FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Redcay, E Moran, JM Mavros, PL Tager-Flusberg, H Gabrieli, JDE Whitfield-Gabrieli, S AF Redcay, Elizabeth Moran, Joseph M. Mavros, Penelope L. Tager-Flusberg, Helen Gabrieli, Johnd D. E. Whitfield-Gabrieli, Susan TI Intrinsic functional network organization in high-functioning adolescents with autism spectrum disorder SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE autism; resting-state functional connectivity; default mode network; intrinsic network organization; graph theory; functional MRI ID RESTING HUMAN BRAIN; WHITE-MATTER; DEFAULT MODE; SENTENCE COMPREHENSION; ASPERGER SYNDROME; SOCIAL COGNITION; STATE NETWORKS; BASE-LINE; CONNECTIVITY; CORTEX AB Converging theories and data suggest that atypical patterns of functional and structural connectivity are a hallmark neurobiological feature of autism. However, empirical studies of functional connectivity, or, the correlation of MRI signal between brain regions, have largely been conducted during task performance and/or focused on group differences within one network [e.g., the default mode network (DMN)]. This narrow focus on task-based connectivity and single network analyses precludes investigation of whole-brain intrinsic network organization in autism. To assess whole-brain network properties in adolescents with autism, we collected resting-state functional connectivity MRI (rs-fcMRI) data from neurotypical (NT) adolescents and adolescents with autism spectrum disorder (ASD). We used graph theory metrics on rs-fcMRI data with 34 regions of interest (i.e., nodes) that encompass four different functionally defined networks: cingulo-opercular, cerebellar, fronto-parietal, and DMN (Fair et al., 2009). Contrary to our hypotheses, network analyses revealed minimal differences between groups with one exception. Betweenness centrality, which indicates the degree to which a seed (or node) functions as a hub within and between networks, was greater for participants with autism for the right lateral parietal (RLatP) region of the DMN. Follow-up seed-based analyses demonstrated greater functional connectivity in ASD than NT groups between the RLatP seed and another region of the DMN, the anterior medial prefrontal cortex. Greater connectivity between these regions was related to lower ADOS (Autism Diagnostic Observation Schedule) scores (i.e., lower impairment) in autism. These findings do not support current theories of underconnectivity in autism, but, rather, underscore the need for future studies to systematically examine factors that can influence patterns of intrinsic connectivity such as autism severity, age, and head motion. C1 [Redcay, Elizabeth] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA. [Moran, Joseph M.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA. [Moran, Joseph M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. [Mavros, Penelope L.] MIT, Simons Ctr Social Brain, Cambridge, MA 02139 USA. [Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA. [Gabrieli, Johnd D. E.; Whitfield-Gabrieli, Susan] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA. [Gabrieli, Johnd D. E.; Whitfield-Gabrieli, Susan] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA. RP Redcay, E (reprint author), Univ Maryland, Dept Psychol, 1147 Biol Psychol Bldg, College Pk, MD 20742 USA. EM redcay@umd.edu FU Boston Autism Consortium; Eunice Kennedy Shriver National Institute of Child Health and Human Development FX We gratefully acknowledge the Boston Autism Consortium for providing funding support for this project. We also wish to thank Dr. Charles A. Nelson, Dr. Tal Kenet, and Dr. Robert Joseph for their contributions to this multi-site project that made collection of these data possible, including recruitment and assessment of participants with ASD. We also thank Dr. Jasmin Cloutier and Daniel O'Young for assistance with data collection and the Athinoula A. Martinos Imaging Center at the McGovern Institute for Brain Research at MIT, particularly Dr. Christina Triantafyllou for development of the current resting-state imaging protocol. We also are grateful to the Eunice Kennedy Shriver National Institute of Child Health and Human Development for a postdoctoral fellowship to Elizabeth Redcay. NR 82 TC 37 Z9 37 U1 9 U2 26 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD SEP 19 PY 2013 VL 7 AR 573 DI 10.3389/fnhum.2013.00573 PG 11 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 220GU UT WOS:000324571600001 PM 24062673 ER PT J AU Lawhern, V Kerick, S Robbins, KA AF Lawhern, Vernon Kerick, Scott Robbins, Kay A. TI Detecting alpha spindle events in EEG time series using adaptive autoregressive models SO BMC NEUROSCIENCE LA English DT Article DE Alpha spindle; Adaptive autoregressive model; Classification; Electroencephalography; Time series; Fatigue; Change point detection ID INDEPENDENT COMPONENT ANALYSIS; HIGH-FREQUENCY OSCILLATIONS; MATCHING PURSUIT; SLEEP SPINDLES; CLASSIFICATION; DROWSINESS; SYNCHRONIZATION; SEGMENTATION; WAKEFULNESS; ARTIFACTS AB Background: Rhythmic oscillatory activity is widely observed during a variety of subject behaviors and is believed to play a central role in information processing and control. A classic example of rhythmic activity is alpha spindles, which consist of short (0.5-2 s) bursts of high frequency alpha activity. Recent research has shown that alpha spindles in the parietal/occipital area are statistically related to fatigue and drowsiness. These spindles constitute sharp changes in the underlying statistical properties of the signal. Our hypothesis is that change point detection models can be used to identify the onset and duration of spindles in EEG. In this work we develop an algorithm that accurately identifies sudden bursts of narrowband oscillatory activity in EEG using techniques derived from change point analysis. Our motivating example is detection of alpha spindles in the parietal/occipital areas of the brain. Our goal is to develop an algorithm that can be applied to any type of rhythmic oscillatory activity of interest for accurate online detection. Methods: In this work we propose modeling the alpha band EEG time series using discounted autoregressive (DAR) modeling. The DAR model uses a discounting rate to weigh points measured further in the past less heavily than points more recently observed. This model is used together with predictive loss scoring to identify periods of EEG data that are statistically significant. Results: Our algorithm accurately captures changes in the statistical properties of the alpha frequency band. These statistical changes are highly correlated with alpha spindle occurrences and form a reliable measure for detecting alpha spindles in EEG. We achieve approximately 95% accuracy in detecting alpha spindles, with timing precision to within approximately 150 ms, for two datasets from an experiment of prolonged simulated driving, as well as in simulated EEG. Sensitivity and specificity values are above 0.9, and in many cases are above 0.95, for our analysis. Conclusion: Modeling the alpha band EEG using discounted AR models provides an efficient method for detecting oscillatory alpha activity in EEG. The method is based on statistical principles and can generally be applied to detect rhythmic activity in any frequency band or brain region. C1 [Lawhern, Vernon; Robbins, Kay A.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. [Lawhern, Vernon; Kerick, Scott] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen, MD 21005 USA. RP Lawhern, V (reprint author), Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. EM vlawhern@cs.utsa.edu FU DCS Corporation; Army Research Laboratory [W911NF-10-2-0022] FX The authors wish to thank W. David Hairston and Kaleb McDowell, both with the Army Research Laboratory, for helpful discussions, and DCS Corporation for the support and development of the experimental design used in this study. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 55 TC 6 Z9 7 U1 2 U2 24 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2202 J9 BMC NEUROSCI JI BMC Neurosci. PD SEP 18 PY 2013 VL 14 AR 101 DI 10.1186/1471-2202-14-101 PG 16 WC Neurosciences SC Neurosciences & Neurology GA 221VU UT WOS:000324688900001 PM 24047117 ER PT J AU Linkov, I Eisenberg, DA Bates, ME Chang, D Convertino, M Allen, JH Flynn, SE Seager, TP AF Linkov, Igor Eisenberg, Daniel A. Bates, Matthew E. Chang, Derek Convertino, Matteo Allen, Julia H. Flynn, Stephen E. Seager, Thomas P. TI Measurable Resilience for Actionable Policy SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material ID SYSTEMS C1 [Linkov, Igor; Eisenberg, Daniel A.; Bates, Matthew E.; Chang, Derek; Convertino, Matteo] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA. [Allen, Julia H.] Carnegie Mellon Univ, Inst Software Engn, CERT Program, Pittsburgh, PA 15289 USA. [Flynn, Stephen E.] Northeastern Univ, Kostas Res Inst Homeland Secur, Dept Polit Sci, Boston, MA 02115 USA. [Seager, Thomas P.] Arizona State Univ, Sch Engn & Built Environm, Tempe, AZ 85287 USA. RP Linkov, I (reprint author), 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil NR 4 TC 12 Z9 23 U1 1 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 17 PY 2013 VL 47 IS 18 BP 10108 EP 10110 DI 10.1021/es403443n PG 3 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 295DE UT WOS:000330096000005 PM 23998295 ER PT J AU Sabatini, JJ Moretti, JD AF Sabatini, Jesse J. Moretti, Jared D. TI High-Nitrogen-Based Pyrotechnics: Perchlorate-Free Red- and Green-Light Illuminants Based on 5-Aminotetrazole SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE energetic materials; illuminants; nitrogen heterocycles; pyrotechnics; sustainable chemistry ID CIVILIAN APPLICATIONS; MILITARY AB Prototype testing of perchlorate-free hand-held signal illuminants for the US Army's M126A1 red-star and M195 green-star parachute illuminants are described. Although previous perchlorate-free variants for these items have been developed based on high-nitrogen compounds that are not readily available, the new formulations consist of anhydrous 5-aminotetrazole as the suitable perchlorate replacement. Compared to the perchlorate-containing control, the disclosed illuminants exhibited excellent stabilities toward various ignition stimuli and had excellent pyrotechnic performance. The illuminants are important from both military and civil fireworks perspectives, as the perchlorate-free nature of the illuminants adequately address environmental concerns associated with perchlorate-containing red- and green-light-emitting illuminants. C1 [Sabatini, Jesse J.; Moretti, Jared D.] US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. RP Sabatini, JJ (reprint author), US Army, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Bldg 3124, Picatinny Arsenal, NJ 07806 USA. EM jesse.j.sabatini.civ@mail.mil; jared.d.moretti.civ@mail.mil FU Environmental Quality Technology Program; Ordnance Environmental Program; US Army (Picatinny Arsenal, NJ) FX The authors are indebted to the Environmental Quality Technology and Ordnance Environmental Programs, and the US Army (Picatinny Arsenal, NJ) for funding of this work. The efforts of Ms. Jessica A. Vanatta in obtaining particle size and thermal onset data are gratefully acknowledged. The authors thank Dr. Jay C. Poret (Picatinny Arsenal, NJ) for his assistance in setting up the light detector and spectrometer prior to light tunnel testing, and for his assistance in using Labview (TM)-based data acquisition and analysis software. NR 28 TC 10 Z9 10 U1 0 U2 18 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD SEP 16 PY 2013 VL 19 IS 38 BP 12839 EP 12845 DI 10.1002/chem.201300779 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 216WH UT WOS:000324316300038 PM 23950104 ER PT J AU Vincenti, MA de Ceglia, D Grande, M D'Orazio, A Scalora, M AF Vincenti, M. A. de Ceglia, D. Grande, M. D'Orazio, A. Scalora, M. TI Nonlinear control of absorption in one-dimensional photonic crystal with graphene-based defect SO OPTICS LETTERS LA English DT Article ID ATOMIC-LAYER GRAPHENE; SATURABLE ABSORBER; BILAYER GRAPHENE; LASER; TRANSPARENT; PLASMONICS; ELECTRODES; FILMS AB Perfect, narrow-band absorption is achieved in an asymmetric 1D photonic crystal with a monolayer graphene defect. Thanks to the large third-order nonlinearity of graphene and field localization in the defect layer we demonstrate the possibility to achieve controllable, saturable absorption for the pump frequency. (C) 2013 Optical Society of America C1 [Vincenti, M. A.; de Ceglia, D.] AMRDEC, Charles M Bowden Res Lab, Natl Res Council, Redstone Arsenal, AL 35898 USA. [Grande, M.; D'Orazio, A.] Politecn Bari, DIEI, I-70126 Bari, Italy. [Scalora, M.] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), AMRDEC, Charles M Bowden Res Lab, Natl Res Council, Redstone Arsenal, AL 35898 USA. EM maria.vincenti@us.army.mil RI Petruzzelli, Vincenzo/H-5188-2012 OI Petruzzelli, Vincenzo/0000-0001-6921-9981 FU U.S. Army International Technology Center Atlantic [W911NF-12-1-0292] FX This research was performed while the authors M. A. Vincenti and D. de Ceglia held National Research Council Research Associateship awards at the U. S. Army Aviation and Missile Research Development and Engineering Center. M. Grande thanks the U.S. Army International Technology Center Atlantic for financial support (W911NF-12-1-0292). NR 32 TC 24 Z9 26 U1 5 U2 54 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 15 PY 2013 VL 38 IS 18 BP 3550 EP 3553 DI 10.1364/OL.38.003550 PG 4 WC Optics SC Optics GA 228TH UT WOS:000325212800021 PM 24104811 ER PT J AU Willis, MP Gordon, W Lalain, T Mantooth, B AF Willis, Matthew P. Gordon, Wesley Lalain, Teri Mantooth, Brent TI Characterization of chemical agent transport in paints SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Chemical warfare agent; HD (sulfur mustard); VX; Material decontamination; Diffusivity ID VOLATILE ORGANIC-COMPOUNDS; DRY BUILDING MATERIAL; SULFUR MUSTARD; WARFARE AGENT; PARTITION-COEFFICIENTS; DIFFUSION; SORPTION; PERMEATION; METHODOLOGY; SUBSTRATE AB A combination of vacuum-based vapor emission measurements with a mass transport model was employed to determine the interaction of chemical warfare agents with various materials, including transport parameters of agents in paints. Accurate determination of mass transport parameters enables the simulation of the chemical agent distribution in a material for decontaminant performance modeling. The evaluation was performed with the chemical warfare agents bis(2-chloroethyl) sulfide (distilled mustard, known as the chemical warfare blister agent HD) and O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX), an organophosphate nerve agent, deposited on to two different types of polyurethane paint coatings. The results demonstrated alignment between the experimentally measured vapor emission flux and the predicted vapor flux. Mass transport modeling demonstrated rapid transport of VX into the coatings; VX penetrated through the aliphatic polyurethane-based coating (100 mu m) within approximately 107 min. By comparison, while HD was more soluble in the coatings, the penetration depth in the coatings was approximately 2x lower than VX. Applications of mass transport parameters include the ability to predict agent uptake, and subsequent long-term vapor emission or contact transfer where the agent could present exposure risks. Additionally, these parameters and model enable the ability to perform decontamination modeling to predict how decontaminants remove agent from these materials. Published by Elsevier B.V. C1 [Willis, Matthew P.; Gordon, Wesley; Lalain, Teri; Mantooth, Brent] US Army, RDECOM, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Willis, MP (reprint author), US Army, RDECOM, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM matthew.p.willis.civ@mail.mil FU Defense Threat Reduction Agency [CA09MSB317] FX This work represents the cumulative results from two research programs funded by Eric Lowenstein and Michael Roberts (Defense Threat Reduction Agency) under program CA09MSB317. The authors thank Erin Durke Davis for experimental support and helpful discussions and Tom Pearl and Mark Varady for editing. The technical report cited within this paper [21] is available at http://www.dtic.mil and the specification documents [19,20] are available at https://assist.daps.dla.mil. NR 27 TC 4 Z9 4 U1 1 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD SEP 15 PY 2013 VL 260 BP 907 EP 913 DI 10.1016/j.jhazmat.2013.06.041 PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 220DZ UT WOS:000324563500110 PM 23872337 ER PT J AU Ye, YS Stokes, KK Beyer, FL Elabd, YA AF Ye, Yuesheng Stokes, Kristoffer K. Beyer, Frederick L. Elabd, Yossef A. TI Development of phosphonium-based bicarbonate anion exchange polymer membranes SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Ion exchange; Phosphonium; Bicarbonate; Water purification; Desalination ID THERMAL-DECOMPOSITION; ION-EXCHANGE; WASTE-WATER; FUEL-CELLS; STOICHIOMETRY; TEMPERATURE; COPOLYMERS; HYDROXIDES; STABILITY; MECHANISM AB We report the preparation and characterization of phosphonium-based bicarbonate anion exchange random copolymers, poly(styrene-random-trimethylvinylbenzyl phosphonium bicarbonate) (poly(S-r-TMVBP-HCO3)). Compared to the chloride anion (Cl-) exchange membranes, these HCO3- exchange membranes exhibit similar hydration levels and only slightly lower ionic conductivities at similar ionic compositions. Other experiments reveal that the HCO3- exchange membranes are thermally stable (up to 110 degrees C) and chemically stable under relatively low alkaline conditions. Additionally, a detailed chemical degradation mechanism for these membranes under strong alkaline conditions is presented. (C) 2013 Elsevier B.V. All rights reserved. C1 [Ye, Yuesheng; Elabd, Yossef A.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Stokes, Kristoffer K.; Beyer, Frederick L.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Elabd, YA (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM elabd@drexel.edu RI Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 FU U.S. Army Research Laboratory [ORISE 1120-1120-99]; U.S. Army Research Office under Ionic Liquids in Electro-Active Devices (ILEAD) MURI [W911NF-07-1 0452]; U.S. Department of Energy [ORISE 1120-1120-99] FX This material is based upon work supported by, or in part by, the U.S. Army Research Laboratory and the U.S. Army Research Office under contract/grant number W911NF-07-1 0452, Ionic Liquids in Electro-Active Devices (ILEAD) MURI. This research was supported in part by the appointment of Dr. Stokes to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Research Laboratory under contract number ORISE 1120-1120-99. NR 31 TC 18 Z9 18 U1 2 U2 83 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 J9 J MEMBRANE SCI JI J. Membr. Sci. PD SEP 15 PY 2013 VL 443 BP 93 EP 99 DI 10.1016/j.memsci.2013.04.053 PG 7 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 168HI UT WOS:000320696000011 ER PT J AU Hooper, JW Josleyn, M Ballantyne, J Brocato, R AF Hooper, Jay W. Josleyn, Matthew Ballantyne, John Brocato, Rebecca TI A novel Sin Nombre virus DNA vaccine and its inclusion in a candidate pan-hantavirus vaccine against hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) SO VACCINE LA English DT Article DE Sin Nombre virus; Hantavirus; DNA vaccine; HPS; HFRS ID NEUTRALIZING ANTIBODY-RESPONSE; MOUSE PEROMYSCUS-MANICULATUS; SUPPORT IMPROVES SURVIVAL; HANTAAN-VIRUS; CARDIOPULMONARY SYNDROME; MONOCLONAL-ANTIBODIES; PASSIVE-IMMUNIZATION; NONHUMAN-PRIMATES; PROTECTS HAMSTERS; ANDES VIRUS AB Sin Nombre virus (SNV; family Bunyaviridae, genus Hantavirus) causes a hemorrhagic fever known as hantavirus pulmonary syndrome (HPS) in North America. There have been approximately 200 fatal cases of HPS in the United States since 1993, predominantly in healthy working-age males (case fatality rate 35%). There are no FDA-approved vaccines or drugs to prevent or treat HPS. Previously, we reported that hantavirus vaccines based on the full-length M gene segment of Andes virus (ANDV) for HPS in South America, and Hantaan virus (HTNV) and Puumala virus (PUUV) for hemorrhagic fever with renal syndrome (HFRS) in Eurasia, all elicited high-titer neutralizing antibodies in animal models. HFRS is more prevalent than HPS (>20,000 cases per year) but less pathogenic (case fatality rate 1-15%). Here, we report the construction and testing of a SNV full-length M gene-based DNA vaccine to prevent HPS. Rabbits vaccinated with the SNV DNA vaccine by muscle electroporation (mEP) developed high titers of neutralizing antibodies. Furthermore, hamsters vaccinated three times with the SNV DNA vaccine using a gene gun were completely protected against SNV infection. This is the first vaccine of any kind that specifically elicits high-titer neutralizing antibodies against SNV. To test the possibility of producing a pan-hantavirus vaccine, rabbits were vaccinated by mEP with an HPS mix (ANDV and SNV plasmids), or HFRS mix (HTNV and PUUV plasmids), or HPS/HFRS mix (all four plasmids). The HPS mix and HFRS mix elicited neutralizing antibodies predominantly against ANDV/SNV and HTNV/PUUV, respectively. Furthermore, the HPS/HFRS mix elicited neutralizing antibodies against all four viruses. These findings demonstrate a pan-hantavirus vaccine using a mixed-plasmid DNA vaccine approach is feasible and warrants further development. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Hooper, Jay W.; Josleyn, Matthew; Brocato, Rebecca] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Ballantyne, John] Aldevron LLC, Fargo, ND USA. RP Hooper, JW (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM Jay.W.Hooper@us.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU U.S. Army Medical Research and Material Command, Military Infectious Disease Research Program, Program Area T; NIH [R01 AI098933-01]; Chemical, Biological Medical Systems (CBMS) [W9113M-08-1-0008] FX The Elgen electroporation device was provided by Inovio. The TriGrid device was provided by Ichor. The research gene gun and pWRG7077 were provided by Powderject Vaccine, Inc. A modified version of pWRG7077 containing the BstB1 restriction site was provided by Alexander Dekonenko. The pPUUSXdelta plasmid used to produce the N-ELISA antigen in E. coil were provided by Fredrick Elgh, Umea, Sweden. This work was funded by the U.S. Army Medical Research and Material Command, Military Infectious Disease Research Program, Program Area T; NIH R01 AI098933-01 (Hooper); and Chemical, Biological Medical Systems (CBMS) Award Number W9113M-08-1-0008. Opinions, interpretations, conclusions, and recommendations are ours and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 36 TC 10 Z9 10 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 13 PY 2013 VL 31 IS 40 BP 4314 EP 4321 DI 10.1016/j.vaccine.2013.07.025 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 219MG UT WOS:000324510500009 PM 23892100 ER PT J AU Borodin, O Henderson, WA Fox, ET Berman, M Gobet, M Greenbaum, S AF Borodin, Oleg Henderson, Wesley A. Fox, Eric T. Berman, Marc Gobet, Mallory Greenbaum, Steve TI Influence of Solvent on Ion Aggregation and Transport in PY15TFSI Ionic Liquid-Aprotic Solvent Mixtures SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; HIGH-TEMPERATURE LUBRICANTS; FORCE-FIELD; THERMOPHYSICAL PROPERTIES; POLYETHYLENE-GLYCOL; BINARY-MIXTURES; ELECTROLYTES; ACETONITRILE; WATER; CONDUCTIVITY AB Molecular dynamics (MD) simulations using a many-body polarizable APPLE&P force field have been performed on mixtures of the N-methyl-N-pentylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PY15TFSI) ionic liquid (IL) with three molecular solvents: propylene carbonate (PC), dimethyl carbonate (DMC), and acetonitrile (AN). The MD simulations predict density, viscosity, and ionic conductivity values that agree well with the experimental results. In the solvent-rich regime, the ionic conductivity of the PY15TFSI-AN mixtures was found to be significantly higher than the conductivity of the corresponding -PC and -DMC mixtures, despite the similar viscosity values obtained from both the MD simulations and experiments for the -DMC and -AN mixtures. The significantly lower conductivity of the PY15TFSI-DMC mixtures, as compared to those for PY15TFSI-AN, in the solvent-rich regime was attributed to the more extensive ion aggregation observed for the -DMC mixtures. The PY15TFSI-DMC mixtures present an interesting case where the addition of the organic solvent to the IL results in an increase in the cation-anion correlations, in contrast to what is found for the mixtures with PC and AN, where ion motion became increasingly uncorrelated with addition of solvent. A combination of pfg-NMR and conductivity measurements confirmed the MD simulation predictions. Further insight into the molecular interactions and properties was also obtained using the MD simulations by examining the solvent distribution in the IL-solvent mixtures and the mixture excess properties. C1 [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. [Henderson, Wesley A.; Fox, Eric T.] N Carolina State Univ, Dept Chem & Biomol Engn, ILEET Lab, Raleigh, NC 27695 USA. [Berman, Marc; Gobet, Mallory; Greenbaum, Steve] CUNY, Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA. RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil; whender@ncsu.edu RI Gobet, Mallory/I-2498-2013; Borodin, Oleg/B-6855-2012 OI Gobet, Mallory/0000-0001-9735-0741; Borodin, Oleg/0000-0002-9428-5291 FU Multiscale Modeling Program; DOE Division of Materials Sciences Engineering [DE-SC0005029]; DOE Division of Materials Chemistry [DE-DC0001912] FX The authors wish to express their gratitude to the U.S. Department of Energy (DOE) which fully supported the experimental part of this work. The modeling work at ARL was supported by the Multiscale Modeling Program. The NMR measurements were supported by the DOE Division of Materials Sciences & Engineering under award DE-SC0005029. The synthesis of the PY15TFSI and additional experimental measurements was supported by the DOE Division of Materials Chemistry under award DE-DC0001912. NR 44 TC 15 Z9 15 U1 1 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 12 PY 2013 VL 117 IS 36 BP 10581 EP 10588 DI 10.1021/jp406541e PG 8 WC Chemistry, Physical SC Chemistry GA 296BX UT WOS:000330161200024 PM 23941158 ER PT J AU Mitchell, BL Bhandari, RK Bebarta, VS Rockwood, GA Boss, GR Logue, BA AF Mitchell, Brendan L. Bhandari, Raj K. Bebarta, Vikhyat S. Rockwood, Gary A. Boss, Gerry R. Logue, Brian A. TI Toxicokinetic profiles of alpha-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide SO TOXICOLOGY LETTERS LA English DT Article DE Cyanide exposure; alpha-Ketoglutarate cyanohydrin; Toxicokinetics; alpha-Ketoglutarate ID CHROMATOGRAPHY-MASS-SPECTROMETRY; 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; LIQUID-CHROMATOGRAPHY; SODIUM THIOSULFATE; HUMAN PLASMA; WHOLE-BLOOD; MOUSE-LIVER; COBINAMIDE; CYANOCOBALAMIN; INTOXICATION AB Poisoning by cyanide can be verified by analysis of the cyanide detoxification product, alpha-ketoglutarate cyanohydrin (alpha-KgCN), which is produced from the reaction of cyanide and endogenous alpha-ketoglutarate. Although alpha-KgCN can potentially be used to verify cyanide exposure, limited toxicokinetic data in cyanide-poisoned animals are available. We, therefore, studied the toxicokinetics of a-KgCN and compared its behavior to other cyanide metabolites, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid (ATCA), in the plasma of 31 Yorkshire pigs that received KCN (4 mg/mL) intravenously (IV) (0.17 mg/kg/min). alpha-KgCN concentrations rose rapidly during KCN administration until the onset of apnea, and then decreased over time in all groups with a half-life of 15 min. The maximum concentrations of alpha-KgCN and cyanide were 2.35 and 30.18 p,M, respectively, suggesting that only a small fraction of the administered cyanide is converted to alpha-KgCN. Although this is the case, the alpha-KgCN concentration increased >100-fold over endogenous concentrations compared to only a three-fold increase for cyanide and ATCA. The plasma profile of alpha-KgCN was similar to that of cyanide, ATCA, and thiocyanate. The results of this study suggest that the use of alpha-KgCN as a biomarker for cyanide exposure is best suited immediately following exposure for instances of acute, high-dose cyanide poisoning. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Mitchell, Brendan L.; Bhandari, Raj K.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu RI bebarta, vikhyat/K-3476-2015 FU CounterACT Program, National Institutes of Health Office of the Director [U01NS058030]; National Institute of Allergy and Infectious Diseases [OD12060-001-00000/A120-B.P2012-01]; USAMRICD under US Army Research Office of Scientific Services Program [W911NF-11-D-0001, TCN 11077]; U.S. Dept. of Education, Graduate Assistance in Areas of National Need (GAANN) [P200A100103]; National Science Foundation Major Research Instrumentation Program [CHE-0922816]; AB SCIEX QTRAP 5500 LC/MS/MS; National Science Foundation/EPSCoR [0091948]; State of South Dakota FX The research was supported by the CounterACT Program, National Institutes of Health Office of the Director, Grant Nu. U01NS058030, the National Institute of Allergy and Infectious Diseases, Inter agency Agreement Number AOD12060-001-00000/A120-B.P2012-01 and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program Contract No. W911NF-11-D-0001 administered by Battelle (Delivery order 0079, Contract No. TCN 11077). We gratefully acknowledge the support from a U.S. Dept. of Education, Graduate Assistance in Areas of National Need (GAANN), award to the Department of Chemistry & Biochemistry (P200A100103). We thank the National Science Foundation Major Research Instrumentation Program (Grant Number CHE-0922816) for funding the AB SCIEX QTRAP 5500 LC/MS/MS. The LC/MS/MS instrumentation was housed in the South Dakota State University Campus Mass Spectrometry Facility which was supported by the National Science Foundation/EPSCoR Grant No. 0091948 and the State of South Dakota. The authors would like to acknowledge Dr. George Perry, Animal and Range Science (South Dakota State University) for providing swine plasma. Furthermore, the authors are thankful to Susan M. Boudreau, RN, BSN, Maria G. Castaneda, MS, Toni E. Vargas, PA-C, MHS, and Patricia Dixon, MHS from the Clinical Research Division, Wilford Hall Medical Center (Lackland Air Force Base, San Antonio, TX) for providing potassium cyanide-exposed swine plasma. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Air Force, the National Institutes of Health, or the Department of Defense. NR 52 TC 5 Z9 5 U1 0 U2 19 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD SEP 12 PY 2013 VL 222 IS 1 BP 83 EP 89 DI 10.1016/j.toxlet.2013.07.008 PG 7 WC Toxicology SC Toxicology GA 211AA UT WOS:000323875300009 PM 23867915 ER PT J AU Hall, AT Zovanyi, AM Christensen, DR Koehler, JW Minogue, TD AF Hall, Adrienne Trombley Zovanyi, Ashley McKay Christensen, Deanna Rose Koehler, Jeffrey William Minogue, Timothy Devins TI Evaluation of Inhibitor-Resistant Real-Time PCR Methods for Diagnostics in Clinical and Environmental Samples SO PLOS ONE LA English DT Article ID POLYMERASE-CHAIN-REACTION; DNA AMPLIFICATION; YERSINIA-PESTIS; NUCLEIC-ACID; ANTHRAX SPORES; SOIL SAMPLES; ASSAY; IDENTIFICATION; BLOOD; SERUM AB Polymerase chain reaction (PCR) is commonly used for pathogen detection in clinical and environmental samples. These sample matrices often contain inhibitors of PCR, which is a primary reason for sample processing; however, the purification process is highly inefficient, becoming unacceptable at lower signature concentrations. One potential solution is direct PCR assessment without sample processing. Here, we evaluated nine inhibitor-resistant PCR reagents for direct detection of Francisella tularensis in seven different clinical and environmental samples using an established real-time PCR assay to assess ability to overcome PCR inhibition. While several of these reagents were designed for standard PCR, the described inhibitor resistant properties (ex. Omni Klentaq can amplify target DNA samples of up to 20% whole blood or soil) led to our evaluation with real-time PCR. A preliminary limit of detection (LOD) was determined for each chemistry in whole blood and buffer, and LODs (20 replicates) were determined for the top five chemistries in each matrix (buffer, whole blood, sputum, stool, swab, soil, and sand). Not surprisingly, no single chemistry performed the best across all of the different matrices evaluated. For instance, Phusion Blood Direct PCR Kit, Phire Hot Start DNA polymerase, and Phire Hot Start DNA polymerase with STR Boost performed best for direct detection in whole blood while Phire Hot Start DNA polymerase with STR Boost were the only reagents to yield an LOD in the femtogram range for soil. Although not the best performer across all matrices, KAPA Blood PCR kit produced the most consistent results among the various conditions assessed. Overall, while these inhibitor resistant reagents show promise for direct amplification of complex samples by real-time PCR, the amount of template required for detection would not be in a clinically relevant range for most matrices. C1 [Hall, Adrienne Trombley; Zovanyi, Ashley McKay; Christensen, Deanna Rose; Koehler, Jeffrey William; Minogue, Timothy Devins] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Minogue, TD (reprint author), US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. EM timothy.d.minogue.civ@mail.mil OI Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency [8.10041_08_RD_B] FX This project was funded by the Defense Threat Reduction Agency (www.dtra.mil) under project # 8.10041_08_RD_B. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 13 Z9 13 U1 0 U2 18 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 9 PY 2013 VL 8 IS 9 AR e73845 DI 10.1371/journal.pone.0073845 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 244QV UT WOS:000326405300135 ER PT J AU Bedrov, D Borodin, O AF Bedrov, Dmitry Borodin, Oleg TI Atomistic molecular dynamics simulation study of mechanisms of formation and properties of solid electrolyte interphases in Li-ion batteries SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Bedrov, Dmitry] Univ Utah, Salt Lake City, UT 84112 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM d.bedrov@utah.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 337-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618402845 ER PT J AU Borodin, O Jow, TR Bedrov, D Xing, LD AF Borodin, Oleg Jow, T. Richard Bedrov, Dmitry Xing, Lidan TI Insight into electrolyte stability, decomposition, and transport properties from DFT and MD simulations SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc ID CARBONATE; ANIONS C1 [Borodin, Oleg; Jow, T. Richard] Army Res Lab, Adelph, MD USA. [Bedrov, Dmitry; Xing, Lidan] Univ Utah, Salt Lake City, UT USA. EM olegutah@gmail.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 2 TC 0 Z9 0 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 338-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618402846 ER PT J AU Cresce, AV Baker, DR Russell, SM Xu, K AF Cresce, Arthur V. Baker, David R. Russell, Selena M. Xu, Kang TI Effect of electrolyte additives on solid electrolyte interphase properties in Li-ion batteries as analyzed by in-situ atomic force microscopy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Cresce, Arthur V.; Baker, David R.; Russell, Selena M.; Xu, Kang] US Army, Res Lab, Electrochem Branch, Power & Energy Div,Sensor & Electron Devices Dire, Adelphi, MD 20783 USA. EM selena.russell.ctr@mail.mil NR 0 TC 0 Z9 0 U1 3 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 401-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618403345 ER PT J AU Hu, FS La Scala, JJ Sadler, JM Palmese, GR AF Hu, Fengshuo La Scala, John J. Sadler, Joshua M. Palmese, Giuseppe R. TI Synthesis and characterization of thermosetting furan-based epoxy materials with improved thermo-mechanical properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Hu, Fengshuo; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [La Scala, John J.; Sadler, Joshua M.] Army Res Labs, Dept Weap, Aberdeen, MD 21005 USA. [La Scala, John J.; Sadler, Joshua M.] Army Res Labs, Mat Res Directorate, Aberdeen, MD 21005 USA. EM fh83@drexel.edu NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 273-POLY PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618407036 ER PT J AU Hutchison, JM Poust, SK Kumar, M Cropek, DM MacAllister, IE Arnett, CM Zilles, JL AF Hutchison, Justin M. Poust, Sean K. Kumar, Manish Cropek, Donald M. MacAllister, Irene E. Arnett, Clint M. Zilles, Julie L. TI Hybrid nanoreactors composed of biomimetic vesicles and biological enzymes for perchlorate treatment SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Hutchison, Justin M.; Poust, Sean K.; Kumar, Manish; Zilles, Julie L.] Univ Illinois, Urbana, IL 61801 USA. [Cropek, Donald M.; MacAllister, Irene E.; Arnett, Clint M.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. EM hutchis2@illinois.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 184-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618403649 ER PT J AU Lambeth, RH Jackson, AC Beyer, FL AF Lambeth, Robert H. Jackson, Aaron C. Beyer, Frederick L. TI Model dynamic networks from metallo-supramolecular crosslinked polymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Lambeth, Robert H.; Jackson, Aaron C.; Beyer, Frederick L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM robert.h.lambeth2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 82-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618406439 ER PT J AU Moore, JD Larentzos, JP Izvekov, S Lisal, M Brennan, JK AF Moore, Joshua D. Larentzos, James P. Izvekov, Sergei Lisal, Martin Brennan, John K. TI Comprehensive suite of coarse-grain modeling tools formulated upon dissipative particle dynamics SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Moore, Joshua D.; Izvekov, Sergei; Brennan, John K.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Larentzos, James P.] US Army Res Lab, Dynam Res Corp, High Performance Technol Grp, Aberdeen Proving Ground, MD 21005 USA. [Lisal, Martin] ASCR, E Hala Lab Thermodynam, Inst Chem Proc Fundamentals, Vvi, Prague, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Usti Nad Labem, Czech Republic. EM joshua.d.moore8.ctr@us.army.mil NR 5 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 151-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618405859 ER PT J AU Soares, JW Arcidiacono, S Capela, P Racicot, K Chen, CYO AF Soares, Jason W. Arcidiacono, Steven Capela, Paul Racicot, Kenneth Chen, C-Y Oliver TI In vitro fecal fermentation of cranberry A-type proanthocyanidins SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Soares, Jason W.; Arcidiacono, Steven; Racicot, Kenneth] US Army Natick Soldier Res, Dev & Engn Command, Natick, MA 01760 USA. [Capela, Paul] Def Sci & Technol Org, Human Protect & Performance Div, Scottsdale, Tas 7260, Australia. [Chen, C-Y Oliver] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr, Boston, MA 02111 USA. EM jason.w.soares.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 186-AGFD PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618400254 ER PT J AU Zhang, Z Goshu, GM Ahern, AD Kostka, AA Jakkaraju, S Ruettiger, A Clare, M Sciotti, R Lee, PJ Horn, JR Begley, DW Hagen, TJ AF Zhang, Zheng Goshu, Gashaw M. Ahern, Adam D. Kostka, Aleksandra A. Jakkaraju, Sriram Ruettiger, Andrew Clare, Michael Sciotti, Richard Lee, Patricia J. Horn, James R. Begley, Darren W. Hagen, Timothy J. TI Discovery of imidazole based IspF inhibitors SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 246th National Meeting of the American-Chemical-Society (ACS) CY SEP 08-12, 2013 CL Indianapolis, IN SP Amer Chem Soc C1 [Zhang, Zheng; Goshu, Gashaw M.; Ahern, Adam D.; Kostka, Aleksandra A.; Jakkaraju, Sriram; Ruettiger, Andrew; Clare, Michael; Horn, James R.; Hagen, Timothy J.] No Illinois Univ, De Kalb, IL 60115 USA. [Sciotti, Richard; Lee, Patricia J.] Walter Reed Army Inst Res, Dept Expt Therapeut, Silver Spring, MD 20910 USA. [Begley, Darren W.] Emerald BioStruct, Dept Biophys, Bainbridge Isl, WA 98110 USA. EM zzhang1@niu.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 8 PY 2013 VL 246 MA 56-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 288NJ UT WOS:000329618404716 ER PT J AU Williams, CL Chen, CQ Ramesh, KT Dandekar, DP AF Williams, C. L. Chen, C. Q. Ramesh, K. T. Dandekar, D. P. TI The effects of cold rolling on the microstructural and spall response of 1100 aluminum SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DEFORMATION STRUCTURES; ROLLED ALUMINUM; FCC METALS; EVOLUTION; STRENGTH; TEXTURE; ALLOY AB As received 1100-O aluminum was cold rolled (CR) to 30%, 70%, and 80% reduction, respectively, to study the effects of microstructural evolution on the spall response using plate impact experiments. Previous results show a sharp increase in pullback velocity for 1100-O aluminum with increase in peak shock stress between 4.0 and 8.3GPa due to hardening, followed by a decrease for peak shock stresses up to 12.0GPa possibly due to softening. This maximum was not observed for the 30% CR, which showed only an increase in pullback velocity over the shock stress range of 4.0-12.0GPa due to hardening (net increase in dislocation density). For the 70% CR aluminum, no change was observed in the pullback velocity over the range tested (4.0-11.0GPa) probably due to saturation in dislocation density. Similar observations were made for the 80% CR, that is, no change was observed in the spall response between 4.0GPa and 11.0GPa. However, variations were observed in the spall response for the 80% CR, and these variations are attributed to material inhomogeneity possibly caused by increased cold rolling beyond saturation. The results also show a significant increase in Hugoniot Elastic Limit with increase in percent cold rolling. (C) 2013 AIP Publishing LLC. C1 [Williams, C. L.; Dandekar, D. P.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Chen, C. Q.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Williams, CL (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Chen, Changqiang/G-6310-2010 FU Army Research Laboratory [W911NF-06-2-0006] FX This work was sponsored by the Army Research Laboratory under ARMAC-RTP Cooperative Agreement No. W911NF-06-2-0006. The authors wish to acknowledge Steven Segletes for reviewing the manuscript, Dr. George "Rusty" Gray III (Los Alamos National Laboratory) for his valuable technical suggestions regarding the recovery experiments, Dr. Kyu Cho (ARL) and MC-21, Inc. for mechanically processing the 1100 aluminum, Dr. Brian Schuster, and Dr. Chris Meredith, and Mr. John Lidga at the U.S. Army Research Laboratory (ARL) for supporting the Electron BackScatter Diffraction work. Finally, we gratefully acknowledge the personnel at the Shock Physics Laboratory, U.S. Army Research Laboratory (Dr. Richard Becker, Mr. Stephan Bilyk, Mr. Tim Cline, and Mr. Codie Adams) for their valuable contribution which makes this work possible. NR 47 TC 4 Z9 4 U1 2 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 7 PY 2013 VL 114 IS 9 AR 093502 DI 10.1063/1.4817844 PG 11 WC Physics, Applied SC Physics GA 217UI UT WOS:000324386900009 ER PT J AU Adams, BL Finch, AS Hurley, MM Sarkes, DA Stratis-Cullum, DN AF Adams, Bryn L. Finch, Amethist S. Hurley, Margaret M. Sarkes, Deborah A. Stratis-Cullum, Dimitra N. TI Genetically Engineered Peptides for Inorganics: Study of an Unconstrained Bacterial Display Technology and Bulk Aluminum Alloy SO ADVANCED MATERIALS LA English DT Article DE peptide display; GEPI; solid-binding peptide; biomineralization; biopanning; molecular dynamics ID CELL-SURFACE DISPLAY; BINDING PEPTIDES; MOLECULAR-DYNAMICS; METAL-RECOGNITION; OXIDE BINDING; PHAGE DISPLAY; POLYPEPTIDES; ADSORPTION; SELECTION; AFFINITY C1 [Adams, Bryn L.; Finch, Amethist S.; Stratis-Cullum, Dimitra N.] US Army Res Lab, RDRL SEE B, Adelphi, MD 20783 USA. [Sarkes, Deborah A.] Goldbelt Raven LLC, Frederick, MD 21701 USA. [Hurley, Margaret M.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, RDRL SEE B, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dimitra.stratiscullum1@us.army.mil FU U.S. Army Research Laboratory Postdoctoral Fellowship Program; U.S. Army Research Laboratory FX This project is supported in part by appointments to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. Graphical artwork featured in the table of contents image and cover art feature were created by Mr. Eric Proctor at the U.S. Army Research Laboratory. The peptide sequence analysis webtool, InsertMultiSeek (www.sequencetools.com), used for batch sequence analysis was custom developed for this project by Mr. Richard Jones at Integration Dynamics, Inc. The authors also wish to thank Dr. Patrick Daugherty (UCSB) for providing the initial eCPX bacterial display library materials used in these studies and Dr. Jennifer Getz (Daugherty Lab) for useful discssions on the modifcation of the eCPX system. Additional laboratory technical support was provided by Ms. Mia Hunt at U.S. Army Research Laboratory. NR 47 TC 6 Z9 6 U1 8 U2 55 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD SEP 6 PY 2013 VL 25 IS 33 BP 4585 EP 4591 DI 10.1002/adma.201301646 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 261VM UT WOS:000327692700009 PM 23868808 ER PT J AU Reich, NG Shrestha, S King, AA Rohani, P Lessler, J Kalayanarooj, S Yoon, IK Gibbons, RV Burke, DS Cummings, DAT AF Reich, Nicholas G. Shrestha, Sourya King, Aaron A. Rohani, Pejman Lessler, Justin Kalayanarooj, Siripen Yoon, In-Kyu Gibbons, Robert V. Burke, Donald S. Cummings, Derek A. T. TI Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity SO JOURNAL OF THE ROYAL SOCIETY INTERFACE LA English DT Article DE dengue; infectious disease modelling; cross-protection; time-series models ID ANTIBODY-DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; VIRUS SEROTYPES; IMMUNOLOGICAL DETERMINANTS; CONCURRENT INFECTIONS; ACQUIRED-IMMUNITY; TRANSMISSION; BANGKOK; MODELS; NEUTRALIZATION AB Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between serotypes are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infection with dengue provides substantial short-term cross-protection against other serotypes (approx. 1-3 years). This is the first quantitative evidence that short-term cross-protection exists since human experimental infection studies performed in the 1950s. These findings will impact strategies for designing dengue vaccine studies, future multi-strain modelling efforts, and our understanding of evolutionary pressures in multi-strain disease systems. C1 [Reich, Nicholas G.] Univ Massachusetts, Div Biostat & Epidemiol, Amherst, MA 01002 USA. [Reich, Nicholas G.; Lessler, Justin; Cummings, Derek A. T.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Shrestha, Sourya; King, Aaron A.; Rohani, Pejman] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA. [Shrestha, Sourya; King, Aaron A.; Rohani, Pejman] Univ Michigan, Ctr Study Complex Syst, Ann Arbor, MI 48109 USA. [King, Aaron A.] Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA. [King, Aaron A.; Rohani, Pejman] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA. RP Reich, NG (reprint author), Univ Massachusetts, Div Biostat & Epidemiol, Amherst, MA 01002 USA. EM nick@schoolph.umass.edu RI King, Aaron/B-8092-2012; OI King, Aaron/0000-0001-6159-3207; Shrestha, Sourya/0000-0002-6106-6834; Lessler, Justin/0000-0002-9741-8109; /0000-0002-5704-8094 FU National Institute of General Medical Sciences [R01GM090204, 1U54GM088491-0109]; Bill and Melinda Gates Foundation Vaccine Modeling Initiative; RAPIDD program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health; National Oceanic and Atmospheric Administration [NA08NOS4730321] FX N.G.R., D.S.D. and D.A.T.C. were supported by the National Institute of General Medical Sciences (Award no. R01GM090204 and Award no. 1U54GM088491-0109). D.A.T.C. holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. D.A.T.C., D.S.B. and P.R. were supported by a grant from the Bill and Melinda Gates Foundation Vaccine Modeling Initiative. A.A.K. and P.R. acknowledge the support of the RAPIDD program of the Science and Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health. A.A.K. was also supported by the National Oceanic and Atmospheric Administration (grant no. NA08NOS4730321). NR 47 TC 53 Z9 53 U1 3 U2 40 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1742-5689 J9 J R SOC INTERFACE JI J. R. Soc. Interface PD SEP 6 PY 2013 VL 10 IS 86 AR 20130414 DI 10.1098/rsif.2013.0414 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 180RX UT WOS:000321614300009 PM 23825116 ER PT J AU Boncristiani, HF Evans, JD Chen, YP Pettis, J Murphy, C Lopez, DL Simone-Finstrom, M Strand, M Tarpy, DR Rueppell, O AF Boncristiani, Humberto F. Evans, Jay D. Chen, Yanping Pettis, Jeff Murphy, Charles Lopez, Dawn L. Simone-Finstrom, Michael Strand, Micheline Tarpy, David R. Rueppell, Olav TI In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera) SO PLOS ONE LA English DT Article ID COLONY COLLAPSE DISORDER; GENE-EXPRESSION; RIBOSOME BIOGENESIS; VARROA-JACOBSONI; QUANTITATIVE-PCR; RNA; APOPTOSIS; LOSSES; CELLS; POLIOVIRUS AB The ongoing decline of honey bee health worldwide is a serious economic and ecological concern. One major contributor to the decline are pathogens, including several honey bee viruses. However, information is limited on the biology of bee viruses and molecular interactions with their hosts. An experimental protocol to test these systems was developed, using injections of Israeli Acute Paralysis Virus (IAPV) into honey bee pupae reared ex-situ under laboratory conditions. The infected pupae developed pronounced but variable patterns of disease. Symptoms varied from complete cessation of development with no visual evidence of disease to rapid darkening of a part or the entire body. Considerable differences in IAPV titer dynamics were observed, suggesting significant variation in resistance to IAPV among and possibly within honey bee colonies. Thus, selective breeding for virus resistance should be possible. Gene expression analyses of three separate experiments suggest IAPV disruption of transcriptional homeostasis of several fundamental cellular functions, including an up-regulation of the ribosomal biogenesis pathway. These results provide first insights into the mechanisms of IAPV pathogenicity. They mirror a transcriptional survey of honey bees afflicted with Colony Collapse Disorder and thus support the hypothesis that viruses play a critical role in declining honey bee health. C1 [Boncristiani, Humberto F.; Rueppell, Olav] Univ N Carolina, Dept Biol, Greensboro, NC 27412 USA. [Evans, Jay D.; Chen, Yanping; Pettis, Jeff; Lopez, Dawn L.] USDA ARS, Bee Res Lab, Beltsville, MD USA. [Murphy, Charles] USDA ARS, Beltsville, MD USA. [Simone-Finstrom, Michael; Tarpy, David R.] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. [Strand, Micheline] US Army Res Off, Div Life Sci, Res Triangle Pk, NC USA. RP Boncristiani, HF (reprint author), Univ N Carolina, Dept Biol, Greensboro, NC 27412 USA. EM humbfb@gmail.com RI Rueppell, Olav/G-2679-2010; Evans, Jay/C-8408-2012 OI Rueppell, Olav/0000-0001-5370-4229; Evans, Jay/0000-0002-0036-4651 FU USDA-ARS Headquarters Postdoctoral Research Associate Program Grant; National Academy of Science; UNCG; US National Institute of Food and Agriculture AFRI grant [2010-65104-20533] FX The work was supported by the USDA-ARS Headquarters Postdoctoral Research Associate Program Grant and The National Academy of Science for the NRC fellowship grant to HFB and by UNCG and a US National Institute of Food and Agriculture AFRI grant (#2010-65104-20533) to OR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 78 TC 14 Z9 15 U1 3 U2 40 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 5 PY 2013 VL 8 IS 9 AR e73429 DI 10.1371/journal.pone.0073429 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 219CG UT WOS:000324481600076 PM 24039938 ER PT J AU Rodriguez-Fernandez, M Grosman, B Yuraszeck, TM Helwig, BG Leon, LR Doyle, FJ AF Rodriguez-Fernandez, Maria Grosman, Benyamin Yuraszeck, Theresa M. Helwig, Bryan G. Leon, Lisa R. Doyle, Francis J., III TI Modeling the Intra- and Extracellular Cytokine Signaling Pathway under Heat Stroke in the Liver SO PLOS ONE LA English DT Article ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; SHOCK TRANSCRIPTION FACTOR; ACTIVATED PROTEIN-KINASE; SYSTEMS BIOLOGY MODELS; FACTOR-I; SENSITIVITY-ANALYSIS; ACUTE-INFLAMMATION; OXIDATIVE STRESS; IL-10 PRODUCTION AB Heat stroke (HS) is a life-threatening illness induced by prolonged exposure to a hot environment that causes central nervous system abnormalities and severe hyperthermia. Current data suggest that the pathophysiological responses to heat stroke may not only be due to the immediate effects of heat exposure per se but also the result of a systemic inflammatory response syndrome (SIRS). The observation that pro- (e.g., IL-1) and anti-inflammatory (e.g., IL-10) cytokines are elevated concomitantly during recovery suggests a complex network of interactions involved in the manifestation of heat-induced SIRS. In this study, we measured a set of circulating cytokine/soluble cytokine receptor proteins and liver cytokine and receptor mRNA accumulation in wild-type and tumor necrosis factor (TNF) receptor knockout mice to assess the effect of neutralization of TNF signaling on the SIRS following HS. Using a systems approach, we developed a computational model describing dynamic changes (intra- and extracellular events) in the cytokine signaling pathways in response to HS that was fitted to novel genomic (liver mRNA accumulation) and proteomic (circulating cytokines and receptors) data using global optimization. The model allows integration of relevant biological knowledge and formulation of new hypotheses regarding the molecular mechanisms behind the complex etiology of HS that may serve as future therapeutic targets. Moreover, using our unique modeling framework, we explored cytokine signaling pathways with three in silico experiments (e.g. by simulating different heat insult scenarios and responses in cytokine knockout strains in silico). C1 [Rodriguez-Fernandez, Maria; Grosman, Benyamin; Yuraszeck, Theresa M.; Doyle, Francis J., III] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. [Rodriguez-Fernandez, Maria; Grosman, Benyamin; Yuraszeck, Theresa M.; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Helwig, Bryan G.; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA USA. RP Doyle, FJ (reprint author), Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. EM doyle@engineering.ucsb.edu RI Rodriguez-Fernandez, Maria/I-7193-2016 OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920 FU Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W911NF-09-0001, W911QY-09-P-0709] FX The authors acknowledge the financial support provided by the Institute for Collaborative Biotechnologies through grants W911NF-09-0001 and W911QY-09-P-0709 from the U.S. Army Research Office. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 95 TC 7 Z9 8 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 5 PY 2013 VL 8 IS 9 AR e73393 DI 10.1371/journal.pone.0073393 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 219CG UT WOS:000324481600071 PM 24039931 ER PT J AU Rothman, SM Herdener, N Frankola, KA Mughal, MR Mattson, MP AF Rothman, Sarah M. Herdener, Nathan Frankola, Kathryn A. Mughal, Mohamed R. Mattson, Mark P. TI Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical A beta and pTau in a mouse model of Alzheimer's disease SO BRAIN RESEARCH LA English DT Article DE Alzheimer's disease; Sleep restriction; Glucocorticoids; Amyloid; Morris water maze; Fear conditioning ID PRECURSOR PROTEIN; WATER MAZE; DEPRIVATION; NEUROGENESIS; PERFORMANCE; STRESS; COST; MICE; RAT AB Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid beta-peptide (A beta) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC). Male 3xTgAD mice were subjected to sleep restriction (SR) for 6 h/day for 6 weeks using the modified multiple platform technique, and behavioral (Morris water maze, fear conditioning, open field) and biochemical (immunoblot) outcomes were compared to mice undergoing daily cage transfers (large cage control; LCC) as well as control mice that remained in their home cage (control; CTL). At one week, both LCC and SR mice displayed significant elevations in plasma corticosterone compared to CTL (p<0.002). By four weeks, SR mice displayed a two-fold increase in circulating corticosterone levels compared to CTL. Behavioral data indicated deficits in contextual and cued memory in SR mice that were not present for LCC or CTL (p<0.04). Both A beta and pTau levels increased in the cortex of SR mice compared to CTL and LCC; however these changes were not noted in the hippocampus. Significant positive correlations between cortical A beta and pTau levels and circulating corticosterone indicate a potential role for GCs in mediating behavioral and biochemical changes observed after sleep restriction in a mouse model of AD. Published by Elsevier B.V. C1 [Rothman, Sarah M.; Herdener, Nathan; Frankola, Kathryn A.; Mughal, Mohamed R.; Mattson, Mark P.] NIA, Neurosci Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Mughal, Mohamed R.] Army Inst Publ Hlth, US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Mattson, MP (reprint author), NIA, Neurosci Lab, Intramural Res Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA. EM mark.mattson@nih.gov FU Intramural Research Program of the National Institute on Aging FX This research was supported by the Intramural Research Program of the National Institute on Aging. The authors wish to thank Ernest Dabney for assistance with retro-orbital bleeding techniques and Catherine Crews for assistance with maintenance for the in vivo portion of the study. NR 29 TC 23 Z9 23 U1 3 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD SEP 5 PY 2013 VL 1529 BP 200 EP 208 DI 10.1016/j.brainres.2013.07.010 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 221KQ UT WOS:000324658200020 PM 23856323 ER PT J AU Lee, HZ Blundell, SB Starek, MJ Harrisd, JG AF Lee, Heezin Blundell, S. Bruce Starek, Michael J. Harrisd, John G. TI Airborne lidar point cloud-based below-canopy line-of-sight visibility estimator SO JOURNAL OF APPLIED REMOTE SENSING LA English DT Article DE lidar; canopy segmentation; tree parameters; line-of-sight visibility ID FOREST CANOPY; MATURE; TREES AB Point cloud data collected by small-footprint lidar scanning systems have proven effective in modeling the forest canopy for extraction of tree parameters. Although line-of-sight visibility (LOSV) in complex forests may be important for military planning and search-and-rescue operations, the ability to estimate LOSV from lidar scanners is not well developed. A new estimator of below-canopy LOSV (BC-LOSV) by addressing the problem of estimation of lidar under-sampling of the forest understory is created. Airborne and terrestrial lidar scanning data were acquired for two forested sites in order to test a probabilistic model for BC-LOSV estimation solely from airborne lidar data. Individual crowns were segmented, and allometric projections of the probability model into the lower canopy and stem regions allowed the estimation of the likelihood of the presence of vision-blocking elements for any given LOSV vector. Using terrestrial lidar scans as ground truth, we found an approximate average absolute difference of 20% between BC-LOSV estimates from the airborne and terrestrial point clouds, with minimal bias for either over- or underestimates. The model shows the usefulness of a data-driven approach to BC-LOSV estimation that depends only on small-footprint airborne lidar point cloud and physical knowledge of tree phenology. (c) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Lee, Heezin] Univ Calif Berkeley, Natl Ctr Airborne Laser Mapping, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. [Blundell, S. Bruce] USA, ERDC Topog Engn Ctr, Alexandria, VA 22315 USA. [Starek, Michael J.] Texas A&M Univ Corpus Christi, Harte Res Inst Gulf Mexico Studies, Corpus Christi, TX 78412 USA. [Harrisd, John G.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. RP Lee, HZ (reprint author), Univ Calif Berkeley, Natl Ctr Airborne Laser Mapping, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. EM heezin.lee@berkeley.edu FU US Army Research Office (ARO) [W911NF-06-1-0459] FX This work was supported by the US Army Research Office (ARO) under Grant W911NF-06-1-0459. The authors would like to thank Dr. Ahmed Mohamed, Adam Benjamin, and Dr. Ben Wilkinson at the University of Florida for providing facilities and support during the collection of terrestrial lidar data. NR 15 TC 1 Z9 1 U1 3 U2 26 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1931-3195 J9 J APPL REMOTE SENS JI J. Appl. Remote Sens. PD SEP 5 PY 2013 VL 7 AR 073510 DI 10.1117/1.JRS.7.073510 PG 7 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 211QB UT WOS:000323923200001 ER PT J AU Sanghavi, BJ Sitaula, S Griep, MH Karna, SP Ali, MF Swami, NS AF Sanghavi, Bankim J. Sitaula, Sarita Griep, Mark H. Karna, Shashi P. Ali, Mehnaaz F. Swami, Nathan S. TI Real-Time Electrochemical Monitoring of Adenosine Triphosphate in the Picomolar to Micromolar Range Using Graphene-Modified Electrodes SO ANALYTICAL CHEMISTRY LA English DT Article ID CARBON-PASTE ELECTRODE; POTENTIOMETRIC STRIPPING ANALYSIS; COPPER(II) COMPLEX; BIOMIMETIC SENSOR; MAGNETIC BEADS; NUCLEIC-ACIDS; ATP DETECTION; DNA; HYBRIDIZATION; BIOSENSORS AB We report on a competitive electrochemical detection system that is free of wash steps and enables the real-time monitoring of adenosine triphosphate (ATP) in a quantitative manner over a five-log concentration range. The system utilizes a recognition surface based on ATP aptamer (ATPA) capture probes prebound to electroactive flavin adenine dinucleotide (FAD) molecules, and a signaling surface utilizing graphene (Gr) and gold nanoparticle (AuNP) modified carbon paste electrode (Gr-AuNP-CPE) that is optimized to enhance electron-transfer kinetics and signal sensitivity. Binding of ATP to ATPA at the recognition surface causes the release of an equivalent concentration of FAD that can be quantitatively monitored in real time at the signaling surface, thereby enabling a wide linear working range (1.14 X 10(-10) to 3.0 x 10(-5) M), a low detection limit (2.01 x 10(-11) M using graphene and AuNP modified glassy carbon), and fast target binding kinetics (steady-state signal within 12 min at detection limit). Unlike assays based on capture probe-immobilized electrodes, this double-surface competitive assay offers the ability to speed up target binding kinetics by increasing the capture probe concentration, with no limitations due to intermolecular Coulombic interactions and nonspecific binding. We utilize the real-time monitoring capability to compute kinetic parameters for target binding and to make quantitative distinctions on degree of base-pair mismatch through monitoring target binding kinetics over a wide concentration range. On the basis of the simplicity of the assay chemistry and the quantitative detection of ATP within fruit and serum media, as demonstrated by comparison of ATP levels against those determined using a standard high-performance liquid chromatography (HPLC)-UV absorbance method, we envision a versatile detection platform for applications requiring real-time monitoring over a wide target concentration range. C1 [Sanghavi, Bankim J.; Swami, Nathan S.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Sitaula, Sarita; Ali, Mehnaaz F.] Xavier Univ Louisiana, Dept Chem, New Orleans, LA 70125 USA. [Griep, Mark H.; Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Swami, NS (reprint author), Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. EM nswami@virginia.edu FU Asian Office Aerospace Research and Development [114083]; LCRC; NIH-RCMI [8G12MD007595-04]; RCSA Cottrell College Science Program; NSF PREM [DMR-0934111] FX N.S.S. acknowledges support from the Asian Office Aerospace Research and Development (Grant No. 114083). M.F.A. is supported by the LCRC and the NIH-RCMI Grant No. 8G12MD007595-04 and by the RCSA Cottrell College Science Program. S.S. is supported by the NSF PREM (award no. DMR-0934111). NR 50 TC 129 Z9 129 U1 14 U2 156 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD SEP 3 PY 2013 VL 85 IS 17 BP 8158 EP 8165 DI 10.1021/ac4011205 PG 8 WC Chemistry, Analytical SC Chemistry GA 294BL UT WOS:000330017300021 PM 23875581 ER PT J AU Hutchison, JM Poust, SK Kumar, M Cropek, DM MacAllister, IE Arnett, CM Zilles, JL AF Hutchison, Justin M. Poust, Sean K. Kumar, Manish Cropek, Donald M. MacAllister, Irene E. Arnett, Clint M. Zilles, Julie L. TI Perchlorate Reduction Using Free and Encapsulated Azospira oryzae Enzymes SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID CONTAMINATED DRINKING-WATER; ION-EXCHANGE; BIOLOGICAL TREATMENT; ESCHERICHIA-COLI; STRAIN GR-1; NITRATE; REMOVAL; PROTEIN; TECHNOLOGIES; MEMBRANES AB Existing methods for perchlorate remediation are hampered by the common co-occurrence of nitrate, which is structurally similar and a preferred electron acceptor. In this work, the potential for perchlorate removal using cell-free bacterial enzymes as biocatalysts was investigated using crude cell lysates and soluble protein fractions of Azospira oryzae PS, as well as soluble protein fractions encapsulated in lipid and polymer vesicles. The crude lysates showed activities between 41 700 to 54 400 U L-1 (2.49 to 3.06 U mg(-1) total protein). Soluble protein fractions had activities of 15 400 to 29 900 U L-1 (1.70 to 1.97 U mg(-1)) and still retained an average of 58.2% of their original activity after 23 days of storage at 4 degrees C under aerobic conditions. Perchlorate was removed by the soluble protein fraction at higher rates than nitrate. Importantly, perchlorate reduction occurred even in the presence of 500-fold excess nitrate. The soluble protein fraction retained its function after encapsulation in lipid or polymer vesicles, with activities of 13.8 to 70.7 U L-1, in agreement with theoretical calculations accounting for the volume limitation of the vesicles. Further, encapsulation mitigated enzyme inactivation by proteinase K. Enzyme-based technologies could prove effective at perchlorate removal from water cocontaminated with nitrate or sulfate. C1 [Hutchison, Justin M.; Poust, Sean K.; Kumar, Manish; Zilles, Julie L.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Cropek, Donald M.; MacAllister, Irene E.; Arnett, Clint M.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Zilles, JL (reprint author), 3230C Newmark Civil Engn Lab, MC250,205 North Mathews Ave, Urbana, IL 61801 USA. EM jzilles@illinois.edu RI Kumar, Manish/C-2346-2008; OI Poust, Sean/0000-0003-1703-2992; Zilles, Julie/0000-0001-8684-4519 FU United States Army Corps of Engineer Basic Research Program; U.S. National Science Foundation [CBET 08-28512] FX We thank Dr. Mariusz Grzelakowski and Professor Wolfgang Meier (University of Basel, Switzerland) for the PMOX-A:PDMS:PMOXA polymer and strain BL21(DE3) omp8 and anonymous reviewers for constructive comments. Support for this research was provided by The United States Army Corps of Engineer Basic Research Program and the U.S. National Science Foundation (CBET 08-28512). NR 58 TC 4 Z9 6 U1 5 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 3 PY 2013 VL 47 IS 17 BP 9934 EP 9941 DI 10.1021/es402081b PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 295CR UT WOS:000330094700048 PM 23924304 ER PT J AU Hashimoto, S Matsuura, T Nanko, K Linkov, I Shaw, G Kaneko, S AF Hashimoto, Shoji Matsuura, Toshiya Nanko, Kazuki Linkov, Igor Shaw, George Kaneko, Shinji TI Predicted spatio-temporal dynamics of radiocesium deposited onto forests following the Fukushima nuclear accident SO SCIENTIFIC REPORTS LA English DT Article ID CHERNOBYL ACCIDENT; RADIOACTIVE CONTAMINATION; LONG-TERM; ECOSYSTEMS; COUNTERMEASURES; RADIONUCLIDES; TREES; JAPAN; SOILS; WOOD AB The majority of the area contaminated by the Fukushima Dai-ichi nuclear power plant accident is covered by forest. To facilitate effective countermeasure strategies to mitigate forest contamination, we simulated the spatio-temporal dynamics of radiocesium deposited into Japanese forest ecosystems in 2011 using a model that was developed after the Chernobyl accident in 1986. The simulation revealed that the radiocesium inventories in tree and soil surface organic layer components drop rapidly during the first two years after the fallout. Over a period of one to two years, the radiocesium is predicted to move from the tree and surface organic soil to the mineral soil, which eventually becomes the largest radiocesium reservoir within forest ecosystems. Although the uncertainty of our simulations should be considered, the results provide a basis for understanding and anticipating the future dynamics of radiocesium in Japanese forests following the Fukushima accident. C1 [Hashimoto, Shoji; Nanko, Kazuki; Kaneko, Shinji] FFPRI, Dept Forest Site Environm, Tsukuba, Ibaraki 3058687, Japan. [Matsuura, Toshiya] FFPRI, Dept Forest Management, Tsukuba, Ibaraki 3058687, Japan. [Linkov, Igor] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Shaw, George] Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, Leics, England. RP Hashimoto, S (reprint author), FFPRI, Dept Forest Site Environm, 1 Matsunosato, Tsukuba, Ibaraki 3058687, Japan. EM shojih@ffpri.affrc.go.jp RI Nanko, Kazuki/F-4833-2010; Hashimoto, Shoji/C-5785-2011 OI Nanko, Kazuki/0000-0002-1157-9287; Hashimoto, Shoji/0000-0003-3022-7495 FU FFPRI FX The study was supported by FFPRI. NR 29 TC 25 Z9 26 U1 3 U2 40 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD SEP 2 PY 2013 VL 3 AR 2564 DI 10.1038/srep02564 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 209CZ UT WOS:000323733100002 PM 23995073 ER PT J AU Smith, R AF Smith, Roger TI The Rainbow Zebra SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Article C1 [Smith, Roger] US Army Simulat, Orlando, FL USA. [Smith, Roger] Titan Corp, San Diego, CA USA. [Smith, Roger] BTG Inc, Jacksonville, FL USA. EM roger.smith@flhosp.org NR 0 TC 0 Z9 0 U1 0 U2 3 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD SEP-OCT PY 2013 VL 56 IS 5 BP 60 EP 61 DI 10.5437/08956308X5605009 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA AI8XT UT WOS:000337211000013 ER PT J AU Niece, KL Vaughan, AD Devore, DI AF Niece, Krista L. Vaughan, Asa D. Devore, David I. TI Graft copolymer polyelectrolyte complexes for delivery of cationic antimicrobial peptides SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE graft copolymers; poly(alkylacrylic acid); cationic antimicrobial peptides; polyelectrolyte complexes; human plasma degradation ID DRUG-DELIVERY; BACTERIAL-INFECTIONS; BIOFILM FORMATION; NANOPARTICLES; POLYMERS; SYSTEMS; PROTEIN; RESISTANCE; LIPOSOMES; RELEASE AB Peptides have enormous potential as therapeutic agents for the treatment of infection, in immunomodulation and for other medical applications, but their hydrolytic degradation in biological fluids is a serious limitation to their in vivo performance. Here we demonstrate the potential utility of polyelectrolyte nanoparticle complexes of novel self-assembling anionic graft copolymers for protecting peptides from degradation in human plasma. The anionic graft copolymers are synthesized by covalently attaching pendent polyetheramine chains to poly(alkylacrylic acid) backbones by carbodiimide coupling. The peptide:copolymer nanocomplexes' particle size, zeta-potential, peptide binding, and controlled release of the peptide are shown to be dependent upon the pendent chain graft density, polymer backbone alkyl groups (propyl vs. methyl), and the nanocomplexes' electrostatic charge ratio. The nanocomplexes can provide substantial protection to the bound peptides from degradation in human plasma for at least 24 h and, in standard microbiological assays are shown to retain some or all of the peptide's antimicrobial activity against a clinically relevant strain of Staphylococcus aureus. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2548-2558, 2013. C1 [Niece, Krista L.; Vaughan, Asa D.; Devore, David I.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Devore, DI (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM david.devore@us.army.mil FU Department of Defense FY10 Defense Medical Research; Development Program (DMRDP); Military Infectious Diseases Research Program Basic Research Award [D61_I_10_J2_235] FX Contract grant sponsor: Department of Defense FY10 Defense Medical Research; Contract grant sponsor: Development Program (DMRDP); Contract grant sponsor: Military Infectious Diseases Research Program Basic Research Award; contract grant number: D61_I_10_J2_235 NR 46 TC 6 Z9 6 U1 2 U2 38 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1549-3296 EI 1552-4965 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD SEP PY 2013 VL 101 IS 9 BP 2548 EP 2558 DI 10.1002/jbm.a.34555 PG 11 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 186RN UT WOS:000322061900011 PM 23364909 ER PT J AU Waterman, PE McGann, P Snesrud, E Clifford, RJ Kwak, YI Munoz-Urbizo, IP Tabora-Castellanos, J Milillo, M Preston, L Aviles, R Sutter, DE Lesho, EP AF Waterman, Paige E. McGann, Patrick Snesrud, Erik Clifford, Robert J. Kwak, Yoon I. Munoz-Urbizo, Ivon P. Tabora-Castellanos, Juana Milillo, Michael Preston, Lan Aviles, Ricardo Sutter, Deena E. Lesho, Emil P. TI Bacterial Peritonitis Due to Acinetobacter baumannii Sequence Type 25 with Plasmid-Borne New Delhi Metallo-beta-Lactamase in Honduras SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID KLEBSIELLA-PNEUMONIAE; GENOME SEQUENCE; RESISTANCE; ENTEROBACTERIACEAE; SURVEILLANCE; INSIGHTS; CARBAPENEMASES; EPIDEMIOLOGY; BLA(NDM-1); NDM AB A carbapenem-resistant Acinetobacter baumannii strain was isolated from the peritoneal fluid of a patient with complicated intra-abdominal infection and evaluated at the Multidrug-resistant Organism Repository and Surveillance Network by whole-genome sequencing and real-time PCR. The isolate was sequence type 25 and susceptible to colistin and minocycline, with low MICs of tigecycline. bla(NDM-1) was located on a plasmid with > 99% homology to pNDM-BJ02. The isolate carried numerous other antibiotic resistance genes, including the 16S methylase gene, armA. C1 [Waterman, Paige E.; McGann, Patrick; Snesrud, Erik; Clifford, Robert J.; Kwak, Yoon I.; Milillo, Michael; Preston, Lan; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Munoz-Urbizo, Ivon P.; Tabora-Castellanos, Juana] Hosp Escuela Tegucigalpa, Dept Epidemiol, Tegucigalpa, Honduras. [Aviles, Ricardo] Joint Task Force Bravo, Med Element, Soto Cano Air Base, Honduras. [Sutter, Deena E.] San Antonio Mil Med Ctr, Div Pediat Infect Dis, Ft Sam Houston, TX USA. RP Waterman, PE (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM paige.e.waterman.mil@mail.mil; patrick.t.mcgann4.ctr@mail.mil FU U.S. Army Medical Command (MEDCOM); Department of Defense Global Emerging Infections Surveillance and Response System (GEIS) FX Major funding for this study was provided by the U.S. Army Medical Command (MEDCOM) and the Department of Defense Global Emerging Infections Surveillance and Response System (GEIS). We gratefully acknowledge the support of Guy Lemire and Bart Diaz at the Joint Task Force-Bravo, Soto Cano Air Base, Honduras. We also gratefully acknowledge the support and assistance of Douglas Lougee, a surgeon with the U.S. Southern Command (USSOUTHCOM). We thank Blanca Hernandez and Fanny Hidalgo, Facultad de Microbiologia, Universidad Nacional Autonoma de Honduras, for isolate collection and transport. NR 26 TC 11 Z9 11 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2013 VL 57 IS 9 BP 4584 EP 4586 DI 10.1128/AAC.00275-13 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AH7IW UT WOS:000336307700002 PM 23817381 ER PT J AU Van Sickle, C Schafer, K Mulligan, J Grudic, GZ Moulton, SL Convertino, VA AF Van Sickle, Christina Schafer, Kristin Mulligan, Jane Grudic, Gregory Z. Moulton, Steven L. Convertino, Victor A. TI A Sensitive Shock Index for Real-Time Patient Assessment During Simulated Hemorrhage SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE central hypovolemia; lower body negative pressure; stroke volume; pulse pressure; blood pressure; medical monitoring ID BODY NEGATIVE-PRESSURE; MASSIVE TRANSFUSION; COMBAT CASUALTIES; IDENTIFYING RISK; TRAUMA PATIENTS; VITAL SIGNS; HEART-RATE; BLOOD; UTILITY; HYPOVOLEMIA AB Background: Shock index [SI = the ratio of heart rate (HR) to systolic arterial pressure (SAP)] is a metric used to diagnose patients at risk of impending hemorrhagic shock. We hypothesized that a metric called the compensatory reserve index (CRI), derived using computer modeling with continuous feature extraction from arterial waveforms, would provide an earlier indicator of cardiovascular instability than SI during progressive central hypovolemia. Methods: There were 15 subjects (men = 8; women = 7) who underwent progressive reduction in central blood volume induced by lower body negative pressure (LBNP) until SAP < 90 mmHg. CRI was normalized on a scale of 1 (normovolemia) to 0 (circulatory volume at which instability occurs) and displayed on a colored bar. The times at which the CRI equaled 0.6 (threshold of green to amber) or 0.3 (threshold of amber to red) were compared to a clinical threshold of SI >= 0.9. Results: A SI >= 0.9 required 22.4 +/- 6.2 min (95%CI = 19 to 25.8 min). CRI reached 0.6 (amber) at 12.5 +/- 4.9 min (95%CI = 9.8 to 15.3 min) when SI = 0.61 +/- 0.03, and became 0.3 (red) at 20.3 +/- 5.1 min (95%CI = 17.5 to 23.1 min) when SI = 0.81 +/- 1.4. Conclusions: CRI provided a significantly earlier indicator of impending hemodynamic decompensation than SI 0.9 during progressive LBNP. These results support the notion that the CRI represents an improved 'shock index' as an indicator of impending hemorrhagic shock compared to standard vital signs. C1 [Van Sickle, Christina] Smithson Valley High Sch, San Antonio, TX USA. [Schafer, Kristin] United Negro Coll Fund, Fairfax, VA USA. [Mulligan, Jane; Grudic, Gregory Z.] Flashback Technol Inc, Boulder, CO USA. [Moulton, Steven L.] Univ Colorado, Sch Med, Dept Surg, Aurora, CO USA. [Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU U.S. Army Medical Research and Materiel Command Combat Casualty Research Program FX This study was conducted under a protocol reviewed and approved by the Institutional Review Board, Office of Research Protection, Medical Research and Materiel Command, and in accordance with the approved protocol. Funding support was provided by the U.S. Army Medical Research and Materiel Command Combat Casualty Research Program. Drs. Grudic and Mulligan are developers of the CRI model used in this study. Dr. Moulton is a co-founder and medical consultant to Flashback Technologies, Inc. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 30 TC 11 Z9 11 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2013 VL 84 IS 9 BP 907 EP 912 DI 10.3357/ASEM.3606.2013 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AD1LV UT WOS:000332996400001 PM 24024301 ER PT J AU Venghaus, JL AF Venghaus, Jennifer L. TI SEVEN YEARS LATER: THE STRUGGLE WITH MORENO CONTINUES SO MILITARY LAW REVIEW LA English DT Article C1 [Venghaus, Jennifer L.] US Army, Off Judge Advocate Gen, Washington, DC USA. RP Venghaus, JL (reprint author), US Army, Washington, DC 20310 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2013 VL 217 BP 1 EP 47 PG 47 WC Law SC Government & Law GA AC2QO UT WOS:000332349200001 ER PT J AU Cusack, C AF Cusack, Colin TI WE'VE TALKED THE TALK, TIME TO WALK THE WALK: MEETING INTERNATIONAL HUMAN RIGHTS LAW STANDARDS FOR US MILITARY INVESTIGATIONS SO MILITARY LAW REVIEW LA English DT Article C1 [Cusack, Colin] US Army, Washington, DC 20310 USA. [Cusack, Colin] Off Judge Advocate Gen, Adm Law Div, Washington, DC USA. RP Cusack, C (reprint author), US Army, Washington, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2013 VL 217 BP 48 EP 90 PG 43 WC Law SC Government & Law GA AC2QO UT WOS:000332349200002 ER PT J AU Alcala, RTP AF Alcala, Ronald T. P. TI REVOLUTIONARY SUMMER: THE BIRTH OF AMERICAN INDEPENDENCE SO MILITARY LAW REVIEW LA English DT Book Review C1 [Alcala, Ronald T. P.] US Army, Washington, DC 20310 USA. [Alcala, Ronald T. P.] US Army, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. RP Alcala, RTP (reprint author), US Army, Washington, DC 20310 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2013 VL 217 BP 234 EP 241 PG 8 WC Law SC Government & Law GA AC2QO UT WOS:000332349200009 ER PT J AU Kagawa, T AF Kagawa, Takashi TI THE RED CIRCLE: MY LIFE IN THE NAVY SEAL SNIPER CORPS AND HOW I TRAINED AMERICA'S DEADLIEST MARKSMEN SO MILITARY LAW REVIEW LA English DT Book Review C1 [Kagawa, Takashi] US Army, Washington, DC 20310 USA. US Army, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 62, Charlottesville, VA USA. RP Kagawa, T (reprint author), US Army, Washington, DC 20310 USA. NR 19 TC 0 Z9 0 U1 1 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2013 VL 217 BP 242 EP 250 PG 9 WC Law SC Government & Law GA AC2QO UT WOS:000332349200010 ER PT J AU O'Connell, RJ Excler, JL AF O'Connell, Robert J. Excler, Jean-Louis TI HIV Vaccine Efficacy and Immune Correlates of Risk SO CURRENT HIV RESEARCH LA English DT Article DE Efficacy trial; immune correlates; HIV; prime-boost; V2 antibodies; vaccine ID T-CELL RESPONSES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; NEUTRALIZING ANTIBODY-RESPONSE; ADENOVIRUS SEROTYPE 5; PHASE-III HIV; IMMUNODEFICIENCY-VIRUS; RHESUS-MONKEYS; FC-RECEPTOR; OF-CONCEPT; ANTIRETROVIRAL THERAPY AB Although immune correlates of protection for HIV vaccines have remained an intractable question, RV144 provided the first evidence that an HIV vaccine could provide protective efficacy against HIV acquisition. The study of correlates of risk has opened large and unforeseen avenues of exploration and hope for the most exciting time of HIV vaccine development. Several elements in the RV144 post-hoc analysis and recent macaque challenge studies suggest that antibodies directed against the V2 loop of gp120 are functional and may have played a protective role against virus acquisition. Several protective mechanisms against sexual transmission of HIV are evoked including blocking the gp120-alpha 4 beta 7 interaction and ADCC although possibly mitigated by high levels of Env-specific IgA, both mechanisms contributing at least partially to the protective effect. Several questions remain unanswered that will deserve intensive assessments, in particular, IgG and IgA Env antibodies in mucosal secretions, Env-specific IgG subclasses, cross-reaction of V2 antibodies, role of T-follicular helper cells, and B-cell memory. Whether RV144 correlates of risk are universal and apply at least partially to other populations at higher risk for HIV acquisition and other modes of transmission (rectal, injecting drug users) is unknown and remains to be explored. Future efficacy trials using the same vaccine concept tested in high-risk heterosexual populations and in men having sex with men may answer this question. In addition, the determination of early events in the pathogenesis among HIV-infected vaccine recipients based on current correlates knowledge would offer unprecedented information about correlates biomarkers in the peripheral blood and gut mucosa during early acute HIV infection. C1 [O'Connell, Robert J.] Armed Forces Inst Med Sci AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. [Excler, Jean-Louis] US Mil HIV Res Program MHRP, Henry M Jackson Fdn Adv Mil Med Vaccine Clin Dev, Bethesda, MD 20817 USA. RP Excler, JL (reprint author), US Mil HIV Res Program MHRP, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org NR 138 TC 7 Z9 7 U1 2 U2 6 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1570-162X EI 1873-4251 J9 CURR HIV RES JI Curr. HIV Res. PD SEP PY 2013 VL 11 IS 6 BP 450 EP 463 PG 14 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AB6DT UT WOS:000331878500003 PM 24033301 ER PT J AU Hennessy, C Barry, BE AF Hennessy, Colin Barry, Brock E. TI The Civil War Battle of the Crater: An Engineering Inspiration SO CIVIL ENGINEERING LA English DT Article C1 [Hennessy, Colin] US Army, Infantry Branch, Adelphi, MD 20783 USA. [Barry, Brock E.] US Mil Acad, Civil & Mech Engn Dept, West Point, NY USA. RP Hennessy, C (reprint author), US Army, Infantry Branch, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD SEP PY 2013 VL 83 IS 9 BP 61 EP 66 PG 6 WC Engineering, Civil SC Engineering GA 303LL UT WOS:000330675600015 ER PT J AU Hunsberger, LE Barry, BE AF Hunsberger, Louis E. Barry, Brock E. TI World War I Trench Warfare: Geotechnical Considerations SO CIVIL ENGINEERING LA English DT Article C1 [Hunsberger, Louis E.] US Army, Engineer Branch, Adelphi, MD 20783 USA. [Barry, Brock E.] US Mil Acad, Civil & Mech Engn Dept, West Point, NY USA. RP Hunsberger, LE (reprint author), US Army, Engineer Branch, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD SEP PY 2013 VL 83 IS 9 BP 67 EP 70 PG 4 WC Engineering, Civil SC Engineering GA 303LL UT WOS:000330675600016 ER PT J AU Downey, R Barry, BE AF Downey, Robert Barry, Brock E. TI The Battle for Iwo Jima: How Soil Mechanics Can Influence History SO CIVIL ENGINEERING LA English DT Article C1 [Downey, Robert] US Army, Infantry Branch, Adelphi, MD 20783 USA. [Barry, Brock E.] US Mil Acad, Civil & Mech Engn Dept, West Point, NY USA. RP Downey, R (reprint author), US Army, Infantry Branch, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD SEP PY 2013 VL 83 IS 9 BP 71 EP 77 PG 7 WC Engineering, Civil SC Engineering GA 303LL UT WOS:000330675600017 ER PT J AU Brunye, TT Howe, JL Walker, LA Mahoney, CR AF Brunye, Tad T. Howe, Jessica L. Walker, Leila A. Mahoney, Caroline R. TI Acute bouts of endurance exercise increase distractibility to emotional stimuli SO INTERNATIONAL JOURNAL OF SPORT PSYCHOLOGY LA English DT Article DE Arousal; Emotion Exercise; Executive functions; Physical fitness; Prefrontal cortex ID HIGH-INTENSITY EXERCISE; SPATIAL WORKING-MEMORY; ACUTE AEROBIC EXERCISE; PHYSICAL-EXERCISE; COGNITIVE PERFORMANCE; TRANSIENT HYPOFRONTALITY; INCREMENTAL EXERCISE; SUBMAXIMAL EXERCISE; RESISTANCE EXERCISE; PERCEIVED EXERTION AB OBJECTIVES: Some current neurocognitive models suggest that physical exertion selectively impairs performance of cognitive tasks demanding engagement of the prefrontal cortex. The present study tested this hypothesis by examining the effects of an acute bout of physical exertion on a prefrontal-dependent task demanding the effortful control of attention and emotion. Design: In a repeated-measures design, participants pedaled a recumbent bicycle ergometer at either a low or high work rate corresponding to percentages (25-35% or 75-85%) of maximum heart rate achieved during a peak exercise test. METHOD: To challenge cognitive processes dependent on regions of the brain's prefrontal cortex, participants performed a cognitive interference task that presented either neutral or emotionally distracting images embedded within a spatial working memory task. RESULTS: Working memory decrements on trials with embedded negative versus neutral images; importantly, this effect was exacerbated in the high versus low work rate. This exercise-induced decrement did not maintain during cool-down or rest, and was predicted by participant fitness levels. By comparison, a relatively low-level perceptuo-motor reaction time task showed faster performance during the high versus low work rate. CONCLUSIONS: Acute bouts of submaximal exercise induce transient states of reduced effortful control of attention, resulting in heightened distractability to emotional stimuli. Results are discussed with regard to theories detailing dynamic interactions between brain networks mediating physical exertion and higher-level cognitive function. C1 [Brunye, Tad T.; Howe, Jessica L.; Mahoney, Caroline R.] US Army Natick Soldier RDEC, Cognit Sci Team, Natick, MA USA. [Brunye, Tad T.; Mahoney, Caroline R.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Walker, Leila A.] US Army Res Inst Environm Med, Natick, MA USA. RP Brunye, TT (reprint author), US Army NSRDEC, RDNS WSH S, Natick, MA 01760 USA. EM tbruny01@tufts.edu NR 64 TC 0 Z9 0 U1 7 U2 21 PU EDIZIONI LUIGI POZZI PI ROME PA VIA PANAMA 68, 00198 ROME, ITALY SN 0047-0767 J9 INT J SPORT PSYCHOL JI Int. J. Sport Psychol. PD SEP-OCT PY 2013 VL 44 IS 5 BP 471 EP 492 DI 10.7352/IJSP2013.44.471 PG 22 WC Hospitality, Leisure, Sport & Tourism; Psychology; Psychology, Multidisciplinary; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 304LZ UT WOS:000330749700005 ER PT J AU Faulk, TI Hill, EM Griffith, ME Battafarano, DF Morris, MJ AF Faulk, Tarra I. Hill, Erica M. Griffith, Matthew E. Battafarano, Daniel F. Morris, Michael J. TI Rheumatoid Arthritis and Tracheal Chondritis Complicated by Pulmonary Nontuberculous Mycobacteria Infection SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article ID RELAPSING POLYCHONDRITIS; MANIFESTATIONS C1 [Faulk, Tarra I.] Brooke Army Med Ctr, Dept Internal Med, Ft Sam Houston, TX 78234 USA. [Hill, Erica M.; Battafarano, Daniel F.] Brooke Army Med Ctr, Rheumatol Serv, Ft Sam Houston, TX 78234 USA. [Griffith, Matthew E.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Sam Houston, TX 78234 USA. RP Faulk, TI (reprint author), Dept Internal Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM tarra.i.faulk.mil@mail.mil NR 12 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 EI 1536-7355 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD SEP PY 2013 VL 19 IS 6 BP 353 EP 355 DI 10.1097/RHU.0b013e31829cf5ce PG 3 WC Rheumatology SC Rheumatology GA 300KC UT WOS:000330461800012 PM 23965476 ER PT J AU Brenner, ML Moore, LJ DuBose, JJ Tyson, GH McNutt, MK Albarado, RP Holcomb, JB Scalea, TM Rasmussen, TE AF Brenner, Megan L. Moore, Laura J. DuBose, Joseph J. Tyson, George H. McNutt, Michelle K. Albarado, Rondel P. Holcomb, John B. Scalea, Thomas M. Rasmussen, Todd E. TI A clinical series of resuscitative endovascular balloon occlusion of the aorta for hemorrhage control and resuscitation SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Trauma; hemorrhagic shock; endovascular surgery; resuscitation; balloon aortic occlusion ID OPERATION-ENDURING-FREEDOM; TRAUMATIC VASCULAR INJURY; ANEURYSM REPAIR; CHANGING LANDSCAPE; IRAQI-FREEDOM; EVOLVING ROLE; SHOCK; DEATH; MODEL; THORACOTOMY AB BACKGROUND: A requirement for improved methods of hemorrhage control and resuscitation along with the translation of endovascular specialty skills has resulted in reappraisal of resuscitative endovascular balloon occlusion of the aorta (REBOA) for end-stage shock. The objective of this report was to describe implementation of REBOA in civilian trauma centers. METHODS: Descriptive case series of REBOA (December 2012 to March 2013) used in scenarios of end-stage hemorrhagic shock at the University of Maryland, R. Adams Cowley Shock Trauma Center, Baltimore, Maryland, and Herman Memorial Hospital, The Texas Trauma Institute, Houston, Texas. RESULTS: REBOA was performed by trauma and acute care surgeons for blunt (n = 4) and penetrating (n = 2) mechanisms. Three cases were REBOA in the descending thoracic aorta (Zone I) and three in the infrarenal aorta (Zone III). Mean (SD) systolic blood pressure at the time of REBOA was 59 (27) mm Hg, and mean (SD) base deficit was 13 (5). Arterial access was accomplished using both direct cutdown (n = 3) and percutaneous (n = 3) access to the common femoral artery. REBOA resulted in a mean (SD) increase in blood pressure of 55 (20) mm Hg, and the mean (SD) aortic occlusion time was 18 (34) minutes. There were no REBOA-related complications, and there was no hemorrhage-related mortality. CONCLUSION: REBOA is a feasible and effective means of proactive aortic control for patients in end-stage shock from blunt and penetrating mechanisms. With available technology, this method of resuscitation can be performed by trauma and acute care surgeons who have benefited from instruction on a limited endovascular skill set. Future work should be aimed at devices that allow easy, fluoroscopy-free access and studies to define patients most likely to benefit from this procedure. (Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Brenner, Megan L.; DuBose, Joseph J.; Scalea, Thomas M.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [DuBose, Joseph J.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Baltimore, MD USA. [Moore, Laura J.; Tyson, George H.; McNutt, Michelle K.; Albarado, Rondel P.; Holcomb, John B.] Univ Texas Houston, Texas Trauma Inst, Houston, TX USA. [Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. RP Rasmussen, TE (reprint author), US Army Inst Surg Res, Joint Base Ft Sam Housto, TX USA. EM todd.e.rasmussen.mil@mail.mil NR 34 TC 93 Z9 95 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2013 VL 75 IS 3 BP 506 EP 511 DI 10.1097/TA.0b013e31829e5416 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300GZ UT WOS:000330453700024 PM 24089121 ER PT J AU Freeman, JJ Storto, DLP Berry-Caban, CS AF Freeman, Julie J. Storto, Dominic L. P. Berry-Caban, Cristobal S. TI Repair of a Vesicocutaneous Fistula Using Negative-Pressure Wound Therapy and Urinary Diversion via a Nephrostomy Tube SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING LA English DT Article DE Bladder; Fistula; Negative pressure wound therapy; Vesicocutaneous fistula AB BACKGROUND: This article describes an unusual case of a vesicocutaneous fistula in a patient with a history of radiation therapy and recent abdominal surgery. CASE: A 61-year-old woman was transferred to our acute care facility from a rehabilitation facility, with poor nutritional intake and a concern for urine draining from her wound. A nephrostomy tube was placed (she had only 1 functioning kidney) and negative-pressure wound therapy was used to close the fistula. CONCLUSION: Urinary diversion via a nephrostomy tube and negative-pressure wound therapy were used to successfully and safely close this vesicocutaneous fistula. C1 [Freeman, Julie J.] Womack Army Med Ctr, Dept Nursing, Ft Bragg, NC USA. [Storto, Dominic L. P.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA. [Berry-Caban, Cristobal S.] Womack Army Med Ctr, Dept Res, Ft Bragg, NC USA. RP Freeman, JJ (reprint author), 2209 Goldentree Way, Vienna, VA 22182 USA. EM Julie.jacob.freeman@gmail.com NR 17 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1071-5754 EI 1528-3976 J9 J WOUND OSTOMY CONT JI J. Wound Ostomy Cont. Nurs. PD SEP-OCT PY 2013 VL 40 IS 5 BP 536 EP 538 DI 10.1097/WON.0b013e3182a46549 PG 3 WC Nursing SC Nursing GA 300KA UT WOS:000330461600014 PM 24448623 ER PT J AU Hart, EC Charkoudian, N Joyner, MJ Barnes, JN Curry, TB Casey, DP AF Hart, Emma C. Charkoudian, Nisha Joyner, Michael J. Barnes, Jill N. Curry, Timothy B. Casey, Darren P. TI Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY LA English DT Article DE Aortic pressure; Sympathetic nerve activity; Menopause; Women; Pressure wave reflection ID ARTERIAL-PRESSURE REGULATION; AGE-RELATED-CHANGES; TOTAL BLOOD-VOLUME; CARDIAC-OUTPUT; CARDIOVASCULAR EVENTS; AUGMENTATION INDEX; VASCULAR-DISEASE; STROKE VOLUME; HEALTHY-MEN; GENDER AB Objective: Aortic wave reflection characteristics, such as augmentation index, are positively related to muscle sympathetic nerve activity in young men. In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal women. Methods: Muscle sympathetic nerve activity (peroneal microneurography) and arterial pressure (brachial catheter) were measured in 16 postmenopausal women (mean [SEM] age, 60 [2] y). Aortic blood pressure and wave form characteristics were synthesized from radial arterial pressure waves (applanation tonometry). Specifically, augmentation index, wave reflection amplitude, and estimated wasted left ventricular energy were calculated. These data were compared with our previously published work from an identical protocol in 23 young women (mean [SEM] age, 25 [1] y). Results: Tonic sympathetic activity was higher in postmenopausal women than in young women (64 [3] vs 24 [4] bursts/100 heartbeats). All indices of aortic wave reflection were higher in postmenopausal women than in young women (P < 0.05). Baseline sympathetic activity was inversely related to augmentation index (r = -0.63, P < 0.05), augmented pressure (r = -0.62, P < 0.05), and wasted left ventricular energy (r = -0.61, P < 0.05) in young women. Conversely, baseline sympathetic activity was positively related to augmentation index (r = 0.63, P = 0.09), augmented pressure (r = 0.69, P < 0.05), and wasted left ventricular energy (r = 0.79, P < 0.05) in postmenopausal women. Conclusions: High levels of sympathetic activity are associated with higher indices of aortic wave reflection in postmenopausal women. Consequently, postmenopausal women with high sympathetic activity may be more at risk for developing cardiovascular diseases or experiencing adverse cardiovascular system-related events. C1 [Hart, Emma C.; Joyner, Michael J.; Barnes, Jill N.; Curry, Timothy B.; Casey, Darren P.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP Casey, DP (reprint author), Univ Iowa, Dept Phys Therapy & Rehabil Sci, Carver Coll Med, Iowa City, IA 52242 USA. EM darren-casey@uiowa.edu OI Hart, Emma/0000-0002-4534-9586 FU National Institutes of Health [HL083947, AR55819, AG038067, AHA 070036Z]; National Center for Research Resources [1 UL1 RR024150]; Mayo Foundation FX This study was supported by National Institutes of Health grants HL083947 (M.J.J. and N.C.), AR55819 (D.P.C.), AG038067 (J.N.B.), and AHA 070036Z (E.C.H.), and by National Center for Research Resources grant 1 UL1 RR024150. Additional support was received from the Mayo Foundation, including a philanthropic gift from the Caywood family and the Mayo Clinic Department of Anesthesia. NR 45 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1072-3714 EI 1530-0374 J9 MENOPAUSE JI Menopause-J. N. Am. Menopause Soc. PD SEP PY 2013 VL 20 IS 9 BP 960 EP 966 DI 10.1097/gme.0b013e3182843b59 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 300KS UT WOS:000330463400012 ER PT J AU Ruhl, DS Hong, SS Littlefield, PD AF Ruhl, Douglas S. Hong, Steven S. Littlefield, Philip D. TI Lessons Learned in Otologic Surgery: 30 Years of Malpractice Cases in the United States SO OTOLOGY & NEUROTOLOGY LA English DT Editorial Material DE Hearing loss; Lawsuit; Malpractice; Negligence; Otologic surgery ID MEDICAL-MALPRACTICE; MIDDLE-EAR; LITIGATION; OUTCOMES; CLAIMS AB Objective: To analyze malpractice litigation trends to better understand the causes and outcomes of suits involving otologic surgeries to prevent future litigation and improve physician awareness. Methods: Court records of legal trials from 1983 to 2012 were obtained from 2 major computerized databases-WESTLAW and LexisNexis. Data were compiled on the demographics of the defendant, plaintiff, use of otolaryngologists/otologists as expert witnesses, nature of injury, type of surgery, legal allegations, verdicts, and judgments. Results: Fifty-eight unique cases met inclusion criteria and were selected for review. The most common surgeries that went to trial were mastoidectomy (48%), ossiculoplasty (21%), and tympanoplasty (16%). Eleven (19%) of the cases were resolved through a settlement before a verdict was reached. Verdicts in favor of the plaintiffs (31%) were awarded an average of $1,131,189. The most common alleged injuries were hearing loss (45%) and facial nerve injury (38%). Of the cases found in favor of the plaintiff, the most common reasons cited were improper performance of the surgery (50%), failure to properly diagnose and treat (33%), and inadequate informed consent and delay in diagnosis (22% each). Case outcomes involving pediatric patients were not significantly different than those of adults (p = 0.34); however, adults received higher financial awards on average ($1 million versus $232,000; p < 0.0003). Conclusion: Obtaining an appropriate diagnosis, thoroughly discussing all options and potential risks, presenting realistic expectations, and executing the surgery correctly are crucial to patient care. Understanding the reasons surgeons go to trial may assist in mitigating risk for potential lawsuits. C1 [Ruhl, Douglas S.; Hong, Steven S.; Littlefield, Philip D.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM douglas.ruhl@amedd.army.mil OI Ruhl, Douglas/0000-0002-7411-2385 NR 22 TC 10 Z9 10 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 EI 1537-4505 J9 OTOL NEUROTOL JI Otol. Neurotol. PD SEP PY 2013 VL 34 IS 7 BP 1173 EP 1179 PG 7 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 301HI UT WOS:000330523000015 PM 23921931 ER PT J AU Hennion, DR Siano, KA AF Hennion, Duane R. Siano, Kelly A. TI Diagnosis and Treatment of Peripheral Arterial Disease SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ANKLE-BRACHIAL INDEX; INTERMITTENT CLAUDICATION; VASCULAR-DISEASE; RECOMMENDATION STATEMENT; CARDIOVASCULAR EVENTS; LOWER-EXTREMITY; TASK-FORCE; MANAGEMENT; RISK; METAANALYSIS AB Peripheral arterial disease (PAD) is atherosclerosis leading to narrowing of the major arteries distal to the aortic arch. The most common presenting symptom is claudication; however, only 10% of patients have classic claudication. Approximately 8 to 12 million Americans have PAD, including 15% to 20% of adults older than 70 years. The ankle-brachial index (ABI) can be used to screen for and diagnose PAD in the primary care setting. An ABI of less than 0.9 is associated with a two- to fourfold increase in relative risk for cardiovascular events and all-cause mortality. To improve cardiovascular risk stratification and risk factor modification, the American Diabetes Association recommends ABI screening for patients older than 50 years who have diabetes mellitus, and the American Heart Association recommends screening all patients 65 years and older and those 50 years and older who have a history of diabetes or smoking. Because there is no evidence that screening leads to fewer cardiovascular events or lower all-cause mortality, the U.S. Preventive Services Task Force recommends against screening for PAD. Management of claudication includes exercise, smoking cessation, statin therapy, and antiplatelet therapy with aspirin or dopidogrel, and possibly cilostazol in patients with no history of heart failure. Surgical revascularization may be considered in patients with lifestyle-limiting claudication symptoms that do not respond to medical therapy. Copyright (C) 2013 American Academy of Family Physicians. C1 [Hennion, Duane R.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hennion, Duane R.; Siano, Kelly A.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Hennion, DR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM duane.r.hennion@us.army.mil NR 27 TC 3 Z9 4 U1 0 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 2013 VL 88 IS 5 BP 306 EP 310 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 297QZ UT WOS:000330271300006 PM 24010393 ER PT J AU Dong, H Snyder, JF Williams, KS Andzelm, JW AF Dong, Hong Snyder, James F. Williams, Kristen S. Andzelm, Jan W. TI Cation-Induced Hydrogels of Cellulose Nanofibrils with Tunable Moduli SO BIOMACROMOLECULES LA English DT Article ID TEMPO-MEDIATED OXIDATION; NATIVE CELLULOSE; TRANSPARENT; MOLECULES; NANOPARTICLES; COMPOSITES; SYSTEM; FILM AB Cellulose nanofibrils are biocompatible nanomaterials derived from sustainable natural sources. We report hydrogelation of carboxylated cellulose nanofibrils with divalent or trivalent cations (Ca2+, Zn2+, Cu2+, Al3+, and Fe3+) and subsequent formation of interconnected porous nanofibril networks. The gels were investigated by dynamic viscoelastic measurements. The storage moduli of the gels are strongly related to valency of the metal cations and their binding strength with carboxylate groups on the nanofibrils. Hydrogel moduli may be tuned by appropriate choice of cation. Cation-carboxylate interactions are proposed to initiate gelation by screening of the repulsive charges on the nanofibrils and to dominate gel properties through ionic cross-linking. Binding energies of cations with carboxylate groups were calculated from molecular models developed for nanofibril surfaces to validate the correlation and provide further insight into the cross-linked structures. The cellulose nanofibril-based hydrogels may have a variety of biomedical and other applications, taking advantage of their biocompatibility, high porosity, high surface area, and durability in water and organic solvents. C1 [Dong, Hong; Snyder, James F.; Williams, Kristen S.; Andzelm, Jan W.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Dong, Hong] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. RP Dong, H (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM hong.dong.ctr@mail.mil FU Oak Ridge Institute for Science and Education FX The authors would like to thank Dr. Alan Rudie and Mr. Richard Reiner at USDA Forest Product Laboratory (FPL) for courtesy of providing CNF dispersions. Dr. Joshua Orlicki and Dr. Randy Mrozek at Army Research Laboratory (ARL) and Dr. Alan Rudie at FPL are acknowledged for useful discussions. Mr. Joshua Steele at ARL is acknowledged for help in the supercritical CO2 drying process. K.W. acknowledges support as a Postdoctoral Fellow from the Oak Ridge Institute for Science and Education. NR 32 TC 36 Z9 37 U1 6 U2 72 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 EI 1526-4602 J9 BIOMACROMOLECULES JI Biomacromolecules PD SEP PY 2013 VL 14 IS 9 BP 3338 EP 3345 DI 10.1021/bm400993f PG 8 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 295CZ UT WOS:000330095500043 PM 23919541 ER PT J AU Vecherin, SN Ostashev, VE Wilson, DK AF Vecherin, Sergey N. Ostashev, Vladimir E. Wilson, D. Keith TI Assessment of systematic measurement errors for acoustic travel-time tomography of the atmosphere SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID DEPENDENT STOCHASTIC INVERSION; VECTOR-FIELDS; SURFACE-LAYER; RECONSTRUCTION; TEMPERATURE; ANIMALS; MODEL; WIND AB Two algorithms are described for assessing systematic errors in acoustic travel-time tomography of the atmosphere, the goal of which is to reconstruct the temperature and wind velocity fields given the transducers' locations and the measured travel times of sound propagating between each speaker-microphone pair. The first algorithm aims at assessing the errors simultaneously with the mean field reconstruction. The second algorithm uses the results of the first algorithm to identify the ray paths corrupted by the systematic errors and then estimates these errors more accurately. Numerical simulations show that the first algorithm can improve the reconstruction when relatively small systematic errors are present in all paths. The second algorithm significantly improves the reconstruction when systematic errors are present in a few, but not all, ray paths. The developed algorithms were applied to experimental data obtained at the Boulder Atmospheric Observatory. (C) 2013 Acoustical Society of America. C1 [Vecherin, Sergey N.; Wilson, D. Keith] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80305 USA. RP Vecherin, SN (reprint author), US Army Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM sergey.n.vecherin@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF1010415] FX This material is based upon work supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under contract/grant number W911NF1010415. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 32 TC 1 Z9 1 U1 0 U2 6 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2013 VL 134 IS 3 BP 1802 EP 1813 DI 10.1121/1.4816411 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 294LG UT WOS:000330047000011 PM 23967914 ER PT J AU Pasiakos, SM Cao, JJ Margolis, LM Sauter, ER Whigham, LD McClung, JP Rood, JC Carbone, JW Combs, GF Young, AJ AF Pasiakos, Stefan M. Cao, Jay J. Margolis, Lee M. Sauter, Edward R. Whigham, Leah D. McClung, James P. Rood, Jennifer C. Carbone, John W. Combs, Gerald F., Jr. Young, Andrew J. TI Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial SO FASEB JOURNAL LA English DT Article DE recommended dietary allowance; fractional synthesis rate; nitrogen balance; skeletal muscle; postprandial; energy deficit ID ENERGY-EXPENDITURE; BODY-COMPOSITION; ENDURANCE EXERCISE; YOUNG MEN; RESISTANCE EXERCISE; NITROGEN-BALANCE; SKELETAL-MUSCLE; DOSE-RESPONSE; OLDER-ADULTS; POUNDS LOST AB The purpose of this work was to determine the effects of varying levels of dietary protein on body composition and muscle protein synthesis during energy deficit (ED). A randomized controlled trial of 39 adults assigned the subjects diets providing protein at 0.8 (recommended dietary allowance; RDA), 1.6 (2x-RDA), and 2.4 (3x-RDA) g kg(-1) d(-1) for 31 d. A 10-d weight-maintenance (WM) period was followed by a 21 d, 40% ED. Body composition and postabsorptive and postprandial muscle protein synthesis were assessed during WM (d 9-10) and ED (d 30-31). Volunteers lost (P<0.05) 3.2 +/- 0.2 kg body weight during ED regardless of dietary protein. The proportion of weight loss due to reductions in fat-free mass was lower (P<0.05) and the loss of fat mass was higher (P<0.05) in those receiving 2x-RDA and 3x-RDA compared to RDA. The anabolic muscle response to a protein-rich meal during ED was not different (P>0.05) from WM for 2x-RDA and 3x-RDA, but was lower during ED than WM for those consuming RDA levels of protein (energy x protein interaction, P<0.05). To assess muscle protein metabolic responses to varied protein intakes during ED, RDA served as the study control. In summary, we determined that consuming dietary protein at levels exceeding the RDA may protect fat-free mass during short-term weight loss.Pasiakos, S. M., Cao, J. J., Margolis, L. M., Sauter, E. R., Whigham, L. D., McClung, J. P., Rood, J. C., Carbone, J. W., Combs, G. F., Jr., Young, A. J. Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial. C1 [Pasiakos, Stefan M.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Cao, Jay J.; Whigham, Leah D.; Combs, Gerald F., Jr.] ARS, Grand Forks Human Nutr Res Ctr, USDA, Grand Forks, ND USA. [Sauter, Edward R.] Univ N Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304; Whigham, Leah/0000-0002-5376-8967 FU U.S. Army Medical Research and Material Command; U.S. Department of Defense; U.S. Department of Agriculture, Agricultural Research Service [58-1950-7-707] FX First, the authors thank the volunteers that participated in this research experiment. The authors acknowledge Doreen Rolshoven, LuAnn Johnson, Bonita Hoverson, Angela Scheett, Debbie Krause, and the dietary kitchen staff, Emily Nielson, Jackie Nelson, Jean Hager, and Dr. William Siders (U. S. Department of Agriculture Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA) for their significant contributions to study management and conduct, data collection, and analysis. The authors acknowledge William Mills, Matthew Dickson, Bryan Wiley, Michael Stanger, Lauren Thompson, Philip Niro, and Dr. Hedrick Porrata (U. S. Army Research Institute of Environmental Medicine, Nantick, MA, USA) for their significant contributions to data collection and assistance with manuscript layout and design. Finally, the authors sincerely thank Nancy Murphy (U. S. Army Research Institute of Environmental Medicine) for her significant contributions to data collection, management, and analysis. The study was supported by the U. S. Army Medical Research and Material Command and the U. S. Department of Agriculture, Agricultural Research Service. Author contributions: S. M. P. performed project conception, development of overall research plan, study oversight, research, data analysis, and manuscript preparation, and had primary responsibility for final content; L. M. M., J.J.C., L. D. W., J.P.M., J.W.C., G. F. C., and A.J.Y. assisted with project conception, development of research plan, study implementation and management, data analysis, and manuscript preparation; E. R. S. performed muscle biopsies, provided medical oversight, and assisted in manuscript preparation; J.C.R. performed stable isotope and urinary nitrogen analysis. S. M. P. reports that his institution received a grant from the Dairy Research Institute for work outside this publication. E. R. S. reports that his institution received a grant and travel support from the U. S. Department of Agriculture for work associated with this publication. E. R. S. also reports that he is a consultant for Halo Health, has received royalties for book editorship, and has received a patent. J.P.M. reports that his institution received a grant from the U.S. Army Medical Research and Material Command for work outside this publication. J.C.R. reports that her institution received a grant from the U.S. Department of Defense for work associated with this publication. The other authors report no conflicts of interest. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. This material is based on work supported by the U.S. Department of Agriculture, Agricultural Research Service, under agreement No. 58-1950-7-707. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the U. S. Department of Agriculture. This trial was registered at http://www.clinicaltrials.gov as NCT01292395. NR 52 TC 44 Z9 44 U1 1 U2 28 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD SEP PY 2013 VL 27 IS 9 BP 3837 EP 3847 DI 10.1096/fj.13-230227 PG 11 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 277SV UT WOS:000328840500041 PM 23739654 ER PT J AU Krakauer, T AF Krakauer, Teresa TI Update on Staphylococcal Superantigen-Induced Signaling Pathways and Therapeutic Interventions SO TOXINS LA English DT Review DE staphylococcal superantigens; SEB; cytokine signaling; PI3K; mTOR; NFB; FDA-approved drugs ID TOXIC-SHOCK-SYNDROME; COMPLEX CLASS-II; T-CELL-ACTIVATION; NF-KAPPA-B; BLOOD MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; EXOTOXIN-INDUCED CYTOKINES; INFLAMMATORY LUNG INJURY; NUCLEAR IMPORT INHIBITOR; RECEPTOR BETA-CHAIN AB Staphylococcal enterotoxin B (SEB) and related bacterial toxins cause diseases in humans and laboratory animals ranging from food poisoning, acute lung injury to toxic shock. These superantigens bind directly to the major histocompatibility complex class II molecules on antigen-presenting cells and specific V regions of T-cell receptors (TCR), resulting in rapid hyper-activation of the host immune system. In addition to TCR and co-stimulatory signals, proinflammatory mediators activate signaling pathways culminating in cell-stress response, activation of NFB and mammalian target of rapamycin (mTOR). This article presents a concise review of superantigen-activated signaling pathways and focuses on the therapeutic challenges against bacterial superantigens. C1 US Army, Dept Immunol, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Dept Immunol, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM teresa.krakauer@us.army.mil FU Defense Threat Reduction Agency FX I thank the Defense Threat Reduction Agency for generous support. NR 166 TC 21 Z9 21 U1 0 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD SEP PY 2013 VL 5 IS 9 BP 1629 EP 1654 DI 10.3390/toxins5091629 PG 26 WC Toxicology SC Toxicology GA 274TI UT WOS:000328628700008 PM 24064719 ER PT J AU Leiter, KW Crone, JC Knap, J AF Leiter, Kenneth W. Crone, Joshua C. Knap, Jaroslaw TI An algorithm for massively parallel dislocation dynamics simulations of small scale plasticity SO JOURNAL OF COMPUTATIONAL SCIENCE LA English DT Article DE Dislocation dynamics; Finite element method; Parallel computing ID MESOSCOPIC SCALE; THIN-FILMS; MECHANICAL-PROPERTIES; TRENDS; MODEL; SIZE AB Accurate modeling of dislocation motion in bounded bodies is essential for the goal of obtaining desired properties, for example electronic or optical, of many microelectronic devices. At present, we lack high fidelity computer codes for such modeling that efficiently utilize modern parallel computer architectures. In contrast, many dislocation simulation codes are available for periodic or infinite bodies. In principle, these codes can be extended to allow for dislocation modeling in finite bodies. However, such extension may involve an additional solver to be employed, coupled with a dislocation simulation code. We present an algorithm for development of parallel dislocation simulation capability for bounded bodies based on such coupling. Subsequently, we analyze the performance of the algorithm for a demanding dislocation dynamics model problem. Published by Elsevier B.V. C1 [Leiter, Kenneth W.; Crone, Joshua C.; Knap, Jaroslaw] US Army Res Lab, RDRL CIH C, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. RP Knap, J (reprint author), US Army Res Lab, RDRL CIH C, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. EM jaroslaw.knap@us.army.mil NR 59 TC 5 Z9 5 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1877-7503 J9 J COMPUT SCI-NETH JI J. Comput. Sci. PD SEP PY 2013 VL 4 IS 5 SI SI BP 401 EP 411 DI 10.1016/j.jocs.2013.02.002 PG 11 WC Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods SC Computer Science GA 270CS UT WOS:000328297100012 ER PT J AU Chin, ML Periasamy, P O'Regan, TP Amani, M Tan, C O'Hayre, RP Berry, JJ Osgood, RM Parilla, PA Ginley, DS Dubey, M AF Chin, Matthew L. Periasamy, Prakash O'Regan, Terrance P. Amani, Matin Tan, Cheng O'Hayre, Ryan P. Berry, Joseph J. Osgood, Richard M., III Parilla, Philip A. Ginley, David S. Dubey, Madan TI Planar metal-insulator-metal diodes based on the Nb/Nb2O5/X material system SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID ELECTRODES; FILM; RADIATION; ELEMENTS AB The authors report the performance of various planar metal-insulator-metal (MIM) tunneling diodes, which are being investigated for use in rectenna devices for energy harvesting applications. Six cathode materials (M-2): Nb, Ag, Cu, Ni, Au, and Pt are studied in conjunction with Nb as the anode (M-1) and Nb2O5 (I) as the dielectric. The cathode materials selections were based on results from a prior rapid-screening study that employed a bent-wire metal cathode point-contact method. Planar devices, to enable analysis using standard MIM diode models, were fabricated with the resultant current density-voltage data obtained at both room temperature and 77K. The tunnel barrier heights and dielectric properties for these systems were extracted from the modeling results. Nb/Nb2O5/Pt MIM diodes showed the best performance with an asymmetry ratio greater than 7700, a nonlinearity value of 4.7, and a responsivity of 16.9, all at 0.5V and 300 K. These results confirm prior rapid-screening efforts and further validate the Nb/Nb2O5/Pt system in particular as a promising MIM architecture due to the low barrier height of the junction. (C) 2013 American Vacuum Society. C1 [Chin, Matthew L.; O'Regan, Terrance P.; Amani, Matin; Tan, Cheng; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Periasamy, Prakash; O'Hayre, Ryan P.] Colorado Sch Mines, Dept Met & Mat Engn, Golden, CO 80401 USA. [Berry, Joseph J.; Parilla, Philip A.; Ginley, David S.] Natl Renewable Energy Lab, Golden, CO 80401 USA. [Osgood, Richard M., III] US Army Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Chin, ML (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM matthew.l.chin2.civ@mail.mil FU U.S. Department of Energy [DE-AC36-08-GO28308]; National Renewable Energy Laboratory, as part of the Laboratory Directed Research and Development Program; Centre for Revolutionary Solar Photoconversion (CRSP); Army Research Office [W911NF-12-1-0474] FX This work was supported by the U.S. Department of Energy under Contract No. DE-AC36-08-GO28308 with the National Renewable Energy Laboratory, as part of the Laboratory Directed Research and Development Program and was also supported by funding from the Centre for Revolutionary Solar Photoconversion (CRSP). Part of this work is supported by funding from Army Research Office under Contract No. W911NF-12-1-0474. The authors thank Harvey Guthrey and Brian Gorman at CSM for their help in obtaining TEM images. NR 26 TC 3 Z9 3 U1 3 U2 13 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP PY 2013 VL 31 IS 5 AR 051204 DI 10.1116/1.4818313 PG 8 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 261ZE UT WOS:000327702800012 ER PT J AU Sarney, WL Svensson, SP AF Sarney, Wendy L. Svensson, Stefan P. TI Discrepancies in the nature of nitrogen incorporation in dilute-nitride GaSbN and GaAsN films SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MOLECULAR-BEAM EPITAXY; LUMINESCENCE EFFICIENCY; ALLOYS; GROWTH; GANXAS1-X AB The authors studied the incorporation of dilute concentrations of nitrogen into GaSb and GaAs. There is a dissimilar interaction of N-Sb compared to N-As for films grown in the same manner, as indicated by discrepancies in x-ray diffraction and chemical analysis, and consistent with measured changes in the bandgap. The N in GaSb1-xNx resides in a quantifiable, "dark" phase correlating with the larger negative impact on the GaSb1-xNx optical properties relative to GaAS(1-x)N(x). The authors hypothesize that the missing N resides in a phase that is optically inactive or have a much wider bandgap than the matrix material. C1 [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wendy.l.sarney.civ@mail.mil NR 23 TC 2 Z9 2 U1 0 U2 9 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP PY 2013 VL 31 IS 5 AR 051206 DI 10.1116/1.4819303 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 261ZE UT WOS:000327702800014 ER PT J AU Stuart, SC Satchet, E Sandin, A Maria, JP Rowe, JE Dougherty, DB Ulrich, M AF Stuart, Sean C. Satchet, Edward Sandin, Andreas Maria, Jon-Paul Rowe, John E. (Jack) Dougherty, Daniel B. Ulrich, Marc TI Smooth MgO films grown on graphite and graphene by pulsed laser deposition SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID EPITAXIAL GRAPHENE; SPIN TRANSPORT; SURFACES; XPS AB Pulsed laser deposition was used to grow thin (1-100 nm) magnesium oxide films directly on graphite and epitaxial graphene on SiC(0001). The authors observe very smooth (typical rms roughness of similar to 0.4 nm) film morphologies that are nearly independent of film thickness and conformal to the substrate for films grown on room temperature substrates. Surface roughness is less than 1 nm for thicknesses up to 100 nm and is independent of oxygen background pressure during growth. X-ray diffraction shows no evidence of crystallinity for films grown on room temperature substrates but shows < 100 > texture for films grown on heated substrates that also have very rough surface morphologies. X-ray photoelectron spectroscopy shows hydroxylation of films due to air exposure that can only be partially removed by annealing, indicating the presence of atomic defects in the films. (C) 2013 American Vacuum Society. C1 [Stuart, Sean C.; Sandin, Andreas; Rowe, John E. (Jack); Dougherty, Daniel B.; Ulrich, Marc] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Satchet, Edward; Maria, Jon-Paul] N Carolina State Univ, Dept Mat Sci, Raleigh, NC 27695 USA. [Ulrich, Marc] Army Res Off, Div Phys, Res Triangle Pk, NC 27709 USA. RP Ulrich, M (reprint author), N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. EM marc.d.ulrich.civ@mail.mil FU Army Research Office [W911NF-04-D-0003] FX This work was funded by the Army Research Office under Agreement No. W911NF-04-D-0003. NR 31 TC 2 Z9 2 U1 4 U2 31 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP PY 2013 VL 31 IS 5 AR 051804 DI 10.1116/1.4818511 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 261ZE UT WOS:000327702800025 ER PT J AU Gray, GE Michael, NL AF Gray, Glenda E. Michael, Nelson L. TI Cautious optimism for HIV vaccine science SO CURRENT OPINION IN HIV AND AIDS LA English DT Editorial Material ID DOUBLE-BLIND; EFFICACY; TRIAL C1 [Gray, Glenda E.] Univ Witwatersrand, Perinatal HIV Res Unit, Soweto, South Africa. [Michael, Nelson L.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Michael, NL (reprint author), Walter Reed Army Inst Res, Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nelson.l.michael2.mil@mail.mil FU NIAID NIH HHS [UM1 AI108568] NR 14 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD SEP PY 2013 VL 8 IS 5 BP 367 EP 368 DI 10.1097/01.COH.0000432529.38768.1f PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 248US UT WOS:000326730500001 PM 23924996 ER PT J AU Edlefsen, PT Gilbert, PB Rolland, M AF Edlefsen, Paul T. Gilbert, Peter B. Rolland, Morgane TI Sieve analysis in HIV-1 vaccine efficacy trials SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE HIV-1 breakthrough infections; sieve analysis; vaccine-induced immune responses; viral genetics ID IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTION; STEP; ANTIBODIES; IMMUNITY; REGIONS; RV144; GP120 AB Purpose of reviewThe genetic characterization of HIV-1 breakthrough infections in vaccine and placebo recipients offers new ways to assess vaccine efficacy trials. Statistical and sequence analysis methods provide opportunities to mine the mechanisms behind the effect of an HIV vaccine.Recent findingsThe release of results from two HIV-1 vaccine efficacy trials, Step/HVTN-502 (HIV Vaccine Trials Network-502) and RV144, led to numerous studies in the last 5 years, including efforts to sequence HIV-1 breakthrough infections and compare viral characteristics between the vaccine and placebo groups. Novel genetic and statistical analysis methods uncovered features that distinguished founder viruses isolated from vaccinees from those isolated from placebo recipients, and identified HIV-1 genetic targets of vaccine-induced immune responses.SummaryStudies of HIV-1 breakthrough infections in vaccine efficacy trials can provide an independent confirmation to correlates of risk studies, as they take advantage of vaccine/placebo comparisons, whereas correlates of risk analyses are limited to vaccine recipients. Through the identification of viral determinants impacted by vaccine-mediated host immune responses, sieve analyses can shed light on potential mechanisms of vaccine protection. C1 [Edlefsen, Paul T.; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Rolland, Morgane] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Rolland, M (reprint author), US Mil HIV Res Program MHRP, HJF, Viral Genet Sect, 503 Robert Grant Ave,Room 2A46, Silver Spring, MD 20910 USA. EM mrolland@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0 174]; US Department of Defense (DoD) [W81XWH-11-2-0 174]; US Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases [Y1-AI-2642-12]; National Institute Of Allergy And Infectious Diseases of the National Institutes of Health [R37AI054165] FX This work was supported by a cooperative agreement (W81XWH-11-2-0 174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DoD), by an Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research and Material Command (USAMRMC) and the National Institute of Allergy and Infectious Diseases, and by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R37AI054165 (to P.B.G). NR 21 TC 11 Z9 11 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD SEP PY 2013 VL 8 IS 5 BP 432 EP 436 DI 10.1097/COH.0b013e328362db2b PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 248US UT WOS:000326730500009 PM 23719202 ER PT J AU Vandewege, MW Swannack, TM Greuter, KL Brown, DJ Forstner, MRJ AF Vandewege, Michael W. Swannack, Todd M. Greuter, Kensley L. Brown, Donald J. Forstner, Michael R. J. TI BREEDING SITE FIDELITY AND TERRESTRIAL MOVEMENT OF AN ENDANGERED AMPHIBIAN, THE HOUSTON TOAD (BUFO HOUSTONENSIS) SO HERPETOLOGICAL CONSERVATION AND BIOLOGY LA English DT Article DE Bufo houstonensis; connectivity; dispersal; Houston Toad; juvenile; adult; site fidelity; Texas ID HABITAT LOSS; JUVENILE DISPERSAL; CONSERVATION; METAPOPULATION; LANDSCAPE; ECOLOGY; FOREST; FRAGMENTATION; CONNECTIVITY; SELECTION AB The Houston Toad (Bufo [Anaxyrus] houstonensis) is a federally endangered species endemic to east-central texas, USA. understanding movement patterns of this species during different life stages is critical for development and implementation of landscape-scale recovery initiatives. We used breeding survey, terrestrial movement, telemetry, and juvenile dispersal data to characterize B. houstonensis movement patterns. B. houstonensis were found to exhibit a high level of breeding site fidelity within and among years, with the majority of recaptured adult toads remaining within 75 m of the pond of initial capture. however, long-distance dispersal (up to 777 m) was observed for adults, which suggests that connectivity among local subpopulations could be maintained through occasional dispersal of individuals. additionally, our movement data and the rarity of captures outside of woodlands support the assumption that B. houstonensis prefer forested habitat. to maximize the potential for long-term persistence of toad populations, we recommend that land managers focus on maintaining and restoring a matrix of ponds in forested communities that support and provide connectivity among critical habitats. C1 [Vandewege, Michael W.] Mississippi State Univ, Dept Biochem Mol Biol Entomol & Plant Pathol, Mississippi State, MS 39762 USA. [Swannack, Todd M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Greuter, Kensley L.] SWCA Environm Consultants, Austin, TX 78749 USA. [Brown, Donald J.; Forstner, Michael R. J.] Texas State Univ San Marcos, Dept Biol, San Marcos, TX 78666 USA. RP Vandewege, MW (reprint author), Mississippi State Univ, Dept Biochem Mol Biol Entomol & Plant Pathol, Mississippi State, MS 39762 USA. EM mike.vandewege@gmail.com FU Texas Parks and Wildlife Department [SPR-0102-191, SPR-0290-022]; U.S. Fish and Wildlife Service [TE 039544-0, TE 039544-1, TE 039544-2, TE 004472-0, TE 004472-1] FX We thank all of the individuals who assisted with Houston Toad call survey and trapping work, particularly Jake Jackson and Jim Bell. The BSA provided access to the GLR and we are grateful for their support of Houston Toad recovery and conservation initiatives. Primary funding and research permits were provided by the Texas Parks and Wildlife Department (permits SPR-0102-191 and SPR-0290-022), and the U.S. Fish and Wildlife Service (permits TE 039544-0, TE 039544-1, TE 039544-2, TE 004472-0, and TE 004472-1). This research was approved by the Texas State University-San Marcos Institutional Animal Care and Use Committee (approval codes 5Qrs45_02, HGVMAD_02, 04-0485904A30, 0713_0428_07, and 0810_0208_11). NR 53 TC 1 Z9 1 U1 4 U2 27 PU HERPETOLOGICAL CONSERVATION & BIOLOGY PI CORVALLIS PA C/O R BRUCE BURY, USGS FOREST & RANGELAND, CORVALLIS, OR 00000 USA SN 2151-0733 EI 1931-7603 J9 HERPETOL CONSERV BIO JI Herpetol. Conserv. Biol. PD SEP PY 2013 VL 8 IS 2 BP 435 EP 446 PG 12 WC Zoology SC Zoology GA 257AH UT WOS:000327354800016 ER PT J AU Weaver, LK Dicks, C Deru, K Miller, RS AF Weaver, Lindell K. Dicks, Cheryl Deru, Kayla Miller, R. Scott TI Regulatory considerations for a traumatic brain injury (TBI) indication for hyperbaric oxygen (HBO2) SO UNDERSEA AND HYPERBARIC MEDICINE LA English DT Article C1 [Weaver, Lindell K.; Deru, Kayla] Intermt LDS Hosp, Hyperbar Med Div, Salt Lake City, UT USA. [Weaver, Lindell K.; Deru, Kayla] Intermt Med Ctr, Murray, UT USA. [Weaver, Lindell K.] Univ Utah, Sch Med, Salt Lake City, UT USA. [Dicks, Cheryl] Clin Res Management Inc, Ft Detrick, MD USA. [Miller, R. Scott] US Army Med Mat Dev Act, Ft Detrick, MD USA. RP Weaver, LK (reprint author), Intermt LDS Hosp, Hyperbar Med Div, Salt Lake City, UT USA. EM lindell.weaver@imail.org NR 6 TC 2 Z9 2 U1 0 U2 3 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI DURHAM PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA SN 1066-2936 J9 UNDERSEA HYPERBAR M JI Undersea Hyperb. Med. PD SEP-OCT PY 2013 VL 40 IS 5 BP 439 EP 441 PG 3 WC Marine & Freshwater Biology; Medicine, Research & Experimental SC Marine & Freshwater Biology; Research & Experimental Medicine GA 252YW UT WOS:000327049800010 PM 24224287 ER PT J AU McCrary, BF Weaver, L Marrs, K Miller, RS Dicks, C Deru, K Close, N DeJong, M AF McCrary, Brian F. Weaver, Lindell Marrs, Kevin Miller, R. Scott Dicks, Cheryl Deru, Kayla Close, Nicole DeJong, Marla TI Hyperbaric oxygen (HBO2) for post-concussive syndrome/chronic TBI Product summary SO UNDERSEA AND HYPERBARIC MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; POSTCONCUSSION SYNDROME; SKELETAL-MUSCLE; CLINICAL-TRIAL; WOUND MODEL; IN-VIVO; THERAPY; TOXICITY; GROWTH; ANGIOGENESIS C1 [McCrary, Brian F.; Marrs, Kevin; Miller, R. Scott] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Weaver, Lindell; Deru, Kayla] Intermt LDS Hosp, Salt Lake City, UT USA. [Weaver, Lindell] Intermt Med Ctr, Murray, UT USA. [Dicks, Cheryl] Clin Res Management Inc, Ft Detrick, MD USA. [Close, Nicole] EmpiriStat Inc, Mt Airy, MD USA. [DeJong, Marla] US Air Force Sch Aerosp Med, Wright Patterson AFB, OH USA. RP McCrary, BF (reprint author), US Army Med Mat Dev Act, Ft Detrick, MD USA. EM mccrarymia@gmail.com NR 134 TC 2 Z9 2 U1 3 U2 13 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI DURHAM PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA SN 1066-2936 J9 UNDERSEA HYPERBAR M JI Undersea Hyperb. Med. PD SEP-OCT PY 2013 VL 40 IS 5 BP 443 EP 467 PG 25 WC Marine & Freshwater Biology; Medicine, Research & Experimental SC Marine & Freshwater Biology; Research & Experimental Medicine GA 252YW UT WOS:000327049800011 PM 24224288 ER PT J AU Weaver, LK Cifu, D Hart, B Wolf, G Miller, RS AF Weaver, Lindell K. Cifu, David Hart, Brett Wolf, George Miller, R. Scott TI Reply: Department of Defense trials for hyperbaric oxygen and TBI: Issues of study design and questionable conclusions SO UNDERSEA AND HYPERBARIC MEDICINE LA English DT Letter ID POST-CONCUSSION SYNDROME; CLINICAL-TRIALS; PRESSURES C1 [Weaver, Lindell K.] Intermt LDS Hosp, Salt Lake City, UT USA. [Weaver, Lindell K.] Intermt Med Ctr, Murray, UT USA. [Weaver, Lindell K.] Univ Utah, Sch Med, Salt Lake City, UT USA. [Cifu, David] PM&R Program Off, Dept Vet Affairs, Washington, DC USA. [Cifu, David] Virginia Commonwealth Univ, Dept PM&R, Richmond, VA USA. [Hart, Brett] Detachment Naval Aerosp Med Inst NAMI, Navy Med Operat Training Ctr, Hyperbar Med Dept, Pensacola, FL USA. [Wolf, George] USAF Sch Aerosp Med, Hyperbar Med Dept, Lackland AFB, TX USA. [Miller, R. Scott] USAM MDA, US Army Med Mat Dev Activ, Ft Detrick, MD USA. RP Weaver, LK (reprint author), Intermt LDS Hosp, Salt Lake City, UT USA. EM lindell.weaver@imail.org NR 7 TC 0 Z9 0 U1 0 U2 2 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI DURHAM PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA SN 1066-2936 J9 UNDERSEA HYPERBAR M JI Undersea Hyperb. Med. PD SEP-OCT PY 2013 VL 40 IS 5 BP 471 EP 472 PG 2 WC Marine & Freshwater Biology; Medicine, Research & Experimental SC Marine & Freshwater Biology; Research & Experimental Medicine GA 252YW UT WOS:000327049800013 PM 24224290 ER PT J AU Mitrophanov, AY Rosendaal, FR Reifman, J AF Mitrophanov, Alexander Y. Rosendaal, Frits R. Reifman, Jaques TI Computational Analysis of the Effects of Reduced Temperature on Thrombin Generation: The Contributions of Hypothermia to Coagulopathy SO ANESTHESIA AND ANALGESIA LA English DT Article ID PLASMA FACTOR COMPOSITION; RECOMBINANT FACTOR VIIA; IN-VITRO; BLOOD-COAGULATION; PROTHROMBIN TIME; LIVER-INJURIES; WHOLE-BLOOD; ACIDOSIS; DEPENDENCE; TRAUMA AB BACKGROUND: Hypothermia, which can result from tissue hypoperfusion, body exposure, and transfusion of cold resuscitation fluids, is a major factor contributing to coagulopathy of trauma and surgery. Despite considerable efforts, the mechanisms of hypothermia-induced blood coagulation impairment have not been fully understood. We introduce a kinetic modeling approach to investigate the effects of hypothermia on thrombin generation. METHODS: We extended a validated computational model to predict and analyze the impact of low temperatures (with or without concomitant blood dilution) on thrombin generation and its quantitative parameters. The computational model reflects the existing knowledge about the mechanistic details of thrombin generation biochemistry. We performed the analysis for an average subject, as well as for 472 subjects in the control group of the Leiden Thrombophilia Study. RESULTS: We computed and analyzed thousands of kinetic curves characterizing the generation of thrombin and the formation of the thrombin-antithrombin complex (TAT). In all simulations, hypothermia in the temperature interval 31 degrees C to 36 degrees C progressively slowed down thrombin generation, as reflected by clotting time, thrombin peak time, and prothrombin time, which increased in all subjects (P < 10(-5)). Maximum slope of the thrombin curve was progressively decreased, and the area under the thrombin curve was increased in hypothermia (P < 10(-5)); thrombin peak height remained practically unaffected. TAT formation was noticeably delayed (P < 10(-5)), but the final TAT levels were not significantly affected. Hypothermia-induced fold changes in the affected thrombin generation parameters were larger for lower temperatures, but were practically independent of the parameter itself and of the subjects' clotting factor composition, despite substantial variability in the subject group. Hypothermia and blood dilution acted additively on the thrombin generation parameters. CONCLUSIONS: We developed a general computational strategy that can be used to simulate the effects of changing temperature on the kinetics of biochemical systems and applied this strategy to analyze the effects of hypothermia on thrombin generation. We found that thrombin generation can be noticeably impaired in subjects with different blood plasma composition even in moderate hypothermia. Our work provides mechanistic support to the notion that thrombin generation impairment may be a key factor in coagulopathy induced by hypothermia and complicated by blood plasma dilution. C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Frederick, MD 21702 USA. [Rosendaal, Frits R.] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. [Rosendaal, Frits R.] Leiden Univ, Med Ctr, Dept Thrombosis & Haemostasis, Leiden, Netherlands. RP Mitrophanov, AY (reprint author), US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, 504 Scott St, Frederick, MD 21702 USA. EM alex@bhsai.org; jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Frederick, MD, as part of the U.S. Army's Network Science Initiative; Netherlands Heart Foundation [89-063] FX AYM and JR were supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Frederick, MD, as part of the U.S. Army's Network Science Initiative. The Leiden Thrombophilia Study, completed previously (FRR), was funded by the Netherlands Heart Foundation (89-063). NR 42 TC 11 Z9 11 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 EI 1526-7598 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 2013 VL 117 IS 3 BP 565 EP 574 DI 10.1213/ANE.0b013e31829c3b22 PG 10 WC Anesthesiology SC Anesthesiology GA 248JJ UT WOS:000326695200004 PM 23868891 ER PT J AU Reddoch, K Montgomery, R Nair, P Fedyk, C Pidcoke, HF Ramasubramanian, A Cap, AP AF Reddoch, K. Montgomery, R. Nair, P. Fedyk, C. Pidcoke, H. F. Ramasubramanian, A. Cap, A. P. TI Platelets Stored for 14 Days at 4 C are Comparable to Standard Room Temperature Storage for 5 Days SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting and CTTXPO CY OCT 12-15, 2013 CL Denver, CO SP AABB C1 [Reddoch, K.; Nair, P.; Ramasubramanian, A.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Reddoch, K.; Montgomery, R.; Fedyk, C.; Pidcoke, H. F.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. EM kreddoch@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2013 VL 53 SU 2 SI SI BP 70A EP 70A PG 1 WC Hematology SC Hematology GA 218CA UT WOS:000324409000139 ER PT J AU Cap, AP Reddoch, K Montgomery, R Pidcoke, HF Ramasubramanian, A Shumeev, A Ilyin, I Herschel, L Waters, SL Dumont, LJ AF Cap, A. P. Reddoch, K. Montgomery, R. Pidcoke, H. F. Ramasubramanian, A. Shumeev, A. Ilyin, I. Herschel, L. Waters, S. L. Dumont, L. J. TI Functionality of Chilled Platelets Stored under Hyperbaric Xenon SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting and CTTXPO CY OCT 12-15, 2013 CL Denver, CO SP AABB C1 [Cap, A. P.; Reddoch, K.; Montgomery, R.; Pidcoke, H. F.; Ramasubramanian, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Reddoch, K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Shumeev, A.; Ilyin, I.] Adv Preservat Technol, Boston, MA USA. [Herschel, L.; Waters, S. L.; Dumont, L. J.] Dartmouth Hitchcock Med Ctr, Hanover, NH USA. EM andrew.p.cap.mil@mail.mil RI Dumont, Larry/B-3994-2011 OI Dumont, Larry/0000-0002-1715-0748 NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2013 VL 53 SU 2 SI SI BP 80A EP 80A PG 1 WC Hematology SC Hematology GA 218CA UT WOS:000324409000161 ER PT J AU Parida, BK Garrastazu, H Cap, AP McFaul, SJ AF Parida, B. K. Garrastazu, H. Cap, A. P. McFaul, S. J. TI Silica Beads are Superior to Polystyrene for Sizing Cellular Microparticles SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting and CTTXPO CY OCT 12-15, 2013 CL Denver, CO SP AABB C1 [Parida, B. K.; Garrastazu, H.; Cap, A. P.; McFaul, S. J.] US Army Inst Surg Res, San Antonio, TX USA. EM bijaya.k.parida.vol@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2013 VL 53 SU 2 SI SI BP 130A EP 130A PG 1 WC Hematology SC Hematology GA 218CA UT WOS:000324409000286 ER PT J AU Billeter, SA Colton, L Sangmaneedet, S Suksawat, F Evans, BP Kosoy, MY AF Billeter, Sarah A. Colton, Leah Sangmaneedet, Somboon Suksawat, Fanan Evans, Brian P. Kosoy, Michael Y. TI Short Report: Molecular Detection and Identification of Bartonella Species, in Rat Fleas from Northeastern Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PREVALENCE; RICKETTSIA; RODENTS; CATS; DOGS; DNA; ECTOPARASITES; ANAPLASMA; EHRLICHIA; BANGKOK AB The presence of Bartonella species in Xenopsylla cheopis fleas collected from Rattus spp. (R. exulans;. R. norvegicus, and R. rattus) in Khon Kaen Province, Thailand was investigated. One hundred ninety-three fleas obtained from 62 rats, were screened by polymerase chain reaction using primers specific for the 16S-23S,intergenic spacer region, and the presence of Bartonella DNA was confirmed by using the citrate synthase gene. Bartonella DNA: was detected in 59.1%,(114 of 193) of fleas examined. Sequencing demonstrated the presence of Bartonella spp. similar to B. elizabethae, B. rattimassiliensis, B. rochalimae, and B. tribocorum in the samples tested with a cutoff for sequence similarity >= 96% and 4 clustered together with the closest match with B. grahamii (95.5% identity). If X. cheopis proves to be a competent vector of these species, our results suggest that humans and animals residing in this area may be at risk for infection by several zoonotic Bartonella species. C1 [Billeter, Sarah A.; Colton, Leah; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Sangmaneedet, Somboon; Suksawat, Fanan] Khon Kaen Univ, Fac Vet Med, Khon Kaen, Thailand. [Evans, Brian P.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Kosoy, MY (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM ina8@cdc.gov; ant6@cdc.gov; sombn_sa@kku.ac.th; jsvetmed@yahoo.com; brian.patrick.evans@us.army.mil; mck3@cdc.gov FU American Society of Tropical Medicine and Hygiene Robert E. Shope International Fellowship FX This study was supported by an American Society of Tropical Medicine and Hygiene Robert E. Shope International Fellowship to Sarah A. Billeter. NR 26 TC 5 Z9 5 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2013 VL 89 IS 3 BP 462 EP 465 DI 10.4269/ajtmh.12-0483 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 240XB UT WOS:000326129900011 PM 23836577 ER PT J AU Cohen, R Feghali, K Alemayehu, S Komisar, J Hang, J Weina, PJ Coggeshall, P Kamau, E Zapor, M AF Cohen, Robert Feghali, Karla Alemayehu, Saba Komisar, Jack Hang, Jun Weina, Peter J. Coggeshall, Patricia Kamau, Edwin Zapor, Michael TI Use of qPCR and Genomic Sequencing to Diagnose Plasmodium ovale wallikeri Malaria in a Returned Soldier in the Setting of a Negative Rapid Diagnostic Assay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TIME PCR ASSAY; VIVAX; FALCIPARUM; BINAX; PLDH AB Plasmodium ovale is one of several clinically relevant malaria species known to cause disease in humans. However, in contrast to Plasmodium falciparum and Plasmodium vivax, which are responsible for most cases of human malaria, P. ovule has a wide distribution but low prevalence in tropical regions. Here, we report the case of a soldier returning from Liberia with P. ovale wallikeri malaria. This case highlights the limitations of both microscopy and the malaria rapid diagnostic test for diagnosing infection with P. ovale and for distinguishing P. ovale wallikeri from P. ovale curtisi. To our knowledge, this is the first case report in which quantitative real-time polymerase chain reaction amplification using the Cytochrome B gene, coupled with genomic sequencing of the potra locus, was used for definitive diagnosis of P. ovale wallikeri malaria. C1 [Cohen, Robert] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Feghali, Karla; Alemayehu, Saba; Komisar, Jack] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Hang, Jun] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Weina, Peter J.; Kamau, Edwin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Coggeshall, Patricia] Walter Reed Natl Mil Med Ctr, Dept Pathol, Parasitol Sect, Bethesda, MD USA. [Zapor, Michael] Walter Reed Natl Mil Med Ctr, Dept Med, Infect Dis Serv, Bethesda, MD USA. RP Zapor, M (reprint author), 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM cohen.robbie@gmail.com; Karla.C.Feghali.ctr@us.army.mil; Saba.Alemayehu.ctr@us.army.mil; Jack.Komisar@us.army.mil; Jun.Hang.ctr@us.army.mil; peter.weina@us.army.mil; Patricia.A.Coggeshall.civ@health.mil; edwin.kamau@us.army.mil; Michael.J.Zapor.mil@health.mil RI Weina, Peter/A-2120-2011 NR 28 TC 5 Z9 5 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2013 VL 89 IS 3 BP 501 EP 506 DI 10.4269/ajtmh.12-0724 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 240XB UT WOS:000326129900018 PM 23836567 ER PT J AU Sosa, N Capitan, Z Nieto, J Nieto, M Calzada, J Paz, H Spadafora, C Kreishman-Deitrick, M Kopydlowski, K Ullman, D McCarthy, WF Ransom, J Berman, J Scott, C Grogl, M AF Sosa, Nestor Capitan, Zeuz Nieto, Javier Nieto, Melissa Calzada, Jose Paz, Hector Spadafora, Carmenza Kreishman-Deitrick, Mara Kopydlowski, Karen Ullman, Diane McCarthy, William F. Ransom, Janet Berman, Jonathan Scott, Charles Grogl, Max TI Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; TOPICAL TREATMENT; TH1 RESPONSE; BALB/C MICE; OINTMENT; ALLOPURINOL; DIAGNOSIS; PRESSURE; SOLDIERS; TABLES AB In this randomized, double-blinded Phase 2 trial, 30 patients with,Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Paromomycin Alone (P = 0.099). When all treated lesions were included, the final cure rate for WR 279,398-treated patients was again 87%, but the final cure rate for Paromomycin Alone-treated patients was 8 of 15 (53.3%; P = 0.046). Both creams were well tolerated with mild application site reactions being the most frequent adverse event. The increased final cure rate in the WR 279,396 group in this small Phase 2 study suggests that the combination product may provide greater clinical benefit than paromomycin monotherapy against L. panamensis cutaneous leishmaniasis. C1 Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. Inst Invest Cient & Serv Alta Tecnol, City Of Knowledge, Panama. USAMMDA, Ft Detrick, MD USA. Fast Track Drugs & Biol, North Potomac, MD USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Grogl, M (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM max.grogl@gmail.com OI Spadafora, Carmenza/0000-0002-3002-9467 FU U.S. Army Medical Materiel Development Activity, U.S. Army Medical Research and Materiel Command FX This study was funded by the U.S. Army Medical Materiel Development Activity, U.S. Army Medical Research and Materiel Command. NR 29 TC 14 Z9 14 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2013 VL 89 IS 3 BP 557 EP 563 DI 10.4269/ajtmh.12-0736 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 240XB UT WOS:000326129900029 PM 23857024 ER PT J AU Rastogi, VK Smith, LS Wallace, L Tomasino, SF AF Rastogi, Vipin K. Smith, Lisa S. Wallace, Lalena Tomasino, Stephen F. TI Modified AOAC Three Step Method (Official Method 2008.05): Consolidation of Fractions B and C SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID QUANTITATIVE 3-STEP METHOD; BACILLUS-SUBTILIS; LIQUID SPORICIDES; NONPOROUS SURFACE; EFFICACY; SPORES; HARD AB The AOAC Quantitative Three Step Method (TSM; AOAC Official Method(sm) 2008.05) is validated for testing the efficacy of liquid sporicides against spores of Bacillus sub tills and Bacillus anthracis on selected hard, nonporous, and porous surfaces. The TSM uses 5x5x1 mm inoculated coupons (carriers), which are placed in 400 mu L. liquid sporicidal agent contained in a microcentrifuge tube. Following exposure of inoculated carriers to the test chemical and subsequent neutralization, viable spores are recovered in three fractions: A (gentle tapping), B (sonication), and C (gentle agitation). The spores in suspension are serially diluted and plated on a recovery medium for enumeration. The plate counts are summed over the three fractions to provide the number of viable spores per carrier, which is log(10)-transformed to generate a mean log density (LD) value across carriers. As a measure of product efficacy, a log reduction (LR) value is calculated by subtracting the mean LD for treated carriers from the mean LD for control carriers. This paper reports on the comparative evaluation of the current and modified versions of the TSM in order to support a modification to simplify the procedure. The proposed modified TSM (mTSM) consolidates fractions B and C in the same tube. Thus, the sonication (fraction B) and gentle agitation (fraction C) steps are carried out in the same tube, thereby reducing the number of tubes and associated resources and time necessary to complete the test. Glass, steel, pine wood, and ceramic tile carriers were included in the comparative study. Inoculated carriers were evaluated against two preparations of sodium hypochlorite to generate two presumed levels of efficacy (intermediate and high); the control LD and LR values associated with testing each carrier type for the TSM and the mTSM were compared. For control carriers, the mean log densities per carrier (for each carrier material) were not significantly different based on the TSM compared to the mTSM. Furthermore, the treated carrier data showed comparable LR values for the TSM and mTSM. The data provided in this report demonstrate equivalency between the TSM and mTSM and support the proposed procedural modification to consolidate fractions B and C. C1 [Rastogi, Vipin K.; Smith, Lisa S.] US Army, Edgewood Chem Biol Ctr, BioDef Team, R&T Directorate, Aberdeen Proving Ground, MD 21010 USA. [Wallace, Lalena] Def Threat Reduct Agcy, Aberdeen Proving Ground, MD 21010 USA. [Tomasino, Stephen F.] US EPA, Off Pesticide Programs, Microbiol Lab Branch, Ctr Environm Sci, Ft George G Meade, MD 20755 USA. RP Tomasino, SF (reprint author), US EPA, Off Pesticide Programs, Microbiol Lab Branch, Ctr Environm Sci, Ft George G Meade, MD 20755 USA. EM Tomasino.Stephen@epamail.epa.gov FU U.S. EPA Office of Pesticide Programs FX Funding for this project was provided by the U.S. EPA Office of Pesticide Programs through an Interagency Agreement with the U.S. Army Edgewood Chemical Biological Center, Aberdeen, MD. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD SEP-OCT PY 2013 VL 96 IS 5 BP 947 EP 950 DI 10.5740/jaoacint:13-031 PG 4 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA 241WE UT WOS:000326198600004 PM 24282930 ER PT J AU Houston, JR Dean, RG AF Houston, J. R. Dean, R. G. TI Effects of Sea-Level Decadal Variability on Acceleration and Trend Difference SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Global change; sea level change ID TROPICAL PACIFIC; CIRCULATION; OCEAN; COAST AB Previous research has shown that sea-level acceleration determined from individual tide gauge records has remarkably large scatter as record lengths decrease due to decadal variations in sea level. We extend previous data sets to the present time and find even greater acceleration scatter. Using analytic solutions, sinusoidal oscillations with amplitudes and periods of typical decadal variations are shown to basically account for the relationship between record length and both acceleration and trend difference. Data show that decadal variations will obscure estimates of underlying accelerations if record lengths of individual gauges are not greater than at least 75 years. Although worldwide data are less affected by decadal variations than individual gauge data, decadal variations still significantly affect estimates of underlying accelerations, in particular for record lengths less than about 60 years. We give two examples of recent studies that use record lengths of about 30 to 60 years to determine acceleration or related trend difference. Previous authors dismissed the importance of decadal variations on their results and, as a result, reached invalid conclusions. C1 [Houston, J. R.] Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil; dean@coastal.ufl.edu NR 27 TC 8 Z9 8 U1 0 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD SEP PY 2013 VL 29 IS 5 BP 1062 EP 1072 DI 10.2112/JCOASTRES-D-12-00238.1 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 243GL UT WOS:000326304800008 ER PT J AU Kondor, S Grant, CAPTG Liacouras, P Schmid, MAJJR Parsons, LTCM Rastogi, VK Smith, LS Macy, B Sabart, B Macedonia, C AF Kondor, Shayne Grant, C. A. P. T. Gerald Liacouras, Peter Schmid, M. A. J. James R. Parsons, L. T. C. Michael Rastogi, Vipin K. Smith, Lisa S. Macy, Bill Sabart, Brian Macedonia, Christian TI On Demand Additive Manufacturing of a Basic Surgical Kit SO JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME LA English DT Article C1 [Kondor, Shayne; Grant, C. A. P. T. Gerald; Liacouras, Peter] Naval Postgrad Dent Sch, Bethesda, MD USA. [Schmid, M. A. J. James R.] Baylor Univ, US Army, Joint Base Lewis McChord, WA USA. [Rastogi, Vipin K.; Smith, Lisa S.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Macy, Bill; Sabart, Brian] Stratasys, Eden Prairie, MN USA. [Macedonia, Christian] Def Adv Res Projects Agcy, Arlington, VA USA. RP Kondor, S (reprint author), Naval Postgrad Dent Sch, Bethesda, MD USA. NR 2 TC 9 Z9 9 U1 0 U2 10 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1932-6181 EI 1932-619X J9 J MED DEVICES JI J. Med. Devices PD SEP PY 2013 VL 7 IS 3 AR UNSP 030916 DI 10.1115/1.4024490 PG 2 WC Engineering, Biomedical SC Engineering GA 240TF UT WOS:000326119200016 ER PT J AU Rastogi, VK Smith, L Schmid, JR Parsons, M Grant, G Kondor, S Macedonia, C AF Rastogi, Vipin K. Smith, Lisa Schmid, James R. Parsons, Mike Grant, Gerald Kondor, Shayne Macedonia, Chris TI A Novel Approach for Assured Sterility of Medical Devices SO JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME LA English DT Article C1 [Rastogi, Vipin K.; Smith, Lisa] US Army ECBC, Bio Def Branch, Biosci Div, R&T Directorate, Aberdeen Proving Ground, MD USA. [Schmid, James R.] Baylor Univ, US Army, Jblm, WA USA. [Grant, Gerald; Kondor, Shayne] Naval Postgrad Dent Sch, Bethesda, MD USA. [Macedonia, Chris] Def Adv Res Projects Agcy, Arlington, VA USA. RP Rastogi, VK (reprint author), US Army ECBC, Bio Def Branch, Biosci Div, R&T Directorate, Aberdeen Proving Ground, MD USA. NR 2 TC 3 Z9 3 U1 0 U2 1 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1932-6181 EI 1932-619X J9 J MED DEVICES JI J. Med. Devices PD SEP PY 2013 VL 7 IS 3 AR UNSP 030947 DI 10.1115/1.4024521 PG 2 WC Engineering, Biomedical SC Engineering GA 240TF UT WOS:000326119200047 ER PT J AU Holley, MAB Petteys, S Mitchell, JD Holley, PR Collen, JF AF Holley, Maj (P) Aaron B. Petteys, Sarah Mitchell, Joshua D. Holley, Paul R. Collen, Jacob F. TI Thromboprophylaxis and VTE Rates in Soldiers Wounded in Operation Enduring Freedom and Operation Iraqi Freedom SO CHEST LA English DT Article ID MOLECULAR-WEIGHT HEPARIN; DEEP VENOUS THROMBOSIS; TRAUMATIC BRAIN-INJURY; THROMBOEMBOLISM PROPHYLAXIS; PULMONARY-EMBOLISM; VEIN THROMBOSIS; MAJOR TRAUMA; PHARMACOLOGICAL PROPHYLAXIS; INTRACRANIAL HEMORRHAGE; UNFRACTIONATED HEPARIN AB Objectives: US soldiers suffer catastrophic injuries during combat. We sought to define risk factors and rates for VTE in this population. Methods: We gathered data each hospital day on all patients injured in Afghanistan or Iraq who were admitted to the Walter Reed Army Medical Center (WRAMC). We analyzed prophylaxis rates and efficacy and identified risk factors for VTE. Results: We recorded data on 506 combat casualties directly admitted to WRAMC after medical air evacuation. The average injury severity score for the group was 18.4 +/- 11.7, and the most common reason for air evacuation was injury by improvised explosive device (65%). As part of the initial resuscitation, patients received 4.7 +/- 9.0 and 4.00 +/- 7.8 units of packed RBCs and fresh frozen plasma, respectively, and 42 patients received factor VIIa. Forty-six patients (9.1%) were given a diagnosis of VTE prior to discharge, 18 (3.6%) during air evacuation, and 28 (5.5%) during the hospital stay. In Cox regression analysis, administration of 1 unit of packed RBCs was associated with a hazard ratio (HR) of 1.04 (95% CI, 1.02-1.07; P = .002), and enoxaparin, 30 mg bid, administered subcutaneously for the majority of hospital days was associated with a HR of 0.31 (95% CI, 0.11-0.86; P = .02) for VTE during the hospitalization. Conclusions: Patients who suffer traumatic injuries in combat overseas are at high risk for VTE during evacuation and recovery. Those with large resuscitations are at particularly high risk, and low-molecular-weight heparin is associated with a decrease in VTE. C1 [Holley, Maj (P) Aaron B.; Collen, Jacob F.] Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, Bethesda, MD 20889 USA. [Petteys, Sarah; Mitchell, Joshua D.] Walter Reed Natl Mil Med Ctr, Dept Internal Med, Bethesda, MD 20889 USA. [Holley, Paul R.] US Army Med Res Inst Infect Dis, Dept Informat, Frederick, MD USA. RP Holley, MAB (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM aholley9@gmail.com NR 41 TC 8 Z9 9 U1 1 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2013 VL 144 IS 3 BP 966 EP 973 DI 10.1378/chest.12-2879 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 241JC UT WOS:000326161700035 ER PT J AU Hope, ME Westerink, JJ Kennedy, AB Kerr, PC Dietrich, JC Dawson, C Bender, CJ Smith, JM Jensen, RE Zijlema, M Holthuijsen, LH Luettich, RA Powell, MD Cardone, VJ Cox, AT Pourtaheri, H Roberts, HJ Atkinson, JH Tanaka, S Westerink, HJ Westerink, LG AF Hope, M. E. Westerink, J. J. Kennedy, A. B. Kerr, P. C. Dietrich, J. C. Dawson, C. Bender, C. J. Smith, J. M. Jensen, R. E. Zijlema, M. Holthuijsen, L. H. Luettich, R. A., Jr. Powell, M. D. Cardone, V. J. Cox, A. T. Pourtaheri, H. Roberts, H. J. Atkinson, J. H. Tanaka, S. Westerink, H. J. Westerink, L. G. TI Hindcast and validation of Hurricane Ike (2008) waves, forerunner, and storm surge SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE Hurricane Ike; Louisiana-Texas shelf; storm surge; waves; hurricane forerunner; SWAN plus ADCIRC ID SHALLOW-WATER; SOUTHERN LOUISIANA; COASTAL REGIONS; WIND FIELDS; MODEL; SWAN; VERIFICATION; PERFORMANCE; GUSTAV; SCALE AB Hurricane Ike (2008) made landfall near Galveston, Texas, as a moderate intensity storm. Its large wind field in conjunction with the Louisiana-Texas coastline's broad shelf and large scale concave geometry generated waves and surge that impacted over 1000 km of coastline. Ike's complex and varied wave and surge response physics included: the capture of surge by the protruding Mississippi River Delta; the strong influence of wave radiation stress gradients on the Delta adjacent to the shelf break; the development of strong wind driven shore-parallel currents and the associated geostrophic setup; the forced early rise of water in coastal bays and lakes facilitating inland surge penetration; the propagation of a free wave along the southern Texas shelf; shore-normal peak wind-driven surge; and resonant and reflected long waves across a wide continental shelf. Preexisting and rapidly deployed instrumentation provided the most comprehensive hurricane response data of any previous hurricane. More than 94 wave parameter time histories, 523 water level time histories, and 206 high water marks were collected throughout the Gulf in deep water, along the nearshore, and up to 65 km inland. Ike's highly varied physics were simulated using SWAN+ADCIRC, a tightly coupled wave and circulation model, on SL18TX33, a new unstructured mesh of the Gulf of Mexico, Caribbean Sea, and western Atlantic Ocean with high resolution of the Gulf's coastal floodplain from Alabama to the Texas-Mexico border. A comprehensive validation was made of the model's ability to capture the varied physics in the system. C1 [Hope, M. E.; Westerink, J. J.; Kennedy, A. B.; Kerr, P. C.; Dietrich, J. C.; Tanaka, S.; Westerink, H. J.; Westerink, L. G.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Bender, C. J.] Taylor Engn, Jacksonville, FL USA. [Smith, J. M.; Jensen, R. E.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Zijlema, M.; Holthuijsen, L. H.] Delft Univ Technol, Fac Civil Engn & Geosci, Delft, Netherlands. [Luettich, R. A., Jr.] Univ N Carolina, Inst Marine Sci, Chapel Hill, NC USA. [Powell, M. D.] NOAA Miami, Atlantic Oceanog & Meteorol Labs, Hurricane Res Div, Miami, FL USA. [Cardone, V. J.; Cox, A. T.] Oceanweather Inc, Cos Cob, CT USA. [Pourtaheri, H.] US Army Corps Engineers, New Orleans Dist, New Orleans, LA USA. [Roberts, H. J.; Atkinson, J. H.] ARCADIS, Boulder, CO USA. RP Hope, ME (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM mark.e.hope@gmail.com RI Dietrich, Joel/E-5161-2011; Kennedy, Andrew/E-4746-2011; Zijlema, Marcel/J-3099-2013; Powell, Mark/I-4963-2013 OI Dietrich, Joel/0000-0001-5294-2874; Kennedy, Andrew/0000-0002-7254-1346; Powell, Mark/0000-0002-4890-8945 FU NOAA via the U.S. IOOS Office [NA10NOS0120063, NA11NOS0120141]; U.S. Army Corps of Engineers New Orleans District; Department of Homeland Security [2008-ST-061-ND0001]; Federal Emergency Management Agency, Region 6; National Science Foundation [OCI-0746232, OCI-1053575] FX This project was supported by: NOAA via the U.S. IOOS Office (NA10NOS0120063 and NA11NOS0120141) and was managed by the Southeastern Universities Research Association; the U.S. Army Corps of Engineers New Orleans District; the Department of Homeland Security (2008-ST-061-ND0001); and the Federal Emergency Management Agency, Region 6. The National Science Foundation (OCI-0746232) supported ADCIRC and SWAN model development. Computational facilities were provided by: the U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center; The University of Texas at Austin Texas Advanced Computing Center; The Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation, grant OCI-1053575. Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corps of Engineers. The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Homeland Security. The authors thank Professor Chunyan Li and the Coastal Studies Institute at Louisiana State University for providing the CSI water level and current data. NR 53 TC 26 Z9 26 U1 1 U2 29 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD SEP PY 2013 VL 118 IS 9 BP 4424 EP 4460 DI 10.1002/jgrc.20314 PG 37 WC Oceanography SC Oceanography GA 242HQ UT WOS:000326230200029 ER PT J AU Zhao, L Choi, KK Lee, I Gorsich, D AF Zhao, Liang Choi, K. K. Lee, Ikjin Gorsich, David TI Conservative Surrogate Model Using Weighted Kriging Variance for Sampling-Based RBDO SO JOURNAL OF MECHANICAL DESIGN LA English DT Article DE reliability-based design optimization (RBDO); limited number of samplings; conservative surrogate model; dynamic Kriging method; weighted Kriging variance; corrected Akaike Information Criterion (AICc) ID SUPPORT VECTOR MACHINE; CROSS-VALIDATION; SENSITIVITY-ANALYSIS; DESIGN; OPTIMIZATION; REGRESSION; SELECTION AB In sampling-based reliability-based design optimization (RBDO) of large-scale engineering applications, the Monte Carlo simulation (MCS) is often used for the probability of failure calculation and probabilistic sensitivity analysis using the prediction from the surrogate model for the performance function evaluations. When the number of samples used to construct the surrogate model is not enough, the prediction from the surrogate model becomes inaccurate and thus the Monte Carlo simulation results as well. Therefore, to count in the prediction error from the surrogate model and assure the obtained optimum design from sampling-based RBDO satisfies the probabilistic constraints, a conservative surrogate model, which is not overly conservative, needs to be developed. In this paper, a conservative surrogate model is constructed using the weighted Kriging variance where the weight is determined by the relative change in the corrected Akaike Information Criterion (AICc) of the dynamic Kriging model. The proposed conservative surrogate model performs better than the traditional Kriging prediction interval approach because it reduces fluctuation in the Kriging prediction bound and it performs better than the constant safety margin approach because it adaptively accounts large uncertainty of the surrogate model in the region where samples are sparse. Numerical examples show that using the proposed conservative surrogate model for sampling-based RBDO is necessary to have confidence that the optimum design satisfies the probabilistic constraints when the number of samples is limited, while it does not lead to overly conservative designs like the constant safety margin approach. C1 [Zhao, Liang] Schlumberger, Houston, TX 77073 USA. [Choi, K. K.] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Gorsich, David] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM lzhao01@slb.com; kkchoi@engineering.uiowa.edu; ilee@engr.uconn.edu; gorsichd@tacom.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU ARO [W911NF-09-1-0250]; Automotive Research Center; U.S. Army TARDEC; World Class University Program through the National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX The research is jointly supported by ARO Project No. W911NF-09-1-0250 and the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. These supports are greatly appreciated. This research was also partially supported by the World Class University Program through the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant No. R32-2008-000-10161-0 in 2009). NR 38 TC 1 Z9 1 U1 2 U2 15 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD SEP PY 2013 VL 135 IS 9 AR 091003 DI 10.1115/1.4024731 PG 10 WC Engineering, Mechanical SC Engineering GA 241MX UT WOS:000326172400004 ER PT J AU Chao, NH Dispenza, JA DeAngelis, M AF Chao, Nien-Hua Dispenza, John A. DeAngelis, Mario TI Advanced Methodologies for Developing Improved Potted Smart Munitions for High-G Applications SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article AB Potted electronics are becoming more common in precision-guided smart munitions designs due to the requirements for miniaturization and structural-robustness. In most of these applications, the potted electronics are inactive for most of their lifetime and may be stored without environmental (temperature and humidity) controls for up to 20 yr. The uncontrolled environment for smart munitions however makes the thermal management task especially difficult due to the coefficient of thermal expansion (CTE) mismatch that can exist between the potting material and the electronic components. In this paper, we will do the following: (1) present a methodology being developed for reducing the thermal stresses to the potted electronics used in uncontrolled environments by encapsulating the circuit board assembly (CBA) with a thin polymer layer which has been precisely formed to conform to the imprecisely shaped, as-populated, CBA. The protective polymer layer will be both flexible and soft enough to protect the CBA components from damage caused by thermal expansion mismatches, but not degrade the structural support that the potting provides during high-g force projectile launches, (2) discuss how the protective polymer layer methodology can also be used to lessen in-circuit board crosstalk, improve shielding from external RF interference, control tin-whisker growth, and enhance moisture barrier properties and thermal management for CBAs, and (3) demonstrate how to improve the smart munitions survivability under extreme high-g applications through the use of syntactic foams and material characterization before and after accelerated temperature-cycling and thermal-aging tests. C1 [Chao, Nien-Hua; DeAngelis, Mario] US Army, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Dispenza, John A.] Design Results LLC, Long Valley, NJ 07853 USA. RP Chao, NH (reprint author), US Army, ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 41 TC 0 Z9 0 U1 3 U2 10 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 EI 1528-9044 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD SEP PY 2013 VL 135 IS 3 AR 031002 DI 10.1115/1.4024301 PG 14 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA 240KW UT WOS:000326095800011 ER PT J AU Shaha, JS Cook, JB Rowles, DJ Bottoni, CR Shaha, SH Tokish, JM AF Shaha, James S. Cook, Jay B. Rowles, Douglas J. Bottoni, Craig R. Shaha, Steven H. Tokish, John M. TI Return to an Athletic Lifestyle After Osteochondral Allograft Transplantation of the Knee SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE osteochondral; allograft; activity; transplantation; chondral ID ARTICULAR-CARTILAGE REPAIR; TERM-FOLLOW-UP; FEMORAL CONDYLE; MICROFRACTURE TECHNIQUE; SOCCER PLAYERS; DEFECTS; DISSECANS; SCORE AB Background: Osteochondral allograft transplantation (OATS) is a treatment option that provides the ability to restore large areas of hyaline cartilage anatomy and structure without donor site morbidity and promising results have been reported in returning patients to some previous activities. However, no study has reported on the durability of return to activity in a setting where it is an occupational requirement. Hypothesis: Osteochondral allograft transplantation is less successful in returning patients to activity in a population in which physical fitness is a job requirement as opposed to a recreational goal. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review was conducted of 38 consecutive OATS procedures performed at a single military institution by 1 of 4 sports medicine fellowship-trained orthopaedic surgeons. All patients were on active duty at the time of the index procedure, and data were collected on demographics, return to duty, Knee Injury and Osteoarthritis Outcome Score (KOOS), and ultimate effect on military duty. Success was defined as the ability to return to the preinjury military occupational specialty (MOS) with no duty-limiting restrictions. Results: The mean lesion size treated was 487.0 178.7 mm(2). The overall rate of return to full duty was 28.9% (11/38). An additional 28.9% (11/38) were able to return to limited activity with permanent duty modifications. An alarming 42.1% (16/38) were unable to return to military activity because of their operative knee. When analyzed for return to sport, only 5.3% (2/38) of patients were able to return to their preinjury level. Eleven patients underwent concomitant procedures. Statistical power was maintained by analyzing data in aggregate for cases with versus without concomitant procedures. When the 11 undergoing concomitant procedures were removed from the data set, the rate of return to full activity was 33.3% (9/27), with 22.3% (6/27) returning to limited activity and 44.4% (12/27) unable to return to activity. In this subset, 7.4% (2/27) were able to return to a preinjury level of sport. The KOOS values were significantly higher in the full activity group when compared with the limited and no activity groups (P < .01). Branch of service was a significant predictor of outcome, with Marine Corps and Navy service members more likely to return to full activity compared with Army and Air Force members. A MOS of combat arms was a significant predictor of a poor outcome. All patients demonstrated postoperative healing of their grafts as documented in their medical chart, and no patient in the series required revision for problems with graft incorporation. Conclusion: Osteochondral allograft transplantation for the treatment of large chondral defects in the knee met with disappointing results in an active-duty population and was even less reliable in returning this population to preinjury sport levels. Branch of service and occupational type predicted the return to duty, but other traditional predictors of outcome such as rank and years of service did not. The presence of concomitant procedures did not have an effect on outcome with respect to activity or sport level with the numbers available for analysis. C1 [Shaha, James S.; Cook, Jay B.; Rowles, Douglas J.; Bottoni, Craig R.; Shaha, Steven H.; Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Shaha, JS (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jshaha6@gmail.com NR 25 TC 9 Z9 9 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2013 VL 41 IS 9 BP 2083 EP 2089 DI 10.1177/0363546513494355 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 235JK UT WOS:000325714200016 PM 23841992 ER PT J AU Svoboda, SJ Harvey, TM Owens, BD Brechue, WF Tarwater, PM Cameron, KL AF Svoboda, Steven J. Harvey, Travis M. Owens, Brett D. Brechue, William F. Tarwater, Patrick M. Cameron, Kenneth L. TI Changes in Serum Biomarkers of Cartilage Turnover After Anterior Cruciate Ligament Injury SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE cartilage turnover; cartilage metabolism; ACL injury; biomarkers; posttraumatic osteoarthritis ID KNEE OSTEOARTHRITIS; II COLLAGEN; ARTICULAR-CARTILAGE; RISK-FACTORS; PROTEOGLYCAN AGGRECAN; BIOCHEMICAL MARKERS; HIP-OSTEOARTHRITIS; ASSOCIATION; POPULATION; EPIDEMIOLOGY AB Background: Biomarkers of cartilage turnover and joint metabolism have a potential use in detecting early degenerative changes after a traumatic knee joint injury; however, no study has analyzed biomarkers before an anterior cruciate ligament (ACL) injury and again after injury or in comparison with a similar group of uninjured controls. Hypothesis: Changes in serum biomarker levels and the ratio of cartilage degradation to synthesis, from baseline to follow-up, would be significantly different between ACL-injured patients and uninjured controls. Study Design: Case-control study; Level of evidence, 3. Methods: This case-control study was conducted to examine changes in serum biomarkers of cartilage turnover following ACL injury in a young athletic population. Specifically, 2 markers for type II collagen and aggrecan synthesis (CPII and CS846, respectively) and 2 markers of types I and II degradation and type II degradation only (C1,2C and C2C, respectively) were studied. Preinjury baseline serum samples and postinjury follow-up samples were obtained for 45 ACL-injured cases and 45 uninjured controls matched for sex, age, height, and weight. Results: Results revealed significant decreases in C1,2C (P = .042) and C2C (P = .006) over time in the ACL-injured group when compared with the controls. The change in serum concentrations of CS846 from baseline to follow-up was also significantly different between the ACL-injured patients and uninjured controls (P = .002), as was the change between groups in the ratio of C2C:CPII over time (P = .013). No preinjury differences in the ratio of C1,2C:CPII or C2C:CPII were observed between groups; however, postinjury differences were observed for both ratios. Conclusion: Changes in biomarker concentrations after an ACL injury suggest an alteration in cartilage turnover and joint metabolism in those sustaining ACL injuries compared with uninjured matched controls. C1 [Svoboda, Steven J.; Harvey, Travis M.; Owens, Brett D.; Brechue, William F.; Tarwater, Patrick M.; Cameron, Kenneth L.] Keller Army Hosp, West Point, NY 10996 USA. RP Cameron, KL (reprint author), Keller Army Hosp, Dept Orthoped Surg, 900 Washington Rd, West Point, NY 10996 USA. EM kenneth.l.cameron.civ@mail.mil OI Cameron, Kenneth/0000-0002-6276-4482 FU Orthopaedic Research and Education Foundation FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study was aided by a grant from the Orthopaedic Research and Education Foundation. NR 46 TC 13 Z9 13 U1 1 U2 13 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2013 VL 41 IS 9 BP 2108 EP 2116 DI 10.1177/0363546513494180 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 235JK UT WOS:000325714200019 PM 23831890 ER PT J AU Cozza, SJ Lerner, RM AF Cozza, Stephen J. Lerner, Richard M. TI Military Children and Families: Introducing the Issue SO FUTURE OF CHILDREN LA English DT Editorial Material C1 [Cozza, Stephen J.] US Army, Adelphi, MD USA. [Cozza, Stephen J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Lerner, Richard M.] Tufts Univ, Inst Appl Res Youth Dev, Medford, MA USA. NR 9 TC 7 Z9 7 U1 0 U2 6 PU PRINCETON UNIV PI PRINCETON PA 277 WALLACE HALL, PRINCETON, NJ 08544 USA SN 1054-8289 EI 1550-1558 J9 FUTURE CHILD JI Future Child. PD FAL PY 2013 VL 23 IS 2 BP 3 EP 11 PG 9 WC Family Studies; Health Policy & Services; Social Sciences, Interdisciplinary SC Family Studies; Health Care Sciences & Services; Social Sciences - Other Topics GA 230FR UT WOS:000325322600001 PM 25518689 ER PT J AU Floyd, ML Phillips, DA AF Floyd, Major Latosha Phillips, Deborah A. TI Child Care and Other Support Programs SO FUTURE OF CHILDREN LA English DT Article ID MILITARY FAMILIES; ADJUSTMENT; COMBAT AB The U. S. military has come to realize that providing reliable, high-quality child care for service members' children is a key component of combat readiness. As a result, the Department of Defense (DoD) has invested heavily in child care. The DoD now runs what is by far the nation's largest employer-sponsored child-care system, a sprawling network with nearly 23,000 workers that directly serves or subsidizes care for 200,000 children every day. Child-care options available to civilians typically pale in comparison, and the military's system, embedded in a broader web of family support services, is widely considered to be a model for the nation. The military's child-care success rests on four pillars, write Major Latosha Floyd and Deborah A. Phillips. The first is certification by the military itself, including unannounced inspections to check on safety, sanitation, and general compliance with DoD rules. The second is accreditation by nationally recognized agencies, such as the National Association for the Education of Young Children. The third is a hiring policy that sets educational and other requirements for childcare workers, and the fourth is a pay scale that not only sets wages high enough to discourage the rapid turnover common in civilian child care but also rewards workers for completing additional training. Floyd and Phillips sound a few cautionary notes. For one, demand for military child care continues to outstrip the supply. In particular, as National Guard and Reserve members have been activated during the wars in Iraq and Afghanistan, the DoD has sometimes struggled to provide child care for their children. And force reductions and budget cuts are likely to force the military to make difficult choices as it seeks to streamline its child-care services in the years ahead. C1 [Floyd, Major Latosha] US Army, Adelphi, MD USA. [Phillips, Deborah A.] Georgetown Univ, Washington, DC 20057 USA. NR 46 TC 2 Z9 2 U1 1 U2 7 PU PRINCETON UNIV PI PRINCETON PA 277 WALLACE HALL, PRINCETON, NJ 08544 USA SN 1054-8289 EI 1550-1558 J9 FUTURE CHILD JI Future Child. PD FAL PY 2013 VL 23 IS 2 BP 79 EP 97 PG 19 WC Family Studies; Health Policy & Services; Social Sciences, Interdisciplinary SC Family Studies; Health Care Sciences & Services; Social Sciences - Other Topics GA 230FR UT WOS:000325322600005 PM 25518693 ER PT J AU Holmes, AK Rauch, PK Cozza, SJ AF Holmes, Allison K. Rauch, Paula K. Cozza, Stephen J. TI When a Parent Is Injured or Killed in Combat SO FUTURE OF CHILDREN LA English DT Article ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; BEREAVED CHILDREN; PSYCHOLOGICAL DISTRESS; PROVIDER PERSPECTIVES; VIETNAM VETERANS; TERM ADJUSTMENT; SERVICE MEMBERS; WAR VETERANS AB When a service member is injured or dies in a combat zone, the consequences for his or her family can be profound and long-lasting. Visible, physical battlefield injuries often require families to adapt to long and stressful rounds of treatment and rehabilitation, and they can leave the service member with permanent disabilities that mean new roles for everyone in the family. Invisible injuries, both physical and psychological, including traumatic brain injury and combat-related stress disorders, are often not diagnosed until many months after a service member returns from war (if they are diagnosed at all-many sufferers never seek treatment). They can alter a service member's behavior and personality in ways that make parenting difficult and reverberate throughout the family. And a parent's death in combat not only brings immediate grief but can also mean that survivors lose their very identity as a military family when they must move away from their supportive military community. Sifting through the evidence on both military and civilian families, Allison Holmes, Paula Rauch, and Stephen Cozza analyze, in turn, how visible injuries, traumatic brain injuries, stress disorders, and death affect parents' mental health, parenting capacity, and family organization; they also discuss the community resources that can help families in each situation. They note that most current services focus on the needs of injured service members rather than those of their families. Through seven concrete recommendations, they call for a greater emphasis on family-focused care that supports resilience and positive adaptation for all members of military families who are struggling with a service member's injury or death. C1 [Holmes, Allison K.; Cozza, Stephen J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Rauch, Paula K.] Massachusetts Gen Hosp Home Base Team, Boston, MA USA. [Rauch, Paula K.] Harvard Univ, Med School, Cambridge, MA 02138 USA. [Cozza, Stephen J.] US Army, Adelphi, MD USA. RP Holmes, AK (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. NR 82 TC 10 Z9 10 U1 2 U2 10 PU PRINCETON UNIV PI PRINCETON PA 277 WALLACE HALL, PRINCETON, NJ 08544 USA SN 1054-8289 EI 1550-1558 J9 FUTURE CHILD JI Future Child. PD FAL PY 2013 VL 23 IS 2 BP 143 EP 162 PG 20 WC Family Studies; Health Policy & Services; Social Sciences, Interdisciplinary SC Family Studies; Health Care Sciences & Services; Social Sciences - Other Topics GA 230FR UT WOS:000325322600008 PM 25518696 ER PT J AU Kudler, H Porter, RI AF Kudler, Harold Porter, Rebecca I. TI Building Communities of Care for Military Children and Families SO FUTURE OF CHILDREN LA English DT Article ID FACING WARTIME DEPLOYMENTS; CENTERED PREVENTION; RESILIENCE; STRESS; INTERVENTION; HEALTH AB Military children don't exist in a vacuum; rather, they are embedded in and deeply influenced by their families, neighborhoods, schools, the military itself, and many other interacting systems. To minimize the risks that military children face and maximize their resilience, write Harold Kudler and Colonel Rebecca Porter, we must go beyond clinical models that focus on military children as individuals and develop a public health approach that harnesses the strengths of the communities that surround them. In short, we must build communities of care. One obstacle to building communities of care is that at many times and in many places, military children and their families are essentially invisible. Most schools, for example, do not routinely assess the military status of new students' parents. Thus Kudler and Porter's strongest recommendation is that public and private institutions of all sorts-from schools to clinics to religious institutions to law enforcement-should determine which children and families they serve are connected to the military as a first step toward meeting military children's unique needs. Next, they say, we need policies that help teachers, doctors, pastors, and others who work with children learn more about military culture and the hardships, such as a parent's deployment, that military children often face. Kudler and Porter review a broad spectrum of programs that may help build communities of care, developed by the military, by nonprofits, and by academia. Many of these appear promising, but the authors emphasize that almost none are backed by strong scientific evidence of their effectiveness. They also describe new initiatives at the state and federal levels that aim to break down barriers among agencies and promote collaboration in the service of military children and families. C1 [Kudler, Harold] Duke Univ, Durham, NC 27706 USA. [Kudler, Harold] Midatlantic Hlth Care Network VISN 6, Dept Vet Affairs, Mental Illness Res Educ & Clin Ctr, Beltsville, MD USA. [Porter, Rebecca I.] Dunham Army Hlth Clin Carlisle Barracks, Carlisle, PA USA. [Porter, Rebecca I.] US Army, Behav Hlth Div, Off Surg General, Adelphi, MD USA. RP Kudler, H (reprint author), Duke Univ, Durham, NC 27706 USA. NR 35 TC 9 Z9 9 U1 0 U2 11 PU PRINCETON UNIV PI PRINCETON PA 277 WALLACE HALL, PRINCETON, NJ 08544 USA SN 1054-8289 EI 1550-1558 J9 FUTURE CHILD JI Future Child. PD FAL PY 2013 VL 23 IS 2 BP 163 EP 185 PG 23 WC Family Studies; Health Policy & Services; Social Sciences, Interdisciplinary SC Family Studies; Health Care Sciences & Services; Social Sciences - Other Topics GA 230FR UT WOS:000325322600009 PM 25518697 ER PT J AU Gates, DH Scott, SJ Wilken, JM Dingwell, JB AF Gates, Deanna H. Scott, Shawn J. Wilken, Jason M. Dingwell, Jonathan B. TI Frontal plane dynamic margins of stability in individuals with and without transtibial amputation walking on a loose rock surface SO GAIT & POSTURE LA English DT Article DE Gait; Amputation; Irregular surface; Lateral stability; Step width variability ID OLDER-ADULTS; RISK-FACTORS; GAIT CHARACTERISTICS; AMPUTEES; BALANCE; SPEED; FALLS; STRATEGIES AB Uneven walking surfaces pose challenges to balance, especially in individuals with lower extremity amputation. The purpose of this study was to determine if lateral stability of persons with unilateral transtibial amputation (TTA) is compromised when walking on a loose rock surface. Thirteen TTA and 15 healthy controls walked over level ground and over a loose rock surface at four controlled speeds. Dependent measures, including medial-lateral center of mass (COM) motion, step width variability, lateral arm swing velocity, and mean and variability of the minimum margins of stability (MOSmin), were compared between subject groups and across conditions. TTA had greater average MOSmin than Control subjects (p = 0.018). TTA exhibited decreased MOSmin on their prosthetic limbs compared to their intact limbs (p = 0.036), while Control subjects did not exhibit side to side differences. Both groups increased MOSmin with increasing walking speed (p <= 0.001). There was no difference in the average MOSmin between walking surfaces (p = 0.724). However, the variability of MOSmin was greater on the rocks compared to level ground. Both subject groups increased step width, step width variability, COM range of motion and peak COM velocity when walking on the rock surface. TTA exhibited greater variability of both step width and MOSmin, which suggests that they made larger step-to-step corrective responses, more often, to achieve the same average result. (c) 2013 Elsevier B.V. All rights reserved. C1 [Gates, Deanna H.; Wilken, Jason M.] San Antonio Mil Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Scott, Shawn J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Dingwell, JB (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. EM jdingwell@austin.utexas.edu OI Wilken, Jason/0000-0002-5556-7667; Dingwell, Jonathan/0000-0001-6990-4153 FU Military Amputee Research Program; US Army Medical Specialty Corps Long-Term Health Education Training Fellowship; NIH [1-R01-HD059844] FX Partial support was provided by the Military Amputee Research Program (to JMW), a US Army Medical Specialty Corps Long-Term Health Education Training Fellowship (to SJS), and NIH grant 1-R01-HD059844 (to JBD). We would like to thank Emily Sinitski and Jordan Sturdy for their help with data processing. NR 25 TC 17 Z9 17 U1 2 U2 51 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 EI 1879-2219 J9 GAIT POSTURE JI Gait Posture PD SEP PY 2013 VL 38 IS 4 BP 570 EP 575 DI 10.1016/j.gaitpost.2013.01.024 PG 6 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 231MV UT WOS:000325421900003 PM 23481866 ER PT J AU Prager, EM Aroniadou-Anderjaska, V Almeida-Suhett, CP Figueiredo, TH Apland, JP Braga, MFM AF Prager, Eric M. Aroniadou-Anderjaska, Vassiliki Almeida-Suhett, Camila P. Figueiredo, Taiza H. Apland, James P. Braga, Maria F. M. TI Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure SO NEUROTOXICOLOGY LA English DT Article DE Acetylcholinesterase; Soman; Status epilepticus; Basolateral amygdala; Piriform cortex; Hippocampus ID LIMBIC STATUS EPILEPTICUS; AGENT-INDUCED SEIZURE; CHOLINE-ACETYLTRANSFERASE; FUNCTIONAL-ANATOMY; RAT; NEUROPATHOLOGY; HIPPOCAMPUS; DIAZEPAM; EPILEPTOGENESIS; MICROINJECTION AB Exposure to nerve agents induces intense seizures (status epilepticus, SE), which cause brain damage or death. Identification of the brain regions that are critical for seizure initiation after nerve agent exposure, along with knowledge of the physiology of these regions, can facilitate the development of pretreatments and treatments that will successfully prevent or limit the development of seizures and brain damage. It is well-established that seizure initiation is due to excessive cholinergic activity triggered by the nerve agent-induced irreversible inhibition of acetylcholinesterase (AChE). Therefore, the reason that when animals are exposed to lethal doses of a nerve agent, a small proportion of these animals do not develop seizures, may have to do with failure of the nerve agent to inhibit AChE in brain areas that play a key role in seizure initiation and propagation. In the present study, we compared AChE activity in the basolateral amygdala (BLA), hippocampus, and piriform cortex of rats that developed SE (SE rats) after administration of the nerve agent soman (154 mu g/kg) to AChE activity in these brain regions of rats that received the same dose of soman but did not develop SE (no-SE rats). The levels of AChE activity were measured at the onset of SE in SE rats, 30 min after soman administration in no-SE rats, as well as in controls which received saline in place of soman. In the control group, AChE activity was significantly higher in the BLA compared to the hippocampus and piriform cortex. Compared to controls, AChE activity was dramatically lower in the hippocampus and the piriform cortex of both the SE rats and the no-SE rats, but AChE activity in the BLA was reduced only in the SE rats. Consistent with the notion that soman-induced neuropathology is due to intense seizures, rather than due to a direct neurotoxic effect of soman, no-SE rats did not present any neuronal loss or degeneration, 7 days after exposure. The results suggest that inhibition of AChE activity in the BLA is necessary for the generation of seizures after nerve agent exposure, and provide strong support to the view that the amygdala is a key brain region for the induction of seizures by nerve agents. Published by Elsevier Inc. C1 [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Figueiredo, Taiza H.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Program Neurosci, Bethesda, MD 20814 USA. [Apland, James P.] USA, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM maria.braga@usuhs.edu RI Prager, Eric/O-1567-2015 OI Prager, Eric/0000-0002-3810-0985 FU National Institute of Neurologic Disorders and Stroke [5U01N5058162-07]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.NEURO.01.10.US.18, CBM.NEURO.01.10.US.15]; CounterACT Program, National Institutes of Health, Office of the Director FX This work was supported by the CounterACT Program, National Institutes of Health, Office of the Director and the National Institute of Neurologic Disorders and Stroke [Grant Number 5U01N5058162-07], and the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division [Grant Numbers CBM.NEURO.01.10.US.18 and CBM.NEURO.01.10.US.15]. NR 37 TC 15 Z9 15 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD SEP PY 2013 VL 38 BP 84 EP 90 DI 10.1016/j.neuro.2013.06.006 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 231VZ UT WOS:000325447800012 PM 23817175 ER PT J AU West, D West, BJ AF West, D. West, B. J. TI Response to commentaries on "Physiologic time: A hypothesis" SO PHYSICS OF LIFE REVIEWS LA English DT Editorial Material ID ALLOMETRY; WEST C1 [West, D.] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. [West, B. J.] US Army, Informat Sci Directorate, Res Off, Res Triangle Pk, NC USA. RP West, BJ (reprint author), US Army, Informat Sci Directorate, Res Off, Res Triangle Pk, NC USA. EM bruce.j.west.civ@mail.mil NR 11 TC 0 Z9 0 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1571-0645 EI 1873-1457 J9 PHYS LIFE REV JI Phys. Life Rev. PD SEP PY 2013 VL 10 IS 3 BP 391 EP 393 DI 10.1016/j.plrev.2013.08.001 PG 3 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 231UW UT WOS:000325444900029 PM 23993639 ER PT J AU Banks, KP Song, WS AF Banks, Kevin P. Song, Won S. TI Role of Positron Emission Tomography-Computed Tomography in Gastrointestinal Malignancies SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Positron emission tomography-computed tomography; F-18-Fluorodeoxyglucose; Gastrointestinal malignancies; Neoadjuvant therapy ID SQUAMOUS-CELL CARCINOMA; COLORECTAL LIVER METASTASES; LYMPH-NODE METASTASIS; PAPILLARY MUCINOUS NEOPLASMS; COMBINED PET/CT PROTOCOLS; ENHANCED F-18-FDG PET/CT; PHASE-II TRIAL; ESOPHAGEAL CANCER; STROMAL TUMORS; FDG-PET AB Positron emission tomography (PET) has proved itself to be valuable in the evaluation of patients with a wide array of gastrointestinal (GI) malignancies. Subsequent development of fusion imaging with PET and computed tomography (PET-CT) scanners has significantly advanced the capabilities of imaging by combining the functional data of the F-18-labeled glucose analogue fluorodeoxyglucose (FDG) with the conventional anatomic data provided by CT. This article reviews the evolving role of FDG PET-CT imaging in the initial assessment and monitoring of GI tumors. Specific applications are discussed, and normal variants and benign findings frequently encountered during PET-CT of the GI tract are reviewed. C1 [Banks, Kevin P.; Song, Won S.] Brooke Army Med Ctr, San Antonio Hlth Care Syst, Dept Radiol, San Antonio, TX 78234 USA. [Banks, Kevin P.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Banks, Kevin P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 153 TC 0 Z9 0 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0033-8389 EI 1557-8275 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD SEP PY 2013 VL 51 IS 5 BP 799 EP + DI 10.1016/j.rcl.2013.05.003 PG 34 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 231TO UT WOS:000325441500003 PM 24010907 ER PT J AU Bryson, JS AF Bryson, Jennifer S. TI Silenced: How Apostasy and Blasphemy Codes are Choking Freedom Worldwide SO REVIEW OF FAITH & INTERNATIONAL AFFAIRS LA English DT Book Review DE Religious freedom; free speech; apostasy; blasphemy; defamation; hate speech; Islam; shari'a AB A review of Paul Marshall and Nina Shea, Silenced: How Apostasy and Blasphemy Codes are Choking Freedom Worldwide (New York: Oxford University Press, 2011), a book that examines the impact of apostasy and blasphemy laws on converts away from Islam, religious minorities, and Muslim intellectuals, and that also includes essays by three Muslim contributors who argue Islam itself does not require, or even support, the temporal punishments for apostasy and blasphemy. C1 [Bryson, Jennifer S.] US Army War Coll, Peacekeeping & Stabil Operat Inst, Carlisle, PA USA. RP Bryson, JS (reprint author), US Army War Coll, Peacekeeping & Stabil Operat Inst, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 1 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1557-0274 EI 1931-7743 J9 REV FAITH INT AFF JI Rev. Faith Int. Aff. PD SEP 1 PY 2013 VL 11 IS 3 BP 84 EP 85 DI 10.1080/15570274.2013.829986 PG 2 WC Religion SC Religion GA 217NN UT WOS:000324366300011 ER PT J AU Smith, DD Alexson, DA Garbini, JL AF Smith, Doran D. Alexson, Dimitri A. Garbini, Joseph L. TI A 4 K cryogenic probe for use in magnetic resonance force microscopy experiments SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID ANGULAR-MOMENTUM DETECTION; FIBEROPTIC INTERFEROMETER; PARAMAGNETIC RESONANCE; LOW FIELDS; DESIGN; CANTILEVERS; CONTACTS; SOLIDS AB The detailed design of a mechanically detected nuclear magnetic resonance probe using the SPAM (Springiness Preservation by Aligning Magnetization) geometry, operating at 4 K, in vacuum, and a several-Tesla magnetic field is described. The probe head is vibration-isolated well enough from the environment by a three-spring suspension system that the cantilever achieves thermal equilibrium with the environment without the aid of eddy current damping. The probe uses an ultra-soft Si cantilever with a Ni sphere attached to its tip, and magnetic resonance is registered as a change in the resonant frequency of the driven cantilever. The RF system uses frequency sweeps for adiabatic rapid passage using a 500 mu m diameter RF coil wound around a sapphire rod. The RF coil and optical fiber of the interferometer used to sense the cantilever's position are both located with respect to the cantilever using a Garbini micropositioner, and the sample stage is mounted on an Attocube nanopositioner. (C) 2013 AIP Publishing LLC. C1 [Smith, Doran D.; Alexson, Dimitri A.] US Army Res Lab, Adelphi, MD 20783 USA. [Garbini, Joseph L.] Univ Washington, Seattle, WA 98195 USA. RP Smith, DD (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM do-ran.d.smith.civ@mail.mil FU DOE Office of Defense Nuclear Nonproliferation RD FX We would like to thank Peter Newman for MBE growth of the GaAs sample used in this work, Steve Hickman and John Marohn of Cornell University for kindly supplying the cantilevers, Jeff Pulskamp for simulations of the vibrational modes of the main support tube (15) and its bottom (23), and Mathew Ervin for evaporating Ti and Au on the GaAs sample. D. D. S. would like to thank J.L.G. for kindly sharing the design for his micropositioner with them (which D. D. S. affectionately named, a "Garbini"). Partial funding of the work was provided by the DOE Office of Defense Nuclear Nonproliferation R&D, and Dr. Nicholas Fell and Dr. Parvez Uppal for their support. NR 46 TC 0 Z9 0 U1 2 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD SEP PY 2013 VL 84 IS 9 AR 095110 DI 10.1063/1.4820911 PG 13 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 231FX UT WOS:000325402000061 PM 24089869 ER PT J AU Holecek, DE Scarnecchia, DL AF Holecek, Dean E. Scarnecchia, Dennis L. TI Comparison of Two Life History Strategies after Impoundment of a Historically Anadromous Stock of Columbia River Redband Trout SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID RAINBOW-TROUT; SALMO-GAIRDNERI; ONCORHYNCHUS-MYKISS; DESERT STREAMS; FOOD-HABITS; IDAHO; POPULATION; RESIDENT; EXPLOITATION; MIGRATIONS AB In this study we collected information on abundance, age structure, migration, and exploitation to characterize the population demographics and reproductive characteristics of a historically anadromous Columbia River Redband Trout Oncorhynchus mykiss gairdneri population now isolated in a southwestern Idaho reservoir and limited to resident and adfluvial life histories. We estimated there were 3,905 adfluvial individuals in Mann Creek Reservoir in October 2008 based on a mark-recapture population estimate. The adfluvial population sex ratio of 2.78 females per male captured at a weir, peak spawn timing near the peak of the hydrograph (late April), age at spawning (4-6years), and growth patterns (slow growth in the stream followed by rapid growth in the reservoir) were all characteristic of an anadromous population. Resident fish abundance was not estimated, but the fish were characterized by relatively slow growth, earlier sexual maturity, and a reverse sex ratio (0.23 females per male) compared with the adfluvial fish. The two life histories (resident and adfluvial) and their differential use by the sexes are consistent with life history theory, which suggests female salmonids maximize fitness by increasing body size and fecundity while males attempt to maximize survival at the expense of growth. The migratory fish in this drainage that could have historically exercised an anadromous life history appear to be exercising the next-best option, an adfluvial life history, which has relatively similar costs and benefits to the anadromous form as distinct from the stream-resident form. Future studies should evaluate other similar native populations isolated in reservoir systems because these populations could play a role in recovery of endangered steelhead (anadromous Rainbow Trout) populations in the western USA. Received December 4, 2012; accepted April 18, 2013 C1 [Holecek, Dean E.; Scarnecchia, Dennis L.] Univ Idaho, Dept Fish & Wildlife Sci, Moscow, ID 83844 USA. RP Holecek, DE (reprint author), US Army Corps Engineers, 201 North 3rd St, Walla Walla, WA 99362 USA. EM dean.holecek@usace.army.mil FU Idaho Fish and Game through the Federal Aid in Sport Fish Restoration Program FX We are grateful for field and laboratory assistance from many people including R. Attebery, J. Kingsbury, S. Miller, J. Kozfkay, J. Dillon, D. Schill, T. Watson, L. Mamer, S. Elle, members of the Boise Valley Flyfishermen, the Indianhead Flyfishermen, and many Idaho Fish and Game personnel. This manuscript improved with reviews from R. Beamish and three anonymous reviewers. Funding was provided by the Idaho Fish and Game through the Federal Aid in Sport Fish Restoration Program. NR 58 TC 2 Z9 2 U1 3 U2 28 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD SEP 1 PY 2013 VL 142 IS 5 BP 1157 EP 1166 DI 10.1080/00028487.2013.799520 PG 10 WC Fisheries SC Fisheries GA 220VA UT WOS:000324613800001 ER PT J AU Heath, NM Lynch, SM Fritch, AM Wong, MM AF Heath, Nicole M. Lynch, Shannon M. Fritch, April M. Wong, Maria M. TI Rape Myth Acceptance Impacts the Reporting of Rape to the Police: A Study of Incarcerated Women SO VIOLENCE AGAINST WOMEN LA English DT Article DE rape myths; reporting; sexual assault ID SEXUAL ASSAULT; NATIONAL WOMENS; VICTIMIZATION; ATTRIBUTIONS; DISCLOSURE; VICTIMS; BLAME AB We examined the association between rape myth acceptance (RMA) and reporting rapes to the police. Situational characteristics of the rape (e.g., stranger attack, injury) are known predictors of reporting, but no existing studies have examined the association between beliefs about rape and reporting. In addition, most studies of RMA do not assess victimization history. Incarcerated women experience high rates of sexual assaults prior to incarceration. We recruited 74 rape survivors from a northwestern state prison. Results suggest that women who endorsed higher levels of RMA were less likely to report their rapes to police; however, participants endorsed few rape myths. C1 [Heath, Nicole M.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA. [Lynch, Shannon M.] Idaho State Univ, Pocatello, ID 83209 USA. [Wong, Maria M.] Idaho State Univ, Program Expt Psychol, Pocatello, ID 83209 USA. [Fritch, April M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Heath, NM (reprint author), Rush Univ, Med Ctr, Dept Behav Sci, 1645 W Jackson,Suite 400, Chicago, IL 60612 USA. EM Nicole_Heath@rush.edu NR 30 TC 3 Z9 4 U1 2 U2 16 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 EI 1552-8448 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD SEP PY 2013 VL 19 IS 9 BP 1065 EP 1078 DI 10.1177/1077801213501841 PG 14 WC Women's Studies SC Women's Studies GA 236LT UT WOS:000325799000002 PM 24142951 ER PT J AU Toole, JR Renbaum-Wolff, L Smith, GD AF Toole, Justin R. Renbaum-Wolff, Lindsay Smith, Geoffrey D. TI A Calibration Technique for Improving Refractive Index Retrieval from Aerosol Cavity Ring-Down Spectroscopy SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID ATMOSPHERIC PARTICULATE MATTER; OPTICAL-PROPERTIES; ABSORPTION-MEASUREMENTS; AMMONIUM-SULFATE; LIGHT-ABSORPTION; CLOUD DROPLETS; SOOT AEROSOL; SPECTROMETER; PARTICLES; EXTINCTION AB Cavity ring-down spectroscopy (CRDS) is a technique that is commonly used to measure the extinction of light by aerosol particles in situ. This extinction, when normalized to particle concentration, yields the extinction cross section, a measure of a single particle's ability to scatter and absorb light. The complex index of refraction can then be retrieved by comparison of the extinction cross sections at several particle diameters with those predicted by Mie theory. This approach requires accurate determination of particle diameter and concentration as well as the length of the extinction region in the cavity, but it is often difficult to quantify the systematic errors in the measurements of these quantities. Here, we introduce a calibration technique using particles of a reference compound to account for these systematic errors. The two calibration parameters are: C-f, which scales the measured extinction cross sections, and Delta d, which shifts the particle diameters. It is found that C-f correlates strongly with the condensation particle counter (CPC) used to measure particle concentration and that Delta d is associated with the differential mobility analyzer (DMA) used to select particle diameters. Calibration is shown to reduce errors of subsequently-measured extinction cross sections of a test aerosol from 11% to <2% with a concomitant improvement in the accuracy of the retrieved complex index of refraction and corresponding atmospheric radiative forcing estimates. C1 [Toole, Justin R.] US Mil Acad, Dept Chem & Life Sci, West Point, NY USA. [Toole, Justin R.; Renbaum-Wolff, Lindsay; Smith, Geoffrey D.] Univ Georgia, Dept Chem, Athens, GA 30602 USA. [Renbaum-Wolff, Lindsay] Univ British Columbia, Dept Chem, Vancouver, BC, Canada. RP Smith, GD (reprint author), Univ Georgia, Dept Chem, 140 Cedar St, Athens, GA 30602 USA. EM gsmith@chem.uga.edu FU National Science Foundation [AGS-0547011] FX The authors gratefully acknowledge support for this research from the National Science Foundation (AGS-0547011). They would also like to thank Professor Ephraim Woods, III of Colgate University for assistance in constructing the cavity ring-down cell, Professor Glenn Smith of the Georgia Institute of Technology for helpful discussions regarding cavity ring-down spectroscopy, and Jeff Baker from TSI, Inc., for loan of a CPC. NR 63 TC 4 Z9 4 U1 1 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD SEP 1 PY 2013 VL 47 IS 9 BP 955 EP 965 DI 10.1080/02786826.2013.805875 PG 11 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 222IZ UT WOS:000324725700002 ER PT J AU Thedinga, JF Johnson, SW Neff, AD Hoffman, CA Maselko, JM AF Thedinga, John F. Johnson, Scott W. Neff, A. Darcie Hoffman, Chris A. Maselko, Jacek M. TI Nearshore Fish Assemblages of the Northeastern Chukchi Sea, Alaska SO ARCTIC LA English DT Article DE Arctic; Alaska; Chukchi Sea; nearshore; Arctic cod; capelin; beach seine; bottom trawl ID COD BOREOGADUS-SAIDA; CAPELIN MALLOTUS-VILLOSUS; BEAUFORT SEA; ARCTIC COD; COASTAL WATERS; BARENTS SEA; COMMUNITY; DEMERSAL; PREDATION AB The Arctic ecosystem is changing rapidly, yet information on nearshore fish assemblages for the northeastern Chukchi Sea is extremely limited. To address this information gap, we sampled nearshore fish assemblages with a beach seine and a small bottom trawl at six stations in the northeastern Chukchi Sea in August 2007, 2008, and 2009, and in September 2009. Catch and species composition differed by gear type and between sample periods, including the two in 2009. A total of 16 039 fish representing 18 species were captured in 24 beach seine hauls, and 3108 fish representing 24 species were captured in 48 trawl tows. Beach seine catch was dominated by capelin (83%), and trawl catch was dominated by Arctic cod (56%). Species that were good discriminators between gear types were capelin (seine) and slender eelblenny (trawl), and unidentified small sculpins were the most common taxa caught with both gear types. Capelin and Arctic cod captured by either gear type were mostly juveniles (judging by size). Variability among sampling periods in catch and species composition within gear types can likely be attributed to annual variations in environmental conditions, including differences in water temperature (range: 2 degrees-9 degrees C). The shallow nearshore environment of the northeastern Chukchi Sea provides important habitat for many fish species and is extremely vulnerable to disturbance. Loss of sea ice from global warming may open up formerly inaccessible areas to oil and gas exploration, vessel traffic, and commercial fishing. Thus, long-term monitoring of nearshore fish assemblages in the Alaskan Arctic is necessary for managers to make informed decisions in this fragile environment. C1 [Thedinga, John F.; Johnson, Scott W.; Neff, A. Darcie; Maselko, Jacek M.] Natl Ocean & Atmospher Adm, Natl Marine Fisheries Serv, Alaska Fisheries Sci Ctr, Juneau, AK 99801 USA. [Hoffman, Chris A.] US Army Corps Engineers, Elmendorf AFB, AK 99506 USA. RP Thedinga, JF (reprint author), Natl Ocean & Atmospher Adm, Natl Marine Fisheries Serv, Alaska Fisheries Sci Ctr, 17109 Point Lena Loop Rd, Juneau, AK 99801 USA. EM jthedinga@gci.net FU NOAA's Essential Fish Habitat Program at the Auke Bay Laboratories of the Alaska Fisheries Science Center FX We especially thank Craig George and the North Slope Borough for providing the invaluable field and logistical support that made this study possible. We also thank Andres Lopez, Estrella Campellone, Dugan Greenwell, John Eiler, Kim Fackler, Mark Carls, and Valerie Palmer for help in the field. We thank Adam Moles for reviewing this manuscript. This project was partially funded by NOAA's Essential Fish Habitat Program at the Auke Bay Laboratories of the Alaska Fisheries Science Center. NR 53 TC 6 Z9 6 U1 0 U2 14 PU ARCTIC INST N AMER PI CALGARY PA UNIV OF CALGARY 2500 UNIVERSITY DRIVE NW 11TH FLOOR LIBRARY TOWER, CALGARY, ALBERTA T2N 1N4, CANADA SN 0004-0843 J9 ARCTIC JI Arctic PD SEP PY 2013 VL 66 IS 3 BP 257 EP 268 PG 12 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA 230AR UT WOS:000325309500002 ER PT J AU Owens, BAM Stahl, MT Corron, NJ Blakely, JN Illing, L AF Owens, Benjamin A. M. Stahl, Mark T. Corron, Ned J. Blakely, Jonathan N. Illing, Lucas TI Exactly solvable chaos in an electromechanical oscillator SO CHAOS LA English DT Article ID BEHAVIOR; EQUATION; DYNAMICS AB A novel electromechanical chaotic oscillator is described that admits an exact analytic solution. The oscillator is a hybrid dynamical system with governing equations that include a linear second order ordinary differential equation with negative damping and a discrete switching condition that controls the oscillatory fixed point. The system produces provably chaotic oscillations with a topological structure similar to either the Lorenz butterfly or Rossler's folded-band oscillator depending on the configuration. Exact solutions are written as a linear convolution of a fixed basis pulse and a sequence of discrete symbols. We find close agreement between the exact analytical solutions and the physical oscillations. Waveform return maps for both configurations show equivalence to either a shift map or tent map, proving the chaotic nature of the oscillations. (C) 2013 AIP Publishing LLC. C1 [Owens, Benjamin A. M.] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA. [Stahl, Mark T.] NASA, George C Marshall Space Flight Ctr, Huntsville, AL 35812 USA. [Corron, Ned J.; Blakely, Jonathan N.] US Army, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. [Illing, Lucas] Reed Coll, Dept Phys, Portland, OR 97202 USA. RP Owens, BAM (reprint author), Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA. EM benjamin.owens@duke.edu OI Corron, Ned/0000-0002-3232-5024 NR 20 TC 7 Z9 7 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1054-1500 J9 CHAOS JI Chaos PD SEP PY 2013 VL 23 IS 3 AR 033109 DI 10.1063/1.4812723 PG 9 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 228AW UT WOS:000325158300009 PM 24089945 ER PT J AU Lott, CA Wiley, RL Fischer, RA Hartfield, PD Scott, JM AF Lott, Casey A. Wiley, Robert L. Fischer, Richard A. Hartfield, Paul D. Scott, J. Michael TI Interior Least Tern (Sternula antillarum) breeding distribution and ecology: implications for population-level studies and the evaluation of alternative management strategies on large, regulated rivers SO ECOLOGY AND EVOLUTION LA English DT Review DE Dispersal; ecological response to dams and flow alteration; large river ecology; metapopulation management; population modeling; sandbar habitat; threatened and endangered species ID LARGE-SCALE CONSERVATION; ENDANGERED-SPECIES-ACT; METAPOPULATION DYNAMICS; REPRODUCTIVE SUCCESS; RIPARIAN VEGETATION; SITE FIDELITY; PLATTE RIVER; GREAT-PLAINS; CALIFORNIA; NEBRASKA AB Interior Least Terns (Sternula antillarum) (ILT) are colonial, fish-eating birds that breed within active channels of large sand bed rivers of the Great Plains and in the Lower Mississippi Valley. Multipurpose dams, irrigation structures, and engineered navigation systems have been present on these rivers for many decades. Despite severe alteration of channels and flow regimes, regulation era floods have remained effective at maintaining bare sandbar nesting habitat on many river segments and ILT populations have been stable or expanding since they were listed as endangered in 1985. We used ILT breeding colony locations from 2002 to 2012 and dispersal information to identify 16 populations and 48 subpopulations. More than 90% of ILT and >83% of river km with suitable nesting habitat occur within the two largest populations. However, replicate populations remain throughout the entire historical, geophysical, and ecological range of ILT. Rapid colonization of anthropogenic habitats in areas that were not historically occupied suggests metapopulation dynamics. The highest likelihood of demographic connectivity among ILT populations occurs across the Southern Plains and the Lower Mississippi River, which may be demographically connected with Least Tern populations on the Gulf Coast. Paired ecological and bird population models are needed to test whether previously articulated threats limit ILT population growth and to determine if management intervention is necessary and where. Given current knowledge, the largest sources of model uncertainty will be: (1) uncertainty in relationships between high flow events and subsequent sandbar characteristics and (2) uncertainty regarding the frequency of dispersal among population subunits. We recommend research strategies to reduce these uncertainties. C1 [Lott, Casey A.] Amer Bird Conservancy, Boise, ID USA. [Wiley, Robert L.] Consulting Ecologist, Athens, OH USA. [Fischer, Richard A.] USACE Engineer Res & Dev Ctr ERDC, Envirnom Lab, Vicksburg, MS USA. [Hartfield, Paul D.] US Fish & Wildlife Serv, Ecol Serv, Jackson, MS USA. [Scott, J. Michael] Univ Idaho, Moscow, ID 83843 USA. RP Lott, CA (reprint author), Amer Bird Conservancy, Boise, ID USA. EM clott@abcbirds.org NR 84 TC 1 Z9 1 U1 5 U2 35 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD SEP PY 2013 VL 3 IS 10 BP 3613 EP 3627 DI 10.1002/ece3.726 PG 15 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA 224ZR UT WOS:000324932600035 PM 24223295 ER PT J AU Perkins, EJ Ankley, GT Crofton, KM Garcia-Reyero, N LaLone, CA Johnson, MS Tietge, JE Villeneuve, DL AF Perkins, Edward J. Ankley, Gerald T. Crofton, Kevin M. Garcia-Reyero, Natalia LaLone, Carlie A. Johnson, Mark S. Tietge, Joseph E. Villeneuve, Daniel L. TI Current Perspectives on the Use of Alternative Species in Human Health and Ecological Hazard Assessments SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID MINNOW PIMEPHALES-PROMELAS; THROUGHPUT SCREENING DATA; AMPHIBIAN METAMORPHOSIS ASSAY; RISK-ASSESSMENT; FATHEAD MINNOW; ENDOCRINE DISRUPTION; THYROID-HORMONE; PERFLUOROOCTANE SULFONATE; END-POINTS; DEVELOPMENTAL TOXICITY AB BACKGROUND: Traditional animal toxicity tests can be time and resource intensive, thereby limiting the number of chemicals that can be comprehensively tested for potential hazards to humans and/or to the environment. OBJECTIVE: We compared several types of data to demonstrate how alternative models can be used to inform both human and ecological risk assessment. METHODS: We reviewed and compared data derived from high throughput in vitro assays to fish reproductive tests for seven chemicals. We investigated whether human-focused assays can be predictive of chemical hazards in the environment. We examined how conserved pathways enable the use of non-mammalian models, such as fathead minnow, zebrafish, and Xenopus laevis, to understand modes of action and to screen for chemical risks to humans. RESULTS: We examined how dose-dependent responses of zebrafish embryos exposed to flusilazole can be extrapolated, using pathway point of departure data and reverse toxicokinetics, to obtain human oral dose hazard values that are similar to published mammalian chronic toxicity values for the chemical. We also examined how development/safety data for human health can be used to help assess potential risks of pharmaceuticals to non-target species in the environment. DISCUSSION: Using several examples, we demonstrate that pathway-based analysis of chemical effects provides new opportunities to use alternative models (non-mammalian species, in vitro tests) to support decision making while reducing animal use and associated costs. CONCLUSIONS: These analyses and examples demonstrate how alternative models can be used to reduce cost and animal use while being protective of both human and ecological health. C1 [Perkins, Edward J.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ankley, Gerald T.; LaLone, Carlie A.; Tietge, Joseph E.; Villeneuve, Daniel L.] US EPA, Off Res & Dev, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. [Crofton, Kevin M.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Johnson, Mark S.] US Army Inst Publ Hlth, Hlth Effects Res Program, Aberdeen Proving Ground, MD USA. RP Perkins, EJ (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM edward.j.perkins@usace.army.mil RI Crofton, Kevin/J-4798-2015 OI Crofton, Kevin/0000-0003-1749-9971 FU U.S. Army Environmental Quality Research Program [BAA 11-4838] FX This work was funded partly by the U.S. Army Environmental Quality Research Program (including BAA 11-4838). NR 108 TC 35 Z9 35 U1 11 U2 92 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD SEP PY 2013 VL 121 IS 9 BP 1002 EP 1010 DI 10.1289/ehp.1306638 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 227XS UT WOS:000325149600013 PM 23771518 ER PT J AU Irvine, KM Thornton, J Backus, VM Hohmann, MG Lehnhoff, EA Maxwell, BD Michels, K Rew, LJ AF Irvine, Kathryn M. Thornton, Jamie Backus, Vickie M. Hohmann, Matthew G. Lehnhoff, Erik A. Maxwell, Bruce D. Michels, Kurt Rew, Lisa J. TI A comparison of adaptive sampling designs and binary spatial models : a simulation study using a census of Bromus inermis SO ENVIRONMETRICS LA English DT Article DE autologistic regression; Bayesian estimation; intrinsic conditionally autoregressive; low prevalence; strip adaptive cluster sampling ID SPECIES DISTRIBUTION; AUTOLOGISTIC REGRESSION; UNDERSTORY PLANTS; HABITAT MODELS; LOCAL-SCALE; ROADS; LANDSCAPE; DISTRIBUTIONS; PREDICTIONS; PERFORMANCE AB Commonly in environmental and ecological studies, species distribution data are recorded as presence or absence throughout a spatial domain of interest. Field based studies typically collect observations by sampling a subset of the spatial domain. We consider the effects of six different adaptive and two non-adaptive sampling designs and choice of three binary models on both predictions to unsampled locations and parameter estimation of the regression coefficients (species-environment relationships). Our simulation study is unique compared to others to date in that we virtually sample a true known spatial distribution of a nonindigenous plant species, Bromus inermis. The census of B. inermis provides a good example of a species distribution that is both sparsely (1.9 % prevalence) and patchily distributed. We find that modeling the spatial correlation using a random effect with an intrinsic Gaussian conditionally autoregressive prior distribution was equivalent or superior to Bayesian autologistic regression in terms of predicting to un-sampled areas when strip adaptive cluster sampling was used to survey B. inermis. However, inferences about the relationships between B. inermis presence and environmental predictors differed between the two spatial binary models. The strip adaptive cluster designs we investigate provided a significant advantage in terms of Markov chain Monte Carlo chain convergence when trying to model a sparsely distributed species across a large area. In general, there was little difference in the choice of neighborhood, although the adaptive king was preferred when transects were randomly placed throughout the spatial domain. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Irvine, Kathryn M.] US Geol Survey, Northern Rocky Mt Sci Ctr, Bozeman, MT USA. [Thornton, Jamie] Thornton Stat Consulting, Seattle, WA USA. [Backus, Vickie M.] Montana State Univ, Bozeman, MT 59717 USA. [Hohmann, Matthew G.] US Army Engineer Res & Dev Ctr, Champaign, IL USA. [Lehnhoff, Erik A.; Maxwell, Bruce D.; Rew, Lisa J.] Montana State Univ, Dept Land Resources & Environm Sci, Bozeman, MT 59717 USA. [Michels, Kurt] Univ Arizona, Dept Math Sci, Tucson, AZ USA. RP Irvine, KM (reprint author), US Geol Survey, Northern Rocky Mt Sci Ctr, Bozeman, MT USA. EM kirvine@usgs.gov FU ERDC CERL [W9132T-09-2-0012] FX We would like to thank Patrick Lawrence and Dan Campbell for helping with field data collection, and Patrick for initial data collation and analysis; both John Long and William Barnett who assisted in the early work on the simulation study and statistical analysis of the inventory data; Cynthia Hollimon for LateX assistance; and Mike Ebinger and Tyler Brummer for improving figure quality. Funding from ERDC CERL grant W9132T-09-2-0012. Little Bighorn Battlefield National Monument for supply of research site and plant distribution data. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the US Government. NR 54 TC 0 Z9 0 U1 4 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1180-4009 J9 ENVIRONMETRICS JI Environmetrics PD SEP PY 2013 VL 24 IS 6 BP 407 EP 417 DI 10.1002/env.2223 PG 11 WC Environmental Sciences; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Environmental Sciences & Ecology; Mathematics GA 225YM UT WOS:000325001200006 ER PT J AU Van Dam, RL Hendrickx, JMH Cassidy, NJ North, RE Dogan, M Borchers, B AF Van Dam, Remke L. Hendrickx, Jan M. H. Cassidy, Nigel J. North, Ryan E. Dogan, Mine Borchers, Brian TI Effects of magnetite on high-frequency ground-penetrating radar SO GEOPHYSICS LA English DT Article ID SOIL-WATER CONTENT; TIME-DOMAIN REFLECTOMETRY; MARS EXPLORATION; IRON MINERALS; MOISTURE; SUSCEPTIBILITY; REFLECTIONS; MIXTURES; SCALE AB Large concentrations of magnetite in sedimentary deposits and soils with igneous parent material have been reported to affect geophysical sensor performance. We have undertaken the first systematic experimental effort to understand the effects of magnetite for ground-penetrating radar (GPR) characterization of the shallow subsurface. Laboratory experiments were conducted to study how homogeneous magnetite-sand mixtures and magnetite concentrated in layers affect the propagation behavior (velocity, attenuation) of high-frequency GPR waves and the reflection characteristics of a buried target. Important observations were that magnetite had a strong effect on signal velocity and reflection, at magnitudes comparable to what has been observed in small-scale laboratory experiments that measured electromagnetic properties of magnetite-silica mixtures. Magnetite also altered signal attenuation and affected the reflection characteristics of buried targets. Our results indicated important implications for several fields, including land mine detection, Martian exploration, engineering, and moisture mapping using satellite remote sensing and radiometers. C1 [Van Dam, Remke L.; Dogan, Mine] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. [Hendrickx, Jan M. H.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, Socorro, NM 87801 USA. [Cassidy, Nigel J.] Keele Univ, Sch Phys & Geog Sci, Keele, Staffs, England. [North, Ryan E.] US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS USA. [Borchers, Brian] New Mexico Inst Min & Technol, Dept Math, Socorro, NM 87801 USA. RP Van Dam, RL (reprint author), Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. EM rvd@msu.edu; hendrick@nmt.edu; n.j.cassidy@esci.keele.ac.uk; ryan.e.north@usace.army.mil; minedoga@msu.edu; borchers@nmt.edu RI Van Dam, Remke/A-2319-2011; Borchers, Brian/C-1984-2008 OI Borchers, Brian/0000-0001-5370-5811 FU United States Army Research Office [STIR19-02-1-027] FX RVD and BB were funded for this research by the United States Army Research Office (STIR19-02-1-027). JH acknowledges support from the United States Army Yuma Proving Ground for sample collection in Panama. RN was granted permission to publish by the director of the Geotechnical & Structures Laboratory. We thank three anonymous reviewers and the associate editor for their suggestions to improve the manuscript. NR 43 TC 5 Z9 5 U1 1 U2 18 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 EI 1942-2156 J9 GEOPHYSICS JI Geophysics PD SEP-OCT PY 2013 VL 78 IS 5 BP H1 EP H11 DI 10.1190/GEO2012-0266.1 PG 11 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 231EA UT WOS:000325395200026 ER PT J AU Kelly, JF McLaughlin, DF Oppenheimer, JH Simmons, JW Cancio, LC Wade, CE Wolf, SE AF Kelly, Joseph F. McLaughlin, Daniel F. Oppenheimer, Jacob H. Simmons, John W., II Cancio, Leopoldo C. Wade, Charles E. Wolf, Steven E. TI A novel means to classify response to resuscitation in the severely burned: Derivation of the KMAC value SO BURNS LA English DT Article DE Burn resuscitation; KMAC; Burn mortality ID MILITARY CASUALTIES; FLUID; FORMULA AB Background: Resuscitation fluid rates following burn are currently guided by a weight and burn size formulae, then titrated to urine output. Traditionally, 24 h resuscitation is reported as volume of resuscitation received without direct consideration for the physiologic response. We propose an input-to-output ratio to describe the course of burn resuscitation and predict eventual outcomes. Methods: We reviewed admissions to a burn center from January 2003 through August 2006. Inclusion criteria were >= 20%TBSA, admission <= 8 h after burn, and survived >= 24 h. Demographics, input volume and urine output, and clinical outcomes were recorded. A ratio of input volume (cc/kg/%TBSA/h) to urine output (cc/kg/h) was calculated at 24 h. The ratio of fluid intake to urine output reflecting an 'expected' response was developed:4 cc/kg/%TBSA/24 h (0.166 cc/kg/%TBSA/h) divided by 0.5-1.0 cc urine/kg/h for an expected range 0.166-0.334. Subjects were classified based upon the ratio: over-responders (<0.166), expected (0.166-0.334), or under-responders (>0.334). Clinical outcomes were compared and concordance of classification to values was calculated at 12 h. Results: 102 subjects met inclusion criteria; 29 in the over-responders, 37 in the expected, and 36 in the under-responders. Resuscitation volume was directly proportional to the calculated ratio while urine output was inversely proportional. Group mortality was 21%, 11%, and 44%, respectively, with a significant difference between the expected and under-responders (p < 0.002). We found decreased ventilator-free days in the under-responders, and when deaths were excluded, decreased ICU-free days as well (p < 0.05). Concordance of paired data gathered at 12 h and 24 h was 67% for the under-responder group. Conclusions: We describe a novel ratio to classify acute resuscitation after severe burn including the patient's response. Such a classification is associated with eventual outcomes. (C) 2013 Elsevier Ltd and ISBI. All rights reserved. C1 [Kelly, Joseph F.; McLaughlin, Daniel F.; Oppenheimer, Jacob H.; Simmons, John W., II; Cancio, Leopoldo C.] US Army Inst Surg Res, San Antonio, TX USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Div Burn Trauma & Crit Care, Dallas, TX 75390 USA. RP Wolf, SE (reprint author), Univ Texas SW Med Ctr Dallas, 5323 Harry Hines, Dallas, TX 75390 USA. EM steven.wolf@utsouthwestern.edu OI Wolf, Steven/0000-0003-2972-3440 NR 15 TC 4 Z9 4 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2013 VL 39 IS 6 BP 1060 EP 1066 DI 10.1016/j.burns.2013.05.016 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 217HE UT WOS:000324349700005 PM 23773791 ER PT J AU Stamm, JF Hendricks, RR Sawyer, JF Mahan, SA Zaprowski, BJ Geibel, NM Azzolini, DC AF Stamm, John F. Hendricks, Robert R. Sawyer, J. Foster Mahan, Shannon A. Zaprowski, Brent J. Geibel, Nicholas M. Azzolini, David C. TI Late Quaternary stream piracy and strath terrace formation along the Belle Fourche and lower Cheyenne Rivers, South Dakota and Wyoming SO GEOMORPHOLOGY LA English DT Article DE Stream piracy; Terraces; Cheyenne; Belle Fourche; Optically stimulated luminescence; Incision rates ID WESTERN UNITED-STATES; NORTH-DAKOTA; ROCKY-MOUNTAINS; MISSOURI RIVER; DOSE-RATES; LUMINESCENCE; CLIMATE; CHRONOLOGY; MONTANA; HISTORY AB Stream piracy substantially affected the geomorphic evolution of the Missouri River watershed and drainages within, including the Little Missouri, Cheyenne, Belle Fourche, Bad, and White Rivers. The ancestral Cheyenne River eroded headward in an annular pattern around the eastern and southern Black Hills and pirated the headwaters of the ancestral Bad and White Rivers after similar to 660 ka. The headwaters of the ancestral Little Missouri River were pirated by the ancestral Belle Fourche River, a tributary to the Cheyenne River that currently drains much of the northern Black Hills. Optically stimulated luminescence (OSL) dating techniques were used to estimate the timing of this piracy event at similar to 22-21 ka. The geomorphic evolution of the Cheyenne and Belle Fourche Rivers is also expressed by regionally recognized strath terraces that include (from oldest to youngest) the Sturgis, Bear Butte, and Farmingdale terraces. Radiocarbon and OSL dates from fluvial deposits on these terraces indicate incision to the level of the Bear Butte terrace by similar to 63 ka, incision to the level of the Farmingdale terrace at similar to 40 ka, and incision to the level of the modern channel after similar to 12-9 ka. Similar dates of terrace incision have been reported for the Laramie and Wind River Ranges. Hypothesized causes of incision are the onset of colder climate during the middle Wisconsinan and the transition to the full-glacial climate of the late-Wisconsinan/Pinedale glaciation. Incision during the Holocene of the lower Cheyenne River is as much as similar to 80 m and is 3 to 4 times the magnitude of incision at similar to 63 ka and similar to 40 ka. The magnitude of incision during the Holocene might be due to a combined effect of three geomorphic processes acting in concert: glacial isostatic rebound in lower reaches (similar to 40 m), a change from glacial to interglacial climate, and adjustments to increased watershed area resulting from piracy of the ancestral headwaters of the Little Missouri River. Published by Elsevier B.V. C1 [Stamm, John F.] US Geol Survey, South Dakota Water Sci Ctr, Rapid City, SD 57702 USA. [Hendricks, Robert R.] McMaster Univ, Sch Geog & Earth Sci, Hamilton, ON L8S 4L8, Canada. [Sawyer, J. Foster] South Dakota Sch Mines & Technol, Dept Geol & Geol Engn, Rapid City, SD 57701 USA. [Mahan, Shannon A.] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. [Zaprowski, Brent J.] Salisbury Univ, Dept Geog & Geosci, Salisbury, MD 21801 USA. [Geibel, Nicholas M.] US Army Corps Engineers, Omaha, NE 68102 USA. [Azzolini, David C.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. RP Stamm, JF (reprint author), US Geol Survey, South Dakota Water Sci Ctr, 1608 Mt View Rd, Rapid City, SD 57702 USA. EM jstamm@usgs.gov OI Mahan, Shannon/0000-0001-5214-7774 NR 59 TC 1 Z9 1 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X EI 1872-695X J9 GEOMORPHOLOGY JI Geomorphology PD SEP 1 PY 2013 VL 197 BP 10 EP 20 DI 10.1016/j.geomorph.2013.03.028 PG 11 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 212NM UT WOS:000323990100002 ER PT J AU L'Amoreaux, P Gibson, S AF L'Amoreaux, Philip Gibson, Stanford TI Quantifying the scale of gravel-bed clusters with spatial statistics SO GEOMORPHOLOGY LA English DT Article DE Clustering; Spatial statistics; Gravel clusters; Gravel orientation ID GRAIN-SIZE; SEDIMENT-TRANSPORT; PARTICLE CLUSTERS; ALLUVIAL CHANNELS; K-FUNCTION; RIVERS; STREAM; MICROFORMS; PATTERNS; SURFACES AB Clustering of large surficial particles affect the critical shear stress, bedload transport rate, and ecological processes of gravel rivers. Particle clusters have been the subject of careful study and taxonomy but would benefit from new quantitative, reproducible, statistical analysis, particularly in the gravel size classes where clusters are difficult to reliably resolve by visual, gestalt methods. This study quantified a clustering length scale for a gravel and cobble bed. The size, orientation, and location of 7726 gravel and cobble particles were measured from 100 photographic samples of a symmetrical bar on the Navarro River, California. Nearest neighbor spatial statistics were used to analyze particle associations. Clustering was identified between gravel particles throughout the river bar. Clustering was also identified for large (>d(84) of the sample) and medium (between the d(50) and d(84) of the sample) particles relative to the local gradation. The spatial scale of these large and medium particle clusters were 1.75d(84) and 3.0d(50), respectively. Published by Elsevier B.V. C1 [L'Amoreaux, Philip; Gibson, Stanford] US Army Corps Engineers, Hydrol Engn Ctr, Davis, CA USA. RP Gibson, S (reprint author), US Army Corps Engineers, Hydrol Engn Ctr, Davis, CA USA. EM stanford.gibson@usace.army.mil NR 44 TC 2 Z9 2 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X J9 GEOMORPHOLOGY JI Geomorphology PD SEP 1 PY 2013 VL 197 BP 56 EP 63 DI 10.1016/j.geomorph.2013.05.002 PG 8 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 212NM UT WOS:000323990100006 ER PT J AU Urso, ML Sawka, MN AF Urso, Maria L. Sawka, Michael N. TI Inflammation: sustaining the balance to optimize recovery of skeletal muscle, connective tissue, and exertional injuries SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Editorial Material C1 [Urso, Maria L.] US Army, Mil Performance Div, Inst Environm Med, Natick, MA USA. [Sawka, Michael N.] Georgia Inst Technol, Sch Appl Physiol, Atlanta, GA 30332 USA. RP Urso, ML (reprint author), Arteriocyte, 45 South St,Suite 3, Hopkinton, MA 01748 USA. EM murso@arteriocyte.com OI Urso, Maria/0000-0001-8906-4673 NR 9 TC 3 Z9 3 U1 0 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 2013 VL 115 IS 6 BP 877 EP 878 DI 10.1152/japplphysiol.00512.2013 PG 2 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 220OT UT WOS:000324594900013 PM 23681912 ER PT J AU Urso, ML AF Urso, Maria L. TI Anti-inflammatory interventions and skeletal muscle injury: benefit or detriment? SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Review DE inflammation; regeneration; eccentric injury; NSAIDs ID DUCHENNE MUSCULAR-DYSTROPHY; TART CHERRY JUICE; RANDOMIZED CONTROLLED-TRIAL; INDUCED OXIDATIVE STRESS; LOCAL NSAID INFUSION; ECCENTRIC EXERCISE; ISCHEMIA-REPERFUSION; RESISTANCE EXERCISE; PROTEIN-SYNTHESIS; CYCLOSPORINE-A AB Exercise, eccentric contractions, acute trauma, and disease are all causal mechanisms of skeletal muscle injury. After skeletal muscle is injured, it undergoes sequential phases of degeneration, inflammation, regeneration, and fibrosis. Events that occur in response to inflammation trigger regenerative processes. However, since inflammation causes pain, decreases skeletal muscle function, has a negative effect on performance, and contributes to fibrosis, which is one of the leading causes of delayed regeneration, the general practice has been to reduce inflammation. The problem with this approach is that preventing inflammation may hinder recovery. Current treatment options for inflammation are not necessarily effective and, in some cases, they may be unsafe. This review focuses on the question of whether the most beneficial course of treatment should be to block inflammation or if it is sensible to allow inflammatory processes to progress naturally. If blocking inflammation is perceived as a beneficial approach, it is not yet known at what time point during the inflammatory response it is most sensible to interfere. To address these issues, this review evaluates the effects of various anti-inflammatory agents on recovery processes in response to exercise-induced, traumatic, and disease-associated models of skeletal muscle injury. A collective analysis such as this should lay the foundation for future work that systematically manipulates the inflammatory response to most effectively promote regeneration and functional recovery in injured skeletal muscle, while reducing the negative effects of inflammatory processes such as pain and fibrosis. C1 [Urso, Maria L.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. RP Urso, ML (reprint author), Arteriocyte, 45 South St,Suite 3, Hopkinton, MA 01748 USA. EM murso@arteriocyte.com OI Urso, Maria/0000-0001-8906-4673 NR 111 TC 25 Z9 26 U1 3 U2 41 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 2013 VL 115 IS 6 BP 920 EP 928 DI 10.1152/japplphysiol.00036.2013 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 220OT UT WOS:000324594900019 PM 23539314 ER PT J AU Ehsanzadeh, E Saley, HM Ouarda, TBMJ Burn, DH Pietroniro, A Seidou, O Charron, C Lee, D AF Ehsanzadeh, E. Saley, H. M. Ouarda, T. B. M. J. Burn, D. H. Pietroniro, A. Seidou, O. Charron, C. Lee, D. TI Analysis of changes in the Great Lakes hydro-climatic variables SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Trend analysis; Shift analysis; Bayesian change point detection; Great Lakes climate; Water levels ID HYDROMETEOROLOGICAL TIME-SERIES; CHANGE-POINT ANALYSIS; MANN-KENDALL TEST; WATER-RESOURCES; SEASONAL CYCLE; TREND ANALYSIS; IMPACT; MODEL; AUTOCORRELATION; APPLICABILITY AB A study of changes in hydro-climatology of the Great Lakes was performed incorporating the nonparametric Mann-Kendall trend detection test and a recently developed Bayesian multiple change point detection model. The Component Net Basin Supply (C-NBS) and its components (runoff, precipitation, evaporation) as well as water levels of Great Lakes were analyzed for gradual (i.e. trend type) and abrupt (i.e. shift type) nonstationary behaviors at seasonal and annual scales. It was found that the C-NBS experienced significant upward trends only in the lower Great Lakes (Erie, Ontario) during the summer portion of the year. At an annual scale upward trends were observed only in Lake Ontario. Change point analysis suggested an upward shift in Great Lakes C-NBS in the late 1960s and early 1970s. A combination of gradual and abrupt change analysis of Great Lakes water levels indicated a common upward shift along with a change in trend direction around the early 1970s. It was also found that precipitation and runoff are on a plateau and in some cases on a decreasing course following an increasing trend in the early twentieth century. Results obtained from this study show that the hydro-climatology of Great Lakes is characterized by nonstationaiy behavior. Changes in this behavior have caused the Great Lakes water levels to decrease during the last few decades. This study provides valuable insights into the nature of the nonstationary behavior of hydro-climatic variables of Great Lakes and contributes useful information to the future water management planning. (C) 2013 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Ehsanzadeh, E.] Ilam Univ, Fac Agr Engn, Ilam, Iran. [Ehsanzadeh, E.; Saley, H. M.; Ouarda, T. B. M. J.; Charron, C.] Univ Quebec, INRS ETE, Canada Res Chair Estimat Hydrol Variables, Hydro Quebec NSERC Chair Stat Hydrol, Quebec City, PQ G1K 9A9, Canada. [Burn, D. H.] Univ Waterloo, Dept Civil & Environm Engn, Waterloo, ON N2L 3G1, Canada. [Pietroniro, A.] Environm Canada, Natl Hydrol Res Ctr, Saskatoon, SK S7N 3H5, Canada. [Seidou, O.] Univ Ottawa, Dept Civil Engn, Ottawa, ON K1N 6N5, Canada. [Lee, D.] US Army Corps Engineers, Water Management Div, Great Lakes & Ohio River Div, Cincinnati, OH 45202 USA. RP Ehsanzadeh, E (reprint author), Ilam Univ, Fac Agr Engn, Pazhouhesh Blvd,POB 69315-516, Ilam, Iran. EM eehsanzadeh@gmail.com; dhbum@civmail.uwaterloo.ca; Al.Pietroniro@ec.gc.ca; oseidou@uottawa.ca; Deborah.H.Lee@usace.army.mil RI Seidou, Ousmane/N-6280-2015; OI Seidou, Ousmane/0000-0003-1706-0176; Charron, Christian/0000-0001-7034-1028 FU International Upper Great Lakes Study (IUGLS); Natural Sciences and Engineering Research Council of Canada (NSERC) FX The financial support provided, by the International Upper Great Lakes Study (IUGLS) and the Natural Sciences and Engineering Research Council of Canada (NSERC) is gratefully acknowledged. The authors would like to thank N. Noorbakhsh and C. Southam co-chairs in data verification Technical Working Group (TWG) for the International Upper Great Lakes Study, and T. Hunter at the Great Lakes Environmental Research Laboratory (GLERL) who were very helpful in organizing and screening the data and also providing helpful comments throughout the study. We would also like to thank P. Pilon, T. Yuzyk, and G. Stakhiv for their support through different stages of this study. NR 65 TC 4 Z9 5 U1 0 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD SEP PY 2013 VL 39 IS 3 BP 383 EP 394 DI 10.1016/j.jglr.2013.06.015 PG 12 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 223WM UT WOS:000324843200002 ER PT J AU Bosch, NS Allan, JD Selegean, JP Scavia, D AF Bosch, Nathan S. Allan, J. David Selegean, James P. Scavia, Donald TI Scenario-testing of agricultural best management practices in Lake Erie watersheds SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE SWAT; Nutrients; Sediments; BMP; Source reduction; Pristine conditions ID ASSESSMENT-TOOL; CONSERVATION PRACTICES; SOUTHEASTERN MICHIGAN; LOADING ANALYSIS; NUTRIENT FLUXES; UNITED-STATES; PHOSPHORUS; SOIL; QUALITY; IMPOUNDMENTS AB Current research has shown that reductions in nonpoint nutrient loading are needed to reduce the incidence of harmful algal blooms and hypoxia in the western and central basins of Lake Erie. We used the Soil and Water Assessment Tool (SWAT) to test various sediment and nutrient load reduction strategies, including agricultural best management practice (BMP) implementation and source reduction in various combinations for six watersheds. These watersheds, in order of decreasing phosphorus loads, include the Maumee, Sandusky, Cuyahoga, Raisin, Grand, and Huron, and together comprise 53% of the binational Lake Erie Basin area. Hypothetical pristine nutrient yields, after eliminating all anthropogenic influences, were estimated to be an order of magnitude lower than current yields, underscoring the need for stronger management actions. However, cover crops, filter strips, and no-till BMPs, when implemented at levels considered feasible, were minimally effective, reducing sediment and nutrient yields by only 0-11% relative to current values. Sediment yield reduction was greater than nutrient yield reduction, and the greatest reduction was found when all three BMPs were implemented simultaneously. When BMPs were targeted at specific locations rather than at random, greater reduction in nutrient yields was achieved with BMPs placed in high source locations, whereas reduction in sediment yields was greatest when BMPs were located near the river outlet. Modest nutrient source reduction also was minimally effective in reducing yields. Our model results indicate that an "all-of-above" strategy is needed to substantially reduce nutrient yields and that BMPs should be much more widely implemented. (C) 2013 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Bosch, Nathan S.] Grace Coll, Winona Lake, IN 46590 USA. [Allan, J. David] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. [Selegean, James P.] US Army Corps Engineers, Great Lakes Hydraul & Hydrol Off, Detroit, MI 48226 USA. [Scavia, Donald] Univ Michigan, Graham Environm Sustainabil Inst, Ann Arbor, MI 48104 USA. RP Bosch, NS (reprint author), Grace Coll, Winona Lake, IN 46590 USA. EM boschns@grace.edu; dallan@umich.edu; james.p.selegean@usace.army.mil; scavia@umich.edu OI Scavia, Donald/0000-0002-2784-8269 FU NOAA Center; United States Army Corps of Engineers FX For their insights into farm management practices and model implementation, we are grateful to Steve Davis, Joe DePinto, Les Ober, Michael Winchell, and Tom VanWagner. This is publication 12-005 of the EcoFore Lake Erie project, funded by the NOAA Center for Sponsored Coastal Ocean Research under award NA070AR4320006. This work was performed under the authority of Section 516(e) of the Water Resources Development Act of 1996 through additional funding by the United States Army Corps of Engineers. NR 42 TC 33 Z9 35 U1 7 U2 105 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD SEP PY 2013 VL 39 IS 3 BP 429 EP 436 DI 10.1016/j.jglr.2013.06.004 PG 8 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 223WM UT WOS:000324843200007 ER PT J AU Neiberg, MS AF Neiberg, Michael S. TI World War I: The American Soldier Experience SO JOURNAL OF SOCIAL HISTORY LA English DT Book Review C1 [Neiberg, Michael S.] US Army, War Coll, Adelphi, MD 20783 USA. RP Neiberg, MS (reprint author), US Army, War Coll, Adelphi, MD 20783 USA. EM neiberg102@gmail.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-4529 J9 J SOC HIST JI J. Soc. Hist. PD FAL PY 2013 VL 47 IS 1 BP 227 EP 228 DI 10.1093/jsh/sht018 PG 2 WC History SC History GA 217OM UT WOS:000324368800013 ER PT J AU Koehler, JW Smith, JM Ripoll, DR Spik, KW Taylor, SL Badger, CV Grant, RJ Ogg, MM Wallqvist, A Guttieri, MC Garry, RF Schmaljohn, CS AF Koehler, Jeffrey W. Smith, Jeffrey M. Ripoll, Daniel R. Spik, Kristin W. Taylor, Shannon L. Badger, Catherine V. Grant, Rebecca J. Ogg, Monica M. Wallqvist, Anders Guttieri, Mary C. Garry, Robert F. Schmaljohn, Connie S. TI A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID BORNE ENCEPHALITIS-VIRUS; SEMLIKI-FOREST-VIRUS; CELL-CELL FUSION; MEMBRANE-FUSION; ENVELOPE GLYCOPROTEIN; DENGUE VIRUS; CRYSTAL-STRUCTURE; EBOLA-VIRUS; WORLD HANTAVIRUSES; SAUDI-ARABIA AB For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein sequence and structure. For Rift Valley fever virus (RVFV), the glycoprotein Gc (Class II fusion protein) mediates this fusion event following entry into the endocytic pathway, allowing the viral genome access to the cell cytoplasm. Here, we show that peptides analogous to the RVFV Gc stem region inhibited RVFV infectivity in cell culture by inhibiting the fusion process. Further, we show that infectivity can be inhibited for diverse, unrelated RNA viruses that have Class I (Ebola virus), Class II (Andes virus), or Class III (vesicular stomatitis virus) fusion proteins using this single peptide. Our findings are consistent with an inhibition mechanism similar to that proposed for stem peptide fusion inhibitors of dengue virus in which the RVFV inhibitory peptide first binds to both the virion and cell membranes, allowing it to traffic with the virus into the endocytic pathway. Upon acidification and rearrangement of Gc, the peptide is then able to specifically bind to Gc and prevent fusion of the viral and endocytic membranes, thus inhibiting viral infection. These results could provide novel insights into conserved features among the three classes of viral fusion proteins and offer direction for the future development of broadly active fusion inhibitors. C1 [Koehler, Jeffrey W.; Smith, Jeffrey M.; Spik, Kristin W.; Taylor, Shannon L.; Badger, Catherine V.; Grant, Rebecca J.; Ogg, Monica M.; Guttieri, Mary C.; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD USA. [Ripoll, Daniel R.; Wallqvist, Anders] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Garry, Robert F.] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA. RP Koehler, JW (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD USA. EM connie.schmaljohn@amedd.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency (DTRA) [4.10062_09_RD_B]; United States Department of Defense (DoD) High-Performance Computing Modernization Program FX Support for this research was provided by the Defense Threat Reduction Agency (DTRA, http://www.dtra.mil/) under project number 4.10062_09_RD_B and the United States Department of Defense (DoD) High-Performance Computing Modernization Program (http://www.hpcmo.hpc.mil/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 6 Z9 6 U1 0 U2 19 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2013 VL 7 IS 9 AR e2430 DI 10.1371/journal.pntd.0002430 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 224WA UT WOS:000324920800035 PM 24069485 ER PT J AU Zapata, JC Carrion, R Patterson, JL Crasta, O Zhang, Y Mani, S Jett, M Poonia, B Djavani, M White, DM Lukashevich, IS Salvato, MS AF Zapata, Juan Carlos Carrion, Ricardo, Jr. Patterson, Jean L. Crasta, Oswald Zhang, Yan Mani, Sachin Jett, Marti Poonia, Bhawna Djavani, Mahmoud White, David M. Lukashevich, Igor S. Salvato, Maria S. TI Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEPARIN-BINDING EGF; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ARENAVIRUS HEMORRHAGIC FEVERS; HUMAN DENDRITIC CELLS; NF-KAPPA-B; GENE-EXPRESSION; GROWTH-FACTOR; RHESUS MACAQUES; CHEMOTACTIC PROTEIN-2; HUMAN CYTOMEGALOVIRUS AB Lassa virus (LASV) is the causative agent of Lassa Fever and is responsible for several hundred thousand infections and thousands of deaths annually in West Africa. LASV and the non-pathogenic Mopeia virus (MOPV) are both rodent-borne African arenaviruses. A live attenuated reassortant of MOPV and LASV, designated ML29, protects rodents and primates from LASV challenge and appears to be more attenuated than MOPV. To gain better insight into LASV-induced pathology and mechanism of attenuation we performed gene expression profiling in human peripheral blood mononuclear cells (PBMC) exposed to LASV and the vaccine candidate ML29. PBMC from healthy human subjects were exposed to either LASV or ML29. Although most PBMC are non-permissive for virus replication, they remain susceptible to signal transduction by virus particles. Total RNA was extracted and global gene expression was evaluated during the first 24 hours using high-density microarrays. Results were validated using RT-PCR, flow cytometry and ELISA. LASV and ML29 elicited differential expression of interferon-stimulated genes (ISG), as well as genes involved in apoptosis, NF-kB signaling and the coagulation pathways. These genes could eventually serve as biomarkers to predict disease outcomes. The remarkable differential expression of thrombomodulin, a key regulator of inflammation and coagulation, suggests its involvement with vascular abnormalities and mortality in Lassa fever disease. C1 [Zapata, Juan Carlos; Poonia, Bhawna; Djavani, Mahmoud; Lukashevich, Igor S.; Salvato, Maria S.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Carrion, Ricardo, Jr.; Patterson, Jean L.] Texas Biomed Res Inst, San Antonio, TX USA. [Crasta, Oswald; Zhang, Yan] Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA USA. [Mani, Sachin; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [White, David M.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Zapata, JC (reprint author), Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. EM jczapata@ihv.umaryland.edu FU National Institutes of Health; Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases Research, MARCE [U54 AI057168]; WRCE [U54 AI057156]; NIH [AI053620, AI053619]; US-CDC FX This work was supported by funding from the National Institutes of Health and by the Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases Research, MARCE (U54 AI057168, subcontracts to MSS and to ISL) and WRCE (U54 AI057156, subcontract to JLP and RC). Funding for microarray studies was from NIH grants AI053620 and AI053619 (to MSS). DC infections with LASV and ELISA conducted at the USCDC BSL-4 facilities by DMW were supported by the US-CDC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 99 TC 8 Z9 8 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2013 VL 7 IS 9 AR e2406 DI 10.1371/journal.pntd.0002406 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 224WA UT WOS:000324920800015 PM 24069471 ER PT J AU MacDonald, HZ Proctor, SP Heeren, T Vasterling, JJ AF MacDonald, Helen Z. Proctor, Susan P. Heeren, Timothy Vasterling, Jennifer J. TI Associations of Postdeployment PTSD Symptoms With Predeployment Symptoms in Iraq-Deployed Army Soldiers SO PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY LA English DT Article DE PTSD symptom clusters; OIF; deployment; longitudinal ID POSTTRAUMATIC-STRESS-DISORDER; CONFIRMATORY FACTOR-ANALYSIS; GULF-WAR VETERANS; PSYCHOLOGICAL DISTRESS; LONGITUDINAL COURSE; MENTAL-HEALTH; TRAUMA; COMORBIDITY; MILITARY; SAMPLE AB Prior to deployment, military personnel may experience a range of symptoms typically associated with posttraumatic stress disorder (PTSD); however, the relationship of specific preexisting symptoms characteristic of PTSD to postdeployment PTSD symptoms is not well understood. This prospective study examined (a) pre- to postdeployment changes in reexperiencing, avoidance, numbing, and hyperarousal symptoms among Iraq-deployed military personnel, and (b) pre- to postdeployment associations among these symptom groupings. Seven-hundred and seventy-four U.S. Army soldiers completed the PTSD Checklist pre- and postdeployment to Iraq. Participants demonstrated increases in reexperiencing, avoidance, and hyperarousal symptom severity but not in severity of numbing symptoms from pre- to postdeployment. Predeployment numbing was positively correlated with all postdeployment symptom clusters, and predeployment hyperarousal was positively correlated with postdeployment hyperarousal, reexperiencing, and numbing. Findings highlight the role of preexisting numbing and hyperarousal symptoms in the evolution of PTSD symptoms following trauma exposure. C1 [MacDonald, Helen Z.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [MacDonald, Helen Z.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, VA Natl Ctr PTSD, Boston, MA 02130 USA. [MacDonald, Helen Z.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [MacDonald, Helen Z.; Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA 02130 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA. [Heeren, Timothy] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. RP MacDonald, HZ (reprint author), VA Boston Healthcare Syst, 150 S Huntington Ave 116B-4, Boston, MA 02130 USA. EM hzm@bu.edu NR 40 TC 5 Z9 5 U1 7 U2 18 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1942-9681 J9 PSYCHOL TRAUMA-US JI Psychol. Trauma PD SEP PY 2013 VL 5 IS 5 BP 470 EP 476 DI 10.1037/a0029010 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 219NY UT WOS:000324514900010 ER PT J AU Mansoor, GF Rahmani, AM Kakar, MA Hashimy, P Abrahimi, P Scott, PT Peel, SA Rentas, FJ Todd, CS AF Mansoor, G. Farooq Rahmani, Ahmad Masoud Kakar, M. Aziz Hashimy, Pashtoon Abrahimi, Parwiz Scott, Paul T. Peel, Sheila A. Rentas, Francisco J. Todd, Catherine S. TI Blood supply safety in Afghanistan: a national assessment of high-volume facilities SO TRANSFUSION LA English DT Article ID SUB-SAHARAN AFRICA; HUMAN-IMMUNODEFICIENCY-VIRUS; HEALTH FACILITIES; PATIENT SAFETY; TRANSFUSION; RISK; INFECTIONS; DONATION; DONORS; CARE AB Background Little information is available regarding blood supply safety in Afghanistan. The purpose of this study was to assess blood safety through serologic and observational measures in Afghanistan. Study Design and Methods This cross-sectional assessment included the 40 highest-volume facilities collecting and transfusing blood nationally identified in a previous survey. At each facility, study representatives completed a standardized instrument assessing staff performance of transfusion-related activities and performed rapid testing for human immunodeficiency virus, syphilis, and hepatitis B and C with rapid diagnostic tests on clinically discarded specimens. Reactive samples received confirmatory testing. Descriptive statistics were generated, with differences analyzed using chi-square or Fisher's exact tests. Results Between November 2010 and May 2011, a total of 332 blood donor collection procedures were observed. Only 52.4% of observed encounters correctly screened and deferred donors by international criteria. Public and private facilities demonstrated glove use, proper sharps disposal, and patient counseling and relayed screening test results in less than 75% of observed events, significantly less likely than military facilities (p<0.01). Of 1612 specimens assessed, confirmed cases of hepatitis B (n=6), hepatitis C (n=1), and syphilis (n=3) were detected among units already prescreened and accepted for transfusion. Conclusion Lapses in proper donor screening contributed to the presence of confirmed-positive units available for transfusion, as detected in this study. Steps must be taken to ensure standardization of testing kits requirements, documentation, and mandatory training and continuing education for blood bank staff with regard to counseling, drawing, processing, and transfusion of blood products. C1 Yale Univ, Sch Med, New Haven, CT USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. US Dept Def, Armed Serv Blood Program Off, Washington, DC 20305 USA. [Todd, Catherine S.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10032 USA. RP Todd, CS (reprint author), Columbia Univ, Dept Obstet & Gynecol, PH 16-69,622 West 168th St, New York, NY 10032 USA. EM cst2121@columbia.edu FU NIH MSTP TG [T32GM07205] FX We thank the Afghan National Blood Safety and Transfusion Services and the Afghan Public Health Institute of the Ministry of Public Health for their assistance with project coordination and our survey staff for their diligent work. We acknowledge LTC Ron Gagliano, MD, whose service in Afghanistan identified the need for this study. PA appreciates support from NIH MSTP TG T32GM07205. NR 45 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2013 VL 53 IS 9 BP 2061 EP 2068 DI 10.1111/trf.12005 PG 8 WC Hematology SC Hematology GA 213KG UT WOS:000324055200027 PM 23216410 ER PT J AU Vanderwerf, EA Lohr, MT Titmus, AJ Taylor, PE Burt, MD AF Vanderwerf, Eric A. Lohr, Michael T. Titmus, Andrew J. Taylor, Philip E. Burt, Matthew D. TI CURRENT DISTRIBUTION AND ABUNDANCE OF THE O'AHU 'ELEPAIO (CHASIEMPIS IBIDIS) SO WILSON JOURNAL OF ORNITHOLOGY LA English DT Article DE abundance; detection probability; Hawai'i; O'ahu 'Elepaio; range ID HAWAII ELEPAIO; CONSERVATION; PREDATION; HABITAT; BIRDS AB The O'ahu 'Elepaio (Chasiempis ibidis) is an endangered monarch flycatcher endemic to the Hawaiian Island of O'ahu. Current information on abundance, distribution, and population trend is needed to help assess the species status and identify areas where conservation efforts can be focused. We used spot-mapping methods with song playbacks to conduct surveys in the Ko'olau Mountains from 2011-2012, and we used occupancy sampling with repeated visits to estimate detection probability. We detected 545 male and 317 female O'ahu 'Elepaio. The detection probability of males was 0.92 +/- 0.03 and that of females was 0.86 +/- 0.05, yielding corrected estimates of 592 males (95% CI = 554-630) and 369 females (95% CI = 327-411), Combined with results of a previous census in the Wai'anae Mountains that found 192 males and 84 females, the total estimated population of the species is 1,261 birds (95% CI = 1,205-1,317), consisting of about 477 breeding pairs and 307 single males. The O'ahu 'Elepaio has declined in abundance by about 50% since the 1990s, when the population was estimated to be about 1,974 birds. The current geographic range of the O'ahu 'Elepaio encompassed about 5,187 ha and has declined by 75% since 1975, becoming fragmented into four larger subpopulations with 100 or more birds each and 12 smaller subpopulations. Rat control to reduce nest predation remains the cornerstone of the conservation strategy for the O'ahu 'Elepaio, but variation in forest structure, forest dynamics, and continuing evolution of 'elepaio nesting behavior are likely to play important roles in determining whether this species can persist. C1 [Vanderwerf, Eric A.; Lohr, Michael T.; Titmus, Andrew J.] Pacific Rim Conservat, Honolulu, HI 96822 USA. [Taylor, Philip E.; Burt, Matthew D.] US Army Garrison, Environm Div, Directorate Publ Works, Schofield Barracks, HI 96857 USA. RP Vanderwerf, EA (reprint author), Pacific Rim Conservat, 3038 Oahu Ave, Honolulu, HI 96822 USA. EM eric@pacificrimconservation.com FU U.S. Fish and Wildlife Service; U.S. Army FX Funding for O'ahu 'Elepaio surveys in the Ko'olau Mountains was provided by the U.S. Fish and Wildlife Service. Monitoring of O'ahu 'Elepaio in Moanalua Valley was funded by the U.S. Army. For granting access to conduct surveys, we thank the Hawai'i Division of Forestry and Wildlife, the Hawaii Division of State Parks, the U.S. Fish and Wildlife Service, the U.S. Army, the Honolulu Board of Water Supply, Ohulehule Forest Conservancy, Laura Thompson, and the Oahu Country Club. For assistance with surveys we thank Amy Tsuneyoshi and Paul Zweng. The manuscript was improved by comments from Rick Camp and an anonymous reviewer. NR 36 TC 1 Z9 1 U1 2 U2 13 PU WILSON ORNITHOLOGICAL SOC PI WACO PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710 USA SN 1559-4491 J9 WILSON J ORNITHOL JI Wilson J. Ornithol. PD SEP PY 2013 VL 125 IS 3 BP 600 EP 608 PG 9 WC Ornithology SC Zoology GA 222GH UT WOS:000324718700016 ER PT J AU Kirkup, BC Mahlen, S Kallstrom, G AF Kirkup, Benjamin C. Mahlen, Steven Kallstrom, George TI Future-Generation Sequencing and Clinical Microbiology SO CLINICS IN LABORATORY MEDICINE LA English DT Article DE Sequencing; Clinical microbiology; Genomics ID RIBOSOMAL-RNA GENE; SINGLE POLYMERASE MOLECULES; ESCHERICHIA-COLI; BACTERIAL COMMUNITIES; NUCLEOTIDE-SEQUENCES; INCIDENTAL FINDINGS; BRAIN ABSCESSES; MIC BREAKPOINTS; CHRONIC WOUNDS; GENOME AB Sequencing technologies are changing the way both laboratory medicine and clinical practice impact patient care. This article focuses on the clinical microbiology laboratory and the potential benefits and limitations of coming generations of sequencing technology. Nucleic acid sequencing technology is rapidly outpacing the infrastructure needed to accurately educate, analyze, and interpret complex massive data sets that are rapidly becoming integrated into clinical practice. C1 [Kirkup, Benjamin C.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA. [Mahlen, Steven] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Kallstrom, George] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Kallstrom, G (reprint author), Tripler Army Med Ctr, Dept Pathol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM george.kallstrom@us.army.mil RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 NR 157 TC 0 Z9 0 U1 0 U2 26 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-2712 J9 CLIN LAB MED JI Clin. Lab. Med. PD SEP PY 2013 VL 33 IS 3 BP 685 EP + DI 10.1016/j.cll.2013.03.011 PG 21 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 215PB UT WOS:000324221600013 PM 23931844 ER PT J AU McKay, SK Schramski, JR Conyngham, JN Fischenich, JC AF McKay, S. Kyle Schramski, John R. Conyngham, Jock N. Fischenich, J. Craig TI Assessing upstream fish passage connectivity with network analysis SO ECOLOGICAL APPLICATIONS LA English DT Article DE cumulative effects; dam removal; fish passage; graph theory; habitat connectivity index for upstream passage; Truckee River; Nevada; USA ID HYDROLOGIC CONNECTIVITY; RIVER RESTORATION; DAM REMOVAL; LANDSCAPE CONNECTIVITY; AMPHIBIAN PERSISTENCE; TROPICAL STREAMS; PUERTO-RICO; BARRIERS; WATER; PERSPECTIVE AB Hydrologic connectivity is critical to the structure, function, and dynamic process of river ecosystems. Dams, road crossings, and water diversions impact connectivity by altering flow regimes, behavioral cues, local geomorphology, and nutrient cycling. This longitudinal fragmentation of river ecosystems also increases genetic and reproductive isolation of aquatic biota such as migratory fishes. The cumulative effects on fish passage of many structures along a river are often substantial, even when individual barriers have negligible impact. Habitat connectivity can be improved through dam removal or other means of fish passage improvement (e.g., ladders, bypasses, culvert improvement). Environmental managers require techniques for comparing alternative fish passage restoration actions at alternative or multiple locations. Herein, we examined a graph-theoretic algorithm for assessing upstream habitat connectivity to investigate both basic and applied fish passage connectivity problems. First, we used hypothetical watershed configurations to assess general alterations to upstream fish passage connectivity with changes in watershed network topology (e.g., linear vs. highly dendritic) and the quantity, location, and passability of each barrier. Our hypothetical network modeling indicates that locations of dams with limited passage efficiency near the watershed outlet create a strong fragmentation signal but are not individually sufficient to disconnect the system. Furthermore, there exists a threshold in the number of dams beyond which connectivity declines precipitously, regardless of watershed topology and dam configuration. Watersheds with highly branched configurations are shown to be less susceptible to disconnection as measured by this metric. Second, we applied the model to prioritize barrier improvement in the mainstem of the Truckee River, Nevada, USA. The Truckee River application demonstrates the ability of the algorithm to address conditions common in fish passage projects including incomplete data, parameter uncertainty, and rapid application. This study demonstrates the utility of a graph-theoretic approach for assessing fish passage connectivity in dendritic river networks assuming full basin utilization for a given species, guild, or community of concern. C1 [McKay, S. Kyle] US Army Engineer Res & Dev Ctr, Environm Lab, Athens, GA 30606 USA. [Schramski, John R.] Univ Georgia, Coll Engn, Athens, GA 30602 USA. [Conyngham, Jock N.] US Army Engineer Res & Dev Ctr, Environm Lab, Missoula, MT 59801 USA. [Fischenich, J. Craig] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP McKay, SK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Athens, GA 30606 USA. EM kyle.mckay@usace.army.mil FU U.S. Army Corps of Engineers FX The U.S. Army Corps of Engineers funded this research through the Ecosystem Management and Restoration Research Program (http://www.el.erdc.usace.army.mil/emrrp/), the long-term training program, and the Sacramento District Truckee Meadows Flood Control Project. The original Truckee River application (Conyngham et al. 2011) was both vetted by and parameterized by the professional judgments of Craig Fischenich, Lisa Heki, Jay Kidder, Matt Maples, David Potter, Gary Scoppettone, and Kim Tisdale. This paper presents a significantly simplified version of Truckee River analyses with the original project incorporating significantly greater complexity (e. g., eight fish species, objectives associated with species status). As such, the results presented here are merely a demonstration of the HCIU and do not represent outcomes of the Corps' project planning process. Additional project details and status may be obtained from the Sacramento District of the U.S. Army Corps of Engineers (http://www.spk.usace.army.mil/). Dan Artho, Leigh Skaggs, and Matthew Deason provided model development guidance. Duncan Elkins, Todd Swannack, Larry Oliver, Joe Moran, Bill Fagan, and an anonymous referee reviewed and significantly improved an early draft of this document. S. K. McKay led study design, numerical model construction, interpretation of results, and manuscript preparation. J. R. Schramski contributed to study design, development of the graph-theoretic algorithm, interpretation of results, and manuscript preparation. J. Conyngham and J. C. Fischenich provided the original idea for the study, collected Truckee River data, and assisted in manuscript preparation and revision. NR 83 TC 18 Z9 20 U1 14 U2 147 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1051-0761 J9 ECOL APPL JI Ecol. Appl. PD SEP PY 2013 VL 23 IS 6 BP 1396 EP 1409 DI 10.1890/12-1564.1 PG 14 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 211UD UT WOS:000323935700014 PM 24147411 ER PT J AU Breitzer, SR AF Breitzer, Susan Roth TI A Perfect Fit: The Garment Industry and American Jewry, 1860-1960. SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Breitzer, Susan Roth] Campbell Univ, Ft Bragg, NC USA. RP Breitzer, SR (reprint author), Campbell Univ, Ft Bragg, NC USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 2013 VL 100 IS 2 BP 543 EP 543 DI 10.1093/jahist/jat203 PG 1 WC History SC History GA 205EI UT WOS:000323424600077 ER PT J AU Albrecht, M Kneeland, KM Lindroth, E Foster, JE AF Albrecht, M. Kneeland, K. M. Lindroth, E. Foster, J. E. TI Genetic diversity and relatedness of the mangrove Rhizophora mangle L. (Rhizophoraceae) using amplified fragment polymorphism (AFLP) among locations in Florida, USA and the Caribbean SO JOURNAL OF COASTAL CONSERVATION LA English DT Article DE Mangrove; AFLP; Florida; Caribbean ID MOLECULAR MARKERS; POPULATIONS; EVOLUTION; FORESTS; VARIABILITY; PATTERNS AB Rhizophora mangle L. is a widespread mangrove species in the Western Hemisphere. Mangrove habitat loss and their importance to coastal and reef ecosystems make greater understanding of their genetic structure useful for conservation and management. An amplified fragment polymorphism (AFLP) analysis was performed on samples from Florida and the Caribbean to discover the genetic structure present. R. mangle had variable genetic diversity not related to latitude; P ranged 7 %-92 %. Some other factor, perhaps human impact, has caused low genetic diversity in some populations. Across Florida R. mangle populations varied in genetic diversity with less diversity (G(st) = 0.195) and greater gene flow on the Atlantic coast (Nm =2.07) than on the Gulf coast (G(st) = 0.717, Nm = 0.197). Gene flow between Caribbean islands was low (Nm = 0.386) compared to continental populations (Nm = 1.40), indicating that long distance dispersal is not common between islands. Analysis of molecular variance (AMOVA) analysis showed significant deviations from Hardy-Weinberg expectations at the level of region among subpopulations and overall genetic difference among subpopulations for R. mangle. One implication for management is that small continental populations and island populations may be genetically isolated and distinct from each other. C1 [Albrecht, M.] Univ Nebraska Kearney, Dept Biol, Kearney, NE 68849 USA. [Kneeland, K. M.; Foster, J. E.] Univ Nebraska, Dept Entomol, Lincoln, NE 68583 USA. [Lindroth, E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Albrecht, M (reprint author), Univ Nebraska Kearney, Dept Biol, Bruner Hall 323,2401 11th St, Kearney, NE 68849 USA. EM albrechtm@unk.edu NR 51 TC 2 Z9 3 U1 2 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1400-0350 EI 1874-7841 J9 J COAST CONSERV JI J. Coast. Conserv. PD SEP PY 2013 VL 17 IS 3 BP 483 EP 491 DI 10.1007/s11852-013-0246-3 PG 9 WC Biodiversity Conservation; Environmental Sciences; Marine & Freshwater Biology; Water Resources SC Biodiversity & Conservation; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 214DE UT WOS:000324110200016 ER PT J AU Hamilton, MC Lambert, JH Keisler, JM Holcomb, FH Linkov, I AF Hamilton, Michelle C. Lambert, James H. Keisler, Jeffrey M. Holcomb, Franklin H. Linkov, Igor TI Research and Development Priorities for Energy Islanding of Military and Industrial Installations SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Energy; Risk management; Investments; Infrastructure; Uncertainty principles; Installation; Energy; Multiple objective analysis; Risk management; Technology assessment; Sustainable development ID DEVELOPMENT PROJECT-SELECTION; INVESTMENTS; EMERGENT; POWER AB Research and development for energy systems (e.g.,smart and secure microgrids for industrial and military installations and solar cogeneration technologies) must account for deep uncertainties and emergent conditions including economic, regulatory, technological, mission, demographic, and environmental or ecological, among others. Deep uncertainties involve structural and qualitative perspectives or trends that change the game. Recent literature has identified emergent conditions and deep uncertainties that are most influential to decision criteria priorities among existing energy assets and systems. This paper introduces a practical method to help prioritize strategic energy research and development investments and minimize opportunity loss or program risk for investments with a long time horizon. There are a number of interesting observations that can be perceived from this method including robustness, scenario influence, risk, and opportunity. The method is recommended to help achieve consensus of program managers, installation commanders, energy managers, technology vendors, urban planners, and customers and tenants. A quantitative demonstration is provided that addresses five scenarios of deep uncertainty, ten performance criteria, and six investment portfolios. (C) 2013 American Society of Civil Engineers. C1 [Hamilton, Michelle C.; Lambert, James H.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22903 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Dept Management Informat Syst, Boston, MA 02125 USA. [Holcomb, Franklin H.] US Army Corps Engineers, Ctr Res & Dev, Champaign, IL 61822 USA. [Linkov, Igor] US Army Corps Engineers, Ctr Res & Dev, Concord, MA 01742 USA. RP Lambert, JH (reprint author), Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22903 USA. EM lambert@virginia.edu FU American Recovery and Reinvestment Act through ERDC/USACE [W9132T-10-C-0019] FX The following individuals contributed to the effort: Tarek Abdallah [Engineer Research Development Center (ERDC)/Construction Engineering Research Laboratory (CERL)/United States Army Corps of Engineers (USACE)], Melanie Johnson (ERDC/CERL), Chris W. Karvetski, Ph.D. (George Mason University), Renae D. Ditmer, Ph.D. (STRATCON LLC), Kevin Brady [Lead, Ft. Belvoir Night Vision and Electronic Sensors Directorate (NVESD) Energy Working Group], Bill Elliott (Ft. Belvoir NVESD Energy Working Group), and Randy Roy (Lars Energy and Ft. Belvoir NVESD Energy Working Group). This effort is supported by the American Recovery and Reinvestment Act through ERDC/USACE contract W9132T-10-C-0019. Permission was granted by the Chief of Engineers to publish this information. The views and opinions expressed in this paper are those of the individual authors and not those of the U. S. Army or other sponsor agencies. NR 31 TC 5 Z9 5 U1 2 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD SEP 1 PY 2013 VL 19 IS 3 BP 297 EP 305 DI 10.1061/(ASCE)IS.1943-555X.0000133 PG 9 WC Engineering, Civil SC Engineering GA 198XZ UT WOS:000322958600006 ER PT J AU Turell, MJ Britch, SC Aldridge, RL Kline, DL Boohene, C Linthicum, KJ AF Turell, Michael J. Britch, Seth C. Aldridge, Robert L. Kline, Daniel L. Boohene, Carl Linthicum, Kenneth J. TI Potential for Mosquitoes (Diptera: Culicidae) From Florida to Transmit Rift Valley Fever Virus SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE competence; vector; transmission; North America ID HOST-FEEDING PATTERNS; CONTINENTAL UNITED-STATES; NORTH-AMERICAN MOSQUITOS; SAUDI-ARABIA; CULEX-PIPIENS; ENVIRONMENTAL-TEMPERATURE; PHLEBOTOMUS-DUBOSCQI; AEDES-TAENIORHYNCHUS; VECTOR COMPETENCE; BRUGIA-MALAYI AB We evaluated Aedes atlanticus Dyar and Knab, Aedes infirmatus Dyar and Knab, Aedes vexans (Meigen), Anopheles crucians Wiedemann, Coquillettidia perturbans (Walker), Culex nigripalpus Theobald, Mansonia dyari Belkin, Heinemann, and Page, and Psorophora ferox (Von Humboldt) from Florida to determine which of these species should be targeted for control should Rift Valley fever virus (RVFV) be detected in North America. Female mosquitoes that had fed on adult hamsters inoculated with RVFV were incubated for 7D21 d at 26 degrees C, then allowed to refeed on susceptible hamsters, and tested to determine infection, dissemination, and transmission rates. We also inoculated mosquitoes intrathoracically, held them for 7 d, and then allowed them to feed on a susceptible hamster to check for a salivary gland barrier. When exposed to hamsters with viremias >= 10(7.6) plaque-forming units per milliliter of blood, at least some individuals in each of the species tested became infected; however, Cx. nigripalpus, An. crucians, and Ae. infirmatus were essentially incompetent vectors in the laboratory because of either a midgut escape or salivary gland barrier. Each of the other species should be considered as potential vectors and would need to be controlled if RVFV were introduced into an area where they were found. Additional studies need to be conducted with other geographic populations of these species and to determine how environmental factors affect transmission. C1 [Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Britch, Seth C.; Aldridge, Robert L.; Kline, Daniel L.; Linthicum, Kenneth J.] USDA ARS, Ctr Med Agr & Vet Entomol, Mosquito & Fly Res Unit, Gainesville, FL 32608 USA. Polk Cty Mosquito Control, Bartow, FL 33830 USA. RP Turell, MJ (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.j.turell@us.army.mil FU U.S. Department of Homeland Security Science and Technology Directorate [HSHQDC-11-X-00326] FX We thank M. Mahler and N. Harboe (Polk County Parks & Natural Resources Division) for assistance in trapping mosquitoes; S. Padilla, D. Dohm, and S. Pisarcik (USAMRIID) for processing and testing mosquito specimens; J. Williams (USAMRIID) for caring for the hamsters; and K. Kenyon (USAMRIID) for her editorial suggestions. This work was supported by a grant HSHQDC-11-X-00326 from the U.S. Department of Homeland Security Science and Technology Directorate. NR 50 TC 11 Z9 11 U1 0 U2 17 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2013 VL 50 IS 5 BP 1111 EP 1117 DI 10.1603/ME13049 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 217QI UT WOS:000324374100022 PM 24180117 ER PT J AU Huang, YM Rueda, LM AF Huang, Yiau-Min Rueda, Leopoldo M. TI A NEW SPECIES OF THE GENUS ORTHOPODOMYIA FROM OTOTOMO, CAMEROON, WITH NOTES ON OTHER ORTHOPODOMYIA GROUP-SPECIES SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Orthopodomyia ototomoensis; Ototomoensis Group; Nkolbissonensis Group; morphology; Cameroon AB A new species belonging to the new Ototomoensis Group, Orthopodomyia ototomoensis Huang and Rueda, is described from Ototomo, Cameroon. Diagnostic features for separating members of Nkolbissonensis Group and Ototomoensis Group from other Orthopodomyia groups are provided. Two supplemental keys are presented: "A Pictorial Key to the Species of the Genus Orthopodomyia Ototomoensis Group in the Afrotropical Region (Diptera: Culicidae)" and "A Pictorial Key to the Species of the Genus Orthopodomyia Nkolbissonensis Group in the Afrotropical Region (Diptera: Culicidae).'' C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2013 VL 29 IS 3 BP 270 EP 274 PG 5 WC Entomology SC Entomology GA 217SJ UT WOS:000324380600007 PM 24199501 ER PT J AU Gubata, ME Packnett, ER Feng, XS Cowan, DN Niebuhr, DW AF Gubata, Marlene E. Packnett, Elizabeth R. Feng, Xiaoshu Cowan, David N. Niebuhr, David W. TI Pre-enlistment hearing loss and hearing loss disability among US soldiers and marines SO NOISE & HEALTH LA English DT Article DE Disability evaluation; hearing loss; military personnel ID UNITED-STATES; ARMY SOLDIERS; U.S. ARMY; CONSERVATION PROGRAM; NATIONAL-HEALTH; NOISE EXPOSURE; RISK-FACTORS; MILITARY; IMPAIRMENT; PERSONNEL AB Hearing loss is a common condition among US adults, with some evidence of increasing prevalence in young adults. Noise-induced hearing loss attributable to employment is a significant source of preventable morbidity world-wide. The US military population is largely comprised of young adult males serving in a wide variety of occupations, many in high noise-level conditions, at least episodically. To identify accession and service-related risk factors for hearing-related disability, matched case-control study of US military personnel was conducted. Individuals evaluated for hearing loss disability in the US Army and Marine Corps were frequency matched to controls without history of disability evaluation on service and enlistment year. Conditional logistic regression was used to examine the association between accession and service-related factors and hearing-related disability evaluations between October 2002 and September 2010. Individuals with medically disqualifying audiograms or hearing loss diagnoses at application for military service were 8 and 4 times more likely, respectively, to have a disability evaluation related to hearing loss, after controlling for relevant accession, demographic, and service-related factors. Conservative hearing loss thresholds on pre-enlistment audiograms, stricter hearing loss medical waiver policies or qualified baseline audiograms pre-enlistment are needed in the U.S military. Industrial corporations or labor unions may also benefit from identifying individuals with moderate hearing loss at the time of employment to ensure use of personal protective equipment and engineer controls of noise. C1 [Gubata, Marlene E.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, Silver Spring, MD 20910 USA. [Packnett, Elizabeth R.; Feng, Xiaoshu; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Marlene.Gubata@us.army.mil NR 39 TC 4 Z9 4 U1 1 U2 13 PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 1463-1741 J9 NOISE HEALTH JI Noise Health PD SEP-OCT PY 2013 VL 15 IS 66 BP 289 EP 295 DI 10.4103/1463-1741.116547 PG 7 WC Audiology & Speech-Language Pathology; Public, Environmental & Occupational Health SC Audiology & Speech-Language Pathology; Public, Environmental & Occupational Health GA 216DT UT WOS:000324262400001 PM 23955124 ER PT J AU Goffar, SL Reber, RJ Christiansen, BC Miller, RB Naylor, JA Rodriguez, BM Walker, MJ Teyhen, DS AF Goffar, Stephen L. Reber, Rett J. Christiansen, Bryan C. Miller, Robert B. Naylor, Jacob A. Rodriguez, Brittany M. Walker, Michael J. Teyhen, Deydre S. TI Changes in Dynamic Plantar Pressure During Loaded Gait SO PHYSICAL THERAPY LA English DT Article ID ARCH HEIGHT INDEX; MEASUREMENT SYSTEM; RISK-FACTORS; LOWER-LIMB; PARAMETERS; CARRIAGE; RUNNERS; WALKING; PAIN; FOOT AB Background. Lower extremity overuse injuries are detrimental to military readiness. Extremes of arch height and heavy loads carried by military personnel are associated with increased risk for overuse injury. Little is known regarding the impact of load carriage on plantar pressure distributions during gait. Objective. The objective of this study was to determine how load carriage affects plantar pressure distributions during gait in individuals with varying arch types. Design. A cross-sectional, repeated-measures design was used for the study. Methods. The study was performed at a research laboratory at Fort Sam Houston, Texas. Service members who were healthy and weighing >= 70 kg were enrolled in the study. The participants (97 men, 18, women; mean age=31.3 years, SD=5.6; mean weight=86.0 kg, SD=11.0) were categorized as having high-, normal-, or low-arched feet on the basis of published cutoff values for the arch height index. Plantar pressure measurements were obtained with the use of an in-shoe pressure measurement system while participants wore combat boots and walked on a treadmill under 3 loaded conditions (uniform, 20-kg load, and 40-kg load). Maximal force (MaxF) and force-time integral (FTI) were assessed with the use of a 9-sector mask to represent regions of the foot. A 3 X 3 repeated-measures analysis of variance was used for analysis across the levels of load and arch type. Results. A significant interaction existed between arch type and load for MaxF and FTI in the medial midfoot, with greater force in low-arched feet. In the medial forefoot, MaxF and FTI were greatest in high-arched feet across all load conditions. In the great toe region, low-arched and normally arched feet had greater MaxF and FTI. The relative distribution of FTI increased proportionately in all regions of the foot regardless of arch type for all load conditions. Limitations. The influence of fatigue, greater loads, and different walking speeds was not assessed. Conclusions. Regardless of arch type, increases in load did not alter the relative distribution of force over the plantar foot during gait. Participants with high-arched feet had greater force in the medial forefoot region, whereas those with normally arched or low-arched feet had greater force in the great toe region, regardless of load. These differences in force distribution may demonstrate different strategies to generate a rigid lever during toe-off. C1 [Goffar, Stephen L.; Naylor, Jacob A.] Landstuhl Reg Med Ctr, Rehabil Serv, Landstuhl, Germany. [Goffar, Stephen L.; Walker, Michael J.; Teyhen, Deydre S.] Baylor Univ, US Army, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Reber, Rett J.] Air Force Base Med Clin, Phys Therapy Clin, Scott Afb, IL USA. [Christiansen, Bryan C.] Blanchfield Army Community Hosp, Rehabil Serv, Ft Campbell, KY USA. [Miller, Robert B.] William Beaumont Army Med Ctr, Phys Therapy Sect, El Paso, TX 79920 USA. [Rodriguez, Brittany M.] Ft Belvoir Community Hosp, Dept Phys Therapy, Ft Belvoir, VA USA. [Walker, Michael J.] Evidence Mot, Schertz, TX USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Goffar, SL (reprint author), MCUEL LST DCS SG PT, Landstuhl Reg Med Ctr, CMR 402, APO, AE 09180 USA. EM stephen.goffar@amedd.army.mil FU Telemedicine and Advanced Technology Research Center (TATRC), US Army Medical Research and Material Command, Fort Detrick, Maryland FX This work was funded through the Bone Health Research Program, Telemedicine and Advanced Technology Research Center (TATRC), US Army Medical Research and Material Command, Fort Detrick, Maryland. NR 34 TC 2 Z9 4 U1 4 U2 31 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1175 EP 1184 DI 10.2522/ptj.20120103 PG 10 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700007 PM 23580629 ER PT J AU Scherer, MR Claro, PJ Heaton, KJ AF Scherer, Matthew R. Claro, Pedro J. Heaton, Kristin J. TI Sleep Deprivation Has No Effect on Dynamic Visual Acuity in Military Service Members Who Are Healthy SO PHYSICAL THERAPY LA English DT Article ID UNILATERAL VESTIBULAR HYPOFUNCTION; TRAUMATIC BRAIN-INJURY; VESTIBULOOCULAR REFLEX; EYELID MOVEMENTS; OCULAR REFLEX; REHABILITATION; RECOVERY; BLAST; RELIABILITY; AFGHANISTAN AB Background. The risk of traumatic brain injury (TBI) and comorbid posttraumatic dizziness is elevated in military operational environments. Sleep deprivation is known to affect a service member's performance while deployed, although little is known about its effects on vestibular function. Recent findings suggest that moderate acceleration step rotational stimuli may elicit a heightened angular vestibulo-ocular reflex (aVOR) response relative to low-frequency sinusoidal stimuli after 26 hours of sleep deprivation. There is concern that a sleep deprivation-mediated elevation in aVOR function could confound detection of comorbid vestibular pathology in service members with TBI. The term "dynamic visual acuity" (DVA) refers to an individual's ability to see clearly during head movement and is a behavioral measure of aVOR function. The Dynamic Visual Acuity Test (DVAT) assesses gaze instability by measuring the difference between head-stationary and head-moving visual acuity. Objective. The purpose of this study was to investigate the effects of 26 hours of sleep deprivation on DVA as a surrogate for aVOR function. Design. This observational study utilized a repeated-measures design. Methods. Twenty soldiers with no history of vestibular insult or head trauma were assessed by means of the DVAT at angular head velocities of 120 to 180 degrees/s. Active and passive yaw and pitch impulses were obtained before and after sleep deprivation. Results. Yaw DVA remained unchanged as the result of sleep deprivation. Active pitch DVA diminished by -0.005 LogMAR (down) and -0.055 LogMAR (up); passive pitch DVA was degraded by -0.06 LogMAR (down) and -0.045 LogMAR (up). Limitations. Sample homogeneity largely confounded accurate assessment of test-retest reliability in this study, resulting in intraclass correlation coefficients lower than those previously reported. Conclusions. Dynamic visual acuity testing in soldiers who are healthy revealed no change in gaze stability after rapid yaw impulses and subclinical changes in pitch DVA after sleep deprivation. Findings suggest that DVA is not affected by short-term sleep deprivation under clinical conditions. C1 [Scherer, Matthew R.; Claro, Pedro J.; Heaton, Kristin J.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. RP Scherer, MR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St, Natick, MA 01760 USA. EM matthew.scherer@us.army.mil FU Congressionally Directed Medical Research Programs (CDMRP) through an Advanced Technology Award [W81XWH-08-2-0,177]; US Army Medical Research and Materiel Command (USAMRMC) [W81XWH-08-1-0,021] FX This work was supported by Congressionally Directed Medical Research Programs (CDMRP) through an Advanced Technology Award (W81XWH-08-2-0,177) to Jamshid Ghajar and by the US Army Medical Research and Materiel Command (USAMRMC) through W81XWH-08-1-0,021 to Dr Heaton. NR 51 TC 2 Z9 2 U1 1 U2 12 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1185 EP 1196 DI 10.2522/ptj.20120144 PG 12 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700008 PM 23162043 ER PT J AU Teyhen, DS Childs, JD Dugan, JL Wright, AC Sorge, JA Mello, JL Marmolejo, MG Taylor, AY Wu, SS George, SZ AF Teyhen, Deydre S. Childs, John D. Dugan, Jessica L. Wright, Alison C. Sorge, Joshua A. Mello, Jeremy L. Marmolejo, Michael G. Taylor, Adam Y. Wu, Samuel S. George, Steven Z. TI Effect of Two Different Exercise Regimens on Trunk Muscle Morphometry and Endurance in Soldiers in Training SO PHYSICAL THERAPY LA English DT Article ID LOW-BACK-PAIN; LUMBAR MULTIFIDUS MUSCLE; RANDOMIZED CONTROLLED-TRIAL; CROSS-SECTIONAL AREA; CORE STABILIZATION EXERCISES; MOTOR CONTROL EXERCISE; PELVIC GIRDLE PAIN; LEG RAISE TEST; TRANSVERSUS ABDOMINIS; ELITE CRICKETERS AB Background. Limited evidence exists on how strength and endurance exercises commonly used to prevent low back pain affect muscle morphometry and endurance. Objective. The purpose of this study was to analyze the effects of 2 exercise regimens on the morphometry and endurance of key trunk musculature in a healthy population. Design. The study was designed as a randomized controlled trial. Setting. The study was conducted in a military training setting. Participants. A random subsample (n=340; 72% men, 28% women; mean [+/- SD] age=21.9 +/- 4.2 years; mean [ SD] body mass index=24.8 +/- 2.8 kg/m(2)) from the larger Prevention of Low Back Pain in the Military trial (N=4,325) was included. Intervention. The core stabilization exercise program (CSEP) included low-load/low-repetition motor control exercises, whereas the traditional exercise program (TEP) included exercises conducted at a fast pace, with the use of high-load, high-repetition trunk strengthening exercises. Measurements. Baseline and follow-up examinations included ultrasound imaging of the trunk muscles and endurance tests. Linear mixed models were fitted to study the group and time effect and their interactions, accounting for the clustering effect. Results. Symmetry generally improved in the rest and contracted states, but there were no differences suggestive of muscle hypertrophy or improved ability to contract the trunk muscles between soldiers receiving the CSEP or the TEP. Total trunk endurance time decreased over the 12-week period, but endurance performance favored soldiers in the CSEP group. Endurance time was not associated with future episodes of low back pain. Limitations. The lack of morphological changes may not be detectable in an already-active cohort, or a more intensive dose was needed. Conclusions. Although improved symmetry was noted, neither the CSEP nor the TEP resulted in muscle hypertrophy. Longer endurance times were noted in individuals who completed the CSEP but were not strongly predictive of future low back pain episodes. C1 [Childs, John D.] US Army Baylor Univ, Doctoral Program Phys Therapy, Biloxi, MI USA. [Childs, John D.] Keesler Air Force Base, Dept Phys Therapy, Biloxi, MI USA. [Dugan, Jessica L.] True Res Fdn, Dept Res, San Antonio, TX USA. [Wu, Samuel S.] Univ Florida, Dept Biostat, Gainesville, FL USA. [George, Steven Z.] Univ Florida, Brooks Ctr Rehabil Studies, Dept Phys Therapy, Gainesville, FL 32611 USA. RP Teyhen, DS (reprint author), US Army Med Dept Ctr & Sch, Dept Phys Therapy, 3150 Stanley Rd,Room 1303, Ft Sam Houston, TX 78234 USA. EM deydre.teyhen@amedd.army.mil FU Department of Defense [PR054098]; Fort Detrick, Maryland [W81XWH-06-1-0564] FX The Prevention of Low Back Pain in the Military trial is supported by the peer-reviewed medical research program of the Department of Defense (PR054098), Congressionally Directed Peer-Reviewed Medical Research Program (W81XWH-06-1-0564), Fort Detrick, Maryland. NR 61 TC 2 Z9 2 U1 3 U2 28 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1211 EP 1224 DI 10.2522/ptj.20120152 PG 14 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700010 PM 23064733 ER PT J AU Hoppes, CW Ross, MD Moore, JH AF Hoppes, Carrie W. Ross, Michael D. Moore, Josef H. TI Undetected Pectoralis Major Tendon Rupture in a Patient Referred to a Physical Therapist in a Combat Environment: A Case Report SO PHYSICAL THERAPY LA English DT Article ID MUSCLE; INJURIES; DIAGNOSIS; MANAGEMENT; MEDICINE; REPAIR AB Background and Purpose. This case report describes a patient. who was referred to a physical therapist for treatment of a shoulder strain and was eventually diagnosed with a rupture of the pectoralis major tendon that required surgical repair. The purpose of this case report is to highlight the management of this injury within the unique constraints of a combat environment. Case Description. A 29-year-old man, currently serving as an active duty soldier in the US Army in Iraq, had a sudden onset of right shoulder pain during the concentric portion of a bench press. He was seen by a physician immediately after the injury, diagnosed with a shoulder strain, and referred to a physical therapist for a sling and exercise instruction. On the basis of the history and physical examination findings, which were consistent with a pectoralis major tendon rupture, the physical therapist placed a consult to an orthopedic surgeon in the United States through teleconsultation because orthopedic surgeons were not easily accessible in Iraq for nonemergency musculoskeletal referrals. Subsequently, the orthopedic surgeon advised evacuating the patient out of Iraq for surgical treatment. Outcomes. By means of magnetic resonance imaging, the patient was diagnosed as having a rupture of the pectoralis major tendon at the musculotendinous junction near its insertion into the greater tubercle of the humerus that required surgical repair. At 3 months after surgery, the patient had full pain-free shoulder active range of motion and had progressed well through his strengthening program in a manner that allowed return to full duty. At 6 months after surgery, the patient maintained full duty status, was performing a routine of strength training 3 times per week, and had met all of his rehabilitation and personal goals. Discussion. Successful treatment of this patient depended on analysis of the history and physical examination findings by the physical therapist to form an accurate diagnosis. In addition, timely medical evacuation and referral to an orthopedic surgeon for surgical treatment were coordinated in a combat environment. Completion of a progressive rehabilitation program after pectoralis major tendon repair also contributed to this patient's full recovery and return to duty. Had the physical therapist only followed the initial referral request, given this patient's military duties and sports and recreational activities, this case probably would have resulted in suboptimal outcomes. C1 [Hoppes, Carrie W.; Moore, Josef H.] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Ross, Michael D.] Univ Scranton, Dept Phys Therapy, Scranton, PA 18510 USA. RP Hoppes, CW (reprint author), Army Med Dept Ctr & Sch, 3599 Winfield Scott Rd, Ft Sam Houston, TX 78234 USA. EM carrie.witherel@us.army.mil NR 29 TC 1 Z9 1 U1 0 U2 11 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1225 EP 1233 DI 10.2522/ptj.20120141 PG 9 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700011 PM 23086408 ER PT J AU Scherer, MR Weightman, MM Radomski, MV Davidson, LF McCulloch, KL AF Scherer, Matthew R. Weightman, Margaret M. Radomski, Mary V. Davidson, Leslie F. McCulloch, Karen L. TI Returning Service Members to Duty Following Mild Traumatic Brain Injury: Exploring the Use of Dual-Task and Multitask Assessment Methods SO PHYSICAL THERAPY LA English DT Article ID STABILITY FOLLOWING CONCUSSION; POSTURAL STABILITY; NATURALISTIC ACTION; ATTENTION DEFICITS; EXECUTIVE FUNCTION; ACTION IMPAIRMENT; HEAD-INJURY; GAIT; BALANCE; COMBAT AB Within the last decade, more than 220,000 service members have sustained traumatic brain injury asp in support of military operations in Iraq and Afghanistan. Mild TBI may result in subtle cognitive and sensorimotor deficits that adversely affect warfighter performance, creating significant challenges for service members, commanders, and clinicians. In recent conflicts, physical therapists and occupational therapists have played an important role in evaluating service member readiness to return to duty (RTD), incorporating research and best practices from the sports concussion literature. Because premorbid (baseline) performance metrics are not typically available for deployed service members as for athletes, clinicians commonly determine duty readiness based upon the absence of postconcussive symptoms and return to "normal" performance on clinical assessments not yet validated in the military population. Although practices described in the sports concussion literature guide "return-to-play" determinations, resolution of symptoms or improvement of isolated impairments may be inadequate to predict readiness in a military operational environment. Existing clinical metrics informing RTD decision making are limited because they fail to emphasize functional, warrior task demands and they lack versatility to assess the effects of comorbid deficits. Recently, a number of complex task-oriented RTD approaches have emerged from Department of Defense laboratory and clinical settings to address this gap. Immersive virtual reality environments, field-based scenario-driven assessment programs, and militarized dual-task and multitask-based approaches have all been proposed for the evaluation of sensorimotor and cognitive function following TBI. There remains a need for clinically feasible assessment methods that can be used to verify functional performance and operational competence in a variety of practice settings. Complex and ecologically valid assessment techniques incorporating dual-task and multitask methods may prove useful in validating return-to-activity requirements in civilian and military populations. C1 [Scherer, Matthew R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Weightman, Margaret M.; Radomski, Mary V.] Sister Kenny Res Ctr, Minneapolis, MN USA. [Davidson, Leslie F.] Shenandoah Univ, Dept Occupat Therapy, Winchester, VA USA. [McCulloch, Karen L.] Univ N Carolina, Chapel Hill, NC USA. RP Scherer, MR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St, Natick, MA 01760 USA. EM matthew.scherer@us.army.mil FU US Army Medical Research and Materiel Command [W81XWH-09-2-0149] FX The research team's ongoing investigation of dual-task and multitask testing methods in service members with mild traumatic brain injury is funded by the US Army Medical Research and Materiel Command (award number W81XWH-09-2-0149). NR 79 TC 6 Z9 6 U1 0 U2 13 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1254 EP 1267 DI 10.2522/ptj.20120143 PG 14 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700014 PM 23766395 ER PT J AU Moore, JH Goffar, SL Teyhen, DS Pendergrass, TL Childs, JD Ficke, JR AF Moore, Josef H. Goffar, Stephen L. Teyhen, Deydre S. Pendergrass, Timothy L. Childs, John D. Ficke, James R. TI The Role of US Military Physical Therapists During Recent Combat Campaigns SO PHYSICAL THERAPY LA English DT Article ID MANAGING-MUSCULOSKELETAL-CONDITIONS; OPERATIONS DESERT-SHIELD; DIAGNOSIS; KNOWLEDGE; FRACTURE; JOINT; STORM; TEAM; CARE; PAIN AB US military physical therapists have a proud history of providing medical care during operational deployments ranging from war to complex humanitarian emergencies. Regardless of austerity of environment or intensity of hostility, US military physical therapists serve as autonomous providers, evaluating and treating service members with and without physician referral. This perspective article suggests that the versatility of US military physical therapist practice enables them not only to diagnose musculoskeletal injuries but also to provide a wide range of definitive care and rehabilitation, reducing the need for costly evacuation. War is not sport, but the delivery of skilled musculoskeletal physical therapy services as close to the point of injury as possible parallels the sports medicine model for on- or near-field practice. This model that mixes direct access with near-immediate access enhances outcomes, reduces costs, and allows other health care team members to work at the highest levels of their licensure. C1 [Moore, Josef H.] US Army Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, Grad Sch, Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. [Goffar, Stephen L.] Landstuhl Reg Med Ctr, Rehabil Serv, Landstuhl, Germany. [Goffar, Stephen L.; Teyhen, Deydre S.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Pendergrass, Timothy L.] US Army Off, Surg Gen Allied Hlth Staff Off, Falls Church, VA USA. [Childs, John D.] Keesler Air Force Base, Med Grp 81, Dept Phys Therapy MSGS SGCUY, Biloxi, MS USA. [Ficke, James R.] San Antonio Mil Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX USA. RP Moore, JH (reprint author), US Army Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, Grad Sch, Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. EM josef.moore@us.army.mil NR 27 TC 1 Z9 2 U1 0 U2 12 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2013 VL 93 IS 9 SI SI BP 1268 EP 1275 DI 10.2522/ptj.20120136 PG 8 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 212OM UT WOS:000323992700015 PM 23641030 ER PT J AU Xu, XJ Karis, AJ Buller, MJ Santee, WR AF Xu, Xiaojiang Karis, Anthony J. Buller, Mark J. Santee, William R. TI Relationship between core temperature, skin temperature, and heat flux during exercise in heat SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Non-invasive measurement; Heat strain; Human; Heat transfer ID INDIVIDUAL CHARACTERISTICS; ILLNESS; STRESS; HUMANS; STRAIN; BODY AB This paper investigates the relationship between core temperature (T (c)), skin temperature (T (s)) and heat flux (HF) during exercise in hot conditions. Nine test volunteers, wearing an Army Combat Uniform and body armor, participated in three sessions at 25 A degrees C/50 % relative humidity (RH); 35 A degrees C/70 % RH; and 42 A degrees C/20 % RH. Each session consisted of two 1-h treadmill walks at similar to 350 W and similar to 540 W intensity. T (s) and HF from six sites on the forehead, sternum, pectoralis, left rib cage, left scapula, and left thigh, and T (c) (i.e., core temperature pill used as a suppository) were measured. Multiple linear regressions were conducted to derive algorithms that estimate T (c) from T (s) and HF at each site. A simple model was developed to simulate influences of thermal conductivity and thickness of the local body tissues on the relationship between T (c), T (s), and HF. Coefficient of determination (R (2)) ranged from 0.30 to 0.88, varying with locations and conditions. Good sites for T (c) measurement at surface were the sternum, and a combination of the sternum, scapula, and rib sites. The combination of T (s) and HF measured at the sternum explained similar to 75 % or more of variance in observed T (c) in hot environments. The forehead was found unsuitable for exercise in heat due to sweating and evaporative heat loss. The derived algorithms are likely applicable only for the same ensemble or ensembles with similar thermal and vapor resistances. Algorithms for T (c) measurement are location-specific and their accuracy is dependent, to a large degree, on sensor placement. C1 [Xu, Xiaojiang; Karis, Anthony J.; Buller, Mark J.; Santee, William R.] US Army, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Xu, XJ (reprint author), US Army, Biophys & Biomed Modeling Div, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM xiaojiang.xu@us.army.mil NR 31 TC 13 Z9 13 U1 2 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD SEP PY 2013 VL 113 IS 9 BP 2381 EP 2389 DI 10.1007/s00421-013-2674-z PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 204AA UT WOS:000323335400021 PM 23775374 ER PT J AU Pereira, NR Weber, BV Phipps, DG Schumer, JW Seely, JF Carroll, JJ Vanhoy, JR Slabkowska, K Polasik, M Szymanska, E Rzadkiewicz, J AF Pereira, Nino R. Weber, B. V. Phipps, D. G. Schumer, J. W. Seely, J. F. Carroll, J. J. Vanhoy, J. R. Slabkowska, K. Polasik, M. Szymanska, E. Rzadkiewicz, J. TI High-resolution (similar to 0.05%) red shift of a similar to 60 keV K beta line upon ionization SO HIGH ENERGY DENSITY PHYSICS LA English DT Article DE High-resolution spectroscopy; Plasma diagnostics; K-Edges ID PLASMA; POWER AB A recent measurement [1] demonstrates that iridium's K alpha(2)-line, centered at similar or equal to 63286.96 eV for a cold atom, increases similar or equal to+10 eV in energy when it is emitted by a modestly (similar to 17x) ionized plasma. This measurement, enabled by a near-coincident lutetium K-edge filter, agrees well with atomic physics computations. Not understood at the time was a similar measurement with a thulium filter at the similar or equal to 59370 eV energy of ytterbium's K beta(1) line, which indicated that its photon energy decreases with ionization. The computation reported here shows that the ionization energy shift for Yb's K beta lines is indeed negative and agrees qualitatively with the measurements. For the K-lines the ionization energy shift may be most interesting in atomic physics, while for the L-lines the ionization energy shift is a promising plasma diagnostic [2]. (C) 2013 Elsevier B.V. All rights reserved. C1 [Pereira, Nino R.] Ecopulse Inc, Springfield, VA 22152 USA. [Weber, B. V.; Phipps, D. G.; Schumer, J. W.] Naval Res Lab, Washington, DC 20375 USA. [Seely, J. F.] Artep Inc, Ellicott City, MD 21042 USA. [Carroll, J. J.] Army Res Lab, Adelphi, MD 20783 USA. [Vanhoy, J. R.] US Naval Acad, Annapolis, MD 21402 USA. [Slabkowska, K.; Polasik, M.; Szymanska, E.] Nicholas Copernicus Univ, Fac Chem, PL-87100 Torun, Poland. [Rzadkiewicz, J.] Natl Ctr Nucl Studies, PL-01497 Warsaw, Poland. RP Pereira, NR (reprint author), Ecopulse Inc, Springfield, VA 22152 USA. EM ninorpereira@gmail.com RI Slabkowska, katarzyna/O-8760-2015 FU DTRA through ARL [W911QX09D0016]; DTRAs Basic-Research-Sciences MIPR [08-2468, MIPR 09-2156]; NRL; Polish National Science Centre [2011/01/D/ST2/01286] FX This work was supported by DTRA through ARL contract W911QX09D0016 to Ecopulse, DTRAs Basic-Research-Sciences MIPR 08-2468 and MIPR 09-2156 with NRL, and the Polish National Science Centre under grant no. 2011/01/D/ST2/01286. NR 18 TC 6 Z9 6 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1574-1818 J9 HIGH ENERG DENS PHYS JI High Energy Density Phys. PD SEP PY 2013 VL 9 IS 3 BP 500 EP 504 DI 10.1016/j.hedp.2013.03.011 PG 5 WC Physics, Fluids & Plasmas SC Physics GA 210SP UT WOS:000323855100020 ER PT J AU Noh, JY Cheong, HJ Song, JY Kim, WJ Song, KJ Klein, TA Lee, SH Yanagihara, R Song, JW AF Noh, Ji Yun Cheong, Hee Jin Song, Joon Young Kim, Woo Joo Song, Ki-Joon Klein, Terry A. Lee, Sam H. Yanagihara, Richard Song, Jin-Won TI Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Hantaan virus; Hantavirus; Hemorrhagic fever with renal syndrome; Korea ID HANTAAN VIRUS SURVEILLANCE; REPUBLIC-OF-KOREA; NEPHROPATHIA-EPIDEMICA; GYEONGGI PROVINCE; ETIOLOGIC AGENT; SMALL MAMMALS; HANTAVIRUS; INFECTION AB Background: Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives: To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design: Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results: Among 35 HFRS patients (mean age was 44.2 +/- 14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09-97.77, P=.04) and initial serum albumin less than 3 g/dL (OR 22.83, 95% CI 1.45-359.93, P=.03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions: HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea. (C) 2013 Elsevier B. V. All rights reserved. C1 [Noh, Ji Yun; Song, Ki-Joon; Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. [Cheong, Hee Jin; Song, Joon Young; Kim, Woo Joo] Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul 152703, South Korea. [Klein, Terry A.; Lee, Sam H.] US Army MEDDAC Korea, Unit 15281, Med Brigade 65, APO, AP 96205 USA. [Yanagihara, Richard] Univ Hawaii Manoa, Dept Pediat, John A Burns Sch Med, Honolulu, HI 96813 USA. [Yanagihara, Richard] Univ Hawaii Manoa, John A Burns Sch Med, Dept Trop Med Med Microbiol & Pharmacol, Honolulu, HI 96813 USA. RP Song, JW (reprint author), Korea Univ, Coll Med, Dept Microbiol, Anam Dong 5-Ga, Seoul 136705, South Korea. EM jwsong@korea.ac.kr RI Kim, Woo Joo/D-2733-2015; OI Kim, Woo Joo/0000-0002-4546-3880; Song, Ki-Joon/0000-0002-7935-3719 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01AI075057]; Korea Healthcare technology R&D Project Ministry of Health & Welfare Republic of Korea [A103001]; Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System [AFHSC-GEIS], Silver Spring, MD FX This work was supported in part by the National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01AI075057], the Korea Healthcare technology R&D Project Ministry of Health & Welfare Republic of Korea (Grant No.: A103001) and the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System [AFHSC-GEIS], Silver Spring, MD. NR 27 TC 6 Z9 6 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD SEP PY 2013 VL 58 IS 1 BP 11 EP 17 DI 10.1016/j.jcv.2013.06.027 PG 7 WC Virology SC Virology GA 206ZB UT WOS:000323564500003 PM 23871164 ER PT J AU Ford, KB Collins, MK Ajami, NE Dowds, D Mesyef, K Trovillion, J Al-Chaar, G Marsh, CP AF Ford, Kyle B. Collins, Michael K. Ajami, Nassim E. Dowds, Dominick Mesyef, Kevin Trovillion, Jonathan Al-Chaar, Ghassan Marsh, Charles P. TI Optical response to low applied pressure in a quantum dot nanocomposite SO MATERIALS LETTERS LA English DT Article DE Nanocomposites; Sensors; Quantum Dot; Pressure; Fluorescence ID STRESS AB Recent discoveries of pressure dependence in quantum dot (QD) fluorescence wavelength has led to work pursuing QD-based systems for strain and pressure-sensing applications. However, the spectral shift of QDs tends to be fairly insensitive, typically requiring applied pressure on the order of gigapascals before any change can be detected. We present a QD-epoxy nanocomposite whose spectral intensity response to pressure can be used to quantitatively detect pressure changes in the megapascal range. The intensity of QD fluorescence is compared to the intensity of a reference to provide meaningful intensity data, which provides a bright signal that is quantitatively indicative of material stress. We believe that further optimization and characterization of this nanocomposite may be useful in the development of sensitive optical strain sensors. (C) 2013 Elsevier B.V. All rights reserved. C1 [Ford, Kyle B.; Collins, Michael K.; Ajami, Nassim E.; Dowds, Dominick; Mesyef, Kevin; Trovillion, Jonathan; Al-Chaar, Ghassan; Marsh, Charles P.] CERL ERDC, Champaign, IL 61820 USA. RP Ford, KB (reprint author), CERL ERDC, Champaign, IL 61820 USA. EM Kyle.B.Ford@usace.army.mil FU Army Corps of Engineers through US Army Research, Development, Test & Evaluation (RDT&E) Program Element 6.1, "Basic Research" FX This investigation was funded by the Army Corps of Engineers through US Army Research, Development, Test & Evaluation (RDT&E) Program Element 6.1, "Basic Research". This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Engineer Research and Development Center, Construction Engineering Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ERDC-CERL. NR 5 TC 5 Z9 6 U1 0 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD SEP 1 PY 2013 VL 106 BP 301 EP 303 DI 10.1016/j.matlet.2013.05.045 PG 3 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 195DM UT WOS:000322682500080 ER PT J AU Wong, B Perkins, MW Santos, MD Rodriguez, AM Murphy, G Sciuto, AM AF Wong, Benjamin Perkins, Michael W. Santos, Mariton D. Rodriguez, Ashley M. Murphy, Gleeson Sciuto, Alfred M. TI Development of a model for nerve agent inhalation in conscious rats SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Chemical warfare; cholinesterases; inhalation exposure; nerve agents; organophosphates; vapor ID ACETYLCHOLINESTERASE INHIBITION; EXPOSURE CONCENTRATION; VAPOR; TOXICITY; SARIN; SOMAN; GF; TOXICOLOGY; DURATION; ANIMALS AB This study characterizes the development of a head-out inhalation exposure system for assessing respiratory toxicity of vaporized chemical agents in untreated, non-anesthetized rats. The organophosphate diisopropyl fluorophosphate (DFP) induces classical cholinergic toxicity following inhalation exposure and was utilized to validate the effectiveness of this newly designed inhalation exposure system. A saturator cell apparatus was used to generate DFP vapor at 9750, 10 950, 12 200, 14 625 and 19 500 mg x min/m(3) which was carried by filtered nitrogen into a glass mixing tube, where it combined with ambient air before being introduced to the custom-made glass exposure chamber. Male Sprague-Dawley rats (250-300 g) were restrained in individual head-out plethysmography chambers, which acquired respiratory parameters before, during and after agent exposure. All animals were acclimated to the exposure system prior to exposure to reduce novel environment-induced stress. The LCt(50), as determined by probit analysis, was 12 014 mg x min/m(3). Weight loss in exposed animals was dose-dependent and ranged from 8 to 28% of their body weight 24 h after exposure. Increased salivation, lacrimation, urination, defecation (SLUD) and mild muscular fasciculation were observed in all DFP-exposed animals during and immediately following exposure. In all exposed animals, DFP vapor produced significant inhibition of acetylcholinesterase (AChE) activity in cardiac blood, bronchoalveolar lavage fluid (BALF), whole brain and lung tissue as well as alterations in tidal volume and minute volume. These studies have provided valuable information leading to the initiation of studies evaluating inhalational toxicity and treatments following exposure to the more lethal and potent chemical warfare nerve agents. C1 [Wong, Benjamin; Perkins, Michael W.; Santos, Mariton D.; Rodriguez, Ashley M.; Murphy, Gleeson; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Sciuto, AM (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM alfred.mario.sciuto@us.army.mil FU Defense Threat Reduction Agency [3.F0014_09_RC_C] FX The work was supported by the Defense Threat Reduction Agency [3.F0014_09_RC_C]. This research was performed while the author (BW) held a National Research Council Research Associateship Award at USAMRICD. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 39 TC 5 Z9 5 U1 0 U2 17 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD SEP PY 2013 VL 23 IS 7 BP 537 EP 547 DI 10.3109/15376516.2013.796033 PG 11 WC Toxicology SC Toxicology GA 211WU UT WOS:000323943300008 PM 23581557 ER PT J AU Garrison, AR Radoshitzky, SR Kota, KP Pegoraro, G Ruthel, G Kuhn, JH Altamura, LA Kwilas, SA Bavari, S Haucke, V Schmaljohn, CS AF Garrison, Aura R. Radoshitzky, Sheli R. Kota, Krishna P. Pegoraro, Gianluca Ruthel, Gordon Kuhn, Jens H. Altamura, Louis A. Kwilas, Steven A. Bavari, Sina Haucke, Volker Schmaljohn, Connie S. TI Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway SO VIROLOGY LA English DT Article DE Bunyavirus; CCHF; Crimean-Congo hemorrhagic fever; Nairovirus; Virus entry ID RECEPTOR-MEDIATED ENDOCYTOSIS; CELL-FUSION; CONFORMATIONAL-CHANGES; MAMMALIAN-CELLS; HOST-CELLS; GLYCOPROTEIN; PSEUDOVIRIONS; ACIDIFICATION; REPLICATION; TRAFFICKING AB The early events in Crimean-Congo hemorrhagic fever virus (CCHFV) have not been completely characterized. Earlier work indicated that CCHFV likely enters cells by clathrin-mediated endocytosis (CME). Here we provide confirmatory evidence for CME entry by showing that CCHFV infection is inhibited in cells treated with Pitstop 2, a drug that specifically and reversibly interferes with the dynamics of clathrin-coated pits. Additionally, we show that CCHFV infection is inhibited by siRNA depletion of the clathrin pit associated protein AP-2. Following CME entry, we show that CCHFV has a pH-dependent entry step, with virus inactivation occurring at pH 6.0 and below. To more precisely define the endosomal trafficking of CCHFV, we show for the first time that overexpression of the dominant negative forms of Rab5 protein but not Rab7 protein inhibits CCHFV infection. These results indicate that CCHFV likely enters cells through the early endosomal compalunent. Published by Elsevier Inc. C1 [Garrison, Aura R.; Radoshitzky, Sheli R.; Kota, Krishna P.; Pegoraro, Gianluca; Ruthel, Gordon; Altamura, Louis A.; Kwilas, Steven A.; Bavari, Sina; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Ft Detrick, MD USA. [Haucke, Volker] Leibniz Inst Mol Pharmakol FMP, Berlin, Germany. RP Schmaljohn, CS (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD USA. EM connie.schmaljohn@us.army.mil RI Kuhn, Jens H./B-7615-2011; OI Kuhn, Jens H./0000-0002-7800-6045; Pegoraro, Gianluca/0000-0003-2843-9464; Haucke, Volker/0000-0003-3119-6993 FU Military Infectious Diseases Research Program; NIAID [HHSN272200200016I]; German Funding Agency DFG [SFB765/B04] FX This work was funded by the Military Infectious Diseases Research Program. JHK performed this work as an employee of Tunnell Government Services, a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract no. HHSN272200200016I. V.H. gratefully acknowledges support by the German Funding Agency DFG (SFB765/B04). NR 60 TC 18 Z9 18 U1 0 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP PY 2013 VL 444 IS 1-2 BP 45 EP 54 DI 10.1016/j.virol.2013.05.030 PG 10 WC Virology SC Virology GA 210ZJ UT WOS:000323873600007 PM 23791227 ER PT J AU Chapman, JL Lucas, R Lee, J Grimes, SS Porter, AM Bussey, A AF Chapman, Jamie L. Lucas, Rob Lee, Jessica Grimes, Stephanie S. Porter, Amy M. Bussey, Abby TI Implementation of inpatient blood glucose monitoring by clinical pharmacists SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material C1 [Chapman, Jamie L.; Lucas, Rob; Grimes, Stephanie S.; Porter, Amy M.; Bussey, Abby] Blount Mem Hosp, Dept Pharm, Maryville, TN 37804 USA. [Lee, Jessica] Walter Reed Army Med Ctr, Bethesda, MD USA. RP Chapman, JL (reprint author), Blount Mem Hosp, Dept Pharm, 907 East Lamar Alexander Pkwy, Maryville, TN 37804 USA. EM jlchapma@bmnet.com NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD SEP 1 PY 2013 VL 70 IS 17 BP 1480 EP 1481 DI 10.2146/ajhp120715 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 210BH UT WOS:000323803800009 PM 23943178 ER PT J AU Jarzemsky, RD Burchell, MR Evans, RO AF Jarzemsky, Robert D. Burchell, Michael R., II Evans, Robert O. TI The impact of manipulating surface topography on the hydrologic restoration of a forested coastal wetland SO ECOLOGICAL ENGINEERING LA English DT Article DE Wetland hydrology; Restoration; Microtopography ID CREATED MITIGATION WETLANDS; NORTH-CAROLINA; MICROTOPOGRAPHY; RESPONSES; PLANT AB A wetland, converted to agriculture in the mid-1970s, was restored to re-establish a non-riverine wet hardwood forest community in eastern North Carolina. Three surface techniques were implemented during construction to determine their effect on successfully restoring target wetland hydrology. The surface treatments, replicated within a randomized complete block design, were: plugging field ditches without altering the land surface (PLUG), plugging the field ditches and roughening the surface (ROUGH), and plugging the field ditches and removing the field crown (CR). Hydrologic conditions for the restoration and a nearby reference site were evaluated based on three years of monitoring data. Daily water table depths between the restoration and reference were within 11 cm on average. An initial evaluation found inconsistencies of treatment effect between blocks, and an as-built survey later confirmed surface elevations within Block 3 deviated from the intended design and was excluded from further analysis. Water table and outflow conditions for the remaining treatment plots and the reference were evaluated using several hydrologic criteria. The CR treatment was found to produce the wettest surface conditions and exported the lowest volume of outflow. For the majority of criterion considered, CR also produced significantly wetter conditions than the reference. The PLUG and ROUGH treatments produced similar hydrologic conditions and tracked closely with the median hydrologic conditions in the reference. Based on the results of this study and several others in low lying coastal areas, plugging pre-existing field ditches may be adequate to restore jurisdictional wetland hydrology and match reference hydrologic conditions. However, surface roughening is low cost method to increase surface storage and introduce microtopographic diversity. For many areas, the removal of existing field crown may be cost-prohibitive and produce wetter than desired conditions. Crown removal should be reserved for sites which have borderline historic wetland hydrologic characteristics. (C) 2013 Elsevier B.V. All rights reserved. C1 [Jarzemsky, Robert D.] US Army Corps Engineers, Chicago, IL 60606 USA. [Burchell, Michael R., II; Evans, Robert O.] N Carolina State Univ, Raleigh, NC 27695 USA. RP Burchell, MR (reprint author), N Carolina State Univ, Biol & Agr Engn Campus,Box 7625, Raleigh, NC 27695 USA. EM mikeburchell@ncsu.edu FU NC Department of Environment and Natural Resources - Ecosystem Enhancement Program FX The authors wish to thank the NC Department of Environment and Natural Resources - Ecosystem Enhancement Program for supporting this research. The North Carolina Coastal Federation was instrumental in supporting our efforts at their North River Farms restoration site. Special thanks to the NC State University Bio&Ag Engineering staff, graduate, and undergraduate students that supported well installation, site maintenance, and field data collection during the project. NR 24 TC 3 Z9 3 U1 6 U2 41 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD SEP PY 2013 VL 58 BP 35 EP 43 DI 10.1016/j.ecoleng.2013.06.002 PG 9 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 207OD UT WOS:000323610200006 ER PT J AU Mitchell, BL Rockwood, GA Logue, BA AF Mitchell, Brendan L. Rockwood, Gary A. Logue, Brian A. TI Quantification of alpha-ketoglutarate cyanohydrin in swine plasma by ultra-high performance liquid chromatography tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE alpha-Ketoglutarate cyanohydrin; Liquid chromatography tandem; mass-spectrometry; Cyanide; Method development; Biomarkers ID METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; CYANIDE EXPOSURE; BLOOD CYANIDE; HYDROXOCOBALAMIN; CYANOCOBALAMIN; THIOCYANATE; NONSMOKERS; SMOKERS; EFFICACY AB Determination of exposure to cyanide can be accomplished by direct cyanide analysis or indirectly by analysis of cyanide detoxification products, such as thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid. A potentially important marker and detoxification product of cyanide exposure, alpha-ketoglutarate cyanohydrin (alpha-KgCN), is produced by the reaction of cyanide and alpha-ketoglutarate. Therefore, an ultra high-performance liquid chromatography tandem mass spectrometry method to determine alpha-KgCN in plasma was developed. Swine plasma was spiked with alpha-KgCN and alpha-KgCN-d(4) (internal standard) and proteins were precipitated with 1% formic acid in acetonitrile. After centrifugation, the supernatant was dried, reconstituted, separated by reversed phase high performance liquid chromatography and analyzed by tandem mass spectrometry. The method produced a dynamic range of 0.3-50 mu M and a detection limit of 200 nM for alpha-KgCN. Furthermore, the method produced a %RSD of less than 13% for all intra- and inter-assay analyses. The stability of alpha-KgCN was poor for most storage conditions tested, except for -80 degrees C, which produced stable concentrations of alpha-KgCN for the 30 days tested. The validated method was tested by analysis of alpha-KgCN in the plasma of cyanide-exposed swine. alpha-KgCN was not detected pre-exposure, but was detected in all post-exposure plasma samples tested. To our knowledge, this method is the first reported analytical method for detecting alpha-KgCN in any matrix. (C) 2013 Elsevier B.V. All rights reserved. C1 [Mitchell, Brendan L.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), SDSU, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu FU CounterACT Program, National Institutes of Health Office; National Institute of Allergy and Infectious Diseases, Interagency [Y1-OD-0690-01/A-120-B.P2010-01, Y1-OD-1561-01/A120-B.P2011-01, AOD12060-001-00000/A120-B.P2012-01]; US Army Research Office of Scientific Services Program [W911NF-11-D-0001]; Battelle [TCN 11077, 0079]; Oak Ridge Institute for Science and Education (ORISE); U.S. Dept. of Education, Graduate Assistance in Areas of National Need (GAANN) [P200A100103]; National Science Foundation Major Research Instrumentation Program [CHE-0922816]; state of South Dakota; South Dakota State University [AB SCIEX QTRAP 5500 LC/MS/MS]; Department of Chemistry Biochemistry [P200A100103] FX The research was supported by the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Allergy and Infectious Diseases, Interagency Agreement Numbers Y1-OD-0690-01/A-120-B.P2010-01, Y1-OD-1561-01/A120-B.P2011-01, AOD12060-001-00000/A120-B.P2012-01 and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program Contract No. W911NF-11-D-0001 administered by Battelle (Delivery order 0079, Contract No. TCN 11077). We gratefully acknowledge the funding from the Oak Ridge Institute for Science and Education (ORISE) and the support from a U.S. Dept. of Education, Graduate Assistance in Areas of National Need (GAANN), award to the Department of Chemistry & Biochemistry (P200A100103). We thank the National Science Foundation Major Research Instrumentation Program (Grant Number CHE-0922816), the state of South Dakota, and South Dakota State University for funding the AB SCIEX QTRAP 5500 LC/MS/MS. The authors would like to acknowledge Dr. George Perry, Animal and Range Science (South Dakota State University) for providing swine plasma. Furthermore, the authors are thankful to Dr. Vikhyat Bebarta, Susan M. Boudreau, RN, BSN, Maria G. Castaneda, MS, Toni E. Vargas, PA-C, MHS, and Patricia Dixon, MHS from the Clinical Research Division, Wilford Hall Medical Center (Lackland Air Force Base, San Antonio, TX) for providing potassium cyanide-exposed swine plasma. The opinions or assertions NR 35 TC 0 Z9 0 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD SEP 1 PY 2013 VL 934 BP 60 EP 65 DI 10.1016/j.jchromb.2013.06.029 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 207IC UT WOS:000323591100010 PM 23900126 ER PT J AU Dua, A Via, KC Kreishman, P Kragh, JF Spinella, PC Patel, B Gillespie, DL Mahoney, P Fox, CJ AF Dua, Anahita Via, Katherine C. Kreishman, Peter Kragh, John F., Jr. Spinella, Philip C. Patel, Bhavin Gillespie, David L. Mahoney, Peter Fox, Charles J. TI Early management of pediatric vascular injuries through humanitarian surgical care during US military operations SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 96th Annual Clinical Congress of the American-College-of-Surgeons (ACS) / Owen H. Wangensteen Surgical Forum CY OCT 03-07, 2010 CL Washington, DC SP Amer Coll Surg (ACS) ID DAMAGE-CONTROL RESUSCITATION; TRAUMATIC INJURIES; CONTROL ADJUNCT; GLOBAL WAR; CHILDREN; MORTALITY; CASUALTIES; SURVIVAL; SURGERY; SHUNTS AB Background: The objective of this report is to describe our experience of pediatric vascular injuries in a U. S. military combat support hospital in Baghdad, Iraq. A retrospective study was designed using Joint Theater Trauma Registry (JTTR) records in order to evaluate the pediatric (age <18 years) population presenting with vascular trauma to a combat hospital in Baghdad, Iraq between April 2006 and August 2008. Demographic data comprised casualty, age, gender, and mechanism of injury. Physiologic data included presenting vital signs (rectal temperature, blood pressure, and heart rate), arterial pH, base deficit, hemoglobin (g/dL), and international normalized ratio. Results: Twenty-five children, median age 14 years (range, 5-17 years), median weight 48 kg (range, 15-80 kg) sustained 18 (72%) blast and 7 (28%) gunshot wounds. The mean Injury Severity Score was 25 +/- 16.2. The median operative time for the vascular repairs was 189 minutes (range, 41-505 minutes). Patients were tachycardic (mean +/- standard deviation, 136 +/- 29 bpm), hypotensive (109/63 +/- 29/19 mm Hg), and acidemic (pH 7.26 +/- 0.07; BD -5.57 +/- 5.1 mEq/L) on arrival to the emergency department and were physiologically improved upon admission to the intensive care unit 3 hours later. Repair techniques were ligation (14; 39%), saphenous graft (11; 31%), lateral suture (7; 19%), end anastomosis (2; 5%), patch (1; 3%), and thrombectomy (1; 3%). Twenty-four hour mean transfusion requirements included crystalloid 102 mL/kg (range, 19-253), transfused blood 47 mL/kg (range, 0-119), fresh frozen plasma 14 mL/kg (range, 0-68), and apheresis platelets (1.2 +/- 3.68 units). Over a follow-up of 22 +/- 5.5 days, the amputation-free survival was 80%. Conclusions: This is the largest reported wartime series to demonstrate in children that damage control resuscitation despite high injury severity permits simultaneous limb salvage. C1 [Dua, Anahita] Univ Texas Houston, Dept Surg, Med Ctr, Ctr Translat Injury Res CeTIR, Houston, TX USA. [Dua, Anahita] Univ Texas Houston, Dept Surg, Med Ctr, Houston, TX USA. [Via, Katherine C.; Kreishman, Peter; Patel, Bhavin; Fox, Charles J.] Walter Reed Army Med Ctr, Div Vasc Surg, Dept Surg, Bethesda, MD USA. [Kreishman, Peter; Fox, Charles J.] Uniformed Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD USA. [Kragh, John F., Jr.; Spinella, Philip C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Spinella, Philip C.] Washington Univ, Sch Med, Dept Pediat, St Louis Childrens Hosp,Div Crit Care, St Louis, MO 63110 USA. [Gillespie, David L.] Univ Rochester, Dept Surg, Div Vasc Surg, Rochester, NY USA. [Mahoney, Peter] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England. RP Fox, CJ (reprint author), Univ Colorado, Sch Med, 777 Bannock St,MC 0206, Denver, CO 80204 USA. EM foxvascular@gmail.com OI Patel, Bhavin/0000-0002-0877-1067; Gillespie, David/0000-0002-4378-9465 NR 26 TC 5 Z9 5 U1 0 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD SEP PY 2013 VL 58 IS 3 BP 695 EP 700 DI 10.1016/j.jvs.2013.02.034 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 207QG UT WOS:000323616800017 PM 23683379 ER PT J AU Ramirez, ALB Kean, ZS Orlicki, JA Champhekar, M Elsakr, SM Krause, WE Craig, SL AF Ramirez, Ashley L. Black Kean, Zachary S. Orlicki, Joshua A. Champhekar, Mangesh Elsakr, Sarah M. Krause, Wendy E. Craig, Stephen L. TI Mechanochemical strengthening of a synthetic polymer in response to typically destructive shear forces SO NATURE CHEMISTRY LA English DT Article ID MECHANICAL FORCE; DEGRADATION; KINETICS; MACROMOLECULES; DEFORMATION; ULTRASOUND; EXTENSION; BACKBONE; FRACTURE; GELATION AB High shear stresses are known to trigger destructive bond-scission reactions in polymers. Recent work has shown that the same shear forces can be used to accelerate non-destructive reactions in mechanophores along polymer backbones, and it is demonstrated here that such mechanochemical reactions can be used to strengthen a polymer subjected to otherwise destructive shear forces. Polybutadiene was functionalized with dibromocyclopropane mechanophores, whose mechanical activation generates allylic bromides that are crosslinked in situ by nucleophilic substitution reactions with carboxylates. The crosslinking is activated efficiently by shear forces both in solvated systems and in bulk materials, and the resulting covalent polymer networks possess moduli that are orders-of-magnitude greater than those of the unactivated polymers. These molecular-level responses and their impact on polymer properties have implications for the design of materials that, like biological materials, actively remodel locally as a function of their physical environment. C1 [Ramirez, Ashley L. Black; Kean, Zachary S.; Elsakr, Sarah M.; Craig, Stephen L.] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Orlicki, Joshua A.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Champhekar, Mangesh; Krause, Wendy E.] N Carolina State Univ, Dept Text Engn Chem & Sci, Raleigh, NC 27695 USA. RP Ramirez, ALB (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM stephen.craig@duke.edu RI Craig, Stephen/D-3484-2011 OI Craig, Stephen/0000-0002-8810-0369 FU US Army Research Laboratory; Army Research Office [W911NF-07-1-0409]; National Science Foundation [DMR-1122483]; Department of Defense Science, Mathematics and Research for Transformation Fellowship; National Institutes of Health NIGMS Biotechnology Predoctoral Training Grant [T32GM8555] FX This material is based on work supported by the US Army Research Laboratory and the Army Research Office under Grant W911NF-07-1-0409 and the National Science Foundation (DMR-1122483). A. L. B. R. was supported by a Department of Defense Science, Mathematics and Research for Transformation Fellowship and Z.S.K. by a National Institutes of Health NIGMS Biotechnology Predoctoral Training Grant (T32GM8555). NR 35 TC 53 Z9 54 U1 12 U2 149 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1755-4330 J9 NAT CHEM JI Nat. Chem. PD SEP PY 2013 VL 5 IS 9 BP 757 EP 761 DI 10.1038/NCHEM.1720 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA 207QF UT WOS:000323616700011 PM 23965677 ER PT J AU Bish, DR Chamberlayne, EP Rakha, HA AF Bish, Douglas R. Chamberlayne, Edward P. Rakha, Hesham A. TI Optimizing Network Flows with Congestion-Based Flow Reductions SO NETWORKS & SPATIAL ECONOMICS LA English DT Article DE Cell Transmission Model (CTM); Mixed binary programming; Time-expanded network flows; Congestion; Evacuation planning/modeling ID CELL TRANSMISSION MODEL; DYNAMIC TRAFFIC ASSIGNMENT; FREEWAY BOTTLENECKS; OPTIMIZATION MODEL; EVACUATION; STRATEGIES; CALIBRATION; FORMULATION; HIGHWAY; WAVES AB When optimizing traffic systems using time-expanded network flow models, traffic congestion is an important consideration because it can decrease both the discharge traffic flow rate and speed. One widely used modeling framework is the Cell Transmission Model (CTM) (see Daganzo, Transp Res-B 28(4):269-287, 1994, Transp Res-B 29(2):79-93, 1995), which is implemented in a linear program (LP) in Ziliaskopoulos (Transp Sci 34(1):37-49, 2000). While the CTM models the reduction in speed associated with congestion and the backward propagation of congestion, it does not properly model the reduction in discharge flow from a bottleneck after the onset of congestion. This paper discusses this issue and proposes a generalization of the CTM that takes into account this important phenomena. Plainly, an optimization that does not consider this important negative result of congestion can be problematic, e.g., in an evacuation setting such an optimization would assume that congestion does not impact network clearance time, which can result in poor evacuation strategies. In generalizing the CTM, a fairly simple modification is made, yet it can have significant impacts on the results. For instance, we show that for the generalized CTM the traffic holding (a result of the linearization of the CTM flow constraints) plays a more harmful role, which thus requires a scheme to eliminate traffic holding. In this paper, we propose a mixed binary program to eliminate traffic holding, along with methods to improve solvability. C1 [Bish, Douglas R.] Virginia Tech, Grado Dept Ind & Syst Engn 0118, Blacksburg, VA 24061 USA. [Chamberlayne, Edward P.] US Army Corps Engineers, Charleston, SC 29403 USA. [Rakha, Hesham A.] Virginia Tech, Charles E Via Jr Dept Civil & Environm Engn 0105, Blacksburg, VA 24061 USA. RP Bish, DR (reprint author), Virginia Tech, Grado Dept Ind & Syst Engn 0118, Blacksburg, VA 24061 USA. EM drb1@vt.edu FU Simulation and Optimization Laboratory in the Grado Department of Industrial and Systems Engineering at Virginia Tech; National Science Foundation [0825611, 1055360]; Mid-Atlantic University Transportation Center (MAUTC) FX The computational work was performed with support from the Simulation and Optimization Laboratory in the Grado Department of Industrial and Systems Engineering at Virginia Tech. This work has been partially supported by the National Science Foundation under Grant Number 0825611 and 1055360 and the Mid-Atlantic University Transportation Center (MAUTC). The authors also thank two anonymous reviewers for their constructive suggestions that have helped improve this paper. NR 46 TC 3 Z9 3 U1 3 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1566-113X J9 NETW SPAT ECON JI Netw Spat. Econ. PD SEP PY 2013 VL 13 IS 3 BP 283 EP 306 DI 10.1007/s11067-012-9181-3 PG 24 WC Operations Research & Management Science; Transportation Science & Technology SC Operations Research & Management Science; Transportation GA 208KG UT WOS:000323676800003 ER PT J AU Caplan, TR Cothern, K Landers, C Hummel, OC AF Caplan, Todd R. Cothern, Kristin Landers, Cliff Hummel, Ondrea C. TI Growth Response of Coyote Willow (Salix exigua) Cuttings in Relation to Alluvial Soil Texture and Water Availability SO RESTORATION ECOLOGY LA English DT Article DE live stakes; revegetation; riparian restoration; willow habitat ID RIPARIAN VEGETATION; FOREST ECOSYSTEMS; RIVER; RESTORATION; SURVIVAL; DECLINE; COTTONWOODS; FLOWS; NIGRA; TOLERANCES AB A common approach to re-establishing cottonwood-willow habitat along regulated rivers is through installing dormant, rootless cuttings, yet there is little published information exploring floodplain characteristics that optimize growth of southwestern riparian willows planted in this manner. The goal of this project was to evaluate relationships between growth attributes of Salix exigua and soil texture and soil water availability. Monitoring plots were established in five willow swales planted with dormant S.exigua cuttings along the banks of the Middle Rio Grande in central New Mexico. Data analysis revealed significantly higher aerial cover, height, and stem density for S. exigua plants installed in plots with intermediate levels (15-25%) of fine textured soils distributed through the soil profile. Similar relationships were found in relation to soil water availability. Regression analysis of percent fines and available water at different depth increments provided limited explanation of variability in willow growth attributes at different plots. Findings indicate that S. exigua plants established from cuttings can achieve heights and aerial cover values similar to naturally established willow bars if the floodplain soil profile contains intermediate levels of fine textured soils and the maximum depth to groundwater is within 1.5 m of the ground surface. Where sites are dominated by coarse sand, S. exigua growth may be improved if maximum depth to groundwater is within 1 m of the ground surface. C1 [Caplan, Todd R.] GeoSyst Anal Inc, Albuquerque, NM 87110 USA. [Cothern, Kristin] URS Corp, Santa Barbara, CA 93117 USA. [Landers, Cliff] Stetson Engineers Inc, Albuquerque, NM 87120 USA. [Hummel, Ondrea C.] US Army Corps Engineers, Albuquerque, NM 87109 USA. RP Caplan, TR (reprint author), GeoSyst Anal Inc, 3150 Carlisle Blvd,NE,Suite 107, Albuquerque, NM 87110 USA. EM todd@gsanalysis.com NR 38 TC 2 Z9 2 U1 3 U2 37 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD SEP PY 2013 VL 21 IS 5 BP 627 EP 638 DI 10.1111/j.1526-100X.2012.00928.x PG 12 WC Ecology SC Environmental Sciences & Ecology GA 209DN UT WOS:000323734500014 ER PT J AU Burmester, GR Weinblatt, ME McInnes, IB Porter, D Barbarash, O Vatutin, M Szombati, I Esfandiari, E Sleeman, MA Kane, CD Cavet, G Wang, B Godwood, A Magrini, F AF Burmester, Gerd R. Weinblatt, Michael E. McInnes, Iain B. Porter, Duncan Barbarash, Olga Vatutin, Mykola Szombati, Istvan Esfandiari, Ehsanollah Sleeman, Matthew A. Kane, Christopher D. Cavet, Guy Wang, Bing Godwood, Alex Magrini, Fabio TI Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis SO ANNALS OF THE RHEUMATIC DISEASES LA English DT Article DE Rheumatoid Arthritis; Treatment; Disease Activity AB Objectives Mavrilimumab, a human monoclonal antibody targeting the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor, was evaluated in a phase 2 randomised, double-blind, placebo-controlled study to investigate efficacy and safety in subjects with rheumatoid arthritis (RA). Methods Subcutaneous mavrilimumab (10mg, 30mg, 50mg, or 100mg) or placebo was administered every other week for 12weeks in subjects on stable background methotrexate therapy. The primary endpoint was the proportion of subjects achieving a 1.2 decrease from baseline in Disease Activity Score (DAS28-CRP) at week 12. Results 55.7% of mavrilimumab-treated subjects met the primary endpoint versus 34.7% placebo (p=0.003) at week 12; for the 10mg, 30mg, 50mg, and 100mg groups, responses were 41.0% (p=0.543), 61.0% (p=0.011), 53.8% (p=0.071), and 66.7% (p=0.001) respectively. Response rate differences from placebo were observed at week 2 and increased throughout the treatment period. The 100mg dose demonstrated a significant effect versus placebo on DAS28-CRP<2.6 (23.1% vs 6.7%, p=0.016), all categories of the American College of Rheumatology (ACR) criteria (ACR20: 69.2% vs 40.0%, p=0.005; ACR50: 30.8% vs 12.0%, p=0.021; ACR70: 17.9% vs 4.0%, p=0.030), and the Health Assessment Questionnaire Disability Index (-0.48 vs -0.25, p=0.005). A biomarker-based disease activity score showed a dose-dependent decrease at week 12, indicating suppression of disease-related biological pathways. Adverse events were generally mild or moderate in intensity. No significant hypersensitivity reactions, serious or opportunistic infections, or changes in pulmonary parameters were observed. Conclusions Mavrilimumab induced rapid clinically significant responses in RA subjects, suggesting that inhibiting the mononuclear phagocyte pathway may provide a novel therapeutic approach for RA. C1 [Burmester, Gerd R.] Free Univ Berlin, Charite Univ Med, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany. [Burmester, Gerd R.] Humboldt Univ, D-10099 Berlin, Germany. [Weinblatt, Michael E.] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA. [McInnes, Iain B.] Glasgow Biomed Res Ctr, Glasgow, Lanark, Scotland. [Porter, Duncan] Gartnavel Royal Hosp, Dept Rheumatol, Glasgow, Lanark, Scotland. [Barbarash, Olga] SIH Kemerovo Reg Clin Hosp, Kemerovo, Russia. [Vatutin, Mykola] Donetsk Natl Med Univ Named M Gorky, Donestsk, Ukraine. [Szombati, Istvan] Obudai Egeszsegugyi Ctr, Budapest, Hungary. [Esfandiari, Ehsanollah; Sleeman, Matthew A.; Godwood, Alex; Magrini, Fabio] MedImmune Ltd, Cambridge, England. [Kane, Christopher D.] MedImmune LLC, Gaithersburg, MD USA. [Cavet, Guy] Crescendo Biosci Inc, San Francisco, CA USA. [Wang, Bing] MedImmune LLC, Hayward, CA USA. [Esfandiari, Ehsanollah] Univ London Imperial Coll Sci Technol & Med, Div Med Immunol Inflammat, London, England. [Magrini, Fabio] Lilly Biotechnol Ctr, San Diego, CA USA. [Cavet, Guy] Kaggle, San Francisco, CA USA. [Kane, Christopher D.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Burmester, GR (reprint author), Free Univ Berlin, Charite Univ Med, Charitepl 1, D-10117 Berlin, Germany. EM Gerd.Burmester@charite.de OI McInnes, Iain/0000-0002-6462-4280; Porter, Duncan/0000-0001-8481-5204 FU MedImmune Ltd. FX The study was sponsored by MedImmune Ltd. NR 44 TC 61 Z9 63 U1 1 U2 11 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0003-4967 J9 ANN RHEUM DIS JI Ann. Rheum. Dis. PD SEP PY 2013 VL 72 IS 9 BP 1445 EP 1452 DI 10.1136/annrheumdis-2012-202450 PG 8 WC Rheumatology SC Rheumatology GA 201RQ UT WOS:000323161100003 PM 23234647 ER PT J AU Ingram, K Duthaler, U Vargas, M Ellis, W Keiser, J AF Ingram, Katrin Duthaler, Urs Vargas, Mireille Ellis, William Keiser, Jennifer TI Disposition of Mefloquine and Enpiroline Is Highly Influenced by a Chronic Schistosoma mansoni Infection SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PRAZIQUANTEL; MICE; ARTESUNATE; ABSORPTION; EXCRETION; EFFICACY; TRIAL AB Chronic Schistosoma mansoni infections lead to severe tissue destruction of the gut wall and liver and can influence drug disposition. This study aimed to investigate the impact of a chronic S. mansoni infection on the pharmacokinetic (PK) parameters of two promising antischistosomal lead candidates (mefloquine and enpiroline) in mice. Studies were conducted in two different mouse cohorts (S. mansoni-infected and uninfected mice) for both drugs. Plasma samples were collected at various time points after oral treatment (200 mg/kg of body weight) with study drugs. A high-performance liquid chromatography (HPLC) method was validated to analyze enpiroline and mefloquine in plasma. Livers and intestines were collected from infected animals to determine the onset of action, hepatic shift, and worm burden reduction. Following mefloquine administration, hepatic shifting and significant worm burden reductions (79.2%) were observed after 72 h. At 1 week posttreatment with enpiroline, the majority of worms had migrated to the liver and significant worm burden reductions were observed (93.1%). The HPLC method was selective, accurate (87.8 to 111.4%), and precise (<10%) for the analysis of both drugs in plasma samples. The PK profiles revealed increased values for half-life (t(1/2)) and area under the concentration-time curve (AUC) for both drugs in infected animals compared to the t(1/2) and AUC values in uninfected animals. Considerable changes were observed for mefloquine, with a 5-fold increase of t(1/2) (182.7 h versus 33.6 h) and 2-fold increase of AUC (1,116,517.8 ng.h/ml versus 522,409.1 ng.h/ml). S. mansoni infections in mice influence the PK profiles of enpiroline and mefloquine, leading to delayed clearance. Our data confirm that drug disposition should be carefully studied in schistosomiasis patients. C1 [Ingram, Katrin; Duthaler, Urs; Vargas, Mireille; Keiser, Jennifer] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland. [Ingram, Katrin; Duthaler, Urs; Vargas, Mireille; Keiser, Jennifer] Univ Basel, Basel, Switzerland. [Ellis, William] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Chem Informat, Washington, DC 20307 USA. RP Keiser, J (reprint author), Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland. EM jennifer.keiser@unibas.ch OI Duthaler, Urs/0000-0002-7811-3932 FU Swiss National Science Foundation [PPOOA3-114941, PPOOP3_135170]; Scientific & Technological Cooperation Programme Switzerland-Russia FX This work was supported by the Swiss National Science Foundation (project no. PPOOA3-114941 and PPOOP3_135170 to J.K., U. D., and M. V.) and the Scientific & Technological Cooperation Programme Switzerland-Russia (J.K. and K.I.). NR 26 TC 5 Z9 5 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2013 VL 57 IS 9 BP 4506 EP 4511 DI 10.1128/AAC.01129-13 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 203IL UT WOS:000323285500053 PM 23836173 ER PT J AU Bednar, AJ Averett, DE Seiter, JM Lafferty, B Jones, WT Hayes, CA Chappell, MA Clarke, JU Steevens, JA AF Bednar, A. J. Averett, D. E. Seiter, J. M. Lafferty, B. Jones, W. T. Hayes, C. A. Chappell, M. A. Clarke, J. U. Steevens, J. A. TI Characterization of metals released from coal fly ash during dredging at the Kingston ash recovery project SO CHEMOSPHERE LA English DT Article DE Fly ash; Dredging; Speciation; Metal release ID FUEL COMBUSTION RESIDUES; INORGANIC CONSTITUENTS; WATER; MOBILIZATION; ELEMENTS; STANDARD; IMPACTS AB A storage-pond dike failure occurred on December 22, 2008 at the Tennessee Valley Authority Kingston Fossil Plant resulting in the release of over 4 million cubic meters (5 million cubic yards) of fly ash. Approximately half of the released ash was deposited in the main channel of the Emory River, Tennessee, USA. Remediation efforts of the Emory River focused on hydraulic dredging, as well as mechanical excavation in targeted areas. However, agitation of the submerged fly ash during hydraulic dredging introduces river water into the fly ash material, which could promote dissolution and desorption of metals from the solid fly ash material. Furthermore, aeration of the dredge slurry could alter the redox state of metals in the fly ash material and thereby change their sorption, mobility, and toxicity properties. The research presented here focuses on the concentrations and speciation of metals during the fly ash recovery from the Emory River. Our results indicate that arsenite [As(III)] released from the fly ash material during dredging was slowly oxidized to arsenate [As(V)] in the slurry recovery system with subsequent removal through precipitation or sorption reactions with suspended fly ash material. Concentrations of other dissolved metals, including iron and manganese, also generally decreased in the ash recovery system prior to water discharge back to the river. Published by Elsevier Ltd. C1 [Bednar, A. J.; Averett, D. E.; Seiter, J. M.; Lafferty, B.; Jones, W. T.; Hayes, C. A.; Chappell, M. A.; Clarke, J. U.; Steevens, J. A.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil NR 27 TC 3 Z9 3 U1 2 U2 36 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD SEP PY 2013 VL 92 IS 11 BP 1563 EP 1570 DI 10.1016/j.chemosphere.2013.04.034 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 203MR UT WOS:000323297800023 PM 23706374 ER PT J AU Choi, KK Jhabvala, MD Forrai, DP Waczynski, A Sun, J Jones, R AF Choi, Kwong-Kit Jhabvala, Murzy D. Forrai, David P. Waczynski, Augustyn Sun, Jason Jones, Robert TI Electromagnetic Modeling and Design of Quantum Well Infrared Photodetectors SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE Electromagnetic field modeling; infrared detector; quantum efficiency (QE) AB The quantum efficiency (QE) of a quantum well infrared photodetector (QWIP) is historically difficult to predict and optimize. This difficulty is due to the lack of a quantitative model to calculate QE for a given detector structure. In this paper, we found that by expressing QE in terms of a volumetric integral of the vertical electric field, the QE can be readily evaluated using a finite element electromagnetic solver. We applied this model to all known QWIP structures in the literature and found good agreement with experiment in all cases. Furthermore, the model agrees with other theoretical solutions, such as the classical solution and the modal transmission-line solution when they are available. Therefore, we have established the validity of this model, and it can now be used to design new detector structures with the potential to greatly improve the detector QE. C1 [Choi, Kwong-Kit; Sun, Jason] US Army Res Lab, Adelphi, MD 20833 USA. [Jhabvala, Murzy D.; Waczynski, Augustyn] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Forrai, David P.; Jones, Robert] L 3 Cincinnati Elect, Mason, OH 45040 USA. RP Choi, KK (reprint author), US Army Res Lab, Adelphi, MD 20833 USA. EM kwong.k.choi.civ@mail.mil; Murzy.D.Jhabvala@nasa.gov; Dave.Forrai@L-3Com.com; augustyn.waczynski-1@nasa.gov; guifu.n.sun.civ@mail.mil; Robert.Jones@L-3Com.com RI Choi, Kwong-Kit/K-9205-2013 NR 19 TC 3 Z9 5 U1 0 U2 25 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD SEP-OCT PY 2013 VL 19 IS 5 DI 10.1109/JSTQE.2012.2216861 PG 10 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 202JM UT WOS:000323210900029 ER PT J AU Tekleab, AG Orvis, KA Taylor, MS AF Tekleab, Amanuel G. Orvis, Karin A. Taylor, M. Susan TI Deleterious Consequences of Change in Newcomers' Employer-Based Psychological Contract Obligations SO JOURNAL OF BUSINESS AND PSYCHOLOGY LA English DT Article DE Psychological contract change; Breach; Newcomers; Latent growth curve modeling ID ORGANIZATIONAL CITIZENSHIP BEHAVIOR; SOCIAL-EXCHANGE; SOCIALIZATION; BREACH; SATISFACTION; TIME; PERFORMANCE; VIOLATIONS; VELOCITY; IMPACT AB This study examines the issue of change in newcomers' employer-based psychological contract obligations over time, viewing change as a potentially important determinant of perceived contract breach and subsequent employee attitudes and behaviors. Data were collected using a three-wave longitudinal design from newly hired faculty members (N = 106). Newcomers' perceptions of employer-based relational obligations significantly decreased during their first year on the job. Newcomers reacted negatively to these changes, subsequently reporting increased contract breach and more negative work attitudes (i.e., increased turnover intentions and reduced job satisfaction and organizational loyalty). This study provides evidence of the negative effects of perceived changes to a newcomer's psychological contract. Practitioners should implement interventions to ensure a realistic set of psychological contract obligations are developed from the start in order to minimize the likelihood that newcomers will modify these obligations downward; and, therefore, experience these negative attitudes toward the organization. Drawing from the realistic job preview and socialization literatures, this study examines a topic that has received little empirical attention in the extant psychological contract research, yet has important implications to the management of employees' psychological contracts. Using both a three-wave longitudinal field design and a more rigorous statistical analysis for assessing change (i.e., latent growth curve modeling), we add a unique contribution to the extant research by identifying the negative consequences of psychological contract change on newcomers' subsequent work perceptions and attitudes. C1 [Tekleab, Amanuel G.] Wayne State Univ, Sch Business Adm, Detroit, MI 48202 USA. [Orvis, Karin A.] US Army, Foundat Sci Res Unit, Res Inst Behav & Social Sci, Ft Belvoir, VA 22060 USA. [Taylor, M. Susan] Univ Maryland, Robert H Smith Sch Business, College Pk, MD 20742 USA. RP Tekleab, AG (reprint author), Wayne State Univ, Sch Business Adm, Detroit, MI 48202 USA. EM atekleab@wayne.edu; karin.orvis@gmail.com; staylor@rhsmith.umd.edu NR 61 TC 5 Z9 6 U1 5 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0889-3268 J9 J BUS PSYCHOL JI J. Bus. Psychol. PD SEP PY 2013 VL 28 IS 3 BP 361 EP 374 DI 10.1007/s10869-012-9277-2 PG 14 WC Business; Psychology, Applied SC Business & Economics; Psychology GA 202GS UT WOS:000323202700008 ER PT J AU Vincenti, MA de Ceglia, D Grande, M D'Orazio, A Scalora, M AF Vincenti, M. A. de Ceglia, D. Grande, M. D'Orazio, A. Scalora, M. TI Tailoring Absorption in Metal Gratings with Resonant Ultrathin Bridges SO PLASMONICS LA English DT Article DE Surface plasmons; Gratings; Optical absorption ID SURFACE-PLASMONS; HOLE ARRAYS; 2ND-HARMONIC GENERATION; ENHANCED TRANSMISSION; OPTICAL-TRANSMISSION; THIN-FILMS; LIGHT; GAAS; SLIT; NANOPARTICLES AB We present a theoretical analysis of the effects of short range surface plasmon polariton excitation on subwavelength bridges in metal gratings. We show that localized resonances in thin metal bridges placed within the slit of a free-standing silver grating dramatically modify transmission spectra and boost absorption regardless of the periodicity of the grating. Additionally, the interference of multiple localized resonances makes it possible to tailor the absorption properties of ultrathin gratings, regardless of the apertures' geometrical size. This tunable, narrow band, enhanced-absorption mechanism triggered by resonant, short-range surface plasmon polaritons may also enhance nonlinear optical processes like harmonic generation, in view of the large third-order susceptibility of metals. C1 [Vincenti, M. A.; de Ceglia, D.] CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Grande, M.; D'Orazio, A.] Politecn Bari, DIEI, I-70126 Bari, Italy. [Scalora, M.] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM maria.vincenti@us.army.mil RI Petruzzelli, Vincenzo/H-5188-2012 OI Petruzzelli, Vincenzo/0000-0001-6921-9981 FU National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center; U.S. Army International Technology Center Atlantic [W911NF-12-1-0292] FX This research was performed while the authors M. A. Vincenti and D. de Ceglia held a National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center. M. Grande thanks the U.S. Army International Technology Center Atlantic for financial support (contract no. W911NF-12-1-0292). The authors also thank F. Dioguardi for helpful discussions. NR 68 TC 4 Z9 4 U1 0 U2 22 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1955 EI 1557-1963 J9 PLASMONICS JI Plasmonics PD SEP PY 2013 VL 8 IS 3 BP 1445 EP 1456 DI 10.1007/s11468-013-9558-2 PG 12 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 203FL UT WOS:000323276500018 ER PT J AU Guda, T Walker, JA Singleton, BM Hernandez, JW Son, JS Kim, SG Oh, DS Appleford, MR Ong, JL Wenke, JC AF Guda, Teja Walker, John A. Singleton, Brian M. Hernandez, Jesus W. Son, Jun-Sik Kim, Su-Gwan Oh, Daniel S. Appleford, Mark R. Ong, Joo L. Wenke, Joseph C. TI Guided Bone Regeneration in Long-Bone Defects with a Structural Hydroxyapatite Graft and Collagen Membrane SO TISSUE ENGINEERING PART A LA English DT Article ID BARRIER MEMBRANES; IN-VIVO; RABBITS; DOGS; SCAFFOLDS; MODEL; TIBIA AB There are few synthetic graft alternatives to treat large long-bone defects resulting from trauma or disease that do not incorporate osteogenic or osteoinductive factors. The aim of this study was to test the additional benefit of including a permeable collagen membrane guide in conjunction with a preformed porous hydroxyapatite bone graft to serve as an improved osteoconductive scaffold for bone regeneration. A 10-mm-segmental long-bone defect model in the rabbit radius was used. The hydroxyapatite scaffolds alone or with a collagen wrap were compared as experimental treatment groups to an empty untreated defect as a negative control or a defect filled with autologous bone grafts as a positive control. All groups were evaluated after 4 and 8 weeks of in vivo implantation using microcomputed tomography, mechanical testing in flexure, and histomorphometry. It was observed that the use of the wrap resulted in an increased bone volume regenerated when compared to the scaffold-only group (59% greater at 4 weeks and 27% greater after 8 weeks). Additionally, the increase in density of the regenerated bone from 4 to 8 weeks in the wrap group was threefold than that in the scaffold group. The use of the collagen wrap showed significant benefits of increased interfacial bone in-growth (149% greater) and periosteal remodeling (49%) after 4 weeks compared to the scaffold-alone with the two groups being comparable after 8 weeks, by when the collagen membrane showed close-to-complete resorption. While the autograft and wrap groups showed significantly greater flexural strength than the defect group after 8 weeks, the scaffold-alone group was not significantly different from the other three groups. It is most likely that the wrap shows improvement of function by acting like a scaffold for periosteal callus ossification, maintaining the local bone-healing environment while reducing fibrous infiltration (15% less than scaffold only at 4 weeks). This study indicates that the use of a collagen membrane with a hydroxyapatite structural graft provides benefits for bone tissue regeneration in terms of early interfacial integration. C1 [Guda, Teja; Walker, John A.; Wenke, Joseph C.] US Army, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, Ft Sam Houston, TX USA. [Guda, Teja; Singleton, Brian M.; Hernandez, Jesus W.; Appleford, Mark R.; Ong, Joo L.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. [Son, Jun-Sik; Kim, Su-Gwan] Chosun Univ, Coll Dent, Kwangju, South Korea. [Son, Jun-Sik; Kim, Su-Gwan] Kyungpook Natl Univ, Inst Biomat Res & Dev, Taegu, South Korea. [Oh, Daniel S.] Columbia Univ, Med Ctr, Dept Orthopaed Surg, New York, NY USA. RP Guda, T (reprint author), Univ Texas San Antonio, Dept Biomed Engn, 1 UTSA Circle, San Antonio, TX 78249 USA. EM teja.guda@gmail.com OI Guda, Teja/0000-0002-3218-2916 FU Department of Defense funds; Orthopaedic Extremity Trauma Research Program [W81XWH-08-1-0393, W81XWH-07-1-0717] FX This study was supported in part by the Department of Defense funds and the Orthopaedic Extremity Trauma Research Program grants (USAMRMC # W81XWH-08-1-0393 and W81XWH-07-1-0717). The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. This study has been conducted in compliance with the Animal Welfare Act, the implementing Animal Welfare Regulations, and in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. NR 27 TC 7 Z9 7 U1 1 U2 24 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD SEP PY 2013 VL 19 IS 17-18 BP 1879 EP 1888 DI 10.1089/ten.tea.2012.0057 PG 10 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 190ES UT WOS:000322322600001 PM 22844877 ER PT J AU Coleman, JG Kennedy, AJ Bednar, AJ Ranville, JF Laird, JG Harmon, AR Hayes, CA Gray, EP Higgins, CP Lotufo, G Steevens, JA AF Coleman, Jessica G. Kennedy, Alan J. Bednar, Anthony J. Ranville, James F. Laird, Jennifer G. Harmon, Ashley R. Hayes, Charolett A. Gray, Evan P. Higgins, Christopher P. Lotufo, Guilherme Steevens, Jeffery A. TI Comparing the effects of nanosilver size and coating variations on bioavailability, internalization, and elimination, using Lumbriculus variegatus SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nanoparticles; Silver; Aquatic; Lumbriculus variegatus; Bioavailability ID SILVER NANOPARTICLES; TOXICITY; NANOMATERIALS; ENVIRONMENT; BIOACCUMULATION; ORGANISMS; TRANSPORT; SEDIMENTS; RELEASE AB As the production and applications of silver nanoparticles (AgNPs) increase, it is essential to characterize fate and effects in environmental systems. Nanosilver materials may settle from suspension; therefore, the authors' objective was to utilize environmentally relevant bioassays and study the impact, bioaccumulation, tissue distribution, uptake, and depuration of AgNPs on a sediment-dwelling invertebrate, Lumbriculus variegatus. Hydrodynamic diameters of uncoated 30-nm, 80-nm, and 1500-nm AgNP powders and a polyvinyl pyrrolidone (PVP) AgNP suspension were measured utilizing dynamic light scattering in freshwater media (0-280 mu S/cm). Aggregation for 30 nm, 80 nm, and 1500 nm silver increased with conductivity but was minimal for PVP silver. Lumbriculus variegatus were exposed to AgNPs or silver nitrate (AgNO3) spiked into sediment (nominally 100 mg/kg) and water (PVP 30 nm and 70 nm Ag, nominally 5 mg/L). Uptake was assessed through inductively coupled plasma mass spectroscopy (ICP-MS) and hyperspectral imaging. Particle sizes were examined through field flow fractionation-ICP-MS (FFF-ICP-MS) and ICP-MS in single particle mode (SP-ICP-MS). Lumbriculus variegatus were also depurated for 6 h, 8 h, 24 h, and 48 h to determine gut clearance. Bioaccumulation factors of sediment-exposed L. variegatus were similar regardless of particle size or coatings. The FFF-ICP-MS and SP-ICP-MS detected AgNPs for up to 48 h post depuration. The present study provides information on bioaccumulation and interactions of AgNPs within biological systems. (C) 2013 SETAC C1 [Coleman, Jessica G.; Kennedy, Alan J.; Bednar, Anthony J.; Laird, Jennifer G.; Harmon, Ashley R.; Lotufo, Guilherme; Steevens, Jeffery A.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Ranville, James F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Hayes, Charolett A.] Spec Pro, Vicksburg, MS USA. [Gray, Evan P.; Higgins, Christopher P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. RP Coleman, JG (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM jessica.g.coleman@us.army.mil RI Higgins, Christopher/B-1836-2010; OI Higgins, Christopher/0000-0001-6220-8673; ranville, james/0000-0002-4347-4885 NR 31 TC 27 Z9 27 U1 3 U2 121 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD SEP PY 2013 VL 32 IS 9 BP 2069 EP 2077 DI 10.1002/etc.2278 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 189FX UT WOS:000322253800018 PM 23686570 ER PT J AU Yan, T Li, QZ Li, YZ Li, ZH Zheng, G AF Yan, Ting Li, Qizhai Li, Yuanzhang Li, Zhaohai Zheng, Gang TI Genetic Association With Multiple Traits in the Presence of Population Stratification SO GENETIC EPIDEMIOLOGY LA English DT Article DE inverted regression; genomic control; MultiPhen; pleiotropy; proportional odds model; population structure; principal component analysis; variance inflation factor ID GENOME-WIDE ASSOCIATION; PRINCIPAL-COMPONENTS; QUANTITATIVE TRAITS; RARE VARIANTS; SUBSTRUCTURE; BINARY; TESTS; POWER; MODEL AB Testing association between a genetic marker and multiple-dependent traits is a challenging task when both binary and quantitative traits are involved. The inverted regression model is a convenient method, in which the traits are treated as predictors although the genetic marker is an ordinal response. It is known that population stratification (PS) often affects population-based association studies. However, how it would affect the inverted regression for pleiotropic association, especially with the mixed types of traits (binary and quantitative), is not examined and the performance of existing methods to correct for PS using the inverted regression analysis is unknown. In this paper, we focus on the methods based on genomic control and principal component analysis, and investigate type I error of pleiotropic association using the inverted regression model in the presence of PS with allele frequencies and the distributions (or disease prevalences) of multiple traits varying across the subpopulations. We focus on common alleles but simulation results for a rare variant are also reported. An application to the HapMap data is used for illustration. C1 [Yan, Ting] Cent China Normal Univ, Wuhan, Peoples R China. [Yan, Ting; Li, Zhaohai] George Washington Univ, Washington, DC USA. [Yan, Ting] Digital Syst Inc, Chevy Chase, MD USA. [Li, Qizhai] Chinese Acad Sci, Beijing, Peoples R China. [Li, Yuanzhang] Walter Reed Army Inst Res, Silver Spring, MD USA. [Zheng, Gang] NHLBI, Bethesda, MD 20892 USA. RP Zheng, G (reprint author), NHLBI, Off Biostat Res, 6701 Rockledge Dr, Bethesda, MD 20892 USA. EM zhengg@nhlbi.nih.gov OI Li, Yuanzhang/0000-0001-8872-4430 FU Department of the Army In-House Laboratory Independent Research [W81XWH-11-C-0082]; Small Business Innovation Research [W81XWH11C0511] FX The part of effort (authors from GWU and WRAIR) is funded by Department of the Army In-House Laboratory Independent Research W81XWH-11-C-0082 and the Small Business Innovation Research W81XWH11C0511. The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army, Department of Defense, or National Institutes of Health. None of the authors have any associations, financial or otherwise, that may present a conflict of interest. The authors thank Paul O'Reilly for the thoughtful comments and suggestions. NR 29 TC 7 Z9 7 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0741-0395 J9 GENET EPIDEMIOL JI Genet. Epidemiol. PD SEP PY 2013 VL 37 IS 6 BP 571 EP 580 DI 10.1002/gepi.21738 PG 10 WC Genetics & Heredity; Mathematical & Computational Biology SC Genetics & Heredity; Mathematical & Computational Biology GA 198GT UT WOS:000322911100005 PM 23740720 ER PT J AU Ji, MK Abou-Shanab, RAI Hwang, JH Timmes, TC Kim, HC Oh, YK Jeon, BH AF Ji, Min-Kyu Abou-Shanab, Reda A. I. Hwang, Jae-Hoon Timmes, Thomas C. Kim, Hyun-Chul Oh, You-Kwan Jeon, Byong-Hun TI Removal of Nitrogen and Phosphorus from Piggery Wastewater Effluent Using the Green Microalga Scenedesmus obliquus SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Article DE Piggery wastewater effluent; Scenedesmus obliquus; Microalga; Nutrient removal; Lipid productivity; Biofuel ID BIODIESEL PRODUCTION; STRUVITE PRECIPITATION; NUTRIENT REMOVAL; CHLORELLA-VULGARIS; BIOFUEL PRODUCTION; LIPID PRODUCTION; PIG MANURE; GROWTH; ALGAE; CULTIVATION AB Piggery effluent is one of the most highly produced wastewaters throughout the world, containing high levels of inorganic nutrient species. In this study, a microalga Scenedesmus obliquus YSW-14 (S. obliquus) was employed not only for nutrient removal from piggery wastewater effluent but also for lipid accumulation in the algal biomass as a feedstock for biofuel production. The piggery wastewater effluent was diluted up to fivefold with synthetic media to reduce the toxicity of (in)organic components, which resulted in improved microalgal growth, nutrient removal, and lipid productivity. Among the examined culture conditions, a 40% concentration of wastewater effluent was found to be most effective for microalga lipid productivity (). S. obliquus removed 155mg total nitrogen and 4mg total phosphate per gram of dried algae for growth at the same dilution condition. These results demonstrate the feasibility of using microalgae for advanced wastewater treatment and subsequent production of lipids as biofuel feedstock. C1 [Ji, Min-Kyu; Hwang, Jae-Hoon; Jeon, Byong-Hun] Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea. [Abou-Shanab, Reda A. I.] City Sci Res & Technol Applicat, Dept Environm Biotechnol, Alexandria 21934, Egypt. [Timmes, Thomas C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Kim, Hyun-Chul] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. [Oh, You-Kwan] Korea Inst Energy Res, Bioenergy Res Ctr, Taejon 305343, South Korea. RP Jeon, BH (reprint author), Yonsei Univ, Dept Environm Engn, Wonju 220710, South Korea. EM bhjeon@yonsei.ac.kr RI City for Scientific , and Research/E-6802-2017; OI Jeon, Byong-Hun/0000-0002-5478-765X; Abou-Shanab, Reda/0000-0002-3338-8094 FU Korea Institute of Energy Research; Senior Researchers program (the National Research Foundation of Korea) [2010-0026904]; Global Research Laboratory Project (Ministry of Education, Science and Technology) [B030305]; Eco-Innovation project (Global-Top project) of the Korea Ministry of Environment [2012001090001] FX This work was supported by the Korea Institute of Energy Research, the Senior Researchers program (the National Research Foundation of Korea, 2010-0026904), the Global Research Laboratory Project (Ministry of Education, Science and Technology, B030305) and the Eco-Innovation project (Global-Top project, 2012001090001) of the Korea Ministry of Environment. NR 71 TC 15 Z9 15 U1 4 U2 97 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD SEP 1 PY 2013 VL 139 IS 9 BP 1198 EP 1205 DI 10.1061/(ASCE)EE.1943-7870.0000726 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 198YY UT WOS:000322961500007 ER PT J AU Houston, JR AF Houston, James R. TI Methodology for Combining Coastal Design-Flood Levels and Sea-Level Rise Projections SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Sea level; Floods; Coastal structures; Structural design; Sea-level rise; Coastal flooding; Storm surge AB Design-flood levels with associated exceedance probabilities are usually determined for coastal flood protection projects. Rising sea level introduces another design feature that needs to be combined with the design-flood level. However, most sea-level projections do not have exceedance probabilities that can be used in conjunction with the design flood to obtain total flood levels. This paper shows how to combine design-flood levels with sea-level rise projections that have exceedance probabilities, such as those of the Intergovernmental Panel for Climate Change, to obtain total elevations at desired exceedance probabilities over particular intervals. (C) 2013 American Society of Civil Engineers. C1 USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Houston, JR (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 14 TC 1 Z9 1 U1 0 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C JI J. Waterw. Port Coast. Ocean Eng. PD SEP 1 PY 2013 VL 139 IS 5 BP 341 EP 345 DI 10.1061/(ASCE)WW.1943-5460.0000194 PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 201RN UT WOS:000323160800001 ER PT J AU Wall, WA Hohmann, MG Walker, AS Gray, JB AF Wall, Wade A. Hohmann, Matthew G. Walker, Andrew S. Gray, Janet B. TI Sex ratios and population persistence in the rare shrub Lindera subcoriacea Wofford SO PLANT ECOLOGY LA English DT Article DE Lindera subcoriacea; Sex ratio; Dioecy; Spatial segregation; Small population; Longleaf pine ID DIOECIOUS SHRUB; BENZOIN LAURACEAE; SPATIAL-DISTRIBUTION; ILEX-AQUIFOLIUM; LAUREL WILT; PLANTS; REPRODUCTION; SIZE; EXTINCTION; REVISITATION AB Biased sex ratios can have conservation consequences for dioecious plant species with small population sizes because of an increased risk of single sex populations. Biased sex ratios have been observed in two of the three species of Lindera (Lauraceae) in the eastern United States, but have not been documented for Lindera subcoriacea, a rare shrub of the southeastern USA. We inventoried 78 of 118 populations in North Carolina over a 3 year period, documenting the location, community type, and sex, of 299 individuals. In addition, we measured the stem height and diameter for 245 individuals. We examined population persistence relative to historical population size estimates. Average population size was 7.9 individuals and 72 % of visited populations were extant. There was a significant positive correlation between historical estimates of population size and persistence. Lindera subcoriacea consistently had male-biased (58 %) sex ratios across all population sizes and vegetation communities. Males and females had similar stem heights (mean 200.4 vs. 187.8 cm, respectively) and diameters (1.3 vs. 1.2 cm, respectively) across years and were not spatially segregated within populations. It is unclear at what stage biased sex ratios arise in L. subcoriacea, but results suggest that the causes operate across vegetation communities and population sizes. The weak bias exhibited in L. subcoriacea sex ratios has limited implications for the species' conservation except where spatially isolated populations are unisexual. Given the vulnerability of small L. subcoriacea populations to extirpation, they should be high priority targets for management. C1 [Wall, Wade A.; Hohmann, Matthew G.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Walker, Andrew S.] Walker Bot Consulting, Southern Pines, NC 28387 USA. [Gray, Janet B.] Endangered Species Branch, Ft Bragg, NC 28310 USA. RP Wall, WA (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM wade.a.wall@usace.army.mil; matthew.g.hohmann@usace.army.mil; walker.botanical@gmail.com; janet.b.gray.civ@mail.mil FU US Army via the ERDC Environmental Quality and Installations business area FX The authors thank Fort Bragg Military Reservation and the Endangered Species Brach for permission to perform the study and logistic support. We also thank the North Carolina Natural Heritage Program for information on Lindera subcoriacea populations, Brady Beck (North Carolina Wildlife Resources Commission) for site identification and data collection, and two anonymous reviewers for thoughtful comments that improved the final manuscript. Funding was provided by the US Army via the ERDC Environmental Quality and Installations business area. NR 57 TC 0 Z9 0 U1 2 U2 27 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1385-0237 J9 PLANT ECOL JI Plant Ecol. PD SEP PY 2013 VL 214 IS 9 BP 1105 EP 1114 DI 10.1007/s11258-013-0234-6 PG 10 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA 197XP UT WOS:000322886300002 ER PT J AU Jaqua, NT Stratton, A Yaccobe, L Tahir, U Kenny, P Kerns, T AF Jaqua, Nathan T. Stratton, Amy Yaccobe, Lior Tahir, Usman Kenny, Patrick Kerns, Tamie TI A review of the literature on three extraintestinal complications of ulcerative colitis : an ulcerative colitis flare complicated by Budd-Chiari syndrome, cerebral venous thrombosis and idiopathic thrombocytopenia SO ACTA GASTRO-ENTEROLOGICA BELGICA LA English DT Review DE ulcerative colitis; idiopathic thrombocytopenia; ITP; Budd-Chiari syndrome; BCS; cerebral venous thrombosis; CVT; extraintestinal complications; complications ID INFLAMMATORY-BOWEL-DISEASE; SAGITTAL SINUS THROMBOSIS; HEPATIC VEIN-THROMBOSIS; IMMUNE THROMBOCYTOPENIA; VASCULAR COMPLICATIONS; PURPURA; THROMBOLYSIS; COLECTOMY; HEPARIN; COAGULATION AB Extraintestinal manifestations are well described and recognized in association with ulcerative colitis. Immunologically mediated and thrombotic events are among the more rare manifestations associated with flares. These manifestations include Budd-Chiari syndrome, idiopathic thrombocytopenia, and cerebral venous thrombosis. A 22 year-old male with a three-year history of ulcerative colitis presented with worsening hematochezia, fatigue, headache and upper respiratory symptoms. Laboratory evaluation demonstrated a platelet count of 24 x 10(9)/L (normal baseline platelet count noted 3 months prior) and hemoglobin of 8.6 x 10(9)/L. Imaging demonstrated hepatic venous thrombosis consistent with Budd-Chiari syndrome and cerebral venous thrombosis. Based on peripheral smear analysis and eventual marked response to steroids, a diagnosis of idiopathic thrombocytopenia was made. He was started on prednisone 40mg daily with brisk improvement in both his ulcerative colitis flare and his platelet count increasing above 100 x 10(9)/L. He was therapeutically anticoagulated for the cerebral venous thrombosis. He continued to do well and was discharged on therapeutic enoxaparin and a 40 mg prednisone taper without recurrent flare or idiopathic thrombocytopenia two weeks post-hospitalization. To our knowledge, this is the first report of all three known but rare complications diagnosed concurrently in the same patient. This review examines three extraintestinal complications of ulcerative colitis, including the presentation, diagnosis, and treatment. C1 [Jaqua, Nathan T.; Stratton, Amy; Yaccobe, Lior; Tahir, Usman; Kenny, Patrick; Kerns, Tamie] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Kenny, Patrick] Tripler Army Med Ctr, Gastroenterol Serv, Honolulu, HI 96859 USA. [Kerns, Tamie] Tripler Army Med Ctr, Hematol & Oncol Serv, Honolulu, HI 96859 USA. RP Jaqua, NT (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM nathan.jaqua@gmail.com NR 53 TC 0 Z9 1 U1 0 U2 0 PU UNIV CATHOLIQUE LOUVAIN-UCL PI BRUSSELS PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM SN 0001-5644 EI 1477-4607 J9 ACTA GASTRO-ENT BELG JI Acta Gastro-Enterol. Belg. PD SEP PY 2013 VL 76 IS 3 BP 311 EP 316 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AO5JO UT WOS:000341380900006 PM 24261025 ER PT J AU Li, XN Ma, R Nielsen, NM Gulotta, LV Dines, JS Owens, BD AF Li, Xinning Ma, Richard Nielsen, Natalie M. Gulotta, Lawrence V. Dines, Joshua S. Owens, Brett D. TI Management of Shoulder Instability in the Skeletally Immature Patient SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review AB Several studies have focused on management of shoulder instability in the adolescent and young adult population. However, a paucity of literature exists regarding shoulder dislocation in the skeletally immature population. The presence of an open physis makes the dislocated pediatric shoulder a challenging clinical problem. In general, management includes prompt reduction and sling immobilization. In athletic patients aged >= 14 years with a Bankart lesion, early surgical intervention may be warranted because of the higher risk of recurrent instability. However, the literature on younger skeletally immature patients is less clear in terms of risk of further instability and the necessity of surgical intervention. In the skeletally immature population, a relatively low rate of recurrent instability after primary dislocation has been reported in the recent literature. Surgical intervention should be considered for patients with recurrent instability. C1 [Li, Xinning] Boston Univ, Sch Med, Dept Orthopaed Surg, Div Sports Med & Shoulder & Elbow Surg, Boston, MA 02118 USA. [Ma, Richard] Univ Missouri, Sch Med, Missouri Orthopaed Inst, Div Sports Med, Columbia, MO USA. [Nielsen, Natalie M.] Univ Massachusetts, Med Ctr, Dept Orthopaed Surg, Worcester, MA USA. [Gulotta, Lawrence V.; Dines, Joshua S.] Hosp Special Surg, Sports Med & Shoulder Surg Serv, Great Neck, NY USA. [Owens, Brett D.] Keller Army Community Hosp, West Point, NY USA. RP Li, XN (reprint author), Boston Univ, Sch Med, Dept Orthopaed Surg, Div Sports Med & Shoulder & Elbow Surg, Boston, MA 02118 USA. NR 41 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1067-151X EI 1940-5480 J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD SEP PY 2013 VL 21 IS 9 BP 529 EP 537 DI 10.5435/JAAOS-21-09-529 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA V37MZ UT WOS:000209281200004 PM 23996984 ER PT J AU Yackel, EE Short, NM Lewis, PC Breckenridge-Sproat, ST Turner, BS AF Yackel, Edward E. Short, Nancy M. Lewis, Paul C. Breckenridge-Sproat, Sara T. Turner, Barbara S. TI Improving the Adoption of Evidence-Based Practice Among Nurses in Army Outpatient Medical Treatment Facilities SO MILITARY MEDICINE LA English DT Article ID IMPLEMENTATION; CULTURE; STRATEGIES; BELIEFS AB This quality improvement project implemented and evaluated an evidence-based practice (EBP) program at two Army outpatient health care facilities. The EBP program consisted of five implementation strategies that aimed to inculcate EBP into organizational culture as well as nursing practice and culture. A conceptual model of the "Diffusion of Innovations" theory was adapted to explain the application of the program. The Institutional Review Boards at Walter Reed National Military Medical Center and Duke University School of Medicine reviewed and exempted this quality improvement project. A pretest-posttest design was used with four instruments at each facility. The EBP program was successful in enhancing organizational culture and readiness for EBP (p < 0.01) and nursing staff's belief about the value of EBP and their ability to implement it (p < 0.05). Another indicator that the EBP program achieved its goals was the significant difference (p = 0.002) in the movement of the outpatient health care facilities toward an EBP culture. These results suggest that this EBP program may be an effective method for empowering outpatient nursing staff with the knowledge and tools necessary to use evidence-based nursing practice. C1 [Yackel, Edward E.] San Antonio Mil Hlth Syst, Dept Clin Operat, San Antonio, TX 78234 USA. [Short, Nancy M.; Turner, Barbara S.] Duke Univ, Sch Nursing, DUMC 3322, Durham, NC 27710 USA. [Lewis, Paul C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Breckenridge-Sproat, Sara T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Yackel, EE (reprint author), San Antonio Mil Hlth Syst, Dept Clin Operat, 7800 I-10 West, San Antonio, TX 78234 USA. FU McDonald Army Health Center, Fort Eustis, Virginia; Kenner Army Health Clinic, Fort Lee, Virginia FX We thank Julie A. Thompson, Duke University School of Nursing, for her expertise in statistical analysis. This quality improvement project was fiscally supported by the leadership of McDonald Army Health Center, Fort Eustis, Virginia and Kenner Army Health Clinic, Fort Lee, Virginia. NR 16 TC 0 Z9 0 U1 2 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2013 VL 178 IS 9 BP 1002 EP 1009 DI 10.7205/MILMED-D-13-00191 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UC UT WOS:000340805500017 PM 24005550 ER PT J AU Belmont, PJ Hoffmann, JD Tokish, JM Arrington, ED Shawen, SB Orr, JD AF Belmont, Philip J., Jr. Hoffmann, Jeffrey D. Tokish, John M. Arrington, Edward D. Shawen, Scott B. Orr, Justin D. TI Overview of the Military Orthopaedic Surgery Residency Application and Selection Process SO MILITARY MEDICINE LA English DT Article ID USMLE STEP 1; PERFORMANCE; RECOMMENDATION; PREDICTORS; DIRECTORS; CRITERIA AB The military offers eight Accreditation Council for Graduate Medical Education-accredited orthopaedic surgery programs with 33 total positions. The Army has 19 orthopedic surgery residency positions and averaged 1.47 applicants per position from 2007 to 2011. Applicants most commonly become eligible for military orthopaedic surgery residency through attendance of the Uniformed Services University of the Health Sciences or participation in the Health Professions Scholarship Program. The Military Operational Data System begins registration on July 1st of the preceding year and is used to match all applicants. The ranking and selection of applicants from medical school is based 50% upon objective criteria regarding the applicant's medical school performance and 50% on the applicant's potential for successful practice as an orthopaedic surgeon. Medical school performance data examined include medical school transcript, Dean's letter, and United States Medical Licensing Examination steps I and II/Comprehensive Osteopathic Medical Licensing Examination of the United Sates I and II scores. Determination of an applicant's potential is based upon letters of recommendation, personal interviews, and most importantly the applicant's performance on military orthopaedic surgery clinical clerkships. Applicants who have completed an internship are similarly scored with points awarded for internship and operational tour performance. C1 [Belmont, Philip J., Jr.; Hoffmann, Jeffrey D.; Orr, Justin D.] Texas Tech Univ, Hlth Sci Ctr, William Beaumont Army Med Ctr, Dept Orthopaed & Rehabil, El Paso, TX 79920 USA. [Tokish, John M.] Tripler Army Med Ctr, Dept Orthopaed & Rehabil, Honolulu, HI 96819 USA. [Arrington, Edward D.] Madigan Army Med Ctr, Joint Base Lewis McChord, Orthopaed Surg Serv, Tacoma, WA 98431 USA. [Shawen, Scott B.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. RP Belmont, PJ (reprint author), Texas Tech Univ, Hlth Sci Ctr, William Beaumont Army Med Ctr, Dept Orthopaed & Rehabil, 5005 North Piedras St, El Paso, TX 79920 USA. OI Belmont, Philip/0000-0003-2618-199X NR 24 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2013 VL 178 IS 9 BP 1016 EP 1023 DI 10.7205/MILMED-D-13-00121 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UC UT WOS:000340805500019 PM 24005552 ER PT J AU Krakauer, T Buckley, M AF Krakauer, Teresa Buckley, Marilyn TI Efficacy of Two FDA-Approved Drug Combination in a Mouse Model of Staphylococcal Enterotoxin B-Induced Shock SO MILITARY MEDICINE LA English DT Article ID TOXIC-SHOCK; BACTERIAL SUPERANTIGENS; N-ACETYLCYSTEINE; SEPTIC SHOCK; LUNG INJURY; INFLAMMATION; INDUCTION; THERAPY; POTENCY; WEAPONS AB Staphylococcal enterotoxin B (SEB) causes lethal shock by potently stimulating the host immune response. Dexamethasone and N-acetyl cysteine (NAC) are anti-inflammatory and antioxidative drugs, respectively, which can independently modulate immune function. Dexamethasone was previously shown to be effective in preventing SEB-induced shock models only if administered early and in multiple doses for a long duration. In this study, dexamethasone and NAC were used in tandem and protected mice (75%) against SEB-induced lethal shock. Hypothermia and weight loss elicited by SEB were also diminished by this novel combination treatment. The levels of monocyte chemoattractant protein-1, interleuldn-2, interleukin-6, and mouse gamma interferon in lung tissue after intranasal exposure to SEB were also significantly reduced in mice given a combination of dexamethasone and NAC versus controls. C1 [Krakauer, Teresa; Buckley, Marilyn] US Army, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. FU Defense Threat Reduction Agency FX We thank the Defense Threat Reduction Agency for generous support. NR 30 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2013 VL 178 IS 9 BP 1024 EP 1028 DI 10.7205/MILMED-D-13-00129 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UC UT WOS:000340805500020 PM 24005553 ER PT J AU Fentanes, E Wisenbaugh, TW AF Fentanes, Emilio Wisenbaugh, Thomas W. TI Ten Years of Percutaneous Coronary Intervention in a Low-Volume Military Treatment Facility: A Quality Improvement Project SO MILITARY MEDICINE LA English DT Article ID CARDIOVASCULAR DATA REGISTRY; DRUG-ELUTING STENTS; RISK PREDICTION; MORTALITY; THROMBOSIS; CARDIOLOGY; OUTCOMES; DISEASE AB Background: The quality assurance of a percutaneous coronary intervention (PCI) program is particularly important when the volume of procedures is low in the center. Purpose: Determine predictors of the 30-day and long-term incidence of stent thrombosis, myocardial infarction, and death from any cause for all PCIs performed at Tripler Army Medical Center from January 2002 to June 2012. Methods: 929 PCIs were performed in 795 patients, resulting in an average PCI volume of 88 per year. Follow-up data were obtained for 99.8% of the patients at 30 days and for 83% at 3 years. Results: 18 deaths occurred during the first 30 days after PCI, with an observed morality rate of 2.26%. Multivariate logistic regression identified independent predictors of death at 30 days: stent thrombosis (OR 96), acute myocardial infarction, hemodynamic instability (OR 47), emergent (OR 17) or salvage (OR 28) PCI, and the need for preprocedural balloon pumping (OR 27). The long-term survival Kaplan-Meier estimates were 94% at 1 year and 90.4% at 3 years. Conclusion: The 30-day mortality was similar to the expected mortality based on the risk factors in the New York State Registry model, and long-term survival was comparable with that reported in large registries. C1 [Fentanes, Emilio; Wisenbaugh, Thomas W.] Tripler Army Med Ctr, ATTN MCHK DM, Honolulu, HI 96859 USA. RP Fentanes, E (reprint author), Tripler Army Med Ctr, ATTN MCHK DM, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 21 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2013 VL 178 IS 9 BP 1029 EP 1035 DI 10.7205/MELMED-D-13-00148 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UC UT WOS:000340805500021 PM 24005554 ER PT J AU Khilyas, IV Ziganshin, AM Pannier, AJ Gerlach, R AF Khilyas, Irina V. Ziganshin, Ayrat M. Pannier, Andy J. Gerlach, Robin TI Effect of ferrihydrite on 2,4,6-trinitrotoluene biotransformation by an aerobic yeast SO BIODEGRADATION LA English DT Article DE 2,4,6-Trinitrotoluene; Biodegradation; Ferrihydrite; Yeast; Nitroaromatics ID NITRIC-OXIDE; PHANEROCHAETE-CHRYSOSPORIUM; NITROAROMATIC COMPOUNDS; YARROWIA-LIPOLYTICA; IRON METAL; DEGRADATION; TRANSFORMATION; TNT; REDUCTION; BIODEGRADATION AB This study investigated the impact of ferrihydrite on the pathway and rate of 2,4,6-trinitrotoluene (TNT) transformation by Yarrowia lipolytica AN-L15. The presence of ferrihydrite in the culture medium decreased the rate of TNT biotransformation but resulted in the accumulation of the same TNT metabolites as in the absence of ferrihydrite, albeit at slightly different concentrations. Transformation products observed included aromatic ring reduction products, such as hydride-Meisenheimer complexes, and nitro group reduction products, such as hydroxylamino- and amino-dinitrotoluenes. Independently of the presence of ferrihydrite the subsequent degradation of the hydride complex(es) resulted in the release of nitrite followed by its conversion to nitrate and nitric oxide at the low pH values observed during yeast cultivation. Nitric oxide generation was ascertained by electron spin resonance spectroscopy. In addition, increased Fe3+-reduction was observed in the presence of TNT and Y. lipolytica. This study demonstrates that in the presence of yeast cells, TNT-hydride complexes were formed at approximately the same level as in the presence of ferrihydrite, opening up the possibility of aromatic ring cleavage, instead of promoting the production of potentially toxic nitro group reduction products in the presence of iron minerals. C1 [Khilyas, Irina V.; Ziganshin, Ayrat M.] Kazan Volga Reg Fed Univ, Dept Microbiol, Kazan 420008, The Republic Of, Russia. [Pannier, Andy J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Pannier, Andy J.; Gerlach, Robin] Montana State Univ, Ctr Biofilm Engn, Bozeman, MT 59717 USA. [Gerlach, Robin] Montana State Univ, Dept Chem & Biol Engn, Bozeman, MT 59717 USA. RP Ziganshin, AM (reprint author), Kazan Volga Reg Fed Univ, Dept Microbiol, Ul Kremlyovskaya 18, Kazan 420008, The Republic Of, Russia. EM a.ziganshin06@fulbrightmail.org; robin_g@erc.montana.edu RI Gerlach, Robin/A-9474-2012 FU Ministry of Education and Science of the Russian Federation; Republic of Tatarstan (Russia); US Department of Defense, Army Research Office [DAAD19-03-C-0103]; Office of Science (BER), U.S. Department of Energy [DE-FG02-03ER63582]; Defense University Research Instrumentation Program (DURIP) [W911NF0510255] FX This work was supported by a grant from the Ministry of Education and Science of the Russian Federation (2010-2011) and partially supported by a grant "Algaris'' from the Republic of Tatarstan (Russia). Partial financial support was provided by the US Department of Defense, Army Research Office, Grant No. DAAD19-03-C-0103 and the Office of Science (BER), U.S. Department of Energy, Grant No. DE-FG02-03ER63582. The authors acknowledge funding for the establishment of the Environmental and Biofilm Mass Spectrometry Facility through the Defense University Research Instrumentation Program (DURIP) Contract No. W911NF0510255. We gratefully acknowledge Alexander Rodionov (Institute of Physics, Kazan Federal University) for ESR spectroscopy assistance. NR 51 TC 6 Z9 6 U1 0 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0923-9820 EI 1572-9729 J9 BIODEGRADATION JI Biodegradation PD SEP PY 2013 VL 24 IS 5 BP 631 EP 644 DI 10.1007/s10532-012-9611-4 PG 14 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 192YU UT WOS:000322524700005 PM 23239085 ER PT J AU Gose, WA Hanson, RE Harmer, RE Seidel, EK AF Gose, W. A. Hanson, R. E. Harmer, R. E. Seidel, E. K. TI Reconnaissance paleomagnetic studies of Mesoproterozoic alkaline igneous complexes in the Kaapvaal craton, South Africa SO JOURNAL OF AFRICAN EARTH SCIENCES LA English DT Article DE Paleomagnetism; Mesoproterozoic; Alkaline igneous complexes; Apparent polar wander path; Kaapvaal craton; Pilanesberg alkaline province ID APPARENT POLAR WANDER; SUPERCONTINENT NUNA; KALAHARI CRATON; SIERRA-NEVADA; KORAS GROUP; RODINIA; MAGMATISM; RECONSTRUCTIONS; CONFIGURATION; DISPLACEMENT AB We report paleomagnetic data from three different parts of a diffuse Mesoproterozoic alkaline igneous province in the eastern part of the Kaapvaal craton in South Africa. Except for the similar to 1.3 Ga Pilanesberg dikes, these rocks have not previously been studied paleomagnetically. Isotopic dates from igneous rocks in the province generally indicate emplacement between 1.4 and 1.35 Ga, which falls in a time frame where the apparent polar wander path (APWP) for the Kaapvaal craton is poorly known. In order to help address this problem, we report paleomagnetic data for syenitic rocks in the large Pilanesberg Complex near the western limit of the alkaline province, two separate syenitic intrusions in the Pienaars River Complexes near Pretoria, and the Spitskop ijolite-nepheline syenite-carbonatite complex near the eastern limit of the province. These intrusive units yield poles that allow a tentative extension of the Mesoproterozoic Kaapvaal APWP back to 1.4 Ga. The data suggest a pronounced bend or cusp in the APWP at 1.1 Ga, which may record a major change in plate motion occurring at the same time as emplacement of the Umkondo large igneous province in southern Africa. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Gose, W. A.] Univ Texas Austin, Jackson Sch Geosci, Austin, TX 78712 USA. [Hanson, R. E.] Texas Christian Univ, Sch Geol Energy & Environm, Ft Worth, TX 76129 USA. [Harmer, R. E.] Galileo Resources, London SW7 2JE, England. [Seidel, E. K.] US Army Corps Engineers, Ft Worth, TX 76102 USA. RP Hanson, RE (reprint author), Texas Christian Univ, Sch Geol Energy & Environm, Ft Worth, TX 76129 USA. EM wulfgose@gmail.com; r.hanson@tcu.edu; jock.harmer@xsinet.co.za; seidemi@gmail.com FU National Science Foundation (Tectonics Program) [EAR 9909269, 0510690, EAR 9909854, EAR 0510613] FX This work was partly supported by National Science Foundation (Tectonics Program) Grants EAR 9909269 and 0510690 to R. Hanson, EAR 9909854 to W. Gose and I. Dalziel and EAR 0510613 to Gose. We thank Carlos Martins for access to the Franspoort nepheline syenite quarry and for generously sharing geological information with us. Careful reviews by Richard Ernst and Joe Meert caused us to sharpen our thinking and resulted in significant improvements in the manuscript. NR 52 TC 3 Z9 3 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1464-343X J9 J AFR EARTH SCI JI J. Afr. Earth Sci. PD SEP PY 2013 VL 85 BP 22 EP 30 DI 10.1016/j.jafrearsci.2013.04.005 PG 9 WC Geosciences, Multidisciplinary SC Geology GA 193JS UT WOS:000322556700003 ER PT J AU Cartagena, CM Phillips, KL Williams, GL Konopko, M Tortella, FC Dave, JR Schmid, KE AF Cartagena, Casandra M. Phillips, Katie L. Williams, Garry L. Konopko, Melissa Tortella, Frank C. Dave, Jitendra R. Schmid, Kara E. TI Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3 SO NEUROMOLECULAR MEDICINE LA English DT Article DE NNZ-2566; Penetrating ballistic-like brain injury; Traumatic brain injury ID TRAUMATIC BRAIN-INJURY; NATURAL-KILLER-CELLS; GLY-PRO-GLU; RAT MODEL; IN-VIVO; GLYPROMATE ANALOG; NERVOUS-SYSTEM; EXPRESSION; ASTROCYTES; ENCEPHALOMYELITIS AB The tripeptide glycine-proline-glutamate analogue NNZ-2566 (Neuren Pharmaceuticals) demonstrates neuroprotective efficacy in models of traumatic brain injury. In penetrating ballistic-like brain injury (PBBI), it significantly decreases injury-induced upregulation of inflammatory cytokines including TNF-alpha, IFN-gamma, and IL-6. However, the mechanism by which NNZ-2566 acts has yet to be determined. The activating transcription factor-3 (ATF3) is known to repress expression of these inflammatory cytokines and was increased at the mRNA and protein level 24-h post-PBBI. This study investigated whether 12 h of NNZ-2566 treatment following PBBI alters atf3 expression. PBBI alone significantly increased atf3 mRNA levels by 13-fold at 12 h and these levels were increased by an additional fourfold with NNZ-2566 treatment. To confirm that changes in mRNA translated to changes in protein expression, ATF3 expression levels were determined in vivo in microglia/macrophages, T cells, natural killer cells (NKCs), astrocytes, and neurons. PBBI alone significantly increased ATF3 in microglia/macrophages (820 %), NKCs (58 %), and astrocytes (51 %), but decreased levels in T cells (48 %). NNZ-2566 treatment further increased ATF3 protein expression in microglia/macrophages (102 %), NKCs (308 %), and astrocytes (13 %), while reversing ATF3 decreases in T cells. Finally, PBBI increased ATF3 levels by 55 % in neurons and NNZ-2566 treatment further increased these levels an additional 33 %. Since increased ATF3 may be an innate protective mechanism to limit inflammation following injury, these results demonstrating that the anti-inflammatory and neuroprotective drug NNZ-2566 increase both mRNA and protein levels of ATF3 in multiple cell types provide a cellular mechanism for NNZ-2566 modulation of neuroinflammation following PBBI. C1 [Cartagena, Casandra M.; Phillips, Katie L.; Williams, Garry L.; Konopko, Melissa; Tortella, Frank C.; Dave, Jitendra R.; Schmid, Kara E.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Cartagena, CM (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM casandra.cartagena@us.army.mil; katie.phillips1@us.army.mil; garryleejr@hotmail.com; melissa.konopko@gmail.com; frank.c.tortella@us.army.mil; jitendra.ramanlal.dave@us.army.mil; kara.schmid@us.army.mil OI Konopko, Melissa/0000-0001-9515-398X FU Neuren Pharmaceuticals Ltd. [W81XWH-05-0074] FX We would like to thank Matthew Bombard and Weihong Yang for their excellent assistance with surgical procedures. These studies were supported in part by a cooperative research and development agreement with Neuren Pharmaceuticals Ltd. (W81XWH-05-0074). This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or reflecting true views of the Department of the Army or the Department of Defense. NR 43 TC 6 Z9 6 U1 2 U2 8 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1535-1084 J9 NEUROMOL MED JI Neuromol. Med. PD SEP PY 2013 VL 15 IS 3 BP 504 EP 514 DI 10.1007/s12017-013-8236-z PG 11 WC Neurosciences SC Neurosciences & Neurology GA 195RW UT WOS:000322722300006 PM 23765588 ER PT J AU Darling, KA Tschopp, MA Roberts, AJ Ligda, JP Kecskes, LJ AF Darling, K. A. Tschopp, M. A. Roberts, A. J. Ligda, J. P. Kecskes, L. J. TI Enhancing grain refinement in polycrystalline materials using surface mechanical attrition treatment at cryogenic temperatures SO SCRIPTA MATERIALIA LA English DT Article DE Nanocrystalline; SMAT; Cryogenic; Deformation ID NANOSTRUCTURE FORMATION; NANOCRYSTALLINE NI; STAINLESS-STEEL; CARBON-STEEL; GROWTH; LAYER; COPPER; DEFORMATION; SMAT AB The surface mechanical attrition treatment (SMAT) process was applied to pure Cu at both cryogenic and room temperatures. The cryogenic SMAT process resulted in a 60% reduction of grain size in the polycrystalline microstructure compared to that at room temperature. The level of grain refinement is related to a transition in the dominant deformation mechanism during SMAT from a dislocation-mediated behavior at room temperature to a twinning/shear band-mediated behavior at cryogenic temperatures, which also helps to suppress thermally activated processes. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Darling, K. A.; Tschopp, M. A.; Roberts, A. J.; Ligda, J. P.; Kecskes, L. J.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Darling, KA (reprint author), Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kristopher.darling.civ@mail.mil RI Kecskes, Laszlo/F-6880-2014; Tschopp, Mark/B-1594-2008 OI Kecskes, Laszlo/0000-0002-1342-3729; Tschopp, Mark/0000-0001-8471-5035 FU U.S. Army Research Laboratory (ARL); Oak Ridge Institute for Science and Education U.S. Department of Energy; ARL FX The authors would like to acknowledge Micah Gallagher (Bowhead) for his valuable input for experimental design and Suveen Mathaudhu (ARO) for transitioning this technology to the Army Research Laboratory. MAT, AJR, and JPL would like to acknowledge support from the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 21 TC 17 Z9 18 U1 5 U2 56 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP PY 2013 VL 69 IS 6 BP 461 EP 464 DI 10.1016/j.scriptamat.2013.05.036 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 191QS UT WOS:000322428300008 ER PT J AU Li, B Ma, Q McClelland, Z Horstemeyer, SJ Whittington, WR Brauer, S Allison, PG AF Li, B. Ma, Q. McClelland, Z. Horstemeyer, S. J. Whittington, W. R. Brauer, S. Allison, P. G. TI Twin-like domains and fracture in deformed magnesium SO SCRIPTA MATERIALIA LA English DT Article DE Fracture; Twinning; Magnesium; EBSD ID STACKING-FAULT; PYRAMIDAL SLIP; DISLOCATION; DEFORMATION; CRYSTALS; ALLOY; PLASTICITY; BOUNDARIES; MECHANISMS; METALS AB Twin-like domains were observed in deformed magnesium by using electron backscatter diffraction. These domains do not satisfy any of the known twin orientation relationships, but have a high misorientation angle of similar to 57 degrees and a rotation axis of < 1 0 (1) over bar 0 >. Fracture occurred primarily in these domains. {1 0 (1) over bar 2}< 1 0 (1) over bar (1) over bar > twins were observed at the domain/matrix interfaces, and these twins may relax local stress and retard crack propagation. Trace analysis shows that the domains are likely on {1 0 (1) over bar 1} planes. Interaction between the domains may lead to crack nucleation. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Li, B.; Ma, Q.; McClelland, Z.; Horstemeyer, S. J.; Whittington, W. R.; Brauer, S.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. [Allison, P. G.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Li, B (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. EM binli@cavs.msstate.edu OI Allison, Paul/0000-0002-9041-237X FU Center for Advanced Vehicular Systems, Mississippi State University FX B.L., Q.M., Z.M., S.J.H., W.R.W. and S.B. thank the support from Center for Advanced Vehicular Systems, Mississippi State University. NR 22 TC 4 Z9 4 U1 1 U2 39 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP PY 2013 VL 69 IS 6 BP 493 EP 496 DI 10.1016/j.scriptamat.2013.06.014 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 191QS UT WOS:000322428300016 ER PT J AU McAllister, QP Gillespie, JW VanLandingham, MR AF McAllister, Quinn P. Gillespie, John W., Jr. VanLandingham, Mark R. TI The sub-micron scale energy dissipative deformation mechanisms of Kevlar fibrils SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ATOMIC-FORCE MICROSCOPY; POLY(PARA-PHENYLENE TEREPHTHALAMIDE) FIBERS; POLY(P-PHENYLENE TEREPHTHALAMIDE); INDENTATION EXPERIMENTS; SURFACE MICROSTRUCTURE; BIOPOLYMER FIBERS; ARAMID FIBERS; HARDNESS; POLYMER; FABRICS AB In this study, the energies to indent and scratch Kevlar 49 and Kevlar KM2 single fiber surfaces are investigated along with the associated deformation mechanisms of the fiber fibrillar network. For both indentation and scratching, values of energy are determined from the measured forces and displacements under a number of different contact conditions, which include variations in probe size, indentation/scratch depth, and scratch length. These values are correlated to the observed fibrillar deformation mechanisms. The total indentation energy is primarily recoverable for indentations made at low depths and/or by probes that impart low levels of effective strain. Indentations made to greater depths by probes imparting greater effective strains result in additional forms of deformation, which correlate with an increase in the percentage of the total energy that is absorbed and an increase in the total specific energy (energy per volume) of indentation. The energy of a constant depth scratch exceeds the energy of indentation for scratch lengths greater than similar to 1.5-3 times the indentation depth. The total specific energy of scratching decreases with the onset of microstructure failure, in the form of fibrillation, during scratching. The energies to indent and scratch Kevlar KM2 are generally lower than Kevlar 49, which is likely related to the decreased properties of the Kevlar KM2 shell and/or a difference in the local properties of the two fibers. The fibrillar deformation mechanisms critical to optimizing the specific energies of indentation and scratching, which depend on strain, are identified and discussed. C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Ctr Composite Mat, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [VanLandingham, Mark R.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP McAllister, QP (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. EM quinn.p.mcallister.ctr@mail.mil FU Army Research Laboratory [W911NF-06-2-0011] FX QM and JWG gratefully acknowledge sponsorship by the Army Research Laboratory under cooperative agreement W911NF-06-2-0011. The views and conclusions contained in this article should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes not withstanding any copyright notation herein. NR 41 TC 6 Z9 6 U1 1 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP PY 2013 VL 48 IS 18 BP 6245 EP 6261 DI 10.1007/s10853-013-7422-6 PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA 176EC UT WOS:000321285500018 ER PT J AU Perry, J Arkoudas, K Chiang, J Chadha, R Apgar, D Whittaker, K AF Perry, Jason Arkoudas, Konstantine Chiang, Jason Chadha, Ritu Apgar, Daniel Whittaker, Keith TI Modular natural language interfaces to logic-based policy frameworks SO COMPUTER STANDARDS & INTERFACES LA English DT Article DE Natural language; User interface; Policy; Computational semantics; Controlled natural language AB We have developed a translation system that maps sentences of Attempto Controlled English to predicates of many-sorted first-order logic, which can be directly imported into a logic-based policy management framework. Our translation achieves broader coverage than prior work that uses ACE, by a novel application of modern compositional semantics. This translation also natively supports question answering. The system significantly features a modular architecture, enabling semi-automated porting to new policy domains. We initially developed the system for cognitive radio policies, then generalized and ported it to two other policy vocabularies. The system interoperates with policies written in the XACML language. (C) 2013 Published by Elsevier B.V. C1 [Perry, Jason; Arkoudas, Konstantine; Chadha, Ritu] Appl Commun Sci, Piscataway, NJ 08854 USA. [Chiang, Jason] Appl Commun Sci, Autonomous Wireless Commun Grp, Piscataway, NJ 08854 USA. [Perry, Jason] Rutgers State Univ, Dept Comp Sci, Piscataway, NJ 08854 USA. [Apgar, Daniel; Whittaker, Keith] USA, CERDEC, Aberdeen, MD USA. RP Perry, J (reprint author), Appl Commun Sci, Piscataway, NJ 08854 USA. EM jasperry@cs.rutgers.edu; karkoudas@appcomsci.com; jchiang@appcomsci.com; rchadha@appcomsci.com; daniel.d.apgar.civ@mail.mil; keith.d.whittaker.civ@mail.mil FU U.S. Army Communications Electronics Research and Development Engineering Center (CERDEC) [W15P7T-08-C-P213] FX The research reported in this paper was performed in connection with contract number W15P7T-08-C-P213 with the U.S. Army Communications Electronics Research and Development Engineering Center (CERDEC). The views and conclusions contained in this document are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the U.S. Army CERDEC, or the U.S. Government unless so designated by other authorized documents. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 23 TC 1 Z9 1 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-5489 J9 COMPUT STAND INTER JI Comput. Stand. Interfaces PD SEP PY 2013 VL 35 IS 5 BP 417 EP 427 DI 10.1016/j.csi.2013.02.002 PG 11 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA 170GC UT WOS:000320837400002 ER PT J AU Wolfenstine, J Allen, JL Read, J Sakamoto, J AF Wolfenstine, J. Allen, J. L. Read, J. Sakamoto, J. TI Chemical stability of cubic Li7La3Zr2O12 with molten lithium at elevated temperature SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID BETA-ALUMINA; SOLID-ELECTROLYTE; NASICON ELECTROLYTES; IONIC-CONDUCTIVITY; SODIUM; GARNET; FABRICATION; COLORATION; SYSTEM; NA AB Cubic garnet of nominal composition Li7La3Zr2O12 (LLZO) is of interest as a possible electrolyte in a Li-metal halide battery composed of molten Li and an insoluble metal halide as electrodes operating in the temperature range of similar to 300-350 A degrees C. As a consequence, the chemical stability of LLZO with molten Li in this temperature range was investigated. After heating in molten Li, the LLZO surface had undergone chemical coloration. X-diffraction, X-ray photoemission spectroscopy, electron paramagnetic resonance, and heat-treatment experiments suggest that chemical coloration is a result of the formation of color centers, composed of an electron trapped at an oxygen vacancy. It was also observed that after immersion in molten Li that LLZO exhibited intergranular cracking. It is believed that cracking results from stresses generated from an increased Li+ content, gained during immersion. C1 [Wolfenstine, J.; Allen, J. L.; Read, J.] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA. [Sakamoto, J.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Wolfenstine, J (reprint author), RDRL SED C, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.b.wolfenstine.civ@mail.mil FU Army Research Laboratory; US Army Research Office (ARO) FX JW, JAL, JR would like to acknowledge support of the Army Research Laboratory. JS would like to acknowledge the support of the US Army Research Office (ARO). NR 25 TC 15 Z9 15 U1 13 U2 133 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP PY 2013 VL 48 IS 17 BP 5846 EP 5851 DI 10.1007/s10853-013-7380-z PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 175YZ UT WOS:000321271100017 ER PT J AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung TI Contextual SVM Using Hilbert Space Embedding for Hyperspectral Classification SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Contextual support vector machine (CSVM); Hilbert space embedding (HSE); hyperspectral classification ID IMAGE CLASSIFICATION; KERNELS AB In this letter, a kernel-based contextual classification approach built on the principle of a newly introduced mapping technique, called Hilbert space embedding, is proposed. The proposed technique, called contextual support vector machine (SVM), is aimed at jointly exploiting both local spectral and spatial information in a reproducing kernel Hilbert space (RKHS) by collectively embedding a set of spectral signatures within a confined local region into a single point in the RKHS that can uniquely represent the corresponding local hyperspectral pixels. Embedding is conducted by calculating the weighted empirical mean of the mapped points in the RKHS to exploit the similarities and variations in the local spectral and spatial information. The weights are adaptively estimated based on the distance between the mapped point in consideration and its neighbors in the RKHS. An SVM separating hyperplane is built to maximize the margin between classes formed by weighted empirical means. The proposed technique showed significant improvement over the composite kernel-based SVM on several hyperspectral images. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM pkgurram@gmail.com; heesung.kwon.civ@mail.mil NR 13 TC 12 Z9 13 U1 0 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD SEP PY 2013 VL 10 IS 5 BP 1031 EP 1035 DI 10.1109/LGRS.2012.2227934 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 172IA UT WOS:000320993900013 ER PT J AU Allen, JL McOwen, DW Delp, SA Fox, ET Dickmann, JS Han, SD Zhou, ZB Jow, TR Henderson, WA AF Allen, Joshua L. McOwen, Dennis W. Delp, Samuel A. Fox, Eric T. Dickmann, James S. Han, Sang-Don Zhou, Zin-Bin Jow, T. Richard Henderson, Wesley A. TI N-Alkyl-N-methylpyrrolidinium difluoro(oxalato)borate ionic liquids: Physical/electrochemical properties and Al corrosion SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium-ion battery; LiDFOB; Electrolyte; Al corrosion; Ionic liquid ID ALUMINUM CURRENT COLLECTOR; TEMPERATURE MOLTEN-SALT; VERTICAL-BAR-AG+; ELECTROCHEMICAL INTERCALATION; PHASE-BEHAVIOR; GRAPHITE ANODE; LITHIUM; ELECTROLYTES; BATTERIES; BIS(FLUOROSULFONYL)IMIDE AB The synthesis and physical properties of difluoro(oxalato)borate (DFOB-)-based ionic liquids (ILs) are reported with N-alkyl-N-methylpyrrolidinium (PY1R+) cations with butyl, pentyl and hexyl alkyl chains. The PY14DFOB and PY16DFOB salts have a melting point (T-m) of -5 degrees C and 31 degrees C, respectively, whereas the PY15DFOB salt does not crystallize. Instead, this salt has a glass transition temperature (T-g) of -74 degrees C. Electrolytes composed of these ILs are noncorrosive toward Al when mixed with LiTFSI and LiFSI, as well as with LiPF6 or LiDFOB. The exceptional oxidative stability of these ILs suggests that they may be suitable for battery electrolyte applications. (C) 2013 Elsevier B.V. All rights reserved. C1 [Allen, Joshua L.; McOwen, Dennis W.; Delp, Samuel A.; Fox, Eric T.; Dickmann, James S.; Han, Sang-Don; Henderson, Wesley A.] N Carolina State Univ, Ion Liquids & Electrolytes Energy Technol ILEET L, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Zhou, Zin-Bin] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China. [Allen, Joshua L.; Jow, T. Richard] US Army Res Lab, Adelphi, MD 20783 USA. RP Henderson, WA (reprint author), N Carolina State Univ, Ion Liquids & Electrolytes Energy Technol ILEET L, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM whender@ncsu.edu RI McOwen, Dennis/N-3337-2014 OI McOwen, Dennis/0000-0002-1313-1574 FU U.S. DOE BATT Program [DE-AC02-05-CH11231]; American Society for Engineering Education (ASEE) FX This work was fully funded by the U.S. DOE BATT Program (contract number DE-AC02-05-CH11231). The authors would like to thank Kim Hutchison (Department of Soil Science, North Carolina State University) for the ICP-MS analysis and Dr. Hanna Gracz (Biomolecular NMR Facility, North Carolina State University) for the 11B NMR analysis. J.L.A. would like to thank the SMART Scholarship Program and the American Society for Engineering Education (ASEE) for the award of a SMART Graduate Research Fellowship. NR 42 TC 10 Z9 12 U1 4 U2 59 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD SEP 1 PY 2013 VL 237 BP 104 EP 111 DI 10.1016/j.jpowsour.2013.02.086 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 173NH UT WOS:000321085700016 ER PT J AU Freberg, K Saling, K Vidoloff, KG Eosco, G AF Freberg, Karen Saling, Kristin Vidoloff, Kathleen G. Eosco, Gina TI Using value modeling to evaluate social media messages: The case of Hurricane Irene SO PUBLIC RELATIONS REVIEW LA English DT Article DE Crisis communications; Social media; Reputation management; Value modeling techniques ID CRISIS COMMUNICATION; RISK AB Emerging technologies, advances in social media, and new communication platforms have transformed how crisis communicators reach their audiences and partner agencies in a variety of situations. Not only do individuals and organizations communicate differently during a crisis, but they are also perceived very differently; social media platforms and messages add to the challenges involved in maintaining the overall reputation of brands and corporations. To better understand the new messaging system and its effects, the researchers analyzed social media crisis messages and messaging theory through various qualitative and quantitative value modeling techniques and generated a simple baseline model for what constitutes a "good" crisis message. Using data collected during Hurricane Irene, the researchers used this baseline model to rank effective and ineffective messages to determine whether the most followed/forwarded messages fit this model, and to identify a set of new best practices for crisis communicators and reputation management monitors using social media platforms. (C) 2013 Elsevier Inc. All rights reserved. C1 [Freberg, Karen] Univ Louisville, Louisville, KY 40292 USA. [Saling, Kristin] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Eosco, Gina] Cornell Univ, Ithaca, NY 14853 USA. RP Freberg, K (reprint author), Univ Louisville, 310 Strickler Hall, Louisville, KY 40292 USA. EM karen.freberg@louisville.edu; kristin.saling@usma.edu; Kathleen.G.Vidoloff@state.or.us; eosco@ametsoc.org NR 48 TC 9 Z9 9 U1 6 U2 68 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0363-8111 J9 PUBLIC RELAT REV JI Public Relat. Rev. PD SEP PY 2013 VL 39 IS 3 BP 185 EP 192 DI 10.1016/j.pubrev.2013.02.010 PG 8 WC Business; Communication SC Business & Economics; Communication GA 162UZ UT WOS:000320292800004 ER PT J AU Brunye, TT Hayes, JF Mahoney, CR Gardony, AL Taylor, HA Kanarek, RB AF Brunye, Tad T. Hayes, Jackie F. Mahoney, Caroline R. Gardony, Aaron L. Taylor, Holly A. Kanarek, Robin B. TI Get in My Belly: Food Preferences Trigger Approach and Avoidant Postural Asymmetries SO PLOS ONE LA English DT Article ID FRONTAL BRAIN ACTIVITY; SELECTIVE ATTENTION; APPETITIVE STIMULI; NUCLEUS-ACCUMBENS; HEDONIC IMPACT; DRUG-ADDICTION; EMOTION; HUNGER; REWARD; MOTIVATION AB Appetitive motivational states are fundamental neural and behavioral mechanisms underlying healthy and abnormal eating behavior, though their dynamic influence on food-related behavior is unknown. The present study examined whether personal food-related preferences would activate approach and avoidance systems, modulating spontaneous postural sway toward and away from food items. Participants stood on a balance board that collected real-time data regarding postural sway along two axes (x, y) while they viewed a series of images depicting food items varying in nutritional value and individual preferences. Overall, participants showed reliable postural sway toward highly preferred and away from highly non-preferred items. This effect became more pronounced over time; sway along the mediolateral axis showed no reliable variation by preference. Results carry implications for two-factor (homeostatic versus hedonic) neurobehavioral theories of hunger and appetitive motivation, and carry applied clinical implications for the measurement and management of abnormal eating behavior. C1 [Brunye, Tad T.; Hayes, Jackie F.; Mahoney, Caroline R.; Gardony, Aaron L.; Taylor, Holly A.; Kanarek, Robin B.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Kanarek, Robin B.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA. [Brunye, Tad T.; Hayes, Jackie F.; Mahoney, Caroline R.; Gardony, Aaron L.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, Medford, MA 02155 USA. EM tbrunye@alumni.tufts.edu FU United States Army [W911QY-09-C-0219] FX Parts of this work were supported by United States Army contract #W911QY-09-C-0219 to author HAT. The opinions expressed herein are those of the authors and not necessarily of the United States Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. NR 73 TC 3 Z9 3 U1 1 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 30 PY 2013 VL 8 IS 8 AR UNSP e72432 DI 10.1371/journal.pone.0072432 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 211BX UT WOS:000323880200013 PM 24023618 ER PT J AU Kamau, E Alemayehu, S Feghali, KC Saunders, D Ockenhouse, CF AF Kamau, Edwin Alemayehu, Saba Feghali, Karla C. Saunders, David Ockenhouse, Christian F. TI Multiplex qPCR for Detection and Absolute Quantification of Malaria SO PLOS ONE LA English DT Article ID POLYMERASE-CHAIN-REACTION; PLASMODIUM-FALCIPARUM; QUANTITATIVE PCR; DIAGNOSIS; SENSITIVITY; PARASITES; TRIALS; IMPACT; ASSAY; VIVO AB We describe development of an absolute multiplex quantitative real-time PCR for detection of Plasmodium spp., P. falciparum and P. vivax targets in order to produce an assay amenable to high throughput but with reduced costs. Important qPCR experimental details and information that is critical to performance and reliability of assay results were investigated. Inhibition studies were performed to test and compare co-purification of PCR inhibitors in samples extracted from whole blood using either the manual or automated methods. To establish the most optimal qPCR reaction volume, volume titration of the reaction master mix was performed starting at 10 mu l to 1 mu l reaction master mix with 1 mu l of template DNA in each reaction. As the reaction volume decreased, qPCR assays became more efficient with 1 mu l reaction master mix being the most efficient. For more accurate quantification of parasites in a sample, we developed plasmid DNAs for all the three assay targets for absolute quantification. All of absolute qPCR assays performed with efficiency of more than 94%, R-2 values greater than 0.99 and the STDEV of each replicate was <0.167. Linear regression plots generated from absolute qPCR assays were used to estimate the corresponding parasite density from relative qPCR in terms of parasite/mu l. One copy of plasmid DNA was established to be equivalent to 0.1 parasite/mu l for Plasmodium spp. assay, 0.281 parasites for P. falciparum assay and 0.127 parasite/mu l for P. vivax assay. This study demonstrates for the first time use of plasmid DNA in absolute quantification of malaria parasite. The use of plasmid DNA standard in quantification of malaria parasite will be critical as efforts are underway to harmonize molecular assays used in diagnosis of malaria. C1 [Kamau, Edwin; Alemayehu, Saba; Feghali, Karla C.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Saunders, David] USAMC, AFRIMS, Dept Immunol & Med, Bangkok, Thailand. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM edwin.kamau@us.army.mil NR 20 TC 21 Z9 21 U1 1 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 29 PY 2013 VL 8 IS 8 AR e71539 DI 10.1371/journal.pone.0071539 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 209DO UT WOS:000323734600006 PM 24009663 ER PT J AU Xu, DW He, HY Pandey, R Karna, SP AF Xu, Dongwei He, Haiying Pandey, Ravindra Karna, Shashi P. TI Stacking and electric field effects in atomically thin layers of GaN SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID GENERALIZED GRADIENT APPROXIMATION; DENSITY-FUNCTIONAL CALCULATIONS; MOLECULAR-BEAM EPITAXY; TRILAYER GRAPHENE; POWER DEVICES; BORON-NITRIDE; AB-INITIO; BAND-GAP; FILMS; HETEROSTRUCTURES AB Atomically thin layers of nitrides are a subject of interest due to their novel applications. In this paper, we focus on GaN multilayers, investigating their stability and the effects of stacking and electric fields on their electronic properties in the framework of density functional theory. Both bilayers and trilayers prefer a planar configuration rather than a buckled bulk-like configuration. The application of an external perpendicular electric field induces distinct stacking-dependent features in the electronic properties of nitride multilayers: the band gap of a monolayer does not change whereas that of a trilayer is significantly reduced. Such a stacking-dependent tunability of the band gap in the presence of an applied field suggests that multilayer GaN is a good candidate material for next generation devices at the nanoscale. C1 [Xu, Dongwei; He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Xu, DW (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM hhe@mtu.edu; pandey@mtu.edu FU Army Research Laboratory [W911NF-09-2-0026] FX Helpful discussions with Professor Jun Ni and Xiao-liang Zhong are acknowledged. The work at Michigan Technological University was performed under support by the Army Research Laboratory through Contract Number W911NF-09-2-0026. NR 51 TC 18 Z9 18 U1 1 U2 28 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 EI 1361-648X J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD AUG 28 PY 2013 VL 25 IS 34 AR 345302 DI 10.1088/0953-8984/25/34/345302 PG 11 WC Physics, Condensed Matter SC Physics GA 198XG UT WOS:000322956200004 PM 23896638 ER PT J AU Kannan, L Kis-Toth, K Yoshiya, K Thai, TH Sehrawat, S Mayadas, TN Lucca, JJD Tsokos, GC AF Kannan, Lakshmi Kis-Toth, Katalin Yoshiya, Kazuhisa Thai, To-Ha Sehrawat, Seema Mayadas, Tanya N. Lucca, Jurandir J. Dalle Tsokos, George C. TI R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE permeability; tissue repair; organ damage; junctional integrity ID ISCHEMIA-REPERFUSION INJURY; WNT PATHWAY; ACTIVATION; FAMILY; MICE; PERMEABILITY; DYSFUNCTION; MECHANISMS; EXPRESSION; PROTECTS AB Inflammation and vascular injury triggered by ischemia/reperfusion (I/R) represent a leading cause of morbidity and mortality in a number of clinical settings. Wnt and its homolog partners R-spondins, in addition to regulating embryonic development have recently been demonstrated to serve as wound-healing agents in inflammation-associated conditions. Here we ask whether R-spondins could prevent inflammation-associated tissue damage in ischemic disorders and thus investigate the role of R-spondin3 (R-spo3) in a mouse model of mesenteric I/R. We demonstrate that R-spo3 ameliorates mesenteric I/R-induced local intestinal as well as remote lung damage by suppressing local and systemic cytokine response and deposition of IgM and complement in intestinal tissues. We also show that decreased inflammatory response is accompanied by tightening of endothelial cell junctions and reduction in vascular leakage. We conclude that R-spo3 stabilizes endothelial junctions and inhibits vascular leakage during I/R and thereby mitigates the inflammatory events and associated tissue damage. Our findings uniquely demonstrate a protective effect of R-spo3 in I/R-related tissue injury and suggest a mechanism by which it may have these effects. C1 [Kannan, Lakshmi; Kis-Toth, Katalin; Yoshiya, Kazuhisa; Thai, To-Ha; Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med, Boston, MA 02115 USA. [Sehrawat, Seema; Mayadas, Tanya N.] Harvard Univ, Dept Pathol, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Lucca, Jurandir J. Dalle] US Army Inst Surg Res, Immunomodulat Trauma Program, San Antonio, TX 78234 USA. RP Kannan, L (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med, Boston, MA 02115 USA. EM lkannan@bidmc.harvard.edu; gtsokos@bidmc.harvard.edu FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530, W81XWH-09-1-0536] FX We thank Dr. Deepak Venkatesh for technical help and providing materials, Robin Bosse, Dr. Masayuki Mizui, and Dr. Takashi Muroya for technical help, and Dr. Kamalpreet Nagpal for reviewing the manuscript. The research presented herein was supported by Grants W81XWH-09-1-0530 and W81XWH-09-1-0536 from Medical Research and Material Command of the Department of the Army. NR 34 TC 7 Z9 7 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 27 PY 2013 VL 110 IS 35 BP 14348 EP 14353 DI 10.1073/pnas.1309393110 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 206ZC UT WOS:000323564600058 PM 23942120 ER PT J AU Lanzillo, NA Birdwell, AG Amani, M Crowne, FJ Shah, PB Najmaei, S Liu, Z Ajayan, PM Lou, J Dubey, M Nayak, SK O'Regan, TP AF Lanzillo, Nicholas A. Birdwell, A. Glen Amani, Matin Crowne, Frank J. Shah, Pankaj B. Najmaei, Sina Liu, Zheng Ajayan, Pulickel M. Lou, Jun Dubey, Madan Nayak, Saroj K. O'Regan, Terrance P. TI Temperature-dependent phonon shifts in monolayer MoS2 SO APPLIED PHYSICS LETTERS LA English DT Article ID VAPOR-PHASE GROWTH; ATOMIC LAYERS; DYNAMICS AB We present a combined experimental and computational study of two-dimensional molybdenum disulfide and the effect of temperature on the frequency shifts of the Raman-active E-2g and A(1g) modes in the monolayer. While both peaks show an expected red-shift with increasing temperature, the frequency shift is larger for the A(1g) mode than for the E-2g mode. This is in contrast to previously reported bulk behavior, in which the E-2g mode shows a larger frequency shift with temperature. The temperature dependence of these phonon shifts is attributed to the anharmonic contributions to the ionic interaction potential in the two-dimensional system. (C) 2013 AIP Publishing LLC. C1 [Lanzillo, Nicholas A.; Nayak, Saroj K.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Birdwell, A. Glen; Amani, Matin; Crowne, Frank J.; Shah, Pankaj B.; Dubey, Madan; O'Regan, Terrance P.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Nayak, Saroj K.] Indian Inst Technol, Sch Basic Sci, Bhubaneswar 751007, Orissa, India. RP Lanzillo, NA (reprint author), Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, 110 8th St, Troy, NY 12180 USA. RI Liu, Zheng/C-1813-2014 OI Liu, Zheng/0000-0002-8825-7198 FU Army Research Lab Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA); State of New York; Welch Foundation [C-1716]; NSF [ECCS-1327093]; U.S. Army Research Office MURI [W911NF-11-1-0362]; U.S. Office of Naval Research MURI [N000014-09-1-1066]; FAME Center, one of six centers of STARnet; MARCO; DARPA FX This work used computational resources provided by the Computational Center for Nanotechnology Innovations (CCNI) at Rensselaer Polytechnic Institute. S.K.N. and N.A.L. acknowledge support by the Army Research Lab Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA), as well as experimental work supported by the Director's Strategic Initiative (DSI) program on interfaces and stacked 2D atomic layered materials. S.K.N. and N.A.L. would like to thank Interconnect Focus Center at Rensselaer supported by State of New York and an anonymous gift from Rensselaer for part of the support for this work. S.N. and J.L. acknowledge support from Welch Foundation grant C-1716 and NSF grant ECCS-1327093. Z.L. and P. M. A. acknowledge the support by U.S. Army Research Office MURI grant W911NF-11-1-0362, the U.S. Office of Naval Research MURI grant N000014-09-1-1066, and the FAME Center, one of six centers of STARnet, a Semiconductor Research Corporation program sponsored by MARCO and DARPA. NR 22 TC 65 Z9 65 U1 4 U2 118 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 26 PY 2013 VL 103 IS 9 AR 093102 DI 10.1063/1.4819337 PG 4 WC Physics, Applied SC Physics GA 210PQ UT WOS:000323846900044 ER PT J AU Posse, S Ackley, E Mutihac, R Zhang, TS Hummatov, R Akhtari, M Chohan, M Fisch, B Yonas, H AF Posse, Stefan Ackley, Elena Mutihac, Radu Zhang, Tongsheng Hummatov, Ruslan Akhtari, Massoud Chohan, Muhammad Fisch, Bruce Yonas, Howard TI High-speed real-time resting-state fMRI using multi-slab echo-volumar imaging SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE real-time resting state fMRI; multi-slab echo-volumar imaging; independent component analysis (ICA); seed-based functional connectivity; cerebrovascular pulsatility; epilepsy; brain tumor; arteriovenous malformation ID INTRINSIC FUNCTIONAL CONNECTIVITY; INDEPENDENT COMPONENT ANALYSIS; SPONTANEOUS BRAIN ACTIVITY; GLOBAL SIGNAL REGRESSION; TEMPORAL RESOLUTION; PHYSIOLOGICAL NOISE; CORTICAL ACTIVITY; MOTOR CORTEX; SLICES PINS; WHOLE-BRAIN AB We recently demonstrated that ultra-high-speed real-time fMRI using multi-slab echo-volumar imaging (MEVI) significantly increases sensitivity for mapping task-related activation and resting-state networks (RSNs) compared to echo-planar imaging (Posse et al., 2012). In the present study we characterize the sensitivity of MEVI for mapping RSN connectivity dynamics, comparing independent component analysis (ICA) and a novel seed-based connectivity analysis (SBCA) that combines sliding-window correlation analysis with meta-statistics. This SBCA approach is shown to minimize the effects of confounds, such as movement, and CSF and white matter signal changes, and enables real-time monitoring of RSN dynamics at time scales of tens of seconds. We demonstrate highly sensitive mapping of eloquent cortex in the vicinity of brain tumors and arterio-venous malformations, and detection of abnormal resting-state connectivity in epilepsy. In patients with motor impairment, resting-state fMRI provided focal localization of sensorimotor cortex compared with more diffuse activation in task-based fMRI. The fast acquisition speed of MEVI enabled segregation of cardiac-related signal pulsation using ICA, which revealed distinct regional differences in pulsation amplitude and waveform, elevated signal pulsation in patients with arterio-venous malformations and a trend toward reduced pulsatility in gray matter of patients compared with healthy controls. Mapping cardiac pulsation in cortical gray matter may carry important functional information that distinguishes healthy from diseased tissue vasculature. This novel fMRI methodology is particularly promising for mapping eloquent cortex in patients with neurological disease, having variable degree of cooperation in task-based fMRI. In conclusion, ultra-high-real-time speed fMRI enhances the sensitivity of mapping the dynamics of resting-state connectivity and cerebro-vascular pulsatility for clinical and neuroscience research applications. C1 [Posse, Stefan; Ackley, Elena; Zhang, Tongsheng; Fisch, Bruce] Univ New Mexico, Sch Med, Dept Neurol, Albuquerque, NM 87131 USA. [Posse, Stefan] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. [Posse, Stefan; Hummatov, Ruslan] Univ New Mexico, Dept Phys & Astron, Albuquerque, NM 87131 USA. [Mutihac, Radu] Univ Bucharest, Dept Phys, Bucharest, Romania. [Mutihac, Radu] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. [Akhtari, Massoud] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA. [Chohan, Muhammad; Yonas, Howard] Univ New Mexico, Sch Med, Dept Neurosurg, Albuquerque, NM 87131 USA. RP Posse, S (reprint author), Univ New Mexico, Sch Med, Dept Neurol, 1 Univ New Mexico,MSC 105620, Albuquerque, NM 87131 USA. EM sposse@unm.edu OI Chohan, Muhammad/0000-0003-4542-4651 FU National Center for Research Resources [5P20RR021938-05]; National Institute of General Medical Sciences from the National Institutes of Health [8 P20 GM103472-05]; Department of Neurosurgery at UNM FX We gratefully acknowledge our patients for their participation. We thank Mona Chaney and Brittany Mead for assisting with patient recruitment and consenting. We gratefully acknowledge Diana South and Catherine Smith for assistance with scanner operations. Vineeth Yeruva assisted with operating the stimulus presentation. We thank Abhishek Reddy Yeruva, James Thrasher, and Daniel Allen McKearney for assistance with data analysis. We thank Eswar Damaraju (Mind Research Network) for advice on seed-based analysis using AFNI. The MEVI pulse sequence was developed in collaboration with Maxim Zaitsev and Jochen Rick (U. Freiburg, Germany), and Oliver Speck (U. Magdeburg, Germany). This project was supported in part by grants from the National Center for Research Resources (5P20RR021938-05) and the National Institute of General Medical Sciences (8 P20 GM103472-05) from the National Institutes of Health, and by the Department of Neurosurgery at UNM. We also thank the reviewers for their insightful comments. NR 102 TC 8 Z9 8 U1 0 U2 16 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD AUG 26 PY 2013 VL 7 AR UNSP 479 DI 10.3389/fnhum.2013.00479 PG 23 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 205XE UT WOS:000323477300001 PM 23986677 ER PT J AU Hen, N Shekh-Ahmad, T Yagen, B McDonough, JH Finnell, RH Wlodarczyk, B Bialer, M AF Hen, Naama Shekh-Ahmad, Tawfeeq Yagen, Boris McDonough, John H. Finnell, Richard H. Wlodarczyk, Bogdan Bialer, Meir TI Stereoselective Pharmacodynamic and Pharmacokinetic Analysis of sec-Butylpropylacetamide (SPD), a New CNS-Active Derivative of Valproic Acid with Unique Activity against Status Epilepticus SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SOMAN-INDUCED SEIZURES; ANTIEPILEPTIC DRUGS; MECHANISMS; DISCOVERY; 2ND-GENERATION; VALNOCTAMIDE; EPILEPSY; MODELS; ANALOG AB sec-Butylpropylacetamide (racemic-SPD) is a chiral CNS-active amide derivative of valproic acid (VPA). This study describes synthesis and stereospecific comparative pharmacodynamics (PD, anticonvulsant activity and teratogenicity) and pharmacokinetic (PK) analysis of four individual SPD stereoisomers. SPD stereoisomers' anticonvulsant activity was comparatively evaluated in several anticonvulsant animal models including the benzodiazepine-resistant status epilepticus (SE). SPD stereoisomers' PK-PD relationship was evaluated in rats. Teratogenicity of SPD stereoisomers was evaluated in SWV mice strain, susceptible to VPA-induced neural tube defect (NTD). SPD stereoisomers (141 or 283 mg/kg) did not cause NTD. SPD has stereoselective PK and PD. (2R,3S)-SPD and (2S,3R)-SPD higher clearance led to a 50% lower plasma exposure that may contribute to their relative lower activity in the pilocarpine-induced SE model. (2S,3S)-SPD, (2R,3R)-SPD, and racemic-SPD have similar anticonvulsant activity and a PK profile that are better than those of (2R,3S)-SPD and (2S,3R)-SPD, making them good candidates for development as new, potent antiepileptics with a potential in benzodiazepine-resistant SE. C1 [Hen, Naama; Shekh-Ahmad, Tawfeeq; Yagen, Boris; Bialer, Meir] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Inst Drug Res, IL-91120 Jerusalem, Israel. [Yagen, Boris; Bialer, Meir] Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel. [McDonough, John H.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD USA. [Finnell, Richard H.; Wlodarczyk, Bogdan] Univ Texas Austin, Dell Pediat Res Inst, Dept Nutr Sci, Austin, TX 78712 USA. RP Bialer, M (reprint author), Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Inst Drug Res, IL-91120 Jerusalem, Israel. EM bialer@md.huji.ac.il OI Wlodarczyk, Bogdan J./0000-0001-5249-5832 FU Israel Ministry of Defense, Medical Branch, Nuclear Biological Chemical (NBC) Protection Division [039-4489, 039-4576]; NINDS, NIH [NO1-NS-4-2359]; NIH/NINDS [Y1-O6-9613-01]; USAMRICD [A120-B.P2009-2] FX This study was supported by an unrestricted research grant (Grants 039-4489 and 039-4576) from Israel Ministry of Defense, Medical Branch, Nuclear Biological Chemical (NBC) Protection Division.; The authors thank Drs. John H. Kehne and Tracy Chen of the NIH-NINDS Anticonvulsant Screening Program (ASP) for testing the compounds in the ASP. The authors also acknowledge the technical assistance of the faculty and staff at the University of Utah Anticonvulsant Drug Development (ADD) Program who conducted the in vivo anticonvulsant testing, pilocarpine SE, and in vitro slice studies described in this manuscript. The anticonvulsant studies were supported by NINDS, NIH Contract NO1-NS-4-2359.; The studies conducted at USAMRICD were supported by an interagency agreement between NIH/NINDS (Grant Y1-O6-9613-01) and USAMRICD (Grant A120-B.P2009-2). The views expressed are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. The experimental protocol was approved by the Animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense, and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. NR 42 TC 9 Z9 9 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD AUG 22 PY 2013 VL 56 IS 16 BP 6467 EP 6477 DI 10.1021/jm4007565 PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 207IZ UT WOS:000323593400014 PM 23879329 ER PT J AU Liu, HJ Currano, L Gee, D Helms, T Yu, M AF Liu, Haijun Currano, Luke Gee, Danny Helms, Tristan Yu, Miao TI Understanding and mimicking the dual optimality of the fly ear SO SCIENTIFIC REPORTS LA English DT Article ID PARASITOID FLY; ORMIA-OCHRACEA; DIRECTIONAL HEARING; MICROPHONE; DIAPHRAGMS; EVOLUTION; LESSONS; SYSTEM AB The fly Ormia ochracea has the remarkable ability, given an eardrum separation of only 520 mm, to pinpoint the 5 kHz chirp of its cricket host. Previous research showed that the two eardrums are mechanically coupled, which amplifies the directional cues. We have now performed a mechanics and optimization analysis which reveals that the right coupling strength is key: it results in simultaneously optimized directional sensitivity and directional cue linearity at 5 kHz. We next demonstrated that this dual optimality is replicable in a synthetic device and can be tailored for a desired frequency. Finally, we demonstrated a miniature sensor endowed with this dual-optimality at 8 kHz with unparalleled sound localization. This work provides a quantitative and mechanistic explanation for the fly's sound-localization ability from a new perspective, and it provides a framework for the development of fly-ear inspired sensors to overcoming a previously-insurmountable size constraint in engineered sound-localization systems. C1 [Liu, Haijun; Yu, Miao] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Currano, Luke; Gee, Danny; Helms, Tristan] US Army Res Lab, Adelphi, MD 20783 USA. RP Yu, M (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM mmyu@umd.edu RI Yu, Miao/M-6252-2013; Liu, Haijun/A-5060-2016 OI Yu, Miao/0000-0003-4180-5094; FU NSF CAREER program [CMMI 0644914]; NSF [CMMI 1200420]; AFOSR Young Investigator program [FA95500810042] FX This work was supported by NSF CAREER program (CMMI 0644914), NSF grant (CMMI 1200420), and AFOSR Young Investigator program (FA95500810042). We thank Professor Elisabeth Smela for spending enormous time on helping us improve the paper. We also thank Ms. Latasha Solomon and Mr. Leng Sim at US Army Research Laboratory for accommodating the experiments in the anechoic chamber. The encouragement of Dr. Willard Larkin of AFOSR to pursue this work is also acknowledged. NR 25 TC 12 Z9 12 U1 2 U2 15 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD AUG 22 PY 2013 VL 3 AR 2489 DI 10.1038/srep02489 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 204LQ UT WOS:000323367200003 PM 23966060 ER PT J AU Lee, MS Olson, MA AF Lee, Michael S. Olson, Mark A. TI Comparison of volume and surface area nonpolar solvation free energy terms for implicit solvent simulations (vol 139, 044119, 2013) SO JOURNAL OF CHEMICAL PHYSICS LA English DT Correction C1 [Lee, Michael S.] US Army Res Lab, Computat Sci Div, Aberdeen, MD 21005 USA. [Lee, Michael S.; Olson, Mark A.] US Army Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Frederick, MD 21702 USA. RP Lee, MS (reprint author), US Army Res Lab, Computat Sci Div, Aberdeen, MD 21005 USA. EM michael.s.lee131.civ@mail.mil NR 1 TC 0 Z9 0 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 21 PY 2013 VL 139 IS 7 AR 079901 DI 10.1063/1.4819023 PG 1 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 206HN UT WOS:000323509900055 ER PT J AU Holloway, JL Lowman, AM VanLandingham, MR Palmese, GR AF Holloway, Julianne L. Lowman, Anthony M. VanLandingham, Mark R. Palmese, Giuseppe R. TI Chemical grafting for improved interfacial shear strength in UHMWPE/PVA-hydrogel fiber-based composites used as soft fibrous tissue replacements SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Fibers; Interfacial strength; Photoelectron spectroscopy (XPS); Plasma ID DOUBLE-NETWORK HYDROGELS; MECHANICAL-PROPERTIES; POLYMER COMPOSITES; ADHESION; CARTILAGE; MENISCUS AB Fiber-reinforced hydrogel composites offer a unique advantage for soft fibrous tissue applications due to their ability to reproduce the anisotropic property distribution present within these tissues. As for many composite materials, the fiber-matrix interface of hydrogel composites can severely limit composite performance. In particular, the fiber-hydrogel interface for poly(vinyl alcohol) (PVA) hydrogel composites reinforced with ultra high molecular weight polyethylene (UHMWPE) fibers was extremely poor due to the innate hydrophobicity of UHMWPE. To improve interfacial adhesion, a novel biocompatible PVA grafting technique utilizing oxygen plasma treatments to activate fiber surfaces was developed to form a direct covalent linkage at the fiber-matrix interface. Grafting was confirmed via scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Chemical grafting was tailored as a function of the number of sites available for covalent bonding and the percentage of sites reacted. Interfacial adhesion was determined for a range of grafting conditions using a single fiber pull-out test. PVA grafting resulted in significant improvements to interfacial shear strength from 11 kPa without any treatment to above 220 kPa following grafting. In some cases after grafting, failure was observed in tension within the fibers indicating the UHMWPE-PVA interface was successfully optimized. The results of this study can be used as a model for developing similar grafting techniques for other hydrogel-based composite systems. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Holloway, Julianne L.; Lowman, Anthony M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [VanLandingham, Mark R.] US Army Res Lab, Weap & Mat Res Director, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU National Defense Science and Engineering Graduate Fellowship; US Army Research Laboratory through the Army Materials Center of Excellence Program [W911NF-06-2-0013] FX Funding was provided through the National Defense Science and Engineering Graduate Fellowship, in addition to funding by the US Army Research Laboratory through the Army Materials Center of Excellence Program, Contract W911NF-06-2-0013. NR 27 TC 13 Z9 14 U1 8 U2 67 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD AUG 21 PY 2013 VL 85 BP 118 EP 125 DI 10.1016/j.compscitech.2013.06.007 PG 8 WC Materials Science, Composites SC Materials Science GA 204XT UT WOS:000323405300017 ER PT J AU Pettitt, J Zeitlin, L Kim, DH Working, C Johnson, JC Bohorov, O Bratcher, B Hiatt, E Hume, SD Johnson, AK Morton, J Pauly, MH Whaley, KJ Ingram, MF Zovanyi, A Heinrich, M Piper, A Zelko, J Olinger, GG AF Pettitt, James Zeitlin, Larry Kim, Do H. Working, Cara Johnson, Joshua C. Bohorov, Ognian Bratcher, Barry Hiatt, Ernie Hume, Steven D. Johnson, Ashley K. Morton, Josh Pauly, Michael H. Whaley, Kevin J. Ingram, Michael F. Zovanyi, Ashley Heinrich, Megan Piper, Ashley Zelko, Justine Olinger, Gene G. TI Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; DISEASE AB Ebola virus (EBOV) remains one of the most lethal transmissible infections and is responsible for high fatality rates and substantial morbidity during sporadic outbreaks. With increasing human incursions into endemic regions and the reported possibility of airborne transmission, EBOV is a high-priority public health threat for which no preventive or therapeutic options are currently available. Recent studies have demonstrated that cocktails of monoclonal antibodies are effective at preventing morbidity and mortality in nonhuman primates (NHPs) when administered as a post-exposure prophylactic within 1 or 2 days of challenge. To test whether one of these cocktails (MB-003) demonstrates efficacy as a therapeutic (after the onset of symptoms), we challenged NHPs with EBOV and initiated treatment upon confirmation of infection according to a diagnostic protocol for U.S. Food and Drug Administration Emergency Use Authorization and observation of a documented fever. Of the treated animals, 43% survived challenge, whereas both the controls and all historical controls with the same challenge stock succumbed to infection. These results represent successful therapy of EBOV infection in NHPs. C1 [Pettitt, James; Johnson, Joshua C.; Ingram, Michael F.; Zovanyi, Ashley; Heinrich, Megan; Piper, Ashley; Zelko, Justine; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Zeitlin, Larry; Kim, Do H.; Bohorov, Ognian; Pauly, Michael H.; Whaley, Kevin J.] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA. [Working, Cara; Bratcher, Barry; Hiatt, Ernie; Hume, Steven D.; Johnson, Ashley K.; Morton, Josh] Kentucky BioProc LLC, Owensboro 42301, KY USA. RP Olinger, GG (reprint author), US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. EM larry.zeitlin@mappbio.com; gene.olinger@us.army.mil OI Olinger, Gene/0000-0001-7338-0292 FU National Institute of Allergy and Infectious Diseases [AI61270, AI72915]; Department of Defense [DAMD 17-02-2-0015]; Defense Threat Reduction Agency [4.10007-08-RD-B] FX This work was supported by the National Institute of Allergy and Infectious Diseases grants AI61270 and AI72915 and the Department of Defense grant DAMD 17-02-2-0015, and it was partially supported by the Defense Threat Reduction Agency grant 4.10007-08-RD-B. NR 18 TC 75 Z9 81 U1 3 U2 9 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD AUG 21 PY 2013 VL 5 IS 199 AR 199ra113 DI 10.1126/scitranslmed.3006608 PG 6 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 205DT UT WOS:000323422600010 PM 23966302 ER PT J AU Rajdev, P Thorsley, D Rajaraman, S Rupp, TL Wesensten, NJ Balkin, TJ Reifman, J AF Rajdev, Pooja Thorsley, David Rajaraman, Srinivasan Rupp, Tracy L. Wesensten, Nancy J. Balkin, Thomas J. Reifman, Jaques TI A unified mathematical model to quantify performance impairment for both chronic sleep restriction and total sleep deprivation SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article DE Biomathematical models; Two-process model of sleep regulation; Neurocognitive performance; Chronic sleep restriction; Total sleep deprivation ID PSYCHOMOTOR VIGILANCE TEST; 2-PROCESS MODEL; NEUROBEHAVIORAL PERFORMANCE; DEPRIVED INDIVIDUALS; DOSE-RESPONSE; FATIGUE; RECOVERY; HOMEOSTASIS; WAKEFULNESS; PREDICTION AB Performance prediction models based on the classical two-process model of sleep regulation are reasonably effective at predicting alertness and neurocognitive performance during total sleep deprivation (TSD). However, during sleep restriction (partial sleep loss) performance predictions based on such models have been found to be less accurate. Because most modern operational environments are predominantly characterized by chronic sleep restriction (CSR) rather than by episodic TSD, the practical utility of this class of models has been limited. To better quantify performance during both CSR and TSD, we developed a unified mathematical model that incorporates extant sleep debt as a function of a known sleep/wake history, with recent history exerting greater influence. This incorporation of sleep/wake history into the classical two-process model captures an individual's capacity to recover during sleep as a function of sleep debt and naturally bridges the continuum from CSR to TSD by reducing to the classical two-process model in the case of TSD. We validated the proposed unified model using psychomotor vigilance task data from three prior studies involving TSD, CSR, and sleep extension. We compared and contrasted the fits, within-study predictions, and across-study predictions from the unified model against predictions generated by two previously published models, and found that the unified model more accurately represented multiple experimental studies and consistently predicted sleep restriction scenarios better than the existing models. In addition, we found that the model parameters obtained by fitting TSD data could be used to predict performance in other sleep restriction scenarios for the same study populations, and vice versa. Furthermore, this model better accounted for the relatively slow recovery process that is known to characterize CSR, as well as the enhanced performance that has been shown to result from sleep banking. Published by Elsevier Ltd. C1 [Rajdev, Pooja; Thorsley, David; Rajaraman, Srinivasan; Reifman, Jaques] USA, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, Ft Detrick, MD 21702 USA. [Rupp, Tracy L.; Wesensten, Nancy J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Reifman, J (reprint author), USA, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Program (MOMRP) of the US Army Medical Research and Materiel Command (Ft. Detrick, MD); US Defense Health Program [13200] FX This work was funded by the Military Operational Medicine Research Program (MOMRP) of the US Army Medical Research and Materiel Command (Ft. Detrick, MD), and by a Grant from US Defense Health Program (Award # 13200) managed by the MOMRP. NR 32 TC 11 Z9 11 U1 0 U2 19 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-5193 J9 J THEOR BIOL JI J. Theor. Biol. PD AUG 21 PY 2013 VL 331 BP 66 EP 77 DI 10.1016/j.jtbi.2013.04.013 PG 12 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 165JD UT WOS:000320478900008 PM 23623949 ER PT J AU Jeong, KI Venkatesan, MM Barnoy, S Tzipori, S AF Jeong, Kwang-il Venkatesan, Malabi M. Barnoy, Shoshana Tzipori, Saul TI Evaluation of virulent and live Shigella sonnei vaccine candidates in a gnotobiotic piglet model SO VACCINE LA English DT Article ID KERATOCONJUNCTIVITIS MODEL; DYSENTERIAE TYPE-1; FLEXNERI ANTIGENS; RHESUS-MONKEYS; WRSS1; IMMUNOGENICITY; INFECTION; EFFICACY; IMMUNIZATION; EXPRESSION AB Newborn gnotobiotic (GB) piglets given virulent Shigella orally develop many of the clinical symptoms and gastrointestinal (GI) manifestations that mimic human shigellosis. Shigella sonnei virulent strain Moseley, a mutant ShET2-1,2, lacking enterotoxin SenA and its paralog SenB, and vaccine candidates WRSS1 and WRSs3 were evaluated in this model for rates of diarrhea, colonization and other GI symptoms and pathology. Moseley-infected piglets developed diarrhea from 1 to 7 days, with the highest rates seen on days 2-4 after inoculation. In contrast, WRSs3-infected piglets did not have diarrhea over the entire experimental period. Compared to the Moseley group, lower diarrheal rates were observed in the double enterotoxin mutant and significantly lower in the WRSS1 group. Moseley infection also caused marked mucosal damage in the GI tissues at PID1 to PID8, and induced predominantly proinflammatory cytokine secretion. IL-8 and to a lesser extent IL-6 and IL-1 beta were observed early after inoculation and IL-12 secretion could be measured till late in infection. The ShET2-1,2 mutant, WRSS1 and WRSs3 also colonized the GI tract in a manner similar to Moseley; however, both vaccine candidates developed milder histopathological indices and cytokine responses. WRSs3-infected animals showed the least pathology. Furthermore, unlike the other strains, WRSs3 was rarely detected in organs outside the gastrointestinal tract. These results support the development of the GB piglet model as a sensitive in vivo oral model for the evaluation of virulence of different Shigella strains which could be applied to other oral vaccine candidates. (C) 2013 Published by Elsevier Ltd. C1 [Jeong, Kwang-il; Tzipori, Saul] Tufts Univ, Dept Infect Dis & Global Hlth, Cummings Sch Vet Med, North Grafton, MA 01536 USA. [Venkatesan, Malabi M.; Barnoy, Shoshana] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Tzipori, S (reprint author), Tufts Univ, Dept Infect Dis, Global Hlth Agnes Vans Univ Chair Sci & Soc, New England Reg Biosafety Lab,Cummings Sch Vet Me, North Grafton, MA 01536 USA. EM saul.tzipori@tufts.edu FU NIAID under Food and Waterborne Diseases Integrated Research Network [N01AI30050]; Military Infectious Diseases Program (MIDRP) of the Department of U.S. Army at WRAIR FX Research in the laboratory of ST was supported by a NIAID grant N01AI30050 under the Food and Waterborne Diseases Integrated Research Network. Research in the laboratory of MMV and SB was supported by funding from the Military Infectious Diseases Program (MIDRP) of the Department of U.S. Army at WRAIR. KIJ carried out the experiments in GB piglets and also helped write the manuscript, MMV and SB constructed the mutants, contributed to designing the experiments and writing the mansucript, ST contributed to designing and supervising the experiments and writing the manuscript. The technical assistance of the gnobiotic pig unit (Patty Boucher, Rachel Sora and Donald Guorad) are deeply appreciated. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011 edition. NR 23 TC 3 Z9 4 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 20 PY 2013 VL 31 IS 37 BP 4039 EP 4046 DI 10.1016/j.vaccine.2013.04.076 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 218PI UT WOS:000324444200041 PM 23684833 ER PT J AU Stanley, JK Perkins, EJ Habib, T Sims, JG Chappell, P Escalon, BL Wilbanks, M Garcia-Reyero, N AF Stanley, Jacob K. Perkins, Edward J. Habib, Tanwir Sims, Jerre G. Chappell, Pornsawan Escalon, B. Lynn Wilbanks, Mitchell Garcia-Reyero, Natalia TI The Good, the Bad, and the Toxic: Approaching Hormesis in Daphnia magna Exposed to an Energetic Compound SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NITRIC-OXIDE SYNTHASE; CRUSTACEAN DAPHNIA; PHOSPHATIDIC-ACID; GENE-EXPRESSION; ENCHYTRAEUS-CRYPTICUS; STRESS RESPONSES; MEMBRANE-LIPIDS; SKELETAL-MUSCLE; PHOSPHOLIPASE-D; RISK-ASSESSMENT AB A hormetic response is characterized by an opposite effect in small and large doses of chemical exposure, often resulting in seemingly beneficial effects at low doses. Here, we examined the potential mechanisms underlying the hormetic response of Daphnia magna to the energetic trinitrotoluene (TNT). Daphnia magna were exposed to TNT for 21 days, and a significant increase in adult length and number of neonates was identified at low concentrations (0.002-0.22 mg/L TNT), while toxic effects were identified at high concentrations (0.97 mg/L TNT and above). Microarray analysis of D. magna exposed to 0.004, 0.12, and 1.85 mg/L TNT identified effects on lipid metabolism as a potential mechanism underlying hormetic effects. Lipidomic analysis of exposed D. magna supported the hypothesis that TNT exposure affected lipid and fatty acid metabolism, showing that hormetic effects could be related to changes in polyunsaturated fatty acids known to be involved in Daphnia growth and reproduction. Our results show that Daphnia exposed to low levels of TNT presented hormetic growth and reproduction enhancement, while higher TNT concentrations had an opposite effect. Our results also show how a systems approach can help elucidate potential mechanisms of action and adverse outcomes. C1 [Stanley, Jacob K.; Perkins, Edward J.; Sims, Jerre G.; Escalon, B. Lynn; Wilbanks, Mitchell] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Habib, Tanwir; Chappell, Pornsawan] Badger Tech Serv, San Antonio, TX 78216 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. RP Garcia-Reyero, N (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. EM nvinas@igbb.msstate.edu FU NSF [MCB 0455318, 0920663, DBI 0521587]; NSF EPSCoR [EPS-0236913]; KINBRE (NIH) [P20 RR16475]; US Army Environmental Quality Research Program [BAA 11-4838] FX Lipid analysis was performed at the Kansas Lipidomics Research Center (KLRC) supported by NSF grants MCB 0455318 and 0920663 and DBI 0521587 and NSF EPSCoR grant EPS-0236913 with matching support from the State of Kansas through Kansas Technology Enterprise Corporation and Kansas State University. The KLRC is also supported by KINBRE (NIH Grant P20 RR16475). The authors would like to thank Drs. Mary Roth and Ruth Welti for advise on lipidomics data interpretation. This work was funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. NR 51 TC 8 Z9 8 U1 2 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 20 PY 2013 VL 47 IS 16 BP 9424 EP 9433 DI 10.1021/es401115q PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 205VA UT WOS:000323471700053 PM 23898970 ER PT J AU Campos, B Garcia-Reyero, N Rivetti, C Escalon, L Habib, T Tauler, R Tsakovski, S Pina, B Barata, C AF Campos, Bruno Garcia-Reyero, Natalia Rivetti, Claudia Escalon, Lynn Habib, Tanwir Tauler, Roma Tsakovski, Stefan Pina, Benjamin Barata, Carlos TI Identification of Metabolic Pathways in Daphnia magna Explaining Hormetic Effects of Selective Serotonin Reuptake Inhibitors and 4-Nonylphenol Using Transcriptomic and Phenotypic Responses SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ADVERSE OUTCOME PATHWAYS; BIOMARKER DISCOVERY; RISK-ASSESSMENT; WASTE-WATER; EXPRESSION; PHARMACEUTICALS; TOXICITY; EXPOSURE; STRAUS; ECOTOXICOGENOMICS AB The molecular mechanisms explaining hormetic effects of selective serotonin reuptake inhibitors (SSRIs) and 4-nonylphenol in Daphnia magna reproduction were studied in juveniles and adults. Transcriptome analyses showed changes in mRNA levels for 1796 genes in juveniles and 1214 genes in adults (out of 15 000 total probes) exposed to two SSRIs (fluoxetine and fluvoxamine) or to 4-nonylphenol. Functional annotation of affected genes was improved by assuming the annotations of putatively homologous Drosophila genes. Self-organizing map analysis and partial least-square regression coupled with selectivity ratio procedures analyses allowed to define groups of genes with specific responses to the different treatments. Differentially expressed genes were analyzed for functional enrichment using Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes databases. Serotonin metabolism, neuronal developmental processes, and carbohydrates and lipid metabolism functional categories appeared as selectively affected by SSRI treatment, whereas 4-nonylphenol deregulated genes from the carbohydrate metabolism and the ecdysone regulatory pathway. These changes in functional and metabolic pathways are consistent with previously reported SSRIs and 4-nonylphenol hormetic effects in D. magna, including a decrease in reserve carbohydrates and an increase in respiratory metabolism. C1 [Campos, Bruno; Rivetti, Claudia; Tauler, Roma; Pina, Benjamin; Barata, Carlos] Inst Environm Assessment & Water Res IDAEA CSIC, Barcelona 08034, Spain. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Escalon, Lynn] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Tsakovski, Stefan] Univ Sofia, Fac Chem, Dept Analyt Chem, Sofia 1164, Bulgaria. RP Barata, C (reprint author), Inst Environm Assessment & Water Res IDAEA CSIC, Jordi Girona 18, Barcelona 08034, Spain. EM cbmqam@cid.csic.es RI Pina, Benjamin/A-1671-2011; Barata, Carlos/K-8232-2014; Campos, Bruno/K-9213-2014; Rivetti, Claudia/L-1105-2014 OI Pina, Benjamin/0000-0001-9216-2768; Barata, Carlos/0000-0002-3360-0729; Campos, Bruno/0000-0002-3701-4858; Rivetti, Claudia/0000-0002-8801-0718 FU Spanish MICINN [CGL2008-01898/BOS, CTM2011-30471-C02-01]; MICINN [FPI BES-2009-022741]; U.S. Army Environmental Quality Research Program [BAA 11-4838]; [ERC-2012-AdG-320737] FX This work was supported by the Spanish MICINN grants (CGL2008-01898/BOS and CTM2011-30471-C02-01) and by the Advance Grant ERC-2012-AdG-320737. B.C. was supported by a fellowship from the MICINN (FPI BES-2009-022741). This work was also partly funded by the U.S. Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. NR 49 TC 21 Z9 21 U1 7 U2 56 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 20 PY 2013 VL 47 IS 16 BP 9434 EP 9443 DI 10.1021/es4012299 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 205VA UT WOS:000323471700054 PM 23855649 ER PT J AU Malish, RG Czech, RL Cole, DW AF Malish, Richard G. Czech, Robert L. Cole, David W. TI Screening for and Treatment of Suicide Risk Relevant to Primary Care SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 [Malish, Richard G.] US Army Med Act Ft Stewart, Ft Stewart, GA USA. [Czech, Robert L.; Cole, David W.] USA, Infantry Div 3, Ft Stewart, GA USA. RP Malish, RG (reprint author), US Army Med Act Ft Stewart, Ft Stewart, GA USA. NR 3 TC 0 Z9 0 U1 2 U2 2 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD AUG 20 PY 2013 VL 159 IS 4 BP 307 EP 307 DI 10.7326/0003-4819-159-4-201308200-00019 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 205DM UT WOS:000323421700027 PM 24026267 ER PT J AU Yang, RT Daigle, BJ Muhie, SY Hammamieh, R Jett, M Petzold, L Doyle, FJ AF Yang, Ruoting Daigle, Bernie J., Jr. Muhie, Seid Y. Hammamieh, Rasha Jett, Marti Petzold, Linda Doyle, Francis J., III TI Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder SO BMC SYSTEMS BIOLOGY LA English DT Article ID GENE-COEXPRESSION NETWORK; BREAST-CANCER METASTASIS; PERIPHERAL-BLOOD; EXPRESSION PROFILES; DISEASE; PATHWAY; SUSCEPTIBILITY; IDENTIFICATION; DEPRESSION; DISCOVERY AB Background: Post-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects a substantial portion of combat veterans and poses serious consequences to long-term health. Consequently, the identification of diagnostic and prognostic blood biomarkers for PTSD is of great interest. Previously, we assessed genome-wide gene expression of seven brain regions and whole blood in a social defeat mouse model subjected to various stress conditions. Results: To extract biological insights from these data, we have applied a new computational framework for identifying gene modules that are activated in common across blood and various brain regions. Our results, in the form of modular gene networks that highlight spatial and temporal biological functions, provide a systems-level molecular description of response to social stress. Specifically, the common modules discovered between the brain and blood emphasizes molecular transporters in the blood-brain barrier, and the associated genes have significant overlaps with known blood signatures for PTSD, major depression, and bipolar disease. Similarly, the common modules specific to the brain highlight the components of the social defeat stress response (e.g., fear conditioning pathways) in each brain sub-region. Conclusions: Many of the brain-specific genes discovered are consistent with previous independent studies of PTSD or other mental illnesses. The results from this study further our understanding of the mechanism of stress response and contribute to a growing list of diagnostic biomarkers for PTSD. C1 [Yang, Ruoting; Petzold, Linda; Doyle, Francis J., III] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. [Daigle, Bernie J., Jr.; Petzold, Linda] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA. [Petzold, Linda] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA. [Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Yang, Ruoting; Muhie, Seid Y.; Hammamieh, Rasha; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Yang, Ruoting] Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Frederick, MD 21702 USA. RP Doyle, FJ (reprint author), Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. EM doyle@engineering.ucsb.edu FU U.S. Army Research Office (PTSD) [W911NF-10-2-0111] FX We gratefully acknowledge financial support from U.S. Army Research Office (PTSD Grant W911NF-10-2-0111). We also thank the SysBiocube team, Uma Mudunuri, Sudhir Chowbina, and Raina Kumar, for providing secure data depository system. NR 56 TC 6 Z9 6 U1 1 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD AUG 20 PY 2013 VL 7 AR 80 DI 10.1186/1752-0509-7-80 PG 12 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 204TH UT WOS:000323391800001 PM 23962043 ER PT J AU Wei, Q Kecskes, LJ Ramesh, KT AF Wei, Q. Kecskes, L. J. Ramesh, K. T. TI Effect of low-temperature rolling on the propensity to adiabatic shear banding of commercial purity tungsten SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Rolling; Adiabatic shear banding; Tungsten ID ENERGY PENETRATOR MATERIALS; STRAIN-RATE SENSITIVITY; ULTRAFINE GRAIN SIZES; MECHANICAL-PROPERTIES; REFRACTORY-METALS; MICROSTRUCTURAL EVOLUTION; POLYCRYSTALLINE TUNGSTEN; PLASTIC-DEFORMATION; LOCALIZATION THEORY; FLOW LOCALIZATION AB In this work, we have investigated the effect of low-temperature rolling on the mechanical properties of commercial purity tungsten, particularly the high strain rate (dynamic) behavior of the cold-rolled samples vis-a-vis the as-received coarse-grained material. After rolling, the material was tested under both quasi-static and dynamic (Kolsky bar) uniaxial compression loading conditions. We have found that low-temperature rolling both improves the ductility and the strength of commercial purity tungsten. The rolled tungsten exhibits elastic-nearly perfectly plastic behavior under quasi-static loading, and a strong flow softening tendency with a precipitous stress drop under dynamic loading. Both in situ high speed movie snapshots and post-mortem examination of the dynamic samples suggest that the precipitous stress drop was caused by adiabatic shear banding in the cold-rolled material. The greatly enhanced susceptibility to adiabatic shear banding in the cold-rolled tungsten can either be explained semi-quantitatively based on a mechanistic model or from the rolling texture that leads to geometric softening under dynamic loading. (C) 2013 Elsevier B.V. All rights reserved. C1 [Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Kecskes, L. J.] USA, WMRD, Res Lab, Aberdeen, MD 21005 USA. [Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 FU US Army Research Laboratory [DAAD19-01-2-0003] FX The majority of the experimental work was performed at the Center for Advanced Ceramic and Metallic Systems (CAMCS) at the Johns Hopkins University under the auspices of the US Army Research Laboratory under contract number #DAAD19-01-2-0003. Discussions with Drs. Ma, Magness, Schuster, and Dowding are appreciated. The authors would like to thank Dr. Jiao for assistance in the high strain rate experiments. NR 65 TC 13 Z9 13 U1 4 U2 33 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD AUG 20 PY 2013 VL 578 BP 394 EP 401 DI 10.1016/j.msea.2013.04.109 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 180LA UT WOS:000321595500052 ER PT J AU Verba, R Tiberkevich, V Bankowski, E Meitzler, T Melkov, G Slavin, A AF Verba, Roman Tiberkevich, Vasil Bankowski, Elena Meitzler, Thomas Melkov, Gennadiy Slavin, Andrei TI Conditions for the spin wave nonreciprocity in an array of dipolarly coupled magnetic nanopillars SO APPLIED PHYSICS LETTERS LA English DT Article AB It is demonstrated that collective spin waves (SWs) propagating in complex periodic arrays of dipolarly coupled magnetic nanopillars existing in a saturated (single-domain) ground state in a zero bias magnetic field could be nonreciprocal. To guarantee the SW nonreciprocity, two conditions should be fulfilled: (i) existence of a nonzero out-of-plane component of the pillars' static magnetization and (ii) a complex periodicity of array's ground state with at least two elements per a primitive cell, if the elements are different, and at least three elements per a primitive cell, if the elements are identical. (C) 2013 AIP Publishing LLC. C1 [Verba, Roman; Melkov, Gennadiy] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. [Tiberkevich, Vasil; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA. RP Verba, R (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. EM verrv@ukr.net RI Tiberkevich, Vasil/A-8697-2008; Verba, Roman/J-4452-2014; Meitzler, Thomas/D-1065-2017 OI Tiberkevich, Vasil/0000-0002-8374-2565; Verba, Roman/0000-0001-8811-6232; FU NSF of the USA [DMR-1015175]; U.S. Army TARDEC, RDECOM; DARPA MTO/MESO Grant [N66001-11-1-4114]; CNFD grant from the Semiconductor Research Corporation; MES of Ukraine [M/90-2010]; SFFR (DFFD) of Ukraine [UU34/008] FX This work was supported in part by the Grant No. DMR-1015175 from the NSF of the USA, by the Contract from the U.S. Army TARDEC, RDECOM, by the DARPA MTO/MESO Grant No. N66001-11-1-4114, by the CNFD grant from the Semiconductor Research Corporation, by the Grant No. M/90-2010 from the MES of Ukraine, and by the Grant No. UU34/008 from the SFFR (DFFD) of Ukraine. NR 21 TC 21 Z9 21 U1 2 U2 32 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 19 PY 2013 VL 103 IS 8 AR 082407 DI 10.1063/1.4819435 PG 5 WC Physics, Applied SC Physics GA 209VH UT WOS:000323788100050 ER PT J AU Dortch, MS Johnson, BE Gerald, JA AF Dortch, Mark S. Johnson, Billy E. Gerald, Jeffrey A. TI Modeling Fate and Transport of Munitions Constituents on Firing Ranges SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE TREECS; soil; vadose zone; groundwater; surface water; fate and transport models ID SOIL; RDX AB The Training Range Environmental Evaluation and Characterization System (TREECS) computes the fate and transport of munitions constituents deposited on military firing/training ranges. TREECSTM was developed with two levels of capability, Tiers 1 and 2, where Tier 1 is for conservative screening assessments, and Tier 2 is for more accurate predictions. The models and associated processes for Tier 2 are described. Tier 2 was applied to ranges at Fort A.P. Hill, VA, for initial demonstration purposes. Observed field data were provided after model application and are compared to model-computed results. Although the comparison was not sufficient for model validation, it does demonstrate that the model leads to the same general conclusions that the field data provided. C1 [Dortch, Mark S.] Los Alamos Tech Associates, Los Alamos, NM USA. [Johnson, Billy E.; Gerald, Jeffrey A.] USA, ERDC, Vicksburg, MS USA. RP Dortch, MS (reprint author), ERDC EP W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Mark.S.Dortch@usace.army.mil NR 27 TC 1 Z9 1 U1 5 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PD AUG 18 PY 2013 VL 22 IS 6 BP 667 EP 688 DI 10.1080/15320383.2013.756453 PG 22 WC Environmental Sciences SC Environmental Sciences & Ecology GA 137AG UT WOS:000318406100006 ER PT J AU Mizanur, RM Frasca, V Swaminathan, S Bavari, S Webb, R Smith, LA Ahmed, SA AF Mizanur, Rahman M. Frasca, Verna Swaminathan, Subramanyam Bavari, Sina Webb, Robert Smith, Leonard A. Ahmed, S. Ashraf TI The C Terminus of the Catalytic Domain of Type A Botulinum Neurotoxin May Facilitate Product Release from the Active Site SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID TO-STRUCTURE PIPELINE; LIGHT-CHAIN; SUBSTRATE RECOGNITION; TRYPTOPHAN SYNTHASE; SEROTYPE-A; N-TERMINUS; PROTEOLYTIC ACTIVITY; CRYSTAL-STRUCTURE; PROTEASE ACTIVITY; IDENTIFICATION AB Botulinum neurotoxins are the most toxic of all compounds. The toxicity is related to a poor zinc endopeptidase activity located in a 50-kDa domain known as light chain (Lc) of the toxin. The C-terminal tail of Lc is not visible in any of the currently available x-ray structures, and it has no known function but undergoes autocatalytic truncations during purification and storage. By synthesizing C-terminal peptides of various lengths, in this study, we have shown that these peptides competitively inhibit the normal catalytic activity of Lc of serotypeA(LcA) and have defined the length of the mature LcA to consist of the first 444 residues. Two catalytically inactive mutants also inhibited LcA activity. Our results suggested that the C terminus of LcA might interact at or near its own active site. By using synthetic C-terminal peptides from LcB, LcC1, LcD, LcE, and LcF and their respective substrate peptides, we have shown that the inhibition of activity is specific only for LcA. Although a potent inhibitor with a K-i of 4.5 mu M, the largest of our LcA C-terminal peptides stimulated LcA activity when added at near-stoichiometric concentration to three versions of LcA differing in their C-terminal lengths. The result suggested a product removal role of the LcA C terminus. This suggestion is supported by a weak but specific interaction determined by isothermal titration calorimetry between an LcA C-terminal peptide and N-terminal product from a peptide substrate of LcA. Our results also underscore the importance of using a mature LcA as an inhibitor screening target. C1 [Mizanur, Rahman M.; Bavari, Sina; Webb, Robert; Ahmed, S. Ashraf] US Army, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Frasca, Verna] GE Healthcare Life Sci, Northampton, MA 01060 USA. [Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Smith, Leonard A.] Off Chief Scientist, Ft Detrick, MD 20854 USA. RP Ahmed, SA (reprint author), US Army, Integrated Toxicol Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM syed.ahmed@amedd.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense Grant [JSTOCBD3.10012_06_RD_B]; National Research Council FX This work was supported in part by Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense Grant JSTOCBD3.10012_06_RD_B (to S. A. A.).; Supported by the National Research Council through the research associateship program. NR 48 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD AUG 16 PY 2013 VL 288 IS 33 BP 24223 EP 24233 DI 10.1074/jbc.M113.451286 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 302NO UT WOS:000330611400060 PM 23779108 ER PT J AU Bergmann-Leitner, ES Chaudhury, S Steers, NJ Sabato, M Delvecchio, V Wallqvist, AS Ockenhouse, CF Angov, E AF Bergmann-Leitner, Elke S. Chaudhury, Sidhartha Steers, Nicholas J. Sabato, Mark Delvecchio, Vito Wallqvist, Anders S. Ockenhouse, Christian F. Angov, Evelina TI Computational and Experimental Validation of B and T-Cell Epitopes of the In Vivo Immune Response to a Novel Malarial Antigen SO PLOS ONE LA English DT Article ID STRUCTURE PREDICTION; PROTEIN ANTIGENS; BINDING; CELTOS; SERVER; PROTECTION; PROFILES; VACCINES; ROSETTA; REGIONS AB Vaccine development efforts will be guided by algorithms that predict immunogenic epitopes. Such prediction methods rely on classification-based algorithms that are trained against curated data sets of known B and T cell epitopes. It is unclear whether this empirical approach can be applied prospectively to predict epitopes associated with protective immunity for novel antigens. We present a comprehensive comparison of in silico B and T cell epitope predictions with in vivo validation using an previously uncharacterized malaria antigen, CelTOS. CelTOS has no known conserved structural elements with any known proteins, and thus is not represented in any epitope databases used to train prediction algorithms. This analysis represents a blind assessment of this approach in the context of a novel, immunologically relevant antigen. The limited accuracy of the tested algorithms to predict the in vivo immune responses emphasizes the need to improve their predictive capabilities for use as tools in vaccine design. C1 [Bergmann-Leitner, Elke S.; Ockenhouse, Christian F.; Angov, Evelina] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Steers, Nicholas J.] US Mil HIV Res Program, Div Retrovirol, Silver Spring, MD USA. [Chaudhury, Sidhartha; Wallqvist, Anders S.] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Sabato, Mark; Delvecchio, Vito] Vital Probes Inc, Mayfield, PA USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Vaccine Program, Silver Spring, MD USA. EM Elke.S.BergmannLeitner.ctr@mail.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Agency for International Development [936-3118, GHA-T-00-08-00007-01]; United States Army Medical Research and Materiel Command FX This work was supported by the U.S. Agency for International Development under project number 936-3118, award number GHA-T-00-08-00007-01, and by the United States Army Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 13 Z9 13 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 16 PY 2013 VL 8 IS 8 AR e71610 DI 10.1371/journal.pone.0071610 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 207BA UT WOS:000323570200036 PM 23977087 ER PT J AU Krueger, WS Khuntirat, B Yoon, IK Blair, PJ Chittagarnpitch, M Putnam, SD Supawat, K Gibbons, RV Bhuddari, D Pattamadilok, S Sawanpanyalert, P Heil, GL Gray, GC AF Krueger, Whitney S. Khuntirat, Benjawan Yoon, In-Kyu Blair, Patrick J. Chittagarnpitch, Malinee Putnam, Shannon D. Supawat, Krongkaew Gibbons, Robert V. Bhuddari, Darunee Pattamadilok, Sirima Sawanpanyalert, Pathom Heil, Gary L. Gray, Gregory C. TI Prospective Study of Avian Influenza Virus Infections among Rural Thai Villagers SO PLOS ONE LA English DT Article ID A H5N1 VIRUS; SWINE WORKERS; UNITED-STATES; SURVEILLANCE; PNEUMONIA; OUTBREAKS; POULTRY; ASSAYS; RISK; PCR AB Background: In 2008, 800 rural Thai adults living within Kamphaeng Phet Province were enrolled in a prospective cohort study of zoonotic influenza transmission. Serological analyses of enrollment sera suggested this cohort had experienced subclinical avian influenza virus (AIV) infections with H9N2 and H5N1 viruses. Methods: After enrollment, participants were contacted weekly for 24mos for acute influenza-like illnesses (ILI). Cohort members confirmed to have influenza A infections were enrolled with their household contacts in a family transmission study involving paired sera and respiratory swab collections. Cohort members also provided sera at 12 and 24 months after enrollment. Serologic and real-time RT-PCR assays were performed against avian, swine, and human influenza viruses. Results: Over the 2 yrs of follow-up, 81 ILI investigations in the cohort were conducted; 31 (38%) were identified as influenza A infections by qRT-PCR. Eighty-three household contacts were enrolled; 12 (14%) reported ILIs, and 11 (92%) of those were identified as influenza infections. A number of subjects were found to have slightly elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2) virus: 21 subjects (2.7%) at 12-months and 40 subjects (5.1%) at 24-months. Among these, two largely asymptomatic acute infections with H9N2 virus were detected by >4-fold increases in annual serologic titers (final titers 1: 80). While controlling for age and influenza vaccine receipt, moderate poultry exposure was significantly associated with elevated H9N2 titers (adjusted OR = 2.3; 95% CI, 1.04-5.2) at the 24-month encounter. One subject had an elevated titer (1: 20) against H5N1 during follow-up. Conclusions: From 2008-10, evidence for AIV infections was sparse among this rural population. Subclinical H9N2 AIV infections likely occurred, but serological results were confounded by antibody cross-reactions. There is a critical need for improved serological diagnostics to more accurately detect subclinical AIV infections in humans. C1 [Krueger, Whitney S.; Heil, Gary L.; Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32610 USA. [Krueger, Whitney S.; Heil, Gary L.; Gray, Gregory C.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA. [Khuntirat, Benjawan; Yoon, In-Kyu; Gibbons, Robert V.; Bhuddari, Darunee] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Blair, Patrick J.] Naval Med Res Unit 2, Singapore, Singapore. [Blair, Patrick J.] Off Def Cooperat, Singapore, Singapore. [Chittagarnpitch, Malinee; Supawat, Krongkaew; Pattamadilok, Sirima; Sawanpanyalert, Pathom] Minist Publ Hlth, Natl Inst Hlth, Bangkok, Thailand. [Putnam, Shannon D.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Gray, GC (reprint author), Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32610 USA. EM gcgray@phhp.ufl.edu FU US Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance Operations; National Institute of Allergy and Infectious Diseases [R01 AI068803] FX This work was supported by the US Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance Operations (multiple grants to GCG, PJB, SDP, and IU) and National Institute of Allergy and Infectious Diseases (R01 AI068803 to GCG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 9 Z9 9 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 16 PY 2013 VL 8 IS 8 AR e72196 DI 10.1371/journal.pone.0072196 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 207BA UT WOS:000323570200063 PM 23977250 ER PT J AU Reine, K Clarke, D Ray, G Dickerson, C AF Reine, Kevin Clarke, Douglas Ray, Gary Dickerson, Charles TI Fishery resource utilization of a restored estuarine borrow pit: A beneficial use of dredged material case study SO MARINE POLLUTION BULLETIN LA English DT Article DE Fisheries hydroacoustics; Benthos; Essential fish habitat; Borrow sites; Habitat restoration ID BAY; WATERS AB Numerous pits in coastal waters are subject to degraded water quality and benthic habitat conditions, resulting in degraded fish habitat. A pit in Barnegat Bay, New jersey (USA) was partially filled with dredged sediment to increase flushing, alleviate hypoxia, and enhance benthic assemblages. Restoration objectives were assessed in terms of benthic community parameters and fishery resource occupation. Restoration resulted in increased benthic diversity (bottom samples) and the absence of water column stratification. Fisheries resources occupied the entire water column, unlike pre-restoration conditions where finfish tended to avoid the lower water column. The partial restoration option effectively reproduced an existing borrow pit configuration (Hole #5, control), by decreasing total depth from 11 m to -5.5 m, thereby creating a habitat less susceptible to hypoxic/anoxic conditions, while retaining sufficient vertical relief to maintain associations with juvenile weakfish and other forage fishes. Partially filling pits using dredged material represents a viable restoration alternative. Published by Elsevier Ltd. C1 [Reine, Kevin; Clarke, Douglas; Ray, Gary] US Army, Engn Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, Vicksburg, MS 39180 USA. [Dickerson, Charles] Bowhead Informat Technol Serv, Vicksburg, MS 39180 USA. RP Reine, K (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM KevinJ.Reine@usace.army.mil FU Environmental Focus Area of the Dredging Operations and Environmental Research (DOER) Program FX The study was funded by the Environmental Focus Area of the Dredging Operations and Environmental Research (DOER) Program. The Program Manager is Dr. Todd Bridges. The sponsor had no involvement in the study design, in the collection, analysis and interpretation of the data or in the writing of the report. The sponsor (Program Manager) has encouraged peer-reviewed publication of studies conducted under the DOER Program, but did choose or influence the journal selected for publication. NR 40 TC 3 Z9 3 U1 0 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD AUG 15 PY 2013 VL 73 IS 1 BP 115 EP 128 DI 10.1016/j.marpolbul.2013.05.031 PG 14 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 207GM UT WOS:000323586900027 PM 23790449 ER PT J AU Vasilyev, A Petersen, E Satyan, N Rakuljic, G Yariv, A White, JO AF Vasilyev, Arseny Petersen, Eliot Satyan, Naresh Rakuljic, George Yariv, Amnon White, Jeffrey Owen TI Coherent Power Combining of Chirped-Seed Erbium-Doped Fiber Amplifiers SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE Optical phase locked loops; stimulated Brillouin scattering; Erbium-doped fiber amplifier; phase control ID STIMULATED BRILLOUIN-SCATTERING; OPTICAL-FIBERS; SBS-THRESHOLD; PHASE; LOCKING AB Using a rapidly-chirped (5 x 10(14) Hz/s) continuous-wave optoelectronic swept-frequency seed laser and two 3 W erbium-doped fiber amplifiers, we demonstrate simultaneous stimulated Brillouin scattering suppression, coherent power combining, and electronic beam steering, without imposing strict path-length matching requirements. Our platform presents a viable path toward high-power continuous-wave sources. C1 [Vasilyev, Arseny; Satyan, Naresh; Yariv, Amnon] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Petersen, Eliot; White, Jeffrey Owen] US Army Res Lab, Adelphi, MD 20783 USA. [Rakuljic, George] Telaris Inc, Santa Monica, CA 90403 USA. RP Vasilyev, A (reprint author), CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. EM vasilyev@caltech.edu; eliot.petersen.ctr@mail.mil; naresh@caltech.edu; rakuljic@telarisinc.com; ayariv@caltech.edu; jeffrey.o.white6.civ@mail.mil FU U.S. Army Research Office [W911NF-11-2-0081]; High Energy Laser Joint Technology Office [11-SA-0405] FX This work was supported in part by the U.S. Army Research Office under Grant W911NF-11-2-0081 and in part by the High Energy Laser Joint Technology Office under Grant 11-SA-0405. NR 12 TC 6 Z9 6 U1 2 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD AUG 15 PY 2013 VL 25 IS 16 BP 1616 EP 1618 DI 10.1109/LPT.2013.2271784 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 195PE UT WOS:000322714900011 ER PT J AU Khedir, KR Kannarpady, GK Ishihara, H Woo, J Asar, MP Ryerson, C Biris, AS AF Khedir, Khedir R. Kannarpady, Ganesh K. Ishihara, Hidetaka Woo, Justin Asar, Madhu P. Ryerson, Charles Biris, Alexandru S. TI Temperature-dependent bouncing of super-cooled water on teflon-coated superhydrophobic tungsten nanorods SO APPLIED SURFACE SCIENCE LA English DT Article DE Bouncing phenomenon; Supercooled water droplet; Superhydrophobicity; Tungsten nanorods ID ICE ADHESION; SUPERCOOLED WATER; SURFACES; IMPACT; DROPLETS; COATINGS; HYDROPHOBICITY; ICEPHOBICITY; TRANSITIONS; PERFORMANCE AB The bouncing mechanism of warm and supercooled water droplets with temperatures ranging from 20 degrees C to -10 degrees C on the surface of superhydrophobic (SHP) tungsten nanorods (WNRs), held at a constant temperature of -10 degrees C, was investigated. The measurements were carried out inside a chamber kept at a low relative humidity of 20%. A considerable energy loss was observed mainly due to the increase in the viscous forces of the supercooled water droplet. The increase in the values of the capillary number, as a result of the variation in both viscosity and surface energy of the supercooled water droplet, has confirmed the significant role of viscous forces in the dissipation of bouncing energy. However, the contact time and contact line evolution of the supercooled water droplet on the surface remained unaffected by the decrease in its temperature at constant humidity. The calculations of the bouncing restitution and dissipated energy at various water droplet temperatures, using classical mechanics, were also carried out. (C) 2013 Elsevier B.V. All rights reserved. C1 [Khedir, Khedir R.; Kannarpady, Ganesh K.; Ishihara, Hidetaka; Woo, Justin; Asar, Madhu P.; Biris, Alexandru S.] Univ Arkansas, Ctr Integrat Nanotechnol Sci, Little Rock, AR 72204 USA. [Ryerson, Charles] US Army Corps Engineers, Terr & Cryospher Sci Branch Cold Reg, Res & Engn Lab, Hanover, NH 03755 USA. RP Biris, AS (reprint author), Univ Arkansas, Ctr Integrat Nanotechnol Sci, 2801 South Univ Ave, Little Rock, AR 72204 USA. EM asbiris@ualr.edu FU U.S. Army (ERDC) [W912HZ-09-02-0008]; Arkansas Science & Technology Authority [08-CAT-03]; Department of Energy [DE-FG36-06GO86072]; National Science Foundation [NSF/EPS-1003970] FX Financial support from the U.S. Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008), the Arkansas Science & Technology Authority (Grant # 08-CAT-03), and the Department of Energy (DE-FG36-06GO86072) and National Science Foundation (NSF/EPS-1003970) is greatly appreciated. The editorial assistance of Dr. Marinelle Ringer is also acknowledged. NR 59 TC 10 Z9 10 U1 2 U2 58 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD AUG 15 PY 2013 VL 279 BP 76 EP 84 DI 10.1016/j.apsusc.2013.04.038 PG 9 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA 169GB UT WOS:000320766500013 ER PT J AU Uchimiya, M Bannon, DI AF Uchimiya, Minori Bannon, Desmond I. TI Solubility of Lead and Copper in Biochar-Amended Small Arms Range Soils: Influence of Soil Organic Carbon and pH SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE surface complexation; remediation; agricultural waste; thermochemical conversion; biomass ID PYROLYSIS TEMPERATURE; FUNCTIONAL-GROUPS; BIOMASS; IMMOBILIZATION; RETENTION; CHARCOAL; DESORPTION; TRANSPORT; MOBILITY; BEHAVIOR AB Biochar is often considered a strong heavy metal stabilizing agent. However, biochar in some cases had no effects on, or increased the soluble concentrations of, heavy metals in soil. The objective of this study was to determine the factors causing some biochars to stabilize and others to dissolve heavy metals in soil. Seven small arms range soils with known total organic carbon (TOC), cation exchange capacity, pH, and total Pb and Cu contents were first screened for soluble Pb and Cu concentrations. Over 2 weeks successive equilibrations using weak acid (pH 4.5 sulfuric acid) and acetate buffer (0.1 M at pH 4.9), Alaska soil containing disproportionately high (31.6%) TOC had nearly 100% residual (insoluble) Pb and Cu. This soil was then compared with sandy soils from Maryland containing significantly lower (0.5-2.0%) TOC in the presence of 10 wt 96 (i) plant biochar activated to increase the surface-bound carboxyl and phosphate ligands (PS450A), (ii) manure biochar enriched with soluble P (BL700), and (iii) unactivated plant biochars produced at 350 degrees C (CH350) and 700 degrees C (CH500) and by flash carbonization (corn). In weak acid, the pH was set by soil and biochar, and the biochars increasingly stabilized Pb with repeated extractions. In pH 4.9 acetate buffer, PS450A and BL700 stabilized Pb, and only PS450A stabilized Cu. Surface ligands of PS450A likely complexed and stabilized Pb and Cu even under acidic pH in the presence of competing acetate ligand. Oppositely, unactivated plant biochars (CH350, CH500, and corn) mobilized Pb and Cu in sandy soils; the putative mechanism is the formation of soluble complexes with biochar-borne dissolved organic carbon. In summary, unactivated plant biochars can inadvertently increase dissolved Pb and Cu concentrations of sandy, low TOC soils when used to stabilize other contaminants. C1 [Uchimiya, Minori] ARS, So Reg Res Ctr, USDA, New Orleans, LA 70124 USA. [Bannon, Desmond I.] US Army Publ Hlth Command, Army Inst Publ Hlth, Toxicol Portfolio, Aberdeen Proving Ground, MD 21010 USA. RP Uchimiya, M (reprint author), ARS, So Reg Res Ctr, USDA, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov NR 44 TC 14 Z9 18 U1 5 U2 142 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD AUG 14 PY 2013 VL 61 IS 32 BP 7679 EP 7688 DI 10.1021/jf401481x PG 10 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 202SV UT WOS:000323240800003 PM 23869882 ER PT J AU Moncunill, G Mayor, A Jimenez, A Nhabomba, A Casas-Vila, N Puyol, L Campo, JJ Manaca, MN Aguilar, R Pinazo, MJ Almirall, M Soler, C Munoz, J Bardaji, A Angov, E Dutta, S Chitnis, CE Alonso, PL Gascon, J Dobano, C AF Moncunill, Gemma Mayor, Alfredo Jimenez, Alfons Nhabomba, Augusto Casas-Vila, Nuria Puyol, Laura Campo, Joseph J. Manaca, Maria Nelia Aguilar, Ruth Pinazo, Maria-Jesus Almirall, Merce Soler, Cristina Munoz, Jose Bardaji, Azucena Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Alonso, Pedro L. Gascon, Joaquim Dobano, Carlota TI High Antibody Responses against Plasmodium falciparum in Immigrants after Extended Periods of Interrupted Exposure to Malaria SO PLOS ONE LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; INTERMITTENT PREVENTIVE TREATMENT; ERYTHROCYTE-MEMBRANE PROTEIN-1; MOZAMBICAN CHILDREN; ACQUIRED-IMMUNITY; IMPORTED MALARIA; SULFADOXINE-PYRIMETHAMINE; INHIBITORY ANTIBODIES; GHANAIAN CHILDREN; CLINICAL MALARIA AB Background: Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas. Methods: A cross-sectional study was conducted among sub-Saharan African adults residing in Spain for 1 up to 38 years (immigrants) with clinical malaria (n=55) or without malaria (n=37), naive adults (travelers) with a first clinical malaria episode (n=20) and life-long malaria exposed adults from Mozambique (semi-immune adults) without malaria (n=27) or with clinical malaria (n=50). Blood samples were collected and IgG levels against the erythrocytic antigens AMA-1 and MSP-1(42) (3D7 and FVO strains), EBA-175 and DBL-alpha were determined by Luminex. IgG levels against antigens on the surface of infected erythrocytes (IEs) were measured by flow cytometry. Results: Immigrants without malaria had lower IgG levels than healthy semi-immune adults regardless of the antigen tested (P <= 0.026), but no correlation was found between IgG levels and time since migration. Upon reinfection, immigrants with malaria had higher levels of IgG against all antigens than immigrants without malaria. However, the magnitude of the response compared to semi-immune adults with malaria depended on the antigen tested. Thus, immigrants had higher IgG levels against AMA-1 and MSP-1(42) (P <= 0.015), similar levels against EBA-175 and DBL-alpha, and lower levels against IEs (P <= 0.016). Immigrants had higher IgG levels against all antigens tested compared to travelers (P <= 0.001), both with malaria. Conclusions: Upon cessation of malaria exposure, IgG responses to malaria-specific antigens were maintained to a large extent, although the conservation and the magnitude of the recall response depended on the nature of the antigen. Studies on immigrant populations can shed light on the factors that determine the duration of malaria specific antibody responses and its effect on protection, with important implications for future vaccine design and public health control measures. C1 [Moncunill, Gemma; Mayor, Alfredo; Jimenez, Alfons; Casas-Vila, Nuria; Puyol, Laura; Campo, Joseph J.; Aguilar, Ruth; Pinazo, Maria-Jesus; Munoz, Jose; Bardaji, Azucena; Alonso, Pedro L.; Gascon, Joaquim; Dobano, Carlota] Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, Barcelona, Catalonia, Spain. [Mayor, Alfredo; Nhabomba, Augusto; Manaca, Maria Nelia; Aguilar, Ruth; Alonso, Pedro L.; Dobano, Carlota] Ctr Invest Saude Manhica, Maputo, Mozambique. [Almirall, Merce] Hosp Arnau Vilanova, Lleida, Catalonia, Spain. [Soler, Cristina] Hosp Santa Caterina de Salt, Girona, Catalonia, Spain. [Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chitnis, Chetan E.] Int Ctr Genet Engn & Biotechnol ICGEB, New Delhi, India. RP Moncunill, G (reprint author), Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, Barcelona, Catalonia, Spain. EM gemma.moncunill@cresib.cat RI Gascon, Joaquim/M-3598-2015; Dobano, Carlota/N-4119-2014; OI Gascon, Joaquim/0000-0002-5045-1585; Dobano, Carlota/0000-0002-6751-4060; Moncunill, Gemma/0000-0001-5105-9836 FU Ministerio de Ciencia e Innovacion [SAF2008-00743, RYC-2008-02631]; Instituto de Salud Carlos III [PI050275, PS0901113, CD10/00156, CP-4/00220]; Agencia de Gestio d'Ajuts Universitaris i de Recerca [2009SGR934, 2009SGR385, 2010FI_B 00168]; Fundacion Ramon Areces FX The study received financial support from the Ministerio de Ciencia e Innovacion (SAF2008-00743, salary support RYC-2008-02631 to C. D.); the Instituto de Salud Carlos III (PI050275, PS0901113, salary support CD10/00156 to G. M. and CP-4/00220 to A. M.); the Agencia de Gestio d'Ajuts Universitaris i de Recerca (2009SGR934, 2009SGR385, salary support 2010FI_B 00168 to J.C.); and the Fundacion Ramon Areces. The Centro de Investigacao em Sa de de Manhica receives core support from the Spanish Agency for International Cooperation and Development (AECID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 61 TC 13 Z9 13 U1 2 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 14 PY 2013 VL 8 IS 8 AR e73624 DI 10.1371/journal.pone.0073624 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 202MQ UT WOS:000323221500148 PM 23967347 ER PT J AU Nablo, BJ Panchal, RG Bavari, S Nguyen, TL Gussio, R Ribot, W Friedlander, A Chabot, D Reiner, JE Robertson, JWF Balijepalli, A Halverson, KM Kasianowicz, JJ AF Nablo, Brian J. Panchal, Rekha G. Bavari, Sina Nguyen, Tam L. Gussio, Rick Ribot, Wil Friedlander, Art Chabot, Donald Reiner, Joseph E. Robertson, Joseph W. F. Balijepalli, Arvind Halverson, Kelly M. Kasianowicz, John J. TI Anthrax toxin-induced rupture of artificial lipid bilayer membranes SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID SYMMETRICAL TETRAALKYLAMMONIUM IONS; IRREVERSIBLE ELECTRICAL BREAKDOWN; STERIC-BLOCK OLIGONUCLEOTIDES; CELL PENETRATING PEPTIDES; EFFICIENT GENE-TRANSFER; PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; LETHAL FACTOR; PROTEIN TRANSLOCATION; EDEMA FACTOR AB We demonstrate experimentally that anthrax toxin complexes rupture artificial lipid bilayer membranes when isolated from the blood of infected animals. When the solution pH is temporally acidified to mimic that process in endosomes, recombinant anthrax toxin forms an irreversibly bound complex, which also destabilizes membranes. The results suggest an alternative mechanism for the translocation of anthrax toxin into the cytoplasm. C1 [Nablo, Brian J.; Reiner, Joseph E.; Robertson, Joseph W. F.; Balijepalli, Arvind; Kasianowicz, John J.] NIST, Phys Measurement Lab, Gaithersburg, MD 20899 USA. [Panchal, Rekha G.; Bavari, Sina; Ribot, Wil; Friedlander, Art; Chabot, Donald; Halverson, Kelly M.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Nguyen, Tam L.; Gussio, Rick] NCI, Dev Therapeut Program, Target Struct Based Drug Discovery Grp, SAIC, Frederick, MD 21702 USA. [Balijepalli, Arvind] NHLBI, Lab Computat Biol, Rockville, MD 20852 USA. RP Kasianowicz, JJ (reprint author), NIST, Phys Measurement Lab, Gaithersburg, MD 20899 USA. EM john.kasianowicz@nist.gov OI Reiner, Joseph/0000-0002-1056-8703 FU NIST-NRC; NIH-NIST-NRC; NIST Office of Law Enforcement Standards FX This work is supported, in part, by a NIST-NRC Research Associateship (B.J.N.), a NIH-NIST-NRC Research Associateship (A.B.), and the NIST Office of Law Enforcement Standards (J.J.K.). Certain commercial equipment, instruments, or materials are identified in this paper to adequately specify the experimental procedure. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose. In conducting the research described in this paper, the investigators adhered to the "Guide for Care and Use of Laboratory Animals" as promulgated by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council. The facilities are fully accredited by the American Association for Accreditation of Laboratory Animal Care. NR 130 TC 6 Z9 6 U1 3 U2 16 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 14 PY 2013 VL 139 IS 6 AR 065101 DI 10.1063/1.4816467 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 201YB UT WOS:000323177900055 PM 23947891 ER PT J AU Petr, M Kharlampieva, E Cropek, D Grimme, S AF Petr, Michael Kharlampieva, Eugenia Cropek, Donald Grimme, Stephen TI On the Origin of the Major Peak Cluster Spacing in the Mass Spectra of Copolymers SO MACROMOLECULES LA English DT Article ID MALDI-TOF-MS; STRUCTURAL-CHARACTERIZATION; DIBLOCK COPOLYMERS; BIVARIATE DISTRIBUTION; SYNTHETIC-POLYMERS; SPECTROMETRY; LENGTH; POLY(LACTIDE-CO-GLYCOLIDE); POLYSTYRENE; TOPOLOGY AB Mass spectrometry (MS) is a uniquely informative technique in the characterization of copolymers, where spectra prominently feature peak clustering. The spacing of these clusters, in general, is dominated by the spacing of one repeat unit, and contained herein is the theory to explain this observation. Extension of this theory also explains the more subtle observation that, even though the spacing is generally that of one unit, occasionally, the spacing between the maxima of adjacent clusters shifts by that of the other unit. Furthermore, the theory predicts that, in the low molecular weight region of the spectrum, there is a total switch to the spacing of the other unit along with asymmetric peak dusters that have a "sawtooth" shape. The analysis uses the Gaussian, log-normal, and Schulz-Zimm models as well as the random coupling hypothesis to explicitly demonstrate that (1) the major peak cluster spacing naturally arises from the unit in the copolymer with the widest distribution, as measured by the scaled standard deviation, (2) the spacing shift naturally occurs due to the marginal probabilities away from the spectrum maximum, and (3) the low molecular weight switch is a natural consequence of the tail of the distribution of the unit with the widest distribution. Results are provided to predict which unit in the copolymer will govern the major peak cluster spacing, how often the spacing will shift to that of another unit in the middle and high molecular weight regions of the spectrum, the molecular weight and composition of the maximum peak in every cluster, and the molecular weight below which the spacing will be that of the another unit. We believe that our results are the first to provide tangible theory to explain the previously unknown origins of these empirically observed phenomena. C1 [Petr, Michael; Cropek, Donald; Grimme, Stephen] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Kharlampieva, Eugenia] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA. RP Grimme, S (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. EM Stephen.J.Grimme@usace.army.mil FU U.S. Army Engineer Research and Development Center (ERDC); U.S. Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL) FX This research was funded by the U.S. Army Engineer Research and Development Center (ERDC) Research, Development Test and Evaluation (RDT&E) basic research program. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL) administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. NR 30 TC 0 Z9 0 U1 2 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD AUG 13 PY 2013 VL 46 IS 15 BP 6233 EP 6242 DI 10.1021/ma400579y PG 10 WC Polymer Science SC Polymer Science GA 202DI UT WOS:000323193300048 ER PT J AU Shubina, D Cakirli, RB Litvinov, YA Blaum, K Brandau, C Bosch, F Carroll, JJ Casten, RF Cullen, DM Cullen, IJ Deo, AY Detwiler, B Dimopoulou, C Farinon, F Geissel, H Haettner, E Heil, M Kempley, RS Kozhuharov, C Knobel, R Kurcewicz, J Kuzminchuk, N Litvinov, SA Liu, Z Mao, R Nociforo, C Nolden, F Patyk, Z Plass, WR Prochazka, A Reed, MW Sanjari, MS Scheidenberger, C Steck, M Stohlker, T Sun, B Swan, TPD Trees, G Walker, PM Weick, H Winckler, N Winkler, M Woods, PJ Yamaguchi, T Zhou, C AF Shubina, D. Cakirli, R. B. Litvinov, Yu A. Blaum, K. Brandau, C. Bosch, F. Carroll, J. J. Casten, R. F. Cullen, D. M. Cullen, I. J. Deo, A. Y. Detwiler, B. Dimopoulou, C. Farinon, F. Geissel, H. Haettner, E. Heil, M. Kempley, R. S. Kozhuharov, C. Knoebel, R. Kurcewicz, J. Kuzminchuk, N. Litvinov, S. A. Liu, Z. Mao, R. Nociforo, C. Nolden, F. Patyk, Z. Plass, W. R. Prochazka, A. Reed, M. W. Sanjari, M. S. Scheidenberger, C. Steck, M. Stoehlker, Th Sun, B. Swan, T. P. D. Trees, G. Walker, P. M. Weick, H. Winckler, N. Winkler, M. Woods, P. J. Yamaguchi, T. Zhou, C. TI Schottky mass measurements of heavy neutron-rich nuclides in the element range 70 <= Z <= 79 at the GSI Experimental Storage Ring SO PHYSICAL REVIEW C LA English DT Article ID FRS-ESR FACILITY; ADJUSTMENT PROCEDURES; PROJECTILE FRAGMENTS; INPUT DATA; NUCLEI; SPECTROMETRY AB Storage-ring mass spectrometry was applied to neutron-rich Au-197 projectile fragments. Masses of Lu-181,Lu-183, Hf-185,Hf-186, Ta-187,Ta-188, W-191, and Re-192,Re-193 nuclei were measured for the first time. The uncertainty of previously known masses of W-189,W-190 and Os-195 nuclei was improved. Observed irregularities on the smooth two-neutron separation energies for Hf and W isotopes are linked to the collectivity phenomena in the corresponding nuclei. C1 [Shubina, D.; Cakirli, R. B.; Litvinov, Yu A.; Blaum, K.; Winckler, N.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany. [Shubina, D.] Heidelberg Univ, Fak Phys & Astron, D-69120 Heidelberg, Germany. [Shubina, D.; Litvinov, Yu A.; Brandau, C.; Bosch, F.; Dimopoulou, C.; Farinon, F.; Geissel, H.; Heil, M.; Kozhuharov, C.; Knoebel, R.; Kurcewicz, J.; Litvinov, S. A.; Nociforo, C.; Nolden, F.; Prochazka, A.; Sanjari, M. S.; Scheidenberger, C.; Steck, M.; Stoehlker, Th; Weick, H.; Winckler, N.; Winkler, M.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany. [Cakirli, R. B.] Istanbul Univ, Dept Phys, Istanbul, Turkey. [Brandau, C.] GSI Helmholtzzentrum Schwerionenforsch, ExtreMe Matter Inst EMMI, D-64291 Darmstadt, Germany. [Carroll, J. J.] US Army Res Lab, Adelphi, MD USA. [Casten, R. F.; Zhou, C.] Yale Univ, Wright Nucl Struct Lab, New Haven, CT 06520 USA. [Cullen, D. M.] Univ Manchester, Schuster Lab, Manchester M13 9PL, Lancs, England. [Cullen, I. J.; Deo, A. Y.; Kempley, R. S.; Reed, M. W.; Swan, T. P. D.; Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. [Detwiler, B.; Trees, G.] Youngstown State Univ, Youngstown, OH 44555 USA. [Geissel, H.; Haettner, E.; Kuzminchuk, N.; Plass, W. R.; Scheidenberger, C.; Sun, B.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany. [Liu, Z.; Woods, P. J.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland. [Liu, Z.; Mao, R.] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China. [Patyk, Z.] Natl Ctr Nucl Res, PL-00681 Warsaw, Poland. [Reed, M. W.] Australian Natl Univ, RSPE, Dept Nucl Phys, Canberra, ACT 0200, Australia. [Sanjari, M. S.] Goethe Univ Frankfurt, D-60438 Frankfurt, Germany. [Stoehlker, Th] Univ Jena, D-07737 Jena, Germany. [Stoehlker, Th] Helmholtz Inst Jena, D-07743 Jena, Germany. [Sun, B.] Beihang Univ, Sch Phys & Nucl Energy Engn, Beijing 100191, Peoples R China. [Kurcewicz, J.; Walker, P. M.] CERN, CH-1211 Geneva 23, Switzerland. [Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan. RP Shubina, D (reprint author), Max Planck Inst Kernphys, Saupfercheckweg 1, D-69117 Heidelberg, Germany. RI Sun, Baohua/C-6823-2009 OI Sun, Baohua/0000-0001-9868-5711 FU BMBF grant in the framework of the Internationale Zusammenarbeit in Bildung und Forschung Projekt [FKZ 01DO12012]; Alliance Program of the Helmholtz Association [HA216/EMMI]; Max Planck Society; US Department of Energy [DE-FG02-91ER-40609]; Helmholtz-CAS Joint Research Group [HCJRG-108]; External Cooperation Program of the Chinese Academy of Sciences [GJHZ1305]; International Max Planck Research School for Precision Tests of Fundamental Symmetries at MPIK; Humboldt Foundation; ESF within the Euro-GENESIS program; Nuclear Astrophysics Virtual Institute (NAVI) of the Helmholtz Association; Narodowe Centrum Nauki (Poland) [2011/01/B/ST2/05131]; Helmholtz International Centre for FAIR within the framework of the LOEWE program; NCET, NSFC [10975008, 11105010, 11035007]; UK STFC; AWE plc; Japanese Ministry of Education, Science and Culture [A19204023] FX The authors would like to thank the GSI accelerator team for the excellent technical support. This work was supported by a BMBF grant in the framework of the Internationale Zusammenarbeit in Bildung und Forschung Projekt (FKZ 01DO12012), by the Alliance Program of the Helmholtz Association (HA216/EMMI), by the Max Planck Society, and by the US Department of Energy under Grant No. DE-FG02-91ER-40609, by the Helmholtz-CAS Joint Research Group HCJRG-108, and by the External Cooperation Program of the Chinese Academy of Sciences (Grant No. GJHZ1305). D.S. is supported by the International Max Planck Research School for Precision Tests of Fundamental Symmetries at MPIK. R.B.C. thanks the Humboldt Foundation for support. K.B. and Y.A.L. thank ESF for support within the Euro-GENESIS program. K.B. acknowledge support by the Nuclear Astrophysics Virtual Institute (NAVI) of the Helmholtz Association. Z.P. would like to acknowledge the financial support from Narodowe Centrum Nauki (Poland) Grant No. 2011/01/B/ST2/05131. M.S.S. acknowledges support by the Helmholtz International Centre for FAIR within the framework of the LOEWE program launched by the State of Hesse. B.S. is partially supported by NCET, NSFC (Grants No. 10975008, No. 11105010, and No. 11035007). P.M.W. acknowledges the support by the UK STFC and AWE plc. T.Y. is grateful for Grant-in-Aid for Scientific Research No. A19204023 by the Japanese Ministry of Education, Science and Culture. NR 29 TC 18 Z9 18 U1 0 U2 17 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD AUG 13 PY 2013 VL 88 IS 2 AR 024310 DI 10.1103/PhysRevC.88.024310 PG 9 WC Physics, Nuclear SC Physics GA 200ET UT WOS:000323051300001 ER PT J AU Rodak, LE Sampath, AV Gallinat, CS Chen, Y Zhou, Q Campbell, JC Shen, H Wraback, M AF Rodak, L. E. Sampath, A. V. Gallinat, C. S. Chen, Y. Zhou, Q. Campbell, J. C. Shen, H. Wraback, M. TI Solar-blind AlxGa1-xN/AlN/SiC photodiodes with a polarization-induced electron filter SO APPLIED PHYSICS LETTERS LA English DT Article ID 4H-SIC AVALANCHE PHOTODIODES; TRANSPORT AB Heterogeneous n-III-nitride/i-p silicon carbide (SiC) photodetectors have been demonstrated that enable the tailoring of the spectral response in the solar blind region below 280 nm. The negative polarization induced charge at the aluminum gallium nitride (AlxGa1-xN)/aluminum nitride (AlN) interface in conjunction with the positive polarization charge at the AlN/SiC interface creates a large barrier to carrier transport across the interface that results in the selective collection of electrons photoexcited to the Gamma and L valleys of SiC while blocking the transport of electrons generated in the M valley. In addition, the AlxGa1-xN alloys act as transparent windows that enhance the collection of carriers generated by high energy photons in the fully depleted SiC absorption regions. These two factors combine to create a peak external quantum efficiency of 76% at 242 nm, along with a strong suppression of the long-wavelength response from 260 nm to 380 nm. (C) 2013 AIP Publishing LLC. C1 [Rodak, L. E.; Sampath, A. V.; Gallinat, C. S.; Shen, H.; Wraback, M.] RDRL SEE M, US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Chen, Y.; Zhou, Q.; Campbell, J. C.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22903 USA. RP Rodak, LE (reprint author), RDRL SEE M, US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU U.S. Army Research Laboratory FX L. E. Rodak and C. S. Gallinat gratefully acknowledge support from the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. The authors would like to thank E. Bellotti for helpful discussions regarding the saturation velocity and hot electron relaxation time in 4H-SiC. NR 13 TC 4 Z9 4 U1 1 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 12 PY 2013 VL 103 IS 7 AR 071110 DI 10.1063/1.4818551 PG 4 WC Physics, Applied SC Physics GA 209OS UT WOS:000323769000010 ER PT J AU DeLacy, BG Qiu, WJ Soljacic, M Hsu, CW Miller, OD Johnson, SG Joannopoulos, JD AF DeLacy, Brendan G. Qiu, Wenjun Soljacic, Marin Hsu, Chia Wei Miller, Owen D. Johnson, Steven G. Joannopoulos, John D. TI Layer-by-layer self-assembly of plexcitonic nanoparticles SO OPTICS EXPRESS LA English DT Article ID ASPECT-RATIO; SILVER; NANORODS; RAMAN; AU AB Colloidal suspensions of multilayer nanoparticles composed of a silver core, a polyelectrolyte spacer layer (inner shell), and a J-aggregate cyanine dye outer shell have been prepared for the first time. Absorption properties of the colloid were measured in the visible region. This multilayer architecture served as a framework for examining the coupling of the localized surface plasmon resonance exhibited by the silver core with the molecular exciton exhibited by the J-aggregate outer shell. The polyelectrolyte spacer layer promotes the formation of an excitonic J-aggregate while serving as a means of controlling the plasmon-exciton (i.e. plexciton) coupling strength through changing the distance between the core and the shell. An analytical expression based on Mie Theory and the Transfer Matrix Method was obtained for describing the optical response of these multilayered nanostructures. Computational and experimental results indicate that the absorption wavelength of the J-aggregate form of the dye is dependent on both the distance of the dye layer from the silver core and the degree of dye aggregation. (c) 2013 Optical Society of America C1 [DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Qiu, Wenjun; Soljacic, Marin; Hsu, Chia Wei; Joannopoulos, John D.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Miller, Owen D.; Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA. RP DeLacy, BG (reprint author), US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM brendan.g.delacy.civ@mail.mil RI Hsu, Chia Wei/G-5486-2011; Miller, Owen/A-6354-2014 OI Hsu, Chia Wei/0000-0002-9609-7155; Miller, Owen/0000-0003-2745-2392 FU Department of the Army Basic Research Program; Edgewood Chemical Biological Center; U.S. Army Research Office [W911NF-13-D-0001] FX This research was funded by the Department of the Army Basic Research Program and sponsored by the Edgewood Chemical Biological Center. Support was also provided by the U.S. Army Research Office under contract W911NF-13-D-0001. Special thanks to Dr. Michael McCaffery of the Johns Hopkins University Integrated Imaging Center for his assistance with the TEM images. NR 34 TC 8 Z9 8 U1 6 U2 50 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 12 PY 2013 VL 21 IS 16 BP 19103 EP 19112 DI 10.1364/OE.21.019103 PG 10 WC Optics SC Optics GA 200EF UT WOS:000323049900049 PM 23938825 ER PT J AU Linhoss, AC Kiker, GA Aiello-Lammens, ME Chu-Agor, ML Convertino, M Munoz-Carpena, R Fischer, R Linkov, I AF Linhoss, Anna C. Kiker, Gregory A. Aiello-Lammens, Matthew E. Chu-Agor, Ma. Librada Convertino, Matteo Munoz-Carpena, Rafael Fischer, Richard Linkov, Igor TI Decision analysis for species preservation under sea-level rise SO ECOLOGICAL MODELLING LA English DT Article DE Multi-criteria decision analysis; Snowy Plover; Ecological modeling; Sea-level rise; Scenario planning ID SNOWY PLOVERS; HABITAT; DISTRIBUTIONS; PERSPECTIVE; SHOREBIRDS; MANAGEMENT; IMPACT; BEACH AB Sea-level rise is expected to dramatically alter low-lying coastal and intertidal areas, which provide important habitat for shoreline-dependent species. The Snowy Plover (Charadrius alexandrinus) is a threatened shorebird that relies on Florida Gulf Coast sandy beaches for nesting and breeding. Selecting a management strategy for the conservation of this species under sea-level rise is a complex task that entails the consideration of multiple streams of information, stakeholder preferences, value judgments, and uncertainty. We use a spatially explicit linked modeling process that incorporates geomorphological (SLAMM), habitat (MaxEnt), and metapopulation (RAMAS GIS) models to simulate the effect of sea-level rise on Snowy Plover populations. We then apply multi-criteria decision analysis to identify preferred management strategies for the conservation of the species. Results show that nest exclosures are the most promising conservation strategy followed by predator management, species focused beach nourishment, and no action. Uncertainty in these results remains an important concern, and a better understanding of decision-maker preferences and the Snowy Plover's life history would improve the reliability of the results. This is an innovative method for planning for sea-level rise through pairing a linked modeling system with decision analysis to provide management focused results under an inherently uncertain future. Published by Elsevier B.V. C1 [Linhoss, Anna C.] Mississippi State Univ, Starkville, MS 39762 USA. [Linhoss, Anna C.; Kiker, Gregory A.; Convertino, Matteo; Munoz-Carpena, Rafael] Univ Florida, Gainesville, FL 32611 USA. [Aiello-Lammens, Matthew E.] SUNY Stony Brook, Dept Ecol & Evolut, New York, NY 11794 USA. [Chu-Agor, Ma. Librada] St Louis Univ, Ctr Environm Sci, St Louis, MO 63103 USA. [Fischer, Richard; Linkov, Igor] US Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 69184 USA. [Kiker, Gregory A.] Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Kwa Zulu, South Africa. RP Linhoss, AC (reprint author), Mississippi State Univ, 130 Creelman St, Starkville, MS 39762 USA. EM alinhoss@abe.msstate.edu RI Munoz-Carpena, Rafael/A-7588-2010; OI Munoz-Carpena, Rafael/0000-0003-2838-1514; Chu, Ma Librada/0000-0003-3732-7165; Aiello-Lammens, Matthew/0000-0002-6180-5959 FU Department of Defense Strategic Environmental Research and Development Program [SI-1699] FX Funding for this project was provided by the Department of Defense Strategic Environmental Research and Development Program (project SI-1699). Permission for publishing this material was granted by the USACE Chief of Engineers. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 50 TC 5 Z9 5 U1 3 U2 60 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD AUG 10 PY 2013 VL 263 BP 264 EP 272 DI 10.1016/j.ecolmodel.2013.05.014 PG 9 WC Ecology SC Environmental Sciences & Ecology GA 197NJ UT WOS:000322857600025 ER PT J AU McWilliams, B Sano, T Yu, J Gordon, A Yen, C AF McWilliams, B. Sano, T. Yu, J. Gordon, A. Yen, C. TI Influence of hot rolling on the deformation behavior of particle reinforced aluminum metal matrix composite SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Composites; Thermomechanical processing; Finite element method; Micromechanics ID IMAGE CORRELATION PHOTOGRAMMETRY; FIELD DYNAMIC DISPLACEMENT; A359 ALUMINUM; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; DAMAGE; STRAIN; FRACTURE; FAILURE; ALLOY AB This paper presents the development of a microstructure based finite element model to predict the effective mechanical response and study the failure mechanisms of a particulate metal matrix composite (MMC) which explicitly accounts for changes in microstructure due to thermo-mechanical processing from the as-cast to rolled states. Experimental testing including macro-scale tension, in-situ SEM microscale tension, and nano-indentation were used to characterize the deformation behavior and active failure mechanisms. It was found that the damage mechanism transitions from being dominated by void nucleation and growth in the matrix in the as-cast state to interfacial decohesion and particle fracture in the rolled material. The numerical model is used to quantify the contribution of interfacial decohesion and particle fracture damage mechanisms to the local and global continuum response of a hot rolled A359/pSiC MMC. (C) 2013 Elsevier B.V. All rights reserved. C1 [McWilliams, B.; Sano, T.; Yu, J.; Yen, C.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 20015 USA. [Gordon, A.] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Orlando, FL 32816 USA. RP McWilliams, B (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 20015 USA. EM brandon.a.mcwilliams.ctr@mail.mil; tomoko.sano.civ@mail.mil; jian.h.yu.ctr@mail.mil; ali.gordon@ucf.edu; chianfong.yen.civ@mail.mil FU Oak Ridge Institute for Science and Education (ORISE) post-doctoral fellowship at the US Army Research Laboratory FX B. McWilliams acknowledges financial support for this work provided by an Oak Ridge Institute for Science and Education (ORISE) post-doctoral fellowship at the US Army Research Laboratory. NR 43 TC 5 Z9 6 U1 3 U2 35 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD AUG 10 PY 2013 VL 577 BP 54 EP 63 DI 10.1016/j.msea.2013.03.039 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 170GD UT WOS:000320837500009 ER PT J AU Sethi, J Palit, R Saha, S Trivedi, T Bhat, GH Sheikh, JA Datta, P Carroll, JJ Chattopadhyay, S Donthi, R Garg, U Jadhav, S Jain, HC Karamian, S Kumar, S Litz, MS Mehta, D Naidu, BS Naik, Z Sihotra, S Walker, PM AF Sethi, J. Palit, R. Saha, S. Trivedi, T. Bhat, G. H. Sheikh, J. A. Datta, P. Carroll, J. J. Chattopadhyay, S. Donthi, R. Garg, U. Jadhav, S. Jain, H. C. Karamian, S. Kumar, S. Litz, M. S. Mehta, D. Naidu, B. S. Naik, Z. Sihotra, S. Walker, P. M. TI Structure of nearly degenerate dipole bands in Ag-108 SO PHYSICS LETTERS B LA English DT Article ID PROJECTED SHELL-MODEL; ROTATION; NUCLEI; ISOTOPES; PARITY AB The high spin negative parity states of Ag-108 have been investigated with the B-11 + Mo-100 reaction at 39 MeV beam energy using the INCA facility at TIFR, Mumbai. From the gamma-gamma coincidence analysis, an excited negative parity band has been established and found to be nearly degenerate with the ground state band. The spin and parity of the levels are assigned using angular correlation and polarization measurements. This pair of degenerate bands in Ag-108 is studied using the recently developed microscopic triaxial projected shell model approach. The observed energy levels and the ratio of the electromagnetic transition probabilities of these bands in this isotope are well reproduced by the present model. Further, it is shown that the partner band has a different quasiparticle structure as compared to the yrast band. (C) 2013 Elsevier B.V. All rights reserved. C1 [Sethi, J.; Palit, R.; Saha, S.; Trivedi, T.; Donthi, R.; Jadhav, S.; Jain, H. C.; Naidu, B. S.] Tata Inst Fundamental Res, Bombay 400005, Maharashtra, India. [Bhat, G. H.; Sheikh, J. A.] Univ Kashmir, Dept Phys, Srinagar 190006, Jammu & Kashmir, India. [Datta, P.] Ananda Mohan Coll, Kolkata 700009, India. [Carroll, J. J.; Litz, M. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Chattopadhyay, S.] Saha Inst Nucl Phys, Kolkata 700064, India. [Garg, U.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Karamian, S.] Joint Inst Nucl Res, Dubna 141980, Russia. [Kumar, S.] Univ Delhi, Delhi 110007, India. [Mehta, D.; Sihotra, S.] Panjab Univ, Chandigarh 160014, India. [Naik, Z.] Sambalpur Univ, Sambalpur 143005, India. [Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. RP Palit, R (reprint author), Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. EM palit@tifr.res.in RI Palit, Rudrajyoti/F-5185-2012 FU Department of Science and Technology, Government of India [IR/S2/PF-03/2003-I]; US National Science Foundation [PHY-1068192] FX Authors would like to thank the TIFR-BARC Pelletron Linac Facility staff for providing good quality beam. The help and cooperation of the members of the INGA collaboration for setting up the array are acknowledged. U.G. acknowledges the hospitality of colleagues at TIFR, Mumbai. This work was partially funded by the Department of Science and Technology, Government of India (No. IR/S2/PF-03/2003-I). Supported in part by the US National Science Foundation (Grant No. PHY-1068192). NR 38 TC 12 Z9 14 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0370-2693 J9 PHYS LETT B JI Phys. Lett. B PD AUG 9 PY 2013 VL 725 IS 1-3 BP 85 EP 91 DI 10.1016/j.physletb.2013.06.054 PG 7 WC Astronomy & Astrophysics; Physics, Nuclear; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA 194BU UT WOS:000322606800008 ER PT J AU Wiszniewski, W Hunter, JV Hanchard, NA Willer, JR Shaw, C Tian, Q Illner, A Wang, XQ Cheung, SW Patel, A Campbell, IM Gelowani, V Hixson, P Ester, AR Azamian, MS Potocki, L Zapata, G Hernandez, PP Ramocki, MB Santos-Cortez, RLP Wang, G York, MK Justice, MJ Chu, ZLD Bader, PI Omo-Griffith, L Madduri, NS Scharer, G Crawford, HP Yanatatsaneejit, P Eifert, A Kerr, J Bacino, CA Franklin, AIA Goin-Kochel, RP Simpson, G Immken, L Haque, ME Stosic, M Williams, MD Morgan, TM Pruthi, S Omary, R Boyadjiev, SA Win, KK Thida, A Hurles, M Hibberd, ML Khor, CC Chau, NVV Gallagher, TE Mutirangura, A Stankiewicz, P Beaudet, AL Maletic-Savatic, M Rosenfeld, JA Shaffer, LG Davis, EE Belmont, JW Dunstan, S Simmons, CP Bonnen, PE Leal, SM Katsanis, N Lupski, JR Lalani, SR AF Wiszniewski, Wojciech Hunter, Jill V. Hanchard, Neil A. Willer, Jason R. Shaw, Chad Tian, Qi Illner, Anna Wang, Xueqing Cheung, Sau W. Patel, Ankita Campbell, Ian M. Gelowani, Violet Hixson, Patricia Ester, Audrey R. Azamian, Mahshid S. Potocki, Lorraine Zapata, Gladys Hernandez, Patricia P. Ramocki, Melissa B. Santos-Cortez, Regie L. P. Wang, Gao York, Michele K. Justice, Monica J. Chu, Zili D. Bader, Patricia I. Omo-Griffith, Lisa Madduri, Nirupama S. Scharer, Gunter Crawford, Heather P. Yanatatsaneejit, Pattamawadee Eifert, Anna Kerr, Jeffery Bacino, Carlos A. Franklin, Adiaha I. A. Goin-Kochel, Robin P. Simpson, Gayle Immken, Ladonna Haque, Muhammad E. Stosic, Marija Williams, Misti D. Morgan, Thomas M. Pruthi, Sumit Omary, Reed Boyadjiev, Simeon A. Win, Kay K. Thida, Aye Hurles, Matthew Hibberd, Martin Lloyd Khor, Chiea Chuen Chau, Nguyen Van Vinh Gallagher, Thomas E. Mutirangura, Apiwat Stankiewicz, Pawel Beaudet, Arthur L. Maletic-Savatic, Mirjana Rosenfeld, Jill A. Shaffer, Lisa G. Davis, Erica E. Belmont, John W. Dunstan, Sarah Simmons, Cameron P. Bonnen, Penelope E. Leal, Suzanne M. Katsanis, Nicholas Lupski, James R. Lalani, Seema R. TI TM4SF20 Ancestral Deletion and Susceptibility to a Pediatric Disorder of Early Language Delay and Cerebral White Matter Hyperintensities SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID INCIDENTAL FINDINGS; DEVELOPMENTAL DELAY; MR-IMAGES; BRAIN; CHILDREN; POPULATION; PREVALENCE; SPEECH AB White matter hyperintensities (WMHs) of the brain are important markers of aging and small-vessel disease. WMHs are rare in healthy children and, when observed, often occur with comorbid neuroinflammatory or vasculitic processes. Here, we describe a complex 4 kb deletion in 2q36.3 that segregates with early childhood communication disorders and WMH in 15 unrelated families predominantly from Southeast Asia. The premature brain aging phenotype with punctate and multifocal WMHs was observed in similar to 70% of young carrier parents who underwent brain MRI. The complex deletion removes the penultimate exon 3 of TM4SF20, a gene encoding a transmembrane protein of unknown function. Minigene analysis showed that the resultant net loss of an exon introduces a premature stop codon, which, in turn, leads to the generation of a stable protein that fails to target to the plasma membrane and accumulates in the cytoplasm. Finally, we report this deletion to be enriched in individuals of Vietnamese Kinh descent, with an allele frequency of about 1%, embedded in an ancestral haplotype. Our data point to a constellation of early language delay and WMH phenotypes, driven by a likely toxic mechanism of TM4SF20 truncation, and highlight the importance of understanding and managing population-specific low-frequency pathogenic alleles. C1 [Wiszniewski, Wojciech; Hanchard, Neil A.; Shaw, Chad; Tian, Qi; Wang, Xueqing; Cheung, Sau W.; Patel, Ankita; Campbell, Ian M.; Gelowani, Violet; Hixson, Patricia; Ester, Audrey R.; Azamian, Mahshid S.; Potocki, Lorraine; Zapata, Gladys; Hernandez, Patricia P.; Santos-Cortez, Regie L. P.; Wang, Gao; Justice, Monica J.; Crawford, Heather P.; Bacino, Carlos A.; Stankiewicz, Pawel; Beaudet, Arthur L.; Belmont, John W.; Bonnen, Penelope E.; Leal, Suzanne M.; Lupski, James R.; Lalani, Seema R.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. [Hunter, Jill V.; Illner, Anna; Chu, Zili D.] Texas Childrens Hosp, Dept Pediat Radiol, Houston, TX 77030 USA. [Hanchard, Neil A.; Lupski, James R.] Texas Childrens Hosp, Dept Pediat, Houston, TX 77030 USA. [Hanchard, Neil A.; Davis, Erica E.; Belmont, John W.; Lalani, Seema R.] Baylor Coll Med, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA. [Willer, Jason R.; Katsanis, Nicholas] Duke Univ, Med Ctr, Ctr Human Dis Modeling, Durham, NC 27710 USA. [Ramocki, Melissa B.; Stosic, Marija; Maletic-Savatic, Mirjana] Texas Childrens Hosp, Baylor Coll Med, Jan & Dan Duncan Neurol Res Inst, Dept Pediat & Neurosci, Houston, TX 77030 USA. [York, Michele K.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA. [Bader, Patricia I.; Omo-Griffith, Lisa] Northeast Indiana Genet Counseling Ctr, Ft Wayne, IN 46845 USA. [Madduri, Nirupama S.] Vanderbilt Univ, Div Dev Med, Nashville, TN 37232 USA. [Scharer, Gunter] Childrens Hosp, Dept Pediat, Aurora, CO 80045 USA. [Yanatatsaneejit, Pattamawadee; Mutirangura, Apiwat] Chulalongkorn Univ, Ctr Excellence Mol Genet Canc & Human Dis, Bangkok 10330, Thailand. [Eifert, Anna] Texas Childrens Hosp, Dept Speech & Language, Houston, TX 77030 USA. [Kerr, Jeffery] Dells Childrens Med Ctr, Dept Neurol, Austin, TX 78723 USA. [Franklin, Adiaha I. A.] Texas Childrens Hosp, Dept Dev Pediat, Houston, TX 77030 USA. [Goin-Kochel, Robin P.] Baylor Coll Med, Dept Pediat, Psychol Sect, Houston, TX 77030 USA. [Goin-Kochel, Robin P.] Texas Childrens Hosp, Houston, TX 77030 USA. [Simpson, Gayle; Immken, Ladonna] Specially Children Dells Childrens Med Ctr, Austin, TX 78723 USA. [Williams, Misti D.; Morgan, Thomas M.] Vanderbilt Univ, Div Med Genet & Genom Med, Nashville, TN 37232 USA. [Pruthi, Sumit; Omary, Reed] Vanderbilt Univ, Nashville, TN 37232 USA. [Boyadjiev, Simeon A.] Univ Calif Davis, Dept Pediat, Genet Sect, Davis, CA 95817 USA. [Win, Kay K.] Harlem Hosp Med Ctr, Dept Med, New York, NY 10037 USA. [Thida, Aye] Allcare Pediat, Missouri City, TX 77459 USA. [Hurles, Matthew] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England. [Hibberd, Martin Lloyd; Khor, Chiea Chuen] Genome Inst Singapore, Singapore 138672, Singapore. [Chau, Nguyen Van Vinh] Hosp Trop Dis, Ho Chi Minh City, Vietnam. [Gallagher, Thomas E.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA. [Shaffer, Lisa G.] Genet Vet Sci Inc, Paw Print Genet, Spokane, WA 99202 USA. [Simmons, Cameron P.] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam. [Bonnen, Penelope E.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA. RP Lalani, SR (reprint author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. EM seemal@bcm.tmc.edu OI Campbell, Ian/0000-0002-3749-2884; Hibberd, Martin/0000-0001-8587-1849; Dunstan, Sarah/0000-0001-7873-933X; Simmons, Cameron P./0000-0002-9039-7392; Shaw, Chad/0000-0001-7267-5398; Belmont, John/0000-0001-7409-3578; Katsanis, Nicholas/0000-0002-2480-0171; Khor, Chiea Chuen/0000-0002-1128-4729 FU Doris Duke Charitable Foundation (DDCF); Gillson Longenbaugh Foundation; National Institutes of Health [RO1-HL091771]; NINDS [RO1-NS058529-03, K23NS078056]; NHGRI [5U54HG006542]; NIMH [P50-MH094268]; Simons Foundation (SFARI) [239983]; Molecular Medicine Scholars Program at BCM [HL-66991]; NIH/NINDS [5K08NS062711]; McKnight Endowment for Science; Dana Foundation; NIH Intellectual and the Developmental Disabilities Research Grant [P30HD024064]; Children's Miracle Network endowed chair in pediatric genetics FX We are indebted to the families who participated in this research study. Support for this work was provided by the Doris Duke Charitable Foundation (DDCF) and Gillson Longenbaugh Foundation to S.R.L., National Institutes of Health (RO1-HL091771) to J.W.B. and S.R.L., NINDS (RO1-NS058529-03) and NHGRI (5U54HG006542) to J.R.L.; and NIMH (P50-MH094268) and a grant from the Simons Foundation (SFARI # 239983) to N.K. W.W. is supported by a Career Development Award K23NS078056 grant from the NINDS and Molecular Medicine Scholars Program at BCM (HL-66991). M.B.R. is grateful for the support of grant 5K08NS062711 from the NIH/NINDS. M.M.-S. was supported by the McKnight Endowment for Science, Dana Foundation, and the NIH Intellectual and the Developmental Disabilities Research Grant (P30HD024064). S.A.B. is partially funded by a Children's Miracle Network endowed chair in pediatric genetics. N.K. is a Distinguished Jean and George W. Brumley Professor. We thank Emily Hall and Jillian Pearring for technical support. The Department of Molecular and Human Genetics at Baylor College of Medicine offers extensive genetic laboratory testing, including chromosomal microarray analysis, and derives revenue from this activity. J.A.R. is an employee of Signature Genomic Laboratories, a subsidiary of PerkinElmer, Inc. NR 29 TC 16 Z9 17 U1 0 U2 8 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 EI 1537-6605 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD AUG 8 PY 2013 VL 93 IS 2 BP 197 EP 210 DI 10.1016/j.ajhg.2013.05.027 PG 14 WC Genetics & Heredity SC Genetics & Heredity GA 202AP UT WOS:000323186200001 PM 23810381 ER PT J AU Alemayehu, S Feghali, KC Cowden, J Komisar, J Ockenhouse, CF Kamau, E AF Alemayehu, Saba Feghali, Karla C. Cowden, Jessica Komisar, Jack Ockenhouse, Christian F. Kamau, Edwin TI Comparative evaluation of published real-time PCR assays for the detection of malaria following MIQE guidelines SO MALARIA JOURNAL LA English DT Article ID POLYMERASE-CHAIN-REACTION; PLASMODIUM-FALCIPARUM; QUANTITATIVE PCR; IMPORTED MALARIA; DIAGNOSIS; MICROSCOPY; PARASITES; EFFICACY; BLOOD; RNA AB Background: The use of malaria-specific quantitative real-time PCR (qPCR) is increasing due to its high sensitivity, speciation and quantification of malaria parasites. However, due to the lack of consensus or standardized methods in performing qPCR, it is difficult to evaluate and/or compare the quality of work reported by different authors for a cross-study and/or cross-platform assay analysis. Methods: The performances of seven published qPCR assays that detect Plasmodium spp or Plasmodium falciparum were compared using standard DNA and samples from a clinical trial. Amplification and qPCR measurements were performed using the Applied Biosystems 7500 Fast Real-Time PCR System. All the analyses were automatically established using the default settings. For the TaqMan probe format, the assays were performed in the background of QuantiFast Probe Master Mix whereas in SYBR Green format, the assays were performed in the background of QuantiFast SYBR Green Master Mix and QuantiTect SYBR Green Master Mix background. Results: Assays with high PCR efficiencies outperformed those with low efficiencies in all categories including sensitivity, precision and consistency regardless of the assay format and background. With the exception of one assay, all assays evaluated showed lower sensitivity compared to what have been published. When samples from a malaria challenge study were analysed, the qPCR assay with the overall best performance detected parasites in subjects earliest and with most consistency. Conclusion: The data demonstrate the need for increased consensus and guidelines that will encourage better experimental practices, allowing more consistent and unambiguous interpretation of qPCR results. C1 [Alemayehu, Saba; Feghali, Karla C.; Cowden, Jessica; Komisar, Jack; Ockenhouse, Christian F.; Kamau, Edwin] Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM edwin.kamau@us.army.mil NR 27 TC 18 Z9 19 U1 0 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 8 PY 2013 VL 12 AR 277 DI 10.1186/1475-2875-12-277 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 198VY UT WOS:000322952000001 PM 23927553 ER PT J AU Elster, EA Butler, FK Rasmussen, TE AF Elster, Eric A. Butler, Frank K. Rasmussen, Todd E. TI Implications of Combat Casualty Care for Mass Casualty Events SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID BATTLEFIELD; MORTALITY; DEATH C1 [Elster, Eric A.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Elster, Eric A.] Naval Med Res Ctr, Silver Spring, MD USA. [Butler, Frank K.; Rasmussen, Todd E.] US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX USA. RP Elster, EA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM eric.elster@usuhs.edu NR 10 TC 21 Z9 21 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 7 PY 2013 VL 310 IS 5 BP 475 EP 476 DI 10.1001/jama.2013.167481 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 196OZ UT WOS:000322786400014 PM 23925612 ER PT J AU LeardMann, CA Powell, TM Smith, TC Bell, MR Smith, B Boyko, EJ Hooper, TI Gackstetter, GD Ghamsary, M Hoge, CW AF LeardMann, Cynthia A. Powell, Teresa M. Smith, Tyler C. Bell, Michael R. Smith, Besa Boyko, Edward J. Hooper, Tomoko I. Gackstetter, Gary D. Ghamsary, Mark Hoge, Charles W. TI Risk Factors Associated With Suicide in Current and Former US Military Personnel SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-DEATH-INDEX; MILLENNIUM COHORT; SERVICE MEMBERS; PRIMARY-CARE; VITAL STATUS; FOLLOW-UP; PRIME-MD; HEALTH; POPULATION AB IMPORTANCE Beginning in 2005, the incidence of suicide deaths in the US military began to sharply increase. Unique stressors, such as combat deployments, have been assumed to underlie the increasing incidence. Previous military suicide studies, however, have relied on case series and cross-sectional investigations and have not linked data during service with postservice periods. OBJECTIVE To prospectively identify and quantify risk factors associated with suicide in current and former US military personnel including demographic, military, mental health, behavioral, and deployment characteristics. DESIGN, SETTING, AND PARTICIPANTS Prospective longitudinal study with accrual and assessment of participants in 2001, 2004, and 2007. Questionnaire data were linked with the National Death Index and the Department of Defense Medical Mortality Registry through December 31, 2008. Participants were current and former US military personnel from all service branches, including active and Reserve/National Guard, who were included in the Millennium Cohort Study (N = 151 560). MAIN OUTCOMES AND MEASURES Death by suicide captured by the National Death Index and the Department of Defense Medical Mortality Registry. RESULTS Through the end of 2008, findings were 83 suicides in 707 493 person-years of follow-up (11.73/100 000 person-years [95% CI, 9.21-14.26]). In Cox models adjusted for age and sex, factors significantly associated with increased risk of suicide included male sex, depression, manic-depressive disorder, heavy or binge drinking, and alcohol-related problems. None of the deployment-related factors (combat experience, cumulative days deployed, or number of deployments) were associated with increased suicide risk in any of the models. In multivariable Cox models, individuals with increased risk for suicide were men (hazard ratio [HR], 2.14; 95% CI, 1.17-3.92; P = .01; attributable risk [AR], 3.5 cases/10 000 persons), and those with depression (HR, 1.96; 95% CI, 1.05-3.64; P = .03; AR, 6.9/10 000 persons), manic-depressive disorder (HR, 4.35; 95% CI, 1.56-12.09; P = .005; AR, 35.6/10 000 persons), or alcohol-related problems (HR, 2.56; 95% CI, 1.56-4.18; P < .001; AR, 7.7/10 000 persons). A nested, matched case-control analysis using 20: 1 control participants per case confirmed these findings. CONCLUSIONS AND RELEVANCE In this sample of current and former military personnel observed July 1, 2001-December 31, 2008, suicide risk was independently associated with male sex and mental disorders but not with military-specific variables. These findings may inform approaches to mitigating suicide risk in this population. C1 [LeardMann, Cynthia A.; Powell, Teresa M.; Smith, Tyler C.; Smith, Besa] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Smith, Tyler C.] Natl Univ, Sch Hlth & Human Serv, San Diego, CA USA. [Smith, Besa] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Bell, Michael R.; Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Ghamsary, Mark] Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP LeardMann, CA (reprint author), Naval Hlth Res Ctr, Dept Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM cynthia.leardmann@med.navy.mil FU Department of Defense [12-53, 60002]; Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland; VA Puget Sound Health Care System FX This work represents report 12-53, supported by the Department of Defense, under work unit no. 60002. The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. Dr Boyko's effort in this project was supported by VA Puget Sound Health Care System. NR 38 TC 107 Z9 107 U1 4 U2 33 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 7 PY 2013 VL 310 IS 5 BP 496 EP 506 DI 10.1001/jama.2013.65164 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 196OZ UT WOS:000322786400022 PM 23925620 ER PT J AU Mitchell, J Pabon, N Collier, ZA Egeghy, PP Cohen-Hubal, E Linkov, I Vallero, DA AF Mitchell, Jade Pabon, Nicolas Collier, Zachary A. Egeghy, Peter P. Cohen-Hubal, Elaine Linkov, Igor Vallero, Daniel A. TI A Decision Analytic Approach to Exposure-Based Chemical Prioritization SO PLOS ONE LA English DT Article AB The manufacture of novel synthetic chemicals has increased in volume and variety, but often the environmental and health risks are not fully understood in terms of toxicity and, in particular, exposure. While efforts to assess risks have generally been effective when sufficient data are available, the hazard and exposure data necessary to assess risks adequately are unavailable for the vast majority of chemicals in commerce. The US Environmental Protection Agency has initiated the ExpoCast Program to develop tools for rapid chemical evaluation based on potential for exposure. In this context, a model is presented in which chemicals are evaluated based on inherent chemical properties and behaviorally-based usage characteristics over the chemical's life cycle. These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling. A case study outlines the prioritization process using 51 chemicals. The results show a preliminary relative ranking of chemicals based on exposure potential. The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies. C1 [Mitchell, Jade] Michigan State Univ, E Lansing, MI 48824 USA. [Pabon, Nicolas] Carnegie Mellon Univ, Dept Phys, Pittsburgh, PA 15213 USA. [Collier, Zachary A.; Linkov, Igor] USA, Environm Lab, Engn Res & Dev Ctr, Corps Engineers, Concord, MA USA. [Egeghy, Peter P.; Cohen-Hubal, Elaine; Vallero, Daniel A.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Linkov, I (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, Corps Engineers, Concord, MA USA. EM Igor.Linkov@usace.army.mil FU United States Environmental Protection Agency through its Office of Research and Development; U.S. Army Corps of Engineers [DW-96-95807601-0] FX The United States Environmental Protection Agency through its Office of Research and Development (funded and managed or partially funded and collaborated in) the research described here under an Interagency Agreement with the U.S. Army Corps of Engineers (DW-96-95807601-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 8 Z9 8 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 5 PY 2013 VL 8 IS 8 AR UNSP e70911 DI 10.1371/journal.pone.0070911 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 218XC UT WOS:000324465000153 PM 23940664 ER PT J AU Blunden, J Arndt, DS Achberger, C Ackerman, SA Albanil, A Alexander, P Alfaro, EJ Allan, R Alves, LM Amador, JA Ambenje, P Andrianjafinirina, S Antonov, J Aravequia, JA Arendt, A Arevalo, J Ashik, I Atheru, Z Banzon, V Baringer, MO Barreira, S Barriopedro, DE Beard, G Becker, A Behrenfeld, MJ Bell, GD Benedetti, A Bernhard, G Berrisford, P Berry, DI Bhatt, U Bidegain, M Bindoff, N Bissolli, P Blake, ES Booneeady, R Bosilovich, M Box, JE Boyer, T Braathen, GO Bromwich, DH Brown, R Brown, L Bruhwiler, L Bulygina, ON Burgess, D Burrows, J Calderon, B Camargo, SJ Campbell, J Cao, Y Cappelen, J Carrasco, G Chambers, DP Chang'a, L Chappell, P Chehade, W Cheliah, M Christiansen, HH Christy, JR Ciais, P Coelho, CAS Cogley, JG Colwell, S Cross, JN Crouch, J Cunningham, SA Dacic, M De Jeu, RAM Dekaa, FS Demircan, M Derksen, C Diamond, HJ Dlugokencky, EJ Dohan, K Dolman, AJ Domingues, CM Dong, SF Dorigo, WA Drozdov, DS Duguay, CR Dunn, RJH Duran-Quesada, AM Dutton, GS Ehmann, C Elkins, JW Euscategui, C Famiglietti, JS Fang, F Fauchereau, N Feely, RA Fekete, BM Fenimore, C Fioletov, VE Fogarty, CT Fogt, RL Folland, CK Foster, MJ Frajka-Williams, E Franz, BA Frith, SH Frolov, I Ganter, C Garzoli, S Geai, ML Gerland, S Gitau, W Gleason, KL Gobron, N Goldenberg, SB Goni, G Good, SA Gottschalck, J Gregg, MC Griffiths, G Grooss, JU Guard, C Gupta, SK Hall, BD Halpert, MS Harada, Y Hauri, C Heidinger, AK Heikkila, A Heim, RR Heimbach, P Hidalgo, HG Hilburn, K Ho, SP Hobbs, WR Holgate Hovsepyan, A Hu, ZZ Hughes, P Hurst, DF Ingvaldsen, R Inness, A Jaimes, E Jakobsson, M James, AI Jeffries, MO Johns, WE Johnsen, B Johnson, GC Johnson, B Jones, LT Jumaux, G Kabidi, K Kaiser, JW Kamga, A Kang, KK Kanzow, TO Kao, HY Keller, LM Kennedy, JJ Key, J Khatiwala, S Pour, HK Kholodov, AL Khoshkam, M Kijazi, A Kikuchi, T Kim, BM Kim, SJ Kimberlain, TB Knaff, JA Korshunova, NN Koskela, T Kousky, VE Kramarova, N Kratz, DP Krishfield, R Kruger, A Kruk, MC Kumar, A Lagerloef, GSE Lakkala, K Lander, MA Landsea, CW Lankhorst, M Laurila, T Lazzara, MA Lee, C Leuliette, E Levitus, S L'Heureux, M Lieser, J Lin, II Liu, YY Liu, Y Liu, HX Liu, YJ Lobato-Sanchez, R Locarnini, R Loeb, NG Loeng, H Long, CS Lorrey, AM Luhunga, P Lumpkin, R Luo, JJ Lyman, JM Macdonald, AM Maddux, BC Malekela, C Manney, G Marchenko, SS Marengo, JA Marotzke, J Marra, JJ Martinez-Guingla, R Massom, RA Mathis, JT McBride, C McCarthy, G McVicar, TR Mears, C Meier, W Meinen, CS Menendez, M Merrifield, MA Mitchard, E Mitchum, GT Montzka, SA Morcrette, JJ Mote, T Muhle, J Muhr, B Mullan, AB Muller, R Nash, ER Nerem, RS Newlin, ML Newman, PA Ng'ongolo, H Nieto, JJ Nishino, S Nitsche, H Noetzli, J Oberman, NG Obregon, A Ogallo, LA Oludhe, CS Omar, MI Overland, J Oyunjargal, L Parinussa, RM Park, GH Park, EH Parker, D Pasch, RJ Pascual-Ramirez, R Pelto, MS Penalba, O Peng, L Perovich, DK Pezza, AB Phillips, D Pickart, R Pinty, B Pitts, MC Purkey, SG Quegan, S Quintana, J Rabe, B Rahimzadeh, F Raholijao, N Raiva, I Rajeevan, M Ramiandrisoa, V Ramos, A Ranivoarissoa, S Rayner, NA Rayner, D Razuveav, VN Reagan, J Reid, P Renwick, J Revedekar, J Richter-Menge, J Rivera, IL Robinson, DA Rodell, M Romanovsky, VE Ronchail, J Rosenlof, KH Sabine, CL Salvador, MA Sanchez-Lugo, A Santee, ML Sasgen, I Sawaengphokhai, P Sayouri, A Scambos, TA Schauer, U Schemm, J Schlosser, P Schmid, C Schreck, C Semiletov, I Send, U Sensoy, S Setzer, A Severinghaus, J Shakhova, N Sharp, M Shiklomanov, NI Siegel, DA Silva, VBS Silva, FDS Sima, F Simeonov, P Simmonds, I Simmons, A Skansi, M Smeed, DA Smethie, WM Smith, AB Smith, C Smith, SL Smith, TM Sokolov, V Srivastava, AK Stackhouse PW Jr Stammerjohn, S Steele, M Steffen, K Steinbrecht, W Stephenson, T Su, J Svendby, T Sweet, W Takahashi, T Tanabe, RM Taylor, MA Tedesco, M Teng, WL Thepaut, JN Thiaw, WM Thoman, R Thompson, P Thorne, PW Timmermans, ML Tobin, S Toole, J Trewin, BC Trigo, RM Trotman, A Tschudi, M van de Wal, RSW Van der Werf, GR Vautard, R Vazquez, JL Vieira, G Vincent, L Vose, RS Wagner, WW Wahr, J Walsh, J Wang, JH Wang, CZ Wang, M Wang, SH Wang, L Wanninkhof, R Weaver, S Weber, M Werdell, PJ Whitewood, R Wijffels, S Wilber, AC Wild, JD Willett, KM Williams, W Willis, JK Wolken, G Wong, T Woodgate, R Worthy, D Wouters, B Wovrosh, AJ Xue, Y Yamada, R Yin, ZG Yu, LS Zhang, LY Zhang, PQ Zhao, L Zhao, J Zhong, W Ziemke, J Zimmermann, S AF Blunden, Jessica Arndt, Derek S. Achberger, Christine Ackerman, Stephen A. Albanil, Adelina Alexander, P. Alfaro, Eric J. Allan, Rob Alves, Lincoln M. Amador, Jorge A. Ambenje, Peter Andrianjafinirina, Solonomenjanahary Antonov, John Aravequia, Jose A. Arendt, A. Arevalo, Juan Ashik, I. Atheru, Zachary Banzon, Viva Baringer, Molly O. Barreira, Sandra Barriopedro, David E. Beard, Grant Becker, Andreas Behrenfeld, Michael J. Bell, Gerald D. Benedetti, Angela Bernhard, Germar Berrisford, Paul Berry, David I. Bhatt, U. Bidegain, Mario Bindoff, Nathan Bissolli, Peter Blake, Eric S. Booneeady, Raj Bosilovich, Michael Box, J. E. Boyer, Tim Braathen, Geir O. Bromwich, David H. Brown, R. Brown, L. Bruhwiler, Lori Bulygina, Olga N. Burgess, D. Burrows, John Calderon, Blanca Camargo, Suzana J. Campbell, Jayaka Cao, Y. Cappelen, J. Carrasco, Gualberto Chambers, Don P. Chang'a, L. Chappell, Petra Chehade, Wissam Cheliah, Muthuvel Christiansen, Hanne H. Christy, John R. Ciais, Phillipe Coelho, Caio A. S. Cogley, J. G. Colwell, Steve Cross, J. N. Crouch, Jake Cunningham, Stuart A. Dacic, Milan De Jeu, Richard A. M. Dekaa, Francis S. Demircan, Mesut Derksen, C. Diamond, Howard J. Dlugokencky, Ed J. Dohan, Kathleen Dolman, A. Johannes Domingues, Catia M. Dong Shenfu Dorigo, Wouter A. Drozdov, D. S. Duguay, Claude R. Dunn, Robert J. H. Duran-Quesada, Ana M. Dutton, Geoff S. Ehmann, Christian Elkins, James W. Euscategui, Christian Famiglietti, James S. Fang Fan Fauchereau, Nicolas Feely, Richard A. Fekete, Balazs M. Fenimore, Chris Fioletov, Vitali E. Fogarty, Chris T. Fogt, Ryan L. Folland, Chris K. Foster, Michael J. Frajka-Williams, Eleanor Franz, Bryan A. Frith, Stacey H. Frolov, I. Ganter, Catherine Garzoli, Silvia Geai, M.-L. Gerland, S. Gitau, Wilson Gleason, Karin L. Gobron, Nadine Goldenberg, Stanley B. Goni, Gustavo Good, Simon A. Gottschalck, Jonathan Gregg, Margarita C. Griffiths, Georgina Grooss, Jens-Uwe Guard, Charles 'Chip' Gupta, Shashi K. Hall, Bradley D. Halpert, Michael S. Harada, Yayoi Hauri, C. Heidinger, Andrew K. Heikkila, Anu Heim, Richard R., Jr. Heimbach, Patrick Hidalgo, Hugo G. Hilburn, Kyle Ho, Shu-peng (Ben) Hobbs, Will R. Holgate, Simon Hovsepyan, Anahit Hu Zeng-Zhen Hughes, P. Hurst, Dale F. Ingvaldsen, R. Inness, Antje Jaimes, Ena Jakobsson, Martin James, Adamu I. Jeffries, Martin O. Johns, William E. Johnsen, Bjorn Johnson, Gregory C. Johnson, Bryan Jones, Luke T. Jumaux, Guillaume Kabidi, Khadija Kaiser, Johannes W. Kamga, Andre Kang, Kyun-Kuk Kanzow, Torsten O. Kao, Hsun-Ying Keller, Linda M. Kennedy, John J. Key, J. Khatiwala, Samar Pour, H. Kheyrollah Kholodov, A. L. Khoshkam, Mahbobeh Kijazi, Agnes Kikuchi, T. Kim, B.-M. Kim, S.-J. Kimberlain, Todd B. Knaff, John A. Korshunova, Natalia N. Koskela, T. Kousky, Vernon E. Kramarova, Natalya Kratz, David P. Krishfield, R. Kruger, Andries Kruk, Michael C. Kumar, Arun Lagerloef, Gary S. E. Lakkala, K. Lander, Mark A. Landsea, Chris W. Lankhorst, Matthias Laurila, T. Lazzara, Matthew A. Lee, Craig Leuliette, Eric Levitus, Sydney L'Heureux, Michelle Lieser, Jan Lin, I-I Liu, Y. Y. Liu, Y. Liu Hongxing Liu Yanju Lobato-Sanchez, Rene Locarnini, Ricardo Loeb, Norman G. Loeng, H. Long, Craig S. Lorrey, Andrew M. Luhunga, P. Lumpkin, Rick Luo Jing-Jia Lyman, John M. Macdonald, Alison M. Maddux, Brent C. Malekela, C. Manney, Gloria Marchenko, S. S. Marengo, Jose A. Marotzke, Jochem Marra, John J. Martinez-Gueingla, Rodney Massom, Robert A. Mathis, Jeremy T. McBride, Charlotte McCarthy, Gerard McVicar, Tim R. Mears, Carl Meier, W. Meinen, Christopher S. Menendez, Melisa Merrifield, Mark A. Mitchard, Edward Mitchum, Gary T. Montzka, Stephen A. Morcrette, Jean-Jacques Mote, Thomas Muehle, Jens Muehr, Bernhard Mullan, A. Brett Mueller, Rolf Nash, Eric R. Nerem, R. Steven Newlin, Michele L. Newman, Paul A. Ng'ongolo, H. Nieto, Juan Jose Nishino, S. Nitsche, Helga Noetzli, Jeannette Oberman, N. G. Obregon, Andre' Ogallo, Laban A. Oludhe, Christopher S. Omar, Mohamed I Overland, James Oyunjargal, Lamjav Parinussa, Robert M. Park, Geun-Ha Park, E-Hyung Parker, David Pasch, Richard J. Pascual-Ramirez, Reynaldo Pelto, Mauri S. Penalba, Olga Peng, L. Perovich, Don K. Pezza, Alexandre B. Phillips, David Pickart, R. Pinty, Bernard Pitts, Michael C. Purkey, Sarah G. Quegan, Shaun Quintana, Juan Rabe, B. Rahimzadeh, Fatemeh Raholijao, Nirivololona Raiva, I. Rajeevan, Madhavan Ramiandrisoa, Voahanginirina Ramos, Alexandre Ranivoarissoa, Sahondra Rayner, Nick A. Rayner, Darren Razuveav, Vyacheslav N. Reagan, James Reid, Phillip Renwick, James Revedekar, Jayashree Richter-Menge, Jacqueline Rivera, Ingrid L. Robinson, David A. Rodell, Matthew Romanovsky, Vladimir E. Ronchail, Josyane Rosenlof, Karen H. Sabine, Christopher L. Salvador, Mozar A. Sanchez-Lugo, Ahira Santee, Michelle L. Sasgen, I. Sawaengphokhai, P. Sayouri, Amal Scambos, Ted A. Schauer, U. Schemm, Jae Schlosser, P. Schmid, Claudia Schreck, Carl Semiletov, Igor Send, Uwe Sensoy, Serhat Setzer, Alberto Severinghaus, Jeffrey Shakhova, Natalia Sharp, M. Shiklomanov, Nicolai I. Siegel, David A. Silva, Viviane B. S. Silva, Frabricio D. S. Sima, Fatou Simeonov, Petio Simmonds, I. Simmons, Adrian Skansi, Maria Smeed, David A. Smethie, W. M. Smith, Adam B. Smith, Cathy Smith, Sharon L. Smith, Thomas M. Sokolov, V. Srivastava, A. K. Stackhouse, Paul W., Jr. Stammerjohn, Sharon Steele, M. Steffen, Konrad Steinbrecht, Wolfgang Stephenson, Tannecia Su, J. Svendby, T. Sweet, William Takahashi, Taro Tanabe, Raymond M. Taylor, Michael A. Tedesco, Marco Teng, William L. Thepaut, Jean-Noel Thiaw, Wassila M. Thoman, R. Thompson, Philip Thorne, Peter W. Timmermans, M.-L. Tobin, Skie Toole, J. Trewin, Blair C. Trigo, Ricardo M. Trotman, Adrian Tschudi, M. van de Wal, Roderik S. W. Van der Werf, Guido R. Vautard, Robert Vazquez, J. L. Vieira, Goncalo Vincent, Lucie Vose, Russ S. Wagner, Wolfgang W. Wahr, John Walsh, J. Wang Junhong Wang Chunzai Wang, M. Wang Sheng-Hung Wang Lei Wanninkhof, Rik Weaver, Scott Weber, Mark Werdell, P. Jeremy Whitewood, Robert Wijffels, Susan Wilber, Anne C. Wild, J. D. Willett, Kate M. Williams, W. Willis, Joshua K. Wolken, G. Wong, Takmeng Woodgate, R. Worthy, D. Wouters, B. Wovrosh, Alex J. Xue Yan Yamada, Ryuji Yin Zungang Yu Lisan Zhang Liangying Zhang Peiqun Zhao Lin Zhao, J. Zhong, W. Ziemke, Jerry Zimmermann, S. TI State of the Climate in 2012 SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID SEA-SURFACE-TEMPERATURE; MADDEN-JULIAN OSCILLATION; WESTERN NORTH PACIFIC; INTERNATIONAL POLAR YEAR; COUPLED KELVIN WAVES; MERIDIONAL OVERTURNING CIRCULATION; OUTGOING LONGWAVE RADIATION; CALIFORNIA CURRENT SYSTEM; OCEAN THERMAL STRUCTURE; GLOBAL WATER CYCLE AB For the first time in serveral years, the El Nino-Southern Oscillation did not dominate regional climate conditions around the globe. A weak La Ni a dissipated to ENSOneutral conditions by spring, and while El Nino appeared to be emerging during summer, this phase never fully developed as sea surface temperatures in the eastern conditions. Nevertheless, other large-scale climate patterns and extreme weather events impacted various regions during the year. A negative phase of the Arctic Oscillation from mid-January to early February contributed to frigid conditions in parts of northern Africa, eastern Europe, and western Asia. A lack of rain during the 2012 wet season led to the worst drought in at least the past three decades for northeastern Brazil. Central North America also experienced one of its most severe droughts on record. The Caribbean observed a very wet dry season and it was the Sahel's wettest rainy season in 50 years. Overall, the 2012 average temperature across global land and ocean surfaces ranked among the 10 warmest years on record. The global land surface temperature alone was also among the 10 warmest on record. In the upper atmosphere, the average stratospheric temperature was record or near-record cold, depending on the dataset. After a 30-year warming trend from 1970 to 1999 for global sea surface temperatures, the period 2000-12 had little further trend. This may be linked to the prevalence of La Ni a-like conditions during the 21st century. Heat content in the upper 700 m of the ocean remained near record high levels in 2012. Net increases from 2011 to 2012 were observed at 700-m to 2000-m depth and even in the abyssal ocean below. Following sharp decreases in to the effects of La Ni a, sea levels rebounded to reach records highs in 2012. The increased hydrological cycle seen in recent years continued, with more evaporation in drier locations and more precipitation in rainy areas. In a pattern that has held since 2004, salty areas of the ocean surfaces and subsurfaces were anomalously salty on average, while fresher areas were anomalously fresh. Global tropical cyclone activity during 2012 was near average, with a total of 84 storms compared with the 1981-2010 average of 89. Similar to 2010 and 2011, the North Atlantic was the only hurricane basin that experienced above-normal activity. In this basin, Sandy brought devastation to Cuba and parts of the eastern North American seaboard. All other basins experienced either near-or below-normal tropical cyclone activity. Only three tropical cyclones reached Category 5 intensity-all in Bopha became the only storm in the historical record to produce winds greater than 130 kt south of 7 N. It was also the costliest storm to affect the Philippines and killed more than 1000 residents. Minimum Arctic sea ice extent in September and Northern Hemisphere snow cover extent in June both reached new record lows. June snow cover extent is now declining at a faster rate (-17.6% per decade) than September sea ice extent (-13.0% per decade). Permafrost temperatures reached record high values in northernmost Alaska. A new melt extent record occurred on 11-12 July on the Greenland ice sheet; 97% of the ice sheet showed some form of melt, four times greater than the average melt for this time of year. The climate in Antarctica was relatively stable overall. The largest maximum sea ice extent since records begain in 1978 was observed in September 2012. In the stratosphere, warm air led to the second smallest ozone hole in the past two decades. Even so, the springtime ozone layer above Antarctica likely will not return to its early 1980s state until about 2060. Following a slight decline associated with the global 2 emissions from fossil fuel combustion and cement production reached a record 9.5 +/- 0.5 Pg C in 2011 and a new record of 9.7 +/- 0.5 Pg C is estimated for 2012. Atmospheric CO2 concentrations increased by 2.1 ppm in 2012, to 392.6 ppm. In spring 2012, 2 concentration exceeded 400 ppm at 7 of the 13 Arctic observation sites. Globally, other greenhouse gases including methane and nitrous oxide also continued to rise in concentration and the combined effect now represents a 32% increase in radiative forcing over a 1990 baseline. Concentrations of most ozone depleting substances continued to fall. C1 [Achberger, Christine] Univ Gothenburg, Dept Earth Sci, Gothenburg, Sweden. [Ackerman, Stephen A.; Foster, Michael J.; Heidinger, Andrew K.; Liu, Y.; Pascual-Ramirez, Reynaldo] Univ Wisconsin, Cooperat Inst Meteorol Satellite Studies, Madison, WI USA. [Albanil, Adelina; Lobato-Sanchez, Rene; Vazquez, J. L.] Natl Meteorol Serv Mexico, Mexico City, DF, Mexico. [Alexander, P.; Tedesco, Marco] CUNY City Coll, Dept Earth & Atmospher Sci, New York, NY USA. 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[Barreira, Sandra] Argentine Naval Hydrog Serv, Buenos Aires, DF, Argentina. [Barriopedro, David E.] UCM, Madrid, Spain. [Beard, Grant; Ganter, Catherine; Obregon, Andre'] Bur Meteorol, Melbourne, Vic, Australia. [Becker, Andreas] Deutsch Wetterdienst DWD, Offenbach, Germany. [Behrenfeld, Michael J.] Oregon State Univ, Portland, OR USA. [Bell, Gerald D.; Gottschalck, Jonathan; Halpert, Michael S.; Hu Zeng-Zhen; Kousky, Vernon E.; Kumar, Arun; L'Heureux, Michelle; Morcrette, Jean-Jacques; Schemm, Jae; Thiaw, Wassila M.; Weaver, Scott; Wild, J. D.; Xue Yan] NOAA NWS Climate Predict Ctr, College Pk, MD USA. [Benedetti, Angela; Inness, Antje; Jones, Luke T.; Kaiser, Johannes W.; Simmons, Adrian; Thepaut, Jean-Noel] European Ctr Medium Range Weather Forecasts, Reading, Berks, England. [Bernhard, Germar] Biospher Instruments, San Diego, CA USA. [Berrisford, Paul; McCarthy, Gerard] European Ctr Medium Range Weather Forecasts, NCAS Climate, Reading, Berks, England. 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[Colwell, Steve] British Antarctic Survey, Cambridge, England. [Cross, J. N.; Hauri, C.] Univ Alaska Fairbanks, Sch Fisheries & Ocean Sci, Fairbanks, AK USA. [Cunningham, Stuart A.] Scottish Marine Inst Oban, Argyll, Scotland. [Dacic, Milan; Parinussa, Robert M.] Republ Hydrometeorol Serv Serbia, Belgrade, Serbia. [De Jeu, Richard A. M.; Dolman, A. Johannes; Van der Werf, Guido R.] Vrije Univ Amsterdam, Dept Earth Sci, Fac Earth & Life Sci, Amsterdam, Netherlands. [Dekaa, Francis S.; James, Adamu I.; Sensoy, Serhat] Nigerian Meteorol Agency, Abuja, Nigeria. [Demircan, Mesut] Turkish State Meteorol Serv, Ankara, Turkey. [Derksen, C.; Worthy, D.] Environm Canada, Climate Res Div, Toronto, ON, Canada. [Diamond, Howard J.] NOAA NESDIS Natl Climat Data Ctr, Silver Spring, MD USA. [Dohan, Kathleen; Lagerloef, Gary S. E.] Earth & Space Res, Seattle, WA USA. [Domingues, Catia M.] Antarctic Climate & Ecosyst Cooperat Res Ctr, Hobart, Tas, Australia. [Dong Shenfu; Garzoli, Silvia] Cooperat Inst Marine & Atmospher Sci, Miami, FL USA. [Dorigo, Wouter A.; Wagner, Wolfgang W.] Vienna Univ Technol, Dept Geodesy & Geoinformat, Vienna, Austria. [Drozdov, D. S.] Earth Cryosphere Inst, Tumen, Russia. [Duguay, Claude R.; Kang, Kyun-Kuk; Pour, H. Kheyrollah] Univ Waterloo, Interdisciplinary Ctr Climate Change, Waterloo, ON, Canada. [Duguay, Claude R.; Kang, Kyun-Kuk; Pour, H. Kheyrollah] Univ Waterloo, Dept Geog & Environm Management, Waterloo, ON, Canada. [Dutton, Geoff S.; Hurst, Dale F.; Wahr, John] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO USA. [Ehmann, Christian] KIT, Inst Meteorol & Climate Res IMK, Karlsruhe, Germany. [Euscategui, Christian] Inst Hidrol Meteorol & Estudios Ambientales, Bogota, Colombia. [Famiglietti, James S.] Univ Calif Irvine, Dept Earth Syst Sci, Irvine, CA USA. [Fang Fan] NASA, Goddard Earth Sci Data & Informat Serv Ctr, Greenbelt, MD USA. [Fauchereau, Nicolas] Natl Inst Water & Atmospher Res Ltd, Auckland, New Zealand. [Fauchereau, Nicolas; Overland, James] Univ Cape Town, Dept Oceanog, Rondebosch, South Africa. [Feely, Richard A.; Johnson, Gregory C.; Purkey, Sarah G.; Sabine, Christopher L.] NOAA OAR Pacific Marine Environ Lab, Seattle, WA USA. [Fekete, Balazs M.] CUNY City Coll, CUNY Environm CrossRd Initiat, New York, NY USA. [Fioletov, Vitali E.] Environm Canada, Measurements & Anal Res Sect, Toronto, ON, Canada. [Fogarty, Chris T.] Environm Canada, Canadian Hurricane Ctr, Dartmouth, NS, Canada. [Fogt, Ryan L.; Wovrosh, Alex J.] Ohio Univ, Dept Geog, Athens, OH USA. [Frajka-Williams, Eleanor] Natl Oceanog Ctr, Southampton, Hants, England. [Franz, Bryan A.; Frith, Stacey H.; Werdell, P. Jeremy; Ziemke, Jerry] NASA Goddard Space Flight Ctr, Greenbelt, MD USA. [Geai, M.-L.; Sharp, M.] Univ Alberta, Dept Earth & Atmospher Sci, Edmonton, AB, Canada. [Gerland, S.] Norwegian Polar Res Inst, Fram Ctr, Tromso, Norway. 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[Smith, Cathy] NOAA, OAR, Earth Syst Res Lab, Phys Sci Div, Boulder, CO USA. [Smith, Cathy] Climate Diagnost Ctr, Cooperat Inst Res Environm Sci, Boulder, CO USA. NOAA, NESDIS, Ctr Satellite Applicat & Res, College Pk, MD USA. [Smith, Thomas M.] Univ Maryland, Cooperat Inst Climate & Satellites, College Pk, MD USA. [Srivastava, A. K.] Indian Meteorol Dept, Pune, Maharashtra, India. [Stammerjohn, Sharon] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO USA. [Steele, M.] Univ Washington, Appl Phys Lab, Seattle, WA USA. [Steffen, Konrad] Swiss Fed Res Inst WSL, Birmensdorf, Switzerland. [Steinbrecht, Wolfgang] DWD German Weather Serv, Hohenpeissenberg, Germany. [Svendby, T.] Norwegian Inst Air Res, Kjeller, Norway. [Sweet, William] NOAA, NOS, Ctr Operat Oceanog Prod & Serv, Honolulu, HI USA. [Tanabe, Raymond M.] NOAA, NWS, Cent Pacific Hurricane Ctr, Honolulu, HI USA. [Teng, William L.] NASA, Goddard Earth Sci Data & Informat Serv Ctr ADNET, Greenbelt, MD USA. [Thoman, R.] NOAA, NWS Weather Forecast Off, Fairbanks, AK USA. [Timmermans, M.-L.] Yale Univ, New Haven, CT USA. [Tobin, Skie; Trewin, Blair C.] Australian Bur Meteorol, Melbourne, Vic, Australia. [Trotman, Adrian] Caribbean Inst Meteorol & Hydrol, Bridgetown, Barbados. [van de Wal, Roderik S. W.] Univ Utrecht, Inst Marine & Atmospher Res Utrecht, Utrecht, Netherlands. [Vieira, Goncalo] Univ Lisbon, Dept Geog, Lisbon, Portugal. [Wouters, B.] Univ Colorado, Dept Phys, Boulder, CO USA. [Wang Junhong; Zhang Liangying] NCAR, Earth Observing Lab, Boulder, CO USA. [Wang Junhong] SUNY Albany, Dept Atmospher & Environm Sci, Albany, NY USA. [Wang, M.] Univ Washington, Joint Inst Study Atmosphere & Ocean, Seattle, WA USA. [Wang Lei] LA State Univ, Dept Geog & Anthropol, Baton Rouge, LA USA. [Williams, W.; Zimmermann, S.] Fisheries & Oceans Canada, Inst Ocean Sci, Sidney, BC, Canada. [Willis, Joshua K.] CALTECH, Jet Propuls Lab, Pasadena, CA USA. [Wolken, G.] Alaska Div Geol & Geophys Surveys, Fairbanks, AK USA. [Wouters, B.] Univ Bristol, Sch Geog Sci, Bristol, Avon, England. [Yamada, Ryuji] Japan Meteorol Agcy, Tokyo Climate Ctr, Climate Predict Div, Tokyo, Japan. [Zhang Peiqun] Beijing Climate Ctr, Beijing, Peoples R China. [Zhao Lin] Cold & Arid Reg Environm & Engn Res Inst, Lanzhou, Peoples R China. RP Achberger, C (reprint author), Univ Gothenburg, Dept Earth Sci, Gothenburg, Sweden. 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Amer. Meteorol. Soc. PD AUG PY 2013 VL 94 IS 8 BP S1 EP S258 DI 10.1175/2013BAMSStateoftheClimate.1 PG 258 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 304EZ UT WOS:000330731200001 ER PT J AU Capo-Aponte, JE Hilber, DJ Urosevich, TG Lattimore, MR Weaver, JL AF Capo-Aponte, Jose E. Hilber, David J. Urosevich, Thomas G. Lattimore, Morris R. Weaver, Jeffrey L. TI Military Aircrew Eyewear Survey: Operational Issues SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE aviator spectacles; protective eyewear; Apache; HGU-4/P spectacles ID STATES-ARMY AVIATORS; UNITED-STATES; PREVALENCE AB Background: Army aircrew are required to operate under stressful conditions within a degraded visual environment. To gain an understanding of current eyewear mission needs, we surveyed aircrew regarding operational issues associated with the current U.S. Army-issue aircrew eyewear. Methods: An anonymous online survey was completed by 976 U.S. Army aircrew personnel recruited through an invitational e-mail. Results: Of the respondents, 34% reported wearing corrective lenses. Nearly 50% of them reported dissatisfaction with the HGU-4/P Aviator spectacles. The leading problems reported were discomfort (15%), "hot spots" around the ears (13%), and break of the earcup seal (11%). Nearly 41% of the respondents wore multifocal lenses and, of those, 16% reported that the HGU-4/P's restricted field of view (FOV) adversely affected duty performance. Of those who wore Modified HGU-4/P Apache spectacles, 79% had an unacceptable FOV with the helmet display unit. A similar number of aircrew modified the Apache eyewear to increase the FOV. In addition, wind and dust created eye discomfort or affected the vision of 46% of all respondents when performing flight duties. Over 82% expressed the need for an improved aircrew spectacles and 73% desired aviation-compatible protective eyewear. Discussion: The current Army HGU-4/P Aviator and the Modified HGU-4/P Apache spectacles have significant operational deficiencies and compatibility issues. Such deficiencies have led to poor wear compliance and unauthorized modification of the Army-issue Aviator eyewear, posing readiness and safety issues. The results of this survey formally identify the need for military combat eye protection that is compatible with flight systems. C1 US Army Aeromed Res Lab, Ft Rucker, AL USA. US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Capo-Aponte, JE (reprint author), Womack Army Med Ctr, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28310 USA. EM jose.e.capoaponte.mil@mail.mil FU Military Operational Medicine Research Program (MOMRP); U.S. Army Medical Research and Materiel Command FX This study was funded by the Military Operational Medicine Research Program (MOMRP), U.S. Army Medical Research and Materiel Command. NR 15 TC 2 Z9 2 U1 1 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2013 VL 84 IS 8 BP 814 EP 822 DI 10.3357/ASEM.3514.2013 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AD1LU UT WOS:000332996300006 PM 23926656 ER PT J AU Kaber, D Kaufmann, K Alexander, AL Kim, SH Naylor, JT Prinzel, LJ Pankok, C Gil, GH AF Kaber, David Kaufmann, Karl Alexander, Amy L. Kim, Sang-Hwan Naylor, James T. Prinzel, Lawrence J., III Pankok, Carl, Jr. Gil, Guk-Ho TI Testing and Validation of a Psychophysically Defined Metric of Display Clutter SO JOURNAL OF AEROSPACE INFORMATION SYSTEMS LA English DT Article ID PERFORMANCE AB Combinations of cockpit display features may lead to increased pilot perceptions of clutter. This research sought to capture pilot perceptions of display clutter associated with primary flight display features during a vertical takeoff and landing scenario and to validate a multidimensional measure of clutter previously developed for a fixed-wing environment. Sixteen active fixed-wing pilots were recruited for the study that used a simulator configured as a vertical takeoff and landing aircraft. A factor analysis was used to reduce the number of subdimensions of the clutter measure based on previous ratings data. The simplified measure revealed an increase in the number of active display features to cause an increase in perceived clutter. Displays including synthetic vision system features were perceived as significantly more cluttered than those without. Although a tunnel (highway in the sky) feature also contributed to clutter, pilots achieved higher navigation system failure detection rates when the feature was active. Significant positive correlations were found between perceived clutter and visual display properties but not between perceived clutter and performance. Although pilots rated some displays as being highly cluttered, the increased information aided navigation failure detection. Overall, the clutter measure was found to have validity and sensitivity for application across diverse flight domains. C1 [Kaber, David; Kaufmann, Karl; Pankok, Carl, Jr.; Gil, Guk-Ho] N Carolina State Univ, Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Alexander, Amy L.] Aptima Inc, Woburn, MA 01801 USA. [Kim, Sang-Hwan] Univ Michigan, Dept Ind & Syst Engn, Dearborn, MI 48128 USA. [Naylor, James T.] US Army Special Operat Command, Dept Technol Applicat Program Off, Ft Eustis, VA 23604 USA. [Prinzel, Lawrence J., III] NASA Langley Res Ctr, Hampton, VA 23666 USA. RP Kaber, D (reprint author), N Carolina State Univ, Dept Ind & Syst Engn, Campus Box 7906, Raleigh, NC 27695 USA. FU NASA Langley Research Center (LaRC) [NNL06AA21A, NNX09AN72A] FX This research was supported by NASA Langley Research Center (LaRC) under grant numbers NNL06AA21A and NNX09AN72A. The opinions and conclusions expressed in this paper are those of the authors and no do not necessarily reflect the views of NASA. This research was completed while Amy Alexander worked as a Senior Human Factors Scientist at Aptima, Inc. We thank Emily Stelzer for participation in the planning and execution of the flight simulator experiment. We also thank Trey Arthur and Steve Williams for programming the Visual Imaging Simulator for Transport Aircraft Systems computer systems to execute the flight scenario and present all display conditions. We also thank Mike Norman for flight mathematics to define the simulated craft trajectory and to model the navigation system failures. Finally, we thank Randy Bailey and Steve Young for committing NASA LaRC resources to support this project. NR 13 TC 1 Z9 1 U1 0 U2 1 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 1940-3151 EI 2327-3097 J9 J AEROSP INFORM SYST JI J. Aerosp. Inf. Syst. PD AUG PY 2013 VL 10 IS 8 BP 359 EP 368 DI 10.2514/1.I010048 PG 10 WC Engineering, Aerospace SC Engineering GA AB2GC UT WOS:000331610200001 ER PT J AU Belisle, JG Wenke, JC Krueger, CA AF Belisle, Jeffery G. Wenke, Joseph C. Krueger, Chad A. TI Return-to-duty rates among US military combat-related amputees in the global war on terror: Job description matters SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Extremity amputation; military specialty; return to duty; disability; Iraq, Afghanistan ID OPERATION ENDURING FREEDOM; CURRENT CONFLICTS; IRAQI FREEDOM; AMPUTATION; AFGHANISTAN; RECONSTRUCTION; INJURIES; OUTCOMES; WOUNDS; TRAUMA AB BACKGROUND: The purpose of this study was to identify the differences seen between military occupation services (MOS) in terms of amputation patterns, subsequent disabling conditions, and their ability to return to duty. METHODS: A retrospective study of major extremity amputations sustained by US service members between October 1, 2001, and July 30, 2011, was performed. Data obtained from the amputation database, Joint Trauma Theater Database, and the Physical Evaluation Board Liaison Office included demographics, amputation location(s), Injury Severity Scores (ISSs), disabling conditions, disability ratings, and disposition status. RESULTS: There were 1,221 major extremity amputees identified during the specified time frame, of which 899 had data regarding disabling conditions, ratings, and disposition. All service branches were represented. Personnel from the US Army (USA) Infantry were significantly (p < 0.0001) more likely to sustain an amputation than other MOS. The USA Infantry, the US Marine Corps Infantry and the USA Armor represented the top three specialties and accounted for more than 57% of all amputees. Approximately 89% of all service members did not return to duty, and the mean combined for all amputees was 76. USA Special Forces (USA SF) operators were significantly more likely to return to duty (p = 0.0022) and be found fit for duty (p = 0.0015) than all other MOS despite having a mean ISS (20) that was no different from those of other service members. No USA SF personnel were found to have posttraumatic stress disorder as a disabling condition. CONCLUSION: All amputees, regardless of MOS, are not likely to return to active duty and especially unlikely to be found fit for duty, except for members of the USA SF. The reason(s) for the increased return to duty for USA SF personnel remains unknown but a lack of posttraumatic stress disorder may be a contributing factor. (Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Belisle, Jeffery G.; Krueger, Chad A.] Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Wenke, Joseph C.] US Army Inst Surg Res, San Antonio, TX USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM cak0705@gmail.com NR 13 TC 8 Z9 8 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 IS 2 BP 279 EP 286 DI 10.1097/TA.0b013e31829bb777 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300FL UT WOS:000330449700015 PM 23887560 ER PT J AU Morrison, JJ Poon, H Rasmussen, TE Khan, MA Garner, JP AF Morrison, Jonathan James Poon, Henrietta Rasmussen, Todd E. Khan, Mansoor A. Garner, Jeffery P. TI Re: Traumatic cardiorespiratory arrest on the battlefield SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Letter C1 [Morrison, Jonathan James; Poon, Henrietta; Rasmussen, Todd E.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan James; Khan, Mansoor A.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Garner, Jeffery P.] Rotterham NHS Fdn Trust, Rotterham, England. RP Morrison, JJ (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 IS 2 BP 343 EP 344 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300FL UT WOS:000330449700026 PM 23887570 ER PT J AU Martini, WZ Dubick, MA AF Martini, Wenjun Z. Dubick, Michael A. TI Re: Coagulation and fluid resuscitation by HyperHES in severe hemorrhage SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Letter ID NATURAL COLLOID RESUSCITATION; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE; RABBITS C1 [Martini, Wenjun Z.; Dubick, Michael A.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. RP Martini, WZ (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 IS 2 BP 349 EP 349 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300FL UT WOS:000330449700036 PM 23887580 ER PT J AU Apodaca, A Olson, CM Bailey, J Butler, F Eastridge, BJ Kuncir, E AF Apodaca, Amy Olson, Chris M., Jr. Bailey, Jeffrey Butler, Frank Eastridge, Brian J. Kuncir, Eric TI Performance improvement evaluation of forward aeromedical evacuation platforms in Operation Enduring Freedom SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL DE Medical evacuation (MEDEVAC); en route care; combat trauma ID TRAUMA; CARE; BATTLEFIELD; TRISS; SCORE; DEATH AB BACKGROUND: The following three helicopter-based medical evacuation platforms operate in Southern Afghanistan: the US Army emergency medical technician (basic)-led DUSTOFF, US Air Force paramedic-led PEDRO, and UK physician-led medical emergency response team (MERT). Nearly 90% of battlefield deaths occur in the prehospital phase, comparative outcomes for these en route care platforms are unknown. The objective of this investigation was to characterize the nature of injuries in patients transported by three evacuation platforms. In addition, it aimed to compare observed versus predicted mortality among these provider groups. METHODS: A performance improvement study involving 975 coalition patients injured in Southern Afghanistan, transported from the point of injury to a military hospital, was performed. All patients were alive on admission with prehospital documentation recorded in the US Department of Defense Trauma Registry from June 2009 to June 2011. The main outcome measure was in-hospital mortality and observed versus predicted (Trauma and Injury Severity Score [TRISS]) survival were the primary end points. RESULTS: MERT transported more amputation and polytrauma casualties and included patients with higher mean Injury Severity Score (ISS) compared with PEDRO and DUSTOFF (16 [13] vs. 11 [10] and 10 [10] respectively; p < 0.001). DUSTOFF was excluded from the subgroup analysis owing to insufficient numbers of severely injured casualties with only one death. The overall mortality for MERT and PEDRO was similar (4.2% vs. 4.6%, p = 0.967). Stratifying by ISS, there was lower mortality in MERT compared with PEDRO in the range of 20 to 29 (4.8% vs. 16.2%, p = 0.021). The observed mortality among PEDRO casualties was as predicted with the exception of the range of 20 to 29, while mortality in MERT was lower than predicted for all ISS groups with greater than 10. CONCLUSION: MERT achieves greater than predicted survival, which may be related to the additional capabilities onboard. This supports the adoption of a versatile medical evacuation system with scalable crew and equipment configurations that adapt to meet the medical, tactical, and operational needs of future conflicts. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Apodaca, Amy; Bailey, Jeffrey; Butler, Frank; Eastridge, Brian J.] US Army Inst Surg Res, San Antonio, TX 78234 USA. [Olson, Chris M., Jr.] Naval Res Lab, Stennis Space Ctr, MS USA. [Kuncir, Eric] Naval Med Ctr San Diego, Dept Surg, San Diego, CA USA. RP Bailey, J (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA. EM jeffrey.a.bailey3@amedd.army.mil NR 17 TC 18 Z9 18 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S157 EP S163 DI 10.1097/TA.0b013e318299da3e PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100012 PM 23883901 ER PT J AU Corona, BT Wenke, JC Walters, TJ Rathbone, CR AF Corona, Benjamin T. Wenke, Joseph C. Walters, Thomas J. Rathbone, Christopher R. TI Intramuscular transplantation and survival of freshly isolated bone marrow cells following skeletal muscle ischemia-reperfusion injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL DE Ischemia; reperfusion; stem cell; skeletal muscle; mice ID CRITICAL LIMB ISCHEMIA; MESENCHYMAL STEM-CELLS; THERAPEUTIC ANGIOGENESIS; PROGENITOR CELLS; REGENERATION; HINDLIMB; RATS; ENGRAFTMENT; EXPRESSION; PERFUSION AB BACKGROUND: Delayed treatment cellular therapies offer an attractive means to treat extremity injuries involving acute skeletal muscle ischemia-reperfusion injury (I/R). Bone marrow is a rich source of stem and progenitor cells with the potential to improve skeletal muscle regeneration. The extent to which bone marrow cells (BMCs) may be useful for I/R is not known. The purposes of this study were twofold: (1) to evaluate BMC survival following intramuscular injection 0, 2, 7, and 14 days after injury and (2) to determine whether BMCs improve functional recovery following I/R. METHODS: Magnetic-activated cell sorting was used to isolate lineage-negative (Lin(-)) BMCs and enrich for stem and progenitor cells. To evaluate in vivo cell survival following I/R, Lin(-) BMCswere injected intramuscularly 0, 2, 7, and 14 days after I/R, and bioluminescent imaging was performed for up to 28 days after cell injections. To assess their ability to improve muscle regeneration, intramuscular injections were performed 2 days after injury, and in vivo muscle function was assessed 14 days later. RESULTS: Lin(-) BMCs survived throughout the study period regardless of the timing of delivery. Intramuscular injection of Lin(-) BMCs did not improve maximal isometric torque (300 Hz); however, both saline-injected and Lin(-) BMC-injected muscles exhibited an increase in the twitch-tetanus ratio, suggesting that damage incurred with the intramuscular injections may have had deleterious consequences for functional recovery. CONCLUSION: Although BMCs injected intramuscularly survived cell transplantation, they failed to improve muscle function following I/R. The ability of BMCs to persist in injured muscle following I/R lends to the possibility that with further development, their full potential can be realized. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Corona, Benjamin T.; Wenke, Joseph C.; Walters, Thomas J.; Rathbone, Christopher R.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX USA. RP Rathbone, CR (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA. EM christopher.r.rathbone.civ@mail.mil NR 40 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S142 EP S149 DI 10.1097/TA.0b013e31829ac1fa PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100010 PM 23883899 ER PT J AU Gerhardt, RT Koller, AR Rasmussen, TE Wright, B Lacson, E Love, P Salter, S Stewart, R Eastridge, B Epley, E Blackbourne, L AF Gerhardt, Robert T. Koller, Alexandra R. Rasmussen, Todd E. Wright, Brandi Lacson, Eleanor Love, Preston Salter, Shawn Stewart, Ronald Eastridge, Brian Epley, Eric Blackbourne, Lorne TI Analysis of remote trauma transfers in South Central Texas with comparison with current US combat operations: Results of the RemTORN-I study SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL DE Wounds and injuries; prehospital care; coagulopathy of trauma; resuscitation; military medicine ID CASUALTY CARE; MORTALITY; IRAQ; WAR AB BACKGROUND: This study aimed to analyze demographic, epidemiologic, temporal, and outcome data from an integrated trauma registry of patients undergoing initial stabilization and transfer within a mature domestic trauma network; compare data with a companion subset from the Department of Defense Trauma Registry. Texas Trauma Service Area-P is composed of 25 counties, 15 rural Level IV trauma centers (no acute care surgery), and two Level I trauma centers. METHODS: This study has a retrospective cohort design. We hypothesize that Injury Severity Scores (ISSs), time intervals, and other clinical indicators would be complimentary to contemporary combat casualties. Inclusion criteria include age 18 years to 80 years, transferred from Level IV to Level I trauma center, or expired en route. RESULTS: A total of 543 subjects (84%) met the criteria and were analyzed. Averages and confidence intervals were as follows:age of 40 years (38-41 years), males at 81%, ISS of 10 (10-11), intensive care unit stay of 2 days (1-3 days), and hospital stay of 5 days (4-6 days). Mechanisms of injury were as follows:penetrating (15%), blunt weapon (19%), stabs (9%), burns (5%), and gunshots (5%). Eight percent received blood within the first 24 hours. Survival was at 98%. Time intervals (95% confidence interval) were as follows: prehospital at 1:43 (1:29-1:58), Level IV dwell time at 3:17 (3:06-3:28), interfacility transfer at 1:43 (1:36-1:49), and total at 6:39 (6:20-6:58). RemTORN cases were older, spent longer time en route to Level I, and had ISS similar to combat casualties. Rates of blood transfusion in the first 24 hours and survival were similar in order of magnitude. CONCLUSION: The RemTORN platform is operational. Demographic, epidemiologic, and temporal characteristics as observed will support clinical investigations of traumatic coagulopathy, shock, and potential interventions before Level I arrival. Results of such investigations will likely be applicable to the contemporary and future battlefield. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Gerhardt, Robert T.] Brooke Army Med Ctr, US Army Med Dept Ctr & Sch, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert T.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Koller, Alexandra R.] Univ North Texas Med Ctr, Ft Worth, TX USA. [Rasmussen, Todd E.] US Army Inst Surg Res, Houston, TX USA. [Salter, Shawn] San Antonio Airlife Inc, San Antonio, TX USA. [Stewart, Ronald; Eastridge, Brian] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX USA. [Blackbourne, Lorne] Univ Miami, Army Trauma Training Ctr, Leonard Miller Sch Med, Miami, FL USA. RP Gerhardt, RT (reprint author), US Army US Army Inst Surg Res USAISR, 3698 Chambers Pass,Bldg 3611, San Antonio, TX 78234 USA. EM robert.gerhardt@us.army.mil NR 20 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S164 EP S168 DI 10.1097/TA.0b013e31829be079 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100013 PM 23883902 ER PT J AU Gerhardt, RT Cap, AP Cestero, R Dubick, MA Heiner, J Koller, AR Lairet, J McClinton, AR Manifold, C Stewart, R Convertino, VA Blackbourne, LH AF Gerhardt, Robert T. Cap, Andrew P. Cestero, Ramon Dubick, Michael A. Heiner, Jason Koller, Alexandra R. Lairet, Julio McClinton, Annette R. Manifold, Craig Stewart, Ronald Convertino, Victor A. Blackbourne, Lorne H. TI The Remote Trauma Outcomes Research Network: Rationale and methodology for the study of prolonged out-of-hospital transport intervals on trauma patient outcome SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID COMBAT CASUALTY CARE; DAMAGE CONTROL RESUSCITATION; EARLY COAGULOPATHY; HEMORRHAGIC-SHOCK; CURRENT WAR; MORTALITY; BATTLEFIELD; SURVIVAL; SYSTEM; DEATH C1 [Cap, Andrew P.; Dubick, Michael A.; Koller, Alexandra R.; Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX USA. [Cestero, Ramon; Stewart, Ronald] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Manifold, Craig] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Hlth Sci, San Antonio, TX 78229 USA. [Heiner, Jason] Univ Washington, Med Ctr, Div Emergency Med, Seattle, WA 98195 USA. [Koller, Alexandra R.] Univ N Texas, Med Ctr, Ft Worth, TX USA. [Lairet, Julio] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA USA. [Blackbourne, Lorne H.] Univ Miami, Leonard Miller Sch Med, Army Trauma Training Ctr, Miami, FL USA. RP Gerhardt, RT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Robert.Gerhardt@us.army.mil FU US Army Medical Research and Materiel Command [D_047_2012_USAISR]; Defense Health Program [D10_I_AR_J6_549] FX This study was supported by the US Army Medical Research and Materiel Command Grant D_047_2012_USAISR and Defense Health Program Grant D10_I_AR_J6_549. NR 34 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S137 EP S141 DI 10.1097/TA.0b013e31829bb914 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100008 PM 23883898 ER PT J AU Glassberg, E Nadler, R Rasmussen, TE Abramovich, A Erlich, T Blackbourne, LH Kreiss, Y AF Glassberg, Elon Nadler, Roy Rasmussen, Todd E. Abramovich, Amir Erlich, Tomer Blackbourne, Lorne H. Kreiss, Yitshak TI Point-of-injury use of reconstituted freeze dried plasma as a resuscitative fluid: A special report for prehospital trauma care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material DE Plasma; freeze dried plasma; prehospital; point of injury care; resuscitation fluid; trauma induced coagulopathy ID FRESH-FROZEN PLASMA; COMBAT CASUALTY CARE; BLOOD-PRODUCTS; COAGULOPATHY; TRANSFUSION; IMPACT; MORTALITY C1 [Glassberg, Elon; Nadler, Roy; Abramovich, Amir; Erlich, Tomer; Kreiss, Yitshak] Israel Def Forces, Surg Gen Headquarters, Ramat Gan, Israel. [Glassberg, Elon; Nadler, Roy; Abramovich, Amir; Erlich, Tomer; Kreiss, Yitshak] Hebrew Univ Jerusalem, Dept Mil Med, Jerusalem, Israel. [Rasmussen, Todd E.] US Army Inst Surg Res, Joint Base Ft Sam Houston, San Antonio, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Blackbourne, Lorne H.] US Army Trauma Training Ctr, Miami, FL USA. RP Glassberg, E (reprint author), Med Corps, Surg Gen Headquarters, Mil POB 02149, Israel Def Force, Israel. EM idf_trauma@idf.gov.il NR 34 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S111 EP S114 DI 10.1097/TA.0b013e318299d217 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100003 PM 23883894 ER PT J AU Hatzfeld, JJ Childs, JD Dempsey, MP Chapman, GD Lucca, JJD Brininger, T Tamminga, C Richardson, RT Alexander, S Chung, KK AF Hatzfeld, Jennifer J. Childs, John D. Dempsey, Michael P. Chapman, Gail D. Lucca, Jurandir J. Dalle Brininger, Teresa Tamminga, Cindy Richardson, Roxanne T. Alexander, Stefan Chung, Kevin K. TI Evolution of biomedical research during combat operations SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review DE Biomedical research; war; military personnel; wounds and injuries; research design ID TRAUMATIC BRAIN-INJURY AB BACKGROUND: The implementation of a human research protection program in Afghanistan and the mobilization of the combat casualty research team have made it possible to design and efficiently conduct multifaceted, multisite, and prospective research studies in a combat environment. Still, to conduct research in such an environment, several unique challenges must be overcome. METHODS: This article describes the development and conduct of three ongoing trauma-related biomedical research studies in Afghanistan, highlighting the challenges and lessons learned within the context of these studies. RESULTS: Key challenges include the process of developing and getting approval for in-theater research protocols, the informed consent process, and logistics of conducting a biomedical research study in an austere environment. Despite these challenges, important lessons learned that can contribute to the success of a protocol include the need for clear operating procedures, judicious selection for which data points must be collected in-theater, and the importance anticipating the "fog and friction" of war. CONCLUSION: As we continue the journey toward more sophisticated research capabilities in combat, this article will help inform the design and conduct of future research performed in a theater of war. Conducting biomedical research in a combat zone is an important but difficult element of military medicine. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Hatzfeld, Jennifer J.] David Grant Med Ctr, Travis AFB, CA USA. [Childs, John D.] 81st Med Grp, Keesler AFB, MS USA. [Dempsey, Michael P.] USAF Sch Aerosp Med, Wright Patterson AFB, OH USA. [Chapman, Gail D.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Tamminga, Cindy] Naval Med Res Ctr, Silver Spring, MD USA. [Tamminga, Cindy] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Lucca, Jurandir J. Dalle; Alexander, Stefan; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Brininger, Teresa] Schofield Barracks Hlth Clin, Schofield Barracks, HI USA. [Richardson, Roxanne T.] Ft Belvoir Community Hosp, Ft Belvoir, VA USA. RP Hatzfeld, JJ (reprint author), Clin Invest Facil, 101 Bodin Cir, Travis AFB, CA 94535 USA. EM jennifer.hatzfeld@gmail.com FU US Army Institute for Surgical Research; US Army MRMC IRB office FX We acknowledge LTC White, LCDR Adam, and LCDR Carr, the primary investigators of the studies described in this article, for graciously allowing us to discuss details of their protocols and their tireless efforts to contribute to the science of combat casualty care. We also appreciate the support and assistance provided by the US Army Institute for Surgical Research (Ms. Annette McClinton) and the US Army MRMC IRB office (Ms. Andrea Kline and Ms. Debra DePaul). We also thank Otilia Sanchez for proofreading and formatting the final manuscript. This article is dedicated to the combat casualties that were, and will be, enrolled into these research studies. NR 9 TC 1 Z9 1 U1 3 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S115 EP S119 DI 10.1097/TA.0b013e31829e1163 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100004 PM 23883895 ER PT J AU Klem, C Sniezek, JC Moore, B Davis, MR Coppit, G Schmalbach, C AF Klem, Christopher Sniezek, Joseph C. Moore, Brian Davis, Michael R. Coppit, George Schmalbach, Cecelia TI Microvascular reconstructive surgery in Operations Iraqi and Enduring Freedom: The US military experience performing free flaps in a combat zone SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Combat; microvascular; reconstruction; free flap; trauma ID LOWER-EXTREMITY; MICROSURGICAL RECONSTRUCTION; LOWER LEG; INJURIES; FOOT; DEFECTS; WAR; MANAGEMENT; AMPUTATION; FRACTURES AB BACKGROUND: Local nationals with complex wounds resulting from traumatic combat injuries during Operations Iraqi Freedom and Enduring Freedom usually must undergo reconstructive surgery in the combat zone. While the use of microvascular free-tissue transfer (free flaps) for traumatic reconstruction is well documented in the literature, various complicating factors exist when these intricate surgical procedures are performed in a theater of war. METHODS: The microvascular experiences of six military surgeons deployed during a 30-month period between 2006 and 2011 in Iraq and Afghanistan were retrospectively reviewed. RESULTS: Twenty-nine patients presented with complex traumatic wounds. Thirty-one free flaps were performed for the 29 patients. Location of tissue defects included the lower extremity (15), face/neck (8), upper extremity (6). Limb salvage was successful in all but one patient. Six of eight patients with head and neck wounds were tolerating oral intake at the time of discharge. There were three flap losses in 3 patients; two patients who experienced flap loss underwent a successful second free or regional flap. Minor complications occurred in six patients. CONCLUSION: Microvascular free tissue transfer for complex tissue defects in a combat zone is a critically important task and can improve quality of life for host-nation patients. Major US combat hospitals deployed to a war zone should include personnel who are trained and capable of performing these complex reconstructive procedures and who understand the many nuances of optimizing outcomes in this challenging environment. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Klem, Christopher; Sniezek, Joseph C.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Moore, Brian] Ochsner Med Ctr, New Orleans, LA USA. [Davis, Michael R.] Inst Surg Res, San Antonio, TX USA. [Coppit, George] Walter Reed Natl Med Ctr, Bethesda, MD USA. [Schmalbach, Cecelia] San Antonio Mil Med Ctr, San Antonio, TX USA. RP Klem, C (reprint author), Tripler Army Med Ctr, ATTN MCHK DSH, 100 Jarrett White Rd, Honolulu, HI 96859 USA. EM christopher.klem@us.army.mil NR 26 TC 5 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S228 EP S232 DI 10.1097/TA.0b013e318299da23 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100024 PM 23883913 ER PT J AU Lundy, JB Oh, JS Chung, KK Ritter, JL Gibb, I Nordmann, GR Sonka, BJ Tai, NRM Aden, JK Rasmussen, TE AF Lundy, Jonathan B. Oh, John S. Chung, Kevin K. Ritter, John L. Gibb, Iain Nordmann, Giles R. Sonka, Brian J. Tai, Nigel R. M. Aden, James K. Rasmussen, Todd E. TI Frequency and relevance of acute peritraumatic pulmonary thrombus diagnosed by computed tomographic imaging in combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Pulmonary embolism; combat casualties; computed tomography ID TRAUMA PATIENTS; EMBOLISM; THROMBOEMBOLISM AB BACKGROUND: Posttraumatic pulmonary embolism is historically diagnosed after clinical deterioration within the first week after injury. An increasing prevalence of immediate and asymptomatic pulmonary embolism have been reported in civilian and military trauma, termed hereafter as acute peritraumatic pulmonary thrombus (APPT). The objective of this study was to define the frequency of APPT diagnosed by computed tomographic (CT) imaging in wartime casualties. An additional objective was to identify factors, which may be associated with this radiographic finding METHODS: A 1-year retrospective cohort analysis conducted using the US and UK Joint Theater Trauma Registries performed to determine the prevalence of and risk factors for the diagnosis of APPT in casualties admitted to Bastion Hospital, Afghanistan. APPT imaging characteristics were collected, and demographics, injury severity and mechanism, and risk factors were included in the analysis. Logistic regression was used to identify factors independently associated with APPT. RESULTS: APPT was found in 66 (9.3%) of 708 consecutive trauma admissions, which received a CT chest with intravenous contrast as part of their initial evaluation. Diagnosis of APPT at the time of injury was made in 23 patients (3.2%), while thrombus was detected in 43 additional patients (6.1%) at the time of reexamination of CT images. Of the APPTs, 47% (n = 31) were central, 38% (n = 25) were segmental, and 15% (n = 10) were subsegmental. Forty-seven percent (n = 31) had bilateral APPT. Logistic regression found presence of deep venous thrombosis on admission (odds ratio, 5.75; 95% confidence interval, 2.44Y13.58; p < 0.0001) and traumatic amputation (odds ratio, 2.53; 95% confidence interval, 1.10Y5.85; p = 0.030) to be independently associated with APPT. All APPTs were felt to be incidental and likely would not have required interventions such as anticoagulation or vena caval interruption. CONCLUSION: This report is the first to characterize acute, peritraumatic pulmonary thrombus in combat injured. Nearly 1 in 10 patients with severe wartime injury has findings of pulmonary thrombus on CT imaging, although many instances require repeat examination of initial images to identify the clot. APPT is a phenomenon of severe injury and associated with deep venous thrombosis and lower-extremity traumatic amputation. Additional study is needed to characterize the natural history of peritraumatic pulmonary thrombus and the indications for anticoagulation or vena cava filter devices. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Lundy, Jonathan B.; Chung, Kevin K.; Aden, James K.; Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. [Ritter, John L.] San Antonio Mil Med Ctr, Dept Radiol, San Antonio, TX USA. [Sonka, Brian J.] William Beaumont Army Med Ctr, Dept Gen Surg, El Paso, TX 79920 USA. [Lundy, Jonathan B.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Oh, John S.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Gibb, Iain; Nordmann, Giles R.; Tai, Nigel R. M.] Minist Def, Birmingham, W Midlands, England. RP Lundy, JB (reprint author), US Army, MC, US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78236 USA. EM jonathan.b.lundy2.mil@mail.mil NR 19 TC 8 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S215 EP S220 DI 10.1097/TA.0b013e318299da66 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100022 PM 23883911 ER PT J AU Metzger, A Rees, J Segal, N McKnite, S Matsuura, T Convertino, VA Gerhardt, RT Lurie, KG AF Metzger, Anja Rees, Jennifer Segal, Nicolas McKnite, Scott Matsuura, Timothy Convertino, Victor A. Gerhardt, Robert T. Lurie, Keith G. TI "Fluidless" resuscitation with permissive hypotension via impedance threshold device therapy compared with normal saline resuscitation in a porcine model of severe hemorrhage SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhage; shock; intrathoracic pressure; impedance threshold device; permissive hypotension ID INSPIRATORY RESISTANCE; HYPOVOLEMIC PIGS; BLOOD-PRESSURE; SHOCK; SWINE; SURVIVAL; INJURY AB BACKGROUND: One approach to improve outcomes after trauma and hemorrhage is to follow the principles of permissive hypotension by avoiding intravascular overpressure and thereby preventing dislodgement of platelet plugs early in the clotting process. We hypothesized that augmentation of negative intrathoracic pressure (nITP) by treatment with an impedance threshold device would improve hemodynamics without compromising permissive hypotension or causing hemodilution, whereas aggressive fluid resuscitation with normal saline (NS) would result in hemodilution and SBPs that are too high for permissive hypotension and capable of clot dislodgement. METHODS: Thirty-four spontaneously breathing anesthetized female pigs (30.6 +/- 0.5 kg) were subjected to a fixed 55% hemorrhage over 30 minutes; block randomized to nITP, no treatment, or intravenous bolus of 1-L NS; and evaluated over 30 minutes. Results are reported as mean +/- SEM. RESULTS: Average systolic blood pressures (SBPs) (mm Hg) 30 minutes after the study interventions were as follows: nITP, 82.1 +/- 2.9; no treatment, 69.4 +/- 4.0; NS 89.3 +/- 5.2. Maximum SBPs during the initial 15 minutes of treatment were as follows: nITP, 88.0 +/- 4.3; no treatment, 70.8 +/- 4.3; and NS, 131 +/- 7.6. After 30 minutes, mean pulse pressure (mm Hg) was significantly higher in the nITP group (nITP, 32.3 +/- 2.2) versus the no-treatment group (21.5 +/- 1.5 controls) (p < 0.05), and the mean hematocrit was 25.2 +/- 0.8 in the nITP group versus 19 +/- 0.6 in the NS group (p < 0.001). CONCLUSION: In this porcine model of hemorrhagic shock, nITP therapy significantly improved SBP and pulse pressure for 30 minutes without overcompensation compared with controls with no treatment. By contrast, aggressive fluid resuscitation with NS but not nITP resulted in a significant rise in SBP to more than 100 mm Hg within minutes of initiating therapy that could cause a further reduction in hematocrit and clot dislodgment. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Metzger, Anja; Rees, Jennifer; Lurie, Keith G.] Adv Circulatory Syst Inc, Roseville, NSW, Australia. [Metzger, Anja; Segal, Nicolas; Matsuura, Timothy; Lurie, Keith G.] Univ Minnesota, Dept Emergency Med, Minneapolis, MN USA. [McKnite, Scott; Lurie, Keith G.] Minneapolis Med Res Fdn Inc, Minneapolis, MN USA. [Convertino, Victor A.; Gerhardt, Robert T.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Gerhardt, Robert T.] San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Gerhardt, Robert T.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP Metzger, A (reprint author), 1905 Cty Rd C West, Roseville, NSW 55113, Australia. EM kohl0005@umn.edu OI SEGAL M.D., Ph.D., Nicolas/0000-0002-0715-9730 FU US Army [W81XWH-10-1-0019] FX A.M. is an adjunct assistant professor in the University of Minnesota's Department of Emergency Medicine. She is also employed by Advanced Circulatory Systems Inc., the manufacturer of the ITD used in this study to provide the nITP therapy. K.G.L. is the founder and chief medical officer of Advanced Circulatory Systems, and J.R. is a research associate at Advanced Circulatory Systems. The other authors have no conflicts of interest. This study was supported by the US Army (W81XWH-10-1-0019). NR 25 TC 4 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S203 EP S209 DI 10.1097/TA.0b013e318299d5d0 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100020 PM 23883909 ER PT J AU Morrison, JJ Stannard, A Rasmussen, TE Jansen, JO Tai, NRM Midwinter, MJ AF Morrison, Jonathan J. Stannard, Adam Rasmussen, Todd E. Jansen, Jan O. Tai, Nigel R. M. Midwinter, Mark J. TI Injury pattern and mortality of noncompressible torso hemorrhage in UK combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Wartime injury; noncompressible torso hemorrhage; vascular trauma ID MAJOR LIMB TRAUMA; SEVERITY SCORE; CARE; EPIDEMIOLOGY; WOUNDS; DEATH AB BACKGROUND: Hemorrhage following traumatic injury is a leading cause of military and civilian mortality. Noncompressible torso hemorrhage (NCTH) has been identified as particularly lethal, especially in the prehospital setting. METHODS: All patients sustaining NCTH between August 2002 and July 2012 were identified from the UK Joint Theatre Trauma Registry. NCTH was defined as injury to a named torso axial vessel, pulmonary injury, solid-organ injury (Grade 4 or greater injury to the liver, kidney, or spleen) or pelvic fracture with ring disruption. Patients with ongoing hemorrhage were identified using either a systolic blood pressure of less than 90 mm Hg or the need for immediate surgical hemorrhage control. Data on injury pattern and location as well as cause of death were analyzed using univariate and multivariate analyses. RESULTS: During 10 years, 296 patients were identified with NCTH, with a mortality of 85.5%. The majority of deaths occurred before hospital admission (n = 222, 75.0%). Of patients admitted to hospital, survivors (n = 43, 14.5%) had a higher median systolic blood pressure (108 [43] vs. 89 [46], p = 0.123) and Glasgow Coma Scale (GCS) (14 [12] vs. 3 [0], p < 0.001) compared with in-hospital deaths (n = 31, 10.5%). Hemorrhage was the more common cause of death (60.1%), followed by central nervous system disruption (30.8%), total body disruption (5.1%), and multiple-organ failure (4.0%). On multivariate analysis, major arterial and pulmonary hilar injury are most lethal with odds ratio (95% confidence interval) of 16.44 (5.50-49.11) and 9.61 (1.06-87.00), respectively. CONCLUSION: This study demonstrates that the majority of patients sustaining NCTH die before hospital admission, with exsanguination and central nervous system disruption contributing to the bulk cause of death. Major arterial and pulmonary hilar injuries are independent predictors of mortality. (J Trauma Acute Care Surg. 2013; 75: S263YS268. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Morrison, Jonathan J.; Stannard, Adam; Tai, Nigel R. M.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Unit Surg, Glasgow G4 0SF, Lanark, Scotland. [Morrison, Jonathan J.; Rasmussen, Todd E.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Rasmussen, Todd E.] Sci & Technol Sect, Med Deployment Wing 59, San Antonio, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Morrison, JJ (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. EM jjmorrison@outlook.com RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 16 TC 20 Z9 21 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S263 EP S268 DI 10.1097/TA.0b013e318299da0a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100029 PM 23883918 ER PT J AU Muniz, GW Wampler, DA Manifold, CA Grudic, GZ Mulligan, J Moulton, S Gerhardt, RT Convertino, VA AF Muniz, Gary W. Wampler, David A. Manifold, Craig A. Grudic, Greg Z. Mulligan, Jane Moulton, Steven Gerhardt, Robert T. Convertino, Victor A. TI Promoting early diagnosis of hemodynamic instability during simulated hemorrhage with the use of a real-time decision-assist algorithm SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Medical monitoring; vital signs; hemorrhagic shock ID LIFESAVING INTERVENTIONS; COMBAT CASUALTIES; TRAUMA PATIENTS; BLOOD; SURVIVAL; SHOCK; PRESSURE; THERAPY AB BACKGROUND: This study aimed to test the hypothesis that the addition of a real-time decision-assist machine learning algorithm by emergency medical system personnel could shorten the time needed to identify an unstable patient during a hemorrhage profile as compared with vital sign information alone. METHODS: Fifty emergency medical team-paramedics from a large, urban fire department participated as subjects. Subjects viewed a monitor screen on two occasions as follows: (1) display of standard vital signs alone and (2) with the addition of an index (Compensatory Reserve Index) associated with estimated central blood volume status. The subjects were asked to push a computer key at any point in the sequence they believed the patient had become unstable based on information provided by the monitor screen. The average difference in time to identify hemodynamic instability between experimental and control groups was assessed by paired, two-tailed t test and reported with 95% confidence intervals (95% CI). RESULTS: The mean (SD) amount of time required to identify an unstable patient was 18.3 (4.1) minutes (95% CI, 17.2Y19.4 minutes) without the algorithm and 10.7 (4.2) minutes (95% CI, 9.5-11.9 minutes) with the algorithm (p < 0.001). CONCLUSION: In a simulated patient encounter involving uncontrolled hemorrhage, the use of a monitor that estimates central blood volume loss was associated with early identification of impending hemodynamic instability. Physiologic monitors capable of early identification and estimation of the physiologic capacity to compensate for blood loss during hemorrhage may enable optimal guidance for hypotensive resuscitation. They may also help identify casualties benefitting from forward administration of plasma, antifibrinolytics and procoagulants in a remote damage-control resuscitation model. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Muniz, Gary W.; Gerhardt, Robert T.; Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wampler, David A.; Manifold, Craig A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio Fire Dept, San Antonio, TX 78229 USA. [Wampler, David A.; Manifold, Craig A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Hlth Sci, San Antonio, TX 78229 USA. [Grudic, Greg Z.] Flashback Technol Inc, Boulder, CO USA. [Mulligan, Jane] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA. [Moulton, Steven] Univ Colorado, Sch Med, Dept Surg, Denver, CO USA. RP Convertino, VA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.a.convertino.civ@mail.mil FU US Army Medical Research and Materiel Command Combat Casualty Research Program; Small Business Innovative Research program FX This research was supported in part by funding from the US Army Medical Research and Materiel Command Combat Casualty Research Program and the Small Business Innovative Research program. Drs. Grudic and Mulligan are developers of the CRI model used in this study. Dr. Moulton is a cofounder and medical consultant to Flashback Technologies Inc. The other authors have disclosed no conflicts of interest. NR 16 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S184 EP S189 DI 10.1097/TA.0b013e31829b01db PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100017 PM 23883906 ER PT J AU Neff, LP Cannon, JW Stewart, IJ Batchinsky, AI Zonies, DH Pamplin, JC Chung, KK AF Neff, Lucas P. Cannon, Jeremy W. Stewart, Ian J. Batchinsky, Andriy I. Zonies, David H. Pamplin, Jeremy C. Chung, Kevin K. TI Extracorporeal organ support following trauma: The dawn of a new era in combat casualty critical care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID RENAL REPLACEMENT THERAPY; ACUTE KIDNEY INJURY; CARBON-DIOXIDE REMOVAL; CONTINUOUS VENOVENOUS HEMOFILTRATION; HIGH-VOLUME HEMOFILTRATION; OPERATION-IRAQI-FREEDOM; SEVERE LUNG INJURY; SEPTIC SHOCK; MEMBRANE-OXYGENATION; RESPIRATORY-FAILURE C1 [Neff, Lucas P.] David Grant Med Ctr, Travis AFB, CA 94535 USA. [Cannon, Jeremy W.; Stewart, Ian J.; Pamplin, Jeremy C.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Neff, Lucas P.; Cannon, Jeremy W.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Zonies, David H.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Batchinsky, Andriy I.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Neff, LP (reprint author), David Grant Med Ctr, 101 Bodin Circle, Travis AFB, CA 94535 USA. EM lucas.neff.2@us.af.mil NR 103 TC 7 Z9 7 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S120 EP S128 DI 10.1097/TA.0b013e318299d0cb PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100005 PM 23883896 ER PT J AU Olson, CM Bailey, J Mabry, R Rush, S Morrison, JJ Kuncir, EJ AF Olson, Chris M., Jr. Bailey, Jeffrey Mabry, Robert Rush, Stephen Morrison, Jonathan J. Kuncir, Eric J. TI Forward aeromedical evacuation: A brief history, lessons learned from the Global War on Terror, and the way forward for US policy SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID BLUNT TRAUMA; CARE; BATTLEFIELD; PHYSICIAN; IMPACT; DEATH C1 [Olson, Chris M., Jr.] Naval Res Lab, Stennis Space Ctr, MS USA. [Bailey, Jeffrey; Morrison, Jonathan J.] US Army Inst Surg Res, San Antonio, TX USA. [Mabry, Robert] San Antonio Mil Med Ctr, San Antonio, TX USA. [Rush, Stephen] USAF Pararescue, Westhampton Beach, NY USA. [Kuncir, Eric J.] Naval Med Ctr, Dept Surg, San Diego, CA USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. RP Kuncir, EJ (reprint author), Naval Med Ctr San Diego, Dept Surg, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. EM eric.kuncir@med.navy.mil OI Morrison, Jonathan/0000-0001-7462-8456 FU United States Army Institute of Surgical Research (USAISR) FX All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. There were no conflicts reported. There was no funding for this study. The United States Army Institute of Surgical Research (USAISR) supported this project. All authors are employed by the US Department of Defense. NR 28 TC 7 Z9 7 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S130 EP S136 DI 10.1097/TA.0b013e318299d189 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100007 PM 23883897 ER PT J AU Park, PK Cannon, JW Ye, W Blackbourne, LH Holcomb, JB Beninati, W Napolitano, LM AF Park, Pauline K. Cannon, Jeremy W. Ye, Wen Blackbourne, Lorne H. Holcomb, John B. Beninati, William Napolitano, Lena M. TI Transfusion strategies and development of acute respiratory distress syndrome in combat casualty care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Acute respiratory distress syndrome; transfusion ratio; plasma; crystalloid; combat casualty ID FRESH-FROZEN PLASMA; PROTHROMBIN COMPLEX CONCENTRATE; RECEIVING MASSIVE TRANSFUSIONS; DAMAGE-CONTROL RESUSCITATION; OPERATION ENDURING FREEDOM; INDEPENDENT RISK-FACTORS; ACUTE LUNG INJURY; I TRAUMA CENTER; LAST 60 YEARS; FIBRINOGEN CONCENTRATE AB BACKGROUND: Damage-control resuscitation (DCR) has been advocated to reduce mortality in military and civilian settings. However, DCR and excessive crystalloid resuscitation may be associated with a higher incidence of acute respiratory distress syndrome (ARDS). We sought to examine the impact of resuscitation strategies on ARDS development in combat casualty care. METHODS: A retrospective review of Joint Theater Trauma Registry data on US combat casualties who received at least 1 U of blood product within the first 24 hours of care was performed, cross-referenced with the cohort receiving mechanical ventilation (n = 1,475). Massive transfusion (MT, >= 10 red blood cells [RBCs] and/or whole blood in 24 hours) and volume/ratios of plasma/RBC, platelet/RBC, and crystalloid/RBC (C/RBC, crystalloid liters/RBC units) were examined using bivariate/multivariate logistic regression and local regression analyses as ARDS risk factors, controlling for age, injury severity, admission systolic blood pressure, and Glasgow Coma Scale (GCS) score. RESULTS: ARDS was identified in 95 cases (6.4%). MTwas required in 550 (37.3%) of the analysis cohort. ARDS was more common in MT (46 of 550, 8.4%) versus no-MT cohort (49 of 925, 5.3%), but mortality was not different (17.4% MT vs. 16.3% no-MT). ARDS patients received significantly increased crystalloid of blood product volumes. Increased crystalloid resuscitation (C/RBC ratio 9 1.5) occurred in 479 (32.7%) of 1,464 patients. Unadjusted mortality was significantly increased in the cohort with C/RBC ratio of 1.5 or less compared with those with greater than 1.5 (19.1% vs. 6.3%, p < 0.0001), but no difference in ARDS (6.5% vs. 6.6%) was identified. Platelet/RBC ratio did not impact on ARDS. Increasing plasma (odds ratio, 1.07; p = 0.0062) and crystalloid (odds ratio, 1.04; p = 0.041) volumes were confirmed as independent ARDS risk factors. CONCLUSION: In modern combat casualty care, increased plasma and crystalloid infusion were identified as independent risk factors for ARDS. These findings support a practice of decreased plasma/crystalloid transfusion in trauma resuscitation once hemorrhage control is established to achieve the mortality benefit of DCR and ARDS prevention. C1 [Park, Pauline K.; Napolitano, Lena M.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA. [Ye, Wen] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Cannon, Jeremy W.] Wilford Hall USAF Med Ctr, Dept Surg, San Antonio, TX USA. [Beninati, William] Wilford Hall USAF Med Ctr, San Antonio, TX USA. [Blackbourne, Lorne H.; Holcomb, John B.] US Army Inst Surg Res, San Antonio, TX USA. RP Napolitano, LM (reprint author), 1C421 Univ Hosp, Dept Surg, Div Acute Care Surg Trauma Burn Surg Crit Care Em, Box 0033,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA. EM lenan@umich.edu FU US Air Force Office of the Surgeon General, Medical Modernization Branch [FA7014-07-C-A010] FX This study was supported by the US Air Force Office of the Surgeon General, Medical Modernization Branch, under contract FA7014-07-C-A010, Log 99, BAA 07-01 (principal investigator L.M.N.). NR 45 TC 14 Z9 14 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S238 EP S246 DI 10.1097/TA.0b013e31829a8c71 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100026 PM 23883915 ER PT J AU Poon, H Morrison, JJ Clasper, JC Midwinter, MJ Jansen, JO AF Poon, Henrietta Morrison, Jonathan J. Clasper, Jon C. Midwinter, Mark J. Jansen, Jan O. TI Use and complications of operative control of arterial inflow in combat casualties with traumatic lower-extremity amputations caused by improvised explosive devices SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhage; exsanguination; arterial control; combat; trauma ID BALLOON OCCLUSION; INJURY SEVERITY; SCORE AB BACKGROUND: Proximal traumatic lower-extremity amputation has become the signature injury of the war in Afghanistan. Casualties present in extremis and often require immediate operative control of arterial inflow to prevent exsanguination. This study evaluated the use of this strategy and its complications. METHODS: This is a retrospective analysis of case notes of UK service personnel, identified from the UK Joint Theatre Trauma Registry, who sustained traumatic lower-extremity amputation requiring suprainguinal vascular control, following improvised explosive device injury in Afghanistan, between July 2008 and December 2010. RESULTS: Fifty-one casualties were identified with a median Injury Severity Score (ISS) of 30. In 10 casualties, control was obtained via an extraperitoneal approach, and in 41, control was obtained via midline laparotomy and intraperitoneal (IP) approach. The most commonly controlled vessel in extraperitoneal control was the external iliac artery, and in IP control, the common iliac artery. Within the 41 patients who had IP control, 13 also required a therapeutic laparotomy, and 9 patients had bilateral injuries at the level of the proximal femur or higher. One patient, who had undergone IP control, experienced an injury to the common iliac vein, which was repaired. There were no other immediate complications recorded, and 39 casualties survived to discharge. CONCLUSION: This is the first study to characterize the methods of proximal control in high wartime lower-extremity amputees. Although some casualties will have abdominal injuries that necessitate laparotomy, the majority in our study did not; however, in the critically ill casualty, rapid proximal control is required. Novel methods of temporary hemorrhage control may reduce the need for, and burden of, cavity surgery. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Poon, Henrietta; Morrison, Jonathan J.; Clasper, Jon C.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] US Army Inst Surg Res, San Antonio, TX USA. RP Morrison, JJ (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. EM jjmorrison@outlook.com RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 15 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S233 EP S237 DI 10.1097/TA.0b013e318299d99d PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100025 PM 23883914 ER PT J AU Pruitt, BA Rasmussen, TE AF Pruitt, Basil A., Jr. Rasmussen, Todd E. TI On the shoulders of giants ... FOREWORD SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material ID CARE C1 [Pruitt, Basil A., Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. RP Pruitt, BA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Trauma, Dept Surg, 7703 Floyd Curl Dr,MSC 7740, San Antonio, TX 78229 USA. EM pruitt@uthscsa.edu NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S107 EP S110 DI 10.1097/TA.0b013e31829fdd39 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100002 ER PT J AU Rasmussen, TE Gross, KR Baer, DG AF Rasmussen, Todd E. Gross, Kirby R. Baer, David G. TI Where do we go from here? PREFACE SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material C1 [Rasmussen, Todd E.; Gross, Kirby R.; Baer, David G.] US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.; Gross, Kirby R.; Baer, David G.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. EM todd.e.rasmussen.mil@mail.mil NR 2 TC 21 Z9 21 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S105 EP S106 DI 10.1097/TA.0b013e3182a0707b PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100001 PM 23883892 ER PT J AU Schafer, K Van Sickle, C Hinojosa-Laborde, C Convertino, VA AF Schafer, Kristin Van Sickle, Christina Hinojosa-Laborde, Carmen Convertino, Victor A. TI Physiologic mechanisms underlying the failure of the "shock index" as a tool for accurate assessment of patient status during progressive simulated hemorrhage SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Shock index; lower-body negative pressure; cardiac vagal withdrawal; baroreflex sensitivity; vital signs ID BODY NEGATIVE-PRESSURE; VAGAL BAROREFLEX; CENTRAL HYPOVOLEMIA; HEART-RATE; TOLERANCE; RESPONSES; SEQUENCES; EXERCISE; UTILITY; HUMANS AB BACKGROUND: Shock index (SI), the ratio of heart rate (HR) to systolic arterial pressure (SAP), is a metric often used to diagnose patients at risk of impending cardiovascular instability and hemorrhagic shock. We hypothesized that if SI reflected impending cardiovascular instability and shock in an individual, then: (1) elevations in SI and HR would be greater in individuals with low tolerance (LT) to progressive lower-body negative-pressure (LBNP) compared with individuals with high tolerance (HT), and (2) LT would be associated with greater vagal withdrawal of the baroreflex sensitivity (BRS) compared with HT. METHODS: A total of 187 healthy subjects (HT, 125; LT, 62) underwent exposure to LBNP until a SAP of less than 80 mm Hg (instability) was achieved. HR and SAP were used to calculate SI, and BRS was determined from spontaneous fluctuations in R-R interval and diastolic arterial pressure. Maximal cardiac vagal withdrawal was calculated as the difference between BRS at baseline and BRS at 100% LBNP tolerance. RESULTS: Contrary to our hypothesis, SI at 60%, 80%, and 100% LBNP tolerance in LT (0.59 +/- 0.03, 0.73 +/- 0.04, and 0.97 +/- 0.06, respectively) was lower (p <= 0.002) than SI in HT subjects at the same levels (0.66 +/- 0.03, 0.84 +/- 0.04, and 1.24 +/- 0.06, respectively). Maximal cardiac vagal withdrawalwas less (p = 0.045) in LT subjects (11.3 +/- 2.2 ms/mm Hg) compared with HT subjects (14.9 +/- 2.5 ms/mm Hg). The sensitivity of SI in identifying impending instability (SI, 0.9) at 80% and 100% LBNP tolerance was 13% and 63% in LT subjects and 34% and 91% in HT subjects, respectively. CONCLUSION: The low sensitivity of the SI observed in LT individuals is associated with a lower capacity to withdraw cardiac vagal activity and can lead to an undertriage of those patients most likely to develop early hemorrhagic shock. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Schafer, Kristin] United Negro Coll Fund, Fairfax, VA USA. [Van Sickle, Christina; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Convertino, VA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, San Antonio, TX 78234 USA. EM victor.a.convertino.civ@mail.mil FU US Army Medical Research and Materiel Command Combat Casualty Care Research Program FX This research was supported in part by funding from the US Army Medical Research and Materiel Command Combat Casualty Care Research Program. NR 30 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S197 EP S202 DI 10.1097/TA.0b013e31829b73aa PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100019 PM 23883908 ER PT J AU Stannard, A Morrison, JJ Sharon, DJ Eliason, JL Rasmussen, TE AF Stannard, Adam Morrison, Jonathan J. Sharon, Danny J. Eliason, Jonathan L. Rasmussen, Todd E. TI Morphometric analysis of torso arterial anatomy with implications for resuscitative aortic occlusion SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Torso vascular anatomy; endovascular measurement; CT angiography; noncompressible torso hemorrhage ID THORACOTOMY; TRAUMA; HEMORRHAGE; MANAGEMENT AB BACKGROUND: Hemorrhage is a leading cause of death in military and civilian trauma. Despite the importance of the aorta as a site of hemorrhage control and resuscitative occlusion, detailed knowledge of its morphometry is lacking. The objective of this study was to characterize aortic morphometry in a trauma population, including quantification of distances as well as and diameters and definition of relevant aortic zones. METHODS: Center line measures were made (Volume Viewer) from contrast computed tomography (CT) scans of male trauma patients (18-45 years). Aortic zones were defined based on branch arteries. Zone I includes left subclavian to celiac; Zone II includes celiac to caudal renal; Zone III includes caudal renal to aortic bifurcation. Zone lengths were calculated and correlated to a novel external measure of torso extent (symphysis pubis to sternal notch). RESULTS: Eighty-eight males (mean [SD], 28 [4] years) had CT scans for the study. The median (interquartile range) lengths (mm) of Zones I, II, and III were 210 mm (202-223 mm), 33 mm (28-38 mm), and 97 mm (91-103 mm), respectively. Median aortic diameters at the left subclavian, celiac, and lowest renal arteries were 21 mm (20-23 mm), 18 mm (16-19 mm), and 15 mm (14-16 mm), respectively, and the terminal aortic diameter was 14 mm (13-15 mm). The correlation of determination for descending aortic length (all zones) against torso extend was r = 0.454. CONCLUSION: This study provides a morphometric analysis of the aorta in a male population, demonstrating consistency of length and diameter while defining distinct axial zones. Findings suggest that center line aortic distances correlate with a simple, external measure of torso extent. Morphometric study of the aorta using CT data may facilitate the development and implementation of occlusion techniques to manage noncompressible torso, pelvic, and junctional femoral hemorrhage. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Stannard, Adam; Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. [Morrison, Jonathan J.; Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX 78234 USA. [Sharon, Danny J.] Joint Base San Antonio Lackland, Air Force Med Support Agcy, Lackland AFB, TX USA. [Eliason, Jonathan L.; Rasmussen, Todd E.] Joint Base San Antonio Lackland, Med Wing 59, Lackland AFB, TX USA. [Eliason, Jonathan L.] Univ Michigan, Div Vasc Surg, Ann Arbor, MI 48109 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Army Inst Surg Res, 3400 Rawley E Chambers Ave Suite B, San Antonio, TX 78234 USA. EM todd.rasmussen@amedd.army.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 8 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S169 EP S172 DI 10.1097/TA.0b013e31829a098d PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100014 PM 23883903 ER PT J AU Zonies, D DuBose, J Elterman, J Bruno, T Benjamin, C Cannon, J Chung, KK AF Zonies, David DuBose, Joseph Elterman, Joel Bruno, Todd Benjamin, Christian Cannon, Jeremy Chung, Kevin K. TI Early implementation of continuous renal replacement therapy optimizes casualty evacuation for combat-related acute kidney injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL DE CRRT; acute kidney injury; combat ID FAILURE; TRAUMA; RHABDOMYOLYSIS; DIALYSIS; SUPPORT; CARE AB BACKGROUND: The purpose of this report was to review the initial use and feasibility of continuous renal replacement therapy (CRRT) among combat casualties in a war zone. Although rapid evacuation to more advanced levels of care has emerged as the standard approach, life-threatening sequelae of acute kidney injury (AKI) can preclude safe patient evacuation. For the first time in US combat casualty care, a sustained, intensivist-led CRRT program was initiated during 2010 at an Air Force theater hospital. METHODS: A prospective study of consecutive US service members (USSMs) who developed combat-related renal failure and underwent CRRT at the Craig Joint Theater Hospital was undertaken. Baseline patient characteristics, indications for CRRT, laboratory values, and outcomes were evaluated. RESULTS: Nine USSMs were treated during 14-months. All were male, with a mean (SD) age of 28 (7) years and mean (SD) Injury Severity Score (ISS) of 34 (12). The dominant mechanism was blast injury (8 of 9), followed by gunshot wound (1 of 9). Most patients were Acute Kidney Injury Network (AKIN) 3 and all developed critical hyperkalemia (mean [SD], peak K+ 6.4 [0.4]). The peak plasma creatinine ranged from 1.4 mg/dL to 4.2 mg/dL (mean [SD], 3.3 [0.9] mg/dL). Patients had a mean (SD) of 17.6 [8.1] hours of CRRT before evacuation to higher echelons of care. All USSMs survived to achieve safe evacuation from the combat zone to the regional trauma center in Landstuhl, Germany (Landstuhl Regional Medical Center). Three patients died of multiorgan failure at Landstuhl Regional Medical Center. Six patients survived to undergo additional treatment in the United States. CONCLUSION: Intensivist-led CRRT is an effective therapeutic adjunct in the treatment of combat-related AKI. Provision of this extracorporeal therapy provides physiologic stabilization of casualties who might otherwise succumb to the sequelae of combat-related renal failure. These findings suggest that a self-sustaining CRRT program can be successfully implemented in combat support hospitals. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Zonies, David; Elterman, Joel] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany. [Zonies, David; Cannon, Jeremy] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Baltimore, MD USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Med, Baltimore, MD USA. [DuBose, Joseph] Univ Maryland, Ctr Shock Trauma, Baltimore C STARS, Baltimore, MD 21201 USA. [Benjamin, Christian] US Air Force Sch Aerosp Med, Dayton, OH USA. [Cannon, Jeremy] San Antonio Mil Med Ctr, San Antonio, TX USA. [Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX USA. RP Zonies, D (reprint author), Landstuhl Reg Med Ctr, CMR 402,Box 1824, AE-09180 Apo, Landstuhl, Germany. EM david.zonies2@us.af.mil NR 18 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2013 VL 75 SU 2 BP S210 EP S214 DI 10.1097/TA.0b013e318299d97a PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300JV UT WOS:000330461100021 PM 23883910 ER PT J AU Hartstein, B Gausche-Hill, M Cancio, LC AF Hartstein, Bonnie Gausche-Hill, Marianne Cancio, Leopoldo C. TI Burn Injuries in Children and the Use of Biological Dressings SO PEDIATRIC EMERGENCY CARE LA English DT Review DE burns; biological dressings; hydrocolloids ID PARTIAL-THICKNESS BURNS; SKIN SUBSTITUTES; CARBON-MONOXIDE; BIOBRANE; REPLACEMENT; MANAGEMENT AB Burns represent a significant cause of morbidity and mortality in children. In this article, a case discussion will serve as a platform for discussing the evaluation and treatment of burns in children. Use of various burn dressings such as hydrocolloids, polyurethane films, hydrogels, biosynthetic skin dressing, and biological dressings will be discussed. C1 US Army, Adelphi, MD USA. [Hartstein, Bonnie] Uniformed Serv Univ Hlth Sci, Dept Emergency Med, Brooke Army Med Ctr, San Antonio, TX USA. [Gausche-Hill, Marianne] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Gausche-Hill, Marianne] Harbor UCLA Med Ctr, Div Pediat Emergency Med, Torrance, CA 90509 USA. [Gausche-Hill, Marianne] Harbor UCLA Med Ctr, Dept Emergency Med, Torrance, CA 90509 USA. [Cancio, Leopoldo C.] US Army Inst Surg Res, US Army, Ft Sam Houston, TX USA. RP Gausche-Hill, M (reprint author), Harbor UCLA Med Ctr, Dept Emergency Med, 1000 W Carson St,Box 21, Torrance, CA 90509 USA. EM mgausche@emedharbor.edu NR 23 TC 1 Z9 1 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 EI 1535-1815 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD AUG PY 2013 VL 29 IS 8 BP 939 EP 945 PG 7 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 300NL UT WOS:000330470500016 PM 23925256 ER PT J AU Chawla, A Tolman, HL Gerald, V Spindler, D Spindler, T Alves, JHGM Cao, DG Hanson, JL Devaliere, EM AF Chawla, Arun Tolman, Hendrik L. Gerald, Vera Spindler, Deanna Spindler, Todd Alves, Jose-Henrique G. M. Cao, Degui Hanson, Jeffrey L. Devaliere, Eve-Marie TI A Multigrid Wave Forecasting Model: A New Paradigm in Operational Wave Forecasting SO WEATHER AND FORECASTING LA English DT Article ID DEEP-WATER WAVES; SEA-SURFACE; PART I; BREAKING; STRENGTH; SYSTEM; ONSET; DISSIPATION; NCEP AB A new operational wave forecasting system has been implemented at the National Centers for Environmental Prediction (NCEP) using the third public release of WAVEWATCH III. The new system uses a mosaic of grids with two-way nesting in a single model. This global system replaces a previous operational wave modeling suite (based on the second release of WAVEWATCH III). The new forecast system consists of nine grids at different resolutions to provide the National Weather Service (NWS) and NCEP centers with model guidance of suitable resolution for all areas where they have the responsibility of providing gridded forecast products. New features introduced in WAVEWATCH III, such as two-way nesting between grids and carving out selected areas of the computational domain, have allowed the operational model to increase spatial resolution and extend the global domain closer to the North Pole, while at the same time optimizing the computational cost. A spectral partitioning algorithm has been implemented to separate individual sea states from the overall spectrum, thus providing additional products for multiple sea states. Field output data are now packed in version 2 of the gridded binary (GRIB2) format and apart from the standard mean wave parameters, they also include parameters of partitioned wave spectra. The partitioning is currently limited to three fields: the wind-wave component, and primary and secondary swells. The modeling system has been validated against data using a multiyear hindcast database as well as archived forecasts. Anew software tool developed by the U. S. Army Corps of Engineers (USACE) is used to extend the analysis from overall error estimates to separate skill scores for wind seas and swells. C1 [Chawla, Arun; Tolman, Hendrik L.; Gerald, Vera] NOAA, NCEP, College Pk, MD USA. [Spindler, Deanna; Spindler, Todd] NOAA, NCEP, IMSG, Rockville, MD USA. [Alves, Jose-Henrique G. M.] NOAA, NCEP, SRG, Camp Springs, MD USA. [Cao, Degui] NOAA, NCEP, SAIC, Greenbelt, MD USA. [Hanson, Jeffrey L.; Devaliere, Eve-Marie] USACE Field Res Facil, Kitty Hawk, NC USA. RP Chawla, A (reprint author), NOAA, NCEP, 5200 Auth Rd, Camp Springs, MD 20746 USA. EM arun.chawla@noaa.gov NR 49 TC 6 Z9 7 U1 0 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0882-8156 EI 1520-0434 J9 WEATHER FORECAST JI Weather Forecast. PD AUG PY 2013 VL 28 IS 4 BP 1057 EP 1078 DI 10.1175/WAF-D-12-00007.1 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 301LB UT WOS:000330532700008 ER PT J AU Holfeld, J Zimpfer, D Albrecht-Schgoer, K Stojadinovic, A Paulus, P Thomas, A Schaden, W Kirchmair, R Aharinejad, S Grimm, M AF Holfeld, J. Zimpfer, D. Albrecht-Schgoer, K. Stojadinovic, A. Paulus, P. Thomas, A. Schaden, W. Kirchmair, R. Aharinejad, S. Grimm, M. TI Direct epicardial shock wave therapy improves ventricular function in a porcine model of ischemic heart disease: evidence for induction of angiogenesis and stimulation of VEGF receptors SO EUROPEAN HEART JOURNAL LA English DT Meeting Abstract CT Congress of the European-Society-of-Cardiology (ESC) CY AUG 31-SEP 04, 2013 CL Amsterdam, NETHERLANDS SP European Soc Cardiol C1 [Holfeld, J.; Grimm, M.] Med Univ Innsbruck, Dept Cardiac Surg, A-6020 Innsbruck, Austria. [Zimpfer, D.; Thomas, A.; Aharinejad, S.] Med Univ Vienna, Dept Cardiac Surg, Vienna, Austria. [Albrecht-Schgoer, K.; Kirchmair, R.] Med Univ Innsbruck, Dept Internal Med 1, A-6020 Innsbruck, Austria. [Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Paulus, P.] Johann Wolfgang Goethe Univ Hosp, Frankfurt, Germany. [Schaden, W.] AUVA Trauma Ctr Meidling, Vienna, Austria. NR 0 TC 0 Z9 0 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0195-668X EI 1522-9645 J9 EUR HEART J JI Eur. Heart J. PD AUG PY 2013 VL 34 SU 1 BP 1054 EP 1055 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 262OH UT WOS:000327744606394 ER PT J AU Valisetty, RR Dongare, AM Rajendran, AM Namburu, RR AF Valisetty, R. R. Dongare, A. M. Rajendran, A. M. Namburu, R. R. TI Effect of the Strain Rate and Microstructure on Damage Growth in Aluminum SO CMC-COMPUTERS MATERIALS & CONTINUA LA English DT Article DE Nanocrystalline metals; Molecular dynamics; Voids; Dynamic failure ID VOID-GROWTH; DISLOCATION NUCLEATION; DUCTILE FRACTURE; DYNAMIC FAILURE; YIELD CRITERIA; SPALL STRENGTH; METALS; CU; INDENTATION; SIMULATION AB Materials used in soldier protective structures, such as armor, vehicles and civil infrastructures, are being improved for performance in extreme dynamic environments. Nanocrystalline metals show significant promise in the design of these structures with superior strengths attributed to the dislocation-based and grain-boundary-based processes as compared to their polycrystalline counter-parts. An optimization of these materials, however, requires a fundamental understanding of damage evolution at the atomic level. Accordingly, atomistic molecular dynamics simulations are performed using an embedded-atom method (EAM) potential on three nano-crystalline aluminum atom systems, one a Voronoi-based nano-crystalline system with an average grain size of 10 nm, and the other two single crystals. These simulations are performed under the condition of uniaxial expansion at several strain rates ranging from 10(6) s(-1) to 10(10) s(-1). Results for the effective stress are discussed with the aim of establishing the role of the strain rate and microstructure on the evolution of the plastic strain and void volume fraction and the eventual loss of stress carrying capability of the atom systems. C1 [Valisetty, R. R.; Namburu, R. R.] Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dongare, A. M.] Univ Connecticut, Dept Chem Mat & Biomol Engg, Storrs, CT 06269 USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. RP Valisetty, RR (reprint author), Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. EM ramakrishna.r.valisetty.civ@mail.mil; dongare@uconn.edu OI Dongare, Avinash/0000-0003-3189-3588 NR 43 TC 1 Z9 1 U1 1 U2 15 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1546-2218 EI 1546-2226 J9 CMC-COMPUT MATER CON JI CMC-Comput. Mat. Contin. PD AUG PY 2013 VL 36 IS 3 BP 231 EP 255 PG 25 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Materials Science; Mathematics GA 261RT UT WOS:000327683000001 ER PT J AU Ahmed, FA Kamnaksh, A Kovesdi, E Long, JB Agoston, DV AF Ahmed, Farid A. Kamnaksh, Alaa Kovesdi, Erzsebet Long, Joseph B. Agoston, Denes V. TI Long-term consequences of single and multiple mild blast exposure on select physiological parameters and blood-based biomarkers SO ELECTROPHORESIS LA English DT Article DE Animal models; Brain trauma; Experimental; Physiology; Proteomics ID TRAUMATIC BRAIN-INJURY; CONCUSSION; RATS AB Mild traumatic brain injury (mTBI), especially when it is repeated (rmTBI), can lead to progressive degenerative diseases and lasting neuropsychiatric abnormalities. To better understand the long-term pathobiological changes in mTBI and rmTBI, we exposed rats to single or repeated (5 total; administered on consecutive days) mild blast overpressure, monitored changes in physiological parameters, and determined the plasma levels of select biomarkers at 42 days post injury by proteomics. We unexpectedly found comparable changes in arterial oxygen saturation levels and heart rates of single-injured (SI) and multiple-injured (MI) rats throughout the observation period. Our analyses indicated lasting oxidative stress, vascular abnormalities, and neuronal and glial cell loss in both injured groups. However, MI rats exhibited a relatively more pronounced increase in the plasma levels of most of the tested markers-particularly those associated with inflammation-albeit the differences between the two injured groups were not statistically significant. Our findings indicate that the frequency of blast exposures is an important determinant of the resulting cumulative damage in rmTBI. C1 [Ahmed, Farid A.; Kamnaksh, Alaa; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Ahmed, Farid A.; Kamnaksh, Alaa; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Kovesdi, Erzsebet] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC USA. [Long, Joseph B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Agoston, DV (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM vagoston@usuhs.edu FU Center for Neuroscience and Regenerative Medicine [G1703F] FX We thank the Neurotrauma Team at the Walter Reed Army Institute of Research for their technical help during the exposures. This work was supported by the Center for Neuroscience and Regenerative Medicine grant number G1703F. The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official position, policy, or decision of the Department of the Army or the Department of Defense. The authors have no financial disclosures. Animal handling and treatments were conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations related to animals and experiments involving animals, and adhered to principles stated in the Guide to the Care and Use of Laboratory Animals, National Research Council. The facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 18 TC 13 Z9 14 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0173-0835 EI 1522-2683 J9 ELECTROPHORESIS JI Electrophoresis PD AUG PY 2013 VL 34 IS 15 BP 2229 EP 2233 DI 10.1002/elps.201300077 PG 5 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 261KJ UT WOS:000327663600012 PM 23712899 ER PT J AU Zheng, BL Li, Y Xu, WZ Zhou, YZ Mathaudhu, SN Zhu, YT Lavernia, EJ AF Zheng, Baolong Li, Ying Xu, Weizong Zhou, Yizhang Mathaudhu, Suveen N. Zhu, Yuntian Lavernia, Enrique J. TI Twinning in cryomilled nanocrystalline Mg powder SO PHILOSOPHICAL MAGAZINE LETTERS LA English DT Article DE twinning; magnesium; nanocrystalline; cryomilling ID HIGH-PRESSURE TORSION; DEFORMATION TWINS; SINGLE-CRYSTALS; ALLOY; AL; METALS; MAGNESIUM; MECHANISMS; STRENGTH; SLIP AB Nanocrystalline (nc) Mg powder was synthesized via cryomilling. Extension twins were identified with high-resolution transmission electron microscopy in the cryomilled powders and the study presents the first evidence of twinning in unalloyed nc Mg. The formation of twins in the nc Mg is attributed to a high strain rate, the low (cryogenic) temperature and high local shear stresses present around the grain boundaries during deformation by cryomilling. C1 [Zheng, Baolong; Zhou, Yizhang; Lavernia, Enrique J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Li, Ying] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Xu, Weizong; Zhu, Yuntian] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mathaudhu, Suveen N.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. EM lavernia@ucdavis.edu RI Zhu, Yuntian/B-3021-2008; Xu, Weizong/G-3328-2014; Li, Ying/G-3908-2010; Mathaudhu, Suveen/B-4192-2009 OI Zhu, Yuntian/0000-0002-5961-7422; Xu, Weizong/0000-0003-0030-8606; Li, Ying/0000-0003-3738-9307; FU US Army Research Office [W911NF-10-1-0512] FX The authors acknowledge the financial support provided by the US Army Research Office (Grant No W911NF-10-1-0512). The authors would like to express their appreciation to Professor S. Mahajan for constructive discussion and suggestions. NR 35 TC 2 Z9 2 U1 5 U2 20 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0839 EI 1362-3036 J9 PHIL MAG LETT JI Philos. Mag. Lett. PD AUG 1 PY 2013 VL 93 IS 8 BP 457 EP 464 DI 10.1080/09500839.2013.801567 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA 263XF UT WOS:000327840600003 ER PT J AU Biss, MM AF Biss, Matthew M. TI Energetic Material Detonation Characterization: A Laboratory-Scale Approach SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Detonation; Air blast; Shock wave; Laboratory scale; Spherical charges ID EXPLOSIVES; PRESSURE AB A novel energetic-material detonation and air-blast characterization technique is proposed through the use of a laboratory-scale-based modified aquarium test. A streak camera is used to record the radial shock wave expansion rate at the energetic materialair interface of spherical laboratory-scale (i.e., gram-range) charges detonated in air. A linear regression fit is applied to the measured streak record data. Using this in conjunction with the conservation laws, material Hugoniots, and two empirically established relationships, a procedure is developed to determine fundamental detonation properties (pressure, velocity, particle velocity, and density) and air shock wave properties (pressure, velocity, particle velocity, and density) at the energetic materialair interface. The experimentally determined properties are in good agreement with published values. The theory's applicability is extended using historical experimental test data due to the limited number of experiments able to be performed. Predicted detonation wave and air shock wave properties are in good agreement for a multitude of energetics across various atmospheric conditions. C1 US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. RP Biss, MM (reprint author), US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM matthew.m.biss.civ@mail.mil FU U.S. Army Research Laboratory's Lethality Division Innovation Program; National Research Council FX I would like to acknowledge the U.S. Army Research Laboratory's Lethality Division Innovation Program and the National Research Council Postdoctoral Fellowship Program for funding of this research. I am greatly appreciative to Dr. Thuvan Piehler, Dr. Larry Van de Kieft, Mr. Gerrit Sutherland, and Mr. Vincent Boyle for their thoughtful discussions, Mr. Roy Maulbetsch, Mr. Terry Piatt, and Mrs. Lori Pridgeon for pressing of the energetic samples, and to technicians Mr. Ronnie Thompson, Mr. William Sickels, Mr. Richard Benjamin, Mr. Ray Sparks, and Mr. Gene Summers for their assistance in conducting these experiments. NR 21 TC 2 Z9 2 U1 2 U2 12 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2013 VL 38 IS 4 BP 477 EP 485 DI 10.1002/prep.201300013 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 261KS UT WOS:000327664500002 ER PT J AU Anderson, PE Cook, P Davis, A Mychajlonka, K AF Anderson, Paul E. Cook, Paula Davis, Andy Mychajlonka, Kyle TI The Effect of Binder Systems on Early Aluminum Reaction in Detonations SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Detonation calorimetry; Aluminum; Oxygen balance AB The objective of this study was to determine compositional variables that result in early reaction of aluminum in detonations of pressed high explosive compositions, defined as reaction by 7 volume expansions as measured by 2.54cm diameter copper cylinder expansion tests. In order to accomplish this in an economical fashion, statistical mixture design of experiments (DOE) was used in conjunction with anaerobic detonation calorimetry. The effect of binder type (e.g. energetic vs. inert), binder content, HMX content, aluminum content, and aluminum particle size was investigated. It was determined an energetic binder must be used to obtain significant aluminum reaction at volume expansions less than 7V/V-0. Aluminum particle size was only a minor factor. Furthermore, the compositional oxygen balance only provides a general indication of which compositions exhibit more aluminum reaction than others. C1 [Anderson, Paul E.; Cook, Paula] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Davis, Andy; Mychajlonka, Kyle] Nammo Talley, Mesa, AZ 85024 USA. RP Anderson, PE (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM paul.e.anderson64.civ@mail.mil FU Nammo Talley IRD; STAR Army Technology Objective FX The authors wish to thank Nammo Talley IR&D and the STAR Army Technology Objective for funding this work. Thanks to Dr. Ernie Baker and Mrs. Wendy Balas-Hummers for their guidance and discussions. NR 12 TC 3 Z9 4 U1 0 U2 3 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2013 VL 38 IS 4 BP 486 EP 494 DI 10.1002/prep.201200104 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 261KS UT WOS:000327664500003 ER PT J AU Fernandez, DA Louzao, MC Vilarino, N Espina, B Fraga, M Vieytes, MR Roman, A Poli, M Botana, LM AF Fernandez, Diego A. Carmen Louzao, M. Vilarino, Natalia Espina, Begona Fraga, Maria Vieytes, Mercedes R. Roman, Albina Poli, Mark Botana, Luis M. TI The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity SO FEBS JOURNAL LA English DT Article DE Caco-2; intestinal permeability; occludin; palytoxin; trans-epithelial electric resistance ID TIGHT-JUNCTION STRUCTURE; OSTREOPSIS CF. OVATA; OF-THE-ART; IN-VITRO; MARINE TOXINS; NEUROBLASTOMA-CELLS; PUTATIVE PALYTOXIN; OVATOXIN-A; CYTOSKELETON; CYTOTOXICITY AB Palytoxin is one of the most toxic marine toxins known. Distributed worldwide, it poses a potential human health risk linked to the consumption of contaminated seafood. Despite its high parenteral toxicity, the lethal oral dose of palytoxin is several times higher than the intraperitoneal lethal dose. In the present study, we investigated the passage of palytoxin through the human intestinal barrier by employing a well-characterized and accepted in vitro model of intestinal permeability that uses differentiated Caco-2 cell monolayers. Trans-epithelial electric resistance measurements showed that palytoxin disrupts the integrity of Caco-2 monolayers at concentrations > 0.135 nM. However, confocal microscopy imaging showed that the tight-junction protein occludin was not affected by palytoxin in the nanomolar range. This finding was supported by transmission electron microscopy imaging, where tight-junctions appeared to be unaffected by palytoxin treatment. In addition, the nuclear envelope does not appear to be altered by high concentrations of palytoxin. However, palytoxin-treated cells showed electron-dense and damaged mitochondria. Toxin exposure also induced the disappearance of the differentiated Caco-2 microvilli and organelles, as well as chromatin de-condensation. Permeability assays showed that palytoxin could not significantly pass the Caco-2 monolayer, despite the lack of epithelium integrity, suggesting that palytoxins would be poorly transported to blood, which may explain its lower oral toxicity. These data can help to achieve a better understanding of palytoxin poisoning. However, more studies regarding its repeated administration and chronic effects are needed. C1 [Fernandez, Diego A.; Carmen Louzao, M.; Vilarino, Natalia; Espina, Begona; Fraga, Maria; Botana, Luis M.] Univ Santiago de Compostela, Fac Vet, Dept Farmacol, Lugo 27002, Spain. [Espina, Begona] Int Iberian Nanotechnol Lab INL, Braga, Portugal. [Vieytes, Mercedes R.] Univ Santiago de Compostela, Fac Vet, Dept Fisiol Anim, Lugo 27002, Spain. [Roman, Albina] Unidad Microscopia Elect & Confocal, Lugo, Spain. [Poli, Mark] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. RP Botana, LM (reprint author), Univ Santiago de Compostela, Fac Vet, Dept Farmacol, Campus Univ, Lugo 27002, Spain. EM mcarmen.louzao@usc.es; luis.botana@usc.es RI Fernandez Martinez, Diego Alberto/A-7663-2011; Espina, Begona/H-1723-2014; INL, Citations/K-3436-2015; OI Fernandez Martinez, Diego Alberto/0000-0002-3336-5036; Espina, Begona/0000-0002-7645-2834; INL, Citations/0000-0002-3745-5100; Botana, Luis M/0000-0003-2153-6608; Vilarino, Natalia/0000-0001-6055-6359; Louzao, M. Carmen/0000-0002-3072-0637 FU FEDER; Ministerio de Ciencia y Tecnologia, Spain [AGL2009-13581-CO2-01, AGL2012-40485-CO2-01]; Xunta de Galicia, Spain [10PXIB261254 PR]; European Union [211326 - CP, 265896 BAMMBO, 265409 muAQUA, 262649 BEADS, 315285 Ciguatools, 312184 PharmaSea]; Atlantic Area Programme (Interreg IVB Trans-national) [2009-1/117 Pharmatlantic] FX The research leading to these results has received funding from FEDER cofunded-grants. Ministerio de Ciencia y Tecnologia, Spain: AGL2009-13581-CO2-01, AGL2012-40485-CO2-01; Xunta de Galicia, Spain: 10PXIB261254 PR; European Union's Seventh Framework Programme managed by REA - Research Executive Agency (http://ec.europa.eu/research/rea) (FP7/2007-2013) under grant agreement numbers 211326 - CP (CONffIDENCE), 265896 BAMMBO, 265409 mu AQUA, and 262649 BEADS, 315285 Ciguatools and 312184 PharmaSea; Atlantic Area Programme (Interreg IVB Trans-national): 2009-1/117 Pharmatlantic. NR 74 TC 9 Z9 10 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1742-464X EI 1742-4658 J9 FEBS J JI FEBS J. PD AUG PY 2013 VL 280 IS 16 BP 3906 EP 3919 DI 10.1111/febs.12390 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 253ZM UT WOS:000327129400014 PM 23773601 ER PT J AU Panchang, V Jeong, CK Demirbilek, Z AF Panchang, Vijay Jeong, Chan Kwon Demirbilek, Zeki TI Analyses of Extreme Wave Heights in the Gulf of Mexico for Offshore Engineering Applications SO JOURNAL OF OFFSHORE MECHANICS AND ARCTIC ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID COASTAL REGIONS; HURRICANE-IVAN; WIND-WAVES; SEA-LEVEL; MODEL; HINDCAST; CLIMATE; VERIFICATION; SENSITIVITY; PARAMETERS AB The 2004-2008 hurricane season in the Gulf of Mexico (GOM) saw several exceedances of what was regarded, prior to that period, as the 100-year significant wave heights (SWHs) that are used for the design of offshore oil and gas facilities. As a result, these facilities sustained considerable damage and disrupted U. S. energy supplies. The wave climatology in the GOM is therefore studied in detail. A 51-year database of SWHs was constructed by using a combination of wind and wave models, and both individual wave heights and statistical measures were validated, to the extent possible, using buoy data. Analyses of the modeled data show that there is an increasing trend in the annual maximum SWHs in the eastern part of the GOM; the maximum trend is approximately 5.6 cm/year, which is of the same magnitude as that reported for the U. S. west coast. The western part; on the other hand, shows a decreasing trend. The maximum estimated 100-year SWHs (denoted by SWH100) are 19.1 m, 22.6 m and 26.7 m for the Gumbel, Weibull, and the GEV distributions, respectively. The estimates obtained here using the Weibull distribution are comparable to those obtained independently by API (API-American Petroleum Institute, 2007, "Interim Guidance on Hurricane Conditions in the Gulf of Mexico," API Bulletin No. 2INT-MET). However, the use of objective criteria to identify the optimal distribution suggests that the GEV estimates are to be preferred if the engineer wishes to emphasize the upper tail where extremes are likely to occur. The maximum increase in the SWH100 due to the 2004-2008 season is of the order of 0.9 m to 2.7 m (depending as the distribution). Information generated here is intended to supplement the design recommendations provided by API (American Petroleum Institute, 2007, "Interim Guidance on Hurricane Conditions in the Gulf of Mexico," API Bulletin No. 2INT-MET). C1 [Panchang, Vijay] Texas A&M Univ, Maritime Syst Engn Dept, Galveston, TX 77553 USA. [Jeong, Chan Kwon] Dockwise USA, Houston, TX 77084 USA. [Demirbilek, Zeki] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Demirbilek, Z (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM panchanv@tamug.edu; chankwon.jeong@gmail.com; zeki.demirbilek@usace.army.mil FU Texas Coastal Management Program (NOAA) FX This work is an outgrowth of coastal wave prediction work supported by the Texas Coastal Management Program (NOAA). Zeki Demirbilek is grateful for the technical support received in this activity from two research programs of the U. S. Army Corps of Engineers: Coastal Inlets Research Program (CIRP), and Dredging Operations and Environmental Research (DOER). Permission to publish this paper was granted by the Chief, Army Corps of Engineers. NR 55 TC 4 Z9 4 U1 1 U2 12 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0892-7219 EI 1528-896X J9 J OFFSHORE MECH ARCT JI J. Offshore Mech. Arct. Eng. Trans. ASME PD AUG PY 2013 VL 135 IS 3 AR 031104 DI 10.1115/1.4023205 PG 15 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA 240QV UT WOS:000326113000005 ER PT J AU Morrison, J Ross, J Houston, R Watson, D Rasmussen, T AF Morrison, J. Ross, J. Houston, R. Watson, D. Rasmussen, T. TI Resuscitative endovascular balloon occlusion of the aorta reduces mortality in a lethal model of non-compressible torso hemorrhage SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 [Morrison, J.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Houston, R.; Watson, D.; Rasmussen, T.] US Army Inst Surg Res, San Antonio, TX USA. [Ross, J.] 59th Med Wing, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 8 EP 8 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400022 ER PT J AU Morrison, J Jansen, J Midwinter, M Rasmussen, T Ross, J AF Morrison, J. Jansen, J. Midwinter, M. Rasmussen, T. Ross, J. TI Admission shock correlates with tranexamic acid survival benefit in trauma patients requiring massive transfusion SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 Royal Ctr Def Med, Birmingham, W Midlands, England. US Army Inst Surg Res, San Antonio, TX USA. 59th Med Wing, San Antonio, TX USA. RI Midwinter, Mark/P-6264-2015 OI Midwinter, Mark/0000-0003-1836-7137 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 48 EP 48 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400149 ER PT J AU Wohlgemut, JM Morrison, JJ Apodaca, A Driver, C Jansen, JO AF Wohlgemut, J. M. Morrison, J. J. Apodaca, A. Driver, C. Jansen, J. O. TI Demographic and geographical characteristics of paediatric trauma in scotland SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 [Wohlgemut, J. M.] Univ Aberdeen, Sch Med & Dent, Aberdeen AB9 1FX, Scotland. [Morrison, J. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Apodaca, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Driver, C.] Royal Aberdeen Childrens Hosp, Dept Paediat Surg, Aberdeen, Scotland. [Jansen, J. O.] Aberdeen Royal Infirm, Dept Surg, Aberdeen, Scotland. [Jansen, J. O.] Aberdeen Royal Infirm, Dept Intens Care Med, Aberdeen, Scotland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 48 EP 48 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400148 ER PT J AU Morrison, JJ Apodaca, AN Egan, G Watson, H Jansen, JO AF Morrison, J. J. Apodaca, A. N. Egan, G. Watson, H. Jansen, J. O. TI Destination healthcare facility of shocked trauma patients in scotland: analysis of transfusion and surgical capability of receiving hospitals SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 [Morrison, J. J.; Apodaca, A. N.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. [Watson, H.; Jansen, J. O.] Aberdeen Royal Infirm, Aberdeen, Scotland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 49 EP 49 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400151 ER PT J AU Smith, IM Beech, Z Lundy, JB Bowley, DM AF Smith, I. M. Beech, Z. Lundy, J. B. Bowley, D. M. TI Current management of combat-related bowel injury: faecal diversion now rarely used in a deployed military trauma system SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 [Smith, I. M.] 1205 Scottish Field Hosp V, Glasgow, Lanark, Scotland. [Beech, Z.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Lundy, J. B.; Bowley, D. M.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 113 EP 113 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400336 ER PT J AU Yeap, E Morrison, JJ Apodaca, AN Egan, G Jansen, JO AF Yeap, E. Morrison, J. J. Apodaca, A. N. Egan, G. Jansen, J. O. TI Trauma care in Scotland: Effect of rurality on ambulance travel times and destination healthcare facility SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY MAY 01-03, 2013 CL Glasgow, SCOTLAND SP Assoc Surg Great Britain & Ireland C1 [Yeap, E.; Jansen, J. O.] Aberdeen Royal Infirm, Aberdeen, Scotland. [Morrison, J. J.; Apodaca, A. N.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2013 VL 100 SU 7 BP 217 EP 217 PG 1 WC Surgery SC Surgery GA 240GP UT WOS:000326083400695 ER PT J AU Yao, CW Garvin, TP Alvarado, JL Marsh, CP Garrett, D AF Yao, Chun-Wei Garvin, Tim P. Alvarado, Jorge L. Marsh, Charles P. Garrett, David TI Fluid Dynamics of Condensed Droplets on Microscale Hybrid Surfaces SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Editorial Material C1 [Yao, Chun-Wei] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Garvin, Tim P.; Marsh, Charles P.] ERDC Construct Engn Res Lab, Champaign, IL USA. [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX USA. [Garrett, David] Univ N Texas, Ctr Adv Res & Technol, Denton, TX 76203 USA. RP Yao, CW (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RI Yao, Chun-Wei/K-4271-2016 OI Yao, Chun-Wei/0000-0002-9032-9592 NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 EI 1528-8943 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD AUG PY 2013 VL 135 IS 8 AR 080905 PG 1 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 241LH UT WOS:000326167900005 ER PT J AU Li, J Mourelatos, ZP Kokkolaras, M Papalambros, PY Gorsich, DJ AF Li, Jing Mourelatos, Zissimos P. Kokkolaras, Michael Papalambros, Panos Y. Gorsich, David J. TI Maximizing Design Confidence in Sequential Simulation-Based Optimization SO JOURNAL OF MECHANICAL DESIGN LA English DT Article ID MODEL VALIDATION; COMPUTATIONAL MODELS; COMPUTER-MODELS; UNCERTAINTY; FRAMEWORK AB Computational simulation models support a rapid design process. Given model approximation and operating conditions uncertainty, designers must have confidence that the designs obtained using simulations will perform as expected. The traditional approach to address this need consists of model validation efforts conducted predominantly prior to the optimization process. We argue that model validation is too daunting of a task to be conducted with meaningful success for design optimization problems associated with high-dimensional space and parameter spaces. In contrast, we propose a methodology for maximizing confidence in designs generated during the simulation-based optimization process. Specifically, we adopt a trust-region-like sequential optimization process and utilize a Bayesian hypothesis testing technique to quantify model confidence, which we maximize by calibrating the simulation model within local domains if and when necessary. This ensures that the design iterates generated during the sequential optimization process are associated with maximized confidence in the utilized simulation model. The proposed methodology is illustrated using a cantilever beam design subject to vibration. C1 [Li, Jing; Mourelatos, Zissimos P.] Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. [Kokkolaras, Michael] McGill Univ, Dept Mech Engn, Montreal, PQ H3A 0C3, Canada. [Papalambros, Panos Y.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Gorsich, David J.] US Army, TARDEC, Warren, MI 48397 USA. RP Mourelatos, ZP (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. EM li2@oakland.edu; mourelat@oakland.edu; michael.kokkolaras@mcgill.ca; pyp@umich.edu; david.j.gorsich.civ@mail.mil FU Automotive Research Center (ARC), U.S. Army Center of Excellence in Modeling and Simulation of Ground Vehicles at the University of Michigan FX Funding was provided by the Automotive Research Center (ARC), a U.S. Army Center of Excellence in Modeling and Simulation of Ground Vehicles at the University of Michigan. The support is gratefully acknowledged. The support does not constitute an endorsement by the funding agency of the opinions expressed in the paper. NR 29 TC 0 Z9 0 U1 1 U2 4 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD AUG PY 2013 VL 135 IS 8 AR 081004 DI 10.1115/1.4024470 PG 8 WC Engineering, Mechanical SC Engineering GA 241MW UT WOS:000326172300005 ER PT J AU Thampan, TM Govoni, MA Clark, JT AF Thampan, Tony M. Govoni, Mark A. Clark, John T. TI Fuel Cell Systems as Power Sources for Sensor Applications SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article DE fuel cells; DMFC; RMFC; sensors; batteries ID METHANOL STEAM; HYDROGEN AB The increasing use of unattended sensors by the Information, Surveillance, and Reconnaissance community requires the development of higher power and energy density sources to provide increased capabilities and operation time while minimizing size and weight. Among the emerging power sources, fuel cell (FC) systems potentially offer an improved alternative to existing solutions. The Communications and Electronics Research and Development and Engineering Center/Command, Power & Integration Directorate/Army Power Division's Power Sources branch has been evaluating fuel cells to meet tactical power military applications. Testing of methanol based FC systems indicates 50% weight savings over a secondary Li-ion rechargeable system at 200W h, and 30% weight savings over a primary Li battery at 600W h. However, significant technical barriers to fuel cell based power sources for sensor deployment exist, including requirements for additional size and weight reduction to meet portable sensor design requirements. Additionally, testing of FC systems demonstrate the importance of appropriate battery hybridization to maintain load following as well as increasing system power density. A comparison of a Reformed Methanol FC system and a Direct Methanol FC system was also completed, and results for the system size, weight, and fuel consumption are similar for both technologies. To examine the benefits of larger power fuel cells appropriate for stationary unattended sensor use, a comparison of power and weight available from a solar/battery hybrid system versus a solar/battery/RMFC hybrid system was also completed. Although the solar/battery hybrid system's size and weight are larger than the hybrid system with an FC unit, 14 kg versus 8 kg, respectively, there is significant logistic burden when utilizing a FC system due to its methanol refueling requirement. C1 [Thampan, Tony M.] US Army RDECOM CERDEC CPI, Aberdeen Proving Ground, MD 21005 USA. [Govoni, Mark A.] US Army RDECOM CERDEC I2WD, Aberdeen Proving Ground, MD 21005 USA. [Clark, John T.] US ARMYRDECOM ARL, Adelphi, MD 20783 USA. RP Thampan, TM (reprint author), US Army RDECOM CERDEC CPI, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA. EM tony.m.thampan.civ@mail.mil NR 21 TC 1 Z9 1 U1 0 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X EI 1551-6989 J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD AUG PY 2013 VL 10 IS 4 AR 044501 DI 10.1115/1.4024566 PG 5 GA 240LP UT WOS:000326098100009 ER PT J AU Howard, IL Doyle, JD Cox, BC AF Howard, Isaac L. Doyle, Jesse D. Cox, Ben C. TI Merits of reclaimed asphalt pavement-dominated warm mixed flexible pavement base layers SO ROAD MATERIALS AND PAVEMENT DESIGN LA English DT Article DE reclaimed asphalt pavement; warm mix asphalt; wheel tracking; moisture damage; durability; cracking ID LABORATORY EVALUATION; PERFORMANCE; TECHNOLOGY; MIXTURES AB Use of reclaimed asphalt pavement (RAP) has increased considerably over the past few years; approximately 85% of the RAP available is used within either hot mix asphalt (HMA) or warm mix asphalt (WMA). Within this time frame a number of research efforts have been performed, but most efforts have focused on RAP contents of 50% or less. This paper describes a laboratory effort that studied WMA with RAP contents of 50-100% in the areas of rutting, moisture damage, durability, cracking, and mixing uniformity. Lack of a RAP surplus coupled with performance data presented in this paper indicates that mixtures with more than 50% RAP do not, for most applications, add value to the highway system in present day. WMA with 50% RAP for use as an underlying (or base) pavement layer performed adequately in all performance areas investigated, durability and cracking included. C1 [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. [Doyle, Jesse D.] USA, Airfields & Pavements Branch, Geotech & Struct Lab, CEERD GM A,Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Cox, Ben C.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Howard, IL (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, POB 9546,235 Walker Hall, Mississippi State, MS 39762 USA. EM ilhoward@cee.msstate.edu NR 43 TC 5 Z9 6 U1 1 U2 11 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1468-0629 J9 ROAD MATER PAVEMENT JI Road Mater. Pavement Des. PD AUG 1 PY 2013 VL 14 SU 2 SI SI BP 106 EP 128 DI 10.1080/14680629.2013.812834 PG 23 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 221PL UT WOS:000324670700007 ER PT J AU Doyle, JD Howard, IL AF Doyle, Jesse D. Howard, Isaac L. TI Rutting and moisture damage resistance of high reclaimed asphalt pavement warm mixed asphalt: loaded wheel tracking vs. conventional methods SO ROAD MATERIALS AND PAVEMENT DESIGN LA English DT Article DE loaded wheel tracking; WMA; RAP; rutting; moisture damage; PURWheel ID MIXTURES; PERFORMANCE; TECHNOLOGY AB An increased potential for moisture damage and rutting has been the two main problems with warm mixed asphalt (WMA) implementation. The use of high reclaimed asphalt pavement (RAP) contents (25% or more) in WMA may alleviate these problems. At present, susceptibility to the moisture damage and rutting are usually tested for independently; however, these distress mechanisms can be linked for in-service pavements. An enhanced loaded wheel tracking test performed on dry and wet specimens, the PURWheel, is investigated in this paper to evaluate the interaction of traffic and moisture. The PURWheel is also compared with conventional rutting and moisture damage tests. PURWheel results are used to evaluate the performance of 25% and 50% RAP-WMA. Rutting and moisture susceptibility of the high RAP-WMA was comparable with current practice low RAP content hot mixed asphalt. C1 [Doyle, Jesse D.] USA, Airfields & Pavements Branch, Geotech & Struct Lab, CEERD GM A,Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Doyle, JD (reprint author), USA, Airfields & Pavements Branch, Geotech & Struct Lab, CEERD GM A,Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.d.doyle@erdc.dren.mil FU Mississippi DOT under State Study [212] FX This research was funded by the Mississippi DOT under State Study 212. Scott Glusenkamp of APAC Mississippi is thanked for his assistance in the location of field mixtures. Dr. Thomas D. White is thanked for his assistance in a variety of manners including securing the original PURWheel equipment, and for the technical guidance related to wheel tracking and finite element modelling. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, US Army Engineer Research and Development Center. NR 48 TC 9 Z9 11 U1 1 U2 24 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1468-0629 J9 ROAD MATER PAVEMENT JI Road Mater. Pavement Des. PD AUG 1 PY 2013 VL 14 SU 2 SI SI BP 148 EP 172 DI 10.1080/14680629.2013.812841 PG 25 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 221PL UT WOS:000324670700009 ER PT J AU Kane, SF Saperstein, AK Bunt, CW Stephens, MB AF Kane, Shawn F. Saperstein, Adam K. Bunt, Christopher W. Stephens, Mark B. TI When war follows combat veterans home SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; UNITED-STATES; ALCOHOL-USE; IRAQ; AFGHANISTAN; CARE; MILITARY; RISK C1 [Kane, Shawn F.; Saperstein, Adam K.; Bunt, Christopher W.; Stephens, Mark B.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP Kane, SF (reprint author), USASOC, 2929 Desert Storm Dr, Ft Bragg, NC 28310 USA. EM shawn.kane@us.army.mil RI Stephens, Mark/A-2679-2015; OI Bunt, Christopher/0000-0002-5130-6902 NR 56 TC 0 Z9 0 U1 0 U2 3 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD AUG PY 2013 VL 62 IS 8 BP 399 EP 407 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 218WW UT WOS:000324464300003 PM 24143332 ER PT J AU Xu, WZ Zhang, YF Cheng, GM Jian, WW Millett, PC Koch, CC Mathaudhu, SN Zhu, YT AF Xu, Weizong Zhang, Yongfeng Cheng, Guangming Jian, Weiwei Millett, Paul C. Koch, Carl C. Mathaudhu, Suveen N. Zhu, Yuntian TI In-situ atomic-scale observation of irradiation-induced void formation SO NATURE COMMUNICATIONS LA English DT Article ID VOLTAGE ELECTRON-MICROSCOPE; NEUTRON-IRRADIATION; RADIATION-DAMAGE; DISLOCATION LOOPS; GAS-BUBBLES; HCP METALS; NUCLEATION; EVOLUTION; ZIRCONIUM; ALLOYS AB The formation of voids in an irradiated material significantly degrades its physical and mechanical properties. Void nucleation and growth involve discrete atomic-scale processes that, unfortunately, are not yet well understood due to the lack of direct experimental examination. Here we report an in-situ atomic-scale observation of the nucleation and growth of voids in hexagonal close-packed magnesium under electron irradiation. The voids are found to first grow into a plate-like shape, followed by a gradual transition to a nearly equiaxial geometry. Using atomistic simulations, we show that the initial growth in length is controlled by slow nucleation kinetics of vacancy layers on basal facets and anisotropic vacancy diffusivity. The subsequent thickness growth is driven by thermodynamics to reduce surface energy. These experiments represent unprecedented resolution and characterization of void nucleation and growth under irradiation, and might help with understanding the irradiation damage of other hexagonal close-packed materials. C1 [Xu, Weizong; Cheng, Guangming; Jian, Weiwei; Koch, Carl C.; Zhu, Yuntian] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Zhang, Yongfeng] Idaho Natl Lab, Idaho Falls, ID 83415 USA. [Millett, Paul C.] Univ Arkansas, Dept Mech Engn, Fayetteville, AR 72701 USA. [Mathaudhu, Suveen N.] US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Zhu, YT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ytzhu@ncsu.edu RI Zhu, Yuntian/B-3021-2008; Cheng, Guangming/F-8999-2010; Mathaudhu, Suveen/B-4192-2009; Xu, Weizong/G-3328-2014 OI Zhu, Yuntian/0000-0002-5961-7422; Cheng, Guangming/0000-0001-5852-1341; Xu, Weizong/0000-0003-0030-8606 FU Laboratory Directed Research and Development Program Office of the Idaho National Laboratory [00042959-00032]; US Army Research Office [W911NF-12-1-0009] FX We thank Dr M.-H. Tsai for constructive discussions. We acknowledge financial support from the Laboratory Directed Research and Development Program Office of the Idaho National Laboratory (00042959-00032), and US Army Research Office (W911NF-12-1-0009). NR 53 TC 17 Z9 17 U1 8 U2 88 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD AUG PY 2013 VL 4 AR 2288 DI 10.1038/ncomms3288 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 209JN UT WOS:000323752000004 PM 23912894 ER PT J AU Torrieri, D Valenti, MC Talarico, S AF Torrieri, Don Valenti, Matthew C. Talarico, Salvatore TI An Analysis of the DS-CDMA Cellular Uplink for Arbitrary and Constrained Topologies SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE CDMA; cellular network; uplink; power control; rate control ID WIRELESS NETWORKS; SYSTEMS; POWER; PERFORMANCE; CAPACITY AB A new analysis is presented for the direct-sequence code-division multiple access (DS-CDMA) cellular uplink. For a given network topology, closed-form expressions are found for the outage probability and rate of each uplink in the presence of path-dependent Nakagami fading and shadowing. The topology may be arbitrary or modeled by a random spatial distribution with a fixed number of base stations and mobiles placed over a finite area. The analysis is more detailed and accurate than existing ones and facilitates the resolution of network design issues including the influence of the minimum base-station separation, the role of the spreading factor, and the impact of various power-control and rate-control policies. It is shown that once power control is established, the rate can be allocated according to a fixed-rate or variable-rate policy with the objective of either meeting an outage constraint or maximizing throughput. An advantage of variable-rate power control is that it allows an outage constraint to be enforced on every uplink, which is impossible when a fixed rate is used throughout the network. C1 [Torrieri, Don] US Army Res Lab, Adelphi, MD USA. [Valenti, Matthew C.] W Virginia Univ, Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA. [Talarico, Salvatore] W Virginia Univ, Lane Dept Commun Sci & Elect Engn, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), US Army Res Lab, Adelphi, MD USA. EM don.j.torrieri.civ@mail.mil; valenti@ieee.org; Salvatore.Talarico81@gmail.com OI Valenti, Matthew/0000-0001-6089-0509 FU National Science Foundation [CNS-0750821]; United States Army Research Laboratory [W911NF-10-0109] FX M. C. Valenti's work was sponsored by the National Science Foundation under Award No. CNS-0750821 and by the United States Army Research Laboratory under Contract W911NF-10-0109. NR 16 TC 5 Z9 5 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD AUG PY 2013 VL 61 IS 8 BP 3318 EP 3326 DI 10.1109/TCOMM.2013.070213.120911 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 208AP UT WOS:000323647500022 ER PT J AU Rudin, S Rupper, G AF Rudin, Sergey Rupper, Greg TI Plasma Instability and Wave Propagation in Gate-Controlled GaN Conduction Channels SO JAPANESE JOURNAL OF APPLIED PHYSICS LA English DT Article ID FIELD-EFFECT TRANSISTOR; 2-DIMENSIONAL ELECTRON FLUID; TERAHERTZ RADIATION; TRANSPORT AB The plasma wave in the conduction channel of a semiconductor heterostructure high electron mobility transistor (HEMT) can be excited at frequencies significantly higher than the cut-off frequency in a short channel device. The hydrodynamic model predicts a resonance response to applied harmonic signal at the plasma oscillation frequency. When either the ac voltage induced in the channel by the signal at the gate or the current applied at the drain or source contact are not very small, the plasma waves in the semiconductor channel will propagate as a shock wave. The device can be used either as a detector or a tunable source of terahertz range radiation. Using the parameters appropriate for the GaN channel we show that in both configurations the charge flow develops shock waves due to hydrodynamic nonlinearities. In a sufficiently wide channel the wave propagation separates into two or more different bands giving a two-dimensional structure to the waves. (C) 2013 The Japan Society of Applied Physics C1 [Rudin, Sergey; Rupper, Greg] US Army Res Lab, Adelphi, MD 20783 USA. RP Rudin, S (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM sergey.i.rudin.civ@mail.mil NR 22 TC 2 Z9 2 U1 2 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0021-4922 J9 JPN J APPL PHYS JI Jpn. J. Appl. Phys. PD AUG PY 2013 VL 52 IS 8 SI SI AR 08JN25 DI 10.7567/JJAP.52.08JN25 PN 2 PG 5 WC Physics, Applied SC Physics GA 211CZ UT WOS:000323883100186 ER PT J AU Wunderer, T Northrup, JE Yang, ZH Teepe, M Johnson, NM Rotella, P Wraback, M AF Wunderer, Thomas Northrup, John E. Yang, Zhihong Teepe, Mark Johnson, Noble M. Rotella, Paul Wraback, Michael TI In-Well Pumped Blue GaN-Based Vertical-External-Cavity Surface-Emitting Lasers SO JAPANESE JOURNAL OF APPLIED PHYSICS LA English DT Article ID CIRCULAR TEM00 BEAMS; SEMICONDUCTOR-LASERS; HIGH-POWER AB We describe the properties of in-well pumped blue InGaN/GaN vertical-external-cavity surface-emitting lasers. The laser hetero-structures were deposited on bulk GaN substrates by using metal-organic vapor phase epitaxy near atmospheric pressure. The active zones are comprised of up to 20 InGaN quantum wells distributed in a resonant periodic gain configuration. High-reflectivity dielectric distributed Bragg-reflectors were used as mirrors. Lasing was achieved at a wavelength of about 440-445nm by exclusively exciting the quantum wells with the 384nm emission line of a dye/N-2 laser. The laser threshold was about 240 kW/cm(2). The small pump spot diameter of about 20 mu m and the usage of dielectric mirrors result in a rather high thermal resistance, which was experimentally determined by using an all optical measurement technique based on the temperature-dependent change of the refractive index of the device. (C) 2013 The Japan Society of Applied Physics C1 [Wunderer, Thomas; Northrup, John E.; Yang, Zhihong; Teepe, Mark; Johnson, Noble M.] Palo Alto Res Ctr Inc, Palo Alto, CA 94304 USA. [Rotella, Paul; Wraback, Michael] US Army Res Lab, Adelphi, MD 20783 USA. RP Wunderer, T (reprint author), Palo Alto Res Ctr Inc, 3333 Coyote Hill Rd, Palo Alto, CA 94304 USA. EM thomas.wunderer@parc.com FU U.S. Defense Threat Reduction Agency (DTRA) under U.S. Army [W911NF-10-2-0008] FX The authors are pleased to acknowledge helpful discussions with M. Kneissl, Technische Universitat Berlin, Germany. The work was supported by the U.S. Defense Threat Reduction Agency (DTRA) under U.S. Army Contract No. W911NF-10-2-0008. NR 16 TC 1 Z9 1 U1 1 U2 22 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0021-4922 J9 JPN J APPL PHYS JI Jpn. J. Appl. Phys. PD AUG PY 2013 VL 52 IS 8 SI SI AR UNSP 08JG11 DI 10.7567/JJAP.52.08JG11 PN 2 PG 4 WC Physics, Applied SC Physics GA 211CZ UT WOS:000323883100101 ER PT J AU Chapin, MM Rochette, LM Annest, JL Haileyesus, T Conner, KA Smith, GA AF Chapin, Meyli M. Rochette, Lynne M. Annest, Joseph L. Haileyesus, Tadesse Conner, Kristen A. Smith, Gary A. TI Nonfatal Choking on Food Among Children 14 Years or Younger in the United States, 2001-2009 SO PEDIATRICS LA English DT Article DE aspiration; choking; emergency department; epidemiology; injury prevention; National Electronic Injury Surveillance System-All Injury Program ID AGED 0-14 YEARS; FOREIGN-BODIES; BODY; PREVENTION; AIRWAY AB OBJECTIVE: The objective of this study was to investigate the epidemiology of nonfatal choking on food among US children. METHODS: Using a nationally representative sample, nonfatal pediatric choking-related emergency department (ED) visits involving food for 2001 through 2009 were analyzed by using data from the National Electronic Injury Surveillance System-All Injury Program. Narratives abstracted from the medical record were reviewed to identify choking cases and the types of food involved. RESULTS: An estimated 111 914 (95% confidence interval: 83 975-139 854) children ages 0 to 14 years were treated in US hospital EDs from 2001 through 2009 for nonfatal food-related choking, yielding an average of 12 435 children annually and a rate of 20.4 (95% confidence interval: 15.4-25.3) visits per 100 000 population. The mean age of children treated for nonfatal food-related choking was 4.5 years. Children aged <= 1 year accounted for 37.8% of cases, and male children accounted for more than one-half (55.4%) of cases. Of all food types, hard candy was most frequently (15.5% [16 168 cases]) associated with choking, followed by other candy (12.8% [13 324]), meat (12.2% [12 671]), and bone (12.0% [12 496]). Most patients (87.3% [97 509]) were treated and released, but 10.0% (11 218) were hospitalized, and 2.6% (2911) left against medical advice. CONCLUSIONS: This is the first nationally representative study to focus solely on nonfatal pediatric food-related choking treated in US EDs over a multiyear period. Improved surveillance, food labeling and redesign, and public education are strategies that can help reduce pediatric choking on food. C1 [Chapin, Meyli M.; Rochette, Lynne M.; Conner, Kristen A.; Smith, Gary A.] Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA. [Rochette, Lynne M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [Annest, Joseph L.; Haileyesus, Tadesse] Ctr Dis Control & Prevent, Div Anal Res & Practice Integrat, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA. [Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA. RP Smith, GA (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, 700 Childrens Dr, Columbus, OH 43205 USA. EM gary.smith@nationwidechildrens.org FU Centers for Disease Control and Prevention [1R49CE001172] FX Ms Chapin received support for this research from a scholarship stipend provided by the Centers for Disease Control and Prevention (grant 1R49CE001172). NR 17 TC 5 Z9 5 U1 0 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD AUG PY 2013 VL 132 IS 2 BP 275 EP 281 DI 10.1542/peds.2013-0260 PG 7 WC Pediatrics SC Pediatrics GA 198XN UT WOS:000322957300050 PM 23897916 ER PT J AU Fansiri, T Fontaine, A Diancourt, L Caro, V Thaisomboonsuk, B Richardson, JH Jarman, RG Ponlawat, A Lambrechts, L AF Fansiri, Thanyalak Fontaine, Albin Diancourt, Laure Caro, Valerie Thaisomboonsuk, Butsaya Richardson, Jason H. Jarman, Richard G. Ponlawat, Alongkot Lambrechts, Louis TI Genetic Mapping of Specific Interactions between Aedes aegypti Mosquitoes and Dengue Viruses SO PLOS GENETICS LA English DT Article ID QUANTITATIVE TRAIT LOCI; YELLOW-FEVER MOSQUITO; EVOLUTIONARY GENETICS; VECTOR COMPETENCE; GUT MICROBIOTA; HOST; SUSCEPTIBILITY; EPISTASIS; INFECTION; TRANSMISSION AB Specific interactions between host genotypes and pathogen genotypes (GxG interactions) are commonly observed in invertebrate systems. Such specificity challenges our current understanding of invertebrate defenses against pathogens because it contrasts the limited discriminatory power of known invertebrate immune responses. Lack of a mechanistic explanation, however, has questioned the nature of host factors underlying GxG interactions. In this study, we aimed to determine whether GxG interactions observed between dengue viruses and their Aedes aegypti vectors in nature can be mapped to discrete loci in the mosquito genome and to document their genetic architecture. We developed an innovative genetic mapping strategy to survey GxG interactions using outbred mosquito families that were experimentally exposed to genetically distinct isolates of two dengue virus serotypes derived from human patients. Genetic loci associated with vector competence indices were detected in multiple regions of the mosquito genome. Importantly, correlation between genotype and phenotype was virus isolate-specific at several of these loci, indicating GxG interactions. The relatively high percentage of phenotypic variation explained by the markers associated with GxG interactions (ranging from 7.8% to 16.5%) is consistent with large-effect host genetic factors. Our data demonstrate that GxG interactions between dengue viruses and mosquito vectors can be assigned to physical regions of the mosquito genome, some of which have a large effect on the phenotype. This finding establishes the existence of tangible host genetic factors underlying specific interactions between invertebrates and their pathogens in a natural system. Fine mapping of the uncovered genetic loci will elucidate the molecular mechanisms of mosquito-virus specificity. C1 [Fansiri, Thanyalak; Fontaine, Albin; Lambrechts, Louis] Inst Pasteur, CNRS, Unite Rech Associee 3012, Paris, France. [Fansiri, Thanyalak; Richardson, Jason H.; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Diancourt, Laure; Caro, Valerie] Inst Pasteur, Paris, France. [Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Fansiri, T (reprint author), Inst Pasteur, CNRS, Unite Rech Associee 3012, Paris, France. EM louis.lambrechts@pasteur.fr RI Lambrechts, Louis/A-2057-2010 OI Lambrechts, Louis/0000-0001-5958-2138 FU French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; French Institut de Recherche Biomedicale des Armees FX This work was primarily funded by grant ANR-09-RPDOC-007-01 to LL from the French Agence Nationale de la Recherche. AF was supported by a postdoctoral fellowship from the French Institut de Recherche Biomedicale des Armees. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 30 Z9 30 U1 1 U2 40 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7404 J9 PLOS GENET JI PLoS Genet. PD AUG PY 2013 VL 9 IS 8 AR e1003621 DI 10.1371/journal.pgen.1003621 PG 15 WC Genetics & Heredity SC Genetics & Heredity GA 210KB UT WOS:000323830300006 PM 23935524 ER PT J AU Austin, KG Carvey, CE Farina, EK Lieberman, HR AF Austin, Krista G. Carvey, Christina E. Farina, Emily K. Lieberman, Harris R. TI Predictors of the Relationships Between Nutritional Supplement Use and Weight-Modification Goals of U.S. Army Soldiers SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE dietary supplement; health behavior; weight management ID EATING DISORDER BEHAVIORS; DIETARY-SUPPLEMENTS; BODY-IMAGE; CONTRIBUTING FACTORS; MEAL-REPLACEMENT; UNITED-STATES; WOMEN; PREVALENCE; MEN; PERFORMANCE AB Background: U.S. Army Soldiers must meet body weight and composition standards and consequently may use nutritional supplements (NS) purported to assist in weight modification (WM). Nutritional supplements are dietary supplements (DS) and foods intended to supplement the diet. Purpose: This study assessed relationships between NS use, demographic characteristics, health-related behaviors, and WM goals among U.S. Army personnel. Methods: Participants (N = 990) self-reported NS use, categorized as energy drinks, sport nutrition products, or DS, and WM goal (lose, gain, or maintain) was ascertained by survey. DS were sub-categorized as health, weight-loss, weight-gain, or other DS. Chi-square and logistic regression were used to assess relationships between predictors, NS use, and WM goal. Most respondents (70.3% +/- 1.7%) consumed some NS; however, overall NS use was not related to WM goal. Significant relationships were observed between predictors (tobacco use, age, body-mass index, fitness score, general health, and eating habits) and both WM goal and NS use. Respondents attempting to lose or maintain weight were less likely to consume energy drinks and weight-gain DS. Conclusion: WM goal is related to multiple health behaviors including tobacco use, physical fitness score, and self-perception of health and eating behavior. NS are consumed in this population regardless of WM goal. C1 [Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Carvey, Christina E.; Lieberman, Harris R.] US Army Res Inst Environm Med, Natick, MA USA. RP Austin, KG (reprint author), Oak Ridge Inst Sci & Educ, Belcamp, MD USA. FU U.S. Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplement Research. The opinions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Approved for public release; distribution is unlimited. NR 37 TC 3 Z9 3 U1 2 U2 26 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD AUG PY 2013 VL 23 IS 4 BP 322 EP 335 PG 14 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 208BE UT WOS:000323649500003 PM 23239674 ER PT J AU Srinivasan, P Yasgar, A Luci, DK Beatty, WL Hu, X Andersen, J Narum, DL Moch, JK Sun, HM Haynes, JD Maloney, DJ Jadhav, A Simeonov, A Miller, LH AF Srinivasan, Prakash Yasgar, Adam Luci, Diane K. Beatty, Wandy L. Hu, Xin Andersen, John Narum, David L. Moch, J. Kathleen Sun, Hongmao Haynes, J. David Maloney, David J. Jadhav, Ajit Simeonov, Anton Miller, Louis H. TI Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion SO NATURE COMMUNICATIONS LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM; PROTEIN-INTERACTION; HOT-SPOTS; AMA1; RESISTANCE; INHIBITORS; BINDING; POTENT; P53 AB Plasmodium falciparum resistance to artemisinin derivatives, the first-line antimalarial drug, drives the search for new classes of chemotherapeutic agents. Current discovery is primarily directed against the intracellular forms of the parasite. However, late schizont-infected red blood cells (RBCs) may still rupture and cause disease by sequestration; consequently targeting invasion may reduce disease severity. Merozoite invasion of RBCs requires interaction between two parasite proteins AMA1 and RON2. Here we identify the first inhibitor of this interaction that also blocks merozoite invasion in genetically distinct parasites by screening a library of over 21,000 compounds. We demonstrate that this inhibition is mediated by the small molecule binding to AMA1 and blocking the formation of AMA1-RON complex. Electron microscopy confirms that the inhibitor prevents junction formation, a critical step in invasion that results from AMA1-RON2 binding. This study uncovers a strategy that will allow for highly effective combination therapies alongside existing antimalarial drugs. C1 [Srinivasan, Prakash; Andersen, John; Miller, Louis H.] NIAID, Lab Malaria & Vector Res, Div Intramural Res, NIH, Bethesda, MD 20852 USA. [Yasgar, Adam; Luci, Diane K.; Hu, Xin; Sun, Hongmao; Maloney, David J.; Jadhav, Ajit; Simeonov, Anton] NIH, Natl Ctr Advancing Translat Sci, Bethesda, MD 20850 USA. [Beatty, Wandy L.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63130 USA. [Narum, David L.] NIAID, Lab Malaria Immunol & Vaccinol, Div Intramural Res, NIH, Bethesda, MD 20852 USA. [Moch, J. Kathleen; Haynes, J. David] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Srinivasan, P (reprint author), NIAID, Lab Malaria & Vector Res, Div Intramural Res, NIH, Bethesda, MD 20852 USA. EM srinivasanp@niaid.nih.gov FU Division of Intramural Research, NIAID, NIH; Molecular Libraries Program, NIH Common Fund FX This study was supported in part by the Division of Intramural Research, NIAID, NIH and by the Molecular Libraries Program, NIH Common Fund. We thank Dr. Jason Regules for providing the FVO parasite, Dr. Susan Pierce for critical reading and suggestions on the manuscript. We thank Wendy Lea, Sam Michael, Paul Shinn, Danielle van Leer and Michael Balcom for their help with the binding assays, online robotic screen and compound management. NR 40 TC 35 Z9 35 U1 0 U2 20 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD AUG PY 2013 VL 4 AR 2261 DI 10.1038/ncomms3261 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 209JG UT WOS:000323751200001 PM 23907321 ER PT J AU Kragh, JF Johnson, JE Henkel, CK Dubick, MA AF Kragh, John F., Jr. Johnson, James E. Henkel, Craig K. Dubick, Michael A. TI Technique of axillary use of a Combat Ready Clamp to stop junctional bleeding SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter C1 [Kragh, John F., Jr.] US Army, Inst Surg Res, Ft Sam Houston, TX USA. [Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Johnson, James E.] Wake Forest Univ, Ctr Appl Learning, Wake Forest Sch Med, Winston Salem, NC 27109 USA. [Henkel, Craig K.] Wake Forest Hlth Sci Sch Med, Dept Neurobiol & Anat, Ctr Appl Learning, Anat Resource Clin Training Ctr, Winston Salem, NC USA. [Dubick, Michael A.] US Army, Inst Surg Res, Houston, TX USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX USA. EM john.kragh1@us.army.mil; jejohn@wfubmc.edu; chenkel@wakehealth.edu; Michael.dubick@us.army.mil NR 6 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD AUG PY 2013 VL 31 IS 8 BP 1274 EP 1276 DI 10.1016/j.ajem.2013.02.027 PG 3 WC Emergency Medicine SC Emergency Medicine GA 201SN UT WOS:000323163400024 PM 23809094 ER PT J AU Stetz, MC Folen, RA Van Horn, S Ruseborn, D Samuel, KM AF Stetz, Melba C. Folen, Raymond A. Van Horn, Sandra Ruseborn, Daniel Samuel, Kevin M. TI Technology Complementing Military Psychology Programs and Services in the Pacific Regional Medical Command SO PSYCHOLOGICAL SERVICES LA English DT Article DE behavioral health; military; virtual reality; telepsychology; biofeedback ID VIRTUAL-REALITY; MENTAL-HEALTH; THERAPY AB The Tripler Army Medical Center is the only federal tertiary care hospital serving the Pacific Regional Medical Command. Due to Tripler's large area of responsibility, many behavioral health professionals are starting to employ more technology during their sessions. As explained in this article, virtual reality and telepsychology efforts are proving to benefit military service members and their families in the Pacific Rim. C1 [Stetz, Melba C.; Folen, Raymond A.; Van Horn, Sandra; Ruseborn, Daniel; Samuel, Kevin M.] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. RP Stetz, MC (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM melba.stetz@us.army.mil NR 24 TC 0 Z9 0 U1 0 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 J9 PSYCHOL SERV JI Psychol. Serv. PD AUG PY 2013 VL 10 IS 3 SI SI BP 283 EP 288 DI 10.1037/a0027896 PG 6 WC Psychology, Clinical SC Psychology GA 198HX UT WOS:000322914400003 PM 22984878 ER PT J AU Knox, JB Wimberly, RL Riccio, AI AF Knox, Jeffrey B. Wimberly, Robert L. Riccio, Anthony I. TI Pediatric lateral distraction injury of the lumbar spine: a case report SO SPINE JOURNAL LA English DT Article DE Lateral distraction; Pediatric; Chance; Seatbelt syndrome; Lap belt AB BACKGROUND CONTEXT: Lateral distraction injuries represent a very rare pattern of injury with only five cases reported in the literature. Such injuries are a result of high-energy trauma and have a high association with severe concomitant injuries. All previous reports of this injury are in skeletally mature individuals, and this has not been previously described in young children. PURPOSE: To report a case of a lateral distraction injury in a young child secondary to improper seat belt use. STUDY DESIGN: Case report and review of the literature. PATIENT SAMPLE: Case report of an 8-year-old girl involved in a highway speed head-on collision. METHODS: We report here on an 8-year-old girl who was lying supine in the backseat of a motor vehicle while wearing a lap belt when the vehicle was involved in a high-speed motor vehicle crash. She presented with focal back pain, abdominal pain, and a seat belt sign. Imaging demonstrated focal coronal plane deformity with unilateral ligamentous disruption. The patient was diagnosed with a ligamentous lateral distraction injury of the lumbar spine. This injury was treated with open reduction and posterior spinal fusion with pedicle screw fixation. RESULTS: The patient tolerated the procedure well and had an uneventful postoperative course. CONCLUSIONS: In this case, we describe a lateral distraction injury in a young child secondary to improper seat belt use. This represents the first description of such an injury in this age group, and this case highlights the spectrum of injury caused by improper seat belt use in the pediatric population. Published by Elsevier Inc. C1 [Knox, Jeffrey B.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75235 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA. RP Knox, JB (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.bruce.knox@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD AUG PY 2013 VL 13 IS 8 BP E45 EP E48 DI 10.1016/j.spinee.2013.05.015 PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 201VH UT WOS:000323170600009 PM 23773432 ER PT J AU Casey, SD Sadler, BM AF Casey, Stephen D. Sadler, Brian M. TI Pi, the Primes, Periodicities, and Probability SO AMERICAN MATHEMATICAL MONTHLY LA English DT Article ID EUCLIDEAN ALGORITHM AB The theory of numbers has repeatedly shown itself to be both practical and beautiful. This paper gives an example of this duality. We present a very efficient (and practical) algorithm for extracting the fundamental period from a set of sparse and noisy observations of a periodic process. The procedure is computationally straightforward, stable with respect to noise, and converges quickly. Its use is justified by a theorem, which shows that for a set of randomly chosen positive integers, the probability that they do not all share a common prime factor approaches one quickly as the cardinality of the set increases. The proof of this theorem rests on a (beautiful) probabilistic interpretation of the Riemann zeta function. C1 [Casey, Stephen D.] American Univ, Dept Math & Stat, Washington, DC 20016 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Casey, SD (reprint author), American Univ, Dept Math & Stat, 4400 Massachusetts Ave NW, Washington, DC 20016 USA. EM scasey@american.edu; brian.m.sadler6.civ@mail.mil FU U.S. Army Research Office Scientific Services program [TCN 09-235, W911NF-07-D-0001]; U.S. Air Force Office of Scientific Research [FA9550-12-1-0430] FX The authors would like to express their sincere thanks to Professor Lawrence Washington of the University of Maryland, Professor David Joyner of the U.S. Naval Academy and Professors Jeffrey Adler, Michael Black, Lawrence Crone, Ali Enayat, Mary Gray, Richard Holzsager, Dan Kalman, and Joshua Lansky of American University for many insightful discussions. They would also like to give their sincere thanks to the referees for their valuable input. The first author's research was partially supported by U.S. Army Research Office Scientific Services program, administered by Battelle (TCN 09-235 Contract Number W911NF-07-D-0001) and U.S. Air Force Office of Scientific Research Grant Number FA9550-12-1-0430. NR 32 TC 2 Z9 2 U1 0 U2 1 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 USA SN 0002-9890 J9 AM MATH MON JI Am. Math. Mon. PD AUG-SEP PY 2013 VL 120 IS 7 BP 594 EP 608 DI 10.4169/amer.math.monthly.120.07.594 PG 15 WC Mathematics SC Mathematics GA 191MS UT WOS:000322417800002 ER PT J AU Korva, M Saksida, A Kejzar, N Schmaljohn, C Avsic-Zupanc, T AF Korva, M. Saksida, A. Kejzar, N. Schmaljohn, C. Avsic-Zupanc, T. TI Viral load and immune response dynamics in patients with haemorrhagic fever with renal syndrome SO CLINICAL MICROBIOLOGY AND INFECTION LA English DT Meeting Abstract C1 [Korva, M.; Saksida, A.; Avsic-Zupanc, T.] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia. [Kejzar, N.] Univ Ljubljana, Fac Med, Inst Biostat & Med Informat, Ljubljana, Slovenia. [Schmaljohn, C.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1198-743X J9 CLIN MICROBIOL INFEC JI Clin. Microbiol. Infect. PD AUG PY 2013 VL 19 IS 8 BP 778 EP 778 DI 10.1111/1469-0691.12306 PG 1 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 182RP UT WOS:000321761900027 ER PT J AU Korva, M Saksida, A Kejzar, N Schmaljohn, C Avsic-Zupanc, T AF Korva, M. Saksida, A. Kejzar, N. Schmaljohn, C. Avsic-Zupanc, T. TI Viral load and immune response dynamics in patients with haemorrhagic fever with renal syndrome SO CLINICAL MICROBIOLOGY AND INFECTION LA English DT Article DE Cytokines; dynamic; hantavirus; humoral response; serial samples ID PUUMALA-HANTAVIRUS INFECTION; NEPHROPATHIA-EPIDEMICA; GENETIC SUSCEPTIBILITY; PULMONARY SYNDROME; RNA LOAD; DISEASE; VIRUS; PATHOGENESIS; POLYMORPHISM; SEVERITY AB Haemorrhagic fever with renal syndrome (HFRS) in Slovenia can be caused by infection with either Dobrava (DOBV) or Puumala (PUUV) virus, but a clear difference in disease severity is observed. We hypothesized that the wide spectrum of disease observed among HFRS patients might be related to differing immune responses and viral load kinetics. To test this hypothesis we analysed sequential blood samples from 29 HFRS patients hospitalized in Slovenia. Measuring viral RNA in patient samples revealed that viraemia lasts for longer than previously believed, with DOBV or PUUV-infected patients having viraemias lasting on average 30days or 16days, respectively. DOBV-infected patients were found to have a higher viral load than the PUUV-infected patients (10(7) vs. 10(5) RNA copies/mL). Both DOBV and PUUV-infected patients had IgM at the time of hospital admission, but there was a difference in IgG antibody dynamics, with only a minority of DOBV-infected patients having IgG antibodies. In our study, elevated levels of IL-10, TNF- and IFN- were detected in all of the samples regardless of the causative agent. In DOBV-infected patients the decrease in cytokine secretion level appeared around day 20 post-infection, while in PUUV-infected patients the change was earlier. In general, our findings point toward notable differences between PUUV and DOBV infections, in terms of viral load and antibody and cytokine response dynamics, all of which may be reflected in differing disease severities and clinical outcomes. C1 [Korva, M.; Saksida, A.; Avsic-Zupanc, T.] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana 1000, Slovenia. [Kejzar, N.] Univ Ljubljana, Fac Med, Inst Biostat & Med Informat, Ljubljana 1000, Slovenia. [Schmaljohn, C.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Avsic-Zupanc, T (reprint author), Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Zaloska 4, Ljubljana 1000, Slovenia. EM tatjana.avsic@mf.uni-lj.si FU US Civilian Research and Development Foundation [SIB1-2964-LJ-09]; Ministry of Higher Education, Science and Sport of Slovenia [P3-0083] FX This study was supported by the US Civilian Research and Development Foundation [SIB1-2964-LJ-09] and by the Ministry of Higher Education, Science and Sport of Slovenia (grant No. P3-0083). NR 32 TC 14 Z9 14 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1198-743X J9 CLIN MICROBIOL INFEC JI Clin. Microbiol. Infect. PD AUG PY 2013 VL 19 IS 8 BP E358 EP E366 DI 10.1111/1469-0691.12218 PG 9 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 182RP UT WOS:000321761900005 PM 23573903 ER PT J AU Jones, A AF Jones, Alvin TI Test of Memory Malingering: Cutoff Scores for Psychometrically Defined Malingering Groups in a Military Sample SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article DE Test of Memory Malingering; Performance validity; Malingering; Symptom validity ID TRAUMATIC BRAIN-INJURY; SYMPTOM VALIDITY TEST; RESPONSE BIAS; CLASSIFICATION ACCURACY; NEUROPSYCHOLOGICAL ASSESSMENT; REPEATABLE BATTERY; LIKELIHOOD RATIOS; SUSPECT EFFORT; EFFORT INDEX; PERFORMANCE AB This research examined cutoffs for the Test of Memory Malingering (TOMM) in a military sample composed primarily of mTBI patients. The results are consistent with previous research and provide additional evidence that cutoffs higher than those originally recommended for the TOMM can produce excellent classification and diagnostic statistics when a psychometrically defined non-malingering group is compared with three psychometrically defined malingering groups: Probable, Probable to Definite, and Definite Malingering. The groups were formed based on the number of symptom and performance validity tests passed or failed. Cutoffs that were 4-5 points higher for Trial 2 and the Retention Trial than originally recommended produced very low false positive rates (.0 to .06) and excellent positive predictive values (.75 to 1.00) for a base rate of malingering commonly found in TBI patients. Positive likelihood ratios were all above 10 for these two trials indicating excellent ability to rule in malingering. A range of cutoffs for Trial 1 were also examined, and classification and diagnostic statistics are presented for cutoffs ranging from 40 to 44 with results similar to the other TOMM trials. C1 Womack Army Med Ctr, Dept Brain Injury Med, Ft Bragg, NC 29310 USA. RP Jones, A (reprint author), Womack Army Med Ctr, Dept Brain Injury Med, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 29310 USA. EM alvin.jones2@us.army.mil NR 51 TC 9 Z9 9 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1385-4046 EI 1744-4144 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PD AUG 1 PY 2013 VL 27 IS 6 BP 1043 EP 1059 DI 10.1080/13854046.2013.804949 PG 17 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 197RA UT WOS:000322867100010 PM 23730741 ER PT J AU Michalsen, MM Weiss, R King, A Gent, D Medina, VF Istok, JD AF Michalsen, Mandy M. Weiss, Rebecca King, Aaron Gent, David Medina, Victor F. Istok, Jonathan D. TI Push-Pull Tests for Estimating RDX and TNT Degradation Rates in Groundwater SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; CONTAMINATED SOIL; ANAEROBIC BIOTRANSFORMATION; BIODEGRADATION COLUMN; BIOLOGICAL TREATMENT; AQUIFER SLURRIES; ELECTRON-DONORS; NITROGEN-SOURCE; SINGLE-WELL; TRANSFORMATION AB In situ bioremediation is being considered to optimize an existing pump-and-treat remedy for treatment of explosives-contaminated groundwater at the Umatilla Chemical Depot. Push-pull tests were conducted using a phased approach to measure in situ hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 2,4,6-trinitrotoluene (TNT) degradation rates associated with various carbon substrates. Phase I included short-duration transport tests conducted in each well to determine dilution rates and retardation factors for RDX and TNT. Phase II included aquifer " feedings" conducted by injecting 150 gallons of treated site groundwater amended with ethanol, corn syrup, lactose or emulsified oil (concentrations 10, 25 and 27 mM, respectively; 12% by volume for emulsified oil). Wells received up to 6 substrate " feedings" over the course of 3 months followed by monitoring dissolved oxygen, nitrate, Fe(II), and sulfate to gauge in situ redox conditions as indicators of anaerobic microbial activity. Phase III included push-pull tests conducted by injecting 150 gallons of site groundwater amended with approximately 1000 mu g/L RDX, 350 mu g/L TNT, carbon substrate and a conservative tracer, followed by sampling over 8 d. Corn syrup resulted in the best RDX removal (82% on average) and the largest RDX degradation rate coefficient (1.4 +/- 1.1 d(-1)). Emulsified oil resulted in the best TNT removal (99%) and largest TNT degradation rate coefficient (5.7 x 10(-2) d(-1)). These results will be used to simulate full-scale in situ bioremediation scenarios at Umatilla and will support a go/no-go decision to initiate full-scale bioremediation remedy optimization. C1 [Michalsen, Mandy M.; Weiss, Rebecca; King, Aaron] US Army Corps Engineers, Environm Engn & Technol Sect, Seattle, WA 98134 USA. [Gent, David; Medina, Victor F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Istok, Jonathan D.] Oregon State Univ, Dept Civil Engn, Corvallis, OR 97331 USA. RP Michalsen, MM (reprint author), US Army Corps Engineers, Environm Engn & Technol Sect, Seattle, WA 98134 USA. EM mandy.m.michalsen@usace.army.mil FU U.S. Base Realignment and Closure Division, BRACD FX Funding for this project was provided by U.S. Base Realignment and Closure Division, BRACD. Special thanks go to Joe Marsh, Tom Gardner-Clayson, and Heather Whitney for their contributions to field work and chemistry support and to Richard Wilson for Project Management support. NR 48 TC 5 Z9 5 U1 3 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD AUG PY 2013 VL 33 IS 3 BP 61 EP 68 DI 10.1111/gwmr.12016 PG 8 WC Water Resources SC Water Resources GA 198DR UT WOS:000322902600005 ER PT J AU Shanholtz, ER LaSalvia, JC AF Shanholtz, Eugene R. LaSalvia, Jerry C. TI Investigation of the Indentation-Size Effect (ISE) in a Commercial SiAlON: Multifractal Scaling Analysis and Underlying Mechanisms SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID SILICON-NITRIDE; KNOOP-HARDNESS; CERAMICS; VELOCITY; FRACTURE; SOLIDS; DAMAGE; BRITTLENESS; PERFORMANCE; COMPOSITES AB The indentation-size effect (ISE) in a commercial SiAlON was investigated by conducting Knoop indentation between 0.1 and 20kg. The resulting ISE was analyzed utilizing Meyer's Law, Proportional Specimen Resistance (PSR) model, and a Multifractal Scaling Law (MFSL). Meyer's law and the PSR model fits to the hardness-load data were not excellent. Further analysis based on the PSR model and MFSL revealed three piecewise linear fits corresponding to load regimes 0.1-0.3, 0.5-2, and 5-20kg. Physical inference of MFSL fit parameters suggested that these three load regimes correspond to where indentation behavior is governed by deformation mechanisms limited to single grains, grain boundaries, and multiple grains, respectively. Independent of the ISE analysis results, comprehensive examination of indents by scanning electron microscopy revealed that changes in deformation mechanisms could also be grouped into these three load regimes. Corresponding changes in deformation mechanisms were microcleavage cracking, grain-boundary cracking, and macrocracking, respectively. These observations are consistent with the findings of both the PSR model and MFSL with respect to the physical aspects of the governing mechanisms. It is concluded that these mechanisms are responsible for the observed ISE in this commercial SiAlON. C1 [Shanholtz, Eugene R.; LaSalvia, Jerry C.] US Army Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. RP Shanholtz, ER (reprint author), US Army Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. EM grshanholtz@gmail.com FU Internship/Research Participation Program for the U.S. Army Research Laboratory FX This project was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an agreement between the U. S. Department of Energy and the USARL. NR 49 TC 3 Z9 3 U1 0 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 2013 VL 96 IS 8 BP 2607 EP 2614 DI 10.1111/jace.12450 PG 8 WC Materials Science, Ceramics SC Materials Science GA 199AE UT WOS:000322965300041 ER PT J AU Franz, MR Wolf, EJ MacDonald, HZ Marx, BP Proctor, SP Vasterling, JJ AF Franz, Molly R. Wolf, Erika J. MacDonald, Helen Z. Marx, Brian P. Proctor, Susan P. Vasterling, Jennifer J. TI Relationships Among Predeployment Risk Factors, Warzone-Threat Appraisal, and Postdeployment PTSD Symptoms SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NEUROCOGNITION DEPLOYMENT HEALTH; MENTAL-HEALTH; PROSPECTIVE COHORT; VIETNAM VETERANS; MILITARY SERVICE; FIT INDEXES; IRAQ; AFGHANISTAN; EXPERIENCES AB Previous research indicates a relationship between perceived fear for one's safety (i.e., threat appraisal) and posttraumatic stress disorder (PTSD). This prospective study examined relationships among deployment- and predeployment-related variables, threat appraisal, and postdeployment PTSD symptom severity. Prior to Iraq deployment, 774 U.S. Army soldiers completed self-report measures assessing previous life stressors, deployment history, current (predeployment) PTSD symptoms, deployment preparedness, and unit cohesion. Following deployment, participants completed self-report measures assessing combat intensity, deployment threat appraisal, and current (postdeployment) PTSD symptoms. Structural equation modeling revealed that predeployment PTSD symptom severity, prior warzone deployment, unit cohesion, and preparedness were each independently associated with deployment threat appraisal, even after taking into account combat intensity. Deployment threat appraisal was associated with postdeployment PTSD severity. Results indicated that predeployment PTSD symptom severity, history of warzone deployment, and preparednessrisk factors previously thought to influence PTSD outcomes directlywere either partially or fully mediated by threat appraisal. The model explained 15% of the variance in deployment threat appraisal and 50% of the variance in postdeployment PTSD severity. Helping service members cope with exposure to extreme stress during deployment by modifying certain prewar risk factors may facilitate reduction of PTSD symptoms following deployment. C1 [Franz, Molly R.; MacDonald, Helen Z.; Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [Wolf, Erika J.; Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02130 USA. [Wolf, Erika J.; Marx, Brian P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. [Wolf, Erika J.; MacDonald, Helen Z.; Marx, Brian P.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, 150 S Huntington Ave 116B, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov OI Wolf, Erika/0000-0003-2666-2435 NR 35 TC 9 Z9 9 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2013 VL 26 IS 4 BP 498 EP 506 DI 10.1002/jts.21827 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 198CD UT WOS:000322898400011 PM 23893499 ER PT J AU Creech, SK Benzer, JK Liebsack, BK Proctor, S Taft, CT AF Creech, Suzannah K. Benzer, Justin K. Liebsack, Brittany K. Proctor, Susan Taft, Casey T. TI Impact of Coping Style and PTSD on Family Functioning After Deployment in Operation Desert Shield/Storm Returnees SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR VETERANS; COUPLE ADJUSTMENT; SYMPTOMS; VALIDITY AB The relationship between military combat and postdeployment family functioning difficulties has been frequently investigated in the literature, as has the relationship between types of coping and posttraumatic stress disorder (PTSD). Few studies, however, have examined these variables together, and no studies of which we are aware have examined the effect of coping on family functioning after combat exposure. This study examined coping style measured immediately after return from deployment, and PTSD symptoms and family functioning 18-24 months after return from deployment in a sample of Operation Desert Shield/Storm veterans (N = 2,949). Structural equation models suggested that the relationships between distinct coping styles on family functioning were differentially mediated by postdeployment PTSD symptoms. Results are consistent with full mediation for avoidant coping ((direct) = -.09, p = .07; (indirect) = -.17, p < .001) and partial mediation for approach coping ((direct) = .16, p < .001; (indirect) = .09, p < .001). Results suggest that the strategies used to cope with a combat stress event may impact both PTSD and family functioning outcomes, and highlight the potential utility of pre- and postdeployment coping skills training. C1 [Creech, Suzannah K.; Liebsack, Brittany K.; Taft, Casey T.] VA Boston Healthcare Syst, Natl Ctr PTSD, Behav Sci Div, Boston, MA USA. [Creech, Suzannah K.] Providence VA Med Ctr, Vulnerable Vet Populat Res Grp, Providence, RI USA. [Creech, Suzannah K.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat, Providence, RI 02912 USA. [Benzer, Justin K.] VA Boston Healthcare Syst, Ctr Org Leadership & Management Res, Boston, MA USA. [Benzer, Justin K.] Boston Univ, Dept Hlth Policy & Management, Boston, MA 02215 USA. [Proctor, Susan] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Proctor, Susan] VA Boston Healthcare Syst, Res Serv, Boston, MA USA. [Proctor, Susan] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Taft, Casey T.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. RP Creech, SK (reprint author), Providence VAMC, 830 Chalkstone Ave, Providence, RI 02908 USA. EM Suzannah.Creech@va.gov OI Benzer, Justin/0000-0001-5151-2127; Creech, Suzannah/0000-0002-6582-1673 NR 22 TC 4 Z9 4 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2013 VL 26 IS 4 BP 507 EP 511 DI 10.1002/jts.21823 PG 5 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 198CD UT WOS:000322898400012 PM 23893396 ER PT J AU Sobarzo, A Ochayon, DE Lutwama, JJ Balinandi, S Guttman, O Marks, RS Kuehne, AI Dye, JM Yavelsky, V Lewis, EC Lobel, L AF Sobarzo, Ariel Ochayon, David E. Lutwama, Julius J. Balinandi, Steven Guttman, Ofer Marks, Robert S. Kuehne, Ana I. Dye, John M. Yavelsky, Victoria Lewis, Eli C. Lobel, Leslie TI Persistent Immune Responses after Ebola Virus Infection SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID GULU AB More than a decade after infection with the Gulu strain of Sudan Ebola virus, persons in Uganda were found to have persistent immune responses. To the Editor: Ebola virus is a highly virulent emerging pathogen and a causative agent of viral hemorrhagic fever.(1) Studies of the pathogenesis of Ebola virus infection in humans have indicated that recovery is largely dependent on the development of an immune response.(1)-(3) To investigate the persistence of immune response in humans, we examined levels of cytokine expression after in vitro whole-blood stimulation in persons 12 years after infection with the Gulu strain of Sudan Ebola virus (SUDV-gul). The study was conducted in accordance with the Declaration of Helsinki and was approved by the Uganda Ministry of Health, the ... C1 [Sobarzo, Ariel; Ochayon, David E.; Guttman, Ofer; Marks, Robert S.; Yavelsky, Victoria; Lewis, Eli C.; Lobel, Leslie] Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel. [Lutwama, Julius J.; Balinandi, Steven] Uganda Virus Res Inst, Entebbe, Uganda. [Kuehne, Ana I.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Sobarzo, A (reprint author), Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel. EM leslie.lobel@gmail.com NR 5 TC 22 Z9 25 U1 1 U2 29 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 1 PY 2013 VL 369 IS 5 BP 492 EP 493 DI 10.1056/NEJMc1300266 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 193GQ UT WOS:000322547400026 PM 23902512 ER PT J AU Rice, KR Colombo, ML Wingate, J Chen, YM Cullen, J McLeod, DG Brassell, SA AF Rice, Kevin R. Colombo, Monica L. Wingate, Jonathan Chen, Yongmei Cullen, Jennifer McLeod, David G. Brassell, Stephen A. TI Low risk prostate cancer in men >= 70 years old: To treat or not to treat SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article DE Prostate cancer; Prostate specific antigen; Cancer screening; Age; Low risk; Watchful waiting ID BEAM RADIATION-THERAPY; RADICAL PROSTATECTOMY; ELDERLY-MEN; OUTCOMES; PATTERNS AB Objectives: Prostate cancer (CaP) in the aging male will become an increasingly important and controversial health care issue. We evaluated the outcomes between a variety of treatments for low-risk CaP in patients 70 years of age and older. Methods and materials: A total of 3,650 men diagnosed with CaP between 1989 and 2009 were identified in the Center for Prostate Disease Research database to be 70 years of age or older at time of diagnosis. Of these patients, 770 men met the D'Amico criteria ([13]) for low-risk disease and were treated with radical prostatectomy, external beam radiation therapy, or watchful waiting. Cox proportional hazard models were used to compare clinicopathologic features across treatment groups. Kaplan-Meier analysis was used to compare biochemical recurrence-free, progression-free, and overall survival. Results: Of the 770 patient cohort, 194 (25%) chose radical prostatectomy, 252 (33%) chose external beam radiation therapy, and 324 (42%) were initially managed by watchful waiting with 110 (34%) of this subset ultimately undergoing secondary treatment. The median follow-up was 6.4 years. There were no significant differences in distributions of race/ethnicity, number of medical comorbidities, or clinical stage across the treatment groups. Patients managed on watchful waiting without secondary treatment had the poorest overall survival on Kaplan-Meier analysis (P = 0.0001). Additionally, multivariate analysis confirmed this result for watchful waiting without secondary treatment as being a statistically significant predictor of overall mortality (HR 1.938, P = 0.0084). Published by Elsevier Inc. C1 [Rice, Kevin R.; Colombo, Monica L.; Wingate, Jonathan; McLeod, David G.; Brassell, Stephen A.] Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA. [Chen, Yongmei; Cullen, Jennifer; McLeod, David G.; Brassell, Stephen A.] Ctr Prostate Dis Res, Bethesda, MD 20814 USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA. EM Stephen.Brassell@us.army.mil NR 23 TC 1 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD AUG PY 2013 VL 31 IS 6 BP 755 EP 760 DI 10.1016/j.urolonc.2011.07.004 PG 6 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 195DF UT WOS:000322681800007 PM 21872499 ER PT J AU Clayton, JD Knap, J AF Clayton, J. D. Knap, J. TI Phase-field analysis of fracture-induced twinning in single crystals SO ACTA MATERIALIA LA English DT Article DE Phase field; Twinning; Fracture; Crystals; Modeling and simulation ID CRACK-TIP; NUCLEATION; CALCITE; MODEL; MICROSTRUCTURE; PROPAGATION; SAPPHIRE; ENERGY; SLIP AB Deformation twinning at the tip of a straight crack or notch is analyzed using a phase-field method that seeks equilibrium twin morphologies via direct minimization of a free energy functional. For isotropic solids, the tendency to twin under mode I or mode II loading is found to depend weakly on Poisson's ratio and elastic nonlinearity and strongly on surface energy and twinning shear (i.e. eigenstrain). Depending on the coherent twin boundary energy, anisotropy of surface energy is important for mode I loading but less so for mode II. Model predictions for several single crystals are in agreement with experimental observations. Calcite demonstrates a preference for mode I cleavage crack extension over crack tip twinning. Magnesium shows a likelihood for tensile twinning from a pre-existing crack on the basal plane. In sapphire, a preference for rhombohedral twins over basal twins is apparent, with the latter thinner in shape than the former. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Clayton, J. D.] USA, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Knap, J.] USA, Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil; jar-oslaw.knap.civ@mail.mil RI Clayton, John/C-7760-2009 NR 37 TC 15 Z9 15 U1 2 U2 40 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD AUG PY 2013 VL 61 IS 14 BP 5341 EP 5353 DI 10.1016/j.actamat.2013.05.023 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 196CK UT WOS:000322750800019 ER PT J AU Cheuvront, SN Kenefick, RW Charkoudian, N Sawka, MN AF Cheuvront, Samuel N. Kenefick, Robert W. Charkoudian, Nisha Sawka, Michael N. TI Limitations to the use of plasma osmolality as a hydration biomarker Reply SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Letter ID DEHYDRATION ASSESSMENT; WATER C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Charkoudian, Nisha] US Army Res, Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Sawka, Michael N.] Georgia Inst Technol, Atlanta, GA 30332 USA. RP Cheuvront, SN (reprint author), US Army Res, Inst Environm Med, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 6 TC 2 Z9 2 U1 1 U2 2 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD AUG PY 2013 VL 98 IS 2 BP 505 EP 506 DI 10.3945/ajcn.113.065482 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 189SA UT WOS:000322287400035 PM 24027788 ER PT J AU Baird, JK Elyazar, I Basri, H Chand, K Richie, TL Hoffman, SL Palmieri, JR Franke-Villasante, E Fryauff, DJ Ohrt, C Punjabi, N Maguire, JD Dennis, DT Sutanto, I Andersen, E Sismadi, P AF Baird, J. Kevin Elyazar, Iqbal Basri, Hasan Chand, Krisin Richie, Thomas L. Hoffman, Stephen L. Palmieri, James R. Franke-Villasante, Eileen Fryauff, David J. Ohrt, Colin Punjabi, Narain Maguire, Jason D. Dennis, David T. Sutanto, Inge Andersen, Ellen Sismadi, Prianto TI Purnomo Projodipuro (April 11, 1934-May 10, 2013) Tribute SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Biographical-Item C1 [Baird, J. Kevin; Elyazar, Iqbal; Basri, Hasan; Chand, Krisin] Eijkman Oxford Clin Res Unit, Jakarta 10430, Indonesia. [Richie, Thomas L.; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Palmieri, James R.] Virginia Tech Univ, Blacksburg, VA USA. [Franke-Villasante, Eileen; Fryauff, David J.] Naval Med Res Ctr, Silver Spring, MD USA. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Punjabi, Narain] Int SOS, Jakarta, Indonesia. [Maguire, Jason D.] Portsmouth Naval Hosp, Portsmouth, VA USA. [Dennis, David T.] US Ctr Dis Control, Ft Collins, CO USA. [Sutanto, Inge] Univ Indonesia, Fac Med, Jakarta, Indonesia. [Sismadi, Prianto] Sismadi Hlth Sci & Res Inst, Jakarta, Indonesia. RP Baird, JK (reprint author), Eijkman Oxford Clin Res Unit, Jalan Diponegoro 69, Jakarta 10430, Indonesia. EM jkevinbaird@yahoo.com FU Wellcome Trust [089276] NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2013 VL 89 IS 2 BP 202 EP 204 DI 10.4269/ajtmh.13-0284 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 195DS UT WOS:000322683100004 PM 23926139 ER PT J AU Pan, YL Houck, JDT Clark, PA Pinnick, RG AF Pan, Yong-Le Houck, Joshua D. T. Clark, Pamela A. Pinnick, Ronald G. TI Single particle size and fluorescence spectra from emissions of burning materials in a tube furnace to simulate burn pits SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID DISSOLVED ORGANIC-CARBON; WOOD SMOKE PARTICLES; ATMOSPHERIC AEROSOL; SPECTROSCOPY; BIOMASS; SPECTROMETER; SCATTERING; EXPOSURE; CLUSTERS; ADELPHI AB A single-particle fluorescence spectrometer (SPFS) and an aerodynamic particle sizer were used to measure the fluorescence spectra and particle size distribution from the particulate emissions of 12 different burning materials in a tube furnace to simulate open-air burning of garbage. Although the particulate emissions are likely dominated by particles < 1 mu m diameter, only the spectra of supermicron particles were measured here. The overall fluorescence spectral profiles exhibit either one or two broad bands peaked around 300-450 nm within the 280-650 nm spectral range, when the particles are illuminated with a 263-nm laser. Different burning materials have different profiles, some of them (cigarette, hair, uniform, paper, and plastics) show small changes during the burning process, and while others (beef, bread, carrot, Styrofoam, and wood) show big variations, which initially exhibit a single UV peak (around 310-340 nm) and a long shoulder in visible, and then gradually evolve into a bimodal spectrum with another visible peak (around 430-450 nm) having increasing intensity during the burning process. These spectral profiles could mainly derive from polycyclic aromatic hydrocarbons with the combinations of tyrosine-like, tryptophan-like, and other humic-like substances. About 68 % of these single-particle fluorescence spectra can be grouped into 10 clustered spectral templates that are derived from the spectra of millions of atmospheric aerosol particles observed in three locations; while the others, particularly these bimodal spectra, do not fall into any of the 10 templates. Therefore, the spectra from particulate emissions of burning materials can be easily discriminated from that of common atmospheric aerosol particles. The SFFS technology could be a good tool for monitoring burning pit emissions and possibly for distinguishing them from atmospheric aerosol particles. C1 [Pan, Yong-Le; Houck, Joshua D. T.; Clark, Pamela A.; Pinnick, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU US Army Research Laboratory FX This research was supported by the US Army Research Laboratory mission funds and encouraged by the US Army Public Health Command. NR 42 TC 2 Z9 2 U1 0 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2171 EI 1432-0649 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD AUG PY 2013 VL 112 IS 1 BP 89 EP 98 DI 10.1007/s00340-013-5402-9 PG 10 WC Optics; Physics, Applied SC Optics; Physics GA 194ZP UT WOS:000322671500011 ER PT J AU Skaggs, HS Saunders, BA Miller, RW Goodrich, ST King, MS Kimbler, KD Branscum, AJ Fung, ET DePriest, PD van Nagell, JR Ueland, FR Baron, AT AF Skaggs, Hollie S. Saunders, Brook A. Miller, Rachel W. Goodrich, Scott T. King, Monica S. Kimbler, Kimberly D. Branscum, Adam J. Fung, Eric T. DePriest, Paul D. van Nagell, John R. Ueland, Frederick R. Baron, Andre T. TI Ovarian Cyst Fluids Are a Cache of Tumor Biomarkers That Include Calgranulin A and Calgranulin B Isoforms SO CANCER INVESTIGATION LA English DT Article DE Cancer Biomarkers; Detection/Diagnosis; Ovarian Cancer; Protein Profiling; Tumor Cell Biology ID ENDOTHELIAL GROWTH-FACTOR; CALCIUM-BINDING PROTEINS; SELDI-TOF-MS; DIFFERENCE GEL-ELECTROPHORESIS; NECROSIS-FACTOR-ALPHA; MASS-SPECTROMETRY; EARLY-STAGE; PROTEOMIC ANALYSIS; CANCER PATIENTS; MATRIX METALLOPROTEINASES AB SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors. C1 [Skaggs, Hollie S.] Mylan Pharmaceut Inc, Morgantown, WV USA. [Saunders, Brook A.] Knoxville Gynecol Canc Specialists, Knoxville, TN USA. [Miller, Rachel W.; DePriest, Paul D.; van Nagell, John R.; Ueland, Frederick R.; Baron, Andre T.] Univ Kentucky, Lucille P Markey Canc Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Lexington, KY 40536 USA. [Goodrich, Scott T.] US Army Med Command, Madigan Army Med Ctr, Div Gynecol Oncol, Tacoma, WA USA. [King, Monica S.] Registrat Mapi, Clin Res Org, Lexington, KY USA. [Kimbler, Kimberly D.] Univ Kentucky, Kentucky Canc Registry, Lexington, KY 40536 USA. [Branscum, Adam J.] Oregon State Univ, Coll Publ Hlth & Human Sci, Biostat Program, Corvallis, OR 97331 USA. [Fung, Eric T.] Vermillion Inc, Austin, TX USA. [Baron, Andre T.] Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, Lexington, KY 40536 USA. RP Baron, AT (reprint author), Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, 111 Washington Ave,Suite 213, Lexington, KY 40536 USA. EM abaro2@uky.edu OI Baron, Andre/0000-0001-5901-6419 FU University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; Vermillion, Inc. FX This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip (R) arrays and reagents, and access to a ProteinChip (R) Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky. NR 129 TC 2 Z9 2 U1 0 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0735-7907 EI 1532-4192 J9 CANCER INVEST JI Cancer Invest. PD AUG PY 2013 VL 31 IS 7 BP 433 EP 453 DI 10.3109/07357907.2013.802799 PG 21 WC Oncology SC Oncology GA 195XG UT WOS:000322736300001 PM 23915068 ER PT J AU Cheuvront, SN Kenefick, RW AF Cheuvront, Samuel N. Kenefick, Robert W. TI Comparison between blood and urinary indices for dehydration: a different interpretation SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Letter C1 [Cheuvront, Samuel N.; Kenefick, Robert W.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 3 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD AUG PY 2013 VL 113 IS 8 BP 2167 EP 2168 DI 10.1007/s00421-013-2661-4 PG 2 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 185HU UT WOS:000321959200026 PM 23712213 ER PT J AU Tagliente, DA AF Tagliente, Daniel A. TI The Importance of Professional Integrity SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material RP Tagliente, DA (reprint author), US Army, Diagnost & Prognost Branch, Automated Test Syst Div, Picatinny Arsenal, NJ USA. EM daniel.a.tagliente.civ@mail.mil NR 7 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD AUG PY 2013 VL 16 IS 4 BP 4 EP 5 PG 2 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 195TB UT WOS:000322725400001 ER PT J AU Tagliente, DA AF Tagliente, Daniel A. TI Low-Cost and Small Footprint Solution for Testing Low-Voltage Differential Signal Video Displays SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Article RP Tagliente, DA (reprint author), US Army, Diagnost & Prognost Branch, Automated Test Syst Div, Picatinny Arsenal, NJ USA. EM daniel.a.tagliente.civ@mail.mil NR 7 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD AUG PY 2013 VL 16 IS 4 BP 16 EP 21 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 195TB UT WOS:000322725400003 ER PT J AU Zaidi, SAR Ghogho, M McLernon, DC Swami, A AF Zaidi, Syed Ali Raza Ghogho, Mounir McLernon, Des C. Swami, Ananthram TI Achievable Spatial Throughput in Multi-Antenna Cognitive Underlay Networks with Multi-Hop Relaying SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Cognitive radio; Poisson point process; stochastic geometry; multiple-input multiple-output; ad-hoc; underlay; isolation ID AD HOC NETWORKS; MIMO MRC SYSTEMS; WIRELESS NETWORKS; PERFORMANCE ANALYSIS; TRANSMIT DIVERSITY; RADIO NETWORKS; CAPACITY; CHANNEL; INTERFERENCE; PROTOCOL AB In this article, we quantify the achievable spatial throughput of a multi-antenna Poisson cognitive radio network (CRN) collocated with a Poisson multi-antenna primary network. CR users employ Slotted-ALOHA medium access control. The success probability (SP) of a primary link is quantified in the presence of the secondary and primary interferers. It is demonstrated that two fold gains are experienced by employing multiple antennas at primary, i.e., (i) the fixed high desired SP threshold is met; (ii) CRs can also be accommodated without QoS deterioration. Further in this paper, the maximum permissible medium access probability (MAP) for CRN is derived from the link SP and primary users QoS constraint. The impact of the number of antennas and modulation employed at the primary on the permissible MAP of the CRN is also explored. Assuming that CR users employ multi-hop communication, QoS aware relaying with a radian sector forwarding area is studied. The average forward progress (AFP) and isolation probability for a CR user with QoS based connectivity is characterized under the permissible MAP. The spatial throughput for the CRN is quantified by the analysis of the AFP and the permissible MAP. It is shown that there exists an optimal MAP which maximizes the spatial throughput of the CRN. This optimal MAP is coupled with the permissible MAP, density of users, number of antennas and modulation schemes employed in both primary and secondary networks. Lastly, a few important design questions are investigated for multi-hop MIMO underlay CRNs. C1 [Zaidi, Syed Ali Raza; Ghogho, Mounir; McLernon, Des C.] Univ Leeds, Sch Elect & Elect Engn, Leeds, W Yorkshire, England. [Zaidi, Syed Ali Raza; Ghogho, Mounir] Int Univ Rabat, Rabat, Morocco. [Swami, Ananthram] US Army Res Lab, Adelphi, MD USA. RP Zaidi, SAR (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds, W Yorkshire, England. EM elsarz@leeds.ac.uk; m.ghogho@leeds.ac.uk; d.c.mclernon@leeds.ac.uk; a.swami@ieee.org NR 35 TC 7 Z9 7 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD AUG PY 2013 VL 31 IS 8 BP 1543 EP 1558 DI 10.1109/JSAC.2013.130817 PG 16 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 191EW UT WOS:000322396800017 ER PT J AU Lund, BJ Schulmeister, K AF Lund, Brian J. Schulmeister, Karl TI On the exposure limits for extended source multiple pulse laser exposures SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser safety; maximum permissible exposure (MPE); exposure limit; eye; retina; pulse ID THRESHOLDS; RADIATION AB The proposed revisions to the ANSI Z136, ICNIRP, and IEC 60825-1 laser exposure limits for multiple pulse ocular exposure for wavelengths from 400 to 1400 nm are examined for pulse durations t(p) >= t(min) (T-i). The three rules that are defined to be applied for multiple pulse exposures (or for classification for IEC 60825-1) are compared to identify criteria for which one of the rules is the critical one, i.e., the rule that limits the energy per pulse for a given exposure or product emission. Such a comparison can help to simplify a safety analysis, but also guide the design of systems for which the output is to be maximized yet still be classified as a Class 1 or Class 2 laser system. (C) 2013 Laser Institute of America. C1 [Lund, Brian J.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Schulmeister, Karl] Test House Laser LED & Lamp Safety, Seibersdorf Labs, A-2444 Seibersdorf, Austria. RP Lund, BJ (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 6 TC 1 Z9 1 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD AUG PY 2013 VL 25 IS 4 AR UNSP 042004 DI 10.2351/1.4802761 PG 11 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 193CV UT WOS:000322535900004 ER PT J AU Boutte, AM Johnson, DW Grant, S Schmid, KE Tortella, FC Dave, J AF Boutte, Angela M. Johnson, David W. Grant, Shonnette Schmid, Kara E. Tortella, Frank C. Dave, Jitendra TI TIME DEPENDANT BIOMARKER ABUNDANCE IN BRAIN TISSUE AND SERUM AFTER ACUTE PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE biomarker; GFAP; SBDP; serum; TBI C1 [Boutte, Angela M.; Johnson, David W.; Grant, Shonnette; Schmid, Kara E.; Tortella, Frank C.; Dave, Jitendra] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A64 EP A65 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800118 ER PT J AU Hosein, KK Yokobori, S Gajavelli, S Spurlock, M Rodriguez, Y Shear, DA Tortella, FC Leung, LY Bullock, MR AF Hosein, Khadil K. Yokobori, Shoji Gajavelli, Shyam Spurlock, Markus Rodriguez, Yoelvis Shear, Deborah A. Tortella, Frank C. Leung, Lai Yee Bullock, M. Ross TI ENGRAFTMENT OF FETAL CELL TRANSPLANTS IN RAT MODEL OF PENETRATING BRAIN INJURY-A "PROOF OF CONCEPT" STUDY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE fetal; multineurotrophins; penetrating ballistic brain injury (PBBI); transplant; traumatic brain injury (TBI) C1 [Hosein, Khadil K.; Yokobori, Shoji; Gajavelli, Shyam; Spurlock, Markus; Rodriguez, Yoelvis; Bullock, M. Ross] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA. [Shear, Deborah A.; Tortella, Frank C.; Leung, Lai Yee] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A90 EP A90 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800166 ER PT J AU Johnson, D Cartegena, C Boutte, A Tortella, FC Dave, J Schmid, KE AF Johnson, David Cartegena, Casandra Boutte, Angela Tortella, Frank C. Dave, Jitendra Schmid, Kara E. TI ALTERED MICRORNA EXPRESSION AT ACUTE TIME POINTS FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE microRNA; PBBI; RT PCR; TBI C1 [Tortella, Frank C.; Dave, Jitendra; Schmid, Kara E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A67 EP A67 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800123 ER PT J AU Leung, LY Wei, G Shear, DA Tortella, FC AF Leung, Lai Yee Wei, Guo Shear, Deborah A. Tortella, Frank C. TI POLYTRAUMA AND PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI): EFFECTS OF MULTIPLE SECONDARY INSULTS AND THEIR SEQUENCE ON ACUTE PHYSIOLOGY, NEUROLOGICAL DEFICITS AND MORTALITY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE hemorrhagic shock; hypoxemia; penetrating brain injury; physiology; polytrauma C1 [Leung, Lai Yee; Wei, Guo; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A95 EP A95 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800176 ER PT J AU Leung, LY Larimore, Z Holmes, L Cartagena, CM McLoughlin, S Bustos, F Schmid, KE Shear, DA Tortella, FC AF Leung, Lai Yee Larimore, Zachary Holmes, Larry Cartagena, Casandra M. McLoughlin, Shawn Bustos, Francis Schmid, Kara E. Shear, Deborah A. Tortella, Frank C. TI THE WRAIR PROJECTILE CONCUSSIVE IMPACT MODEL: EFFECTS OF IMPACT DIRECTION AND PROJECTILE PROPERTY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE concussion; gait; impact; kinematic; projectile C1 [Leung, Lai Yee; Cartagena, Casandra M.; McLoughlin, Shawn; Bustos, Francis; Schmid, Kara E.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A82 EP A83 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800152 ER PT J AU Miller, RS Brenner, L Churchill, S Bahraini, N Price, R Skiba, V Caviness, J Mooney, S Weaver, L AF Miller, R. Scott Brenner, Lisa Churchill, Susan Bahraini, Nazanin Price, Robert Skiba, Virginia Caviness, James Mooney, Scott Weaver, Lindell TI A PHASE II, RANDOMIZED, SHAM-CONTROLLED TRIAL HYPERBARIC OXYGEN FOR POST-CONCUSSION SYNDROME: IMPACT OF INTERVENTION ON SYMPTOMS AND WELL BEING SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE hyperbaric oxygen; post-concussion syndrome; sham-controlled randomized trial C1 [Miller, R. Scott] US Army Med Mat Dev Act, Ft Carson, CO USA. [Brenner, Lisa; Bahraini, Nazanin] Denver VA Med Ctr, Ft Carson, CO USA. [Churchill, Susan; Weaver, Lindell] LDS Hosp, Ft Carson, CO USA. [Price, Robert] Evans Army Community Hosp, Ft Carson, CO USA. [Mooney, Scott] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A56 EP A56 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800103 ER PT J AU Mondello, S Bramlett, HM Dixon, CE Shear, DA Schmid, KE Dietrich, WD Wang, KKW Hayes, RL Tortella, FC Kochanek, PM AF Mondello, Stefania Bramlett, Helen M. Dixon, C. Edward Shear, Deborah A. Schmid, Kara E. Dietrich, W. Dalton Wang, Kevin K. W. Hayes, Ronald L. Tortella, Frank C. Kochanek, Patrick M. TI CHARACTERIZATION OF TBI MODELS AND EVALUATION OF THE THERAPEUTIC EFFICACY OF NICOTINAMIDE, ERYTHROPOIETIN AND CYCLOSPORINE A USING BIOCHEMICAL MARKERS OF BRAIN INJURY: RESULTS FROM OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE animal model; biomarkers; neuroprotection; OBTT; traumatic brain injury C1 [Bramlett, Helen M.] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Coral Gables, FL 33124 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med Neurosurg, Pittsburgh, PA 15260 USA. [Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Coral Gables, FL 33124 USA. [Wang, Kevin K. W.] Univ Florida, Gainesville, FL 32611 USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. RI Mondello, Stefania/A-1813-2012; Kochanek, Patrick/D-2371-2015 OI Mondello, Stefania/0000-0002-8587-3614; Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A167 EP A168 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800316 ER PT J AU Oliver, TG Long, J Lewis, M VanAlbert, S Edwards, A DeMar, J Riccio, C Hill, M Leary, K Hibbeln, J Ohrt, C Gharavi, R Tong, L Driscoll, D Dalmolin, A Andrist, J Wilder, D AF Oliver, Thomas G. Long, Joseph Lewis, Michael VanAlbert, Stephen Edwards, Andrea DeMar, James Riccio, Cory Hill, Miya Leary, Kevin Hibbeln, Joseph Ohrt, Colin Gharavi, Robert Tong, Lawrence Driscoll, David Dalmolin, Angela Andrist, Joseph Wilder, Donna TI OMEGA-3 FATTY ACID EMULSION FOR THE TREATMENT OF BLAST-INDUCED TRAUMATIC BRAIN INJURY: EFFICACY OF POSTINJURY INTRAVENOUS INFUSIONS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE blast; emulsion; nutraceutical; omega-3 fatty acids; TBI C1 [Oliver, Thomas G.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A168 EP A169 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800318 ER PT J AU Shear, DA Pedersen, R Sun, J Mondello, S Wang, KKW Hayes, RL Schmid, KE Tortella, F AF Shear, Deborah A. Pedersen, Rebecca Sun, Justin Mondello, Stefania Wang, Kevin K. W. Hayes, Ronald L. Schmid, Kara E. Tortella, Frank TI OPERATION BRAIN TRAUMA THERAPY CONSORTIUM: DOSE-RESPONSE EVALUATION OF ERYTHROPOIETIN IN THE WRAIR PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE cognitive; erythropoietin; motor; OBTT; TBI C1 [Shear, Deborah A.; Pedersen, Rebecca; Sun, Justin; Schmid, Kara E.; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Gainesville, FL 32611 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A171 EP A171 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800323 ER PT J AU Shear, DA Deng-Bryant, Y Pedersen, R Sun, J Mondello, S Wang, KKW Hayes, RL Schmid, KE Tortella, FC AF Shear, Deborah A. Deng-Bryant, Ying Pedersen, Rebecca Sun, Justin Mondello, Stefania Wang, Kevin K. W. Hayes, Ronald L. Schmid, Kara E. Tortella, Frank C. TI OPERATION BRAIN TRAUMA THERAPY CONSORTIUM: DOSE-RESPONSE EVALUATION OF CYCLOSPORINE A IN THE WRAIR PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE cognitive; Cyclosporine A; motor; OBTT Consortium; TBI C1 [Shear, Deborah A.; Deng-Bryant, Ying; Pedersen, Rebecca; Sun, Justin; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Gainesville, FL 32611 USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A170 EP A171 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800322 ER PT J AU Spurlock, M Wick, A Diaz, J Yokobari, S Gajavelli, S Leung, LY Levaseur, J Tortella, FC Bullock, MR AF Spurlock, Markus Wick, Alexandra Diaz, Julio Yokobari, Shoji Gajavelli, Shyam Leung, Lai Yee Levaseur, Joseph Tortella, Frank C. Bullock, M. Ross TI FOCAL NEURODEGENERATION IN RAT FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY DESPITE ACUTE GLOBAL METABOLIC PATHOPHYSIOLOGY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 31st Annual National Neurotrauma Symposium CY AUG 04-07, 2013 CL Nashville, TN DE glucose; metabolism; neurodegeneration; pathophysiology; TBI C1 [Spurlock, Markus; Wick, Alexandra; Diaz, Julio; Yokobari, Shoji; Gajavelli, Shyam; Levaseur, Joseph; Bullock, M. Ross] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Coral Gables, FL 33124 USA. [Leung, Lai Yee; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2013 VL 30 IS 15 BP A16 EP A16 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 191WY UT WOS:000322446800026 ER PT J AU Mudhasani, R Tran, JP Retterer, C Radoshitzky, SR Kota, KP Altamura, LA Smith, JM Packard, BZ Kuhn, JH Costantino, J Garrison, AR Schmaljohn, CS Huang, IC Farzan, M Bavari, S AF Mudhasani, Rajini Tran, Julie P. Retterer, Cary Radoshitzky, Sheli R. Kota, Krishna P. Altamura, Louis A. Smith, Jeffrey M. Packard, Beverly Z. Kuhn, Jens H. Costantino, Julie Garrison, Aura R. Schmaljohn, Connie S. Huang, I-Chueh Farzan, Michael Bavari, Sina TI IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus SO JOURNAL OF VIROLOGY LA English DT Article ID WEST NILE VIRUS; DENGUE VIRUS; GENE-EXPRESSION; M-RNA; PROTEINS; CELL; ENTRY; PATHOGENESIS; INTERFERONS; PREVENTION AB We show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family, including Rift Valley fever virus (RVFV), La Crosse virus, Andes virus, and Hantaan virus, all of which can cause severe disease in humans and animals. We found that RVFV was restricted by IFITM-2 and -3 but not by IFITM-1, whereas the remaining viruses were equally restricted by all IFITMs. Indeed, at low doses of alpha interferon (IFN-alpha), IFITM-2 and -3 mediated more than half of the antiviral activity of IFN-alpha against RVFV. IFITM-2 and -3 restricted RVFV infection mostly by preventing virus membrane fusion with endosomes, while they had no effect on virion attachment to cells, endocytosis, or viral replication kinetics. We found that large fractions of IFITM-2 and IFITM-3 occupy vesicular compartments that are distinct from the vesicles coated by IFITM-1. In addition, although overexpression of all IFITMs expanded vesicular and acidified compartments within cells, there were marked phenotypic differences among the vesicular compartments occupied by IFITMs. Collectively, our data provide new insights into the possible mechanisms by which the IFITM family members restrict distinct viruses. C1 [Mudhasani, Rajini; Tran, Julie P.; Retterer, Cary; Radoshitzky, Sheli R.; Kota, Krishna P.; Altamura, Louis A.; Smith, Jeffrey M.; Costantino, Julie; Garrison, Aura R.; Schmaljohn, Connie S.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Packard, Beverly Z.] OncoImmunin Inc, Gaithersburg, MD USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Huang, I-Chueh] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA. [Farzan, Michael] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, New England Primate Res Ctr, Southborough, MA 01772 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD USA. EM sina.bavari@amedd.army.mil RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU Defense Threat Reduction Agency (DTRA); Joint Science and Technology Office for Chem Bio Defense [TMTI0048_09_RD_T]; Faculty Research Participation Program at the U.S. Army Medical Research and Materiel Command; NIAID [HHSN272200200016I] FX This study was supported by funding from the Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense (proposal TMTI0048_09_RD_T), to S.B. This research by R.M. was supported in part by an appointment to the Faculty Research Participation Program at the U.S. Army Medical Research and Materiel Command administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command. J.H.K. performed this work as an employee of Tunnell Consulting, Inc., a sub-contractor to Battelle Memorial Institute, under its prime contract with NIAID, under contract no. HHSN272200200016I. NR 51 TC 45 Z9 47 U1 1 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD AUG PY 2013 VL 87 IS 15 BP 8451 EP 8464 DI 10.1128/JVI.03382-12 PG 14 WC Virology SC Virology GA 180JO UT WOS:000321590200018 PM 23720721 ER PT J AU Fleischman, ZD Merkle, LD Newburgh, GA Dubinskii, M AF Fleischman, Zackery D. Merkle, Larry D. Newburgh, G. Alex Dubinskii, Mark TI Spectroscopic analysis of efficient laser material Ho3+:YVO4 SO OPTICAL MATERIALS EXPRESS LA English DT Article ID ABSORPTION-SPECTRA; HOLMIUM VANADATE; YVO4; CRYSTALS; ION AB The spectroscopic properties of Ho3+-doped YVO4 were studied at cryogenic temperatures in the 2 mu m spectral region to clarify recent observations of efficient dual-wavelength laser operation in this material. Energy levels of the I-5(7) and I-5(8) manifolds were determined from low-temperature absorption and fluorescence measurements. Polarized absorption cross sections were measured, and stimulated emission cross sections were determined using the reciprocity method coupled with Fuchtbauer-Ladenburg calculations. The observed laser emission wavelengths were at 2054.2 nm and 2068.5 nm. At 80 K, radiative lifetimes for the I-5(7) manifold were calculated to be 3.6 ms, and fluorescence lifetimes were measured to be 2.9 ms, indicating a quantum efficiency of similar to 80%. Analysis of the gain cross section at 80 K and 100 K showed that the laser output wavelength is very susceptible to minor changes in temperature. (C) 2013 Optical Society of America C1 [Fleischman, Zackery D.; Merkle, Larry D.; Newburgh, G. Alex; Dubinskii, Mark] US Army Res Lab, Adelphi, MD 20783 USA. RP Fleischman, ZD (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM zackery.d.fleischman.ctr@mail.mil NR 22 TC 5 Z9 5 U1 0 U2 21 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD AUG 1 PY 2013 VL 3 IS 8 BP 1176 EP 1186 DI 10.1364/OME.3.001176 PG 11 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 194JZ UT WOS:000322630100019 ER PT J AU Ren, W Zhao, Q Ramanathan, R Gao, J Swami, A Bar-Noy, A Johnson, MP Basu, P AF Ren, Wei Zhao, Qing Ramanathan, Ram Gao, Jianhang Swami, Ananthram Bar-Noy, Amotz Johnson, Matthew P. Basu, Prithwish TI Broadcasting in multi-radio multi-channel wireless networks using simplicial complexes SO WIRELESS NETWORKS LA English DT Article DE Broadcast; Multi-radio multi-channel; Ad hoc network; Simplicial complex; Minimum spanning; Minimum connected set cover ID CONNECTED DOMINATING SETS; WEIGHTED STEINER TREES; MESH NETWORKS; SPANNING TREE; ALGORITHMS AB We consider the broadcasting problem in multi-radio multi-channel ad hoc networks. The objective is to minimize the total cost of the network-wide broadcast, where the cost can be of any form that is summable over all the transmissions (e.g., the transmission and reception energy, the price for accessing a specific channel). Our technical approach is based on a simplicial complex model that allows us to capture the broadcast nature of the wireless medium and the heterogeneity across radios and channels. Specifically, we show that broadcasting in multi-radio multi-channel ad hoc networks can be formulated as a minimum spanning problem in simplicial complexes. We establish the NP-completeness of the minimum spanning problem and propose two approximation algorithms with order-optimal performance guarantee. The first approximation algorithm converts the minimum spanning problem in simplical complexes to a minimum connected set cover (MCSC) problem. The second algorithm converts it to a node-weighted Steiner tree problem under the classic graph model. These two algorithms offer tradeoffs between performance and time-complexity. In a broader context, this work appears to be the first that studies the minimum spanning problem in simplicial complexes and weighted MCSC problem. C1 [Ren, Wei] Microsoft Corp, Redmond, WA 98052 USA. [Zhao, Qing; Gao, Jianhang] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Ramanathan, Ram; Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD USA. [Bar-Noy, Amotz] CUNY, Dept Comp Sci, New York, NY 10021 USA. [Johnson, Matthew P.] Penn State Univ, Dept Comp Sci & Engn, Philadelphia, PA USA. RP Ren, W (reprint author), Microsoft Corp, Redmond, WA 98052 USA. EM wren@microsoft.com; qzhao@ucdavis.edu FU Army Research Laboratory NS-CTA [W911NF-09-2-0053] FX This work was supported by the Army Research Laboratory NS-CTA under Grant W911NF-09-2-0053. NR 23 TC 3 Z9 3 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1022-0038 J9 WIREL NETW JI Wirel. Netw. PD AUG PY 2013 VL 19 IS 6 BP 1121 EP 1133 DI 10.1007/s11276-012-0522-4 PG 13 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 185ND UT WOS:000321974700007 ER PT J AU Hinjoy, S Nelson, KE Gibbons, RV Jarman, RG Chinnawirotpisan, P Fernandez, S Tablerk, P Labrique, AB Patchanee, P AF Hinjoy, Soawapak Nelson, Kenrad E. Gibbons, Robert V. Jarman, Richard G. Chinnawirotpisan, Piyawan Fernandez, Stefan Tablerk, Penporn Labrique, Alain B. Patchanee, Prapas TI A Cross-Sectional Study of Hepatitis E Virus Infection in Pigs in Different-Sized Farms in Northern Thailand SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID SWINE HERDS; PREVALENCE; ANTIBODIES; CHINA; HEV; IDENTIFICATION; REPLICATION; SEQUENCE; STRAINS; TAIWAN AB Pigs are an important reservoir of hepatitis E virus (HEV) in many countries throughout the world. We evaluated the association between farm size and presence of serum antibodies against HEV, as well as other risk factors for infection in pigs raised in Nan Province, Thailand in a cross-sectional study. The sampling frame was a total-population census of all pig herds, stratified into three classes of the farm size according to criteria developed by the Nan provincial livestock health office. One-eighth of all pigs in each farm were sampled randomly. All pig-farm owners were interviewed to elicit information on general characteristics of their farms, biosecurity and hygienic procedures, and farm management. We obtained sera and fecal samples from 879 pigs to test for antibodies to HEV and HEV RNA. Odds ratios (OR) and 95% confidence intervals (CI) for risk factors for HEV seroprevalence were estimated by multivariate logistic regression. The overall prevalence of anti-HEV immunoglobulin G antibodies was 9.9%. Pigs studied from medium-sized farms had a higher HEV seroprevalence than those from larger farms (adjusted OR 4.95, 95% CI: 1.79, 13.70). Factors associated with HEV seropositivity included feeding pigs with agro-industrial byproducts, having veterinarians on farms, and presence of other pig farms within 100 m. Twenty-five (2.9%) of 875 sampled pig stools were positive for HEV RNA. Phylogenetic analysis revealed that all HEV isolates clustered to HEV genotype 3. C1 [Hinjoy, Soawapak] Minist Publ Hlth, Dept Dis Control, Bur Epidemiol, Nonthaburi, Thailand. [Hinjoy, Soawapak; Nelson, Kenrad E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Gibbons, Robert V.; Chinnawirotpisan, Piyawan; Fernandez, Stefan] Armed Forces Inst Med Sci, Dept Virol, Bangkok, Thailand. [Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Labrique, Alain B.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth & Epidemiol, Baltimore, MD USA. [Patchanee, Prapas] Chiang Mai Univ, Fac Vet Med, Dept Food Anim Clin, Chiang Mai 50100, Thailand. RP Patchanee, P (reprint author), Chiang Mai Univ, Fac Vet Med, Dept Food Anim Clin, Chiang Mai 50100, Thailand. EM patprapas@gmail.com FU World Health Organization's South-East Asia Regional Office FX The authors acknowledge the veterinarians and technicians from Department of Livestock Development, the pig production companies, the farmers for their cooperation, and Dr. Alden Henderson from Bureau of Epidemiology, Ministry of Public Health for his help. The support of the World Health Organization's South-East Asia Regional Office is appreciated. We also thank Punnarai Smithsuwan, Tanawat Likitkererat, Dr. Pravit Choomkasien, and Dr. Sopon Iamsirithaworn for advice during the data entry and data analysis. Finally, we thank the staff from the USAMC-AFRIMS in Bangkok for help in the diagnostic testing. NR 41 TC 6 Z9 6 U1 1 U2 16 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD AUG PY 2013 VL 10 IS 8 BP 698 EP 704 DI 10.1089/fpd.2012.1369 PG 7 WC Food Science & Technology SC Food Science & Technology GA 188TI UT WOS:000322216200005 PM 23789726 ER PT J AU Moroni, M Ngudiankama, BF Christensen, C Olsen, CH Owens, R Lombardini, ED Holt, RK Whitnall, MH AF Moroni, Maria Ngudiankama, Barbara F. Christensen, Christine Olsen, Cara H. Owens, Rossitsa Lombardini, Eric D. Holt, Rebecca K. Whitnall, Mark H. TI The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body gamma-Irradiation SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article ID NONHUMAN-PRIMATES; G-CSF; MYELOSUPPRESSION; COMBINATION; MANAGEMENT; GROWTH; CELLS; SOON AB Purpose: We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages provided by this model, the similarities to human hematologic parameters and dynamics of cell loss/recovery after irradiation provide a convenient means to compare the efficacy of drugs known to affect bone marrow cellularity and hematopoiesis. Methods and Materials: Male Gottingen minipigs, 4 to 5 months old and weighing 9 to 11 kg, were used for this study. We tested the standard off-label treatment for ARS, rhG-CSF (Neupogen, 10 mu g/kg/day for 17 days), at the estimated LD70/30 total-body gamma-irradiation (TBI) radiation dose for the hematopoietic syndrome, starting 24 hours after irradiation. Results: The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells. In addition, the administration of G-CSF resulted in maturation of monocytes/macrophages. Conclusions: These results support continuing efforts toward validation of the minipig as a large animal model for advanced testing of radiation countermeasures and characterization of the pathophysiology of ARS, and they suggest that the efficacy of G-CSF in improving survival after total body irradiation may involve mechanisms other than increasing the numbers of circulating granulocytes. (C) 2013 Elsevier Inc. C1 [Moroni, Maria; Owens, Rossitsa; Whitnall, Mark H.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Radiat Countermeasures Program, Bethesda, MD 20814 USA. [Ngudiankama, Barbara F.] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA. [Christensen, Christine] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Div Comparat Pathol, Bethesda, MD 20814 USA. [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, Biostat Consulting Ctr, Bethesda, MD 20814 USA. [Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Holt, Rebecca K.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Dept Vet Sci, Bethesda, MD 20814 USA. RP Moroni, M (reprint author), Armed Forces Radiobiol Res Inst, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM maria.moroni@usuhs.edu FU National Institute of Allergy and Infectious Diseases [Y1-AI-1759-01]; Armed Forces Radiobiology Research Institute (AFRRI) [RBB2DG] FX Supported by funding from National Institute of Allergy and Infectious Diseases Y1-AI-1759-01 and Armed Forces Radiobiology Research Institute (AFRRI) RBB2DG. The opinions or assertions contained herein are the private views of the authors and are not necessarily those of AFRRI, the Uniformed Services University of the Health Sciences, or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 20 TC 18 Z9 19 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD AUG 1 PY 2013 VL 86 IS 5 BP 986 EP 992 DI 10.1016/j.ijrobp.2013.04.041 PG 7 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 182LI UT WOS:000321743600036 PM 23845847 ER PT J AU Rodriguez, RI Ibitayo, D Quintero, PO AF Rodriguez, Rogie I. Ibitayo, Dimeji Quintero, Pedro O. TI Kinetics of Dissolution and Isothermal Solidification for Gold-Enriched Solid-Liquid Interdiffusion (SLID) Bonding SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE SLID; isothermal solidification; lead-free solder; fluxless; high temperature; eutectic gold-tin AB This paper presents the development and characterization of a fluxless die-attach soldering process based on gold-enriched solid-liquid interdiffusion (SLID). Eutectic Au-Sn and pure Au were deposited by jet vapor deposition (JVD) onto two substrates, assembled in a sandwiched structure, and processed in a vacuum furnace using different temperatures and times. Microstructural characterization, based on scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDS) analysis, revealed the formation of sound joints governed by the interdiffusion of the main constituents. Kinetic studies for the dissolution and the isothermal solidification stages were conducted. Differential scanning calorimetry (DSC) revealed a solder joint that is thermally stable up to 498A degrees C, thus demonstrating the effectiveness of using the SLID process for the production of joints which require a lower processing temperature compared with their remelting point. Based on these findings, the recommended final bonding parameters are processing temperature and time of 340A degrees C (310A degrees C < T (P) < 340A degrees C) and 5 min, respectively. C1 [Rodriguez, Rogie I.; Quintero, Pedro O.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR USA. [Ibitayo, Dimeji] US Army Res Lab, Adelphi, MD USA. RP Rodriguez, RI (reprint author), Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR USA. EM rogie.rodriguez@upr.edu; pedro.quintero@upr.edu FU US Army Research Laboratory [W911NF-11-2-0062] FX This work was supported by the US Army Research Laboratory (Collaborative Agreement W911NF-11-2-0062). Thanks are due to ARL Adelphi for their support during sample fabrication, especially to Gail Koebke for always being there during fabrication. Also, the authors want to acknowledge the following people from the US Army Corps of Engineers ERDC: Mrs. Ruth Hidalgo, Dr. Paul G. Allison, Dr. Robert Moser, and Mr. Wayne Hodo, for their support in lending facilities and equipment. NR 16 TC 2 Z9 2 U1 0 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2013 VL 42 IS 8 BP 2677 EP 2685 DI 10.1007/s11664-013-2614-z PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 186GJ UT WOS:000322029800035 ER PT J AU Sridhara, SK Yener, M Hanna, EY Rich, T Jimenez, C Kupferman, ME AF Sridhara, Shankar K. Yener, Murat Hanna, Ehab Y. Rich, Thereasa Jimenez, Camilo Kupferman, Michael E. TI Genetic Testing in Head and Neck Paraganglioma: Who, What, and Why? SO JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE LA English DT Article; Proceedings Paper CT 115th AAO-HNSF Annual Meeting and OTO EXPO CY SEP 10-14, 2011 CL San Francisco, CA SP AAO, HNSF, Hosp Univ Penn, Dept Otolaryngol DE paraganglioma; carotid body tumor; genetic testing; mutation; succinate dehydrogenase ID MUTATIONS; PREDICTORS; SDHB AB Background Genetic testing in head and neck paragangliomas (HNPG) can have profound implications in patient and family counseling. Methods Retrospective review was performed of patients with HNPG at a cancer care center from 1970 to present. Patient demographics, disease patterns, outcomes, and genetic mutations were analyzed. Results We identified 26 patients with available genetic testing results. Sixteen had mutations. Succinate dehydrogenase gene, sub unit D (SDHD) accounted for 75% of mutations, of which P81L accounted for 75%. The remainder had SDHB mutations. Patients with mutations were younger (average age 39.5 years versus 48.4 years), 63% (versus 40%) had multiple tumors, 94% (60%) had at least one carotid body tumor, and family history was positive in 38% (20%). Conclusion Patients suspected of heritable HNPG should undergo testing first at the SDHD and SDHB loci, and those with younger age, multiple tumors, carotid body tumors, and positive family history are more likely to have mutations. C1 [Sridhara, Shankar K.] Dwight Eisenhower Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Ft Gordon, GA USA. [Yener, Murat; Hanna, Ehab Y.; Kupferman, Michael E.] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA. [Rich, Thereasa] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA. [Jimenez, Camilo] Univ Texas MD Anderson Canc Ctr, Dept Endocrinol, Houston, TX 77030 USA. RP Kupferman, ME (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, 1400 Pressler St,Unit 1445, Houston, TX 77030 USA. EM mekupfer@mdanderson.org RI Hanna, Ehab/B-1593-2017 OI Hanna, Ehab/0000-0003-3241-2440 NR 15 TC 2 Z9 2 U1 0 U2 2 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 2193-6331 J9 J NEUROL SURG PART B JI Journal of Neurol. Surg. Part B PD AUG PY 2013 VL 74 IS 4 BP 236 EP 240 DI 10.1055/s-0033-1342924 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 190UM UT WOS:000322366600008 PM 24436918 ER PT J AU Barsoumian, A Sanchez, CJ Mende, K Tully, CC Beckius, ML Akers, KS Wenke, JC Murray, CK AF Barsoumian, Alice Sanchez, Carlos J. Mende, Katrin Tully, Charla C. Beckius, Miriam L. Akers, Kevin S. Wenke, Joseph C. Murray, Clinton K. TI In Vitro Toxicity and Activity of Dakin's Solution, Mafenide Acetate, and Amphotericin B on Filamentous Fungi and Human Cells SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE mold; topical therapy; trauma; war; Afghanistan ID COMBAT-RELATED INJURIES; INFECTIONS AB Objectives: Posttraumatic invasive fungal infections threaten critically injured combat-related injuries and require a combination of extensive surgery and systemic antifungal therapy, along with topical antimicrobials used adjunctively to control the infection. We evaluated the in vitro activity of topical agents in varying combinations and concentrations against molds from patients that were responsible for wound invasive fungal infections and the topical agents' toxicity to human cells.Methods: Mafenide acetate solutions (2.5%, 5%, and 7.5%), amphotericin B solutions (2 mu g/mL, 2 mg/mL, and 20 mg/mL), SMAT (5% mafenide acetate in combination with 2 mu g/mL, 2 mg/mL, and 20 mg/mL amphotericin B), and Dakin's solutions (buffered sodium hypochlorite) (0.5%, 0.25%, and 0.125% and 10-fold serial dilutions of 0.25%-0.00000025%) were evaluated for antifungal activity against 4 molds using a time-kill assay using standard conidial suspensions of 5 x 10(4) colony-forming units per milliliter. To assess cellular toxicity, confluent monolayers of human keratinocytes, dermal fibroblasts, and osteoblasts were exposed to these topical agents. Based upon efficacy and toxicity ratios, an additional 10 molds were screened with selected concentrations of the topical agents for antifungal activity and toxicity.Results: All the topical agents seemed to have a dose-dependent killing with only mafenide acetate showing time killing associated with prolonged contact. There was overall evidence of dose-dependent cytotoxicity of the various topical agents against the various cell lines tested, but there did not seem to be increased cell death with continued exposure to the agents over time. Dakin's solution exhibited dose-dependent toxicity and efficacy with 0.00025% appearing to optimize those parameters.Conclusions: Mafenide acetate and amphotericin B did not seem to persistently meet the toxicity and efficacy balance as consistently as Dakin's solution. C1 [Barsoumian, Alice; Mende, Katrin; Tully, Charla C.; Beckius, Miriam L.; Akers, Kevin S.; Murray, Clinton K.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Sanchez, Carlos J.; Akers, Kevin S.; Wenke, Joseph C.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, Ft Sam Houston, TX USA. [Mende, Katrin; Tully, Charla C.; Akers, Kevin S.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@us.army.mil FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System FX Supported by the Armed Forces Health Surveillance Center including the Global Emerging Infections Surveillance and Response System. NR 31 TC 7 Z9 7 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD AUG PY 2013 VL 27 IS 8 BP 428 EP 436 DI 10.1097/BOT.0b013e3182830bf9 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 191FO UT WOS:000322398600006 PM 23287750 ER PT J AU Crawford, KW Li, XH Xu, XQ Abraham, AG Dobs, AS Margolick, JB Palella, FJ Kingsley, LA Witt, MD Brown, TT AF Crawford, Keith W. Li, Xiuhong Xu, Xiaoqiang Abraham, Alison G. Dobs, Adrian S. Margolick, Joseph B. Palella, Frank J. Kingsley, Lawrence A. Witt, Mallory D. Brown, Todd T. TI Lipodystrophy and Inflammation Predict Later Grip Strength in HIV-Infected Men: The MACS Body Composition Substudy SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID BONE-MINERAL DENSITY; PHYSICAL PERFORMANCE; INSULIN-RESISTANCE; MUSCLE STRENGTH; SKELETAL-MUSCLE; OLDER MEN; POSTMENOPAUSAL WOMEN; ELDERLY-MEN; MASS; MORTALITY AB Body fat changes in HIV-infected persons are associated with increased systemic inflammation and increased mortality. It is unknown whether lipodystrophy is also associated with declines in physical function. Between 2001 and 2003, 33 HIV-infected men with evidence of lipodystrophy (LIPO+), 23 HIV-infected men without lipodystrophy (LIPO-), and 33 seronegative men were recruited from the Multicenter AIDS Cohort Study (MACS) for the Body Composition substudy. Visceral adipose tissue (VAT) was assessed by quantitative computed tomography. Lean body mass (LBM) and extremity fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was estimated by Homeostatic Model Assessment (HOMA). Serum interleukin (IL)-6, soluble tumor necrosis factor (TNF)-alpha receptors I and II (sTNFRI and sTNFRII), and highly sensitive C-reactive protein (hs-CRP) concentrations were quantified from archived serum samples. These measurements were correlated with grip strength measured in 2007 using linear regression. At the substudy visit, the LIPO+ group had higher HOMA, sTNFRI, sTNFRII, and IL-6 levels than the LIPO- group. In 2007, the LIPO+ group had lower median grip strength than the LIPO- group (34.4 vs. 42.7 kg, p = 0.002). Multivariable analysis of HIV+ men showed older age, lower LBM, higher sTNFRII concentrations, and LIPO+ status [adjusted mean difference -4.9 kg (p = 0.045)] at the substudy visit were independently associated with lower subsequent grip strength. Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age. C1 [Crawford, Keith W.; Li, Xiuhong; Xu, Xiaoqiang; Abraham, Alison G.; Dobs, Adrian S.; Margolick, Joseph B.; Brown, Todd T.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Crawford, Keith W.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [Palella, Frank J.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Kingsley, Lawrence A.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Witt, Mallory D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Witt, Mallory D.] Harbor UCLA Med Ctr, Los Angeles, CA USA. RP Brown, TT (reprint author), 1830 East Monument St,Suite 333, Baltimore, MD 21287 USA. EM tbrown27@jhmi.edu FU NCCAM [K23-AT2862]; NIAID [R01-AI093520]; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung and Blood Institute [UO1-AI-35042, UL1-RR025005, UO1-AI-35043, UO1-AI-35039, UO1-AI-35040, UO1-AI-35041, R03-DA-026038, M01 RR00425]; Johns Hopkins Bayview Advanced Chemistry Laboratory [NIH ICTR 5UL1RR025005] FX This work was supported by K23-AT2862 (NCCAM) and R01-AI093520 (NIAID) (T. T. B.). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute and the National Heart, Lung and Blood Institute: UO1-AI-35042, UL1-RR025005, UO1-AI-35043, UO1-AI-35039, UO1-AI-35040, UO1-AI-35041, R03-DA-026038, M01 RR00425 (GCRC), and the Johns Hopkins Bayview Advanced Chemistry Laboratory (NIH ICTR 5UL1RR025005). NR 53 TC 11 Z9 11 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 2013 VL 29 IS 8 BP 1138 EP 1145 DI 10.1089/aid.2013.0020 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 185EW UT WOS:000321949400007 PM 23550976 ER PT J AU Arciero, CA Henry, LR Howard, RS Peoples, GE Bilchik, AJ Avital, I Buckenmaier, CC Stojadinovic, A AF Arciero, Cletus A. Henry, Leonard R. Howard, Robin S. Peoples, George E. Bilchik, Anton J. Avital, Itzhak Buckenmaier, Chester C., III Stojadinovic, Alexander TI Technical Effects of Adding 1 % Lidocaine to Technetium Sulfur Colloid for Sentinel Lymphatic Mapping in Early Breast Cancer: Analysis of Data from a Double-blind Randomized Controlled Trial SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article ID NODE BIOPSY; AXILLARY DISSECTION; LYMPHADENECTOMY; HYDROCHLORIDE; STABILITY; INJECTION; RESECTION; MELANOMA; MIXTURE AB A practice standard in sentinel lymph node (SLN) mapping in breast cancer is intradermal injection of technetium-99m sulfur colloid (Tc-99m), resulting in significant patient discomfort and pain. A previous randomized controlled trial showed that adding lidocaine to Tc-99m significantly reduced radioisotope injection-related pain. We tested whether 1 % lidocaine admixed with Tc-99m affects feasibility of SLN mapping. Between January 2006 and April 2009, 140 patients with early breast cancer were randomly assigned (1:1:1:1) to receive standard topical 4 % lidocaine cream and intradermal Tc-99m (control) or to one of three other study groups: topical placebo cream and injection of Tc-99m containing sodium bicarbonate (NaHCO3), 1 % lidocaine, or both. All SLN data were collected prospectively. Study groups were comparable for clinicopathological parameters. As previously reported, the addition of 1 % lidocaine to the radioisotope solution significantly improved patient comfort. Overall SLN identification rate in the trial was 93 %. Technical aspects of SLN biopsy were similar for all groups, including time from injection to operation, first SLN (SLN 1) gamma probe counts, ex vivo counts for SLN 1 and SLN 2, and axillary bed counts. SLN identification rates were comparable statistically: control (96 %), lidocaine (90 %), sodium bicarbonate (97 %), and sodium bicarbonate-lidocaine (90 %). The control group had a significantly higher SLN 2/SLN 1 ex vivo count ratio, and the number of SLNs detected was significantly reduced in the lidocaine versus no-lidocaine groups (p < 0.05). Addition of 1 % lidocaine to standard radioisotope solution for SLN mapping in breast cancer is associated with fewer SLNs detected, but it does not appear to compromise SLN identification. C1 [Arciero, Cletus A.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. [Henry, Leonard R.] Indiana Univ Hlth, Goshen Ctr Canc, Div Surg Oncol, Goshen, IN USA. [Howard, Robin S.] Walter Reed Natl Mil Med Ctr, Dept Res Programs, Biostat Sect, Bethesda, MD USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Peoples, George E.; Bilchik, Anton J.; Stojadinovic, Alexander] US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. [Bilchik, Anton J.] John Wayne Canc Inst, Santa Monica, CA USA. [Bilchik, Anton J.] Calif Oncol Res Inst, Santa Monica, CA USA. [Avital, Itzhak] Bon Secours Canc Inst, Richmond, VA USA. [Buckenmaier, Chester C., III] Def & Vet Ctr Integrat Pain Management, Rockville, MD USA. [Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD USA. [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Stojadinovic, A (reprint author), US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. EM stojadinovicmd2011@gmail.com FU John P. Murtha Neuroscience and Pain Institute; Clinical Breast Care Project; United States Military Cancer Institute FX We acknowledge Tiffany Felix and Nancy Kwon for their invaluable assistance, Col. Craig D. Shriver for his leadership, and the Henry M. Jackson Foundation for the Advancement of Military Medicine. We are grateful to the members and staff of the Army Regional Anesthesia and Pain Management Initiative, United States Military Cancer Institute, and the Clinical Breast Care Project for their consistent support of this collaborative research effort. Supported in part by the John P. Murtha Neuroscience and Pain Institute, the Clinical Breast Care Project, and the United States Military Cancer Institute. NR 16 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD AUG PY 2013 VL 20 IS 8 BP 2548 EP 2555 DI 10.1245/s10434-013-2912-y PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 180CH UT WOS:000321570000015 PM 23443947 ER PT J AU Espinosa, DA Yadava, A Angov, E Maurizio, PL Ockenhouse, CF Zavalaa, F AF Espinosa, Diego A. Yadava, Anjali Angov, Evelina Maurizio, Paul L. Ockenhouse, Christian F. Zavalaa, Fidel TI Development of a Chimeric Plasmodium berghei Strain Expressing the Repeat Region of the P. vivax Circumsporozoite Protein for In Vivo Evaluation of Vaccine Efficacy SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA PARASITES; T-CELL; FALCIPARUM; PROTECTION; EPITOPES; ANTIBODIES; STAGE; TRANSMISSION; MOSQUITO; IMMUNITY AB The development of vaccine candidates against Plasmodium vivax-the most geographically widespread human malaria species-is challenged by technical difficulties, such as the lack of in vitro culture systems and availability of animal models. Chimeric rodent Plasmodium parasites are safe and useful tools for the preclinical evaluation of new vaccine formulations. We report the successful development and characterization of chimeric Plasmodium berghei parasites bearing the type I repeat region of P. vivax circumsporozoite protein (CSP). The P. berghei-P. vivax chimeric strain develops normally in mosquitoes and produces highly infectious sporozoites that produce patent infection in mice that are exposed to the bites of as few as 3 P. berghei-P. vivax-infected mosquitoes. Using this transgenic parasite, we demonstrate that monoclonal and polyclonal antibodies against P. vivax CSP strongly inhibit parasite infection and thus support the notion that these antibodies play an important role in protective immunity. The chimeric parasites we C1 [Espinosa, Diego A.; Maurizio, Paul L.; Zavalaa, Fidel] Johns Hopkins Univ, Johns Hopkins Malaria Res Inst, Baltimore, MD 21218 USA. [Espinosa, Diego A.; Maurizio, Paul L.; Zavalaa, Fidel] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Yadava, Anjali; Angov, Evelina; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. RP Zavalaa, F (reprint author), Johns Hopkins Univ, Johns Hopkins Malaria Res Inst, Baltimore, MD 21218 USA. EM fzavala@jhsph.edu RI Maurizio, Paul/B-7747-2013; OI Maurizio, Paul/0000-0002-5859-6260; Espinosa, Diego A./0000-0002-4364-5031 FU National Institutes of Health [AI44375]; Bloomberg Family Foundation FX F.Z. is supported by National Institutes of Health grant AI44375. We are grateful for the support of the Bloomberg Family Foundation. NR 37 TC 10 Z9 10 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2013 VL 81 IS 8 BP 2882 EP 2887 DI 10.1128/IAI.00461-13 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 180TY UT WOS:000321622700024 PM 23716612 ER PT J AU Klafehn, J Li, CC Chiu, CY AF Klafehn, Jennifer Li, Chenchen Chiu, Chi-yue TI To Know or Not to Know, Is That the Question? Exploring the Role and Assessment of Metacognition in Cross-Cultural Contexts SO JOURNAL OF CROSS-CULTURAL PSYCHOLOGY LA English DT Article DE metacognition; methodology; cultural intelligence; MTMM ID SELF-EFFICACY; FIT INDEXES; INTERNATIONAL STUDENTS; DISCRIMINANT VALIDITY; FUTURE-RESEARCH; INTELLIGENCE; PERSONALITY; PERFORMANCE; ADJUSTMENT; SKILLS AB Findings from research in educational and cognitive psychology have shown that metacognition, defined as the awareness, monitoring, and evaluation of one's knowledge and cognitive processes, exerts substantial influence on individual performance. The majority of this research, however, has only examined metacognitive skill as it applies to academic settings, and has largely overlooked its applications to other contexts, such as cross-cultural performance. To better understand the role of metacognition in cross-cultural contexts, as well as the means by which it should be assessed, two studies were conducted that jointly explored the construct validity of a well-established self-reported measure of metacognition (i.e., the Metacognitive subscale of the Cultural Intelligence Scale; CQS), as well as its relative utility in predicting cross-cultural performance. Results from Study 1 indicated that self-reported metacognition (as measured by the CQS) is distinct from personality, but highly correlated with the other subfacets of self-reported cultural intelligence. Analyses using structural equation modeling (SEM) further revealed that peers (n = 206) were more accurate in rating participants' cultural intelligence than were participants themselves (n = 206). Results from Study 2, which explored the criterion-related validity of the Metacognitive subscale of the CQS, in particular, demonstrated that self-reported metacognition did not predict international students' adaptation (n = 50). These findings are discussed in light of other research that has called into question the validity of self-reported measures of metacognition, in general. C1 [Klafehn, Jennifer] Univ Illinois, Urbana, IL 61801 USA. [Li, Chenchen; Chiu, Chi-yue] Nanyang Technol Univ, Singapore 639798, Singapore. RP Klafehn, J (reprint author), US Army Res Inst, 6010 Frankford St,Off 221, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.l.klafehn@us.army.mil NR 126 TC 2 Z9 2 U1 18 U2 33 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0022-0221 J9 J CROSS CULT PSYCHOL JI J. Cross-Cult. Psychol. PD AUG PY 2013 VL 44 IS 6 SI SI BP 963 EP 991 DI 10.1177/0022022113492893 PG 29 WC Psychology, Social SC Psychology GA 182LA UT WOS:000321742800007 ER PT J AU Moran, DS Evans, R Arbel, Y Luria, O Hadid, A Yanovich, R Milgrom, C Finestone, AS AF Moran, D. S. Evans, R. Arbel, Y. Luria, O. Hadid, A. Yanovich, R. Milgrom, C. Finestone, A. S. TI Physical and psychological stressors linked with stress fractures in recruit training SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS LA English DT Article DE bone; psychological stress; risk factors; military basic training ID RISK-FACTORS; STRIDE LENGTH; PREDICTION; PEDOMETER; INJURIES; ACTIGRAPHY; MODEL AB This study aimed to measure ambulation in infantry army basic training, and to evaluate if covering more distance can explain stress fractures in a stressor-stress model. Forty-four male combat recruits (18.7 +/- 0.7 years) participated in a 6-month rigorous high intensity combat training program. Baseline data included anthropometric measurements, VO(2)max, and psychological questionnaires. Actual distance covered was measured using a pedometer over an 11-week training period. Psychological questionnaires were repeated after 2 months. Sixteen recruits were diagnosed with stress fractures by imaging (SFi=36.4%). Statistical analysis included comparing measured variables between SFi and those without stress fractures (NSF). The recruits covered 796 +/- 157km, twofold the distance planned of 378km (P<0.001). The SFi group covered a distance 16.4% greater than that of the NSF group (866 +/- 136 and 744 +/- 161km, respectively, P<0.01), and also demonstrated greater psychological stress. These data reveal the importance of adherence to or enforcement of military training programs. In the light of these data, the Israeli Defense Forces program needs reappraisal. A stressor-stress response might explain the susceptibility of certain recruits for injury. Using advanced technology, monitoring ambulation may prevent stress fracture development by limiting subjects exceeding a certain level. Psychological profile may also play a role in predicting stress fracture development. C1 [Moran, D. S.; Arbel, Y.; Luria, O.; Hadid, A.; Yanovich, R.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, D. S.] Ariel Univ Ctr Samaria, Ariel, Israel. [Evans, R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Milgrom, C.] Hadassah Hebrew Univ Med Ctr, Dept Orthoped Surg, Jerusalem, Israel. [Finestone, A. S.] Assaf HaRofeh Med Ctr, Dept Orthoped Surg, Zerifin, Israel. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il OI Finestone, Aharon/0000-0003-1956-5557 FU Medical Research and Material Command MRMC [W911QY-08-P-0286] FX The study was supported in part by a contract from the Medical Research and Material Command MRMC No. W911QY-08-P-0286. The opinions or the assertions contained here are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army, the Israeli Defense Forces, or the Department of Defense. The authors have no conflict of interest to disclose. NR 40 TC 5 Z9 5 U1 2 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0905-7188 J9 SCAND J MED SCI SPOR JI Scand. J. Med. Sci. Sports PD AUG PY 2013 VL 23 IS 4 BP 443 EP 450 DI 10.1111/j.1600-0838.2011.01420.x PG 8 WC Sport Sciences SC Sport Sciences GA 182QZ UT WOS:000321760100013 PM 22107354 ER PT J AU Morrison, JJ Ross, JD Poon, H Midwinter, MJ Jansen, JO AF Morrison, J. J. Ross, J. D. Poon, H. Midwinter, M. J. Jansen, J. O. TI Intra-operative correction of acidosis, coagulopathy and hypothermia in combat casualties with severe haemorrhagic shock SO ANAESTHESIA LA English DT Article ID DAMAGE CONTROL RESUSCITATION; IMPROVISED EXPLOSIVE DEVICES; CONTROL LAPAROTOMY; TRANEXAMIC ACID; CONTROL SURGERY; TRAUMA; TRANSFUSION; SURVIVAL AB We assessed acidosis, coagulopathy and hypothermia, before and after surgery in 51 combat troops operated on for severe blast injury. Patients were transfused a median (IQR [range]) of 27 (17-38 [5-84]) units of red cell concentrate, 27 (16-38 [4-83]) units of plasma, 2.0 (0.5-3.5 [0-13.0]) units of cryoprecipitate and 4 (2-6 [0-17]) pools of platelets. The pH, base excess, prothrombin time and temperature increased: from 7.19 (7.10-7.29 [6.50-7.49]) to 7.45 (7.40-7.51 [7.15-7.62]); from -9.0 (-13.5 to -4.5 [-28 to -2]) mmol.l(-1) to 4.5 (1.0-8.0 [-7 to +11])mmol.l(-1); from 18 (15-21 [9-24]) s to 14 (11-18 [9-21])s; and from 36.1 (35.1-37.1 [33.0-38.1]) degrees C to 37.4 (37.0-37.9 [36.0-38.0])degrees C, respectively. Contemporary intra-operative resuscitation strategies can normalise the physiological derangements caused by haemorrhagic shock. C1 [Morrison, J. J.; Midwinter, M. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, J. J.] US Army Inst Surg Res, San Antonio, TX USA. [Ross, J. D.] Trauma & Clin Care Res, Med Wing 59, Sci & Technol Off, Joint Base San Antonio L, TX USA. [Jansen, J. O.] Aberdeen Royal Infirm, Dept Surg, Colchester, Essex, England. [Jansen, J. O.] Aberdeen Royal Infirm, Dept Intens Care Med, Aberdeen, Scotland. RP Jansen, JO (reprint author), 144 Parachute Med Squadron,16 Air Assault Med Reg, Colchester, Essex, England. EM jan.jansen@nhs.net RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 27 TC 16 Z9 17 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0003-2409 J9 ANAESTHESIA JI Anaesthesia PD AUG PY 2013 VL 68 IS 8 BP 846 EP 850 DI 10.1111/anae.12316 PG 5 WC Anesthesiology SC Anesthesiology GA 180JP UT WOS:000321590300013 PM 23724784 ER PT J AU Meeks, JJ Walker, M Bernstein, M Kent, M Eastham, JA AF Meeks, Joshua J. Walker, Marc Bernstein, Melanie Kent, Matthew Eastham, James A. TI Accuracy of post-radiotherapy biopsy before salvage radical prostatectomy SO BJU INTERNATIONAL LA English DT Article DE prostate biopsy; prostate cancer; radiation therapy; radical prostatectomy ID RADIATION-THERAPY; CANCER; ANTIGEN; GRADE AB Objective To determine whether post-radiotherapy (RT) biopsy (PRB) adequately predicts the presence, location, and histological features of cancer in the salvage radical prostatectomy (SRP) specimen. Before salvage treatment, a PRB is required to confirm the presence of locally recurrent or persistent cancer and to determine the extent and location of the prostate cancer. Patients and Methods SRP was performed between 1998 and 2011 on 198 patients. All patients underwent a PRB. PRB and SRP specimens were evaluated by a genitourinary pathologist. Patients had external-beam RT alone (EBRT; 71%) or brachytherapy with or without EBRT (29%). Results Of the men undergoing SRP, 26 (14%) were clinical stage >= T3, with 13% of PRBs with Gleason score >= 8. Cancer was unilateral in 120 (61%) biopsies, with contralateral or bilateral prostate cancer at SRP in 49%. In the SRP specimen, cancer was multifocal in 57%. Cancer was upgraded at SRP in 58% of men, with 20% having an increase in primary Gleason grade. The accuracy of PRB varied by region from 62% to 76%, with undetected cancers ranging from 12% to 26% and most likely to occur at the mid-gland. Conclusions Radiation-recurrent prostate cancers were often multifocal, and biopsy missed up to 20% of tumours. More than half of the cancers were upgraded at SRP, and many that were unilateral on PRB were bilateral at SRP. C1 [Meeks, Joshua J.; Bernstein, Melanie; Eastham, James A.] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10021 USA. [Kent, Matthew] Mem Sloan Kettering Canc Ctr, Dept Biostat & Epidemiol, New York, NY 10021 USA. [Walker, Marc] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. RP Eastham, JA (reprint author), Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, 353 East 68th St, New York, NY 10021 USA. EM easthamj@mkscc.org OI Bernstein, Melanie/0000-0002-0681-6188 NR 16 TC 6 Z9 6 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-4096 J9 BJU INT JI BJU Int. PD AUG PY 2013 VL 112 IS 3 BP 308 EP 312 DI 10.1111/bju.12015 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 178FI UT WOS:000321429800011 PM 23490232 ER PT J AU Ren, F Mattus, CH Wang, JJA DiPaolo, BP AF Ren, Fei Mattus, Catherine H. Wang, John Jy-An DiPaolo, Beverly P. TI Effect of projectile impact and penetration on the phase composition and microstructure of high performance concretes SO CEMENT & CONCRETE COMPOSITES LA English DT Article DE High performance concrete; Microstructure; SEM; X-ray diffraction ID REACTIVE POWDER CONCRETE; HIGH-STRENGTH CONCRETE; MECHANICAL-PROPERTIES; MINERAL ADMIXTURES; FIBER; POLYPROPYLENE; RESISTANCE AB As a result of increased concerns regarding public safety in recent years, the impact and penetration resistance of infrastructure has become an emerging research focus in the cement and concrete industry. Ultra-high performance concretes (UHPCs) with fiber reinforcement usually possess compressive strengths greater than 200 MPa and are promising candidates for penetration-resistant building materials. In the current project, two UHPC materials, ERDC-M (a modified composition developed at U.S. Army Engineer Research and Development Center) and Ductal (R), were subjected to projectile penetration testing. The microstructural evolution due to projectile impact and penetration was examined via scanning electron microscopy and X-ray diffraction. Possible phase changes were observed in the affected material volume, which can be interpreted as resulting from the high temperature and high pressure induced by the impact and penetration. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Ren, Fei; Wang, John Jy-An] Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. [Mattus, Catherine H.] Oak Ridge Natl Lab, Energy & Transportat Sci Div, Oak Ridge, TN 37831 USA. [DiPaolo, Beverly P.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Wang, JJA (reprint author), Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. EM wangja@ornl.gov RI Mattus, Catherine/E-5591-2017; OI Mattus, Catherine/0000-0002-4574-1588; Wang, Jy-An/0000-0003-2402-3832 FU Oak Ridge National Laboratory [DE-AC05-00OR22725]; UT-Battelle, LLC; Department of Homeland Security, Science and Technology Directorate, Infrastructure Protection and Disaster Management Division; Geotechnical and Structures Laboratory, ERDC FX This research was carried out at Oak Ridge National Laboratory under contract DE-AC05-00OR22725 with UT-Battelle, LLC. This work was sponsored by the Department of Homeland Security, Science and Technology Directorate, Infrastructure Protection and Disaster Management Division: Dr. John Fortune and Ms. Mila Kennett, Program Managers. The authors wish to extend our appreciation to the Concrete and Materials Branch - ERDC personnel for their diligent efforts in specimen preparation and quasi-static, unconfined compression testing and to Drs. William D. Reinhart and Tom F. Thornhill at the Sandia National Laboratories for the impact and penetration tested specimen panels. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, ERDC. Approved for public release; distribution is unlimited. NR 23 TC 2 Z9 2 U1 0 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0958-9465 J9 CEMENT CONCRETE COMP JI Cem. Concr. Compos. PD AUG PY 2013 VL 41 BP 1 EP 8 DI 10.1016/j.cemconcomp.2013.04.007 PG 8 WC Construction & Building Technology; Materials Science, Composites SC Construction & Building Technology; Materials Science GA 177XM UT WOS:000321408700001 ER PT J AU Yerry, JA Finkel, AG Lewis, SC Kuehn, DR AF Yerry, J. A. Finkel, A. G. Lewis, S. C. Kuehn, D. R. TI Onabotulinum Toxin A for the Treatment of Chronic Post-Traumatic Headache in Service Members with a History of Mild Traumatic Brain Injury SO CEPHALALGIA LA English DT Meeting Abstract CT International Headache Congress CY JUN 27-30, 2013 CL Boston, MA SP Int Headache Soc, Amer Headache Soc C1 [Yerry, J. A.; Finkel, A. G.; Lewis, S. C.; Kuehn, D. R.] Womack Army Med Ctr, Ft Bragg, NC USA. [Finkel, A. G.] Carolina Headache Inst, Chapel Hill, NC USA. [Finkel, A. G.] Univ N Carolina, Chapel Hill, NC USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0333-1024 J9 CEPHALALGIA JI Cephalalgia PD AUG PY 2013 VL 33 IS 11 BP 984 EP 985 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 176VJ UT WOS:000321333800059 ER PT J AU Morizot, G Kendjo, E Mouri, O Thellier, M Perignon, A Foulet, F Cordoliani, F Bourrat, E Laffitte, E Alcaraz, I Bodak, N Ravel, C Vray, M Grogl, M Mazier, D Caumes, E Lachaud, L Buffet, PA AF Morizot, G. Kendjo, E. Mouri, O. Thellier, M. Perignon, A. Foulet, F. Cordoliani, F. Bourrat, E. Laffitte, E. Alcaraz, I. Bodak, N. Ravel, C. Vray, M. Grogl, M. Mazier, D. Caumes, E. Lachaud, L. Buffet, P. A. CA Cutaneous Leishmaniasis French TI Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE cutaneous leishmaniasis; systemic antimony; intralesional antimony; liposomal amphotericin B; miltefosine ID INTRALESIONAL MEGLUMINE ANTIMONIATE; LIPOSOMAL AMPHOTERICIN-B; SODIUM STIBOGLUCONATE; NEW-WORLD; MUCOSAL LEISHMANIASIS; COMBINED CRYOTHERAPY; CLINICAL-TRIAL; EFFICACY; FLUCONAZOLE; MILTEFOSINE AB Background. Cutaneous leishmaniasis (CL) is a disfiguring but not life-threatening disease. Because antileishmanial drugs are potentially toxic, the World Health Organization (WHO) recommends simple wound care or local therapy as first-line treatment, followed or replaced by systemic therapy if local therapy fails or cannot be performed. Methods. To determine the feasibility and impact of the recommended approach, we analyzed the results of a centralized referral treatment program in 135 patients with parasitologically proven CL. Results. Infections involved 10 Leishmania species and were contracted in 29 different countries. Eighty-four of 135 patients (62%) were initially treated without systemic therapy. Of 109 patients with evaluable charts, 23 of 25 (92%) treated with simple wound care and 37 of 47 (79%) treated with local antileishmanial therapy were cured by days 42-60. In 37 patients with large or complex lesions, or preexisting morbidities, or who had not been cured with local therapy, the cure rate with systemic antileishmanial agents was 60%. Systemic adverse events were observed in 15 patients, all receiving systemic therapy. Conclusions. In this population of CL patients displaying variable degrees of complexity and severity, almost two-thirds of patients could be initially managed without systemic therapy. Of these, 60 were cured before day 60. The WHO-recommended stepwise approach favoring initial local therapy therefore resulted in at least 44% of all patients being cured without exposure to the risk of systemic adverse events. Efforts are needed to further simplify local therapy of CL and to improve the management of patients with complex lesions and/or preexisting comorbidities. C1 [Morizot, G.; Buffet, P. A.] Inst Pasteur, Unite Immunol Mol Parasites, Paris, France. [Kendjo, E.; Mouri, O.; Thellier, M.; Mazier, D.; Buffet, P. A.] Hop La Pitie Salpetriere, Serv Parasitol Mycol, Paris, France. [Perignon, A.; Caumes, E.] Hop La Pitie Salpetriere, Serv Malad Infect & Trop, Paris, France. [Ravel, C.; Lachaud, L.] French Reference Ctr Leishmaniasis, Montpellier, France. [Foulet, F.] Hop Henri Mondor, Serv Parasitol Mycol, F-94010 Creteil, France. [Cordoliani, F.; Bourrat, E.] Hop St Louis, Serv Dermatol, F-75475 Paris, France. [Bourrat, E.] Hop Robert Debre, Serv Pediat Gen, F-75019 Paris, France. [Laffitte, E.] Hop Univ Geneve, Clin Dermatol, Geneva, Switzerland. [Alcaraz, I.] Hop Gustave Dron, Serv Malad Infect & Pathol Voyageur, Tourcoing, France. [Bodak, N.] Hop Necker Enfants Malad, Serv Dermatol, Paris, France. [Vray, M.] Inst Pasteur Paris INSERM, Unite Rech & Expertise Epidemiol Malad Emergentes, Paris, France. [Grogl, M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Buffet, P. A.] Univ Paris 06, UMRs INSERM 945, F-75252 Paris 05, France. RP Buffet, PA (reprint author), Grp Hosp Pitie Salpetriere, 47 Blvd Hop, F-75651 Paris 13, France. EM pierre.buffet@psl.aphp.fr RI Ravel, Christophe/A-7369-2008; Gangneux, Jean-Pierre/J-2960-2015; OI Thellier, Marc/0000-0003-4867-2423 NR 51 TC 20 Z9 20 U1 0 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 1 PY 2013 VL 57 IS 3 BP 370 EP 380 DI 10.1093/cid/cit269 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 182IA UT WOS:000321733700009 PM 23633111 ER PT J AU Sul, YT Kwon, DH Kang, BS Oh, SJ Johansson, C AF Sul, Young-Taeg Kwon, David H. Kang, Byung-Soo Oh, Se-Jung Johansson, Carina TI Experimental evidence for interfacial biochemical bonding in osseointegrated titanium implants SO CLINICAL ORAL IMPLANTS RESEARCH LA English DT Article DE biochemical bonding theory; bone and titanium implant interface; osseointegration mechanism; surface chemistry and topography ID SURFACE-PROPERTIES; BONE RESPONSE; IN-VIVO; OXIDIZED TITANIUM; CRYSTAL-STRUCTURE; OXIDE THICKNESS; CHEMISTRY; ROUGHNESS; STRENGTH; PERFORMANCE AB Objectives: (i) To identify and quantify an interfacial biochemical bond and the bonding strength of osseointegrated implants with bioactive titanium oxide chemistry, ATiOxB (A, metal cations; TiOx, titanium oxides/hydroxides; B, non-metal anions) and (ii) to provide quantitative evidence for the biochemical bond theory of osseointegration proposed by Sul etal. for description and explanation of why and how the implants with ATiO(x)B surface oxide chemistry may exhibit a significantly stronger bone response, in spite of the fact that the roughness values approached zero, or were equivalent to or significantly lower than those of the control implants. Materials and methods: We applied a newly developed biochemical bond measurement (BBM) method to model implant surfaces that were perfectly smooth nanotopography near-zero roughness as the constant parameter, and used the bioactive surface chemistry of titanium oxide, ATiO(x)B chemistry as a variable parameter in rabbit tibiae for 10weeks. In this manner, we determined an interfacial biochemical bond and quantified its bonding strength. Results: The increase in biochemical bond strengths of the test implant relative to the control implant was determined to be 0.018 (+/- 0.008) MPa (0.031 vs 0.021 MPa, n=10) for tensile strength and 8.9 (+/- 6.1) Ncm (33.0 vs 24.1 Ncm, n=10) for removal torque. Tensile and removal torque show strong correlation in the Pearson test (r=0.901, P0.001). In addition, histomorphometric measurements including bone-to-metal-contact (BMC, P=0.007), bone area and newly formed bone showed significant increases in the mean values for ATiO(x)B chemistry (P=0.007, n=10). Biochemical bond theory states that the surface oxide chemistry, ATiO(x)B must have more electrical and chemical molecular polarity that fractionally charges the surfaces denoted as (+) and (-) and leads to electrostatic and electrodynamic interactions with the bone healing cascade, eventually leading to the formation of biochemical bonding at the bone/implant interface. Conclusions: The present study has provided quantitative evidence for biochemical bond theory of osseointegration of implants with bioactive surface oxide chemistry, ATiO(x)B. The theory of biochemical bonds may provide a scientific rationale pertinent to recent emerging trends and technologies for surface chemistry modifications of implants. C1 [Sul, Young-Taeg] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, SE-41346 Gothenburg, Sweden. [Sul, Young-Taeg] Korea Univ, Inst Clin Dent Res, Seoul, South Korea. [Kwon, David H.] US Army Adv Educ Program Gen Dent, Ft Bragg, NC USA. [Oh, Se-Jung] Seoul Natl Univ, Dept Phys & Astron, Seoul, South Korea. [Johansson, Carina] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Prosthodont Dent Mat Sci, SE-41346 Gothenburg, Sweden. RP Sul, YT (reprint author), Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, Arvid Wallgrens Backe 20,Box 412, SE-41346 Gothenburg, Sweden. EM young-taeg.sul@biomaterials.gu.se FU Ministry of Education, Science and Technology, Republic of Korea [2010-0020654]; Swedish Medical Research Council FX We acknowledge research grants from the Biotechnology Development Project (2010-0020654) from the Ministry of Education, Science and Technology, Republic of Korea, and the Swedish Medical Research Council. NR 44 TC 11 Z9 11 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0905-7161 J9 CLIN ORAL IMPLAN RES JI Clin. Oral Implant. Res. PD AUG PY 2013 VL 24 SU A100 BP 8 EP 19 DI 10.1111/j.1600-0501.2011.02355.x PG 12 WC Dentistry, Oral Surgery & Medicine; Engineering, Biomedical SC Dentistry, Oral Surgery & Medicine; Engineering GA 185JR UT WOS:000321964400002 PM 22093014 ER PT J AU Beyaz, MI Hanrahan, B Feldman, J Ghodssi, R AF Beyaz, Mustafa Ilker Hanrahan, Brendan Feldman, Jeremy Ghodssi, Reza TI Monitoring of Actuation Conditions in a Micro-Turbo-Generator SO IEEE SENSORS JOURNAL LA English DT Article DE Micro generator; turbogenerator; actuation conditions; integrated sensing; power MEMS ID PERMANENT-MAGNET GENERATORS; AXIAL-FLUX; DESIGN AB This paper presents the theory and implementation of an integrated sensing technique for the real-time measurement of applied actuation conditions in a micro-turbo-generator. The device is composed of a microturbine rotor with magnetic components and a stator with planar coils for electromagnetic induction. While the rotor is actuated with pressurized nitrogen, the induced voltages are extracted to generate and deliver electrical power as well as to monitor the pneumatic actuation parameters. It is demonstrated that the rotor speed, applied gas flow rate, and pressure show repeatable high linearity with respect to voltage frequency and amplitude in different devices. Sensitivity values of 83 Hz/krpm, 140 Hz/slm, and 1428 Hz/psi together with R-2 values larger than 0.97 are achieved. The integrated sensing technique presented in this paper will eliminate the need for external sensing components in continuous device screening, and lead to closed-loop control for autonomous tuning of desired operating conditions in rotary microgenerators. C1 [Beyaz, Mustafa Ilker; Hanrahan, Brendan; Feldman, Jeremy; Ghodssi, Reza] Univ Maryland, College Pk, MD 20742 USA. [Hanrahan, Brendan] US Army Res Lab, Adelphi, MD 20783 USA. [Beyaz, Mustafa Ilker] Antalya Int Univ, Dept Elect & Elect Engn, TR-07190 Antalya, Turkey. RP Beyaz, MI (reprint author), Antalya Int Univ, Dept Elect & Elect Engn, TR-07190 Antalya, Turkey. EM mibeyaz@antalya.edu.tr; bhanrah@gmail.com; jfn@umd.edu; ghodssi@umd.edu FU U.S. National Science Foundation [0901411] FX This work was supported by the U.S. National Science Foundation under Award 0901411. The associate editor coordinating the review of this paper and approving it for publication was Prof. Weileun Fang. NR 14 TC 2 Z9 3 U1 0 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD AUG PY 2013 VL 13 IS 8 BP 2937 EP 2943 DI 10.1109/JSEN.2013.2259477 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 181KS UT WOS:000321667100006 ER PT J AU Korenkov, M Linkov, F Lincov, I AF Korenkov, M. Linkov, F. Lincov, I. TI Multi-Criteria Decision Analysis Model for Assessing Risks of Alternative Bariatric Procedures SO OBESITY SURGERY LA English DT Meeting Abstract CT 18th World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disord ers (IFSO) CY AUG 28-31, 2013 CL Istanbul, TURKEY SP Int Federat Surg Obes & Metab Disorders (IFSO) C1 [Korenkov, M.] Teaching Hosp Eschwege, Eschwege, Germany. [Linkov, F.] Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15213 USA. [Lincov, I.] US Army, Engineer Res & Dev Ctr, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0960-8923 J9 OBES SURG JI Obes. Surg. PD AUG PY 2013 VL 23 IS 8 BP 1182 EP 1182 PG 1 WC Surgery SC Surgery GA 177QC UT WOS:000321389200618 ER PT J AU Weingarten, NS Chung, PW AF Weingarten, N. Scott Chung, Peter W. TI a-Type edge dislocation mobility in wurtzite GaN using molecular dynamics SO SCRIPTA MATERIALIA LA English DT Article DE Gallium nitride; Molecular dynamics; Dislocations; Mobility ID THREADING DISLOCATIONS; GROWTH; SAPPHIRE; STRENGTH; CRYSTAL AB Classical molecular dynamics simulations of wurtzite gallium nitride are performed to calculate the velocities of the three types of a-type edge dislocations at 1300 K. Slips in the basal, prismatic and pyramidal planes are studied, and the anisotropic glide mechanisms are examined at both low and high stresses. The structures of the dislocation cores are described and the mechanisms of dislocation glide are discussed in the context of their potential motion in thin film growth. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Weingarten, N. Scott] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Chung, Peter W.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Weingarten, NS (reprint author), US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM neil.s.weingarten.civ@mail.mil FU Army Research Laboratory; Army Program Element for Defense Research Sciences [0601102A H44 06] FX Financial support for this work was granted in part by the Director's Research Initiative program at the Army Research Laboratory and Army Program Element 0601102A H44 06 for Defense Research Sciences. Computer support was provided by the DoD Supercomputing Resource Centers at ARL and AFRL. NR 24 TC 7 Z9 7 U1 4 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD AUG PY 2013 VL 69 IS 4 BP 311 EP 314 DI 10.1016/j.scriptamat.2013.05.005 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 178CP UT WOS:000321422000008 ER PT J AU Wright, RW Haas, AK Huston, LJ Ross, JR Harris, D Patel, K Pearson, D Tarabichi, M Ying, D Steger-May, K Albright, JP Allen, CR Amendola, A Anderson, AF Andrish, JT Annunziata, CC Arciero, RA Bach, BR Baker, CL Bartolozzi, AR Baumgarten, KM Bechler, JR Berg, JH Bernas, G Brockmeier, SF Brophy, RH Bush-Joseph, CA Butler, JB Campbell, JD Carey, JL Carpenter, JE Cole, BJ Cooper, DE Cooper, JM Cox, CL Creighton, RA Dahm, DL David, TS DeBerardino, TM Dunn, WR Flanigan, DC Frederick, RW Ganley, TJ Gatt, CJ Gecha, SR Giffin, JR Hame, SL Hannafin, JA Harner, CD Harris, NL Hechtman, KS Hershman, EB Hoellrich, RG Hosea, TM Johnson, DC Johnson, TS Jones, MH Kaeding, CC Kamath, GV Klootwyk, TE Lantz, BA Levy, BA Ma, CB Maiers, GP Mann, B Marx, RG Matava, MJ Mathien, GM McAllister, DR McCarty, EC McCormack, RG Miller, BS Motamedi, AR Nissen, CW O'Neill, DF Owens, BD Parker, RD Purnell, ML Ramappa, AJ Rauh, MA Rettig, A Sekiya, JK Shea, KG Sherman, OH Slauterbeck, JR Smith, MV Spang, JT Spindler, KP Stuart, MJ Svoboda, SJ Taft, TN Tenuta, JJ Tingstad, EM Vidal, AF Viskontas, DG White, RA Williams, JS Wolcott, ML Wolf, BR York, JJ AF Wright, Rick W. Haas, Amanda K. Huston, Laura J. Ross, James R. Harris, David Patel, Kushal Pearson, David Tarabichi, Majd Ying, David Steger-May, Karen Albright, John P. Allen, Christina R. Amendola, Annunziato (Ned) Anderson, Allen F. Andrish, Jack T. Annunziata, Christopher C. Arciero, Robert A. Bach, Bernard R., Jr. Baker, Champ L., III Bartolozzi, Arthur R. Baumgarten, Keith M. Bechler, Jeffery R. Berg, Jeffrey H. Bernas, Geoffrey Brockmeier, Stephen F. Brophy, Robert H. Bush-Joseph, Charles A. Butler, J. Brad Campbell, John D. Carey, James L. Carpenter, James E. Cole, Brian J. Cooper, Daniel E. Cooper, Jonathan M. Cox, Charles L. Creighton, R. Alexander Dahm, Diane L. David, Tal S. DeBerardino, Thomas M. Dunn, Warren R. Flanigan, David C. Frederick, Robert W. Ganley, Theodore J. Gatt, Charles J., Jr. Gecha, Steven R. Giffin, James Robert Hame, Sharon L. Hannafin, Jo A. Harner, Christopher D. Harris, Norman Lindsay, Jr. Hechtman, Keith S. Hershman, Elliott B. Hoellrich, Rudolf G. Hosea, Timothy M. Johnson, David C. Johnson, Timothy S. Jones, Morgan H. Kaeding, Christopher C. Kamath, Ganesh V. Klootwyk, Thomas E. Lantz, Brett (Brick) A. Levy, Bruce A. Ma, C. Benjamin Maiers, G. Peter Mann, Barton Marx, Robert G. Matava, Matthew J. Mathien, Gregory M. McAllister, David R. McCarty, Eric C. McCormack, Robert G. Miller, Bruce S. Motamedi, Ali R. Nissen, Carl W. O'Neill, Daniel F. Owens, Brett D. Parker, Richard D. Purnell, Mark L. Ramappa, Arun J. Rauh, Michael A. Rettig, Arthur Sekiya, Jon K. Shea, Kevin G. Sherman, Orrin H. Slauterbeck, James R. Smith, Matthew V. Spang, Jeffrey T. Spindler, Kurt P. Stuart, Michael J. Svoboda, Steven J. Taft, Timothy N. Tenuta, Joachim J. Tingstad, Edwin M. Vidal, Armando F. Viskontas, Darius G. White, Richard A. Williams, James S., Jr. Wolcott, Michelle L. Wolf, Brian R. York, James J. CA MARS Grp TI Radiographic Findings in Revision Anterior Cruciate Ligament Reconstructions from the MARS Cohort SO JOURNAL OF KNEE SURGERY LA English DT Article DE anterior cruciate ligament; reconstruction; revision; radiographs ID TIBIAL TUNNEL PLACEMENT; WEIGHT-BEARING RADIOGRAPH; INTERCONDYLAR ROOF; ACL RECONSTRUCTION; GRAFT IMPINGEMENT; CORONAL PLANE; KNEE; OSTEOARTHRITIS; POSITION; FLEXION AB The Multicenter ACL (anterior cruciate ligament) Revision Study (MARS) group was developed to investigate revision ACL reconstruction outcomes. An important part of this is obtaining and reviewing radiographic studies. The goal for this radiographic analysis is to establish radiographic findings for a large revision ACL cohort to allow comparison with future studies. The study was designed as a cohort study. Various established radiographic parameters were measured by three readers. These included sagittal and coronal femoral and tibial tunnel position, joint space narrowing, and leg alignment. Inter-and intraobserver comparisons were performed. Femoral sagittal position demonstrated 42% were more than 40% anterior to the posterior cortex. On the sagittal tibia tunnel position, 49% demonstrated some impingement on full-extension lateral radiographs. Limb alignment averaged 43% medial to the medial edge of the tibial plateau. On the Rosenberg view (45-degree flexion view), theminimum joint space in the medial compartment averaged 106% of the opposite knee, but it ranged down to a minimum of 4.6%. Lateral compartment narrowing at its minimum on the Rosenberg view averaged 91.2% of the opposite knee, but it ranged down to a minimum of 0.0%. On the coronal view, verticality as measured by the angle from the center of the tibial tunnel aperture to the center of the femoral tunnel aperture measured 15.8 degree +/- 6.9% from vertical. This study represents the radiographic findings in the largest revision ACL reconstruction series ever assembled. Findings were generally consistent with those previously demonstrated in the literature. C1 [Wright, Rick W.; Haas, Amanda K.; Harris, David; Pearson, David; Ying, David; Steger-May, Karen; Brophy, Robert H.; Matava, Matthew J.; Smith, Matthew V.] Washington Univ, St Louis, MO 63131 USA. [Huston, Laura J.; Carey, James L.; Cox, Charles L.; Dunn, Warren R.; Spindler, Kurt P.] Vanderbilt Univ, Nashville, TN USA. [Ross, James R.; Carpenter, James E.; Miller, Bruce S.; Sekiya, Jon K.] Univ Michigan, Ann Arbor, MI 48109 USA. [Patel, Kushal] Univ Illinois, Chicago, IL USA. [Tarabichi, Majd] Royal Coll Surgeons Ireland, Dublin 2, Ireland. [Tarabichi, Majd] Royal Coll Surg, Al Sayh, Bahrain. [Albright, John P.; Amendola, Annunziato (Ned); Wolf, Brian R.] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA. [Allen, Christina R.; Ma, C. Benjamin] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Anderson, Allen F.] Tennessee Orthopaed Alliance, Murfreesboro, TN USA. [Andrish, Jack T.; Jones, Morgan H.; Parker, Richard D.; Williams, James S., Jr.] Cleveland Clin, Cleveland, OH USA. [Annunziata, Christopher C.] Commonwealth Orthopaed & Rehab, Exeter, Devon, England. [Arciero, Robert A.; DeBerardino, Thomas M.] Univ Connecticut, Ctr Hlth, Storrs, CT USA. [Bach, Bernard R., Jr.; Bush-Joseph, Charles A.; Cole, Brian J.] Rush Univ, Med Ctr, Chicago, IL USA. [Baker, Champ L., III] Hughston Clin, Dothan, AL USA. [Bartolozzi, Arthur R.] Univ Penn, Hlth Syst, Philadelphia, PA 19104 USA. [Baumgarten, Keith M.] Inst Orthoped, Sioux Falls, SD USA. [Bechler, Jeffery R.; Gatt, Charles J., Jr.; Hosea, Timothy M.] LLC, Univ Orthoped Associates, Fresno, CA USA. [Berg, Jeffrey H.] Town Ctr Orthopaed Associates, Reston, VA USA. [Bernas, Geoffrey; Rauh, Michael A.] SUNY Buffalo, Buffalo, NY 14260 USA. [Brockmeier, Stephen F.] Perry Orthoped & Sports Med, Charlotte, NC USA. [Butler, J. Brad] Orthoped & Fracture Clin, Portland, OR USA. [Campbell, John D.] Bridger Orthopaed & Sports Med, Bozeman, MT USA. [Cooper, Daniel E.] WB Carrell Mem Clin, Dallas, TX USA. [Cooper, Jonathan M.] HlthPartners Specialty Clin, St Paul, MN USA. [Creighton, R. Alexander; Kamath, Ganesh V.; Spang, Jeffrey T.; Taft, Timothy N.] Univ N Carolina Med Ctr, Charlotte, NC USA. [Dahm, Diane L.; Levy, Bruce A.; Stuart, Michael J.] Mayo Clin Rochester, Rochester, MN USA. [David, Tal S.] Arthroscop & Orthoped Sports Med Associates, Pasadena, CA USA. [Flanigan, David C.; Kaeding, Christopher C.] Ohio State Univ, Columbus, OH 43210 USA. [Frederick, Robert W.] Thomas Jefferson Univ, Rothman Inst, Philadelphia, PA USA. [Ganley, Theodore J.] Childrens Hosp Philadelphia, Philadelphia, PA USA. [Gecha, Steven R.] Princeton Orthopaed Associates, Princeton, NJ USA. [Giffin, James Robert] Univ Western Ontario, Fowler Kennedy Sports Med Clin, London, ON N6A 3K7, Canada. [Hame, Sharon L.; McAllister, David R.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Hannafin, Jo A.; Marx, Robert G.] Hosp Special Surg, New York, NY USA. [Harner, Christopher D.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15260 USA. [Harris, Norman Lindsay, Jr.; Purnell, Mark L.] Orthopaed Associates Aspen & Glenwood, Glenwood Springs, CO USA. [Hechtman, Keith S.] UHZ Sports Med Inst, Coral Gables, FL USA. [Hershman, Elliott B.] Lenox Hill Hosp, New York, NY USA. [Hoellrich, Rudolf G.; Lantz, Brett (Brick) A.] Slocum Res & Educ Fdn, Portland, OR USA. [Johnson, David C.; Johnson, Timothy S.] Natl Sports Med Inst, Leesburg, VA USA. [Klootwyk, Thomas E.; Maiers, G. Peter; Rettig, Arthur] Methodist Sports Med Ctr Orthoped Specialists, Houston, TX USA. [Mann, Barton] AOSSM, New York, NY USA. [Mathien, Gregory M.] Knoxville Orthoped Clin, Knoxville, TN USA. [McCarty, Eric C.; Vidal, Armando F.; Wolcott, Michelle L.] Univ Colorado, Denver Sch Med, Boulder, CO 80309 USA. [McCormack, Robert G.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Motamedi, Ali R.] Richmond Bone & Joint Clin, Sugar Land, TX USA. [Nissen, Carl W.] Connecticut Childrens Med Ctr, Hartford, CT USA. [O'Neill, Daniel F.] Littleton Reg Hosp, Littleton, NH USA. [Owens, Brett D.; Svoboda, Steven J.; Tenuta, Joachim J.] US Mil Acad, Keller Army Community Hosp, West Point, NY USA. [Ramappa, Arun J.] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Shea, Kevin G.] Intermt Orthoped, Boston, MA USA. [Sherman, Orrin H.] NYU, Hosp Joint Dis, New York, NY 10003 USA. [Slauterbeck, James R.] Univ Vermont, Coll Med, Burlington, VT 05405 USA. [Tingstad, Edwin M.] Washington State Univ, Inland Orthopaed, Pullman, WA 99164 USA. [Viskontas, Darius G.] Royal Columbian Hosp, New Westminster, BC, Canada. [White, Richard A.] Univ Missouri, Columbia, MO 65211 USA. [York, James J.] Chesapeake Orthopaed & Sports Med Ctr, Chesapeake, VA USA. RP Wright, RW (reprint author), Washington Univ, Sch Med, Dept Orthopaed Surg, 1 Barnes Jewish Hosp Plaza Suite 11300, St Louis, MO 63131 USA. EM rwwright1@aol.com RI Giffin, J. Robert/H-9522-2013 NR 36 TC 2 Z9 2 U1 0 U2 2 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 1538-8506 EI 1938-2480 J9 J KNEE SURG JI J. Knee Surg. PD AUG PY 2013 VL 26 IS 4 BP 239 EP 247 DI 10.1055/s-0032-1329717 PG 9 WC Orthopedics SC Orthopedics GA AW9NN UT WOS:000346584500004 ER PT J AU Hill, CC Gloeb, DJ AF Hill, Christina C. Gloeb, Donald J. TI Military Maternal Weight Trends and Perinatal Outcomes SO MILITARY MEDICINE LA English DT Article ID BODY-MASS INDEX; OBESE WOMEN; DIABETES-MELLITUS; RISK-FACTOR; US ADULTS; PREGNANCY; PREVALENCE; PREECLAMPSIA; PROGRAM; GAIN AB Objective: Obesity is epidemic in the United States and the prevalence is increasing. We sought to determine if the prevalence of obesity in women eligible for health care at military treatment facilities, specifically, active duty (AD) women, is increasing similar to national trends. Methods: Our retrospective cohort study evaluated selected outcomes in women delivering in 1999 and 2006. Women delivering living, singleton, term, nonanomalous neonates in 1999 and 2006 were eligible. Prepregnancy weight and weight gain during pregnancy were compared between the two populations, and data were stratified by AD status, age, and ethnicity. Obstetric outcomes were evaluated based on body mass index (BMI). Results: There were 1,543 and 1,745 mother infant pairs available, respectively, for analysis. Prepregnancy BMI for all women evaluated increased significantly from 1999 to 2006 (25.0 vs. 25.6, p < 0.05). Prepregnancy BMI increased significantly for AD women between 1999 and 2006 (24.3 vs. 25.4, p < 0.05). The prevalence of overweight and obese women increased from 1999 to 2006 in the population evaluated (41.2% vs.46.2%, respectively), and this was demonstrated among all ethnicities. Obesity was associated with increased adverse obstetric outcomes. Conclusion: We demonstrated increasing maternal obesity in a military population over time and associated adverse perinatal outcomes. C1 [Hill, Christina C.; Gloeb, Donald J.] Tripler Army Med Ctr, Honolulu, HI 96825 USA. RP Hill, CC (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96825 USA. NR 39 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2013 VL 178 IS 8 BP 880 EP 886 DI 10.7205/MILMED-D-13-00031 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UB UT WOS:000340805400010 PM 23929049 ER PT J AU Marble, S AF Marble, Sanders TI Origins of the Physical Profile SO MILITARY MEDICINE LA English DT Article AB This article examines how the U.S. Army came to adopt the physical profile. In 1945, the Army adopted the physical profile system that has, with some changes, survived to this day. Although the profile system does not always work smoothly, it replaced a system that was failing completely to deliver physically fit men to combat units. The World War II problems were the outgrowth of two World War I systems that had been adopted to speed mobilization by (1) accepting physically substandard men and (2) matching men to a noncombat job by their skills. By simply identifying a soldier as "General Service" or "Limited Service" it did not provide enough information about his limitations. In addition, the Army used an intelligence test to grade manpower, but because it lacked information on a man's physical abilities/limitations, that data were misused to allot manpower. These policies interacted, with a societal disdain for the "handicapped" and "substandard" and made it hard to use Limited Service men. Adding detail to the information on physical abilities was the Army's solution. C1 US Army, Off Med Hist, HQ MEDCOM, MCMH HO, Ft Sam Houston, TX 78234 USA. RP Marble, S (reprint author), US Army, Off Med Hist, HQ MEDCOM, MCMH HO, Ft Sam Houston, TX 78234 USA. NR 35 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2013 VL 178 IS 8 BP 887 EP 892 DI 10.7205/MILMED-D-13-00039 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UB UT WOS:000340805400011 PM 23929050 ER PT J AU Leamer, NK Clemmons, NS Jordan, NN Pacha, LA AF Leamer, Nicole K. Clemmons, Nakia S. Jordan, Nikki N. Pacha, Laura A. TI Update: Community-Acquired Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection Surveillance Among Active Duty Military Personnel at Fort Benning GA, 2008-2010 SO MILITARY MEDICINE LA English DT Article ID RISK-FACTORS; CLONE; USA300; OUTBREAK; DISEASE AB Background: Increasing numbers of Staphylococcus aureus infections demonstrate antibiotic resistance. Military populations experiencing crowding are at increased risk of community-acquired methicillin-resistant S. aureus (CA-MRSA) infection. High prevalence of CA-MRSA infection among Army personnel was previously documented at Fort Benning, GA from 2002 to 2007. Purpose: To ascertain recent CA-MRSA trends at Fort Berming regarding antibiotic susceptibility, infection rates, and treatment regimens among Army personnel. Methods: Incident CA-MRSA cases among active duty members/trainees from January 2008 to December 2010 were identified using active surveillance and laboratory data. Results: In total, 2,171 infections were identified, representing 5,794 CA-MRSA-related clinic visits. Annual rates decreased from 33 to 27 infections per 1,000 soldiers from 2008 to 2010. Approximately 78% of isolates were from training units. Approximately 4% of infections required hospitalization. Most infections (97%) were treated with antibiotics (36% received antibiotics and wound drainage). Antibiotic susceptibility patterns remained comparable to previous assessments. Conclusion: The observed decline in CA-MRSA rates and associated hospitalizations, coupled with stable antibiotic susceptibility patterns, is encouraging. Passive surveillance using laboratory records proved useful in identifying infection and could enhance detection across training sites. Given the continued high CA-MRSA prevalence among trainees, providers/public health personnel should remain vigilant to bolster prevention, detection, and treatment efforts. C1 [Leamer, Nicole K.; Clemmons, Nakia S.; Jordan, Nikki N.; Pacha, Laura A.] US Army Publ Hlth Command, Dis Epidemiol Program, Aberdeen Proving Ground, MD 21010 USA. [Leamer, Nicole K.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. RP Leamer, NK (reprint author), US Army Publ Hlth Command, Dis Epidemiol Program, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. FU Student Research Participation Program at the U.S. Army Public Health Command administered by the Oak Ridge Institute for Science and Education; U.S. Department of Energy; U.S. Army Public Health Command FX This manuscript is in honor of the late James Patrick, who initiated this surveillance project for the good of Soldiers. We thank Linda Brannan, Paul Pietrusiak, Uzo Chukwuma, Matt Inscore, Tanja Reed, and Dr. Tina Daniels for their assistance, and LTC Michael Ellis and Stephanie Morrison-Rodriguez for their review of the manuscript. This research was supported in part by an appointment to the Student Research Participation Program at the U.S. Army Public Health Command administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Public Health Command. NR 28 TC 7 Z9 11 U1 1 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2013 VL 178 IS 8 BP 914 EP 920 DI 10.7205/MILMED-D-13-00082 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UB UT WOS:000340805400016 PM 23929055 ER PT J AU DeGroot, DW Gallimore, RP Thompson, SM Kenefick, RW AF DeGroot, David W. Gallimore, Richard P. Thompson, Shawn M. Kenefick, Robert W. TI Extremity cooling for heat stress mitigation in military and occupational settings SO JOURNAL OF THERMAL BIOLOGY LA English DT Review DE Core temperature; Exertional heat illness; Active cooling; Heat stress; Hyperthermia ID SKIN BLOOD-FLOW; CORE TEMPERATURE; PHYSIOLOGICAL STRAIN; ILLNESS; WATER; ENVIRONMENT; IMMERSION; EXERCISE; SOLDIERS; HANDS AB Physical work, high ambient temperature and wearing protective clothing can elevate body temperature and cardiovascular strain sufficiently to degrade performance and induce heat-related illnesses. We have recently developed an Arm Immersion Cooling System (AICS) for use in military training environments and this paper will review literature supporting such an approach and provide details regarding its construction. Extremity cooling in cool or cold water can accelerate body (core temperature) cooling from 0.2 to 1.0 degrees C/10 min vs. control conditions, depending on the size/surface area of the extremity immersed. Arm immersion up to the elbow results in greater heat loss than hand- or foot-only immersion and may reduce cardiovascular strain by lowering heart rate by 10-25 beats/min and increase work tolerance time by up to 60%. The findings from studies in this paper support the use of AICS prototypes, which have been incorporated as part of the heat stress mitigation procedures employed in US Army Ranger Training and may have great application for sports and occupational use. Published by Elsevier Ltd. C1 [DeGroot, David W.; Kenefick, Robert W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. [Gallimore, Richard P.] Natick Operat Supporting Natick Soldier Res Dev &, Battelle Mem Inst, Natick, MA 01760 USA. [Thompson, Shawn M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78219 USA. RP DeGroot, DW (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen 21010, MD, Scotland. EM david.w.degrootmil@mail.mil RI DeGroot, David/E-2322-2015 NR 33 TC 12 Z9 12 U1 1 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 2013 VL 38 IS 6 BP 305 EP 310 DI 10.1016/j.jtherbio.2013.03.010 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA 174KC UT WOS:000321153100004 ER PT J AU Cosman, F Ruffing, J Zion, M Uhorchak, J Ralston, S Tendy, S McGuigan, FEA Lindsay, R Nieves, J AF Cosman, Felicia Ruffing, Jamie Zion, Marsha Uhorchak, John Ralston, Stuart Tendy, Susan McGuigan, Fiona E. A. Lindsay, Robert Nieves, Jeri TI Determinants of stress fracture risk in United States Military Academy cadets SO BONE LA English DT Article DE Stress fractures; Insufficiency fractures; Military; Department of Defense; Athlete ID FEMALE NAVY RECRUITS; BONE-DENSITY; QUANTITATIVE ULTRASOUND; CALCIUM INTAKE; ARMY RECRUITS; INJURY RATES; YOUNG MEN; WOMEN; GENDER; SUSCEPTIBILITY AB Background: Prior studies have identified some risk factors for stress fracture in athletes and military recruits. Objective: To determine whether historical factors, physical measures, biochemical variables of skeletal metabolism, genetic factors, bone density (BMD) and bone size could predict risk of stress fracture over 4 years in physically fit cadets at the US Military Academy (USMA). Methods: Baseline surveys, assessments of height, weight, scores on the Army Physical Fitness Test, and peripheral BMD were obtained in all cadets (755 men, 136 women), and central BMD in a subset. Blood samples were analyzed for variables of calcium homeostasis, bone turnover, and selected hormones and genetic factors. Stress fractures were adjudicated by review of orthopedic notes and imaging reports. Results: 5.7% of male and 19.1% of female cadets had at least 1 stress fracture (58% metatarsal and 29% tibial), most within 3 months of entry to USMA. In males, risk of stress fracture was higher in those who exercised <7 h per week during the prior year (RR 2.31; CI 1.29,4.12), and in those with smaller tibial cortical area (RR 1.12; CI 1.03,1.23), lower tibial bone mineral content (RR 1.11; CI 1.03,1.20) and smaller femoral neck diameter (RR 1.35, CI 1.01, 1.81). In women, higher stress fracture risk was seen in those with shorter time since menarche (RR 1.44 per year; Cl 1.19, 1.73) and smaller femoral neck diameter (RR 1.16; Cl 1.01, 1.33.). Conclusion: Although prior physical training in men, length of prior estrogen exposure in women and leg bone dimensions in both genders played a role, the maximum variance explained by all of these factors was below 10%. We conclude these factors play a minor role in the development of stress fractures in physically fit USMA cadets. (C) 2013 Elsevier Inc. All rights reserved. C1 [Cosman, Felicia; Ruffing, Jamie; Zion, Marsha; Lindsay, Robert; Nieves, Jeri] Helen Hayes Hosp, W Haverstraw, NY 10993 USA. [Cosman, Felicia; Lindsay, Robert] Columbia Univ, Dept Med, New York, NY 10032 USA. [Uhorchak, John; Tendy, Susan] US Mil Acad, West Point, NY 10996 USA. [Ralston, Stuart] Univ Edinburgh, Mol Med Ctr, Edinburgh EH8 9YL, Midlothian, Scotland. [Nieves, Jeri] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA. [McGuigan, Fiona E. A.] Lund Univ, Dept Clin Sci Malmo, Clin & Mol Osteoporosis Res Unit, Malmo, Sweden. RP Cosman, F (reprint author), Helen Hayes Hosp, Reg Bone Ctr, W Haverstraw, NY 10993 USA. EM cosmanf@helenhayeshosp.org FU U.S. Army Medical Research and Materiel Command [DAMD17-98-1-8539] FX This study was funded by a grant from the U.S. Army Medical Research and Materiel Command, award number DAMD17-98-1-8539. NR 65 TC 20 Z9 23 U1 2 U2 28 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 J9 BONE JI Bone PD AUG PY 2013 VL 55 IS 2 BP 359 EP 366 DI 10.1016/j.bone.2013.04.011 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 171AK UT WOS:000320896600013 PM 23624291 ER PT J AU Justusson, B Pankow, M Heinrich, C Rudolph, M Waas, AM AF Justusson, B. Pankow, M. Heinrich, C. Rudolph, M. Waas, A. M. TI Use of a shock tube to determine the bi-axial yield of an aluminum alloy under high rates SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Shock; Mechanical properties; Strain rate; Multiaxial response ID HOPKINSON PRESSURE BAR; AL-MN ALLOY; STRAIN RATES; PLATES; SHEET AB This paper presents a method for extracting the bi-axial rate dependent mechanical properties of thin homogenous materials, using a shock tube, demonstrated here using an aluminum alloy sheet. Rate dependence determination techniques such as Split Hopkinson Pressure Bar (SHPB) have long been used for determining uniaxial properties. Recent advances have led to modification of the SHPB to include a bulge cell to develop a so called "dynamic bulge test". Due to the relative fixed nature of the SHPB, it is difficult to obtain lower strain rate response without significantly modifying the test fixture. Using shock wave loading, and a flat, circular thin plate specimen, a state of biaxial tensile stress is created at the center of the crown during intermediate to high rates of loading. An inverse modeling technique in conjunction with a finite element (FE) simulation technique is used to determine the rate dependent constitutive properties of the plate material. This work demonstrates the applicability of the shock loading method for extracting rate dependent properties of materials available in thin sheet form by using commercial grade aluminum. A finite element model of the shock response is used to determine the strain rate dependent mechanical properties using an optimization algorithm and an inverse modeling method. The results were found to be in agreement with previous literature and good correlation between the model and experimental results are presented here. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Justusson, B.; Pankow, M.; Heinrich, C.; Rudolph, M.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Pankow, M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA. EM dcw@umich.edu FU Army Research Laboratories at the Aberdeen Proving Grounds, MD FX The authors would like to thank the Army Research Laboratories at the Aberdeen Proving Grounds, MD for their continued financial support. The authors also gratefully acknowledge the encouragement and support of Dr. CF Yen. NR 23 TC 2 Z9 2 U1 0 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 2013 VL 58 BP 55 EP 65 DI 10.1016/j.ijimpeng.2013.01.012 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 139LB UT WOS:000318583100005 ER PT J AU Jia, ZZ Sun, J Oh, SR Dobbs, H King, J AF Jia, Zhenzhong Sun, Jing Oh, So-Ryeok Dobbs, Herb King, Joel TI Control of the dual mode operation of generator/motor in SOFC/GT-based APU for extended dynamic capabilities SO JOURNAL OF POWER SOURCES LA English DT Article DE Solid oxide fuel cell (SOFC); Gas turbine (GT); Auxiliary power unit (APU); Load following; Generator/motor; Dual mode operation ID OXIDE FUEL-CELL; TURBINE HYBRID SYSTEMS AB The integrated solid oxide fuel cell (SOFC)/gas turbine (GT) system is an appealing power generation solution for mobile applications from energy conversion efficiency point of view. The relatively poor dynamic capabilities of the SOFC/GT system, which are often the results of system characteristics and SOFC operation safety considerations, limit their widespread applications and must be enhanced to meet safe, efficient and fast load following requirements. To this end, the SOFC/GT system can be augmented by an energy storage unit (e.g., battery) and a dual operating generator/motor (G/M). This paper focuses on investigating the G/M dual mode operation and its implications on system transient performance and battery requirements. Active shaft load control is achieved to manage the load transients through: (a) pre-conditioning of the generator power for load step-up transients; (b) absorbing the excessive power by motoring operation for load step-down transients. By taking full advantage of the bi-directional operation of G/M, we show that better trade-offs between power tracking and thermal management can be achieved, power and energy requirements for the energy storage (battery) can be reduced, and overall system performance can be enhanced. (C) 2013 Elsevier B.V. All rights reserved. C1 [Jia, Zhenzhong; Sun, Jing; Oh, So-Ryeok] Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA. [Dobbs, Herb; King, Joel] USA, TARDEC, Nonprimary Power Syst Team, Warren, MI 48397 USA. RP Jia, ZZ (reprint author), Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA. EM zhenzjia@umich.edu; jingsun@umich.edu; srohum@umich.edu FU Automotive Research Center (US Army TARDEC); Naval Engineering Education Center (US Navy) FX The authors would like to acknowledge Automotive Research Center (US Army TARDEC) and Naval Engineering Education Center (US Navy) for the support of this research. NR 14 TC 11 Z9 11 U1 2 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD AUG 1 PY 2013 VL 235 BP 172 EP 180 DI 10.1016/j.jpowsour.2013.01.170 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 134HF UT WOS:000318200300024 ER PT J AU Thomassen, HA Fuller, T Asefi-Najafabady, S Shiplacoff, JAG Mulembakani, PM Blumberg, S Johnston, SC Kisalu, NK Kinkela, TL Fair, JN Wolfe, ND Shongo, RL LeBreton, M Meyer, H Wright, LL Muyembe, JJ Buermann, W Okitolonda, E Hensley, LE Lloyd-Smith, JO Smith, TB Rimoin, AW AF Thomassen, Henri A. Fuller, Trevon Asefi-Najafabady, Salvi Shiplacoff, Julia A. G. Mulembakani, Prime M. Blumberg, Seth Johnston, Sara C. Kisalu, Neville K. Kinkela, Timothee L. Fair, Joseph N. Wolfe, Nathan D. Shongo, Robert L. LeBreton, Matthew Meyer, Hermann Wright, Linda L. Muyembe, Jean-Jacques Buermann, Wolfgang Okitolonda, Emile Hensley, Lisa E. Lloyd-Smith, James O. Smith, Thomas B. Rimoin, Anne W. TI Pathogen-Host Associations and Predicted Range Shifts of Human Monkeypox in Response to Climate Change in Central Africa SO PLOS ONE LA English DT Article ID SPECIES DISTRIBUTION MODELS; INFECTIOUS-DISEASES; ECOLOGICAL NICHE; UNITED-STATES; PUBLIC-HEALTH; RISK-FACTORS; SAMPLE-SIZE; MODIS DATA; VIRUS; DISTRIBUTIONS AB Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future climate conditions, we used ecological niche modeling techniques in conjunction with climate and remote-sensing variables. We first created spatially explicit probability distributions of its candidate reservoir species in Africa's Congo Basin. Reservoir species distributions were subsequently used to model current and projected future distributions of human monkeypox (MPX). Results indicate that forest clearing and climate are significant driving factors of the transmission of MPX from wildlife to humans under current climate conditions. Models under contemporary climate conditions performed well, as indicated by high values for the area under the receiver operator curve (AUC), and tests on spatially randomly and non-randomly omitted test data. Future projections were made on IPCC 4th Assessment climate change scenarios for 2050 and 2080, ranging from more conservative to more aggressive, and representing the potential variation within which range shifts can be expected to occur. Future projections showed range shifts into regions where MPX has not been recorded previously. Increased suitability for MPX was predicted in eastern Democratic Republic of Congo. Models developed here are useful for identifying areas where environmental conditions may become more suitable for human MPX; targeting candidate reservoir species for future screening efforts; and prioritizing regions for future MPX surveillance efforts. C1 [Thomassen, Henri A.; Fuller, Trevon; Shiplacoff, Julia A. G.; Buermann, Wolfgang; Smith, Thomas B.] Univ Calif Los Angeles, Ctr Trop Res, Los Angeles, CA USA. [Thomassen, Henri A.] Univ Tubingen, Dept Comparat Zool, Tubingen, Germany. [Asefi-Najafabady, Salvi] Arizona State Univ, Sch Life Sci, Tempe, AZ USA. [Asefi-Najafabady, Salvi] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA USA. [Mulembakani, Prime M.; Kinkela, Timothee L.; Okitolonda, Emile] Kinshasa Sch Publ Hlth, Kinshasa, Zaire. [Blumberg, Seth; Lloyd-Smith, James O.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Blumberg, Seth; Lloyd-Smith, James O.; Smith, Thomas B.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA. [Johnston, Sara C.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Kisalu, Neville K.; Rimoin, Anne W.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90024 USA. [Fair, Joseph N.; Wolfe, Nathan D.; LeBreton, Matthew] Global Viral Forecasting, San Francisco, CA USA. [Wolfe, Nathan D.] Stanford Univ, Program Human Biol, Stanford, CA 94305 USA. [Shongo, Robert L.] Minist Hlth, Kinshasa, Zaire. [Meyer, Hermann] Bundeswehr Inst Microbiol, Munich, Germany. [Wright, Linda L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA. [Muyembe, Jean-Jacques] Natl Inst Biomed Res, Kinshasa, Zaire. [Buermann, Wolfgang] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA. [Hensley, Lisa E.] Med Countermeasures Initiat, Silver Spring, MD USA. [Rimoin, Anne W.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. RP Rimoin, AW (reprint author), Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90024 USA. EM arimoin@ucla.edu RI Lloyd-Smith, James/K-4080-2012 OI Lloyd-Smith, James/0000-0001-7941-502X FU Faucett Family Foundation; National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America; National Science Foundation-National Institutes of Health Ecology of Infectious Diseases Program [EF-0430146]; RAPIDD program of the Science & Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health; National Institute of Allergy and Infectious Diseases [EID-1R01AI074059-01]; NIH [DP1-OD00370]; Google.org; Skoll Foundation; Henry M. Jackson Foundation for the Advancement of Military Medicine; US Armed Forces Health Surveillance Center Division of GEIS Operations; United States Agency for International Development (USAID) Emerging Pandemic Threats Program; PREDICT project [GHN-A-OO-09-00010-00]; Department of Homeland Security/National Biodefense Analysis and Countermeasures Center [HSQDC-05-X-000-35/P400006] FX This work was made possible by the support of the Faucett Family Foundation. The authors thank the DRC Ministry of Health and local health workers who were responsible for specimen collection and case investigation. Additional support for this study was provided by the National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America, by the joint National Science Foundation-National Institutes of Health Ecology of Infectious Diseases Program (grant number EF-0430146), and the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, by the Fogarty International Center, National Institutes of Health, and by the National Institute of Allergy and Infectious Diseases (grant number EID-1R01AI074059-01). NDW is supported by the NIH Director's Pioneer Award (DP1-OD00370). Global Viral Forecasting is supported by Google.org, the Skoll Foundation, the Henry M. Jackson Foundation for the Advancement of Military Medicine, the US Armed Forces Health Surveillance Center Division of GEIS Operations, and the United States Agency for International Development (USAID) Emerging Pandemic Threats Program, PREDICT project, under the terms of Cooperative Agreement Number GHN-A-OO-09-00010-00. This study is made possible by the generous support of the American people through the United States Agency for International Development (USAID). The contents are the responsibility of the authors and do not necessarily reflect the views of USAID or the United States Government. Further support came from the Department of Homeland Security/National Biodefense Analysis and Countermeasures Center Project #HSQDC-05-X-000-35/P400006 (RSCB-09-00343). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 90 TC 2 Z9 2 U1 1 U2 31 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 31 PY 2013 VL 8 IS 7 AR e66071 DI 10.1371/journal.pone.0066071 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 194LB UT WOS:000322633700002 PM 23935820 ER PT J AU Valcour, VG Ananworanich, J Agsalda, M Sailasuta, N Chalermchai, T Schuetz, A Shikuma, C Liang, CY Jirajariyavej, S Sithinamsuwan, P Tipsuk, S Clifford, DB Paul, R Fletcher, JLK Marovich, MA Slike, BM DeGruttola, V Shiramizu, B AF Valcour, Victor G. Ananworanich, Jintanat Agsalda, Melissa Sailasuta, Napapon Chalermchai, Thep Schuetz, Alexandra Shikuma, Cecilia Liang, Chin-Yuan Jirajariyavej, Supunee Sithinamsuwan, Pasiri Tipsuk, Somporn Clifford, David B. Paul, Robert Fletcher, James L. K. Marovich, Mary A. Slike, Bonnie M. DeGruttola, Victor Shiramizu, Bruce CA SEARCH 011 Protocol Team TI HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naive Patients SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; NEUROCOGNITIVE DISORDERS; CIRCULATING MONOCYTES; DISEASE PROGRESSION; DEMENTIA; INFECTION; AIDS; SPECTROSCOPY; PERSISTENCE AB Objectives: Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14(+) enriched monocytes predicted cognitive impairment and brain injury. Methods: We enrolled 61 cART-naive HIV-infected Thais in a prospective study and measured HIV DNA in CD14+ enriched monocyte samples in a blinded fashion. We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy (MRS) to measure markers of brain injury. Immune activation was measured via cytokines in cerebrospinal fluid (CSF). Results: The mean (SD) age was 35 (6.9) years, CD4 T-lymphocyte count was 236 (139) and log(10) plasma HIV RNA was 4.8 (0.73). Twenty-eight of 61 met HAND criteria. The log(10) CD14(+) HIV DNA was associated with HAND in unadjusted and adjusted models (p=0.001). There was a 14.5 increased odds ratio for HAND per 1 log-value of HIV DNA (10-fold increase in copy number). Plasma CD14(+) HIV DNA was associated with plasma and CSF neopterin (p = 0.023) and with MRS markers of neuronal injury (lower N-acetyl aspartate) and glial dysfunction (higher myoinositol) in multiple brain regions. Interpretation: Reservoir burden of HIV DNA in monocyte-enriched (CD14(+)) peripheral blood cells increases risk for HAND in treatment-naive HIV+ subjects and is directly associated with CSF immune activation and both brain injury and glial dysfunction by MRS. C1 [Valcour, Victor G.] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Valcour, Victor G.] Univ Calif San Francisco, Dept Med, Div Geriatr Med, San Francisco, CA USA. [Ananworanich, Jintanat; Chalermchai, Thep; Tipsuk, Somporn; Fletcher, James L. K.] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. [Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat; Agsalda, Melissa; Shikuma, Cecilia; Liang, Chin-Yuan; Shiramizu, Bruce] Univ Hawaii, Hawaii Ctr AIDS, Honolulu, HI 96822 USA. [Sailasuta, Napapon] Huntington Med Res Inst, Pasadena, CA USA. [Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Jirajariyavej, Supunee] Taksin Hosp, Bangkok, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Dept Med, Div Neurol, Bangkok, Thailand. [Clifford, David B.] Washington Univ, Dept Neurol, St Louis, MO USA. [Paul, Robert] Univ Missouri, Dept Psychol, St Louis, MO 63121 USA. [Marovich, Mary A.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. [Marovich, Mary A.; Slike, Bonnie M.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Slike, Bonnie M.] Queen Savang Vadhana Mem Hosp, Si Racha, Thailand. [DeGruttola, Victor] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. RP Valcour, VG (reprint author), Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. EM vvalcour@memory.ucsf.edu FU NINDS/NIH [R01-NS053359, R01-NS061696, R01-NS053345]; NIMH/NIH [R21-MH072388]; NIMHD/NIH [MD007584]; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), through UCSF-CTSI [UL1 TR000004]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [W81XWH-11-2-0174]; U.S. Department of Defense [W81XWH-11-2-0174] FX This work was supported by R01-NS053359 (NINDS/NIH - SRK), R01-NS061696 (NINDS/NIH - VV), R21-MH072388 (NIMH/NIH - VV), R01-NS053345 (NINDS/NIH - BS), and MD007584 (NIMHD/NIH - BS, CS). Added statistical assistance was supported by the National Center for Advancing Translational Sciences, National Institutes of Health (NIH), through UCSF-CTSI Grant Number UL1 TR000004. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. This work was supported in part by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, and the U.S. Department of Defense. The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 28 Z9 28 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 31 PY 2013 VL 8 IS 7 AR e70164 DI 10.1371/journal.pone.0070164 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 194LB UT WOS:000322633700058 PM 23936155 ER PT J AU Walsh, LA Hughes, G Lin, J Hurley, PK O'Regan, TP Cockayne, E Woicik, JC AF Walsh, Lee A. Hughes, Greg Lin, Jun Hurley, Paul K. O'Regan, Terrance P. Cockayne, Eric Woicik, Joseph C. TI Hard x-ray photoelectron spectroscopy and electrical characterization study of the surface potential in metal/Al2O3/GaAs(100) metal-oxide-semiconductor structures SO PHYSICAL REVIEW B LA English DT Article ID SYNCHROTRON-RADIATION; ELECTRONIC-PROPERTIES; INTERFACES; PHOTOEMISSION; GAAS; PHOTOVOLTAGE; CS/GAAS(110) AB Hard x-ray photoelectron spectroscopy (HAXPES) has been used to study metal-oxide-semiconductor (MOS) structures fabricated with both high (Ni) and low (Al) work-function metals on 8-nm thick Al2O3 dielectric layers, deposited on sulfur passivated n- and p-doped GaAs substrates. A binding energy difference of 0.6 eV was measured between the GaAs core levels of the n- and p-doped substrates in the absence of gate metals, indicating different Fermi level positions in the band gap. Subsequent photoemission measurements made on the MOS structures with the different work-function metals displayed very limited change in the GaAs core level binding energies, indicating that the movement of the Fermi level at the Al2O3/GaAs interface is restricted. Using a combination of HAXPES measurements and theoretical calculations, the Fermi level positions in the band gap have been determined to be in the range of 0.4-0.75 eV and 0.8-1.11 eV above the valence band maximum for p- and n-type GaAs, respectively. Analysis of capacitance voltage (C-V) measurements on identically prepared samples yield very similar Fermi level positions at zero applied gate bias. The C-V analysis also indicates a higher interface defect density (D-it) in the upper half of the GaAs bandgap. C1 [Walsh, Lee A.; Hughes, Greg] Dublin City Univ, Dept Phys Sci, Dublin 9, Ireland. [Lin, Jun; Hurley, Paul K.] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. [O'Regan, Terrance P.] US Army Res Lab, Adelphi, MD 20783 USA. [Cockayne, Eric; Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA. RP Walsh, LA (reprint author), Dublin City Univ, Dept Phys Sci, Dublin 9, Ireland. EM lee.walsh36@mail.dcu.ie OI Hughes, Greg/0000-0003-1310-8961; Hughes, Gregory/0000-0002-1358-9032 FU SFI [SFI/09/IN.1/I2633]; US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX The authors from Dublin City University and the Tyndall National Institute acknowledge the financial support of SFI under Grant No. SFI/09/IN.1/I2633. The central fabrication facility at Tyndall are acknowledged for the fabrication of the experimental samples used in this work. Ian Povey from Tyndall is acknowledged for the ALD growth of the Al2O3 layers. Abdul K. Rumaiz is acknowledged for the fitting of the theoretical DOS used in this work. Access to the X24A HAXPES beamline at Brookhaven National Laboratory was obtained through a General User Proposal. Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. NR 30 TC 5 Z9 5 U1 5 U2 44 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL 30 PY 2013 VL 88 IS 4 AR 045322 DI 10.1103/PhysRevB.88.045322 PG 7 WC Physics, Condensed Matter SC Physics GA 193UV UT WOS:000322587900002 ER PT J AU Olson, MA Lee, MS AF Olson, Mark A. Lee, Michael S. TI Application of replica exchange umbrella sampling to protein structure refinement of nontemplate models SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE Langevin dynamics; model decoys; Hamiltonian replica exchange; structure identification; conformational sampling ID MOLECULAR-DYNAMICS SIMULATIONS; GUIDED LANGEVIN DYNAMICS; FREE-ENERGY LANDSCAPE; STATISTICAL POTENTIALS; HOMOLOGY MODELS; CONFORMATIONS; PREDICTION; FORCE; BACKBONE; SOLVENT AB We provide an assessment of a computational strategy for protein structure refinement that combines self-guided Langevin dynamics with umbrella-potential biasing replica exchange using the radius of gyration as a coordinate (Rg-ReX). Eight structurally nonredundant proteins and their decoys were examined by sampling conformational space at room temperature using the CHARMM22/GBMV2 force field to generate the ensemble of structures. Two atomic statistical potentials (RWplus and DFIRE) were analyzed for structure identification and compared to the simulation force-field potential. The results show that, while the Rg-ReX simulations were able to sample conformational basins that were more structurally similar to the X-ray crystallographic structures than the starting first-order ranked decoys, the potentials failed to detect these basins from refinement. Of the three potential functions, RWplus yielded the highest accuracy for recognition of structures that refined to an average of nearly 20% increase in native contacts relative to the starting decoys. The overall performance of Rg-ReX is compared to an earlier study of applying temperature-based replica exchange to refine the same decoy sets and highlights the general challenge of achieving consistently the sampling and detection threshold of 70% fraction of native contacts. (c) 2013 Wiley Periodicals, Inc. C1 [Olson, Mark A.; Lee, Michael S.] USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. [Lee, Michael S.] US Army, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Olson, MA (reprint author), USAMRIID, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. EM molson@compbiophys.org FU US Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T, CBCALL12-LS6-2-003] FX Contract grant sponsor: US Department of Defense Threat Reduction Agency; Contract grant numbers: TMTI0004_09_BH_T and CBCALL12-LS6-2-003 NR 30 TC 2 Z9 2 U1 2 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD JUL 30 PY 2013 VL 34 IS 20 BP 1785 EP 1793 DI 10.1002/jcc.23325 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA 171MY UT WOS:000320934700007 PM 23703032 ER PT J AU Wang, D Donetsky, D Kipshidze, G Lin, YX Shterengas, L Belenky, G Sarney, W Svensson, S AF Wang, Ding Donetsky, Dmitry Kipshidze, Gela Lin, Youxi Shterengas, Leon Belenky, Gregory Sarney, Wendy Svensson, Stefan TI Metamorphic InAsSb-based barrier photodetectors for the long wave infrared region SO APPLIED PHYSICS LETTERS LA English DT Article AB InAs0.6Sb0.4/Al0.75In0.25Sb-based barrier photodetectors were grown metamorphically on compositionally graded Ga1-xInxSb buffer layers and GaSb substrates by molecular beam epitaxy. At the wavelength of 8 mu m and T = 150 K, devices with 1-mu m thick absorbers demonstrated an external quantum efficiency of 18% under a bias voltage of 0.45 V. (C) 2013 AIP Publishing LLC. C1 [Wang, Ding; Donetsky, Dmitry; Kipshidze, Gela; Lin, Youxi; Shterengas, Leon; Belenky, Gregory] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. [Sarney, Wendy; Svensson, Stefan] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, D (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. EM gregory.belenky@stonybrook.edu OI LIN, YOUXI/0000-0002-9092-2302 FU US Army Research Office [W911NF1110109, W911NF1220057]; US National Science Foundation [DMR1160843] FX The work was supported by US Army Research Office through grants (Nos. W911NF1110109 and W911NF1220057) and by US National Science Foundation through grant (No. DMR1160843). NR 11 TC 16 Z9 16 U1 3 U2 33 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 29 PY 2013 VL 103 IS 5 AR 051120 DI 10.1063/1.4817823 PG 3 WC Physics, Applied SC Physics GA 195SD UT WOS:000322723000020 ER PT J AU Chang, YC Wang, C Yin, SZ Hoffman, RC Mott, AG AF Chang, Yun-Ching Wang, Chao Yin, Shizhuo Hoffman, Robert C. Mott, Andrew G. TI Kovacs effect enhanced broadband large field of view electro-optic modulators in nanodisordered KTN crystals SO OPTICS EXPRESS LA English DT Article ID TANTALATE-NIOBATE CRYSTALS; SCALE-FREE OPTICS AB The unique physical effect-Kovacs effect is explored to enhance the performance of EO modulators by employing the non-thermal equilibrium state nanodisordered KTN crystals created by super-cooling process, which can have a significant 3.5 fold increase in quadratic electro-optic coefficient. This enables to reduce the switching half wave voltage (almost by half) so that a broadband (similar to GHz range) and large field of view (+/-30 deg) electro-optic modulator can be realized with much lowered driving power, which can be very useful for a variety of applications: laser Q-switches, laser pulse shaping, high speed optical shutters and modulating retro reflectors. (C) 2013 Optical Society of America C1 [Chang, Yun-Ching; Wang, Chao; Yin, Shizhuo] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Hoffman, Robert C.; Mott, Andrew G.] US Army Res Lab, Adelphi, MD 20783 USA. RP Yin, SZ (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU Army Research Laboratory [W911NF-09-2-0016] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0016. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. NR 13 TC 21 Z9 21 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 29 PY 2013 VL 21 IS 15 BP 17760 EP 17768 DI 10.1364/OE.21.017760 PG 9 WC Optics SC Optics GA 190UJ UT WOS:000322366300038 PM 23938649 ER PT J AU Liu, M Ma, CR Collins, G Liu, J Chen, CL Alemayehu, AD Subramanyam, G Ding, Y Chen, JH Dai, C Lin, Y Cole, MW AF Liu, Ming Ma, Chunrui Collins, Gregory Liu, Jian Chen, Chonglin Alemayehu, Andy D. Subramanyam, Guru Ding, Ying Chen, Jianghua Dai, Chao Lin, Yuan Cole, Melanie W. TI Ferroelectric BaTiO3/SrTiO3 multilayered thin films for room-temperature tunable microwave elements SO NANOSCALE RESEARCH LETTERS LA English DT Article DE BaTiO3//SrTiO3; Multilayer; Ferroelectric thin films; Epitaxial behavior; Microwave dielectric properties ID PULSED-LASER DEPOSITION; HIGH-DIELECTRIC-TUNABILITY; DNA-BASED POLYMERS; EPITAXIAL-GROWTH; SUPERLATTICES; CONSTANT AB Ferroelectric BaTiO3/SrTiO3 with optimized c-axis-oriented multilayered thin films were epitaxially fabricated on (001) MgO substrates. The microstructural studies indicate that the in-plane interface relationships between the films as well as the substrate are determined to be (001)(SrTiO3)//(001)(BaTiO3)//(001)(MgO) and [100](SrTiO3)//[100](BaTiO3)//[100](MgO). The microwave (5 to 18 GHz) dielectric measurements reveal that the multilayered thin films have excellent dielectric properties with large dielectric constant, low dielectric loss, and high dielectric tunability, which suggests that the as-grown ferroelectric multilayered thin films can be developed for room-temperature tunable microwave elements and related device applications. C1 [Liu, Ming] Xi An Jiao Tong Univ, Elect Mat Res Lab, Key Lab, Minist Educ, Xian 710049, Peoples R China. [Liu, Ming] Xi An Jiao Tong Univ, Int Ctr Dielect Res, Xian 710049, Peoples R China. [Liu, Ming; Ma, Chunrui; Collins, Gregory; Liu, Jian; Chen, Chonglin] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Alemayehu, Andy D.; Subramanyam, Guru] Univ Dayton, Dept Elect & Comp Engn, Dayton, OH 45469 USA. [Ding, Ying; Chen, Jianghua] Hunan Univ, Ctr High Resolut Electron Microscopy, Changsha 410082, Hunan, Peoples R China. [Dai, Chao; Lin, Yuan] Univ Elect Sci & Technol China, State Key Lab Elect Thin Films & Integrated Devic, Chengdu 610054, Sichuan, Peoples R China. [Cole, Melanie W.] US Army Res Lab, Rodman Mat Res Directorate, Aberdeen, MD 21005 USA. RP Chen, CL (reprint author), Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. EM cl.chen@utsa.edu RI Liu, Ming/F-5084-2010; lin, yuan/B-9955-2013 FU National Science Foundation [NSF-NIRT-0709293]; Natural Science Foundation of China [11028409]; China Scholarship Council FX This research was partially supported by the National Science Foundation under NSF-NIRT-0709293 and the Natural Science Foundation of China under 11028409. Also, Dr. Ming Liu and Dr. Chunrui Ma would like to acknowledge the support from the 'China Scholarship Council' for their PhD researches at UTSA. NR 38 TC 8 Z9 9 U1 3 U2 54 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1556-276X J9 NANOSCALE RES LETT JI Nanoscale Res. Lett. PD JUL 29 PY 2013 VL 8 AR 338 DI 10.1186/1556-276X-8-338 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 205DA UT WOS:000323420300001 PM 23895295 ER PT J AU Ahmed, S Ratanapo, S Kittanamongkolchai, W Cheungpasitporn, W Suksaranjit, P Chongnarungsin, D AF Ahmed, Saeed Ratanapo, Supawat Kittanamongkolchai, Wonngarm Cheungpasitporn, Wisit Suksaranjit, Promporn Chongnarungsin, Daych TI Vitamin D deficiency and cardiovascular disease SO SWISS MEDICAL WEEKLY LA English DT Letter ID RISK; METAANALYSIS; OUTCOMES; HEALTH C1 [Ahmed, Saeed; Ratanapo, Supawat; Kittanamongkolchai, Wonngarm; Cheungpasitporn, Wisit; Suksaranjit, Promporn; Chongnarungsin, Daych] Bassett Med Ctr, Dept Med, Cooperstown, NY USA. RP Cheungpasitporn, W (reprint author), USA, Dept Med, Bassett Med Ctr, Cooperstown, NY 13326 USA. EM wisit.cheungpasitporn@bassett.org OI Ahmed, Saeed/0000-0003-3371-9110 NR 8 TC 0 Z9 0 U1 0 U2 6 PU E M H SWISS MEDICAL PUBLISHERS LTD PI MUTTENZ PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND SN 1424-7860 J9 SWISS MED WKLY JI Swiss Med. Wkly. PD JUL 29 PY 2013 VL 143 AR w13821 DI 10.4414/smw.2013.13821 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 202FU UT WOS:000323200100004 PM 23897046 ER PT J AU Lee, MS Olson, MA AF Lee, Michael S. Olson, Mark A. TI Comparison of volume and surface area nonpolar solvation free energy terms for implicit solvent simulations SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; GUIDED LANGEVIN DYNAMICS; GENERALIZED BORN; REPLICA-EXCHANGE; PROTEIN STRUCTURES; MODELS; PEPTIDE; CONFORMATIONS; LANDSCAPE AB Implicit solvent models for molecular dynamics simulations are often composed of polar and nonpolar terms. Typically, the nonpolar solvation free energy is approximated by the solvent-accessible-surface area times a constant factor. More sophisticated approaches incorporate an estimate of the attractive dispersion forces of the solvent and/or a solvent-accessible volume cavitation term. In this work, we confirm that a single volume-based nonpolar term most closely fits the dispersion and cavitation forces obtained from benchmark explicit solvent simulations of fixed protein conformations. Next, we incorporated the volume term into molecular dynamics simulations and find the term is not universally suitable for folding up small proteins. We surmise that while mean-field cavitation terms such as volume and SASA often tilt the energy landscape towards native-like folds, they also may sporadically introduce bottlenecks into the folding pathway that hinder the progression towards the native state. C1 [Lee, Michael S.] US Army Res Lab, Computat Sci Div, Aberdeen, MD 21005 USA. [Lee, Michael S.; Olson, Mark A.] US Army Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Frederick, MD 21702 USA. RP Lee, MS (reprint author), US Army Res Lab, Computat Sci Div, Aberdeen, MD 21005 USA. EM michael.s.lee131.civ@mail.mil FU Defense Threat Reduction Agency Grant [TMTI0004_09_BH_T, CBCALL12-LS6-2-0036] FX M.A.O. acknowledges funding from Defense Threat Reduction Agency Grant (Grant Nos. TMTI0004_09_BH_T and CBCALL12-LS6-2-0036). Computational time was provided by the U.S. Army Research Laboratory DoD Super-computing Resource Center. NR 33 TC 6 Z9 6 U1 4 U2 28 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUL 28 PY 2013 VL 139 IS 4 AR 044119 DI 10.1063/1.4816641 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 198VA UT WOS:000322949300022 PM 23901972 ER PT J AU Salzer, WL Asselin, B Supko, JG Devidas, M Kaiser, NA Plourde, P Winick, NJ Reaman, GH Raetz, E Carroll, WL Hunger, SP AF Salzer, Wanda L. Asselin, Barbara Supko, Jeffrey G. Devidas, Meenakshi Kaiser, Nicole A. Plourde, Paul Winick, Naomi J. Reaman, Gregory H. Raetz, Elizabeth Carroll, William L. Hunger, Stephen P. TI Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: a report from the Children's Oncology Group SO BLOOD LA English DT Article ID ACUTE LYMPHOBLASTIC-LEUKEMIA; ESCHERICHIA-COLI-ASPARAGINASE; ACUTE LYMPHOCYTIC-LEUKEMIA; CANCER-STUDY-GROUP; CEREBROSPINAL-FLUID; E. COLI; INTENSIVE ASPARAGINASE; PEG-ASPARAGINASE; SINGLE-AGENT; PHARMACOKINETICS AB AALL07P2 evaluated whether substitution of Erwinia asparaginase 25 000 IU/m(2) for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) >= 0.10 IU/mL. AALL07P2 enrolled 55 eligible/evaluable patients. NSAA >= 0.1 IU/mL was achieved in 38 of 41 patients (92.7%) with acceptable samples 48 hours and in 38 of 43 patients (88.4%) 72 hours after dosing during course 1. Among samples obtained during all courses, 95.8% (252 of 263) of 48-hour samples and 84.5% (125 of 148) of 72-hour samples had NSAA >= 0.10-IU/mL. Pharmacokinetic parameters were estimated by fitting the serum asparaginase activity-time course for all 6 doses given during course 1 to a 1-compartment open model with first order absorption. Erwinia asparaginase administered with this schedule achieved therapeutic NSAA at both 48 and 72 hours and was well tolerated with no reports of hemorrhage, thrombosis, or death, and few cases of grade 2 to 3 allergic reaction (n = 6), grade 1 to 3 hyperglycemia (n = 6), or grade 1 pancreatitis (n = 1). Following allergy to pegaspargase, Erwinia asparaginase 25 000 IU/m(2) x 6 intramuscularly M/W/F can be substituted for a single dose of pegaspargase. C1 [Salzer, Wanda L.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Asselin, Barbara] Univ Rochester, Sch Med, Dept Pediat, Golisano Childrens Hosp,Med Ctr, Rochester, NY 14642 USA. [Supko, Jeffrey G.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Devidas, Meenakshi] Univ Florida, Dept Biostat, Coll Med, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. [Kaiser, Nicole A.; Hunger, Stephen P.] Childrens Hosp Colorado, Aurora, CO USA. [Plourde, Paul] EUSA Pharma, Langhorne, PA USA. [Winick, Naomi J.] Univ Texas SW Med Ctr Dallas, Div Pediat Hematol Oncol, Dallas, TX 75390 USA. [Reaman, Gregory H.] Childrens Natl Med Ctr, Dept Hematol Oncol, Washington, DC 20010 USA. [Raetz, Elizabeth] NYU, Langone Med Ctr, New York, NY USA. [Carroll, William L.] NYU, Inst Canc, New York, NY USA. [Hunger, Stephen P.] Univ Colorado, Dept Pediat, Sch Med, Aurora, CO USA. [Hunger, Stephen P.] Childrens Hosp Colorado, Aurora, CO USA. RP Salzer, WL (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program, 504 Scott St, Ft Detrick, MD 21702 USA. EM wanda.l.salzer.mil@mail.mil FU National Institutes of Health [CA13539, CA98543] FX This work was supported by grants CA13539 and CA98543 from the National Institutes of Health and a research agreement with Jazz Pharma, Inc (Langhorne, PA), formerly EUSA Pharma, Inc. S. P. H. is the Ergen Family Chair in Pediatric Cancer. NR 50 TC 19 Z9 19 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD JUL 25 PY 2013 VL 122 IS 4 BP 507 EP 514 DI 10.1182/blood-2013-01-480822 PG 8 WC Hematology SC Hematology GA 196RD UT WOS:000322792300011 PM 23741010 ER PT J AU Opsenica, IM Tot, M Gomba, L Nuss, JE Sciotti, RJ Bavari, S Burnett, JC Solaja, BA AF Opsenica, Igor M. Tot, Miklos Gomba, Laura Nuss, Jonathan E. Sciotti, Richard J. Bavari, Sina Burnett, James C. Solaja, Bogdan A. TI 4-Amino-7-chloroquinolines: Probing Ligand Efficiency Provides Botulinum Neurotoxin Serotype A Light Chain Inhibitors with Significant Antiprotozoal Activity SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID CLOSTRIDIUM-BOTULINUM; NEUROTRANSMITTER RELEASE; QUINOLINE ANTIMALARIALS; PLASMODIUM-FALCIPARUM; DEGRADATION; MALARIA; METALLOPROTEASE; CHLOROQUINE; DESIGN; DRUGS AB Structurally simplified analogues of dual antimalarial and botulinum neurotoxin serotype A light chain (BoNT/A LC) inhibitor bis-aminoquinoline (1) were prepared. New compounds were designed to improve ligand efficiency while maintaining or exceeding the inhibitory potency of 1. Three of the new compounds are more active than 1 against both indications. Metabolically, the new inhibitors are relatively stable and nontoxic. 12, 14, and 15 are more potent BoNT/A LC inhibitors than 1. Additionally, 15 has excellent in vitro antimalarial efficacy, with IC90 values ranging from 4.45 to 12.11 nM against five Plasmodium falciparum (Pf) strains: W2, D6, C235, C2A, and C2B. The results indicate that the same level of inhibitory efficacy provided by 1 can be retained/exceeded with less structural complexity. 12, 14, and 15 provide new platforms for the development of more potent dual BoNT/A LC and P.f. inhibitors adhering to generally accepted chemical properties associated with the druggability of synthetic molecules. C1 [Opsenica, Igor M.; Tot, Miklos; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia. [Gomba, Laura; Nuss, Jonathan E.] US Army Med Res Inst Infect Dis, Dept Bacteriol, Frederick, MD 21702 USA. [Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Burnett, James C.] FNLCR Frederick, SAIC Frederick Inc, Computat Drug Dev Grp, Frederick, MD USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia. EM jnuss@amgen.com; sina.bavari@us.army.mil; bumettjames@mail.nih.gov; bsolaja@chem.bg.ac.rs RI Opsenica, Igor/P-5308-2016; OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725 FU Defense Threat Reduction Agency [3.10084_09_RD_B, Y3CM 100505]; NATO [SfP983638]; Ministry of Science and Technological Development of Serbia [172008]; Serbian Academy of Sciences and Arts; National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX This research was supported by: (1) Defense Threat Reduction Agency project 3.10084_09_RD_B (and also Agreement Y3CM 100505 (MRMC and NCI, National Institutes of Health)), (2) NATO's Public Diplomacy Division in the framework of "Science for Peace" project SfP983638, and (3) the Ministry of Science and Technological Development of Serbia (grant no. 172008) and the Serbian Academy of Sciences and Arts. The content of this publication does not necessarily reflect the views or policies of the U.S. Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the U.S. Army. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the U.S. Department of the Army, Department of Defense, or National Institutes of Health. For J.C.B., in accordance with SAIC-Frederick, Inc., contractual requirements, the following statement is required: this project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract no. HHSN261200800001E. SARvisionPLUS v. 3.1 (Altoris, ChemApps, La Jolla, USA) was used as a tool for navigation through vast chemical information and as an aide for the identification of structure property relationships generated during the preparation of the current publication. NR 48 TC 14 Z9 14 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 25 PY 2013 VL 56 IS 14 BP 5860 EP 5871 DI 10.1021/jm4006077 PG 12 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 192RM UT WOS:000322503000018 PM 23815186 ER PT J AU Jackson, AC Beyer, FL Price, SC Rinderspacher, BC Lambeth, RH AF Jackson, Aaron C. Beyer, Frederick L. Price, Samuel C. Rinderspacher, B. Christopher Lambeth, Robert H. TI Role of Metal-Ligand Bond Strength and Phase Separation on the Mechanical Properties of Metallopolymer Films SO MACROMOLECULES LA English DT Article ID INDUCED SUPRAMOLECULAR POLYMERIZATION; PI-PI STACKING; SIDE-CHAIN; POLYMERS; TERPYRIDINE; COMPLEXES; THERMODYNAMICS; COPOLYMERS; ROUTE; BLOCK AB This work studies the properties of poly(n-butyl acrylate) functionalized with 2,6-bis(1'-methylbenzimidazolyl)pyridine ligand and cross-linked with either copper(II), zinc(II), or cobalt(II) metal ions. Because of phase separation between the metal-ligand complex and the polymer matrix, these polymers have a rubbery plateau modulus that is 10 times higher than expected based on the theory of rubber elasticity. Differences in the metal-ligand bond strength influence the mechanical behavior at high temperature and strains. Because of the particularly weak bond strength associated with the copper-ligand bond, the metallopolymer containing copper degrades at a lower temperature and has lower yield strength, ultimate tensile strength, and creep resistance than polymers containing cobalt and zinc. To tune the properties of the polymer further, a polymer is made with both copper and cobalt ions. The hybrid polymer combines the properties of the stiffer cobalt-containing polymer with the more compliant copper-containing polymer. C1 [Jackson, Aaron C.; Beyer, Frederick L.; Price, Samuel C.; Rinderspacher, B. Christopher; Lambeth, Robert H.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lambeth, RH (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM robert.h.lambeth2.civ@mail.mil FU Postgraduate Research Participation Program at the US Army Research Laboratory; US Department of Energy; Army Research Laboratory [ORISE 1120-1120-99] FX The authors would like to thank Jonathan Oyler and Kathleen Housman for collecting the high resolution mass spectrometry data. ACJ and SCP were supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (Contract No. ORISE 1120-1120-99). NR 41 TC 13 Z9 13 U1 3 U2 49 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD JUL 23 PY 2013 VL 46 IS 14 BP 5416 EP 5422 DI 10.1021/ma401077d PG 7 WC Polymer Science SC Polymer Science GA 191ML UT WOS:000322417100002 ER PT J AU Mansi, I Frei, CR Pugh, MJ Makris, U Mortensen, EM AF Mansi, Ishak Frei, Christopher R. Pugh, Mary Jo Makris, Una Mortensen, Eric M. TI Statins and Musculoskeletal Conditions, Arthropathies, and Injuries SO JAMA INTERNAL MEDICINE LA English DT Article ID DENSITY-LIPOPROTEIN CHOLESTEROL; OF-THE-LITERATURE; SKELETAL-MUSCLE; GENERAL-PRACTICE; CREATINE-KINASE; TENDON-RUPTURE; THERAPY; MYOPATHY; EXERCISE; PAIN AB IMPORTANCE Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. OBJECTIVE To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. DESIGN A retrospective cohort study with propensity score matching. SETTING San Antonio Military Multi-Market. PARTICIPANTS Tricare Prime/Plus beneficiaries evaluated from October 1, 2003, to March 1, 2010. INTERVENTIONS Statin use during fiscal year 2005. On the basis of medication fills, patients were divided into 2 groups: statin users (received a statin for at least 90 days) and nonusers (never received a statin throughout the study period). MAIN OUTCOMES AND MEASURES Using patients' baseline characteristics, we generated a propensity score that was used to match statin users and nonusers; odds ratios (ORs) were determined for each outcome measure. Secondary analyses determined adjusted ORs for all patients who met study criteria and a subgroup of patients with no comorbidities identified using the Charlson Comorbidity Index. Sensitivity analysis further determined adjusted ORs for a subgroup of patients with no musculoskeletal diseases at baseline and a subgroup of patients who continued statin therapy for 2 years or more. The occurrence of musculoskeletal conditions was determined using prespecified groups of International Classification of Diseases, Ninth Revision, Clinical Modification codes: Msk1, all musculoskeletal diseases; Msk1a, arthropathies and related diseases; Msk1b, injury-related diseases (dislocation, sprain, strain); and Msk2, drug-associated musculoskeletal pain. RESULTS A total of 46 249 individuals met study criteria (13 626 statin users and 32 623 nonusers). Of these, we propensity score-matched 6967 statin users with 6967 nonusers. Among matched pairs, statin users had a higher OR for Msk1 (OR, 1.19; 95% CI, 1.08-1.30), Msk1b (1.13; 1.05-1.21), and Msk2 (1.09; 1.02-1.18); the OR for Msk1a was 1.07 (0.99-1.16; P = .07). Secondary and sensitivity analyses revealed higher adjusted ORs for statin users in all outcome groups. CONCLUSIONS AND RELEVANCE Musculoskeletal conditions, arthropathies, injuries, and pain are more common among statin users than among similar nonusers. The full spectrum of statins' musculoskeletal adverse events may not be fully explored, and further studies are warranted, especially in physically active individuals. C1 [Mansi, Ishak] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Mansi, Ishak] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Mansi, Ishak] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Pharmacotherapy Educ & Res Ctr, Sch Med, San Antonio, TX 78229 USA. [Pugh, Mary Jo] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. [Pugh, Mary Jo] South Texas Vet Affairs Hlth Care Syst, San Antonio, TX USA. [Makris, Una] Vet Affairs North Texas Hlth Care Syst, Div Rheumat Dis, Dept Gen Internal Med, Dallas, TX USA. [Makris, Una; Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Mortensen, Eric M.] Vet Affairs North Texas Hlth Care Syst, Dept Gen Internal Med, Dallas, TX USA. RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, 4500 S Lancaster Rd, Dallas, TX 75216 USA. EM ishak.mansi@va.gov OI Pugh, Mary Jo/0000-0003-4196-7763; Mortensen, Eric/0000-0002-3880-5563 FU National Institutes of Health (NIH) [RR025766] FX Dr Frei was supported by the National Institutes of Health (NIH) in the form of NIH/Clinical Research Scholar (KL2) career development award RR025766 during the conduct of this study. NR 63 TC 15 Z9 16 U1 1 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUL 22 PY 2013 VL 173 IS 14 BP 1318 EP 1326 DI 10.1001/jamainternmed.2013.6184 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 214TX UT WOS:000324160100009 ER PT J AU Taylor, PJ Maddux, JR Meissner, G Venkatasubramanian, R Bulman, G Pierce, J Gupta, R Bierschenk, J Caylor, C D'Angelo, J Ren, ZF AF Taylor, Patrick J. Maddux, Jay R. Meissner, Greg Venkatasubramanian, Rama Bulman, Gary Pierce, Jonathan Gupta, Rahul Bierschenk, Jim Caylor, Chris D'Angelo, Jonathan Ren, Zhifeng TI Controlled improvement in specific contact resistivity for thermoelectric materials by ion implantation SO APPLIED PHYSICS LETTERS LA English DT Article ID SINGLE-CRYSTALS; OHMIC CONTACTS; GAAS; TELLURIDE; BI2TE3; TRANSPORT; DEVICES AB To obtain reduced specific contact resistivity, iodine donors and silver acceptors were ion-implanted into n-type and p-type (Bi,Sb)(2)(Se,Te)(3) materials, respectively, to achieve > 10 times higher doping at the surface. Implantation into n-type materials caused the specific contact resistivity to decrease from 1.7 x 10(-6) Omega cm(2) to 4.5 x 10(-7) Omega cm(2). Implantation into p-type materials caused specific contact resistivity to decrease from 7.7 x 10(-7) Omega cm(2) to 2.7 x 10(-7) Omega cm(2). For implanted thin-film superlattices, the non-implanted values of 1.4 x 10(-7) Omega cm(2) and 5.3 x 10(-8) Omega cm(2) precipitously dropped below the detection limit after implantation, <= 10(-8) Omega cm(2). These reductions in specific contact resistivity are consistent with an increase in tunneling across the contact. (C) 2013 AIP Publishing LLC. C1 [Taylor, Patrick J.; Maddux, Jay R.; Meissner, Greg] US Army, Res Lab, Adelphi, MD 20783 USA. [Venkatasubramanian, Rama; Bulman, Gary; Pierce, Jonathan] RTI Int, Res Triangle Pk, NC 27709 USA. [Gupta, Rahul; Bierschenk, Jim] Marlow Ind, Dallas, TX 75238 USA. [Caylor, Chris; D'Angelo, Jonathan; Ren, Zhifeng] GMZ Energy, Waltham, MA 02453 USA. RP Taylor, PJ (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM patrick.j.taylor36.civ@mail.mil FU Defense Advanced Research Projects Agency (DARPA) FX The authors would like to acknowledge the support from the Defense Advanced Research Projects Agency (DARPA) under the Active Cooling Modules program and Harry Hier for assistance with C-TLM measurements. NR 24 TC 5 Z9 5 U1 2 U2 34 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 22 PY 2013 VL 103 IS 4 AR 043902 DI 10.1063/1.4816054 PG 4 WC Physics, Applied SC Physics GA 191IM UT WOS:000322406600132 ER PT J AU Vital-Lopez, FG Wallqvist, A Reifman, J AF Vital-Lopez, Francisco G. Wallqvist, Anders Reifman, Jaques TI Bridging the gap between gene expression and metabolic phenotype via kinetic models SO BMC SYSTEMS BIOLOGY LA English DT Article DE Gene expression; Kinetic models; Metabolic networks; S. cerevisiae; Transcriptomics; Fluxomics; Metabolomics ID TRANSCRIPTIONAL REGULATION; BIOCHEMICAL NETWORKS; CELLULAR-METABOLISM; YEAST; SYSTEMS; SENSITIVITIES; CONSTRAINTS; PREDICTION; CELLS AB Background: Despite the close association between gene expression and metabolism, experimental evidence shows that gene expression levels alone cannot predict metabolic phenotypes, indicating a knowledge gap in our understanding of how these processes are connected. Here, we present a method that integrates transcriptome, fluxome, and metabolome data using kinetic models to create a mechanistic link between gene expression and metabolism. Results: We developed a modeling framework to construct kinetic models that connect the transcriptional and metabolic responses of a cell to exogenous perturbations. The framework allowed us to avoid extensive experimental characterization, literature mining, and optimization problems by estimating most model parameters directly from fluxome and transcriptome data. We applied the framework to investigate how gene expression changes led to observed phenotypic alterations of Saccharomyces cerevisiae treated with weak organic acids (i.e., acetate, benzoate, propionate, or sorbate) and the histidine synthesis inhibitor 3-aminotriazole under steady-state conditions. We found that the transcriptional response led to alterations in yeast metabolism that mimicked measured metabolic fluxes and concentration changes. Further analyses generated mechanistic insights of how S. cerevisiae responds to these stresses. In particular, these results suggest that S. cerevisiae uses different regulation strategies for responding to these insults: regulation of two reactions accounted for most of the tolerance to the four weak organic acids, whereas the response to 3-aminotriazole was distributed among multiple reactions. Moreover, we observed that the magnitude of the gene expression changes was not directly correlated with their effect on the ability of S. cerevisiae to grow under these treatments. In addition, we identified another potential mechanism of action of 3-aminotriazole associated with the depletion of tetrahydrofolate. Conclusions: Our simulation results show that the modeling framework provided an accurate mechanistic link between gene expression and cellular metabolism. The proposed method allowed us to integrate transcriptome, fluxome, and metabolome data to determine and interpret important features of the physiological response of yeast to stresses. Importantly, given its flexibility and robustness, our approach can be applied to investigate the transcriptional-metabolic response in other cellular systems of medical and industrial relevance. C1 [Vital-Lopez, Francisco G.; Wallqvist, Anders; Reifman, Jaques] US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469 NR 39 TC 5 Z9 5 U1 1 U2 25 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD JUL 22 PY 2013 VL 7 AR 63 DI 10.1186/1752-0509-7-63 PG 16 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 193ZG UT WOS:000322599400001 PM 23875723 ER PT J AU Bigley, AN Xu, CF Henderson, TJ Harvey, SP Raushel, FM AF Bigley, Andrew N. Xu, Chengfu Henderson, Terry J. Harvey, Steven P. Raushel, Frank M. TI Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ORGANOPHOSPHATE NERVE AGENTS; BACTERIAL PHOSPHOTRIESTERASE; PSEUDOMONAS-DIMINUTA; DIRECTED EVOLUTION; HYDROLASE; SUBSTRATE; TOXICITY; SITE; DEGRADATION; SPECIFICITY AB The V-type nerve agents (VX and VR) are among the most toxic substances known. The high toxicity and environmental persistence of VX make the development of novel decontamination methods particularly important. The enzyme phosphotriesterase (PTE) is capable of hydrolyzing VX but with an enzymatic efficiency more than 5 orders of magnitude lower than with its best substrate, paraoxon. PTE has previously proven amenable to directed evolution for the improvement of catalytic activity against selected compounds through the manipulation of active-site residues. Here, a series of sequential two-site mutational libraries encompassing 12 active-site residues of PTE was created. The libraries were screened for catalytic activity against a new VX analogue, DEVX, which contains the same thiolate leaving group of VX coupled to a diethoxyphosphate core rather than the ethoxymethylphosphonate core of VX. The evolved catalytic activity with DEVX was enhanced 26-fold relative to wild-type PTE. Further improvements were facilitated by targeted error-prone PCR mutagenesis of loop-7, and additional PTE variants were identified with up to a 78-fold increase in the rate of DEVX hydrolysis. The best mutant hydrolyzed the racemic nerve agent VX with a value of k(cat)/K-m = 7 x 10(4) M-1 s(-1), a 230-fold improvement relative to wild-type PTE. The highest turnover number achieved by the mutants created for this investigation was 137 s(-1), an enhancement of 152-fold relative to wild-type PTE. The stereoselectivity for the hydrolysis of the two enantiomers of VX was relatively low. These engineered mutants of PTE are the best catalysts ever reported for the hydrolysis of nerve agent VX. C1 [Bigley, Andrew N.; Xu, Chengfu; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA. [Henderson, Terry J.; Harvey, Steven P.] US Army, Edgewood Chem Biol Ctr, Res & Technol Directorate, Biochem Branch,RDCB DRB C, Aberdeen Proving Ground, MD USA. RP Raushel, FM (reprint author), Texas A&M Univ, Dept Chem, POB 30012, College Stn, TX 77842 USA. EM raushel@tamu.edu RI Raushel, Frank/B-7125-2015 OI Raushel, Frank/0000-0002-5918-3089 FU NIH [GM68550]; Defense Threat Reduction Agency FX This work was supported in part by the NIH (GM68550). We gratefully acknowledge the Defense Threat Reduction Agency for funding the work conducted at the Edgewood Chemical Biological Center. NR 30 TC 20 Z9 23 U1 9 U2 76 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 17 PY 2013 VL 135 IS 28 BP 10426 EP 10432 DI 10.1021/ja402832z PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 187FT UT WOS:000322103000052 PM 23789980 ER PT J AU Moran, JM Kelley, WM Heatherton, TF AF Moran, Joseph M. Kelley, William M. Heatherton, Todd F. TI What can the organization of the brain's default mode network tell us about self-knowledge? SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE cognitive neuroscience; self-reflection; medial prefrontal cortex; posterior cingulate cortex; default mode network ID MEDIAL PREFRONTAL CORTEX; CORTICAL MIDLINE STRUCTURES; RHESUS-MONKEY; SOCIAL COGNITION; CEREBRAL-CORTEX; RESTING BRAIN; CLOSE OTHERS; NEURAL BASIS; FMRI; MEMORY AB Understanding ourselves has been a fundamental topic for psychologists and philosophers alike. In this paper we review the evidence linking specific brain structures to self-reflection. The brain regions most associated with self-reflection are the posterior cingulate and medial prefrontal (mPFC) cortices, together known as the cortical midline structures (CMSs). We review evidence arguing that self-reflection is special in memory, while noting that these brain regions are often engaged when we think about others in our social worlds. Based on the CMSs' patterns of connectivity and activity, we speculate about three possible interpretations of their role in supporting self-reflection that are somewhat overlapping, and not intended to be mutually exclusive. First, self may be a powerful, but ordinary case for a cognitive system specialized for thinking about people. Second, mPFC may serve as a processing "hub," binding together information from all sensory modalities with internally generated information. Third, mPFC may serve as a cortical director of thought, helping to guide moment-by-moment conscious processing. Suggestions are made for future research avenues aimed at testing such possibilities. C1 [Moran, Joseph M.] USA, Army Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Moran, Joseph M.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA. [Kelley, William M.; Heatherton, Todd F.] Dartmouth Coll, Hanover, NH 03755 USA. RP Moran, JM (reprint author), Harvard Univ, Ctr Brain Sci, 52 Oxford St 290, Cambridge, MA 02138 USA. EM jmoran@wjh.harvard.edu FU National Institutes of Health [R01MH059282] FX This work was supported by a grant from the National Institutes of Health (R01MH059282) to Todd F. Heatherton. NR 61 TC 0 Z9 0 U1 2 U2 21 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD JUL 17 PY 2013 VL 7 AR 39 DI 10.3389/fnhum.2013.00391 PG 6 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 184KS UT WOS:000321889100001 ER PT J AU Vento, TJ Calvano, TP Cole, DW Mende, K Rini, EA Tully, CC Landrum, ML Zera, W Guymon, CH Yu, X Beckius, ML Cheatle, KA Murray, CK AF Vento, Todd J. Calvano, Tatjana P. Cole, David W. Mende, Katrin Rini, Elizabeth A. Tully, Charla C. Landrum, Michael L. Zera, Wendy Guymon, Charles H. Yu, Xin Beckius, Miriam L. Cheatle, Kristelle A. Murray, Clinton K. TI Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan SO BMC INFECTIOUS DISEASES LA English DT Article DE Deployment; Malaria chemoprophylaxis; Doxycycline; Military; Staphylococcus aureus; Colonization ID FIELD GEL-ELECTROPHORESIS; WAR WOUNDS; EXTREMITY INJURIES; SKIN INFECTIONS; RISK-FACTORS; RESISTANT; IRAQ; PREVENTION; COMPLICATIONS; EPIDEMIOLOGY AB Background: Staphylococcus aureus [methicillin-resistant and methicillin-susceptible (MRSA/MSSA)] is a leading cause of infections in military personnel, but there are limited data regarding baseline colonization of individuals while deployed. We conducted a pilot study to screen non-deployed and deployed healthy military service members for MRSA/MSSA colonization at various anatomic sites and assessed isolates for molecular differences. Methods: Colonization point-prevalence of 101 military personnel in the US and 100 in Afghanistan was determined by swabbing 7 anatomic sites. US-based individuals had received no antibiotics within 30 days, and Afghanistan-deployed personnel were taking doxycycline for malaria prophylaxis. Isolates underwent identification and testing for antimicrobial resistance, virulence factors, and pulsed-field type (PFT). Results: 4 individuals in the US (4 isolates-3 oropharynx, 1 perirectal) and 4 in Afghanistan (6 isolates-2 oropharynx, 2 nare, 1 hand, 1 foot) were colonized with MRSA. Among US-based personnel, 3 had USA300 (1 PVL+) and 1 USA700. Among Afghanistan-based personnel, 1 had USA300 (PVL+), 1 USA800 and 2 USA1000. MSSA was present in 40 (71 isolates-25 oropharynx, 15 nare) of the US-based and 32 (65 isolates-16 oropharynx, 24 nare) of the Afghanistan-based individuals. 56 (79%) US and 41(63%) Afghanistan-based individuals had MSSA isolates recovered from extra-nare sites. The most common MSSA PFTs were USA200 (9 isolates) in the US and USA800 (7 isolates) in Afghanistan. MRSA/MSSA isolates were susceptible to doxycycline in all but 3 personnel (1 US, 2 Afghanistan; all were MSSA isolates that carried tetM). Conclusion: MRSA and MSSA colonization of military personnel was not associated with deployment status or doxycycline exposure. Higher S. aureus oropharynx colonization rates were observed and may warrant changes in decolonization practices. C1 [Vento, Todd J.; Calvano, Tatjana P.; Mende, Katrin; Rini, Elizabeth A.; Tully, Charla C.; Landrum, Michael L.; Zera, Wendy; Yu, Xin; Beckius, Miriam L.; Cheatle, Kristelle A.; Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Vento, Todd J.; Mende, Katrin; Landrum, Michael L.; Zera, Wendy; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Cole, David W.] Blanch Field Army Community Hosp, Ft Campbell, KY USA. [Guymon, Charles H.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.k.murray.mil@mail.mil FU Armed Forces Health Surveillance Center FX This work was supported by the Armed Forces Health Surveillance Center including the Global Emerging Infectious System. NR 38 TC 7 Z9 7 U1 3 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUL 16 PY 2013 VL 13 AR 325 DI 10.1186/1471-2334-13-325 PG 9 WC Infectious Diseases SC Infectious Diseases GA 185KU UT WOS:000321967400001 PM 24060181 ER PT J AU Ter-Gabrielyan, N Fromzel, V Mu, X Meissner, H Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Mu, X. Meissner, H. Dubinskii, M. TI Resonantly pumped single-mode channel waveguide Er:YAG laser with nearly quantum defect limited efficiency SO OPTICS LETTERS LA English DT Article ID DOUBLE-CLAD; FIBER AB We demonstrated the continuous-wave operation of a resonantly pumped Er:YAG single-mode channel waveguide laser with diffraction-limited output and nearly quantum defect limited efficiency. Using a longitudinally core-pumped, nearly square (61.2 mu m x 61.6 mu m) Er3+: YAG waveguide embedded in an undoped YAG cladding, an output power of 9.1 W with a slope efficiency of 92.8% (versus absorbed pump power) has been obtained. To the best of our knowledge, this optical-to-optical efficiency is the highest ever demonstrated for a channel waveguide laser. (C) 2013 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA. [Mu, X.; Meissner, H.] Onyx Opt Inc, Dublin, CA 94658 USA. RP Ter-Gabrielyan, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 13 TC 14 Z9 15 U1 1 U2 24 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 15 PY 2013 VL 38 IS 14 BP 2431 EP 2433 DI 10.1364/OL.38.002431 PG 3 WC Optics SC Optics GA 182UT UT WOS:000321770900020 PM 23939071 ER PT J AU Sobarzo, A Groseth, A Dolnik, O Becker, S Lutwama, JJ Perelman, E Yavelsky, V Muhammad, M Kuehne, AI Marks, RS Dye, JM Lobel, L AF Sobarzo, Ariel Groseth, Allison Dolnik, Olga Becker, Stephan Lutwama, Julius Julian Perelman, Eddie Yavelsky, Victoria Muhammad, Majidat Kuehne, Ana I. Marks, Robert S. Dye, John M. Lobel, Leslie TI Profile and Persistence of the Virus-Specific Neutralizing Humoral Immune Response in Human Survivors of Sudan Ebolavirus (Gulu) SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE ebolavirus; immune response; epitopes; antibodies; sera screening; serological profiling ID PROTECTS NONHUMAN-PRIMATES; VALLEY FEVER VIRUS; HEMORRHAGIC-FEVER; ANTIBODY; INFECTION; NUCLEOPROTEIN; GLYCOPROTEIN; VACCINE; GABON; IGG AB To better understand humoral immunity following ebolavirus infection, a serological study of the humoral immune response against the individual viral proteins of Sudan ebolavirus (Gulu) in human survivors was performed. An enzyme-linked immunosorbent assay specific for full-length recombinant viral proteins NP, VP30, VP40, and GP(1-649) (GP lacking the transmembrane domain) of Sudan ebolavirus (Gulu) was used as well as a plaque reduction neutralization test. Serum samples from human survivors, which were collected up to 10 years following recovery, were screened and analyzed. Results demonstrate that samples obtained 10 years following infection contain virus-specific antibodies that can neutralize virus. Neutralization correlates well with immunoreactivity against the viral proteins NP, VP30, and GP(1-649). Sera from individuals who died or those with no documented infection but immunoreactive to ebolavirus did not neutralize. This work provides insight into the duration, profile of immunoreactivity, and neutralization capacity of the humoral immune response in ebolavirus survivors. C1 [Sobarzo, Ariel; Yavelsky, Victoria; Lobel, Leslie] Ben Gurion Univ Negev, Dept Virol, IL-84105 Beer Sheva, Israel. [Groseth, Allison; Dolnik, Olga; Becker, Stephan] Univ Marburg, Inst Virol, D-35032 Marburg, Germany. [Lutwama, Julius Julian] Emerging & Reemerging Infect Uganda Virus Res Ins, Dept Arbovirol, Entebbe, Uganda. [Perelman, Eddie; Marks, Robert S.] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva, Israel. [Muhammad, Majidat; Kuehne, Ana I.; Dye, John M.] US Army Med Res Inst Infect Dis, Virol Div, Ft Detrick, MD USA. RP Lobel, L (reprint author), Ben Gurion Univ Negev, Fac Hlth Sci, Dept Virol & Dev Genet, Pathol Bldg 231, Beer Sheva, Israel. EM llobel@bgu.ac.il RI Becker, Stephan/A-1065-2010 OI Becker, Stephan/0000-0002-2794-5659 FU National Institute of Biotechnology in the Negev, Beersheva, Israel; Feldman Family Foundation FX The authors acknowledge the support of the National Institute of Biotechnology in the Negev, Beersheva, Israel, and the Feldman Family Foundation. NR 39 TC 18 Z9 19 U1 0 U2 11 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2013 VL 208 IS 2 BP 299 EP + DI 10.1093/infdis/jit162 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 170NF UT WOS:000320858500002 PM 23585686 ER PT J AU Smith, LM Hensley, LE Geisbert, TW Johnson, J Stossel, A Honko, A Yen, JY Geisbert, J Paragas, J Fritz, E Olinger, G Young, HA Rubins, KH Karp, CL AF Smith, Lauren M. Hensley, Lisa E. Geisbert, Thomas W. Johnson, Joshua Stossel, Andrea Honko, Anna Yen, Judy Y. Geisbert, Joan Paragas, Jason Fritz, Elizabeth Olinger, Gene Young, Howard A. Rubins, Kathleen H. Karp, Christopher L. TI Interferon-beta Therapy Prolongs Survival in Rhesus Macaque Models of Ebola and Marburg Hemorrhagic Fever SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Filovirus; IFN-beta; Ebola virus; Marburg virus; type I interferon ID VIRUS-INFECTED PATIENTS; NECROSIS-FACTOR-ALPHA; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; IFN-ALPHA; GENE-EXPRESSION; DENDRITIC CELLS; TNF-ALPHA; IN-VITRO; PATHOGENESIS AB There is a clear need for novel, effective therapeutic approaches to hemorrhagic fever due to filoviruses. Ebola virus hemorrhagic fever is associated with robust interferon (IFN)-alpha production, with plasma concentrations of IFN-alpha that greatly (60- to 100-fold) exceed those seen in other viral infections, but little IFN-beta production. While all of the type I IFNs signal through the same receptor complex, both quantitative and qualitative differences in biological activity are observed after stimulation of the receptor complex with different type I IFNs. Taken together, this suggested potential for IFN-beta therapy in filovirus infection. Here we show that early postexposure treatment with IFN-beta significantly increased survival time of rhesus macaques infected with a lethal dose of Ebola virus, although it failed to alter mortality. Early treatment with IFN-beta also significantly increased survival time after Marburg virus infection. IFN-beta may have promise as an adjunctive postexposure therapy in filovirus infection. C1 [Smith, Lauren M.; Rubins, Kathleen H.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Hensley, Lisa E.; Geisbert, Thomas W.; Johnson, Joshua; Stossel, Andrea; Honko, Anna; Yen, Judy Y.; Geisbert, Joan; Paragas, Jason; Fritz, Elizabeth; Olinger, Gene] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Young, Howard A.] NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. [Karp, Christopher L.] Cincinnati Childrens Hosp Res Fdn, Div Mol Immunol, Cincinnati, OH USA. [Karp, Christopher L.] Univ Cincinnati, Coll Med, Cincinnati, OH 45221 USA. RP Karp, CL (reprint author), CCHMC, 3333 Burnet Ave, Cincinnati, OH USA. EM chris.karp@cchmc.org OI Karp, Christopher/0000-0002-0832-2659 FU JSTO-CBD/DTRA [19595 4.10009_06_RD_B, 19585 4.10037_07_RD_B]; National Institute of Allergy and Infectious Diseases [AI053539, AI057159]; Cincinnati Children's Hospital Medical Center (Translational Research Initiative Grant); US Army Medical Research and Material Command administered by the Oak Ridge Institute for Science and Education, a Stanford URP Major Grant; National Science Foundation Graduate Research Fellowship [DGE-1147470] FX This work was funded by JSTO-CBD/DTRA (Projects 19595 4.10009_06_RD_B and 19585 4.10037_07_RD_B to L. E. H.), National Institute of Allergy and Infectious Diseases (grants AI053539 to C. L. K. and AI057159 to L. E. H.), and Cincinnati Children's Hospital Medical Center (Translational Research Initiative Grant to C. L. K). L. M. S. was supported by an appointment to the Student Research Participation Program at the US Army Medical Research and Material Command administered by the Oak Ridge Institute for Science and Education, a Stanford URP Major Grant, and National Science Foundation Graduate Research Fellowship DGE-1147470. NR 50 TC 40 Z9 46 U1 0 U2 23 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2013 VL 208 IS 2 BP 310 EP 318 DI 10.1093/infdis/jis921 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 170NF UT WOS:000320858500019 PM 23255566 ER PT J AU Chaorattanakawee, S Tyner, SD Lon, C Yingyuen, K Ruttvisutinunt, W Sundrakes, S Sai-gnam, P Johnson, JD Walsh, DS Saunders, DL Lanteri, CA AF Chaorattanakawee, Suwanna Tyner, Stuart D. Lon, Chanthap Yingyuen, Kritsanai Ruttvisutinunt, Wiriya Sundrakes, Siratchana Sai-gnam, Piyaporn Johnson, Jacob D. Walsh, Douglas S. Saunders, David L. Lanteri, Charlotte A. TI Direct comparison of the histidine-rich protein-2 enzyme-linked immunosorbent assay (HRP-2 ELISA) and malaria SYBR green I fluorescence (MSF) drug sensitivity tests in Plasmodium falciparum reference clones and fresh ex vivo field isolates from Cambodia SO MALARIA JOURNAL LA English DT Article DE Immediate ex vivo Plasmodium falciparum drug susceptibility testing; HRP-2 ELISA; Malaria SYBR green fluorescence assay; Cambodia ID ARTEMISININ RESISTANCE; CONTINUOUS CULTURE; VITRO RESISTANCE; SUSCEPTIBILITY; INVITRO; CHLOROQUINE; PERFORMANCE; SAMPLES AB Background: Performance of the histidine-rich protein-2 enzyme-linked immunosorbent assay (HRP-2 ELISA) and malaria SYBR Green I fluorescence (MSF) drug sensitivity tests were directly compared using Plasmodium falciparum reference strains and fresh ex vivo isolates from Cambodia against a panel of standard anti-malarials. The objective was to determine which of these two common assays is more appropriate for studying drug susceptibility of "immediate ex vivo" (IEV) isolates, analysed without culture adaption, in a region of relatively low malaria transmission. Methods: Using the HRP-2 and MSF methods, the 50% inhibitory concentration (IC50) values against a panel of malaria drugs were determined for P. falciparum reference clones (W2, D6, 3D7 and K1) and 41 IEV clinical isolates from an area of multidrug resistance in Cambodia. Comparison of the IC50 values from the two methods was made using Wilcoxon matched pair tests and Pearson's correlation. The lower limit of parasitaemia detection for both methods was determined for reference clones and IEV isolates. Since human white blood cell (WBC) DNA in clinical samples is known to reduce MSF assay sensitivity, SYBR Green I fluorescence linearity of P. falciparum samples spiked with WBCs was evaluated to assess the relative degree to which MSF sensitivity is reduced in clinical samples. Results: IC50 values correlated well between the HRP-2 and MSF methods when testing either P. falciparum reference clones or IEV isolates against 4-aminoquinolines (chloroquine, piperaquine and quinine) and the quinoline methanol mefloquine (Pearson r = 0.85-0.99 for reference clones and 0.56-0.84 for IEV isolates), whereas a weaker IC50 value correlation between methods was noted when testing artemisinins against reference clones and lack of correlation when testing IEV isolates. The HRP-2 ELISA produced a higher overall success rate (90% for producing IC50 best-fit sigmoidal curves), relative to only a 40% success rate for the MSF assay, when evaluating ex vivo Cambodian isolates. Reduced sensitivity of the MSF assay is likely due to an interference of WBCs in clinical samples. Conclusions: For clinical samples not depleted of WBCs, HRP-2 ELISA is superior to the MSF assay at evaluating fresh P. falciparum field isolates with low parasitaemia (<0.2%) generally observed in Southeast Asia. C1 [Chaorattanakawee, Suwanna; Tyner, Stuart D.; Lon, Chanthap; Yingyuen, Kritsanai; Ruttvisutinunt, Wiriya; Sundrakes, Siratchana; Sai-gnam, Piyaporn; Walsh, Douglas S.; Saunders, David L.; Lanteri, Charlotte A.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Johnson, Jacob D.] Kenya Govt Med Res Ctr, Dept Emerging Infect Dis Program, US Army Med Res Unit Kenya, Walter Reed Project, Kisumu, Kenya. RP Lanteri, CA (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM charlotte.lanteri@afrims.org FU Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense FX We are grateful to the AFRIMS and Cambodian clinical and laboratory field teams for conducting microscopy and their technical support. We thank Mr. William Ellis at the Walter Reed Army Institute of Research (WRAIR) for providing us with test drugs. We are appreciative of our colleagues at AFRIMS for their assistance: Dr. Delia Bethell for reviewing the paper, Ms. Somporn Krasaesub for advice on statistical analysis, and Ms. Panjaporn Chaichana for assistance with inoculum effect experiments. We thank Mr. Hoseah Akala, of the United States Army Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kisumu, for kindly providing data on the parasitaemia of P. falciparum isolates collected in Kenya. This work was funded by the Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense. NR 35 TC 11 Z9 12 U1 2 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUL 12 PY 2013 VL 12 AR 239 DI 10.1186/1475-2875-12-239 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 184WL UT WOS:000321924300001 PM 23849006 ER PT J AU Hu, X Compton, JR AbdulHameed, MDM Marchand, CL Robertson, KL Leary, DH Jadhav, A Hershfield, JR Wallqvist, A Friedlander, AM Legler, PM AF Hu, Xin Compton, Jaimee R. AbdulHameed, Mohamed Diwan M. Marchand, Charles L. Robertson, Kelly L. Leary, Dagmar H. Jadhav, Ajit Hershfield, Jeremy R. Wallqvist, Anders Friedlander, Arthur M. Legler, Patricia M. TI 3-Substituted lndole Inhibitors Against Francisella tularensis Fabl Identified by Structure-Based Virtual Screening SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID CARRIER PROTEIN REDUCTASE; ENOYL-ACP REDUCTASE; RESISTANCE-DETERMINING REGION; IN-VITRO ACTIVITY; ESCHERICHIA-COLI; STREPTOCOCCUS-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS; YERSINIA-PESTIS; MYCOBACTERIUM-TUBERCULOSIS; ANTIBACTERIAL AGENTS AB In this study, we describe novel inhibitors against Francisella tularensis SchuS4 FabI identified from structure-based in silico screening with integrated molecular dynamics simulations to account for induced fit of a flexible loop crucial for inhibitor binding. Two 3-substituted indoles, 54 and 57, preferentially bound the NAD(+) form of the enzyme and inhibited growth of F. tularensis SchuS4 at concentrations near that of their measured K-i. While 57 was species-specific, 54 showed a broader spectrum of growth inhibition against F. tularensis, Bacillus anthracis, and Staphylococcus aureus. Binding interaction analysis in conjunction with site-directed mutagenesis revealed key residues and elements that contribute to inhibitor binding and species specificity. Mutation of Arg-96, a poorly conserved residue opposite the loop, was unexpectedly found to enhance inhibitor binding in the R96G and R96M variants. This residue may affect the stability and closure of the flexible loop to enhance inhibitor (or substrate) binding. C1 [Compton, Jaimee R.; Robertson, Kelly L.; Leary, Dagmar H.; Legler, Patricia M.] USN, Ctr Biomol Sci & Engn, Res Labs, Washington, DC 20375 USA. [Compton, Jaimee R.] Nova Res Inc, Alexandria, VA 22308 USA. [Hu, Xin; Jadhav, Ajit] Natl Ctr Adv Translat Sci, NIH Chem Genom Ctr, Rockville, MD 20850 USA. [Marchand, Charles L.; Hershfield, Jeremy R.; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [AbdulHameed, Mohamed Diwan M.; Wallqvist, Anders] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Legler, PM (reprint author), USN, Ctr Biomol Sci & Engn, Res Labs, Washington, DC 20375 USA. EM patricia.legler@nrl.navy.mil RI AbdulHameed, Mohamed Diwan M/O-3088-2015 OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084 FU U.S. Defense Threat Reduction Agency [TMTI0004_09_BH_T, CBM.THERB.02.11.RD.012] FX We would like to acknowledge Greg Tawa for helpful discussions and Peter J. Tonge for supplying the initial plasmid DNA construct. We would also like to acknowledge Lynda Miller and Stephanie Halasohoris for excellent technical help. This work was funded by the U.S. Defense Threat Reduction Agency awards TMTI0004_09_BH_T and CBM.THERB.02.11.RD.012. The opinions or assertions contained herein belong to the authors and are not necessarily the official views of the U.S. Army, U.S. Navy or the U.S. Department of Defense. NR 74 TC 9 Z9 9 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 11 PY 2013 VL 56 IS 13 BP 5275 EP 5287 DI 10.1021/jm4001242 PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 184IV UT WOS:000321884200005 PM 23815100 ER PT J AU Bae, SY Winemiller, MD AF Bae, Su Y. Winemiller, Mark D. TI Mechanistic Insights into the Hydrolysis of 2-Chloroethyl Ethyl Sulfide: The Expanded Roles of Sulfonium Salts SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID NUCLEOPHILIC SOLVENT ASSISTANCE; S(N)1 IONIC DISSOCIATION; BUFF INTEGRAL-FUNCTIONS; SATURATED CARBON-ATOM; ACTIVITY-COEFFICIENTS; MUSTARD DERIVATIVES; SN2-SN1 SPECTRUM; WATER CLUSTERS; SULFUR MUSTARD; NEIGHBORING SULFUR AB The hydrolysis of 2-chloroethyl ethyl sulfide has been examined in an effort to better understand its mechanism under more concentrated conditions Two salts formed during hydrolysis were synthesized, and an emphasis was placed on determining their effect on the reaction as it proceeded. Unexpected changes in mechanism were seen when excess chloride was added to the reaction. By measuring rates and product distributions as the products were added back into the hydrolysis, a mechanism was developed. The formation of these sulfonium salts represents additional products in the disappearance of 2-chloroethyl ethyl sulfide with k(3) in particular causing a deviation away from expected first-order behavior. Sulfonium salts 3 and 4 do not appear to interconvert, and the system as a whole had fewer pathways available than previously proposed. Initial conditions for studying the hydrolysis were very important and could lead to different conclusions depending on the conditions used This work will aid in better understanding the hydrolysis of the very toxic chemical warfare agent mustard (bis(2-chloroethyl)sulfide) in the environment and during its decontamination. C1 [Bae, Su Y.; Winemiller, Mark D.] USA, Res & Technol Directorate, ECBC, Aberdeen Proving Ground, MD 21010 USA. RP Winemiller, MD (reprint author), USA, Res & Technol Directorate, ECBC, Aberdeen Proving Ground, MD 21010 USA. EM mark.d.winemiller.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office (DTRA-JSTO) [CBCALL12-TAS-2-0130] FX The authors would like to thank Dr. Sari Paikoff at the Defense Threat Reduction Agency-Joint Science and Technology Office (DTRA-JSTO) for funding this work under contract (CBCALL12-TAS-2-0130), Dr. David B. Cullum at Cornell University for helpful discussions and insights, and Mr. Dennis Bevilacqua at the Edgewood Chemical Biological Center for programming assistance with the Bruker 500. NR 69 TC 3 Z9 3 U1 1 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD JUL 5 PY 2013 VL 78 IS 13 BP 6457 EP 6470 DI 10.1021/jo400392b PG 14 WC Chemistry, Organic SC Chemistry GA 180PA UT WOS:000321605900009 PM 23767819 ER PT J AU Aprelikova, O Palla, J Hibler, B Yu, X Greer, YE Yi, M Stephens, R Maxwell, GL Jazaeri, A Risinger, JI Rubin, JS Niederhuber, J AF Aprelikova, O. Palla, J. Hibler, B. Yu, X. Greer, Y. E. Yi, M. Stephens, R. Maxwell, G. L. Jazaeri, A. Risinger, J. I. Rubin, J. S. Niederhuber, J. TI Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility SO ONCOGENE LA English DT Article DE cancer-associated fibroblasts; endometrial cancer; microRNA; miR-148a; WNT10B ID NUCLEAR BETA-CATENIN; BREAST-CANCER; GASTRIC-CANCER; STROMAL CELLS; ENDOMETRIAL CANCER; OVARIAN CARCINOMAS; PROLIFERATION; MICRORNAS; DNA; CARCINOGENESIS AB The tumor microenvironment has an important role in cancer progression. Here we show that miR-148a is downregulated in 15 out of 16 samples (94%) of cancer-associated fibroblasts (CAFs) compared with matched normal tissue fibroblasts (NFs) established from patients with endometrial cancer. Laser-capture microdissection of stromal cells from normal tissue and endometrial cancer confirmed this observation. Treatment of cells with 5-aza-deoxycytidine stimulated the expression of miR-148a in the majority of CAFs implicating DNA methylation in the regulation of miR-148a expression. Investigation of miR-148a function in fibroblasts demonstrated that conditioned media (CM) from CAFs overexpressing miR-148a significantly impaired the migration of five endometrial cancer cell lines without affecting their growth rates in co-culture experiments. Among predicted miR-148a target genes are two WNT family members, WNT1 and WNT10B. Activation of the WNT/b-catenin pathway in CAFs was confirmed by microarray analysis of gene expression and increased activity of the SuperTOPFlash luciferase reporter. We found elevated levels of WNT10B protein in CAFs and its level decreased when miR-148a was re-introduced by lentiviral infection. The 3'-UTR of WNT10B, cloned downstream of luciferase cDNA, suppressed luciferase activity when co-expressed with miR-148a indicating that WNT10B is a direct target of miR-148a. In contrast to the effect of miR-148a, WNT10B stimulated migration of endometrial cancer cell lines. Our findings have defined a molecular mechanism in the tumor microenvironment that is a novel target for cancer therapy. C1 [Aprelikova, O.; Palla, J.; Hibler, B.; Yu, X.; Niederhuber, J.] Canc & Cell Biol Branch, Bethesda, MD USA. [Greer, Y. E.; Rubin, J. S.] NCI, Cellular & Mol Biol Lab, Bethesda, MD 20892 USA. [Yi, M.; Stephens, R.] SAIC Inc, Frederick, MD USA. [Maxwell, G. L.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Jazaeri, A.] Univ Virginia, Charlottesville, VA USA. [Risinger, J. I.] Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI USA. RP Aprelikova, O (reprint author), NCI, Bldg 37,Rm 1042,9000 Rockville Pike, Bethesda, MD 20892 USA. EM apreliko@mail.nih.gov; rubinj@mail.nih.gov RI Jazaeri, Amir/I-3458-2015 OI Jazaeri, Amir/0000-0003-4335-4151 FU Intramural Research Program of National Institutes of Health; National Cancer Institute; Center for Cancer Research FX We thank Julie Oliver, Tracy Litzi, and Shelley Hoover for help with laser capture microdissection, Dr Xin Wei Wang (NCI) for the WNT10B expression vector and Dr Randall Moon (University of Washington) for the SuperTOPFlash and SuperFOPFlash constructs. This work was supported by the Intramural Research Program of National Institutes of Health, National Cancer Institute, and Center for Cancer Research. NR 50 TC 47 Z9 49 U1 0 U2 21 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0950-9232 J9 ONCOGENE JI Oncogene PD JUL 4 PY 2013 VL 32 IS 27 BP 3246 EP 3253 DI 10.1038/onc.2012.351 PG 8 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA 176JZ UT WOS:000321301600004 PM 22890324 ER PT J AU Harbach, RE Kitching, IJ Culverwell, CL Howard, TM Linton, YM AF Harbach, Ralph E. Kitching, Ian J. Culverwell, C. Lorna Howard, Theresa M. Linton, Yvonne-Marie TI Nyx pholeocola, a new genus and cavernicolous species of tribe Aedini (Diptera: Culicidae) from southern Thailand based on morphological and molecular data SO ZOOTAXA LA English DT Article DE Nyx gen. n.; Nyx pholeocola sp n.; COI barcode; ITS2; mosquito; taxonomy; systematics AB Nyx Harbach & Linton, gen. nov., is introduced as a new mosquito genus of tribe Aedini for a previously unknown cave-dwelling species, Nyx pholeocola Linton & Harbach, sp. nov., from southern Thailand. A diagnosis of the genus is provided that features unique anatomical characters of the adult, pupal and larval stages of the type species. The affinities of Nyx are discussed in terms of its position in the phylogeny of Aedini. Nyx is more closely related to Borichinda and Isoaedes than to other genera of tribe Aedini. Salient differences that distinguish these three genera are contrasted. The male and female genitalia, pupa and fourth-instar larva of the new species are illustrated. DNA sequence for the second nuclear internal spacer region (ITS2) and the 658-bp barcode fragment of the mitochondrial cytochrome c oxidase I (COI) gene reveal very low similarity with published sequences, supporting the unique status of the new species. C1 [Harbach, Ralph E.; Kitching, Ian J.; Culverwell, C. Lorna; Howard, Theresa M.] NHM, Dept Life Sci, London SW7 5BD, England. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Linton, Yvonne-Marie] Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. RP Harbach, RE (reprint author), NHM, Dept Life Sci, Cromwell Rd, London SW7 5BD, England. EM r.harbach@nhm.ac.uk; i.kitching@nhm.ac.uk; l.culverwell@nhm.ac.uk; t.howard@nhm.ac.uk; lintony@si.edu RI Culverwell, Lorna/N-3520-2014 OI Culverwell, Lorna/0000-0003-0755-5079 FU Royal Caribbean Cruises (The ScholarShip LLC); Friends of the Natural History Museum FX Fieldwork during which Nyx pholeocola was discovered was funded by Royal Caribbean Cruises (The ScholarShip LLC) and Friends of the Natural History Museum through donations to support the efforts of the Mosquito Barcoding Initiative (MBI, http://mosquitobarcode.org/). We are especially grateful to Ravinder S. Bhatia (Vice President, The ScholarShip) for his scientific and logistical support, Mark Isenstadt (Director, Vector Solutions, Bangkok, Thailand) for facilitating field collections, and Rudy Meiswinkel, Magdalena Zarowiecki and Dean Smallwood for their assistance in the field. This manuscript was prepared in part while YML held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the US Department of the Army or the US Department of Defense. NR 10 TC 3 Z9 4 U1 0 U2 1 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 J9 ZOOTAXA JI Zootaxa PD JUL 3 PY 2013 VL 3683 IS 2 BP 159 EP 177 DI 10.11646/zootaxa.3683.2.5 PG 19 WC Zoology SC Zoology GA 174UO UT WOS:000321181200005 PM 25250444 ER PT J AU Eckard, C Cole, R Lockwood, J Torres, DM Williams, CD Shaw, JC Harrison, SA AF Eckard, Carly Cole, Renee Lockwood, Joshua Torres, Dawn M. Williams, Christopher D. Shaw, Janet C. Harrison, Stephen A. TI Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial SO THERAPEUTIC ADVANCES IN GASTROENTEROLOGY LA English DT Article DE NAFLD; diet; lifestyle modification; fatty liver; treatment; low fat; diabetes ID MODERATE WEIGHT-REDUCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; LOW-CARBOHYDRATE; OBESE-PATIENTS; STEATOHEPATITIS; NAFLD; DIET; SENSITIVITY AB Background and aims: Nonalcoholic fatty liver disease (NAFLD) is now recognized as part of the metabolic syndrome, and is specifically related to obesity and insulin resistance. Lifestyle modification is advocated for the treatment of NAFLD, but few studies have evaluated its impact on liver histology. The purpose of this study was to investigate which, if any, specific diet and exercise recommendations are associated with histopathologic changes. Methods: A total of 56 participants were randomly assigned to 1 of 4 lifestyle modification subgroups for 6 months: standard care, low-fat diet and moderate exercise, moderate-fat/lowprocessed- carbohydrate diet and moderate exercise, or moderate exercise only. All subjects had biopsy-proven NAFLD, to include nonalcoholic steatohepatitis (NASH), and received a repeat 6-month biopsy to detect histopathologic changes. Other measures included blood assay of liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), fasting glucose, serum insulin, lipid panel, body weight, dietary intake, fat mass, and fitness level. Results: Among the 41 participants who completed the study (88% with NASH), a significant change was found in pre- to post-NAFLD activity score in the group as a whole (p < 0.001) with no difference detected between subgroups (p = 0.31). Our results confirm that lifestyle modification is effective in improving NAFLD and NASH. Conclusions: Regardless of intervention group, lifestyle modification improved liver histology, as verified by repeat biopsy, after a 6-month intervention. This study reinforces the importance of lifestyle modification as the primary treatment strategy for patients with NAFLD. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. [Eckard, Carly] Vicenza Hlth Ctr, US Army Med Dept, Vicenza, Italy. [Cole, Renee] Army Med Dept Ctr & Sch, US Mil Dietet Internship, Ft Sam Houston, TX USA. [Lockwood, Joshua] Womack Army Med Ctr, Nutr Care Div, Ft Bragg, NC USA. [Torres, Dawn M.] Walter Reed Army Med Ctr, Dept Med, Hepatol Clin, Gastroenterol Serv, Washington, DC 20307 USA. [Williams, Christopher D.] Brooke Army Med Ctr, Gastroenterol Serv, Dept Med, Ft Sam Houston, TX 78234 USA. [Shaw, Janet C.] Wilford Hall USAF Med Ctr, Lackland AFB, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 48 TC 29 Z9 31 U1 1 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1756-283X EI 1756-2848 J9 THER ADV GASTROENTER JI Ther. Adv. Gastroenterol. PD JUL PY 2013 VL 6 IS 4 BP 249 EP 259 DI 10.1177/1756283X13484078 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AG9OE UT WOS:000335748200001 PM 23814606 ER PT J AU Getz, TM Stefanini, L Piatt, R Paul, D Cholka, A Walton, BL Wolberg, AS White, GC Bergmeier, W AF Getz, T. M. Stefanini, L. Piatt, R. Paul, D. Cholka, A. Walton, B. L. Wolberg, A. S. White, G. C., III Bergmeier, W. TI Rap signaling is central to the pro-adhesive and pro-coagulant platelet response SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 [Getz, T. M.; Stefanini, L.; Piatt, R.; Paul, D.; Cholka, A.; Walton, B. L.; Wolberg, A. S.; Bergmeier, W.] UNC, Chapel Hill, NC USA. [White, G. C., III] USA, Blood Res Inst Milwaukee, Milwaukee, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JUL PY 2013 VL 11 SU 2 SI SI BP 137 EP 137 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA AB5MV UT WOS:000331833601309 ER PT J AU Takahashi, MD Abershitz, A Rubinets, R Whalley, MS AF Takahashi, Marc D. Abershitz, Avi Rubinets, Rafael Whalley, Matthew S. TI Evaluation of Safe Landing Area Determination Algorithms for Autonomous Rotorcraft Using Site Benchmarking SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB An important element of rotorcraft UAV operations is safe landing area determination (SLAD), which is the ability to select desirable landing or load placement areas at unprepared sites. Effectively and reliably accomplishing this task would greatly enhance high-level autonomous capabilities in many operations such as search and rescue and resupply. This paper presents the results of quantitatively evaluating two SLAD algorithms using a new test method that incorporates a detailed survey of the test sites. These survey sites act as benchmarks against which the SLAD methods are compared. One SLAD algorithm is a new approach that uses laser range data to detect a set of potential landing points and uses fuzzy logic to rank them based on surface roughness, size, and terrain slope metrics. The second algorithm uses laser range data to optimize a performance index, based on sliding window statistics of surface slope and roughness over the landing zone, to select potential landing points. Flight-test data were collected at six sites ranging from simple to complex with multiple runs at each site. Both methods are evaluated based on their true-positive and false-positive rates and the consistency of their landing site selection. C1 [Takahashi, Marc D.; Whalley, Matthew S.] US Army Res Dev & Engn Command, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. [Abershitz, Avi; Rubinets, Rafael] Israel Aerosp Ind, Div Engn, Ben Gurion, LOD, Israel. RP Takahashi, MD (reprint author), US Army Res Dev & Engn Command, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. EM marc.d.takahashi.civ@mail.mil NR 17 TC 2 Z9 2 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2013 VL 58 IS 3 AR 032007 DI 10.4050/JAHS.58.032007 PG 13 WC Engineering, Aerospace SC Engineering GA AB5MW UT WOS:000331833700007 ER PT J AU Tieu, HV Rolland, M Hammer, SM Sobieszczyk, ME AF Hong-Van Tieu Rolland, Morgane Hammer, Scott M. Sobieszczyk, Magdalena E. TI Translational Research Insights From Completed HIV Vaccine Efficacy Trials SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV vaccine; efficacy trials; clinical trials; vaccine design ID IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMBINANT GLYCOPROTEIN-120 VACCINE; BROADLY NEUTRALIZING ANTIBODIES; DOUBLE-BLIND; HIV-1-INFECTED INDIVIDUALS; ANTIRETROVIRAL THERAPY; MONOCLONAL-ANTIBODIES; FOUNDER VIRUS; INFECTION; ESCAPE AB The development of a safe and effective HIV vaccine remains a challenge. The modest efficacy seen in the RV144 vaccine trial represented an important milestone for the field. Results from all efficacy studies done to date have generated new information, which has advanced the HIV vaccine field in important ways. In this article, we review the translational research insights from the vaccine efficacy trials completed and fully analyzed to date. We also describe the recent advances in the search for broadly neutralizing antibodies and discuss potential approaches to circumvent the challenge posed by the enormous diversity of HIV-1. The experience from the past 5 years highlights the importance of conducting efficacy studies that continue to move us closer toward the goal of a safe, effective, durable, and universal HIV preventive vaccine. C1 [Hong-Van Tieu] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. [Hong-Van Tieu; Hammer, Scott M.; Sobieszczyk, Magdalena E.] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA. [Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Rolland, Morgane] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Sobieszczyk, ME (reprint author), Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, 630 W 168th St,Box 82, New York, NY 10032 USA. EM mes52@columbia.edu FU NIH [K01 DA031035]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0 174]; US Department of Defense (DoD) [W81XWH-11-2-0 174]; US Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases; NIH/NIAID [U01-AI069470]; Columbia University's CTSA from the National Center for Advancing Translational Sciences, NIH [UL1TR000040] FX H-V.T. is supported by NIH K01 DA031035. Funding to M. R. is provided by a cooperative agreement (W81XWH-11-2-0 174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DoD); and by an Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research and Material Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. S. H. and M. S. are supported by grant (U01-AI069470) from NIH/NIAID, and this work was supported in part by Columbia University's CTSA grant No. UL1TR000040 from the National Center for Advancing Translational Sciences, NIH. Opinions expressed herein are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense. NR 69 TC 3 Z9 4 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUL 1 PY 2013 VL 63 SU 2 BP S150 EP S154 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 300JD UT WOS:000330459300008 PM 23764628 ER PT J AU Wiechman, S Meyer, W Edelman, L Fauerbach, J Gibbons, L Holavanahalli, R Hunt, C Keller, K Kirk, E Laird, J Lewis, G Moses, S Sproul, J Wilkinson, G Wolf, S Young, A Yovino, S AF Wiechman, Shelley Meyer, Walter Edelman, Linda Fauerbach, Jim Gibbons, Linda Holavanahalli, Radha Hunt, Carly Keller, Kelly Kirk, Elizabeth Laird, Jacqueline Lewis, Giavonni Moses, Sidonie Sproul, Jill Wilkinson, Gretta Wolf, Steve Young, Alan Yovino, Sandra TI Psychological Outcomes SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; BURN INJURY; MORBIDITY; CHILDREN C1 [Wiechman, Shelley] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. [Meyer, Walter] Univ Texas Med Branch, Galveston, TX 77555 USA. [Edelman, Linda; Lewis, Giavonni] Univ Utah, Salt Lake City, UT USA. [Fauerbach, Jim; Hunt, Carly] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Holavanahalli, Radha; Wolf, Steve] Univ Texas Southwestern, Dallas, TX USA. [Keller, Kelly] Ohio State Univ, Med Ctr, Mansfield, PA USA. [Kirk, Elizabeth] Arkansas Childrens Hosp, Little Rock, AR 72202 USA. [Laird, Jacqueline] Bridgeport Hosp, Bridgeport, CT USA. [Moses, Sidonie] Univ Kansas Hosp, Kansas City, KS USA. [Sproul, Jill] Santa Clara Valley Med Ctr, San Jose, CA 95128 USA. [Young, Alan] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Yovino, Sandra] Leon S Peters Burn Ctr, Fresno, CA USA. RP Wiechman, S (reprint author), Univ Washington, Harborview Med Ctr, Burn Ctr, 325 Ninth Ave,Box 359740, Seattle, WA 98104 USA. NR 21 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2013 VL 34 IS 4 BP 363 EP 368 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 300LD UT WOS:000330464500014 ER PT J AU Mosier, MJ Cancio, LC Amani, H Blayney, C Cullinane, J Haith, L Jeng, JC Kardos, P Kramer, G Lawless, MB Serio-Melvin, ML Miller, S Moran, K Novakovic, R Potenza, B Rinewalt, A Schultz, J Smith, H AF Mosier, Michael J. Cancio, Leopoldo C. Amani, Hamed Blayney, Carolyn Cullinane, Judith Haith, Linwood Jeng, James C. Kardos, Patricia Kramer, George Lawless, Mary Beth Serio-Melvin, Maria L. Miller, Sidney Moran, Katie Novakovic, Rachel Potenza, Bruce Rinewalt, Anna Schultz, John Smith, Howard TI Burn Resuscitation SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID MILITARY CASUALTIES; FLUID CREEP; OUTCOMES; FORMULA; VOLUMES; INJURY C1 [Mosier, Michael J.] Loyola Univ, Med Ctr, Loyola Burn Ctr, Dept Surg, Maywood, IL 60153 USA. [Cancio, Leopoldo C.; Serio-Melvin, Maria L.; Schultz, John] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Amani, Hamed] Lehigh Valley, Allentown, PA USA. [Blayney, Carolyn] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. [Cullinane, Judith; Miller, Sidney] Shriners Hosp Children, Boston, MA USA. [Haith, Linwood] Nathan Speare Reg Burn Treatment Ctr, Upland, PA USA. [Jeng, James C.] Washington Hosp, Burn Ctr, Washington, DC USA. [Kardos, Patricia] Arizona Burn Ctr, Phoenix, AZ USA. [Kramer, George] Univ Texas Med Branch, Galveston, TX 77555 USA. [Lawless, Mary Beth] Univ Calif Davis, Reg Burn Ctr, Sacramento, CA 95817 USA. Ohio State Med Ctr, Columbus, OH USA. [Moran, Katie] Bridgeport Hosp, Bridgeport, CT USA. [Novakovic, Rachel] Mercy St Vincent Med Ctr, Toledo, OH USA. [Potenza, Bruce] Univ Calif San Diego, Reg Burn Ctr, La Jolla, CA 92093 USA. [Rinewalt, Anna] Arkansas Childrens Hosp, Little Rock, AR 72202 USA. [Smith, Howard] Orlando Reg Healthcare Syst, Orlando, FL USA. RP Mosier, MJ (reprint author), Loyola Univ, Med Ctr, 2160 S 1st Ave, Maywood, IL 60153 USA. NR 13 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2013 VL 34 IS 4 BP 368 EP 371 PG 4 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 300LD UT WOS:000330464500015 ER PT J AU Ho, PC Nguyen, ME Golden, PJ AF Ho, Paul C. Nguyen, Marie E. Golden, Patrick J. TI Percutaneous Temporary Aortic Valve: A Proof-of-Concept Animal Model SO JOURNAL OF HEART VALVE DISEASE LA English DT Article ID CORONARY-ARTERY; BLOOD-FLOW; REPLACEMENT; REGURGITATION; IMPLANTATION; DELIVERY; SYSTEM AB Background and aim of the study: An early prototype of a temporary aortic valve (TAV) catheter system was evaluated for its potential to serve as an integrated device for aortic valve intervention and replacement. The prototype consisted of two essential components: a central catheter for the delivery of aortic valve interventional tools (valve debulking, resection, replacement); and a balloon-inflatable temporary valve for hemodynamic support when the native aortic valve is removed. After valve replacement, the TAV catheter system is designed to be readily withdrawn from the subject. Methods: Individual aspects of both components of the prototype were examined in experiments with four pigs. The central catheter was used to deliver a self-expanding stent for native aortic valve ablation to create acute severe aortic insufficiency (AI). The balloon-TAV was deployed in the proximal aorta to control the induced AI. Electrocardiographic (ECG), cardiac output (CO), pulmonary wedge pressure (PWP), left ventricular (LV) pressure, and aortic pressure proximal and distal from the TAV were recorded. Results: The central catheter was successful in delivering and deploying the valve ablation stent at the annulus to create massive AI the LV diastolic pressure was increased from 12.6 +/- 1.1 to 32.4 +/- 2.0 mmHg (p <0.001) with valve ablation. The deployed TAV in the proximal aorta led to a re-narrowing of the distal pulse pressure with a drop in the LV diastolic pressure to 21.5 +/- 1.5 mmHg (p <0.001). During TAV support, some PWP lowering and a CO rise occurred, but these did not achieve statistical significance; no significant acute ECG changes were noted. Conclusion: In this early prototype, the TAV catheter system demonstrated the potential to serve as an integrated device for both aortic valve modification and replacement. C1 [Ho, Paul C.; Nguyen, Marie E.] HOCOR Cardiovascu Technol LLC, Honolulu, HI 96814 USA. [Golden, Patrick J.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Ho, PC (reprint author), HOCOR Cardiovascu Technol LLC, 88 Piikoi St,Suite 3903, Honolulu, HI 96814 USA. EM hocor@mac.com NR 16 TC 0 Z9 1 U1 0 U2 1 PU I C R PUBLISHERS PI NORTHWOOD PA CRISPIN HOUSE, 12/A SOUTH APPROACH, MOOR PARK, NORTHWOOD HA6 2ET, ENGLAND SN 0966-8519 J9 J HEART VALVE DIS JI J. Heart Valve Dis. PD JUL PY 2013 VL 22 IS 4 BP 460 EP 467 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 303OE UT WOS:000330683000003 PM 24224407 ER PT J AU Gallaway, MS Fink, DS Millikan, AM Mitchell, MM Bell, MR AF Gallaway, Michael Shayne Fink, David S. Millikan, Amy M. Mitchell, Mary M. Bell, Michael R. TI The Association Between Combat Exposure and Negative Behavioral and Psychiatric Conditions SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Deployment; combat exposure; behavioral health; military ID POSTTRAUMATIC-STRESS-DISORDER; OPERATION IRAQI FREEDOM; MENTAL-HEALTH PROBLEMS; RISK-FACTORS; AFGHANISTAN; POPULATION; DEPLOYMENT; VETERANS; CARE; SYMPTOMS AB This study evaluated the association between cumulative combat exposures and negative behavioral and psychiatric conditions. A total of 6128 active-duty soldiers completed a survey approximately 6 months after their unit's most recent combat deployment. The soldiers self-reported combat exposures and behavioral and psychiatric conditions. Multivariable logistic regression was used to assess the association between cumulative combat exposures and behavioral and psychiatric outcomes. In comparison with the referent group of soldiers not previously deployed, the soldiers categorized as having the highest cumulative combat exposures were significantly associated with self-reporting a history of behavioral and psychiatric diagnoses, problematic alcohol misuse, aggression, criminal behavior, and physical altercations with a significant other. The magnitude and the consistency of the association among the soldiers with the highest number of combat exposures suggest that the number of cumulative combat deployment exposures is an important consideration for identifying and treating high-risk soldiers and units returning from combat. C1 [Gallaway, Michael Shayne; Fink, David S.; Millikan, Amy M.; Mitchell, Mary M.] US Army Publ Hlth Command, Behav & Social Hlth Outcomes Program BSHOP, US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gallaway, MS (reprint author), 5158 Blackhawk Rd, Aberdeen, MD 21010 USA. EM michael.s.gallaway.civ@mail.mil OI Fink, David/0000-0003-1531-1525 NR 32 TC 10 Z9 10 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 EI 1539-736X J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JUL PY 2013 VL 201 IS 7 BP 572 EP 578 DI 10.1097/NMD.0b013e318298296a PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 299CA UT WOS:000330371300006 PM 23817154 ER PT J AU Scott, DJ Eliason, JL Villamaria, C Morrison, JJ Houston, R Spencer, JR Rasmussen, TE AF Scott, Daniel J. Eliason, Jonathan L. Villamaria, Carole Morrison, Jonathan J. Houston, Robert Spencer, Jerry R. Rasmussen, Todd E. TI A novel fluoroscopy-free, resuscitative endovascular aortic balloon occlusion system in a model of hemorrhagic shock SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Endovascular occlusion of aorta; hemorrhagic shock; swine ID NONCOMPRESSIBLE TORSO HEMORRHAGE; COMBAT CASUALTY CARE; TRAUMA CENTER; DEATH AB BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potentially lifesaving maneuver in the setting of hemorrhagic shock. However, emergent use of REBOA is limited by existing technology, which requires large sheath arterial access and fluoroscopy-guided balloon positioning. The objectives of this study were to describe a new, fluoroscopy-free REBOA system and to compare its efficacy to existing technology. An additional objective was to characterize the survivability of 60 minutes of REBOA using these systems in a model of hemorrhagic shock. METHODS: Swine (70-88 kg) in shock underwent 60 minutes of REBOA using either a self-centering, one component prototype balloon system (PBS, n = 8) inserted (8 Fr) and inflated without fluoroscopy or a two-component, commercially available balloon system (CBS, n = 8) inserted (14 Fr) with fluoroscopic guidance. Following REBOA, resuscitation occurred for 48 hours with blood, crystalloid, and vasopressors. End points included accurate balloon positioning, hemodynamics, markers of ischemia, resuscitation requirements, and mortality. RESULTS: Posthemorrhage mean arterial pressure (mm Hg) was similar in the CBS and PBS groups (35 [8] vs. 34 [5]; p = 0.89). Accurate balloon positioning and inflation occurred in 100% of the CBS and 88% of the PBS group. Following REBOA, mean arterial pressure increased comparably in the CBS and PBS groups (81 [20] vs. 89 [16]; p = 0.21). Lactate peaked in the CBS and PBS groups (10.8 [1.4] mmol/L vs. 13.2 [2.1] mmol/L; p = 0.01) 45 minutes following balloon deflation but returned to baseline by 24 hours. Mortality was similar between the CBS and PBS groups (12% vs. 25%, p = 0.50). CONCLUSION: This study reports the feasibility and efficacy of a novel, fluoroscopy-free REBOA system in a model of shock. Despite a significant physiologic insult, 60 minutes of REBOA is tolerated and recoverable. Development of lower profile, fluoroscopy-free endovascular balloon occlusion catheters may allow proactive aortic control in patients at risk for hemorrhagic shock and cardiovascular collapse. (J Trauma Acute Care Surg. 2013; 75: 122-128. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Scott, Daniel J.; Villamaria, Carole; Houston, Robert; Spencer, Jerry R.; Rasmussen, Todd E.] 59th Med Wing, Lackland AFB, TX USA. [Scott, Daniel J.; Villamaria, Carole; Morrison, Jonathan J.; Houston, Robert; Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX 78236 USA. [Eliason, Jonathan L.] Univ Michigan, Vasc Surg Sect, Ann Arbor, MI 48109 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. RP Rasmussen, TE (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78236 USA. EM todd.e.rasmussen.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 15 TC 34 Z9 34 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUL PY 2013 VL 75 IS 1 BP 122 EP 128 DI 10.1097/TA.0b013e3182946746 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300EV UT WOS:000330448100033 PM 23940855 ER PT J AU Kheirabadi, BS Terrazas, IB Koller, A Allen, PB Klemcke, HG Convertino, VA Dubick, MA Gerhardt, RT Blackbourne, LH AF Kheirabadi, Bijan S. Terrazas, Irasema B. Koller, Alexandra Allen, Paul B. Klemcke, Harold G. Convertino, Victor A. Dubick, Michael A. Gerhardt, Robert T. Blackbourne, Lorne H. TI Vented versus unvented chest seals for treatment of pneumothorax and prevention of tension pneumothorax in a swine model SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Pneumothorax; chest seals; tension pneumothorax; combat casualty care; swine ID COMBAT CASUALTIES AB BACKGROUND: Unvented chest seals (CSs) are currently recommended for the management of penetrating thoracic injuries in the battlefield. Since no supporting data exist, we compared the efficacy of a preferred unvented with that of a vented CS in a novel swine model of pneumothorax (PTx). METHODS: An open chest wound was created in the left thorax of spontaneously air-breathing anesthetized pigs (n = 8). A CS was applied over the injury, then tension PTx was induced by incremental air injections (0.2 L) into the pleural cavity via a cannula that was also used to measure intrapleural pressure (IP). Both CS were tested on each pig in series. Tidal volume (V-T), respiratory rate, IP, heart rate, mean arterial pressure, cardiac output, central venous pressure, pulmonary arterial pressure, venous and peripheral oxygen saturations (SvO(2), SpO(2)) were recorded. Tension PTx was defined as a mean IP equal to or greater than + 1 mm Hg plus significant (20-30%) deviation in baseline levels of the previously mentioned parameters and confirmed by chest x-ray study. PaO2 and PaCo2 were also measured. RESULTS: PTx produced immediate breathing difficulty and significant rises in IP and pulmonary arterial pressure and falls in V-T, SpO(2), and SvO(2). Both CSs returned these parameters to near baseline within 5 minutes of application. After vented CS was applied, serial air injections up to 2 L resulted in no significant change in the previously mentioned parameters. After unvented CS application, progressive deterioration of all respiratory parameters and onset of tension PTx were observed in all subjects after approximately 1.4-L air injection. CONCLUSION: Both vented and unvented CSs provided immediate improvements in breathing and blood oxygenation in our model of penetrating thoracic trauma. However, in the presence of ongoing intrapleural air accumulation, the unvented CS led to tension PTx, hypoxemia, and possible respiratory arrest, while the vented CS prevented these outcomes. (J Trauma Acute Care Surg. 2013; 75: 150-156. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Koller, Alexandra; Allen, Paul B.; Klemcke, Harold G.; Convertino, Victor A.; Dubick, Michael A.; Gerhardt, Robert T.; Blackbourne, Lorne H.] US Army Inst Surg Res, San Antonio, TX USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM Bijan.S.Kheirabadi.civ@mail.mil FU US Army Medical Research and Materiel Command FX The funding for this work was provided solely by the US Army Medical Research and Materiel Command. NR 14 TC 10 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUL PY 2013 VL 75 IS 1 BP 150 EP 156 DI 10.1097/TA.0b013e3182988afe PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300EV UT WOS:000330448100038 PM 23940861 ER PT J AU Bristow, EC Brumbelow, K AF Bristow, Elizabeth C. Brumbelow, Kelly TI Simulation to Aid Disaster Planning and Mitigation: Tools and Techniques for Water Distribution Managers and Emergency Planners SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Critical infrastructure; Infrastructure failure; Urban fire response; Water distribution system; Emergency planning ID INFRASTRUCTURE SYSTEMS AB Communities depend on increasingly complex critical infrastructures to meet residents' daily needs and to facilitate emergency response. The potential for cascading failures could intensify the consequences of disasters and complicate the process of planning for effective emergency response. This article presents a methodology for conducting a vulnerability analysis based on simulation of water distribution's role in emergency response under various complex-disaster scenarios in which incapacity of the water system is coupled with an urban fire. The analysis reported here was run on a virtual (but detailed and realistic) small-town water distribution system to permit candid discussion of the insights derived from the vulnerability analysis and to avoid disclosing the vulnerabilities of a real system. The analysis methodology presented may be adapted to fit the needs of real communities. The results of these simulations are used to demonstrate a procedure for designing and testing mitigation methods to improve the community's robustness and resiliency. Most of the mitigation techniques involve infrastructure upgrades, and a cost-benefit analysis of these approaches is included as an aid to decision making. Discussion of how utility managers and emergency planners may adapt the analysis technique to their own systems is included throughout. (C) 2013 American Society of Civil Engineers. C1 [Bristow, Elizabeth C.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Brumbelow, Kelly] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. RP Bristow, EC (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM elizabeth.bristow@usma.edu; kbrumbelow@civil.tamu.edu FU National Science Foundation [CMS-0600448]; DOE [DE-AC05-00OR22750] FX This article is based upon work supported by the National Science Foundation under Grant No. CMS-0600448.; This research was performed while the first author was on appointment as a U.S. Department of Homeland Security (DHS) Fellow under the DHS Scholarship and Fellowship Program, a program administered by the Oak Ridge Institute for Science and Education (ORISE) for DHS through an interagency agreement with the U.S Department of Energy (DOE). ORISE is managed by Oak Ridge Associated Universities under DOE contract number DE-AC05-00OR22750. All opinions expressed in this paper are the authors' and do not necessarily reflect the policies and views of DHS, DOE, or ORISE. NR 32 TC 1 Z9 1 U1 1 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PL JI J. Water Resour. Plan. Manage.-ASCE PD JUL PY 2013 VL 139 IS 4 BP 376 EP 386 DI 10.1061/(ASCE)WR.1943-5452.0000283 PG 11 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 301FK UT WOS:000330518000003 ER PT J AU Roy, TC Lopez, HP Piva, SR AF Roy, Tanja C. Lopez, Heather P. Piva, Sara R. TI Loads Worn by Soldiers Predict Episodes of Low Back Pain During Deployment to Afghanistan SO SPINE LA English DT Article DE low back pain; US Army; risk factors; occupational factors; deployment ID OPERATIONS IRAQI FREEDOM; BRIGADE COMBAT TEAM; RISK-FACTORS; ENDURING FREEDOM; PHYSICAL THERAPIST; OUTPATIENT VISITS; NONBATTLE INJURY; ROAD MARCH; US ARMY; PERFORMANCE AB Study Design. Prospective cohort study. Objective. To describe low back pain (LBP) sustained by soldiers deployed to Afghanistan and identify demographic, fitness, and occupational risk factors of LBP. Summary of Background Data. LBP is the most common injury in deployed soldiers. It results in lost duty days, medical evacuations, and permanent disability. Risk factors for LBP have not been investigated in this population. Methods. This study investigated a US Army Brigade Combat Team deployed to Afghanistan for 1 year. Demographic, fitness, and occupational variables were recorded before and after deployment. Episodes of LBP were assessed using self-report data. Logistic regression was used to investigate predictors of (1) moderate or worse LBP developed during deployment and (2) all LBP developed during deployment. Results. The incidence of moderate or worse LBP was 22% in the 805 soldiers studied. Soldiers with elevated risk of LBP were male, in Cavalry or Infantry units, wore body armor for more than 6 hr/d, worked at a desk for 1 to 4 hours a day, spent 5 to 8 hr/d lifting, spent more than 1 hr/wk on walking patrol, spent 21 to 40 hr/wk in a tactical vehicle, or wore equipment. The most parsimonious set of significant predictors for moderate or worse LBP included age, OR = 1.04 (1.01-1.08); fitness score, OR = 0.99 (0.989-0.999); the amount of time spent wearing body armor, OR = 1.16 (1.10-1.23); the amount of time spent on walking patrol, OR = 1.01 (1.003-1.02); and weight of the equipment worn, OR = 1.01 (1.002-1.013). The incidence of all LBP (minor or worse) was 77%. The most parsimonious set of significant predictors for all LBP included age, OR = 1.06 (1.02-1.09); fitness score, OR = 0.99 (0.985-0.997); history of LBP, OR = 2.94, (1.87-4.62); equipment weight, OR = 1.008 (1.003-1.01); and time spent wearing body armor, OR = 1.13 (1.07-1.19). Conclusion. This study found that being older, having lower fitness scores, wearing armor longer, and wearing heavier loads increased the risk of LBP in deployed soldiers. Units more likely to wear loads such as the Infantry and Cavalry and tasks commonly involving wearing loads such as patrolling all increased the risk of LBP as well. C1 [Roy, Tanja C.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Lopez, Heather P.] 101st Airborne Div Air Assault, Brigade Combat Team 2, Ft Campbell, KY USA. [Piva, Sara R.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Phys Therapy Dept, Pittsburgh, PA USA. RP Roy, TC (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, Bldg 42,15 Kansas St, Natick, MA 01760 USA. EM tanja.roy@us.army.mil FU US Army Institute of Environmental Medicine FX Funding was provided by US Army Institute of Environmental Medicine under Task Area S. NR 53 TC 7 Z9 8 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 EI 1528-1159 J9 SPINE JI SPINE PD JUL 1 PY 2013 VL 38 IS 15 BP 1310 EP 1317 DI 10.1097/BRS.0b013e31829265c4 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 298XR UT WOS:000330358500021 PM 23532119 ER PT J AU Phillips, FM Lee, JYB Geisler, FH Cappuccino, A Chaput, CD DeVine, JG Reah, C Gilder, KM Howell, KM McAfee, PC AF Phillips, Frank M. Lee, Joe Y. B. Geisler, Fred H. Cappuccino, Andrew Chaput, Christopher D. DeVine, John G. Reah, Christopher Gilder, Kye M. Howell, Kelli M. McAfee, Paul C. TI A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM Cervical Disc Arthroplasty With Anterior Cervical Discectomy and Fusion 2-Year Results From the US FDA IDE Clinical Trial SO SPINE LA English DT Article DE cervical total disc replacement; Porous Coated Motion; PCM; ACDF; arthroplasty; randomized clinical trial ID TERM-FOLLOW-UP; INTERBODY FUSION; INTERVERTEBRAL DISCS; INTRADISCAL PRESSURE; DEVICE EXEMPTION; ADJACENT; ARTHRODESIS; SPINE; DISEASE; REPLACEMENT AB Study Design. Prospective, multicenter, randomized Food and Drug Administration approved investigational device exemption clinical trial. Objective. To evaluate the safety and effectiveness of the PCM Cervical Disc compared with anterior cervical discectomy and fusion (ACDF) in the treatment of patients with degenerative spondylosis and neurological symptoms at 1 level between C3-C4 and C7-T1. Summary of Background Data. Cervical disc arthroplasty in the treatment of symptomatic cervical spondylosis has been studied in other series. The PCM Cervical Disc is a nonconstrained motion-sparing alternative to ACDF. Methods. Patients 18 to 65 years of age with single-level symptomatic cervical spondylosis with radiculopathy and/or myelopathy unresponsive to nonoperative treatment were enrolled, including patients with prior nonadjacent or adjacent single-level fusions. The per-protocol patient sample at 2 years included 342 patients (189 PCM, 153 ACDF). Longitudinal outcomes were comparatively evaluated. Results. At 2 years postoperatively, clinical measures-neck and arm pain visual analogue scale, Neck Disability Index (NDI), SF-36, and neurological status-were significantly improved from preoperative baselines in both groups. Mean NDI score at 2 years was significantly lower in PCM group (P = 0.029). There were no statistical differences between groups in rates of surgery-related serious adverse events (5.6% PCM, 7.4% ACDF) or secondary surgical procedures (5.2% PCM, 5.4% ACDF). Patients with PCM reported lower dysphagia scores (8.8/100 vs. 12.1/100; P = 0.045) and higher patient satisfaction (82.8/100 vs. 81.4/100). Overall success, a composite endpoint including minimum 20% NDI improvement, no major complications, no neurological worsening, no secondary surgical procedures, and meeting radiographical criteria of motion for PCM and fusion for ACDF, was significantly greater in the PCM group (75.1% vs. 64.9%; P = 0.020). Conclusion. The treatment of symptomatic single-level cervical spondylosis with PCM achieves clinical outcomes that are at least equivalent to ACDF while maintaining motion. At 2 years, patients with PCM had lower NDI scores, statistically lower rate of prolonged dysphagia, greater patient satisfaction, and superior overall success. C1 [Phillips, Frank M.; Lee, Joe Y. B.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Geisler, Fred H.] Chicago Back Inst, Chicago, IL USA. [Cappuccino, Andrew] Buffalo Spine Surg, Buffalo, NY USA. [Chaput, Christopher D.] Scott & White Hosp, Temple, TX USA. [DeVine, John G.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Reah, Christopher; Gilder, Kye M.; Howell, Kelli M.] NuVasive Inc, San Diego, CA USA. [McAfee, Paul C.] St Josephs Hosp, Baltimore, MD USA. RP Phillips, FM (reprint author), Rush Univ, Med Ctr, 1611 W Harrison St,Ste 300, Chicago, IL 60612 USA. EM fphillips@rushortho.com FU NuVasive, Inc. funds FX NuVasive, Inc. funds were received to support this work. NR 52 TC 43 Z9 46 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0362-2436 EI 1528-1159 J9 SPINE JI SPINE PD JUL 1 PY 2013 VL 38 IS 15 BP E907 EP E918 DI 10.1097/BRS.0b013e318296232f PG 12 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 298XR UT WOS:000330358500001 PM 23591659 ER PT J AU Apodaca, AN Morrison, JJ Spott, MA Lira, JJ Bailey, J Eastridge, BJ Mabry, RL AF Apodaca, Amy N. Morrison, Jonathan J. Spott, Mary Ann Lira, John J. Bailey, Jeffery Eastridge, Brian J. Mabry, Robert L. TI IMPROVEMENTS IN THE HEMODYNAMIC STABILITY OF COMBAT CASUALTIES DURING EN ROUTE CARE SO SHOCK LA English DT Article DE Shock; hemorrhage; resuscitation; prehospital care; combat casualty care ID PREHOSPITAL SHOCK INDEX; CENTRAL VENOUS OXIMETRY; TRANEXAMIC ACID; CLINICAL SHOCK; EMERGENCY; MORTALITY; UTILITY; WOUNDS; INJURY AB Three Forward Aeromedical Evacuation platforms operate in Southern Afghanistan: UK Medical Emergency Response Team (MERT), US Air Force Expeditionary Rescue Squadron (PEDRO), and US Army Medical Evacuation Squadrons (DUSTOFF), each with a different clinical capability. Recent evidence suggests that retrieval by a platform with a greater clinical capability (MERT) is associated with improved mortality in critical patients when compared with platforms with less clinical capability (PEDRO and DUSTOFF). It is unclear whether this is due to en route resuscitation or the dispatch procedure. The aim of this study was to compare prehospital Shock Index (SI = heart rate / systolic blood pressure) with admission values as a measure of resuscitation, across these platforms. Patients were identified from the Department of Defense Trauma Registry, who were evacuated between June 2009 and June 2011 in Southern Afghanistan. Data on platform type, physiology, and injury severity was extracted. Overall, 865 patients were identified: 478 MERT, 291 PEDRO, and 96 DUSTOFF patients and groups were compared across three injury severity scoring (ISS) bins: 1 to 9, 10 to 25, and 26 or greater. An improvement in the admission SI was observed across all platforms in the lowest ISS bin. Within the middle bin, both the MERT and PEDRO groups saw improved SI on admission, but not the DUSTOFF group. This trend was continued only in the MERT group for the highest ISS bin (1.39 +/- 0.62 vs. 1.09 +/- 0.42; P = 0.001), whereas a deterioration was identified in the PEDRO group (0.88 +/- 0.37 vs. 1.02 +/- 0.43; P = 0.440). The use of a Forward Aeromedical Evacuation platform with a greater clinical capability is associated with an improved hemodynamic status in critical casualties. The ideal prehospital triage should endeavor to match patient need with clinical capability. C1 [Apodaca, Amy N.; Spott, Mary Ann; Lira, John J.; Bailey, Jeffery; Eastridge, Brian J.; Mabry, Robert L.] US Army Inst Surg Res, Joint Trauma Syst, San Antonio, TX 78234 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. RP Apodaca, AN (reprint author), US Army Inst Surg Res, Joint Trauma Syst, San Antonio, TX 78234 USA. EM amy.n.apodaca.ctr@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 25 TC 12 Z9 12 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUL PY 2013 VL 40 IS 1 BP 5 EP 10 DI 10.1097/SHK.0b013e31829793d7 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297GM UT WOS:000330243800002 PM 23635851 ER PT J AU Darlington, DN Cap, AP Dubick, MA AF Darlington, Daniel N. Cap, Andrew P. Dubick, Michael A. TI Acute Coagulopathy of Trauma in the Rat. Shock 39:440-446, 2013. Reply SO SHOCK LA English DT Letter ID PROTHROMBIN TIME; HYPOTHERMIA; ACIDOSIS; THROMBOELASTOGRAPHY; THROMBELASTOGRAPHY; HYPOPERFUSION C1 [Darlington, Daniel N.; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, San Antonio, TX USA. RP Darlington, DN (reprint author), US Army Inst Surg Res, San Antonio, TX USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUL PY 2013 VL 40 IS 1 BP 74 EP 75 PG 3 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297GM UT WOS:000330243800013 PM 23770765 ER PT J AU Contreras, U Li, GB Foster, CD Shabana, AA Jayakumar, P Letherwood, MD AF Contreras, Ulysses Li, Guangbu Foster, Craig D. Shabana, Ahmed A. Jayakumar, Paramsothy Letherwood, Michael D. TI Soil Models and Vehicle System Dynamics SO APPLIED MECHANICS REVIEWS LA English DT Review DE soil mechanics; finite element; multibody systems; terramechanics ID FINITE-ELEMENT-ANALYSIS; VISCOPLASTIC CAP MODEL; CONSTITUTIVE MODEL; TRACTIVE PERFORMANCE; MULTIBODY DYNAMICS; LARGE-DEFORMATION; TRACKED VEHICLES; SOFT SOIL; TIRE; SIMULATION AB The mechanical behavior of soils may be approximated using different models that depend on particular soil characteristics and simplifying assumptions. For this reason, researchers have proposed and expounded upon a large number of constitutive models and approaches that describe various aspects of soil behavior. However, there are few material models capable of predicting the behavior of soils for engineering applications and are at the same time appropriate for implementation into finite element (FE) and multibody system (MBS) algorithms. This paper presents a survey of some of the commonly used continuum-based soil models. The aim is to provide a summary of continuum-based soil models and examine their suitability for integration with the large-displacement FE absolute nodal coordinate formulation (ANCF) and MBS algorithms. Special emphasis is placed on the formulation of soils used in conjunction with vehicle dynamics models. The implementation of these soil models in MBS algorithms used in the analysis of complex vehicle systems is also discussed. Because semiempirical terramechanics soil models are currently the most widely used to study vehicle/soil interaction, a review of classical terramechanics models is presented in order to be able to explain the modes of displacements that are not captured by these simpler models. Other methods such as the particle-based and mesh-free models are also briefly reviewed. A Cam-Clay soil model is used in this paper to explain how such continuum-mechanics based soil models can be implemented in FE/MBS algorithms. C1 [Contreras, Ulysses; Shabana, Ahmed A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. [Li, Guangbu] Shanghai Normal Univ, Dept Mech Engn, Shanghai 200234, Peoples R China. [Foster, Craig D.] Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60607 USA. [Jayakumar, Paramsothy; Letherwood, Michael D.] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Contreras, U (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 West Taylor St, Chicago, IL 60607 USA. FU US Army Tank-Automotive Research, Development, and Engineering Center (TARDEC) [W911NF-07-D-0001] FX This research was supported by the US Army Tank-Automotive Research, Development, and Engineering Center (TARDEC) (Contract No. W911NF-07-D-0001). NR 120 TC 1 Z9 1 U1 3 U2 30 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0003-6900 J9 APPL MECH REV JI Appl. Mech. Rev. PD JUL PY 2013 VL 65 IS 4 AR 041001 DI 10.1115/1.4024759 PG 21 WC Mechanics SC Mechanics GA 288LB UT WOS:000329612400002 ER PT J AU Xydakis, MS Ling, GSF Mulligan, LP Dorlac, WC Hack, DC AF Xydakis, Michael S. Ling, Geoffrey S. F. Mulligan, Lisa P. Dorlac, Warren C. Hack, Dallas C. TI Loss of Consciousness and Concussion Reply SO ANNALS OF NEUROLOGY LA English DT Letter ID TRAUMATIC BRAIN-INJURY; HEAD-INJURY C1 [Xydakis, Michael S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Traumat Brain Injury Res Program, Bethesda, MD 20814 USA. [Xydakis, Michael S.; Ling, Geoffrey S. F.; Mulligan, Lisa P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ling, Geoffrey S. F.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Mulligan, Lisa P.] Uniformed Serv Univ Hlth Sci, Dept Neurosurg, Bethesda, MD 20814 USA. [Dorlac, Warren C.] Uniformed Serv Univ Hlth Sci, Dept Crit Care Surg, Bethesda, MD 20814 USA. [Dorlac, Warren C.] Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA. [Hack, Dallas C.] Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Xydakis, MS (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Traumat Brain Injury Res Program, Bethesda, MD 20814 USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0364-5134 EI 1531-8249 J9 ANN NEUROL JI Ann. Neurol. PD JUL PY 2013 VL 74 IS 1 BP 152 EP 154 DI 10.1002/ana.23895 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 282UH UT WOS:000329198600022 PM 23526742 ER PT J AU Sagripanti, JL Grote, G Niederwohrmeier, B Marschall, HJ AF Sagripanti, Jose-Luis Grote, Gudrun Niederwoehrmeier, Baerbel Marschall, Hans-Juergen TI Inactivation of Pseudomonas aeruginosa by Direct Sunlight SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article ID SOLAR ULTRAVIOLET-RADIATION; BACTERIA; SENSITIVITY; BIODEFENSE; RESISTANCE; RELEVANCE; ETIOLOGY AB We determined the sensitivity of Pseudomonas aeruginosa to direct sunlight radiation, while maintaining the experimental temperature below levels harmful to the bacterium. The results presented here were similar to previous data on solar sensitivity obtained half a world away on another related bacterial species. The findings presented in this study suggest that related bacteria have a characteristic sensitivity to sunlight with their survival depending mainly on the fluence (photons) received in a dose-dependent manner that is otherwise relatively independent from latitude, atmospheric ozone and other local conditions. Conditions that inactivated P. aeruginosa did not result in measurable impairment of specific polymerase chain reaction (PCR) or enzyme-linked immunoassays (ELISA) tests suggesting that this germ could still be amenable to detection after inactivation by sunlight. The results presented in this study should assist in predicting the survival of P. aeruginosa outdoors and in monitoring the risk posed by this widespread organism in a variety of environmental settings. C1 [Sagripanti, Jose-Luis] US Army, Edgewood Chem Biol Ctr, Adelphi, MD 20783 USA. [Grote, Gudrun; Niederwoehrmeier, Baerbel; Marschall, Hans-Juergen] ABC Schutz, WIS, Munster, Germany. RP Sagripanti, JL (reprint author), US Army, Edgewood Chem Biol Ctr, Adelphi, MD 20783 USA. EM joseluis.sagripanti@us.army.mil NR 25 TC 0 Z9 0 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-8655 EI 1751-1097 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD JUL PY 2013 VL 89 IS 4 SI SI BP 1000 EP 1003 DI 10.1111/php.12059 PG 4 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 284GN UT WOS:000329304200034 PM 23445191 ER PT J AU Lospinoso, DJ Fernelius, C Edhegard, KD Finger, DR Arora, NS AF Lospinoso, D. J. Fernelius, C. Edhegard, K. D. Finger, D. R. Arora, N. S. TI Lupus erythematosus/lichen planus overlap syndrome: successful treatment with acitretin SO LUPUS LA English DT Article DE Lupus erythematosus; lichen planus; lupus erythematosus; lichen planus overlap syndrome; acitretin; direct immunofluorescence staining ID LICHEN-PLANUS AB Lupus erythematosus/lichen planus overlap syndrome is a rare disorder combining the clinical, histological and immunopathological features of both lupus erythematosus (LE) and lichen planus (LP). Cutaneous lesions mostly affect the distal arms, legs, face and trunk. Palmoplantar involvement is felt to be characteristic of this condition. Plaques are often painful, centrally atrophic, bluish-red to hypopigmented in color, large, and scaly. On biopsy of clinically ambiguous lesions, histopathological features of one or both processes can be found, obscuring the diagnosis and complicating prognosis and treatment. Thus, direct immunofluorescence has become an essential tool in helping to diagnose this condition. In this report we describe the unique clinical and immunohistopathological manifestations of lupus erythematosus/lichen planus overlap syndrome along with a successful response to treatment with acitretin. C1 [Lospinoso, D. J.; Arora, N. S.] Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI 96859 USA. [Fernelius, C.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. [Edhegard, K. D.] Walter Reed Natl Mil Med Ctr, Dept Dermatol, Bethesda, MD USA. [Finger, D. R.] Tripler Army Med Ctr, Rheumatol Serv, Honolulu, HI 96859 USA. RP Arora, NS (reprint author), 4C Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI 96859 USA. EM navin.arora@us.army.mil NR 11 TC 4 Z9 4 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0961-2033 EI 1477-0962 J9 LUPUS JI Lupus PD JUL PY 2013 VL 22 IS 8 BP 851 EP 854 DI 10.1177/0961203313492243 PG 4 WC Rheumatology SC Rheumatology GA 257FP UT WOS:000327369300013 PM 23761099 ER PT J AU Goodwin, JA Coleman, EA Sullivan, E Easley, R McNatt, PK Chowdhury, N Stewart, CB AF Goodwin, Julia A. Coleman, Elizabeth Ann Sullivan, Ellen Easley, Robin McNatt, Paula K. Chowdhury, Nupur Stewart, Carol Beth TI Personal Financial Effects of Multiple Myeloma and Its Treatment SO CANCER NURSING LA English DT Article DE Disability; Employment; Financial; Insurance; Multiple myeloma; Out-of-pocket costs ID QUALITY-OF-LIFE; TERM SICK LEAVE; CANCER SURVIVORS; TREATMENT COSTS; FACT-BMT; WORK; RETURN; TRANSPLANT; CARE; CHEMOTHERAPY AB Background: Improvements in some treatment programs for multiple myeloma (MM) are increasing survival. As patients live longer with MM as a chronic disease, the personal financial effects of MM treatment become a serious concern. Objective: The objective of this study was to identify the personal financial effects of MM and its treatment in 5 areas: employment, disability, health/medical and life insurance, retirement, and out-of-pocket expenses. Methods: We mailed a questionnaire about financial issues to 1015 patients who had received intensive treatment for MM at the study site. Data analysis included descriptive statistics and comparisons using independent t tests. Results: Our sample (n = 762; mean age, 61 [SD, 9.26] years) experienced issues with employment (66% employed at diagnosis and treatment; 33% employed at questionnaire time), disability (35% applied), health/medical and life insurance (29% lost coverage and 8% changed coverage), retirement (13% retired during treatment), and out-of-pocket expenses (36% of income in first treatment year and 28% of income during most recent 12 months). Conclusions: Issues of employment, disability, health insurance, retirement, and out-of-pocket costs for treatment are major challenges for patients. Implications for Practice: In the midst of assessing physical needs during clinical trials for chemotherapy and stem cell transplants, healthcare providers must keep sight of patients' personal financial needs so that we can intervene promptly with referrals to social work, rehabilitation therapy, and other healthcare professions to help patients decrease the personal financial effects of MM and its treatment. C1 [Goodwin, Julia A.; Coleman, Elizabeth Ann; Sullivan, Ellen; McNatt, Paula K.] Univ Arkansas Med Sci, Coll Nursing, Little Rock, AR 72205 USA. [Stewart, Carol Beth] Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA. [Easley, Robin] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Chowdhury, Nupur] Univ Arkansas Med Sci, Coll Med, Dept Pediat, Little Rock, AR 72205 USA. [Sullivan, Ellen] Celgene Corp, Little Rock, AR USA. RP Goodwin, JA (reprint author), Univ Arkansas Med Sci, Coll Nursing, 4301 W Markham,Slot 529, Little Rock, AR 72205 USA. EM goodwinjuliaa@uams.edu FU National Institute of Nursing Research [P20 NR009006] FX Financial support was received from the National Institute of Nursing Research, P20 NR009006. NR 33 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0162-220X EI 1538-9804 J9 CANCER NURS JI Cancer Nurs. PD JUL-AUG PY 2013 VL 36 IS 4 BP 301 EP 308 DI 10.1097/NCC.0b013e3182693522 PG 8 WC Oncology; Nursing SC Oncology; Nursing GA 276IN UT WOS:000328743800015 PM 23047800 ER PT J AU Thomas, SJ AF Thomas, Stephen J. TI Dengue human infection model Re-establishing a tool for understanding dengue immunology and advancing vaccine development SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Editorial Material DE dengue; vaccine; experimental; human; infection; challenge ID PRIMARY-SCHOOL CHILDREN; HUMAN CHALLENGE; KAMPHAENG-PHET; HUMAN VOLUNTEERS; VIRUS-INFECTION; ANIMAL-MODELS; THAILAND; FEVER; SURVEILLANCE; MILITARY AB Dengue is an emerging and re-emerging disease of the tropics and sub-tropics. Millions of infections occur annually exacting a significant social, financial, and health care resource toll. Widespread use of a safe and efficacious dengue vaccine in cooperation with strategic vector control is the best hope for reducing the global dengue burden. Despite over 100 y of research exploring dengue immunology, pathogenesis, animal models, and vaccine and drug development there is no licensed vaccine or dengue anti-viral. No correlate of protection or validated animal model of disease has been defined. Experimental human infection with partially attenuated dengue viruses are documented as early as 1902 and have facilitated research efforts resulting in seminal discoveries and observations. It is time to explore re-invigorating the dengue human infection model to support dengue vaccine development. C1 Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. EM Stephen.thomas1@us.army.mil NR 54 TC 16 Z9 16 U1 2 U2 7 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JUL 1 PY 2013 VL 9 IS 7 BP 1587 EP 1590 DI 10.4161/hv.24188 PG 4 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 273YR UT WOS:000328572700038 PM 23466948 ER PT J AU Rao, M Peachman, KK Kim, J Gao, GF Alving, CR Michael, NL Rao, VB AF Rao, Mangala Peachman, Kristina K. Kim, Jiae Gao, Guofen Alving, Carl R. Michael, Nelson L. Rao, Venigalla B. TI HIV-1 Variable Loop 2 and its Importance in HIV-1 Infection and Vaccine Development SO CURRENT HIV RESEARCH LA English DT Article DE alpha 4 beta 7 integrin receptor; HIV-1; gp120; RV144; V2 loop; vaccine ID HUMAN-IMMUNODEFICIENCY-VIRUS; GP120 ENVELOPE GLYCOPROTEIN; NEUTRALIZING ANTIBODY-RESPONSE; HUMAN MONOCLONAL-ANTIBODY; EPITOPE FINE SPECIFICITY; ACUTE SIV INFECTION; T-CELL DEPLETION; SIMIAN IMMUNODEFICIENCY; EFFICACY TRIAL; V1/V2 REGION AB A vaccine that can prevent the transmission of HIV-1 at the site of exposure to the host is one of the best hopes to control the HIV-1 pandemic. The trimeric envelope spike consisting of heterodimers, gp120 and gp41, is essential for virus entry and thus has been a key target for HIV-1 vaccine development. However, it has been extremely difficult to identify the types of antibodies required to block the transmission of various HIV-1 strains and the immunogens that can elicit such antibodies due to the high genetic diversity of the HIV-1 envelope. The modest efficacy of the gp120 HIV-1 vaccine used in the RV144 Thai trial, including the studies on the immune correlates of protection, and the discovery of vaccine-induced immune responses to certain signature regions of the envelope have shown that the gp120 variable loop 2 (V2) is an important region. Since there is evidence that the V2 region interacts with the integrin 4 7 receptor of the host cell, and that this interaction might be important for virus capture, induction of antibodies against V2 loop could be postulated as one of the mechanisms to prevent the acquisition of HIV-1. Immunogens that can induce these antibodies should therefore be taken into consideration when designing HIV-1 vaccine formulations. C1 [Rao, Mangala; Peachman, Kristina K.; Kim, Jiae; Alving, Carl R.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Gao, Guofen; Rao, Venigalla B.] Catholic Univ Amer, Washington, DC 20064 USA. [Peachman, Kristina K.; Kim, Jiae] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, USMHRP, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave,Rm 2A08, Silver Spring, MD 20910 USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD) [W81XWH-11-2-0174]; VBR from the NIAID, NIH [AI102725] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD) and a grant to VBR from the NIAID, NIH (AI102725). NR 155 TC 10 Z9 10 U1 3 U2 6 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1570-162X EI 1873-4251 J9 CURR HIV RES JI Curr. HIV Res. PD JUL PY 2013 VL 11 IS 5 BP 427 EP 438 PG 12 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 262XR UT WOS:000327771700009 PM 24191938 ER PT J AU Blazes, DL Mullins, K Smoak, BL Jiang, J Canal, E Solorzano, N Hall, E Meza, R Maguina, C Myers, T Richards, AL Laughlin, L AF Blazes, David L. Mullins, Kristin Smoak, Bonnie L. Jiang, Ju Canal, Enrique Solorzano, Nelson Hall, Eric Meza, Rina Maguina, Ciro Myers, Todd Richards, Allen L. Laughlin, Larry TI Novel Bartonella Agent as Cause of Verruga Peruana SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CARRIONS-DISEASE; BACILLIFORMIS AB While studying chronic verruga peruana infections in Peru from 2003, we isolated a novel Bartonella agent, which we propose be named Candidatus Bartonella ancashi. This case reveals the inherent weakness of relying solely on clinical syndromes for diagnosis and underscores the need for a new diagnostic paradigm in developing settings. C1 [Blazes, David L.; Mullins, Kristin; Smoak, Bonnie L.; Laughlin, Larry] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Smoak, Bonnie L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jiang, Ju; Hall, Eric; Myers, Todd; Richards, Allen L.] Naval Med Res Ctr, Silver Spring, MD USA. [Canal, Enrique; Meza, Rina] Naval Med Res Unit 6, Lima, Peru. Hosp San Juan Dios, Lima, OH USA. [Maguina, Ciro] Univ Peruana Cayetano Heredia Trop, Lima, OH USA. RP Blazes, DL (reprint author), NMRC GEIS, 503 Robert Grant Ave,Bldg 500, Silver Spring, MD 20910 USA. EM da_blazes@hotmail.com FU Pfizer; Department of Defense Global Emerging Infection System [0000188M.0931.001. A0074] FX The original clinical trial was approved by the Institutional Review Boards of the Uniformed Services University of the Health Sciences, the Naval Medical Research Center, and the Universidad Peruana Cayetano Hefedia in 2002, and compared the standard of care medication, rifampin, with azithromycin. The clinical trial was originally funded by Pfizer and the subsequent pathogen characterization was funded by the Department of Defense Global Emerging Infection System work unit no. 0000188M.0931.001. A0074. The funding agencies had no role in writing, editing, or approval of this manuscript. NR 14 TC 9 Z9 11 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL PY 2013 VL 19 IS 7 BP 1111 EP 1114 DI 10.3201/eid1907.121718 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 268LZ UT WOS:000328173600013 PM 23764047 ER PT J AU Pratt, A Aboudara, M Lung, L AF Pratt, Alexandra Aboudara, Matthew Lung, Linn TI Polyuria Related to Dexmedetomidine SO ANESTHESIA AND ANALGESIA LA English DT Article ID CRITICALLY-ILL PATIENTS; MECHANICAL VENTILATION; ALCOHOL-WITHDRAWAL; SEDATION; PERMEABILITY; INHIBITION; MIDAZOLAM; PROPOFOL; SURGERY; TRIAL AB Dexmedetomidine has become a popular sedative in the intensive care unit for patients undergoing mechanical ventilation because of its highly selective -2 agonism, which exerts a combination of anesthetic, analgesic, and anxiolytic effects. Bradycardia and hypotension have been reported as the most common side effects of its use in large studies. Dexmedetomidine has been reported to induce polyuria by suppressing vasopressin secretion and increasing permeability of the collecting ducts in a dose-dependent fashion. We report a case of dexmedetomidine-related polyuria that occurred with a high-dose continuous infusion and subsequently resolved with discontinuation of the drug. (Anesth Analg 2013;117:150-2) C1 [Pratt, Alexandra] Washington Hosp Ctr, Dept Surg Crit Care, Washington, DC 20010 USA. [Aboudara, Matthew] Walter Reed Natl Mil Med Ctr, Dept Pulm & Crit Care, Bethesda, MD USA. [Lung, Linn] Georgetown Univ, Sch Med, Washington, DC USA. RP Aboudara, M (reprint author), Tripler Army Med Ctr, MCHK DM P, Pulm Clin, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM maboudara23@gmail.com NR 18 TC 2 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 EI 1526-7598 J9 ANESTH ANALG JI Anesth. Analg. PD JUL PY 2013 VL 117 IS 1 BP 150 EP 152 DI 10.1213/ANE.0b013e3182917c86 PG 3 WC Anesthesiology SC Anesthesiology GA 246BV UT WOS:000326512300024 PM 23632050 ER PT J AU Abbas, MI Oliva-Hemker, M Choi, J Lustik, M Gilger, MA Noel, RA Schwarz, K Nylund, CM AF Abbas, Mazen I. Oliva-Hemker, Maria Choi, Joon Lustik, Michael Gilger, Mark A. Noel, R. Adam Schwarz, Kathleen Nylund, Cade M. TI Magnet Ingestions in Children Presenting to US Emergency Departments, 2002-2011 SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Article DE Consumer Product Safety Commission; foreign body; ingestion; magnet; National Electronic Injury Surveillance System ID UNITED-STATES; COMPLICATIONS; ATTRACTION; MANAGEMENT; INJURIES AB Background and Objective:In the last 10 years, there have been an increasing number of case reports concerning gastrointestinal injury related to magnet ingestions; however, the magnitude of the problem remains to be clearly defined. The aim of the study was to examine the epidemiology of magnet ingestion-related emergency department (ED) visits among children in the United States.Methods:We performed a trend analysis using a nationally representative sample from the US Consumer Product Safety Commission, National Electronic Injury Surveillance System (NEISS) database for ED visits involving magnet ingestion in children younger than 18 years from 2002 to 2011.Results:A national estimate of 16,386 (95% CI 12,175-20,598) children younger than 18 years presented to EDs in the United States during the 10-year study period with possible magnet ingestion. The incidence of visits increased 8.5-fold (from 0.45/100,000 to 3.75/100,000) from 2002 to 2011 with a 75% average annual increase per year. The majority of patients reported to have ingested magnets were younger than 5 years (54.7%). From 2009 to 2011 there was an increase in older children ingesting multiple small and/or round magnets, with a mean average age of 7.10.56 years during the study period.Conclusions:There has been an alarming increase in ED visits for magnet ingestion in children. Increased public education and prevention efforts are needed. C1 [Abbas, Mazen I.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Oliva-Hemker, Maria; Schwarz, Kathleen] Johns Hopkins Univ, Sch Med, Div Pediat Gastroenterol & Nutr, Baltimore, MD USA. [Choi, Joon] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA. [Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Gilger, Mark A.] Baylor Coll Med, Houston, TX 77030 USA. [Noel, R. Adam] Louisiana State Univ, Hlth Sci Ctr, Sect Pediat Gastroenterol, Dept Pediat, New Orleans, LA USA. [Nylund, Cade M.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Abbas, MI (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM mazen.abbas@us.army.mil OI Nylund, Cade/0000-0003-4543-6804 FU NCATS NIH HHS [UL1 TR000077] NR 19 TC 12 Z9 13 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-2116 EI 1536-4801 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD JUL PY 2013 VL 57 IS 1 BP 18 EP 22 DI 10.1097/MPG.0b013e3182952ee5 PG 5 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA 248ZD UT WOS:000326744500013 PM 23575300 ER PT J AU Smith, T Nakamura-Messenger, K Messenger, S Keller, LP Khodja, H Raepsaet, C Wirick, S Flynn, GJ Taylor, S Engrand, C Duprat, J Herzog, GF AF Smith, T. Nakamura-Messenger, K. Messenger, S. Keller, L. P. Khodja, H. Raepsaet, C. Wirick, S. Flynn, G. J. Taylor, S. Engrand, C. Duprat, J. Herzog, G. F. TI C/N AND OTHER ELEMENTAL RATIOS OF CHONDRITIC POROUS IDPS AND A FLUFFY CONCORDIA MICROMETEORITE SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 76th Annual Meeting of the Meteoritical-Society CY JUL 29-AUG 02, 2013 CL Edmonton, CANADA SP Meteorit Soc ID SNOW C1 [Smith, T.; Khodja, H.; Raepsaet, C.] CEA Saclay, Gif Sur Yvette, France. [Smith, T.] U Bern, Bern, Switzerland. [Nakamura-Messenger, K.; Messenger, S.; Keller, L. P.] NASA JSC, Houston, TX 77058 USA. [Wirick, S.] U Chicago, CARS, Chicago, IL 60637 USA. [Flynn, G. J.] SUNY Coll Plattsburgh, Plattsburgh, NY 12901 USA. [Taylor, S.] CRREL, Hanover, NH 03755 USA. [Engrand, C.; Duprat, J.] U Paris Sud, CSNSM CNRS, Orsay, France. [Herzog, G. F.] Rutgers U, Piscataway, NJ 08854 USA. RI Khodja, Hicham/A-1869-2016 NR 8 TC 0 Z9 0 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1086-9379 EI 1945-5100 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2013 VL 48 SU 1 SI SI BP A322 EP A322 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 237JN UT WOS:000325865800292 ER PT J AU Fischer, C Hulten, E Belur, P Smith, R Voros, S Villines, TC AF Fischer, Collin Hulten, Edward Belur, Pallavi Smith, Ryan Voros, Szilard Villines, Todd C. TI Coronary CT angiography versus intravascular ultrasound for estimation of coronary stenosis and atherosclerotic plaque burden: A meta-analysis SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY LA English DT Article DE Coronary computed tomography angiography; Intravascular ultrasound; Plaque detection; Plaque quantification; Meta-analysis ID MULTIDETECTOR COMPUTED-TOMOGRAPHY; FRACTIONAL FLOW RESERVE; INTRACORONARY ULTRASOUND; NONINVASIVE DETECTION; SYSTEMATIC REVIEWS; VIRTUAL HISTOLOGY; STATIN THERAPY; ARTERY PLAQUES; ASTEROID TRIAL; QUANTIFICATION AB Background: Numerous studies have compared coronary CT angiography (CTA) with quantitativecoronary angiography. However, the ability of coronary CTA to identify atherosclerosis and to accurately measure plaque and coronary area and volume measurements as compared with intravascular ultrasound (IVUS) has not been fully defined. Objective: We sought to assess the ability of coronary CTA to quantify coronary and plaque measurements commonly performed with IVUS. Methods: We searched multiple databases for diagnostic studies that directly compared coronary CTA and IVUS for coronary plaque detection, vessel luminal area, percentage of area stenosis, plaque area, and plaque volume. We used a bivariate mixed-effects binomial regression model to pool test sensitivity and specificity for detection of any coronary plaque. Results: Forty-two studies that evaluated 1360 patients (75% men; mean age, 59 years) were identified. No significant difference was found between coronary CTA and IVUS measurements of vessel lumen cross-sectional area, plaque area, percentage of area stenosis, or plaque volume within the overall cohort and no difference for the measurement of cross-sectional area (n = 5 studies) and plaque volume (n = 8 studies) among a subgroup that used automated or semiautomated measurement techniques. Sensitivity and specificity of coronary CTA to detect any plaque compared with NUS were 93% and 92%, respectively, with an area under the receiver-operating curve of 0.97. Conclusions: Compared with IVUS, coronary CTA appears to be highly accurate for estimation of luminal area, percentage of area stenosis, plaque volume, and plaque area and for detection of plaque. The use of automated vessel and stenosis measurements appears promising in limited studies to date. Published by Elsevier, Inc on behalf of Society of Cardiovascular Computed Tomography. C1 [Fischer, Collin] Dwight D Eisenhower Army Med Ctr, Serv Cardiol, Ft Gordon, GA 30905 USA. [Hulten, Edward] Brigham & Womens Hosp, Dept Cardiol & Radiol, Boston, MA 02115 USA. [Hulten, Edward] Harvard Univ, Sch Med, Boston, MA USA. [Belur, Pallavi] Walter Reed Natl Mil Med Ctr, Internal Med Serv, Bethesda, MD USA. [Smith, Ryan; Villines, Todd C.] Walter Reed Natl Mil Med Ctr, Serv Cardiol, Bethesda, MD USA. [Voros, Szilard] SUNY Stony Brook, Dept Radiol, Med Ctr, Stony Brook, NY 11794 USA. RP Fischer, C (reprint author), Dwight D Eisenhower Army Med Ctr, Serv Cardiol, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM collinfischer@msn.com OI Hulten, Edward/0000-0001-9281-0032; Villines, Todd/0000-0003-2674-3702 FU Merck Inc; HDL Inc; Global Genomics Group LLC FX Dr. Voros has received grant support from Merck Inc; is an advisor for Toshiba and Vital Images; has received a salary from HDL Inc and Global Genomics Group LLC; and is owner or holds equity and stock in G3 Founders LLC, Innovations in Integrated Imaging LLC, Integrated Cardiovascular Research Group, LLC. Innovations in Integrated Imaging has pending patent application on Lesion-Specific Coronary Artery calcium scoring. The other authors report no conflict of interest. NR 60 TC 29 Z9 30 U1 0 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-5925 J9 J CARDIOVASC COMPUT JI J. Cardiovasc. Comput. Tomogr. PD JUL-AUG PY 2013 VL 7 IS 4 BP 256 EP 266 DI 10.1016/j.jcct.2013.08.006 PG 11 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA 244BF UT WOS:000326361400007 PM 24148779 ER PT J AU Le, Q Kaplan, LM AF Le, Qiang Kaplan, Lance M. TI Probability Hypothesis Density-Based Multitarget Tracking for Proximity Sensor Networks SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID MULTIPLE-TARGET TRACKING; PHD FILTER AB An investigation of the feasibility of a mesh network of proximity sensors to track targets is presented. In such a network the sensors report binary detection/nondetection measurements for the targets within proximity. A new probability hypothesis density (PHD) filter and its particle implementation for multiple-target tracking in a proximity sensor network are proposed. The performance and robustness of the new method are evaluated over simulated matching and mismatching cases for the sensor models. The simulations demonstrate the utility of the PHD filter to both track the number of targets and their locations. C1 [Le, Qiang] Hampton Univ, Dept Engn, Sch Engn & Technol, Hampton, VA 23668 USA. [Kaplan, Lance M.] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. RP Le, Q (reprint author), Hampton Univ, Dept Engn, Sch Engn & Technol, OLIN 318 M, Hampton, VA 23668 USA. EM qiang.le@hamptonu.edu FU Army Research Laboratory [W911NF-09-2-0041] FX The research was sponsored by the Army Research Laboratory under Cooperative Agreement W911NF-09-2-0041. NR 32 TC 4 Z9 5 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2013 VL 49 IS 3 BP 1476 EP 1496 PG 21 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 235ZG UT WOS:000325761900007 ER PT J AU Yang, C Kaplan, L Blasch, E Bakich, M AF Yang, Chun Kaplan, Lance Blasch, Erik Bakich, Michael TI Optimal Placement of Heterogeneous Sensors for Targets with Gaussian Priors SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID LOCALIZATION; MANAGEMENT; TRACKING; ARRAY; GDOP AB An optimal strategy for geometric sensor placement to enhance target tracking performance is developed. Recently, a considerable amount of work has been published on optimal conditions for single-update placement of homogeneous sensors (same type and same measurement quality) in which the targets are either assumed perfectly known or the target location uncertainty is averaged out via the expected value of the determinant of the Fisher information matrix (FIM). We derive conditions for optimal placement of heterogeneous sensors based on maximization of the information matrix to be updated by the heterogeneous sensors from an arbitrary Gaussian prior characterizing the uncertainty about the initial target location. The heterogeneous sensors can be of the same or different types (ranging sensors, bearing-only sensors, or both). The sensors can also make, over several time steps, multiple independent measurements of different qualities. Placement strategies are derived and their performance is illustrated via simulation examples. C1 [Yang, Chun] Sigtem Technol Inc, San Mateo, CA 94402 USA. [Kaplan, Lance] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD USA. [Blasch, Erik; Bakich, Michael] AFRL, Rome, NY USA. [Blasch, Erik] AFRL, Wright Patterson AFB, OH USA. RP Yang, C (reprint author), Sigtem Technol Inc, 1343 Parrott Dr, San Mateo, CA 94402 USA. EM chunyang@sigtem.com FU [FA8650-08-C-1407] FX This research is supported in part under Contract FA8650-08-C-1407. NR 34 TC 22 Z9 22 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2013 VL 49 IS 3 BP 1637 EP 1653 PG 17 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 235ZG UT WOS:000325761900016 ER PT J AU Guo, S Bajdich, M Mitas, L Reynolds, PJ AF Guo, Shi Bajdich, Michal Mitas, Lubos Reynolds, Peter J. TI Study of dipole moments of LiSr and KRb molecules by quantum Monte Carlo methods SO MOLECULAR PHYSICS LA English DT Article DE ultracold polar molecules; LiSr; KRb; quantum Monte Carlo; fixed-node approximation; electron correlation; quantum simulations ID POLAR-MOLECULES; LATTICE CLOCK; GAS AB Heteronuclear dimers are of significant interest to experiments seeking to exploit ultracold polar molecules in a number of novel ways, including precision measurement, quantum computing and quantum simulation. We calculate highly accurate Born-Oppenheimer total energies and electric dipole moments as a function of internuclear separation for two such dimers, LiSr and KRb. We apply fully correlated, high-accuracy quantum Monte Carlo methods for evaluating these molecular properties in a many-body framework. We use small-core effective potentials combined with multi-reference Slater-Jastrow trial wave functions to provide accurate nodes for the fixed-node diffusion Monte Carlo method. For reference and comparison, we calculate the same properties with Hartree-Fock and with restricted Configuration Interaction methods, and carefully assess the impact of the recovered many-body correlations on the calculated quantities. For LiSr, we find a highly non-linear dipole moment curve, which may make this molecule's dipole moment tunable through vibrational state control. C1 [Guo, Shi; Mitas, Lubos; Reynolds, Peter J.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Bajdich, Michal] Univ Calif Berkeley, Lawrence Berkeley Lab, Joint Ctr Artificial Photosynth, Berkeley, CA 94720 USA. [Bajdich, Michal] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA. [Reynolds, Peter J.] Army Res Off, Div Phys, Res Triangle Pk, NC 27703 USA. [Reynolds, Peter J.] Army Res Off, Phys Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Reynolds, PJ (reprint author), N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. EM peter.j.reynolds16.civ@mail.mil FU US Army Research Office FX We gratefully acknowledge support by the US Army Research Office. NR 82 TC 2 Z9 2 U1 1 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0026-8976 EI 1362-3028 J9 MOL PHYS JI Mol. Phys. PD JUL 1 PY 2013 VL 111 IS 12-13 SI SI BP 1744 EP 1752 DI 10.1080/00268976.2013.788741 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 240CE UT WOS:000326071500012 ER PT J AU Trainor, KJ Foust, BW Landis, EN AF Trainor, Kevin J. Foust, Bradley W. Landis, Eric N. TI Measurement of Energy Dissipation Mechanisms in Fracture of Fiber-Reinforced Ultrahigh-Strength Cement-Based Composites SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article DE Cracking; Damage; Cement; Fiber reinforced materials; Composite materials; Energy dissipation; Measurement; Fracture; Damage; Fiber reinforced cement-based composites; X-ray tomography AB In the study described here, reinforced and unreinforced specimens of reactive powder concrete were scanned using an X-ray computed tomography (CT) imaging system that allowed characterization and measurement of internal features. The X-ray CT imaging was done in conjunction with three-point bending tests of notched beam specimens. Unreinforced specimens were used to measure specific fracture energy in a way that accounts for the irregular shape of the fracture surface. For fiber-reinforced specimens, 3D digital image analysis techniques were used to measure fiber volume fraction, as well as the orientation of each individual fiber. In postfracture scans, the total amount of internal cracking was measured, as was the degree of fiber pullout relative to undamaged specimens. Measurements show that with a nominal steel fiber volume fraction between 3.5 and 4.0% there can be a greater than a 100-fold increase in the net work of load. Through quantitative analysis of the tomographic images, we could account for close to 90% of that increase. The analysis shows that roughly half of the internal energy dissipation comes from matrix cracking, including the crack branching and multiple crack systems facilitated by the fibers, while the remaining energy dissipation is a result of fiber pullout. C1 [Trainor, Kevin J.; Landis, Eric N.] Univ Maine, Dept Civil & Environm Engn, Orono, ME 04469 USA. [Foust, Bradley W.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GS M, Vicksburg, MS 39180 USA. RP Landis, EN (reprint author), Univ Maine, Dept Civil & Environm Engn, 5711 Boardman Hall, Orono, ME 04469 USA. EM landis@maine.edu FU Engineer Research and Development Center (ERDC) of the U.S. Army Corps of Engineers [W912HZ-09-C-0059] FX This work was conducted under Contract W912HZ-09-C-0059 from the Engineer Research and Development Center (ERDC) of the U.S. Army Corps of Engineers. The authors gratefully acknowledge the assistance of Prof. Rey Roque and George Lopp at the University of Florida Advanced Materials Laboratory, where much of this work was conducted. The contributions of Undergraduate Research Assistants Lauren Flanders, Katrina Martin, and Elizabeth Reynolds are also acknowledged. Permission to publish this information was granted by the Director, Geotechnical and Structures Laboratory. NR 11 TC 5 Z9 5 U1 1 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD JUL 1 PY 2013 VL 139 IS 7 BP 771 EP 779 DI 10.1061/(ASCE)EM.1943-7889.0000545 PG 9 WC Engineering, Mechanical SC Engineering GA 229PE UT WOS:000325278600001 ER PT J AU Benson, M Yapa, SD Elkins, C Eaton, JK AF Benson, Michael Yapa, Sayuri D. Elkins, Chris Eaton, John K. TI Experimental-Based Redesigns for Trailing Edge Film Cooling of Gas Turbine Blades SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article ID PERFORMANCE; AIRFOILS; CUTBACK AB Magnetic resonance imaging experiments have provided the three-dimensional mean concentration and three component mean velocity field for a typical trailing edge film-cooling cutback geometry built into a conventional uncambered airfoil. This geometry is typical of modern aircraft engines and includes three dimensional slot jets separated by tapered lands. Previous analysis of these data identified the critical mean flow structures that contribute to rapid mixing and low effectiveness in the fully turbulent flow. Three new trailing edge geometries were designed to modify the large scale mean flow structures responsible for surface effectiveness degradation. One modification called the Dolphin Nose attempted to weaken strong vortex flows by reducing three dimensionality near the slot breakout. This design changed the flow structure but resulted in minimal improvement in the surface effectiveness. Two other designs called the Shield and Rounded Shield changed the land planform and added an overhanging land edge while maintaining the same breakout surface. These designs substantially modified the vortex structure and improved the surface effectiveness by as much as 30%. Improvements included superior coolant uniformity on the breakout surface which reduces potential thermal stresses. The utilization of the time averaged data from combined magnetic resonance velocimetry (MRV) and concentration (MRC) experiments for designing improved trailing edge breakout film cooling is demonstrated. C1 [Benson, Michael] US Mil Acad, West Point, NY 10966 USA. [Yapa, Sayuri D.; Elkins, Chris; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA. RP Benson, M (reprint author), US Mil Acad, West Point, NY 10966 USA. EM michael.benson@us.army.mil; yapasd@stanford.edu; celkins@stanford.edu; eatonj@stanford.edu FU General Electric under the University Strategic Alliance program; U. S. Army Research Office [57392-EG-II]; United States Army FX Financial support for the project was provided by General Electric under the University Strategic Alliance program. In addition, this material is based upon work supported in part by the U. S. Army Research Office under Contract/Grant Nos. 57392-EG-II. Use of the facilities at the Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging is gratefully acknowledged. The authors wish to thank the United States Army for funding the first author in his doctoral studies at Stanford, and the reviewers whose suggestions have improved the quality of the paper. The views expressed herein are those of the authors and do not purport to reflect the position of the Department of the Army, or the Department of Defense. NR 25 TC 0 Z9 0 U1 0 U2 17 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X EI 1528-8900 J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD JUL PY 2013 VL 135 IS 4 AR 041018 DI 10.1115/1.4007601 PG 9 WC Engineering, Mechanical SC Engineering GA 239KI UT WOS:000326021900018 ER PT J AU Briggs, MJ Silver, A Kopp, PJ Santangelo, FA Mathis, IA AF Briggs, Michael J. Silver, Andrew Kopp, Paul J. Santangelo, Frank A. Mathis, Ian A. TI Validation of a Risk-Based Numerical Model for Predicting Deep-Draft Underkeel Clearance SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Navigation; Channels; Probabilities; Design; Ships; Numerical models; Risk management; Navigation; Channels; Underkeel clearance; Probabilistic deep-draft channel design; Wave-induced ship motions; DGPS ship measurements AB The channel analysis and design evaluation tool (CADET) is a numerical program to determine the optimum dredge depth for the offshore portions of entrance channels. A brief description of the theoretical basis and risk assessment in CADET is presented. Validation comparisons between CADET predictions and field measurements of wave-induced vertical motions at Ambrose Channel, New York, are presented. Prototype ship motions were measured with a differential global positioning system in April 1998 along three 488-m-long reaches. Comparisons were made with six ships, three tankers and three containerships, during inbound and outbound transits. In general, the CADET predictions matched the field measurements reasonably well, especially considering the wave heights were relatively small during the measurement period. (C) 2013 American Society of Civil Engineers. C1 [Briggs, Michael J.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Silver, Andrew; Kopp, Paul J.] Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD 20817 USA. [Santangelo, Frank A.] US Army, Corps Engineers, New York, NY 10278 USA. [Mathis, Ian A.] US Army, Inst Water Resources, Corps Engineers, Alexandria, VA 22315 USA. RP Briggs, MJ (reprint author), US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Michael.J.Briggs@usace.army.mil; Andrew.Silver@navy.mil; Paul.Kopp@navy.mil; Frank.A.Santangelo@usace.army.mil; Ian.A.Mathis@usace.army.mil FU Coastal and Hydraulics Laboratory (CHL) Improved Ship Simulations Work Unit in the Navigation Systems Research Program; IWR Optimization Tools for Navigation (OTN) Program FX The authors wish to acknowledge Headquarters, U.S. Army Corps of Engineers, the Institute for Water Resources (IWR), and the Naval Surface Warfare Center, Carderock Division, for authorizing publication of this paper. This study was supported by the Coastal and Hydraulics Laboratory (CHL) Improved Ship Simulations Work Unit in the Navigation Systems Research Program and the IWR Optimization Tools for Navigation (OTN) Program. The authors would like to acknowledge the assistance of the New York District, and Randy McCollum and Terry Waller, CHL, for providing channel, ship, and DGPS data. The authors also wish to thank the reviewers for their useful suggestions. NR 16 TC 3 Z9 3 U1 0 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT C JI J. Waterw. Port Coast. Ocean Eng. PD JUL 1 PY 2013 VL 139 IS 4 BP 267 EP 276 DI 10.1061/(ASCE)WW.1943-5460.0000176 PG 10 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 239KF UT WOS:000326021500003 ER PT J AU Kerr, PC Westerink, JJ Dietrich, JC Martyr, RC Tanaka, S Resio, DT Smith, JM Westerink, HJ Westerink, LG Wamsley, T van Ledden, M de Jong, W AF Kerr, P. C. Westerink, J. J. Dietrich, J. C. Martyr, R. C. Tanaka, S. Resio, D. T. Smith, J. M. Westerink, H. J. Westerink, L. G. Wamsley, T. van Ledden, M. de Jong, W. TI Surge Generation Mechanisms in the Lower Mississippi River and Discharge Dependency SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Levees and dikes; Storm surges; Floods; Louisiana; Mississippi River; Hurricanes; Water discharge; Levee design; Storm surge; River stage; Flooding; Southeastern Louisiana; Mississippi River; ADCIRC; Surge propagation; Surge attenuation; Hurricane Katrina ID HURRICANE STORM-SURGE; SOUTHERN LOUISIANA; KATRINA; SYSTEM; WAVES; MODEL AB The Lower Mississippi River protrudes into the Gulf of Mexico, and manmade levees line only the west bank for 55 km of the Lower Plaquemines section. Historically, sustained easterly winds from hurricanes have directed surge across Breton Sound, into the Mississippi River and against its west bank levee, allowing for surge to build and then propagate efficiently upriver and thus increase water levels past New Orleans. This case study applies a new and extensively validated basin- to channel-scale, high-resolution, unstructured-mesh ADvanced CIRCulation model to simulate a suite of historical and hypothetical storms under low to high river discharges. The results show that during hurricanes, (1) total water levels in the lower river south of Pointe a La Hache are only weakly dependent on river flow, and easterly wind-driven storm surge is generated on top of existing ambient strongly flow-dependent river stages, so the surge that propagates upriver reduces with increasing river flow; (2) natural levees and adjacent wetlands on the east and west banks in the Lower Plaquemines capture storm surge in the river, although not as effectively as the manmade levees on the west bank; and (3) the lowering of manmade levees along this Lower Plaquemines river section to their natural state, to allow storm surge to partially pass across the Mississippi River, will decrease storm surge upriver by 1 to 2 m between Pointe a La Hache and New Orleans, independent of river flow. (C) 2013 American Society of Civil Engineers. C1 [Kerr, P. C.; Westerink, J. J.; Martyr, R. C.; Westerink, H. J.; Westerink, L. G.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Dietrich, J. C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Tanaka, S.] Univ Tokyo, Earthquake Res Inst, Tokyo 113, Japan. [Resio, D. T.] Univ N Florida, Dept Civil Engn, Jacksonville, FL 32224 USA. [Smith, J. M.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wamsley, T.] US Army, Flood & Storm Protect Div, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [van Ledden, M.] Haskoning Nederland BV, Business Dev, Business Line Water, NL-3009 AM Rotterdam, Netherlands. [de Jong, W.] Haskoning Nederland BV, Advisory Grp Hydraul & Morphol, NL-6500 AD Nijmegen, Netherlands. RP Kerr, PC (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. EM pkerr@nd.edu RI Dietrich, Joel/E-5161-2011 OI Dietrich, Joel/0000-0001-5294-2874 NR 29 TC 5 Z9 5 U1 1 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT C JI J. Waterw. Port Coast. Ocean Eng. PD JUL 1 PY 2013 VL 139 IS 4 BP 326 EP 335 DI 10.1061/(ASCE)WW.1943-5460.0000185 PG 10 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 239KF UT WOS:000326021500009 ER PT J AU Kobayashi, N Pietropaolo, J Melby, JA AF Kobayashi, Nobuhisa Pietropaolo, Jill Melby, Jeffrey A. TI Deformation of Reef Breakwaters and Wave Transmission SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Reefs; Breakwaters; Damage; Wave overtopping; Numerical models; Wave actions; Coefficients; Wave crest; Reef breakwaters; Rubble mounds; Damage; Wave overtopping; Wave transmission AB The risk-based design of a reef breakwater requires the prediction of the temporal variations of the damage and wave transmission coefficient during storms. The cross-shore numerical model is extended to the landward zone of the wave transmission. The extended model is compared with 148 tests for a reef breakwater with a narrow crest at or above the still water level where the narrow crest was lowered by wave action. The model is also compared with an experiment on a wide-crested submerged breakwater in which the crest height increased during 20-h wave action. The damage, crest height, and wave transmission coefficient are predicted reasonably well; however, the damaged profile is not predicted accurately. (C) 2013 American Society of Civil Engineers. C1 [Kobayashi, Nobuhisa] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Pietropaolo, Jill] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Melby, Jeffrey A.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. EM nk@udel.edu FU U.S. Army Corps of Engineers Coastal and Hydraulics Laboratory [W912HZ-11-P-0173]; EU THESEUS Project FX This study was partially supported by the U.S. Army Corps of Engineers Coastal and Hydraulics Laboratory under Contract No. W912HZ-11-P-0173 and by the EU THESEUS Project. NR 9 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT C JI J. Waterw. Port Coast. Ocean Eng. PD JUL 1 PY 2013 VL 139 IS 4 BP 336 EP 340 DI 10.1061/(ASCE)WW.1943-5460.0000180 PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 239KF UT WOS:000326021500010 ER PT J AU Paez, A Paez, PM Gonzalez, ME Urdaneta, JA Ringelberg, D Tschaplinski, TJ AF Paez, A. Paez, P. M. Gonzalez, M. E. Urdaneta, J. A. Ringelberg, D. Tschaplinski, T. J. TI The effect of light on fatty acid concentrations of purslane (Portulaca oleracea L.): A promising plant for decreasing serum cholesterol levels SO REVISTA DE LA FACULTAD DE AGRONOMIA DE LA UNIVERSIDAD DEL ZULIA LA English DT Article DE Purslane; Portulaca oleracea; colesterol; fatty acids; irradiance ID COMMON PURSLANE; OMEGA-3-FATTY-ACIDS; ANTIOXIDANTS; DIET AB Purslane (Portulaca oleracea L.), a widely-distributed annual herb, was grown under three irradiances to determine the effect of light on fatty acid concentration of leaves, and to establish its potential effect on lowering serum cholesterol levels in rabbits which were previously submitted under a coconut oil rich diet. The seedlings grown under full sun, partial (30% of full sun) and deep shade (10% of full sun) were analyzed by gas chromatography for fatty acid concentrations, and fed to rabbits with induced high serum cholesterol. The lower irradiances tended to increase concentrations of polar fraction fatty acids in leaves, including 18:3w3, an omega 3 fatty acid and 18:2w6. The relative proportion of fatty acids changed under low irradiance which also reduced the mole fraction of a number of saturated fatty acids, including 14:0, 23:0, 24:0 and 25:0. The experiments with rabbits, fed with a coconut oil rich diet to induce high blood cholesterol, indicated that Purslane rapidly decreased the high cholesterol concentration. Low light-grown Purslane was a good source of polyunsaturated fatty acids, and had the potential to lower serum cholesterol. C1 [Paez, A.; Gonzalez, M. E.; Urdaneta, J. A.] Univ Zulia, Fac Ciencias Expt, Dept Biol, Lab Ecofisiol, Maracaibo 4011, Venezuela. [Paez, P. M.] Univ Zulia, Fac Med, Maracaibo 4011, Venezuela. [Ringelberg, D.] US Army, CRREL, Hanover, NH 03755 USA. [Tschaplinski, T. J.] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. RP Paez, A (reprint author), Univ Zulia, Fac Ciencias Expt, Dept Biol, Lab Ecofisiol, Maracaibo 4011, Venezuela. EM apaezsalasar@gmail.com FU CONDES (Universidad del Zulia) in Venezuela; FONACIT in Venezuela; program of the Bioenergy Feedstock Development, US Department of Energy in the Oak Ridge National Laboratory; US Department of Energy [DE-AC05-00OR22725] FX The authors thank CONDES (Universidad del Zulia) and FONACIT by financing the part of the research carried out in Venezuela. Likewise, the authors express their gratitude by the finance and support provided by the program of the Bioenergy Feedstock Development, US Department of Energy in the Oak Ridge National Laboratory, managed by UT-Battelle, LLC of the US Department of Energy, under the contract No DE-AC05-00OR22725, and the Laboratory of IPPLUZ, Universidad del Zulia, where were carried out the determinations of the plasmatic cholesterol. NR 15 TC 0 Z9 0 U1 2 U2 15 PU UNIV ZULIA, FACULTAD AGRONOMIA PI MARACAIBO PA APARTADO 15205, MARACAIBO, ZU 4005, VENEZUELA SN 0378-7818 J9 REV FAC AGRON LUZ JI Rev. Fac. Agron. PD JUL-SEP PY 2013 VL 30 IS 3 BP 441 EP 453 PG 13 WC Agronomy SC Agriculture GA 240YA UT WOS:000326132400006 ER PT J AU Westrick, RB Fogarty, BT Johnson, MR AF Westrick, Richard B. Fogarty, Brian T. Johnson, Michael R. TI Posterior Labral Tear With a Paralabral Cyst Causing Suprascapular Nerve Compression SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Westrick, Richard B.; Johnson, Michael R.] US Mil Baylor Univ Doctoral Residency Sports Phys, West Point, NY USA. [Fogarty, Brian T.] Keller Army Community Hosp, West Point, NY USA. RP Westrick, RB (reprint author), US Mil Baylor Univ Doctoral Residency Sports Phys, West Point, NY USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2013 VL 43 IS 7 BP 511 EP 511 DI 10.2519/jospt.2013.0412 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 236FW UT WOS:000325781900010 PM 23812236 ER PT J AU Tiede, J Brown, L Gekht, G Vallejo, R Yearwood, T Morgan, D AF Tiede, Jeffrey Brown, Lora Gekht, Gennady Vallejo, Ricardo Yearwood, Thomas Morgan, Donna TI Novel Spinal Cord Stimulation Parameters in Patients with Predominant Back Pain SO NEUROMODULATION LA English DT Article DE Axial back pain; failed back surgery syndrome; high frequency; low back pain; neuromodulation; neurostimulation; spinal cord stimulation ID SURGERY SYNDROME; CONTROLLED-TRIAL; NEUROPATHIC PAIN; COMPLICATIONS; SYSTEM; LEAD AB Objectives To examine the feasibility of novel high-frequency spinal cord stimulation therapy in a cohort of patients with chronic predominant back pain during a four day, percutaneous trial. Design Prospective, multicenter open label pilot trial. Setting and Patients:Twenty-four patients with back pain greater than leg pain who were candidates for spinal cord stimulation were trialed at five U.S. centers. Interventions Patients completed a percutaneous trial with a commercially available spinal cord stimulator. The implanted leads were then connected to the novel external stimulation device and patients were trialed for an additional four days. Outcome Measures Pain intensity ratings, subjective descriptions, and patients' preference. Results There was significant improvement from baseline in overall pain scores (8.68 to 2.03, [p < 0.001]) and back pain scores (8.12 to 1.88, [p < 0.001]) with the investigational stimulation. The investigational stimulation was preferred to the commercially available systems in 21 of 24 patients (88%). Conclusions Patients with predominant back pain reported a substantial reduction in overall pain and back pain when trialed with high-frequency spinal cord stimulation therapy. C1 [Tiede, Jeffrey] DDEAMC, Ft Gordon, GA 30905 USA. [Brown, Lora; Gekht, Gennady] Coastal Orthoped, Bradenton, FL USA. [Vallejo, Ricardo] Millennium Pain Ctr, Bloomington, IL USA. [Yearwood, Thomas] Comprehens Pain Rehabil, Pascagoula, MS USA. [Morgan, Donna] Pain Res Oregon LLC, Eugene, OR USA. RP Tiede, J (reprint author), DDEAMC, Dept Pain Management, 300 Hosp Rd Ft, Ft Gordon, GA 30905 USA. EM jeffrey.m.tiede@us.army.mil FU Nevro Corp., Menlo Park, CA FX The study was sponsored by a grant from Nevro Corp., Menlo Park, CA. The investigators of the study also include Joseph Meyer, Richard Wolkowitz, Ramsin Benyamin, Joseph Dunn, Peter Kosek, and Brian Starr. NR 20 TC 35 Z9 35 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1094-7159 EI 1525-1403 J9 NEUROMODULATION JI Neuromodulation PD JUL-AUG PY 2013 VL 16 IS 4 BP 370 EP 375 DI 10.1111/ner.12032 PG 6 WC Medicine, Research & Experimental; Clinical Neurology SC Research & Experimental Medicine; Neurosciences & Neurology GA 238EN UT WOS:000325925100014 PM 23433237 ER PT J AU Yoganandan, N Stemper, BD Pintar, FA Maiman, DJ McEntire, BJ Chancey, VC AF Yoganandan, Narayan Stemper, Brian D. Pintar, Frank A. Maiman, Dennis J. McEntire, B. Joseph Chancey, Valeta Carol TI Cervical spine injury biomechanics: Applications for under body blast loadings in military environments SO CLINICAL BIOMECHANICS LA English DT Review DE Human cervical spine; Injury risk curves; Experimental studies; Fracture tolerance; Underbody blast loadings; Military environments ID OPERATION IRAQI FREEDOM; BRIGADE COMBAT TEAM; CORD-INJURY; EPIDEMIOLOGY; IMPACT; HEAD; ACCIDENTS; TRAUMA; COLUMN; CONFLICT AB Background: While cervical spine injury biomechanics reviews in motor vehicle and sports environments are available, there is a paucity of studies in military loadings. This article presents an analysis on the biomechanics and applications of cervical spine injury research with an emphasis on human tolerance for underbody blast loadings in the military. Methods: Following a brief review of published military studies on the occurrence and identification of field trauma, postmortem human subject investigations are described using whole body, intact head neck complex, osteo-ligamentous cervical spine with head, subaxial cervical column, and isolated segments subjected to differing types of dynamic loadings (electrohydraulic and pendulum impact devices, free-fall drops). Findings: Spine injuries have shown an increasing trend over the years, explosive devices are one of the primary causal agents and trauma is attributed to vertical loads. Injuries, mechanisms and tolerances are discussed under these loads. Probability-based injury risk curves are included based on loading rate, direction and age. Interpretation: A unique advantage of human cadaver tests is the ability to obtain fundamental data to delineate injury biomechanics and establish human tolerance and injury criteria. Definitions of tolerances of the spine under vertical loads based on injuries have implications in clinical and biomechanical applications. Primary outputs such as forces and moments can be used to derive secondary variables such as the neck injury criterion. Implications are discussed for designing anthropomorphic test devices that may be used to predict injuries in underbody blast environments and improve the safety of military personnel. Published by Elsevier Ltd. C1 [Yoganandan, Narayan; Stemper, Brian D.; Pintar, Frank A.; Maiman, Dennis J.] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [McEntire, B. Joseph; Chancey, Valeta Carol] US Army Aeromed Res Lab, Ft Rucker, AL USA. RP Yoganandan, N (reprint author), Med Coll Wisconsin, Dept Neurosurg, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA. EM yoga@mcw.edu FU VA Medical Research [W81XWH-12-2-0041, W81XWH-10-2-0065] FX This study was supported in part by VA Medical Research, W81XWH-12-2-0041 and W81XWH-10-2-0065. The views expressed in this manuscript are those of the authors and do not reflect official policy or position of the Department of the Army, Department of Defense or the U.S. Government. NR 58 TC 7 Z9 8 U1 0 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 J9 CLIN BIOMECH JI Clin. Biomech. PD JUL PY 2013 VL 28 IS 6 BP 602 EP 609 DI 10.1016/j.clinbiomech.2013.05.007 PG 8 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA 225PT UT WOS:000324975500002 PM 23796847 ER PT J AU Hamilton, JB Deal, AM Moore, AD Best, NC Galbraith, KV Muss, H AF Hamilton, Jill B. Deal, Allison M. Moore, Angelo D. Best, Nakia C. Galbraith, Kayoll V. Muss, Hyman TI Psychosocial Predictors of Depression Among Older African American Patients With Cancer SO ONCOLOGY NURSING FORUM LA English DT Article ID QUALITY-OF-LIFE; PROSTATE-CANCER; BREAST-CANCER; COLORECTAL-CANCER; LUNG-CANCER; SELF-BLAME; SURVIVORS; ADULTS; SYMPTOMS; HEALTH AB Purpose/Objectives: To determine whether psychosocial factors predict depression among older African American patients with cancer. Design: A descriptive correlational study. Setting: Outpatient oncology clinic of a National Cancer Institute designated cancer center in the southeastern United States. Sample: African American patients with cancer aged 50-88 years. Methods: Fisher's exact and Wilcoxon rank-sum tests were used to evaluate differences between patients who were possibly depressed (Geriatric Depression Scale) or not. Multivariate linear regression statistics were used to identify the psychosocial factors that predicted higher depression scores. Education and gender were included as covariates. Main Research Variables: Religiosity, emotional support, collectivism, perceived stigma, and depression. Findings: Participants (N = 77) had a mean age of 61 years (SD = 8.4), and a majority were well-educated, insured, religiously affiliated, and currently in treatment. Participants who were in the lowest income category, not married, or male had higher depression scores. The multivariable model consisting of organized religion, emotional support, collectivism, education, and gender explained 52% (adjusted R-2) of the variation in depression scores. Stigma became insignificant in the multivariable model. Conclusions: Psychosocial factors are important predictors of depression. Emotional support and organized religious activities may represent protective factors against depression, whereas collectivism may increase their risk. Implications for Nursing: Nurses need to be particularly aware of the potential psychological strain for patients with collectivist values, experienced stigma, disruptions in church attendance, and lack of emotional support. In addition, the treatment plans for these patients should ensure that family members are knowledgeable about cancer, its treatment, and side effects so they are empowered to meet support needs. Knowledge Translation: Among older African American patients with cancer, emotional support and reassurance from family and friends that they will not abandon them decreases the likelihood of depressive symptoms and minimizes the impact of stigmatizing responses, but the perception that the illness is placing a strain on the family increases the likelihood of such symptoms. Emotional support likely is a stronger predictor of depressive symptoms than religious service attendance. C1 [Hamilton, Jill B.; Best, Nakia C.; Galbraith, Kayoll V.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27515 USA. [Deal, Allison M.; Muss, Hyman] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Moore, Angelo D.] Tripler Army Med Ctr, US Army, Honolulu, HI 96859 USA. RP Hamilton, JB (reprint author), Univ N Carolina, Sch Nursing, Chapel Hill, NC 27515 USA. EM jhamilto@email.unc.edu FU University Cancer Research Fund of the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill FX Jill B. Hamilton, PhD, is an associate professor in the School of Nursing and Allison M. Deal, MS, is a biostatistician in the Lineberger Comprehensive Cancer Center, both at the University of North Carolina at Chapel Hill; LTC Angelo D. Moore, PhD, is a nurse scientist for the U.S. Army at Tripler Army Medical Center in Honolulu, HI; and Nakia C. Best, MSN, and Kayoll V. Galbraith, BSN, are doctoral students in the School of Nursing and Hyman Muss, MD, is a professor in the Lineberger Comprehensive Cancer Center, all at the University of North Carolina at Chapel Hill. This research was funded, in part, by the University Cancer Research Fund of the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill. Assistance was provided by the Biostatistics Department in the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. government. Hamilton can be reached at jhamilto@email.unc.edu, with copy to the editor at ONF Editor@ons.org (Submitted September 2012. Accepted for publication October 2, 2012.) NR 60 TC 4 Z9 4 U1 3 U2 8 PU ONCOLOGY NURSING SOC PI PITTSBURGH PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA SN 0190-535X J9 ONCOL NURS FORUM JI Oncol. Nurs. Forum PD JUL PY 2013 VL 40 IS 4 BP 394 EP 402 DI 10.1188/13.ONF.394-402 PG 9 WC Oncology; Nursing SC Oncology; Nursing GA 220EO UT WOS:000324565200012 PM 23803271 ER PT J AU Hohmann, MG Just, MG Frank, PJ Wall, WA Gray, JB AF Hohmann, Matthew G. Just, Michael G. Frank, Peter J. Wall, Wade A. Gray, Janet B. TI Prioritizing Invasive Plant Management with Multi-Criteria Decision Analysis SO INVASIVE PLANT SCIENCE AND MANAGEMENT LA English DT Article DE Analytic Hierarchy Process (AHP); management prioritization; multi-species management strategies; spatially explicit ID SENSITIVITY-ANALYSIS; VASCULAR FLORA; SPREAD; GIS; LANDSCAPE; ECOSYSTEM; INVADERS; CRITERIA; HABITAT; SPACE AB Prioritizing management of invasive plants is important for large land management entities, such as federal and state public land stewards, because management resources are limited and multiple land uses and management objectives are differentially impacted. Management decisions also have important consequences for the likelihood of success and ultimate cost of control efforts. We applied multi-criteria decision analysis methods in a geographic information system using natural resource and land use data from Fort Bragg, North Carolina. Landscape-scale prioritization was based on a hierarchical model designed to increase invasive plant management efficiencies and reduce the risk of impacts to key installation management goals, such as training-land management and protected species conservation. We also applied spatial sensitivity analyses to evaluate the robustness of the prioritization to perturbations of the model weights, which were used to describe the relative importance of different elements of the hierarchical model. Based on stakeholders' need for confidence in making management investments, we incorporated the results of the sensitivity analysis into the decision-making process. We identified high-priority sites that were minimally affected by the weight perturbations as being suitable for up-front management and evaluated how adopting this strategy affected management area, locations, and costs. We found that incorporating the results of the sensitivity analysis led to a reduced management area, different target locations, and lower costs for an equal area managed. Finally, we confirmed the distinctiveness of the approach by comparing this same subset of prioritized sites with locations representing species-centric strategies for three invasive plants and their aggregate distribution. By supplying pragmatic information about the localized effects of weighting uncertainty, spatial sensitivity analyses enhanced the invasive plant management decision-making process and increased stakeholder confidence. C1 [Hohmann, Matthew G.; Wall, Wade A.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Just, Michael G.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Frank, Peter J.] Invas Species Management Inc, Vass, NC 28394 USA. [Gray, Janet B.] Endangered Species Branch, Ft Bragg, NC 28310 USA. RP Hohmann, MG (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM matthew.g.hohmann@us.army.mil OI Just, Michael/0000-0003-2493-9269 FU U.S. Army Corps of Engineers, Engineer Research and Development Center FX This research was funded by the U.S. Army Corps of Engineers, Engineer Research and Development Center. We thank the Fort Bragg Environmental Division Staff for providing data and valuable input. We also thank Naicong Li, Peter J. Murphy, Arika Ligmann-Zielinska, and two anonymous reviewers for helpful discussions and comments. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 53 TC 1 Z9 1 U1 5 U2 46 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 1939-7291 J9 INVAS PLANT SCI MANA JI Invasive Plant Sci. Manag. PD JUL-SEP PY 2013 VL 6 IS 3 BP 339 EP 351 DI 10.1614/IPSM-D-11-00080.1 PG 13 WC Plant Sciences SC Plant Sciences GA 217GG UT WOS:000324346900003 ER PT J AU Myers, GA Muhajir, MA AF Myers, Garth Andrew Muhajir, Makame A. TI "Wiped From the Map of the World'? Zanzibar, Critical Geopolitics and Language SO GEOPOLITICS LA English DT Article AB This essay uses the case of Zanzibar in its complicated relationship with the United Republic of Tanzania (of which it is a part) as a lens on debates in political geography on empirical and conceptual approaches to critical geopolitics. We test the veracity of a multi-faceted critical geopolitics in the contemporary public contestation of Zanzibar's place in the United Republic from 2008-2012. We analyze Tanzanian media, the speech acts of Tanzanian leaders, and the key events and processes related to what is termed the Zanzibar problem' during the selected years, to make two points about a critical geopolitics approach: to strengthen critical geopolitics by broadening the analysis of language to engage political acts and languages beyond the Global North; and taking subaltern geopolitics' more seriously via engagement with critical geopolitical voices on discourses, events and processes from the Global South. C1 [Myers, Garth Andrew] Trinity Coll, Ctr Urban & Global Studies, Hartford, CT 06106 USA. [Muhajir, Makame A.] US Mil Acad, West Point, NY 10996 USA. RP Myers, GA (reprint author), Trinity Coll, Ctr Urban & Global Studies, 300 Summit St, Hartford, CT 06106 USA. EM garth.myers@trincoll.edu NR 49 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1465-0045 J9 GEOPOLITICS JI Geopolitics PD JUL 1 PY 2013 VL 18 IS 3 BP 662 EP 681 DI 10.1080/14650045.2013.769962 PG 20 WC Geography; Political Science SC Geography; Government & Law GA 204ZF UT WOS:000323409100008 ER PT J AU Sun, PF Garcia, J Comach, G Vahey, MT Wang, ZN Forshey, BM Morrison, AC Sierra, G Bazan, I Rocha, C Vilcarromero, S Blair, PJ Scott, TW Camacho, DE Ockenhouse, CF Halsey, ES Kochel, TJ AF Sun, Peifang Garcia, Josefina Comach, Guillermo Vahey, Maryanne T. Wang, Zhining Forshey, Brett M. Morrison, Amy C. Sierra, Gloria Bazan, Isabel Rocha, Claudio Vilcarromero, Stalin Blair, Patrick J. Scott, Thomas W. Camacho, Daria E. Ockenhouse, Christian F. Halsey, Eric S. Kochel, Tadeusz J. TI Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID ANTIBODY-DEPENDENT ENHANCEMENT; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; HEMORRHAGIC-FEVER; PERIPHERAL-BLOOD; VIRUS-INFECTION; TRANSCRIPT ABUNDANCE; IMMUNE ACTIVATION; NATURAL-HISTORY; PLASMA LEAKAGE AB Background: Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, especially during the early days, remains poorly characterized. Early diagnostic markers for DHF are also lacking. Methodology/Principal Findings: In this study, we investigated host gene expression in a cohort of DENV-infected subjects clinically diagnosed as DF (n = 51) and DHF (n = 13) from Maracay, Venezuela. Blood specimens were collected daily from these subjects from enrollment to early defervescence and at one convalescent time-point. Using convalescent expression levels as baseline, two distinct groups of genes were identified: the "early" group, which included genes associated with innate immunity, type I interferon, cytokine-mediated signaling, chemotaxis, and complement activity peaked at day 0-1 and declined on day 3-4; the second "late" group, comprised of genes associated with cell cycle, emerged from day 4 and peaked at day 5-6. The up-regulation of innate immune response genes coincided with the down-regulation of genes associated with viral replication during day 0-3. Furthermore, DHF patients had lower expression of genes associated with antigen processing and presentation, MHC class II receptor, NK and T cell activities, compared to that of DF patients. These results suggested that the innate and adaptive immunity during the early days of the disease are vital in suppressing DENV replication and in affecting outcome of disease severity. Gene signatures of DHF were identified as early as day 1. Conclusions/Significance: Our study reveals a broad and dynamic picture of host responses in DENV infected subjects. Host response to DENV infection can now be understood as two distinct phases with unique transcriptional markers. The DHF signatures identified during day 1-3 may have applications in developing early molecular diagnostics for DHF. C1 [Sun, Peifang; Kochel, Tadeusz J.] Naval Med Res Ctr, Silver Spring, MD USA. [Sun, Peifang; Wang, Zhining] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Garcia, Josefina; Forshey, Brett M.; Morrison, Amy C.; Bazan, Isabel; Rocha, Claudio; Vilcarromero, Stalin; Halsey, Eric S.] US Naval Med Res Unit 6, Lima, Peru. [Comach, Guillermo; Sierra, Gloria; Camacho, Daria E.] Inst Invest Biomed Univ Carabobo BIOMED UC, Lab Reg Diagnost & Invest Dengue & Otras Enfermed, Maracay, Venezuela. [Vahey, Maryanne T.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Morrison, Amy C.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Blair, Patrick J.] Amer Embassy Singapore, US Naval Med Res Unit Pacific 2, Singapore, Singapore. [Ockenhouse, Christian F.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Sun, PF (reprint author), Naval Med Res Ctr, Silver Spring, MD USA. EM peifang.sun@med.navy.mil OI Vilcarromero, Stalin/0000-0002-9097-0638 FU US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Center [847705.82000.25GB.B0016]; MIDRP [S0147_07_LI] FX This study was funded by the US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Center, WORK UNIT NUMBER: 847705.82000.25GB.B0016. The work was also supported by MIDRP funding: S0147_07_LI. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 16 Z9 17 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUL PY 2013 VL 7 IS 7 AR e2298 DI 10.1371/journal.pntd.0002298 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 190EJ UT WOS:000322321500015 PM 23875036 ER PT J AU Pasiakos, SM McClung, JP AF Pasiakos, Stefan M. McClung, James P. TI miRNA Analysis for the Assessment of Exercise and Amino Acid Effects on Human Skeletal Muscle SO ADVANCES IN NUTRITION LA English DT Review ID RESISTANCE EXERCISE; PROTEIN-SYNTHESIS; MICRORNA EXPRESSION; WEIGHT-LOSS; BODY-COMPOSITION; ADULT WOMEN; MTORC1; MASS; CARBOHYDRATE; PATHWAYS AB The study of micro RNA (miRNA) expression and function, a largely unexplored area of human muscle biology, may provide novel data regarding the development of targeted approaches that optimize skeletal muscle responses to exercise and amino add manipulations. miRNAs are ubiquitously expressed, small noncoding RNAs that modulate post-transcriptional gene expression. Quantifying miRNA expression and predicting function as regulators of both single targets and complex networks is technically challenging and requires a combined approach of bioinformatics, molecular, and systems biology. Recent evidence suggests that the expression of muscle-specific miRNAs (myomirs), including miR-1, miR-133a/b, miR-206, and miR-499, is modulated by essential amino acid ingestion, endurance exercise, and endurance exercise training. The expression of miRNAs has also been implicated in the anabolic intracellular signaling and muscle hypertrophic response associated with resistance exercise training. Although these findings are intriguing, comprehensive human trials assessing functional outcomes associated with changes in miRNA expression in response to exercise and nutrition interventions have not been conducted. This article reviews the current understanding of miRNA biology and includes analytical techniques used to detect miRNA expression and methods to predict function. The intent is to provide the framework for future research studies that use miRNA analysis in an effort to elucidate optimal exercise and nutritional countermeasures for the prevention of muscle loss. C1 [Pasiakos, Stefan M.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. EM stefan.pasiakos@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU United States Army Military Research and Material Command FX Supported by United States Army Military Research and Material Command. NR 38 TC 4 Z9 4 U1 1 U2 17 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 J9 ADV NUTR JI Adv. Nutr. PD JUL PY 2013 VL 4 IS 4 BP 412 EP 417 DI 10.3945/an.113.003699 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 201KR UT WOS:000323141000002 PM 23858090 ER PT J AU Wohlgemut, JM Morrison, JJ Apodaca, AN Egan, G Sponseller, PD Driver, CP Jansen, JO AF Wohlgemut, Jared M. Morrison, Jonathan J. Apodaca, Amy N. Egan, Gerry Sponseller, Paul D. Driver, Christopher P. Jansen, Jan O. TI Demographic and geographical characteristics of pediatric trauma in Scotland SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE Trauma; Paediatric; Trauma system; Demographic; Scotland; Surgery; Emergency ID MORTALITY; CARE; INJURY AB Background: Trauma systems reduce mortality and improve functional outcomes. The aim of this study was to analyse the demographic and geospatial characteristics of pediatric trauma patients in Scotland, and determine the level of destination healthcare facility which injured children are taken to, to determine the need for, and general feasibility, of developing a pediatric trauma system for Scotland. Methods: Retrospective analysis of incidents involving children aged 1-14 attended to by the Scottish Ambulance Service between 1 November 2008 and 31 October 2010. A subgroup with physiological derangement was defined. Incident location postcode was used to determine incident location by health board region, rurality and social deprivation. Destination healthcare facility was classified into one of six categories. Results: Of 10,759 incidents, 72.3% occurred in urban areas and 5.8% in remote areas. Incident location was associated with socioeconomic deprivation. Of the patients, 11.6% were taken to a pediatric hospital with pediatric intensive care facilities, 21.8% to a pediatric hospital without pediatric intensive care service, and 50.2% to an adult large general hospital without pediatric surgical service. Conclusions: The majority of incidents involving children with injuries occurred in urban areas. Half were taken to a hospital without pediatric surgical service. There was no difference between children with normal and deranged physiology. (C) 2013 Elsevier Inc. All rights reserved. C1 [Wohlgemut, Jared M.] Univ Aberdeen, Sch Med & Dent, Aberdeen AB25 2ZD, Scotland. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Apodaca, Amy N.] US Army Inst Surg Res, San Antonio, TX USA. [Egan, Gerry] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. [Sponseller, Paul D.] Johns Hopkins Univ Hosp, Bloomberg Childrens Ctr, Dept Orthopaed Surg, Div Pediat, Baltimore, MD 21287 USA. [Driver, Christopher P.] Royal Aberdeen Childrens Hosp, Dept Paediat Surg, Aberdeen AB25 2ZG, Scotland. [Jansen, Jan O.] Aberdeen Royal Infirm, Dept Surg, Ward 34, Aberdeen AB25 2ZN, Scotland. [Jansen, Jan O.] Aberdeen Royal Infirm, Dept Intens Care Med, Ward 34, Aberdeen AB25 2ZN, Scotland. RP Jansen, JO (reprint author), Aberdeen Royal Infirm, Dept Surg, Ward 34, Foresterhill, Aberdeen AB25 2ZN, Scotland. EM j.o.jansen@gmx.com OI Morrison, Jonathan/0000-0001-7462-8456 NR 27 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD JUL PY 2013 VL 48 IS 7 BP 1593 EP 1597 DI 10.1016/j.jpedsurg.2013.03.060 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 201TP UT WOS:000323166200026 PM 23895978 ER PT J AU Patterson, TJ Brennan, MB Schobitz, RP AF Patterson, Thomas J. Brennan, Michael B. Schobitz, Richard P. TI Concurrent and Co-Located Early Intervention for Concussion and Acute Stress Reaction SO PSYCHIATRIC ANNALS LA English DT Article ID TRAUMATIC BRAIN-INJURY; COMBAT STRESS; DISORDER; SOLDIERS C1 [Patterson, Thomas J.; Brennan, Michael B.; Schobitz, Richard P.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Schobitz, RP (reprint author), Dept Behav Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Richard.schobitz@us.army.mil NR 25 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD JUL PY 2013 VL 43 IS 7 BP 313 EP 317 DI 10.3928/00485713-20130703-05 PG 5 WC Psychiatry SC Psychiatry GA 205HH UT WOS:000323433600005 ER PT J AU Hoge, CW AF Hoge, Charles W. TI Integrating Evidence-Based Treatments for PTSD with CAM Practices SO PSYCHIATRIC ANNALS LA English DT Editorial Material C1 [Hoge, Charles W.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Hoge, Charles W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Hoge, CW (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Washington, DC 20307 USA. EM charles.hoge@us.army.mil NR 3 TC 1 Z9 1 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD JUL PY 2013 VL 43 IS 7 BP 338 EP 339 DI 10.3928/00485713-20130703-10 PG 2 WC Psychiatry SC Psychiatry GA 205HH UT WOS:000323433600010 ER PT J AU Bisdikian, C Kaplan, LM Srivastava, MB AF Bisdikian, Chatschik Kaplan, Lance M. Srivastava, Mani B. TI On the Quality and Value of Information in Sensor Networks SO ACM TRANSACTIONS ON SENSOR NETWORKS LA English DT Article DE Performance; Quality of information; value of information; QoI; VoI; Internet of things; IoT; analytic hierarchy process; AHP; provenance; metadata; information systems; sensor information fusion ID ANALYTIC HIERARCHY PROCESS; DECISION; MECHANISMS; SYSTEMS AB The increasing use of sensor-derived information from planned, ad-hoc, and/or opportunistically deployed sensor networks provides enhanced visibility to everyday activities and processes, enabling fast-paced data-to-decision in personal, social, civilian, military, and business contexts. The value that information brings to this visibility and ensuing decisions depends on the quality characteristics of the information gathered. In this article, we highlight, refine, and extend upon our past work in the areas of quality and value of information (QoI and VoI) for sensor networks. Specifically, we present and elaborate on our two-layer QoI/VoI definition, where the former relates to context-independent aspects and the latter to context-dependent aspects of an information product. Then, we refine our taxonomy of pertinent QoI and VoI attributes anchored around a simple ontological relationship between the two. Finally, we introduce a framework for scoring and ranking information products based on their VoI attributes using the analytic hierarchy multicriteria decision process, illustrated via a simple example. C1 [Kaplan, Lance M.] USA, Res Lab, Adelphi, MD USA. [Srivastava, Mani B.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Bisdikian, C (reprint author), IBM Corp, TJ Watson Res Ctr, Yorktown Hts, NY USA. EM bisdik@us.ibm.com; lkaplan@ieee.org; mbs@ee.ucla.edu FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX Research was sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence under Agreement W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U. S. Army Research Laboratory, the U. S. Government, the U. K. Ministry of Defence or the U. K. Government. The U. S. and U. K. Governments are authorized to reproduce and distribute reprints for Government purposes not with standing any copyright notation herein. NR 53 TC 15 Z9 15 U1 0 U2 28 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1550-4859 EI 1550-4867 J9 ACM T SENSOR NETWORK JI ACM Trans. Sens. Netw. PD JUL PY 2013 VL 9 IS 4 AR 48 DI 10.1145/2489253.2489265 PG 26 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 195YQ UT WOS:000322740200012 ER PT J AU Zhu, YJ Han, XG Xu, YH Liu, YH Zheng, SY Xu, K Hu, LB Wang, CS AF Zhu, Yujie Han, Xiaogang Xu, Yunhua Liu, Yihang Zheng, Shiyou Xu, Kang Hu, Liangbing Wang, Chunsheng TI Electrospun Sb/C Fibers for a Stable and Fast Sodium-Ion Battery Anode SO ACS NANO LA English DT Article DE electrospinning; antimony; anode; sodium ion battery ID IN-SITU MEASUREMENTS; HIGH-CAPACITY; LOW-COST; LITHIUM BATTERIES; RATE CAPABILITY; THIN-FILMS; CARBON; INSERTION; CHALLENGES; CATHODE AB Sodium-ion batteries (SIBs) are considered a top alternative to lithium-ion batteries (LIBs) for large-scale renewable energy storage units due to their low cost and the abundance of sodium-bearing precursors in the earth's mineral deposits. However, the development of anode materials for SIBs to date has been mainly limited to carbonaceous materials with minimal research devoted to high capacity alloy-based materials. In this study, an antimony (Sb)/carbon (C) electrode with similar to 30 nm Sb nanoparticles (NPs) uniformly encapsulated in interconnecting one-dimensional (1D) 400 nm carbon fibers (denoted as SbNP@C) was fabricated using a simple and scalable electrospinning method. This binder-free, current collector-free SbNP@C electrode demonstrated high capacity and stable long-term cycling performance at various current densities. The SbNP@C electrode showed an initial total capacity of 422 mAh/g(electrode) and retained 350 mAh/g(electrode) after 300 deep charge-discharge cycles under 100 mA/g(sb). Moreover, because of the efficient 1D sodium-ion transport pathway and the highly conductive network of SbNP@C, the electrode preserved high overall capacities even when cycled at high currents, extending its usability to high power applications. C1 [Zhu, Yujie; Xu, Yunhua; Liu, Yihang; Zheng, Shiyou; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Han, Xiaogang; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM cswang@umd.edu RI Han, Xiaogang/D-6430-2015; Liu, Yihang/E-6958-2013; Wang, Chunsheng/H-5767-2011; Zheng, Shiyou/D-3645-2012; Hu, Liangbing/N-6660-2013 OI Han, Xiaogang/0000-0002-4785-6506; Liu, Yihang/0000-0002-2491-9439; Wang, Chunsheng/0000-0002-8626-6381; FU National Science Foundation [CBET0933228] FX The authors acknowledge the financial support of the National Science Foundation under Contract No. CBET0933228 (Dr. M. Burka, Program Director) and the technical support of the Nano Center at the University of Maryland. NR 37 TC 205 Z9 205 U1 76 U2 527 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD JUL PY 2013 VL 7 IS 7 BP 6378 EP 6386 DI 10.1021/nn4025674 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 191MO UT WOS:000322417400086 PM 23802576 ER PT J AU Burk, RC AF Burk, Roger Chapman TI Closed-Form Approximation of Revisit Rate for Low-Altitude Satellites SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID GENETIC ALGORITHM; ORBIT DESIGN AB For many applications of low-altitude spacecraft, it is important to know how often the spacecraft revisits a given target. Average revisits per day can be calculated for a given scenario using astrodynamic software, but that approach can be tedious if a large number of cases are to be compared. This paper develops a closed-form, continuous, and piecewise differentiable function that gives average revisits per day as a function of orbit altitude, orbit inclination, target latitude, and minimum required elevation. The function is compared with the results of astrodynamic simulations and shown to be accurate to within 0.08 passes per day and 1% in almost all cases. It allows instant calculation of an excellent approximation of this important performance parameter and could be used as part of an optimization routine. The convenience and flexibility provided by this function are demonstrated in a series of charts showing passes per day as a function of one, two, and three variables. The function assumes a circular orbit; the sensitivity of the result to eccentricity is explored using astrodynamic simulations and is found to decrease by 5.3% as eccentricity increases to 0.07 for a typical case. C1 US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Burk, RC (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. NR 16 TC 1 Z9 1 U1 1 U2 1 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JUL-AUG PY 2013 VL 50 IS 4 BP 872 EP 883 DI 10.2514/1.A32275 PG 12 WC Engineering, Aerospace SC Engineering GA 197KS UT WOS:000322850700017 ER PT J AU Frattalone, AR Ling, GSF AF Frattalone, Anthony R. Ling, Geoffrey S. F. TI Moderate and Severe Traumatic Brain Injury: Pathophysiology and Management SO NEUROSURGERY CLINICS OF NORTH AMERICA LA English DT Article DE Traumatic brain injury; Clinical practice guidelines; Head injury; Concussion; Coma; ICP (intracranial pressure); OPP (cerebral perfusion pressure) ID SEVERE HEAD-INJURY; CEREBRAL PERFUSION-PRESSURE; RAPID-SEQUENCE INTUBATION; RANDOMIZED-CONTROLLED-TRIAL; INTENSIVE-CARE-UNIT; GLASGOW COMA SCALE; INTRACRANIAL-PRESSURE; EMERGENCY-DEPARTMENT; FLUID RESUSCITATION; TRACHEAL INTUBATION AB Traumatic brain injury (TBI) is a serious disorder that is all too common. TBI ranges in severity from mild concussion to a severe life-threatening state. Across this spectrum, rational therapeutic approaches exist. Early identification that TBI has occurred in a patient is paramount to optimal outcome. Proper clinical management should be instituted as soon as possible by appropriately trained medical providers. More seriously injured patients must be triaged to advanced care centers. It is only through this rational approach to TBI that patients may expect to achieve optimal clinical and functional outcome. C1 [Frattalone, Anthony R.; Ling, Geoffrey S. F.] Johns Hopkins Med Inst, Div Neurocrit Care, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA. [Frattalone, Anthony R.; Ling, Geoffrey S. F.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Ling, GSF (reprint author), US Army, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM geoffrey.ling@usuhs.edu NR 78 TC 14 Z9 14 U1 2 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1042-3680 J9 NEUROSURG CLIN N AM JI Neurosurg. Clin. N. Am. PD JUL PY 2013 VL 24 IS 3 BP 309 EP + DI 10.1016/j.nec.2013.03.006 PG 12 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 191NY UT WOS:000322421100002 PM 23809027 ER PT J AU Ranade, R Li, VC Stults, MD Rushing, TS Roth, J Heard, WF AF Ranade, Ravi Li, Victor C. Stults, Michael D. Rushing, Todd S. Roth, Jason Heard, William F. TI Micromechanics of High-Strength, High-Ductility Concrete SO ACI MATERIALS JOURNAL LA English DT Article DE high-ductility concrete; high-performance cementitious composite; high-strength concrete; micromechanics ID COMPOSITE PVA-ECC; MATRIX; BEHAVIOR; FIBERS AB This paper reports the microscale investigation of a new fiber-reinforced cementitious composite, high-strength, high-ductility concrete (HSHDC), which possesses a rare combination of very high compressive strength (166 MPa [24.1 ksi]) and very high tensile ductility (3.4% strain capacity). The investigation involved experimental determination of fiber/matrix interaction properties using single-fiber pullout tests. A new mechanism of inclination-dependent hardening in fiber pullout unique for a high-strength cementitious matrix-is discovered. The existing fiber-pullout analytical model for strain-hardening cementitious composites (SHCCs) is modified to incorporate the new mechanism. The modeled fiber-pullout behavior is used in a scale-linking model to compute the crack bridging (sigma-delta) relation of HSHDC, which is also empirically verified through single-crack tests. The sigma-delta relation of HSHDC satisfies the micromechanics-based necessary strength and energy conditions of steady-state flat crack propagation that prevent localized fracture. The microscale investigation of HSHDC in this research thus demonstrates the rational basis for its design combining both high compressive strength and high tensile ductility. C1 [Ranade, Ravi; Li, Victor C.] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. [Stults, Michael D.] Tuan & Robinson Struct Engn Inc, San Francisco, CA USA. [Rushing, Todd S.] USA, Erdc, Vicksburg, MS USA. [Rushing, Todd S.] Univ So Mississippi, Hattiesburg, MS 39406 USA. [Roth, Jason] Univ Calif Los Angeles, Los Angeles, CA USA. [Heard, William F.] Vanderbilt Univ, Nashville, TN 37235 USA. RP Ranade, R (reprint author), Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. RI Ranade, Ravi/I-6387-2013; OI Ranade, Ravi/0000-0001-6030-8371; Li, Victor/0000-0002-8678-3493 FU University of Michigan from the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS [W912HZ-08-C-0056] FX This research at the University of Michigan was supported by a research contract (W912HZ-08-C-0056) from the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS. Helpful discussions with T. Slawson (ERDC) and T. Cummins (ERDC) are gratefully acknowledged. The material suppliers: Honeywell, Lafarge, Elkem, US Silica, and WR Grace are duly acknowledged for providing the materials used in this research. Permission to publish was granted by Director, Geotechnical and Structures Laboratory at ERDC. NR 27 TC 3 Z9 3 U1 7 U2 25 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-325X EI 1944-737X J9 ACI MATER J JI ACI Mater. J. PD JUL-AUG PY 2013 VL 110 IS 4 BP 375 EP 384 PG 10 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA 193MK UT WOS:000322563700003 ER PT J AU Ranade, R Li, VC Stults, MD Heard, WF Rushing, TS AF Ranade, Ravi Li, Victor C. Stults, Michael D. Heard, William F. Rushing, Todd S. TI Composite Properties of High-Strength, High-Ductility Concrete SO ACI MATERIALS JOURNAL LA English DT Article DE engineered cementitious composites; high-ductility concrete; high-performance cementitious composite; high-strength concrete ID ENGINEERED CEMENTITIOUS COMPOSITES; PVA-ECC; PERFORMANCE; DISPERSION; BEHAVIOR; FIBERS AB A new fiber-reinforced cementitious composite-high-strength, high-ductility concrete (HSHDC)-has been developed at the University of Michigan, Ann Arbor, in collaboration with the U.S. Army Engineer Research and Development Center, Vicksburg, MS. The micromechanics-based design of HSHDC resulted in a unique combination of ultra-high compressive strength (166 MPa [24 ksi]), tensile ductility (3.4%), and high specific energy absorption under direct tension (greater than 300 kJ/m(3) [6270 lb-ft/ft(3)]). The material design approach and mechanical property characterization of HSHDC under direct tension, split tension, third-point flexure, and uniaxial compression loading, along with its density and fresh properties, are reported in this paper. C1 [Ranade, Ravi; Li, Victor C.] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. [Stults, Michael D.] Tuan & Robinson Struct Engineers Inc, San Francisco, CA USA. [Rushing, Todd S.] US Army, Vicksburg, MS USA. [Rushing, Todd S.] Dev Ctr ERDC, Vicksburg, MS USA. RP Ranade, R (reprint author), Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. RI Ranade, Ravi/I-6387-2013; OI Ranade, Ravi/0000-0001-6030-8371; Li, Victor/0000-0002-8678-3493 FU U.S. Army ERDC, Vicksburg, MS [W912HZ-08-C-0056] FX This research at the University of Michigan was supported by a research contract (W912HZ-08-C-0056) from the U.S. Army ERDC, Vicksburg, MS. Helpful discussions with E. O'Neil, J. Roth, T. Slawson, and T. Cummins of ERDC are gratefully acknowledged. The authors also acknowledge the material suppliers Honeywell, Lafarge, US Silica, Elkem, and WR Grace, for providing materials for this research program. Permission to publish was granted by Director, Geotechnical and Structures Laboratory at ERDC. NR 38 TC 10 Z9 10 U1 0 U2 25 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-325X EI 1944-737X J9 ACI MATER J JI ACI Mater. J. PD JUL-AUG PY 2013 VL 110 IS 4 BP 413 EP 422 PG 10 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA 193MK UT WOS:000322563700007 ER PT J AU Taylor, SL Wahl-Jensen, V Copeland, AM Jahrling, PB Schmaljohn, CS AF Taylor, Shannon L. Wahl-Jensen, Victoria Copeland, Anna Maria Jahrling, Peter B. Schmaljohn, Connie S. TI Endothelial Cell Permeability during Hantavirus Infection Involves Factor XII-Dependent Increased Activation of the Kallikrein-Kinin System SO PLOS PATHOGENS LA English DT Article ID SYRIAN-HAMSTER MODEL; PULMONARY SYNDROME; ANDES VIRUS; HEMORRHAGIC-FEVER; GROWTH-FACTOR; NITRIC-OXIDE; VE-CADHERIN; HEREDITARY ANGIOEDEMA; INTRINSIC PATHWAY; VESSEL FORMATION AB Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) are diseases caused by hantavirus infections and are characterized by vascular leakage due to alterations of the endothelial barrier. Hantavirus-infected endothelial cells (EC) display no overt cytopathology; consequently, pathogenesis models have focused either on the influx of immune cells and release of cytokines or on increased degradation of the adherens junction protein, vascular endothelial (VE)-cadherin, due to hantavirus-mediated hypersensitization of EC to vascular endothelial growth factor (VEGF). To examine endothelial leakage in a relevant in vitro system, we co-cultured endothelial and vascular smooth muscle cells (vSMC) to generate capillary blood vessel-like structures. In contrast to results obtained in monolayers of cultured EC, we found that despite viral replication in both cell types as well as the presence of VEGF, infected in vitro vessels neither lost integrity nor displayed evidence of VE-cadherin degradation. Here, we present evidence for a novel mechanism of hantavirus-induced vascular leakage involving activation of the plasma kallikrein-kinin system (KKS). We show that incubation of factor XII (FXII), prekallikrein (PK), and high molecular weight kininogen (HK) plasma proteins with hantavirus-infected EC results in increased cleavage of HK, higher enzymatic activities of FXIIa/kallikrein (KAL) and increased liberation of bradykinin (BK). Measuring cell permeability in real-time using electric cell-substrate impedance sensing (ECIS), we identified dramatic increases in endothelial cell permeability after KKS activation and liberation of BK. Furthermore, the alterations in permeability could be prevented using inhibitors that directly block BK binding, the activity of FXIIa, or the activity of KAL. Lastly, FXII binding and autoactivation is increased on the surface of hantavirus-infected EC. These data are the first to demonstrate KKS activation during hantavirus infection and could have profound implications for treatment of hantavirus infections. C1 [Taylor, Shannon L.; Copeland, Anna Maria; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Wahl-Jensen, Victoria; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Ft Detrick, MD USA. RP Schmaljohn, CS (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. EM Connie.Schmaljohn@us.army.mil FU Independent Laboratory In-House Research (ILIR) [1591244] FX This work was sponsored by an Independent Laboratory In-House Research (ILIR) grant, project number 1591244. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 53 TC 25 Z9 25 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUL PY 2013 VL 9 IS 7 AR e1003470 DI 10.1371/journal.ppat.1003470 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 190CX UT WOS:000322316700023 PM 23874198 ER PT J AU Reger, GM Durham, TL Tarantino, KA Luxton, DD Holloway, KM Lee, JA AF Reger, Greg M. Durham, Tracy L. Tarantino, Kerith A. Luxton, David D. Holloway, Kevin M. Lee, Jocelyn A. TI Deployed Soldiers' Reactions to Exposure and Medication Treatments for PTSD SO PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY LA English DT Article DE treatment preference; stigma; cognitive-behavioral therapy; prolonged exposure; virtual reality exposure ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; COMORBIDITY SURVEY REPLICATION; COGNITIVE-BEHAVIORAL THERAPY; PROLONGED EXPOSURE; VIRTUAL-REALITY; TREATMENT CHOICE; IRAQ; COMBAT; WOMEN AB Only a minority of service members with posttraumatic stress disorder (PTSD) access care despite growing availability of evidence-based and innovative treatments. Although preferences for military personnel have not been established, previous research on civilian populations with PTSD suggest treatment preferences for exposure-based treatments over medications. There are also unique stressors in the deployed environment that may impact treatment preferences, such as close living proximity to peers and leaders, and limited access to typical coping strategies. Soldiers deployed to Iraq (n = 174) were provided a written hypothetical scenario about difficulties after combat exposure and were provided descriptions of Prolonged Exposure (PE), virtual reality exposure (VRE), and FDA-approved medications for PTSD. Soldiers completed a Treatment Reactions Scale for each treatment type. Responses were significantly more favorable for both PE and VRE relative to medications (p < .001). Relative to both exposure therapies, soldiers reacted to medications with significantly stronger agreement to scales reflecting embarrassment/shame for seeking a particular form of treatment, negative occupational/career impact, and perceived debasement for seeking the treatment. Relative to PE, soldiers were significantly less willing to recommend medication treatment and had significantly less confidence/belief in the efficacy of medications. These findings can help inform provider education of treatment options and demonstrate the importance of considering patient reactions to a treatment plan, as preferences may impact adherence. C1 [Reger, Greg M.; Luxton, David D.; Holloway, Kevin M.; Lee, Jocelyn A.] Natl Ctr Telehlth & Technol, Joint Base Lewis McChord, Tacoma, WA 98431 USA. [Durham, Tracy L.] 212th Med Detachment Combat Stress Control, Ft Campbell, KY USA. [Tarantino, Kerith A.] 528th Med Detachment Combat Stress Control, Ft Bragg, NC USA. RP Reger, GM (reprint author), Natl Ctr Telehlth & Technol, Joint Base Lewis McChord, Tacoma, WA 98431 USA. EM greg.reger@us.army.mil NR 48 TC 8 Z9 8 U1 2 U2 40 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1942-9681 J9 PSYCHOL TRAUMA-US JI Psychol. Trauma PD JUL PY 2013 VL 5 IS 4 BP 309 EP 316 DI 10.1037/a0028409 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 189RT UT WOS:000322286700002 ER PT J AU Yan, GW McAndrew, L D'Andrea, EA Lange, G Santos, SL Engel, CC Quigley, KS AF Yan, Grace W. McAndrew, Lisa D'Andrea, Elizabeth A. Lange, Gudrun Santos, Susan L. Engel, Charles C. Quigley, Karen S. TI Self-Reported Stressors of National Guard Women Veterans Before and After Deployment: The Relevance of Interpersonal Relationships SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE women's health; veterans; survey research; quality of life ID MILITARY SEXUAL TRAUMA; COMBAT; WAR; CARE; RISK; IRAQ AB BACKGROUND: With their rapidly expanding roles in the military, women service members experience significant stressors throughout their deployment experience. However, there are few studies that examine changes in women Veterans' stressors before and after deployment. OBJECTIVE: This study examines the types of stressors women Veterans report before deployment, immediately after deployment, 3 months after deployment, and 1 year post-deployment. DESIGN: Descriptive data on reported stressors was collected at four time points of a longitudinal study (HEROES Project). Open-ended responses from the Coping Response Inventory (CRI) were coded into six possible major stressor categories for analysis. PARTICIPANTS: Seventy-nine Army National Guard and Reserve female personnel deploying to Operation Enduring Freedom (OFF)/Operation Iraqi Freedom (OIF) were surveyed prior to deployment. Of these participants, 35 women completed Phase 2, 41 completed Phase 3, and 48 completed Phase 4 of the study. KEY RESULTS: We identified six major stressor categories: (1) interpersonal (i.e., issues with family and/or friends), (2) deployment-related and military-related, (3) health concerns, (4) death of a loved one, (5) daily needs (i. e., financial/housing/transportation concerns), and (6) employment or school-related concerns. At all time points, interpersonal issues were one of the most common type of stressor for this sample. Daily needs concerns increased from 3 months post-deployment to 1 year post-deployment. CONCLUSIONS: Interpersonal concerns are commonly reported by women Veterans both before and after their combat experience, suggesting that this is a time during which interpersonal support is especially critical. We discuss implications, which include the need for a more coordinated approach to women Veterans' health care (e. g., greater community-based outreach), and the need for more and more accessible Veterans Affairs (VA) services to address the needs of female Veterans. (C) Society of General Internal Medicine 2012 C1 [Yan, Grace W.; McAndrew, Lisa; D'Andrea, Elizabeth A.; Lange, Gudrun; Santos, Susan L.] NJ War Related Illness & Injury Study Ctr, Dept Vet Affairs, E Orange, NJ USA. [McAndrew, Lisa; Lange, Gudrun] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA. [D'Andrea, Elizabeth A.] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Santos, Susan L.] Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA. [Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Washington, DC USA. [Engel, Charles C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Bethesda, MD USA. [Quigley, Karen S.] Edith Nourse Rogers Mem Vet Adm Hosp, Dept Vet Affairs, Bedford, MA 01730 USA. [Quigley, Karen S.] Northeastern Univ, Boston, MA 02115 USA. RP Yan, GW (reprint author), NJ War Related Illness Injury Study Ctr, Dept Vet Affairs, 385 Tremont Ave,Mailstop 129, E Orange, NJ 07018 USA. EM weiyin.yan@va.gov FU Department of Veterans Affairs, Health Services Research & Development Service [IIR 02-296]; NJ War Related Illness and Injury Study Center, the NJ REAP [REA 03-021]; Deployment Health Clinical Center, Walter Reed Army Medical Center FX This study was supported by grants from the Department of Veterans Affairs, Health Services Research & Development Service (IIR 02-296 to K. Quigley); the NJ War Related Illness and Injury Study Center, the NJ REAP (REA 03-021); and the Deployment Health Clinical Center, Walter Reed Army Medical Center. NR 20 TC 5 Z9 5 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2013 VL 28 SU 2 BP S549 EP S555 DI 10.1007/s11606-012-2247-6 PG 7 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 184RL UT WOS:000321910900012 PM 23807064 ER PT J AU Sanchez, LM Potrepka, DM Fox, GR Takeuchi, I Wang, K Bendersky, LA Polcawich, RG AF Sanchez, Luz M. Potrepka, Daniel M. Fox, Glen R. Takeuchi, Ichiro Wang, Ke Bendersky, Leonid A. Polcawich, Ronald G. TI Optimization of PbTiO3 seed layers and Pt metallization for PZT-based piezoMEMS actuators SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID THIN-FILMS; FERROELECTRIC PROPERTIES; MEMS; PB(ZR,TI)O-3; CRYSTALLIZATION; COMPOSITES; PB; SI AB This work attempts to optimize past research results on lead zirconate titanate (PZT) using the fabrication processes at the U. S. Army Research Laboratory so as to achieve a high degree of {001} texture and improved piezoelectric properties. A comparative study was performed between Ti/Pt and TiO2/Pt bottom electrodes. The results indicate that the use of a highly oriented {100} rutile phase TiO2 led to highly textured {111} Pt which in turn improved both the PTO and PZT orientations. PZT (52/48) and (45/55) thin films with and without PTO seed layers were deposited and examined via x-ray diffraction (XRD) methods as a function of annealing temperature. The seed layer provides significant improvement in the {100} orientation generally, and in the {001} subset of planes specifically, while suppressing the {111} orientation of the PZT. Improvements in the Lotgering factor (f) were observed from an existing Ti/Pt/PZT process (f = 0.66) to samples using the PTO seed layer deposited onto the improved Pt electrodes, TiO2/Pt/PTO/PZT (f = 0.96). C1 [Sanchez, Luz M.; Potrepka, Daniel M.; Polcawich, Ronald G.] US Army Res Lab, RF MEMS & Mm Scale Robot, Adelphi, MD 20783 USA. [Sanchez, Luz M.; Takeuchi, Ichiro] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Fox, Glen R.] Fox Mat Consulting LLC, Colorado Springs, CO 80908 USA. [Wang, Ke; Bendersky, Leonid A.] NIST, Div Met, Gaithersburg, MD 20886 USA. RP Sanchez, LM (reprint author), US Army Res Lab, RF MEMS & Mm Scale Robot, Adelphi, MD 20783 USA. EM Luz.Sanchez1@us.army.mil OI Potrepka, Daniel/0000-0002-0528-1038 NR 36 TC 15 Z9 15 U1 4 U2 26 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD JUL PY 2013 VL 28 IS 14 BP 1920 EP 1931 DI 10.1557/jmr.2013.172 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA 186DB UT WOS:000322021100006 ER PT J AU Liu, PH Yates, NL Shen, XY Bonsignori, M Moody, MA Liao, HX Fong, YY Alam, SM Overman, RG Denny, T Ferrari, G Ochsenbauer, C Kappes, JC Polonis, VR Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Rerks-Ngarm, S Montefiori, DC Gilbert, P Michael, NL Kim, JH Haynes, BF Tomaras, GD AF Liu, Pinghuang Yates, Nicole L. Shen, Xiaoying Bonsignori, Mattia Moody, M. Anthony Liao, Hua-Xin Fong, Youyi Alam, S. Munir Overman, R. Glenn Denny, Thomas Ferrari, Guido Ochsenbauer, Christina Kappes, John C. Polonis, Victoria R. Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Rerks-Ngarm, Supachai Montefiori, David C. Gilbert, Peter Michael, Nelson L. Kim, Jerome H. Haynes, Barton F. Tomaras, Georgia D. TI Infectious Virion Capture by HIV-1 gp120-Specific IgG from RV144 Vaccinees SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING-ANTIBODY-RESPONSE; B-CELL RESPONSES; NONNEUTRALIZING ANTIBODIES; T-CELLS; MONOCLONAL-ANTIBODY; MOLECULAR CLONES; INFLUENZA-VIRUS; EFFICACY TRIAL; REPLICATION AB The detailed examination of the antibody repertoire from RV144 provides a unique template for understanding potentially protective antibody functions. Some potential immune correlates of protection were untested in the correlates analyses due to inherent assay limitations, as well as the need to keep the correlates analysis focused on a limited number of endpoints to achieve statistical power. In an RV144 pilot study, we determined that RV144 vaccination elicited antibodies that could bind infectious virions (including the vaccine strains HIV-1 CM244 and HIV-1 MN and an HIV-1 strain expressing transmitted/founder Env, B.WITO.c). Among vaccinees with the highest IgG binding antibody profile, the majority (78%) captured the infectious vaccine strain virus (CM244), while a smaller proportion of vaccinees (26%) captured HIV-1 transmitted/founder Env virus. We demonstrated that vaccine-elicited HIV-1 gp120 antibodies of multiple specificities (V3, V2, conformational C1, and gp120 conformational) mediated capture of infectious virions. Although capture of infectious HIV-1 correlated with other humoral immune responses, the extent of variation between these humoral responses and virion capture indicates that virion capture antibodies occupy unique immunological space. C1 [Liu, Pinghuang; Yates, Nicole L.; Shen, Xiaoying; Bonsignori, Mattia; Moody, M. Anthony; Liao, Hua-Xin; Alam, S. Munir; Overman, R. Glenn; Denny, Thomas; Montefiori, David C.; Haynes, Barton F.; Tomaras, Georgia D.] Duke Univ, Duke Human Vaccine Inst, Durham, NC 27706 USA. [Liu, Pinghuang; Ferrari, Guido; Montefiori, David C.; Tomaras, Georgia D.] Duke Univ, Dept Surg, Durham, NC USA. [Liu, Pinghuang; Yates, Nicole L.; Shen, Xiaoying; Bonsignori, Mattia; Liao, Hua-Xin; Alam, S. Munir; Overman, R. Glenn; Denny, Thomas; Haynes, Barton F.] Duke Univ, Dept Med, Durham, NC USA. [Haynes, Barton F.; Tomaras, Georgia D.] Duke Univ, Dept Immunol, Durham, NC USA. [Tomaras, Georgia D.] Duke Univ, Dept Mol Genet & Microbiol, Durham, NC USA. [Moody, M. Anthony] Duke Univ, Dept Pediat, Durham, NC 27706 USA. [Fong, Youyi; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Div, SCHARP, Seattle, WA 98104 USA. [Ochsenbauer, Christina; Kappes, John C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Ochsenbauer, Christina; Kappes, John C.] UAB CFAR, Birmingham, AL USA. [Polonis, Victoria R.] Walter Reed Army Med Ctr, US Mil HIV Res Program, Rockville, MD USA. [Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Kaewkungwal, Jaranit] BIOPHICS, Ctr Excellence Biomed & Publ Hlth Informat, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, Sorachai; Michael, Nelson L.; Kim, Jerome H.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. RP Tomaras, GD (reprint author), Duke Univ, Duke Human Vaccine Inst, Durham, NC 27706 USA. EM gdt@duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016; OI Moody, Tony/0000-0002-3890-5855; Denny, Thomas/0000-0002-7364-8276 FU Bill and Melinda Gates Foundation [1032144, 1033098]; National Institutes of Health (NIH/NIAID/DAIDS); Center for HIV/AIDS Vaccine Immunology [U01 AI067854]; HIV-1 Vaccine Trials Network [5U01 AI46725-05]; Duke University Center for AIDS Research (CFAR) [P30 AI 64518]; UAB CFAR [P30 AI 27767]; U.S. Army Medical Research and Material Command through Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [Y1-AI-2642-12, W81XWH-07-2-0067]; National Institutes of Allergy and Infectious Diseases (NIAID) through Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [Y1-AI-2642-12, W81XWH-07-2-0067]; U.S. Army Medical Research and Material Command through U.S. Department of Defense (DOD) [Y1-AI-2642-12, W81XWH-07-2-0067]; National Institutes of Allergy and Infectious Diseases (NIAID) through U.S. Department of Defense (DOD) [Y1-AI-2642-12, W81XWH-07-2-0067] FX This study was supported by the Bill and Melinda Gates Foundation (grant 1032144 (CAVD-VIMC), 1033098), the National Institutes of Health (NIH/NIAID/DAIDS), the Center for HIV/AIDS Vaccine Immunology (grant U01 AI067854), the HIV-1 Vaccine Trials Network (5U01 AI46725-05), and the Duke University Center for AIDS Research (CFAR; grant P30 AI 64518) and the UAB CFAR (grant P30 AI 27767). In addition, funding was provided by Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material Command and the National Institutes of Allergy and Infectious Diseases (NIAID) through a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript. NR 57 TC 35 Z9 35 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 2013 VL 87 IS 14 BP 7828 EP 7836 DI 10.1128/JVI.02737-12 PG 9 WC Virology SC Virology GA 172PX UT WOS:000321017700005 PM 23658446 ER PT J AU Berkowitz, JF White, JR AF Berkowitz, Jacob F. White, John R. TI Linking Wetland Functional Rapid Assessment Models with Quantitative Hydrological and Biogeochemical Measurements across a Restoration Chronosequence SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID ORGANIC NITROGEN MINERALIZATION; SOUTHEASTERN BLACKWATER RIVERS; NUTRIENT DYNAMICS; EVERGLADES SOILS; PHOSPHORUS; HGM; DENITRIFICATION; SEQUESTRATION; TURNOVER; SEDIMENT AB The need for practical, repeatable, and technically sound ecosystem assessment methods remains essential to natural resource management. Rapid assessment methodologies determining ecosystem condition and function continue expansion, especially within wetlands. Few studies determine the accuracy of rapid assessment approaches by applying quantitative parameters, especially with respect to biogeochemical functions. Functional measurements require extensive sampling and analytical expertise, beyond financial and time constraints of most restoration projects. Further, measuring biogeochemical ecosystem functions requires the coupling of abundance measures (e.g., soil nutrient concentrations) with processing or transport mechanisms (e.g., microbial activity, flood frequency). This work assessed nutrient cycling, organic C export, and water quality improvement functions applied to >300 km(2) of restored bottomland hardwood forests, Mississippi River Valley. Assessment parameters (e.g., sapling shrub density, organic soil horizon thickness) and biogeochemical measures (e.g., microbial biomass C, potentially mineralizable N) were determined at 45 reforested areas and 21 control locations representing an 80-yr restoration chronosequence. Significantly higher rapid assessment outcomes were associated with increased ecosystem functionality (P = 0.001-0.029). These findings suggest that rapid assessment tools serve as reliable proxies for measurements of nutrient and biogeochemical cycling; validating the procedure examined. Assessment scores were also associated with increased restoration stand age (p(s) < 0.001) supporting further development of similar rapid assessments using ecosystem classification, qualitative data collection, and scaling based on reference data. The wide variety of rapid assessments in use underscores the need for validation with biogeochemical and hydrological measurements. C1 [Berkowitz, Jacob F.] US Army Corps Engineers, Wetlands & Coastal Ecol Branch, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Berkowitz, Jacob F.; White, John R.] Louisiana State Univ, Oceanog & Coastal Sci Dep, Wetland & Aquat Biogeochem Lab, Baton Rouge, LA 70803 USA. RP Berkowitz, JF (reprint author), US Army Corps Engineers, Wetlands & Coastal Ecol Branch, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jacob.F.Berkowitz@usace.army.mil RI White, John/A-7940-2008 OI White, John/0000-0002-9967-013X FU U.S. Army Corps of Engineers Vicksburg District FX Thanks to U.S. Army Corps of Engineers Vicksburg District for funding support, Darryl Evans and John Newton for data collection assistance, and Chris Noble and Sally Yost for providing comments on the manuscript. NR 73 TC 5 Z9 5 U1 1 U2 51 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 0361-5995 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD JUL-AUG PY 2013 VL 77 IS 4 BP 1442 EP 1451 DI 10.2136/sssaj2013.01.0044 PG 10 WC Soil Science SC Agriculture GA 186YZ UT WOS:000322083200033 ER PT J AU Weiner, MW Friedl, KE Pacifico, A Chapman, JC Jaffee, MS Little, DM Manley, GT McKee, A Petersen, RC Pitman, RK Yaffe, K Zetterberg, H Obana, R Bain, LJ Carrillo, MC AF Weiner, Michael W. Friedl, Karl E. Pacifico, Anthony Chapman, Julie C. Jaffee, Michael S. Little, Deborah M. Manley, Geoffrey T. McKee, Ann Petersen, Ronald C. Pitman, Roger K. Yaffe, Kristine Zetterberg, Henrik Obana, Robert Bain, Lisa J. Carrillo, Maria C. TI Military risk factors for Alzheimer's disease SO ALZHEIMERS & DEMENTIA LA English DT Article DE Alzheimer's disease; Risk factors; Military medicine; Traumatic brain injury; Posttraumatie stress disorder; Tau; Beta-amyloid; Apolipoprotein E e4; Biomarkers; Alzheimer's Disease Neuroimaging Initiative; Vietnam; Veterans; Chronic traumatic encephalopathy; Blast injury ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; POSTCONCUSSIVE SYMPTOMS; COGNITIVE RESERVE; HEAD-INJURY; BLAST; ENCEPHALOPATHY; HEALTH; CARE; AFGHANISTAN AB Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran. (C) 2013 The Alzheimer's Association. All rights reserved. C1 [Weiner, Michael W.; Yaffe, Kristine] San Francisco Vet Adm Med Ctr, San Francisco, CA USA. [Weiner, Michael W.; Manley, Geoffrey T.; Yaffe, Kristine] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Friedl, Karl E.; Pacifico, Anthony] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Chapman, Julie C.] Vet Affairs Med Ctr, War Related Illness & Injury Study Ctr, Washington, DC 20422 USA. [Chapman, Julie C.] Georgetown Univ, Sch Med, Washington, DC USA. [Jaffee, Michael S.] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA. [Little, Deborah M.] Texas A&M Hlth Sci Coll Med, College Stn, TX USA. [McKee, Ann] Boston Univ, Sch Med, New England Vet Healthcare Syst, Boston, MA 02118 USA. [McKee, Ann] Boston Univ, Sch Med, Brain Banks, Boston, MA 02118 USA. [McKee, Ann] Ctr Study Traumat Encephalopathy, Boston, MA USA. [Petersen, Ronald C.] Mayo Clin, Rochester, MN USA. [Pitman, Roger K.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Zetterberg, Henrik] Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden. [Obana, Robert] Vet Hlth Res Inst, Northern Calif Inst Res & Educ, San Francisco, CA USA. [Carrillo, Maria C.] Alzheimers Assoc, Chicago, IL USA. [Zetterberg, Henrik] UCL Inst Neurol, London WC1N 3BG, England. RP Carrillo, MC (reprint author), Alzheimers Assoc, Chicago, IL USA. EM Maria.Carrillo@alz.org RI Saykin, Andrew/A-1318-2007; Schmidt, Mark/I-5052-2016; Jack, Clifford/F-2508-2010; OI Saykin, Andrew/0000-0002-1376-8532; Schmidt, Mark/0000-0003-3417-8977; Jack, Clifford/0000-0001-7916-622X; Friedl, Karl/0000-0002-3134-8427 NR 48 TC 36 Z9 36 U1 6 U2 27 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUL PY 2013 VL 9 IS 4 BP 445 EP 451 DI 10.1016/j.jalz.2013.03.005 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 182GF UT WOS:000321729000013 PM 23809365 ER PT J AU Gauer, RL AF Gauer, Robert L. TI Early Recognition and Management of Sepsis in Adults: The First Six Hours SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID GOAL-DIRECTED THERAPY; OF-THE-LITERATURE; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; EMERGENCY-DEPARTMENT; TRANSFUSION REQUIREMENTS; ANTIMICROBIAL THERAPY; FLUID RESPONSIVENESS; METAANALYSIS AB Sepsis is a complication of severe infection characterized by a systemic inflammatory response. Mortality rates from sepsis range between 25% to 30% for severe sepsis and 40% to 70% for septic shock. The clinical presentation of sepsis is highly variable depending on the etiology. The most common sites of infection are the respiratory, genitourinary, and gastrointestinal systems, as well as the skin and soft tissue. Fever is often the first manifestation of sepsis, with pneumonia being the most common presentation leading to sepsis. Early goal-directed therapy completed within the first six hours of sepsis recognition significantly decreases in-hospital mortality. Initial management includes respiratory stabilization followed by aggressive fluid resuscitation. Vasopressor therapy is indicated when fluid resuscitation fails to restore adequate mean arterial pressure and organ perfusion. Early antibiotic therapy can improve clinical outcomes, and should be given within one hour of suspected sepsis. Blood product therapy may be required in some cases to correct coagulopathy and anemia, and to improve the central venous oxygen saturation. Insulin therapy may be required to maintain serum glucose levels less than 180 mg per dL. Initiation of low-dose corticosteroids may further improve survival in patients with septic shock that does not respond to vasopressor therapy. Timely initiation of evidence-based protocols should improve sepsis outcomes. (Am Fam Physician. 2013;88(1):44-53. Copyright 2013 American Academy of Family Physicians.) C1 Womack Army Med Ctr, Ft Bragg, NC 28310 USA. RP Gauer, RL (reprint author), Womack Army Med Ctr, Bldg 4-2817,Reilly Rd, Ft Bragg, NC 28310 USA. EM robertgauer@yahoo.com NR 45 TC 9 Z9 10 U1 0 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 1 PY 2013 VL 88 IS 1 BP 44 EP 53 PG 10 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 178TE UT WOS:000321469500006 PM 23939605 ER PT J AU Bandara, S Baril, N Maloney, P Billman, C Nallon, E Shih, T Pellegrino, J Tidrow, M AF Bandara, Sumith Baril, Neil Maloney, Patrick Billman, Curtis Nallon, Eric Shih, Tiffany Pellegrino, Joseph Tidrow, Meimei TI Heterojunction-based GaSb/InAs strained-layer superlattice long wavelength infrared detectors SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT International Conference on Quantum Structure Infrared Photodetector (QSIP) CY JUN 18-22, 2012 CL Inst Etudes Sci Cargese, FRANCE SP III V Lab, JPL, Acreo, ONERA, Aselsan, Pulse Instruments, FLIR, Qmagiq, Intelli EPI, Sofradir, Wafer Technol Ltd, Thales, Collectivite Territoriale Corse HO Inst Etudes Sci Cargese DE Long-wave; Infrared detectors; Strained layer superlattice; Heterojunction ID PERFORMANCE AB Design parameters for the heterojunction-based strained layer superlattice (SLS) long-wave infrared (LWIR) detector are investigated so that it operates at a lower bias voltage with lower dark current and higher photo response. At typical operating temperatures (T similar to 77 K), the dark current of GaSb/InAs SLS LWIR detectors is dominated by the Shockley-Read-Hall (SRH) generation-recombination (g-r) process in the space-charge (depletion) region. In order to suppress this dark current, a wide bandgap region next to the absorber layer has been included in recent SLS designs. A series of heterojunction-based LWIR SLS detectors with various doping and barrier profiles have been designed and characterized. The significance of the doping profile and thickness of the wide-bandgap layer in optimization of the heterojunction-based SLS detector performance are exhibited from the modeling and experimental results of these devices. Published by Elsevier B.V. C1 [Bandara, Sumith; Baril, Neil; Maloney, Patrick; Billman, Curtis; Nallon, Eric; Shih, Tiffany; Pellegrino, Joseph; Tidrow, Meimei] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Bandara, S (reprint author), US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 11 TC 1 Z9 1 U1 3 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD JUL PY 2013 VL 59 BP 18 EP 21 DI 10.1016/j.infrared.2012.12.003 PG 4 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA 172BL UT WOS:000320974800004 ER PT J AU Feala, JD AbdulHameed, MDM Yu, CG Dutta, B Yu, XP Schmid, K Dave, J Tortella, F Reifman, J AF Feala, Jacob D. AbdulHameed, Mohamed Diwan M. Yu, Chenggang Dutta, Bhaskar Yu, Xueping Schmid, Kara Dave, Jitendra Tortella, Frank Reifman, Jaques TI Systems Biology Approaches for Discovering Biomarkers for Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Review DE biomarker; pathway analysis; protein-protein interaction; systems biology; traumatic brain injury ID PROTEIN-PROTEIN INTERACTIONS; SPECTROMETRY-BASED PROTEOMICS; FIBRILLARY ACIDIC PROTEIN; SET ENRICHMENT ANALYSIS; C-TERMINAL HYDROLASE; RAT CEREBRAL-CORTEX; GENE-EXPRESSION; INTERACTION NETWORKS; MASS-SPECTROMETRY; BREAST-CANCER AB The rate of traumatic brain injury (TBI) in service members with wartime injuries has risen rapidly in recent years, and complex, variable links have emerged between TBI and long-term neurological disorders. The multifactorial nature of TBI secondary cellular response has confounded attempts to find cellular biomarkers for its diagnosis and prognosis or for guiding therapy for brain injury. One possibility is to apply emerging systems biology strategies to holistically probe and analyze the complex interweaving molecular pathways and networks that mediate the secondary cellular response through computational models that integrate these diverse data sets. Here, we review available systems biology strategies, databases, and tools. In addition, we describe opportunities for applying this methodology to existing TBI data sets to identify new biomarker candidates and gain insights about the underlying molecular mechanisms of TBI response. As an exemplar, we apply network and pathway analysis to a manually compiled list of 32 protein biomarker candidates from the literature, recover known TBI-related mechanisms, and generate hypothetical new biomarker candidates. C1 [Feala, Jacob D.; AbdulHameed, Mohamed Diwan M.; Yu, Chenggang; Dutta, Bhaskar; Yu, Xueping; Reifman, Jaques] USA, Med Res & Mat Command, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Schmid, Kara; Dave, Jitendra; Tortella, Frank] Walter Reed Army Inst Res, Dept Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM Jaques.Reifman.civ@mail.mil RI AbdulHameed, Mohamed Diwan M/O-3088-2015 OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084 FU U.S. Department of Defense, Defense Medical Research and Development Program; U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland [D61_I_10_J6_126] FX The authors were supported, in part, by the U.S. Department of Defense, Defense Medical Research and Development Program managed by the U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland (project no.: D61_I_10_J6_126). NR 126 TC 15 Z9 15 U1 0 U2 17 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2013 VL 30 IS 13 BP 1101 EP 1116 DI 10.1089/neu.2012.2631 PG 16 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 174WB UT WOS:000321186400001 PM 23510232 ER PT J AU Zoltewicz, JS Mondello, S Yang, BX Newsom, KJ Kobeissy, F Yao, CP Lu, XCM Dave, JR Shear, DA Schmid, K Rivera, V Cram, T Seaney, J Zhang, ZQ Wang, KKW Hayes, RL Tortella, FC AF Zoltewicz, J. Susie Mondello, Stefania Yang, Boxuan Newsom, Kimberly J. Kobeissy, Firas Yao, Changping Lu, Xi-Chun May Dave, Jitendra R. Shear, Deborah A. Schmid, Kara Rivera, Virginia Cram, Terri Seaney, Jixiang Zhang, Zhiqun Wang, Kevin K. W. Hayes, Ronald L. Tortella, Frank C. TI Biomarkers Track Damage after Graded Injury Severity in a Rat Model of Penetrating Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; GFAP; penetrating brain injury; SBDP150; UCH-L1 ID ALPHA-II-SPECTRIN; C-TERMINAL HYDROLASE; FIBRILLARY ACIDIC PROTEIN; TRAUMATIC BRAIN; BREAKDOWN PRODUCTS; CEREBROSPINAL-FLUID; SERUM-LEVELS; CELL-DEATH; CALPAIN; EXPOSURE AB The goal of this project was to determine whether biochemical markers of brain damage can be used to diagnose and assess the severity of injury in a rat model of penetrating ballistic-like brain injury (PBBI). To determine the relationship between injury magnitude and biomarker levels, rats underwent three discrete PBBI severity levels defined by the magnitude of the ballistic component of the injury, calibrated to equal 5%, 10%, or 12.5% of total rat brain volume. Cortex, cerebrospinal fluid (CSF), and blood were collected at multiple time points. Levels of three biomarkers (alpha II-spectrin breakdown product [SBDP150], glial fibrillary acidic protein [GFAP], and ubiquitin C-terminal hydrolase-L1 [UCH-L1]), were measured using quantitative immunoblotting and/or enzyme-linked immunosorbent assays. In injured cortex, SBDP150 and GFAP levels were increased significantly over controls. Cortical SBDP150 was elevated at 1 day but not 7 days, and GFAP at 7 days but not 1 day. At their respective time points, mean levels of SBDP150 and GFAP biomarkers in the cortex rose stepwise as injury magnitude increased. In the CSF, increasing severity of PBBI was associated with increasing concentrations of both neuronal and glial biomarkers acutely at 1 day after injury, but no trends were observed at 7 days. In plasma, SBDP150 was elevated at 5 min after 10% PBBI and at 6 h after 12.5% PBBI. UCH-L1 levels in plasma were elevated acutely at 5 min post-injury reflecting injury severity and rapidly decreased within 2 h. Overall, our results support the conclusion that biomarkers are effective indicators of brain damage after PBBI and may also aid in the assessment of injury magnitude. C1 [Zoltewicz, J. Susie; Mondello, Stefania; Yang, Boxuan; Newsom, Kimberly J.; Kobeissy, Firas; Rivera, Virginia; Cram, Terri; Seaney, Jixiang; Hayes, Ronald L.] Banyan Biomarkers Inc, Alachua, FL 32615 USA. [Yao, Changping; Lu, Xi-Chun May; Dave, Jitendra R.; Shear, Deborah A.; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Kobeissy, Firas; Zhang, Zhiqun; Wang, Kevin K. W.] Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA. RP Zoltewicz, JS (reprint author), Banyan Biomarkers Inc, 13400 Progress Blvd, Alachua, FL 32615 USA. EM szoltewicz@banyanbio.com RI kobeissy, firas/E-7042-2017; OI kobeissy, firas/0000-0002-5008-6944; Wang, Kevin/0000-0002-9343-6473; Mondello, Stefania/0000-0002-8587-3614 FU Department of Defense [W81XWH-07-2-0075] FX This study was supported by Department of Defense W81XWH-07-2-0075 to Ronald Hayes. Many thanks to Nancy Denslow for her editing of the manuscript and helpful advice. NR 33 TC 14 Z9 14 U1 0 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2013 VL 30 IS 13 BP 1161 EP 1169 DI 10.1089/neu.2012.2762 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 174WB UT WOS:000321186400007 PM 23409698 ER PT J AU Smith, TJ Dotson, LE Young, AJ White, A Hadden, L Bathalon, GP Funderburk, L Marriott, BP AF Smith, Tracey J. Dotson, Laura E. Young, Andrew J. White, Alan Hadden, Louise Bathalon, Gaston P. Funderburk, LesLee Marriott, Bernadette P. TI Eating Patterns and Leisure-Time Exercise among Active Duty Military Personnel: Comparison to the Healthy People Objectives SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Dietary Guidelines; Healthy People; Military personnel; Physical activity ID NATIONALLY REPRESENTATIVE SAMPLE; DIETARY ENERGY DENSITY; BODY-MASS INDEX; UNITED-STATES; BREAKFAST CONSUMPTION; PHYSICAL-ACTIVITY; WEIGHT-GAIN; US ADULTS; FOOD-CONSUMPTION; LIFE-STYLE AB Objective To assess whether active duty military personnel meet Healthy People 2010 objectives for physical activity and fruit, vegetable, and whole-grain intake; the relationship of select demographic characteristics, lifestyle factors (eg, smoking), and eating patterns (eg, frequency and location of meals) on achieving diet and exercise-related Healthy People 2010 objectives; and the relationship of eating patterns to self-reported weight gain. Methods Secondary data from 15,747 participants in the 2005 Department of Defense Health Related Behaviors Survey was analyzed. Results More than 57% of respondents met the Healthy People 2010 guidelines for moderate or vigorous leisure exercise but only 3% reported eating fruit (once), vegetables (3 times), and whole grains (3 times) daily. Individuals who reported gaining weight during the previous year were more likely to skip breakfast and eat at, or from, a restaurant >= 2 times per week compared with those who did not gain weight (P<0.001). Regression analysis indicated that women were more likely to eat fruits (odds ratio [OR] 1.25) and vegetables (OR 1.20) and less likely than men to eat whole grains (OR 0.76) or engage in moderate or vigorous exercise (OR 0.71). Military personnel who skipped breakfast >= 2 times per week (OR 0.45) or ate at a restaurant/takeout food (OR 0.54) >= 2 :times per week were significantly less likely to meet Healthy People 2010 guidelines for food intake (defined as achieving a daily intake of one or more fruits, three or more vegetables, and three or more servings of whole grains) and exercise (OR 0.88 and 0.82, respectively). Conclusions Although the majority of military personnel met guidelines for physical activity, their intake of fruits, vegetables, and whole grains was suboptimal. Skipping breakfast and eating at, or from, restaurants were risk factors for poor nutrient intake and associated with weight gain. These data suggest that skipping breakfast and eating out deter achieving Healthy People 2010 objectives and provide targets for military programs to promote achieving these objectives. C1 [Smith, Tracey J.; Young, Andrew J.; Funderburk, LesLee] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Dotson, Laura E.; Marriott, Bernadette P.] Samueli Inst, Alexandria, VA USA. [White, Alan; Marriott, Bernadette P.] ABT Associates Inc, Durham, NC USA. [Hadden, Louise] ABT Associates Inc, Cambridge, MA USA. [Bathalon, Gaston P.] USA, Environm Med Res Inst, Natick, MA USA. [Funderburk, LesLee] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Marriott, Bernadette P.] Med Univ S Carolina, Charleston, SC USA. [Marriott, Bernadette P.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA. RP Smith, TJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Tracey.Smith10.civ@mail.mil FU US Army [W911QY-09-P-0082]; Abt Associates Inc FX The analysis reported in this article was supported in full by US Army contract No. W911QY-09-P-0082 with Abt Associates Inc, and a subcontract from Abt Associates Inc to the Samueli Institute. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the Army, Department of Defense, or Tricare Management Activity. Any citations of commercial organizations and trade names in this article do not constitute an official Department Of the Army endorsement of approval of the products or services of these organizations. NR 48 TC 8 Z9 8 U1 2 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD JUL PY 2013 VL 113 IS 7 BP 907 EP 919 DI 10.1016/j.jand.2013.03.002 PG 13 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 183FI UT WOS:000321799300006 PM 23647834 ER PT J AU Crombie, AP Funderburk, L Smith, TJ McGraw, SM Walker, LA Champagne, CM Allen, HR Margolis, LM McClung, HL Young, AJ AF Crombie, Aaron P. Funderburk, LesLee Smith, Tracey J. McGraw, Susan M. Walker, Leila A. Champagne, Catherine M. Allen, H. Raymond Margolis, Lee M. McClung, Holly L. Young, Andrew J. TI Effects of Modified Foodservice Practices in Military Dining Facilities on Ad Libitum Nutritional Intake of US Army Soldiers SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Cafeteria; Dining facility; Military; Dietary intake; Overweight ID FOOD CHOICES; INCREASE FRUIT; CAFETERIA; INTERVENTION; SELECTIONS; BEHAVIOR; OBESITY; ADULTS; COST AB Background Modifying foodservice practices in military dining facilities could influence ad libitum nutritional intake patterns of soldiers. Objective We aimed to determine how changes in foodservice operations consistent with 2005 Dietary Guidelines for Americans affected soldiers' ad libitum nutritional intake in military dining facilities (DFACs). Design Ten DFACs participated, and the intervention was implemented in five DFACs in an independently sampled, partial crossover design. Nutrient intake of diners was assessed during a test meal using digital photography, and customer satisfaction with foodservice was assessed via surveys at baseline (n=602), and again at 6 months (n=519) and 12 months (n=458) after the intervention was implemented. Participants Volunteers were US Army active duty soldiers recruited from among diners at 10 DFACs on Fort Bragg, NC. Main outcome measures Primary outcomes were intakes of energy and total fat, and percent energy from fat and saturated fat. Differences between diners' intakes in control and intervention DFACs were assessed using independent samples t tests. Results At 6 months after implementing the intervention, diners at intervention DFACs had significantly lower lunchtime intakes of energy (945 +/- 338 kcal vs 1,061 +/- 380 kcal), total fat (38 +/- 19 g vs 47 +/- 25 g), percent energy from fat (35%+/- 10% vs 39%+/- 11%) and saturated fat (4.7%+/- 1.7% vs 5.6%+/- 2.3%), discretionary fat (30 +/- 18 g vs 39 +/- 24 g), and refined grains (2.3 +/- 1.7 oz equivalents vs 2.8 +/- 2.4 oz equivalents) compared with diners at control DFACs. Further, diners at intervention DFACs rated customer satisfaction higher than diners at control DFACs. Conclusions These findings suggest that modest changes in military DFAC serving practices to promote healthy eating and food selection can facilitate positive changes in soldiers' nutritional intake. C1 [Crombie, Aaron P.; Funderburk, LesLee; Smith, Tracey J.; McGraw, Susan M.; Walker, Leila A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Margolis, Lee M.; McClung, Holly L.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Champagne, Catherine M.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Allen, H. Raymond] Pennington Biomed Res Ctr, Comp Serv, Baton Rouge, LA USA. RP Crombie, AP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM aaron.crombie@us.army.mil OI , Lee/0000-0002-0652-1304 FU US Army Medical Research and Materiel Command FX This work was supported by funding from the US Army Medical Research and Materiel Command to Task Area A: Nutritional Sustainment of Military Operational Health. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 32 TC 5 Z9 5 U1 2 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD JUL PY 2013 VL 113 IS 7 BP 920 EP 927 DI 10.1016/j.jand.2013.01.005 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 183FI UT WOS:000321799300007 PM 23419999 ER PT J AU Walsh, GF Dal Negro, L AF Walsh, Gary F. Dal Negro, Luca TI Enhanced Second Harmonic Generation by Photonic-Plasmonic Fano-Type Coupling in Nanoplasmonic Arrays SO NANO LETTERS LA English DT Article DE Plasmonics; second harmonic generation; Fano resonance; surface enhanced Raman scattering; nonlinearities ID NANOPARTICLE DIMERS; PLANAR ARRAYS; RESONANCE; LIGHT; SPECTROSCOPY; METAMATERIALS; NANOANTENNAS; NANOCAVITIES; EXCITATION; SCATTERING AB In this communication, we systematically investigate the effects of Fano-type coupling between long-range photonic resonances and localized surface plasmons on the second harmonic generation from periodic arrays of Au nanoparticles arranged in monomer and dimer geometries. Specifically, by scanning the wavelength of an ultrafast tunable pump laser over a large range, we measure the second harmonic excitation spectra of these arrays and demonstrate their tunability with particle size and separation. Moreover, through a comparison with linear optical transmission spectra, which feature asymmetric Fano-type lineshapes, we demonstrate that the second harmonic generation is enhanced when coupled photonicplasmonic resonances of the arrays are excited at the fundamental pump wavelength, thus boosting the intensity of the electromagnetic near-fields. Our experimental results, which are supported by numerical simulations of linear optical transmission and near-field enhancement spectra based on the Finite Difference Time Domain method, demonstrate a direct correlation between the onset of Fano-type coupling and the enhancement of second harmonic generation in arrays of Au nanoparticles. Our findings enable the engineering of the nonlinear optical response of Fano-type coupled nanoparticle arrays that are relevant to a number of device applications in nonlinear nano-optics and plasmonics, such as on-chip frequency generators, modulators, switchers, and sensors. C1 [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA. [Dal Negro, Luca] Boston Univ, Div Mat Sci & Engn, Brookline, MA 02446 USA. RP Dal Negro, L (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM dalnegro@bu.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center; SMART Scholarship Program; AFOSR [FA9550-13-1-0011]; NSF Career Award [ECCS-0846651] FX This work was supported by the U.S. Army Natick Soldier Research, Development, and Engineering Center, and the SMART Scholarship Program. This work was also partially supported by the AFOSR program under Award FA9550-13-1-0011 and by the NSF Career Award No. ECCS-0846651. This document has been approved for public release. NSRDEC PAO #:U13-099. NR 49 TC 59 Z9 59 U1 8 U2 143 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD JUL PY 2013 VL 13 IS 7 BP 3111 EP 3117 DI 10.1021/nl401037n PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 184IW UT WOS:000321884300018 PM 23800228 ER PT J AU Fromzel, V Ter-Gabrielyan, N Dubinskii, M AF Fromzel, V. Ter-Gabrielyan, N. Dubinskii, M. TI Acousto-optically Q-switched, resonantly pumped, Er:YVO4 laser SO OPTICS EXPRESS LA English DT Article AB We report on the performance of an acousto-optically Q-switched Er:YVO4 laser resonantly pumped in the (4)I1(5/2) -> I-4(13/2) transition. The laser output was pi-polarized at 1603 nm. It operated with a 1-40 kHz pulse repetition rate (PRR) and delivered up to 1.15 W of average output power. A slope efficiency of 45% with respect to the absorbed pump power was demonstrated at the pulse repetition rates of 10 kHz and above. The best Q-switched operation with 470 mu J, 50 ns long pulses was achieved at the PRR of 1-2 kHz and pumping with a fiber-coupled laser diode. This Q-switched pulse energy is the highest reported for Er:YVO4 single crystal laser. (C) 2013 Optical Society of America C1 [Fromzel, V.; Ter-Gabrielyan, N.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Fromzel, V (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 9 TC 3 Z9 3 U1 0 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 1 PY 2013 VL 21 IS 13 BP 15253 EP 15258 DI 10.1364/OE.21.015253 PG 6 WC Optics SC Optics GA 176FF UT WOS:000321288400033 PM 23842311 ER PT J AU Mascari, TM Stout, RW Clark, JW Gordon, SW Bast, JD Foil, LD AF Mascari, T. M. Stout, R. W. Clark, J. W. Gordon, S. W. Bast, J. D. Foil, L. D. TI Insecticide-treated rodent baits for sand fly control SO PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY LA English DT Article DE Systemic insecticide; Feed-through; Sand fly; Vector control ID FLIES DIPTERA PSYCHODIDAE; CUTANEOUS LEISHMANIASIS; ORAL TREATMENT; FEED-THROUGH; KENYA; EFFICACY AB Rodent baits containing systemic insecticides are potential tools to interrupt the cycle of transmission of Leishmania parasites by killing sand flies that take bloodmeals from rodents as adults. Bio-indicators that can be used in conjunction with rodent-targeted sand fly control methods also have been developed to demonstrate that the insecticide treatments are reaching the targeted life stages of sand flies and to quantify the effect of the insecticide treatments on sand fly populations. This article presents new results from a field study on the use of rodent bait containing a systemic insecticide in Kenya. The objective of this field study was to incorporate the fluorescent dye rhodamine B into rodent baits to determine the level of blood feeding by the sand fly Phlebotomus duboscqi on targeted rodents, and to demonstrate the effect of rodent bait containing the systemic insecticide ivermectin on bloodfeeding adult females of P. duboscqi. Over 50% of the bloodfed females of P. duboscqi collected at sites that were treated with rodent baits containing rhodamine B alone were positive for the presence of rhodamine B while no bloodfed females of P. duboscqi collected at the sites treated with rodent baits containing rhodamine B plus ivermectin were positive for the presence of rhodamine B. The results of this field trial constitute proof of concept for the targeted control of an epidemiologically significant portion of the population of the sand fly vector of Leishmania major, and demonstrate the potential for the interruption of the transmission of L. major using applications of systemic insecticide-treated rodent baits. (C) 2013 Published by Elsevier Inc. C1 [Mascari, T. M.; Foil, L. D.] Louisiana State Univ Agr Ctr, Dept Entomol, Baton Rouge, LA 70803 USA. [Stout, R. W.] Louisiana State Univ Sch Vet Med, Div Lab Anim Med, Baton Rouge, LA USA. [Clark, J. W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gordon, S. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bast, J. D.] US Army Med Res Unit Kenya, Unit 8900, Dpo, AE USA. RP Foil, LD (reprint author), Louisiana State Univ Agr Ctr, Agr Expt Stn, Dept Entomol, Baton Rouge, LA 70803 USA. EM lfoil@agcenter.lsu.edu FU Deployed War-Fighter Protection (DWFP) Research Program; U.S. Department of Defense through the Armed Forces Pest Management Board (AFPMB) FX This work was supported by a grant from the Deployed War-Fighter Protection (DWFP) Research Program, funded by the U.S. Department of Defense through the Armed Forces Pest Management Board (AFPMB). This article was published with approval of the Director of Louisiana Agricultural Experiment Station. NR 11 TC 2 Z9 2 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0048-3575 J9 PESTIC BIOCHEM PHYS JI Pest. Biochem. Physiol. PD JUL PY 2013 VL 106 IS 3 SI SI BP 113 EP 117 DI 10.1016/j.pestbp.2013.04.006 PG 5 WC Biochemistry & Molecular Biology; Entomology; Physiology SC Biochemistry & Molecular Biology; Entomology; Physiology GA 183HM UT WOS:000321805100007 ER PT J AU Montgomery, RK Reddoch, KM Evani, SJ Cap, AP Ramasubramanian, AK AF Montgomery, Robbie K. Reddoch, Kristin M. Evani, Shankar J. Cap, Andrew P. Ramasubramanian, Anand K. TI Enhanced shear-induced platelet aggregation due to low-temperature storage SO TRANSFUSION LA English DT Article ID VON-WILLEBRAND-FACTOR; SELF-ASSOCIATION; GLYCOPROTEIN IB; FLOW-CYTOMETRY; GPIB-ALPHA; ACTIVATION; CLEARANCE; VIABILITY; BLOOD; REFRIGERATION AB BackgroundRefrigeration of platelets (PLTs) offers an attractive alternative to the currently practiced storage at room temperature since it may mitigate problems associated with bacterial contamination and extend storage lifetime. Refrigeration causes a number of biophysical and biochemical changes in PLTs and decreases PLT circulation time in vivo. However, the effect of refrigeration on PLT hemostatic functions under physiologic and pathophysiologic shear conditions has not been adequately characterized. Study Design and MethodsWashed PLTs prepared from either fresh PLT-rich plasma (PRP) or PRP stored at 4 degrees C for 2 days was mixed with exogenous von Willebrand factor (VWF) and fibrinogen and sheared in a cone-and-plate viscometer. PLT aggregation, activation, and VWF binding after shear and glycoprotein (GP) Ib receptor expression and ristocetin-induced PLT agglutination were measured. ResultsPLTs stored at 4 degrees C for 2 days aggregated significantly more than fresh PLTs particularly at high shear rates (10,000/sec), and this increase was independent of PLT concentration or suspension viscosity. Further, refrigerated PLTs showed a greater increase in GP Ib-dependent PLT activation under shear and also bound more VWF than fresh PLTs. However, the GP Ib expression levels as measured by three different antibodies were significantly lower in refrigerated PLTs than in fresh PLTs, and refrigeration resulted in a modest decrease in ristocetin-induced PLT agglutination. ConclusionThe combined results demonstrate that refrigeration increases PLT aggregation under high shear, but not static, conditions and also increases shear-induced VWF binding and PLT activation. Clinically, enhanced shear-induced PLT aggregation due to low temperature storage may be a beneficial strategy to prevent severe bleeding in trauma. C1 [Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, San Antonio, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA. RP Cap, AP (reprint author), US Army Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA. EM andre.p.cap@us.army.mil; anand.ramasubramanian@utsa.edu FU San Antonio Life Sciences Institute FX This work was partially supported by a grant from the San Antonio Life Sciences Institute. NR 36 TC 12 Z9 12 U1 0 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD JUL PY 2013 VL 53 IS 7 BP 1520 EP 1530 DI 10.1111/j.1537-2995.2012.03917.x PG 11 WC Hematology SC Hematology GA 180RI UT WOS:000321612400022 PM 23043289 ER PT J AU Palacios, G Forrester, NL Savji, N da Rosa, APAT Guzman, H DeToy, K Popov, VL Walker, PJ Lipkin, WI Vasilakis, N Tesh, RB AF Palacios, Gustavo Forrester, Naomi L. Savji, Nazir da Rosa, Amelia P. A. Travassos Guzman, Hilda DeToy, Kelly Popov, Vsevolod L. Walker, Peter J. Lipkin, W. Ian Vasilakis, Nikos Tesh, Robert B. TI Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae SO VIROLOGY JOURNAL LA English DT Article DE Farmington virus (FARV); Family Rhabdoviridae; Next generation sequencing; Phylogeny ID VESICULAR STOMATITIS-VIRUS; PHYLOGENETIC-RELATIONSHIPS; MATRIX PROTEIN; RNA-POLYMERASE; GLYCOPROTEIN-G; DOMAINS; ARCHITECTURE; SMART; MOTIF; GENE AB Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings: Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae. C1 [Palacios, Gustavo] US Army Med Res Inst Infect Dis, Ctr Genom Sci, Frederick, MD 10032 USA. [Forrester, Naomi L.; da Rosa, Amelia P. A. Travassos; Guzman, Hilda; Popov, Vsevolod L.; Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Forrester, Naomi L.; da Rosa, Amelia P. A. Travassos; Guzman, Hilda; Popov, Vsevolod L.; Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. [Forrester, Naomi L.; Vasilakis, Nikos] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA. [Forrester, Naomi L.; Popov, Vsevolod L.; Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA. [Savji, Nazir; DeToy, Kelly; Lipkin, W. Ian] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY 10032 USA. [Walker, Peter J.] CSIRO Anim Food & Hlth Sci, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia. RP Tesh, RB (reprint author), Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. EM rtesh@utmb.edu RI Walker, Peter/H-6059-2013; Palacios, Gustavo/I-7773-2015 OI Walker, Peter/0000-0003-1851-642X; Palacios, Gustavo/0000-0001-5062-1938 FU Department of Pathology; Institute for Human Infections and Immunity, University of Texas Medical Branch; NIH [HHSN272201000040I/HHSN27200004/D04]; Institute for Human Infections and Immunity Pathogen Genomics Program [AI157158]; Defense Threat Reduction Agency FX We thank Farooq Nasar for his critical review of this manuscript. This work is supported in part by the Department of Pathology start up funds, a grant from the Institute for Human Infections and Immunity, University of Texas Medical Branch (NV), NIH contract HHSN272201000040I/HHSN27200004/D04 (RBT), the Institute for Human Infections and Immunity Pathogen Genomics Program (NLF), AI157158 (Northeast Biodefense Center-Lipkin) and the Defense Threat Reduction Agency. NR 32 TC 7 Z9 7 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUL 1 PY 2013 VL 10 AR 219 DI 10.1186/1743-422X-10-219 PG 10 WC Virology SC Virology GA 188LH UT WOS:000322194000001 PM 23816310 ER PT J AU Mirecki, JE Bennett, MW Lopez-Balaez, MC AF Mirecki, June E. Bennett, Michael W. Lopez-Balaez, Marie C. TI Arsenic Control During Aquifer Storage Recovery Cycle Tests in the Floridan Aquifer SO GROUND WATER LA English DT Article ID BACTERIAL SULFATE REDUCTION; FRAMBOIDAL PYRITE; CARBONATE AQUIFER; REDOX CONDITIONS; RECLAIMED WATER; IRON; MOBILITY; MINERALS; SULFIDE AB Implementation of aquifer storage recovery (ASR) for water resource management in Florida is impeded by arsenic mobilization. Arsenic, released by pyrite oxidation during the recharge phase, sometimes results in groundwater concentrations that exceed the 10 mu g/L criterion defined in the Safe Drinking Water Act. ASR was proposed as a major storage component for the Comprehensive Everglades Restoration Plan (CERP), in which excess surface water is stored during the wet season, and then distributed during the dry season for ecosystem restoration. To evaluate ASR system performance for CERP goals, three cycle tests were conducted, with extensive water-quality monitoring in the Upper Floridan Aquifer (UFA) at the Kissimmee River ASR (KRASR) pilot system. During each cycle test, redox evolution from sub-oxic to sulfate-reducing conditions occurs in the UFA storage zone, as indicated by decreasing Fe2+/H2S mass ratios. Arsenic, released by pyrite oxidation during recharge, is sequestered during storage and recovery by co-precipitation with iron sulfide. Mineral saturation indices indicate that amorphous iron oxide (a sorption surface for arsenic) is stable only during oxic and sub-oxic conditions of the recharge phase, but iron sulfide (which co-precipitates arsenic) is stable during the sulfate-reducing conditions of the storage and recovery phases. Resultant arsenic concentrations in recovered water are below the 10 mu g/L regulatory criterion during cycle tests 2 and 3. The arsenic sequestration process is appropriate for other ASR systems that recharge treated surface water into a sulfate-reducing aquifer. C1 [Mirecki, June E.; Lopez-Balaez, Marie C.] US Army Corps Engineers, Jacksonville, FL 32207 USA. [Bennett, Michael W.] AECOM Inc, W Palm Beach, FL 33409 USA. RP Mirecki, JE (reprint author), US Army Corps Engineers, 701 San Marco Blvd, Jacksonville, FL 32207 USA. EM june.e.mirecki@usace.army.mil NR 47 TC 5 Z9 5 U1 1 U2 45 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-467X J9 GROUND WATER JI Ground Water PD JUL PY 2013 VL 51 IS 4 BP 539 EP 549 DI 10.1111/j.1745-6584.2012.01001.x PG 11 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA 175UJ UT WOS:000321258800008 PM 23106789 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI "A Change of Both Men and Measures": British Reassessment of Military Strategy after Saratoga, 1777-1778 SO JOURNAL OF MILITARY HISTORY LA English DT Article AB After the Battle of Saratoga (October 1777) in the American War of Independence, British leaders conducted a comprehensive reassessment of their military strategy but examined the new strategy's ways and means without considering the ends or objectives of the war. Using extensive primary sources, this article examines the reassessment process and concludes that the effort was fatally flawed because King George III and his ministers failed to reevaluate the war's objectives, given the changed strategic environment after Saratoga. The resulting British military strategy suffered from an imbalance between ends, ways, and means. Thus, British leaders incurred significant risk in executing their new strategy. C1 US Army War Coll, Carlisle, PA USA. RP Weddle, KJ (reprint author), US Army War Coll, Carlisle, PA USA. NR 60 TC 0 Z9 0 U1 1 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2013 VL 77 IS 3 BP 837 EP 865 PG 29 WC History SC History GA 174NM UT WOS:000321162700002 ER PT J AU Mears, DS AF Mears, Dwight S. TI The Catch-22 Effect: The Lasting Stigma of Wartime Cowardice in the US Army Air Forces SO JOURNAL OF MILITARY HISTORY LA English DT Article AB During World War II, U.S. airmen circulated pernicious rumors about the motives of the hundreds of aircrews who landed in neutral countries. Although investigated and disproven by the leadership of the U.S. Army Air Forces (USAAF), the rumors persisted in popular memory and ultimately stigmatized the veterans who endured neutral captivity. This essay examines the motives of some airmen who landed in Switzerland, and argues that the stigma associated with neutral captivity resulted in denials of benefits and military decorations to deserving veterans. C1 US Mil Acad, West Point, NY USA. RP Mears, DS (reprint author), US Mil Acad, West Point, NY USA. NR 62 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2013 VL 77 IS 3 BP 1025 EP 1054 PG 30 WC History SC History GA 174NM UT WOS:000321162700008 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI Kill Anything That Moves: The Real American War in Vietnam SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Daddis, Gregory A.] US Mil Acad, West Point, NY 10996 USA. RP Daddis, GA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2013 VL 77 IS 3 BP 1174 EP 1176 PG 3 WC History SC History GA 174NM UT WOS:000321162700073 ER PT J AU Leung, LY Wei, G Shear, DA Tortella, FC AF Leung, Lai Yee Wei, Guo Shear, Deborah A. Tortella, Frank C. TI The Acute Effects of Hemorrhagic Shock on Cerebral Blood Flow, Brain Tissue Oxygen Tension, and Spreading Depolarization following Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain tissue oxygen tension; cerebral blood flow; cortical spreading depolarization; hemorrhagic shock; traumatic brain injury ID SEVERE HEAD-INJURY; SUBARACHNOID HEMORRHAGE; INTRACRANIAL-PRESSURE; PERFUSION-PRESSURE; SECONDARY INSULTS; NITRIC-OXIDE; DEPRESSION; MODEL; HYPOTENSION; DAMAGE AB Traumatic brain injury (TBI) often occurs in conjunction with additional trauma, resulting in secondary complications, such as hypotension as a result of blood loss. This study investigated the combined effects of penetrating ballistic-like brain injury (PBBI) and hemorrhagic shock (HS) on physiological parameters, including acute changes in regional cerebral blood flow (rCBF), brain tissue oxygen tension (PbtO2), and cortical spreading depolarizations (CSDs). All recordings were initiated before injury (PBBI/HS/both) and maintained for 2.5 h. Results showed that PBBI alone and combined PBBI and HS produced a sustained impairment of ipsilateral rCBF that decreased by 70% from baseline (p < 0.05). Significant and sustained reductions in PbtO2 (50% baseline; p < 0.05) were also observed in the injured hemisphere of the animals subjected to both PBBI and HS (PBBI + HS). In contrast, PBBI alone produced smaller, more transient reductions in PbtO2 levels. The lower limit of cerebral autoregulation was significantly higher in the PBBI + HS group (p < 0.05, compared to HS alone). Critically, combined injury resulted in twice the number of spontaneous CSDs as in PBBI alone (p < 0.05). It also lowered the propagation speed of CSD and the threshold of CSD occurrence [induced CSD at higher mean arterial pressure (MAP)]. However, rCBF and PbtO2 were not responsive to the depolarizations. Our data suggest that PBBI together with HS causes persistent impairment of CBF and brain tissue oxygen tension, increasing the probability of CSDs that likely contribute to secondary neuropathology and compromise neurological recovery. C1 [Leung, Lai Yee; Wei, Guo; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Leung, LY (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave,2W12, Silver Spring, MD 20910 USA. EM laiyee.leung@us.army.mil RI Leung, Lai Yee/H-8204-2013 FU Combat Casualty Care Research Program; U.S. Army Medical Research and Materiel Command; National Research Council Research Associateship Program (National Academy of Sciences, Washington, DC) FX The views of the authors do not purport or reflect the position of the Department of the Army or the Department of Defense (para 4-3, AR 360-5). This research is funded by the Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command. The primary author is sponsored by the National Research Council Research Associateship Program (National Academy of Sciences, Washington, DC). The authors thank Dr. Jed A. Hartings (University of Cincinnati, Cincinnati, OH) for his valuable advice on cortical spreading depolarization and SPC Shawn McLoughlin and Ms. Xiaofang Yang for their technical support. NR 44 TC 6 Z9 6 U1 0 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2013 VL 30 IS 14 BP 1288 EP 1298 DI 10.1089/neu.2012.2715 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 183MV UT WOS:000321821100009 PM 23461630 ER PT J AU Bennett, T Vanderhoff, M Pratt, W Miller, M AF Bennett, Thomas Vanderhoff, Mark Pratt, William Miller, Matthew TI Correlation of cardiovascular parameters with troponin levels following isoproteronol administration to dogs SO JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS LA English DT Meeting Abstract C1 [Bennett, Thomas; Vanderhoff, Mark; Miller, Matthew] Noesys Data, College Stn, TX USA. [Pratt, William] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1056-8719 J9 J PHARMACOL TOX MET JI J. Pharmacol. Toxicol. Methods PD JUL-AUG PY 2013 VL 68 IS 1 MA 117 BP E33 EP E34 DI 10.1016/j.vascn.2013.01.123 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 178IW UT WOS:000321442300111 ER PT J AU Chandler, MQ Bammann, DJ Horstemeyer, MF AF Chandler, Mei Qiang Bammann, Douglas J. Horstemeyer, M. F. TI A continuum model for hydrogen-assisted void nucleation in ductile materials SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID NANOVOID NUCLEATION; GRAIN-BOUNDARIES; DAMAGE EVOLUTION; STRESS STATE; CRACK-TIP; METALS; FRACTURE; STEEL; ALLOYS; NICKEL AB The bulk effects of hydrogen on the kinematics, thermodynamics, and kinetics of plasticity and damage evolution were derived based on the constitutive equations of the Bammann continuum plasticity and Horstemeyer damage mechanics framework. From nanoscale atomistic simulation results and existing experimental observations, the Horstemeyer-Gokhale void/crack nucleation rate was modified to account for hydrogen effects. The continuum damage framework was implemented into a user material code and applied in finite element simulations. The finite element results showed close comparisons with the experimental data from Kwon and Asaro who charged smooth and notched spheroidized 1518 steel specimens with hydrogen. C1 [Chandler, Mei Qiang] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Bammann, Douglas J.; Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. RP Chandler, MQ (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Mei.Q.Chandler@usace.army.mil OI Horstemeyer, Mark/0000-0003-4230-0063 FU Center for Advanced Vehicular Systems (CAVS) at Mississippi State University FX The authors thank the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University for funding this work. The permission to publish this work is granted by the Director of the Geotechnical and Structures Laboratory, US Army Engineer Research and Development Center. NR 54 TC 0 Z9 0 U1 0 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD JUL PY 2013 VL 21 IS 5 AR 055028 DI 10.1088/0965-0393/21/5/055028 PG 18 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 176FJ UT WOS:000321288800028 ER PT J AU Chandler, MQ Peters, JF Pelessone, D AF Chandler, Mei Qiang Peters, John F. Pelessone, Daniele TI Discrete element modeling of calcium-silicate-hydrate SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID C-S-H; CEMENT-BASED MATERIALS; PORTLAND-CEMENT; COHESION; CONCRETE; PASTE; PARTICLES; FORCES AB The discrete element method (DEM) was used to model calcium-silicate-hydrate (C-S-H) at the nanoscale. The C-S-H nanoparticles were modeled as spherical particles with diameters of approximately 5 nm. Interparticle forces included traditional mechanical contact forces, van der Waals forces and ionic correlation forces due to negatively charged C-S-H nanoparticles and ion species in the nanopores. Previous work by the authors demonstrated the DEM method was feasible in studying the properties of the C-S-H nanostructures. In this work, the simulations were performed to look into the effects of nanoparticle packing, nanoparticle morphology, interparticle forces and nanoparticle properties on the deformation mechanisms and mechanical properties of the C-S-H matrix. This work will provide insights into possible ways to improve the properties of the C-S-H matrix. C1 [Chandler, Mei Qiang; Peters, John F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Pelessone, Daniele] ES3, San Diego, CA 92101 USA. RP Chandler, MQ (reprint author), US Army Engineer Res & Dev Ctr, 3909 Hall Ferry Rd, Vicksburg, MS 39180 USA. FU military basic research program FX The authors acknowledge the support for this work provided by military basic research program. Permission to publish was granted by Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 27 TC 2 Z9 2 U1 1 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD JUL PY 2013 VL 21 IS 5 AR 055010 DI 10.1088/0965-0393/21/5/055010 PG 23 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 176FJ UT WOS:000321288800010 ER PT J AU Ranasinghe, S Cutler, S Davis, I Lu, R Soghoian, DZ Qi, Y Sidney, J Kranias, G Flanders, MD Lindqvist, M Kuhl, B Alter, G Deeks, SG Walker, BD Gao, XJ Sette, A Carrington, M Streeck, H AF Ranasinghe, Srinika Cutler, Sam Davis, Isaiah Lu, Richard Soghoian, Damien Z. Qi, Ying Sidney, John Kranias, Gregory Flanders, Michael D. Lindqvist, Madelene Kuhl, Bjorn Alter, Galit Deeks, Steven G. Walker, Bruce D. Gao, Xiaojiang Sette, Alessandro Carrington, Mary Streeck, Hendrik TI Association of HLA-DRB1-restricted CD4(+) T cell responses with HIV immune control SO NATURE MEDICINE LA English DT Article ID INFECTION; PROGRESSION; MOLECULES; PROTEINS; EPITOPES AB The contribution of HLA class II-restricted CD4(+) T cell responses to HIV immune control is poorly defined. Here, we delineated previously uncharacterized peptide-DRB1 restrictions in functional assays and analyzed the host genetic effects of HLA-DRB1 alleles on HIV viremia in a large cohort of HIV controllers and progressors. We found distinct stratifications in the effect of HLA-DRB1 alleles on HIV viremia, with HLA-DRB1*15:02 significantly associated with low viremia and HLA-DRB1*03:01 significantly associated with high viremia. Notably, a subgroup of HLA-DRB1 variants linked with low viremia showed the ability to promiscuously present a larger breadth of peptides with lower functional avidity when compared to HLA-DRB1 variants linked with high viremia. Our data provide systematic evidence that HLA-DRB1 variant expression has a considerable impact on the control of HIV replication, an effect that seems to be mediated primarily by the protein specificity of CD4(+) T cell responses to HIV Gag and Nef. C1 [Ranasinghe, Srinika; Cutler, Sam; Davis, Isaiah; Lu, Richard; Soghoian, Damien Z.; Kranias, Gregory; Flanders, Michael D.; Lindqvist, Madelene; Kuhl, Bjorn; Alter, Galit; Walker, Bruce D.; Carrington, Mary; Streeck, Hendrik] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA. [Ranasinghe, Srinika; Cutler, Sam; Davis, Isaiah; Lu, Richard; Soghoian, Damien Z.; Kranias, Gregory; Flanders, Michael D.; Lindqvist, Madelene; Kuhl, Bjorn; Alter, Galit; Walker, Bruce D.; Carrington, Mary; Streeck, Hendrik] Harvard Univ, Cambridge, MA 02138 USA. [Qi, Ying; Gao, Xiaojiang; Carrington, Mary] NCI, Canc & Inflammat Program, Expt Immunol Lab, Sci Applicat Int Corp Frederick, Frederick, MD 21701 USA. [Sidney, John; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [Deeks, Steven G.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Henry M Jackson Fdn, Silver Spring, MD USA. EM hstreeck@hivresearch.org FU US National Institutes of Health (NIH) [R01 AI091450, R01 AI094602]; Henry M. Jackson Foundation; US Department of Defense [W81XWH-07-2-0067]; NIH/National Institute of Allergy and Infectious Diseases (NIAID) [5P30AI060354-09]; Center for HIV/AIDS Immunology and Immunogen Discovery (CHAVI-ID); MGH Executive Committee on Research Fund for Medical Discovery; US Intramural Research Program of the US National Institutes of Health, National Cancer Institute (NCI), Center for Cancer Research [HHSN261200800001E]; Centers for AIDS Research at UCSF [PO AI27763]; CFAR Network of Integrated Systems [R24 AI067039]; UCSF Clinical and Translational Science Institute [UL1 RR024131]; NIAID [RO1 AI087145, K24 AI069994]; Mark and Lisa Schwartz Foundation; Bill & Melinda Gates Foundation; AIDS Healthcare Foundation; CFAR, an NIH [P30 AI060354]; NIH; NIAID; NCI; National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Fogarty International Center; Organization for Autism Research FX We thank all individuals whose participation enabled this study. This study was funded by the US National Institutes of Health (NIH) (R01 AI091450 and R01 AI094602). H. S. is funded through R01 AI091450 and R01 AI094602 and the Henry M. Jackson Foundation by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense (W81XWH-07-2-0067). S. R. is supported by a Harvard CFAR Scholar Award (NIH/National Institute of Allergy and Infectious Diseases (NIAID) 5P30AI060354-09), Center for HIV/AIDS Immunology and Immunogen Discovery (CHAVI-ID) and MGH Executive Committee on Research Fund for Medical Discovery. This project has also been funded in part with federal funds from the US Intramural Research Program of the US National Institutes of Health, National Cancer Institute (NCI), Center for Cancer Research, under contract HHSN261200800001E. The UCSF SCOPE cohort was supported by the Centers for AIDS Research at UCSF (PO AI27763), CFAR Network of Integrated Systems (R24 AI067039), the UCSF Clinical and Translational Science Institute (UL1 RR024131), and NIAID (RO1 AI087145 and K24 AI069994). The MGH cohort was supported by the Mark and Lisa Schwartz Foundation and the Collaboration of AIDS Vaccine Discovery of the Bill & Melinda Gates Foundation. This research has been supported in part by the International HIV Controllers Study, funded by the Bill & Melinda Gates Foundation, the AIDS Healthcare Foundation and CFAR, an NIH-funded program (P30 AI060354) that is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of Mental Health, National Institute on Aging, Fogarty International Center and Organization for Autism Research. We thank M. Ghebremichael for statistical assistance and Y. Yuki for HLA genotyping. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. NR 21 TC 33 Z9 33 U1 1 U2 6 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD JUL PY 2013 VL 19 IS 7 BP 930 EP + DI 10.1038/nm.3229 PG 5 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 179YB UT WOS:000321557700038 PM 23793098 ER PT J AU Hsu, A Wang, H Shin, YC Mailly, B Zhang, X Yu, LL Shi, YM Lee, YH Dubey, M Kim, KK Kong, J Palacios, T AF Hsu, Allen Wang, Han Shin, Yong Cheol Mailly, Benjamin Zhang, Xu Yu, Lili Shi, Yumeng Lee, Yi Hsien Dubey, Madan Kim, Ki Kang Kong, Jing Palacios, Tomas TI Large-Area 2-D Electronics: Materials, Technology, and Devices SO PROCEEDINGS OF THE IEEE LA English DT Article DE Boron nitride (BN); circuits; graphene; molybdenum disulfide (MoS2); transistors ID HEXAGONAL BORON-NITRIDE; CHEMICAL-VAPOR-DEPOSITION; SINGLE-LAYER MOS2; FIELD-EFFECT TRANSISTORS; EPITAXIAL-GRAPHENE; CONTACT RESISTANCE; MONOLAYER GRAPHENE; ROOM-TEMPERATURE; GRAPHITE OXIDE; BAND-GAP AB Recent experiments since the discovery of monolayer graphite or graphene have led to an exciting revival in the interest in the electronic applications for graphene, as well as other 2-D materials such as hexagonal boron nitride (hBN) and molybdenum disulfide (MoS2). These layered materials serve as an exciting new platform for flexible and transparent electronics where surfaces can be enriched with new functionality. This paper aims to provide an overview behind these new class of materials ranging upon important issues for electronic integration including synthesis all the way to current state-of-the-art circuits and devices made from these materials. C1 [Hsu, Allen; Wang, Han; Shin, Yong Cheol; Zhang, Xu; Yu, Lili; Kong, Jing; Palacios, Tomas] MIT, Cambridge, MA 02139 USA. [Mailly, Benjamin] MIT, Dept Mat Sci & Engn DMSE, Cambridge, MA 02139 USA. [Shi, Yumeng] Singapore Univ Technol & Design, Singapore 138682, Singapore. [Lee, Yi Hsien] MIT, Elect Engn & Comp Sci Dept EECS, Cambridge, MA 02139 USA. [Dubey, Madan] Army Res Labs ARL, Adelphi, MD 20783 USA. [Kim, Ki Kang] Dongguk Univ, Seoul 100715, South Korea. RP Hsu, A (reprint author), MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM allenhsu@mit.edu RI Wang, Han/E-9063-2011; Shi, Yumeng/A-7349-2012 OI Wang, Han/0000-0002-1543-2020; Shi, Yumeng/0000-0002-9623-3778 FU Army Research Laboratory; MIT-ARMY Institute for Soldier Nanotechnologies; Young Investigator Program; GATE MURI program of the U.S. Office of Naval Research FX This work was supported by the Army Research Laboratory, the MIT-ARMY Institute for Soldier Nanotechnologies, the Young Investigator Program, and the GATE MURI program of the U.S. Office of Naval Research. NR 151 TC 25 Z9 25 U1 6 U2 173 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD JUL PY 2013 VL 101 IS 7 SI SI BP 1638 EP 1652 DI 10.1109/JPROC.2013.2251311 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 167WW UT WOS:000320667200010 ER PT J AU Zheng, BL Ashford, D Zhou, YZ Mathaudhu, SN Delplanque, JP Lavernia, EJ AF Zheng, Baolong Ashford, Dustin Zhou, Yizhang Mathaudhu, Suveen N. Delplanque, Jean-Pierre Lavernia, Enrique J. TI Influence of mechanically milled powder and high pressure on spark plasma sintering of Mg-Cu-Gd metallic glasses SO ACTA MATERIALIA LA English DT Article DE Metallic glass; Structural relaxation; Sintering; Simulation; Interface ID STRUCTURAL RELAXATION; FORMING ABILITY; COLD COMPACTION; IRON POWDERS; PART II; ALLOYS; DEFORMATION; STRENGTH; BEHAVIOR; CONSOLIDATION AB In this study a gas atomized Mg65Cu25Gd10 amorphous powder was mechanically milled and consolidated by spark plasma sintering (SPS) at a high pressure (500 MPa) at different temperatures (443, 433, and 423 K) to provide an insight into the consolidation and mechanical behavior of Mg-based metallic glasses. Microstructural evolution in the vicinity of the interfaces of SPSed Mg-Cu-Gd BMG powders was characterized using scanning and transmission electron microscopy, and the associated amorphous phase transformation and thermal stability were analyzed using X-ray diffraction and differential scanning calorimetry. The results show that interfacial bonding between amorphous particles was enhanced by the disruption of surface oxides as well as by structural relaxation of the milled powder and the presence of high pressure during SPS. A finite element method with COMSOL software was also applied to investigate and explain the powder packing density, localized heating, and temperature distribution during SPS. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Zheng, Baolong; Ashford, Dustin; Zhou, Yizhang; Delplanque, Jean-Pierre; Lavernia, Enrique J.] Univ Calif Davis, Davis, CA 95616 USA. [Mathaudhu, Suveen N.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zheng, BL (reprint author), Univ Calif Davis, Davis, CA 95616 USA. EM bzheng@ucdavis.edu RI Lavernia, Enrique/I-6472-2013; Mathaudhu, Suveen/B-4192-2009; Delplanque, Jean-Pierre/I-8690-2016; OI Lavernia, Enrique/0000-0003-2124-8964; Delplanque, Jean-Pierre/0000-0003-1774-1641 FU US Army Research Office [ARO W911NF-10-1-0512]; Materials Design Institute; LANL/UC Davis Education Research Collaboration, Los Alamos National Laboratory (LANS) [75782-001-09]; UC Laboratory Fees Research Program Contingency Funds FX The authors acknowledge financial support provided by the US Army Research Office (ARO W911NF-10-1-0512), and the Materials Design Institute, funded by the LANL/UC Davis Education Research Collaboration, Los Alamos National Laboratory (LANS Subcontract No. 75782-001-09), and the UC Laboratory Fees Research Program Contingency Funds. Thanks are due to Prof. Chi Y.A. Tsao, National Cheng Kung University, Tainan, Taiwan, for providing the atomized Mg65Cu25Gd10 powder. NR 59 TC 15 Z9 15 U1 6 U2 74 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD JUL PY 2013 VL 61 IS 12 BP 4414 EP 4428 DI 10.1016/j.actamat.2013.04.011 PG 15 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 173NL UT WOS:000321086100011 ER PT J AU Muramatsu, RS Silva, N Ahmed, I AF Muramatsu, Russ S. Silva, Nicole Ahmed, Iqbal TI Suspected Dronabinol Withdrawal in an Elderly Cannabis-Naive Medically Ill Patient SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Letter C1 [Muramatsu, Russ S.] Uniformed Serv Univ Hlth Sci, Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI USA. Uniformed Serv Univ Hlth Sci, Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI USA. RP Muramatsu, RS (reprint author), Uniformed Serv Univ Hlth Sci, Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI USA. NR 4 TC 0 Z9 0 U1 0 U2 3 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD JUL PY 2013 VL 170 IS 7 BP 804 EP 805 DI 10.1176/appi.ajp.2013.13010059 PG 2 WC Psychiatry SC Psychiatry GA 172RX UT WOS:000321023700020 PM 23820836 ER PT J AU Kuhn, JH Radoshitzky, SR Bavari, S Jahrling, PB AF Kuhn, Jens H. Radoshitzky, Sheli R. Bavari, Sina Jahrling, Peter B. TI The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses SO ARCHIVES OF VIROLOGY LA English DT Article ID SPECIES NAMES; TAXONOMY AB The International Committee on Taxonomy of Viruses (ICTV) is responsible for the classification of viruses into taxa. Importantly, the ICTV is currently not responsible for the nomenclature of viruses or their subclassification into strains, lineages, or genotypes. ICTV rules for classification of viruses and nomenclature of taxa are laid out in a code, the International Code of Virus Classification and Nomenclature (ICVCN). The most recent version of the Code makes it difficult for the unfamiliar reader to distinguish between viruses and taxa, thereby often giving the impression that certain Rules apply to viruses. Here, Code text changes are proposed to address this problem. C1 [Kuhn, Jens H.; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, Frederick, MD 21702 USA. [Radoshitzky, Sheli R.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU NIAID [HHSN272200200016I] FX The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, the US Department of Defense, the US Department of the Army, or of the institutions and companies affiliated with the authors. JHK performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200200016I. NR 12 TC 0 Z9 0 U1 2 U2 10 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PD JUL PY 2013 VL 158 IS 7 BP 1621 EP 1629 DI 10.1007/s00705-012-1582-6 PG 9 WC Virology SC Virology GA 173GN UT WOS:000321066600025 PM 23417351 ER PT J AU Stec, J Fomovska, A Afanador, GA Muench, SP Zhou, Y Lai, BS El Bissati, K Hickman, MR Lee, PJ Leed, SE Auschwitz, JM Sommervile, C Woods, S Roberts, CW Rice, D Prigge, ST McLeod, R Kozikowski, AP AF Stec, Jozef Fomovska, Alina Afanador, Gustavo A. Muench, Stephen P. Zhou, Ying Lai, Bo-Shiun El Bissati, Kamal Hickman, Mark R. Lee, Patty J. Leed, Susan E. Auschwitz, Jennifer M. Sommervile, Caroline Woods, Stuart Roberts, Craig W. Rice, David Prigge, Sean T. McLeod, Rima Kozikowski, Alan P. TI Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii SO CHEMMEDCHEM LA English DT Article DE enoyl reductase; inhibitors; medicinal chemistry; Toxoplasma gondii; triclosan ID FATTY-ACID BIOSYNTHESIS; DIARYL ETHER INHIBITORS; PLASMODIUM-FALCIPARUM; APICOMPLEXAN PARASITES; IN-VITRO; MYCOBACTERIUM-TUBERCULOSIS; BIOLOGICAL-ACTIVITY; ESCHERICHIA-COLI; DRUG TARGET; FABI AB Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was used to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma gondii (TgENR). Modifications to positions 5 and 4 of the well-known ENR inhibitor triclosan afforded a series of 29 new analogues. Among the resulting compounds, many showed high potency and improved physicochemical properties in comparison with the lead. The most potent compounds 16a and 16c have IC50 values of 250nM against Toxoplasma gondii tachyzoites without apparent toxicity to the host cells. Their IC50 values against recombinant TgENR were found to be 43 and 26nM, respectively. Additionally, 11 other analogues in this series had IC50 values ranging from 17 to 130nM in the enzyme-based assay. With respect to their excellent invitro activity as well as improved drug-like properties, the lead compounds 16a and 16c are deemed to be excellent starting points for the development of new medicines to effectively treat Toxoplasma gondii infections. C1 [Stec, Jozef; Kozikowski, Alan P.] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL 60612 USA. [Fomovska, Alina; Zhou, Ying; Lai, Bo-Shiun; El Bissati, Kamal; McLeod, Rima] Univ Chicago, Comm Genet, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Chicago, IL 60637 USA. [Fomovska, Alina; Zhou, Ying; Lai, Bo-Shiun; El Bissati, Kamal; McLeod, Rima] Univ Chicago, Comm Immunol, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Chicago, IL 60637 USA. [Fomovska, Alina; Zhou, Ying; Lai, Bo-Shiun; El Bissati, Kamal; McLeod, Rima] Univ Chicago, Comm Mol Med, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Chicago, IL 60637 USA. [Fomovska, Alina; Zhou, Ying; Lai, Bo-Shiun; El Bissati, Kamal; McLeod, Rima] Univ Chicago, The Coll, Chicago, IL 60637 USA. [Afanador, Gustavo A.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA. [Muench, Stephen P.] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England. [Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Dept Discovery, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Sommervile, Caroline; Woods, Stuart; Roberts, Craig W.; Rice, David] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland. [Rice, David] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England. [Stec, Jozef] Chicago State Univ, Coll Pharm, Chicago, IL 60628 USA. [Fomovska, Alina] Mt Sinai Sch Med, New York, NY 10029 USA. RP McLeod, R (reprint author), Univ Chicago, Comm Genet, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Chicago, IL 60637 USA. EM rmcleod@uchicago.edu; kozikowa@uic.edu OI Muench, Stephen/0000-0001-6869-4414; Roberts, Craig/0000-0002-0653-835X FU NIAID [U01 AI082180-01]; MRC [G1000567]; Rooney-Alden family; Taub family; Engel family; Pritzker family; Harris family; Mussilami family; Samuel family; Mann-Cornwell Family Foundation FX The authors are grateful for financial support provided by NIAID (U01 AI082180-01), the Rooney-Alden, Taub, Engel, Pritzker, Harris, Mussilami and Samuel families, and the Mann-Cornwell Family Foundation. Special thanks to Dr. W. Tuckmantel for useful discussions and comments on the manuscript. S.P.M. is supported by an MRC Career Development fellowship (G1000567). We thank C. Van Tubbergen for her assistance with preparation of the manuscript. NR 77 TC 10 Z9 10 U1 0 U2 27 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1860-7179 J9 CHEMMEDCHEM JI ChemMedChem PD JUL PY 2013 VL 8 IS 7 BP 1138 EP 1160 DI 10.1002/cmdc.201300050 PG 23 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 171LA UT WOS:000320928400010 PM 23776166 ER PT J AU Costanzo, ME McArdle, JJ Swett, B Nechaev, V Kemeny, S Xu, J Braun, AR AF Costanzo, Michelle E. McArdle, Joseph J. Swett, Bruce Nechaev, Vladimir Kemeny, Stefan Xu, Jiang Braun, Allen R. TI Spatial and temporal features of superordinate semantic processing studied with fMRI and EEG SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE semantic processing; modality independent; superordinate categorization; fMRI; ERP ID EVENT-RELATED POTENTIALS; INDEPENDENT COMPONENT ANALYSIS; PARIETAL CORTEX; HUMAN BRAIN; TIME-COURSE; OBJECT CATEGORIZATION; MULTIPLE SEMANTICS; FUNCTIONAL-ANATOMY; WORD REPETITION; ANGULAR GYRUS AB The relationships between the anatomical representation of semantic knowledge in the human brain and the timing of neurophysiological mechanisms involved in manipulating such information remain unclear. This is the case for superordinate semantic categorization-the extraction of general features shared by broad classes of exemplars (e.g., living vs. non-living semantic categories). We proposed that, because of the abstract nature of this information, input from diverse input modalities (visual or auditory, lexical or non-lexical) should converge and be processed in the same regions of the brain, at similar time scales during superordinate categorization-specifically in a network of heteromodal regions, and late in the course of the categorization process. In order to test this hypothesis, we utilized electroencephalography and event related potentials (EEG/ERP) with functional magnetic resonance imaging (fMRI) to characterize subjects' responses as they made superordinate categorical decisions (living vs. non-living) about objects presented as visual pictures or auditory words. Our results reveal that, consistent with our hypothesis, during the course of superordinate categorization, information provided by these diverse inputs appears to converge in both time and space: fMRI showed that heteromodal areas of the parietal and temporal cortices are active during categorization of both classes of stimuli. The ERP results suggest that superordinate categorization is reflected as a late positive component (LPC) with a parietal distribution and long latencies for both stimulus types. Within the areas and times in which modality independent responses were identified, some differences between living and non-living categories were observed, with a more widespread spatial extent and longer latency responses for categorization of non-living items. C1 [Costanzo, Michelle E.; McArdle, Joseph J.; Swett, Bruce; Nechaev, Vladimir; Kemeny, Stefan; Xu, Jiang; Braun, Allen R.] Natl Inst Deafness & Other Commun Disorders, Language Sect, NIH, Bethesda, MD 20892 USA. [Costanzo, Michelle E.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [McArdle, Joseph J.] Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, Aberdeen, MD USA. [Swett, Bruce] EOIR Technol Inc, Lorton, VA USA. [Xu, Jiang] PAREXEL Early Phase Clin, Centreville, VA USA. RP Braun, AR (reprint author), Natl Inst Deafness & Other Commun Disorders, Language Sect, NIH, Bldg 10,Room 5D-37, Bethesda, MD 20892 USA. EM brauna@nidcd.nih.gov RI chen, zhu/K-5923-2013 FU Intramural Program of NIDCD FX This work was supported by the Intramural Program of NIDCD. NR 82 TC 5 Z9 5 U1 1 U2 20 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD JUL 1 PY 2013 VL 7 AR 293 DI 10.3389/fnhum.2013.00293 PG 13 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 174XW UT WOS:000321192300001 PM 23847490 ER PT J AU Saling, KG White, KP AF Saling, Kristin Graham White, K. Preston, Jr. TI Integrating probabilistic design and rare-event simulation into the requirements engineering process for high-reliability systems SO INTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH LA English DT Article DE simulation; reliability; engineering; uncertainty modeling; risk analysis; performance evaluation ID MONTE-CARLO-SIMULATION; NASA SPACE-SHUTTLE; AVAILABILITY; RISK AB Early in a program, engineers must determine requirements for system reliability and availability. We suggest that existing techniques gathered from diverse fields can be incorporated within the framework of systems engineering methodology to accomplish this. Specifically, adopting probabilistic (Monte Carlo) design techniques allows the designer to incorporate uncertainty explicitly into the design process and to improve the designer's understanding of the root causes of failures and how often these might realistically occur. In high-reliability systems in which failure occurs infrequently, rare-event simulation techniques can reduce the computational burden of achieving this understanding. This paper provides an introductory survey of the literature on systems engineering, requirements engineering, Monte Carlo simulation, probabilistic design, and rare-event simulation with the aim of assessing the degree to which these have been integrated in systems design for reliability. This leads naturally to a proposed framework for the fusion of these techniques. C1 [Saling, Kristin Graham] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [White, K. Preston, Jr.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22902 USA. RP Saling, KG (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM kcg9g@virginia.edu; kpwhite@virginia.edu NR 68 TC 1 Z9 1 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0969-6016 EI 1475-3995 J9 INT T OPER RES JI Int. Trans. Oper. Res. PD JUL PY 2013 VL 20 IS 4 BP 515 EP 531 DI 10.1111/itor.12023 PG 17 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 161EN UT WOS:000320174800004 ER PT J AU Kaminski, RW Clarkson, K Kordis, AA Oaks, EV AF Kaminski, Robert W. Clarkson, Kristen Kordis, Alexis A. Oaks, Edwin V. TI Multiplexed immunoassay to assess Shigella-specific antibody responses SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE Shigella; Ipa; LPS; Antibodies; Multiplexed assay ID INVASION PLASMID ANTIGENS; MENINGITIDIS SEROGROUP-A; FLOW-CYTOMETRIC ASSAY; FLEXNERI 2A; IMMUNOGLOBULIN-A; RHESUS-MONKEYS; SIMULTANEOUS QUANTITATION; NEUTRALIZING EPITOPES; MONOCLONAL-ANTIBODIES; LUMINEX ASSAY AB Infection with Shigella spp. results in bacillary dysentery and a systemic and mucosa] antibody response. The immune response is directed at multiple antigens, including LPS and the invasin plasmid antigen (Ipa) proteins, and is capable of conferring short-term, serotype-specific protection. Both live-attenuated and several subunit vaccine approaches have focused on inducing a pronounced mucosal immune response directed to the same antigens recognized after natural infection. Traditionally, Shigella-specific antibody responses are measured using ELISA. Although ELISAs are robust immunological assays, limited sample volume and assay costs often precludes its use for immunological evaluation against multiple antigens. To overcome these shortcomings, a novel assay has been developed to simultaneously measure specific antibody levels to six Shigella antigens, including three serotype-specific LPS preparations and three conserved protein antigens in a Luminex (TM)-based system. Coupling methods were optimized to covalently link recombinant Ipa proteins (IpaB, IpaC, and IpaD) and purified LPS from Shigella sonnei, Shigella flexneri 2a, and Shigella dysenteriae 1 to unique bead sets. The antigen-coupled beads maintained stable reactivity with monoclonal antibodies (mAbs) for 6 weeks (protein) to 3 months (LPS). The specificity of the Luminex assay was similar to an ELISA, with the multiplexed assay providing a larger dynamic range. Comparable levels of antigen-specific reactivity were attained in monoplex or multiplex formats indicating limited interference. The correlations (R-2) between the ELISA and the multiplexed assay along with the repeatability and reproducibility of the assay were very high. Minor changes in species-specific conjugated secondary antibodies allowed the optimized multiplexed assays to be used to assess antigen-specific antibodies in serum or blood eluted from filter paper isolated from mice and guinea pigs highlighting applicability of the assay for seroepidemiology and pre-clinical/clinical vaccine studies. Published by Elsevier B.V. C1 [Kaminski, Robert W.; Clarkson, Kristen; Kordis, Alexis A.; Oaks, Edwin V.] Walter Reed Army Inst Res, Dept Subunit Enter Vaccines & Immunol, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Kaminski, RW (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Robert.W.Kaminski.civ@mail.mil FU Military Infectious Disease Research Program (MIDRP) FX Military Infectious Disease Research Program (MIDRP). The sponsor did not play a role in the study design, collection, analysis, or interpretation of data, in writing the report or in the decision to submit the article for publication. NR 45 TC 4 Z9 4 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUL PY 2013 VL 393 IS 1-2 BP 18 EP 29 DI 10.1016/j.jim.2013.04.002 PG 12 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 171EL UT WOS:000320907800003 PM 23583496 ER PT J AU Gubata, ME Urban, N Cowan, DN Niebuhr, DW AF Gubata, Marlene E. Urban, Nadia Cowan, David N. Niebuhr, David W. TI A prospective study of physical fitness, obesity, and the subsequent risk of mental disorders among healthy young adults in army training SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE Mental disorders; Obesity; Physical fitness; Screening ID HARVARD STEP TEST; COMORBIDITY SURVEY REPLICATION; DSM-IV DISORDERS; VITAMIN-D; PSYCHIATRIC-DISORDERS; CARE UTILIZATION; US MILITARY; PREACCESSION FITNESS; DEPRESSIVE SYMPTOMS; NEUROTROPHIC FACTOR AB Objective: Mental health disorders contribute substantially to medical and occupational morbidity. The role of fitness and physical activity in the prevention of mental health disorders is not well established, but epidemiologic data suggest that physical activity can protect against anxiety and depression. Method: The analyses presented in this report, from a prospective cohort study, evaluate the association between fitness (as measured by a 5-minute step test), and being overweight (defined as exceeding weight and body fat allowances) at military entrance, with subsequent onset of mental disorder diagnosis in the first year of service. The association between risk factors and mental disorder diagnosis was analyzed using multivariate Poisson regression with the adjusted incidence rate ratio (aIRR) as the measure of association. Results: Among weight-qualified participants, factors associated with increased incidence of mental disorder included failing the physical fitness test (aIRR: 1.36, p < 0.0001), female sex (aIRR: 2.17, p < 0.0001), and smoking (aIRR: 1.49, p < 0.0001). Among fit participants, being overweight was not significantly associated with mental disorder (aIRR: 1.11, p = 0.1540). Conclusions: This test has potential military utility as an adjunct part of the medical examination process. Additional research is needed among civilians to determine if similar associations exist. If so, intervention studies should be conducted to determine if improving physical fitness reduces subsequent psychiatric disorder risk, particularly among young adults entering into stressful situations. Published by Elsevier Inc. C1 [Gubata, Marlene E.; Urban, Nadia; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, Silver Spring, MD 20910 USA. [Urban, Nadia; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM Marlene.Gubata@us.army.mil FU US Army Accession Command FX This study was funded by the US Army Accession Command. NR 60 TC 11 Z9 11 U1 3 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD JUL PY 2013 VL 75 IS 1 BP 43 EP 48 DI 10.1016/j.jpsychores.2013.04.003 PG 6 WC Psychiatry SC Psychiatry GA 170CF UT WOS:000320826500007 PM 23751237 ER PT J AU Agenbroad, J AF Agenbroad, James TI Familiar skills SO LIBRARY JOURNAL LA English DT Letter C1 US Army, Res Lab, Adelphi, MD USA. RP Agenbroad, J (reprint author), US Army, Res Lab, Adelphi, MD USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2013 VL 138 IS 12 BP 11 EP 11 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 178ZA UT WOS:000321484700005 ER PT J AU Keller, DM Myhre, KE Dowben, JS Keltner, NL AF Keller, David M. Myhre, Kathryn E. Dowben, Jonathan S. Keltner, Norman L. TI Biological Perspectives: Akathisia: Ants in Your Pants SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Akathisia; aripiprazole; antichonigergics ID RATING-SCALE C1 [Keller, David M.; Dowben, Jonathan S.] Brooke Army Med Ctr, San Antonio, TX USA. [Myhre, Kathryn E.] Brooke Army Med Ctr, Adolescent & Young Adult Med Dept, San Antonio, TX USA. [Keltner, Norman L.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. RP Keltner, NL (reprint author), Univ Alabama Birmingham, Birmingham, AL 35294 USA. EM nkeltner@uab.edu NR 4 TC 0 Z9 0 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD JUL PY 2013 VL 49 IS 3 BP 149 EP 151 DI 10.1111/ppc.12032 PG 3 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 175AR UT WOS:000321202000002 PM 23819664 ER PT J AU Williams, RA Gatien, G Hagerty, BM Kane, M Otto, L Wilson, C Throop, M AF Williams, Reg Arthur Gatien, Gary Hagerty, Bonnie M. Kane, Michele Otto, Laureen Wilson, Candy Throop, Meryia TI Addressing Psychosocial Care Using an Interactive Web site for Combat-Wounded Patients SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Combat; depression; military nurses; psychosocial; PTSD; stress ID SOCIAL SUPPORT; DEPRESSION; TRIAL; VALIDITY; PROGRAM; STRESS; HEALTH; SENSE AB PURPOSE: The aims were to examine military nurses and combat-wounded patients' evaluation of a cognitive behavioral intervention Web site called Stress Gym. DESIGN AND METHODS: The use of the intervention was a proof-of-concept design with 129 military nurses and combat-wounded patients in military medical treatment facilities (MTFs). The nurses and patients logged on to Stress Gym, reviewed the nine modules available, and completed a short evaluation of the Web site. FINDINGS: The evaluation of the military nurses and patients was high. There were no significant differences in the evaluation based on military services, sex, deployment, and education levels. PRACTICE IMPLICATIONS: The strength of Stress Gym is that it enables all military members to learn about and get help with problems such as stress, anxiety, anger, and depressive symptoms anonymously and in private. CLINICAL RELEVANCE: Stress Gym is a versatile tool that can help nurses address the psychosocial needs of their patients by encouraging its use and including it in treatment protocols. C1 [Williams, Reg Arthur] Univ Michigan, Sch Med, Sch Nursing & Psychiat, Ann Arbor, MI 48109 USA. [Gatien, Gary; Hagerty, Bonnie M.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Kane, Michele] USN, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20084 USA. [Otto, Laureen] Brooke Army Med Ctr, San Antonio, TX USA. [Wilson, Candy] Wilford Hall USAF Med Ctr, San Antonio, TX USA. [Throop, Meryia] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Williams, RA (reprint author), Univ Michigan, Sch Med, Sch Nursing & Psychiat, Ann Arbor, MI 48109 USA. EM rawill@umich.edu FU TriService Nursing Research Program, Uniformed Services University of the Health Sciences; Elsie Andresen Research Fund at University of Michigan FX This paper was supported in part by the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, and Elsie Andresen Research Fund at University of Michigan; however, the information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Government. NR 33 TC 0 Z9 0 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD JUL PY 2013 VL 49 IS 3 BP 152 EP 161 DI 10.1111/j.1744-6163.2012.00344.x PG 10 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 175AR UT WOS:000321202000003 PM 23819665 ER PT J AU Buller, MJ Tharion, WJ Cheuvront, SN Montain, SJ Kenefick, RW Castellani, J Latzka, WA Roberts, WS Richter, M Jenkins, OC Hoyt, RW AF Buller, Mark J. Tharion, William J. Cheuvront, Samuel N. Montain, Scott J. Kenefick, Robert W. Castellani, John Latzka, William A. Roberts, Warren S. Richter, Mark Jenkins, Odest Chadwicke Hoyt, Reed W. TI Estimation of human core temperature from sequential heart rate observations SO PHYSIOLOGICAL MEASUREMENT LA English DT Article DE core body temperature; Kalman filter model; latent variable; core temperature surrogate; non-invasive sensors ID PHYSIOLOGICAL STRAIN; HUMAN THERMOREGULATION; BODY-TEMPERATURE; EXERCISE; STRESS; MODEL; HYPERHYDRATION; DEHYDRATION; ENVIRONMENT; SIMULATION AB Core temperature (CT) in combination with heart rate (HR) can be a good indicator of impending heat exhaustion for occupations involving exposure to heat, heavy workloads, and wearing protective clothing. However, continuously measuring CT in an ambulatory environment is difficult. To address this problem we developed a model to estimate the time course of CT using a series of HR measurements as a leading indicator using a Kalman filter. The model was trained using data from 17 volunteers engaged in a 24 h military field exercise (air temperatures 24-36 degrees C, and 42%-97% relative humidity and CTs ranging from 36.0-40.0 degrees C). Validation data from laboratory and field studies (N = 83) encompassing various combinations of temperature, hydration, clothing, and acclimation state were examined using the Bland-Altman limits of agreement (LoA) method. We found our model had an overall bias of -0.03 +/- 0.32 degrees C and that 95% of all CT estimates fall within +/- 0.63 degrees C (> 52 000 total observations). While the model for estimating CT is not a replacement for direct measurement of CT (literature comparisons of esophageal and rectal methods average LoAs of +/- 0.58 degrees C) our results suggest it is accurate enough to provide practical indication of thermal work strain for use in the work place. C1 [Buller, Mark J.; Tharion, William J.; Cheuvront, Samuel N.; Montain, Scott J.; Kenefick, Robert W.; Castellani, John; Latzka, William A.; Hoyt, Reed W.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Roberts, Warren S.] Def Sci & Technol Org, Melbourne, Vic, Australia. [Richter, Mark] Marine Corps Syst Command, Quantico, VA 22135 USA. [Buller, Mark J.; Jenkins, Odest Chadwicke] Brown Univ, Dept Comp Sci, Providence, RI 02912 USA. RP Buller, MJ (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM mark.j.buller.civ@mail.mil FU ONR PECASE Award [N000140810910] FX The views expressed in this paper are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. The following grant partially funded this research: ONR PECASE Award N000140810910. NR 35 TC 17 Z9 17 U1 1 U2 30 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0967-3334 J9 PHYSIOL MEAS JI Physiol. Meas. PD JUL PY 2013 VL 34 IS 7 BP 781 EP 798 DI 10.1088/0967-3334/34/7/781 PG 18 WC Biophysics; Engineering, Biomedical; Physiology SC Biophysics; Engineering; Physiology GA 169XV UT WOS:000320815000004 PM 23780514 ER PT J AU Shahedipour-Sandvik, F Leathersich, J Tompkins, RP Suvarna, P Tungare, M Walsh, TA Kirchner, KW Zhou, S Jones, KA AF Shahedipour-Sandvik, F. Leathersich, J. Tompkins, R. P. Suvarna, P. Tungare, M. Walsh, T. A. Kirchner, K. W. Zhou, S. Jones, K. A. TI Enhanced performance of an AlGaN/GaN high electron mobility transistor on Si by means of improved adatom diffusion length during MOCVD epitaxy SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article ID FIELD-EFFECT TRANSISTORS; GATE STRUCTURE; HEMTS; GAN; SUBSTRATE AB Four types of AlGaN/GaN high electron mobility transistor (HEMT) structures have been epitaxially grown on Si substrates by metalorganic chemical vapor deposition (MOCVD) and fabricated into devices. To achieve crack-free device structures, various stress-engineering methods have been employed including the use of AlGaN/AlGaN-graded layers, insertion of low-temperature AlN layers and ion implantation of the AlN/Si substrate. To improve material quality, pulsed MOCVD is used to enhance adatom diffusion length during (Al) GaN epitaxy of various layers in the HEMT structure. A comparison between structural and morphological characteristics of the HEMTs shows improvement in the (0 0 0 2) symmetric rocking curve value to 837.9 s(-1) and the surface roughness of 0.21 nm for HEMT structures grown using pulsed epitaxy. An OFF-state breakdown voltage of 217 V at a drain current of 1 mA mm(-1) at Vg = -8 V was measured for the structure with enhanced material quality. C1 [Shahedipour-Sandvik, F.; Leathersich, J.; Suvarna, P.; Tungare, M.] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. [Tompkins, R. P.; Walsh, T. A.; Kirchner, K. W.; Zhou, S.; Jones, K. A.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Shahedipour-Sandvik, F (reprint author), SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. EM sshahedipour-sandvik@albany.edu FU ARO [W911NF0920070]; National Science Foundation (NSF) [0904929] FX This work is supported in part by ARO under award number W911NF0920070 and by the National Science Foundation (NSF) under award number 0904929. NR 31 TC 4 Z9 4 U1 1 U2 50 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD JUL PY 2013 VL 28 IS 7 SI SI AR 074002 DI 10.1088/0268-1242/28/7/074002 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 168PH UT WOS:000320717500003 ER PT J AU Moran, DS McClung, JP Kohen, T Lieberman, HR AF Moran, Daniel S. McClung, James P. Kohen, Tal Lieberman, Harris R. TI Vitamin D and Physical Performance SO SPORTS MEDICINE LA English DT Review ID ALL-CAUSE MORTALITY; RANDOMIZED CONTROLLED-TRIALS; 25-HYDROXYVITAMIN D LEVELS; BONE-MINERAL DENSITY; YOUNG FINNISH MEN; D DEFICIENCY; D SUPPLEMENTATION; STRESS-FRACTURES; SKELETAL-MUSCLE; D-RECEPTOR AB Vitamin D is an essential nutrient obtained from the diet and exposure to sunlight. Roles for vitamin D have been established in the function of the cardiovascular, immune, and musculoskeletal systems. An electronic database search was conducted using EMBASE (1967 to August 2012), MEDLINE (1966 to August 2012), SPORTDiscus (TM) (1975 to August 2012), and the Scientific Electronic Library Online (SciELO) (1998 to August 2012) with no limits of language of publication. Articles that described vitamin D and performance were considered eligible for this review. Recent studies suggest that vitamin D maintains physical performance in athletes and other active populations, e.g., maximal oxygen consumption may be related to vitamin D status. Poor vitamin D status affects muscle strength, and vitamin D may participate in protein synthesis through the actions of the vitamin D receptor in muscle tissue. Vitamin D may protect against overuse injuries, such as stress fracture, through its well-documented role in calcium metabolism. The objective of this manuscript is to review recent evidence regarding the importance of vitamin D for maintaining physical performance, and includes specific examples of how vitamin D supports the cardiovascular, immune, and musculoskeletal systems. C1 [Moran, Daniel S.] USA, Environm Med Res Inst, Oak Ridge Inst Sci & Educ Program, Natick, MA 01760 USA. [Moran, Daniel S.; Kohen, Tal] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, Daniel S.] Ariel Univ, Ariel, Israel. [McClung, James P.; Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il RI McClung, James/A-1989-2009 FU appointment to the Research Participation Program at the US Army Medical Research Institute of Environmental Medicine FX This research was supported in part by an appointment to the Research Participation Program at the US Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and US Army Medical Research and Materiel Command. The authors are aware of no conflicts of interest that are directly relevant to the content of this review. NR 132 TC 14 Z9 14 U1 5 U2 39 PU ADIS INT LTD PI NORTHCOTE PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND SN 0112-1642 EI 1179-2035 J9 SPORTS MED JI Sports Med. PD JUL PY 2013 VL 43 IS 7 BP 601 EP 611 DI 10.1007/s40279-013-0036-y PG 11 WC Sport Sciences SC Sport Sciences GA 170YE UT WOS:000320890300007 PM 23657931 ER PT J AU Kijak, GH Tovanabutra, S Rerks-Ngarm, S Nitayaphan, S Eamsila, C Kunasol, P Khamboonruang, C Thongcharoen, P Namwat, C Premsri, N Benenson, M Morgan, P Bose, M Sanders-Buell, E Paris, R Robb, ML Birx, DL De Souza, MS McCutchan, FE Michael, NL Kim, JH AF Kijak, Gustavo H. Tovanabutra, Sodsai Rerks-Ngarm, Supachai Nitayaphan, Sorachai Eamsila, Chirapa Kunasol, Prayura Khamboonruang, Chirasak Thongcharoen, Prasert Namwat, Chawetsan Premsri, Nakorn Benenson, Michael Morgan, Patricia Bose, Meera Sanders-Buell, Eric Paris, Robert Robb, Merlin L. Birx, Deborah L. De Souza, Mark S. McCutchan, Francine E. Michael, Nelson L. Kim, Jerome H. TI Molecular Evolution of the HIV-1 Thai Epidemic between the Time of RV144 Immunogen Selection to the Execution of the Vaccine Efficacy Trial SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; INJECTING DRUG-USERS; CIRCULATING RECOMBINANT FORM; HIGH-RISK POPULATIONS; FEMALE SEX WORKERS; PHASE-III TRIAL; NORTHERN THAILAND; SUBTYPE-E; CRF01-AE/B RECOMBINANT; GENETIC COMPLEXITY AB The RV144 HIV-1 vaccine trial (Thailand, 2003 to 2009), using immunogens genetically matched to the regional epidemic, demonstrated the first evidence of efficacy for an HIV-1 vaccine. Here we studied the molecular evolution of the HIV-1 epidemic from the time of immunogen selection to the execution of the efficacy trial. We studied HIV-1 genetic diversity among 390 volunteers who were deferred from enrollment in RV144 due to preexisting HIV-1 infection using a multiregion hybridization assay, full-genome sequencing, and phylogenetic analyses. The subtype distribution was 91.7% CRF01_AE, 3.5% subtype B, 4.3% B/CRF01_AE recombinants, and 0.5% dual infections. CRF01_AE strains were 31% more diverse than the ones from the 1990s Thai epidemic. Sixty-nine percent of subtype B strains clustered with the cosmopolitan Western B strains. Ninety-three percent of B/CRF01_AE recombinants were unique; recombination breakpoint analysis showed that these strains were highly embedded within the larger network that integrates recombinants from East/Southeast Asia. Compared to Thai sequences from the early 1990s, the distance to the RV144 immunogens increased 52% to 68% for CRF01_AE Env immunogens and 12% to 29% for subtype B immunogens. Forty-three percent to 48% of CRF01_AE sequences differed from the sequence of the vaccine insert in Env variable region 2 positions 169 and 181, which were implicated in vaccine sieve effects in RV144. In conclusion, compared to the molecular picture at the early stages of vaccine development, our results show an overall increase in the genetic complexity of viruses in the Thai epidemic and in the distance to vaccine immunogens, which should be considered at the time of the analysis of the trial results. C1 [Kijak, Gustavo H.; Tovanabutra, Sodsai; Bose, Meera; Sanders-Buell, Eric; Robb, Merlin L.; De Souza, Mark S.; McCutchan, Francine E.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20814 USA. [Kijak, Gustavo H.; Tovanabutra, Sodsai; Bose, Meera; Sanders-Buell, Eric; Robb, Merlin L.; Birx, Deborah L.; McCutchan, Francine E.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Rerks-Ngarm, Supachai; Kunasol, Prayura; Khamboonruang, Chirasak; Thongcharoen, Prasert; Namwat, Chawetsan; Premsri, Nakorn] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Nitayaphan, Sorachai; Eamsila, Chirapa; Kunasol, Prayura; Benenson, Michael; Morgan, Patricia; Paris, Robert; De Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Kijak, GH (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20814 USA. EM gkijak@hivresearch.org FU U.S. Army Medical Research and Materiel Command [Y1-AI- 2642-12]; National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine; U.S. Department of Defense FX This work was supported in part by an Interagency Agreement (Y1-AI- 2642-12) between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. NR 85 TC 14 Z9 14 U1 1 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUL PY 2013 VL 87 IS 13 BP 7265 EP 7281 DI 10.1128/JVI.03070-12 PG 17 WC Virology SC Virology GA 160JT UT WOS:000320116500007 PM 23576510 ER PT J AU Mamisashvili, E Kracalik, IT Onashvili, T Kerdzevadze, L Goginashvili, K Tigilauri, T Donduashvili, M Nikolaishvili, M Beradze, I Zakareishvili, M Kokhreidze, M Gelashvili, M Vepkhvadze, N Racz, SE Elzer, PH Nikolich, MP Blackburn, JK AF Mamisashvili, Eliso Kracalik, Ian T. Onashvili, Tinatin Kerdzevadze, Lela Goginashvili, Ketevan Tigilauri, Tamar Donduashvili, Marina Nikolaishvili, Marina Beradze, Irma Zakareishvili, Marina Kokhreidze, Maka Gelashvili, Makvala Vepkhvadze, Nino Racz, S. Elizabeth Elzer, Philip H. Nikolich, Mikeljon P. Blackburn, Jason K. TI Seroprevalence of brucellosis in livestock within three endemic regions of the country of Georgia SO PREVENTIVE VETERINARY MEDICINE LA English DT Article DE Brucellosis; Livestock; Georgia; Serology; True prevalence ID EPIDEMIOLOGY AB Brucellosis is the one of most common livestock zoonoses in Georgia, resulting in significant economic losses. Livestock were sampled in three regions of Georgia (Kakheti, Kvemo Kartli, Imereti). Districts that historically reported high numbers of brucellosis related morbidity were selected for serological, bacteriological and molecular surveys. Surveying efforts yielded samples from 10,819 large and small ruminants. In total, 735 serological tests were positive on Rose Bengal and 33 bacterial isolates were recovered and identified as Brucella melitensis or Brucella abortus by microbiology and AMOS-PCR. A Bayesian framework was implemented to estimate the true prevalence of the disease given an imperfect diagnostic test. Regional posterior median true prevalence estimates ranged from 2.7% (95% CI: 1.4, 7.2) in Kvemo Kartli, 0.8% (95% CI: 0.0, 3.6) in Kakheti, to an estimate of 0.6% (95% CI: 0.0, 2.9) in Imereti. Accurate and efficient surveillance of brucellosis is not only of economic value, but also informs efforts to reduce the disease impact on the human population. (C) 2012 Elsevier B.V. All rights reserved. C1 [Mamisashvili, Eliso; Onashvili, Tinatin; Kerdzevadze, Lela; Goginashvili, Ketevan; Tigilauri, Tamar; Donduashvili, Marina; Nikolaishvili, Marina; Beradze, Irma; Zakareishvili, Marina; Kokhreidze, Maka; Gelashvili, Makvala; Vepkhvadze, Nino] Lab Minist Agr, Tbilisi, Rep of Georgia. [Kracalik, Ian T.; Blackburn, Jason K.] Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA. [Racz, S. Elizabeth] Univ Nebraska, HW Manter Lab, Lincoln, NE USA. [Elzer, Philip H.] LSU AgCenter, Dept Vet Sci, Baton Rouge, LA 70803 USA. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Blackburn, JK (reprint author), Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA. EM jkblackburn@ufl.edu FU US Defense Threat Reduction Agency [GG-17]; DTRA Joint University Partnership; Penn State FX This work was supported by the US Defense Threat Reduction Agency through the Cooperative Biological Engagement Program CBR Project GG-17. ITK, PE and JKB are funded through the DTRA Joint University Partnership administered through the University of New Mexico and Penn State. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the U.S. Army, or the Department of Defense. NR 12 TC 1 Z9 1 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-5877 J9 PREV VET MED JI Prev. Vet. Med. PD JUL 1 PY 2013 VL 110 IS 3-4 BP 554 EP 557 DI 10.1016/j.prevetmed.2012.12.005 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA 164RL UT WOS:000320427100028 PM 23287714 ER PT J AU Pedahzur, A Perliger, A AF Pedahzur, Ami Perliger, Arie TI Comment on "Religious Violence in Judaism: Past and Present" by Gideon Aran and Ron E. Hassner SO TERRORISM AND POLITICAL VIOLENCE LA English DT Article C1 [Pedahzur, Ami] Univ Texas Austin, Dept Govt, Austin, TX 78712 USA. [Perliger, Arie] US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA. [Perliger, Arie] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Pedahzur, A (reprint author), Univ Texas Austin, Dept Govt, MEZ 3-140,Campus Mail Code A1800, Austin, TX 78712 USA. EM pedahzur@austin.utexas.edu NR 1 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-6553 J9 TERROR POLIT VIOLENC JI Terror. Polit. Violence PD JUL 1 PY 2013 VL 25 IS 3 BP 413 EP 415 DI 10.1080/09546553.2012.667744 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 161WI UT WOS:000320223600005 ER PT J AU Schumacher, FR Wang, ZM Skotheim, RI Koster, R Chung, CC Hildebrandt, MAT Kratz, CP Bakken, AC Bishop, DT Cook, MB Erickson, RL Fossa, SD Greene, MH Jacobs, KB Kanetsky, PA Kolonel, LN Loud, JT Korde, LA Le Marchand, L Lewinger, JP Lothe, RA Pike, MC Rahman, N Rubertone, MV Schwartz, SM Siegmund, KD Skinner, EC Turnbull, C Van den Berg, DJ Wu, XF Yeager, M Nathanson, KL Chanock, SJ Cortessis, VK McGlynn, KA AF Schumacher, Fredrick R. Wang, Zhaoming Skotheim, Rolf I. Koster, Roelof Chung, Charles C. Hildebrandt, Michelle A. T. Kratz, Christian P. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fossa, Sophie D. Greene, Mark H. Jacobs, Kevin B. Kanetsky, Peter A. Kolonel, Laurence N. Loud, Jennifer T. Korde, Larissa A. Le Marchand, Loic Lewinger, Juan Pablo Lothe, Ragnhild A. Pike, Malcolm C. Rahman, Nazneen Rubertone, Mark V. Schwartz, Stephen M. Siegmund, Kimberly D. Skinner, Eila C. Turnbull, Clare Van den Berg, David J. Wu, Xifeng Yeager, Meredith Nathanson, Katherine L. Chanock, Stephen J. Cortessis, Victoria K. McGlynn, Katherine A. TI Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23 SO HUMAN MOLECULAR GENETICS LA English DT Article ID CANCER; RISK; GENES; POLYMORPHISMS; METABOLISM; EXPRESSION; VARIANTS; RECEPTOR; URIDINE; TRENDS AB Genome-wide association studies (GWASs) have identified multiple common genetic variants associated with an increased risk of testicular germ cell tumors (TGCTs). A previous GWAS reported a possible TGCT susceptibility locus on chromosome 1q23 in the UCK2 gene, but failed to reach genome-wide significance following replication. We interrogated this region by conducting a meta-analysis of two independent GWASs including a total of 940 TGCT cases and 1559 controls for 122 single-nucleotide polymorphisms (SNPs) on chromosome 1q23 and followed up the most significant SNPs in an additional 2202 TGCT cases and 2386 controls from four casecontrol studies. We observed genome-wide significant associations for several UCK2 markers, the most significant of which was for rs3790665 (P-Combined 6.0 10(9)). Additional support is provided from an independent familial study of TGCT where a significant over-transmission for rs3790665 with TGCT risk was observed (P-FBAT 2.3 10(3)). Here, we provide substantial evidence for the association between UCK2 genetic variation and TGCT risk. C1 [Schumacher, Fredrick R.; Lewinger, Juan Pablo; Siegmund, Kimberly D.; Van den Berg, David J.; Cortessis, Victoria K.] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA. [Wang, Zhaoming; Chung, Charles C.; Cook, Michael B.; Greene, Mark H.; Jacobs, Kevin B.; Loud, Jennifer T.; Korde, Larissa A.; Yeager, Meredith; Chanock, Stephen J.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Wang, Zhaoming; Jacobs, Kevin B.; Yeager, Meredith] NCI Frederick, Canc Genome Res Lab, Div Canc Epidemiol & Genet, Adv Technol Program,SAIC Frederick Inc, Frederick, MD USA. [Skotheim, Rolf I.; Bakken, Anne C.; Lothe, Ragnhild A.] Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Canc Prevent, Oslo, Norway. [Skotheim, Rolf I.; Bakken, Anne C.; Lothe, Ragnhild A.] Univ Oslo, Fac Med, Ctr Canc Biomed, Oslo, Norway. [Koster, Roelof; Nathanson, Katherine L.] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Hildebrandt, Michelle A. T.; Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Kratz, Christian P.] Hannover Med Sch, Dept Pediat Hematol & Oncol, Ctr Pediat & Adolescent Med, Hannover, Germany. [Bishop, D. Timothy] St James Univ Hosp, Canc Res UK Clin Ctr Leeds, Leeds Inst Mol Med, Epidemiol & Biostat Sect, Leeds LS9 7TF, W Yorkshire, England. [Erickson, R. Loren] Walter Reed Army Inst Res, Silver Spring, MD USA. [Fossa, Sophie D.] Univ Oslo, Norwegian Radium Hosp, Oslo Univ Hosp, Dept Oncol, Oslo, Norway. [Kolonel, Laurence N.; Le Marchand, Loic] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA. [Korde, Larissa A.] Univ Washington, Div Med Oncol, Seattle Canc Care Alliance, Seattle, WA 98195 USA. [Pike, Malcolm C.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Rahman, Nazneen; Turnbull, Clare] Inst Canc Res, Div Canc Genet, Sutton, Surrey, England. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. [Schwartz, Stephen M.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Schwartz, Stephen M.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Skinner, Eila C.] Stanford Univ, Dept Urol, Stanford, CA 94305 USA. RP Chanock, SJ (reprint author), NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. EM preethi.raj@nih.gov; mcglynnk@mail.nih.gov RI Cook, Michael/A-5641-2009; Koster, Roelof/E-2158-2016; OI Cook, Michael/0000-0002-0533-7302; Koster, Roelof/0000-0003-1424-8579; Schwartz, Stephen/0000-0001-7499-8502; Nathanson, Katherine/0000-0002-6740-0901; Bishop, Tim/0000-0002-8752-8785 FU Intramural Research Program of the National Cancer Institute; Westat, Inc.; California Cancer Research Program [99-00505V-10260, 03-00174VRS-30021]; National Cancer Institute [1R01 CA102042-01A1]; Whittier Foundation; Abramson Cancer Center at the University of Pennsylvania; National Institutes of Health [R01CA114478, R01CA085914]; MD Anderson Senior Research Trust Fellowship; Movember; Cancer Research UK; [HHSN261200655004C] FX A portion of this work was supported by the Intramural Research Program of the National Cancer Institute and by support services contract HHSN261200655004C with Westat, Inc. Support was also provided as follows: USC GWAS controls were supported by the Multiethnic Cohort Study (NCI U01-CA98758). USC GWAS testicular cases and Familial Study were supported by the California Cancer Research Program (99-00505V-10260, 03-00174VRS-30021) and National Cancer Institute (1R01 CA102042-01A1) grants to V. K. C. and a Whittier Foundation award to the Norris Comprehensive Cancer Center. Replication effort for the TestPAC study was supported by the Abramson Cancer Center at the University of Pennsylvania and National Institutes of Health grant R01CA114478 to P. A. K. and K.L.N. Replication effort for the ATLAS study was supported by the National Institutes of Health grant R01CA085914 to S. M. S. MD Anderson: Center for Translational and Public Health Genomics of the Duncan Family Institute for Cancer Prevention and Risk Assessment and by MD Anderson Senior Research Trust Fellowship to X. W. The UK Genetics of Testicular Cancer Study was supported by Movember and Cancer Research UK. NR 33 TC 28 Z9 29 U1 0 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0964-6906 J9 HUM MOL GENET JI Hum. Mol. Genet. PD JUL 1 PY 2013 VL 22 IS 13 BP 2748 EP 2753 DI 10.1093/hmg/ddt109 PG 6 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA 160MZ UT WOS:000320125100017 PM 23462292 ER PT J AU Lu, SX Fiorini, T Lee, J Prasad, HS Buxton, AN Bisch, FC Dixon, DR Susin, C Wikesjo, UME AF Lu, Sheldon X. Fiorini, Tiago Lee, Jaebum Prasad, Hari S. Buxton, Amanda N. Bisch, Fredrick C. Dixon, Douglas R. Susin, Cristiano Wikesjoe, Ulf M. E. TI Evaluation of a compression resistant matrix for recombinant human bone morphogenetic protein-2 SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE biomaterials; bone; bone morphogenetic protein; osseointegration; tissue engineering ID ALVEOLAR RIDGE AUGMENTATION; IMPLANT DEFECT MODEL; HISTOLOGIC OBSERVATIONS; CLINICAL-IMPLICATIONS; GRINDING TECHNIQUE; NONHUMAN-PRIMATES; TITANIUM IMPLANTS; BULKING AGENT; SPINE FUSION; BETA FAMILY AB Background Previous studies document the therapeutic potential of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier for indications in the axial and appendicular skeleton. Nevertheless, the ACS does not comprise structural integrity to adequately support bone formation for onlay indications. The objective of this study was to evaluate local bone formation and osseointegration following surgical implantation of rhBMP-2 soak-loaded onto a compression resistant matrix (CRM). Methods Routine, contralateral, critical-size, supraalveolar, peri-implant defects in five adult male Hound Labrador mongrel dogs received 0.8mg rhBMP-2 soak-loaded onto either the ACS (benchmark control) or a CRM (collagen/-TCP/hydroxyapatite) followed by submerged wound closure for primary intention healing. The animals were euthanized at 8weeks for histologic/histometric evaluation. Results Healing was uneventful albeit considerable initial swelling was observed for either treatment. Sites receiving rhBMP-2/CRM showed significantly increased bone area (20.0 +/- 0.9 versus 12.3 +/- 2.6mm2, p=0.03) and bone density (24.1 +/- 1.4% versus 14.6 +/- 2.0%, p=0.04) compared with those receiving rhBMP-2/ACS. There were no significant differences between treatments for new bone height and osseointegration. Woven and lamellar trabecular bone lined with abundant osteoid was observed for all sites. Inconsistent cortex formation confirmed the immature nature of the newly formed bone. Seroma formation was observed for both treatments (80-100% of the animals/implants). Sites receiving rhBMP-2/CRM showed residual ceramic granules undergoing biodegradation, including accumulation of foamy macrophages. Conclusions rhBMP-2/CRM supports bone formation of clinically relevant geometry. Longer observation intervals as well as dose variations appear necessary to capture maturation of the newly formed bone, elimination of residual ceramic granules and resolution of seroma formation(s). C1 [Lu, Sheldon X.; Fiorini, Tiago; Lee, Jaebum; Susin, Cristiano; Wikesjoe, Ulf M. E.] Georgia Regents Univ, LAPCR, Coll Dent Med, Augusta, GA 30912 USA. [Prasad, Hari S.] Univ Minnesota, Hard Tissue Res Lab, Minneapolis, MN USA. [Buxton, Amanda N.] Medtron Spinal, Biol, Memphis, TN USA. [Lu, Sheldon X.; Bisch, Fredrick C.; Dixon, Douglas R.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. RP Wikesjo, UME (reprint author), Georgia Regents Univ, LAPCR, Coll Dent Med, 1120,15th St AD-1430, Augusta, GA 30912 USA. EM uwikesjo@gru.edu RI Susin, Cristiano/B-9822-2008; Wikesjo, Ulf/A-4159-2009 OI Wikesjo, Ulf/0000-0003-1607-0583 FU Nobel Biocare AB; Non-Tenured Faculty Grant from 3M; US Army Dental Command; Fort Gordon DEN-TAC FX Drs. Ulf ME Wikesjo, Cristiano Susin and Jaebum Lee have received research grants unrelated to this work from Wyeth Research, Medtronic - Spinal, and Nobel Biocare AB. Drs. Wikesjo, Susin and Lee are supported in part by a grant from Nobel Biocare AB. Dr. Wikesjo was part of the team at Genetics Institute (Wyeth Research) that provided the evidence and background for the development and registration of rhBMP-2. Dr. Susin is also supported in part by a Non-Tenured Faculty Grant from 3M. Dr. Amanda N. Buxton is an employee for Medtronic - Spinal. All other authors declare no conflict of interest. This research was funded in part by the US Army Dental Command and the Fort Gordon DEN-TAC. Medtronic - Spinal and Nobel Biocare AB provided materials used in this study. NR 51 TC 10 Z9 10 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD JUL PY 2013 VL 40 IS 7 BP 688 EP 697 DI 10.1111/jcpe.12109 PG 10 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 157MN UT WOS:000319900500005 PM 23627347 ER PT J AU Nie, JF Agnew, S Mathaudhu, S AF Nie, J. F. Agnew, Sean Mathaudhu, Suveen TI Foreword Symposium on Phase Transformations and Deformation in Magnesium Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Editorial Material C1 [Nie, J. F.] Monash Univ, Dept Mat Engn, Clayton, Vic 3168, Australia. [Agnew, Sean] Univ Virginia, Dept Mat Sci & Engn, Charlottesville, VA USA. [Mathaudhu, Suveen] USA, Div Mat Sci, Res Off, Durham, NC USA. RP Nie, JF (reprint author), Monash Univ, Dept Mat Engn, Clayton, Vic 3168, Australia. EM jianfeng.nie@monash.edu RI Mathaudhu, Suveen/B-4192-2009 NR 0 TC 0 Z9 0 U1 0 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JUL PY 2013 VL 44A IS 7 BP 2917 EP 2917 DI 10.1007/s11661-013-1713-z PG 1 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 150VZ UT WOS:000319420800004 ER PT J AU de Guzman, R Polykratis, IA Sondeen, JL Darlington, DN Cap, AP Dubick, MA AF de Guzman, Rodolfo, Jr. Polykratis, I. Amy Sondeen, Jill L. Darlington, Daniel N. Cap, Andrew P. Dubick, Michael A. TI STABILITY OF TRANEXAMIC ACID AFTER 12-WEEK STORAGE AT TEMPERATURES FROM-20 degrees C TO 50 degrees C SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE tranexamic acid; temperature stability; HPLC; thromboelastography; storage ID EARLY COAGULOPATHY; COMBAT CASUALTIES; CONTROLLED-TRIAL; TRAUMA PATIENTS; HYPERFIBRINOLYSIS; MORTALITY; THROMBOLYSIS; CRASH-2; DEATH AB Background. Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss during surgery, decreases mortality in civilian and military trauma populations, was adopted for prehospital use by the British military, and is now issued to U. S. Special Operations Forces for use on the battlefield. Objective. This study tested whether storage of TXA ampoules at four temperatures (-20 degrees C, 4 degrees C, 22 degrees C, or 50 degrees C) for 1, 2, 4, and 12 weeks would result in chemical degradation and the loss of activity to block streptokinaseinduced fibrinolysis in human plasma. Methods. For each temperature and storage duration, normal plasma, plasma plus streptokinase (SK) (50 units/mL), and plasma + SK + TXA (0.2 mu g/mL, n = 4) were tested for D-dimer (DD), for fibrin degradation products (FDP), by thromboelastography (to measure the units/mL of SK needed to get 100% fibrinolysis at 60 minutes [LY60]), and by high-performance liquid chromatography (HPLC). The results were similar for all temperatures and storage durations, and were therefore combined. Results. Streptokinase led to a rise in LY60, DD, and FDP that was significantly (p < 0.05) attenuated with TXA. The results in the three test conditions were LY60: 0.00% +/- 0.00%, 70.52% +/- 4.7%, 0.02% +/- 0.01%; DD: 0.23 +/- 0.1, 205.05 +/- 101.59, 0.31 +/- 0.01 mg/L; and FDP: < 10, > 40, and < 10 mu g/mL, respectively. The HPLC results showed no chemical breakdown of TXA. All TXA glass ampoules at -20 degrees C were cracked by week 1. Conclusions. Except for the finding that TXA ampoules cracked when frozen, this study indicated that the drug remains effective when stored under conditions likely to be encountered in the prehospital environment and outside the manufacturer's recommended temperature range for at least 12 weeks. C1 [de Guzman, Rodolfo, Jr.; Polykratis, I. Amy; Sondeen, Jill L.; Darlington, Daniel N.; Cap, Andrew P.; Dubick, Michael A.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Sondeen, JL (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, San Antonio, TX 78234 USA. EM Jill.L.Sondeen.CIV@mail.mil FU US Army Medical Research and Materiel Command FX This study was supported by the US Army Medical Research and Materiel Command. NR 30 TC 8 Z9 8 U1 0 U2 12 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JUL-SEP PY 2013 VL 17 IS 3 BP 394 EP 400 DI 10.3109/10903127.2013.792891 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 157HF UT WOS:000319886200015 PM 23734991 ER PT J AU Trabert, B Graubard, BI Erickson, RL Zhang, YW McGlynn, KA AF Trabert, Britton Graubard, Barry I. Erickson, Ralph L. Zhang, Yawei McGlynn, Katherine A. TI Second to fourth digit ratio, handedness and. testicular germ cell tumors SO EARLY HUMAN DEVELOPMENT LA English DT Article DE Case-control; Testicular cancer; Hand pattern; Left-handed dominance; Digit ratio ID BREAST-CANCER RISK; 2D 4D; WOMEN; TESTOSTERONE; LENGTH; COHORT; DIETHYLSTILBESTROL; LATERALIZATION; LANGUAGE; SIZE AB Background: Research on early life exposures and testicular germ cell tumors (TGCT) risk has focused on a possible perinatal etiology with a well-known hypothesis suggesting that hormonal involvement during fetal life is associated with risk. Second-to-fourth digit ratio (2D:4D) and left-hand dominance have been proposed as markers of prenatal hormone exposure. Aim: To evaluate associations between 2D:4D digit ratio, right minus left 2D:4D (Delta(R-L)), and left-hand dominance and TGCT in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Methods: A total of 246 TGCT cases and 236 non-testicular cancer controls participated in the current study, and completed a self-administered questionnaire. Associations between digit ratio, hand dominance and TGCT were estimated using unconditional logistic regression adjusting for identified covariates. Results: Right 2D:4D was not associated with TGCT [odds ratio (OR) for a one-standard deviation (SD) increase in right-hand 2D:4D: 1.12, 95% confidence interval (CI): 0.93-1.34]. The results were consistent when evaluating the association based on the left hand. The difference between right and left-hand 2D:4D was also not associated with TGCT risk [OR for a one-SD increase in Delta(R-L): 1.03,95% CI: 0.87-1.23]. Compared to men who reported right-hand dominance, ambidexterity [OR (95% CI) = 0.65 (0.30-1.41)] and left-hand dominance [OR (95% Cl) = 0.79 (0.44-1.44)] were not associated with risk. Conclusions: These results do not support the hypothesis that prenatal hormonal imbalance is associated with TGCT risk. Given the limited sample size, further evaluation of the relationship between TGCT and prenatal hormonal factors using digit ratio, Delta(R-L), or left-hand dominance and larger sample size are warranted. Published by Elsevier Ireland Ltd. C1 [Trabert, Britton; McGlynn, Katherine A.] Natl Canc Inst, Natl Inst Hlth, Div Canc Epidemiol & Genet, Hormonal & Reprod Epidemiol Branch,DHHS, Rockville, MD 20852 USA. [Graubard, Barry I.] Natl Canc Inst, Natl Inst Hlth, Div Canc Epidemiol & Genet, Biostat Branch, Rockville, MD 20852 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Zhang, Yawei] Yale Univ, Yale Sch Publ Hlth, New Haven, CT USA. RP Trabert, B (reprint author), Natl Canc Inst, Natl Inst Hlth, Div Canc Epidemiol & Genet, Hormonal & Reprod Epidemiol Branch,DHHS, Suite 550,6120 Execut Blvd, Rockville, MD 20852 USA. EM trabertbl@mail.nih.gov RI Trabert, Britton/F-8051-2015 FU National Cancer Institute [CA130110] FX This work was supported by the Intramural Research Program of the National Cancer Institute and by grant CA130110 from the National Cancer Institute. NR 34 TC 2 Z9 2 U1 2 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-3782 J9 EARLY HUM DEV JI Early Hum. Dev. PD JUL PY 2013 VL 89 IS 7 BP 463 EP 466 DI 10.1016/j.earlhumdev.2013.04.001 PG 4 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 154YV UT WOS:000319713500004 PM 23623693 ER PT J AU Boves, TJ Kutylowski, JA Sperry, JH Cimprich, DA AF Boves, T. J. Kutylowski, J. A. Sperry, J. H. Cimprich, D. A. TI A Novel Behavior in an Endangered Species: Black-capped Vireos Reuse a Nest after Brood Parasitism and Depredation SO AMERICAN MIDLAND NATURALIST LA English DT Editorial Material ID SITE SELECTION; WOOD THRUSHES; PREDATORS; KINGBIRDS; SUCCESS; COWBIRD; CUES AB Reuse of ephemeral open cup nests by passerines is an uncommon behavior. We report the first case of nest reuse by federally endangered black-capped vireos (Vireo atricapilla). The initial use of the nest was unsuccessful because the clutch was parasitized by a brown-headed cowbird (Molothrus ater) during egg laying and then depredated during incubation. During reuse, apparently by the same pair of vireos, the nest escaped parasitism but was depredated when the nestlings were 7 d old. Although rare, this behavior may be an example of phenotypic plasticity in black-capped vireo nesting strategies. Despite failure in this instance, nest reuse may be adaptive if it reduces the risk of brood parasitism but could be maladaptive if it increases the risk of nest predation. C1 [Boves, T. J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Sperry, J. H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Cimprich, D. A.] Ft Hood Mil Reservat, Environm Div, Ft Hood, TX 76544 USA. RP Boves, TJ (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. EM tboves@illinois.edu NR 26 TC 0 Z9 0 U1 2 U2 11 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD JUL PY 2013 VL 170 IS 1 BP 191 EP 195 DI 10.1674/0003-0031-170.1.191 PG 5 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AK1WH UT WOS:000338208500015 ER PT J AU Strode, MA Bandera, BC Deveaux, P Rice, RD AF Strode, Matthew A. Bandera, Bradley C. Deveaux, Peter Rice, Robert D. TI Migrated Biliary Stent Complicated by Small Bowel Obstruction SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT Annual Scientific Meeting and Postgraduate Course Program of the Southeastern-Surgical-Congress CY FEB 09-12, 2013 CL Jacksonville, FL SP SE Surg Congress C1 [Strode, Matthew A.; Bandera, Bradley C.; Rice, Robert D.] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. [Deveaux, Peter] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA. RP Strode, MA (reprint author), 1450 Greene St,Apartment 1020, Augusta, GA 30901 USA. EM Mstrode4449@yahoo.com NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD JUL PY 2013 VL 79 IS 7 BP E253 EP E254 PG 2 WC Surgery SC Surgery GA AI6ED UT WOS:000336962600004 PM 23815993 ER PT J AU Mudge, CR Harms, NE Nachtrieb, JG AF Mudge, Christopher R. Harms, Nathan E. Nachtrieb, Julie G. TI Interactions of herbicides, surfactants, and the giant salvinia weevil (Cyrtobagous salviniae) for control of giant salvinia (Salvinia molesta) SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE biological control; chemical control; flumioxazin; foliar-applied herbicides; integrated pest management; penoxsulam AB Herbicides and the biological control agent Cyrtobagous salviniae Calder and Sands (giant salvinia weevil, Coleoptera: Curculionidae) are the most effective means to manage the floating aquatic invasive giant salvinia (Salvinia molesta Mitchell) in North America. Limited efforts have been made to integrate these technologies and no information is available on the direct and indirect impacts of herbicides on giant salvinia weevils. Flumioxazin 2-[7-Fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetra-hydro-1Hisoindole-1,3(2H)-dione and (penoxsulam) 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide, applied directly to the weevils resulted in less than 5% weevil mortality, whereas the addition of an aquatic surfactant (nonionic and buffering agent [surfactant A]) alone and in combination with the herbicides resulted in 20 to 47% giant salvinia weevil mortality. Alternate surfactants, including a methylated vegetable oil and organo-silicone blend (surfactant B), a silicone-polyether copolymer (surfactant C), and a nonionic organo-silicone blend (surfactant D) resulted in 22 to 23% mortality. In a mesocosm experiment, all weevil and herbicide treatments (alone or combination) resulted in 52 to 97% reductions in giant salvinia biomass by 4 wk after treatment (WAT). By the conclusion of the experiment (6 WAT), flumioxazin, flumioxazin plus giant salvinia weevil, and penoxsulam plus giant salvinia weevil resulted in 98 to 100% plant control. Treatment with the giant salvinia weevil alone caused a significant reduction in biomass (68%) and continued to damage plant tissue at 6 WAT. The mesocosm experiment also provided evidence of the minimal indirect impacts herbicides and surfactants will have on the giant salvinia weevil. The experiment also demonstrated that giant salvinia weevils were capable of surviving at least 4 wk on plant material treated with foliar applications of flumioxazin and penoxsulam. C1 [Mudge, Christopher R.; Harms, Nathan E.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nachtrieb, Julie G.] US Army Engineer Lewisville Aquat Ecosyst Res Fac, Lewisville, TX 75057 USA. RP Mudge, CR (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Christopher.R.Mudge@usace.army.mil FU Environmental Protection Agency (EPA) [X796433105] FX This research was supported by funds from the Environmental Protection Agency as part of the Osceola County Demonstration Project on Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL (EPA Grant ID: X796433105). We thank Jay Ferrell and Brent Sellers for their reviews of this manuscript. Mention of a trademark, proprietary product, or vendor does not constitute a guarantee or warranty of the product and does not imply its approval to the exclusion of other products or vendors that also may be suitable. NR 16 TC 1 Z9 1 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2013 VL 51 BP 77 EP 87 PG 11 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TH UT WOS:000209568000002 ER PT J AU Nachtrieb, JG AF Nachtrieb, Julie G. TI Mass-rearing Cyrtobagous salviniae for biological control of giant salvinia: Field release implications SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Editorial Material C1 [Nachtrieb, Julie G.] US Army Engineer Lewisville Aquat Ecosyst Res Fac, Lewisville, TX 75057 USA. RP Nachtrieb, JG (reprint author), US Army Engineer Lewisville Aquat Ecosyst Res Fac, 201 East Jones St, Lewisville, TX 75057 USA. EM jnachtrieb@laerf.org NR 14 TC 0 Z9 0 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2013 VL 51 BP 122 EP 126 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TH UT WOS:000209568000007 ER PT J AU Leath, CA Bevis, KS Numnum, TM Ramsey, PS Huh, WK Straughn, JM AF Leath, Charles A., III Bevis, Kerri S. Numnum, T. Michael Ramsey, Patrick S. Huh, Warner K. Straughn, J. Michael, Jr. TI Comparison of Operative Risks Associated with Radical Hysterectomy in Pregnant and Nonpregnant Women SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE cervical cancer; gynecologic surgery; hysterectomy; operative morbidity; pregnancy AB OBJECTIVE: To compare the operative data and complications of radical hysterectomy performed on pregnant women versus nonpregnant women. STUDY DESIGN: Following institutional review board approval, we reviewed our surgical databases to identify pregnant women. who had undergone a radical hysterectomy for cervical carcinoma from 1992-2005 (n = 7). A nonpregnant control group (n = 35) of women undergoing radical hysterectomy during the study interval were identified and matched for age, year of surgery, and surgeon. Pertinent operative and outcome data were abstracted and compared. RESULTS: Of the 7 women who had undergone a radical hysterectomy during pregnancy, 4 had a cesarean radical hysterectomy at a mean gestational age of 35.4 weeks (range, 32.3-38 weeks) and 3 had a radical hysterectomy with a previable fetus in situ at a mean gestational age of 14.2 weeks. Demographics were similar between groups. Transfusion rates were significantly higher among pregnant women (57%) as compared to nonpregnant controls (9%) (p = 0.0009). The overall incidence of operative complications was similar betzveen the pregnant women (43%) and nonpregnant controls (40%) (p = NS). CONCLUSION: Radical hysterectomy performed in pregnant women was associated with higher blood loss and increased need for transfusion as compared to nonpregnant controls. No differences were observed in regards to other operative surgical complications between the two groups. C1 Univ Alabama Birmingham, Dept Obstet & Gynecol, Div Gynecol Oncol, Birmingham, AL 35249 USA. Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. Tennessee Oncol PLLC, Nashville, TN USA. Texas Perinatal Grp, San Antonio, TX USA. RP Leath, CA (reprint author), Univ Alabama Birmingham, Sch Med, Dept Obstet & Gynecol, 1700 6th Ave South,Room 10250, Birmingham, AL 35249 USA. EM trey_leath@yahoo.com OI Leath III, Charles/0000-0002-4034-6845 NR 22 TC 1 Z9 2 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 EI 1943-3565 J9 J REPROD MED JI J. Reprod. Med. PD JUL-AUG PY 2013 VL 58 IS 7-8 BP 279 EP 284 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V43RA UT WOS:000209697300001 PM 23947076 ER PT J AU Gubata, ME Piccirillo, AL Packnett, ER Cowan, DN AF Gubata, Marlene E. Piccirillo, Amanda L. Packnett, Elizabeth R. Cowan, David N. TI Military Occupation and Deployment: Descriptive Epidemiology of Active Duty U.S. Army Men Evaluated for a Disability Discharge SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; US ARMY; HEALTH PROBLEMS; IRAQ; AFGHANISTAN; WAR; PERSONNEL; VETERANS; INJURY; CARE AB Objective: Physically demanding jobs and history of deployment put Soldiers at increased risk for injury, hospitalizations, and disability. Characterizing differences in disability outcomes by occupation and deployment history may identify specific military populations for targeted prevention and intervention programs as well as potential areas of future research. Methods: A cross-sectional analysis was conducted on U.S. Army enlisted men evaluated in the Department of Defense's Disability Evaluation System (DES) between fiscal years 2005 and 2011, comparing those assigned a Combat Arms military occupational specialty (MOS) to individuals with any other MOS (Other). Results: Among deployed Soldiers, those with Combat Arms MOS were substantially and significantly more likely to receive medical disability retirement than Other MOS and were more likely to be evaluated for conditions compatible with combat exposures, including post-traumatic stress disorder, residuals of traumatic brain injury, and paralysis. Among nondeployed Soldiers, Combat Arms MOS were only slightly more likely to receive medical disability than Other MOS, and no substantial differences in medical conditions were noted between the two MOS groups. Conclusions: Combat Arms MOS is a significant risk factor for disability retirement primarily among deployed men. Further research is needed to identify specific military occupations most at risk for disability retirement. C1 [Gubata, Marlene E.; Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU Defense Health Board FX This work was funded by the Defense Health Board. NR 26 TC 11 Z9 11 U1 3 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2013 VL 178 IS 7 BP 708 EP 714 DI 10.7205/MILMED-D-12-00542 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UA UT WOS:000340805300003 PM 23820342 ER PT J AU Adler, AB Delahaij, R Bailey, SM Van den Berge, C Parmak, M van Tussenbroek, B Puente, JM Landratova, S Kral, P Kreim, G Rietdijk, D McGurk, D Castro, CA AF Adler, Amy B. Delahaij, Roos Bailey, Suzanne M. Van den Berge, Carlo Parmak, Merle van Tussenbroek, Barend Puente, Jose M. Landratova, Sandra Kral, Pavel Kreim, Guenter Rietdijk, Deirdre McGurk, Dennis Castro, Carl Andrew TI NATO Survey of Mental Health Training in Army Recruits SO MILITARY MEDICINE LA English DT Article AB To-date, there has been no international review of mental health resilience training during Basic Training nor an assessment of what service members perceive as useful from their perspective. In response to this knowledge gap, the North Atlantic Treaty Organization (NATO) Human Factors & Medicine Research & Technology Task Group "Mental Health Training" initiated a survey and interview with seven to twenty recruits from nine nations to inform the development of such training (N = 121). All nations provided data from soldiers joining the military as volunteers, whereas two nations also provided data from conscripts. Results from the volunteer data showed relatively consistent ranking in terms of perceived demands, coping strategies, and preferences for resilience skill training across the nations. Analysis of data from conscripts identified a select number of differences compared to volunteers. Subjects also provided examples of coping with stress during Basic Training that can be used in future training; themes are presented here. Results are designed to show the kinds of demands facing new recruits and coping methods used to overcome these demands to develop relevant resilience training for NATO nations. C1 [Adler, Amy B.] US Army, Walter Reed Army Inst Res, Med Res Unit Europe, D-06126 Heidelberg, Germany. [Delahaij, Roos] TNO, NL-3769 ZG Soesterberg, Netherlands. [Bailey, Suzanne M.] Canadian Forces Hlth Serv Grp HQ, Directorate Mental Hlth, Ottawa, ON K1A 0K6, Canada. [Van den Berge, Carlo] Directorate Gen Human Resources, B-1120 Brussels, Belgium. [Parmak, Merle] Estonian Natl Def Coll, EE-51013 Tartu, Estonia. [van Tussenbroek, Barend] Netherlands Armed Forces, Minist Def, Mil Mental Hlth Org, Ctr Expertise, NL-3584 EZ Utrecht, Netherlands. [Puente, Jose M.] Def Med Sch, Dept Psychol, Madrid 28047, Spain. [Landratova, Sandra] Natl Armed Forces Latvia, Training & Doctrine Command, Dept Psychodiagnost, Riga, Latvia. [Kral, Pavel] Cent Mil Hosp, Cent Med Psychol Dept, Prague 16902, Czech Republic. [Kreim, Guenter] Bundesminist Verteidigung, D-53003 Bonn, Germany. [Rietdijk, Deirdre] Netherlands Armed Forces, Knowledge Ctr Mil Mental Hlth, NL-3584 EZ Utrecht, Netherlands. [McGurk, Dennis] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Castro, Carl Andrew] US Army, Mil Operat Med Res Program, Ft Detrick, MD 21702 USA. RP Adler, AB (reprint author), US Army, Walter Reed Army Inst Res, Med Res Unit Europe, Karlsruherstr 144, D-06126 Heidelberg, Germany. FU NATO [RTG 203] FX Each nation funded its own participation in the research as part of NATO RTG 203. NR 10 TC 5 Z9 7 U1 2 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2013 VL 178 IS 7 BP 760 EP 766 DI 10.7205/MILMED-D-12-00549 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UA UT WOS:000340805300011 PM 23820350 ER PT J AU Malsby, RF Quesada, J Powell-Dunford, N Kinoshita, R Kurtz, J Gehlen, W Adams, C Martin, D Shackelford, S AF Malsby, Robert F., III Quesada, Jose Powell-Dunford, Nicole Kinoshita, Ren Kurtz, John Gehlen, William Adams, Colleen Martin, Dustin Shackelford, Stacy TI Prehospital Blood Product Transfusion by U.S. Army MEDEVAC During Combat Operations in Afghanistan: A Process Improvement Initiative SO MILITARY MEDICINE LA English DT Article ID DAMAGE CONTROL RESUSCITATION; CASUALTY CARE; ENDURING-FREEDOM; IRAQI-FREEDOM; PATIENT; TRAUMA; DEATH; FORCES; WAR AB U.S. Army flight medics performed a process improvement initiative of 15 blood product transfusions on select Category A (Urgent) helicopter evacuation casualties meeting approved clinical indications for transfusion. These transfusions were initiated from point of injury locations aboard MEDEVAC aircraft originating from one of two locations in southern Afghanistan. All flight medics executing the transfusions were qualified through a standardized and approved program of instruction, which included day and night skills validation, and a 90% or higher written examination score. There was no adverse reaction or out-of-standard blood product temperature despite hazardous conditions and elevated cabin temperatures. All casualties within a 10-minute flight time who met clinical indications were transfused. Utilization of a standard operating procedure with strict handling and administration parameters, a rigorous training and qualification program, an elaborate cold chain system, and redundant documentation of blood product units ensured that flight medic initiated transfusions were safe and effective. Research study is needed to refine the indications for prehospital blood transfusion and to determine the effect on outcomes in severely injured trauma patients. C1 [Malsby, Robert F., III] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Powell-Dunford, Nicole; Kinoshita, Ren; Kurtz, John; Gehlen, William] Wheeler AAF, Schofield Barracks, HI 96857 USA. [Adams, Colleen] Walter Reed Army Med Ctr, TF Med Afghanistan Joint Enroute Crit Care Nurse, Washington, DC 20307 USA. [Martin, Dustin] 82nd Airborne Div, Ft Bragg, NC 28310 USA. [Shackelford, Stacy] Univ Maryland, Sch Med, R Adams Cowley Shock Trauma Ctr, Ctr Sustainment Trauma & Readiness Skills,USAF, Baltimore, MD 21201 USA. RP Malsby, RF (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28310 USA. NR 20 TC 14 Z9 14 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2013 VL 178 IS 7 BP 785 EP 791 DI 10.7205/MILMED-D-13-00047 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UA UT WOS:000340805300014 PM 23820353 ER PT J AU Kragh, JF Murphy, C Steinbaugh, J Dubick, MA Baer, DG Johnson, JE Henkel, CK Blackbourne, LH AF Kragh, John F., Jr. Murphy, Christopher Steinbaugh, John Dubick, Michael A. Baer, David G. Johnson, James E. Henkel, Craig K. Blackbourne, Lorne H. TI Prehospital Emergency Inguinal Clamp Controls Hemorrhage in Cadaver Model SO MILITARY MEDICINE LA English DT Article ID OPERATION-IRAQI-FREEDOM; MAJOR LIMB TRAUMA; TOURNIQUETS; DEATH AB Background: The Combat Ready Clamp is indicated to stop difficult inguinal bleeding on the battlefield, the most common type. of junctional bleeding and now the most common cause of preventable battlefield death. The purpose of the present study is to report the data of clamp development to help appliers use it correctly. Methods: Wake Forest University investigators used a cadaver model to test the clamp's ability to control hemorrhage. Ten fresh cadavers were made to simulate inguinal and popliteal wound bleeding. Blood simulant was pumped to quantify device effectiveness in testing. Points of application included proximal pressure point control of popliteal, inguinal, and bilateral bleeding. Results: Clamp use promptly controlled pulsing arterial hemorrhages from inguinal, popliteal, and bilateral wounds. The device, when placed on the common iliac artery, stopped all ipsilateral distal bleeding. Conclusions: The evidence of how the clamp works in the cadaver model showed that clamp use can plausibly be tailored to control inguinal hemorrhage from one wound, control two ipsilateral wounds with hemorrhage from one artery (e.g., common iliac artery), and control bilateral inguinal wounds (compression of the origins of bilateral common iliac arteries). C1 [Kragh, John F., Jr.; Dubick, Michael A.; Baer, David G.; Blackbourne, Lorne H.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Murphy, Christopher] Combat Med Syst LLC, Fayetteville, NC 28303 USA. [Steinbaugh, John] US Army, Special Operat Command, Ft Bragg, NC 28307 USA. [Johnson, James E.; Henkel, Craig K.] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Univ Med Ctr, Ctr Appl Learning, Winston Salem, NC 27157 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. NR 18 TC 10 Z9 11 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2013 VL 178 IS 7 BP 799 EP 805 DI 10.7205/MILMED-D-12-00495 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UA UT WOS:000340805300016 PM 23820355 ER PT J AU Kragh, JF Burrows, S Wasner, C Ritter, BA Mazuchowski, EL Brunstetter, T Johnston, KJ Diaz, GY Hodge, D Jr, HT AF Kragh, John F., Jr. Burrows, Steve Wasner, Christine Ritter, Brandi A. Mazuchowski, Edward L. Brunstetter, Tyson Johnston, Keary J. Diaz, George Y. Hodge, Douglas Harcke, H. Theodore, Jr. TI Analysis of Recovered Tourniquets From Casualties of Operation Enduring Freedom and Operation New Dawn SO MILITARY MEDICINE LA English DT Article AB Background: Tourniquet use recently became common in war, but knowledge gaps remain regarding analysis of recovered devices. The purpose of this study was to analyze tourniquets to identify opportunities for improved training. Methods: We analyzed tourniquets recovered from deceased service members serving in support of recent combat operations by a team at Dover Air Force Base from 2010 to 2012. Device makes and models, breakage, deformation, band routing, and windlass turn numbers were counted. Results: We recovered 824 tourniquets; 390 were used in care and 434 were carried unused. Most tourniquets were recommended by the Committee on Tactical Combat Casualty Care (Combat Application Tourniquet [CAT] or Special Operations Forces Tactical Tourniquet). The band was routed once through the buckle in 37% of used CATs, twice in 62%, and 1% had none. For tourniquets with data, the windlass turn number averaged 3.2 (range, 0-9). The CAT windlass turn number was associated positively with tourniquet deformation as moderate or severe deformation began at 2 turns, increased in likelihood stepwise with each turn, and became omnipresent at 7 or more. Conclusions: Tourniquet counts, band routings, windlass turn numbers, and deformation rates are candidate topics for instructors to refine training. C1 [Kragh, John F., Jr.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Burrows, Steve; Wasner, Christine; Ritter, Brandi A.; Brunstetter, Tyson; Johnston, Keary J.; Diaz, George Y.; Hodge, Douglas] Force Hlth Protect & Readiness FHP&R, Off Assistant Secretary Def Hlth Affairs, Def Med Mat Program Off DMMPO, Ft Detrick, MD 21702 USA. [Mazuchowski, Edward L.; Harcke, H. Theodore, Jr.] Armed Forces Med Examiner Syst, Dover Air Force Base, DE 19902 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,Bldg BHT-2,Room 222-4, Ft Sam Houston, TX 78234 USA. FU Defense Health Board [201105]; National Institutes of Health; Food and Drug Administration FX The authors thank Otilia Sanchez, who aided in manuscript preparation. Financial disclosures that might relate to this work: Dr. Kragh is an employee of the U.S. Government and receives institutional support where he works, the U.S. Army Institute of Surgical Research. Noninstitutional support occasionally comes from other governmental agencies such as the Defense Health Program and the U.S. Army Medical Research and Materiel Command for specific projects or related work. He has offered free advice on scientific matters at no cost to Operative Experience, M2, Tiger Surgical LLC, Tactical Medical Solutions LLC, Combat Medical Systems, Composite Resources, Delfi Medical Innovations, North American Rescue Products LLC, H & H Associates, Creative & Effective Technologies, TEMS Solutions LLC, Blackhawk Products Group, Hemaclear, Tactical Development Group, Compression Works LLC, Tier-One Quality Solutions, Kforce Government Solutions, CHI Systems, Tactical Emergency And Medical Simulations Training (TeamsT), Athena GTX, Pelagique LLC, Hawaii Product Development, RevMedx, SAM Medical Products, Speer Operational Technologies, and Entrotech. He has received payment (special government employee) for occasional work for the Food and Drug Administration for device consultation (510 k panelist). In 2007, he received some funds for work for the National Institutes of Health. He has received honoraria for trustee work for the nonprofit Musculoskeletal Transplant Foundation. He has worked as a technical representative to the U.S. Government's contracting officer in agreements with Physical Optics Corporation, Resodyn Corporation, International Heart Institute of Montana Foundation, Daemen College, Noble Biomaterials, Wake Forest Institute of Regenerative Medicine, National Tissue Engineering Center, Pittsburgh Tissue Engineering Initiative, University of Texas Southwestern Medical Center, Arteriocyte, and Kelly Space and Technology. Funding is internal to each organization. Funding for Dr. Kragh's portion of the work was provided in part by the Defense Health Board (proposal 201105: Operational system management and post-market surveillance of hemorrhage control devices used in medical care of U.S. servicepersons in the current war). NR 3 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2013 VL 178 IS 7 BP 806 EP 810 DI 10.7205/MILMED-D-12-00491 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UA UT WOS:000340805300017 PM 23820356 ER PT J AU Tsai, AY Dueger, E Macalino, GE Montano, SM Mbuchi, M Puplampu, N McClelland, RS Sanchez, JL AF Tsai, A. Y. Dueger, E. Macalino, G. E. Montano, S. M. Mbuchi, M. Puplampu, N. McClelland, R. S. Sanchez, J. L. TI NEISSERIA GONORRHOEAE (GC) RESISTANCE SURVEILLANCE IN SELECTED POPULATIONS OF FIVE COUNTRIES SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Meeting Abstract C1 [Tsai, A. Y.; Sanchez, J. L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Tsai, A. Y.] US Army Publ Hlth Command, Postgrad Res Participat Program, Oak Ridge Inst Sci & Educ, Aberdeen Proving Ground, MD USA. [Dueger, E.] US Naval Med Res Unit 3, Cairo, Egypt. [Dueger, E.] US Ctrs Dis Control & Prevent CDC, Global Dis Detect Branch, Atlanta, GA USA. [Macalino, G. E.] Uniformed Serv Univ Hlth Sci, IDCRP, Bethesda, MD 20814 USA. [Montano, S. M.] US Naval Med Res Unit 6, Lima, Peru. [Mbuchi, M.] US Army Med Res Unit Kenya, Nairobi, Kenya. [Puplampu, N.] US Naval Med Res Unit 3 Dttachment, Accra, Ghana. [McClelland, R. S.] Univ Washington, Seattle, WA 98195 USA. [Sanchez, J. L.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 EI 1472-3263 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD JUL PY 2013 VL 89 SU 1 MA P3.276 BP A235 EP A235 DI 10.1136/sextrans-2013-051184.0732 PG 1 WC Infectious Diseases SC Infectious Diseases GA V40VR UT WOS:000209506600124 ER PT J AU Brusso, RC Orvis, KA AF Brusso, Robert C. Orvis, Karin A. TI The impeding role of initial unrealistic goal-setting on videogame-based training performance: Identifying underpinning processes and a solution SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Videogame-based training; Goal-performance discrepancy; Self-regulation; Goal-setting; Training performance ID SOCIAL-COGNITIVE THEORY; SELF-REGULATION; LEARNED HELPLESSNESS; REGULATORY PROCESSES; CAUSAL ATTRIBUTIONS; UNSOLVABLE PROBLEMS; JOB-PERFORMANCE; COMPUTER; MOTIVATION; EFFICACY AB Videogames are increasingly being used as instructional tools within education, workforce, and military contexts. Yet, additional research is needed to better understand what (and how) videogame-based training design attributes impact trainee performance in this type of training context. Goals/goal-setting and performance feedback represent two such important game design attributes. Goal-setting theory suggests that moderately difficult goals produce modest goal-performance discrepancies, which result in enhanced performance. Yet, goal-performance discrepancies are not universally beneficial. This study investigates the performance consequences of trainees setting an unrealistically difficult goal early in videogame-based training, and the mechanisms underlying this relationship. Data from 387 trainees completing a videogame-based training program demonstrated that an initial unrealistic goal, and subsequently a large goal-performance discrepancy, negatively impacts subsequent training performance. Self-regulation was examined as a mediator of this relationship: yet, was not supported, as goal-performance discrepancy failed to predict self-regulation. However, goal-performance discrepancy and videogame self-efficacy were found to interact in predicting trainees' self-regulation, suggesting more complex underlying mechanisms. This study also demonstrated that providing trainees with simple goal-setting advisement can facilitate realistic goal-setting. These findings highlight the important role of realistic goal-setting in enhancing videogame-based training effectiveness. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Brusso, Robert C.] ICF Int, Fairfax, VA 22031 USA. [Orvis, Karin A.] USA, Res Inst Behav & Social Sci, Foundat Sci Res Unit, Ft Belvoir, VA 22060 USA. [Brusso, Robert C.; Orvis, Karin A.] Old Dominion Univ, Dept Psychol, Norfolk, VA 23529 USA. RP Brusso, RC (reprint author), ICF Int, 9300 Lee Highway, Fairfax, VA 22031 USA. EM robert.brusso@icfi.com; karin.orvis@gmail.com NR 86 TC 5 Z9 5 U1 1 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 EI 1873-7692 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD JUL PY 2013 VL 29 IS 4 BP 1686 EP 1694 DI 10.1016/j.chb.2013.01.006 PG 9 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 146KO UT WOS:000319090200050 ER PT J AU Sanders-Buell, E Rutvisuttinunt, W Todd, CS Nasir, A Bradfield, A Lei, E Poltavee, K Savadsuk, H Kim, JH Scott, PT de Souza, M Tovanabutra, S AF Sanders-Buell, Eric Rutvisuttinunt, Wiriya Todd, Catherine S. Nasir, Abdul Bradfield, Andrea Lei, Esther Poltavee, Kultida Savadsuk, Hathairat Kim, Jerome H. Scott, Paul T. de Souza, Mark Tovanabutra, Sodsai TI Hepatitis C genotype distribution and homology among geographically disparate injecting drug users in Afghanistan SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE hepatitis C genotype; molecular epidemiology; HCV Type 3a; linkage cluster ID SUSTAINED VIROLOGICAL RESPONSE; HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION; HIV; PREVALENCE; EPIDEMIOLOGY; FREQUENCY; THERAPY; DISEASE AB Hepatitis C virus (HCV) prevalence is high among injecting drug users in Afghanistan, but transmission dynamics are poorly understood. Samples from HCV-infected injecting drug users were sequenced to determine circulating genotypes and potential transmission linkages. Serum samples were obtained from injecting drug user participants in Hirat, Jalalabad, and Mazar-i-Sharif between 2006 and 2008 with reactive anti-HCV rapid tests. Specimens with detected HCV viremia were amplified and underwent sequence analysis. Of 113 samples evaluated, 25 samples (35.2%) were only typeable in NS5B, nine samples (12.7%) were only typeable in CE1, and 37 samples (52.1%) were genotyped in both regions. Of those with typeable HCV, all were Afghan males with a mean age of 31.1 (standard deviation [SD]+/- 8.0) years and mean duration of injecting of 3.9 (SD +/- 4.3) years. Most reported residence outside Afghanistan in the last decade (90.1%) and prior incarceration (76.8%). HCV genotypes detected were: 1a, (35.2%, n=25), 3a (62.0%, n=44), and 1b (2.8%, n=2). Cluster formation was detected in NS5B and CE1 and were generally from within the same city. All participants within clusters reported being a refugee in Iran compared to 93.5% of those outside clusters. Only 22.2% (4/11) of those within clusters had been refugees in Pakistan and these four individuals had also been refugees in Iran. Predominance of genotype 3a and the association between HCV viremia and having been a refugee in Iran potentially reflects migration between Afghanistan and Iran among IDUs from Mazar-i-Sharif and Hirat and carry implications for harm reduction programs for this migratory population. J. Med. Virol. 85:11701179, 2013. (c) 2013 Wiley Periodicals, Inc. C1 [Sanders-Buell, Eric; Bradfield, Andrea; Lei, Esther; Kim, Jerome H.; Tovanabutra, Sodsai] Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, US Mil HIV Res Program MHRP, Silver Spring, MD USA. [Rutvisuttinunt, Wiriya; Poltavee, Kultida; Savadsuk, Hathairat; de Souza, Mark] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Todd, Catherine S.] Columbia Univ, Dept Obstet & Gynecol, New York, NY USA. [Nasir, Abdul] Int Rescue Comm, Kabul, Afghanistan. [Scott, Paul T.] Walter Reed Army Inst Res, Dept Threat Assessment & Prevent, US Mil HIV Res Program, Silver Spring, MD USA. RP Todd, CS (reprint author), PH 16-69,622 West 168th St, New York, NY 10032 USA. EM cst2121@columbia.edu FU Walter Reed Army Institute of Research; Fogarty International Center of the National Institutes of Health [K01TW007408] FX Grant sponsor: Walter Reed Army Institute of Research; Grant sponsor: Fogarty International Center of the National Institutes of Health.; Grant number: K01TW007408 NR 41 TC 8 Z9 8 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD JUL PY 2013 VL 85 IS 7 BP 1170 EP 1179 DI 10.1002/jmv.23575 PG 10 WC Virology SC Virology GA 150WY UT WOS:000319423400006 PM 23918535 ER PT J AU Mishchenko, MI Videen, G Khlebtsov, NG Wriedt, T AF Mishchenko, Michael I. Videen, Gorden Khlebtsov, Nikolai G. Wriedt, Thomas TI Comprehensive T-matrix reference database: A 2012-2013 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Electromagnetic scattering; T-matrix method; Complex scattering objects ID MULTIPLE-SCATTERING THEORY; DISCRETE DIPOLE APPROXIMATION; LIGHT-SCATTERING; ELECTROMAGNETIC SCATTERING; ATTENUATION CORRECTION; COLLOIDAL CLUSTERS; OPTICAL-PROPERTIES; DIELECTRIC BODIES; SIZE DISTRIBUTION; IRREGULAR SHAPE AB The T-matrix method is one of the most versatile, efficient, and accurate theoretical techniques widely used for numerically exact computer calculations of electromagnetic scattering by single and composite particles, discrete random media, and particles imbedded in complex environments. This paper presents the fifth update to the comprehensive database of peer-reviewed T-matrix publications initiated by us in 2004 and includes relevant publications that have appeared since 2012. It also lists several earlier publications not incorporated in the original database, including Peter Waterman's reports from the 1960s illustrating the history of the T-matrix approach and demonstrating that John Fikioris and Peter Waterman were the true pioneers of the multi-sphere method otherwise known as the generalized Lorenz-Mie theory. Published by Elsevier Ltd. C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. [Videen, Gorden] USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. [Wriedt, Thomas] Inst Werkstofftech, D-28359 Bremen, Germany. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM michael.i.mishchenko@nasa.gov RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; Pylaev, Timofey/A-8401-2016; OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov, Nikolai/0000-0002-2055-7784 FU NASA Radiation Sciences Program; NASA Remote Sensing Theory Project FX We thank Josefina Mora, Zoe Wai, and Nadia Zakharova for technical assistance. This project was sponsored by the NASA Radiation Sciences Program managed by Hal Maring and the NASA Remote Sensing Theory Project managed by Lucia Tsaoussi. NR 131 TC 20 Z9 21 U1 3 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2013 VL 123 SI SI BP 145 EP 152 DI 10.1016/j.jqsrt.2013.01.024 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 146MN UT WOS:000319095300016 ER PT J AU Jadhav, RS Chen, Q Smith, JM AF Jadhav, Ranjit S. Chen, Qin Smith, Jane M. TI Spectral distribution of wave energy dissipation by salt marsh vegetation SO COASTAL ENGINEERING LA English DT Article DE Drag coefficient; Drag force; Frequency-dependent energy dissipation; Random waves; Salt marsh vegetation; Wave damping ID POSIDONIA-OCEANICA; ATTENUATION; PROPAGATION; EMERGENT; ENGLAND AB Spectral energy dissipation of random waves due to salt marsh vegetation (Spartina alterniflora) was analyzed using field data collected during a tropical storm. Wave data (significant wave heights up to 0.4 m in 0.8 m depth) were measured over a two-day period along a 28 m transect using 3 pressure transducers. The storm produced largely bimodal spectra on the wetland, consisting of low-frequency swell (7-10 s) and high-frequency (2-4.5 s) wind-sea. The energy dissipation varied across the frequency scales with the largest magnitude observed near the spectral peaks, above which the dissipation gradually decreased. The wind-sea energy dissipated largely in the leading section of the instrument array in the wetland, but the low-frequency swell propagated to the subsequent section with limited energy loss. Across a spectrum, dissipation did not linearly follow incident energy, and the degree of non-linearity varied with the dominant wave frequency. A rigid-type vegetation model was used to estimate the frequency-dependent bulk drag coefficient. For a given spectrum, this drag coefficient increased gradually up to the peak frequency and remained generally at a stable value at the higher frequencies. This spectral variation was parameterized by employing a frequency-dependent velocity attenuation parameter inside the canopy. This parameter had much less variability among incident wave conditions, compared to the variability of the bulk drag coefficient, allowing its standardization into a single, frequency-dependent curve for velocity attenuation inside a canopy. It is demonstrated that the spectral drag coefficient predicts the frequency-dependent energy dissipation with more accuracy than the integral coefficient (C) 2013 Elsevier B.V. All rights reserved. C1 [Jadhav, Ranjit S.; Chen, Qin] Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA. [Jadhav, Ranjit S.; Chen, Qin] Louisiana State Univ, Ctr Computat & Technol, Baton Rouge, LA 70803 USA. [Smith, Jane M.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Chen, Q (reprint author), Louisiana State Univ, Dept Civil & Environm Engn, 3418 Patrick F Taylor Hall, Baton Rouge, LA 70803 USA. EM rjadha1@lsu.edu; qchen@lsu.edu; Jane.M.Smith@usace.army.mil FU US Department of Homeland Security (DHS) through the Southeast Region Research Initiative (SERRI); US National Science Foundation (NSF) [CBET-0652859, DMS-1115527] FX The study was supported by the US Department of Homeland Security (DHS) through the Southeast Region Research Initiative (SERRI) and by the US National Science Foundation (NSF) (Grant Nos. CBET-0652859 and DMS-1115527). We thank T. Baker Smith, LLC for the logistical support and topographic surveying, and the Louisiana Universities Marine Consortium (LUMCON) for providing meteorological data. Graduate students Kyle Parker, James Chatagnier and James Bouanchaud assisted in the field study. We also thank Dr. Weiming Wu of the University of Mississippi for helpful discussions. Any opinions, findings, conclusions and recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the NSF or the DHS. NR 38 TC 26 Z9 27 U1 2 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD JUL PY 2013 VL 77 BP 99 EP 107 DI 10.1016/j.coastaleng.2013.02.013 PG 9 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 135YA UT WOS:000318325400010 ER PT J AU Glonek, J AF Glonek, Joshua TI THE ECONOMIC EFFECT OF BANNING SMOKING IN WISCONSIN'S BARS AND RESTAURANTS SO CONTEMPORARY ECONOMIC POLICY LA English DT Article ID WORKERS AB There is much debate as to whether or not the passage of no-smoking laws has adverse consequences for businesses in the hospitality industry. In 2010, the state of Wisconsin implemented a law that banned smoking in all public places. Using a panel of county-level employment data, I examine the relationship between the implementation of smoking bans in Wisconsin and the subsequent changes in bar and restaurant employment. Using variation in the timing of bans that occurred as a result of four counties that implemented local bans prior to the July 2010 statewide ban, I conduct a difference-in-differences analysis to measure the average treatment effect of implementing a smoking ban in Wisconsin. I find that restaurant employment is not affected and that bar employment is significantly reduced as a result of the smoking ban. I also find that counties with higher levels of smoking prevalence see greater reductions in bar employment when a smoking ban is enacted. Back-of-the-envelope estimates suggest that even though there are employment losses, the benefits of the smoking ban outweigh the costs. (JEL L510, D780) C1 US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Glonek, J (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. EM joshua.gerald.glonek@us.army.mil NR 17 TC 0 Z9 0 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1074-3529 J9 CONTEMP ECON POLICY JI Contemp. Econ. Policy PD JUL PY 2013 VL 31 IS 3 BP 565 EP 579 DI 10.1111/coep.12003 PG 15 WC Economics; Public Administration SC Business & Economics; Public Administration GA 138KD UT WOS:000318506600008 ER PT J AU Kulkarni, SG Gao, XL Horner, SE Zheng, JQ David, NV AF Kulkarni, S. G. Gao, X. -L. Horner, S. E. Zheng, J. Q. David, N. V. TI Ballistic helmets - Their design, materials, and performance against traumatic brain injury SO COMPOSITE STRUCTURES LA English DT Review DE Helmet; Ballistic; Traumatic brain injury; Blast; Impact; Armor ID CENTRAL-NERVOUS-SYSTEM; MECHANICAL-PROPERTIES; CARBON NANOTUBES; COMPOSITE-MATERIALS; STRAIN RATES; BLAST-WAVE; TISSUE; IMPACT; MODEL; BEHAVIOR AB Protecting a soldier's head from injury is critical to function and survivability. Traditionally, combat helmets have been utilized to provide protection against shrapnel and ballistic threats, which have reduced head injuries and fatalities. However, home-made bombs or improvised explosive devices (IEDs) have been increasingly used in theatre of operations since the Iraq and Afghanistan conflicts. Traumatic brain injury (TB!), particularly blast-induced TB!, which is typically not accompanied by external body injuries, is becoming prevalent among injured soldiers. The responses of personal protective equipment, especially combat helmets, to blast events are relatively unknown. There is an urgent need to develop head protection systems with blast protection/mitigation capabilities in addition to ballistic protection. Modern military operations, ammunitions, and technology driven war tactics require a lightweight headgear that integrates protection mechanisms (against ballistics, blasts, heat, and noise), sensors, night vision devices, and laser range finders into a single system. The current article provides a comparative study on the design, materials, and ballistic and blast performance of the combat helmets used by the US Army based on a comprehensive and critical review of existing studies. Mechanisms of ballistic energy absorption, effects of helmet curvatures on ballistic performance, and performance measures of helmets are discussed. Properties of current helmet materials (including Kevlar (R) K29, K129 fibers and thermoset resins) and future candidate materials for helmets (such as nano-composites and thermoplastic polymers) are elaborated. Also, available experimental and computational studies on blast-induced TBI are examined, and constitutive models developed for brain tissues are reviewed. Finally, the effectiveness of current combat helmets against TBI is analyzed along with possible avenues for future research. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Kulkarni, S. G.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Gao, X. -L.] Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA. [Horner, S. E.; Zheng, J. Q.] USA, Program Execut Off SOLDIER, Ft Belvoir, VA 22060 USA. [David, N. V.] Univ Teknol MARA, Fac Mech Engn, Shah Alam 40450, Selangor, Malaysia. RP Gao, XL (reprint author), Univ Texas Dallas, Dept Mech Engn, 800 West Campbell Rd, Richardson, TX 75080 USA. EM Xin-Lin.Gao@utdallas.edu RI Arumugam, Thirumagal/C-3408-2014; N.V., David/B-1987-2010 OI N.V., David/0000-0003-4128-5850 FU US Army FX The work reported here is partially funded by the US Army. This support is gratefully acknowledged. The authors also thank Prof. Antonio Ferreira and two anonymous reviewers for their encouragement and helpful comments on an earlier version of the paper. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the US Army. NR 165 TC 27 Z9 28 U1 19 U2 178 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUL PY 2013 VL 101 BP 313 EP 331 DI 10.1016/j.compstruct.2013.02.014 PG 19 WC Materials Science, Composites SC Materials Science GA 133GR UT WOS:000318127400026 ER PT J AU Sankey, JB Wallace, CSA Ravi, S AF Sankey, Joel B. Wallace, Cynthia S. A. Ravi, Sujith TI Phenology-based, remote sensing of post-burn disturbance windows in rangelands SO ECOLOGICAL INDICATORS LA English DT Article DE Great Basin; Seeding; Sagebrush steppe; MODIS; AVHRR; Fourier; Harmonics; Erosion; Artemisia ID NDVI TIME-SERIES; MODIS-EVI DATA; FOURIER-ANALYSIS; VEGETATION RECOVERY; SOIL STABILITY; GREAT-BASIN; WILDFIRE; FIRE; USA; CLIMATE AB Wildland fire activity has increased in many parts of the world in recent decades. Ecological disturbance by fire can accelerate ecosystem degradation processes such as erosion due to combustion of vegetation that otherwise provides protective cover to the soil surface. This study employed a novel ecological indicator based on remote sensing of vegetation greenness dynamics (phenology) to estimate variability in the window of time between fire and the reemergence of green vegetation. The indicator was applied as a proxy for short-term, post-fire disturbance windows in rangelands: where a disturbance window is defined as the time required for an ecological or geomorphic process that is altered to return to pre-disturbance levels. We examined variability in the indicator determined for time series of MODIS and AVHRR NDVI remote sensing data for a database of similar to 100 historical wildland fires, with associated post-fire reseeding treatments, that burned 1990-2003 in cold desert shrub steppe of the Great Basin and Columbia Plateau of the western USA. The indicator-based estimates of disturbance window length were examined relative to the day of the year that fires burned and seeding treatments to consider effects of contemporary variability in fire regime and management activities in this environment. A key finding was that contemporary changes of increased length of the annual fire season could have indirect effects on ecosystem degradation, as early season fires appeared to result in longer time that soils remained relatively bare of the protective cover of vegetation after fires. Also important was that reemergence of vegetation did not occur more quickly after fire in sites treated with post-fire seeding, which is a strategy commonly employed to accelerate post-fire vegetation recovery and stabilize soil. Future work with the indicator could examine other ecological factors that are dynamic in space and time following disturbance - such as nutrient cycling, carbon storage, microbial community composition, or soil hydrology - as a function of disturbance windows, possibly using simulation modeling and historical wildfire information. Published by Elsevier Ltd. C1 [Sankey, Joel B.] US Geol Survey, Western Geog Sci Ctr, Flagstaff, AZ 86001 USA. [Sankey, Joel B.] USA, Natl Phenol Network, Flagstaff, AZ 86001 USA. [Wallace, Cynthia S. A.] US Geol Survey, Western Geog Sci Ctr, Tucson, AZ 85719 USA. [Ravi, Sujith] Stanford Univ, Stanford, CA 94305 USA. EM jsankey@usgs.gov RI Ravi, Sujith/C-3586-2008 OI Ravi, Sujith/0000-0002-0425-9373 FU U.S. Geological Survey Mendenhall Fellowship FX This research was supported by a U.S. Geological Survey Mendenhall Fellowship (Joel Sankey). The authors thank Matthew Bowker, David Pilliod, and David Pyke for providing helpful comments on this manuscript. Any use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 68 TC 5 Z9 5 U1 2 U2 62 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD JUL PY 2013 VL 30 BP 35 EP 44 DI 10.1016/j.ecolind.2013.02.004 PG 10 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 134EB UT WOS:000318191800006 ER PT J AU Rahman, M Hosur, M Zainuddin, S Vaidya, U Tauhid, A Kumar, A Trovillion, J Jeelani, S AF Rahman, Muhammad Hosur, Mahesh Zainuddin, Shaik Vaidya, Uday Tauhid, Arefin Kumar, Ashok Trovillion, Jonathan Jeelani, Shaik TI Effects of amino-functionalized MWCNTs on ballistic impact performance of E-glass/epoxy composites using a spherical projectile SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ballistic impact; Carbon nanotubes; Calendaring method; Damage area ID CARBON NANOTUBES; EPOXY COMPOSITES; PHYSICAL-PROPERTIES; NANOCOMPOSITES; DISPERSION; PERFORATION; PROTECTION; VOIDS AB Effect of adding amino-functionalized multi-walled carbon nanotubes (NH2-MWCNTs) on the ballistic performance of E-glass/epoxy composites was investigated in this study. E-glass/epoxy panels were prepared with and without MWCNTs. Two different weight percentages of 0.3 and 0.5% MWCNTs were used to modify the epoxy resin. MWCNTs were dispersed in epoxy resin through a combination of sonication and 3-roll mill methods. Laminated composite panels with E-glass plain weave fabrics were made through hand lay-up followed by compression molding process. Samples of size 120 x 120 x 5.25 mm were then cut from the panels and subjected to spherical projectile impacts using a gas-gun set-up at different velocities to determine the ballistic limit velocity (V-BL). Additionally, ballistic limit velocity was statistically determined through polynomial and power regression using experimental results. Ballistic limit increased by about 15-19 m/s (5-6.5%) for laminates with 0.3 wt.% MWCNTs. On the other hand, the performance of laminates with 0.5 wt.% MWCNTs was comparable with that of control samples. Damage size as determined by ultrasonic c-scan studies was considerably less for the laminates with MWCNTs at a given impact velocity below and above ballistic limit. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Rahman, Muhammad; Tauhid, Arefin; Jeelani, Shaik] Tuskegee Univ, Dept Mech Engn, Tuskegee, AL 36088 USA. [Hosur, Mahesh; Zainuddin, Shaik; Jeelani, Shaik] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. [Vaidya, Uday] Univ Alabama Birmingham, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. [Kumar, Ashok; Trovillion, Jonathan] USA, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Hosur, M (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. EM hosur@mytu.tuskegee.edu FU ERDC-CERL [W9132T-11-C-0027]; NSF-EPSCoR [EPS-1158862] FX Authors would like to acknowledge the support of ERDC-CERL (W9132T-11-C-0027) and NSF-EPSCoR (grant #EPS-1158862) for funding this work. NR 23 TC 9 Z9 9 U1 0 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUL PY 2013 VL 57 BP 108 EP 118 DI 10.1016/j.ijimpeng.2013.01.011 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 129ZM UT WOS:000317882500011 ER PT J AU Mathew, N Picu, CR Chung, PW AF Mathew, Nithin Picu, Catalin R. Chung, Peter. W. TI Peierls Stress of Dislocations in Molecular Crystal Cyclotrimethylene Trinitramine SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID INDEPENDENT SLIP SYSTEMS; PENTAERYTHRITOL TETRANITRATE; SINGLE-CRYSTALS; RDX; SIMULATIONS; DYNAMICS AB Dislocation mediated plasticity in the alpha phase of the energetic molecular crystal cyclotrimethylene trinitramine (RDX) was investigated using a combination of atomistic simulations and the Peierls-Nabarro (PN) model. A detailed investigation of core structures and dislocation Peierls stress was conducted using athermal atomistic simulations at atmospheric pressure to determine the active slip systems. Generalized stacking fault energy surfaces calculated using atomistic simulations were used in the PN model to also estimate the critical shear stress for dislocation motion. The primary slip plane is found to be (010) in agreement with experimental observations, with the (010)[100] slip systems having the lowest Peierls stress. In addition, atomistic simulations predict the (021)[0 (1) over bar2], (021)[100], (011)[100], (001)[100], and (001)[010] slip systems to have Peierls stress values small enough to allow plastic activity. However, there are less than five independent slip systems in this material in all situations. The ranking of slip systems based on the Peierls stress values is provided, and implications are discussed in relation to experimental data from nanoindentation and shock-induced plastic deformation. C1 [Mathew, Nithin; Picu, Catalin R.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. [Chung, Peter. W.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Picu, CR (reprint author), Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. RI Mathew, Nithin/L-9518-2015 OI Mathew, Nithin/0000-0002-2316-3190 FU Army Research Office [W911NF-09-1-0330] FX N.M. and R.C.P. gratefully acknowledge the support from the Army Research Office through Grant W911NF-09-1-0330, program director Dr. Joseph Myers. NR 29 TC 12 Z9 12 U1 0 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JUN 27 PY 2013 VL 117 IS 25 BP 5326 EP 5334 DI 10.1021/jp401368t PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 175NF UT WOS:000321236700012 PM 23734970 ER PT J AU Shukla, MK Hill, F AF Shukla, Manoj K. Hill, Frances TI Computational Investigation of Adsorption of 2,4,6-Trinitrotoluene on (0001) Surface of (4 x 4) alpha-Alumina SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID CRYSTAL ALPHA-AL2O3(0001) SURFACE; 1ST PRINCIPLES; DENSITY; AL2O3; WATER; H2O AB Adsorption of 2,4,6-trinitrotoluene (TNT) on a (0001) surface of (4 x 4) Al-terminated alpha-Al2O3 was investigated at the plane-wave density functional theory (DFT) level utilizing the PBE variant of the generalized-gradient approximation. Interactions of valence electrons with atomic cores were treated by ultrasoft pseudopotentials. Both the perpendicular and parallel orientations of TNT with respect to the substrate surface were considered. It was revealed that TNT is adsorbed strongly on the alumina surface. Such adsorption is characterized by the coordination of surface aluminum ions with nitro groups of TNT. In the perpendicular orientation of TNT, only a single nitro group is involved in the interaction with the surface while all nitro groups are involved in interaction with alumina surface in the parallel orientation resulting in much stronger binding than the perpendicular orientation. Further, a methyl hydrogen atom was also found to be involved in weak interactions with nearby oxygen atoms of the second layer. Thus, a parallel orientation of TNT will be more favorable for adsorption on the Al-terminated alpha-Al2O3 (0001) surface. Consequent to adsorption, the positions of coordinated Al ions are significantly distorted (pulled up toward TNT) as compared to the plane containing the rest of the Al atoms. Moreover, the buildup of electronic charge in the nitro oxygen-surface Al bonding region indicated the covalent nature of the TNT adsorption on the Al-terminated (0001) surface of alpha-alumina. C1 [Shukla, Manoj K.; Hill, Frances] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil NR 32 TC 3 Z9 3 U1 2 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUN 27 PY 2013 VL 117 IS 25 BP 13136 EP 13142 DI 10.1021/jp403499p PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 175NC UT WOS:000321236400026 ER PT J AU Lon, C Timmermans, A Buathong, N Nou, S Se, Y Sitthy, N Chann, S Kraesub, S Wongstitwilairoong, T Walsh, DS Tyner, S Fukuda, M Callender, D Sherwood, J Koy, L Char, M Bethell, D Saunders, D AF Lon, Chanthap Timmermans, Ans Buathong, Nillawan Nou, Samon Se, Youry Sitthy, Ngo Chann, Soklyda Kraesub, Somporn Wongstitwilairoong, Tippa Walsh, Douglas S. Tyner, Stuart Fukuda, Mark Callender, David Sherwood, Jeffrey Koy, Lenin Char, Mengchour Bethell, Delia Saunders, David TI Severe malaria in Battambang Referral Hospital, an area of multidrug resistance in Western-Cambodia: a retrospective analysis of cases from 2006-2009 SO MALARIA JOURNAL LA English DT Article ID SEVERE FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; KENYAN CHILDREN; ARTESUNATE; BACTEREMIA; ADULTS; QUININE; TRIAL; AGE AB Background: Despite recent malaria containment and control efforts leading to reduced incidence, Cambodia remains endemic for both Plasmodium vivax and multidrug-resistant Plasmodium falciparum malaria. Little has been reported in the peer-reviewed literature regarding the burden of severe malaria (SM) in Cambodia. Methods: Medical records for all patients admitted to the Battambang Referral Hospital (BRH) with an admitting or discharge diagnosis of SM from 2006 to 2009 (suspected SM cases) were reviewed. Those meeting the case definition of SM according to retrospective chart review and investigator assessment of probable cases, based on published national guidelines available at the time, were analysed for trends in demographics, mortality and referral patterns. Results: Of the 537 suspected SM cases at BRH during the study period, 393 (73%) met published WHO criteria for SM infection. Despite limited diagnostic and treatment facilities, overall mortality was 14%, with 7% mortality in children 14 and under, but 19% in adults (60% of cases). Cerebral malaria with coma was relatively rare (17%), but mortality was disproportionately high at 35%. Mean time to hospital presentation was five days (range one to 30 days) after onset of symptoms. While patients with delays in presentation had worse outcomes, there was no excess mortality based on treatment referral times, distance travelled or residence in artemisinin-resistance containment (ARC) Zone 1 compared to Zone 2. Conclusions: Despite limitations in diagnosis and treatment, and multiple confounding co-morbidities, mortality rates at BRH were similar to reports from other countries in the region. Interventions to improve access to early diagnosis and effective treatment, combined with modest improvements in intensive care, are likely to reduce mortality further. Patients referred from Zone 1 did not have excess mortality compared to Zone 2 ARC areas. A steep decrease in SM cases and deaths observed in the first half of 2009 has since continued, indicating some success from containment efforts despite the emergence of artemisinin resistance in this area. C1 [Lon, Chanthap; Timmermans, Ans; Buathong, Nillawan; Se, Youry; Kraesub, Somporn; Wongstitwilairoong, Tippa; Walsh, Douglas S.; Tyner, Stuart; Bethell, Delia; Saunders, David] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Nou, Samon; Chann, Soklyda] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Sitthy, Ngo; Koy, Lenin] Battambang Referral Hosp, Battambang Dist, Battambang Prov, Cambodia. [Fukuda, Mark] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Callender, David] Tripler Army Med Ctr, Honolulu, HI USA. [Sherwood, Jeffrey] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Char, Mengchour] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Lon, C (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM chanthapl@afrims.org FU Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center) FX The authors thank the CNM and Director and staff of Battambang Referral Hospital, and the Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center) for financial support of this work. We are grateful to the patients included in this study and hope that the knowledge gained will contribute to a continuing decrease of severe malaria in Cambodia. NR 29 TC 4 Z9 4 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 27 PY 2013 VL 12 AR 217 DI 10.1186/1475-2875-12-217 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 174ES UT WOS:000321137500001 PM 23802651 ER PT J AU Yuill, B Roig-Silva, C Walshire, L AF Yuill, Brendan Roig-Silva, Carla Walshire, Lucas TI Application of an alluvial architecture model to better understand seepage risk in floodplains SO ENGINEERING GEOLOGY LA English DT Article DE Geomorphology; Alluvial architecture; Floodplains; Groundwater seepage; Landscape evolution modeling; Risk assessment ID FLUVIAL CHANNEL; COMPENSATIONAL STACKING; SEDIMENTARY DEPOSITS; AVULSION FREQUENCY; MISSISSIPPI VALLEY; SIMULATION-MODEL; RIVER AVULSION; SAND BODIES; DIMENSIONS; COLORADO AB The amount and distribution of coarse-grained sediment (e.g., sands and gravels) relative to fine-grained sediment (e.g., clays and silts) within a floodplain influences many of the floodplain geotechnical properties, including the potential for groundwater seepage. Seepage is a primary driver of levee and dam failure, and understanding its potential is of paramount concern to engineers and resource managers. This paper reports the results of a computational modeling study that simulated alluvial floodplain construction using a suite of simple geomorphic process-imitating rules. A model aggrades a floodplain cross section within an alluvial basin, creating floodplain architecture by differentiating between sediment deposited by channel processes (sand) and sediment deposited by overbank flood processes (clay). The evolution of two floodplain cross sections of the Trinity River, near Dallas, Texas is simulated using five different experimental scenarios. The study area is the site of large levee rehabilitation projects in which accurate characterization of the geologic environment has significant engineering importance. Study results predict that scenario components including the alluvial basin width, the initial topography of the floodplain base level, and the channel aggradation rate significantly affect the fraction of the floodplain width that contains channel deposits by influencing the avulsion frequency of the river during floodplain construction. Increased avulsion frequency equated to more numerous, yet smaller channel deposits. The dimensions of the channel deposits predicted by this study are similar to those typically observed in large, fully meandering river systems. The model devised for this study is relatively simple and can be run in multiple iterations to produce probabilistic outputs, such as the likely range of channel deposit widths within a floodplain cross section. This type of information is useful to engineers for a host of applications including predicting the data collection density necessary to characterize the geotechnical properties of a project site. (C) 2013 Published by Elsevier B.V. C1 [Yuill, Brendan] USACE Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Roig-Silva, Carla; Walshire, Lucas] USACE Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Yuill, B (reprint author), USACE Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM brendan.tyuill@usace.army.mil NR 59 TC 1 Z9 1 U1 0 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD JUN 27 PY 2013 VL 160 BP 110 EP 124 DI 10.1016/j.enggeo.2013.04.003 PG 15 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 163RB UT WOS:000320353500011 ER PT J AU Hutchison, N Leberg, PL Lance, RF AF Hutchison, Nichole Leberg, Paul. L. Lance, Richard F. TI Development of novel microsatellite markers for the secret cave cricket, Ceuthophilus secretus SO JOURNAL OF INSECT SCIENCE LA English DT Article DE codominant markers; population genetics; simple sequence repeat DNA; trogloxenes ID NULL ALLELES; RHAPHIDOPHORIDAE; ORTHOPTERA; SOFTWARE AB The secret cave cricket, Ceuthophilus secretus Scudder (Orthroptera: Rhaphidophoridae), is an obligate trogloxene endemic to central Texas, USA, and is a primary source of energy and nutrients for sensitive cave ecosystems. In this study, nine polymorphic microsatellite markers were developed from genomic DNA of C. secretus. Genotypes of 120 individuals sampled from four localities on the Fort Hood Military Reservation, Killeen, Texas, were analyzed to characterize the polymorphism at each locus. The number of alleles ranged from 19 to 46. All paired loci were in linkage equilibrium. Four loci had significant deviations from Hardy-Weinberg equilibrium. Observed heterozygosity varied from 0.793 to 0.959. These loci provide a means of characterizing population genetic structure in this species. C1 [Hutchison, Nichole; Leberg, Paul. L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. [Lance, Richard F.] USA, Engn Res & Dev Ctr, Environm Lab, Environm Proc Branch, Vicksburg, MS 39180 USA. RP Leberg, PL (reprint author), Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. EM nhutch227@gmail.com; leberg@louisiana.edu; richard.f.lance@usace.army.mil FU Research, Development, Test and Evaluation (6.1) Basic Research Program in Environmental Quality FX Special thanks are extended to W. C. Larsen, J. K. Krejca, and Zara Environmental LLC, as well as C. E. Pekins and the Fort Hood Natural Resources Branch, for their assistance in specimen collection. Thanks are also extended to M. R. Carr for assistance with manuscript preparation. This research was funded by the Research, Development, Test and Evaluation (6.1) Basic Research Program in Environmental Quality, as administered by the U.S. Army Engineer Research & Development Center. NR 17 TC 1 Z9 1 U1 1 U2 8 PU UNIV ARIZONA PI TUCSON PA LIBRARY C327, TUCSON, AZ 85721 USA SN 1536-2442 J9 J INSECT SCI JI J Insect Sci. PD JUN 25 PY 2013 VL 13 AR 64 PG 6 WC Entomology SC Entomology GA 172WC UT WOS:000321035000004 PM 23909682 ER PT J AU Marcsisin, SR Jin, XN Bettger, T McCulley, N Sousa, JC Shanks, GD Tekwani, BL Sahu, R Reichard, GA Sciotti, RJ Melendez, V Pybus, BS AF Marcsisin, Sean R. Jin, Xiannu Bettger, Theresa McCulley, Nicholas Sousa, Jason C. Shanks, G. Dennis Tekwani, Babu L. Sahu, Rajnish Reichard, Gregory A. Sciotti, Richard J. Melendez, Victor Pybus, Brandon S. TI CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever SO MALARIA JOURNAL LA English DT Article DE Quinine; Blackwater fever; Metabolism; CYP450; Metabolite identification ID AUTOIMMUNE HEMOLYTIC-ANEMIA; HUMAN LIVER-MICROSOMES; ARTEMISININ DERIVATIVES; SEVERE MALARIA; RIFAMPICIN; CHILDREN; URINE AB Background: The naturally occurring alkaloid drug, quinine is commonly used for the treatment of severe malaria. Despite centuries of use, its metabolism is still not fully understood, and may play a role in the haemolytic disorders associated with the drug. Methods: Incubations of quinine with CYPs 1A2, 2C9, 2C19, 2D6, and 3A4 were conducted, and the metabolites were characterized by accurate mass UPLC-MSE analysis. Reactive oxygen species generation was also measured in human erythrocytes incubated in the presence of quinine with and without microsomes. Results: The metabolites 3-hydroxyquinine, 2'-oxoquininone, and O-desmethylquinine were observed after incubation with CYPs 3A4 (3-hydroxyquinine and 2'-oxoquininone) and 2D6 (O-desmethylquinine). In addition, multiple hydroxylations were observed both on the quinoline core and the quinuclidine ring system. Of the five primary abundance CYPs tested, 3A4, 2D6, 2C9, and 2C19 all demonstrated activity toward quinine, while 1A2 did not. Further, quinine produced robust dose-dependent oxidative stress in human erythrocytes in the presence of microsomes. Conclusions: Taken in context, these data suggest a CYP-mediated link between quinine metabolism and the poorly understood haemolytic condition known as blackwater fever, often associated with quinine ingestion. C1 [Marcsisin, Sean R.; Jin, Xiannu; Bettger, Theresa; McCulley, Nicholas; Sousa, Jason C.; Reichard, Gregory A.; Sciotti, Richard J.; Melendez, Victor; Pybus, Brandon S.] Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Shanks, G. Dennis] Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. [Tekwani, Babu L.; Sahu, Rajnish] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA. RP Pybus, BS (reprint author), Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM brandon.s.pybus.mil@mail.mil RI Sousa, Jason/A-9177-2011; Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 24 TC 5 Z9 5 U1 2 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 21 PY 2013 VL 12 AR 214 DI 10.1186/1475-2875-12-214 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 171QO UT WOS:000320944300001 PM 23800033 ER PT J AU Pybus, BS Marcsisin, SR Jin, XN Deye, G Sousa, JC Li, QG Caridha, D Zeng, Q Reichard, GA Ockenhouse, C Bennett, J Walker, LA Ohrt, C Melendez, V AF Pybus, Brandon S. Marcsisin, Sean R. Jin, Xiannu Deye, Gregory Sousa, Jason C. Li, Qigui Caridha, Diana Zeng, Qiang Reichard, Gregory A. Ockenhouse, Christian Bennett, Jason Walker, Larry A. Ohrt, Colin Melendez, Victor TI The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 SO MALARIA JOURNAL LA English DT Article ID INDUCED HEMOLYTIC-ANEMIA; ANTIMALARIAL-DRUG PRIMAQUINE; CYTOCHROME-P450 2D6; RAT ERYTHROCYTES; 6-METHOXY-8-HYDROXYLAMINOQUINOLINE; 8-AMINOQUINOLINES AB Background: The efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been historically linked to CYP-mediated metabolism. Although to date no clear evidence exists in the literature that unambiguously assigns the metabolic pathway or specific metabolites necessary for activity, recent literature suggests a role for CYP 2D6 in the generation of redox active metabolites. Methods: In the present study, the specific CYP 2D6 inhibitor paroxetine was used to assess its effects on the production of specific phenolic metabolites thought to be involved in PQ efficacy. Further, PQ causal prophylactic (developing liver stage) efficacy against Plasmodium berghei in CYP 2D knockout mice was assessed in comparison with a normal C57 background and with humanized CYP 2D6 mice to determine the direct effects of CYP 2D6 metabolism on PQ activity. Results: PQ exhibited no activity at 20 or 40 mg/kg in CYP 2D knockout mice, compared to 5/5 cures in normal mice at 20 mg/kg. The activity against developing liver stages was partially restored in humanized CYP 2D6 mice. Conclusions: These results unambiguously demonstrate that metabolism of PQ by CYP 2D6 is essential for antimalarial causal prophylaxis efficacy. C1 [Pybus, Brandon S.; Marcsisin, Sean R.; Jin, Xiannu; Deye, Gregory; Sousa, Jason C.; Li, Qigui; Caridha, Diana; Zeng, Qiang; Reichard, Gregory A.; Ockenhouse, Christian; Bennett, Jason; Ohrt, Colin; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Walker, Larry A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA. RP Pybus, BS (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM brandon.pybus@us.army.mil RI Sousa, Jason/A-9177-2011 NR 23 TC 38 Z9 38 U1 0 U2 20 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 20 PY 2013 VL 12 AR 212 DI 10.1186/1475-2875-12-212 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 168QB UT WOS:000320719500001 PM 23782898 ER PT J AU Dong, H Snyder, JF Tran, DT Leadore, JL AF Dong, Hong Snyder, James F. Tran, Dat T. Leadore, Julia L. TI Hydrogel, aerogel and film of cellulose nanofibrils functionalized with silver nanoparticles SO CARBOHYDRATE POLYMERS LA English DT Article DE Nanocellulose; Nanofibrillated cellulose; Silver nanoparticles; Hydrogel; Aerogel; Nanocellulose film ID TEMPO-MEDIATED OXIDATION; NATIVE CELLULOSE; NANOPAPER STRUCTURES; METAL NANOPARTICLES; NANOCRYSTAL AB In this work, we describe hydrogels, aerogels and films of nanofibrillated cellulose (NFC) functionalized with metal nanoparticles using silver as an example. The TEMPO process used to produce NFC generates negatively charged surface carboxylate groups that provide high binding capability to transition metal species such as Ag+. The gelation of NFC triggered by transition monovalent metal ions was revealed for the first time. The interaction was utilized to bind Ag+ on the NFC surface and simultaneously induce formation of NFC-Ag+ hydrogels, where Ag+ was slowly reduced to Ag nanoparticles by hydroxyl groups on NFC without additional reducing agent. The NFC-Ag+ hydrogel was initiated by strong association of carboxylate groups on NFC with Ag+ and sufficient NFC surface charge reduction. The stiff hydrogel has a storage modulus leveled off at a plateau value of similar to 6800 Pa. Porous aerogels and flat thin films comprising a continuous matrix of NFC were decorated with Ag nanoparticles through freeze-drying or solution-casting of NFC-Ag+ dispersions with low contents of Ag+, respectively, followed by UV reduction. The presence of Ag species on NFC reduced coalescence of nanofibrils in the film formation as revealed from AFM phase images. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Dong, Hong; Snyder, James F.; Leadore, Julia L.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Tran, Dat T.] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Dong, H (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM hong.dong.ctr@mail.mil FU Oak Ridge Institute for Science and Education FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The authors thank Dr. Alan Rudie and Mr. Richard Reiner in USDA Forest Product Laboratory for supplying the nanocellulose dispersion, as well as Dr. Lars Piehler, Dr. Josh Orlicki and Dr. Kenneth Strawhecker at USARL for many useful discussions. NR 29 TC 33 Z9 34 U1 19 U2 297 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8617 EI 1879-1344 J9 CARBOHYD POLYM JI Carbohydr. Polym. PD JUN 20 PY 2013 VL 95 IS 2 BP 760 EP 767 DI 10.1016/j.carbpol.2013.03.041 PG 8 WC Chemistry, Applied; Chemistry, Organic; Polymer Science SC Chemistry; Polymer Science GA 154AW UT WOS:000319644900020 PM 23648039 ER PT J AU Hobbs, CV De La Vega, P Penzak, SR Van Vliet, J Krzych, U Sinnis, P Borkowsky, W Duffy, PE AF Hobbs, Charlotte V. De La Vega, Patricia Penzak, Scott R. Van Vliet, Jillian Krzych, Urszula Sinnis, Photini Borkowsky, William Duffy, Patrick E. TI The effect of antiretrovirals on Plasmodium falciparum liver stages SO AIDS LA English DT Article ID TYPE-1 PROTEASE INHIBITORS; HUMAN HEPATOCYTE LINE; MALARIA PARASITES; IN-VITRO; SPOROZOITES; AGENTS C1 [Hobbs, Charlotte V.; Van Vliet, Jillian; Duffy, Patrick E.] NIAID, NIH, Lab Malaria Immunol & Vaccinol, Rockville, MD 20852 USA. [De La Vega, Patricia; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Dept Cellular Immunol, Silver Spring, MD USA. [Penzak, Scott R.] NIH, Dept Pharm, Ctr Clin, Clin Pharmacokinet Res Lab, Bethesda, MD 20892 USA. [Sinnis, Photini] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Borkowsky, William] NYU, Sch Med, Dept Pediat, Div Infect Dis & Immunol, New York, NY USA. RP Hobbs, CV (reprint author), NIAID, NIH, Rockville, MD 20852 USA. EM charlotte.hobbs@nih.gov FU NIH, NIAID, Division of Intramural Research; US Army and Materiel Command FX This work was funded by the NIH, NIAID, Division of Intramural Research and by the by the US Army and Materiel Command. NR 21 TC 8 Z9 8 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JUN 19 PY 2013 VL 27 IS 10 BP 1674 EP 1677 DI 10.1097/QAD.0b013e3283621dd4 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 250HG UT WOS:000326840700017 PM 23907270 ER PT J AU Taylor, WRJ Widjaja, H Basri, H Tjitra, E Ohrt, C Taufik, T Baso, S Hoffman, SL Richie, TL AF Taylor, Walter R. J. Widjaja, Hendra Basri, Hasan Tjitra, Emiliana Ohrt, Colin Taufik, Taufik Baso, Samuel Hoffman, Stephen L. Richie, Thomas L. TI Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria SO MALARIA JOURNAL LA English DT Article DE Anaemia; Malaria; Papuans; Indonesia ID TUMOR-NECROSIS-FACTOR; BONE-MARROW CHANGES; RED-BLOOD-CELLS; PLASMODIUM-FALCIPARUM; IN-VIVO; WESTERN KENYA; FACTOR-ALPHA; ANEMIA; CHILDREN; ERYTHROPOIETIN AB Background: Haemoglobin (Hb) recovers slowly in malaria and may be influenced by naturally acquired immunity. Hb recovery was compared in malaria immune, indigenous Papuan and non-Papuan adults with limited malaria exposure. Methods: Hb concentrations were measured on Days (D) 0, 3, 7, and 28 in 57 Papuans and 105 non-Papuans treated with chloroquine, doxycycline or both drugs for acute, uncomplicated Plasmodium vivax (n = 64) or Plasmodium falciparum (n = 98). Results: Mean (SD, range) D0 Hb was 12.7 (2.2, 7-21.3) g/dL and was similar in P. falciparum infected Papuans and non-Papuans: 12.2 vs. 12.8 g/dL (P = 0.15) but significantly lower in: (i) P. vivax-infected Papuans vs. P. vivax-infected non-Papuans: 11.4 vs. 13.47 g/dL [Delta = -2.07 (95% CI: -3.3 - -0.8), P = 0.0018], (ii) all patients with splenomegaly (vs. those without splenomegaly): 12.16 vs. 13.01 g/dL [Delta = -0.85 (-1.6- -0.085), P = 0.029], and (iii) all females vs. all males: 10.18 vs. 13.01 g/dL [Delta = -2.82 (-3.97 - -1.67), P < 0.0001]. Multiple regression identified female sex (P = 0.000), longer illness duration (P = 0.015) (P. falciparum patients) and Papuan ethnicity (P = 0.017) (P. vivax patients) as significant factors for a lower D0 Hb. Mean D28 Hb increased to 13.6 g/dL [Delta = 1.01 (0.5-1.5) vs. D0 Hb, P = 0.0001]. It was: (i) positively correlated with the D0 Hb (adjusted R-2 = 0.24, P = 0.000), and was significantly lower in P. vivax infected Papuans vs. non-Papuans: 12.71 vs. 14.46 g/dL [Delta = -1.7 (-2.95- -0.5, P = 0.006). Conclusions: Haemoglobin recovery was related to baseline Hb. Vivax-infected malaria immune Papuans had persistently lower Hb concentrations compared to non-Papuans with limited malaria exposure. This haematological disadvantage remains unexplained. C1 [Taylor, Walter R. J.; Widjaja, Hendra; Basri, Hasan; Richie, Thomas L.] US Navy Med Res Unit 2 NAMRU 2, Jakarta, Indonesia. [Taylor, Walter R. J.] Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70118 USA. [Tjitra, Emiliana] Natl Inst Hlth, Ctr Hlth Res & Dev, Jakarta, Indonesia. [Ohrt, Colin] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Taufik, Taufik] Indonesian Naval Hosp, Jayapura, Papua, Indonesia. [Baso, Samuel] Rumah Sakit Umum, Jayapura, Papua, Indonesia. [Hoffman, Stephen L.] USN, Med Res Ctr, Bethesda, MD 20084 USA. RP Taylor, WRJ (reprint author), US Navy Med Res Unit 2 NAMRU 2, Jakarta, Indonesia. EM bob@tropmedres.ac OI Richie, Thomas/0000-0002-2946-5456 FU US Naval Medical Research and Development Command [DoD 63002A M00101 HEX 2406] FX This study was funded by the US Naval Medical Research and Development Command (DoD 63002A M00101 HEX 2406). NR 39 TC 5 Z9 5 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 19 PY 2013 VL 12 AR 209 DI 10.1186/1475-2875-12-209 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 168QA UT WOS:000320719400001 PM 23777546 ER PT J AU Kuschner, RA Russell, KL Abuja, M Bauer, KM Faix, DJ Hait, H Henrick, J Jacobs, M Liss, A Lynch, JA Liu, Q Lyons, AG Malik, M Moon, JE Stubbs, J Sun, W Tang, D Towle, AC Walsh, DS Wilkerson, D AF Kuschner, Robert A. Russell, Kevin L. Abuja, Mary Bauer, Kristen M. Faix, Dennis J. Hait, Howard Henrick, Jennifer Jacobs, Michael Liss, Alan Lynch, Julia A. Liu, Qi Lyons, Arthur G. Malik, Mohammad Moon, James E. Stubbs, Jeremiah Sun, Wellington Tang, Doug Towle, Andrew C. Walsh, Douglas S. Wilkerson, Deborah CA Adenovirus Vaccine Efficacy Trial TI A phase 3, randomized, double-blind, placebo-controlled study of the safety and efficacy of the live, oral adenovirus type 4 and type 7 vaccine, in US military recruits SO VACCINE LA English DT Article DE Adenovirus Type 4 and Type 7 vaccine, live, oral; Adenovirus Type 4; ADV-4; Adenovirus Type 7; ADV-7; Oral vaccine; Live vaccines; Acute respiratory infection ID ACUTE RESPIRATORY-DISEASE; DIPLOID TISSUE CULTURE; SELECTIVE INFECTION; RELATIVE RISK; SAMPLE-SIZE; IMMUNIZATION; EMERGENCE; POTENCY AB Adenovirus (ADV) types 4 (ADV-4) and 7 (ADV-7) are presently the major cause of febrile acute respiratory disease (ARD) in U.S. military recruits. We conducted a multi-center, randomized, double-blind, placebo-controlled phase 3 study of the new vaccine to assess its safety and efficacy. Healthy adults at two basic training sites were randomly assigned to receive either vaccine (two enteric-coated tablets consisting of no less than 4.5 log(10) TCID50 of live ADV-4 or ADV-7) or placebo in a 3:1 ratio. Volunteers were observed throughout the approximate eight weeks of their basic training and also returned for four scheduled visits. The primary endpoints were prevention of febrile ARD due to ADV-4 and seroconversion of neutralizing serum antibodies to ADV-7, which was not expected to circulate in the study population during the course of the trial. A total of 4151 volunteers were enrolled and 4040 (97%) were randomized and included in the primary analysis (110 were removed prior to randomization and one was removed after randomization due to inability to swallow tablets). A total of 49 ADV-4 febrile ARD cases were identified with 48 in the placebo group and 1 in the vaccine group (attack rates of 4.76% and 0.03%, respectively). Vaccine efficacy was 99.3% (95% CI, 96.0-99.9; P<0.001). Seroconversion rates for vaccine recipients for ADV-4 and ADV-7 were 94.5% (95% Cl, 93.4-95.5%) and 93.8% (95% CI: 93.4-95.2%), respectively. The vaccine was well tolerated as compared to placebo. We conclude that the new live, oral ADV-4 and ADV-7 vaccine is safe and effective for use in groups represented by the study population. Published by Elsevier Ltd. C1 [Kuschner, Robert A.; Bauer, Kristen M.; Lynch, Julia A.; Lyons, Arthur G.; Moon, James E.; Stubbs, Jeremiah; Sun, Wellington; Tang, Doug; Walsh, Douglas S.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Russell, Kevin L.; Abuja, Mary; Faix, Dennis J.] Naval Hlth Res Ctr, San Diego, CA USA. [Hait, Howard; Henrick, Jennifer; Liss, Alan; Wilkerson, Deborah] Barr Labs Inc, Pomona, NY USA. [Jacobs, Michael; Malik, Mohammad] Captain James A Lovell Fed Hlth Care Ctr, N Chicago, IL USA. [Liu, Qi] Barr Labs, Newtown, PA USA. [Towle, Andrew C.] VaccGen Int LLC, Larchmont, NY USA. RP Kuschner, RA (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robert.a.kuschner.mil@mail.mil; Kevin.russell4@us.army.mil; mary.abuja@med.navy.mil; Kristen.Bauer@afrims.org; dennis.faix@med.navy.mil; howardhait@edenridgeassociates.com; jennifer.henrick@tevapharm.com; michael.jacobs@med.navy.mil; alan.liss@fda.hhs.gov; Julia.lynch@us.army.mil; Qi.liu@msn.com; Arthur.lyons@us.army.mil; Mohammad.malik@va.gov; james.e.moon@us.army.mil; jeremiah.stubbs@us.army.mil; wellington.sun@fda.hhs.gov; dtang38@verizon.net; andy_t1@msn.com; douglas.walsh@afrims.org; debbie.s.wilkerson@medtronic.com RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 FU DoD [DAMD17-01-C-0058] FX The opinions expressed herein are the private views of the authors and are not to be construed as official viewpoints of the U.S. Departments of State, Army, Navy or Defense. This study was funded (in part) by DoD Contract DAMD17-01-C-0058 to Barr Laboratories. NR 24 TC 15 Z9 16 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 19 PY 2013 VL 31 IS 28 BP 2963 EP 2971 DI 10.1016/j.vaccine.2013.04.035 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 175KW UT WOS:000321230600008 PM 23623865 ER PT J AU Johansen, LM Brannan, JM Delos, SE Shoemaker, CJ Stossel, A Lear, C Hoffstrom, BG DeWald, LE Schornberg, KL Scully, C Lehar, J Hensley, LE White, JM Olinger, GG AF Johansen, Lisa M. Brannan, Jennifer M. Delos, Sue E. Shoemaker, Charles J. Stossel, Andrea Lear, Calli Hoffstrom, Benjamin G. DeWald, Lisa Evans Schornberg, Kathryn L. Scully, Corinne Lehar, Joseph Hensley, Lisa E. White, Judith M. Olinger, Gene G. TI FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID NIEMANN-PICK C1; HEMORRHAGIC FEVERS; ENDOTHELIAL-CELLS; FILOVIRUS ENTRY; MOUSE MODEL; HOST-CELL; IN-VIVO; GLYCOPROTEIN; FUSION; BINDING AB Ebola viruses remain a substantial threat to both civilian and military populations as bioweapons, during sporadic outbreaks, and from the possibility of accidental importation from endemic regions by infected individuals. Currently, no approved therapeutics exist to treat or prevent infection by Ebola viruses. Therefore, we performed an in vitro screen of Food and Drug Administration (FDA)- and ex-US-approved drugs and selected molecular probes to identify drugs with antiviral activity against the type species Zaire ebolavirus (EBOV). From this screen, we identified a set of selective estrogen receptor modulators (SERMs), including clomiphene and toremifene, which act as potent inhibitors of EBOV infection. Anti-EBOV activity was confirmed for both of these SERMs in an in vivo mouse infection model. This anti-EBOV activity occurred even in the absence of detectable estrogen receptor expression, and both SERMs inhibited virus entry after internalization, suggesting that clomiphene and toremifene are not working through classical pathways associated with the estrogen receptor. Instead, the response appeared to be an off-target effect where the compounds interfere with a step late in viral entry and likely affect the triggering of fusion. These data support the screening of readily available approved drugs to identify therapeutics for the Ebola viruses and other infectious diseases. The SERM compounds described in this report are an immediately actionable class of approved drugs that can be repurposed for treatment of filovirus infections. C1 [Johansen, Lisa M.; Hoffstrom, Benjamin G.; Lehar, Joseph] Zalicus Inc, Cambridge, MA 02142 USA. [Brannan, Jennifer M.; Stossel, Andrea; Lear, Calli; DeWald, Lisa Evans; Scully, Corinne; Hensley, Lisa E.; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Frederick, MD 21701 USA. [Delos, Sue E.; Shoemaker, Charles J.; Schornberg, Kathryn L.; White, Judith M.] Univ Virginia, Charlottesville, VA 22908 USA. RP Johansen, LM (reprint author), Zalicus Inc, 245 1st St, Cambridge, MA 02142 USA. EM ljohansen@zalicus.com; gene.olinger@us.army.mil OI Olinger, Gene/0000-0001-7338-0292 FU DTRA [4.10007_08_RD_B]; USAMRIID [W81XWH-08-0051]; NIH [U54 AI057168]; National Research Council Research Associateship Awards at USAMRIID FX This work was funded by DTRA project 4.10007_08_RD_B awarded to G.G.O. and subcontract (W81XWH-08-0051) awarded to L.M.J. from USAMRIID, as well as by NIH grant U54 AI057168 awarded to J.M.W. This research was performed while J.M.B. and L. E. D. held National Research Council Research Associateship Awards at USAMRIID. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 44 TC 65 Z9 71 U1 1 U2 37 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 J9 SCI TRANSL MED JI Sci. Transl. Med. PD JUN 19 PY 2013 VL 5 IS 190 AR 190ra79 DI 10.1126/scitranslmed.3005471 PG 13 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 167UN UT WOS:000320660700004 PM 23785035 ER PT J AU Stratman, KN Wilson, PC Overholt, WA Cuda, JP Netherland, MD AF Stratman, Karen N. Wilson, P. Chris Overholt, William A. Cuda, James P. Netherland, Michael D. TI Toxicity of Fipronil to the Midge, Cricotopus lebetis Sublette SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID DESULFINYL PHOTOPRODUCT; INSECTICIDES; STREAMS; PYRETHROIDS; SEDIMENTS AB Fipronil, a relatively new insecticide more recently developed than organophosphates and pyrethroids, has been detected in surface water draining from agricultural and urban-developed areas. This insecticide is primarily lost through subsurface and surface drainage from terrestrial areas where it has been applied. Invasive aquatic plants often need to be managed in these receiving water bodies to prevent loss of recreational and functional values (e.g., drainage), especially in subtropical and tropical areas. One insect of particular interest is the chironomid midge Cricotopus lebetis Sublette, which may be a useful augmentative biocontrol agent for the invasive aquatic weed Hydrilla verticillata L.f. Royale. Exposure of aquatic organisms, especially insects, to fipronil may significantly impact nontarget populations. These studies investigated the sensitivity of C. lebetis to fipronil exposures ranging from 24 to 96 h. The LC50 observed for each exposure interval was 7.26 g/L (24 h), 2.61 g/L (48 h), 1.78 g/L (72 h), and 1.06 g/L (96 h). The LC90 values observed were 47.18 g/L (24 h), 9.55 g/L (48 h), 6.45 g/L (72 h), and 4.81 g/L (96 h). Behavioral changes were seen at all fipronil concentration levels, where larvae exited the plant and exhibited abnormal behavior, such as restricted movement and lack of feeding. Results indicate that acute lethality occurred at environmentally relevant concentrations of fipronil. C1 [Stratman, Karen N.; Overholt, William A.] Univ Florida, Indian River Res & Educ Ctr, Dept Entomol, Ft Pierce, FL USA. [Wilson, P. Chris] Univ Florida, Indian River Res & Educ Ctr, Soil & Water Sci Dept, Ft Pierce, FL USA. [Cuda, James P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Netherland, Michael D.] US Army Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL USA. RP Wilson, PC (reprint author), Univ Florida, IFAS, IRREC, 2199 South Rock Rd, Ft Pierce, FL 34945 USA. EM pcwilson@ufl.edu FU USDA/NIFA/RAMP [2010-02825]; Florida Fish and Wildlife Conservation Commission FX We thank the USDA/NIFA/RAMP grant 2010-02825 (Sustainable Approach for Integrated Management of Hydrilla) and the Florida Fish and Wildlife Conservation Commission for providing financial support for this research, and Jun Wu and Youjian Lin for their technical assistance with chemical analysis. NR 24 TC 1 Z9 1 U1 0 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PD JUN 18 PY 2013 VL 76 IS 12 BP 716 EP 722 DI 10.1080/15287394.2013.802266 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 207VG UT WOS:000323632200002 PM 23980838 ER PT J AU Chow, HM Horovitz, SG Carr, WS Picchioni, D Coddington, N Fukunaga, M Xu, YS Balkin, TJ Duyn, JH Braun, AR AF Chow, Ho Ming Horovitz, Silvina G. Carr, Walter S. Picchioni, Dante Coddington, Nate Fukunaga, Masaki Xu, Yisheng Balkin, Thomas J. Duyn, Jeff H. Braun, Allen R. TI Rhythmic alternating patterns of brain activity distinguish rapid eye movement sleep from other states of consciousness SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE EEG; fMRI; thalamus; slow-wave sleep; brain dynamics ID DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; HZ OSCILLATIONS; LOW-FREQUENCY; REM-SLEEP; MEMORY; FLUCTUATIONS; WAKEFULNESS; CORTICES; CORTEX AB Rapid eye movement (REM) sleep constitutes a distinct "third state" of consciousness, during which levels of brain activity are commensurate with wakefulness, but conscious awareness is radically transformed. To characterize the temporal and spatial features of this paradoxical state, we examined functional interactions between brain regions using fMRI resting-state connectivity methods. Supporting the view that the functional integrity of the default mode network (DMN) reflects "level of consciousness," we observed functional uncoupling of the DMN during deep sleep and recoupling during REM sleep (similar to wakefulness). However, unlike either deep sleep or wakefulness, REM was characterized by a more widespread, temporally dynamic interaction between two major brain systems: unimodal sensorimotor areas and the higher-order association cortices (including the DMN), which normally regulate their activity. During REM, these two systems become anticorrelated and fluctuate rhythmically, in reciprocally alternating multisecond epochs with a frequency ranging from 0.1 to 0.01 Hz. This unique spatiotemporal pattern suggests a model for REM sleep that may be consistent with its role in dream formation and memory consolidation. C1 [Chow, Ho Ming; Xu, Yisheng; Braun, Allen R.] Natl Inst Deafness & Other Commun Disorders, Language Sect, Voice Speech & Language Branch, NIH, Bethesda, MD 20892 USA. [Horovitz, Silvina G.] NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA. [Horovitz, Silvina G.; Fukunaga, Masaki; Duyn, Jeff H.] NINDS, Sect Adv MRI, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA. [Carr, Walter S.; Picchioni, Dante; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Coddington, Nate] Univ Virginia, Dept Neurosci, Charlottesville, VA 22903 USA. [Fukunaga, Masaki] Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Osaka 5650871, Japan. RP Chow, HM (reprint author), Natl Inst Deafness & Other Commun Disorders, Language Sect, Voice Speech & Language Branch, NIH, Bethesda, MD 20892 USA. EM chowh@nidcd.nih.gov RI Fukunaga, Masaki/F-6441-2013 OI Fukunaga, Masaki/0000-0003-1010-2644 FU National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke; Walter Reed Army Institute of Research FX The authors thank Carmen Brewer, Christopher Zalewski, Teresa Kessinger, and Jim Paterson for key collaboration and support; and Alex Martin and Kelly Barnes for insightful and critical reviews of this manuscript. This work was supported by the Intramural Research Programs of the National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, and the Walter Reed Army Institute of Research. NR 39 TC 35 Z9 35 U1 4 U2 37 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 18 PY 2013 VL 110 IS 25 BP 10300 EP 10305 DI 10.1073/pnas.1217691110 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 179DU UT WOS:000321500200062 PM 23733938 ER PT J AU Convertino, M Valverde, LJ AF Convertino, Matteo Valverde, L. James, Jr. TI Portfolio Decision Analysis Framework for Value-Focused Ecosystem Management SO PLOS ONE LA English DT Article ID EVOLUTIONARY MULTIOBJECTIVE OPTIMIZATION; BIODIVERSITY CONSERVATION; EXTINCTION RISK; CLIMATE-CHANGE; PARETO FRONT; LAND-USE; UNCERTAINTY; DESIGN; DIVERSIFICATION; SYSTEMS AB Management of natural resources in coastal ecosystems is a complex process that is made more challenging by the need for stakeholders to confront the prospect of sea level rise and a host of other environmental stressors. This situation is especially true for coastal military installations, where resource managers need to balance conflicting objectives of environmental conservation against military mission. The development of restoration plans will necessitate incorporating stakeholder preferences, and will, moreover, require compliance with applicable federal/state laws and regulations. To promote the efficient allocation of scarce resources in space and time, we develop a portfolio decision analytic (PDA) framework that integrates models yielding policy-dependent predictions for changes in land cover and species metapopulations in response to restoration plans, under different climate change scenarios. In a manner that is somewhat analogous to financial portfolios, infrastructure and natural resources are classified as human and natural assets requiring management. The predictions serve as inputs to a Multi Criteria Decision Analysis model (MCDA) that is used to measure the benefits of restoration plans, as well as to construct Pareto frontiers that represent optimal portfolio allocations of restoration actions and resources. Optimal plans allow managers to maintain or increase asset values by contrasting the overall degradation of the habitat and possible increased risk of species decline against the benefits of mission success. The optimal combination of restoration actions that emerge from the PDA framework allows decision-makers to achieve higher environmental benefits, with equal or lower costs, than those achievable by adopting the myopic prescriptions of the MCDA model. The analytic framework presented here is generalizable for the selection of optimal management plans in any ecosystem where human use of the environment conflicts with the needs of threatened and endangered species. The PDA approach demonstrates the advantages of integrated, top-down management, versus bottom-up management approaches. C1 [Convertino, Matteo] Univ Florida, Inst Food & Agr Sci, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Convertino, Matteo] Univ Florida, Florida Climate Inst, Gainesville, FL 32611 USA. [Valverde, L. James, Jr.] USA, Corps Engineers, Engineer Res & Dev Ctr, HQ, Washington, DC 20310 USA. RP Convertino, M (reprint author), Univ Florida, Inst Food & Agr Sci, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu FU Center Directed Research (ERDC/USACE CDR) Program; Strategic Environmental Research and Development Program (SERDP) [1699] FX Funding from the Center Directed Research (ERDC/USACE CDR) Program and Strategic Environmental Research and Development Program (SERDP) 1699 Program supported this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 80 TC 11 Z9 11 U1 4 U2 50 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 18 PY 2013 VL 8 IS 6 AR e65056 DI 10.1371/journal.pone.0065056 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 166SA UT WOS:000320576400004 PM 23823331 ER PT J AU Zeng, CC Hossieny, N Zhang, C Wang, B Walsh, SM AF Zeng, Changchun Hossieny, Nemat Zhang, Chuck Wang, Ben Walsh, Shawn M. TI Morphology and tensile properties of PMMA carbon nanotubes nanocomposites and nanocomposites foams SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Polymers; Nanocomposites; Carbon nanotubes; Mechanical properties ID MECHANICAL-PROPERTIES; POLYURETHANE FOAM; POLY(METHYL METHACRYLATE); MICROCELLULAR FOAMS; FRACTURE-TOUGHNESS; POLYSTYRENE FOAMS; IMPACT PROPERTIES; POLYMERIC FOAMS; COMPOSITES; POLYCARBONATE AB Poly (methyl methacrylate) (PMMA) and multi-walled carbon nanotubes (MWCNTs) nanocomposites were synthesized and foamed by supercritical carbon dioxide. Morphology and tensile properties of both solid and foamed nanocomposites were investigated. Moderate improvement in the tensile properties was observed in the solid nanocomposites, which depended on carbon nanotube (CNT) dispersion and polymer-CNT interaction. The CNTs had significant influences on the foam cell morphology. Moreover, the convoluted effects of CNT dispersion, polymer-CNT interaction and foam structure differences led to significant difference in foam properties. Nanocomposite foam with concurrent increases in tensile strength (similar to 40%), tensile modulus (similar to 60%) and strain at break (similar to 70%) was successfully prepared with the use of 0.5% functionalized CNTs that were well dispersed. The foam showed a ductile failure under tension that involved extensive pore deformation and collapsing, and formation and coalescence of microvoids that were largely responsible for the significantly improved tensile toughness. By contrast, foam properties were reduced in the presence of poorly dispersed CNTs that weakly adhered to the matrix. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Zeng, Changchun; Hossieny, Nemat; Zhang, Chuck; Wang, Ben] Florida State Univ, High Performance Mat Inst, Tallahassee, FL 32310 USA. [Zeng, Changchun; Hossieny, Nemat; Zhang, Chuck; Wang, Ben] FAMU FSU Coll Engn, Dept Ind & Mfg Engn, Tallahassee, FL 32310 USA. [Walsh, Shawn M.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zeng, CC (reprint author), FAMU FSU Coll Engn, Dept Ind & Mfg Engn, 2525 Pottsdamer St, Tallahassee, FL 32310 USA. EM zeng@eng.fsu.edu FU US Army Research Lab; Center of Excellence in Advanced Materials program from the State of Florida FX Funding from US Army Research Lab, and Center of Excellence in Advanced Materials program from the State of Florida was acknowledged. NR 58 TC 14 Z9 16 U1 1 U2 80 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN 18 PY 2013 VL 82 BP 29 EP 37 DI 10.1016/j.compscitech.2013.03.024 PG 9 WC Materials Science, Composites SC Materials Science GA 173LL UT WOS:000321080900005 ER PT J AU Hill, KK Smith, TJ Ticknor, LO Foley, BT Xie, G AF Hill, K. K. Smith, T. J. Ticknor, L. O. Foley, B. T. Xie, G. TI Genetic diversity between and within botulinum neurotoxin serotypes SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Hill, K. K.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM USA. [Smith, T. J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Ticknor, L. O.] Los Alamos Natl Lab, Comp Computat & Stat Sci Div, Los Alamos, NM USA. [Foley, B. T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA. [Xie, G.] Los Alamos Natl Lab, DOE Joint Genome Inst, Los Alamos, NM USA. OI Ticknor, Lawrence/0000-0002-7967-7908; xie, gary/0000-0002-9176-924X NR 0 TC 0 Z9 0 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 60 EP 61 DI 10.1016/j.toxicon.2012.07.021 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500009 ER PT J AU Grogan, PM Alvarez, MV AF Grogan, P. M. Alvarez, M. V. TI RimabotulinumtoxinB for preventive treatment of migraine headaches SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Grogan, P. M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Alvarez, M. V.] Ctr Neurol Care & Res, San Antonio, TX USA. EM patrick.grogan@sbcglobal.net NR 0 TC 0 Z9 0 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 74 EP 75 DI 10.1016/j.toxicon.2012.07.055 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500043 ER PT J AU Kalb, SR Baudys, J Webb, RP Wright, P Smith, TJ Smith, LA Fernandez, R Raphael, BH Maslanka, SE Barr, JR AF Kalb, S. R. Baudys, J. Webb, R. P. Wright, P. Smith, T. J. Smith, L. A. Fernandez, R. Raphael, B. H. Maslanka, S. E. Barr, J. R. TI Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5 SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Kalb, S. R.; Baudys, J.; Barr, J. R.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Webb, R. P.; Wright, P.; Smith, T. J.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Smith, T. J.] Med Res & Mat Command, Off Chief Scientist, Ft Detrick, MD USA. [Fernandez, R.] Univ Nacl Cuyo, Fac Ciencias Med, Area Micro Biol, RA-5500 Mendoza, Argentina. [Raphael, B. H.; Maslanka, S. E.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. EM skalb@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 76 EP 77 DI 10.1016/j.toxicon.2012.07.059 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500047 ER PT J AU McNutt, P Lyman, M Tuznik, K Mesngon, M AF McNutt, P. Lyman, M. Tuznik, K. Mesngon, M. TI Sensitivity and persistence in BoNT-Treated embryonic stem cell-derived neurons SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [McNutt, P.; Lyman, M.; Tuznik, K.; Mesngon, M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM patrick.mcnutt@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 78 EP 78 DI 10.1016/j.toxicon.2012.07.063 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500051 ER PT J AU Adler, M Deshpande, SS Apland, JP AF Adler, M. Deshpande, S. S. Apland, J. P. TI Simultaneous or sequential injection of botulinum neurotoxin A does not reduce the duration of paralysis by botulinum neurotoxin A in rat EDL muscle SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Adler, M.; Deshpande, S. S.; Apland, J. P.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. EM michael.adler2@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 81 EP 81 DI 10.1016/j.toxicon.2012.07.068 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500056 ER PT J AU Apland, JP Ferrara, TM Borrell, AC Adler, M AF Apland, J. P. Ferrara, T. M. Borrell, A. C. Adler, M. TI Effect of growth factors on recovery from botulinum neurotoxin-induced paralysis SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Apland, J. P.; Ferrara, T. M.; Borrell, A. C.; Adler, M.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. EM james.p.apland@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 81 EP 81 DI 10.1016/j.toxicon.2012.07.069 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500057 ER PT J AU Chambers, C Garcia, GE AF Chambers, C. Garcia, G. E. TI Molecular pharmacophores against BoNT/B SO TOXICON LA English DT Meeting Abstract CT 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS) CY OCT 02-05, 2011 CL Santa Fe, NM C1 [Chambers, C.; Garcia, G. E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM carolyn.chambers1@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 15 PY 2013 VL 68 BP 82 EP 83 DI 10.1016/j.toxicon.2012.07.072 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 159VN UT WOS:000320075500060 ER EF