo.com; Richard.k.gordon@us.army.mil FU DTRA [E0041_09_WR_C] FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or reflecting the views of the Department of the Army or the Department of Defense. This work was supported by the DTRA project No. E0041_09_WR_C. NR 42 TC 6 Z9 6 U1 1 U2 45 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD MAY 1 PY 2013 VL 21 IS 9 BP 2651 EP 2662 DI 10.1016/j.bmc.2013.01.072 PG 12 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 123PS UT WOS:000317403200023 PM 23523385 ER PT J AU Cohen, SP Strassels, SA Kurihara, C Griffith, SR Goff, B Guthmiller, K Hoang, HT Morlando, B Nguyen, C AF Cohen, Steven Paul Strassels, Scott A. Kurihara, Connie Griffith, Scott R. Goff, Brandon Guthmiller, Kevin Hoang, Hieu T. Morlando, Benny Nguyen, Conner TI Establishing an Optimal "Cutoff" Threshold for Diagnostic Lumbar Facet Blocks A Prospective Correlational Study SO CLINICAL JOURNAL OF PAIN LA English DT Article DE facet joint; low back pain; predictive value; radiofrequency; specificity; zygapophysial ID LOW-BACK-PAIN; MEDIAL BRANCH BLOCKS; ZYGAPOPHYSIAL JOINT BLOCKS; RADIOFREQUENCY DENERVATION; DOUBLE-BLIND; COST-EFFECTIVENESS; RANDOMIZED-TRIAL; IMMPACT RECOMMENDATIONS; MULTICENTER ANALYSIS; CLINICAL IMPORTANCE AB Objectives: Diagnostic medial branch blocks (MBB) are considered the reference standard for diagnosing facetogenic pain and selecting patients for radiofrequency (RF) denervation. Great controversy exists regarding the ideal cutoff for designating a block as positive. The purpose of this study is to determine the optimal pain relief threshold for selecting patients for RF denervation after diagnostic MBB. Methods: In this multicenter, prospective correlational study, 61 consecutive patients undergoing lumbar facet RF denervation after experiencing significant pain relief after MBB were enrolled. A positive outcome was defined as a >= 50% reduction in back pain at rest or with activity coupled with a positive satisfaction score lasting longer than 3 months. The relationship between pain relief after the blocks and denervation outcomes was evaluated by pairwise correlation matrix, receiver's operating characteristic curve, and stratifying outcomes based on 10- and 17-percentage point intervals for MBB. Results: There were no significant differences in RF outcomes based on any MBB pain relief cutoff over 50%. A trend was noted whereby those patients who obtained <50% pain relief reported poorer outcomes. No optimal threshold for designating a diagnostic block as positive, above 50% pain relief, could be calculated. Conclusion: Employing more stringent selection criteria for lumbar facet RF is likely to result in withholding a beneficial procedure from a substantial number of patients, without improving success rates. C1 [Cohen, Steven Paul] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven Paul] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Kurihara, Connie; Morlando, Benny] Walter Reed Army Med Ctr, Dept Surg, Pain Management Div, Anesthesia Serv, Washington, DC USA. [Griffith, Scott R.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Dept Anesthesiol, Bethesda, MD 20814 USA. [Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA. [Goff, Brandon] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, Dept Phys Med & Rehabil, San Antonio, TX USA. [Guthmiller, Kevin; Hoang, Hieu T.] Brooke Army Med Ctr, Dept Anesthesiol, Ft Sam Houston, TX 78234 USA. [Nguyen, Conner] Landstuhl Reg Med Ctr, Dept Surg, Phys Med & Rehabil Serv, Landstuhl, Germany. RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu OI Goff, Brandon/0000-0002-5665-9395 FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; US Army; Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC FX Supported in part by a Congressional Grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; and the US Army; and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC. The authors declare no conflicts of interest. NR 59 TC 8 Z9 8 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-8047 J9 CLIN J PAIN JI Clin. J. Pain PD MAY PY 2013 VL 29 IS 5 BP 382 EP 391 DI 10.1097/AJP.0b013e31825f53bf PG 10 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 124QT UT WOS:000317481300002 PM 23023310 ER PT J AU Dickinson, DP Coleman, BG Batrice, N Lee, J Koli, K Pennington, C Susin, C Wikesjo, UME AF Dickinson, Douglas P. Coleman, Brandon G. Batrice, Nathan Lee, Jaebum Koli, Komal Pennington, Cathy Susin, Cristiano Wikesjoe, Ulf M. E. TI Events of wound healing/regeneration in the canine supraalveolar periodontal defect model SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE cementum; critical-size defect; osteoid; periodontal ligament; periodontal regeneration; reparative tissue; wound healing ID MESENCHYMAL STEM-CELLS; GUIDED TISSUE REGENERATION; BARRIER MEMBRANES; INTRABONY DEFECTS; REPAIR; DOGS; LIGAMENT; CEMENTOGENESIS; INDUCTION; RATS AB Aim The objective of this research was to elucidate early events in periodontal wound healing/regeneration using histological and immunohistochemical techniques. Methods Routine critical-size, supraalveolar, periodontal defects including a space-providing titanium mesh device were created in 12 dogs. Six animals received additional autologous blood into the defect prior to wound closure. One animal from each group was killed for analysis at 2, 5, 9, 14days, and at 4 and 8weeks. Results Both groups behaved similarly. Periodontal wound healing/regeneration progressed through three temporal phases. Early phase (25days): heterogeneous clot consolidation and cell activation in the periodontal ligament (PDL) and trabecular bone was associated with PDL regeneration and formation of a pre-osteoblast population. Intermediate phase (914days): cell proliferation (shown by PCNA immunostaining)/migration led to osteoid/bone, PDL and cementum formation. Late phase (48weeks): primarily characterized by tissue remodelling/maturation. Fibrous connective tissue from the gingival mucosa entered the wound early, competing with regeneration. By day 14, the wound space was largely filled with regenerative and reparative tissues. Conclusion Activation of cellular regenerative events in periodontal wound healing/regeneration is rapid; the general framework for tissue formation is broadly outlined within 14days. Most bone formation apparently originates from endosteally derived pre-osteoblasts; the PDL possibly acting as a supplementary source, with a primary function likely being regulatory/homeostatic. Blood accumulation at the surgical site warrants exploration; supplementation may be beneficial. C1 [Dickinson, Douglas P.; Coleman, Brandon G.; Batrice, Nathan; Lee, Jaebum; Koli, Komal; Pennington, Cathy; Susin, Cristiano; Wikesjoe, Ulf M. E.] Georgia Regents Univ, Coll Dent Med, Lab Appl Periodontal & Craniofacial Regenerat, Augusta, GA USA. [Dickinson, Douglas P.] Camellix LLC, Augusta, GA 30912 USA. [Coleman, Brandon G.; Batrice, Nathan] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. RP Dickinson, DP (reprint author), Camellix LLC, 1120 15th St CA2149, Augusta, GA 30912 USA. EM dougdickinson4357@gmail.com RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009; OI Wikesjo, Ulf/0000-0003-1607-0583; Coleman, Brandon/0000-0001-5799-303X FU Georgia Regents University College of Dental Medicine Nobel Biocare Center for Excellence [2008-764]; US Army Advanced Education Program in Periodontics, Fort Gordon; Georgia Regents University College of Dental Medicine; Nobel Biocare FX This study was supported by an award (2008-764) to Dr. Douglas P Dickinson from the Georgia Regents University College of Dental Medicine Nobel Biocare Center for Excellence, periodontics residency training grant awards to Drs. Brandon G Coleman and Nathan Batrice from the US Army Advanced Education Program in Periodontics, Fort Gordon, and by the Georgia Regents University College of Dental Medicine. Drs. Ulf ME Wikesjo, Cristiano Susin, and Jaebum Lee are supported by grants to the Laboratory for Applied Periodontal & Craniofacial Regeneration from Nobel Biocare. NR 32 TC 10 Z9 10 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD MAY PY 2013 VL 40 IS 5 BP 527 EP 541 DI 10.1111/jcpe.12055 PG 15 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 122BN UT WOS:000317290100010 PM 23461721 ER PT J AU Herbert, AS Kuehne, AI Barth, JF Ortiz, RA Nichols, DK Zak, SE Stonier, SW Muhammad, MA Bakken, RR Prugar, LI Olinger, GG Groebner, JL Lee, JS Pratt, WD Custer, M Kamrud, KI Smith, JF Hart, MK Dye, JM AF Herbert, Andrew S. Kuehne, Ana I. Barth, James F. Ortiz, Ramon A. Nichols, Donald K. Zak, Samantha E. Stonier, Spencer W. Muhammad, Majidat A. Bakken, Russell R. Prugar, Laura I. Olinger, Gene G. Groebner, Jennifer L. Lee, John S. Pratt, William D. Custer, Max Kamrud, Kurt I. Smith, Jonathan F. Hart, Mary Kate Dye, John M. TI Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus SO JOURNAL OF VIROLOGY LA English DT Article ID HEMORRHAGIC-FEVER; MARBURG VIRUS; ALPHAVIRUS VECTORS; GUINEA-PIGS; INFECTION; DISEASE; RNA; IMMUNIZATION; EXPRESSION; FAMILY AB There are no vaccines or therapeutics currently approved for the prevention or treatment of ebolavirus infection. Previously, a replicon vaccine based on Venezuelan equine encephalitis virus (VEEV) demonstrated protective efficacy against Marburg virus in nonhuman primates. Here, we report the protective efficacy of Sudan virus (SUDV)- and Ebola virus (EBOV)-specific VEEV replicon particle (VRP) vaccines in nonhuman primates. VRP vaccines were developed to express the glycoprotein (GP) of either SUDV or EBOV. A single intramuscular vaccination of cynomolgus macaques with VRP expressing SUDV GP provided complete protection against intramuscular challenge with SUDV. Vaccination against SUDV and subsequent survival of SUDV challenge did not fully protect cynomolgus macaques against intramuscular EBOV back-challenge. However, a single simultaneous intramuscular vaccination with VRP expressing SUDV GP combined with VRP expressing EBOV GP did provide complete protection against intramuscular challenge with either SUDV or EBOV in cynomolgus macaques. Finally, intramuscular vaccination with VRP expressing SUDV GP completely protected cynomolgus macaques when challenged with aerosolized SUDV, although complete protection against aerosol challenge required two vaccinations with this vaccine. C1 [Herbert, Andrew S.; Kuehne, Ana I.; Barth, James F.; Ortiz, Ramon A.; Nichols, Donald K.; Zak, Samantha E.; Stonier, Spencer W.; Muhammad, Majidat A.; Bakken, Russell R.; Prugar, Laura I.; Olinger, Gene G.; Groebner, Jennifer L.; Lee, John S.; Pratt, William D.; Hart, Mary Kate; Dye, John M.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Custer, Max; Kamrud, Kurt I.; Smith, Jonathan F.] AlphaVax Inc, Res Triangle Pk, NC USA. RP Dye, JM (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA. EM john.m.dye1@us.army.mil RI sebastianovitsch, stepan/G-8507-2013; OI Groebner, Jennifer/0000-0003-1503-5030; Olinger, Gene/0000-0001-7338-0292; Lee, John/0000-0001-7605-1814 FU Defense Threat Reduction Agency [CBM.VAXPLAT.05.10.RD.005] FX This study was kindly supported by the Defense Threat Reduction Agency (project CBM.VAXPLAT.05.10.RD.005). NR 48 TC 33 Z9 36 U1 1 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2013 VL 87 IS 9 BP 4952 EP 4964 DI 10.1128/JVI.03361-12 PG 13 WC Virology SC Virology GA 123UK UT WOS:000317416400016 PM 23408633 ER PT J AU McAlpin, TO Savant, G Brown, GL Smith, SJ Chapman, RS AF McAlpin, Tate O. Savant, Gaurav Brown, Gary L. Smith, S. Jarrell Chapman, Raymond S. TI Hydrodynamics of Knik Arm: Modeling Study SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Adaptive hydraulics; AdH; Anchorage; Numerical modeling of eddies; Knik Arm; Cook Inlet; Cairn Point ID COOK-INLET; COASTAL HEADLAND; EDDY FORMATION; ALASKA; MOVEMENT; WATER AB An adaptive hydraulics (AdH) model was applied to lower Knik Arm near the Port of Anchorage, Alaska, to assess its ability to model a macrotidal system with complex hydrodynamics, including the formation and evolution of numerous gyres that are prominent at this site. Lower Knik Arm is an ideal system for this model evaluation because of the large tide range (approximately 10m at Anchorage) and complex geometry of the system, which results in high velocities and the formation of numerous eddies throughout the study area. One eddy of primary importance is the one generated by Cairn Point, which occurs near the Port of Anchorage. Limitations of previous modeling studies and the availability of recent field data enabled this evaluation. The AdH results were compared with field data (water surface elevations, fluxes, and velocities) collected in August of 2002 and 2006, and favorable comparisons obtained for tidal amplification and eddy generation indicate that AdH reasonably reproduces the complex hydrodynamic conditions in lower Knik Arm. Simulations were also performed to investigate the importance of eddy viscosity specification, frictional specification, and bathymetry on the generation/evolution of eddies present in the system. Upon completion of the model validation, simulations were performed with modified Cairn Point configurations to investigate the impact to the eddy generated at the port. These results illustrate the variation in eddy generation through lengthening, lowering/reducing, or raising Cairn Point. DOI: 10.1061/(ASCE)WW.1943-5460.0000171. (C) 2013 American Society of Civil Engineers. C1 [McAlpin, Tate O.; Savant, Gaurav; Brown, Gary L.; Smith, S. Jarrell; Chapman, Raymond S.] USA, Coastal & Hydraul Lab, Corps Engineers, Vicksburg, MS 39180 USA. [Savant, Gaurav] Dynam Solut LLC, Water Resources, Knoxville, TN 37919 USA. RP McAlpin, TO (reprint author), USA, Coastal & Hydraul Lab, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM tate.o.mcalpin@usace.army.mil FU U.S. Army Corp of Engineers Alaska District; U.S. Army Corp of Engineers System Wide Water Resources Program (SWWRP) FX The work described and results presented in this paper were obtained through research sponsored by the U.S. Army Corp of Engineers Alaska District and the U.S. Army Corp of Engineers System Wide Water Resources Program (SWWRP). Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corp of Engineers. NR 47 TC 1 Z9 1 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD MAY PY 2013 VL 139 IS 3 BP 232 EP 246 DI 10.1061/(ASCE)WW.1943-5460.0000171 PG 15 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 123WW UT WOS:000317423400008 ER PT J AU Taflanidis, AA Kennedy, AB Westerink, JJ Smith, J Cheung, KF Hope, M Tanaka, S AF Taflanidis, Alexandros A. Kennedy, Andrew B. Westerink, Joannes J. Smith, Jane Cheung, Kwok Fai Hope, Mark Tanaka, Seizo TI Rapid Assessment of Wave and Surge Risk during Landfalling Hurricanes: Probabilistic Approach SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Hurricane risk; Surge; Waves; Response surface surrogate modeling; Joint probability method ID RESPONSE FUNCTION-APPROACH; EMERGENCY MANAGEMENT; RUNUP; TRANSFORMATION; OPTIMIZATION; BREAKING AB A probabilistic framework is presented for evaluation of hurricane wave and surge risk with particular emphasis on real-time automated estimation for hurricanes approaching landfall. This framework has two fundamental components. The first is the development of a surrogate model for the rapid evaluation of hurricane waves, water levels, and run-up based on a small number of parameters describing each hurricane: hurricane landfall location and heading, central pressure, forward speed, and radius of maximum winds. This surrogate model is developed using a response surface methodology fed by information from hundreds of precomputed, high-resolution Simulating Waves Nearshore (SWAN) 1 Advanced Circulation Model for Oceanic, Coastal and Estuarine Waters (ADCIRC) and One-Dimensional Boussinesq Model (BOUSS-1D) runs. Fora specific set of hurricane parameters (i.e., a specific landfalling hurricane), the surrogate model is able to evaluate the maximum wave height, water level, and run-up during the storm at a cost that is more than seven orders of magnitude less than the high-fidelity models and thus meets time constraints imposed by emergency managers and decision makers. The second component of this framework is a description of the uncertainty in the parameters used to characterize the hurricane through appropriate probability models, which then leads to quantification of hurricane risk in terms of a probabilistic integral. This integral is then efficiently computed using the already established surrogate model by analyzing thousands of different scenarios (based on the aforementioned probabilistic description). This allows the rapid computation of, for example, the storm surge that might be exceeded 10% of the time based on hurricane parameters at 48 h from landfall. Finally, by leveraging the computational simplicity and efficiency of the surrogate model, a simple stand-alone PC-based risk-assessment tool is developed that allows nonexpert end users to take advantage of the full potential of the framework. The proposed framework ultimately facilitates the development of a rapid assessment tool for real-time implementation but requires a considerable upfront computational cost to produce high-fidelity model results. As an illustrative example, implementation of hurricane risk estimation for the Island of Oahu in Hawaii is presented; results demonstrate the versatility of the proposed approach for delivering accurate tools for real-time hurricane risk estimation that have the ability to cross over technology adoption barriers. DOI: 10.1061/(ASCE)WW.1943-5460.0000178. (C) 2013 American Society of Civil Engineers. C1 [Taflanidis, Alexandros A.; Kennedy, Andrew B.; Westerink, Joannes J.; Hope, Mark] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Smith, Jane] USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. [Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. [Tanaka, Seizo] Univ Tokyo, Div Disaster Mitigat Sci, Bunkyo Ku, Tokyo 1130032, Japan. RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. EM a.taflanidis@nd.edu RI Kennedy, Andrew/E-4746-2011; OI Kennedy, Andrew/0000-0002-7254-1346; Taflanidis, Alexandros/0000-0002-9784-7480 FU U.S. Army Corps of Engineering [W912HZ-09-C-0086] FX This research effort was supported by U.S. Army Corps of Engineering Grant No. W912HZ-09-C-0086 under the Surge and Wave Island Modeling Studies, Coastal Field Data Collection Program. This support is greatly appreciated. Permission to publish this work was granted by the Chief of Engineers, U. S. Army Corps of Engineers. The authors also thank Dr. Rick Knabb, formerly of the Central Pacific Hurricane Center, for his contribution in selecting the suite of hurricane scenarios used in this study. NR 44 TC 7 Z9 7 U1 2 U2 20 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY PY 2013 VL 139 IS 3 BP 171 EP 182 DI 10.1061/(ASCE)WW.1943-5460.0000178 PG 12 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 123WW UT WOS:000317423400003 ER PT J AU Darlington, DN Craig, T Gonzales, MD Schwacha, MG Cap, AP Dubick, MA AF Darlington, Daniel N. Craig, Teresa Gonzales, Mary D. Schwacha, Martin G. Cap, Andrew P. Dubick, Michael A. TI ACUTE COAGULOPATHY OF TRAUMA IN THE RAT SO SHOCK LA English DT Article DE Coagulation; polytrauma; hemorrhage; clotting firmness; platelets; fibrinogen; PT; aPTT ID ACTIVATED PROTEIN-C; PLATELET DYSFUNCTION; VASCULAR-RESISTANCE; COMBAT CASUALTIES; BLOOD-VOLUME; HEMORRHAGE; RESUSCITATION; COAGULATION; MORTALITY; INJURY AB Introduction: Acute coagulopathy of trauma (aCOT) is a state of disordered coagulation developing soon after severe injury and blood loss and has been defined in the clinical literature as an elevation in prothrombin time (PT) and activated partial thromboplastin time (aPTT). Objective: The purpose of this study was to develop a rat model of aCOT resulting from polytrauma and hemorrhage and showing an elevation in PT and aPTT. Methods: Sprague-Dawley rats (300-400 g) were anesthetized with isoflurane. Polytrauma was induced by damaging 10 cm of small intestines, the right and medial liver lobes, the right leg skeletal muscle, and fracture of the right femur. Rats were hemorrhaged 40% of their estimated blood volume. No resuscitation was given. Venous and arterial blood samples were taken at times up to 4 h. Results: Polytrauma and hemorrhage resulted in a significant rise in PT, aPTT, potassium, lactate, and glucose. There was a significant decrease in plasma bicarbonate, base excess, and sodium. Blood urea nitrogen and creatinine rose steadily throughout the 4 h indicative of progressive renal failure. Hematocrit decreased significantly immediately after hemorrhage and trauma indicating a movement of fluid into the vascular space from extravascular sources, which was mirrored by a decrease in plasma fibrinogen concentration. In contrast, platelet count initially decreased, rose at 2 h, and decreased again at 3 to 4 h, indicating that platelets were released into the vascular space. The change in platelet count was mirrored by the changes in thrombin-antithrombin and plasmin-antiplasmin complexes. Rotational thromboelastometry showed complex changes. Clotting firmness fell initially, rose at 2 h, and fell again at 3 to 4 h similar to the changes in platelet count. alpha Angle was elevated, and clotting time was shortened over the 4 h. Treatment with cytochalasin D (platelet function inhibitor) eliminated the increases in clotting firmness and thrombin generation seen at 2 h with rising platelet count. Conclusions: This model of aCOT in rats showed complex changes in clotting parameters over 4 h that included a rise in PT and aPTT. At 4 h, there was a decrease in clotting firmness, even though the clot formation was faster (elevated ! angle and decrease in clotting time). The decrease in clotting firmness correlated with falling fibrinogen and platelet count. This model affords an opportunity to evaluate interventions in the treatment of aCOT. C1 [Darlington, Daniel N.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Darlington, DN (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM daniel.darlington@amedd.army.mil FU US Army Medical Research Materiel Command FX Support for this study was received from the US Army Medical Research Materiel Command. NR 40 TC 24 Z9 24 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD MAY PY 2013 VL 39 IS 5 BP 440 EP 446 DI 10.1097/SHK.0b013e31829040e3 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 127XE UT WOS:000317731400007 PM 23481505 ER PT J AU Lin, LJ Grimme, JM Sun, J Lu, SY Gai, LS Cropek, DM Wang, YX AF Lin, Li-Jung Grimme, Jill M. Sun, Jie Lu, Shaoying Gai, Lisa Cropek, Donald M. Wang, Yingxiao TI The antagonistic roles of PDGF and integrin alpha v beta 3 in regulating ROS production at focal adhesions SO BIOMATERIALS LA English DT Article DE Fluorescence resonance energy transfer (FRET); Focal adhesion (FA); Integrin; Platelet derived growth factor (PDGF); Reactive oxygen species (ROS) ID ACTIN STRESS FIBERS; STEM-CELL FATE; ALPHA(V)BETA(3) INTEGRIN; MEMBRANE PROTRUSION; SIGNAL-TRANSDUCTION; GROWTH-FACTORS; RAC; RHO; GTPASES; ACTIVATION AB Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosensor capable of monitoring ROS production at FA sites in live cells with high sensitivity and specificity, utilizing fluorescence resonance energy transfer (FRET). The results revealed that platelet derived growth factor (PDGF) can induce ROS production at FA sites, which is mediated by Rac1 activation. In contrast, integrins, specifically integrin alpha v beta 3, inhibits this local ROS production. The RhoA activity can mediate this inhibitory role of integrins in regulating ROS production. Therefore, PDGF and integrin alpha v beta 3 coordinate to have an antagonistic effect in the ROS production at FA sites to regulate cell adhesion and migration. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Lin, Li-Jung; Sun, Jie; Lu, Shaoying; Wang, Yingxiao] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA. [Grimme, Jill M.; Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Gai, Lisa] Harvey Mudd Coll, Dept Engn, Claremont, CA 91711 USA. [Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA. [Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Neurosci Program, Urbana, IL 61801 USA. [Wang, Yingxiao] Univ Illinois, Inst Genom Biol, Beckman Inst Adv Sci & Technol, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA. RP Wang, YX (reprint author), Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA. EM Donald.M.Cropek@usace.army.mil; yingxiao@illinois.edu FU US Army Engineer Research and Development Center (ERDC) Broad Agency Announcement (BAA); NIH [HL098472]; NSF [CBET0846429]; Beckman Laser Institute, Inc. FX We thank Steve Guo and Yue Zhuo for data analysis. This work is supported in part by grants from the US Army Engineer Research and Development Center (ERDC) Broad Agency Announcement (BAA) (Y.W. and D.M.C.), NIH HL098472, NSF CBET0846429, and Beckman Laser Institute, Inc. (Y.W.). NR 48 TC 7 Z9 7 U1 0 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD MAY PY 2013 VL 34 IS 15 BP 3807 EP 3815 DI 10.1016/j.biomaterials.2013.01.092 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 120KH UT WOS:000317168700008 PM 23465490 ER PT J AU Serge, SR Priest, HA Durlach, PJ Johnson, CI AF Serge, Stephen R. Priest, Heather A. Durlach, Paula J. Johnson, Cheryl I. TI The effects of static and adaptive performance feedback in game-based training SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Adaptive feedback; Game-based training; Instruction; Virtual environments ID COGNITIVE-LOAD; DISCOVERY; SPECIFICITY; ENVIRONMENT; KNOWLEDGE AB Training in virtual environments (VEs) has the potential to establish mental models and task mastery while providing a safe environment in which to practice. Performance feedback is known to contribute to this learning; however, the most effective ways to provide feedback in VEs have not been established. The present study examined the effects of differing feedback content, focusing on adaptive feedback. Participants learned search procedures during multiple missions in a VE. A control group received only a performance score after each mission. Two groups additionally received either detailed or general feedback after each mission, while two other groups received feedback that adapted based on their performance (either detailed-to-general, or general-to-detailed). Groups that received detailed feedback from the start of training had faster performance improvement than all other groups; however, all feedback groups showed improved performance and by the fourth mission performed at levels above the control group. Results suggest that detailed feedback early in the training cycle is the most beneficial for the fastest learning of new task skills in VEs. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Serge, Stephen R.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. [Serge, Stephen R.] USA, Res Inst, Consortium Res Fellows Program, Orlando, FL 32826 USA. [Priest, Heather A.; Durlach, Paula J.; Johnson, Cheryl I.] USA, Res Inst Behav & Social Sci, Orlando, FL 32826 USA. RP Serge, SR (reprint author), Univ Cent Florida, Dept Psychol, POB 161390, Orlando, FL 32816 USA. EM stephen-serge@us.army.mil; heather.priest@us.army.mil; paula.durlach@us.army.mil; cheryl.i.johnson@us.army.mil NR 35 TC 10 Z9 10 U1 7 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD MAY PY 2013 VL 29 IS 3 BP 1150 EP 1158 DI 10.1016/j.chb.2012.10.007 PG 9 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 114UX UT WOS:000316769300071 ER PT J AU Damarla, T Bradley, M Mehmood, A Sabatier, JM AF Damarla, Thyagaraju Bradley, Marshall Mehmood, Asif Sabatier, James M. TI Classification of Animals and People Ultrasonic Signatures SO IEEE SENSORS JOURNAL LA English DT Article DE Classification; micro-Doppler; support vector machine; ultrasonic sensor AB Personnel detection using inexpensive nonimaging sensors is becoming increasingly important for several applications, namely, border surveillance, perimeter protection, and urban operations. In this paper, we explore the utility of ultrasonic sensors to distinguish between people and animals walking. We explore the phenomenology associated with human and animal walking and identify model-based features in the spectrogram. In particular, we study the properties of micro-Doppler returns from various body parts (limbs) of the people and animals to identify the features. Finally, we develop two algorithms for classifying people and animals using the micro-Doppler signatures: one algorithm for the case when the signal-to-noise ratio (SNR) is high and another for low SNR. A support vector machine and a Bayesian classifier were used to classify the targets when the SNR is low. We present the results of the algorithms applied to actual data collected at a horse farm. C1 [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. [Bradley, Marshall] LogLinear Grp, Waveland, MS 39576 USA. [Mehmood, Asif] USAF, Inst Technol, Wright Patterson AFB, OH 45433 USA. [Sabatier, James M.] Univ Mississippi, Natl Ctr Phys Acoust, Oxford, MS 38655 USA. RP Damarla, T (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM thyagaraju.damarla.civ@mail.mil; marshall.bradley@loglineargroup.com; asif.mehmood.ctr@afit.edu; sabatier@oldmiss.edu NR 23 TC 4 Z9 4 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY PY 2013 VL 13 IS 5 BP 1464 EP 1472 DI 10.1109/JSEN.2012.2236550 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 118DV UT WOS:000317003900013 ER PT J AU Martyr, RC Dietrich, JC Westerink, JJ Kerr, PC Dawson, C Smith, JM Pourtaheri, H Powell, N Van Ledden, M Tanaka, S Roberts, HJ Westerink, HJ Westerink, LG AF Martyr, R. C. Dietrich, J. C. Westerink, J. J. Kerr, P. C. Dawson, C. Smith, J. M. Pourtaheri, H. Powell, N. Van Ledden, M. Tanaka, S. Roberts, H. J. Westerink, H. J. Westerink, L. G. TI Simulating Hurricane Storm Surge in the Lower Mississippi River under Varying Flow Conditions SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article DE Storm surge; Mississippi River; Hurricanes; Rivers; Hydrodynamics; Numerical models; Storm surge generation; Propagation and attenuation ID SHALLOW-WATER EQUATIONS; SEDIMENT-TRANSPORT; SOUTHERN LOUISIANA; MODEL; WAVE; PERFORMANCE; DISCHARGE; HINDCAST; STAGE; VALIDATION AB Hurricanes in southeastern Louisiana develop significant surges within the lower Mississippi River. Storms with strong sustained easterly winds push water into shallow Breton Sound, overtop the river's east bank south of Pointe a la Hache, Louisiana, penetrate into the river, and are confined by levees on the west bank. The main channel's width and depth allow surge to propagate rapidly and efficiently up river. This work refines the high-resolution, unstructured mesh, wave current Simulating Waves Nearshore + Advanced Circulation (SWAN + ADCIRC) SL16 model to simulate river flow and hurricane-driven surge within the Mississippi River. A river velocity regime-based variation in bottom friction and a temporally variable riverine flow-driven radiation boundary condition are essential to accurately model these processes for high and/or time-varying flows. The coupled modeling system is validated for riverine flow stage relationships, flow distributions within the distributary systems, tides, and Hurricane Gustav (2008) riverine surges. DOI: 10.1061/(ASCE)HY.1943-7900.0000699. (C) 2013 American Society of Civil Engineers. C1 [Martyr, R. C.; Westerink, J. J.; Kerr, P. C.; Westerink, H. J.; Westerink, L. G.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Dietrich, J. C.; Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Smith, J. M.] USA, Coastal Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Pourtaheri, H.; Powell, N.] USA, Corps Engineers, New Orleans, LA 70118 USA. [Van Ledden, M.] Haskoning Nederland BV, Rotterdam, Netherlands. [Tanaka, S.] Univ Tokyo, Earthquake Res Inst, Tokyo 1130032, Japan. [Roberts, H. J.] ARCADIS INC, Boulder, CO 80301 USA. RP Martyr, RC (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. EM rmartyr@nd.edu RI Dietrich, Joel/E-5161-2011 OI Dietrich, Joel/0000-0001-5294-2874 FU United States Army Corps of Engineers (USACE) New Orleans District (MVN); USACE System-Wide Water Resources and Morphos Programs FX This work was supported by the United States Army Corps of Engineers (USACE) New Orleans District (MVN) and the USACE System-Wide Water Resources and Morphos Programs. Computational resources and support were provided by the University of Texas at Austin Texas Advanced Computing Center (TACC). Permission to publish this paper was granted by the Chief of Engineers, USACE. NR 38 TC 8 Z9 10 U1 2 U2 31 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAY PY 2013 VL 139 IS 5 BP 492 EP 501 DI 10.1061/(ASCE)HY.1943-7900.0000699 PG 10 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 123XH UT WOS:000317424700004 ER PT J AU Blyth, DM Chung, KK Cancio, LC King, BT Murray, CK AF Blyth, Dana M. Chung, Kevin K. Cancio, Leopoldo C. King, Booker T. Murray, Clinton K. TI Clinical utility of fungal screening assays in adults with severe burns SO BURNS LA English DT Article DE Burn; Fungal infection; Serology; beta-Glucan; Galactomannan ID BETA-D-GLUCAN; INVASIVE ASPERGILLOSIS; WOUND-INFECTION; DIAGNOSIS; COLONIZATION; ANTIGENEMIA; CULTURE AB Background: Fungal wound infection is a leading cause of burn wound infections, and diagnosis is often delayed as it conventionally requires culture and histopathology. Fungal screening assays have sped diagnosis of invasive fungal infections in other populations. Few studies have evaluated the performance of fungal screening assays outside of the hematologic malignancy and hematopoietic stem cell transplant populations. Methods: We performed a three year retrospective analysis of all fungal screening assays in burn patients in the ICU between 2008 and 2011. The primary goal was to evaluate the correlation between the two available fungal screening assays, (1 -> 3)-beta-D-glucan (BG) and galactomannan (GM) assay, and fungal wound colonization (FWC) and infection (FWI). We also evaluated previously hypothesized causes of false positives and their associations with false positives in the burn population. Results: We identified 53 patients [median 29% total body surface area burned (TBSA), IQR 17-51] with BG or GM serological tests available, of which 15 had a FWI or FWC. FWC/FWI was associated with higher TBSA (p = 0.02). BG and GM correlated with TBSA (BG 0.57, p < 0.01; GM 0.35, p = 0.02), but neither assay was associated with FWI/FWC or species of fungus involved when FWI/FWC was diagnosed. Conclusions: Positive BG and GM fungal screening assays are not associated with FWI/FWC, or with species of fungus when FWC/FWI is present. BG false positives are common and associated with higher TBSA burns. Published by Elsevier Ltd and ISBI C1 [Blyth, Dana M.; Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Houston, TX 78234 USA. [Chung, Kevin K.; Cancio, Leopoldo C.; King, Booker T.] USA, Inst Surg Res, Houston, TX 78234 USA. [Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr, Houston, TX 78234 USA. EM clinton.murray@us.army.mil OI Blyth, Dana/0000-0002-3917-7394 NR 19 TC 3 Z9 3 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD MAY PY 2013 VL 39 IS 3 BP 413 EP 419 DI 10.1016/j.burns.2012.08.009 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 118KX UT WOS:000317025500006 PM 22999208 ER PT J AU Rizzo, JA Burgess, P Cartie, RJ Prasad, BM AF Rizzo, Julie A. Burgess, Pamela Cartie, Richard J. Prasad, Balakrishna M. TI Moderate systemic hypothermia decreases burn depth progression SO BURNS LA English DT Article DE Therapeutic hypothermia; Burn progression; Matrix metalloprotease; Inflammation; Microarray ID THERAPEUTIC HYPOTHERMIA; THERMAL-INJURY; MATRIX METALLOPROTEINASES; INFLAMMATORY RESPONSE; PROFOUND HYPOTHERMIA; CEREBRAL-ISCHEMIA; LETHAL HEMORRHAGE; MILD HYPOTHERMIA; UP-REGULATION; BRAIN-INJURY AB Background: Therapeutic hypothermia has been proposed to be beneficial in an array of human pathologies including cardiac arrest, stroke, traumatic brain and spinal cord injury, and hemorrhagic shock. Burn depth progression is multifactorial but inflammation plays a large role. Because hypothermia is known to reduce inflammation, we hypothesized that moderate hypothermia will decrease burn depth progression. Methods: We used a second-degree 15% total body surface area thermal injury model in rats. Burn depth was assessed by histology of biopsy sections. Moderate hypothermia in the range of 31-33 degrees C was applied for 4 h immediately after burn and in a delayed fashion, starting 2 h after burn. In order to gain insight into the beneficial effects of hypothermia, we analyzed global gene expression in the burned skin. Results: Immediate hypothermia decreased burn depth progression at 6 h post injury, and this protective effect was sustained for at least 24 h. Burn depth was 18% lower in rats subjected to immediate hypothermia compared to control rats at both 6 and 24 h post injury. Rats in the delayed hypothermia group did not show any significant decrease in burn depth at 6 h, but had 23% lower burn depth than controls at 24 h. Increased expression of several skin-protective genes such as CCL4, CCL6 and CXCL13 and decreased expression of tissue remodeling genes such as matrix metalloprotease-9 were discovered in the skin biopsy samples of rats subjected to immediate hypothermia. Conclusions: Systemic hypothermia decreases burn depth progression in a rodent model and up-regulation of skin-protective genes and down-regulation of detrimental tissue remodeling genes by hypothermia may contribute to its beneficial effects. Published by Elsevier Ltd and ISBI C1 [Rizzo, Julie A.; Burgess, Pamela; Cartie, Richard J.; Prasad, Balakrishna M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Rizzo, JA (reprint author), MCHF SCL GSS, Ft Gordon, GA 30905 USA. EM julie.rizzo@us.army.mil; pamela.burgess@us.army.mil; rcartie@hotmail.com; balakrishna.prasad@us.army.mil NR 43 TC 5 Z9 5 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD MAY PY 2013 VL 39 IS 3 BP 436 EP 444 DI 10.1016/j.burns.2012.07.022 PG 9 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 118KX UT WOS:000317025500009 PM 23149435 ER PT J AU Richard, R Dewey, S Parry, I Jones, J AF Richard, Reg Dewey, Scott Parry, Ingrid Jones, John TI Untitled SO BURNS LA English DT Letter ID CONTRACTURES; MANAGEMENT C1 [Richard, Reg; Dewey, Scott; Jones, John] USA, Inst Surg Res, Burn Ctr, San Antonio, TX USA. [Parry, Ingrid] Shriners Hosp Children Northern Calif, Sacramento, CA USA. RP Richard, R (reprint author), USA, Inst Surg Res, ATTN MCMR SRT T Richard, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM reginald.richard@amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD MAY PY 2013 VL 39 IS 3 BP 539 EP 541 DI 10.1016/j.burns.2012.07.032 PG 3 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 118KX UT WOS:000317025500033 PM 23107355 ER PT J AU Romero-Zurita, N McLernon, D Ghogho, M Swami, A AF Romero-Zurita, Nabil McLernon, Des Ghogho, Mounir Swami, Ananthram TI PHY Layer Security Based on Protected Zone and Artificial Noise SO IEEE SIGNAL PROCESSING LETTERS LA English DT Article DE Artificial noise; beamforming; outage probability; passive eavesdropping; physical layer security; protected zone; secrecy rate; wireless secrecy AB We address physical layer security in multiple-input-multiple-output (MISO) communications in the presence of an unknown passive eavesdropper. Beamforming and artificial noise broadcasting are chosen to increase communications security. We first study the effect of a close eavesdropper on security and then we define a "Protected Zone" in the transmitter's vicinity. We present an optimisation strategy that intelligently sets the transmission power and the size of the protected zone to probabilistically achieve secrecy at a specified target secrecy rate. The results show that this strategy can achieve a high probability of secrecy by efficiently prioritising the use of the available resources. C1 [Romero-Zurita, Nabil; McLernon, Des; Ghogho, Mounir] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. [Ghogho, Mounir] Int Univ Rabat, Rabat, Morocco. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Romero-Zurita, N (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. EM el08lnrz@leeds.ac.uk; d.c.mclernon@leeds.ac.uk; m.ghogho@leeds.ac.uk; a.swami@ieee.org RI Romero-Zurita, Nabil/E-5790-2012 OI Romero-Zurita, Nabil/0000-0002-0060-3122 NR 7 TC 19 Z9 21 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9908 J9 IEEE SIGNAL PROC LET JI IEEE Signal Process. Lett. PD MAY PY 2013 VL 20 IS 5 BP 487 EP 490 DI 10.1109/LSP.2013.2252898 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA 118FA UT WOS:000317007600001 ER PT J AU Shih, TM Koplovitz, I McDonough, JH Myers, TM Kan, RK AF Shih, T. M. Koplovitz, I. McDonough, J. H. Myers, T. M. Kan, R. K. TI Tertiary oximes on acetylcholinesterase activity, survival, and neurobehavioral consequences following nerve agent exposure SO JOURNAL OF NEUROCHEMISTRY LA English DT Meeting Abstract CT 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry CY APR 20-24, 2013 CL Cancun, MEXICO SP Int Soc Neurochemistry, Amer Soc Neurochemistry C1 [Shih, T. M.; Koplovitz, I.; McDonough, J. H.; Myers, T. M.; Kan, R. K.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD MAY PY 2013 VL 125 SU 1 SI SI BP 272 EP 273 PG 2 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 117OB UT WOS:000316961700640 ER PT J AU Gao, XG Lin, HL Ray, R Ray, P AF Gao, Xiugong Lin, Hsiuling Ray, Radharaman Ray, Prabhati TI Toxicogenomic Studies of Human Neural Cells Following Exposure to Organophosphorus Chemical Warfare Nerve Agent VX SO NEUROCHEMICAL RESEARCH LA English DT Article DE Organophosphorus compound; Chemical warfare agent; Nerve agent; VX; Neural cells; Neurotoxicity; Microarray ID HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; GENE-EXPRESSION; IMMUNOLOGICAL ABNORMALITIES; NEUROTROPHIC FACTOR; REDUCED EXPRESSION; SIGNALING PATHWAY; SEMAPHORIN 3A; BRAIN; SCHIZOPHRENIA AB Organophosphorus (OP) compounds represent an important group of chemical warfare nerve agents that remains a significant and constant military and civilian threat. OP compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Many studies over the past years have suggested that other mechanisms of OP toxicity exist, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. Here we performed a microarray study in which cultured human neural cells were exposed to 0.1 or 10 mu M of VX for 1 h. Global gene expression changes were analyzed 6, 24, and 72 h post exposure. Functional annotation and pathway analysis of the differentially expressed genes has revealed many genes, networks and canonical pathways that are related to nervous system development and function, or to neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease. In particular, the neuregulin pathway impacted by VX exposure has important implications in many nervous system diseases including schizophrenia. These results provide useful information valuable in developing suitable antidotes for more effective prevention and treatment of, as well as in developing biomarkers for, VX-induced chronic neurotoxicity. C1 [Gao, Xiugong; Lin, Hsiuling; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Ray, Radharaman] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xiugong.gao@amedd.army.mil; hsiuling.lin@us.army.mil; radharman.ray@us.army.mil; prabhati.ray@us.army.mil FU Defense Threat Reduction Agency (DTRA) [CBS.MEDCHEM.01.10.WR.005] FX We thank Dr. Maryanne T. Vahey and her staff of the WRAIR Vaccine Genomics Laboratory (Rockville, MD), Mr. Martin E. Nau and Dr. Zhining Wang, for their kind help in performing the microarray experiments and providing the raw data. We also thank Ms. Betty J. Benton and Dr. Brian M Keyser at USAMRICD for their help with VX exposure, and Mr. Jack Amnuaysirikul at WRAIR for his help with RNA sample preparation. This work was supported by the Defense Threat Reduction Agency (DTRA) Project No. CBS.MEDCHEM.01.10.WR.005. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the US Army or the Department of Defense. NR 81 TC 1 Z9 1 U1 2 U2 44 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-3190 J9 NEUROCHEM RES JI Neurochem. Res. PD MAY PY 2013 VL 38 IS 5 BP 916 EP 934 DI 10.1007/s11064-013-0996-1 PG 19 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 116SO UT WOS:000316903200003 PM 23440544 ER PT J AU Bessho, T Morii, S Kusumoto, T Shinohara, T Noda, M Uchiyama, S Shuto, S Nishimura, S Djikeng, A Duszenko, M Martin, SK Inui, T Kubata, KB AF Bessho, Tomoaki Morii, Shoko Kusumoto, Toshihide Shinohara, Takahiro Noda, Masanori Uchiyama, Susumu Shuto, Satoshi Nishimura, Shigenori Djikeng, Appolinaire Duszenko, Michael Martin, Samuel K. Inui, Takashi Kubata, Kilunga B. TI Characterization of the novel Trypanosoma brucei inosine 5 '-monophosphate dehydrogenase SO PARASITOLOGY LA English DT Article DE trypanosome; enzyme kinetics; enzyme inhibitor; nucleoside nucleotide analogues; drug design ID HUMAN AFRICAN TRYPANOSOMIASIS; TRANSITION-STATE ANALOG; HEPATITIS-C VIRUS; MONOPHOSPHATE DEHYDROGENASE; TRITRICHOMONAS-FETUS; IMP DEHYDROGENASE; CRYSTAL-STRUCTURE; ANTIVIRAL ACTIVITY; KINETIC MECHANISM; DRUG DESIGN AB There is an alarming rate of human African trypanosomiasis recrudescence in many parts of sub-Saharan Africa. Yet, the disease has no successful chemotherapy. Trypanosoma lacks the enzymatic machinery for the de novo synthesis of purine nucleotides, and is critically dependent on salvage mechanisms. Inosine 5'-monophosphate dehydrogenase (IMPDH) is responsible for the rate-limiting step in guanine nucleotide metabolism. Here, we characterize recombinant Trypanosoma brucei IMPDH (TbIMPDH) to investigate the enzymatic differences between TbIMPDH and host IMPDH. Size-exclusion chromatography and analytical ultracentrifugation sedimentation velocity experiments reveal that TbIMPDH forms a heptamer, different from type 1 and 2 mammalian tetrameric IMPDHs. Kinetic analysis reveals calculated K-m values of 30 and 1300 mu M for IMP and NAD, respectively. The obtained K-m value of TbIMPDH for NAD is approximately 20-200-fold higher than that of mammalian enzymes and indicative of a different NAD binding mode between trypanosomal and mammalian IMPDHs. Inhibition studies show K-i values of 3.2 mu M, 21 nM and 3.3 nM for ribavirin 5'-monophosphate, mycophenolic acid and mizoribine 5'-monophosphate, respectively. Our results show that TbIMPDH is different from its mammalian counterpart and thus may be a good target for further studies on anti-trypanosomal drugs. C1 [Bessho, Tomoaki; Morii, Shoko; Kusumoto, Toshihide; Shinohara, Takahiro; Nishimura, Shigenori; Inui, Takashi] Osaka Prefecture Univ, Lab Biol Macromol, Grad Sch Life & Environm Sci, Naka Ku, Sakai, Osaka 5998531, Japan. [Noda, Masanori; Uchiyama, Susumu] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan. [Shuto, Satoshi] Hokkaido Univ, Fac Pharmaceut Sci, Lab Organ Chem Drug Dev, Kita Ku, Sapporo, Hokkaido 0600812, Japan. [Djikeng, Appolinaire] Int Livestock Res Inst ILRI, Biosci Eastern & Cent Africa BecA Hub, Nairobi, Kenya. [Djikeng, Appolinaire] JCVI, Rockville, MD 20876 USA. [Duszenko, Michael] Univ Tubingen, Interfac Inst Biochem, D-72076 Tubingen, Germany. [Martin, Samuel K.] USA, Med Res Unit Kenya, Unit 64109, APO, AE 09831 USA. [Kubata, Kilunga B.] AU NEPAD Agcy Reg Off Eastern & Cent Africa, Nairobi, Kenya. RP Inui, T (reprint author), Osaka Prefecture Univ, Lab Biol Macromol, Grad Sch Life & Environm Sci, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan. EM inuit@bioinfo.osakafu-u.ac.jp; bkkubata@nepadst.org RI Inui, Takashi/G-1069-2011 FU Government of Canada through the Canadian International Development Agency; Ministry of Education, Culture, Sports, Science and Technology of Japan; Osaka Prefecture [17300165, 21500428, 21200076] FX We thank Dr K. Fujimori, Ms M. Tabuchi and Ms C. Kimura for technical assistance and helpful discussions. This study was undertaken with the financial support of the Government of Canada provided through the Canadian International Development Agency to NEPAD. This study was also supported in part by the program Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan and Osaka Prefecture (grant numbers 17300165, 21500428 and 21200076 (to T.I.)). NR 51 TC 3 Z9 3 U1 1 U2 20 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0031-1820 EI 1469-8161 J9 PARASITOLOGY JI Parasitology PD MAY PY 2013 VL 140 IS 6 BP 735 EP 745 DI 10.1017/S0031182012002090 PG 11 WC Parasitology SC Parasitology GA 115MJ UT WOS:000316816000007 PM 23369253 ER PT J AU Hollingshad, NW Svenkeson, A West, BJ Grigolini, P AF Hollingshad, Nicholas W. Svenkeson, Adam West, Bruce J. Grigolini, Paolo TI Time to consensus SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Networks; Criticality; First passage time; Complex systems; Decision-making ID CRITICALITY; NETWORKS; MODEL AB The dynamics of a two-state decision-making model (DMM) with a tunable control parameter K is described. On all-to-all (ATA) networks, the system undergoes a phase transition at a critical value of K-c = 1. Scale-free networks were also found to undergo phase transitions, but the value of K-c increases as the scale-free exponent increases. Time to consensus is defined as a first passage time to a specified threshold of the global mean field, which represents a level of majority for the network. At criticality, the time to consensus for sparse networks with broad degree distributions (e.g., scale-free networks) approaches that of the ATA networks, although somewhat more cooperation (higher K-c) is required. (C) 2013 Elsevier B.V. All rights reserved. C1 [Hollingshad, Nicholas W.; Svenkeson, Adam; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC 27709 USA. RP Hollingshad, NW (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. EM nhollingshad@verizon.net FU ARO [W911NF1110478]; Welch [B-1577] FX N. W. Hollingshad, A. Svenkeson and P. Grigolini warmly thank ARO and Welch for financial support through Grants W911NF1110478 and B-1577, respectively. NR 25 TC 2 Z9 2 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD MAY 1 PY 2013 VL 392 IS 9 BP 2302 EP 2310 DI 10.1016/j.physa.2013.01.037 PG 9 WC Physics, Multidisciplinary SC Physics GA 114WX UT WOS:000316774800039 ER PT J AU Coppock, M Farrow, B Finch, AS Lai, B Maciel, J Heath, J Stratis-Cullum, DN AF Coppock, M. Farrow, B. Finch, A. S. Lai, B. Maciel, J. Heath, J. Stratis-Cullum, D. N. TI Protein Capture Agents with High Affinity, Selectivity, and Stability for Improving BioDetection Assays SO BIOPOLYMERS LA English DT Meeting Abstract CT 23rd American Peptide Symposium CY JUN 22-27, 2013 CL Waikoloa, HI C1 [Coppock, M.; Finch, A. S.; Stratis-Cullum, D. N.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Farrow, B.; Heath, J.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA. [Lai, B.] Integrated Diagnost, Culver City, CA 90230 USA. [Maciel, J.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 1 Z9 1 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0006-3525 EI 1097-0282 J9 BIOPOLYMERS JI Biopolymers PD MAY PY 2013 VL 100 IS 3 SI SI BP 289 EP 289 PG 1 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AI0IL UT WOS:000336530200237 ER PT J AU Gaidamakova, E Myles, I McDaniel, D Gayen, M Gupta, P Sharma, A Glass, P Maheshwari, R Datta, S Daly, MJ AF Gaidamakova, Elena Myles, Ian McDaniel, Dennis Gayen, Manoshi Gupta, Paridhi Sharma, Anuj Glass, Pamela Maheshwari, Radha Datta, Sandip Daly, Michael J. TI Applying a Radioprotective Mn(II)-peptide-Pi Complex to the Preparation of Irradiated Vaccines SO BIOPOLYMERS LA English DT Meeting Abstract CT 23rd American Peptide Symposium CY JUN 22-27, 2013 CL Waikoloa, HI C1 [Gaidamakova, Elena; McDaniel, Dennis; Gayen, Manoshi; Gupta, Paridhi; Sharma, Anuj; Maheshwari, Radha; Daly, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Myles, Ian; Datta, Sandip] NIAID, Bethesda, MD 20892 USA. [Glass, Pamela] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0006-3525 EI 1097-0282 J9 BIOPOLYMERS JI Biopolymers PD MAY PY 2013 VL 100 IS 3 SI SI BP 297 EP 297 PG 1 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AI0IL UT WOS:000336530200269 ER PT J AU Tannheimer, M Buzzelli, MD Albertini, N Lechner, R Ulmer, HV Engelhardt, M AF Tannheimer, Markus Buzzelli, Mark D. Albertini, Nadine Lechner, Raimund Ulmer, Hans-V Engelhardt, Michael TI Improvement in Altitude Performance Test After Further Acclimatization in Pre-Acclimatized Soldiers SO MILITARY MEDICINE LA English DT Article AB The Altitude Performance Test is a measure designed to assess an individual's degree of acclimatization to reduce the risk of acute mountain sickness during high-altitude activities. The aim of this study was to investigate the hypothesis that test results will improve in pre-acclimatized soldiers after several days of further acclimatization. The Altitude Performance Test consists of an uphill run at high altitude. The event is timed and performed with continuous oxygen saturation (SpO(2)) monitoring. The individual's time and lowest SpO(2) measurement are recorded. This test was performed on the first day of arriving at 11,060 ft, and after 9 days at the same location. The 37 male soldiers were all pre-acclimatized before arrival. The sleeping altitude remained constant at 11,060 ft, and the daytime altitudes increased up to a maximum of 15,775 ft. Test results improved significantly after a further 9 days of acclimatization (time, -11 s; SpO(2), +5%-points; p <= 0.001). This is remarkable because all soldiers were pre-acclimatized and showed only minor acute mountain sickness symptoms during the entire stay. This indicates that the acclimatization process is not finished after amelioration of altitude symptoms. The demonstrated improvement in physical performance could prove very important, particularly during military missions performed at high altitude. C1 [Tannheimer, Markus] Armed Forces Hosp Ulm, Dept Visceral & Thorac Surg, D-89081 Ulm, Germany. [Buzzelli, Mark D.] Womack Army Med Ctr, Dept Gen Surg, Ft Bragg, NC 28307 USA. [Albertini, Nadine; Ulmer, Hans-V] Johannes Gutenberg Univ Mainz, Dept Sports Physiol, D-55099 Mainz, Germany. [Lechner, Raimund] Kommando Spezialkrafte, D-76365 Calw, Germany. [Engelhardt, Michael] Armed Forces Hosp Ulm, Dept Vasc Surg, D-89081 Ulm, Germany. RP Tannheimer, M (reprint author), Armed Forces Hosp Ulm, Dept Visceral & Thorac Surg, Oberer Eselsberg 40, D-89081 Ulm, Germany. NR 10 TC 1 Z9 1 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2013 VL 178 IS 5 BP 507 EP 510 DI 10.7205/MILMED-D-12-00410 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V39YX UT WOS:000209447400007 PM 23756008 ER PT J AU Holland, SR Apodaca, A Mabry, RL AF Holland, Seth R. Apodaca, Amy Mabry, Robert L. TI MEDEVAC: Survival and Physiological Parameters Improved With Higher Level of Flight Medic Training SO MILITARY MEDICINE LA English DT Article AB Objective: Determine if a higher level of Army flight medic (AFM) training was associated with improved physiological state on arrival to a combat support hospital (CSH). Methods: A retrospective study comparing casualties who were evacuated by two AFM units with only Emergency Medical Technicians-Basic (EMT-Bs) to an Army National Guard unit with Critical Care Flight Paramedics (CCFPs) in Afghanistan with an injury severity score >16 in different time periods looking at their 48-hour mortality, hematocrit (HCT), base deficit (BD), oxygen saturation (SpO(2)), and physiological parameters on arrival to the CSH. Results: The CCFP group had better HCT [36.5 (8.8)] than the EMT-B group [33.1 (11.4); p <= 0.001]. BD and SpO(2) were better in the CCFP group [-3.2 (4.7)]/[97.8 (4.8)] than the EMT-B group [-4.4 (5.5)]/[96.3 (10.9)] [p <= 0.014]. The CCFP group had a 72% lower estimated risk ratio of mortality with an associated improvement in 48-hour survivability of 4.9% versus 15.8% for the EMT-B-group. Conclusions: There is a statistically significant improvement in the HCT, BD, SpO(2), and 48-hour survivability at the CSH in the cohort transported by the CCFP group when compared to the cohort transported by the EMT-B group. C1 [Holland, Seth R.; Apodaca, Amy; Mabry, Robert L.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Holland, SR (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 43 TC 3 Z9 3 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2013 VL 178 IS 5 BP 529 EP 536 DI 10.7205/MILMED-D-12-00286 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA V39YX UT WOS:000209447400011 PM 23756012 ER PT J AU Srinivas, U Chen, Y Monga, V Nasrabadi, NM Tran, TD AF Srinivas, Umamahesh Chen, Yi Monga, Vishal Nasrabadi, Nasser M. Tran, Trac D. TI Exploiting Sparsity in Hyperspectral Image Classification via Graphical Models SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Classification; hyperspectral imagery; joint sparsity model; probabilistic graphical models; sparse representation; spatial correlation ID REMOTE-SENSING IMAGES AB A significant recent advance in hyperspectral image (HSI) classification relies on the observation that the spectral signature of a pixel can be represented by a sparse linear combination of training spectra from an overcomplete dictionary. A spatiospectral notion of sparsity is further captured by developing a joint sparsity model, wherein spectral signatures of pixels in a local spatial neighborhood (of the pixel of interest) are constrained to be represented by a common collection of training spectra, albeit with different weights. A challenging open problem is to effectively capture the class conditional correlations between these multiple sparse representations corresponding to different pixels in the spatial neighborhood. We propose a probabilistic graphical model framework to explicitly mine the conditional dependences between these distinct sparse features. Our graphical models are synthesized using simple tree structures which can be discriminatively learnt (even with limited training samples) for classification. Experiments on benchmark HSI data sets reveal significant improvements over existing approaches in classification rates as well as robustness to choice of training. C1 [Srinivas, Umamahesh; Monga, Vishal] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Srinivas, U (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM uxs113@psu.edu; ychen98@jhu.edu; vmonga@engr.psu.edu; nnasraba@arl.army.mil; trac@jhu.edu FU National Science Foundation [CCF-1117545, CCF-0728893]; Army Research Office [58110-MA-II, 60219-MA]; Office of Naval Research [N102-183-0208] FX This work was supported in part by the National Science Foundation under Grants CCF-1117545 and CCF-0728893, by the Army Research Office under Grants 58110-MA-II and 60219-MA, and by the Office of Naval Research under Grant N102-183-0208. NR 22 TC 34 Z9 36 U1 2 U2 61 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD MAY PY 2013 VL 10 IS 3 BP 505 EP 509 DI 10.1109/LGRS.2012.2211858 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 046YX UT WOS:000311802900019 ER PT J AU Ballard, JR Howington, SE Wilhelms, SC AF Ballard, Jerrell R., Jr. Howington, Stacy E. Wilhelms, Steven C. TI Laboratory-Based Rainfall Effects on LWIR Soil Reflectance SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Disturbed soil; long-wave infrared (LWIR) soil reflectance; rainfall ID INFRARED MEASUREMENTS; EMISSIVITY; FIELD; TEMPERATURE; PRISTINE; SPECTRA AB The long-wave infrared reflectance of in situ disturbed and undisturbed soils will often have distinct spectral characteristics that are dependent on the soil's physical and spectral constitutive properties. This study examines how rainfall alters the measured directional-hemispherical thermal infrared (8-14 mu m) spectral reflectance of a disturbed soil with a specified sand/silt ratio using a calibrated rainfall simulator. For an accumulated rainfall of 8.0 cm, the mean disturbed soil thermal infrared spectral reflectance within 8.1-9.2-mu m waveband increases from an initial reflectance of 13% to a maximum reflectance of 31%. Sixty percent of this reflectance change occurred with only 1.0-cm accumulated rainfall. This study shows that, for this described disturbed sand/silt soil mixture, small accumulated rainfall amounts significantly alter the directional-hemispherical thermal infrared spectral reflectance. C1 [Ballard, Jerrell R., Jr.] USA, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Howington, Stacy E.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wilhelms, Steven C.] Bowhead Sci & Technol Inc, Vicksburg, MS 39180 USA. RP Ballard, JR (reprint author), USA, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM jerry.ballard@us.army.mil; stacy.e.howington@usace.army.mil; steven.c.wilhelms@erdc.dren.mil FU U.S. Army Engineer Research and Development Center under the Military Engineering Basic Research Program FX This work was supported by the U.S. Army Engineer Research and Development Center under the Military Engineering Basic Research Program. NR 15 TC 2 Z9 2 U1 0 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD MAY PY 2013 VL 10 IS 3 BP 627 EP 630 DI 10.1109/LGRS.2012.2216250 PG 4 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 046YX UT WOS:000311802900044 ER PT J AU Lewis, JA Gehman, EA Baer, CE Jackson, DA AF Lewis, John A. Gehman, Elizabeth A. Baer, Christine E. Jackson, David A. TI Alterations in gene expression in Caenorhabditis elegans associated with organophosphate pesticide intoxication and recovery SO BMC GENOMICS LA English DT Article DE Caenorhabditis elegans; Organophosphate pesticide intoxication; Gene expression; Dichlorvos; Acetylcholinesterase inhibition; Mitochondrial disruption; Dichlorvos-induced developmental delay ID AXON REGENERATION REQUIRES; TRANSCRIPTION FACTOR; INNATE IMMUNITY; C-ELEGANS; SIGNALING PATHWAY; OXIDATIVE STRESS; KINASE PATHWAY; MAP KINASE; LIFE-SPAN; LONGEVITY AB Background: The principal toxicity of acute organophosphate (OP) pesticide poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis elegans is relatively resistant to OP lethality-particularly through the inhibition of AChE-studies in this nematode provide an opportunity to observe alterations in global gene expression following OP exposure that cannot be readily observed in less resistant organisms. Results: We exposed cultures of worms in axenic, defined medium to dichlorvos under three exposure protocols. In the first, worms were exposed continuously throughout the experiment. In the second and third, the worms were exposed for either 2 or 8 h, the dichlorvos was washed out of the culture, and the worms were allowed to recover. We then analyzed gene expression using whole genome microarrays from RNA obtained from worms sampled at multiple time points throughout the exposure. The worms showed a time-dependent increase in the expression of genes involved in stress responses. Early in the exposure, the predominant effect was on metabolic processes, while at later times, an immune-like response and cellular repair mechanisms dominated the expression pattern. Following removal of dichlorvos, the gene expression in the worms appeared to relatively rapidly return to steady-state levels. Conclusion: The changes in gene expression observed in the worms following exposure to dichlorvos point towards two potential mechanisms of toxicity: inhibition of AChE and mitochondrial disruption. C1 [Lewis, John A.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Baer, Christine E.] Excet Inc, Ft Detrick, MD USA. RP Lewis, JA (reprint author), USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. EM john.a.lewis1@us.army.mi RI Jackson, David/E-9984-2014 FU Alan Rosencrance for quantitative analysis of dichlorvos stocks and media; Army Independent Laboratory Innovative Research award; Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command FX The authors and the US Army Center for Environmental Health Research wish to thank the following individuals for their support and assistance: Debbie French for testing CeHR medium; Martin Nau and other members of Dr. Maryanne Vahey's laboratory for microarray processing; Dr. Maryanne Vahey, of the Division of Retrovirology, Walter Reed Army Institute of Research for very generous research support; Alan Rosencrance for quantitative analysis of dichlorvos stocks and media. The research was supported in part by an Army Independent Laboratory Innovative Research award to DAJ and JAL and by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. Citations of commercial organizations or trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. NR 68 TC 7 Z9 7 U1 2 U2 34 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD APR 30 PY 2013 VL 14 AR 291 DI 10.1186/1471-2164-14-291 PG 17 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 150RB UT WOS:000319407400001 PM 23631360 ER PT J AU Xie, JQ Mita, S Bryan, Z Guo, W Hussey, L Moody, B Schlesser, R Kirste, R Gerhold, M Collazo, R Sitar, Z AF Xie, Jinqiao Mita, Seiji Bryan, Zachary Guo, Wei Hussey, Lindsay Moody, Baxter Schlesser, Raoul Kirste, Ronny Gerhold, Michael Collazo, Ramon Sitar, Zlatko TI Lasing and longitudinal cavity modes in photo-pumped deep ultraviolet AlGaN heterostructures SO APPLIED PHYSICS LETTERS LA English DT Article ID LIGHT-EMITTING-DIODES; QUANTUM-WELL LASER; ALN; GROWTH; GAN; NM AB To unambiguously distinguish lasing from super luminescence, key elements of lasing such as longitudinal cavity modes with narrow line-width, polarized emission, and elliptically shaped far-field pattern, need to be demonstrated at the same time. Here, we show transverse electric polarized lasing at 280.8 nm and 263.9 nm for AlGaN based multi-quantum-wells and double heterojunction structures fabricated on single crystalline AlN substrates. An elliptically shaped far-field pattern was recorded when pumped above threshold. With cavities shorter than 200 mu m, well-defined, equally spaced longitudinal modes with line widths as narrow as 0.014 nm were observed. The low threshold pumping density of 84kW/cm(2) suggests that the electrically pumped sub-300 nm ultraviolet laser diodes are imminent. (C) 2013 AIP Publishing LLC. C1 [Xie, Jinqiao; Mita, Seiji; Moody, Baxter; Schlesser, Raoul] HexaTech Inc, Morrisville, NC 27560 USA. [Bryan, Zachary; Guo, Wei; Hussey, Lindsay; Kirste, Ronny; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Xie, JQ (reprint author), HexaTech Inc, 991 Aviat Pkwy,Suite 800, Morrisville, NC 27560 USA. EM axie@hexatechinc.com NR 23 TC 43 Z9 43 U1 3 U2 43 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 29 PY 2013 VL 102 IS 17 AR 171102 DI 10.1063/1.4803689 PG 4 WC Physics, Applied SC Physics GA 139AG UT WOS:000318553000002 ER PT J AU Sliozberg, YR Mrozek, RA Schieber, JD Kroger, M Lenhart, JL Andzelm, JW AF Sliozberg, Yelena R. Mrozek, Randy A. Schieber, Jay D. Kroeger, Martin Lenhart, Joseph L. Andzelm, Jan W. TI Effect of polymer solvent on the mechanical properties of entangled polymer gels: Coarse-grained molecular simulation SO POLYMER LA English DT Article DE Polymer; Modeling; Entanglements ID DISSIPATIVE PARTICLE DYNAMICS; CONSTANT STRAIN; MELTS; NETWORKS; RHEOLOGY; STRESS; EQUILIBRATION; PERFORMANCE; HYDROGELS; SYSTEMS AB Polymer gels are composed of a chemically or physically cross-linked polymer that is highly swollen with solvent. Two important limitations for the practical application of polymer gels are low toughness and a limited ability to tailor the strain-rate dependent mechanical response. Both these limitations are due to the high loadings of small molecule solvents that are typically incorporated into the gel formulation. Here, we provide insight into the role of physical entanglements on the performance of polymer gels, when the solvent molecular weight is large enough to entangle with the polymer network. Our simulations demonstrate that the solvent entanglements dominate the time-dependent elastic modulus of polymer gels with high-molecular-weight solvent. We have found that entanglement contribution to the modulus is essentially equal for the entangled polymer melt and loosely cross-linked entangled polymer gel at high strain rate. At lower strain rate, the modulus of the polymer gels develops a long-lived plateau that originates from "semi-trapped" entanglements formed between network strands and polymer solvent. The simulations were validated with selected experiments of chemically cross-linked polydimethylsiloxane (PDMS) elastomers loaded with a non-reactive silicone oil solvent, where the solvent molecular weight was varied. The simulations and experimental results demonstrate that highly entangled solvent can be used to tune the rate dependent modulus of polymer gels. Published by Elsevier Ltd. C1 [Sliozberg, Yelena R.; Mrozek, Randy A.; Lenhart, Joseph L.; Andzelm, Jan W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Schieber, Jay D.] IIT, Dept Chem & Biol Engn, Chicago, IL 60616 USA. [Schieber, Jay D.] IIT, Dept Phys, Chicago, IL 60616 USA. [Schieber, Jay D.] IIT, Ctr Mol Study Condensed Soft Matter, Chicago, IL 60616 USA. [Kroeger, Martin] ETH, Dept Mat, CH-8093 Zurich, Switzerland. RP Andzelm, JW (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jan.w.andzelm.civ@mail.mil RI Schieber, Jay/F-9293-2012; Kroger, Martin/C-1946-2008 OI Schieber, Jay/0000-0002-9644-5236; Kroger, Martin/0000-0003-1402-6714 FU US Army Research Laboratory Enterprise for Multi-scale Research of Materials; Army Research Office [W911NF-08-2-0058, W911NF-09-2-0071]; Postgraduate Research Participation Program at the US Army Research Laboratory (ARL) FX This work was partially funded by the US Army Research Laboratory Enterprise for Multi-scale Research of Materials. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Research Laboratory (ARL), administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and ARL. Support to JDS by Army Research Office Grants W911NF-08-2-0058 and W911NF-09-2-0071 are gratefully acknowledged. We are grateful to Timothy W. Sirk and Tanya L Chantawansri for productive discussion. NR 55 TC 16 Z9 16 U1 5 U2 99 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD APR 26 PY 2013 VL 54 IS 10 BP 2555 EP 2564 DI 10.1016/j.polymer.2013.03.017 PG 10 WC Polymer Science SC Polymer Science GA 133LD UT WOS:000318139000011 ER PT J AU Taylor, DE AF Taylor, DeCarlos E. TI Intermolecular Forces and Molecular Dynamics Simulation of 1,3,5-Triamino-2,4,6-trinitrobenzene (TATB) Using Symmetry Adapted Perturbation Theory SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID KOHN-SHAM ORBITALS; CRYSTAL-STRUCTURE; AB-INITIO; FIELD; DENSITY; COMPRESSION; ENERGIES; MONOMERS; REAXFF; STATE AB The dimer potential energy surface (PES) of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) has been explored using symmetry adapted perturbation theory based on a Kohn-Sham density functional theory description of the monomers [SAPT(DFT)]. An intermolecular potential energy function was parametrized using a grid of 880 ab initio SAPT(DFT) dimer interaction energies, and the function was used to identify stationary points on the SAPT(DFT) dimer PES. It is shown that there exists a variety of minima with a range of bonding configurations and ab initio analyses of the interaction energy components, along with radial cross sections of the PES near each minimum, are presented. Results of isothermal-isostress molecular dynamics simulations are reported, and the simulated structure, thermal expansion, sublimation enthalpy, and bulk modulus of the TATB crystal, based on the SAPT(DFT) interaction potential, are in good agreement with experiment. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Taylor, DE (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.e.taylor.civ@mail.mil NR 44 TC 10 Z9 12 U1 5 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD APR 25 PY 2013 VL 117 IS 16 BP 3507 EP 3520 DI 10.1021/jp4005289 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 134LJ UT WOS:000318211400026 PM 23565605 ER PT J AU Baechle, DM Demaree, JD Hirvonen, JK Wetzel, ED AF Baechle, Daniel M. Demaree, John D. Hirvonen, James K. Wetzel, Eric D. TI Magnetron sputter deposition onto fluidized particle beds SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Fluidized bed; Sputter deposition; Microspheres; Optical film; Surface modification ID CHEMICAL-VAPOR-DEPOSITION; FILMS; MICROSPHERES; COMPOSITES; CATALYST; REACTOR; CVD AB A system for sputter deposition of thin (10-1000 nm) metal and ceramic coatings onto vibro-fluidized beds of millions of microparticles has been demonstrated. Coatings are sputtered onto microspheres of various size distributions. Experiments show that the coating deposition rate onto particles decreases with decreasing particle size, for the case of a fixed total bed mass. Factors affecting particle coating thickness also include sputter power and fluidized bed container size. Coating surface morphology is evaluated using scanning electron microscopy. Lower sputter deposition power creates smoother, less porous coatings. Fluidizing parameters, such as vibration amplitude and frequency, are also shown to affect coating morphology. Dual-layer metal-ceramic coatings are also demonstrated using the sputter deposition technique. A dual-layer aluminum/tin-oxide coating is produced on glass microspheres, which are then shown to have distinct reflectance characteristics and colors. A model is developed to estimate coating thickness based on size, shape and number of particles. Published by Elsevier B.V. C1 [Baechle, Daniel M.; Demaree, John D.; Hirvonen, James K.; Wetzel, Eric D.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Wetzel, ED (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM eric.d.wetzel2.civ@mail.mil NR 30 TC 1 Z9 1 U1 2 U2 15 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD APR 25 PY 2013 VL 221 BP 94 EP 103 DI 10.1016/j.surfcoat.2013.01.032 PG 10 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 131MT UT WOS:000317998500012 ER PT J AU Robinson, PD Kassu, A Sharma, A Kukhtareva, T Farley, CW Smith, C Ruffin, P Brantley, C Edwards, E AF Robinson, Paul David Kassu, Aschalew Sharma, Anup Kukhtareva, Tatiana Farley, Carlton William, III Smith, Cydale Ruffin, Paul Brantley, Christina Edwards, Eugene TI Surface-enhanced Raman spectroscopy scattering from gold-coated ceramic nanopore substrates: effect of nanopore size SO JOURNAL OF NANOPHOTONICS LA English DT Article DE surface-enhanced Raman spectroscopy; interparticle distance; anodic aluminum oxide; nanoporous membrane ID PLASMON RESONANCE; LIGHT; EXCITATION; DEPENDENCE; JUNCTIONS; MOLECULES; SILVER AB The dependence of magnitude of the electric near-field on the separation between metal nanoparticles for surface-enhanced Raman spectroscopy (SERS) substrates was experimentally verified. Diameters of gold-coated nanopores in a ceramic alumina substrate were varied to study the charge buildup near interparticle junctions and its effect on the enhancement factor due to SERS. The substrates were characterized by sensing a Rhodamine dye and calculating the associated Raman enhancement factors. Decreasing Au interparticle distance increases the electric near-field and shifts the plasmon resonance peak accordingly. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JNP.7.073592] C1 [Robinson, Paul David; Sharma, Anup; Kukhtareva, Tatiana; Farley, Carlton William, III] Alabama A&M Univ, Dept Phys Chem & Math, Normal, AL 35762 USA. [Kassu, Aschalew] Alabama A&M Univ, Dept Engn Construct Management & Ind Technol, Normal, AL 35762 USA. [Smith, Cydale] Alabama A&M Univ, Ctr Irradiat Mat, Normal, AL 35762 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Res Dev & Engn Command, Huntsville, AL 35898 USA. RP Robinson, PD (reprint author), Alabama A&M Univ, Dept Phys Chem & Math, 4900 Meridian St, Normal, AL 35762 USA. EM robinsonpaul82@yahoo.com FU U.S. Army RDECOM; Huntsville; Alabama [35898]; NSF-RISE; Alabama NSF-EPSCoR; NASA-EPSCoR [NNX12A109A]; NASA [NNX10AJ] FX This study was funded by U.S. Army RDECOM, Huntsville, Alabama 35898, NSF-RISE, Alabama NSF-EPSCoR, NASA-EPSCoR Grant NNX12A109A, and NASA Training Grant NNX10AJ. P. Robinson conducted SERS experiments and wrote the manuscript. A. Kassu helped edit the manuscript and conduct multiconcentration SERS measurements. A. Sharma helped write and edit the manuscript and originated the idea to use AAO nanopores. T. Kukhtareva helped with SEM, C. W. Farley conducted absorption measurements, and C. Smith helped deposit gold films. Dr. Ruffin, C. Brantley, and E. Edwards have been an integral part of the team in SERS experiments, editing the manuscript, involvement in various stages of planning and implementation, and they provided valuable inputs for the importance of this work for the Army. This work is part of P. Robinson's master's thesis, and A. Sharma and P. Ruffin served on his masters committee. NR 27 TC 3 Z9 3 U1 3 U2 59 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1934-2608 J9 J NANOPHOTONICS JI J. Nanophotonics PD APR 25 PY 2013 VL 7 AR 073592 DI 10.1117/1.JNP.7.073592 PG 9 WC Nanoscience & Nanotechnology; Optics SC Science & Technology - Other Topics; Optics GA 133NE UT WOS:000318144300001 ER PT J AU Lawhern, V Hairston, WD Robbins, K AF Lawhern, Vernon Hairston, W. David Robbins, Kay TI DETECT: A MATLAB Toolbox for Event Detection and Identification in Time Series, with Applications to Artifact Detection in EEG Signals SO PLOS ONE LA English DT Article ID INDEPENDENT COMPONENT ANALYSIS; CLASSIFICATION; SYSTEM AB Recent advances in sensor and recording technology have allowed scientists to acquire very large time-series datasets. Researchers often analyze these datasets in the context of events, which are intervals of time where the properties of the signal change relative to a baseline signal. We have developed DETECT, a MATLAB toolbox for detecting event time intervals in long, multi-channel time series. Our primary goal is to produce a toolbox that is simple for researchers to use, allowing them to quickly train a model on multiple classes of events, assess the accuracy of the model, and determine how closely the results agree with their own manual identification of events without requiring extensive programming knowledge or machine learning experience. As an illustration, we discuss application of the DETECT toolbox for detecting signal artifacts found in continuous multi-channel EEG recordings and show the functionality of the tools found in the toolbox. We also discuss the application of DETECT for identifying irregular heartbeat waveforms found in electrocardiogram ( ECG) data as an additional illustration. C1 [Lawhern, Vernon; Robbins, Kay] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. [Hairston, W. David] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Lawhern, V (reprint author), Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. EM Vernon.Lawhern@utsa.edu OI Hairston, W. David/0000-0003-4432-8430 FU Army Research Laboratory; [W911NF-10-2-0022] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 9 Z9 9 U1 2 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 24 PY 2013 VL 8 IS 4 AR e62944 DI 10.1371/journal.pone.0062944 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 136DE UT WOS:000318340400133 PM 23638169 ER PT J AU Propper, RE McGraw, SE Brunye, TT Weiss, M AF Propper, Ruth E. McGraw, Sean E. Brunye, Tad T. Weiss, Michael TI Getting a Grip on Memory: Unilateral Hand Clenching Alters Episodic Recall SO PLOS ONE LA English DT Article ID HEMISPHERIC ACTIVATION; AFFECTIVE STYLE; HANDEDNESS; EMOTION; CONTRACTION; ASYMMETRIES; EXPERIENCE; MUSCLES AB Unilateral hand clenching increases neuronal activity in the frontal lobe of the contralateral hemisphere. Such hand clenching is also associated with increased experiencing of a given hemisphere's "mode of processing.'' Together, these findings suggest that unilateral hand clenching can be used to test hypotheses concerning the specializations of the cerebral hemispheres during memory encoding and retrieval. We investigated this possibility by testing effects of unilateral hand clenching on episodic memory. The hemispheric Encoding/Retrieval Asymmetry (HERA) model proposes left prefrontal regions are associated with encoding, and right prefrontal regions with retrieval, of episodic memories. It was hypothesized that right hand clenching (left hemisphere activation) pre-encoding, and left hand clenching (right hemisphere activation) pre-recall, would result in superior memory. Results supported the HERA model. Also supported was that simple unilateral hand clenching can be used as a means by which the functional specializations of the cerebral hemispheres can be investigated in intact humans. C1 [Propper, Ruth E.; McGraw, Sean E.; Weiss, Michael] Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA. [Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA. EM propperr@mail.montclair.edu FU U.S. Army [W911QY-12-C-0046] FX Parts of this work were supported by U.S. Army contract #W911QY-12-C-0046 to author R.E.P. The opinions expressed herein are those of the authors and not necessarily of the US Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. NR 18 TC 5 Z9 5 U1 1 U2 42 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 24 PY 2013 VL 8 IS 4 AR e62474 DI 10.1371/journal.pone.0062474 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 136DE UT WOS:000318340400111 PM 23638094 ER PT J AU Rosch, TW Brennan, JK Izvekov, S Andzelm, JW AF Rosch, Thomas W. Brennan, John K. Izvekov, Sergei Andzelm, Jan W. TI Exploring the ability of a multiscale coarse-grained potential to describe the stress-strain response of glassy polystyrene SO PHYSICAL REVIEW E LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; POLYMER GLASSES; STEADY SHEAR; FORCE-FIELD; SIMULATIONS; SYSTEMS; DEFORMATION; TEMPERATURE; MECHANICS AB A new particle-based bottom-up method to develop coarse-grained models of polymers is presented and applied to polystyrene. The multiscale coarse-graining (MS-CG) technique of Izvekov et al. [J. Chem. Phys. 120, 10896 (2004)] is applied to a polymer system to calculate nonbonded interactions. The inverse Boltzmann inversion method was used to parametrize the bonded and bond-angle bending interactions. Molecular dynamics simulations were performed, and the CG model exhibited a significantly lower modulus compared to the atomistic model at low temperature and high strain rate. In an attempt to improve the CG model performance, several other parametrization schemes were used to build other models from this base model. The first of these models included standard frictional forces through use of the constant-temperature dissipative particle dynamics method that improved the modulus, yet was not transferrable to higher temperatures and lower strain rates. Other models were built by increasing the attraction between CG beads through direct manipulation of the nonbonded potential, where an improvement of the stress response was found. For these models, two parametrization protocols that shifted the force to more attractive values were explored. The first protocol involved a uniform shift, while the other protocol shifted the force in a more localized region. The uniformly shifted potential greatly affected the structure of the equilibrium model as compared to the locally shifted potential, yet was more transferrable to different temperatures and strain rates. Further improvements in the coarse-graining protocol to generate models that more satisfactorily capture mechanical properties are suggested. DOI:10.1103/PhysRevE.87.042606 C1 [Rosch, Thomas W.; Brennan, John K.; Izvekov, Sergei; Andzelm, Jan W.] Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Andzelm, JW (reprint author), Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jan.w.andzelm.civ@mail.mil FU US Army Research Laboratory Enterprise for Multi-Scale Research of Materials; US Army Research Laboratory FX This work was funded by the US Army Research Laboratory Enterprise for Multi-Scale Research of Materials. This research was supported in part by the Post-Graduate Research Participation Program at the US Army Research Laboratory administered by the Oak Ridge Institute for Science and Education. The authors would also like to acknowledge the help of Yelena Sliozberg (ARL) in generating the large CG systems and Craig Knox (US Army Edgewood Chemical Biological Center) for very useful LAMMPS scripts. NR 64 TC 10 Z9 10 U1 9 U2 62 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD APR 24 PY 2013 VL 87 IS 4 AR 042606 DI 10.1103/PhysRevE.87.042606 PG 14 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 131BX UT WOS:000317967300001 PM 23679442 ER PT J AU de Ceglia, D Campione, S Vincenti, MA Capolino, F Scalora, M AF de Ceglia, Domenico Campione, Salvatore Vincenti, Maria Antonietta Capolino, Filippo Scalora, Michael TI Low-damping epsilon-near-zero slabs: Nonlinear and nonlocal optical properties SO PHYSICAL REVIEW B LA English DT Article ID PSEUDO-BREWSTER ANGLE; ELECTROMAGNETIC ENHANCEMENT; PLASMONIC NANOSPHERES; METAMATERIAL SLAB; PERIODIC ARRAYS; NANOWIRE DIMERS; COMPLEX-MODES; LEAKY MODES; PERMITTIVITY; NANOPARTICLES AB We investigate second-harmonic generation, low-threshold multistability, all-optical switching, and inherently nonlocal effects due to the free-electron gas pressure in an epsilon-near-zero (ENZ) metamaterial slab made of cylindrical, plasmonic nanoshells illuminated by TM-polarized light. Damping compensation in the ENZ frequency region, achieved by using gain medium inside the nanoshells' dielectric cores, enhances the nonlinear properties. Reflection is inhibited, and the electric field component normal to the slab interface is enhanced near the effective pseudo-Brewster angle, where the effective e approximate to 0 condition triggers a nonresonant, impedance-matching phenomenon. We show that the slab displays a strong effective, spatial nonlocality associated with leaky modes that are mediated by the compensation of damping. The presence of these leaky modes then induces further spectral and angular conditions, where the local fields are enhanced, thus opening new windows of opportunity for the enhancement of nonlinear optical processes. DOI: 10.1103/PhysRevB.87.155140 C1 [de Ceglia, Domenico; Vincenti, Maria Antonietta] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Campione, Salvatore; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. [Scalora, Michael] USA, RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP de Ceglia, D (reprint author), Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM domenico.deceglia@us.army.mil RI Campione, Salvatore/A-2349-2015 OI Campione, Salvatore/0000-0003-4655-5485 FU National Research Council FX This research was performed while the authors M. A. Vincenti and D. de Ceglia held a National Research Council Research Associateship award at the US Army Aviation and Missile Research Development and Engineering Center. NR 76 TC 28 Z9 28 U1 3 U2 47 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD APR 22 PY 2013 VL 87 IS 15 DI 10.1103/PhysRevB.87.155140 PG 12 WC Physics, Condensed Matter SC Physics GA 129FG UT WOS:000317823800004 ER PT J AU Lemasson, BH Anderson, JJ Goodwin, RA AF Lemasson, Bertrand H. Anderson, James J. Goodwin, R. Andrew TI Motion-guided attention promotes adaptive communications during social navigation (vol 280, 20122003, 2013) SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Correction C1 [Goodwin, R. Andrew] USA, Environm Lab, Engineer Res & Dev Ctr, Portland, OR 97208 USA. NR 1 TC 0 Z9 0 U1 0 U2 10 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P ROY SOC B-BIOL SCI JI Proc. R. Soc. B-Biol. Sci. PD APR 22 PY 2013 VL 280 IS 1757 AR 20130304 DI 10.1098/rspb.2013.0304 PG 1 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA 103XV UT WOS:000315953700021 ER PT J AU Vakula, NI Kuramshina, GM Gorb, LG Hill, F Leszczynski, J AF Vakula, Nikita I. Kuramshina, Gulnara M. Gorb, Leonid G. Hill, Frances Leszczynski, Jerzy TI Adsorption and diffusion of a silver atom and its cation on alpha-SiO2 (0 0 1): Comparison of a pure surface with a surface containing an Al defect SO CHEMICAL PHYSICS LETTERS LA English DT Article ID AB-INITIO; ELECTRIC-FIELD; QUARTZ; CLUSTERS; AG; NANOPARTICLES; FILMS; SIO2 AB By employing DFT approaches we studied the adsorption of a single Ag atom and its cation on different sites of a pure alpha-quartz (001) surface and on an alpha-quartz (001) surface containing an Al defect. The energetically different adsorption sites of Ag and Ag+ were revealed and the profiles of diffusion were calculated. Diffusion of an Ag atom through the pure alpha-quartz surface is predicted to have a much lower barrier than an Ag cation. However in case of diffusion through the alpha-quartz surface with an Al defect the barriers are almost the same for both cation and neutral Ag. (C) 2013 Elsevier B. V. All rights reserved. C1 [Vakula, Nikita I.; Kuramshina, Gulnara M.] Moscow MV Lomonosov State Univ, Dept Phys Chem, Fac Chem, Moscow 119991, Russia. [Gorb, Leonid G.] Badger Tech Serv, Vicksburg, MS USA. [Hill, Frances] USA, Erdc, Vicksburg, MS USA. [Leszczynski, Jerzy] Jackson State Univ, ICNANOTOX, Dept Chem, Jackson, MS 39217 USA. RP Vakula, NI (reprint author), Moscow MV Lomonosov State Univ, Dept Phys Chem, Fac Chem, Moscow 119991, Russia. EM vakula.chem@gmail.com RI Kuramshina, Gulnara/G-8974-2011 OI Kuramshina, Gulnara/0000-0002-4044-471X FU RFBR [11-03-00040a]; National Science Foundation [NSF/CREST HRD-0833178, NSF DMR-1205194]; Mississippi Center for Supercomputing Research (MCSR) FX This work was partly supported by the RFBR grant No 11-03-00040a and by the National Science Foundation grant (NSF/CREST HRD-0833178 and NSF DMR-1205194).; We are grateful to the Research Computing Center of Lomonosov Moscow State University for the computational facilities and the use of the SKIF MSU 'Chebyshev' Supercomputer and to the Mississippi Center for Supercomputing Research (MCSR) for generous computational grant. NR 40 TC 5 Z9 5 U1 5 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD APR 19 PY 2013 VL 567 BP 27 EP 33 DI 10.1016/j.cplett.2013.02.067 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 122WQ UT WOS:000317349600006 ER PT J AU Andres, D Keyser, BM Petrali, J Benton, B Hubbard, KS McNutt, PM Ray, R AF Andres, Devon Keyser, Brian M. Petrali, John Benton, Betty Hubbard, Kyle S. McNutt, Patrick M. Ray, Radharaman TI Morphological and functional differentiation in BE (2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid SO BMC NEUROSCIENCE LA English DT Article DE Neurons; M17; Neurotoxicity; Cell maturation; Differentiation; Retinoic acid; Neuroexocytosis; Voltage-gated calcium channels ID IN-VITRO; HIPPOCAMPAL-NEURONS; PULMONARY TOXICITY; CALCIUM-CHANNELS; NEUROTOXICITY; MODELS; LINES; MIXTURES; EXPOSURE; CULTURE AB Background: Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell lines attractive as in vitro cell models to study neuronal functions and neurotoxicity. The clonal human neuroblastoma BE(2)-M17 cell line is known to differentiate into a more prominent neuronal cell type by treatment with trans-retinoic acid. However, there is a lack of information on the morphological and functional aspects of these differentiated cells. Results: We studied the effects of trans-retinoic acid treatment on (a) some differentiation marker proteins, (b) types of voltage-gated calcium (Ca2+) channels and (c) Ca2+-dependent neurotransmitter ([H-3] glycine) release in cultured BE(2)-M17 cells. Cells treated with 10 mu M trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha 7 (nAChR-alpha 7) and other neuronal markers. Moreover, retinoic acid treated cells had a significant increase in evoked Ca2+-dependent neurotransmitter release capacity. In toxicity studies of the toxic gas, phosgene (CG), that differentiation of M17 cells with RA was required to see the changes in intracellular free Ca2+ concentrations following exposure to CG. Conclusion: Taken together, retinoic acid treated cells had improved morphological features as well as neuronal characteristics and functions; thus, these retinoic acid differentiated BE(2)-M17 cells may serve as a better neuronal model to study neurobiology and/or neurotoxicity. C1 [Andres, Devon; Keyser, Brian M.; Petrali, John; Benton, Betty; Hubbard, Kyle S.; McNutt, Patrick M.; Ray, Radharaman] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Ray, R (reprint author), USA, Div Res, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM radharaman.ray@us.army.mil OI Andres, Devon/0000-0002-6823-4132; McNutt, Patrick/0000-0002-5703-4565 FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [Y1-A1-6179-04]; NIH/NIAID [Y1-A1-6179-04]; USAMRICD [A120-B. P2009-03]; U.S. Army Medical Research Institute of Chemical Defense FX This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division, an interagency agreement between NIH/NIAID (Y1-A1-6179-04) and the USAMRICD (A120-B. P2009-03) and in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command (USAMRMC). We acknowledge Dr. Heidi Hoard-Fruchey for giving us the antibodies for our studies on the cholinergic properties and Dr. Dorian Olivera for helping us with phosgene exposure of cells. We also acknowledge Drs. Shane Kasten and Brian Molles for their careful reviews of the manuscript and comments. NR 40 TC 10 Z9 11 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2202 J9 BMC NEUROSCI JI BMC Neurosci. PD APR 18 PY 2013 VL 14 AR 49 DI 10.1186/1471-2202-14-49 PG 12 WC Neurosciences SC Neurosciences & Neurology GA 139WS UT WOS:000318616300002 PM 23597229 ER PT J AU Borodin, O Zhuang, GRV Ross, PN Xu, K AF Borodin, Oleg Zhuang, Guorong V. Ross, Philip N. Xu, Kang TI Molecular Dynamics Simulations and Experimental Study of Lithium Ion Transport in Dilithium Ethylene Dicarbonate SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SOLID-ELECTROLYTE INTERPHASE; SOLVATION SHEATH STRUCTURE; AB-INITIO CALCULATIONS; DOT-O INTERACTIONS; LI-ION; NONAQUEOUS ELECTROLYTES; GRAPHITE/ELECTROLYTE INTERFACE; BATTERY ELECTROLYTES; PROPYLENE CARBONATE; ALKYL DICARBONATES AB Understanding the properties of the solid electrolyte interphase (SET) of lithium batteries is important for minimizing interfacial resistance and improving battery safety and cycling. Ion transport has been investigated in the dilithium ethylene dicarbonate (Li2EDC) component of the SEI by impedance spectroscopy and molecular dynamics (MD) simulations employing a revised many-body polarizable APPLE&P force field. The developed force field accurately described the binding energies in LiCH3CO3, its dimer, and Li2EDC calculated at the G4MP2 and MP2 levels. M05-2X and LC-omega PBE functionals predicted too high binding energy in lithium alkyl carbonates compared to the G4MP2 results, while the MP2 and M06-L predictions agreed well with the G4MP2 data. The conductivity of Li2EDC at room temperature was found to be 10(-9) S/cm from impedance measurements and extrapolation of MD simulation results. A near Arrhenius temperature dependence of Li2EDC's conductivity was found in the MD simulations with an activation energy ranging from 64 to 84 kJ/mol. At room temperature, the lithium transport was subdiffusive on time scales shorter than similar to 10(-2) s in MD simulations corresponding to the onset of the plateau of resistivity vs frequency occurring at frequencies lower than 10(2) Hz. The influence of Li2EDC ordering on the ion transport was investigated by contrasting supercooled amorphous melts and ordered material. At 393 K Li+ transport was heterogeneous, showing chainlike and looplike Li+ correlated displacements. The non-Gaussianity of Li+ transport was examined. The influence of polarization on the structure of the lithium coordination shell and ion transport has been investigated in the molten phase of Li2EDC and contrasted with the previous results obtained for room-temperature ionic liquids (RTILs). Nonpolarizable Li2EDC exhibited orders of magnitude slower dynamics below 600 K and a higher activation energy for the Li+ diffusion coefficient. Initial simulations of Li2EDC dissolved in an EC:DMC(3:7)/LiPF6 liquid electrolyte were performed at 450 K and showed a strong aggregation of Li2EDC consistent with its phase separation from the electrolyte. The plasticizing effects of carbonate electrolyte on Li2EDC dynamics were examined. C1 [Borodin, Oleg; Xu, Kang] USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zhuang, Guorong V.; Ross, Philip N.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. RP Borodin, O (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. Department of Energy [DE-IA01-11EE003413]; U.S. Army Research Laboratory (ARL) [DE-IA01-11EE003413] FX This work was supported via an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory (ARL) under DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs within Batteries for Advanced Transportation Technologies (BATT) and ABR Program. Computational resources from DoD's High Performance Computing Modernization Program's (HPCMP) program are acknowledged. Insightful discussions with T. Richard Jow (ARL) are highly appreciated. NR 60 TC 30 Z9 30 U1 5 U2 167 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 18 PY 2013 VL 117 IS 15 BP 7433 EP 7444 DI 10.1021/jp4000494 PG 12 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 130WH UT WOS:000317950300004 ER PT J AU Onmus-Leone, F Hang, J Clifford, RJ Yang, Y Riley, MC Kuschner, RA Waterman, PE Lesho, EP AF Onmus-Leone, Fatma Hang, Jun Clifford, Robert J. Yang, Yu Riley, Matthew C. Kuschner, Robert A. Waterman, Paige E. Lesho, Emil P. TI Enhanced De Novo Assembly of High Throughput Pyrosequencing Data Using Whole Genome Mapping SO PLOS ONE LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; PROVIDENCIA-STUARTII; CLINICAL ISOLATE; SEQUENCE; STRAIN; DIVERSITY; OUTBREAK; AFGHANISTAN; VALIDATION; BLA(NDM-1) AB Despite major advances in next-generation sequencing, assembly of sequencing data, especially data from novel microorganisms or re-emerging pathogens, remains constrained by the lack of suitable reference sequences. De novo assembly is the best approach to achieve an accurate finished sequence, but multiple sequencing platforms or paired-end libraries are often required to achieve full genome coverage. In this study, we demonstrated a method to assemble complete bacterial genome sequences by integrating shotgun Roche 454 pyrosequencing with optical whole genome mapping (WGM). The whole genome restriction map (WGRM) was used as the reference to scaffold de novo assembled sequence contigs through a stepwise process. Large de novo contigs were placed in the correct order and orientation through alignment to the WGRM. De novo contigs that were not aligned to WGRM were merged into scaffolds using contig branching structure information. These extended scaffolds were then aligned to the WGRM to identify the overlaps to be eliminated and the gaps and mismatches to be resolved with unused contigs. The process was repeated until a sequence with full coverage and alignment with the whole genome map was achieved. Using this method we were able to achieved 100% WGRM coverage without a paired-end library. We assembled complete sequences for three distinct genetic components of a clinical isolate of Providencia stuartii: a bacterial chromosome, a novel bla(NDM-1) plasmid, and a novel bacteriophage, without separately purifying them to homogeneity. C1 [Onmus-Leone, Fatma; Clifford, Robert J.; Riley, Matthew C.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA. [Hang, Jun; Yang, Yu; Kuschner, Robert A.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Onmus-Leone, F (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA. EM Fatma.Onmus-Leone.ctr@us.army.mil; Jun.Hang.ctr@us.army.mil RI Valle, Ruben/A-7512-2013 FU United States Army Medical Command [09-050, 11-035]; Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [C0709_12_WR, I0361_12_WR] FX This study was supported by the United States Army Medical Command Policies 09-050 and 11-035, and was partially funded by grants C0709_12_WR and I0361_12_WR from the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 13 Z9 13 U1 0 U2 20 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 17 PY 2013 VL 8 IS 4 AR e61762 DI 10.1371/journal.pone.0061762 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 130IK UT WOS:000317907200083 PM 23613926 ER PT J AU White, MT Bejon, P Olotu, A Griffin, JT Riley, EM Kester, KE Ockenhouse, CF Ghani, AC AF White, Michael T. Bejon, Philip Olotu, Ally Griffin, Jamie T. Riley, Eleanor M. Kester, Kent E. Ockenhouse, Christian F. Ghani, Azra C. TI The Relationship between RTS,S Vaccine-Induced Antibodies, CD4(+) T Cell Responses and Protection against Plasmodium falciparum Infection SO PLOS ONE LA English DT Article ID MALARIA-NAIVE ADULTS; PHASE 2A TRIAL; POLYMERASE-CHAIN-REACTION; INSTITUTE-OF-RESEARCH; CIRCUMSPOROZOITE PROTEIN; ANOPHELINE MOSQUITOS; DOUBLE-BLIND; EFFICACY; SPOROZOITES; CHILDREN AB Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data from malaria-naive adults vaccinated with RTS, S and subjected to experimental P. falciparum challenge, we characterised the relationship between antibodies, CD4(+) T cell responses and protection from infection. Both anti-CSP antibody titres and CSP-specific CD4(+) T cells were identified as immunological surrogates of protection, with RTS,S induced anti-CSP antibodies estimated to prevent 32% (95% confidence interval (CI) 24%-41%) of infections. The addition of RTS,S induced CSP-specific CD4(+) T cells was estimated to increase vaccine efficacy against infection to 40% (95% CI, 34%-48%). This protective efficacy is estimated to result from a 96.1% (95% CI, 93.4%-97.8%) reduction in the liver-to-blood parasite inoculum, indicating that in volunteers who developed P. falciparum infection, a small number of parasites (often the progeny of a single surviving sporozoite) are responsible for breakthrough blood-stage infections. C1 [White, Michael T.; Griffin, Jamie T.; Ghani, Azra C.] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modelling, London, England. [Bejon, Philip; Olotu, Ally] Kenya Govt Med Res Ctr, Kilifi, Kenya. [Bejon, Philip] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England. [Riley, Eleanor M.] Univ London London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1E 7HT, England. [Kester, Kent E.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP White, MT (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modelling, London, England. EM m.white08@imperial.ac.uk RI Ghani, Azra/B-8560-2009; Riley, Eleanor/C-8960-2013 OI Riley, Eleanor/0000-0003-3447-3570 FU MRC Centre; MRC [G1002624]; Wellcome Trust; MVI/PATH; EviMalaR network; Bill and Melinda Gates Foundation Vaccine Modelling Initiative FX MTW was supported by an MRC Centre studentship. PB is funded by an MRC Fellowship G1002624). AO is funded by a Wellcome Trust Strategic Award. JTG is funded by an MRC Fellowship. EMR acknowledges funding from MVI/PATH, the MRC and the EviMalaR network (EU FP7). ACG acknowledges support from the Bill and Melinda Gates Foundation Vaccine Modelling Initiative and MRC Centre funding. The analysis was conducted following a call for proposals initiated and facilitated by GSK Biologicals. Employees of GSK Biologicals reviewed and commented on early draft manuscripts, but were not involved in the final approval of the manuscript. GSK Biologicals did not fund the investigators to undertake the analysis. GSK funded transport expenses for the investigators to attend a meeting to discuss their progress. GSK had no role in study design, data collection or the final decision to publish. NR 43 TC 43 Z9 43 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 16 PY 2013 VL 8 IS 4 AR e61395 DI 10.1371/journal.pone.0061395 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 130DR UT WOS:000317893400061 PM 23613845 ER PT J AU Trappey, AF Berry, JS Vreeland, TJ Hale, DF Sears, AK Clifton, G Ponniah, S Papamichail, M Perez, SA Mittendorf, E Peoples, GE AF Trappey, Alfred F. Berry, John S. Vreeland, Timothy J. Hale, Diane F. Sears, Alan K. Clifton, Guy Ponniah, Sathibalan Papamichail, Michael Perez, Sonia A. Mittendorf, Elizabeth Peoples, George E. TI Delayed urticarial reactions in the phase II trial of HER2/neu peptide vaccines plus GM-CSF vs. GM-CSF alone in high risk breast cancer patients SO CANCER RESEARCH LA English DT Meeting Abstract CT 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 06-10, 2013 CL Washington, DC SP Amer Assoc Canc Res C1 [Trappey, Alfred F.; Berry, John S.; Vreeland, Timothy J.; Hale, Diane F.; Sears, Alan K.; Clifton, Guy; Peoples, George E.] Brooke Army Med Ctr, San Antonio, TX USA. [Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Papamichail, Michael] Canc Immunol & Immunotherapy Ctr, San Antonio, TX USA. [Perez, Sonia A.] Canc Immunol & Immunotherapy Ctr, Athens, Greece. [Mittendorf, Elizabeth] Univ Texas MD Anderson Canc Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2013 VL 73 IS 8 SU 1 MA 4670 DI 10.1158/1538-7445.AM2013-4670 PG 1 WC Oncology SC Oncology GA AA6PP UT WOS:000331220604255 ER PT J AU Reynolds, JG Reynolds, CL Mohanta, A Muth, JF Rowe, JE Everitt, HO Aspnes, DE AF Reynolds, J. G. Reynolds, C. L., Jr. Mohanta, A. Muth, J. F. Rowe, J. E. Everitt, H. O. Aspnes, D. E. TI Shallow acceptor complexes in p-type ZnO SO APPLIED PHYSICS LETTERS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; MULTIPLE-QUANTUM WELLS; THIN-FILMS; OPTICAL-PROPERTIES; PHOTOLUMINESCENCE; EXCITON; ENERGY AB We show that N-doped ZnO films grown on sapphire can exhibit significant (similar to 10(18) cm(-3)) room-temperature p-type behavior when sufficient nitrogen (N) is incorporated and the material is annealed appropriately. Substitutional N on the oxygen (O) sublattice is a deep acceptor; however, shallow acceptor complexes involve N, H, and zinc vacancies (V-Zn). Combining secondary ion mass spectrometry, Raman-scattering, photoluminescence, and Hall-effect data, we establish the evolution of N from its initial incorporation on a Zn site to a final shallow acceptor complex V-Zn-N-O-H+ with an ionization energy of ca. 130 meV. This complex is responsible for the observed p-type behavior. (C) 2013 AIP Publishing LLC [http://dx.doi.org/10.1063/1.4802753] C1 [Reynolds, J. G.; Rowe, J. E.; Aspnes, D. E.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Reynolds, C. L., Jr.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mohanta, A.] USA, AMRDEC, Res Participat Program, Oak Ridge Inst Sci & Educ, Redstone Arsenal, AL 35898 USA. [Muth, J. F.] N Carolina State Univ, Dept Elect & Comp Engn, Monteith Res Ctr, Raleigh, NC 27695 USA. [Everitt, H. O.] USA, Aviat & Missile RD&E Ctr, CM Bowden Lab, Redstone Arsenal, AL 35898 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27705 USA. RP Reynolds, JG (reprint author), N Carolina State Univ, Dept Phys, 1009 Capability Dr, Raleigh, NC 27695 USA. RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012 OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721 FU U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC); Extreme Light Sources DARPA project [W31P4Q-08-1-0003] FX The authors are pleased to acknowledge Professor Y.-T. Zhu for the use of his Raman system, Dr. F. Stevie for providing the SIMS depth profiles, and J. V. Foreman and J. Simmons for their assistance with the PL measurements. Research was supported in part by an appointment (A. Mohanta) to the Postgraduate Research Participation Program at the U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and AMRDEC. We gratefully acknowledge the support from the Extreme Light Sources DARPA project W31P4Q-08-1-0003 administered by the University of Florida. NR 27 TC 40 Z9 45 U1 4 U2 135 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 15 PY 2013 VL 102 IS 15 AR 152114 DI 10.1063/1.4802753 PG 5 WC Physics, Applied SC Physics GA 135EC UT WOS:000318269200045 ER PT J AU Otaki, Y Gransar, H Berman, DS Cheng, VY Dey, D Lin, FY Achenbach, S Al-Mallah, M Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Chinnaiyan, K Chow, BJW Delago, A Hadamitzky, M Hausleiter, J Kaufmann, P Maffei, E Raff, G Shaw, LJ Villines, TC Dunning, A Min, JK AF Otaki, Yuka Gransar, Heidi Berman, Daniel S. Cheng, Victor Y. Dey, Damini Lin, Fay Y. Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin J. W. Delago, Augustin Hadamitzky, Martin Hausleiter, Joerg Kaufmann, Philipp Maffei, Erica Raff, Gilbert Shaw, Leslee J. Villines, Todd C. Dunning, Allison Min, James K. TI Impact of Family History of Coronary Artery Disease in Young Individuals (from the CONFIRM Registry) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID MULTIDETECTOR COMPUTED-TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; MIDDLE-AGED ADULTS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ANGIOGRAPHY; PLAQUE; WOMEN; MEN AB Although family history (FH) of coronary artery disease (CAD) is considered a risk factor for future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with FH of CAD have been inadequately studied. From 27,125 consecutive patients who underwent coronary computed tomographic angiography, 6,308 young patients (men aged <55 years and women aged <65 years) without known CAD were identified. Obstructive CAD was defined as >50% stenosis in a coronary artery >2 mm diameter. Riskadjusted logistic regression, Kaplan-Meier, and Cox proportional-hazards models were used to compare patients with and without FH of CAD. Compared with subjects without FH of CAD, those with FH of CAD (FH +) had higher prevalences of any CAD (40% vs 30%, p <0.001) and obstructive CAD (11% vs 7%, p <0.001), with multivariate odds of FH + increasing the likelihood of obstructive CAD by 71% (p <0.001). After a mean followup period of 2 1 years (42 myocardial infarctions and 39 all-cause deaths), FH + patients experienced higher annual rates of myocardial infarction (0.5% vs 0.2%, log-rank p = 0.001), with a positive FH the strongest predictor of myocardial infarction (hazard ratio 2.6, 95% confidence interval 1.4 to 4.8, p = 0.002). In conclusion, young FH + patients have higher presence, extent, and severity of CAD, which are associated with increased risk for myocardial infarction. Compared with other clinical CAD risk factors, positive FH in young patients is the strongest clinical predictor of future unheralded myocardial infarction. 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:1081-1086) C1 [Otaki, Yuka; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Cedars Sinai Heart Inst, Dept Imaging, Los Angeles, CA USA. [Otaki, Yuka; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Cedars Sinai Heart Inst, Dept Med, Los Angeles, CA USA. [Dey, Damini] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA. [Dey, Damini] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA. [Berman, Daniel S.; Cheng, Victor Y.; Dey, Damini; Min, James K.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Lin, Fay Y.] Weill Cornell Med Coll, Dept Med, New York, NY USA. [Dunning, Allison] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA. New York Presbyterian Hosp, New York, NY USA. [Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, D-91054 Erlangen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA. [Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA. [Cademartiri, Filippo; Maffei, Erica] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Monastier, Italy. [Cademartiri, Filippo; Maffei, Erica] Erasmus MC, Dept Radiol, Rotterdam, Netherlands. [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA. [Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea. [Chinnaiyan, Kavitha; Raff, Gilbert] William Beaumont Hosp, Royal Oak, MI 48072 USA. [Chow, Benjamin J. W.] Univ Ottawa, Dept Med & Radiol, Ottawa, ON, Canada. [Delago, Augustin] Capitol Cardiol Associates, Albany, NY USA. [Hadamitzky, Martin; Hausleiter, Joerg] Deutsch Herzzentrum Munich, Div Cardiol, Munich, Germany. [Kaufmann, Philipp] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Min, JK (reprint author), Cedars Sinai Heart Inst, Dept Imaging, Los Angeles, CA USA. EM james.min@cshs.org RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016; OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei, Erica/0000-0002-0388-4433; Villines, Todd/0000-0003-2674-3702; Al-Mallah, Mouaz/0000-0003-2348-0484 NR 26 TC 11 Z9 12 U1 0 U2 6 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD APR 15 PY 2013 VL 111 IS 8 BP 1081 EP 1086 DI 10.1016/j.amjcard.2012.12.042 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 130CK UT WOS:000317890100001 PM 23411105 ER PT J AU Goertz, CM Long, CR Hondras, MA Petri, R Delgado, R Lawrence, DJ Owens, EF Meeker, WC AF Goertz, Christine M. Long, Cynthia R. Hondras, Maria A. Petri, Richard Delgado, Roxana Lawrence, Dana J. Owens, Edward F., Jr. Meeker, William C. TI Adding Chiropractic Manipulative Therapy to Standard Medical Care for Patients With Acute Low Back Pain Results of a Pragmatic Randomized Comparative Effectiveness Study SO SPINE LA English DT Article DE low back pain; chiropractic manipulation; military medicine; physical functioning ID SPINAL MANIPULATION; MANAGEMENT; OUTCOMES AB Study Design. Randomized controlled trial. Objective. To assess changes in pain levels and physical functioning in response to standard medical care (SMC) versus SMC plus chiropractic manipulative therapy (CMT) for the treatment of low back pain (LBP) among 18 to 35-year-old active-duty military personnel. Summary of Background Data. LBP is common, costly, and a significant cause of long-term sick leave and work loss. Many different interventions are available, but there exists no consensus on the best approach. One intervention often used is manipulative therapy. Current evidence from randomized controlled trials demonstrates that manipulative therapy may be as effective as other conservative treatments of LBP, but its appropriate role in the healthcare delivery system has not been established. Methods. Prospective, 2-arm randomized controlled trial pilot study comparing SMC plus CMT with only SMC. The primary outcome measures were changes in back-related pain on the numerical rating scale and physical functioning at 4 weeks on the Roland-Morris Disability Questionnaire and back pain functional scale (BPFS). Results. Mean Roland-Morris Disability Questionnaire scores decreased in both groups during the course of the study, but adjusted mean scores were significantly better in the SMC plus CMT group than in the SMC group at both week 2 (P < 0.001) and week 4 (P = 0.004). Mean numerical rating scale pain scores were also significantly better in the group that received CMT. Adjusted mean back pain functional scale scores were significantly higher (improved) in the SMC plus CMT group than in the SMC group at both week 2 (P < 0.001) and week 4 (P = 0.004). Conclusion. The results of this trial suggest that CMT in conjunction with SMC offers a significant advantage for decreasing pain and improving physical functioning when compared with only standard care, for men and women between 18 and 35 years of age with acute LBP. C1 [Goertz, Christine M.; Long, Cynthia R.; Hondras, Maria A.] Palmer Ctr Chiropract Res, Davenport, IA 52803 USA. [Petri, Richard] Phys Med & Integrat Care Serv, Ft Bliss, TX USA. [Delgado, Roxana] Samueli Inst, Alexandria, VA USA. [Lawrence, Dana J.] Palmer Coll Chiropract, Davenport, IA USA. [Owens, Edward F., Jr.] TriMax Direct, St Paul, MN USA. [Meeker, William C.] Palmer Coll Chiropract, San Jose, CA USA. RP Goertz, CM (reprint author), Palmer Ctr Chiropract Res, 741 Brady St, Davenport, IA 52803 USA. EM christine.goertz@palmer.edu OI Goertz, Christine/0000-0002-4700-3669 FU Samueli Institute; National Center for Research Resources, National Institutes of Health [C06 RR15433] FX Samueli Institute grant funds were received to support this work. Some of this work was conducted in a facility constructed with support from Research Facilities Improvement Grant (C06 RR15433) from the National Center for Research Resources, National Institutes of Health. NR 23 TC 16 Z9 16 U1 1 U2 24 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD APR 15 PY 2013 VL 38 IS 8 BP 627 EP 634 DI 10.1097/BRS.0b013e31827733e7 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 125TY UT WOS:000317565400010 PM 23060056 ER PT J AU Wei, M Boutwell, RC Garrett, GA Goodman, K Rotella, P Schoenfeld, WV AF Wei, M. Boutwell, R. C. Garrett, G. A. Goodman, K. Rotella, P. Schoenfeld, W. V. TI Optimization of photoluminescence lifetime for ZnO films grown on ZnO substrates at low temperature SO MATERIALS LETTERS LA English DT Article DE ZnO; Epitaxial growth; Homoepitaxy; Photoluminescence lifetime; Structural; Defects ID SINGLE-CRYSTAL; POLAR AB ZnO films were grown on Zn-polar ZnO substrates with 0.5 degrees miscut toward the [1EQ \O(1,-)00] direction by plasma-assisted molecular beam epitaxy (PAMBE). An atomically flat surface with one or two monolayer step height along the [0001] direction was achieved at low. growth temperature. Wet etching of the substrates and ozone exposure reduced defects and improved photoluminescence (PL) lifetime by a factor of two. A 20 min interval between oxygen plasma ignition and growth was found necessary for excellent crystallinity and yielded high PL lifetimes of 0.179 ns. By decreasing the growth temperature in the low temperature range, the growth rate was increased from 0.02 mu m/h to 0.246 mu m/h, and correspondingly PL lifetime was improved by an order of magnitude, from 0.018 ns to 0.3 ns. (c) 2013 Elsevier B.V. All rights reserved. C1 [Wei, M.; Boutwell, R. C.; Schoenfeld, W. V.] Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA. [Garrett, G. A.; Goodman, K.; Rotella, P.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Schoenfeld, WV (reprint author), Univ Cent Florida, CREOL, Coll Opt & Photon, 4000 Cent Florida Blvd, Orlando, FL 32816 USA. EM winston@creol.ucf.edu OI Boutwell, Ryan/0000-0003-2321-1495 FU Army Research Laboratory under Cooperative Agreement [W911NF-11-2-0025] FX The authors would like to acknowledge financial support of this work by the Army Research Laboratory under Cooperative Agreement number W911NF-11-2-0025. NR 14 TC 1 Z9 1 U1 0 U2 47 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD APR 15 PY 2013 VL 97 BP 11 EP 14 DI 10.1016/j.matlet.2013.01.090 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 120IS UT WOS:000317164600004 ER PT J AU Florio, LA AF Florio, L. A. TI Direct particle motion and interaction modeling method applied to simulate propellant burn SO APPLIED MATHEMATICAL MODELLING LA English DT Article DE Computational; Fluid; Particle; Propellant burn ID GRANULATED PROPELLANTS; NUMERICAL-SIMULATION; TURBULENT FLOWS; TRANSIENT FLOW; COMBUSTION; SYSTEM; FIELD AB A direct particle motion and particle interaction modeling method was developed to provide an alternative means of capturing the fundamental phenomena occurring during the burning of propellant grains. Individual propellant grains and other moving components are directly incorporated into the computational domain, removing the need for correlations for particle drag and interaction effects. The motion of the individual particles is calculated from the locally acting fluid induced and collision effect forces and moments. Particle/object interactions are handled through a soft particle collision algorithm. Localized mass and energy sources, accompanied by a shrinking particle size, simulate the effects of the combustion process. The method is applied to the burning of propellant in a two-dimensional planar gun type system. Parametric studies were performed varying the parameters related to the propellant and projectile to explore the capabilities of the current modeling method and to determine the sensitivity of the gas, propellant, and projectile conditions. The model captured the local pressure waves moving between the breech and the bullet base not observed using a bulk effect model. The results also indicated that the conditions in the system that are most sensitive to the burn rate exponent where a 24% increase in the exponent produced a 200% increase in the peak pressure at the breech. The study demonstrated the utility of this new model in exploring in particular the localized phenomena and conditions that develop during the burning of propellant. Published by Elsevier Inc. C1 USA, ARDEC, Technol Branch, Small Caliber Armaments Div,RDAR WSW F, Picatinny Arsenal, NJ 07806 USA. RP Florio, LA (reprint author), USA, ARDEC, Technol Branch, Small Caliber Armaments Div,RDAR WSW F, Bldg 8, Picatinny Arsenal, NJ 07806 USA. EM laurie.a.florio.civ@mail.mil FU Joint Service Small Arms Program (JSSAP) Office FX This work was funded by the Joint Service Small Arms Program (JSSAP) Office. NR 48 TC 6 Z9 6 U1 1 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0307-904X J9 APPL MATH MODEL JI Appl. Math. Model. PD APR 15 PY 2013 VL 37 IS 8 BP 5606 EP 5626 DI 10.1016/j.apm.2012.10.030 PG 21 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA 114VA UT WOS:000316769600003 ER PT J AU Yeager, JD Ramos, KJ Pesce-Rodriguez, RA Piraino, SM AF Yeager, J. D. Ramos, K. J. Pesce-Rodriguez, R. A. Piraino, S. M. TI Microstructural effects of processing in the plastic-bonded explosive Composition A-3 SO MATERIALS CHEMISTRY AND PHYSICS LA English DT Article DE Composite materials; Interfaces; Neutron reflectivity; Secondary ion mass spectroscopy (SMS); Microstructure ID NEUTRON REFLECTOMETRY; ENERGETIC MATERIALS; INTERFACE; NANOINDENTATION; DEFORMATION; MORPHOLOGY; PARTICLES; PBX-9501; POLYMERS; CRYSTAL AB Multiscale model development for composites such as plastic-bonded explosives (PBXs) is critical for assessing structural integrity and behavior and for developing new materials. For models to be successful they must reproduce bulk material responses while incorporating important microstructural features. These features arise at the mesoscale during processing, and while they have commensurate effects on composite material response they are not easily identified or characterized. Here, we study Composition A-3 as a representative PBX, chosen both for relevance to the field and as a tractable formulation to model. Composition A-3 is formulated by mixing micron-scale explosive crystals with an emulsified polyethylene solution, then breaking the emulsion to form small crystal/polyethylene agglomerates suitable for pressing and machining. Key aspects of this formulation process that may potentially affect the microstructure were identified. Specifically, the emulsification chemicals in a model system were found to partially dissolve or degrade the explosive and create a diffuse interface between the crystal and binder. The diffuse interfaces, along with some of the chemicals that remain in the composite after manufacture, create a heterogeneous multicomponent system that likely influences adhesion, void formation, and crack formation. The observed interfaces may be difficult to model. These results are compared with previous interfacial studies in other PBX materials, and the necessity of including such data in mesoscale models is discussed. (C) 2013 Elsevier B.V. All rights reserved. C1 [Yeager, J. D.; Ramos, K. J.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Pesce-Rodriguez, R. A.; Piraino, S. M.] USA, Res Lab, ATTN RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Yeager, JD (reprint author), Los Alamos Natl Lab, POB 1663,MS P952, Los Alamos, NM 87545 USA. EM jyeager@lanl.gov; kramos@lanl.gov; rose.a.pesce-rodriguez.civ@mail.mil; stephanie.m.piraino-haynes.civ@mail.mil OI Yeager, John/0000-0002-3121-6053 FU National Nuclear Security Administration Science Campaign 2; Agnew National Security Fellowship; Lethality Division of the Weapons and Materials Research Directorate; National Nuclear Security Administration of the U.S. Department of Energy [DE-AC52-06NA25396] FX Los Alamos National Laboratory is operated by LANS LLC for the Department of Energy. Funding for work at Los Alamos was provided by the National Nuclear Security Administration Science Campaign 2, and JDY is supported by an Agnew National Security Fellowship. Funding for work at the Army Research Laboratory was provided by the Lethality Division of the Weapons and Materials Research Directorate. This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility. Los Alamos National Laboratory, an affirmative action equal opportunity employer, is operated by Los Alamos National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract DE-AC52-06NA25396. We thank J. Majewski and S. Singh (LANL) for assistance with the neutron reflectometry measurements, and D. Hooks (LANL) for helpful discussion and technical editing. NR 43 TC 2 Z9 3 U1 2 U2 36 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0254-0584 J9 MATER CHEM PHYS JI Mater. Chem. Phys. PD APR 15 PY 2013 VL 139 IS 1 BP 305 EP 313 DI 10.1016/j.matchemphys.2013.01.041 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA 111KJ UT WOS:000316519900043 ER PT J AU Montain, SJ McGraw, SM Ely, MR Grier, TL Knapik, JJ AF Montain, Scott J. McGraw, Susan M. Ely, Matthew R. Grier, Tyson L. Knapik, Joseph J. TI A retrospective cohort study on the influence of UV index and race/ethnicity on risk of stress and lower limb fractures SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Bone health; Vitamin D; Risk factors; Military ID SERUM 25-HYDROXYVITAMIN D; VITAMIN-D INSUFFICIENCY; HIP FRACTURE; UNITED-STATES; HIGH PREVALENCE; PREGNANT-WOMEN; D DEFICIENCY; LIFE-STYLE; POPULATION; RECRUITS AB Background: Low vitamin D status increases the risk of stress fractures. As ultraviolet (UV) light is required for vitamin D synthesis, low UV light availability is thought to increase the risk of vitamin D insufficiency and poor bone health. The purpose of this investigation was to determine if individuals with low UV intensity at their home of record (HOR) or those with darker complexions are at increased risk of developing stress fractures and lower limb fractures during U.S. Army Basic Combat Training (BCT). Methods: This was a retrospective cohort study using the Armed Forces Health Surveillance Center data repository. All Basic trainees were identified from January 1997 to January 2007. Cases were recruits diagnosed with stress fractures and lower limb fractures during BCT. The recruit's home of record (HOR) was identified from the Defense Manpower Data Center database. The average annual UV intensity at the recruits' HOR was determined using a U.S National Weather Service database and recruits were stratified into low (<= 3.9); moderate (4.0-5.4), and high (>= 5.5) UV index regions. Race was determined from self-reports. Results: The dataset had 421,461 men and 90,141women. Compared to men, women had greater risk of developing stress fractures (odds ratio (OR) = 4.5, 95% confidence interval (95%CI) = 4.4-4.7, p < 0.01). Contrary to the hypothesized effect, male and female recruits from low UV index areas had a slightly lower risk of stress fractures (male OR (low UV/high UV) = 0.92, 95%CI = 0.87-0.97; females OR = 0.89, 95%CI = 0.84-0.95, p < 0.01) and were at similar risk for lower limb fractures (male OR = 0.98, 95%CI = 0.89-1.07; female OR = 0.93, 95%CI = 0.80-1.09) than recruits from high UV index areas. Blacks had lower risk of stress and lower limb fractures than non-blacks, and there was no indication that Blacks from low UV areas were at increased risk for bone injuries. Conclusions: The UV index at home of record is not associated with stress or lower limb fractures in BCT. These data suggest that UV intensity is not a risk factor for poor bone health in younger American adults. C1 [Montain, Scott J.; McGraw, Susan M.; Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Grier, Tyson L.; Knapik, Joseph J.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. EM scott.montain@us.army.mil OI Ely, Matthew/0000-0002-0618-7078 NR 31 TC 3 Z9 3 U1 1 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD APR 12 PY 2013 VL 14 AR 135 DI 10.1186/1471-2474-14-135 PG 9 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 140AF UT WOS:000318625900001 PM 23587313 ER PT J AU Petr, M Katzman, BA DiNatale, W Hammond, PT AF Petr, Michael Katzman, Bat-ami DiNatale, William Hammond, Paula T. TI Synthesis of a New, Low-T-g Siloxane Thermoplastic Elastomer with a Functionalizable Backbone and Its Use as a Rapid, Room Temperature Photoactuator SO MACROMOLECULES LA English DT Article ID LIQUID-CRYSTALLINE POLYMERS; FREE-RADICAL POLYMERIZATION; TRIBLOCK COPOLYMER GELS; BLOCK-COPOLYMERS; DIBLOCK COPOLYMERS; MECHANICAL-PROPERTIES; PHASE-TRANSITIONS; X-RAY; AZOBENZENE; MORPHOLOGY AB A new, low-T-g siloxane thermoplastic elastomer with a functionalizable backbone was synthesized via sequential anionic polymerization and coupling, and its utility as a platform to produce functional elastomers was demonstrated by the attachment of a photoresponsive liquid crystal to produce a rapid, room temperature photoactuator. Polystyrene was used as a hard glassy end block, and poly(vinylmethylsiloxane) served as the soft middle segment in a polystyrene-b-poly(vinylmethylsiloxane)-b-polystyrene ABA triblock copolymer. The vinyl side chain was used to attach a side on oriented mesogen to the siloxane backbone, and the resulting liquid crystal triblock copolymer was characterized with reversible photocontraction tests, where it was shown to be both elastomeric and rapidly photoresponsive at room temperature. Rather than simply undergoing a bending mechanism, an oriented thin cast film of the elastomer was observed to contract reversibly at a tensile strain of 3.3% against 253 kPa of applied stress in similar to 5.9 s. This strategy to produce functional liquid crystal elastomers is based on the formation of spherical block copolymers with a low temperature T-g for the soft domain, in contrast to cross linked elastomers. Because the approach is simple, robust, and applicable to a wide variety of functional moieties, the resulting materials are thermoplastics that can be processed to achieve preferential orientation using standard methods, thus enhancing the capability to produce and utilize functional actuators. C1 [Petr, Michael; Katzman, Bat-ami; Hammond, Paula T.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [DiNatale, William] USA, Res Off, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. RP Hammond, PT (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM hammond@mit.edu OI Gordon, Bat-ami/0000-0002-1775-7849 FU U.S. Army Research Office [W911NF-07-D-0004] FX The authors of this paper thank the U.S. Army Research Office for financial support of this research under Contract W911NF-07-D-0004. NR 82 TC 16 Z9 16 U1 7 U2 137 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD APR 9 PY 2013 VL 46 IS 7 BP 2823 EP 2832 DI 10.1021/ma400031z PG 10 WC Polymer Science SC Polymer Science GA 124BH UT WOS:000317438300033 ER PT J AU Graham, BS Enama, ME Nason, MC Gordon, IJ Peel, SA Ledgerwood, JE Plummer, SA Mascola, JR Bailer, RT Roederer, M Koup, RA Nabel, GJ AF Graham, Barney S. Enama, Mary E. Nason, Martha C. Gordon, Ingelise J. Peel, Sheila A. Ledgerwood, Julie E. Plummer, Sarah A. Mascola, John R. Bailer, Robert T. Roederer, Mario Koup, Richard A. Nabel, Gary J. CA VRC 008 Study Team TI DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial SO PLOS ONE LA English DT Article ID HEPATITIS-A VACCINE; T-CELL RESPONSES; NEUTRALIZING ANTIBODY; CANDIDATE VACCINE; HEALTHY-ADULTS; IMMUNOGENICITY EVALUATION; PHASE-1 SAFETY; JET INJECTION; PLASMID DNA; HIV-1 AB Background: DNA vaccine immunogenicity has been limited by inefficient delivery. Needle-free delivery of DNA using a CO2-powered Biojector (R) device was compared to delivery by needle and syringe and evaluated for safety and immunogenicity. Methods: Forty adults, 18-50 years, were randomly assigned to intramuscular (IM) vaccinations with DNA vaccine, VRC-HIVDNA016-00-VP, (weeks 0, 4, 8) by Biojector (R) 2000 (TM) or needle and syringe (N/S) and boosted IM at week 24 with VRC-HIVADV014-00-VP (rAd5) with N/S at 10(10) or 10(11) particle units (PU). Equal numbers per assigned schedule had low (<= 500) or high (>500) reciprocal titers of preexisting Ad5 neutralizing antibody. Results: 120 DNA and 39 rAd5 injections were given; 36 subjects completed follow-up research sample collections. IFN-gamma ELISpot response rates were 17/19 (89%) for Biojector (R) and 13/17 (76%) for N/S delivery at Week 28 (4 weeks post rAd5 boost). The magnitude of ELISpot response was about 3-fold higher in Biojector (R) compared to N/S groups. Similar effects on response rates and magnitude were observed for CD8+, but not CD4+ T-cell responses by ICS. Env-specific antibody responses were about 10-fold higher in Biojector-primed subjects. Conclusions: DNA vaccination by Biojector (R) was well-tolerated and compared to needle injection, primed for greater IFN-gamma ELISpot, CD8+ T-cell, and antibody responses after rAd5 boosting. Trial Registration: ClinicalTrials.gov NCT00109629 C1 [Graham, Barney S.; Enama, Mary E.; Gordon, Ingelise J.; Ledgerwood, Julie E.; Plummer, Sarah A.; Mascola, John R.; Bailer, Robert T.; Roederer, Mario; Koup, Richard A.; Nabel, Gary J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA. [Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM bgraham@nih.gov FU National Institute of Allergy and Infectious Diseases (NIAID) FX Funding for the conduct of this clinical trial was provided by the National Institute of Allergy and Infectious Diseases (NIAID) intramural research program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 20 Z9 21 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 8 PY 2013 VL 8 IS 4 AR e59340 DI 10.1371/journal.pone.0059340 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 130FG UT WOS:000317898000011 PM 23577062 ER PT J AU Hindenlang, MD Knorr, DB Lenhart, JL AF Hindenlang, Mark D. Knorr, Daniel B. Lenhart, Joseph L. TI Improvement of polymer dielectric materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Hindenlang, Mark D.; Knorr, Daniel B.; Lenhart, Joseph L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mark.hindenlang.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 517-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303605039 ER PT J AU Hindenlang, MD Knorr, DB Richardson, A Lenhart, JL AF Hindenlang, Mark D. Knorr, Daniel B. Richardson, Adam Lenhart, Joseph L. TI Rate dependent response of crosslinked epoxy networks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Hindenlang, Mark D.; Knorr, Daniel B.; Richardson, Adam; Lenhart, Joseph L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mark.hindenlang.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 554-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303604505 ER PT J AU Hu, WG Hsieh, AJ AF Hu, Weiguo Hsieh, Alex J. TI Solid-state NMR characterization of a select model poly(urethane urea) elastomer SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. [Hsieh, Alex J.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM weiguoh@polysci.umass.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 482-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303605002 ER PT J AU Ilgen, A Majs, F Barker, A Douglas, T Trainor, T AF Ilgen, Anastasia Majs, Frantisek Barker, Amanda Douglas, Thomas Trainor, Thomas TI Oxidation and mobilization of metallic antimony in aqueous systems with simulated ground water SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Ilgen, Anastasia] Sandia Natl Labs, Dept Geochem, Albuquerque, NM 87185 USA. [Majs, Frantisek; Barker, Amanda; Trainor, Thomas] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Douglas, Thomas] US Army Corps Engineers, Cold Reg Res & Engn Lab, Fairbanks, AK 99709 USA. EM agilgen@sandia.gov NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 116-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303600363 ER PT J AU Mahdavian, E Williams-Hart, T Furmanski, B Liu, YY Kevil, C Clifford, J Salvatore, B AF Mahdavian, Elahe Williams-Hart, Tara Furmanski, Brian Liu, Yong-Yu Kevil, Christopher Clifford, John Salvatore, Brian TI Evaluation of Fusarochromanone: A potent anticancer agent SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Mahdavian, Elahe; Williams-Hart, Tara; Salvatore, Brian] LSU Shreveport, Shreveport, LA 71115 USA. [Furmanski, Brian] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA. [Liu, Yong-Yu] NE Louisiana Univ, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA. [Kevil, Christopher] LSUHSC Shreveport, Dept Pathol, Shreveport, LA USA. [Clifford, John] US Army Inst Surg Res, Battlefield Pain Control Res Program, Ft Sam Houston, TX 78234 USA. EM emahdavi@lsus.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 334-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303602353 ER PT J AU Satapathi, S Yadav, P Kumari, M Li, L Samuelson, LA Kumar, J Sharma, SK AF Satapathi, Soumitra Yadav, Preeti Kumari, Meena Li, Lian Samuelson, Lynne A. Kumar, Jayant Sharma, Sunil K. TI Two-photon active coumarins for high contrast imaging of cancer cells SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Satapathi, Soumitra; Kumar, Jayant] Univ Maasachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Yadav, Preeti; Kumari, Meena] Univ Delhi, Dept Chem, New Delhi 110007, India. [Li, Lian; Samuelson, Lynne A.; Sharma, Sunil K.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM soumitrasatapathi@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 307-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303602327 ER PT J AU St John, JM Tran, DT Oliver, SRJ AF St John, Jessica M. Tran, Dat T. Oliver, Scott R. J. TI High surface area materials for the selective desulfurization of JP-8 fuel SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Spring Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [St John, Jessica M.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. [Tran, Dat T.] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM jstjohn@ucsc.edu NR 0 TC 0 Z9 0 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 1282-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 216SF UT WOS:000324303601040 ER PT J AU Bhandari, RK Oda, RP Petrikovics, I Bebarta, VS Mohan, SB Brenner, M Rockwood, GA Logue, BA AF Bhandari, Raj K. Oda, Robert P. Petrikovics, Ilona Bebarta, Vikhyat S. Mohan, Sari B. Brenner, Matthew Rockwood, Gary A. Logue, Brian A. TI Toxicokinetics of cyanide, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid (ATCA) by simultaneous analysis using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS-MS) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Bhandari, Raj K.; Oda, Robert P.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Mohan, Sari B.] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA. [Mohan, Sari B.] Univ Calif Irvine, Med Clin, Laser Microbeam & Med Program, Irvine, CA 92612 USA. [Brenner, Matthew] Univ Calif Irvine, Div Pulm & Crit Care Med, Dept Med, Irvine, CA 92868 USA. [Bebarta, Vikhyat S.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA. EM raj.bhandari@sdstate.edu RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 15-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851300365 ER PT J AU Borodin, O Xing, LD Jow, R AF Borodin, Oleg Xing, Lidan Jow, Richard TI Electrolyte oxidative stability: Decomposition pathways and transport properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Borodin, Oleg; Jow, Richard] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Xing, Lidan] Univ Utah, Salt Lake City, UT 84112 USA. EM olegutah@gmail.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 448-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851304443 ER PT J AU Demeritte, T Ray, P Dubey, M Zarkar, E AF Demeritte, Teresa Ray, Paresh Dubey, Madan Zarkar, Eugene TI Direct detection of explosive TNT using popcorn shape gold nanoparticle attached SWCNT hybrid SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Demeritte, Teresa; Ray, Paresh] Jackson State Univ, Jackson, MS 39217 USA. [Dubey, Madan; Zarkar, Eugene] US Army Res Lab, Adelphi, MD 20783 USA. EM teresademeritte@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 33-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851300541 ER PT J AU Harrell, JE Gutteridge, CE Sadowski, BW O'Neil, MT Lee, P AF Harrell, Jonathan E. Gutteridge, Clare E. Sadowski, Brett W. O'Neil, Michael T. Lee, Patricia TI Preparation novel compounds with activity against the malaria parasite, Plasmodium falciparum SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Harrell, Jonathan E.; Gutteridge, Clare E.; Sadowski, Brett W.] US Naval Acad, Dept Chem, Annapolis, MD 21402 USA. [O'Neil, Michael T.; Lee, Patricia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM gutterid@usna.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 807-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851302604 ER PT J AU Henderson, WA Seo, DM Han, SD Allen, JL Borodin, O AF Henderson, Wesley A. Seo, Daniel M. Han, Sang-Don Allen, Joshua L. Borodin, Oleg TI Correlating solution structure to electrolyte properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Henderson, Wesley A.; Seo, Daniel M.; Han, Sang-Don; Allen, Joshua L.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM whender@ncsu.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 652-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305059 ER PT J AU Jackson, R Rockwood, GA Logue, BA AF Jackson, Randy Rockwood, Garry A. Logue, Brian A. TI Development of a field sensor for the rapid detection of cyanide exposure SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Jackson, Randy; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Garry A.] US Army Med Res Inst Chem Def, Analyt Toxicol Devis, Aberdeen Proving Ground, MD USA. EM randy.jackson@sdstate.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 75-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851300589 ER PT J AU Jacobson, LC Ren, XM Molinero, V AF Jacobson, Liam C. Ren, Xiaoming Molinero, Valeria TI Assessing the effects of crowding, pore size, and interactions on electro-osmotic drag coefficients SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Jacobson, Liam C.; Molinero, Valeria] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA. [Ren, Xiaoming] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM liam.jacobson@utah.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 732-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305134 ER PT J AU Liu, CH Pandey, R Carna, S Hussain, S AF Liu, Chinhui Pandey, Ravindra Carna, Shashi Hussain, Saber TI Modeling of lipid bilayers using first principles method SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Liu, Chinhui; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Carna, Shashi] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hussain, Saber] US Air Force Res Lab, HEPB, Dayton, OH 45433 USA. EM chinliu@mtu.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 74-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305298 ER PT J AU Liu, SC Sund, CJ Servinsky, MD Gerlach, ES AF Liu, Sanchao Sund, Christian J. Servinsky, Matthew D. Gerlach, Elliot S. TI H-1 nuclear magnetic resonance studies of arabinose and xylose metabolism in Clostridium acetobutylicium SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Liu, Sanchao; Sund, Christian J.; Servinsky, Matthew D.; Gerlach, Elliot S.] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM sanchao.liu.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 111-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851300326 ER PT J AU Mitchell, BL Rockwood, GA Logue, BA AF Mitchell, Brendan L. Rockwood, Gary A. Logue, Brian A. TI Quantification of cyanide metabolite a-ketoglutarate cyanohydrin in plasma by ultra high-performance liquid chromatography tandem mass spectrometry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Mitchell, Brendan L.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21005 USA. EM brendan.mitchell@sdstate.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 17-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851300384 ER PT J AU Stanzione, JF Sadler, JM La Scala, JJ Wool, RP AF Stanzione, Joseph F. Sadler, Joshua M. La Scala, John J. Wool, Richard P. TI Lignin-derived resins for high-performance composite applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Stanzione, Joseph F.; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Sadler, Joshua M.; La Scala, John J.] Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM jfstanz@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 241-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851301719 ER PT J AU Steevens, J Bates, M Bednar, A Chappell, M Kennedy, A Moser, R Poda, A Weiss, C AF Steevens, Jeffery Bates, Matthew Bednar, Amy Chappell, Mark Kennedy, Al Moser, Robert Poda, Aimee Weiss, Charles TI Life cycle approach for understanding risk of nanoscale materials in advanced technologies SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Steevens, Jeffery; Bates, Matthew; Bednar, Amy; Chappell, Mark; Kennedy, Al; Moser, Robert; Poda, Aimee; Weiss, Charles] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM jeffery.a.steevens@us.army.mil RI Poda, Aimee/K-1905-2012 NR 0 TC 0 Z9 0 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 69-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305293 ER PT J AU Tran, DT Chu, D AF Tran, Dat T. Chu, Deryn TI Desulfurization of JP-8 fuel using Ag/silica based adsorbents at room temperature SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Tran, Dat T.; Chu, Deryn] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 809-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305207 ER PT J AU Tuinenga, CJ Luo, HF Scott, R Kirkeminde, A Gong, MG Totleben, J Ren, SQ Chikan, V AF Tuinenga, Christopher J. Luo, Hongfu Scott, Randall Kirkeminde, Alec Gong, Maogang Totleben, Jennifer Ren, Shenqiang Chikan, Viktor TI Indium, tin, and gallium doped CdSe quantum dots for use in hybrid photovoltaic devices SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Tuinenga, Christopher J.] US Army Res Labs, RDRl WMM C, Aberdeen Proving Ground, MD 21005 USA. [Tuinenga, Christopher J.; Luo, Hongfu; Chikan, Viktor] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA. [Scott, Randall; Kirkeminde, Alec; Gong, Maogang; Totleben, Jennifer; Ren, Shenqiang] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA. EM christopher.tuinenga.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 80-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851304527 ER PT J AU Uchimiya, SM Bannon, DI AF Uchimiya, Sophie Minori Bannon, Desmond I. TI Biochar-attenuated desorption of heavy metals in small arms range soils SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Uchimiya, Sophie Minori] USDA ARS, So Reg Res Ctr, New Orleans, LA 70124 USA. [Bannon, Desmond I.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. EM sophie.uchimiya@ars.usda.gov NR 0 TC 0 Z9 0 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 118-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851305337 ER PT J AU Zhong, XL Amorim, R Scheicher, R Karna, S Pandey, R AF Zhong, Xiaoliang Amorim, Rodrigo Scheicher, Ralph Karna, Shashi Pandey, Ravindra TI Electronic transport in graphene-based heterostructures SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 245th National Meeting of the American-Chemical-Society (ACS) CY APR 07-11, 2013 CL New Orleans, LA SP Amer Chem Soc C1 [Zhong, Xiaoliang; Amorim, Rodrigo; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Scheicher, Ralph] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden. [Karna, Shashi] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM pandey@mtu.edu NR 0 TC 0 Z9 0 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 7 PY 2013 VL 245 MA 380-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 210RD UT WOS:000323851304387 ER PT J AU Izvekov, S AF Izvekov, Sergei TI Microscopic derivation of particle-based coarse-grained dynamics SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID NONEQUILIBRIUM STATISTICAL-MECHANICS; MASTER-EQUATIONS; BIOMOLECULAR SYSTEMS; LANGEVIN-EQUATIONS; OPTIMAL PREDICTION; COUPLED SYSTEMS; BROWNIAN-MOTION; QUANTUM-THEORY; SIMULATION; MEMORY AB In this paper we revisit the derivation of equations of motion for coarse-grained (CG) particles from the microscopic Hamiltonian dynamics of the underlying atomistic system in equilibrium. The derivation is based on the projection operator method and time-convolution equation. We demonstrate that due to the energy exchange between CG and intraparticle phase space coordinates in the microscopic system, the choice of projection operator is not unique, leading to different CG equations of motion that have the form of the nonlinear generalized Langevin equation (GLE). We derive the idempotence properties for the projection operators along the system trajectories and show that these properties result in streaming terms of the respective GLEs that are conservative forces and allow the expression of the non-conservative forces explicitly through thermodynamic averages, which can be measured from the microscopic simulations. The difference between GLEs that are presented herein lies in how the non-conservative forces are partitioned into dissipative and projected contributions. We compute the projected force and analyze conditions under which the projected (stochastic) force is orthogonal to (uncorrelated with) the momenta of CG particles, therefore justifying a transition to a framework of stochastic differential equations. We show that a position- and momentum-independent memory function appears only if the projected force is fully decoupled from the past CG positions and momenta, respectively. In the case of non-vanishing correlations between the projected force and the CG coordinates in past times, we derive explicitly the position- and momentum-dependent memory function in a form of projection onto a space spanned by N-order Hermite polynomials. The expressions presented herein can be used to construct a hierarchy of thermodynamically consistent CG models with momentum-dependent memory functions. They can also be used to design computational schemes for obtaining the parameters for GLEs and their variants such as dissipative particle dynamics equations from the microscopic data. We illustrate these applications by presenting the GLE with a memory function that is quadratic in the particle momenta. [http://dx.doi.org/10.1063/1.4795091] C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multi-scale Reactive Modeling of Insensitive Munitions FX The author wishes to thank Dr. Betsy Rice, Dr. John Brennan, and Dr. Joshua Moore of the Army Research Laboratory for helpful comments. This work was supported in part by the DoD High Performance Computing Modernization Program Software Application Institute for Multi-scale Reactive Modeling of Insensitive Munitions. NR 60 TC 12 Z9 12 U1 4 U2 120 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 7 PY 2013 VL 138 IS 13 AR 134106 DI 10.1063/1.4795091 PG 16 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 128SG UT WOS:000317788500006 PM 23574207 ER PT J AU Foreman, JV Simmons, JG Baughman, WE Liu, J Everitt, HO AF Foreman, J. V. Simmons, J. G., Jr. Baughman, W. E. Liu, J. Everitt, H. O. TI Localized excitons mediate defect emission in ZnO powders SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID BOUND-EXCITON; ZINC-OXIDE; PHOTOLUMINESCENCE; LUMINESCENCE; FILMS; CATHODOLUMINESCENCE; SPECTROSCOPY; DEPENDENCE; CRYSTALS; PHOSPHOR AB A series of continuous-wave spectroscopic measurements elucidates the mechanism responsible for the technologically important green emission from deep-level traps in ZnO:Zn powders. Analysis of low-temperature photoluminescence (PL) and PL excitation spectra for bound excitons compared to the temperature-dependent behavior of the green emission reveals a deep correlation between green PL and specific donor-bound excitons. Direct excitation of these bound excitons produces highly efficient green emission from near-surface defects. When normalized by the measured external quantum efficiency, the integrated PL for both excitonic and green emission features grows identically with excitation intensity, confirming the strong connection between green emission and excitons. The implications of these findings are used to circumscribe operational characteristics of doped ZnO-based white light phosphors whose quantum efficiency is almost twice as large when the bound excitons are directly excited. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4798359] C1 [Foreman, J. V.; Everitt, H. O.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. [Simmons, J. G., Jr.; Liu, J.] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Baughman, W. E.] Univ Alabama, Dept Elect & Comp Engn, Tuscaloosa, AL 35487 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Foreman, JV (reprint author), US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. EM john.v.foreman.civ@mail.mil RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU RDECOM/AMRDEC In-House Laboratory Independent Research (ILIR); Duke University; DoD SMART program FX This work was supported by RDECOM/AMRDEC In-House Laboratory Independent Research (ILIR) funding and funds from Duke University. J.G.S. acknowledges support by the DoD SMART program. NR 27 TC 11 Z9 11 U1 0 U2 52 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 7 PY 2013 VL 113 IS 13 AR 133513 DI 10.1063/1.4798359 PG 7 WC Physics, Applied SC Physics GA 121IZ UT WOS:000317238000019 ER PT J AU Madrid, PB Chopra, S Manger, ID Gilfillan, L Keepers, TR Shurtleff, AC Green, CE Iyer, LV Dilks, HH Davey, RA Kolokoltsov, AA Carrion, R Patterson, JL Bavari, S Panchal, RG Warren, TK Wells, JB Moos, WH Burke, RL Tanga, MJ AF Madrid, Peter B. Chopra, Sidharth Manger, Ian D. Gilfillan, Lynne Keepers, Tiffany R. Shurtleff, Amy C. Green, Carol E. Iyer, Lalitha V. Dilks, Holli Hutcheson Davey, Robert A. Kolokoltsov, Andrey A. Carrion, Ricardo, Jr. Patterson, Jean L. Bavari, Sina Panchal, Rekha G. Warren, Travis K. Wells, Jay B. Moos, Walter H. Burke, RaeLyn L. Tanga, Mary J. TI A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents SO PLOS ONE LA English DT Article ID VIRAL-INFECTIONS; VIRUS-INFECTION; EBOLA-VIRUS; OLD DRUGS; IN-VITRO; Q-FEVER; CHLOROQUINE; 4-AMINOQUINOLINE; CHIKUNGUNYA; HIV AB Background: The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this important goal, since currently approved drugs already have well-established safety and pharmacokinetic profiles in patients, as well as manufacturing and distribution networks. Therefore, approved drugs could rapidly be made available for a new indication in an emergency. Methodology/Principal Findings: A large systematic effort to determine whether existing drugs can be used against high containment bacterial and viral pathogens is described. We assembled and screened 1012 FDA-approved drugs for off-label broad-spectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Marburg, and Lassa fever viruses using in vitro cell culture assays. We found a variety of hits against two or more of these biological threat pathogens, which were validated in secondary assays. As expected, antibiotic compounds were highly active against bacterial agents, but we did not identify any non-antibiotic compounds with broad-spectrum antibacterial activity. Lomefloxacin and erythromycin were found to be the most potent compounds in vivo protecting mice against Bacillus anthracis challenge. While multiple virus-specific inhibitors were identified, the most noteworthy antiviral compound identified was chloroquine, which disrupted entry and replication of two or more viruses in vitro and protected mice against Ebola virus challenge in vivo. Conclusions/Significance: The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses. C1 [Madrid, Peter B.; Chopra, Sidharth; Manger, Ian D.; Gilfillan, Lynne; Keepers, Tiffany R.; Shurtleff, Amy C.; Green, Carol E.; Iyer, Lalitha V.; Dilks, Holli Hutcheson; Moos, Walter H.; Burke, RaeLyn L.; Tanga, Mary J.] SRI Int, Ctr Infect Dis & Biodefense Res, Menlo Pk, CA 94025 USA. [Davey, Robert A.; Kolokoltsov, Andrey A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Carrion, Ricardo, Jr.; Patterson, Jean L.] Texas Biomed Res Inst, San Antonio, TX USA. [Panchal, Rekha G.; Warren, Travis K.; Wells, Jay B.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Madrid, PB (reprint author), SRI Int, Ctr Infect Dis & Biodefense Res, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. EM peter.madrid@sri.com OI Chopra, Sidharth/0000-0001-8823-6074 FU Defense Threat Reduction Agency [HDTRA1-07-C-0083]; SRI International FX This work was supported by the Defense Threat Reduction Agency contract HDTRA1-07-C-0083 and internal grants of SRI International. The views expressed in this publication are those of the authors and not necessarily those of the funding organization. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 57 Z9 61 U1 5 U2 32 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 5 PY 2013 VL 8 IS 4 AR e60579 DI 10.1371/journal.pone.0060579 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 146RZ UT WOS:000319109800067 PM 23577127 ER PT J AU Apps, R Qi, Y Carlson, JM Chen, HY Gao, XJ Thomas, R Yuki, Y Del Prete, GQ Goulder, P Brumme, ZL Brumme, CJ John, M Mallal, S Nelson, G Bosch, R Heckerman, D Stein, JL Soderberg, KA Moody, MA Denny, TN Zeng, X Fang, JY Moffett, A Lifson, JD Goedert, JJ Buchbinder, S Kirk, GD Fellay, J McLaren, P Deeks, SG Pereyra, F Walker, B Michael, NL Weintrob, A Wolinsky, S Liao, W Carrington, M AF Apps, Richard Qi, Ying Carlson, Jonathan M. Chen, Haoyan Gao, Xiaojiang Thomas, Rasmi Yuki, Yuko Del Prete, Greg Q. Goulder, Philip Brumme, Zabrina L. Brumme, Chanson J. John, Mina Mallal, Simon Nelson, George Bosch, Ronald Heckerman, David Stein, Judy L. Soderberg, Kelly A. Moody, M. Anthony Denny, Thomas N. Zeng, Xue Fang, Jingyuan Moffett, Ashley Lifson, Jeffrey D. Goedert, James J. Buchbinder, Susan Kirk, Gregory D. Fellay, Jacques McLaren, Paul Deeks, Steven G. Pereyra, Florencia Walker, Bruce Michael, Nelson L. Weintrob, Amy Wolinsky, Steven Liao, Wilson Carrington, Mary TI Influence of HLA-C Expression Level on HIV Control SO SCIENCE LA English DT Article ID INFLAMMATORY-BOWEL-DISEASE; T-CELL RESPONSES; DETERMINANTS; ASSOCIATIONS; METAANALYSIS; ALLELES; SYNAPSE; ESCAPE; NUMBER AB A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease. C1 [Apps, Richard; Qi, Ying; Gao, Xiaojiang; Thomas, Rasmi; Yuki, Yuko; Carrington, Mary] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA. [Apps, Richard; Qi, Ying; Gao, Xiaojiang; Yuki, Yuko; Goulder, Philip; Pereyra, Florencia; Walker, Bruce; Carrington, Mary] Massachusetts Gen Hosp, MIT, Ragon Inst, Boston, MA 02114 USA. [Apps, Richard; Qi, Ying; Gao, Xiaojiang; Yuki, Yuko; Goulder, Philip; Pereyra, Florencia; Walker, Bruce; Carrington, Mary] Harvard Univ, Boston, MA 02114 USA. [Carlson, Jonathan M.; Heckerman, David; Zeng, Xue] Microsoft Res, ESci Grp, Los Angeles, CA 90024 USA. [Chen, Haoyan; Fang, Jingyuan; Liao, Wilson] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA. [Chen, Haoyan; Lifson, Jeffrey D.] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Dis, Dept Gastroenterol,Ren Ji Hosp, Shanghai 200001, Peoples R China. [Del Prete, Greg Q.] SAIC Frederick Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD 21702 USA. [Goulder, Philip] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa. [Goulder, Philip] Univ Oxford, Dept Paediat, Oxford OX1 3SY, England. [Brumme, Zabrina L.; Brumme, Chanson J.] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC V6Z 1Y6, Canada. [Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada. [John, Mina; Mallal, Simon] Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, WA 6150, Australia. [Nelson, George] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Ctr Canc Res Genet Core, Basic Res Program, Frederick, MD 21702 USA. [Bosch, Ronald] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA. [Stein, Judy L.; Soderberg, Kelly A.; Moody, M. Anthony; Denny, Thomas N.] Duke Univ, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Zeng, Xue] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Dermatol, Beijing 100053, Peoples R China. [Moffett, Ashley] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Goedert, James J.] NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, Bethesda, MD 20892 USA. [Buchbinder, Susan] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA. [Kirk, Gregory D.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Fellay, Jacques; McLaren, Paul] Univ Lausanne Hosp, Inst Microbiol, CH-1015 Lausanne, Switzerland. [Fellay, Jacques; McLaren, Paul] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland. [Deeks, Steven G.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94105 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Weintrob, Amy] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20817 USA. [Wolinsky, Steven] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA. RP Carrington, M (reprint author), SAIC Frederick Inc, Frederick Natl Lab Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA. EM carringm@mail.nih.gov RI Del Prete, Gregory/C-2030-2012; Moffett, Ashley/J-9754-2013; SHCS, int. coll. A/G-4083-2011; Fellay, Jacques/A-6681-2009; SHCS, all/G-4072-2011; OI Fellay, Jacques/0000-0002-8240-939X; Denny, Thomas/0000-0002-7364-8276; Wolinsky, Steven/0000-0002-9625-6697; Moody, Tony/0000-0002-3890-5855; Brumme, Chanson/0000-0003-2722-5288 FU National Institutes of Health (NIH) [HHSN261200800001E, N02-CP-55504, RO1-AI046995, R01-DA04334, R01-DA12568, R01-AI060460]; Bill & Melinda Gates Foundation [38599]; Mark and Lisa Schwartz Foundation; Wellcome Trust; NIH National Institute of Allergy and Infectious Diseases (NIAID) Center for HIV/AIDS Vaccine Immunology [U01-AI-067854]; Australian National Health and Medical Research Council [384702]; National Institutes of Health [K08AR057763, R01-DA-04334, R01-DA-12568]; Creative and Novel Ideas in HIV Research Program [P30 AI027767-24]; Swiss National Science Foundation [33CSC0-108787]; NIAID; National Cancer Institute; National Heart, Lung, and Blood Institute [UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041]; [RO1 AI087145]; [K24AI069994]; [P30 AI027763]; [UL1 RR024131]; [P30 MH62246]; [R24 AI067039] FX This study makes use of data generated by the Wellcome Trust Case Control Consortium (WTCCC); a full list of investigators who contributed to the generation of this data is available at www.wtccc.org.uk. The data reported in this paper are tabulated in the main paper and supplementary materials. Data and materials will be shared subject to institutional review board (IRB) provisions regarding patient privacy. Please contact the corresponding author. Those interested in obtaining Center for HIV/AIDS Vaccine Immunology (CHAVI) samples used in this study should contact M. C. and M. A. M. A Simple Letter Agreement for the Transfer of Materials will be executed between the institutions involved, and an IRB approval/exemption should be obtained by the recipient institution when appropriate. Clinical specimens from the Multicenter AIDS Cohort Study (MACS) are subject to the terms and conditions of the MACS Master Material Transfer Agreement for Non-Profit Institutions. The project has been funded in part with federal funds from the National Institutes of Health (NIH) under contracts HHSN261200800001E, N02-CP-55504, RO1-AI046995, R01-DA04334, R01-DA12568, and R01-AI060460. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services or the Department of Defense, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government. This research was supported in part by grants from the Bill & Melinda Gates Foundation as part of the Collaboration for AIDS Vaccine Discovery and grant ID38599, the Mark and Lisa Schwartz Foundation, the Wellcome Trust, the NIH National Institute of Allergy and Infectious Diseases (NIAID) Center for HIV/AIDS Vaccine Immunology (U01-AI-067854), and the Australian National Health and Medical Research Council (Program Grant 384702). Further funding was from the National Institutes of Health grant K08AR057763 and the Creative and Novel Ideas in HIV Research Program through a supplement to the University of Alabama at the Birmingham Center For AIDS Research funding (P30 AI027767-24), made possible by collaborative efforts of the Office of AIDS Research, NIAID, and the International AIDS Society. We thank M. Trubey and A. Lara for cytometry assistance and all the patients and investigators contributing to samples studied in the WTCCC, CHAVI, Multicenter Hemophilia Cohort Study, San Francisco City Clinic Cohort, Massachusetts General Hospital Controller Cohort, United States Military HIV Natural History Study, DC Gay Cohort Study, British Columbia HOMER cohort, Western Australian HIV Cohort Study, US AIDS Clinical Trials Group, Durban, AIDS Linked to Intravenous Experience (supported by National Institutes of Health grants R01-DA-04334 and R01-DA-12568), Swiss HIV Cohort Study (supported by the Swiss National Science Foundation grant number 33CSC0-108787), Study on the Consequences of Protease Inhibitor Era (supported by grants RO1 AI087145, K24AI069994, P30 AI027763, UL1 RR024131, P30 MH62246, and R24 AI067039), and MACS cohorts (funded by NIAID, with supplemental funding from the National Cancer Institute and the National Heart, Lung, and Blood Institute [grants UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041]. NR 25 TC 114 Z9 115 U1 2 U2 51 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD APR 5 PY 2013 VL 340 IS 6128 BP 87 EP 91 DI 10.1126/science.1232685 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 118XS UT WOS:000317061100052 PM 23559252 ER PT J AU Brudner, M Karpel, M Lear, C Chen, L Yantosca, LM Scully, C Sarraju, A Sokolovska, A Zariffard, MR Eisen, DP Mungall, BA Kotton, DN Omari, A Huang, IC Farzan, M Takahashi, K Stuart, L Stahl, GL Ezekowitz, AB Spear, GT Olinger, GG Schmidt, EV Michelow, IC AF Brudner, Matthew Karpel, Marshall Lear, Calli Chen, Li Yantosca, L. Michael Scully, Corinne Sarraju, Ashish Sokolovska, Anna Zariffard, M. Reza Eisen, Damon P. Mungall, Bruce A. Kotton, Darrell N. Omari, Amel Huang, I-Chueh Farzan, Michael Takahashi, Kazue Stuart, Lynda Stahl, Gregory L. Ezekowitz, Alan B. Spear, Gregory T. Olinger, Gene G. Schmidt, Emmett V. Michelow, Ian C. TI Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors SO PLOS ONE LA English DT Article ID MANNOSE-BINDING LECTIN; RP-C4-CYP21-TNX RCCX MODULES; POLYMERASE-CHAIN-REACTION; COPY-NUMBER VARIATIONS; WEST NILE VIRUS; ENVELOPE GLYCOPROTEINS; INFLAMMATORY RESPONSE; SURFACE GLYCOPROTEIN; FALCIPARUM-MALARIA; SERINE PROTEASE-2 AB Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to infectious diseases are more common than would be expected in human populations. Since certain immune defense molecules, such as immunoglobulins, can be exploited by invasive pathogens, we hypothesized that MBL might also enhance infections in some circumstances. Consequently, the low and intermediate MBL levels commonly found in human populations might be the result of balancing selection. Using model infection systems with pseudotyped and authentic glycosylated viruses, we demonstrated that MBL indeed enhances infection of Ebola, Hendra, Nipah and West Nile viruses in low complement conditions. Mechanistic studies with Ebola virus (EBOV) glycoprotein pseudotyped lentiviruses confirmed that MBL binds to N-linked glycan epitopes on viral surfaces in a specific manner via the MBL carbohydrate recognition domain, which is necessary for enhanced infection. MBL mediates lipid-raft-dependent macropinocytosis of EBOV via a pathway that appears to require less actin or early endosomal processing compared with the filovirus canonical endocytic pathway. Using a validated RNA interference screen, we identified C1QBP (gC1qR) as a candidate surface receptor that mediates MBL-dependent enhancement of EBOV infection. We also identified dectin-2 (CLEC6A) as a potentially novel candidate attachment factor for EBOV. Our findings support the concept of an innate immune haplotype that represents critical interactions between MBL and complement component C4 genes and that may modify susceptibility or resistance to certain glycosylated pathogens. Therefore, higher levels of native or exogenous MBL could be deleterious in the setting of relative hypocomplementemia which can occur genetically or because of immunodepletion during active infections. Our findings confirm our hypothesis that the pressure of infectious diseases may have contributed in part to evolutionary selection of MBL mutant haplotypes. C1 [Brudner, Matthew; Karpel, Marshall; Chen, Li; Yantosca, L. Michael; Sarraju, Ashish; Sokolovska, Anna; Takahashi, Kazue; Stuart, Lynda; Ezekowitz, Alan B.; Schmidt, Emmett V.; Michelow, Ian C.] Massachusetts Gen Hosp, Dept Pediat, Programs Dev Immunol, Boston, MA 02114 USA. [Lear, Calli; Scully, Corinne; Olinger, Gene G.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD USA. [Zariffard, M. Reza] Rush Univ, Dept Immunol & Microbiol, Med Ctr, Chicago, IL 60612 USA. [Eisen, Damon P.] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia. [Mungall, Bruce A.] Commonwealth Sci & Ind Res Org CSIRO Livestock In, Australian Anim Hlth Lab, Geelong, Vic, Australia. [Kotton, Darrell N.; Omari, Amel] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Huang, I-Chueh; Farzan, Michael] New England Reg Primate Res Ctr, Southborough, MA 01772 USA. [Stahl, Gregory L.] Brigham & Womens Hosp, CETRI, Boston, MA 02115 USA. [Huang, I-Chueh; Farzan, Michael; Takahashi, Kazue; Stuart, Lynda; Stahl, Gregory L.; Schmidt, Emmett V.; Michelow, Ian C.] Harvard Univ, Sch Med, Boston, MA USA. RP Schmidt, EV (reprint author), Massachusetts Gen Hosp, Dept Pediat, Programs Dev Immunol, Boston, MA 02114 USA. EM eschmidt@partners.org; ian_michelow@brown.edu OI Olinger, Gene/0000-0001-7338-0292; Kotton, Darrell/0000-0002-9604-8476 FU National Institutes of Health [U01 AI070330]; United States Department of Defense, Defense Threat Reduction Agency Biological Therapeutics Program [4.10006, 4.10007] FX This work was supported by National Institutes of Health Grant U01 AI070330 (to EVS) and by United States Department of Defense, Defense Threat Reduction Agency Biological Therapeutics Program Grants 4.10006 and 4.10007 (to GGO). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 102 TC 17 Z9 17 U1 1 U2 22 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 2 PY 2013 VL 8 IS 4 AR e60838 DI 10.1371/journal.pone.0060838 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 127RY UT WOS:000317717300151 PM 23573288 ER PT J AU Michael, NL AF Michael, Nelson L. TI Advances in Preventive HIV Vaccine Development SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Meeting Abstract CT 14th Annual International Meeting of the Institute-of-Human-Virology CY OCT 14-17, 2012 CL Univ Maryland Sch Med, Baltimore, MD SP Inst Human Virol HO Univ Maryland Sch Med C1 [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR PY 2013 VL 62 SU 1 BP 51 EP 51 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 300IQ UT WOS:000330458000042 ER PT J AU Harrison, OB Claus, H Jiang, Y Bennett, JS Bratcher, HB Jolley, KA Corton, C Care, R Poolman, JT Zollinger, WD Frasch, CE Stephens, DS Feavers, I Frosch, M Parkhill, J Vogel, U Quail, MA Bentley, SD Maiden, MCJ AF Harrison, Odile B. Claus, Heike Jiang, Ying Bennett, Julia S. Bratcher, Holly B. Jolley, Keith A. Corton, Craig Care, Rory Poolman, Jan T. Zollinger, Wendell D. Frasch, Carl E. Stephens, David S. Feavers, Ian Frosch, Matthias Parkhill, Julian Vogel, Ulrich Quail, Michael A. Bentley, Stephen D. Maiden, Martin C. J. TI Description and Nomenclature of Neisseria meningitidis Capsule Locus SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NUCLEAR-MAGNETIC-RESONANCE; MENINGOCOCCAL POLYSACCHARIDES; STRUCTURAL DETERMINATION; CHEMICAL PROPERTIES; SEROGROUP-Y; GROUP-B; ANTIGEN; BIOSYNTHESIS; GENETICS; ELUCIDATION AB Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference. C1 [Harrison, Odile B.] Univ Oxford, Dept Zool, Oxford OX1 3PS, England. [Bennett, Julia S.; Bratcher, Holly B.; Jolley, Keith A.; Maiden, Martin C. J.] Univ Oxford, Oxford OX1 3PS, England. [Claus, Heike; Frosch, Matthias; Vogel, Ulrich] Univ Wurzburg, D-97070 Wurzburg, Germany. [Jiang, Ying; Corton, Craig; Parkhill, Julian; Quail, Michael A.; Bentley, Stephen D.] Sanger Inst, Cambridge, England. [Care, Rory; Feavers, Ian] Natl Inst Biol Stand & Controls, Potters Bar, Herts, England. [Poolman, Jan T.] Crucell, Leiden, Netherlands. [Zollinger, Wendell D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Frasch, Carl E.] Frasch Biol Consulting, Martinsburg, WV USA. [Stephens, David S.] Emory Univ, Atlanta, GA 30322 USA. RP Harrison, OB (reprint author), Univ Oxford, Dept Zool, S Parks Rd, Oxford OX1 3PS, England. EM odile.harrison@zoo.ox.ac.uk RI Frosch, Matthias/H-2411-2013; Parkhill, Julian/G-4703-2011; OI Parkhill, Julian/0000-0002-7069-5958; Maiden, Martin/0000-0001-6321-5138; Jolley, Keith/0000-0002-0751-0287 FU Wellcome Trust [087622] NR 40 TC 63 Z9 65 U1 0 U2 9 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2013 VL 19 IS 4 BP 566 EP 573 DI 10.3201/eid1904.111799 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 268LV UT WOS:000328173100006 PM 23628376 ER PT J AU Fildes, JM Meyers, SJ Mulligan, CP Kilaparti, R AF Fildes, J. M. Meyers, S. J. Mulligan, C. P. Kilaparti, R. TI Evaluation of the wear and abrasion resistance of hard coatings by ball-on-three-disk test methods-A case study SO WEAR LA English DT Article DE Ball-on-three-disk; Three-body abrasion; Wear testing ID FILMS; TIN AB Engineered surfaces can provide superior resistance to abrasive and adhesive wear. There are many types of hard coatings readily available including diamond-like-carbon (DLC) coatings, nitrides, carbides, oxides, etc., and due to the many processing alternatives including alloying element, thickness, deposition technique, etc. each of these types contains a virtually endless number of choices. Fundamental materials properties such as hardness and toughness are often not adequate to reflect how a particular coating will perform, and some of these properties, toughness for example, can be hard to measure and are usually not available. In contrast, bench-scale measurements of friction and wear can provide reliable and meaningful data. However, many of these techniques are expensive and time-consuming and determining the best coating to meet the requirements of a specific application amongst this endless variety of materials can be cost-prohibitive. In this case, ball-on-three-disk (BOTD) test methods are used to provide a rapid, cost-effective, and accurate measure of the wear and abrasion resistance of representative samples of many of the types of coatings being designed with modern techniques. This work provides a case study of steel coated with seven types of nitrides, novel Cr and Ni plated coatings, as well as baseline uncoated and manganese phosphate coated steel samples. The data illustrates the value of the BOTD test method as a bench-scale tribological test as well as significant insight to how subtle design features and changes in the testing conditions of coatings can lead to significant differences in performance. (C) 2012 Elsevier B.V. All rights reserved. C1 [Fildes, J. M.; Meyers, S. J.] Inst Tribol & Coatings, Sugar Grove, IL 60554 USA. [Mulligan, C. P.] Armament Res Dev & Engn Ctr, US Army Benet Labs, Watervliet, NY 12189 USA. [Kilaparti, R.] No Illinois Univ, Coll Engn & Engn Technol, De Kalb, IL 60115 USA. RP Fildes, JM (reprint author), Inst Tribol & Coatings, 1019 Air Pk Dr, Sugar Grove, IL 60554 USA. EM jfildes@tribologyinstitute.org NR 13 TC 4 Z9 4 U1 1 U2 6 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 J9 WEAR JI Wear PD APR-MAY PY 2013 VL 302 IS 1-2 SI SI BP 1040 EP 1049 DI 10.1016/j.wear.2012.11.018 PG 10 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 195DP UT WOS:000322682800024 ER PT J AU Resio, DT Irish, JL Westerink, JJ Powell, NJ AF Resio, Donald T. Irish, Jennifer L. Westerink, Joannes J. Powell, Nancy J. TI The effect of uncertainty on estimates of hurricane surge hazards SO NATURAL HAZARDS LA English DT Article DE Storm surges; Hurricanes; Hazards; Risk; Uncertainty ID RESPONSE FUNCTION-APPROACH; WIND; INTENSITY; MODEL AB It is shown here that uncertainty can significantly affect estimated surge levels over a wide range of annual exceedance probabilities (AEPs). For AEPs in the range of 1 x 10(-2)-5 x 10(-2) in the New Orleans area, estimated surge values with and without consideration of uncertainty differ by about 0.5-1.0 m. Similarly, suppression of natural variability, such as using a single value for Mississippi River discharge in surge simulations, rather than allowing the discharge to vary probabilistically, is shown to produce deviations up to 1 m for the 1 x 10(-2) AEP in locations within the mainline river levees in this area. It is also shown that uncertainty can play a critical role in the analysis of very low probability events in the AEP range 1 x 10(-4)-1 x 10(-6). Such events are typically used in designs of structures with major societal impacts. It is shown here that, for this range of AEPs along the west coast of Florida, the neglect of uncertainty can under-predict design surge levels by about 20 % compared to estimated surge levels that include uncertainty. C1 [Resio, Donald T.] Univ N Florida, Jacksonville, FL 32224 USA. [Irish, Jennifer L.] Virginia Tech, Blacksburg, VA USA. [Westerink, Joannes J.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Powell, Nancy J.] US Army Corps Engineers Dist, New Orleans, LA USA. RP Resio, DT (reprint author), Univ N Florida, Jacksonville, FL 32224 USA. EM don.resio@unf.edu OI Irish, Jennifer/0000-0002-2429-5953 NR 16 TC 7 Z9 7 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD APR PY 2013 VL 66 IS 3 BP 1443 EP 1459 DI 10.1007/s11069-012-0315-1 PG 17 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 135UC UT WOS:000318313000010 ER PT J AU Samy, RP Gopalakrishnakone, P Satyanarayanajois, SD Stiles, BG Chow, VTK AF Samy, Ramar Perumal Gopalakrishnakone, Ponnampalam Satyanarayanajois, Seetharama D. Stiles, Bradley G. Chow, Vincent T. K. TI Snake Venom Proteins and Peptides as Novel Antibiotics Against Microbial Infections SO CURRENT PROTEOMICS LA English DT Article DE Antibiotics; antimicrobial peptides; L-amino acid oxidase; microbial infections; phospholipase A(2); snake cathelicidin ID AMINO-ACID OXIDASE; LYS49 PHOSPHOLIPASE A(2); MEMBRANE-DAMAGING ACTIVITIES; BRADYKININ-POTENTIATING PEPTIDES; CATIONIC ANTIMICROBIAL PEPTIDES; AMERICAN RATTLESNAKE VENOM; BOTHROPS-JARARACUSSU VENOM; DURISSUS-TERRIFICUS VENOM; MANNOSE-BINDING LECTIN; HOST-DEFENSE PEPTIDES AB Animals produce a large variety of antimicrobial peptides that play an important role in natural innate immunity and controlling microbial infections. Snakes are classified into the phylum Chordata and class Reptilia, within the animal kingdom. Snake venoms are extensive mixtures that contain a large number of biologically active proteins/peptides that represent a promising source of potential therapeutics for both humans and animals. These components are extensively studied for a wide range of pharmacological properties; however, it is quite exceptional that very little is relatively known about antimicrobial activity associated with venoms to date. In this review, we emphasize the available literature linked to antimicrobial activity of venom proteins such as L-amino acid oxidase (LAAO), phospholipase A(2) (PLA(2)), peptides and snake cathelicidin. We propose a model for antimicrobial action in comparison with existing mechanisms. Structure and function of snake venom proteins/peptides in relation to antimicrobial activity and its involvement in molecular pharmacology thoroughly discussed. Nevertheless, snake venom enzymes and various classes of peptides have unique pharmacological properties, enhanced properties of antimicrobial effects against various bacterial infections, as well as varying levels of toxicity on eukaryotic and prokaryotic cells. In conclusions, these peptide-based molecules may ultimately be used as alternative drugs to replace chemical antibiotics that increasingly become less useful due to highly-evolved resistance mechanisms employed by various microbial pathogens. C1 [Samy, Ramar Perumal; Chow, Vincent T. K.] Natl Univ Singapore, Natl Univ Hlth Syst, Dept Microbiol, Singapore 117597, Singapore. [Samy, Ramar Perumal; Gopalakrishnakone, Ponnampalam] Natl Univ Singapore, Natl Univ Hlth Syst, Dept Anat, Venom & Toxin Res Program, Singapore 117597, Singapore. [Satyanarayanajois, Seetharama D.] Univ Louisiana, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71291 USA. [Stiles, Bradley G.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. RP Samy, RP (reprint author), Natl Univ Singapore, Natl Univ Hlth Syst, Dept Microbiol, MD 4,5 Sci Dr 2, Singapore 117597, Singapore. EM micrama@nus.edu.sg FU Proof Of Concept (POC), Economic Development Board (EDB) grant WBS, Singapore [R - 181 000 110 141] FX This work was supported by Proof Of Concept (POC), Economic Development Board (EDB) grant WBS No: R - 181 000 110 141, Singapore. NR 171 TC 4 Z9 4 U1 2 U2 20 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1570-1646 EI 1875-6247 J9 CURR PROTEOMICS JI Curr. Proteomics PD APR PY 2013 VL 10 IS 1 BP 10 EP 28 PG 19 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 171IH UT WOS:000320918600003 ER PT J AU Russell, D Bettoli, PW AF Russell, Drew Bettoli, Phillip W. TI Population Attributes of Lake Trout in Tennessee Reservoirs SO SOUTHEASTERN NATURALIST LA English DT Article ID SALVELINUS-NAMAYCUSH; THERMAL HABITAT; GROWTH; FISH; SUPERIOR; MODEL; ECOLOGY; ONTARIO; BIOLOGY; CHAR AB We sampled stocked Salvelinus namaycush (Lake Trout) in Watauga Lake and South Holston Lake, TN using experimental gill nets in 2009-2010 to describe their growth, longevity, and condition. Annuli in sagittal otoliths formed once a year in early spring in both reservoirs. South Holston Lake (n = 99 Lake Trout) has been stocked since 2006, and the oldest fish was age 4. Watauga Lake has been stocked since the mid-1980s, and we collected 158 Lake Trout up to age 20. Annual mortality for age-3 and older fish in Watauga Lake was 24%. When compared to Lake Trout in northern lakes, Tennessee Lake Trout exhibited average to above-average growth and longevity. Condition of Lake Trout in both reservoirs varied seasonally and tended to be lowest in fall, but rebounded in winter and spring. Lake Trout in both reservoirs appeared to be spatially segregated from pelagic prey fishes during summer stratification, but growth rates and body condition were high enough to suggest that neither system was being overstocked. C1 [Russell, Drew; Bettoli, Phillip W.] Tennessee Technol Univ, Tennessee Cooperat Fishery Res Unit, Cookeville, TN 38505 USA. RP Russell, D (reprint author), USA, Corps Engineers, 600 Dr Martin Luther King Pl, Louisville, KY 40202 USA. EM drussell20@gmail.com FU Tennessee Wildlife Resources Agency; Center for the Management, Utilization, and Protection of Water Resources at Tennessee Technological University (TTU); USGS Tennessee Cooperative Fishery Research Unit FX The use of trade, product, industry, or firm names or products is for informative purposes only and does not constitute an endorsement by the US Government or the US Geological Survey. Funding for this research was provided by the Tennessee Wildlife Resources Agency, the Center for the Management, Utilization, and Protection of Water Resources at Tennessee Technological University (TTU), and the USGS Tennessee Cooperative Fishery Research Unit. We extend our thanks to J. Hammonds and S. Henagar for their help in the field, as well as the many TTU graduate students and anglers (especially Rob and Mary Kelly) who volunteered their time and fish carcasses, respectively. This manuscript benefited from constructive comments on earlier drafts by H.T. Mattingly, H.T. Andrews, S. Reeser, M.C. Quist, and two anonymous reviewers. NR 50 TC 0 Z9 0 U1 1 U2 12 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PD APR PY 2013 VL 12 IS 1 BP 217 EP 232 DI 10.1656/058.012.0117 PG 16 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 184DY UT WOS:000321868900017 ER PT J AU Diana, JS Egna, HS Chopin, T Peterson, MS Cao, L Pomeroy, R Verdegem, M Slack, WT Bondad-Reantaso, MG Cabello, F AF Diana, James S. Egna, Hillary S. Chopin, Thierry Peterson, Mark S. Cao, Ling Pomeroy, Robert Verdegem, Marc Slack, William T. Bondad-Reantaso, Melba G. Cabello, Felipe TI Responsible Aquaculture in 2050: Valuing Local Conditions and Human Innovations Will Be Key to Success SO BIOSCIENCE LA English DT Article DE human capacity development; integrated multitrophic aquaculture; best management practices; recirculating aquaculture systems; responsible aquaculture ID LIFE-CYCLE ASSESSMENT; OREOCHROMIS-NILOTICUS; MARINE AQUACULTURE; ANIMAL HEALTH; SYSTEMS; IMPROVEMENT; POPULATION; FISH; TECHNOLOGIES; BIODIVERSITY AB As aquaculture production expands, we must avoid mistakes made during increasing intensification of agriculture. Understanding environmental impacts and measures to mitigate them is important for designing responsible aquaculture production systems. There are four realistic goals that can make future aquaculture operations more sustainable and productive: (I) improvement of management practices to create more efficient and diverse systems at every production level; (2) emphasis on local decisionmaking, human capacity development, and collective action to generate productive aquaculture systems that fit into societal constraints and demands; (3) development of risk management efforts for all systems that reduce disease problems, eliminate antibiotic and drug abuse, and prevent exotic organism introduction into local waters; and (4) creation of systems to better identify more sustainably grown aquaculture products in the market and promote them to individual consumers. By 2050, seafood will be predominantly sourced through aquaculture, including not only finfish and invertebrates but also seaweeds. C1 [Diana, James S.; Cao, Ling] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. [Egna, Hillary S.] Oregon State Univ, Aquaculture & Fisheries Collaborat Res Support Pr, Corvallis, OR 97331 USA. [Chopin, Thierry] Univ New Brunswick, Canadian Integrated Multitroph Aquaculture Networ, St John, NB E2L 4L5, Canada. [Peterson, Mark S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA. [Pomeroy, Robert] Univ Connecticut, Groton, CT USA. [Verdegem, Marc] Wageningen Univ, Aquaculture & Fisheries Grp, NL-6700 AP Wageningen, Netherlands. [Slack, William T.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Bondad-Reantaso, Melba G.] UN, FAO, Dept Fisheries & Aquaculture, Rome, Italy. [Cabello, Felipe] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA. RP Diana, JS (reprint author), Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. EM jimd@umich.edu RI Verdegem, marc/C-6659-2014; Chopin, Thierry/L-9532-2015 OI Verdegem, marc/0000-0002-2058-3894; Chopin, Thierry/0000-0003-2981-7324 FU US Agency for International Development Cooperative Agreement Leader with Associates through the Aquaculture and Fisheries Collaborative Research Support Program (Aqua Fish CRSP) [EPP-A-00-06-00012-00] FX This article is the outcome of a workshop and symposium presentation entitled "The effects of semi-intensive aquaculture on biodiversity in nearshore and inland waters," which was held at the annual meeting of the American Fisheries Society in September 2011. Financial support for this symposium was from US Agency for International Development Cooperative Agreement Leader with Associates grant no. EPP-A-00-06-00012-00 through the Aquaculture and Fisheries Collaborative Research Support Program (Aqua Fish CRSP) and also by participating institutions. This is contribution no. 1399 of the Aqua Fish CRSP. NR 56 TC 29 Z9 29 U1 9 U2 108 PU AMER INST BIOLOGICAL SCI PI WASHINGTON PA 1444 EYE ST, NW, STE 200, WASHINGTON, DC 20005 USA SN 0006-3568 J9 BIOSCIENCE JI Bioscience PD APR PY 2013 VL 63 IS 4 BP 255 EP 262 DI 10.1525/bio.2013.63.4.5 PG 8 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 165NX UT WOS:000320491700011 ER PT J AU Gates, DH Aldridge, JM Wilken, JM AF Gates, Deanna H. Aldridge, Jennifer M. Wilken, Jason M. TI Kinematic comparison of walking on uneven ground using powered and unpowered prostheses SO CLINICAL BIOMECHANICS LA English DT Article DE Gait; Transtibial amputation; Prosthetic feet; Uneven terrain ID DESTABILIZING ROCK SURFACE; HUMAN JOINT MOTION; TRANSTIBIAL AMPUTATIONS; ISB RECOMMENDATION; GAIT; ANKLE; SYSTEM; DEFINITIONS; AMPUTEES; KINETICS AB Background: Recent research has focused on the design of intelligent prosthetic ankle devices with the goal of adapting behavior of the device to accommodate all walking surfaces that an individual encounters in daily life. To date, no studies have looked at how such devices perform on uneven terrain. Methods: 11 young adults with unilateral transtibial amputation participated in two data collection sessions spaced approximately 3 weeks apart. In each session they walked across a loose rock surface at three controlled speeds. In the first session, they wore a passive, energy storage and return prosthesis and in the second, they wore a powered prosthesis (BiOM, iWalk, Bedford, MA, USA). Findings: Subjects had a 10% faster self-selected walking speed when wearing the powered (1.16 m/s) compared to unpowered prosthesis (1.05 m/s; p = 0.031). They walked with increased ankle plantarflexion on their prosthetic limb throughout the gait cycle when wearing the powered compared to unpowered prosthesis. This was especially evident in the increased plantarflexion during push-off (p < 0.001). There was a small (<3 degrees), but statistically significant decrease in knee flexion during early stance when wearing the powered device (p = 0.045). Otherwise, the kinematics of the knee and hip were nearly identical when wearing the different devices. Subjects had decreased medial-lateral motion of their center of mass when wearing the powered prosthesis (p = 0.020), but there were no differences in medial-lateral margins of stability between the devices (p = 0.662). Interpretation: Subjects did not significantly alter their proximal joint kinematics on this irregular surface as a result of the addition of power. Published by Elsevier Ltd. C1 [Gates, Deanna H.; Aldridge, Jennifer M.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM Jason.wilken@us.army.mil OI Wilken, Jason/0000-0002-5556-7667 FU U.S. Army Telemedicine & Advanced Technology Research Center; Center for Rehabilitation Sciences Research FX Partial support was provided by the U.S. Army Telemedicine & Advanced Technology Research Center and the Center for Rehabilitation Sciences Research. We would like to thank Jordan Sturdy for his help with data processing and the CFI prosthetics team for their contribution to this effort. NR 26 TC 8 Z9 8 U1 4 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 J9 CLIN BIOMECH JI Clin. Biomech. PD APR PY 2013 VL 28 IS 4 BP 467 EP 472 DI 10.1016/j.clinbiomech.2013.03.005 PG 6 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA 170CD UT WOS:000320826300017 PM 23602128 ER PT J AU Hockersmith, EE Brooks, G Dumdei, ND Achord, S AF Hockersmith, Eric E. Brooks, Gabriel Dumdei, Nathan D. Achord, Stephen TI A Lightweight Battery for Backpack Electrofishing SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article AB A lithium ion battery was modified to replace the conventional sealed lead acid battery used to operate a backpack electrofishing unit. Specifications and performance of the lithium ion battery were compared with those of a lead acid battery of similar capacity. The lithium ion battery was 76% lighter in weight than the lead acid battery, reducing the overall weight of a Smith-Root model 12 backpack electrofishing unit and battery by 55%. Including the cost of a charger and parts to make the battery compatible with an electroshocking unit, the lithium ion battery and charger cost was 26% less than that of the lead acid battery and charger. Bench tests indicated the lithium ion battery provided 91% and 98% of the operating time of the lead acid battery per charge when the settings were 300V at 90Hz and 500V at 90Hz, respectively. The fuel gauge (battery discharge indicator) on the lithium ion battery, which was absent in the lead acid battery, provided the ability for a user to assess the remaining charge level while in the field. The lithium ion battery provided similar performance with a significant reduction in weight and cost compared with a conventional lead acid battery for backpack electrofishing. The lighter weight of the backpack electrofishing unit using the lithium ion battery can reduce fatigue and the risk of fatigue-related injuries to field crews. C1 [Hockersmith, Eric E.] US Army Corp Engineers, Northwestern Div, Walla Walla, WA 99362 USA. [Brooks, Gabriel; Dumdei, Nathan D.; Achord, Stephen] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Fish Ecol Div, Seattle, WA 98112 USA. RP Hockersmith, EE (reprint author), US Army Corp Engineers, Northwestern Div, 201 North 3rd, Walla Walla, WA 99362 USA. EM eric.e.hockersmith@usace.army.mil FU U.S. Department of Energy, Bonneville Power Administration (BPA), Portland, Oregon [004981] FX This work was funded in part by the U.S. Department of Energy, Bonneville Power Administration (BPA), Portland, Oregon (contract 004981). We thank the following for their assistance in conducting this study: Deborah Docherty from BPA, and Gordon Axel, Shane Collier, John Ferguson, Bruce Jonasson, Jesse Lamb, Kenneth McIntyre, Jeff Moser, Richard Nelson, Matthew Nesbit, Neil Paasch, Sam Rambo, and Louis Tullos from the National Marine Fisheries Service. Reference to trade names does not imply endorsement by the U.S. Government. NR 8 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD APR 1 PY 2013 VL 33 IS 2 BP 265 EP 268 DI 10.1080/02755947.2013.765526 PG 4 WC Fisheries SC Fisheries GA 167PD UT WOS:000320643000004 ER PT J AU Thomas, MJ Peterson, ML Friedenberg, N Van Eenennaam, JP Johnson, JR Hoover, JJ Klimley, AP AF Thomas, Michael J. Peterson, Matthew L. Friedenberg, Nick Van Eenennaam, Joel P. Johnson, Joseph R. Hoover, Jan Jeffrey Klimley, A. Peter TI Stranding of Spawning Run Green Sturgeon in the Sacramento River: Post-Rescue Movements and Potential Population-Level Effects SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID ACIPENSER-MEDIROSTRIS; LIFE-HISTORY; MIGRATION; CALIFORNIA; PATTERNS; KLAMATH; ENTRAINMENT; HABITAT; SIZE; RISK AB The lower portion of the Sacramento River, California, has been highly engineered to protect low-lying surrounding communities from annual flood events. While engineered floodplains have provided adequate protection for the surrounding communities, there remain unintended consequences to migratory fish that become stranded during high flow events. In April 2011, we rescued 24 threatened Green Sturgeon Acipenser medirostris that were stranded in two flood diversions along the Sacramento River. We tagged these 24 Green Sturgeon with acoustic tags and analyzed their survival and migration success to their spawning grounds. Additionally, we provided a population viability analysis to show the potential impacts of stranding and the benefits of conducting rescues at the population level. We found that 17 of these 24 individuals continued their upstream migration to the spawning grounds. Modeling suggests that recurrent stranding of a similar magnitude without rescue could affect the long-term viability of Green Sturgeon in the Sacramento River. Population viability analyses of rescue predicted a 7% decrease below the population baseline model over 50years as opposed to 33% without rescue. Despite the mitigated impact to the population with rescue, fish passage improvements should be considered as a long-term goal for preventing population risks at flood control diversions. C1 [Thomas, Michael J.; Peterson, Matthew L.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fisheries & Conservat Biol, Biotelemetry Lab, Davis, CA 95616 USA. [Peterson, Matthew L.] FISHBIO, Chico, CA 95928 USA. [Friedenberg, Nick] Appl Biomath, Setauket, NY 11733 USA. [Van Eenennaam, Joel P.] Univ Calif Davis, Finfish Reprod Physiol Lab, Dept Anim Sci, Davis, CA 95616 USA. [Johnson, Joseph R.] Calif Dept Fish & Game, Rancho Cordova, CA 95670 USA. [Hoover, Jan Jeffrey] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Thomas, MJ (reprint author), Univ Calif Davis, Dept Wildlife Fisheries & Conservat Biol, Biotelemetry Lab, 1 Shields Ave, Davis, CA 95616 USA. EM mjthomas@ucdavis.edu FU U.S. Army Corps of Engineers, Sacramento District FX We are grateful to the many staff members and volunteers of the California Department of Fish and Game for their exhaustive efforts to capture and return sturgeon back to the river. Without the foresight of agency personnel to include a telemetry component to the rescue, this study would not have been possible. Tagging support was provided by Brian Mahardja and Emily Miller from University of California, Davis, and Robert Chase from the U.S. Bureau of Reclamation. Funding for population modeling was provided by the U.S. Army Corps of Engineers, Sacramento District. Permission to publish was provided by the Chief of Engineers. NR 33 TC 4 Z9 3 U1 0 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD APR 1 PY 2013 VL 33 IS 2 BP 287 EP 297 DI 10.1080/02755947.2012.758201 PG 11 WC Fisheries SC Fisheries GA 167PD UT WOS:000320643000007 ER PT J AU Bijl, P Maurer, T Wilson, DL AF Bijl, Piet Maurer, Tana Wilson, David L. TI Target Search and Detection SO OPTICAL ENGINEERING LA English DT Editorial Material C1 [Bijl, Piet] TNO BSS Human Factors, NL-3769 ZG Soesterberg, Netherlands. [Maurer, Tana; Wilson, David L.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Bijl, P (reprint author), TNO BSS Human Factors, Kampweg 5, NL-3769 ZG Soesterberg, Netherlands. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 2013 VL 52 IS 4 AR 041101 DI 10.1117/1.OE.52.4.041101 PG 1 WC Optics SC Optics GA 151DB UT WOS:000319439700004 ER PT J AU Camp, HA Moyer, S Moore, RK AF Camp, H. Alan Moyer, Steve Moore, Richard K. TI Performance characteristics of the masked target transform volume clutter metric SO OPTICAL ENGINEERING LA English DT Article DE clutter metric; masked target transform volume ID ACQUISITION PERFORMANCE AB Prior work has shown that the masked target transform volume (MTTV) clutter metric provides a measure of scene clutter that better correlates to measured probability of detection for human observers than several previously published clutter metrics. Several factors involved in using the MTTV to assess clutter in imagery are discussed here. A previously published modification to the MTTV metric to provide a normalized output value comparable across different image sets regardless of scene size is reviewed. Initial MTTV development required knowledge of a scene's target signature and produced an unbounded metric value. Metric behavior is discussed for the case in which an average of several target signatures is used in place of a specific target signature. This allows the MTTV to be calculated for images that do not contain a target. It is shown that the user may trade computational efficiency with metric accuracy to suit a particular application. The sensitivity of the metric to variations in image noise level, target segmentation error, and viewing distance are also presented. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 [Camp, H. Alan] EOIR Technol Inc, Fredericksburg, VA 22408 USA. [Moyer, Steve] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Moore, Richard K.] USA, ATEC, Redstone Test Ctr, Redstone Arsenal, AL 35898 USA. RP Camp, HA (reprint author), EOIR Technol Inc, Fredericksburg, VA 22408 USA. EM hacamp@eoir.com NR 20 TC 0 Z9 0 U1 0 U2 2 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 2013 VL 52 IS 4 AR 041104 DI 10.1117/1.OE.52.4.041104 PG 9 WC Optics SC Optics GA 151DB UT WOS:000319439700007 ER PT J AU Maurer, T Wilson, DL Driggers, RG AF Maurer, Tana Wilson, David L. Driggers, Ronald G. TI Search and detection modeling of military imaging systems SO OPTICAL ENGINEERING LA English DT Article DE search; target acquisition; target detection; ACQUIRE; ACQUIRE-LC; DETECT-05; search time; time-limited search; clutter; image-based modeling; targeting task performance metric ID TIME-LIMITED SEARCH; PERFORMANCE; VISION; IMPROVEMENTS; CLUTTER AB For more than 50 years, the U. S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) has been studying the science behind the human processes of searching and detecting, and using that knowledge to develop and refine its models for military imaging systems. Modeling how human observers perform military tasks while using imaging systems in the field and linking that model with the physics of the systems has resulted in the comprehensive sensor models we have today. These models are used by the government, military, industry, and academia for sensor development, sensor system acquisition, military tactics development, and war-gaming. From the original hypothesis put forth by John Johnson in 1958, to modeling time-limited search, to modeling the impact of motion on target detection, to modeling target acquisition performance in different spectral bands, the concept of search has a wide-ranging history. Our purpose is to present a snapshot of that history; as such, it will begin with a description of the search-modeling task, followed by a summary of highlights from the early years, and concluding with a discussion of search and detection modeling today and the changing battlefield. Some of the topics to be discussed will be classic search, clutter, computational vision models and the ACQUIRE model with its variants. We do not claim to present a complete history here, but rather a look at some of the work that has been done, and this is meant to be an introduction to an extensive amount of work on a complex topic. That said, it is hoped that this overview of the history of search and detection modeling of military imaging systems pursued by NVESD directly, or in association with other government agencies or contractors, will provide both the novice and experienced search modeler with a useful historical summary and an introduction to current issues and future challenges. c 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Maurer, Tana; Wilson, David L.] USA, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command, CERDEC, Ft Belvoir, VA 22060 USA. [Driggers, Ronald G.] USN, Res Lab, Washington, DC 20375 USA. RP Maurer, T (reprint author), USA, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command, CERDEC, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 37 TC 5 Z9 5 U1 0 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 2013 VL 52 IS 4 AR 041108 DI 10.1117/1.OE.52.4.041108 PG 11 WC Optics SC Optics GA 151DB UT WOS:000319439700011 ER PT J AU Vollmerhausen, RH Driggers, RG Hodgkin, VA AF Vollmerhausen, Richard H. Driggers, Ronald G. Hodgkin, Van A. TI Night illumination in the near- and short-wave infrared spectral bands and the potential for silicon and indium-gallium-arsenide imagers to perform night targeting SO OPTICAL ENGINEERING LA English DT Article DE airglow; night illumination; night vision imaging; silicon focal plane array; indium-gallium-arsenide ID WIND IMAGING INTERFEROMETER; AIRGLOW EMISSIONS; TIDAL INFLUENCE; MESOSPHERIC OH; TEMPERATURES; O-2; SATELLITE; OXYGEN; MODEL AB On a moonless night, the primary source of natural illumination in the near infrared and short-wave infrared spectral bands is airglow. We use data gathered by astronomers and atmospheric scientists to estimate the magnitude and variability of airglow ground illumination. Based on that foundation, we analyze the target acquisition performance of imagers that use silicon and indium-gallium-arsenide focal plane arrays. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Vollmerhausen, Richard H.] Univ Delaware, Newark, DE 19716 USA. [Driggers, Ronald G.] USN, Res Lab, Washington, DC 20375 USA. [Hodgkin, Van A.] USA, Res & Dev Command, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Vollmerhausen, RH (reprint author), Univ Delaware, Newark, DE 19716 USA. EM vollmerhausen@hughes.net FU U.S. Army Research and Development Command, Night Vision and Electronic-Sensors Directorate at Fort Belvoir, Virginia FX This work has been funded by the U.S. Army Research and Development Command, Night Vision and Electronic-Sensors Directorate at Fort Belvoir, Virginia. NR 48 TC 2 Z9 2 U1 1 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD APR PY 2013 VL 52 IS 4 AR 043202 DI 10.1117/1.OE.52.4.043202 PG 8 WC Optics SC Optics GA 151DB UT WOS:000319439700015 ER PT J AU Andrew, SP Beidleman, BA Fulco, CS Yates, BA Muza, SR AF Andrew, Sean P. Beidleman, Beth A. Fulco, Charles S. Yates, Brandon A. Muza, Stephen R. TI Two days of staging at moderate altitude results in similar time-trial performance impairments at 4300m compared to direct ascent and stay for two days at 4300m SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Andrew, Sean P.; Beidleman, Beth A.; Fulco, Charles S.; Yates, Brandon A.; Muza, Stephen R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 715.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503545 ER PT J AU Arsenault, JE Noyes, M Funderburk, L AF Arsenault, Joanne E. Noyes, Michael Funderburk, LesLee TI Attitudes and behaviors of overweight or obese US Army Soldiers SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Arsenault, Joanne E.] RTI Int, Res Triangle Pk, NC USA. [Noyes, Michael] 163rd Med Battal, Seoul, South Korea. [Funderburk, LesLee] William Beaumont Army Med Ctr, Ft Bliss, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 349.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501546 ER PT J AU Austin, KG McGraw, SM Lieberman, H AF Austin, Krista Gail McGraw, Susan M. Lieberman, Harris TI Dietary supplement use is associated with positive mood states in US Military and Coast Guard personnel SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Austin, Krista Gail; McGraw, Susan M.; Lieberman, Harris] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 242.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501530 ER PT J AU Banwarth, EA McAllister, E Rothschadl, K Wampfler, A Mendis, C Jett, M AF Banwarth, Emily Anne McAllister, Erin Rothschadl, Kendra Wampfler, Ashlynne Mendis, Chanaka Jett, Marti TI Effect of Pathway-Interconnectors in SEB-Induced Apoptosis Related Events in Human PBMCs SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Banwarth, Emily Anne; McAllister, Erin; Rothschadl, Kendra; Wampfler, Ashlynne; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] USA, Ctr Environm Hlth Res, Syst Biol Enterprise USA Med Command MEDCOM, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 604.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883500627 ER PT J AU Beidleman, BA Fulco, CS Kenefick, RW Cymerman, A Staab, JE Muza, SR AF Beidleman, Beth A. Fulco, Charles S. Kenefick, Robert W. Cymerman, Allen Staab, Janet E. Muza, Stephen R. TI Two Days of Staging at Moderate Altitude Reduces Acute Mountain Sickness Upon Further Ascent to 4300 m in Unacclimatized Lowlanders SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Beidleman, Beth A.; Fulco, Charles S.; Kenefick, Robert W.; Cymerman, Allen; Staab, Janet E.; Muza, Stephen R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 715.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503345 ER PT J AU Biedenkapp, J Grohmann, K McClung, J Farina, E Murphy, N Cummings, C Lieberman, H AF Biedenkapp, Joseph Grohmann, Kyle McClung, James Farina, Emily Murphy, Nancy Cummings, Christopher Lieberman, Harris TI Biochemical and mood changes dissociate during exposure to intense military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Biedenkapp, Joseph; McClung, James; Farina, Emily; Murphy, Nancy; Cummings, Christopher; Lieberman, Harris] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Biedenkapp, Joseph; Farina, Emily; Cummings, Christopher] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Grohmann, Kyle] USA, John F Kennedy Special Warfare Ctr, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 936.12 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860506225 ER PT J AU Blake, CE Rosemond, TN Torres-McGehee, TM Frongillo, EA Burke, MP Lenkerd, A Minton, DM Cable, LTCS Glover, SH AF Blake, Christine E. Rosemond, Tiara N. Torres-McGehee, Toni M. Frongillo, Edward A. Burke, Michael P. Lenkerd, Allison Minton, Dawn M. Cable, L. T. C. Sonya Glover, Saundra H. TI Drill Sergeants' two contrasting approaches to "soldierization" and instilling healthy eating behaviors in soldiers SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Blake, Christine E.; Rosemond, Tiara N.; Torres-McGehee, Toni M.; Frongillo, Edward A.; Burke, Michael P.; Lenkerd, Allison; Minton, Dawn M.; Glover, Saundra H.] Univ S Carolina, Columbia, SC 29208 USA. [Cable, L. T. C. Sonya] USA, Initial Mil Training Ctr Excellence, Ft Eustis, VA USA. RI Blake, Christine/F-2277-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 231.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883503377 ER PT J AU Borkovec, AR Koltermann, K Martin, A Mendis, C Jett, M AF Borkovec, Ashley Rose Koltermann, Kayla Martin, Ashley Mendis, Chanaka Jett, Marti TI Early Intervention by Targeting Inhibitors of Multiple Signal Transduction Pathways in LPS Induced Human PBMCs SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Borkovec, Ashley Rose; Koltermann, Kayla; Martin, Ashley; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] USA, Ctr Environm Hlth Res, Syst Biol Enterprise US Army Med Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 604.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501611 ER PT J AU Bowman, P Bynum, JA McFaul, SJ AF Bowman, Phillip Bynum, James A. McFaul, Steve J. TI The genetic response of human endothelial cells to exposure to varying oxygen concentration. SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Bowman, Phillip; Bynum, James A.; McFaul, Steve J.] USA, Inst Surg Res, DCR, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 717.10 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860505088 ER PT J AU Bowman, P Bynum, JA McFaul, SJ AF Bowman, Phillip Bynum, James A. McFaul, Steve J. TI An In Vitro Hypoxia/Reoxygenation Model of Ischemia/Reperfusion Injury with Glucose Oxidase And Catalase SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Bowman, Phillip; Bynum, James A.; McFaul, Steve J.] USA, Inst Surg Res, DCR, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 717.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503115 ER PT J AU Bukhari, AS Young, AJ McGraw, SM Roberts, SB Das, SK AF Bukhari, Asma Sultana Young, Andrew J. McGraw, Susan M. Roberts, Susan B. Das, Sai Krupa TI Level of Interest in a Weight Management Program Among Adult US Military Dependents SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Bukhari, Asma Sultana; Young, Andrew J.; McGraw, Susan M.] USA, Inst Environm Med USARIEM, Mil Nutr Dept, Natick, MA 01760 USA. [Roberts, Susan B.; Das, Sai Krupa] Tufts Univ, Energy Metab Lab, JM, HNRCA,USDA, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 854.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883503294 ER PT J AU Cao, J Pasiakos, SM Margolis, LM Whigham, LD McClung, JP Young, AJ Combs, GF AF Cao, Jay Pasiakos, Stefan M. Margolis, Lee M. Whigham, Leah D. McClung, James P. Young, Andrew J. Combs, Gerald F. TI Calcium homeostasis and bone metabolic responses to protein diets and energy restriction: a randomized control trial SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Cao, Jay; Whigham, Leah D.; Combs, Gerald F.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. [Pasiakos, Stefan M.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 249.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883503199 ER PT J AU Carbone, JW Margolis, LM McClung, JP Cao, JJ Young, AJ Pasiakos, SM AF Carbone, John Walter Margolis, Lee M. McClung, James P. Cao, Jay J. Young, Andrew J. Pasiakos, Stefan M. TI Energy intake modulates intramuscular mTORC1 signaling and ubiquitin-mediated proteolysis during energy deficit independent of dietary protein variations SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Carbone, John Walter] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. [Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Cao, Jay J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 631.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883505212 ER PT J AU Clarke, DC Zhou, D Inman, W Barker, CJ Leon, LR Lauffenburger, DA AF Clarke, David C. Zhou, Dennis Inman, Walker Barker, Caroline J. Leon, Lisa R. Lauffenburger, Douglas A. TI A computer-controlled system for simulating heat stroke in vitro SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Clarke, David C.; Zhou, Dennis; Inman, Walker; Barker, Caroline J.; Lauffenburger, Douglas A.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Leon, Lisa R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1201.8 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500472 ER PT J AU Dubick, MA Klemcke, HG Grubbs, DL Barr, JL Rose, R AF Dubick, Michael A. Klemcke, Harold G. Grubbs, Dana L. Barr, Johnny L. Rose, Rajiv TI Tissue antioxidant status in hemorrhaged inbred rat strains fed diets for 9 weeks varying in levels of methyl group donors SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Dubick, Michael A.; Klemcke, Harold G.; Grubbs, Dana L.; Barr, Johnny L.; Rose, Rajiv] USA, DCR, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1193.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502422 ER PT J AU Farina, EK Grohmann, K Biedenkapp, JC McClung, JP Lieberman, HR AF Farina, Emily Kristin Grohmann, Kyle Biedenkapp, Joseph C. McClung, James P. Lieberman, Harris R. TI Baseline serum n-3 eicosapentaenoic acid concentration is associated with subsequent mood disturbance during the acute stress of military survival school training SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Farina, Emily Kristin; Biedenkapp, Joseph C.; McClung, James P.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Farina, Emily Kristin; Biedenkapp, Joseph C.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Grohmann, Kyle] USA, John F Kennedy Special Warfare Ctr, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1072.18 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883505011 ER PT J AU Hamilton, LR Myers, TM AF Hamilton, Lindsey R. Myers, Todd M. TI Bioscavengers to protect against chemical warfare nerve agents: safety of adenovirus-driven expression of butyrylcholinesterase in macaques SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Hamilton, Lindsey R.; Myers, Todd M.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 662.8 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502210 ER PT J AU Harvey, R Barnes, JN Charkoudian, N Curry, TB Eisenach, JH Hart, ECJ Joyner, MJ AF Harvey, Ronee Barnes, Jill N. Charkoudian, Nisha Curry, Timothy B. Eisenach, John H. Hart, Emma C. J. Joyner, Michael J. TI Forearm vasodilator response to isoproterenol in premenopausal and postmenopausal women SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Harvey, Ronee] Mayo Clin, Coll Med, Rochester, MN USA. [Barnes, Jill N.; Curry, Timothy B.; Eisenach, John H.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Hart, Emma C. J.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 927.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860504554 ER PT J AU Hinojosa-Laborde, C Shade, R Muniz, G Bauer, C Convertino, V AF Hinojosa-Laborde, Carmen Shade, Robert Muniz, Gary Bauer, Cassondra Convertino, Victor TI Comparison of hemodynamic responses to lower body negative pressure and hemorrhage in baboons SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Hinojosa-Laborde, Carmen; Muniz, Gary; Convertino, Victor] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Shade, Robert; Bauer, Cassondra] Texas Biomed Res Inst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1206.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502428 ER PT J AU Houle, KE Kantner, BJ Brechue, WF AF Houle, Katherine E. Kantner, Bryan J. Brechue, William F. TI Dissociation of recovery of muscle activation and force following a sustained maximal isometric contraction SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Houle, Katherine E.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Kantner, Bryan J.] Philadelphia Coll Osteopat Med, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1152.19 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500062 ER PT J AU Hughes, JM Fellin, RE Walker, LA Frykman, PN Seay, JF AF Hughes, Julie Marie Fellin, Rebecca Elizabeth Walker, Leila Anne Frykman, Peter Northrop Seay, Joseph Francis TI Greater peak oxygen consumption is associated with lower bone strength in soldiers SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Hughes, Julie Marie; Fellin, Rebecca Elizabeth; Walker, Leila Anne; Frykman, Peter Northrop; Seay, Joseph Francis] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 941.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502317 ER PT J AU Jaligama, S Kale, VM Wilbanks, MS Perkins, EJ Meyer, SA AF Jaligama, Sridhar Kale, Vijay M. Wilbanks, Mitchell S. Perkins, Edward J. Meyer, Sharon A. TI Bone marrow inflammation precedes hexahydro-1-nitroso-3, 5-dinitro-1, 3, 5-triazine (MNX) induced delayed myelosuppression in rats. SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Jaligama, Sridhar; Meyer, Sharon A.] Univ Louisiana Monroe, Monroe, LA USA. [Kale, Vijay M.] Roseman Univ Hlth Sci, South Jordan, UT USA. [Wilbanks, Mitchell S.; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RI Jaligama, Sridhar/D-5533-2015 OI Jaligama, Sridhar/0000-0001-6374-3336 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 888.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500285 ER PT J AU Jibitu, M AF Jibitu, Meskerem TI Psycho-Physiological Changes in Mouse Strain Submitted to Social Stress SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Jibitu, Meskerem] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 936.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860506217 ER PT J AU Johnson, BD van Helmond, N Curry, TB Convertino, VA Joyner, MJ AF Johnson, Blair David van Helmond, Noud Curry, Timothy B. Convertino, Victor A. Joyner, Michael J. TI Hemodynamic responses during lower body negative pressure and hemorrhage in humans SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Johnson, Blair David; van Helmond, Noud; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA. [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1206.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500474 ER PT J AU Kajih, T Smith, J Rusek, T Kasten, S Cerasoli, D AF Kajih, Takwen Smith, John Rusek, Tom Kasten, Shane Cerasoli, Douglas TI A Single Gas Chromatography/Mass Spectrometry Method for Detection of Individual Enantiomers of a Broad Spectrum of G-Type Chemical Warfare Nerve Agents SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Kajih, Takwen; Smith, John; Rusek, Tom; Kasten, Shane; Cerasoli, Douglas] USA, Med Res Inst Chem Def, Edgewood, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 7 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 559.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883500190 ER PT J AU Kang, BH Racicot, K Kwon, YI Apostolidis, E AF Kang, Bou-Hee Racicot, Kenneth Kwon, Young-In Apostolidis, Emmanouil TI Evaluation of in vitro anti-hyperglycemic effect of Cinnamon cassia derived phenolic phytochemicals SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Kang, Bou-Hee; Apostolidis, Emmanouil] Framingham State Univ, Framingham, MA USA. [Racicot, Kenneth] USA, Natick Soldier Res Engn Ctr, Natick, MA 01760 USA. [Kwon, Young-In] Hannam Univ, Taejon, South Korea. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 637.19 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883505473 ER PT J AU Kay, VL George, M Soller, BR Ryan, KL Hinojosa-Laborde, C Convertino, VA Rickards, CA AF Kay, Victoria Lee George, Mebin Soller, Babs R. Ryan, Kathy L. Hinojosa-Laborde, Carmen Convertino, Victor A. Rickards, Caroline A. TI The role of differential oxygen distribution between the brain and peripheral tissues on tolerance to induced central hypovolemia SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Kay, Victoria Lee; Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA. [George, Mebin] ISS Inc, Champaign, IL USA. [Soller, Babs R.] Reflectance Med Inc, Westborough, MA USA. [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA lb667 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860506298 ER PT J AU Leon, LR Dineen, SM Clarke, DC AF Leon, Lisa R. Dineen, Shauna M. Clarke, David C. TI Early Activation of Liver Apoptotic Signaling Pathways during Heat Stroke Recovery in Mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Leon, Lisa R.; Dineen, Shauna M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Clarke, David C.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Clarke, David C.] MIT, Ctr Cellular Decis Proc, Cambridge, MA 02139 USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1201.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503278 ER PT J AU Leon, LR Duran, RM Helwig, BG AF Leon, Lisa R. Duran, Rocio M. Helwig, Bryan G. TI Complementing Heat Stroke: Activation and Amplification of the IL-6 and Complement System during Heat Stroke Recovery in F344 Rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Leon, Lisa R.; Duran, Rocio M.; Helwig, Bryan G.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1201.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500105 ER PT J AU Lynch, CM Matheny, RW AF Lynch, Christine M. Matheny, Ronald W. TI Lysophosphatidic acid-mediated phosphorylation of protein kinase D2 is dependent on PKC delta SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Lynch, Christine M.; Matheny, Ronald W.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 831.16 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883504371 ER PT J AU Margolis, LM Cao, JJ Whigham, LD McClung, JP Combs, GF Young, AJ Pasiakos, SM AF Margolis, Lee M. Cao, Jay J. Whigham, Leah D. McClung, James P. Combs, Gerald F. Young, Andrew J. Pasiakos, Stefan M. TI Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled trial SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, MND, Environm Med Res Inst, Natick, MA 01760 USA. [Cao, Jay J.; Whigham, Leah D.; Combs, Gerald F.] ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1075.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860504577 ER PT J AU McClung, JP Gaffney-Stomberg, E Lutz, LJ Rood, JC Cable, SJ Pasiakos, SM Young, AJ AF McClung, James P. Gaffney-Stomberg, Erin Lutz, Laura J. Rood, Jennifer C. Cable, Sonya J. Pasiakos, Stefan M. Young, Andrew J. TI Associations between vitamin D status and lipid profiles in military recruits SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [McClung, James P.; Gaffney-Stomberg, Erin; Lutz, Laura J.; Pasiakos, Stefan M.; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 635.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883502481 ER PT J AU Moore, NLT Gauchan, S Genovese, RF AF Moore, Nicole L. T. Gauchan, Sangeeta Genovese, Raymond F. TI Adolescent traumatic stress experience shapes adulthood fear conditioning and extinction responses SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Moore, Nicole L. T.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 661.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860504251 ER PT J AU Moyler, C Wolf, DW Oberbaum, M Dorozko, M Ives, JA Muhie, S Miller, SA Jonas, WB Jett, M Hammamieh, R AF Moyler, Candace Wolf, Dana W. Oberbaum, M. Dorozko, M. Ives, John A. Muhie, Seid Miller, Stacy A. Jonas, Wayne B. Jett, Marti Hammamieh, Rasha TI Gripp-Heel and the Antiviral Host-Cell Responses against Adenovirus SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Moyler, Candace; Muhie, Seid; Miller, Stacy A.; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Wolf, Dana W.; Dorozko, M.] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel. [Oberbaum, M.] Shaare Zedek Med Ctr, Jerusalem, Israel. [Ives, John A.; Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 6 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 773.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501342 ER PT J AU Murphy, NE Lin, GG Wulff, CR Gaffney-Stomberg, E Young, AJ McClung, JP Pasiakos, SM AF Murphy, Nancy E. Lin, Gregory G. Wulff, Charles R. Gaffney-Stomberg, Erin Young, Andrew J. McClung, James P. Pasiakos, Stefan M. TI Divergent intramuscular mTORC1 signaling responses to habitual consumption of milk-and soy-based energy restricted diets SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Murphy, Nancy E.; Lin, Gregory G.; Wulff, Charles R.; Gaffney-Stomberg, Erin; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 631.9 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501306 ER PT J AU Muza, SR Kenefick, RW Andrew, SP Beidleman, BA Fulco, CS Hamilton, SW AF Muza, Stephen Raymond Kenefick, Robert W. Andrew, Sean P. Beidleman, Beth A. Fulco, Charles S. Hamilton, Scott W. TI Altitude acclimatization and acute mountain sickness during a graded ascent to 5896 m SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Muza, Stephen Raymond; Kenefick, Robert W.; Andrew, Sean P.; Beidleman, Beth A.; Fulco, Charles S.; Hamilton, Scott W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 715.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502239 ER PT J AU Oh, T Klemcke, HG AF Oh, T. Klemcke, H. G. TI Cardiac CARD9 mRNA expression in inbred rat strains divergent in survival time after severe hemorrhage (STaH) SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Oh, T.; Klemcke, H. G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1212.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860501182 ER PT J AU Park, BS Henning, PC Khamoui, AV Jo, E Lee, SR Zourdos, MC Kim, DH Yeh, MC Kim, JS AF Park, Bong-Sup Henning, Paul C. Khamoui, Andy V. Jo, Edward Lee, Sang-Rok Zourdos, Michael C. Kim, Do-Houn Yeh, Ming-Chia Kim, Jeong-Su TI HMB Attenuates A Loss of Myofiber Cross-Sectional Area during Prolonged Exercise with Calorie Restriction by Enhancing Regenerative Capacity SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Park, Bong-Sup; Khamoui, Andy V.; Jo, Edward; Kim, Do-Houn; Yeh, Ming-Chia; Kim, Jeong-Su] Florida State Univ, Tallahassee, FL 32306 USA. [Henning, Paul C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Lee, Sang-Rok] Univ Memphis, Memphis, TN 38152 USA. [Zourdos, Michael C.] Florida Atlantic Univ, Boca Raton, FL 33431 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1076.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883503166 ER PT J AU Pasiakos, SM Wulff, CR Murphy, NE Gaffney-Stomberg, E Young, AJ McClung, JP AF Pasiakos, Stefan M. Wulff, Charles R. Murphy, Nancy E. Gaffney-Stomberg, Erin Young, Andrew J. McClung, James P. TI High protein diets enhance body composition in rats: a comparative analysis of milk-and soy-based energy restricted diets SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Pasiakos, Stefan M.; Wulff, Charles R.; Murphy, Nancy E.; Gaffney-Stomberg, Erin; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 631.10 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501623 ER PT J AU Quinn, CM Helwig, BG Leon, LR Ward, JA Duran, RM AF Quinn, Carrie M. Helwig, Bryan G. Leon, Lisa R. Ward, Jermaine A. Duran, Rocio M. TI Efficacy of Geranylgeranylacetone for heat stroke recovery in Fischer 344 rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Quinn, Carrie M.; Helwig, Bryan G.; Leon, Lisa R.; Ward, Jermaine A.; Duran, Rocio M.] USA, Thermal Mt Med Div, Inst Environm Med, Natick, MA 01760 USA. RI Quinn, Carrie/A-2558-2014 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1201.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503048 ER PT J AU Racicot, K Arcidiacono, S Chen, CY Soares, J AF Racicot, Kenneth Arcidiacono, Steven Chen, C. Y. (Oliver) Soares, Jason TI The impact of long-term storage on fermentability of human fecal bacteria SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Racicot, Kenneth] USA, Combat Feeding Directorate, Natick Soldier Ctr, Natick, MA 01760 USA. [Arcidiacono, Steven; Soares, Jason] USA, Warrior Sci & Tech Dir, Natick Soldier Ctr, Natick, MA 01760 USA. [Racicot, Kenneth; Chen, C. Y. (Oliver)] Tufts Univ, Jean Mayer Human Nutr Res Ctr Aging, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 9 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1056.13 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860501401 ER PT J AU Rastogi, A Stavchansky, S Bowman, P AF Rastogi, Ashish Stavchansky, Salomon Bowman, Phillip TI Dependence of cytotoxicity of menadione and cytoprotection by antioxidants in human endothelial cells on oxygen levels: Atmospheric oxygen versus physiological levels SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Rastogi, Ashish; Bowman, Phillip] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rastogi, Ashish] Geneva Fdn, Tacoma, WA USA. [Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1143.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860504592 ER PT J AU Reed, E AF Reed, Eddie TI Translational Nucleotide Excision Repair in Triple Negative Breast Cancer SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Reed, Eddie] USA, Mitchell Canc Inst, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 328.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500152 ER PT J AU Santos, WJ Waddy, E Chakraborty, N Gautam, A Hoke, A Jett, M Hammamieh, R AF Santos, William J. Waddy, Edward Chakraborty, Nabarun Gautam, Aarti Hoke, Allison Jett, Marti Hammamieh, Rasha TI Pan-omic Approaches to Study the Effect of Microgravity on Skin Endothelial Cells Submitted to Endotoxic Insult SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Santos, William J.; Waddy, Edward; Chakraborty, Nabarun; Gautam, Aarti; Hoke, Allison; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 9 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 773.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883500288 ER PT J AU Schwacha, MG Rani, M Zhang, Q AF Schwacha, Martin G. Rani, Meenakshi Zhang, Qiong TI Gamma delta T-cells regulate myeloid cell activity after injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Schwacha, Martin G.; Rani, Meenakshi; Zhang, Qiong] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schwacha, Martin G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 648.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503311 ER PT J AU Scrimgeour, AG Joosen, MJ Young, AJ van Helden, HH AF Scrimgeour, Angus Gray Joosen, Marloes J. Young, Andrew J. van Helden, Herman H. TI Euglycemia following IED-like blast exposure SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Scrimgeour, Angus Gray; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Joosen, Marloes J.; van Helden, Herman H.] TNO Def Safety & Secur, Rijswijk, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 690.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502487 ER PT J AU Shade, RE Hinojosa-Laborde, C Muniz, G Bauer, C Convertino, V AF Shade, Robert E. Hinojosa-Laborde, Carmen Muniz, Gary Bauer, Cassondra Convertino, Victor TI Comparison of neurohumoral responses to lower body negative pressure and hemorrhage in baboons SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Shade, Robert E.; Bauer, Cassondra] Texas Biomed Res Inst, San Antonio, TX USA. [Hinojosa-Laborde, Carmen; Muniz, Gary; Convertino, Victor] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1206.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500107 ER PT J AU Srinivasan, S Sowe, B Miller, SA Muhie, S Chakraborty, N Hammamieh, R Meyerhoff, J Jett, M AF Srinivasan, Seshamalini Sowe, Bintu Miller, Stacy-Ann Muhie, Seid Chakraborty, Nabarun Hammamieh, Rasha Meyerhoff, James Jett, Marti TI Correlation between Genotypes and Behavioral Phenotypes in a Mouse Model simulating aspects of Human Post-traumatic Stress Disorder (PTSD) SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Srinivasan, Seshamalini; Sowe, Bintu; Miller, Stacy-Ann; Muhie, Seid; Chakraborty, Nabarun; Hammamieh, Rasha; Meyerhoff, James; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 12 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 569.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883500199 ER PT J AU Staab, JE Beidleman, BA Fulco, CS Grunbeck, MR Guerriere, K Raeburn, J Muza, SR AF Staab, Janet E. Beidleman, Beth A. Fulco, Charles S. Grunbeck, Marie R. Guerriere, Katelyn Raeburn, Jennifer Muza, Stephen R. TI Two days of staging at moderate altitude induces 65-75% of the ventilatory acclimatization achieved with two days of continuous residence at 4300 m SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Staab, Janet E.; Beidleman, Beth A.; Fulco, Charles S.; Grunbeck, Marie R.; Guerriere, Katelyn; Raeburn, Jennifer; Muza, Stephen R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 715.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860504108 ER PT J AU Stallings, JD Rakeesh, V Helwig, BG Baer, CE Lewis, JA Leon, LR Reifman, J Jackson, DA AF Stallings, Jonathan Daniel Rakeesh, Vineet Helwig, Bryan G. Baer, Christine E. Lewis, John A. Leon, Lisa R. Reifman, Jaques Jackson, David A. TI Gene array analysis reveals consensus heat stress response in rat liver, lung, heart, and kidney SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Stallings, Jonathan Daniel; Baer, Christine E.; Lewis, John A.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Rakeesh, Vineet; Reifman, Jaques] Biotechnol HPC Software Applicat Inst, Frederick, MD USA. [Helwig, Bryan G.; Leon, Lisa R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI Jackson, David/E-9984-2014 NR 0 TC 0 Z9 0 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA lb780 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860505321 ER PT J AU Tharion, WJ Yokota, M AF Tharion, William J. Yokota, Miyo TI Energy expenditure of military helicopter air crews during combat missions assessed by modified factorial method. SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Tharion, William J.; Yokota, Miyo] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 854.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 157GG UT WOS:000319883501037 ER PT J AU Torres, I Torres, L Sondeen, J Ji, L Dubick, M AF Torres Filho, Ivo Torres, Luciana Sondeen, Jill Ji, Lisa Dubick, Michael TI Effects of Resuscitation Fluids following Hemorrhagic Shock on Venular Glycocalyx in Rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Torres Filho, Ivo; Torres, Luciana; Sondeen, Jill; Ji, Lisa; Dubick, Michael] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 900.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503578 ER PT J AU Torres, L Sondeen, J Ji, L Dubick, M Torres, I AF Torres, Luciana Sondeen, Jill Ji, Lisa Dubick, Michael Torres Filho, Ivo TI Effects of resuscitation fluids on endothelial glycocalyx (EG) and coagulation in severe hemorrhagic shock (HS) SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Torres, Luciana; Sondeen, Jill; Ji, Lisa; Dubick, Michael; Torres Filho, Ivo] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 900.10 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503382 ER PT J AU Urso, ML Carrigan, CT Warren, GL AF Urso, Maria L. Carrigan, Christopher T. Warren, Gordon L. TI Matrix Metalloprotease Inhibition Negatively Affects Signaling Required for Muscle Regeneration Post-traumatic Injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Urso, Maria L.; Carrigan, Christopher T.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Warren, Gordon L.] Georgia State Univ, Dept Phys Therapy, Atlanta, GA 30303 USA. RI Warren, Gordon/A-9794-2008 OI Warren, Gordon/0000-0002-7073-8524 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 939.18 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860503182 ER PT J AU Urso, ML Lee, AJ Leon, LR AF Urso, Maria L. Lee, Andrew J. Leon, Lisa R. TI Heat stroke induces a local inflammatory response in skeletal muscle of mice during 24 hours of recovery SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Urso, Maria L.; Lee, Andrew J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Leon, Lisa R.] USA, Thermal Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 942.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500327 ER PT J AU van Helmond, N Johnson, BD Curry, TB Convertino, VA Joyner, MJ AF van Helmond, Noud Johnson, Blair D. Curry, Timothy B. Convertino, Victor A. Joyner, Michael J. TI The Association between Pulse Pressure and Stroke Volume during Lower Body Negative Pressure and Graded Hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA. [Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1206.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860501176 ER PT J AU Yokota, M Karis, AJ Goetz, VC Tharion, WJ AF Yokota, Miyo Karis, Anthony J. Goetz, Victoria C. Tharion, William J. TI Evaluation of physiological strain in law enforcement personnel wearing protective clothing and equipment SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Yokota, Miyo; Karis, Anthony J.; Goetz, Victoria C.; Tharion, William J.] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1201.9 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860502426 ER PT J AU Patterson, MS Gray, JP Bortolin, G Vantsevich, VV AF Patterson, Michael S. Gray, Jeremy P. Bortolin, Gianantonio Vantsevich, Vladimir V. TI Fusion of driving and braking tire operational modes and analysis of traction dynamics and energy efficiency of a 4 x 4 loader SO JOURNAL OF TERRAMECHANICS LA English DT Article DE 4 x 4 Loader single bucket loader; Brake-based traction control; Interwheel limited slip differentials; Fusion; Math and computer models; Traction and energy efficiency ID ROAD AB Brake-based traction control systems (TCs), which utilize the brake of a spinning wheel, are widely used in various vehicles. Recently, TCs were applied to all-wheel drive construction equipment. Such machines employ various types of driveline systems to control torque split between the drive wheels and thus improve vehicle traction performance. As experimental research showed, the interaction between the TC system and the axle drive can lead to unpredictable changes in vehicle traction. Lack of analytical work motivated a study of the interaction/impact of the two systems on each other and then traction a 4 x 4 single bucket loader. This paper presents an analytical and computer model of the loader's driveline system. Mechanical power distributions between the driving wheels are analyzed when a brake mechanism of a spinning wheel is on/off. Computer simulations were conducted on surfaces with different grip conditions of the four wheels, with longitudinal and lateral inclination of the loader when scooping the material. The paper discusses simulation results and presents fundamentals for the fusion of the driveline and TC systems to improve the loader's traction. (c) 2013 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Patterson, Michael S.; Gray, Jeremy P.] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI USA. [Bortolin, Gianantonio] Volvo Construct Equipment AB, Eskilstuna, Sweden. [Vantsevich, Vladimir V.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. RP Vantsevich, VV (reprint author), Univ Alabama Birmingham, 1720 2nd Ave South, Birmingham, AL 35294 USA. EM vantsevi@uab.edu NR 24 TC 10 Z9 10 U1 2 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2013 VL 50 IS 2 BP 133 EP 152 DI 10.1016/j.jterra.2013.01.003 PG 20 WC Engineering, Environmental SC Engineering GA 150DK UT WOS:000319370200006 ER PT J AU Voloshinov, VB Knyazev, GA Kulakova, LA Gupta, N AF Voloshinov, V. B. Knyazev, G. A. Kulakova, L. A. Gupta, N. TI Acousto-optic control of light beams in the infrared range SO PHYSICS OF WAVE PHENOMENA LA English DT Article ID CRYSTALS; HG2CL2 AB The control over the parameters of the far-infrared and terahertz radiation by the acoustooptic method is discussed. The operation of a tunable acousto-optic filter based on the tellurium crystal is investigated. The crystal used in the filter was transparent for the optic radiation in the wavelength range of 4.0 to 23 A mu m. The device allows electronic tuning and processing of optic images in the spectral interval of 8.0 to 14 A mu m. C1 [Voloshinov, V. B.; Knyazev, G. A.] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119991, Russia. [Kulakova, L. A.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia. [Gupta, N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Voloshinov, VB (reprint author), Moscow MV Lomonosov State Univ, Fac Phys, Leninskie Gory 1-2, Moscow 119991, Russia. EM volosh@phys.msu.ru; g_knyazev@mail.ru; L.Kulakova@mail.ioffe.ru; neelam.gupta.civ@mail.mil FU RFBR [12-02-01119-a, 11-02-00681-a, 10-07-00683, 10-07-00623]; CRDF [RUP 1-1663-MO-06] FX The work was supported by RFBR Projects 12-02-01119-a, 11-02-00681-a, 10-07-00683, and 10-07-00623, and by the CRDF Grant RUP 1-1663-MO-06. NR 12 TC 1 Z9 1 U1 0 U2 5 PU ALLERTON PRESS INC PI NEW YORK PA 18 WEST 27TH ST, NEW YORK, NY 10001 USA SN 1541-308X J9 PHYS WAVE PHENOM JI Phys. Wave Phenom. PD APR PY 2013 VL 21 IS 2 BP 134 EP 138 DI 10.3103/S1541308X13020052 PG 5 WC Physics, Multidisciplinary SC Physics GA 151PH UT WOS:000319472100005 ER PT J AU Datta, A Yeo, H Norman, TR AF Datta, Anubhav Yeo, Hyeonsoo Norman, Thomas R. TI Experimental Investigation and Fundamental Understanding of a Full-Scale Slowed Rotor at High Advance Ratios SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID COMPOUND HELICOPTER; TECHNOLOGY AB This paper describes and analyzes the measurements from a full-scale, slowed revolutions per minute (rpm), UH-60A rotor tested at the National Full-Scale Aerodynamics Complex 40- by 80-ft wind tunnel up to an advance ratio of 1.0. A comprehensive set of measurements that includes performance, blade loads, hub loads, and pressures/airloads makes this data set unique. The measurements reveal new and rich aeromechanical phenomena that are unique to this exotic regime. These include reverse chord dynamic stall, retreating side impulse in torsion load, large inboard outboard elastic twist differential, diminishing rotor forces and yet a dramatic buildup of blade loads, and high blade loads and yet benign levels of vibratory hub loads. The objective of this research is the fundamental understanding of these unique aeromechanical phenomena. The intent is to provide useful knowledge for the design of high-speed, high-efficiency, slowed rpm rotors of the future and a database for validation of advanced analyses. C1 [Datta, Anubhav] NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. [Yeo, Hyeonsoo] NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA. [Norman, Thomas R.] NASA, Ames Res Ctr, Aeromech Branch, Moffett Field, CA 94035 USA. RP Datta, A (reprint author), NASA, Ames Res Ctr, Sci & Technol Corp, USA,Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. EM hubloads@gmail.com NR 39 TC 10 Z9 10 U1 0 U2 7 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2013 VL 58 IS 2 AR 022004 DI 10.4050/JAHS.58.022004 PG 17 WC Engineering, Aerospace SC Engineering GA 147NF UT WOS:000319173600004 ER PT J AU Yeo, H Romander, EA AF Yeo, Hyeonsoo Romander, Ethan A. TI Loads Correlation of a Full-Scale UH-60A Air loads Rotor in a Wind Tunnel SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID COMPREHENSIVE ANALYSIS; HELICOPTER ROTORS; AIRLOADS; PERFORMANCE; PREDICTION; SYSTEM AB Wind tunnel measurements of the rotor trim, blade airloads, and structural loads of a full-scale UH-60A Black Hawk main rotor are compared with calculations obtained using the comprehensive rotorcraft analysis CAMRAD II and a coupled CAMRAD II/OVERFLOW 2 analysis. A speed sweep at constant lift up to an advance ratio of 0.4 and a thrust sweep at constant speed into deep stall are investigated. The coupled analysis shows significant improvement over comprehensive analysis. Normal force phase is better captured for all the test conditions examined. Pitching moment is better predicted, including the magnitude and phase of the two stall events in the fourth quadrant at the deeply stalled condition. Structural loads are, in general, improved with the coupled analysis, but the magnitude of chord bending moment is still significantly underpredicted. As there are three modes around 4 and 5/rev frequencies, the structural responses to the 5/rev airloads due to dynamic stall are magnified and thus accurate analysis of the deeply stalled condition is challenging. C1 [Yeo, Hyeonsoo] NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA. [Romander, Ethan A.] NASA, Ames Res Ctr, Flight Vehicle Res & Technol Div, Moffett Field, CA 94035 USA. RP Yeo, H (reprint author), NASA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, USA,Res Dev & Engn Command, Moffett Field, CA 94035 USA. EM hyeonsoo.yeo.civ@mail.mil NR 20 TC 1 Z9 1 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2013 VL 58 IS 2 DI 10.4050/JAHS.58.022003 PG 18 WC Engineering, Aerospace SC Engineering GA 147NF UT WOS:000319173600003 ER PT J AU Cohen, RL Li, YZ Giese, R Mancuso, JD AF Cohen, Robert L. Li, Yuanzhang Giese, Russell Mancuso, James D. TI An Evaluation of the President's Emergency Plan for AIDS Relief Effect on Health Systems Strengthening in Sub-Saharan Africa SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE PEPFAR; health systems strengthening; TB; child mortality; infant mortality; life expectancy ID TUBERCULOSIS; INITIATIVES; TRENDS; BURDEN AB Background: President's Emergency Plan for AIDS Relief (PEPFAR) has been criticized for its vertical or "stove-piping" structure, with resources targeting a specific disease rather than working to strengthen the underlying health system. This study aimed to evaluate whether PEPFAR activities were associated with system-wide improvements in both proximal and distal indicators of health systems strengthening. Methods: The World Bank database provided 12 indicators of health systems strengthening that were analyzed for their relationship to PEPFAR. Poisson and linear regression models were used to estimate the time trend. We evaluated the PEPFAR impact on health outcomes by comparing the time trend in each of the above indicators between 2 time periods: from 1995 to 2002 (pre-PEPFAR) and from 2004 to 2010 (during PEPFAR). Results: PEPFAR activities showed strong and statistically significant associations with improvements in proximal indicators of health systems strengthening, those related directly to HIV, specifically life expectancy (P = 0.003) and tuberculosis incidence, prevalence, and mortality (P < 0.0001). There were nonsignificant associations between PEPFAR and improvements in distal indicators of health systems strengthening, namely infant mortality and under 5 child mortality. Conclusions: The progressive scale-up of PEPFAR-supported activities was associated with consistent improvements in proximal indicators of health systems strengthening. It was also associated with improvements in broader measures of health system strength, most clearly life expectancy. Given the limited number of health measures available for this type of analysis, more data must be collected for other indicators to evaluate the effectiveness of the many multibillion dollar global health initiatives. C1 [Cohen, Robert L.; Li, Yuanzhang; Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD 20910 USA. [Giese, Russell] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU US Department of Defense via the Walter Reed Army Institute of Research FX Funding was provided by the US Department of Defense via the Walter Reed Army Institute of Research. NR 33 TC 6 Z9 6 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 1 PY 2013 VL 62 IS 4 BP 471 EP 479 DI 10.1097/QAI.0b013e3182816a86 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 145SM UT WOS:000319037700020 PM 23254150 ER PT J AU Psotka, J AF Psotka, Joseph TI Educational Games and Virtual Reality as Disruptive Technologies SO EDUCATIONAL TECHNOLOGY & SOCIETY LA English DT Article DE Disruptive technology; Educational games; Virtual reality; Modules; Assessment; Leadership ID SCIENCE AB New technologies often have the potential for disrupting existing established practices, but nowhere is this so pertinent as in education and training today. And yet, education has been glacially slow to adopt these changes in a large scale way, and innovations seem to be imposed mainly by students' and their changing social lifestyles than by policy. Will this change? Leadership is sorely needed. Education needs to become more modular and move out of the classroom into informal settings, homes, and especially the interne. Nationwide certifications based on these modules would permit technology to enter education more rapidly. Smaller nations may be more flexible in making these very disruptive changes. C1 USA, Res Inst Behav & Social Sci, Rockville, MD 20854 USA. RP Psotka, J (reprint author), USA, Res Inst Behav & Social Sci, 1436 Fallsmead Way, Rockville, MD 20854 USA. EM Psotka@msn.com NR 38 TC 9 Z9 10 U1 1 U2 21 PU IEEE COMPUTER SOC, LEARNING TECHNOLOGY TASK FORCE PI PALMERSTON NORTH PA BAG 11-222, MASSEY UNIVERSITY, PALMERSTON NORTH, NEW ZEALAND SN 1436-4522 J9 EDUC TECHNOL SOC JI Educ. Technol. Soc. PD APR PY 2013 VL 16 IS 2 BP 69 EP 80 PG 12 WC Education & Educational Research SC Education & Educational Research GA 142VO UT WOS:000318825900007 ER PT J AU Docherty, A Menyuk, CR Cahill, JP Okusaga, O Zhou, WM AF Docherty, Andrew Menyuk, Curtis R. Cahill, James P. Okusaga, Olukayode Zhou, Weimin TI Rayleigh-Scattering-Induced RIN and Amplitude-to-Phase Conversion as a Source of Length-Dependent Phase Noise in OEOs SO IEEE PHOTONICS JOURNAL LA English DT Article DE Optoelectronic oscillators (OEOs); flicker noise; optical scattering noise ID OPTOELECTRONIC MICROWAVE-OSCILLATORS; FREQUENCY; STABILITY AB Optoelectronic oscillators (OEOs) are hybrid RF-photonic oscillators that promise to be environmentally robust frequency sources with very low phase noise. Recent experiments have shown that the excess flicker phase noise in these systems grows with the length of the optical fiber loop. In this paper, we detail a mechanism for this length-dependent flicker noise in which Rayleigh-scattering-induced amplitude noise in the optical fiber combines with amplitude-to-phase noise conversion in the nonlinear electronic components. We derive an analytic model of the loop noise that includes these effects and verify this model by comparing it to numerical calculations and experimental results. C1 [Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. [Cahill, James P.; Okusaga, Olukayode; Zhou, Weimin] USA, Res Lab, Adelphi, MD 20783 USA. RP Docherty, A (reprint author), Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. EM docherty@gmail.com NR 23 TC 7 Z9 7 U1 0 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1943-0655 EI 1943-0647 J9 IEEE PHOTONICS J JI IEEE Photonics J. PD APR PY 2013 VL 5 IS 2 AR 5500514 DI 10.1109/JPHOT.2013.2250940 PG 14 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 139IC UT WOS:000318574700049 ER PT J AU Griffith, J West, C AF Griffith, James West, Courtney TI Master Resilience Training and Its Relationship to Individual Well-Being and Stress Buffering Among Army National Guard Soldiers SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH LA English DT Article ID MENTAL-HEALTH PROBLEMS; SOCIAL SUPPORT; LIFE EVENTS; COMBAT; DEPLOYMENT; IRAQ; AFGHANISTAN; DEPRESSION; SYMPTOMS; DISORDER AB To better enable soldiers to adapt to stressors of military life, Master Resilience Training has been offered to soldiers since 2009. Few studies have examined whether the training achieves its intended effects. To fill this gap, resilience-trained Army National Guard soldiers and civilians (N = 611) completed online questionnaires about their resilience training experience (72% completion rate, N = 441). Respondents (92% or more) indicated the training was helpful and improved resilience competencies that enhanced coping with stressful circumstances. Respondents (97% or more) indicated that these competencies were subsequently used in their military and civilian jobs. A measure of resilience competencies was developed and showed self-reported changes largely pertained to increased self-awareness and strength of character, including improved optimism, mental agility, and connection with others. Self-reported change in resilience competencies was associated with fewer behavioral health symptoms, especially, for those reporting more current stressful events (known as the buffering effect). Findings are discussed in terms of resilience's potency of training, content of the training, and the need to elaborate on resilience's relationship to specific stressors. C1 [Griffith, James; West, Courtney] USA, Natl Guard Bur, Soldier & Family Support Div, Arlington, VA USA. RP Griffith, J (reprint author), USA, Natl Guard Bur, Soldier & Family Support Div, Arlington, VA USA. EM james.e.griffith@us.army.mil NR 64 TC 11 Z9 12 U1 2 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1094-3412 J9 J BEHAV HEALTH SER R JI J. Behav. Health Serv. Res. PD APR PY 2013 VL 40 IS 2 BP 140 EP 155 DI 10.1007/s11414-013-9320-8 PG 16 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 138ON UT WOS:000318518100002 PM 23494766 ER PT J AU Zhong, XL Mukhopadhyay, S Gowtham, S Pandey, R Karna, SP AF Zhong, Xiaoliang Mukhopadhyay, Saikat Gowtham, S. Pandey, Ravindra Karna, Shashi P. TI Applicability of carbon and boron nitride nanotubes as biosensors: Effect of biomolecular adsorption on the transport properties of carbon and boron nitride nanotubes SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRONIC TRANSPORT; DNA; HYBRIDIZATION; TRANSISTORS; FUNCTIONALIZATION; ORIENTATION; SIMULATION; MOLECULES AB The effect of molecular adsorption on the transport properties of single walled carbon and boron nitride nanotubes (CNTs and BNNTs) is investigated using density functional theory and non-equilibrium Green's function methods. The calculated I-V characteristics predict noticeable changes in the conductivity of semiconducting BNNTs due to physisorption of nucleic acid base molecules. Specifically, guanine which binds to the side wall of BNNT significantly enhances its conductivity by introducing conduction channels near the Fermi energy of the bioconjugated system. For metallic CNTs, a large background current masks relatively small changes in current due to the biomolecular adsorption. The results therefore suggest the suitability of BNNTs for biosensing applications. (C) 2013 AIP Publishing LLC. [http://dx.doi.org/10.1063/1.4801442] C1 [Zhong, Xiaoliang; Mukhopadhyay, Saikat; Gowtham, S.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Mukhopadhyay, Saikat/B-4402-2011; Zhong, Xiaoliang/B-2220-2012 FU Army Research Office [W911NF-09-1-0221] FX Helpful discussions with Haiying He are acknowledged. The work at Michigan Technological University was performed under support by the Army Research Office through Contract No. W911NF-09-1-0221. NR 39 TC 3 Z9 3 U1 1 U2 34 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 1 PY 2013 VL 102 IS 13 AR 133705 DI 10.1063/1.4801442 PG 4 WC Physics, Applied SC Physics GA 121JT UT WOS:000317240200089 ER PT J AU Lu, XCM Mountney, A Chen, ZY Wei, G Cao, Y Leung, LY Khatri, V Cunningham, T Tortella, FC AF Lu, Xi-Chun May Mountney, Andrea Chen, Zhiyong Wei, Guo Cao, Ying Leung, Lai Yee Khatri, Vivek Cunningham, Tracy Tortella, Frank C. TI Similarities and Differences of Acute Nonconvulsive Seizures and Other Epileptic Activities following Penetrating and Ischemic Brain Injuries in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE EEG rat; MCAO; NCS; PBBI ID INTENSIVE-CARE-UNIT; FOCAL CEREBRAL-ISCHEMIA; PERIODIC EEG PATTERNS; TRANSHEMISPHERIC DIASCHISIS; CLINICAL-SIGNIFICANCE; GLYPROMATE ANALOG; CRITICALLY-ILL; DISCHARGES; MODEL; STROKE AB The similarities and differences between acute nonconvulsive seizures (NCS) and other epileptic events, for example, periodic epileptiform discharges (PED) and intermittent rhythmic delta activities (IRDA), were characterized in rat models of penetrating and ischemic brain injuries. The NCS were spontaneously induced by either unilateral frontal penetrating ballistic-like brain injury (PBBI) or permanent middle cerebral artery occlusion (pMCAO), and were detected by continuous electroencephalogram (EEG) monitoring begun immediately after the injury and continued for 72 h or 24 h, respectively. Analysis of NCS profiles (incidence, frequency, duration, and time distribution) revealed a high NCS incidence in both injury models. The EEG waveform expressions of NCS and PED exhibited intrinsic variations that resembled human electrographic manifestations of post-traumatic and post-ischemic ictal and inter-ictal events, but these waveform variations were not distinguishable between the two types of brain injury. However, the NCS after pMCAO occurred more acutely and intensely (latency = 0.6 h, frequency = 25 episodes/rat) compared with the PBBI-induced NCS (latency = 24 h, frequency = 10 episodes/rat), such that the most salient features differentiating post-traumatic and post-ischemic NCS were the intensity and time distribution of the NCS profiles. After pMCAO, nearly 50% of the seizures occurred within the first 2 h of injury, whereas after PBBI, NCS occurred sporadically (0-5%/h) throughout the 72 h recording period. The PED were episodically associated with NCS. By contrast, the IRDA appeared to be independent of other epileptic events. This study provided comprehensive comparisons of post-traumatic and post-ischemic epileptic profiles. The identification of the similarities and differences across a broad spectrum of epileptic events may lead to differential strategies for post-traumatic and post-stroke seizure interventions. C1 [Lu, Xi-Chun May; Mountney, Andrea; Chen, Zhiyong; Wei, Guo; Cao, Ying; Leung, Lai Yee; Khatri, Vivek; Cunningham, Tracy; Tortella, Frank C.] Walter Reed Army Inst Res, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM may.lu@us.army.mil RI Leung, Lai Yee/H-8204-2013 NR 43 TC 10 Z9 10 U1 0 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD APR PY 2013 VL 30 IS 7 BP 580 EP 590 DI 10.1089/neu.2012.2641 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 133PD UT WOS:000318150300009 PM 23234254 ER PT J AU Chalermchai, T Valcour, V Sithinamsuwan, P Pinyakorn, S Clifford, D Paul, RH Tipsuk, S Fletcher, JLK DeGruttola, V Ratto-Kim, S Hutchings, N Shikuma, C Ananworanich, J AF Chalermchai, Thep Valcour, Victor Sithinamsuwan, Pasiri Pinyakorn, Suteeraporn Clifford, David Paul, Robert H. Tipsuk, Somporn Fletcher, James L. K. DeGruttola, Victor Ratto-Kim, Silvia Hutchings, Nicholas Shikuma, Cecilia Ananworanich, Jintanat CA SEARCH 007 Study Grp SEARCH 011 Study Grp TI Trail Making Test A improves performance characteristics of the International HIV Dementia Scale to identify symptomatic HAND SO JOURNAL OF NEUROVIROLOGY LA English DT Article DE HIV dementia; Neuropsychology; Asia; Neuropsychological tests; Trail Making Test ID RAPID SCREENING-TEST; NEUROCOGNITIVE DISORDERS; ANTIRETROVIRAL THERAPY; INFECTED ADULTS; IMPAIRMENT; POPULATION; DISEASE; AIDS AB Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand for the identification of symptomatic HAND, defined as both HAD and mild neurocognitive disorder. We then sought to determine if adding a simple test from a larger neuropsychological battery could improve the performance characteristics for identifying symptomatic HAND. In this study, subjects comprising 75 seropositive adults in Bangkok, Thailand, completed neuropsychological tests and underwent a full neurological assessment. HAND diagnoses were determined by consensus conference using the 2007 Frascati criteria, blinded to the IHDS results. The optimal IHDS cut point was determined by receiver operating characteristic analysis with cross-validation. Individual neuropsychological tests were then evaluated and combined with the IHDS to test performance characteristics. The IHDS was poor at detecting symptomatic HAND at the optimized cut point of a parts per thousand currency sign10 (sensitivity, 53.3 %; specificity, 89.8 %). Trail Making Test A was most effective in improving performance characteristics when combined with the IHDS, with net sensitivity of 86 % and specificity of 79 %. In this setting, the IHDS performed poorly in identifying symptomatic HAND, but was substantially improved by the addition of Trail Making Test A, which typically requires less than 2 min to complete. This combination should be validated in a larger setting since it may address the critical need for HAND screening instruments in international settings. C1 [Chalermchai, Thep; Tipsuk, Somporn; Fletcher, James L. K.; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Valcour, Victor; Hutchings, Nicholas] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA. [Valcour, Victor] Univ Calif San Francisco, Dept Med, Div Geriatr Med, San Francisco, CA 94158 USA. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Bangkok, Thailand. [Pinyakorn, Suteeraporn; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. [Clifford, David] Washington Univ, Dept Neurol, St Louis, MO USA. [Paul, Robert H.] Univ Missouri, Dept Psychol, St Louis, MO 63121 USA. [DeGruttola, Victor] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Ratto-Kim, Silvia] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Shikuma, Cecilia] Univ Hawaii Manoa, Hawaii Ctr AIDS, Honolulu, HI 96822 USA. RP Valcour, V (reprint author), Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, 675 Nelson Rising Lane,MC 1207, San Francisco, CA 94158 USA. EM vvalcour@memory.ucsf.edu FU NIH [R01-NS053359, R01-NS061696] FX This work was supported by NIH grants R01-NS053359 (SR) and R01-NS061696 (VV). We thank the study subjects for their participation and Nicholas Hutchings for assistance with the manuscript. NR 46 TC 8 Z9 8 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1355-0284 EI 1538-2443 J9 J NEUROVIROL JI J. Neurovirol. PD APR PY 2013 VL 19 IS 2 BP 137 EP 143 DI 10.1007/s13365-013-0151-4 PG 7 WC Neurosciences; Virology SC Neurosciences & Neurology; Virology GA 138NJ UT WOS:000318515000005 PM 23483520 ER PT J AU Zubko, E Muinonen, K Shkuratov, Y Videen, G AF Zubko, Evgenij Muinonen, Karri Shkuratov, Yuriy Videen, Gorden TI Characteristics of cometary dust in the innermost coma derived from polarimetry by Giotto SO MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY LA English DT Article DE comets: individual: 1P/Halley; comets: individual: 26P/Grigg-Skjellerup; comets: individual: 81P/Wild 2 ID DISCRETE-DIPOLE APPROXIMATION; GAUSSIAN RANDOM PARTICLES; LIGHT-SCATTERING; OPTICAL-CONSTANTS; GRIGG-SKJELLERUP; 81P/WILD-2 DUST; HALLEY DUST; POLARIZATION; SIMULATIONS; SPACECRAFT AB We interpret the polarimetric measurements of Comets 1P/Halley and 26P/Grigg-Skjellerup carried out by the Giotto space probe using light-scattering properties of model agglomerate particles having different structures and compositions. Our simulations suggest that the overall low linear polarization registered in the innermost coma can be interpreted in terms of a high abundance of Mg-rich silicate particles and depletion of carbonaceous materials. Variation of the polarization throughout the innermost coma could be explained either through a significant variation in the size distribution or through a slight variation of refractive index of cometary dust, whereas even a considerable difference in the morphology of agglomerate particles has a weak impact on the linear polarization. C1 [Zubko, Evgenij; Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. RP Zubko, E (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland. EM Evgenij.Zubko@helsinki.fi FU Academy of Finland [127461]; NASA program for Outer Planets Research [NNX10AP93G] FX This work was partially supported by the Academy of Finland (contract 127461) and by NASA program for Outer Planets Research (grant NNX10AP93G). We are grateful to Prof. A. Ch. Levasseur-Regourd for valuable comments on this paper. NR 35 TC 8 Z9 8 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-8711 J9 MON NOT R ASTRON SOC JI Mon. Not. Roy. Astron. Soc. PD APR PY 2013 VL 430 IS 2 BP 1118 EP 1124 DI 10.1093/mnras/sts679 PG 7 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 135FY UT WOS:000318275000030 ER PT J AU Seay, JF Ely, BR Kenefick, RW Sauer, SG Cheuvront, SN AF Seay, Joseph F. Ely, Brett R. Kenefick, Robert W. Sauer, Shane G. Cheuvront, Samuel N. TI Hypohydration Does Not Alter Standing Balance SO MOTOR CONTROL LA English DT Article DE dehydration; center of pressure; sway path; sway velocity; plasma volume; plasma osmolality ID POSTURAL STABILITY; HEAT-STRESS; COLD-AIR; DEHYDRATION; EXERCISE; PERFORMANCE; BLOOD; RESPONSES; FATIGUE; HYDRATION AB We examined the effect of body water deficits on standing balance and sought to determine if plasma hyperosmolality (P-osm) and/or volume reduction (%Delta V-plasma) exerted independent effects. Nine healthy volunteers completed three experimental trials which consisted of a euhydration (EUH) balance test, a water deficit session and a hypohydration (HYP) balance test. Hypohydration was achieved both by exercise-heat stress to 3% and 5% body mass loss (BML), and by a diuretic to 3% BML. Standing balance was assessed during quiet standing on a force platform with eyes open and closed. With eyes closed, hypohydration significantly decreased medial-lateral sway path and velocity by 13% (both p < .040). However, 95% confidence intervals for the mean difference between EUH and HYP were all within the coefficient of variation of EUH measures, indicating limited practical importance. Neither V-plasma loss nor P-osm increases were associated with changes in balance. We concluded that standing balance was not altered by hypohydration. C1 [Seay, Joseph F.; Ely, Brett R.; Kenefick, Robert W.; Sauer, Shane G.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Seay, JF (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 40 TC 2 Z9 2 U1 0 U2 6 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1087-1640 J9 MOTOR CONTROL JI Motor Control PD APR PY 2013 VL 17 IS 2 BP 190 EP 202 PG 13 WC Neurosciences; Sport Sciences SC Neurosciences & Neurology; Sport Sciences GA 139KE UT WOS:000318580800005 PM 23155117 ER PT J AU Hong, SS Yheulon, CG Sniezek, JC AF Hong, Steven S. Yheulon, Christopher G. Sniezek, Joseph C. TI Salivary Gland Surgery and Medical Malpractice SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT AAO-HNSF Annual Meeting and OTO EXPO CY SEP 09-12, 2012 CL Washington, DC SP AAO, HNSF, Off Res & Dev, Vet Hlth Adm, Dept Vet Affairs, MED-EL, Agcy Healthcare Res & Qual, Sect Residents & Fellows Training DE salivary gland; parotid gland; submandibular gland; malpractice; legal; lawsuit; facial nerve monitor; facial nerve; lingual nerve; informed consent ID FACIAL-NERVE SCHWANNOMA; PARALYSIS; PAROTIDECTOMY; EXPERIENCE; MANAGEMENT AB Objective. To better understand the causes and outcomes of lawsuits involving salivary gland surgery by analyzing malpractice litigation trends to prevent future litigation and improve physician education. Study Design. Analysis of a national database. Setting. All US civil trials. Subjects and Methods. The WESTLAW database was reviewed from January 1987 to March 2011. Data were compiled on the demographics of the defendant, anatomic site of injury, initial pathology, nature of injury, legal allegations, verdicts, and indemnities. Results. Twenty-six cases met inclusion criteria and were selected for review. Verdicts/settlements for the plaintiffs predominated (58%), and the average sum of the plaintiff's monetary award was $933,235. Sixteen cases (62%) involved injury to the parotid gland/duct, with 10 cases involving injury to the facial nerve. No cases were filed on the grounds of failure to use facial nerve monitoring. Nine cases (35%) involved injury to the submandibular gland/duct. The most common legal allegations listed were improper performance followed by unnecessary procedures. If failure or inadequate consent was a component of the legal allegations, the verdict outcome significantly favored the defendants. Conclusion. Our study reveals that the plaintiffs in litigations involving salivary gland surgery have a slight advantage in outcomes with a fairly substantial award. Our litigation review reiterates the importance of detailed anatomic knowledge of the lingual and facial nerve to avoid the pitfalls of surgical error and consequent litigation. In addition, thorough preoperative evaluation of salivary gland pathology, including radiographic studies and needle biopsy, may help avoid errors in diagnosis and subsequent litigations. C1 [Hong, Steven S.; Yheulon, Christopher G.; Sniezek, Joseph C.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Hong, SS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM shongmd@gmail.com NR 23 TC 17 Z9 17 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2013 VL 148 IS 4 BP 589 EP 594 DI 10.1177/0194599813475566 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 136LG UT WOS:000318362800011 PM 23380759 ER PT J AU Liu, YH Xu, YH Zhu, YJ Culver, JN Lundgren, CA Xu, K Wang, CS AF Liu, Yihang Xu, Yunhua Zhu, Yujie Culver, James N. Lundgren, Cynthia A. Xu, Kang Wang, Chunsheng TI Tin-Coated Viral Nanoforests as Sodium-Ion Battery Anodes SO ACS NANO LA English DT Article DE Na-ion batteries; Sn nanoforest anodes; nanohierarchy; tobacco mosaic virus; physical vapor deposition; magnetron sputtering ID LITHIUM SECONDARY BATTERIES; RECHARGEABLE NA BATTERIES; HIGH-CAPACITY; ELECTRODE MATERIAL; HOLLOW CARBON; ELECTROCHEMICAL PROPERTIES; THIN-FILM; SN; INSERTION; PERFORMANCE AB Designed as a high-capacity alloy host for Na-ion chemistry, a forest of 5n nanorods with a unique core-shell structure was synthesized on viral scaffolds, which were genetically engineered to ensure a nearly vertical alignment upon self-assembly onto a metal substrate. The interdigital spaces thus formed between individual rods effectively accommodated the volume expansion and contraction of the alloy upon sodiation/desodiation, while additional carbon-coating engineered over these nanorods further suppressed Sn aggregation during extended electrochemical cycling. Due to the unique nanohierarchy of multiple functional layers, the resultant 3D nanoforest of C/Sn/Ni/TMV1cys, binder-free composite electrode already and evenly assembled on a stainless steel current collector, exhibited supreme capacity utilization and cycling stability toward Na-ion storage and release. An initial capacity of 722 mA.h (g Sn)(-1) along with 405 mA.h (g Sn)(-1) retained after 150 deep cycles demonstrates the longest-cycling nano-Sn anode material for Na-ion batteries reported in the literature to date and marks a significant performance improvement for neat Sn material as alloy host for Na-ion chemistry. C1 [Liu, Yihang; Xu, Yunhua; Zhu, Yujie; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Culver, James N.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. [Culver, James N.] Univ Maryland, Dept Plant Sci & Landscape Architecture, College Pk, MD 20742 USA. [Lundgren, Cynthia A.; Xu, Kang] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil; cswang@umd.edu RI Wang, Chunsheng/H-5767-2011; Xu, Yunhua/D-7751-2012; Liu, Yihang/E-6958-2013 OI Wang, Chunsheng/0000-0002-8626-6381; Liu, Yihang/0000-0002-2491-9439 FU U.S. Army Research Laboratory; Nanostructures for Electrical Energy Storage, an Energy Frontier Research Center; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DESC0001160] FX The authors acknowledge financial support from the U.S. Army Research Laboratory and the technical support of the Maryland NanoCenter. We thank Dr. Li-Chung Lai for the TEM imaging, John Abrahams for the deposition, and Yanmei Piao for collecting the Raman data. Y. Liu was partially supported as part of the Nanostructures for Electrical Energy Storage, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DESC0001160. NR 54 TC 124 Z9 127 U1 41 U2 434 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD APR PY 2013 VL 7 IS 4 BP 3627 EP 3634 DI 10.1021/nn400601y PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 133MU UT WOS:000318143300079 PM 23484633 ER PT J AU Margolis, LM Rood, J Champagne, C Young, AJ Castellani, JW AF Margolis, Lee M. Rood, Jennifer Champagne, Catherine Young, Andrew J. Castellani, John W. TI Energy balance and body composition during US Army special forces training SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article DE doubly labeled water; energy expenditure; energy intake; military training ID SUSTAINED EXERCISE; PHYSICAL-ACTIVITY; WATER MEASUREMENT; LABELED WATER; FOOD-INTAKE; EXPENDITURE; MEN; PERFORMANCE; SOLDIERS; HUMANS AB Small Unit Tactics (SUT) is a 64-day phase of the Special Forces Qualification Course designed to simulate real-world combat operations. Assessing the metabolic and physiological responses of such intense training allows greater insights into nutritional requirements of soldiers during combat. The purpose of this study was to examine energy balance around specific training events, as well as changes in body mass and composition. Data were collected from 4 groups of soldiers (n = 36) across 10-day periods. Participants were 28 +/- 5 years old, 177 +/- 6 cm tall, and weighed 83 +/- 7 kg. Doubly labeled water ((D2O)-O-18) was used to assess energy expenditure. Energy intake was calculated by subtracting energy in uneaten foods from known energy in distributed foods in individually packaged combat rations or in the dining facility. Body composition was estimated from skinfold thickness measurements on days 0 and 64 of the course. Simulated urban combat elicited that largest energy deficit (11.3 +/- 2.3 MJ.day(-1) (2700 +/- 550 kcal.day(-1)); p < 0.05), and reduction in body mass (3.3 +/- 1.9 kg; p < 0.05), during SUT, while energy balance was maintained during weapons familiarization training and platoon size raids. Over the entire course body mass decreased by 4.2 +/- 3.7 kg (p < 0.01), with fat mass decreasing by 2.8 +/- 2.0 kg (p < 0.01) and fat-free mass decreasing by 1.4 +/- 2.8 kg (p < 0.05). The overall reduction in body mass suggests that soldiers were in a negative energy balance during SUT, with high energy deficit being observed during strenuous field training. C1 [Margolis, Lee M.; Young, Andrew J.; Castellani, John W.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer; Champagne, Catherine] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. RP Margolis, LM (reprint author), USA, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM lee.margolis@us.army.mil OI , Lee/0000-0002-0652-1304 NR 33 TC 5 Z9 5 U1 0 U2 14 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 1715-5312 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD APR PY 2013 VL 38 IS 4 BP 396 EP 400 DI 10.1139/apnm-2012-0323 PG 5 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA 131AA UT WOS:000317961300006 PM 23713532 ER PT J AU Webber, AF Heath, JA Fischer, RA AF Webber, Alyson F. Heath, Julie A. Fischer, Richard A. TI Human disturbance and stage-specific habitat requirements influence snowy plover site occupancy during the breeding season SO ECOLOGY AND EVOLUTION LA English DT Article DE Beach; coastal engineering; multi-season occupancy models; nesting; restoration; shorebird ID CHARADRIUS-ALEXANDRINUS; THINORNIS-RUBRICOLLIS; REPRODUCTIVE SUCCESS; FLEDGING SUCCESS; PIPING PLOVERS; NEST SUCCESS; NEW-YORK; SELECTION; PREDATION; RESPONSES AB Habitat use has important consequences for avian reproductive success and survival. In coastal areas with recreational activity, human disturbance may limit use of otherwise suitable habitat. Snowy plovers Charadrius nivosus have a patchy breeding distribution along the coastal areas on the Florida Panhandle, USA. Our goal was to determine the relative effects of seasonal human disturbance and habitat requirements on snowy plover habitat use. We surveyed 303 sites for snowy plovers, human disturbance, and habitat features between January and July 2009 and 2010. We made multiple visits during three different sampling periods that corresponded to snowy plover breeding: pre-breeding, incubation, and brood-rearing and used multi-season occupancy models to examine whether human disturbance, habitat features, or both influenced site occupancy, colonization (probability of transition from an unoccupied site to an occupied site), and extinction (probability of transition from an occupied site to an unoccupied site). Snowy plover site occupancy and colonization was negatively associated with human disturbance and site extinction was positively associated with human disturbance. Interdune vegetation had a negative effect on occupancy and colonization, indicating that plovers were less likely to use areas with uniform, dense vegetation among dunes. Also, dune shape, beach debris, and access to low-energy foraging areas influenced site occupancy, colonization, and extinction. Plovers used habitat based on beach characteristics that provided stage-specific resource needs; however, human disturbance was the strongest predictor of site occupancy. In addition, vegetation plantings used to enhance dune rehabilitation may negatively impact plover site occupancy. Management actions that decrease human disturbance, such as symbolic fencing and signage, may increase the amount of breeding habitat available to snowy plovers on the Florida Panhandle and in other areas with high human activity. The specific areas that require this protection may vary across snowy plover life history stages. C1 [Webber, Alyson F.; Heath, Julie A.] Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA. [Fischer, Richard A.] USACE Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Webber, AF (reprint author), Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA. EM afwebber@gmail.com RI Heath, Julie/D-5600-2011 OI Heath, Julie/0000-0002-9606-1689 FU U.S. Army Engineer Research and Development Center Boise State University; U.S. Army Engineer Research and Development Center, Dredging Operations and Environmental Research Program FX U.S. Army Engineer Research and Development Center Boise State University; We thank C. Lott, I. Robertson, and R. Pruner for advice in designing this project. D. Bateman and M. Foster helped with data collection. We thank: J. Bente, J. Zimmerman, A. Harvey, M. Cory-Ogden, T. Tindall, M. Knapke, D. Schingler, and C. Keen with Florida State Parks, R. Hoggart and M. Nicholas at Gulf Islands National Seashore, B. Miller and K. Gault at Eglin Air Force Base, W. Jones at Tyndall Air Force Base, P. Kelly and H. Mitchell at USFWS, J. Himes at Florida Fish and Wildlife Conservation Commission. M. Currie of Walton County, T. Day of Escambia County, and S. Smith of the Santa Rosa Island Authority for logistical and permitting support. Thanks also to all the private land owners who granted access for this study. This project was funded by U.S. Army Engineer Research and Development Center, Dredging Operations and Environmental Research Program. NR 59 TC 14 Z9 15 U1 4 U2 61 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD APR PY 2013 VL 3 IS 4 BP 853 EP 863 DI 10.1002/ece3.511 PG 11 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA 126FW UT WOS:000317599300010 PM 23610630 ER PT J AU Palacios, G Savji, N da Rosa, AT Desai, A Sanchez-Seco, MP Guzman, H Lipkin, WI Tesh, R AF Palacios, Gustavo Savji, Nazir da Rosa, Amelia Travassos Desai, Aaloki Paz Sanchez-Seco, Maria Guzman, Hilda Lipkin, W. Ian Tesh, Robert TI Characterization of the Salehabad virus species complex of the genus Phlebovirus (Bunyaviridae) SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID VALLEY FEVER VIRUS; HIDDEN MARKOV MODEL; COMPLETE GENOMES; GOLGI RETENTION; TOSCANA-VIRUS; PROTEIN; PREDICTION; TOPOLOGY; SEQUENCE; SOFTWARE AB Genomic and antigenic characterization of the Salehabad virus, a species of the genus Phlebovirus, and four other unclassified phleboviruses (Arbia, Adria, Arumowot and Odrenisrou) demonstrate a serological and genetic relation to one another and are distinct from the, eight other recognized species within the genus Phlebovirus. We propose to incorporate these four unclassified viruses as part of the Salehabad species complex within the genus. The known geographical distribution for the members of this species group includes southern Europe, Central Asia and Africa. C1 [Palacios, Gustavo] USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD 21702 USA. [Palacios, Gustavo; Savji, Nazir; Desai, Aaloki; Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [da Rosa, Amelia Travassos; Guzman, Hilda; Tesh, Robert] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. [Paz Sanchez-Seco, Maria] Inst Salud Carlos III, Natl Ctr Microbiol, Madrid, Spain. RP Palacios, G (reprint author), USA, Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@us.army.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU National Institutes of Health [AI57158]; USAID [07-301-7119-52258]; Department of Defense; NIH [HHSN2722010000ROI/HHSN27200004/DO4] FX This work was supported by Google.org, National Institutes of Health award AI57158 (North-east Biodefence Center - Lipkin), and USAID Predict funding source code 07-301-7119-52258 (Center for Infection and Immunity) and the Department of Defense. A. T. R., R. T. and H. G. were supported by NIH contract HHSN2722010000ROI/HHSN27200004/DO4. NR 36 TC 12 Z9 12 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD APR PY 2013 VL 94 BP 837 EP 842 DI 10.1099/vir.0.048850-0 PN 4 PG 6 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 131LM UT WOS:000317995200017 PM 23239568 ER PT J AU Kontos, AP Kotwal, RS Elbin, RJ Lutz, RH Forsten, RD Benson, PJ Guskiewicz, KM AF Kontos, Anthony P. Kotwal, Russ S. Elbin, R. J. Lutz, Robert H. Forsten, Robert D. Benson, Peter J. Guskiewicz, Kevin M. TI Residual Effects of Combat-Related Mild Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE mTBI; PTSD; symptoms; military ID PROFESSIONAL FOOTBALL PLAYERS; OPERATION-IRAQI-FREEDOM; MENTAL-HEALTH PROBLEMS; RECURRENT CONCUSSION; HISTORY; AFGHANISTAN; COLLEGIATE; SERVICE; RISK; CARE AB Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of the study was to compare residual mTBI and PTSD symptoms, and neurocognitive deficits among U.S. Army Special Operations Command (USASOC) personnel with diagnosed blunt, blast, and blast-blunt combination mTBIs. This study involved a retrospective medical records review of 27,169 USASOC personnel who completed a military version of the Immediate Post-Concussion Assessment Cognitive Test (ImPACT), Post-Concussion Symptom Scale (PCSS), and PTSD Checklist (PCL) between November 2009 and December 2011. Of the 22,203 personnel who met criteria for the study, 2,813 (12.7%) had a diagnosis of at least one mTBI. A total of 28% (n = 410) of USASOC personnel with a history of diagnosed mTBI reported clinical levels of PTSD symptoms. Personnel with a history of diagnosed blunt (OR = 3.58), blast (OR = 4.23) or combination (OR = 5.73) mTBI were at significantly (p = 0.001) greater risk of reporting clinical levels of PTSD symptoms than those with no history of mTBI. A dose-response gradient for exposure to blast/combination mTBI on clinical levels of PTSD symptoms was also significant (p = 0.001). Individuals with blast/combination mTBIs scored higher in residual mTBI (p = 0.001) and PTSD symptoms (p = 0.001), and performed worse on tests of visual memory (p = 0.001), and reaction time (p = 0.001) than those with blunt or no mTBI history. Individuals with combination mTBIs scored lower in verbal memory (p = 0.02) than those with blunt mTBIs. Residual PTSD and mTBI symptoms appear to be more prevalent in personnel with blast mTBI. A dose-response gradient for blast mTBI and symptoms suggests that repeated exposures to these injuries may have lingering effects. C1 [Kontos, Anthony P.; Elbin, R. J.] Univ Pittsburgh, Med Ctr, Sports Med Concuss Program, Pittsburgh, PA 15203 USA. [Kotwal, Russ S.; Lutz, Robert H.; Forsten, Robert D.; Benson, Peter J.] USA, Special Operat Command, Ft Bragg, NC USA. [Guskiewicz, Kevin M.] Univ N Carolina, Matthew Gfeller Sport Related Traumat Brain Injur, Chapel Hill, NC USA. RP Kontos, AP (reprint author), Univ Pittsburgh, Sch Med, Dept Orthopaed Surg, UPMC Sports Med Concuss Program, 3200 South Water St, Pittsburgh, PA 15203 USA. EM akontos@pitt.edu OI Guskiewicz, Kevin/0000-0002-8682-2130 FU U.S. Special Operations Command Biomedical Initiatives Steering Committee FX This research was funded by the U.S. Special Operations Command Biomedical Initiatives Steering Committee. The views expressed herein are those of the author(s) and do not reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government. Citations of commercial products or organizations do not constitute an official DoD endorsement or approval of the products or services of these organizations. This report was approved for public release by the U.S. Army Special Operations Command Operational Security Office and Public Affairs Office on March 27, 2012, and the U.S. Army Medical Department Public Affairs Office on March 27, 2012. NR 31 TC 29 Z9 30 U1 1 U2 27 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD APR PY 2013 VL 30 IS 8 SI SI BP 680 EP 686 DI 10.1089/neu.2012.2506 PG 7 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 133PO UT WOS:000318151500010 PM 23031200 ER PT J AU Grant, KW Walden, BE Summers, V Leek, MR AF Grant, Ken W. Walden, Brian E. Summers, Van Leek, Marjorie R. TI Auditory Models of Suprathreshold Distortion in Persons with Impaired Hearing Introduction SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Editorial Material ID SPEECH-RECEPTION THRESHOLD; NOISE; AID; LISTENERS; COGNITION; BENEFIT C1 [Grant, Ken W.; Summers, Van] Walter Reed Natl Mil Med Ctr, Sci & Clin Studies Sect, Audiol & Speech Ctr, Bethesda, MD USA. [Walden, Brian E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Leek, Marjorie R.] Portland VA Med Ctr, VA RR&D Natl Ctr Rehabil Auditory Res, Portland, OR USA. RP Grant, KW (reprint author), Walter Reed Natl Mil Med Ctr, Sci & Clin Studies Sect, Audiol & Speech Ctr, Bethesda, MD USA. NR 24 TC 3 Z9 3 U1 0 U2 2 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD APR PY 2013 VL 24 IS 4 BP 254 EP 257 DI 10.3766/jaaa.24.4.2 PG 4 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 134JK UT WOS:000318206300002 PM 23636207 ER PT J AU Malhotra, S Yen, JY Honko, AN Garamszegi, S Caballero, IS Johnson, JC Mucker, EM Trefry, JC Hensley, LE Connor, JH AF Malhotra, Shikha Yen, Judy Y. Honko, Anna N. Garamszegi, Sara Caballero, Ignacio S. Johnson, Joshua C. Mucker, Eric M. Trefry, John C. Hensley, Lisa E. Connor, John H. TI Transcriptional Profiling of the Circulating Immune Response to Lassa Virus in an Aerosol Model of Exposure SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID EBOLA HEMORRHAGIC-FEVER; CD8 T-CELLS; MASTOMYS-NATALENSIS; CYNOMOLGUS MONKEYS; DENDRITIC CELLS; GUINEA-PIGS; NONHUMAN-PRIMATES; GENE-EXPRESSION; SIERRA-LEONE; INFECTION AB Lassa virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with LASV leads to the development of hemorrhagic fever in a significant number of cases, and it is estimated that thousands die each year from the disease. Little is known about the complex immune mechanisms governing the response to LASV or the genetic determinants of susceptibility and resistance to infection. In the study presented here, we have used a whole-genome, microarray-based approach to determine the temporal host response in the peripheral blood mononuclear cells (PBMCs) of non-human primates (NHP) following aerosol exposure to LASV. Sequential sampling over the entire disease course showed that there are strong transcriptional changes of the immune response to LASV exposure, including the early induction of interferon-responsive genes and Toll-like receptor signaling pathways. However, this increase in early innate responses was coupled with a lack of pro-inflammatory cytokine response in LASV exposed NHPs. There was a distinct lack of cytokines such as IL1 beta and IL23 alpha, while immunosuppressive cytokines such as IL27 and IL6 were upregulated. Comparison of IRF/STAT1-stimulated gene expression with the viral load in LASV exposed NHPs suggests that mRNA expression significantly precedes viremia, and thus might be used for early diagnostics of the disease. Our results provide a transcriptomic survey of the circulating immune response to hemorrhagic LASV exposure and provide a foundation for biomarker identification to allow clinical diagnosis of LASV infection through analysis of the host response. C1 [Malhotra, Shikha; Yen, Judy Y.; Garamszegi, Sara; Caballero, Ignacio S.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Honko, Anna N.; Johnson, Joshua C.; Mucker, Eric M.; Trefry, John C.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Garamszegi, Sara; Caballero, Ignacio S.; Connor, John H.] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA. [Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD USA. RP Malhotra, S (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Johnson, Joshua/0000-0002-5677-3841; Connor, John/0000-0002-8867-7256; Honko, Anna/0000-0001-9165-148X FU Joint Science and Technology Office for Chemical and Biological Defense; Defense Threat Reduction Agency [JSTO-CBD 4.0021.08.RD.B]; NSF Graduate Research Fellowships Program; Fulbright Commission Spain; Regional Government of Andalusia FX This research was supported by a grant through the Joint Science and Technology Office for Chemical and Biological Defense and the Defense Threat Reduction Agency (JSTO-CBD 4.0021.08.RD.B). SG was supported by the NSF Graduate Research Fellowships Program. ISC was supported by the Fulbright Commission Spain and the Regional Government of Andalusia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 12 Z9 12 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2013 VL 7 IS 4 AR e2171 DI 10.1371/journal.pntd.0002171 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 133QC UT WOS:000318153100025 PM 23638192 ER PT J AU Reed, C Lin, K Wilhelmsen, C Friedrich, B Nalca, A Keeney, A Donnelly, G Shamblin, J Hensley, LE Olinger, G Smith, DR AF Reed, Christopher Lin, Kenny Wilhelmsen, Catherine Friedrich, Brian Nalca, Aysegul Keeney, Ashley Donnelly, Ginger Shamblin, Joshua Hensley, Lisa E. Olinger, Gene Smith, Darci R. TI Aerosol Exposure to Rift Valley Fever Virus Causes Earlier and More Severe Neuropathology in the Murine Model, which Has Important Implications for Therapeutic Development SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID NORTH-AMERICAN MOSQUITOS; INFECTION; RIBAVIRIN; MICE; PATHOGENESIS; EPIDEMIC; DISEASE; AFRICA; EGYPT AB Rift Valley fever virus (RVFV) is an important mosquito-borne veterinary and human pathogen that can cause severe disease including acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome. Currently, no licensed vaccine or therapeutics exist to treat this potentially deadly disease. Detailed studies describing the pathogenesis of RVFV following aerosol exposure have not been completed and candidate therapeutics have not been evaluated following an aerosol exposure. These studies are important because while mosquito transmission is the primary means for human infection, it can also be transmitted by aerosol or through mucosal contact. Therefore, we directly compared the pathogenesis of RVFV following aerosol exposure to a subcutaneous (SC) exposure in the murine model by analyzing survival, clinical observations, blood chemistry, hematology, immunohistochemistry, and virus titration of tissues. Additionally, we evaluated the effectiveness of the nucleoside analog ribavirin administered prophylactically to treat mice exposed by aerosol and SC. The route of exposure did not significantly affect the survival, chemistry or hematology results of the mice. Acute hepatitis occurred despite the route of exposure. However, the development of neuropathology occurred much earlier and was more severe in mice exposed by aerosol compared to SC exposed mice. Mice treated with ribavirin and exposed SC were partially protected, whereas treated mice exposed by aerosol were not protected. Early and aggressive viral invasion of brain tissues following aerosol exposure likely played an important role in ribavirin's failure to prevent mortality among these animals. Our results highlight the need for more candidate antivirals to treat RVFV infection, especially in the case of a potential aerosol exposure. Additionally, our study provides an account of the key pathogenetic differences in RVF disease following two potential exposure routes and provides important insights into the development and evaluation of potential vaccines and therapeutics to treat RVFV infection. C1 [Reed, Christopher; Lin, Kenny; Wilhelmsen, Catherine; Friedrich, Brian; Nalca, Aysegul; Keeney, Ashley; Donnelly, Ginger; Shamblin, Joshua; Hensley, Lisa E.; Olinger, Gene; Smith, Darci R.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Reed, C (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM darci.smith@colostate.edu RI sebastianovitsch, stepan/G-8507-2013; OI Olinger, Gene/0000-0001-7338-0292 FU Transformational Medical Technologies program from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency [TMT.DRUG.01.10.RD.002] FX This work was supported by the Transformational Medical Technologies program from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (Project No. TMT.DRUG.01.10.RD.002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 19 Z9 19 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2013 VL 7 IS 4 AR e2156 DI 10.1371/journal.pntd.0002156 PG 15 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 133QC UT WOS:000318153100017 PM 23593523 ER PT J AU Klapotke, TM Piercey, DG Mehta, N Oyler, KD Jorgensen, M Lenahan, S Salan, JS Fronabarger, JW Williams, MD AF Klapoetke, Thomas M. Piercey, Davin G. Mehta, Neha Oyler, Karl D. Jorgensen, Matthew Lenahan, Shannon Salan, Jerry S. Fronabarger, John W. Williams, Michael D. TI Preparation of High Purity Sodium 5-Nitrotetrazolate (NaNT): An Essential Precursor to the Environmentally Acceptable Primary Explosive, DBX-1 SO ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE LA English DT Article DE Tetrazoles; Tetrazines; High energy density materials; Nitrogen-rich compounds; Energetic materials ID LEAD AZIDE; REPLACEMENT AB Sodium 5-nitrotetrazolate dihydrate (NaNT) is a useful precursor compound for the synthesis of lead-free primary explosives; however, currently employed syntheses for the compound are tedious, dangerous, and plagued by impurities. Through comprehensive analysis, we elucidate the identity of the most detrimental impurities and further report an improved procedure for preparation of NaNT, which greatly improves the purity, while avoiding the handling of acid copper(II) nitrotetrazolate, a highly sensitive explosive intermediate. In the new procedure, 5-aminotetrazole is diazotized with sodium nitrite, cupric sulfate, and nitric acid. Copper is precipitated as its oxide and the aqueous solution evaporated. After soxhlet extraction with acetone, large crystals of NaNT are obtained. The prepared material is suitable for preparation of lead azide replacement DBX-1 [copper(I) 5-nitrotetrazolate] as evidenced by successful use in M55 stab detonators. C1 [Klapoetke, Thomas M.; Piercey, Davin G.] Univ Munich, Dept Chem, D-81377 Munich, Germany. [Mehta, Neha; Oyler, Karl D.] USA, Explos Dev Branch, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Jorgensen, Matthew; Lenahan, Shannon; Salan, Jerry S.] Nalas Engn Serv Inc, Centerbrook, CT 06409 USA. [Fronabarger, John W.; Williams, Michael D.] Pacific Sci Energet Mat Co, Chandler, AZ 85226 USA. RP Klapotke, TM (reprint author), Univ Munich, Dept Chem, Butenandtstr 5-13 D, D-81377 Munich, Germany. EM tmk@cup.uni-muenchen.de RI Klapoetke, Thomas/B-6055-2014 OI Klapoetke, Thomas/0000-0003-3276-1157 FU Ludwig-Maximilian University of Munich (LMU); U.S. Army Research Laboratory (ARL); RDECOM Ordnance Environmental Program (OEP); Strategic Environmental Research and Development Program (SERDP); Office of Naval Research (ONR Global) [W911NF-09-2-0018, W911NF-09-1-0120, W011NF-09-1-0056, W911NF-12-1-0467, 10 WPSEED01-002 / WP-1765]; Navy ManTech program FX Financial support of this work by the Ludwig-Maximilian University of Munich (LMU), the U.S. Army Research Laboratory (ARL), the RDECOM Ordnance Environmental Program (OEP), Project Director for Joint Services (PD-JS), the Strategic Environmental Research and Development Program (SERDP), and the Office of Naval Research (ONR Global, title: "Synthesis and Characterization of New High Energy Dense Oxidizers (HEDO) - NICOP Effort") under contract nos. W911NF-09-2-0018 (ARL), W911NF-09-1-0120 (ARDEC), W011NF-09-1-0056 (ARDEC), W911NF-12-1-0467, and 10 WPSEED01-002 / WP-1765 (SERDP) is gratefully acknowledged. The authors acknowledge collaborations with Dr. Mila Krupka (OZM Research, Czech Republic) in the development of new testing and evaluation methods for energetic materials and with Dr. Muhamed Sucesca (Brodarski Institute, Croatia) in the development of new computational codes to predict the detonation and propulsion parameters of novel explosives. We gratefully acknowledge support and guidance given by Steven Gilbert, Kaitlyn Zienowicz, and John Hirlinger of ARDEC as well as Magdy Bichay of the U.S. NSWC Indian Head. We are indebted to and thank Drs. Betsy M. Rice and Brad Forch (ARL, Aberdeen, Proving Ground, MD) and Mr. Gary Chen (ARDEC, Picatinny Arsenal, NJ) for many helpful and inspired discussions and support of our work. The authors want to thank St. Huber for measuring the sensitivities. PSEMC would like to acknowledge Mr. Chuck Painter and the Navy ManTech program for funding. NR 18 TC 14 Z9 14 U1 1 U2 39 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0044-2313 J9 Z ANORG ALLG CHEM JI Z. Anorg. Allg. Chem. PD APR PY 2013 VL 639 IS 5 BP 681 EP 688 DI 10.1002/zaac.201300010 PG 8 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 132WJ UT WOS:000318099100005 ER PT J AU Zapata, LE Portela, G Suarez, OM Carrasquillo, O AF Zapata, L. E. Portela, G. Suarez, O. M. Carrasquillo, O. TI Rheological performance and compressive strength of superplasticized cementitious mixtures with microinano-SiO2 additions SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE Portland cement; Compressive strength; Marsh cone test; Nano-SiO2; Silica fume ID SELF-COMPACTING CONCRETE; MECHANICAL-PROPERTIES; MINERAL ADMIXTURES; SILICA FUME; NANO-SIO2; PASTES; NANOPARTICLES; PARTICLES; FLUIDITY; MORTAR AB This study aims to assess the effects of micro and nano-SiO2 under various dosages of carboxylated-polyether-copolymer-type superplasticizer on the rheological properties of grouts in the fresh state. In the hardened state, compressive tests and scanning electron microscopy were used to characterize type I Portland cement mortars. During Stage-I, the rheology of superplasticized grouts (w/b = 0.35 and 0.40) was obtained by the Marsh cone test. Mineral admixtures in superplasticized grouts decrease the flow times and the saturation dosages when compared to the superplasticized-control specimens. In Stage-II, experimental designs at w/b = 0.35 produced flow area, unit weight and air content in mineral admixture-systems better than in superplasticized-control samples. During Stage-III, the maximum strength in the nano-SiO2-system was obtained at 1.0 wt%, whereas in micro-SiO2-systems, this effect occurred at 15 wt%. SEM examinations in the interfacial transition zone suggest that compressive strengths of nano-SiO2-systems were controlled by both densification and filler effects, whereas micro-SiO2-systems were controlled only by the latter. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Zapata, L. E.] Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR USA. [Portela, G.; Suarez, O. M.] Univ Puerto Rico, Dept Engn Sci & Mat, Mayaguez, PR 00708 USA. [Carrasquillo, O.] USA, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. RP Portela, G (reprint author), Univ Puerto Rico, Dept Engn Sci & Mat, Mayaguez, PR 00708 USA. EM genock.portela@upr.edu OI Suarez, Oscar/0000-0002-3797-4787 NR 40 TC 21 Z9 21 U1 5 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD APR PY 2013 VL 41 BP 708 EP 716 DI 10.1016/j.conbuildmat.2012.12.025 PG 9 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 125GS UT WOS:000317528900078 ER PT J AU Govoni, MA Li, HB Kosinski, JA AF Govoni, Mark A. Li, Hongbin Kosinski, John A. TI Low Probability of Interception of an Advanced Noise Radar Waveform with Linear-FM SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Editorial Material ID SAR; ECCM AB This research considers an advanced pulse compression noise (APCN) radar waveform possessing salient features from linear-FM (LFM) and noise waveforms. A cross-correlation model considering several chirp waveform profiles is used to simulate the output of a passive electronic intelligence (ELINT) intercept-receiver. By doing so we are able to demonstrate the low probability of interception (LPI) characteristic of the APCN waveform for different kappa values. C1 [Govoni, Mark A.] USA, CERDEC, Div Radar, Aberdeen Proving Ground, MD 21005 USA. [Li, Hongbin] Stevens Inst Technol, Hoboken, NJ 07030 USA. [Kosinski, John A.] Monmouth Univ, W Long Branch, NJ 07764 USA. [Kosinski, John A.] MacAulay Brown, Dayton, OH 45430 USA. RP Govoni, MA (reprint author), USA, CERDEC, Div Radar, Aberdeen Proving Ground, MD 21005 USA. NR 22 TC 13 Z9 14 U1 3 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD APR PY 2013 VL 49 IS 2 BP 1351 EP 1356 PG 6 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 127AY UT WOS:000317667700046 ER PT J AU Farmer, AR Murray, CK Mende, K Akers, KS Zera, WC Beckius, ML Yun, HC AF Farmer, Aaron R. Murray, Clinton K. Mende, Katrin Akers, Kevin S. Zera, Wendy C. Beckius, Miriam L. Yun, Heather C. TI Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities for Gram-Negative rods SO JOURNAL OF BASIC MICROBIOLOGY LA English DT Article DE Antimicrobial susceptibilities; Gram negative rod; HMG-CoA reductase inhibitors ID IN-VITRO; STATINS AB Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated. C1 [Farmer, Aaron R.; Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.; Zera, Wendy C.; Yun, Heather C.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. [Murray, Clinton K.; Mende, Katrin; Akers, Kevin S.; Zera, Wendy C.; Yun, Heather C.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Murray, Clinton K.; Akers, Kevin S.; Yun, Heather C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin; Zera, Wendy C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Beckius, Miriam L.] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX USA. RP Farmer, AR (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM aaron.farmer@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 18 TC 5 Z9 5 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0233-111X J9 J BASIC MICROB JI J. Basic Microbiol. PD APR PY 2013 VL 53 IS 4 BP 336 EP 339 DI 10.1002/jobm.201100614 PG 4 WC Microbiology SC Microbiology GA 131BO UT WOS:000317966000006 PM 22736455 ER EF