FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Calabrese, E Du, F Garman, RH Johnson, GA Riccio, C Tong, LC Long, JB AF Calabrese, Evan Du, Fu Garman, Robert H. Johnson, G. Allan Riccio, Cory Tong, Lawrence C. Long, Joseph B. TI Diffusion Tensor Imaging Reveals White Matter Injury in a Rat Model of Repetitive Blast-Induced Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE voxelwise analysis; MRI; diffusion tensor imaging; blast neurotrauma; traumatic brain injury ID MAGNETIC-RESONANCE HISTOLOGY; CLOSED-HEAD INJURY; AXONAL INJURY; MOUSE MODEL; INTRACRANIAL-PRESSURE; BATTLEFIELD INJURY; OPTIC-NERVE; MRI DATA; EXPOSURE; IRAQ AB Blast-induced traumatic brain injury (bTBI) is one of the most common combat-related injuries seen in U.S. military personnel, yet relatively little is known about the underlying mechanisms of injury. In particular, the effects of the primary blast pressure wave are poorly understood. Animal models have proven invaluable for the study of primary bTBI, because it rarely occurs in isolation in human subjects. Even less is known about the effects of repeated primary blast wave exposure, but existing data suggest cumulative increases in brain damage with a second blast. MRI and, in particular, diffusion tensor imaging (DTI), have become important tools for assessing bTBI in both clinical and preclinical settings. Computational statistical methods such as voxelwise analysis have shown promise in localizing and quantifying bTBI throughout the brain. In this study, we use voxelwise analysis of DTI to quantify white matter injury in a rat model of repetitive primary blast exposure. Our results show a significant increase in microstructural damage with a second blast exposure, suggesting that primary bTBI may sensitize the brain to subsequent injury. C1 [Calabrese, Evan; Johnson, G. Allan] Duke Univ, Med Ctr, Dept Radiol, Ctr In Vivo Microscopy, Durham, NC 27710 USA. [Du, Fu] FD NeuroTechnol Inc, Ellicott City, MD USA. [Garman, Robert H.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA USA. [Riccio, Cory; Tong, Lawrence C.; Long, Joseph B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Long, JB (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Robert Grant Ave,Bldg 503, Silver Spring, MD 20910 USA. EM joseph.long@us.army.mil FU CDMRP Psychological Health and Traumatic Brain Injury Research Program [W81XWH-11-2-0127] FX Blast exposure was performed at the Walter Reed Army Institute of Research under the support of the CDMRP Psychological Health and Traumatic Brain Injury Research Program (W81XWH-11-2-0127). Imaging work was performed at the Duke University Center for In Vivo Microscopy, an NIH/NIBIB Biomedical Technology Resource Center (P41 EB015897). We are grateful to Sally Gewalt and James Cook for assistance with the imaging pipelines. We thank Andrea Edwards, Joseph Andrist, and Donna Wilder for assistance with blast exposures, and Dr. Yi Qi, and Gary Cofer for assistance in specimen preparation and scanning. NR 69 TC 17 Z9 17 U1 2 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY 15 PY 2014 VL 31 IS 10 BP 938 EP 950 DI 10.1089/neu.2013.3144 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AH1ES UT WOS:000335863200006 PM 24392843 ER PT J AU Walsh, LA Hurley, PK Lin, J Cockayne, E O'Regan, TP Woicik, JC Hughes, G AF Walsh, Lee A. Hurley, Paul K. Lin, Jun Cockayne, Eric O'Regan, T. P. Woicik, Joseph C. Hughes, Greg TI A spectroscopic method for the evaluation of surface passivation treatments on metal-oxide-semiconductor structures SO APPLIED SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 8th International Workshop on Semiconductor Surface Passivation (SSP) CY SEP 08-12, 2013 CL Silesian Univ Technol, Inst Elect, Krakow, POLAND SP European Ctr Excellence Phys & Technol Semicond Interfaces & Sensors, Polish Vacuum Soc, SPECS, Uni Export Instruments HO Silesian Univ Technol, Inst Elect DE Hard x-ray photoelectron spectroscopy; Electrical characterisation; X-ray photoelectron spectroscopy; Surface passivation ID RAY PHOTOELECTRON-SPECTROSCOPY; P-B CENTERS; SYNCHROTRON-RADIATION; VALENCE-BAND; IN-SITU; INTERFACES; SILICON; LEVEL; PHOTOEMISSION; PHOTOVOLTAGE AB Combined hard x-ray photoelectron spectroscopy (HAXPES) and electrical characterisation measurements have been shown to provide complementary information on the electrical performance of Si and GaAs based metal-oxide-semiconductor (MOS) structures. The results obtained indicate that surface potential changes at the semiconductor/dielectric interface due to the presence of different work function metals can be detected from HAXPES measurements. Changes in the semiconductor band bending at zero gate voltage and the flat band voltage values derived from C-V measurements are in agreement with the semiconductor core level shifts measured from the HAXPES spectra. These results highlight the potential application of this measurement approach in the evaluation of the efficacy of surface passivation treatments: HAXPES hard x-ray photoelectron spectroscopy; C-V capacitance voltage; D-it-interface state density; BE binding energy, at reducing defect states densities in MOS structures. (C) 2014 Elsevier B.V. All rights reserved. C1 [Walsh, Lee A.; Hughes, Greg] Dublin City Univ, Sch Phys Sci, Dublin 9, Ireland. [Hurley, Paul K.; Lin, Jun] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. [Cockayne, Eric; Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA. [O'Regan, T. P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Walsh, LA (reprint author), Dublin City Univ, Sch Phys Sci, Dublin 9, Ireland. EM lee.walsh36@mail.dcu.ie OI Hughes, Greg/0000-0003-1310-8961; Hughes, Gregory/0000-0002-1358-9032 NR 36 TC 0 Z9 0 U1 2 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 EI 1873-5584 J9 APPL SURF SCI JI Appl. Surf. Sci. PD MAY 15 PY 2014 VL 301 SI SI BP 40 EP 45 DI 10.1016/j.apsusc.2014.01.208 PG 6 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AG0HD UT WOS:000335095600008 ER PT J AU Farlow, J Filippov, AA Sergueev, KV Hang, J Kotorashvili, A Nikolich, MP AF Farlow, Jason Filippov, Andrey A. Sergueev, Kirin V. Hang, Jun Kotorashvili, Adam Nikolich, Mikeljon P. TI Comparative whole genorne analysis of six diagnostic brucellaphages SO GENE LA English DT Article DE Brucellaphage; Brucella; Bacteriophage; Comparative genomics ID CARRIER STATE; PHAGE; BACTERIOPHAGE; ABORTUS; MECHANISM; CULTURES; SUIS AB Whole genome sequencing of six diagnostic brucellaphages, Tbilisi (Tb), Firenze (Fz), Weybridge (Wb), S708, Berkeley (Bk) and R/C, was followed with genomic comparisons including recently described genomes of the Tb phage from Mexico (Tb-M) and Pr phage to elucidate genomic diversity and candidate host range determinants. Comparative whole genome analysis revealed high sequence homogeneity among these brucellaphage genomes and resolved three genetic groups consistent with defined host range phenotypes. Group I was composed of Tb and Fz phages that are predominantly lytic for Brucella abortus and Brucella neotomae; Group II included Bk, R/C, and Pr phages that are lytic mainly for B. abortus, Brucella melitensis and Brucella suis; Group III was composed of Wb and S708 phages that are lytic for B. suis, B. abortus and B. neotomae. We found that the putative phage collar protein is a variable locus with features that may be contributing to the host specificities exhibited by different brucellaphage groups. The presence of several candidate host range determinants is illustrated herein for future dissection of the differential host specificity observed among these phages. Published by Elsevier B.V. C1 [Farlow, Jason] Ilia State Univ, Tbilisi, Rep of Georgia. [Filippov, Andrey A.; Sergueev, Kirin V.; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Hang, Jun] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Kotorashvili, Adam] Richard G Lugar Ctr Publ Hlth Res, Tbilisi, Rep of Georgia. RP Nikolich, MP (reprint author), Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mikeljon.p.nikolich.civ@mail.mil FU Defense Threat Reduction Agency project [CBCALL12-DIAGB1-2-0194] FX We thank Ms. Yu Yang, Dr Yanfei Zhou, MAJ Richard G. Jarman and LTC Stephen Thomas for technical and material support for the 454 sequencing. This work was also supported by the Defense Threat Reduction Agency project CBCALL12-DIAGB1-2-0194. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the U.S. Army or the U.S. Department of Defense. NR 36 TC 4 Z9 6 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 EI 1879-0038 J9 GENE JI Gene PD MAY 15 PY 2014 VL 541 IS 2 BP 115 EP 122 DI 10.1016/j.gene.2014.01.018 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA AG0JR UT WOS:000335102300007 PM 24530704 ER PT J AU Allen, JL Thompson, T Sakamoto, J Becker, CR Jow, TR Wolfenstine, J AF Allen, Jan L. Thompson, Travis Sakamoto, Jeff Becker, Collin R. Jow, T. Richard Wolfenstine, Jeff TI Transport properties of LiCoPO4 and Fe-substituted LiCoPO4 SO JOURNAL OF POWER SOURCES LA English DT Article DE Li-ion; Battery; Cathode; Ionic; Electronic; Conductivity ID ELECTRONIC CONDUCTIVITY; AC-IMPEDANCE; ELECTROCHEMICAL PERFORMANCE; ELECTRICAL-CONDUCTIVITY; DISCHARGE CAPACITY; CATHODE MATERIALS; BETA-ALUMINA; CONDUCTORS; BATTERIES; BEHAVIOR AB LiCoPO4 is a promising cathode material to enable high energy, abuse tolerant Li-ion batteries. However, LiCoPO4 has relatively poor electronic conductivity which may be improved by chemical substitution. In this work, the ionic and electronic conductivities of dense, polycrystalline LiCoPO4 and Fe2+/Fe3+-substituted LiCoPO4 (Li(1-)xCo(0.9)Fe(0.1)PO(4)) are measured and compared. Both materials are predominantly ionic conductors with relatively good bulk ionic and relatively poor electronic conductivities. Li(1-)xCo(0.9)Fe(0.1)PO(4) exhibits both higher bulk ionic and electronic conductivity. The increased bulk ionic conductivity of Li(1-)xCo(0.9)Fe(0.1)PO(4) is believed to originate mainly from extra Li vacancies and the increased electronic conductivity is believed to originate mainly from creating more mobile hole polarons compared to LiCoPO4 as a result of Fe2+/Fe3+ substitution. Published by Elsevier B.V. C1 [Allen, Jan L.; Becker, Collin R.; Jow, T. Richard; Wolfenstine, Jeff] US Army, Res Lab, Adelphi, MD 20783 USA. [Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Allen, JL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jan.l.allen8.civ@mail.mil FU U.S. Army Research Laboratory (ARL) FX JLA, CRB, TRJ and JW acknowledge support of the U.S. Army Research Laboratory (ARL). NR 30 TC 11 Z9 11 U1 8 U2 103 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAY 15 PY 2014 VL 254 BP 204 EP 208 DI 10.1016/j.jpowsour.2013.12.111 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA AC4MV UT WOS:000332496300026 ER PT J AU Sundaram, HS Han, X Nowinski, AK Ella-Menye, JR Wimbish, C Marek, P Senecal, K Jiang, SY AF Sundaram, Harihara S. Han, Xia Nowinski, Ann K. Ella-Menye, Jean-Rene Wimbish, Collin Marek, Patrick Senecal, Kris Jiang, Shaoyi TI One-Step Dip Coating of Zwitterionic Sulfobetaine Polymers on Hydrophobic and Hydrophilic Surfaces SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE sulfobetaine; zwitterionic polymer; dip coating; DOPA binding; nonfouling; hydrophobic surfaces ID SELF-ASSEMBLED MONOLAYERS; BIOMIMETIC ADHESIVE GROUP; NONFOULING MATERIALS; MUSSEL ADHESION; PHASE-BEHAVIOR; ADSORPTION; PROTEINS; BRUSHES; POLYMERIZATION; RESISTANCE AB Zwitterionic sulfobetaine polymers with a catechol chain end (DOPA-PSB) were applied to a variety of hydrophobic polymer sheets and fibers. In addition, a silica surface was tested as a representative hydrophilic substrate. The polymer-coated surfaces showed significantly lower fouling levels than uncoated controls. Because of the anti-polyelectrolyte nature of sulfobetaine zwitterionic polymers, the effect of salt concentration on the coating solutions and the quality of the polymer coating against fouling are studied. The coating method involves only water-based solutions, which is compatible with most surfaces and is environmentally friendly. To demonstrate the versatility of the reported method, we evaluated the fouling levels of the polymer coating on commonly used polymeric surfaces such as polypropylene (PP), polydirnethylsiloxane (PDMS), polystyrene (PS), nylon, polyvinyl chloride (PVC), and poly(methyl methacrylate) (PMMA). C1 [Sundaram, Harihara S.; Han, Xia; Nowinski, Ann K.; Ella-Menye, Jean-Rene; Wimbish, Collin; Jiang, Shaoyi] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. [Han, Xia] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China. [Han, Xia] E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China. [Marek, Patrick; Senecal, Kris] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. RP Jiang, SY (reprint author), Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. EM sjiang@uw.edu FU National Science Foundation [CMMI-1301435]; U.S. Army Natick Soldier Research, Development and Engineering Center; Defense Advanced Research Projects Agency [N66001-12-1-4263]; National Natural Science Foundation of China [21176065]; Shanghai Municipal Education Commission FX This work was supported by the National Science Foundation (CMMI-1301435), the U.S. Army Natick Soldier Research, Development and Engineering Center and the Defense Advanced Research Projects Agency (N66001-12-1-4263). X.H. acknowledges financial support from the National Natural Science Foundation of China (21176065) and Shanghai Municipal Education Commission. NR 42 TC 33 Z9 33 U1 20 U2 199 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY 14 PY 2014 VL 6 IS 9 BP 6664 EP 6671 DI 10.1021/am500362k PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA AH4CV UT WOS:000336075300080 PM 24730392 ER PT J AU Cole, DP Strawhecker, KE AF Cole, Daniel P. Strawhecker, Kenneth E. TI An improved instrumented indentation technique for single microfibers SO JOURNAL OF MATERIALS RESEARCH LA English DT Article DE nanoindentation; microfiber; fiber mounting technique; atomic force microscope; processing; structure; property relationship ID MOLECULAR-WEIGHT POLYETHYLENE; NANOSCALE MECHANICAL CHARACTERIZATION; ATOMIC-FORCE MICROSCOPY; FIBERS; NANOINDENTATION; MODULUS; FILMS; POLY(P-PHENYLENETEREPHTHALAMIDE); SUBSTRATE; DYNAMICS AB We describe an improved experimental approach for characterizing the elastic modulus and hardness of single microfibers through instrumented indentation. A sample mounting technique on a curved surface is presented that ensures contact between an unmodified fiber and substrate. The indentation analysis considers three separate corrections to the well-known Oliver and Pharr method: (i) overestimation of the projected contact area due to sample curvature, (ii) overestimation of projected contact area due to substrate curvature, and (iii) underestimation of fiber stiffness due to the structural compliance of the sample. The method is applied to four types of high performance ballistic fibers: KM2 Plus, Twaron, AuTx, and Dyneema; the results are presented according to both the modified analyses as well as the standard Oliver and Pharr analysis. The modified analyses resulted in an increase in the elastic modulus and hardness of up to 35 and 60%, respectively, compared to the Oliver-Pharr method. The technique has the potential to be applied to single microfilaments under various environmental conditions that may otherwise be compromised by traditional fiber mounting methods. C1 [Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Strawhecker, Kenneth E.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Strawhecker, KE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kenneth.e.strawhecker.civ@mail.mil FU U.S. Army Research Laboratory [NNL09AA00A] FX Daniel P. Cole is a contractor to the U.S. Army Research Laboratory under contract NNL09AA00A. The authors also wish to acknowledge Dr. Q. P. McAllister for helpful discussions during this work. NR 37 TC 9 Z9 9 U1 3 U2 21 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD MAY 14 PY 2014 VL 29 IS 9 BP 1104 EP 1112 DI 10.1557/jmr.2014.83 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA AH5ZS UT WOS:000336211000010 ER PT J AU Sliozberg, YR Hoy, RS Mrozek, RA Lenhart, JL Andzelm, JW AF Sliozberg, Yelena R. Hoy, Robert S. Mrozek, Randy A. Lenhart, Joseph L. Andzelm, Jan W. TI Role of entanglements and bond scission in high strain-rate deformation of polymer gels SO POLYMER LA English DT Article DE Polymer gels; Molecular dynamics simulations; Bond scission ID DOUBLE NETWORK GELS; MOLECULAR-DYNAMICS; MECHANICAL-PROPERTIES; ELASTIC-MATERIALS; FRACTURE; SOLVENT; ADHESION; BEHAVIOR; MODEL; MELTS AB A key factor that limits the practical implementation of polymer gels is low gel toughness. Here, we present coarse-grained molecular dynamics simulations of the effects of solvent molecular weight on the toughness of entangled and non-entangled polymer gels in the ballistic impact regime. Our results demonstrate that higher molecular weight solvents enhance gel toughness, and that mechanical properties including strength and toughness can be influenced by bond scission. Further, we find a remarkable two-step gel fracture mechanism on the molecular level: network chains undergo scission first (and well before fracture), followed by scission of solvent chains. For strain rates greater than inverse relaxation time of the solvent, long, highly entangled solvent chains provide fracture resistance even after the network chains break by effectively increasing the number of chains that must be broken as a crack propagates. (c) 2014 Elsevier Ltd. All rights reserved. C1 [Sliozberg, Yelena R.; Mrozek, Randy A.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sliozberg, Yelena R.] Bowhead Sci & Technol LLC, King George, VA 22485 USA. [Hoy, Robert S.] Univ S Florida, Dept Phys, Tampa, FL 33620 USA. RP Sliozberg, YR (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM yelena.r.sliozberg.ctr@mail.mil; jan.w.andzelm.civ@mail.mil NR 55 TC 5 Z9 5 U1 5 U2 50 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD MAY 13 PY 2014 VL 55 IS 10 BP 2543 EP 2551 DI 10.1016/j.polymer.2014.03.051 PG 9 WC Polymer Science SC Polymer Science GA AH2FI UT WOS:000335936500032 ER PT J AU Nuss, JE Kehn-Hall, K Benedict, A Costantino, J Ward, M Peyser, BD Retterer, CJ Tressler, LE Wanner, LM McGovern, HF Zaidi, A Anthony, SM Kota, KP Bavari, S Hakami, RM AF Nuss, Jonathan E. Kehn-Hall, Kylene Benedict, Ashwini Costantino, Julie Ward, Michael Peyser, Brian D. Retterer, Cary J. Tressler, Lyal E. Wanner, Laura M. McGovern, Hugh F. Zaidi, Anum Anthony, Scott M. Kota, Krishna P. Bavari, Sina Hakami, Ramin M. TI Multi-Faceted Proteomic Characterization of Host Protein Complement of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Important Viral Host Factors SO PLOS ONE LA English DT Article ID OXIDATIVELY DAMAGED PROTEINS; MASS-SPECTROMETRY ANALYSIS; TRANSPORT CHAIN COMPLEXES; RAPID DETECTION; CYCLOPHILIN-A; HIV-1 VIRIONS; LASSA VIRUS; CELLS; INFECTION; REPLICATION AB Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can cause near 100% abortion rates and recent outbreaks in naive human populations have suggested case fatality rates of greater than thirty percent. To elucidate the roles that host proteins play during RVFV infection, proteomic analysis of RVFV virions was conducted using complementary analytical approaches, followed by functional validation studies of select identified host factors. Coupling the more traditional Gel LC/MS/MS approach (SDS PAGE followed by liquid chromatography tandem mass spectrometry) with an alternative technique that preserves protein complexes allowed the protein complement of these viral particles to be thoroughly examined. In addition to viral proteins present within the virions and virion-associated host proteins, multiple macromolecular complexes were identified. Bioinformatic analysis showed that host chaperones were among over-represented protein families associated with virions, and functional experiments using siRNA gene silencing and small molecule inhibitors identified several of these heat shock proteins, including heat shock protein 90 (HSP90), as important viral host factors. Further analysis indicated that HSP inhibition effects occur during the replication/transcription phase of the virus life cycle, leading to significant lowering of viral titers without compromising the functional capacity of released virions. Overall, these studies provide much needed further insight into interactions between RVFV and host cells, increasing our understanding of the infection process and suggesting novel strategies for anti-viral development. In particular, considering that several HSP90 inhibitors have been advancing through clinical trials for cancer treatment, these results also highlight the exciting potential of repurposing HSP90 inhibitors to treat RVF. C1 [Nuss, Jonathan E.; Costantino, Julie; Ward, Michael; Peyser, Brian D.; Retterer, Cary J.; Tressler, Lyal E.; Wanner, Laura M.; McGovern, Hugh F.; Zaidi, Anum; Kota, Krishna P.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21701 USA. [Kehn-Hall, Kylene; Benedict, Ashwini; Hakami, Ramin M.] George Mason Univ, Sch Syst Biol, Manassas, VA USA. [Kehn-Hall, Kylene; Benedict, Ashwini; Hakami, Ramin M.] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. [Anthony, Scott M.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21701 USA. EM sina.bavari@us.army.mil; rhakami@gmu.edu RI Kehn-Hall, Kylene/I-5752-2013; OI Peyser, Brian/0000-0002-3455-5181 FU U.S. Army Medical Research and Materiel Command (MRMC) [W81XWH-11-P-0310]; George Mason University; Defense Threat Reduction Agency Transformational Medical Technologies [TMTI0048_09_RD_T] FX This research was supported by funding awarded to R.M.H. by the U.S. Army Medical Research and Materiel Command (MRMC) (W81XWH-11-P-0310) and George Mason University, and by a grant awarded to S.B. from the Defense Threat Reduction Agency Transformational Medical Technologies [TMTI0048_09_RD_T]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 6 Z9 6 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 8 PY 2014 VL 9 IS 5 AR e93483 DI 10.1371/journal.pone.0093483 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK1XT UT WOS:000338213300004 PM 24809507 ER PT J AU Beurskens, R Wilken, JM Dingwell, JB AF Beurskens, Rainer Wilken, Jason M. Dingwell, Jonathan B. TI Dynamic stability of individuals with transtibial amputation walking in destabilizing environments SO JOURNAL OF BIOMECHANICS LA English DT Article DE Gait; Amputation; Dynamic stability; Perturbations; Virtual reality ID LOWER-LIMB AMPUTATION; OLDER-ADULTS; GAIT CHARACTERISTICS; RISK-FACTORS; LATERAL STABILIZATION; MUSCLE COORDINATION; HEALTHY-ADULTS; ROCK SURFACE; AMPUTEES; VARIABILITY AB Lower limb amputation substantially disrupts motor and proprioceptive function. People with lower limb amputation experience considerable impairments in walking ability, including increased fall risk. Understanding the biomechanical aspects of the gait of these patients is crucial in improving their gait function and their quality of life. In the present study, 9 persons with unilateral transtibial amputation and 13 able-bodied controls walked on a large treadmill in a Computer Assisted Rehabilitation Environment (CAREN). While walking, subjects were either not perturbed, or were perturbed either by continuous mediolateral platform movements or by continuous mediolateral movements of the visual scene. Means and standard deviations of both step lengths and step widths increased significantly during both perturbation conditions (all p < 0.001) for both groups. Measures of variability, local and orbital dynamic stability of trunk movements likewise exhibited large and highly significant increases during both perturbation conditions (all p <0.001) for both groups. Patients with amputation exhibited greater step width variability (p = 0.01) and greater trunk movement variability (p = 0.04) during platform perturbations, but did not exhibit greater local or orbital instability than healthy controls for either perturbation conditions. Our findings suggest that, in the absence of other co-morbidities, patients with unilateral transtibial amputation appear to retain sufficient sensory and motor function to maintain overall upper body stability during walking, even when substantially challenged. Additionally, these patients did not appear to rely more heavily on visual feedback to maintain trunk stability during these walking tasks. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Beurskens, Rainer; Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Wilken, Jason M.] Brooke Army Med Ctr, Mil Performance Lab, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Dingwell, JB (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. EM jdingwell@austin.utexas.edu OI Wilken, Jason/0000-0002-5556-7667; Beurskens, Rainer/0000-0002-4512-4491; Dingwell, Jonathan/0000-0001-6990-4153 FU National Institutes of Health (NIH) [1-R01-HD059844] FX This study was supported by the National Institutes of Health (NIH) Grant 1-R01-HD059844 (to JBD and JMW). The authors thank Emily Sinitski and Kevin Terry for their assistance with data collection and processing. NR 60 TC 14 Z9 14 U1 0 U2 49 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD MAY 7 PY 2014 VL 47 IS 7 BP 1675 EP 1681 DI 10.1016/j.jbiomech.2014.02.033 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AI6VY UT WOS:000337016300016 PM 24679710 ER PT J AU Parsons, P Duncan, K Giri, AK Xiao, JQ Karna, SP AF Parsons, P. Duncan, K. Giri, A. K. Xiao, J. Q. Karna, S. P. TI Electromagnetic properties of NiZn ferrite nanoparticles and their polymer composites SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 58th Annual Conference on Magnetism and Magnetic Materials CY NOV 04-08, 2013 CL Denver, CO ID MAGNETIC-PROPERTIES AB The magnetic properties of polycrystalline NiZn ferrite nanoparticles synthesized using a polyol-reduction and coprecipitation reaction methods have been investigated. The effects on magnetization of synthesis approach, chemical composition, processing conditions, and on the size of nanoparticles on magnetization have been investigated. The measured room-temperature magnetization for the as-prepared magnetic nanoparticles (MNP) synthesized via polyol-reduction and coprecipitation is 69 Am-2 kg(-1) and 14 Am-2 kg(-1), respectively. X-ray diffraction measurements confirm spinel structure of the particles with an estimated grain size of similar to 80 nm obtained from the polyol-reduction and 28 nm obtained from these coprecipitation techniques. Upon calcination under atmospheric conditions at different temperatures between 800 degrees C and 1000 degrees C, the magnetization, M, of the coprecipitated MNP increases to 76 Am-2 kg(-1) with an estimated grain size of 90 nm. The MNP-polymer nanocomposites made from the synthesized MNP in various loading fraction and high density polyethylene exhibit interesting electromagnetic properties. The measured permeability and permittivity of the magnetic nanoparticle-polymer nanocomposites increases with the loading fractions of the magnetic nanoparticles, suggesting control for impedance matching for antenna applications. C1 [Parsons, P.; Giri, A. K.; Karna, S. P.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Parsons, P.; Xiao, J. Q.] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Duncan, K.] US Army, Commun Elect Res Dev & Engn Ctr, Space & Terr Commun Directorate, Aberdeen Proving Ground, MD 21005 USA. [Giri, A. K.] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. RP Karna, SP (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM shashi.p.karna.civ@mail.mil FU U.S. Army Communications-Electronics Research, Development and Engineering Center, Space and Terrestrial Communications Directorate FX The research conducted at the U.S. Army Research Laboratory was partly funded by the U.S. Army Communications-Electronics Research, Development and Engineering Center, Space and Terrestrial Communications Directorate. The authors would like to thank Mr. Robert Schmidt (University of Delaware) for the contribution of TEM imaging. NR 26 TC 4 Z9 4 U1 0 U2 23 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2014 VL 115 IS 17 AR 173905 DI 10.1063/1.4873235 PG 8 WC Physics, Applied SC Physics GA AG8BO UT WOS:000335643700620 ER PT J AU Yin, XL Skomski, R Sellmyer, D Liou, SH Russek, SE Evarts, ER Moreland, J Edelstein, AS Yuan, L Yan, ML Shen, J AF Yin, Xiaolu Skomski, Ralph Sellmyer, David Liou, Sy-Hwang Russek, Stephen E. Evarts, Eric R. Moreland, John Edelstein, A. S. Yuan, L. Yan, M. L. Shen, J. TI Adjusting magnetic nanostructures for high-performance magnetic sensors SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 58th Annual Conference on Magnetism and Magnetic Materials CY NOV 04-08, 2013 CL Denver, CO ID TUNNELING JUNCTIONS AB The magnetic properties of the soft ferromagnetic layer in magnetic tunnel junctions are one of key factors to determine the performance of magnetoresistance sensors. We use a three-step orthogonal annealing procedure to modify the nanostructures of the free layer in the magnetic tunnel junction to control features such as magnetization reversal, coercivity, exchange field, and tunnel magnetoresistance ratio. We present a sensor with an improved sensitivity as high as 3944%/mT. This magnetic sensor only dissipates 200 mu W of power while operating under an applied voltage of 1 V. (C) 2014 AIP Publishing LLC. C1 [Yin, Xiaolu; Skomski, Ralph; Sellmyer, David; Liou, Sy-Hwang] Univ Nebraska, Dept Phys & Astron, Lincoln, NE 68588 USA. [Yin, Xiaolu; Skomski, Ralph; Sellmyer, David; Liou, Sy-Hwang] Univ Nebraska, Nebraska Ctr Mat & Nanosci, Lincoln, NE 68588 USA. [Russek, Stephen E.; Evarts, Eric R.; Moreland, John] NIST, Boulder, CO 80305 USA. [Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Yuan, L.; Yan, M. L.; Shen, J.] Western Digital Corp, Fremont, CA 94539 USA. RP Liou, SH (reprint author), Univ Nebraska, Dept Phys & Astron, Lincoln, NE 68588 USA. EM sliou@unl.edu FU DOD (ARO) [W911NF-09-0039, W911NF-10-2-0099] FX This work was supported by DOD (ARO, W911NF-09-0039, W911NF-10-2-0099), Western Digital Corporation for the fabrication of MTJ multilayer and NSF through Nebraska MRSEC (DMR-0820521) for magnetic characterizations. NR 25 TC 1 Z9 1 U1 3 U2 17 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2014 VL 115 IS 17 AR 17E528 DI 10.1063/1.4870315 PG 3 WC Physics, Applied SC Physics GA AG8BO UT WOS:000335643700549 ER PT J AU Jagodzinski, LL Liu, Y Hack, HR Kibirige, C Peel, SA Manak, MM AF Jagodzinski, Linda L. Liu, Ying Hack, Holly R. Kibirige, Catherine Peel, Sheila A. Manak, Mark M. TI Discrepant Amplification Results during the Development of an Assay Leads to Reclassification of Two AIDS Reagent Repository HIV-2 Isolates as HIV-1 SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-2; VIRAL LOAD ASSAY; CLINICAL-USE; INFECTION; QUANTIFICATION; VALIDATION AB The development and verification of HIV-2 assays depends in part on the availability of well-characterized samples, including those from reagent repositories. During the development of an HIV-2 RNA quantification assay, two HIV-2 viral isolates (CDC 301340 and CDC 301342) obtained from the NIAID AIDS Reagent and Reference Repository were not detected leading to an investigation. Two HIV-2 primers/probe sets of known performance in real-time viral RNA quantification assays, targeting different regions of the virus, also failed to generate RT-PCR products for these two isolates. These isolates were tested in the HIV-1 specific COBAS AmpliPrep/COBAS TaqMan HIV-1 Test v2.0 (Roche Molecular Diagnostics) and were quantified at high copy number. Other HIV-2 isolates tested were not amplified in the COBAS HIV-1 TaqMan assay. Furthermore, the discrepant isolates were highly reactive in an HIV-1 p24 antigen test while the other HIV-2 isolates showed very weak, if any, cross-reactivity with the HIV-1 p24 assay. Phylogenetic tree analysis of sequences from the protease-reverse transcriptase regions of the discrepant HIV-2 isolates mapped with HIV-1 Group M, Subtype CRF02_AG confirming these isolates were of HIV-1 origin and had been misclassified as HIV-2. The use of misclassified isolates in the verification of molecular and immunological assays can lead to misinterpretation of test results, misdirection of efforts into assay redesign and increased development costs. The results of this study were shared with the NIAID AIDS Reagent Program, leading to the reclassification of the two discrepant isolates as HIV-1. C1 [Jagodzinski, Linda L.; Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Liu, Ying; Hack, Holly R.; Kibirige, Catherine; Manak, Mark M.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Silver Spring, MD USA. RP Jagodzinski, LL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM ljagodzinski@hivresearch.org OI Manak, Mark /0000-0002-9217-9129 FU US Army Medical Research and Materiel Command [W81XWH-07-2-0067]; Henry M. Jackson Foundation for the Advancement of Military Research [W81XWH-07-2-0067]; US Army Medical Command FX This work was performed under a Cooperative Agreement W81XWH-07-2-0067 between the US Army Medical Research and Materiel Command and the Henry M. Jackson Foundation for the Advancement of Military Research and executed using funding provided by the US Army Medical Command. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 18 TC 0 Z9 0 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 5 PY 2014 VL 9 IS 5 AR e96554 DI 10.1371/journal.pone.0096554 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI1ZV UT WOS:000336656000093 PM 24797800 ER PT J AU Shen, TC Drost, RJ Davis, CC Sadler, BM AF Shen, Thomas C. Drost, Robert J. Davis, Christopher C. Sadler, Brian M. TI Design of dual-link (wide- and narrow-beam) LED communication systems SO OPTICS EXPRESS LA English DT Article ID WIRELESS NETWORKS; RF; LIGHT AB We explore the design of an LED-based communication system comprising two free space optical links: one narrow-beam (primary) link for bulk data transmission and one wide-beam (beacon) link for alignment and support of the narrow-beam link. Such a system combines the high throughput of a highly directional link with the robust insensitivity to pointing errors of a wider-beam link. We develop a modeling framework for this dual-link configuration and then use this framework to explore system tradeoffs in power, range, and achievable rates. The proposed design presents a low-cost, compact, robust means of communication at short-to medium-ranges, and calculations show that data rates on the order of Mb/s are achievable at hundreds of meters with only a few LEDs. (C) 2014 Optical Society of America C1 [Shen, Thomas C.; Davis, Christopher C.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Shen, TC (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM tshen@umd.edu FU U.S. Army Research Office (ARO); ARO [W911NF-13-1-0003] FX Work at the University of Maryland was supported by a grant from the U.S. Army Research Office (ARO). The third author acknowledges support by ARO under grant number W911NF-13-1-0003. NR 32 TC 6 Z9 6 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 5 PY 2014 VL 22 IS 9 BP 11107 EP 11118 DI 10.1364/OE.22.011107 PG 12 WC Optics SC Optics GA AH1TZ UT WOS:000335905300137 PM 24921809 ER PT J AU Hatch, S Wu, J Sablon, K Lam, P Tang, MC Jiang, Q Liu, HY AF Hatch, Sabina Wu, Jiang Sablon, Kimberly Phu Lam Tang, Mingchu Jiang, Qi Liu, Huiyun TI InAs/GaAsSb quantum dot solar cells SO OPTICS EXPRESS LA English DT Article ID GROWTH-TEMPERATURE; SPACER LAYER; EFFICIENCY; GAAS AB The hybrid structure of GaAs/GaAsSb quantum well (QW)/InAs quantum dots solar cells (QDSCs) is analyzed using power-dependent and temperature-dependent photoluminescence. We demonstrate that placing the GaAsSb QW beneath the QDs forms type-II characteristics that initiate at 12% Sb composition. Current density-voltage measurements demonstrate a decrease in power efficiency with increasing Sb composition. This could be attributed to increased valence band potential in the GaAsSb QW that subsequently limits hole transportation in the QD region. To reduce the confinement energy barrier, a 2 nm GaAs wall is inserted between GaAsSb QW and InAs QDs, leading to a 23% improvement in power efficiency for QDSCs. (C) 2014 Optical Society of America C1 [Hatch, Sabina; Wu, Jiang; Phu Lam; Tang, Mingchu; Jiang, Qi; Liu, Huiyun] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England. [Sablon, Kimberly] US Army Res Lab, Adelphi, MD 20783 USA. RP Hatch, S (reprint author), UCL, Dept Elect & Elect Engn, Torrington Pl, London WC1E 7JE, England. EM s.hatch@ucl.ac.uk RI Liu, Huiyun/H-5439-2011; Tang, Mingchu/K-1951-2015; Liu, Huiyun/I-4741-2016 OI Tang, Mingchu/0000-0001-6626-3389; FU EPSRC [EP/K029118/1]; US Army International Technology Center-Atlantic; Royal Society FX The authors acknowledge the financial support of EPSRC Grant EP/K029118/1 and US Army International Technology Center-Atlantic. H. Liu would like to thank The Royal Society for funding his University Research Fellowship. NR 22 TC 15 Z9 15 U1 2 U2 40 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 5 PY 2014 VL 22 IS 9 BP A679 EP A685 DI 10.1364/OE.22.00A679 PG 7 WC Optics SC Optics GA AH1TZ UT WOS:000335905300011 PM 24922376 ER PT J AU Caretti, DM Barker, DJ AF Caretti, David M. Barker, Daniel J. TI Effects of Respirator Ambient Air Cooling on Thermophysiological Responses and Comfort Sensations SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE full-facepiece respirator; ambient cooling; comfort; thermal sensation ID PROTECTIVE DEVICES; EXERCISE PERFORMANCE; RATING-SCALE; INTERMITTENT; HYPERTHERMIA; WORK; HUMANS; REST; PAIN AB This investigation assessed the thermophysiological and subjective impacts of different respirator ambient air cooling options while wearing chemical and biological personal protective equipment in a warm environment (32.7 +/- 0.4 degrees C, 49.6 +/- 6.5% RH). Ten volunteers participated in 90-min heat exposure trials with and without respirator (Control) wear and performed computer-generated tasks while seated. Ambient air cooling was provided to respirators modified to blow air to the forehead (FHC) or to the forehead and the breathing zone (BZC) of a full-facepiece air-purifying respirator using a low-flow (45 Lmin(-1)) mini-blower. An unmodified respirator (APR) trial was also completed. The highest body temperatures (T-TY) and least favorable comfort ratings were observed for the APR condition. With ambient cooling over the last 60min of heat exposure, T-TY averaged 37.4 +/- 0.6 degrees C for Control, 38.0 +/- 0.4 degrees C for APR, 37.8 +/- 0.5 degrees C for FHC, and 37.6 +/- 0.7 degrees C for BZC conditions independent of time. Both the FHC and BZC ambient air cooling conditions reduced facial skin temperatures, reduced the rise in body temperatures, and led to more favorable subjective comfort and thermal sensation ratings over time compared to the APR condition; however statistical differences among conditions were inconsistent. Independent of exposure time, average breathing apparatus comfort scores with BZC (7.2 +/- 2.5) were significantly different from both Control (8.9 +/- 1.4) and APR (6.5 +/- 2.2) conditions when ambient cooling was activated. These findings suggest that low-flow ambient air cooling of the face under low work rate conditions and mild hyperthermia may be a practical method to minimize the thermophysiological strain and reduce perceived respirator discomfort. C1 [Caretti, David M.; Barker, Daniel J.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Caretti, DM (reprint author), US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM david.m.caretti.civ@mail.mil NR 27 TC 0 Z9 0 U1 2 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAY 4 PY 2014 VL 11 IS 5 BP 269 EP 281 DI 10.1080/15459624.2013.858819 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AE8QG UT WOS:000334265800004 PM 24730706 ER PT J AU Kumar, R Kukreja, RV Li, L Zhmurov, A Kononova, O Cai, SW Ahmed, SA Barsegov, V Singh, BR AF Kumar, Raj Kukreja, Roshan V. Li, Li Zhmurov, Artem Kononova, Olga Cai, Shuowei Ahmed, Syed A. Barsegov, Valeri Singh, Bal Ram TI Botulinum neurotoxin: unique folding of enzyme domain of the most-poisonous poison SO JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS LA English DT Article DE MD simulations; protein folding; urea denaturation; botulinum neurotoxin ID MOLTEN GLOBULE STATE; MOLECULAR-DYNAMICS; ENDOPEPTIDASE ACTIVITY; PROTEIN DENATURATION; LIGHT-CHAIN; STABILITY; TOXIN; UREA; FEATURES; SEROTYPE AB Botulinum neurotoxin (BoNT), the most toxic substance known to mankind, is the first example of the fully active molten globule state. To understand its folding mechanism, we performed urea denaturation experiments and theoretical modeling using BoNT serotype A (BoNT/A). We found that the extent of BoNT/A denaturation from the native state (N) shows a nonmonotonic dependence on urea concentration indicating a unique multistep denaturation process, N -> I-1 I-2 U, with two intermediate states I-1 and I-2. BoNT/A loses almost all its secondary structure in 3.75 M urea (I-1), yet it displays a native-like secondary structure in 5 M urea (I-2). This agrees with the results of theoretical modeling, which helped to determine the molecular basis of unique behavior of BoNT/A in solution. Except for I-2, all the states revert back to full enzymatic activity for SNAP-25 including the unfolded state U stable in 7 M urea. Our results stress the importance of structural flexibility in the toxin's mechanism of survival and action, an unmatched evolutionary trait from billion-year-old bacteria, which also correlates with the long-lasting enzymatic activity of BoNT inside neuronal cells. BoNT/A provides a rich model to explore protein folding in relation to functional activity. C1 [Kumar, Raj; Kukreja, Roshan V.; Li, Li; Cai, Shuowei; Singh, Bal Ram] Univ Massachusetts, Botulinum Res Ctr, Dept Chem & Biochem, Dartmouth, MA 02747 USA. [Ahmed, Syed A.] US Army Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. [Zhmurov, Artem; Kononova, Olga; Barsegov, Valeri] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. RP Barsegov, V (reprint author), Univ Massachusetts, Dept Chem, 1 Univ Ave, Lowell, MA 01854 USA. EM Valeri_Barsegov@uml.edu; bsingh@umassd.edu RI Zhmurov, Artem/F-4455-2012; Barsegov, Valeri/A-6203-2014; Kononova, Olga/C-8698-2014 OI Zhmurov, Artem/0000-0002-4414-8352; FU US Army Medical Research Activity [USAMRAA-W81XWH-08-P-0705]; National Institutes of Health [1U01A1078070-01] FX The work was supported in part by US Army Medical Research Activity (Grant USAMRAA-W81XWH-08-P-0705 to B.R.S), and National Institutes of Health (Grant 1U01A1078070-01 to B.R.S). We would like to thank Mr Stephen Riding for preparing protein samples. We would like to thank the anonymous reviewer whose comments have helped us to improve the quality of the paper. NR 38 TC 2 Z9 2 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0739-1102 EI 1538-0254 J9 J BIOMOL STRUCT DYN JI J. Biomol. Struct. Dyn. PD MAY 4 PY 2014 VL 32 IS 5 BP 804 EP 815 DI 10.1080/07391102.2013.791878 PG 12 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AB1BA UT WOS:000331525100011 PM 23746226 ER PT J AU Chacho, TM AF Chacho, Tania M. TI Potential Partners in the Pacific? Mutual interests and the Sino-NATO relationship SO JOURNAL OF CONTEMPORARY CHINA LA English DT Article AB Is there mutual benefit in a relationship between the People's Republic of China and the North Atlantic Treaty Alliance (NATO)? At first glance, China and NATO appear to have little to offer one another, and many obstacles to cooperation exist. But distinct (and different) benefits exist for both parties should they elect to pursue a relationship based on interests. NATO and China share a common interest in maintaining international security, and increased interaction can thus appeal to NATO's desire to extend cooperative security beyond the Euro-Atlantic area while offering the Chinese a means for protecting their interests on the global stage in a constructive, non-threatening manner. While both NATO and China have interests in Afghanistan, the most fertile ground for a future relationship lies in mutual interests in four 'politically acceptable' domains: crisis management, humanitarian assistance/disaster relief, counter-proliferation and counter-piracy. Increased interaction will present both NATO and China with risks, but these are ultimately outweighed by the potential benefits. C1 US Mil Acad, Dept Social Sci, Comparat Polit program, West Point, NY 10996 USA. RP Chacho, TM (reprint author), US Mil Acad, Dept Social Sci, Comparat Polit program, West Point, NY 10996 USA. EM tania.chacho@usma.edu NR 62 TC 0 Z9 0 U1 0 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1067-0564 EI 1469-9400 J9 J CONTEMP CHINA JI J. Contemp. China PD MAY 4 PY 2014 VL 23 IS 87 BP 387 EP 407 DI 10.1080/10670564.2013.843879 PG 21 WC Area Studies SC Area Studies GA AE3OU UT WOS:000333886600001 ER PT J AU Knapik, JJ Steelman, RA Hoedebecke, SS Farina, EK Austin, KG Lieberman, HR AF Knapik, Joseph J. Steelman, Ryan A. Hoedebecke, Sally S. Farina, Emily K. Austin, Krista G. Lieberman, Harris R. TI A systematic review and meta-analysis on the prevalence of dietary supplement use by military personnel SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article DE Vitamins; Minerals; Multivitamins; Vitamin C; Vitamin E; Calcium; Iron; Protein; Creatine; Sport drink ID HEALTH INTERVIEW SURVEY; UNITED-STATES; ENERGY DRINKS; NATIONAL-HEALTH; CREATINE SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; MINERAL SUPPLEMENTS; ARMY SOLDIERS; MULTIMINERAL SUPPLEMENTATION; NUTRITIONAL SUPPLEMENTS AB Background: Although a number of studies have been conducted on the prevalence of dietary supplement (DS) use in military personnel, these investigations have not been previously summarized. This article provides a systematic literature review of this topic. Methods: Literature databases, reference lists, and other sources were searched to find studies that quantitatively examined the prevalence of DS use in uniformed military groups. Prevalence data were summarized by gender and military service. Where there were at least two investigations, meta-analysis was performed using a random model and homogeneity of the prevalence values was assessed. Results: The prevalence of any DS use for Army, Navy, Air Force, and Marine Corps men was 55%, 60%, 60%, and 61%, respectively; for women corresponding values were 65%, 71%, 76%, and 71%, respectively. Prevalence of multivitamin and/or multimineral (MVM) use for Army, Navy, Air Force, and Marine Corps men was 32%, 46%, 47%, and 41%, respectively; for women corresponding values were 40%, 55%, 63%, and 53%, respectively. Use prevalence of any individual vitamin or mineral supplement for Army, Navy, Air Force, and Marine Corps men was 18%, 27%, 25%, and 24%, respectively; for women corresponding values were 29%, 36%, 40%, and 33%, respectively. Men in elite military groups (Navy Special Operations, Army Rangers, and Army Special Forces) had a use prevalence of 76% for any DS and 37% for MVM, although individual studies were not homogenous. Among Army men, Army women, and elite military men, use prevalence of Vitamin C was 15% for all three groups; for Vitamin E, use prevalence was 8%, 7%, and 9%, respectively; for sport drinks, use prevalence was 22%, 25% and 39%, respectively. Use prevalence of herbal supplements was generally low compared to vitamins, minerals, and sport drinks, <= 5% in most investigations. Conclusions: Compared to men, military women had a higher use prevalence of any DS and MVM. Army men and women tended to use DSs and MVM less than other service members. Elite military men appeared to use DSs and sport drinks more than other service members. C1 [Knapik, Joseph J.; Farina, Emily K.; Austin, Krista G.; Lieberman, Harris R.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Knapik, Joseph J.; Steelman, Ryan A.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Hoedebecke, Sally S.] Seren Hill Nutr, Bethesda, MD USA. [Knapik, Joseph J.; Steelman, Ryan A.; Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Knapik, Joseph J.] USARIEM, Natick, KS USA. RP Knapik, JJ (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. EM joseph.j.knapik.ctr@mail.mil FU US Army Research Institute of Environmental Medicine (USARIEM); Army Institute of Public Health (AIPH); Department of Defense Center; Medical Research and Development Command FX We would like to thank Claudia Coleman and Dr Wayne Askew who assisted us in obtaining references. This research was supported in part by an appointment to the Knowledge Preservation Program at the US Army Research Institute of Environmental Medicine (USARIEM) and the Army Institute of Public Health (AIPH) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARIEM. Funding was also provided by the Department of Defense Center for Dietary Supplement Research and the Medical Research and Development Command. NR 113 TC 13 Z9 14 U1 4 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6882 J9 BMC COMPLEM ALTERN M JI BMC Complement. Altern. Med. PD MAY 2 PY 2014 VL 14 AR 143 DI 10.1186/1472-6882-14-143 PG 19 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA AH3WV UT WOS:000336057800001 PM 24884570 ER PT J AU Kamnaksh, A Budde, MD Kovesdi, E Long, JB Frank, JA Agoston, DV AF Kamnaksh, Alaa Budde, Matthew D. Kovesdi, Erzsebet Long, Joseph B. Frank, Joseph A. Agoston, Denes V. TI Diffusion Tensor Imaging Reveals Acute Subcortical Changes after Mild Blast-Induced Traumatic Brain Injury SO SCIENTIFIC REPORTS LA English DT Article ID LONG-TERM CONSEQUENCES; AXONAL INJURY; MILITARY; CONCUSSION; BIOMARKERS; VETERANS; COMBAT; MODEL; RATS; MRI AB Mild blast-induced traumatic brain injury (mbTBI) poses special diagnostic challenges due to its overlapping symptomatology with other neuropsychiatric conditions and the lack of objective outcome measures. Diffusion tensor imaging (DTI) can potentially provide clinically relevant information toward a differential diagnosis. In this study, we aimed to determine if single and repeated (5 total; administered on consecutive days) mild blast overpressure exposure results in detectable structural changes in the brain, especially in the hippocampus. Fixed rat brains were analyzed by ex vivo DTI at 2 h and 42 days after blast (or sham) exposure(s). An anatomy-based region of interest analysis revealed significant interactions in axial and radial diffusivity in a number of subcortical structures at 2 h only. Differences between single-and multiple-injured rats were largely in the thalamus but not the hippocampus. Our findings demonstrate the value and the limitations of DTI in providing a better understanding of mbTBI pathobiology. C1 [Kamnaksh, Alaa; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Kamnaksh, Alaa] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Budde, Matthew D.; Frank, Joseph A.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA. [Kovesdi, Erzsebet] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC 20420 USA. [Long, Joseph B.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Agoston, DV (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM denes.agoston@usuhs.edu FU Center for Neuroscience and Regenerative Medicine [G1703F] FX We thank the Neurotrauma Team at the Walter Reed Army Institute of Research for their technical help during the exposures, along with Eric Gold and Lindsay Janes for assistance with the MRI experiments. This work was supported by the Center for Neuroscience and Regenerative Medicine grant number G1703F. NR 59 TC 6 Z9 7 U1 2 U2 12 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAY 2 PY 2014 VL 4 AR 4809 DI 10.1038/srep04809 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AG1ZZ UT WOS:000335216000001 PM 24786839 ER PT J AU Cochet, AA Lucero, PF Zacher, LL Morris, MJ AF Cochet, Anthony A. Lucero, Pedro F. Zacher, Lisa L. Morris, Michael J. TI Prevalence of Supranormal Pulmonary Function Test Values Between a Military and Nonmilitary Cohort SO RESPIRATORY CARE LA English DT Article DE pulmonary junction testing; military personnel; supranormal values ID LUNG-FUNCTION; RESPIRATORY MUSCLE; EXERCISE; SWIMMERS; PERFORMANCE; ASTHMA AB BACKGROUND: The study objective was to determine differences in the proportion of supranormal pulmonary function tests (PFTs) between active duty (AD) military personnel and a similar non-active duty (non-AD) population. Given the emphasis on cardiovascular fitness in the military, it has been hypothesized that regular exercise in this cohort leads to an increased proportion of supranormal PFTs. We hypothesized that a comparison of PFTs would identify no differences in the ratio of supranormal to normal PFTs between the AD and non-AD populations. METHODS: A retrospective chart review was conducted of all PFT studies at the Brooke Army Medical Center from 2006 to 2011. Studies were included with either an FVC or FEV1 > 110% of predicted, with both values > 100% of predicted. A comparative analysis was performed for patients between 18 and 50 years of age based on AD status. Further analysis was performed on all ages to determine the distribution of supranormal findings in the entire study population. RESULTS: A total of 16,600 interpreted PFTs were queried. Of those, 4.303 (31.6%) were AD patients, and 9,306 (68.4%) were non-AD patients. From all of the PFTs reviewed, a total of 912 (6.7%) were identified as supranormal. When further analyzed, 381 (9.4%) of AD patients 18-50 years old were supranormal, 175 (12.4%) of non-AD patients 18-50 years old were supranormal, and 356 (4.7%) of non-AD patients older than 50 years were supranormal. CONCLUSIONS: This study revealed no significant difference in the proportion of supranormal-to-normal PFTs in an AD versus non-AD duty population of the same age range. Based on these findings, no assumption should be made that supranormal PFTs are more common in military personnel. Interpretation of normal PFTs in AD personnel undergoing evaluation should not differ from that in any typical patient. C1 [Cochet, Anthony A.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Lucero, Pedro F.; Zacher, Lisa L.; Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Sam Houston, TX 78234 USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Pulm Crit Care Serv MCHE MDP, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.j.morris34.civ@mail.mil FU Pfizer/Boehringer Ingelheim FX Dr. Morris is a paid speaker for Spiriva by Pfizer/Boehringer Ingelheim. The other authors have declared no conflicts of interest. NR 21 TC 1 Z9 1 U1 2 U2 2 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 EI 1943-3654 J9 RESP CARE JI Respir. Care PD MAY PY 2014 VL 59 IS 5 BP 749 EP 755 DI 10.4187/respcare.02112 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA8VS UT WOS:000349199600016 PM 24046463 ER PT J AU Howard, IL Doyle, JD AF Howard, Isaac L. Doyle, Jesse D. TI Investigating the Consistency of Asphalt Density Measurement Methods Over a Wide Range of Air Voids SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE Asphalt Mixture; Flexible Pavements; Bulk Density; Bulk Specific Gravity; Air Voids ID BULK SPECIFIC-GRAVITY; CONCRETE; MIXTURES AB The overall purpose of this paper is to identify the most reliable bulk mixture specific gravity (G(mb)) measurement method for dense graded asphalt concrete that can be used for a wide range of air voids and specimen types. A secondary purpose is to identify ranges of conditions where less established G(mb) measurement methods are suitable. A comprehensive literature review was performed to identify promising density test methods for further study. Findings from studies comparing AASHTO T166 (saturated surface dry method) and AASHTO T331 (Corelok method) were used to provide a succinct summary of the relative behaviors of the two methods at mix design, performance testing, and field construction air void levels. Density measurement was performed using four methods (AASHTO T166, T269, T331, and TP82) on dense graded mixture specimens. In total, approximately 2500 data points were used herein, with approximately 30 % of this total coming from literature review and 70 % coming from the authors of this paper. Review of literature along with the evidence presented in this paper indicates that T331 is the most reasonably accurate and versatile G(mb) measurement method for a wide range of air voids all the way from mix design through performance testing to construction acceptance testing. T331 has also been recommended (or at least evaluated favorably) by several previous researchers over the last ten years. Based on the evidence presented in this paper, the provisional TP82 test method in its current form does not provide acceptable G(mb) measurements relative to T166 or T331 over a wide range of air voids. The magnitude of the discrepancy begins to increase dramatically as air voids increase. C1 [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, Mississippi State, MS 39762 USA. [Doyle, Jesse D.] US Army, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. RP Doyle, JD (reprint author), US Army, Corps Engineers, Engn Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ilhoward@cee.msstate.edu; jesse.d.doyle@erdc.dren.mil FU Mississippi DOT; Southeast Region Research Initiative FX The Mississippi DOT and Southeast Region Research Initiative funded studies where portions of the data used were collected. Jim Bibler, Technical Development Manager of Gilson Company, Inc. and Mark Kuss, President/CEO of Challenge Technology, provided technical assistance for the TP82 equipment. Permission to publish this paper was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 36 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD MAY PY 2014 VL 42 IS 3 BP 749 EP 760 DI 10.1520/JTE20130157 PG 12 WC Materials Science, Characterization & Testing SC Materials Science GA AU5JU UT WOS:000345643800023 ER PT J AU Rinehart, RV Pabst, MW AF Rinehart, Robert V. Pabst, Mark W. TI A New Test for Cementation Potential of Embankment Dam Granular Filter Material SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE embankment dam; granular filter material; cohesion; cementation; cracking; modified sand castle test; internal erosion ID SOILS AB Granular filters are used in embankment dams to protect against uncontrolled flow and internal erosion either through the embankment or the foundation. For proper performance, the filter material must not be able to sustain a crack even if the core material becomes cracked itself. Historically, the mechanism used to limit cracking potential is a restriction of no more than 5 % nonplastic fines. It has been recognized though that this requirement has not been effective in identifying cracking potential for all materials. Since the requirement is related to the exclusion of clay and silt size particles (i.e., fines) it appears to not always identify other minerals that can act as cementing agents. A supplemental test known as the Sand Castle Test was also developed, and although it did not specifically focus on detecting other binding agents it was thought to hold promise. However, since the original test lacked a precise procedure and sensitivity to some binding agents, a modification of the Sand Castle Test is being undertaken. This paper outlines the need for a new test and describes specimen preparation, Modified Sand Castle Test procedures, and results from 16 source materials from across the United States. A petrographic examination was carried out to investigate the cementing mechanisms in selected materials. Additionally, unconfined compression tests were performed on each material to help quantify the strength from cementation. The sand equivalency value was also determined for all materials to see how well it correlated with the Modified Sand Castle Test results. The Modified Sand Castle Test is shown to be a good indicator of cementation potential and correlates well with unconfined compressive strength, but to a lesser degree with sand equivalency value. C1 [Rinehart, Robert V.] US Bur Reclamat, Tech Serv Ctr, Denver, CO 80225 USA. [Pabst, Mark W.] US Army Corps Engineers, Risk Management Ctr, Lakewood, CO 80228 USA. RP Rinehart, RV (reprint author), US Bur Reclamat, Tech Serv Ctr, POB 25007, Denver, CO 80225 USA. EM rrinehart@usbr.gov; mark.w.pabst@usace.army.mil FU US Army Corps of Engineers Risk Management Center; Bureau of Reclamation Dam Safety Office Technology Development Program FX The writers are grateful for financial assistance provided by the US Army Corps of Engineers Risk Management Center, and the Bureau of Reclamation Dam Safety Office Technology Development Program. The contributions to the testing program made by Bethany Jackson, Khadija Ngozi-Bullock, Doug Hurcomb, and Kristi Evans of the U.S. Bureau of Reclamation are gratefully acknowledged. NR 31 TC 0 Z9 0 U1 1 U2 9 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0149-6115 EI 1945-7545 J9 GEOTECH TEST J JI Geotech. Test. J. PD MAY PY 2014 VL 37 IS 3 DI 10.1520/GTJ20130150 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA AS3IP UT WOS:000344171100015 ER PT J AU White, LA Rumsey, MG Mullins, HM Nye, CD LaPort, KA AF White, Leonard A. Rumsey, Michael G. Mullins, Heather M. Nye, Christopher D. LaPort, Kate A. TI Toward a New Attrition Screening Paradigm: Latest Army Advances SO MILITARY PSYCHOLOGY LA English DT Article DE selection; attrition; adaptability screening; turnover; personality; ASVAB ID PERSONALITY MEASURES; RESPONSE DISTORTION; JOB-PERFORMANCE; PREDICTORS; SETTINGS; IMPACT AB Managing and reducing attrition during the first term of enlistment is a continuing priority for the services. Over the past decade, attrition rates in the Army have averaged between 25% and 30% during first-term periods of enlistment. Historically, the services have relied on education credentials, with special emphasis on possessing a high school diploma, as a primary indicator of completion rates after enlistment and as a proxy for the ability to adapt to a military lifestyle. A primary purpose of this paper is to describe Army research to develop new indicators of adaptability to augment the current system based on education credentials. This work has focused primarily on noncognitive, personality measures and how such measures can be combined with other existing measures for attrition screening during enlistment processing. These advances represent a new paradigm that relies less heavily on education credentials and can provide a more comprehensive and inclusive approach. This new approach incorporates advances in testing methodology to make it more viable for use in large-scale, high-stakes testing applications. C1 [White, Leonard A.; Mullins, Heather M.; LaPort, Kate A.] US Army Res Inst, Ft Belvoir, VA USA. [Nye, Christopher D.] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA. RP White, LA (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St,Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22060 USA. EM leonard.a.white4.civ@mail.mil NR 65 TC 3 Z9 3 U1 1 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD MAY PY 2014 VL 26 IS 3 SI SI BP 138 EP 152 DI 10.1037/mil0000047 PG 15 WC Psychology, Multidisciplinary SC Psychology GA AQ0WV UT WOS:000342504300002 ER PT J AU Stark, S Chernyshenko, OS Drasgow, F Nye, CD White, LA Heffner, T Farmer, WL AF Stark, Stephen Chernyshenko, Oleksandr S. Drasgow, Fritz Nye, Christopher D. White, Leonard A. Heffner, Tonia Farmer, William L. TI From ABLE to TAPAS: A New Generation of Personality Tests to Support Military Selection and Classification Decisions SO MILITARY PSYCHOLOGY LA English DT Article DE computerized adaptive testing; forced choice; ideal point; narrow factors; personality ID ITEM SCORE PATTERNS; JOB-PERFORMANCE; CONTEXTUAL PERFORMANCE; SOCIAL DESIRABILITY; PERSONNEL-SELECTION; PAIRWISE-PREFERENCE; ADVERSE IMPACT; FAKING; METAANALYSIS; VALIDITY AB This article discusses 3 modern forced-choice personality tests developed for the U.S Armed Services to provide resistance to faking and other forms of response distortion: the Assessment of Individual Motivation, the Navy Computerized Adaptive Personality Scales, and the Tailored Adaptive Personality Assessment System. These tests represent the transition from Likert to forced-choice formats and from static to computerized adaptive item selection to meet the challenges of large-scale, high-stakes testing environments. For each test, we briefly describe the personality constructs that are assessed, the response format and scoring methods, and selected ongoing research and development efforts. We also highlight the potential of these tests for personnel selection, classification, and diagnostic screening purposes. C1 [Stark, Stephen] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Chernyshenko, Oleksandr S.] Nanyang Technol Univ, Dept Strategy Management & Org, Singapore, Singapore. [Drasgow, Fritz] Univ Illinois, Dept Psychol, Urbana, IL USA. [Nye, Christopher D.] Bowling Green State Univ, Dept Psychol, Bowling Green, OH 43403 USA. [White, Leonard A.; Heffner, Tonia] Army Res Inst, Ft Belvoir, VA USA. [Farmer, William L.] Navy Personnel Res Studies & Technol, Millington, TN USA. RP Stark, S (reprint author), Univ S Florida, Dept Psychol, PCD 4118G, Tampa, FL 33620 USA. EM sestark@usf.edu NR 59 TC 9 Z9 9 U1 2 U2 14 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD MAY PY 2014 VL 26 IS 3 SI SI BP 153 EP 164 DI 10.1037/mil0000044 PG 12 WC Psychology, Multidisciplinary SC Psychology GA AQ0WV UT WOS:000342504300003 ER PT J AU Jeffries, M Overland, J Perovich, D AF Jeffries, Martin Overland, James Perovich, Don TI Weighing in on the cost of research papers Reply SO PHYSICS TODAY LA English DT Letter C1 [Jeffries, Martin] US Arctic Res Commiss, Arlington, VA 22203 USA. [Overland, James] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA. [Perovich, Don] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Jeffries, M (reprint author), US Arctic Res Commiss, Arlington, VA 22203 USA. EM martin.jeffries@navy.mil; james.e.overland@noaa.gov; donald.k.perovich@usace.army.mil NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 EI 1945-0699 J9 PHYS TODAY JI Phys. Today PD MAY PY 2014 VL 67 IS 5 BP 9 EP 9 PG 1 WC Physics, Multidisciplinary SC Physics GA AO6FV UT WOS:000341446300008 ER PT J AU Mabry, RL DeLorenzo, R AF Mabry, Robert L. DeLorenzo, Robert TI Challenges to Improving Combat Casualty Survival on the Battlefield SO MILITARY MEDICINE LA English DT Editorial Material ID CURRENT WAR; CARE; DEATH C1 [Mabry, Robert L.] San Antonio Mil Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [DeLorenzo, Robert] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Mabry, RL (reprint author), San Antonio Mil Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 13 TC 3 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2014 VL 179 IS 5 BP 477 EP 482 DI 10.7205/MILMED-D-13-00417 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UL UT WOS:000340806400004 PM 24806491 ER PT J AU Abraham, JH Clark, LL Hu, Z Baird, CP DeFraites, R Tobler, SK Richards, EE Sharkey, JM Lipnick, RJ Ludwig, SL AF Abraham, Joseph H. Clark, Leslie L. Hu, Zheng Baird, Coleen P. DeFraites, Robert Tobler, Steven K. Richards, Erin E. Sharkey, Jessica M. Lipnick, Robert J. Ludwig, Sharon L. TI A Retrospective Cohort Study of Military Deployment and Postdeployment Medical Encounters for Respiratory Conditions SO MILITARY MEDICINE LA English DT Article ID PARTICULATE MATTER; LUNG-DISEASE; HEALTH; AFGHANISTAN; PERSONNEL; SYMPTOMS; IRAQ; EXPOSURE; SOLDIERS; BIAS AB Deployed military personnel are exposed to inhalational hazards that may increase their risk of chronic lung conditions. This evaluation assessed associations between Operation Iraqi Freedom (OIF) deployment and post-deployment medical encounters for respiratory symptoms and medical conditions. This retrospective cohort study was conducted among military personnel who, between January 2005 and June 2007, were deployed to either of two locations with burn pits in Iraq, or to either of two locations without burn pits in Kuwait. Incidence rate ratios (IRRs) were estimated using two nondeployed reference groups. Rates among personnel deployed to burn pit locations were also compared directly to those among personnel deployed to locations without burn pits. Significantly elevated rates of encounters for respiratory symptoms (IRR = 1.25; 95% confidence interval [CI]: 1.20-1.30) and asthma (IRR = 1.54; 95% CI: 1.33-1.78) were observed among the formerly deployed personnel relative to U.S.-stationed personnel. Personnel deployed to burn pit locations did not have significantly elevated rates for any of the outcomes relative to personnel deployed to locations without burn pits. These results are consistent with the hypothesis that OIF deployment is associated with subsequent risk of respiratory conditions. Elevated medical encounter rates were not uniquely associated with burn pits. C1 [Abraham, Joseph H.; Baird, Coleen P.; Sharkey, Jessica M.] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Clark, Leslie L.; Hu, Zheng; Tobler, Steven K.; Richards, Erin E.; Lipnick, Robert J.; Ludwig, Sharon L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [DeFraites, Robert] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Abraham, JH (reprint author), US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 28 TC 15 Z9 15 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2014 VL 179 IS 5 BP 540 EP 546 DI 10.7205/MILMED-D-13-00443 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UL UT WOS:000340806400012 PM 24806499 ER PT J AU Devlin, JD Knapik, JJ Solomon, Z Hauret, KG Morris, K Carter, R McGill, R Paoli, L AF Devlin, Jevettra D. Knapik, Joseph J. Solomon, Zack Hauret, Keith G. Morris, Krystal Carter, Robert McGill, Ryan Paoli, Latondra TI Incidence of Admission to the Physical Training and Rehabilitation Programs in Initial Entry Training During Fiscal Year 2011 SO MILITARY MEDICINE LA English DT Article ID NECK STRESS-FRACTURES; RISK-FACTORS; INJURY INCIDENCE; ARMY RECRUITS; MILITARY; OUTCOMES; FITNESS; GENDER; TRAINEES; MEN AB The Physical Training and Rehabilitation Program (PTRP) is a recovery and reintegration program for recruits in Initial Entry Training (IET) who are unable to continue training because of serious injury. This investigation examined PTRP admission incidence among recruits in IET at Forts Jackson, Leonard Wood, Benning, and Sill during Fiscal Year 2011 (FY11). PTRP admission data were collected from a spreadsheet completed monthly by PTRP commanders. Total number of recruits was obtained from each post's Directorate of Programs, Training, and Management. In FY11, 368 men and 268 women were admitted into PTRPs at all installations. For Forts Jackson, Leonard Wood, Benning, and Sill, male admission incidences (cases/1,000 recruits) were 2.6, 3.0, 6.2, and 5.4, respectively; female admission incidences for Forts Jackson, Leonard Wood, and Sill, were 11.1, 10.1, and 22.6, respectively. Most injuries sent to PTRP were bone stress injuries (65%) or fractures (21%). 76% of recruits were returned to duty. Differences in admission incidence between posts appear primarily related to different local policies regarding convalescent leave and admission criteria. PTRP admission rates are lower than in the past, presumably related to policy changes and injury-reduction efforts. A cost-benefit analysis would assist in determining the value of the PTRP. C1 [Devlin, Jevettra D.] White Owl Solut, Epidemiol Data Ctr, Navy & Marine Corps Publ Hlth Ctr, Portsmouth, VA 23704 USA. [Knapik, Joseph J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Knapik, Joseph J.; Solomon, Zack; Hauret, Keith G.] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Morris, Krystal] Phys Therapy & Rehabil Program, Ft Benning, GA 31905 USA. [Carter, Robert] Fitness Training Co, Jackson, SC 29207 USA. [McGill, Ryan] Phys Therapy & Rehabil Program, Fort Leonard Wood, MO 65473 USA. [Paoli, Latondra] Phys Therapy & Rehabil Program, Fort Sill, OK 73505 USA. RP Devlin, JD (reprint author), White Owl Solut, Epidemiol Data Ctr, Navy & Marine Corps Publ Hlth Ctr, 620 John Paul Jones Circle, Portsmouth, VA 23704 USA. FU U.S. Army Public Health Command FX This project was supported in part by an appointment to the Research Participation Program for the U.S. Army Public Health Command administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the U.S. Army Public Health Command. NR 32 TC 1 Z9 1 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2014 VL 179 IS 5 BP 547 EP 552 DI 10.7205/MILMED-D-13-00361 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UL UT WOS:000340806400013 PM 24806500 ER PT J AU Donean, K Romano, C DesRoches, C Applebaum, S Ward, JRM Schoneboom, BA Hinshaw, AS AF Donean, Karen Romano, Carol DesRoches, Catherine Applebaum, Sandra Ward, Johanna R. M. Schoneboom, Bruce A. Hinshaw, Ada Sue TI National Surveys of Military Personnel, Nursing Students, and the Public: Drivers of Military Nursing Careers SO MILITARY MEDICINE LA English DT Article ID NURSES AB Objectives: The U.S. health care system is facing a projected nursing shortage of unprecedented magnitude. Although military nursing services recently have been able to meet their nursing recruitment quotas, national studies have predicted a long-term nursing shortage that may affect future recruitment for the Nurse Corps of the three military services. Data are needed to plan for recruitment incentives and the impact of those incentives on targeted populations of likely future nurses. Methods: Data are drawn from three online surveys conducted in 2011-2012, including surveys of 1,302 Army, Navy, and Air Force personnel serving on major military bases, 914 nursing students at colleges with entry Bachelor of Science in Nursing programs located nearby major military bases, and a qualitative survey of 1,200 young adults, age 18-39, in the general public. Findings: The three populations are different in several demographic characteristics. We explored perceptions of military careers, nursing careers and barriers, and incentives to pursue military nursing careers in all populations. Perceptions differ among the groups. Conclusion: The results of this study may help to inform strategies for reaching out to specific populations with targeted messages that focus on barriers and facilitators relevant to each to successfully recruit a diverse Nurse Corps for the future. C1 [Donean, Karen] Massachusetts Gen Hosp, Mongan Inst Hlth Policy, Boston, MA 02114 USA. [Romano, Carol; Hinshaw, Ada Sue] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. [DesRoches, Catherine] Math Policy Res, Cambridge, MA 02139 USA. [Applebaum, Sandra] Harris Interact Inc, New York, NY 10010 USA. [Ward, Johanna R. M.] Math Policy Res, Princeton, NJ 08543 USA. [Schoneboom, Bruce A.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Donean, K (reprint author), Massachusetts Gen Hosp, Mongan Inst Hlth Policy, 50 Staniford St,9th floor, Boston, MA 02114 USA. FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [HU0001-05-D-0005, 0051] FX Funding for this project is from the Department of Defense's TRICARE Management Activity through a subcontract to Massachusetts General Hospital from The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc HU0001-05-D-0005 Task Order 0051. NR 15 TC 2 Z9 2 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2014 VL 179 IS 5 BP 565 EP 572 DI 10.7205/MILMED-D-13-00323 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UL UT WOS:000340806400016 PM 24806503 ER PT J AU Singh, VP Cui, H Byrd, AR AF Singh, V. P. Cui, H. Byrd, A. R. TI TSALLIS ENTROPY-BASED FLOW DURATION CURVE SO TRANSACTIONS OF THE ASABE LA English DT Article DE Duration curve; Entropy; Flow duration curve; Lagrange multipliers; Principle of maximum entropy; Tsallis entropy ID VELOCITY DISTRIBUTION; OPEN CHANNELS AB The flow duration curve (FDC) is employed for addressing a multitude of problems in water resources engineering, such as prediction of the distribution of future flows, forecasting of future recurrence frequencies, comparison of watersheds, construction of load duration curves, and determination of low flow thresholds. Usually, the FDC is constructed empirically for a given set of flow data, and the FDC so constructed is found to vary from one year to another and from one gauging station to another within the same watershed This article attempts to analytically derive the FDC by maximizing the Tsallis entropy based on the knowledge that the mean discharge is known, thus obviating the need for any fitting. The mean discharge is found to be strongly related to the drainage area. The Tsallis entropy-based FDC is tested using field data and is found to be in agreement with the observed curve. The entropy method permits a probabilistic characterization of the FDC and hence a quantitative assessment of its uncertainty. With this method, the flow duration curve can also be forecasted for different recurrence intervals. The entropy is found to monotonically increase with the increase in time interval, indicating that the flow system becomes more complex but the degree of complexity decreases with increasing time interval after a certain time, eventually reaching a constant value, reflecting a reduced influence of land use change and other human influences on the flow regime. C1 [Singh, V. P.] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA. [Singh, V. P.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Cui, H.] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. [Byrd, A. R.] US Army Corps Engineers Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Byrd, A. R.] US Army Corps Engineers Engn Res & Dev Ctr, Coastal & Hydraul Lab, Hydrol Syst Branch, Vicksburg, MS USA. RP Singh, VP (reprint author), Texas A&M Univ, 321 Scoates Hall, College Stn, TX 77843 USA. EM vsingh@tamu.edu NR 24 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 2151-0032 EI 2151-0040 J9 T ASABE JI Trans. ASABE PD MAY-JUN PY 2014 VL 57 IS 3 BP 837 EP 849 PG 13 WC Agricultural Engineering SC Agriculture GA AM7XK UT WOS:000340081800013 ER PT J AU Park, B Windham, WR Ladely, SR Gurram, P Kwon, H Yoon, SC Lawrence, KC Narang, N Cray, WC AF Park, B. Windham, W. R. Ladely, S. R. Gurram, P. Kwon, H. Yoon, S. C. Lawrence, K. C. Narang, N. Cray, W. C. TI DETECTION OF NON-O157 SHIGA TOXIN-PRODUCING ESCHERICHIA COLI (STEC) SEROGROUPS WITH HYPERSPECTRAL MICROSCOPE IMAGING TECHNOLOGY SO TRANSACTIONS OF THE ASABE LA English DT Article DE Acousto-optic tunable filter; Bacteria; Dark-field illumination; Escherichia coli; Foodborne pathogen; Hyperspectral; Microscopy; STEC ID OUTBREAKS; SAFETY; SYSTEM; SKIN AB Non-O157 Shiga toxin-producing Escherichia coli (STEC) serogroups such as 026, 045, 0103, 0111, 0121, and 0145 are recognized as serious risks to human health due to their toxicity. The conventional microbiological detection method of cell counting on agar plates is laborious and time-consuming. Because optical methods are promising for real-time, in situ foodborne pathogen detection, a hyperspectral microscope imaging (HMI) method based on acousto-optic tunable filters (AOTF) was developed for detecting pathogenic bacteria with a capability to differentiate the spectral characteristics of each bacterial cell from microcolony samples. Using the AOTF-based HMI method, a total of 89 contiguous spectral images were acquired within approximately 45 s with 250 ms exposure time. In this study, we developed a protocol for successfully immobilizing live cells on glass slides to acquire quality spectral images of STEC bacterial cells using a modified drying method. Among the contiguous spectral imagery between 450 and 800 nm, the intensities at 458, 498, 522, 546, 570, 586, 670, and 690 nm were distinct for STEC bacteria under dark-field illumination. With two different classification algorithms, i.e., support vector machine (SVM) and sparse kernel-based ensemble learning (SKEL), STEC serogroup 045 could be classified with 92% detection accuracy. However, the mean accuracies in identifying the six STEC serogroups with SVM and SKEL were not high enough for use in classification models. C1 [Park, B.; Windham, W. R.; Yoon, S. C.; Lawrence, K. C.] USDA ARS, Russell Res Ctr, Athens, GA 30613 USA. [Ladely, S. R.; Narang, N.; Cray, W. C.] USDA FSIS Eastern Lab, Athens, GA USA. [Gurram, P.; Kwon, H.] US Army Res Lab, Adelphi, MD USA. RP Park, B (reprint author), Russell Res Ctr, 950 Coll Stn Rd, Athens, GA 30604 USA. EM bosoon.park@ars.usda.gov FU National Institute for Hometown Security, Somerset, Kentucky FX The authors would like to thank Dr. Nasreen Bano, Jerrie Barnett, Gerald Heitschmidt, and Peggy Feldner of the USDA-ARS Quality and Safety Assessment Research Unit in Athens, Georgia, for their assistance in this research. This project is partially supported by the National Institute for Hometown Security, Somerset, Kentucky. NR 28 TC 3 Z9 3 U1 0 U2 7 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 2151-0032 EI 2151-0040 J9 T ASABE JI Trans. ASABE PD MAY-JUN PY 2014 VL 57 IS 3 BP 973 EP 986 PG 14 WC Agricultural Engineering SC Agriculture GA AM7XK UT WOS:000340081800026 ER PT J AU Hughes, JM Smith, MA Hydren, JR Henning, PC Scofield, DE Spiering, BA Staab, JS Nindl, BC Matheny, RW AF Hughes, Julie M. Smith, Martha A. Hydren, Jay R. Henning, Paul C. Scofield, Dennis E. Spiering, Barry A. Staab, Jeffery S. Nindl, Bradley C. Matheny, Ronald W., Jr. TI Bone Formation is Suppressed with US Army Ranger Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Hughes, Julie M.; Hydren, Jay R.; Henning, Paul C.; Scofield, Dennis E.; Spiering, Barry A.; Staab, Jeffery S.; Matheny, Ronald W., Jr.] US Army Res Inst Environm Med, Natick, MA USA. [Smith, Martha A.] Madigan Healthcare Syst, Tacoma, WA USA. [Nindl, Bradley C.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RI SCOFIELD, DENNIS/F-3636-2015; Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 186 BP 36 EP 36 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115900075 ER PT J AU Henning, PC Margolis, LM McClung, JP Young, AJ Pasiakos, SM AF Henning, Paul C. Margolis, Lee M. McClung, James P. Young, Andrew J. Pasiakos, Stefan M. TI High Protein Diets Do Not Attenuate Decrements In Testosterone And IGF-I During An Energy Deficit SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Henning, Paul C.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 386 BP 100 EP 100 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115900274 ER PT J AU Gist, NH AF Gist, Nicholas H. TI Physiological And Performance Effects Of Low-volume, High-intensity Whole-body Calisthenics On Army ROTC Cadets SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Gist, Nicholas H.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 432 BP 116 EP 116 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115900320 ER PT J AU Gagnon, D Schlader, ZJ Rivas, E Langlois, J Kennedy, N Cap, AP Convertino, VA Crandall, CG AF Gagnon, Daniel Schlader, Zachary J. Rivas, Eric Langlois, Jena Kennedy, Naomi Cap, Andrew P. Convertino, Victor A. Crandall, Craig G. TI Does Hyperthermia Alter Teg-based Markers Of Hemostasis During Simulated Hemorrhage In Humans? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Gagnon, Daniel; Schlader, Zachary J.; Rivas, Eric; Langlois, Jena; Kennedy, Naomi; Crandall, Craig G.] Inst Exercise & Environm Med, Dallas, TX USA. [Cap, Andrew P.; Convertino, Victor A.] US Army Inst Surg Res, Houston, TX USA. OI Rivas, Eric/0000-0002-4657-8292 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 698 BP 180 EP 180 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115901152 ER PT J AU Carlson, LA Ferguson, D Kenefick, RW AF Carlson, Lara A. Ferguson, David Kenefick, Robert W. TI Physiological Strain Of Motorsport Athletes During Competitive Racecar Driving SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Carlson, Lara A.] Univ New England, Biddeford, ME USA. [Ferguson, David] Baylor Coll Med, Houston, TX 77030 USA. [Kenefick, Robert W.] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 711 BP 184 EP 184 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115901165 ER PT J AU Szczepanik, M Meyering, C Bojescul, J AF Szczepanik, Michelle Meyering, Christopher Bojescul, John TI Concerning Knee Pain in an Unconcerned Adolescent Football Player SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Szczepanik, Michelle] Ft Belvoir Community Hosp, Ft Belvoir, VA USA. [Meyering, Christopher; Bojescul, John] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1259 BP 320 EP 320 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115902104 ER PT J AU DiPasquale, DM Strangman, GE Muza, SR AF DiPasquale, Dana M. Strangman, Gary E. Muza, Stephen R. TI Comparing the Effects of Exercise in Hypobaric and Normobaric Hypoxia on Acute Mountain Sickness SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [DiPasquale, Dana M.; Strangman, Gary E.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Charlestown, MA USA. [Muza, Stephen R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1564 BP 425 EP 425 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115903009 ER PT J AU Fellin, RE Goss, DL Sauer, SG Warr, BJ Seay, JF AF Fellin, Rebecca E. Goss, Donald L. Sauer, Shane G. Warr, Bradley J. Seay, Joseph F. TI Habitual Runners in Minimalist Footwear are Mostly Heelstrikers in a Cohort of US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Fellin, Rebecca E.; Sauer, Shane G.; Warr, Bradley J.; Seay, Joseph F.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Goss, Donald L.] US Army, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2233 BP 589 EP 589 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904051 ER PT J AU Schumacher, RM Mayhew, JL Mann, JB Brechue, WF AF Schumacher, Richard M. Mayhew, Jerry L. Mann, J. Bryan Brechue, William F. TI Changes in Body Composition Components over a Year in College Football Players SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Schumacher, Richard M.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Mann, J. Bryan] Univ Missouri, Columbia, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2303 BP 613 EP 613 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904108 ER PT J AU Crowder, TA AF Crowder, Todd A. TI Sex Differences on Army Mobility Field Test Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2592 BP 706 EP 706 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904397 ER PT J AU Sauer, SG Walker, LA Frykman, PN Fulco, CS Seay, JF AF Sauer, Shane G. Walker, Leila A. Frykman, Peter N. Fulco, Charles S. Seay, Joseph F. TI Comparison Of Graded Maximal Effort Tests In Soldiers: Prolonged Loaded Walk Vs. Run SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Sauer, Shane G.; Walker, Leila A.; Frykman, Peter N.; Fulco, Charles S.; Seay, Joseph F.] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2590 BP 706 EP 706 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904395 ER PT J AU Sell, TC Abt, J Lovalekar, M Bozich, T Benson, P Morgan, J Lephart, S AF Sell, Timothy C. Abt, John Lovalekar, Mita Bozich, Tony Benson, Peter Morgan, Jeffrey Lephart, Scott TI Injury Epidemiology of US Army Special Operations Forces SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Sell, Timothy C.; Abt, John; Lovalekar, Mita; Bozich, Tony; Lephart, Scott] Univ Pittsburgh, Pittsburgh, PA USA. [Benson, Peter; Morgan, Jeffrey] US Army Special Operat Command AOMD, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2814 BP 759 EP 759 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905146 ER PT J AU Knapik, J Steelman, R Hoedebecke, K Colliver, K Klug, K Rankin, S Grier, T Jones, BH AF Knapik, Joseph Steelman, Ryan Hoedebecke, Kyle Colliver, Keith Klug, Kevin Rankin, Shawn Grier, Tyson Jones, Bruce H. TI Comparison of Injury Incidence with Two United States Military Parachute Systems (T-10 and T-11) SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Knapik, Joseph; Steelman, Ryan; Grier, Tyson; Jones, Bruce H.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Hoedebecke, Kyle] Womack Army Med Ctr, Ft Bragg, NC USA. [Colliver, Keith] Jacobs Syst Engn Tech Assistance Team, Ft Belvoir, VA USA. [Klug, Kevin; Rankin, Shawn] Concurrent Technol Corp, Fayetteville, AR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2821 BP 761 EP 762 PG 2 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905153 ER PT J AU Warr, BJ Fellin, RE Frykman, PN Sauer, SG Goss, DL Seay, JF AF Warr, Bradley J. Fellin, Rebecca E. Frykman, Peter N. Sauer, Shane G. Goss, Donald L. Seay, Joseph F. TI Footstrike Patterns do not Influence Running Related Overuse Injuries in US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Warr, Bradley J.; Fellin, Rebecca E.; Frykman, Peter N.; Sauer, Shane G.; Seay, Joseph F.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Goss, Donald L.] US Army, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2977 BP 812 EP 812 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905306 ER PT J AU Seay, JF Warr, BJ Winkler, AE Sauer, SG Fellin, RE AF Seay, Joseph F. Warr, Bradley J. Winkler, Amanda E. Sauer, Shane G. Fellin, Rebecca E. TI Footstrike Pattern Characterization and Relationship to Performance in a Cohort Of US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Seay, Joseph F.; Warr, Bradley J.; Winkler, Amanda E.; Sauer, Shane G.; Fellin, Rebecca E.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2978 BP 813 EP 813 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905307 ER PT J AU Denkinger, TR Maakasted, KA Hill, JL Arabas, JL Brechue, WF Mayhew, JL AF Denkinger, Taylor R. Maakasted, Kirsten A. Hill, Jennifer L. Arabas, Jana L. Brechue, William F. Mayhew, Jerry L. TI Accuracy Of Push-up Performance For Tracking Changes In 1RM Bench Press In College Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Denkinger, Taylor R.; Maakasted, Kirsten A.; Hill, Jennifer L.; Arabas, Jana L.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Brechue, William F.] United State Mil Acad, West Point, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2998 BP 819 EP 819 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905326 ER PT J AU Cheuvront, SN AF Cheuvront, Samuel N. TI Match maker: how to compare thermoregulatory responses in groups of different body mass and surface area SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Editorial Material ID EXERCISE; HEAT C1 US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 7 TC 5 Z9 5 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2014 VL 116 IS 9 BP 1121 EP 1122 DI 10.1152/japplphysiol.00248.2014 PG 2 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AL5IO UT WOS:000339167300001 PM 24651989 ER PT J AU Jacobs, AC Thompson, MG Black, CC Kessler, JL Clark, LP McQueary, CN Gancz, HY Corey, BW Moon, JK Si, YZ Owen, MT Hallock, JD Kwak, YI Summers, A Li, CZ Rasko, DA Penwell, WF Honnold, CL Wise, MC Waterman, PE Lesho, EP Stewart, RL Actis, LA Palys, TJ Craft, DW Zurawski, DV AF Jacobs, Anna C. Thompson, Mitchell G. Black, Chad C. Kessler, Jennifer L. Clark, Lily P. McQueary, Christin N. Gancz, Hanan Y. Corey, Brendan W. Moon, Jay K. Si, Yuanzheng Owen, Matthew T. Hallock, Justin D. Kwak, Yoon I. Summers, Amy Li, Charles Z. Rasko, David A. Penwell, William F. Honnold, Cary L. Wise, Matthew C. Waterman, Paige E. Lesho, Emil P. Stewart, Rena L. Actis, Luis A. Palys, Thomas J. Craft, David W. Zurawski, Daniel V. TI AB5075, a Highly Virulent Isolate of Acinetobacter baumannii, as a Model Strain for the Evaluation of Pathogenesis and Antimicrobial Treatments SO MBIO LA English DT Article ID GALLERIA-MELLONELLA; SYSTEM; OSTEOMYELITIS; RESISTANCE; INFECTION; IDENTIFICATION; VALIDATION; MILITARY; COLISTIN; CLONING AB Acinetobacter baumannii is recognized as an emerging bacterial pathogen because of traits such as prolonged survival in a desiccated state, effective nosocomial transmission, and an inherent ability to acquire antibiotic resistance genes. A pressing need in the field of A. baumannii research is a suitable model strain that is representative of current clinical isolates, is highly virulent in established animal models, and can be genetically manipulated. To identify a suitable strain, a genetically diverse set of recent U. S. military clinical isolates was assessed. Pulsed-field gel electrophoresis and multiplex PCR determined the genetic diversity of 33 A. baumannii isolates. Subsequently, five representative isolates were tested in murine pulmonary and Galleria mellonella models of infection. Infections with one strain, AB5075, were considerably more severe in both animal models than those with other isolates, as there was a significant decrease in survival rates. AB5075 also caused osteomyelitis in a rat open fracture model, while another isolate did not. Additionally, a Tn5 transposon library was successfully generated in AB5075, and the insertion of exogenous genes into the AB5075 chromosome via Tn7 was completed, suggesting that this isolate may be genetically amenable for research purposes. Finally, proof-of-concept experiments with the antibiotic rifampin showed that this strain can be used in animal models to assess therapies under numerous parameters, including survival rates and lung bacterial burden. We propose that AB5075 can serve as a model strain for A. baumannii pathogenesis due to its relatively recent isolation, multidrug resistance, reproducible virulence in animal models, and genetic tractability. IMPORTANCE The incidence of A. baumannii infections has increased over the last decade, and unfortunately, so has antibiotic resistance in this bacterial species. A. baumannii is now responsible for more than 10% of all hospital-acquired infections in the United States and has a > 50% mortality rate in patients with sepsis and pneumonia. Most research on the pathogenicity of A. baumannii focused on isolates that are not truly representative of current multidrug-resistant strains isolated from patients. After screening of a panel of isolates in different in vitro and in vivo assays, the strain AB5075 was selected as more suitable for research because of its antibiotic resistance profile and increased virulence in animal models. Moreover, AB5075 is susceptible to tetracycline and hygromycin, which makes it amenable to genetic manipulation. Taken together, these traits make AB5075 a good candidate for use in studying virulence and pathogenicity of this species and testing novel antimicrobials. C1 [Jacobs, Anna C.; Thompson, Mitchell G.; Black, Chad C.; Kessler, Jennifer L.; Clark, Lily P.; McQueary, Christin N.; Gancz, Hanan Y.; Corey, Brendan W.; Moon, Jay K.; Si, Yuanzheng; Summers, Amy; Li, Charles Z.; Palys, Thomas J.; Craft, David W.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA. [Owen, Matthew T.; Hallock, Justin D.; Stewart, Rena L.] Univ Alabama Birmingham, Div Orthopaed, Birmingham, AL USA. [Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism & Surveillance Netwo, Silver Spring, MD USA. [Rasko, David A.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Penwell, William F.; Actis, Luis A.] Miami Univ, Dept Microbiol, Oxford, OH 45056 USA. [Honnold, Cary L.; Wise, Matthew C.] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA. EM daniel.v.zurawski.ctr@mail.mil RI Chiang, Vincent, Ming-Hsien/D-4312-2016; OI Chiang, Vincent, Ming-Hsien/0000-0002-2029-7863; David, Rasko/0000-0002-7337-7154; Zurawski, Daniel/0000-0002-7920-5601 FU Military Infectious Diseases Research Program (MIDRP); Defense Medical Research and Development Program (DMRDP) FX The Zurawski laboratory and the research performed in this study were supported and funded via multiple grants from the Military Infectious Diseases Research Program (MIDRP) and the Defense Medical Research and Development Program (DMRDP). NR 41 TC 28 Z9 29 U1 2 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAY-JUN PY 2014 VL 5 IS 3 AR e01076-14 DI 10.1128/mBio.01076-14 PG 10 WC Microbiology SC Microbiology GA AL1HH UT WOS:000338875900033 PM 24865555 ER PT J AU Ladner, JT Beitzel, B Chain, PSG Davenport, MG Donaldson, EF Frieman, M Kugelman, JR Kuhn, JH O'Rear, J Sabeti, PC Wentworth, DE Wiley, MR Yu, GY Sozhamannan, S Bradburne, C Palacios, G AF Ladner, Jason T. Beitzel, Brett Chain, Patrick S. G. Davenport, Matthew G. Donaldson, Eric F. Frieman, Matthew Kugelman, Jeffrey R. Kuhn, Jens H. O'Rear, Jules Sabeti, Pardis C. Wentworth, David E. Wiley, Michael R. Yu, Guo-Yun Sozhamannan, Shanmuga Bradburne, Christopher Palacios, Gustavo CA Threat Characterization Consortium TI Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing SO MBIO LA English DT Editorial Material ID DISCOVERY; VIRUSES; CORONAVIRUS; POPULATION; DIVERSITY; CHINA AB Thanks to high-throughput sequencing technologies, genome sequencing has become a common component in nearly all aspects of viral research; thus, we are experiencing an explosion in both the number of available genome sequences and the number of institutions producing such data. However, there are currently no common standards used to convey the quality, and therefore utility, of these various genome sequences. Here, we propose five "standard" categories that encompass all stages of viral genome finishing, and we define them using simple criteria that are agnostic to the technology used for sequencing. We also provide genome finishing recommendations for various downstream applications, keeping in mind the cost-benefit trade-offs associated with different levels of finishing. Our goal is to define a common vocabulary that will allow comparison of genome quality across different research groups, sequencing platforms, and assembly techniques. C1 [Ladner, Jason T.; Beitzel, Brett; Kugelman, Jeffrey R.; Wiley, Michael R.; Yu, Guo-Yun; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. [Chain, Patrick S. G.] Los Alamos Natl Lab, Bioinformat & Analyt Team, Biosci Div, Los Alamos, NM USA. [Davenport, Matthew G.; Bradburne, Christopher] Johns Hopkins Univ, Appl Phys Lab, Natl Secur Syst Biol Ctr, Asymmetr Operat Sect, Laurel, MD USA. [Donaldson, Eric F.; O'Rear, Jules] US FDA, Silver Spring, MD USA. [Frieman, Matthew] Univ Maryland, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Sabeti, Pardis C.] Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA. [Sabeti, Pardis C.] Broad Inst, Cambridge, MA USA. [Wentworth, David E.] J Craig Venter Inst, Rockville, MD USA. [Threat Characterization Consortium] Def Threat Reduct Agcy, Threat Characterizat Consortium, Ft Belvoir, VA USA. [Sozhamannan, Shanmuga] GoldBelt Raven LLC, Frederick, MD USA. [Sozhamannan, Shanmuga] Joint Program Execut Off, Crit Reagents Program, Ft Detrick, MD USA. RP Ladner, JT (reprint author), US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. EM jason.t.ladner.ctr@mail.mil; gustavo.f.palacios.ctr@mail.mil RI Kuhn, Jens H./B-7615-2011; Palacios, Gustavo/I-7773-2015; OI Kuhn, Jens H./0000-0002-7800-6045; Palacios, Gustavo/0000-0001-5062-1938; Wentworth, David/0000-0002-5190-980X; Chain, Patrick/0000-0003-3949-3634 FU NIAID NIH HHS [HHSN272200700016I]; PHS HHS [HHSN272200700016I] NR 23 TC 20 Z9 20 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAY-JUN PY 2014 VL 5 IS 3 AR e01360-14 DI 10.1128/mBio.01360-14 PG 5 WC Microbiology SC Microbiology GA AL1HH UT WOS:000338875900037 PM 24939889 ER PT J AU DeGrasse, S Rivera, V Roach, J White, K Callahan, J Couture, D Simone, K Peredy, T Poli, M AF DeGrasse, Stacey Rivera, Victor Roach, John White, Kevin Callahan, John Couture, Darcie Simone, Karen Peredy, Tamas Poli, Mark TI Paralytic shellfish toxins in clinical matrices: Extension of AOAC official method 2005.06 to human urine and serum and application to a 2007 case study in Maine SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY LA English DT Article DE LC; -FD Paralytic shellfish poisoning; Saxitoxin; Serum; Urine ID SINGLE-LABORATORY VALIDATION; POSTMORTEM ANALYSIS; NEOSAXITOXIN; SAXITOXIN; SAMPLES; PSP AB Paralytic shellfish poisoning (PSP), a potentially fatal foodborne illness, is often diagnosed anecdotally based on symptoms and dietary history. The neurotoxins responsible for PSP, collectively referred to as the saxitoxins or paralytic shellfish toxins (PSTs), are natural toxins, produced by certain dinoflagellates, that may accumulate in seafood, particularly filter-feeding bivalves. Illnesses are rare because of effective monitoring programs, yet occasional poisonings occur. Rarely are contaminated food and human clinical samples (e.g., urine and serum) available for testing. There are currently few methods, none of which are validated, for determining PSTs in clinical matrices. This study evaluated AOAC (Association of Analytical Communities) Official Method of Analysis (OMA) 2005.06. [AOAC Official Method 2005.06 Paralytic Shellfish Poisoning Toxins in Shellfish: Prechormatographic Oxidation and Liquid Chromatography with Fluorescence Detection. In Official Methods of Analysis of AOAC International < http://www.eoma.aoac.org >],validatedonlyfor shellfish extracts, for its extension to human urine and serum samples. Initial assessment of control urine and serum matrices resulted in a sample cleanup modification when working with urine to remove hippuric acid, a natural urinary compound of environmental/dietary origin, which co-eluted with saxitoxin. Commercially available urine and serum matrices were then quantitatively spiked with PSTs that were available as certified reference materials (STX, dcSTX, BI, GTX2/3, C1/2, NEO, and GTX1/4) to assess method performance characteristics. The method was subsequently applied successfully to a PSP case study that occurred in July 2007 in Maine. Not only were PSTs identified in the patient urine and serum samples, the measured time series also led to the first report of human PST-specific urinary elimination rates. The LC-FD data generated from this case study compared remarkably well to results obtained using AOAC OMA 2011.27 [AOAC Official Method 2011.27 Paralytic Shellfish Toxins (PSTs) in Shellfish, Receptor Binding Assay. In Official Methods of Analysis of AOAC International < http://www.eoma.aoac.org >], further demonstrating successful extension of the LC-FD method to these clinical matrices. Moreover, data generated from this poisoning event reiterated that urine is a preferable clinical matrix, compared to serum, for diagnostic purposes due to higher accumulation and longer residence times in urine. Published by Elsevier Ltd. C1 [DeGrasse, Stacey; Roach, John; White, Kevin; Callahan, John] US FDA, Ctr Food Safety & Appl Nutr, Div Analyt Chem, Spect & Mass Spectrometry Branch, College Pk, MD 20740 USA. [Rivera, Victor; Poli, Mark] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Couture, Darcie] Maine Dept Marine Resources, West Boothbay Harbor, ME 04575 USA. [Simone, Karen; Peredy, Tamas] Northern New England Poison Ctr, Portland, ME 04103 USA. RP DeGrasse, S (reprint author), US FDA, Ctr Food Safety & Appl Nutr, Div Analyt Chem, Spect & Mass Spectrometry Branch, 5100 Paint Branch Pkwy, College Pk, MD 20740 USA. EM Stacey.Degrasse@fda.hhs.gov OI DeGrasse, Stacey/0000-0001-7808-4193 FU JSTO-CBD/DTRA [05-4-81-051] FX This project was funded by JSTO-CBD/DTRA, Research Plan No. 05-4-81-051. We would like to acknowledge Luis Raez, Laurie Leder, Ellen Boudreau, Christa Madock, and Sarah Yachetti for technical assistance in the laboratory and Steve Conrad for data presentation assistance. We thank Lorrie Backer and Amy Robbins for information regarding illness reports and documented case studies in Maine. We extend gratitude to Douglas Osborne for assistance regarding human use approvals. We thank two anonymous reviewers for thorough comments that improved the quality of the manuscript. NR 26 TC 5 Z9 5 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0967-0645 EI 1879-0100 J9 DEEP-SEA RES PT II JI Deep-Sea Res. Part II-Top. Stud. Oceanogr. PD MAY PY 2014 VL 103 BP 368 EP 375 DI 10.1016/j.dsr2.2012.08.001 PG 8 WC Oceanography SC Oceanography GA AL0IM UT WOS:000338810600027 ER PT J AU Wright, L Bourne, A Furman, A Stone, M Rossetti, F Lumley, L AF Wright, L. Bourne, A. Furman, A. Stone, M. Rossetti, F. Lumley, L. TI Behavioral and neuropathological effects associated with subcutaneous exposure to sarin in juvenile rats SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Wright, L.; Bourne, A.; Furman, A.; Stone, M.; Lumley, L.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Rossetti, F.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA P11 BP 93 EP 93 DI 10.1016/j.ntt.2014.04.056 PG 1 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800063 ER PT J AU Citino, RM AF Citino, Robert M. TI Winning and Losing on the Western Front: The British Third Army and the Defeat of Germany SO GERMAN STUDIES REVIEW LA English DT Book Review C1 [Citino, Robert M.] US Army War Coll, Carlisle, PA 17013 USA. RP Citino, RM (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0149-7952 EI 2164-8646 J9 GER STUD REV JI Ger. Stud. Rev. PD MAY PY 2014 VL 37 IS 2 BP 449 EP 451 PG 3 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA AK9MF UT WOS:000338750500024 ER PT J AU Lee, J Kim, JG Mahon, SB Mukai, D Yoon, D Boss, GR Patterson, SE Rockwood, G Isom, G Brenner, M AF Lee, Jangwoen Kim, Jae G. Mahon, Sari B. Mukai, David Yoon, David Boss, Gerry R. Patterson, Steven E. Rockwood, Gary Isom, Gary Brenner, Matthew TI Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE diffuse optical spectroscopy; cytochrome c oxidase; physiological perturbation; cyanide poisoning; hemorrhage ID NEAR-INFRARED SPECTROSCOPY; PHOTON MIGRATION SPECTROSCOPY; SUBLETHAL CYANIDE TOXICITY; FREQUENCY-DOMAIN; RABBIT MODEL; BRAIN; OXYGENATION; HEMOGLOBIN; ABSORPTION; TISSUE AB A major need exists for methods to assess organ oxidative metabolic states in vivo. By contrasting the responses to cyanide (CN) poisoning versus hemorrhage in animal models, we demonstrate that diffuse optical spectroscopy (DOS) can detect cytochrome c oxidase (CcO) redox states. Intermittent decreases in inspired O-2 from 100% to 21% were applied before, during, and after CN poisoning, hemorrhage, and resuscitation in rabbits. Continuous DOS measurements of total hemoglobin, oxyhemoglobin, deoxyhemoglobin, and oxidized and reduced CcO from muscle were obtained. Rabbit hemorrhage was accomplished with stepwise removal of blood, followed by blood resuscitation. CN treated rabbits received 0.166 mg/min NaCN infusion. During hemorrhage, CcO redox state became reduced concurrently with decreases in oxyhemoglobin, resulting from reduced tissue oxygen delivery and hypoxia. In contrast, during CN infusion, CcO redox state decreased while oxyhemoglobin concentration increased due to CN binding and reduction of CcO with resultant inhibition of the electron transport chain. Spectral absorption similarities between hemoglobin and CcO make noninvasive spectroscopic distinction of CcO redox states difficult. By contrasting physiological perturbations of CN poisoning versus hemorrhage, we demonstrate that DOS measured CcO redox state changes are decoupled from hemoglobin concentration measurement changes. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 [Lee, Jangwoen; Kim, Jae G.; Mahon, Sari B.; Mukai, David; Yoon, David; Brenner, Matthew] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA. [Kim, Jae G.] Gwangju Inst Sci & Technol, Sch Informat & Commun, Dept Med Syst Engn, Kwangju 500712, South Korea. [Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Patterson, Steven E.] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA. [Rockwood, Gary] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Isom, Gary] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA. [Rockwood, Gary] Univ Calif Irvine, Med Ctr, Dept Pulm & Crit Care, Orange, CA 92868 USA. RP Lee, J (reprint author), Univ Calif Irvine, Beckman Laser Inst & Med Clin, 1002 Hlth Sci Rd East, Irvine, CA 92612 USA. EM jangwl@uci.edu; mbrenner@uci.edu FU CounterACT Program, Office of the Director, National Institutes of Health (OD); National Institute of Environmental Health Sciences (NIEHS) [1U54NS063718, 1U54NS079201, U01-NS058030, U54-NS079201]; AMRMC [W81XWH-12-2-0114]; Air Force [FA9550-04-1-0101, FA9550-08-1-0384, FA9550-10-1-0438]; H/NBIB Laser Microbeam and Medical Program [P41-EB015890] FX The authors acknowledge support by the CounterACT Program, Office of the Director, National Institutes of Health (OD) and the National Institute of Environmental Health Sciences (NIEHS), 1U54NS063718, 1U54NS079201, U01-NS058030, U54-NS079201, AMRMC W81XWH-12-2-0114, Air Force FA9550-04-1-0101, FA9550-08-1-0384, and FA9550-10-1-0438; the NIH/NBIB Laser Microbeam and Medical Program P41-EB015890. NR 47 TC 2 Z9 2 U1 0 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD MAY PY 2014 VL 19 IS 5 AR 055001 DI 10.1117/1.JBO.19.5.055001 PG 9 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AK3OR UT WOS:000338334600013 PM 24788369 ER PT J AU Steele, SR Bilchik, A Johnson, EK Nissan, A Peoples, GE Eberhardt, JS Kalina, P Petersen, B Brucher, B Protic, M Avital, I Stojadinovic, A AF Steele, Scott R. Bilchik, Anton Johnson, Eric K. Nissan, Aviram Peoples, George E. Eberhardt, John S. Kalina, Philip Petersen, Benjamin Bruecher, Bjoern Protic, Mladjan Avital, Itzhak Stojadinovic, Alexander TI Time-dependent Estimates of Recurrence and Survival in Colon Cancer: Clinical Decision Support System Tool Development for Adjuvant Therapy and Oncological Outcome Assessment SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT 119th Annual Scientific Session of the Western-Surgical-Association CY NOV 13-16, 2011 CL Tucson, AZ SP Western Surg Assoc ID BELIEF NETWORK MODEL; COLORECTAL-CANCER; CHEMOTHERAPY USE; INDIVIDUALIZED PREDICTION; NATIONAL GUIDELINES; ELDERLY-PATIENTS; EQUAL ACCESS; STAGE-II; AGE; POPULATION AB Unanswered questions remain in determining which high-risk node-negative colon cancer (CC) cohorts benefit from adjuvant therapy and how it may differ in an equal access population. Machine-learned Bayesian Belief Networks (ml-BBNs) accurately estimate outcomes in CC, providing clinicians with Clinical Decision Support System (CDSS) tools to facilitate treatment planning. We evaluated ml-BBNs ability to estimate survival and recurrence in CC. We performed a retrospective analysis of registry data of patients with CC to train-test-crossvalidate ml-BBNs using the Department of Defense Automated Central Tumor Registry (January 1993 to December 2004). Cases with events or follow-up that passed quality control were stratified into 1-, 2-, 3-, and 5-year survival cohorts. ml-BBNs were trained using machine-learning algorithms and k-fold crossvalidation and receiver operating characteristic curve analysis used for validation. BBNs were comprised of 5301 patients and areas under the curve ranged from 0.85 to 0.90. Positive predictive values for recurrence and mortality ranged from 78 to 84 per cent and negative predictive values from 74 to 90 per cent by survival cohort. In the 12-month model alone, 1,132,462,080 unique rule sets allow physicians to predict individual recurrence/mortality estimates. Patients with Stage II (N0M0) CC benefit from chemotherapy at different rates. At one year, all patients older than 73 years of age with T2-4 tumors and abnormal carcinoembryonic antigen levels benefited, whereas at five years, all had relative reduction in mortality with the largest benefit amongst elderly, highest T-stage patients. ml-BBN can readily predict which high-risk patients benefit from adjuvant therapy. CDSS tools yield individualized, clinically relevant estimates of outcomes to assist clinicians in treatment planning. C1 [Steele, Scott R.; Johnson, Eric K.; Peoples, George E.; Avital, Itzhak; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Steele, Scott R.; Bilchik, Anton; Johnson, Eric K.; Nissan, Aviram; Peoples, George E.; Bruecher, Bjoern; Protic, Mladjan; Avital, Itzhak; Stojadinovic, Alexander] US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. Div Biostat, Duarte, CA USA. [Eberhardt, John S.; Kalina, Philip; Petersen, Benjamin] DecisionQ Corp, Washington, DC USA. [Nissan, Aviram] Hadassah Hebrew Univ, Ctr Med, Dept Surg, Jerusalem, Israel. [Bilchik, Anton] John Wayne Canc Inst, Santa Monica, CA USA. [Bilchik, Anton] Calif Oncol Res Inst, Los Angeles, CA USA. [Steele, Scott R.; Johnson, Eric K.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Bruecher, Bjoern; Avital, Itzhak] Bon Secours Canc Inst, Richmond, VA USA. [Nissan, Aviram; Bruecher, Bjoern; Protic, Mladjan; Avital, Itzhak; Stojadinovic, Alexander] Int Consortium Res Excellence Theodor Billroth Ac, INCORE, Munich, Germany. [Protic, Mladjan] Clin Abdominal Endocrine & Transplantat Surg, Clin Ctr Vojvodina, Novi Sad, Serbia. [Protic, Mladjan] Univ Novi Sad, Fac Med, Novi Sad 21000, Serbia. RP Steele, SR (reprint author), 9606 Piperhill Dr SE, Olympia, WA 98513 USA. EM harkersteele@mac.com OI Brucher, Bjorn/0000-0002-3930-6416 NR 33 TC 1 Z9 1 U1 0 U2 4 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD MAY PY 2014 VL 80 IS 5 BP 441 EP 453 PG 13 WC Surgery SC Surgery GA AJ5RR UT WOS:000337745200014 PM 24887722 ER PT J AU Cheng, XG Yoo, JJ Hale, RG AF Cheng, XingGuo Yoo, James J. Hale, Robert G. TI Biomask for skin regeneration SO REGENERATIVE MEDICINE LA English DT Editorial Material DE biomask; burn; face; regeneration; restoration; scar; skin ID FACIAL BURNS; STEM-CELLS; FULL-FACE; WOUNDS C1 [Cheng, XingGuo] Southwest Res Inst, Microencapsulat & Nanomat Dept, San Antonio, TX 78238 USA. [Yoo, James J.] Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA. [Hale, Robert G.] US Army Dent & Trauma Res Detachment, US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cheng, XG (reprint author), Southwest Res Inst, Microencapsulat & Nanomat Dept, 6220 Culebra Rd, San Antonio, TX 78238 USA. EM xingguo.cheng@swri.org NR 19 TC 1 Z9 1 U1 0 U2 2 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0751 EI 1746-076X J9 REGEN MED JI Regen. Med. PD MAY PY 2014 VL 9 IS 3 BP 245 EP 248 DI 10.2217/RME.14.22 PG 4 WC Cell & Tissue Engineering; Engineering, Biomedical SC Cell Biology; Engineering GA AJ7ZU UT WOS:000337922200001 PM 24935034 ER PT J AU Scaravilli, V Kreyer, S Linden, K Belenkiy, S Jordan, B Pesenti, A Zanella, A Chung, K Cannon, J Cancio, LC Batchinsky, AI AF Scaravilli, Vittorio Kreyer, Stefan Linden, Katharina Belenkiy, Slava Jordan, Bryan Pesenti, Antonio Zanella, Alberto Chung, Kevin Cannon, Jeremy Cancio, Leopoldo C. Batchinsky, Andriy I. TI Modular Extracorporeal Life Support: Effects of Ultrafiltrate Recirculation on the Performance of an Extracorporeal Carbon Dioxide Removal Device SO ASAIO JOURNAL LA English DT Article DE extracorporeal carbon dioxide removal; hemofiltration; recirculation; respiratory dialysis ID ACUTE LUNG INJURY; POSITIVE-PRESSURE VENTILATION; RESPIRATORY-DISTRESS-SYNDROME; CO2 REMOVAL; MECHANICAL VENTILATION; MEMBRANE-OXYGENATION; 6 ML/KG; COAGULATION; EXPERIENCE; MORTALITY AB The combination of extracorporeal carbon dioxide removal (ECCO2R) and hemofiltration is a possible therapeutic strategy for patients needing both lung and renal support. We tested the effects of the recirculation of ultrafiltrate on membrane lung (ML) CO2 removal (VCO2ML). Three conscious, spontaneously breathing sheep were connected to a commercially produced ECCO2R device (Hemolung; Alung Technologies, Pittsburgh, PA) with a blood flow of 250 ml/min and a gas flow of 10 L/min. A hemofilter (NxStage, NxStage Medical, Lawrence, MA) was interposed in series after the ML. Ultrafiltrate flow was generated and recirculated before the ML. We tested four ultrafiltrate flows (0, 50, 100, and 150 ml/min) for 25 min each, eight times per animal, resulting in 24 randomized test repetitions. We recorded VCO2ML, hemodynamics and ventilatory variables, and natural lung CO2 transfer (VCO2NL) and collected arterial and circuitry blood samples. VCO2ML was unchanged by application of ultrafiltrate recirculation (40.5 +/- 4.0, 39.7 +/- 4.2, 39.8 +/- 4.2, and 39.2 +/- 4.1 ml/min, respectively, at ultrafiltrate flow of 0, 50, 100, and 150 ml/min). Minute ventilation, respiratory rate, VCO2NL, and arterial blood analyses were not affected by ultrafiltrate recirculation. In the tested configuration, ultrafiltrate recirculation did not affect VCO2ML. This modular technology may provide a suitable platform for coupling CO2 removal with various forms of blood purification. C1 [Scaravilli, Vittorio; Kreyer, Stefan; Linden, Katharina; Belenkiy, Slava; Jordan, Bryan; Chung, Kevin; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army, Inst Surg Res, Comprehens Intens Care Res Task Area, Battlefield Hlth & Trauma Res Inst, Ft Sam Houston, TX 78234 USA. [Scaravilli, Vittorio; Pesenti, Antonio; Zanella, Alberto] Univ Milano Bicocca, Dept Expt Med, Monza, MB, Italy. [Kreyer, Stefan] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany. [Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany. [Pesenti, Antonio] San Gerardo Hosp, Dept Perioperat Med & Intens Care, Monza, MB, Italy. [Cannon, Jeremy] San Antonio Mil Med Ctr, Dept Trauma & Crit Care, San Antonio, TX USA. RP Scaravilli, V (reprint author), US Army, Inst Surg Res, Comprehens Intens Care Res Task Area, Battlefield Hlth & Trauma Res Inst,JBSA, 3698 Chambers Pass,BHT 2, Ft Sam Houston, TX 78234 USA. EM vittorio.scara-villi@gmail.com OI zanella, Alberto/0000-0002-2967-2527 NR 32 TC 6 Z9 6 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1058-2916 EI 1538-943X J9 ASAIO J JI Asaio J. PD MAY-JUN PY 2014 VL 60 IS 3 BP 335 EP 341 DI 10.1097/MAT.0000000000000070 PG 7 WC Engineering, Biomedical; Transplantation SC Engineering; Transplantation GA AJ5LO UT WOS:000337724300014 PM 24614356 ER PT J AU Paris, R Kuschner, RA Binn, L Thomas, SJ Colloca, S Nicosia, A Cortese, R Bailer, RT Sullivan, N Koup, RA AF Paris, Robert Kuschner, Robert A. Binn, Leonard Thomas, Stephen J. Colloca, Stefano Nicosia, Alfredo Cortese, Riccardo Bailer, Robert T. Sullivan, Nancy Koup, Richard A. TI Adenovirus Type 4 and 7 Vaccination or Adenovirus Type 4 Respiratory Infection Elicits Minimal Cross-Reactive Antibody Responses to Nonhuman Adenovirus Vaccine Vectors SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID NEUTRALIZING ANTIBODIES; HIV-1 VACCINE; PREEXISTING IMMUNITY; MILITARY TRAINEES; DOUBLE-BLIND; IMMUNOGENICITY; IMMUNIZATION; EFFICACY; SAFETY; CANDIDATE AB Antivector immunity may limit the immunogenicity of adenovirus vector vaccines. We tested sera from individuals immunized with adenovirus type 4 and 7 (Ad4 and Ad7, respectively) vaccine or naturally infected with Ad4 for their ability to neutralize a panel of E1-deleted human and chimpanzee adenoviruses (ChAd). Small statistically significant increases in titers to ChAd63, ChAd3, human Ad35, and human Ad5 were observed. Neutralizing antibodies elicited by Ad4 infection or immunization results in a small amount of adenovirus cross-reactivity. C1 [Paris, Robert] Walter Reed Army Inst Res, US Mil Malaria Res Program, Silver Spring, MD USA. [Kuschner, Robert A.; Binn, Leonard; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Colloca, Stefano; Nicosia, Alfredo; Cortese, Riccardo] Okairos, Rome, Italy. [Nicosia, Alfredo; Cortese, Riccardo] CEINGE, Naples, Italy. [Nicosia, Alfredo] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy. [Bailer, Robert T.; Sullivan, Nancy; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Koup, RA (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM rkoup@mail.nih.gov FU Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health FX This research was supported by the Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health. NR 26 TC 6 Z9 6 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2014 VL 21 IS 5 BP 783 EP 786 DI 10.1128/CVI.00011-14 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AJ0NU UT WOS:000337352300024 PM 24623627 ER PT J AU Spalding, MD McIvor, AL Beck, MW Koch, EW Moller, I Reed, DJ Rubinoff, P Spencer, T Tolhurst, TJ Wamsley, TV van Wesenbeeck, BK Wolanski, E Woodroffe, CD AF Spalding, Mark D. McIvor, Anna L. Beck, Michael W. Koch, Evamaria W. Moeller, Iris Reed, Denise J. Rubinoff, Pamela Spencer, Thomas Tolhurst, Trevor J. Wamsley, Ty V. van Wesenbeeck, Bregje K. Wolanski, Eric Woodroffe, Colin D. TI Coastal Ecosystems: A Critical Element of Risk Reduction SO CONSERVATION LETTERS LA English DT Article DE Coastal hazards; hybrid engineering; mangrove; reef; risk reduction; salt marsh; seagrass; sea-level rise; storm surge; wave attenuation ID CORAL-REEF; MANAGED REALIGNMENT; CLIMATE-CHANGE; PHASE-SHIFTS; SALT MARSHES; SERVICES; VEGETATION; ELEVATION; DISSIPATION; DEGRADATION AB The conservation of coastal ecosystems can provide considerable coastal protection benefits, but this role has not been sufficiently accounted for in coastal planning and engineering. Substantial evidence now exists showing how, and under what conditions, ecosystems can play a valuable function in wave and storm surge attenuation, erosion reduction, and in the longer term maintenance of the coastal profile. Both through their capacity for self repair and recovery, and through the often considerable cobenefits they provide, ecosystems can offer notable advantages over traditional engineering approaches in some settings. They can also be combined in hybrid engineering designs. We make 10 recommendations to encourage the utilization of existing knowledge and to improve the incorporation of ecosystems into policy, planning and funding for coastal hazard risk reduction. C1 [Spalding, Mark D.] Nature Conservancy, Global Marine Team, Cambridge CB2 1TN, England. [Spalding, Mark D.] Univ Cambridge, Dept Zool, Conservat Sci Grp, Cambridge CB2 1TN, England. [McIvor, Anna L.] Univ Cambridge, Dept Geog, Cambridge Coastal Res Unit, Cambridge CB2 1TN, England. [McIvor, Anna L.; Beck, Michael W.] Univ Cambridge, Nat Conservancy, Global Marine Team, Cambridge CB2 1TN, England. [Koch, Evamaria W.] Univ Maryland, Ctr Environm Sci, Horn Point Lab, Cambridge, MD 21613 USA. [Moeller, Iris] Univ Cambridge, Dept Geog, Cambridge Coastal Res Unit, Cambridge CB2 1TN, England. [Reed, Denise J.] Water Inst Gulf, Baton Rouge, LA 70825 USA. [Rubinoff, Pamela] Univ Rhode Isl, Coastal Resources Ctr, Narragansett, RI 02882 USA. [Spencer, Thomas] Univ Cambridge, Dept Geog, Cambridge Coastal Res Unit, Cambridge CB2 1TN, England. [Tolhurst, Trevor J.] Univ E Anglia, Sch Environm Sci, Norwich NR4 7TJ, Norfolk, England. [Wamsley, Ty V.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [van Wesenbeeck, Bregje K.] Unit Coastal & Marine Syst, Deltares, Netherlands. [Wolanski, Eric] James Cook Univ, Townsville, Qld 4811, Australia. [Woodroffe, Colin D.] Univ Wollongong, Sch Earth & Environm Sci, Wollongong, NSW 2522, Australia. RP Spalding, MD (reprint author), Nature Conservancy, Global Marine Team, Downing St, Cambridge CB2 3EJ, England. EM mspalding@tnc.org RI Tolhurst, Trevor/B-1929-2008; TropWATER, Research ID/P-1401-2014; Woodroffe, Colin/K-5222-2015; OI Tolhurst, Trevor/0000-0002-8578-7580; Woodroffe, Colin/0000-0003-4476-6158; Moller, Iris/0000-0003-1971-2932 FU Forrest and Frances Lattner Foundation; Morgridge Ecosystem Services Fund; Wetlands International through project Mangrove Capital FX We acknowledge funding from this work provided to The Nature Conservancy by the Forrest and Frances Lattner Foundation and the The Morgridge Ecosystem Services Fund, and support from Wetlands International through their project Mangrove Capital. We are also grateful to the many participants who attended workshops held in Washington DC, Bogor, Indonesia, and Cambridge, UK which helped in the development of our ideas, including: Joanna Ellison, Filippo Ferrario, Catherine Lovelock, Karen McKee, David McKinnie, Imen Meliane, I. Nyoman Suryadiputra, Norio Tanaka, Femke Tonneijck, Mai Sy Tuan, Jan van Dalfsen, Pieter van Eijk, Jo Wilson, and Han Winterwerp. NR 48 TC 19 Z9 20 U1 7 U2 105 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1755-263X J9 CONSERV LETT JI Conserv. Lett. PD MAY-JUN PY 2014 VL 7 IS 3 BP 293 EP 301 DI 10.1111/conl.12074 PG 9 WC Biodiversity Conservation SC Biodiversity & Conservation GA AJ3TJ UT WOS:000337590000018 ER PT J AU Nutter, E Meyer, S Shaw-Battista, J Marowitz, A AF Nutter, Elizabeth Meyer, Shaunette Shaw-Battista, Jenna Marowitz, Amy TI Waterbirth: An Integrative Analysis of Peer-Reviewed Literature SO JOURNAL OF MIDWIFERY & WOMENS HEALTH LA English DT Review DE hydrotherapy; water immersion; labor; birth; waterbirth; natural childbirth; integrative review ID NEONATAL OUTCOMES; UNDERWATER BIRTH; DELIVERY; EXPERIENCE; WOMEN; RISK; PAIN AB Introduction Despite a growing body of evidence for waterbirth safety, a myriad of political and cultural issues result in limited use in US hospitals compared to other developed nations. The purpose of this article is to critically analyze the evidence on maternal and neonatal outcomes of waterbirth to help inform evidence-based clinical practice in the United States. Methods A literature search was performed using electronic databases CINAHL, Ovid MEDLINE, PubMed, EMBASE, and PsycINFO. Thirty-eight studies, including 2 randomized controlled trials and 36 observational studies, were reviewed. Studies were conducted in 11 countries, mostly outside the United States. More than 31,000 waterbirths were described. Results Aggregate results suggest that waterbirth is associated with high levels of maternal satisfaction with pain relief and the experience of childbirth, and may increase the likelihood of an intact perineum. Waterbirth is associated with decreased incidence of episiotomy and severe perineal lacerations, and may contribute to reduced postpartum hemorrhage. Data indicate no difference in maternal or neonatal infection rates or nursery admissions after waterbirth. Neonatal mortality rates are low and similar after waterbirth and uncomplicated conventional birth. The calculated cord avulsion rate is 2.4 per 1000 waterbirths; it is unknown how this compares to conventional birth due to a lack of data that permits direct comparison. Discussion The majority of waterbirth research to date is observational and descriptive; thus, reported outcomes do not demonstrate causal associations. However, existing evidence is reassuring. Case-controlled studies have included thousands of women who gave birth underwater without an apparent increase in maternal or neonatal morbidity or mortality. Potential risks associated with waterbirth for women and neonates appear minimal, and outcomes are comparable to those expected in any healthy childbearing population. (C) 2014 by the American College of Nurse-Midwives. C1 [Nutter, Elizabeth] US Army, Ft Wainwright, AK 99703 USA. [Meyer, Shaunette] Univ Colorado, Denver, CO 80202 USA. [Shaw-Battista, Jenna] Univ Calif San Francisco, Dept Family Hlth Care Nursing, Nurse Midwifery Educ Program, San Francisco, CA 94143 USA. [Marowitz, Amy] Frontier Nursing Univ, Hyden, KY 41749 USA. RP Nutter, E (reprint author), US Army, Ft Wainwright, AK 99703 USA. EM Nuttercnm@gmail.com NR 52 TC 9 Z9 9 U1 5 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-9523 EI 1542-2011 J9 J MIDWIFERY WOM HEAL JI J. Midwifery Women Health PD MAY-JUN PY 2014 VL 59 IS 3 BP 286 EP 319 DI 10.1111/jmwh.12194 PG 34 WC Nursing SC Nursing GA AJ3QG UT WOS:000337581300008 PM 24850284 ER PT J AU Nutter, E Shaw-Battista, J Marowitz, A AF Nutter, Elizabeth Shaw-Battista, Jenna Marowitz, Amy TI Waterbirth Fundamentals for Clinicians SO JOURNAL OF MIDWIFERY & WOMENS HEALTH LA English DT Editorial Material ID BIRTH C1 [Nutter, Elizabeth] US Army, Ft Wainwright, AK USA. [Shaw-Battista, Jenna] Univ Calif San Francisco, Dept Family Hlth Care Nursing, Nurse Midwifery Educ Program, San Francisco, CA 94143 USA. [Marowitz, Amy] Frontier Nursing Univ, Hyden, KY 41749 USA. RP Nutter, E (reprint author), 1331 B Normandy CT, Ft Wainwright, AK 99703 USA. EM Nursenutter@gmail.com NR 22 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-9523 EI 1542-2011 J9 J MIDWIFERY WOM HEAL JI J. Midwifery Women Health PD MAY-JUN PY 2014 VL 59 IS 3 BP 350 EP 354 DI 10.1111/jmwh.12193 PG 5 WC Nursing SC Nursing GA AJ3QG UT WOS:000337581300013 PM 24758472 ER PT J AU Ben Salah, A Zaatour, A Ben Messaoud, N Kidar, A Smith, PL Kopydlowski, KM Kreishman-Deitrick, M Nielsen, CJ Novitt-Moreno, A Ransom, JH Morizot, G Grogl, M Buffet, PA AF Ben Salah, Afif Zaatour, Amor Ben Messaoud, Nathalie Kidar, Abdelhamid Smith, Philip L. Kopydlowski, Karen M. Kreishman-Deitrick, Mara Nielsen, Carl J. Novitt-Moreno, Anne Ransom, Janet H. Morizot, Gloria Grogl, Max Buffet, Pierre A. TI Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Editorial Material ID CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; PAROMOMYCIN; GENTAMICIN; AMINOSIDINE; MICE C1 [Ben Salah, Afif; Zaatour, Amor; Ben Messaoud, Nathalie] Inst Pasteur Tunis, Tunis, Tunisia. [Kidar, Abdelhamid] Reg Hosp Gafsa, Gafsa, Tunisia. [Smith, Philip L.; Kopydlowski, Karen M.; Kreishman-Deitrick, Mara; Nielsen, Carl J.] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Novitt-Moreno, Anne; Ransom, Janet H.] Fast Track Drugs & Biol LLC, North Potomac, MD USA. [Morizot, Gloria; Buffet, Pierre A.] AP HP, Paris, France. [Grogl, Max] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Ben Salah, A (reprint author), Inst Pasteur Tunis, Tunis, Tunisia. EM max.grogl@gmail.com NR 12 TC 0 Z9 0 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2014 VL 8 IS 5 AR e2749 DI 10.1371/journal.pntd.0002749 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AJ5OS UT WOS:000337735100008 PM 24853096 ER PT J AU Pethel, SD Hahs, DW AF Pethel, Shawn D. Hahs, Daniel W. TI Exact Test of Independence Using Mutual Information SO ENTROPY LA English DT Article DE mutual information; significance test; surrogate data AB Using a recently discovered method for producing random symbol sequences with prescribed transition counts, we present an exact null hypothesis significance test (NHST) for mutual information between two random variables, the null hypothesis being that the mutual information is zero (i.e., independence). The exact tests reported in the literature assume that data samples for each variable are sequentially independent and identically distributed (iid). In general, time series data have dependencies (Markov structure) that violate this condition. The algorithm given in this paper is the first exact significance test of mutual information that takes into account the Markov structure. When the Markov order is not known or indefinite, an exact test is used to determine an effective Markov order. C1 [Pethel, Shawn D.] US Army RDECOM, RDMR WDS WO, Redstone Arsenal, AL 35898 USA. [Hahs, Daniel W.] Torch Technol Inc, Huntsville, AL 35802 USA. RP Pethel, SD (reprint author), US Army RDECOM, RDMR WDS WO, Redstone Arsenal, AL 35898 USA. EM shawn.pethel@us.army.mil; daniel.w.hahs.ctr@mail.mil NR 12 TC 4 Z9 4 U1 0 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1099-4300 J9 ENTROPY-SWITZ JI Entropy PD MAY PY 2014 VL 16 IS 5 BP 2839 EP 2849 DI 10.3390/e16052839 PG 11 WC Physics, Multidisciplinary SC Physics GA AI9KV UT WOS:000337252400024 ER PT J AU Cheng, K Escalon, BL Robert, J Chinchar, VG Garcia-Reyero, N AF Cheng, Kwang Escalon, B. Lynn Robert, Jacques Chinchar, V. Gregory Garcia-Reyero, Natalia TI Differential transcription of fathead minnow immune-related genes following infection with frog virus 3, an emerging pathogen of ectothermic vertebrates SO VIROLOGY LA English DT Article DE Ranavirus; Iridovirus; Anti-viral immunity; Interferon; FHM microarray; Fathead minnow cells; Immune-related genes; Frog virus 3; 18K knock out mutant ID SINGAPORE GROUPER IRIDOVIRUS; LYSOSOMAL THIOL REDUCTASE; WEST NILE VIRUS; PROTEIN-SYNTHESIS; EPINEPHELUS-COIOIDES; FAMILY IRIDOVIRIDAE; ANTIVIRAL ACTIVITY; SIGNALING PATHWAY; ADAPTIVE IMMUNITY; UBIQUITIN LIGASE AB Frog virus 3 (FV3) and other ranaviruses are responsible for die-offs involving wild, farmed, and captive amphibians, fish, and reptiles. To ascertain which elements of the immune system respond to infection, we explored transcriptional responses following infection of fathead minnow cells with either wild type (wt) FV3 or a knock out (KO) mutant targeting the 18 kDa immediate early gene (18K). At 8 h post infection we observed marked upregulation of multiple transcripts encoding proteins affecting innate and acquired immunity. Sequences expressed 4-fold or higher in wt-infected cells included transcripts encoding interferon (IFN), IFN regulatory factors (IRFs), IFN stimulated genes (ISGs) such as Mx and MHC class I, and interleukins IL-1 beta, IL-8, IL-17C and IL-12. Cells infected with the 18K KO mutant (Delta 18K) showed qualitative differences and lower levels of induction. Collectively, these results indicate that ranavirus infection induced expression of multiple cellular genes affecting both innate and acquired immunity. (C) 2014 Elsevier Inc. All rights reserved. C1 [Cheng, Kwang; Chinchar, V. Gregory] Univ Mississippi, Med Ctr, Dept Microbiol, Jackson, MS 39211 USA. [Escalon, B. Lynn] Engn Res & Dev Ctr, US Army Corps Engn, Vicksburg, MS 39180 USA. [Robert, Jacques] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14642 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. RP Chinchar, VG (reprint author), Univ Mississippi, Med Ctr, Dept Microbiol, Jackson, MS 39211 USA. EM vchinchar@umc.edu FU US Army Environmental Quality Research Program [BAA 11-4838]; National Science Foundation [IOS 07-42711]; University of Mississippi Medical Center; National Institutes of Health [R24-AI-059830]; Chief of Engineers, US Army Corps of Engineers FX This work was partially funded by the US Army Environmental Quality Research Program (including BAA 11-4838), the National Science Foundation (IOS 07-42711), the University of Mississippi Medical Center, and the National Institutes of Health (R24-AI-059830). Permission for publishing has been granted by the Chief of Engineers, US Army Corps of Engineers. NR 66 TC 4 Z9 4 U1 2 U2 18 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAY PY 2014 VL 456 BP 77 EP 86 DI 10.1016/j.virol.2014.03.014 PG 10 WC Virology SC Virology GA AI9NF UT WOS:000337258600008 PM 24889227 ER PT J AU Cartagena, CM Phillips, KL Tortella, FC Dave, JR Schmid, KE AF Cartagena, Casandra M. Phillips, Katie L. Tortella, Frank C. Dave, Jitendra R. Schmid, Kara E. TI Temporal alterations in aquaporin and transcription factor HIF1 alpha et expression following penetrating ballistic-like brain injury (PBBI) SO MOLECULAR AND CELLULAR NEUROSCIENCE LA English DT Article DE Penetrating brain injury; PBBI; Edema; Aquaporins ID EDEMA FORMATION; WATER CHANNELS; RAT-BRAIN; BLOOD; MODEL; MECHANISMS; HEMORRHAGE; CELLS; HIF-1; FLUID AB Objectives: Brain edema is a primary factor in the morbidity and mortality of traumatic brain injury (TBI). The various isoforms of aquaporin 4 (AQP4) and aquaporin 9 (AQP9) are important factors influencing edema following TBI. Others have reported that these AQPs are regulated by the transcription factor hypoxia inducible factor (HIF)1 alpha. Therefore, we examined the temporal alterations in the multiple isoforms of AQP4 and AQP9, and its possible upstream regulation by HIF1 alpha, and evaluated whether different severities of penetrating injury influence these mechanisms. Methods: In the penetrating ballistic-like brain injury (PBBI) model, a temporary cavity and resultant injury was formed by the rapid inflation/deflation (i.e. <40 ms) of an elastic balloon attached to the end of the custom probe, injuring 10% of total rat brain volume. Tissue from the ipsilateral core and perilesional injury zones was collected. Total RNA was isolated at 4, 12, and 24 h, 3 and 7 days post-injury (sham and PBBI, n = 6 per group). cDNA was synthesized using oligodT primers. Quantitative real time PCR was performed using Taqman expression assays for aqp4 (recognizing all isoforms), aqp9, and hif1 alpha. Using separate animals, tissue lysate was collected at 4 and 24 h, 3 and 7 days post-injury and analyzed by immunoblot for protein expression of multiple isoforms of AQP4, the single known isoform of AQP9 and for expression of transcription factor HIF1 alpha (sham, probe only control, and PBBI, n = 8-10 per group). Results: Global aqp4 mRNA was decreased at 24 h (p < 0.01) with PBBI. Three of the four known protein isoforms of AQP4 were detected, M1 (34 kDa), M23 (32 kDa) and isoform 3 (30 kDa). AQP4 M1 decreased at 3 and 7 days post-injury (p < 0.001; p < 0.01). AQP4 M23 levels were highly variable with no significant changes. AQP4 isoform 3 levels were decreased 3 days post-PBBI (p < 0.05). From 4, 12, and 24 h aqp9 mRNA levels were decreased with injury (p < 0.01, p < 0.05, p < 0.01) while AQP9 levels were decreased at 3 and 7 days after PBBI (p < 0.001, p < 0.01). At 12 and 24 h post-PBBI hif1 alpha mRNA levels increased (p < 0.05, p < 0.01) but at 3 and 7 days mRNA levels decreased (p < 0.05, p < 0.01). From 24 h and 3 and 7 days HIF1 alpha protein levels were decreased (p < 0.0001, p < 0.0001, p < 0.0001). In comparison to probe control, PBBI led to greater decreases in protein for AQP4 M1 (trend), AQP4 isoform 3 (trend), AQP9 (p < 0.05) and HIFI (p < 0.05). Conclusion: PBBI is characterized by a loss of AQP4 Ml, AQP4 isoform 3 and AQP9 at delayed time-points. The severity of the injury (PBBI versus probe control) increased these effects. Therefore, AQP9 and the AQP4 M1 isoform may be regulated by HIF1 alpha, but not AQP4 isoform 3. This delayed loss of aquaporins may markedly reduce the ability of the brain to efflux water, contributing to the protracted edema that is a characteristic following severe penetrating TBI. Factors contributing to edema differ with different types and severities of TBI. For example, cellular based edema is more prominent in diffuse non-penetrating TBI whereas vasogenic edema is more prevalent with TBI involving hemorrhage. Molecular regulation leading to edema will likely also differ, such that treatments which have been suggested for non-hemorrhagic moderate TBI, such as the suppression of aquaporins, may be detrimental in more severe forms of TBI. Published by Elsevier Inc. C1 [Cartagena, Casandra M.; Phillips, Katie L.; Tortella, Frank C.; Dave, Jitendra R.; Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Cartagena, CM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. EM casandra.m.cartagena.civ@mail.mil; katie.phillips1@us.army.mil; frank.c.tortella.civ@mail.mil; jitendra.r.dave.civ@mail.mil; kara.e.schmid.mil@mail.mil NR 26 TC 6 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1044-7431 EI 1095-9327 J9 MOL CELL NEUROSCI JI Mol. Cell. Neurosci. PD MAY PY 2014 VL 60 BP 81 EP 87 DI 10.1016/j.mcn.2014.04.005 PG 7 WC Neurosciences SC Neurosciences & Neurology GA AI5DX UT WOS:000336886700009 PM 24769105 ER PT J AU Margolis, LM Crombie, AP McClung, HL McGraw, SM Rood, JC Montain, SJ Young, AJ AF Margolis, Lee M. Crombie, Aaron P. McClung, Holly L. McGraw, Susan M. Rood, Jennifer C. Montain, Scott J. Young, Andrew J. TI Energy Requirements of US Army Special Operation Forces During Military Training SO NUTRIENTS LA English DT Article DE military training; doubly labeled water; energy requirements ID DOUBLY-LABELED WATER; PHYSICAL-ACTIVITY; BODY-COMPOSITION; EXPENDITURE; EXERCISE; SOLDIERS; HUMANS; FIELD; GARRISON; MEN AB Special Operations Forces (SOF) regularly engage in physically demanding combat operations and field training exercises, resulting in high daily energy expenditure, and thus increased energy requirements. However, the majority of studies assessing energy requirements of SOF have been conducted on soldiers going through intense SOF initiation training. The objective of the current investigation was to determine the energy expenditure of SOF conducting military training operations. Thirty-one soldiers taking part in Pre-Mission Training (PMT n = 15) and Combat Diver Qualification Courses (CDQC n = 16) volunteered to participate in this observational study. Energy expenditure was determined using doubly labeled water. Body weight (83 7 kg) remained stable during both training periods. Overall energy expenditure adjusted for body composition was 17,606 +/- 2326 kJ center dot day(-1). Energy expenditure was 19,110 +/- 1468 kJ center dot day(-1) during CDQC and 16,334 +/- 2180 kJ center dot day(-1) during PMT, with physical activity levels of 2.6 +/- 0.2 and 2.2 +/- 0.3 during CDQC and PMT, respectively. Compared to the Military Dietary Reference Intakes for energy (13,598 kJ center dot day(-1)), these data are in agreement with previous reports that energy requirement for SOF Soldiers exceed that of the average soldier. C1 [Margolis, Lee M.; Crombie, Aaron P.; McClung, Holly L.; McGraw, Susan M.; Montain, Scott J.; Young, Andrew J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. RP Margolis, LM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM lee.m.margolis.ctr@mail.mil; aaron.p.crombie.mil@mail.mil; holly.l.mcclung.civ@mail.mil; susan.m.mcgraw6.civ@mail.mil; jennifer.rood@pbrc.edu; scott.j.montain.civ@mail.mil; andrew.j.young.ctr@mail.mil OI , Lee/0000-0002-0652-1304 NR 30 TC 3 Z9 3 U1 0 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY PY 2014 VL 6 IS 5 BP 1945 EP 1955 DI 10.3390/nu6051945 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AI8JQ UT WOS:000337160100012 PM 24824290 ER PT J AU Jenkins, DH Rappold, JF Badloe, JF Berseus, O Blackbourne, L Brohi, KH Butler, FK Cap, AP Cohen, MJ Davenport, R DePasquale, M Doughty, H Glassberg, E Hervig, T Hooper, TJ Kozar, R Maegele, M Moore, EE Murdock, A Ness, PM Pati, S Rasmussen, T Sailliol, A Schreiber, MA Sunde, GA van de Watering, LMG Ward, KR Weiskopf, RB White, NJ Strandenes, G Spinella, PC AF Jenkins, Donald H. Rappold, Joseph F. Badloe, John F. Berseus, Olle Blackbourne, Lorne Brohi, Karim H. Butler, Frank K. Cap, Andrew P. Cohen, Mitchell Jay Davenport, Ross DePasquale, Marc Doughty, Heidi Glassberg, Elon Hervig, Tor Hooper, Timothy J. Kozar, Rosemary Maegele, Marc Moore, Ernest E. Murdock, Alan Ness, Paul M. Pati, Shibani Rasmussen, Todd Sailliol, Anne Schreiber, Martin A. Sunde, Geir Arne van De Watering, Leo M. G. Ward, Kevin R. Weiskopf, Richard B. White, Nathan J. Strandenes, Geir Spinella, Philip C. TI TRAUMA HEMOSTASIS AND OXYGENATION RESEARCH POSITION PAPER ON REMOTE DAMAGE CONTROL RESUSCITATION: DEFINITIONS, CURRENT PRACTICE, AND KNOWLEDGE GAPS SO SHOCK LA English DT Article DE Trauma; prehospital; transfusion; mortality; morbidity; resuscitation ID FRESH WHOLE-BLOOD; PLACEBO-CONTROLLED-TRIAL; BLUNT LIVER-INJURY; HEMORRHAGIC-SHOCK; TRANEXAMIC ACID; ACUTE COAGULOPATHY; FROZEN PLASMA; HYPOTENSIVE RESUSCITATION; FIBRINOGEN CONCENTRATE; PATHOGEN REDUCTION AB The Trauma Hemostasis and Oxygenation Research Network held its third annual Remote Damage Control Resuscitation Symposium in June 2013 in Bergen, Norway. The Trauma Hemostasis and Oxygenation Research Network is a multidisciplinary group of investigators with a common interest in improving outcomes and safety in patients with severe traumatic injury. The network's mission is to reduce the risk of morbidity and mortality from traumatic hemorrhagic shock, in the prehospital phase of resuscitation through research, education, and training. The concept of remote damage control resuscitation is in its infancy, and there is a significant amount of work that needs to be done to improve outcomes for patients with life-threatening bleeding secondary to injury. The prehospital phase of resuscitation is critical in these patients. If shock and coagulopathy can be rapidly identified and minimized before hospital admission, this will very likely reduce morbidity and mortality. This position statement begins to standardize the terms used, provides an acceptable range of therapeutic options, and identifies the major knowledge gaps in the field. C1 [Jenkins, Donald H.] Mayo Clin, Dept Surg, Rochester, MN 55905 USA. [Rappold, Joseph F.] Temple Univ, Sch Med, Dept Surg, Philadelphia, PA 19122 USA. [Badloe, John F.] Netherlands Mil Blood Bank, Blood Banking Amer Soc Clin Pathol, Amsterdam, Netherlands. [Berseus, Olle] Orebro Univ Hosp, Dept Transfus Med, SE-70182 Orebro, Sweden. [Blackbourne, Lorne] US Army Inst Surg Res, San Antonio, TX USA. [Brohi, Karim H.] Royal London Hosp, Barts & London Sch Med, London E1 1BB, England. [Brohi, Karim H.] Royal London Hosp, London E1 1BB, England. [Butler, Frank K.] Joint Base San Antonio, Joint Trauma Syst, Comm Tact Combat Casualty Care, San Antonio, TX USA. [Cap, Andrew P.] JBSA Ft Sam Houston, US Army Inst Surg Res, Ft Sam Houston, TX USA. [Cohen, Mitchell Jay] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA. [Davenport, Ross] Queen Mary Univ London, Barts & London Sch Med, Ctr Trauma Sci, Blizard Inst, London, England. [DePasquale, Marc] Deployment Med Int, Gig Harbor, DC USA. [Doughty, Heidi] Transfus Med NHS Blood & Transplant, Birmingham, W Midlands, England. [Glassberg, Elon] Israel Def Forces, Trauma & Combat Med Branch, Surgeon Gen HQ, Ramat Gan, Israel. [Glassberg, Elon] Hebrew Univ Jerusalem, Dept Mil Med, Jerusalem, Israel. [Hervig, Tor] Univ Bergen, Haukeland Univ Hosp, Blood Bank, N-5020 Bergen, Norway. [Hervig, Tor] Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway. [Hooper, Timothy J.] Frenchay Hosp, Dept Anaesthet, UK Def Med Serv, Bristol BS16 1LE, Avon, England. [Kozar, Rosemary] Univ Texas Med Sch Houston, Mem Hermann Hosp, Dept Surg, Houston, TX USA. [Maegele, Marc] Merheim Med Ctr, Dept Traumatol Orthoped Surg & Sportsmed Cologne, Cologne, Germany. [Moore, Ernest E.] Univ Colorado Denver, Dept Surg, Denver, CO USA. [Murdock, Alan] Air Force Med Operat Agcy, Lackland AFB, TX USA. [Murdock, Alan] Univ Pittsburgh, Med Ctr, Div Trauma & Gen Surg, Pittsburgh, PA USA. [Ness, Paul M.] Johns Hopkins Med Inst, Transfus Med Div, Baltimore, MD 21205 USA. [Pati, Shibani] Blood Syst Res Inst, San Francisco, CA USA. [Rasmussen, Todd] Joint Base San Antonio, US Army Inst Surg Res, Ft Sam Houston, TX USA. [Sailliol, Anne] French Mil Blood Transfus Ctr, Clamart, France. [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Sunde, Geir Arne] Norwegian Air Ambulance Fdn, Drobak, Norway. [van De Watering, Leo M. G.] Ctr Clin Transfus Res, Sanquin Blood Supply, Leiden, Netherlands. [Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI USA. [Weiskopf, Richard B.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA. [White, Nathan J.] Univ Washington, Dept Med, Div Emergency Med, Seattle, WA USA. [Strandenes, Geir] Haukeland Hosp, Norwegian Naval Special Operat Commando, N-5021 Bergen, Norway. [Strandenes, Geir] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [van De Watering, Leo M. G.] Washington Univ, Dept Pediat, Div Pediat Crit Care, St Louis, MO 63130 USA. RP Jenkins, DH (reprint author), Mayo Clin, Dept Surg, 200 1st St SW, Rochester, MN 55905 USA. EM jenkins.donald@mayo.edu OI Davenport, Ross/0000-0002-8593-6582 FU TerumoBCT; Entegrion; Octapharma FX Disclosures of interest: P. C. S.: TerumoBCT, Entegrion, Octapharma, grant recipient for NIH/NHLBI, US Department of Defense. E. E. M.: Grant recipient for US Department of Defense. R. D.: Grant recipient for TEM Innovations, Haemonetics. H. D.: UK Defence Medical Services. M. M.: Consultant for Biotest, CSL Behring, LFB, TEM International. P.M.N.: Consultant for TerumoBCT. J.F.R.: US Department of Defense. R. B. W.: NHLBI/NIH, FDA, US DOD, CaridianBCT, CSL-Behring. N.J.W.: National Institutes of Health NCCR-NCATS KL2 TR000421, Washington Life Sciences Discovery Fund, University of Washington Coulter Translational Research Award, and University of Washington Institute for Translational Health Sciences and is and is cofounder, board member, and consultant to Stasys Medical Corp and reports no conflicts of interest related to this work. Travel support for this work was provided by NIH NCCR-NCATS KL2 TR000421. NR 89 TC 34 Z9 35 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2014 VL 41 SU 1 BP 3 EP 12 DI 10.1097/SHK.0000000000000140 PG 10 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6EX UT WOS:000336965100002 PM 24430539 ER PT J AU Pidcoke, HF Spinella, PC Ramasubramanian, AK Strandenes, G Hervig, T Ness, PM Cap, AP AF Pidcoke, Heather F. Spinella, Philip C. Ramasubramanian, Anand K. Strandenes, Geir Hervig, Tor Ness, Paul M. Cap, Andrew P. TI REFRIGERATED PLATELETS FOR THE TREATMENT OF ACUTE BLEEDING: A REVIEW OF THE LITERATURE AND REEXAMINATION OF CURRENT STANDARDS SO SHOCK LA English DT Review DE Cold platelets; severe hemorrhage; acute hemorrhage; hypoproliferative thrombocytopenia; trauma; platelet storage temperature; damage control resuscitation; massive transfusion protocols ID FRESH WHOLE-BLOOD; TRAUMA PATIENTS; HEMOSTATIC EFFECTIVENESS; APHERESIS PLATELETS; IMPROVED SURVIVAL; INCREASED PLASMA; TRANSFUSION; STORAGE; TEMPERATURE; 22-DEGREES-C AB This review is a synopsis of the decisions that shaped global policy on platelet (PLT) storage temperature and a focused appraisal of the literature on which those discussions were based. We hypothesize that choices were centered on optimization of preventive PLT transfusion strategies, possibly to the detriment of the therapeutic needs of acutely bleeding patients. Refrigerated PLTs are a better hemostatic product, and they are safer in that they are less prone to bacterial contamination. They were abandoned during the 1970s because of the belief that clinically effective PLTs should both be hemostatically functional and survive in circulation for several days as indicated for prophylactic transfusion; however, clinical practice may be changing. Data from two randomized controlled trials bring into question the concept that stable autologous stem cell transplant patients with hypoproliferative thrombocytopenia should continue to receive prophylactic transfusions. At the same time, new findings regarding the efficacy of cold PLTs and their potential role in treating acute bleeding have revived the debate regarding optimal PLT storage temperature. In summary, a "one-size-fits-all'' strategy for PLT storage may not be adequate, and a reexamination of whether cold-stored PLTs should be offered as a widely available therapeutic product may be indicated. C1 [Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, Dept Crit Care, St Louis, MO 63130 USA. [Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Strandenes, Geir; Hervig, Tor] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Ness, Paul M.] Johns Hopkins Univ Hosp, Div Transfus Med, Dept Pathol, Baltimore, MD 21287 USA. RP Cap, AP (reprint author), US Army Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA. EM andrew.p.cap.mil@mail.mil NR 43 TC 21 Z9 21 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2014 VL 41 SU 1 BP 51 EP 53 DI 10.1097/SHK.0000000000000078 PG 3 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6EX UT WOS:000336965100011 PM 24662779 ER PT J AU Reddoch, KM Pidcoke, HF Montgomery, RK Fedyk, CG Aden, JK Ramasubramanian, AK Cap, AP AF Reddoch, Kristin M. Pidcoke, Heather F. Montgomery, Robbie K. Fedyk, Chriselda G. Aden, James K. Ramasubramanian, Anand K. Cap, Andrew P. TI HEMOSTATIC FUNCTION OF APHERESIS PLATELETS STORED AT 4 degrees C AND 22 degrees C SO SHOCK LA English DT Article DE Hemostasis; coagulation; aggregation; clot strength; cold storage; activation ID CHILLED BLOOD-PLATELETS; IN-VITRO; BUFFY-COAT; STORAGE-TEMPERATURE; SHAPE CHANGE; WHOLE-BLOOD; TRANSFUSION; ACTIVATION; AGGREGATION; RECEPTORS AB Introduction: Platelet refrigeration decreases the risk of bacterial contamination and may preserve function better than standard-of-care room temperature (RT) storage. Benefits could include lower transfusion-related complications, decreased costs, improved hemostasis in acutely bleeding patients, and extended shelf life. In this study, we compared the effects of 22 degrees C and 4 degrees C storage on the functional and activation status of apheresis platelets. Methods: Apheresis platelets (n = 5 per group) were stored for 5 days at 22 degrees C with agitation (RT) versus at 4 degrees C with agitation (4 degrees C + AG) and without (4 degrees C). Measurements included platelet counts, mean platelet volume, blood gas analytes, aggregation response, thromboelastography, thromboxane B-2 and soluble CD40 ligand release, activation markers, and microparticle formation. Results: Sample pH levels were within acceptable limits for storage products (pH 6.2-7.4). Platelet glucose metabolism (P < 0.05), aggregation response (adenosine diphosphate: RT 0; 4 degrees C + AG 5.0 +/- 0.8; 4 degrees C 5.6 +/- 0.9; P < 0.05), and clot strength (maximum amplitude: RT 58 +/- 2; 4 degrees C + AG 63 +/- 2; 4 degrees C 67 +/- 2; P < 0.05) were better preserved at 4 degrees C compared with RT storage. Refrigerated samples were more activated compared with RT (P < 0.05), although thromboxane B-2 (P < 0.05) and soluble CD40 ligand release (P < 0.05) were higher at RT. Agitation did not improve the quality of 4 degrees C-stored samples. Conclusions: Apheresis platelets stored at 4 degrees C maintain more viable metabolic characteristics, are hemostatically more effective, and release fewer proinflammatory mediators than apheresis platelets stored at RT over 5 days. Given the superior bacteriologic safety of refrigerated products, these data suggest that cold-stored platelets may improve outcomes for acutely bleeding patients. C1 [Reddoch, Kristin M.; Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA. [Pidcoke, Heather F.; Montgomery, Robbie K.; Fedyk, Chriselda G.; Aden, James K.; Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Ramasubramanian, AK (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA. EM anand.ramasubramanian@utsa.edu; andrew.p.cap.mil@mail.mil FU US Army Medical Research and Materiel Command; National Institutes of Health (NIGMS MBRS-RISE) [GM060655] FX Support was received from the US Army Medical Research and Materiel Command and National Institutes of Health (NIGMS MBRS-RISE GM060655) NR 57 TC 29 Z9 29 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2014 VL 41 SU 1 BP 54 EP 61 DI 10.1097/SHK.0000000000000082 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6EX UT WOS:000336965100012 PM 24169210 ER PT J AU Strandenes, G Berseus, O Cap, AP Hervig, T Reade, M Prat, N Sailliol, A Gonzales, R Simon, CD Ness, P Doughty, HA Spinella, PC Kristoffersen, EK AF Strandenes, Geir Berseus, Olle Cap, Andrew P. Hervig, Tor Reade, Michael Prat, Nicolas Sailliol, Anne Gonzales, Richard Simon, Clayton D. Ness, Paul Doughty, Heidi A. Spinella, Philip C. Kristoffersen, Einar K. TI LOW TITER GROUP O WHOLE BLOOD IN EMERGENCY SITUATIONS SO SHOCK LA English DT Article DE Whole blood; ABO-titers; universal blood; blood transfusion; damage control resuscitation ID DAMAGE CONTROL RESUSCITATION; ABO-INCOMPATIBLE PLASMA; APHERESIS PLATELETS; TRAUMA PATIENTS; IMPROVED SURVIVAL; ANTI-A; TRANSFUSION; HEMOLYSIS; AFGHANISTAN; ANTIBODIES AB In past and ongoing military conflicts, the use of whole blood (WB) as a resuscitative product to treat trauma-induced shock and coagulopathy has been widely accepted as an alternative when availability of a balanced component-based transfusion strategy is restricted or lacking. In previous military conflicts, ABO group O blood from donors with low titers of anti-A/B blood group antibodies was favored. Now, several policies demand the exclusive use of ABO group-specific WB. In this short review, we argue that the overall risks, dangers, and consequences of "the ABO group-specific approach,'' in emergencies, make the use of universal group O WB from donors with low titers of anti-A/B safer. Generally, risks with ABO group-specific transfusions are associated with in vivo destruction of the red blood cells transfused. The risk with group O WB is from the plasma transfused to ABO-incompatible patients. In the civilian setting, the risk of clinical hemolytic transfusion reactions (HTRs) due to ABO group-specific red blood cell transfusions is relatively low (approximately 1: 80,000), but the consequences are frequently severe. Civilian risk of HTRs due to plasma incompatible transfusions, using titered donors, is approximately 1: 120,000 but usually of mild to moderate severity. Emergency settings are often chaotic and resource limited, factors well known to increase the potential for human errors. Using ABO group-specific WB in emergencies may delay treatment because of needed ABO typing, increase the risk of clinical HTRs, and increase the severity of these reactions as well as increase the danger of underresuscitation due to lack of some ABO groups. When the clinical decision has been made to transfuse WB in patients with life-threatening hemorrhagic shock, we recommend the use of group O WB from donors with low anti-A/B titers when logistical constraints preclude the rapid availability of ABO groupYspecific WB and reliable group matching between donor and recipient is not feasible. C1 [Strandenes, Geir; Hervig, Tor; Kristoffersen, Einar K.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Berseus, Olle] Orebro Univ Hosp, Dept Transfus Med, Orebro, Sweden. [Cap, Andrew P.; Prat, Nicolas; Spinella, Philip C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Hervig, Tor; Kristoffersen, Einar K.] Univ Bergen, Inst Clin Sci, N-5020 Bergen, Norway. [Reade, Michael] Australian Def Force Joint Hlth Command, Canberra, ACT, Australia. [Prat, Nicolas] French Mil Med Serv, Clamart, France. [Sailliol, Anne] Commander French Mil Blood Transfus Ctr, Clamart, France. [Gonzales, Richard] Surg Gen San Antonio Mil Med Ctr, US Army Blood Program, Jbsa Ft Sam Houston, TX USA. [Simon, Clayton D.] Surg Gen San Antonio Mil Med Ctr, US Army Transfus Med, Jbsa Ft Sam Houston, TX USA. [Ness, Paul] Johns Hopkins Med Inst, Transfus Med Div, Baltimore, MD 21205 USA. [Doughty, Heidi A.] NHS Blood & Transplant, Birmingham, W Midlands, England. [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Pediat Crit Care, St Louis, MO 63130 USA. RP Strandenes, G (reprint author), Haukeland Hosp, Dept Immunol & Transfus Med, Jonas Liesvei 65, N-5021 Bergen, Norway. EM geir@docfish.no RI PRAT, Nicolas/R-4213-2016; OI Reade, Michael/0000-0003-1570-0707 NR 48 TC 16 Z9 16 U1 4 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2014 VL 41 SU 1 BP 70 EP 75 DI 10.1097/SHK.0000000000000150 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6EX UT WOS:000336965100014 PM 24569505 ER PT J AU Strandenes, G De Pasquale, M Cap, AP Hervig, TA Kristoffersen, EK Hickey, M Cordova, C Berseus, O Eliassen, HS Fisher, L Williams, S Spinella, PC AF Strandenes, Geir De Pasquale, Marc Cap, Andrew P. Hervig, Tor A. Kristoffersen, Einar K. Hickey, Matthew Cordova, Christopher Berseus, Olle Eliassen, Hakon S. Fisher, Logan Williams, Steve Spinella, Philip C. TI EMERGENCY WHOLE-BLOOD USE IN THE FIELD: A SIMPLIFIED PROTOCOL FOR COLLECTION AND TRANSFUSION SO SHOCK LA English DT Article DE Shock; prehospital; remote; damage control; trauma; combat ID IMPROVED SURVIVAL; PLATELETS; PLASMA; PRODUCTS AB Military experience and recent in vitro laboratory data provide a biological rationale for whole-blood use in the treatment of exsanguinating hemorrhage and have renewed interest in the reintroduction of fresh whole blood and cold-stored whole blood to patient care in austere environments. There is scant evidence to support, in a field environment, that a whole bloodYbased resuscitation strategy is superior to a crystalloid/colloid approach even when augmented by a limited number of red blood cell (RBC) and plasma units. Recent retrospective evidence suggests that, in this setting, resuscitation with a full compliment of RBCs, plasma, and platelets may offer an advantage, especially under conditions where evacuation is delayed. No current evacuation system, military or civilian, is capable of providing RBC, plasma, and platelet units in a prehospital environment, especially in austere settings. As a result, for the vast minority of casualties, in austere settings, with life-threatening hemorrhage, it is appropriate to consider a whole bloodYbased resuscitation approach to provide a balanced response to altered hemostasis and oxygen debt, with the goal of reducing the risk of death from hemorrhagic shock. To optimize the successful use of fresh whole blood/cold-stored whole blood in combat field environments, proper planning and frequent training to maximize efficiency and safety will be required. Combat medics will need proper protocol-based guidance and education if whole-blood collection and transfusion are to be successfully and safely performed in austere environments. In this article, we present the Norwegian Naval Special Operation Commando unitYspecific remote damage control resuscitation protocol, which includes field collection and transfusion of whole blood. This protocol can serve as a template for others to use and adjust for their own military or civilian unitYspecific needs and capabilities for care in austere environments. C1 [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Strandenes, Geir; Hervig, Tor A.; Kristoffersen, Einar K.; Eliassen, Hakon S.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Strandenes, Geir; Hervig, Tor A.; Kristoffersen, Einar K.; Eliassen, Hakon S.] Univ Bergen, Inst Clin Sci, Bergen, Norway. [De Pasquale, Marc] Deployment Med Int, Gig Harbor, WA USA. [Cap, Andrew P.; Spinella, Philip C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Hickey, Matthew] Naval Special Warfare Command, San Diego, CA USA. [Cordova, Christopher] US Army, Keller Army Community Hosp, Specialist Corps, West Point, NY USA. [Berseus, Olle] Orebro Univ Hosp, Dept Transfus Med, Orebro, Sweden. [Fisher, Logan] NSWDG US Navy, Virginia Beach, VA USA. [Williams, Steve] Med Operat Royal Caribbean Cruises Ltd, St Louis, MO USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA. RP Strandenes, G (reprint author), Helse Bergen Haukeland Univ Hosp, Bergen, Norway. EM geir@docfish.no NR 21 TC 20 Z9 20 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2014 VL 41 SU 1 BP 76 EP 83 DI 10.1097/SHK.0000000000000114 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6EX UT WOS:000336965100015 PM 24365879 ER PT J AU Gandhi, F Duling, C Straub, F AF Gandhi, F. Duling, C. Straub, F. TI On power and actuation requirement in swashplateless primary control of helicopters using trailing-edge flapes SO AERONAUTICAL JOURNAL LA English DT Article ID MACH-SCALED ROTOR AB This paper examines three specific aspects pertaining to the trailing-edge flap (TEF) enabled swashplateless primary control of a helicopter. The study is based on a utility helicopter very similar to the UH-60A Blackhawk helicopter, with rotor torsion frequency reduced to 2.1/rev, and 20% chord TEFs extending from 70-90% span. The questions addressed in the paper are the power penalty due to aerodynamic drag associated with TEF control, the pitch-index required to limit the range of TEF deflections over variations in aircraft gross-weight and airspeed, and the influence of rotor RPM variation on swashplateless primary control. Results indicate that the power penalty associated with TEF enabled primary control at high speeds is in the range of 6-7%, due to increased drag on the advancing side in the region of the TEFs and at the blade tips. At low to moderate speeds the increase in power is 2-4% on average, more dependent on the pitch-index, and due to drag increase over most of the azimuth in the region of the TEFs. A variation in pitch-index from 16 degrees for lower speeds and gross weights, to 20-22 degrees for higher speeds and gross weights, would reduce the steady level flight TEF deflection requirements to under +/- 3 degrees, leaving sufficient control margin. Increase in rotor RPM does not increase directly increase thrust (as with a stiff-torsion rotor) but reduces the rotating torsion frequency, and together with the increased dynamic pressures increases the sensitivity to TEF control. At low to moderate speeds a 9% increase in RPM reduces the maximum TEF deflections required by about 1 degrees, but is accompanied by a large increase in rotor power. Conversely, a 9% RPM reduction decreases rotor power required, but the TEF deflections required increase by 1-1-5 degrees. C1 [Gandhi, F.] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Duling, C.] US Army, Ft Campbell, KY USA. [Straub, F.] Boeing Co, Mesa, AZ USA. RP Gandhi, F (reprint author), Rensselaer Polytech Inst, Troy, NY 12180 USA. EM fgandhi@rpi.edu FU Center for Rotorcraft Innovation (CRI); National Rotorcraft Technology Center (NRTC); US Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) under Technology Investment Agreement [W911W6-06-2-0002]; National Rotorcraft Technology Center Research Program FX This work was performed under the project 'Hub Concepts for Swashplateless Rotors,' funded by the Center for Rotorcraft Innovation (CRI) and the National Rotorcraft Technology Center (NRTC), US Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) under Technology Investment Agreement W911W6-06-2-0002, entitled National Rotorcraft Technology Center Research Program. The authors would like to acknowledge that this research and development was accomplished with the support and guidance of the NRTC and CRI. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the AMRDEC or the US Government. The US Government is authorised to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. NR 20 TC 0 Z9 0 U1 0 U2 3 PU ROYAL AERONAUTICAL SOC PI LONDON PA 4 HAMILTON PL, LONDON W1J 7BQ, ENGLAND SN 0001-9240 J9 AERONAUT J JI Aeronaut. J. PD MAY PY 2014 VL 118 IS 1203 BP 503 EP 521 PG 19 WC Engineering, Aerospace SC Engineering GA AI0RX UT WOS:000336558700003 ER PT J AU Damiano, L Jambeck, JR Ringelberg, DB AF Damiano, Lisa Jambeck, Jenna R. Ringelberg, David B. TI Municipal Solid Waste Landfill Leachate Treatment and Electricity Production Using Microbial Fuel Cells SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article DE Landfill leachate; Leachate treatment; Municipal solid waste; MFC ID POWER-GENERATION; WATER; REMOVAL; ANODES; MICROORGANISMS; TECHNOLOGY; MEMBRANE AB Microbial fuel cells were designed and operated to treat landfill leachate while simultaneously producing electricity. Two designs were tested in batch cycles using landfill leachate as a substrate without inoculation (908 to 3,200 mg/L chemical oxygen demand (COD)): Circle (934 mL) and large-scale microbial fuel cells (MFC) (18.3 L). A total of seven cycles were completed for the Circle MFC and two cycles for the larger-scale MFC. Maximum power densities of 24 to 31 mW/m(2) (653 to 824 mW/m(3)) were achieved using the Circle MFC, and a maximum voltage of 635 mV was produced using the larger-scale MFC. In the Circle MFC, COD, biological oxygen demand (BOD), total organic carbon (TOC), and ammonia were removed at an average of 16%, 62%, 23%, and 20%, respectively. The larger-scale MFC achieved an average of 74% BOD removal, 27% TOC removal, and 25% ammonia reduction while operating over 52 days. Analysis of the microbial characteristics of the leachate indicates that there might be both supportive and inhibiting bacteria in landfill leachate for operation of an MFC. Issues related to scale-up and heterogeneity of a mixed substrate remain. C1 [Damiano, Lisa] Univ New Hampshire, Durham, NH 03824 USA. [Jambeck, Jenna R.] Univ Georgia, Athens, GA 30602 USA. [Ringelberg, David B.] US Army ERDC CRREL, Hanover, NH 03755 USA. RP Jambeck, JR (reprint author), Univ Georgia, Athens, GA 30602 USA. EM jjambeck@uga.edu FU Environmental Research and Education Foundation FX The authors acknowledge the donation of Waste Management's Turnkey Landfill leachate for this work and the Environmental Research and Education Foundation for funding this research. NR 36 TC 13 Z9 15 U1 12 U2 86 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0273-2289 EI 1559-0291 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD MAY PY 2014 VL 173 IS 2 BP 472 EP 485 DI 10.1007/s12010-014-0854-x PG 14 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA AH9VF UT WOS:000336492000011 PM 24671566 ER PT J AU Hahs, DW Corron, NJ Blakely, JN AF Hahs, Daniel W. Corron, Ned J. Blakely, Jonathan N. TI Synthesizing antipodal chaotic waveforms SO JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS LA English DT Article ID CARDIAC ALTERNANS; DYNAMIC CONTROL; COMMUNICATION; SYSTEMS AB Chaotic waveforms are natural information carriers since a correspondence can be established between the symbolic dynamics of a chaotic oscillator and the symbols of a message. Message symbols can be efficiently encoded in a chaotic waveform by applying vanishingly small perturbations to an oscillator to guide its symbolic dynamics to follow a desired course. Recently, two chaotic hybrid dynamical systems were shown to have matched filters enabling robust reception of chaotic communication waveforms in the presence of noise. The first of these, the exact shift oscillator, produces waveforms with desirable properties similar to antipodal signaling, but a physical implementation may be difficult to control using small perturbations. The second oscillator, the exact folded-band oscillator, produces less optimal waveforms but is more easily controlled. Here we introduce a method for generating waveforms of the exact shift oscillator by summing waveforms from a bank of easily controlled exact folded-band oscillators. We show that any solution of the exact shift oscillator can be so constructed using only three folded-band oscillators. Thus, this scheme allows us to realize the advantages of both chaotic systems while overcoming their individual disadvantages, thereby enabling practical chaos communications. Published by Elsevier Ltd. on behalf of The Franklin Institute. C1 [Hahs, Daniel W.] Torch Technol Inc, Huntsville, AL 35801 USA. [Corron, Ned J.; Blakely, Jonathan N.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, Charles M Bowden Lab, Huntsville, AL 35898 USA. RP Blakely, JN (reprint author), US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, Charles M Bowden Lab, Huntsville, AL 35898 USA. EM jonathan.blakely@us.army.mil OI Corron, Ned/0000-0002-3232-5024 NR 19 TC 3 Z9 3 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-0032 EI 1879-2693 J9 J FRANKLIN I JI J. Frankl. Inst.-Eng. Appl. Math. PD MAY PY 2014 VL 351 IS 5 BP 2562 EP 2573 DI 10.1016/j.jfranklin.2013.12.014 PG 12 WC Automation & Control Systems; Engineering, Multidisciplinary; Engineering, Electrical & Electronic; Mathematics, Interdisciplinary Applications SC Automation & Control Systems; Engineering; Mathematics GA AH9NY UT WOS:000336470300009 ER PT J AU Sipos, ML Foran, HM Wood, MD Wright, KM Barnhart, VJ Riviere, LA Adler, AB AF Sipos, Maurice L. Foran, Heather M. Wood, Michael D. Wright, Kathleen M. Barnhart, Vincent J. Riviere, Lyndon A. Adler, Amy B. TI Assessment of an Alternative Postdeployment Reintegration Strategy With Soldiers Returning From Iraq SO PSYCHOLOGICAL SERVICES LA English DT Article DE behavioral health; alcohol; aggression; risk behavior; deployment reintegration ID MENTAL-HEALTH PROBLEMS; COMBAT; AFGHANISTAN; PREVALENCE; DEPLOYMENT; BEHAVIORS; CHECKLIST; COMPONENT; VETERANS; CARE AB The present study examined behavioral health outcomes, risk behaviors, aggression, alcohol misuse, marital satisfaction, and attitudes toward reintegration associated with an alternative, front-loaded reintegration strategy compared with a more standardized reintegration process in soldiers returning from combat deployments. The type of reintegration strategy used did not predict differences in posttraumatic stress disorder (PTSD) symptoms, alcohol misuse, aggression, and marital satisfaction, although slightly higher reports of risk behaviors were found in the unit using the standard reintegration approach even after controlling for demographic covariates and combat exposure. These findings may help guide leadership when making decisions regarding reintegration approaches in the future. C1 [Sipos, Maurice L.; Foran, Heather M.; Wood, Michael D.; Wright, Kathleen M.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Barnhart, Vincent J.] Evans Army Community Hosp, Dept Med Readiness, Ft Carson, CO USA. [Riviere, Lyndon A.] Walter Reed Army Inst Res, Mil Psychiat Branch, Silver Spring, MD 20910 USA. RP Sipos, ML (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM maurice.sipos@us.army.mil NR 27 TC 0 Z9 0 U1 1 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2014 VL 11 IS 2 BP 185 EP 191 DI 10.1037/a0033308 PG 7 WC Psychology, Clinical SC Psychology GA AI3TC UT WOS:000336784900008 PM 24079352 ER PT J AU Kelley, CL Britt, TW Adler, AB Bliese, PD AF Kelley, Christie L. Britt, Thomas W. Adler, Amy B. Bliese, Paul D. TI Perceived Organizational Support, Posttraumatic Stress Disorder Symptoms, and Stigma in Soldiers Returning From Combat SO PSYCHOLOGICAL SERVICES LA English DT Article DE perceived organizational support; stigma; symptoms ID MENTAL-HEALTH PROBLEMS; NATIONAL-GUARD SOLDIERS; GULF-WAR; BARRIERS; IRAQ; CARE; EXPOSURE; SATISFACTION; AFGHANISTAN; COMMITMENT AB Research has shown that perceived organizational support (POS), or how much employees believe their organizations value their contributions and well-being, is an important predictor of employee mental health outcomes. To support employee mental health in high-risk occupations, organizations may want to identify variables that explain the relationship between POS and posttraumatic stress disorder (PTSD). Using a longitudinal design and a military sample, the present study found a relationship between POS and stigma as well as PTSD symptoms. Stigma partially mediated the relationship between POS at Time 1 and PTSD symptoms at Time 2. The partial mediation indicates that a supportive environment may also create a climate of reduced stigma in which soldiers may be comfortable addressing PTSD symptoms. Both results suggest positive actions that organizations can take to support employee mental health. C1 [Kelley, Christie L.; Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29631 USA. [Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Silver Spring, MD USA. [Bliese, Paul D.] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD USA. RP Kelley, CL (reprint author), 4631 1-2 Clarissa Ave, Los Angeles, CA 90027 USA. EM christie.lynn.kelley@gmail.com NR 41 TC 5 Z9 5 U1 4 U2 19 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2014 VL 11 IS 2 BP 229 EP 234 DI 10.1037/a0034892 PG 6 WC Psychology, Clinical SC Psychology GA AI3TC UT WOS:000336784900013 PM 24364593 ER PT J AU Roach, CJ Haley, CA Cameron, KL Pallis, M Svoboda, SJ Owens, BD AF Roach, Christopher J. Haley, Chad A. Cameron, Kenneth L. Pallis, Mark Svoboda, Steven J. Owens, Brett D. TI The Epidemiology of Medial Collateral Ligament Sprains in Young Athletes SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE knee injuries; risk factor; epidemiology; medial collateral ligament ID ICE HOCKEY INJURIES; KNEE INJURIES; COLLEGE FOOTBALL; SKIING INJURIES; SPORTS; TEAM; LEAGUE; BRACE; RATES; RISK AB Background: A medial collateral ligament (MCL) knee sprain is a prevalent injury in athletic populations that may result in significant time lost to injury. Remarkably little is known of the epidemiology of this injury. Purpose: To define the incidence of MCL tears and to determine the demographic and athletic risk factors. Study Design: Descriptive epidemiological study. Methods: A longitudinal cohort study was performed to examine the epidemiology of isolated MCL sprains at the United States Military Academy (USMA) between 2005 and 2009. Charts and radiographic studies were reviewed by an independent orthopaedic surgeon to identify all new isolated MCL sprains resulting in time lost to sport and activity that occurred within the study period. Incidence rates (IRs) with 95% confidence intervals (CIs) were calculated per 1000 person-years at risk and by sex, sport, and level of competition. The IR per 1000 athlete-exposures (AEs) was also determined. Incidence rate ratios (IRRs) and respective 95% CIs were calculated between male and female students, intercollegiate and intramural athletes, and male and female intercollegiate athletes involved in selected sports. Chi-square and Poisson regression analyses were used to examine the relationship between the variables of interest and the incidence of MCL sprains, with statistical significance set at P < .05. Results: A total of 128 cadets sustained isolated MCL injuries during 17,606 student person-years from 2005 to 2009. This resulted in an IR of approximately 7.3 per 1000 person-years. Of the 128 injuries, 114 were in male athletes (89%) and 14 were in female athletes (11%). Male cadets had a 44% higher IR than did female cadets (7.60 vs 5.36, respectively), although this was not significant (P = .212). Of 5820 at-risk intercollegiate athletes, 59 (53 male, 6 female) sustained an isolated MCL sprain during 528,523 (407,475 male, 121,048 female) AEs for an overall IR of 10.14 per 1000 person-years and 0.11 per 1000 AEs. The IRR of MCL sprains of men compared with women involved in intercollegiate athletics was 2.87 (95% CI, 1.24-8.18) per 1000 person-years and 2.62 (95% CI, 1.13-7.47) per 1000 AEs. Of 21,805 at-risk intramural athletes, with quarterly participation, 16 (all male) sustained isolated MCL injuries during 225,683 AEs for an overall IR of 0.07 per 1000 AEs. The IRs of MCL injuries of intercollegiate and intramural athletes did not differ significantly. In intercollegiate sports, wrestling (0.57), judo (0.36), hockey (0.34), and rugby (men's, 0.22; women's, 0.23) had the highest IRs per 1000 AEs. When examining men's intercollegiate athletics, the IRRs of wrestling (13.41; 95% CI, 1.80-595.27) and hockey (8.12; 95% CI, 0.91-384.16) were significantly higher compared with that of lacrosse. Among women's intercollegiate sports as well as intramural sports, there were no significant differences in IRs. A median of 16 days was lost to injury, with 2407 total days lost for all injuries. Grade 1 MCL injuries lost a median of 13.5 days, while higher grade injuries lost a median of 29 days. Conclusion: Medial collateral ligament injuries are relatively common in athletic cohorts. The most injurious sports are contact sports such as wrestling, hockey, judo, and rugby. Male athletes are at a greater risk than female athletes. Intercollegiate athletes are at a greater risk than intramural athletes. The average amount of time lost per injury was 23.2 days, with greater time lost with higher grade sprains than grade 1 sprains. C1 [Roach, Christopher J.; Haley, Chad A.; Cameron, Kenneth L.; Pallis, Mark; Svoboda, Steven J.; Owens, Brett D.] US Mil Acad, Dept Orthoped Surg, Keller Army Hosp, West Point, NY 10996 USA. RP Roach, CJ (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Roger Brooke Dr, San Antonio, TX 78234 USA. EM christopher.roach@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 35 TC 7 Z9 7 U1 10 U2 36 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY PY 2014 VL 42 IS 5 BP 1103 EP 1109 DI 10.1177/0363546514524524 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AG6ZM UT WOS:000335567700010 PM 24603529 ER PT J AU Mayercsik, NP Felice, R Ley, MT Kurtis, KE AF Mayercsik, Nathan P. Felice, Robert Ley, M. Tyler Kurtis, Kimberly E. TI A probabilistic technique for entrained air void analysis in hardened concrete SO CEMENT AND CONCRETE RESEARCH LA English DT Article DE Characterization (B); Image analysis (B); Microstructure (B); Durability (C); Freezing and thawing (C) ID FLAT-BED SCANNER AB A novel method that utilizes the lineal-path function to ascertain a probability density function for the three-dimensional size distribution of entrained air voids directly from plane polished sections of hardened concrete is proposed. The results then treat the sparing factor in terms of a probabilistic maximum distance from a random point in the cement paste matrix to the periphery of an air void, where air voids are treated as a polydispersed sphere system. The model was applied to concretes with various air entrainment admixture types and dosages. The results suggest that the model may offer a better assessment of the system for use in assessing durability and studying admixtures, as well as providing a new tool for spatial characterization of heterogeneous and porous materials. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Mayercsik, Nathan P.; Kurtis, Kimberly E.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. [Felice, Robert] US Army Corps Engn, Tulsa, OK 74128 USA. [Ley, M. Tyler] Oklahoma State Univ, Sch Civil & Environm Engn, Stillwater, OK 74078 USA. RP Kurtis, KE (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, 790 Atlantic Dr, Atlanta, GA 30332 USA. EM kkurtis@ce.gatech.edu OI Kurtis, Kimberly/0000-0002-1252-7323 FU NSF [CMMI-0970049]; Concrete Pavement Technology Center; Oklahoma Transportation Center FX This work was supported by NSF Grant CMMI-0970049, and by grants from the Concrete Pavement Technology Center and the Oklahoma Transportation Center. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the sponsor. The authors would like to acknowledge the assistance of undergraduate students Jaymie Kaiser and Xenia Strosnider. NR 33 TC 10 Z9 10 U1 3 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-8846 EI 1873-3948 J9 CEMENT CONCRETE RES JI Cem. Concr. Res. PD MAY PY 2014 VL 59 BP 16 EP 23 DI 10.1016/j.cemconres.2014.01.023 PG 8 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA AH7XY UT WOS:000336349900002 ER PT J AU Brame, JA Kennedy, AJ Lounds, CD Bednar, AJ Alvarez, PJJ Scott, AM Stanley, JK AF Brame, Jonathon A. Kennedy, Alan J. Lounds, Christopher D. Bednar, Anthony J. Alvarez, Pedro J. J. Scott, Andrea M. Stanley, Jacob K. TI INFLUENCE OF CARBON AND METAL OXIDE NANOMATERIALS ON AQUEOUS CONCENTRATIONS OF THE MUNITION CONSTITUENTS CYCLOTRIMETHYLENETRINITRAMINE (RDX) AND TUNGSTEN SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nanomaterial; Environmental fate; Munitions constituent; Military; Adsorption ID TITANIUM-DIOXIDE NANOPARTICLES; ACTIVATED CARBON; ORGANIC-MATTER; ALUMINUM-OXIDE; NANOTUBES; ADSORPTION; SORPTION; NANO; REMOVAL; BIOACCUMULATION AB There is an increasing likelihood of interactions between nanomaterials and munitions constituents in the environment resulting from the use of nanomaterials as additives to energetic formulations and potential contact in waste streams from production facilities and runoff from training ranges. The purpose of the present research was to determine the ability of nano-aluminum oxide (Al2O3) and multiwalled carbon nanotubes (MWCNTs) to adsorb the munitions constituents cyclotrimethylenetrinitramine (RDX) and tungsten (W) from aqueous solution as a first step in determining the long-term exposure, transport, and bioavailability implications of such interactions. The results indicate significant adsorption of RDX by MWCNTs and of W by nano-Al2O3 (but not between W and MWCNT or RDX and nano-Al2O3). Kinetic sorption and desorption investigations indicated that the most sorption occurs nearly instantaneously (<5min), with a relatively slower, secondary binding leading to statistically significant but relatively smaller increases in adsorption over 30 d. The RDX sorption that occurred during the initial interaction was irreversible, with long-term, reversible sorption likely the result of a secondary interaction; as interaction time increased, however, the portion of W irreversibly sorbed onto nano-Al2O3 also increased. The present study shows that strong interactions between some munitions constituents and nanomaterials following environmental release are likely. Time-dependent binding has implications for the bioavailability, migration, transport, and fate of munitions constituents in the environment. Environ Toxicol Chem 2014;33:1035-1042. (c) 2014 SETAC C1 [Brame, Jonathon A.; Kennedy, Alan J.; Bednar, Anthony J.; Scott, Andrea M.; Stanley, Jacob K.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Brame, Jonathon A.; Alvarez, Pedro J. J.] Rice Univ, Houston, TX USA. [Lounds, Christopher D.] Badger Tech Serv, Vicksburg, MS USA. RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil FU Army's Environmental Quality Technology Basic Research Program FX Permission was granted by the Chief of Engineers to publish this material. This work was supported by the Army's Environmental Quality Technology Basic Research Program (Dr. E. Ferguson, Technical Director). The authors thank N.E. Harms and P. Chappell for their contributions to the sorption and desorption experiments and A. Harmon and C. Detzel for characterization assistance. NR 55 TC 0 Z9 0 U1 5 U2 22 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 2014 VL 33 IS 5 BP 1035 EP 1042 DI 10.1002/etc.2531 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AF1QP UT WOS:000334488700012 PM 24464681 ER PT J AU Lairet, KF Baer, D Leas, ML Renz, EM Cancio, LC AF Lairet, Kimberly F. Baer, David Leas, Michelle L. Renz, Evan M. Cancio, Leopoldo C. TI Evaluation of an Oxygen-Diffusion Dressing for Accelerated Healing of Donor-Site Wounds SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article AB Accelerating the healing process and reducing pain during healing are beneficial for the following reasons: faster return to work, lower risk of wound infection, improved quality of life, and possibly reduced need for analgesia. This clinical study assessed the effectiveness of a new oxygen-diffusion dressing (OxyBand; Oxyband Technologies, St. Louis, MO) compared with standard Xeroform gauze dressings (Convidien, Mansfield, MA), in the care of skin-graft donor sites in burn patients. Time to healing was the primary endpoint, and pain scores and cosmetic outcome were also assessed. This was a prospective, randomized, controlled study of burn patients undergoing harvesting of two donor sites. Patients were followed at predetermined time points for 30 to 45 days to determine the time to reepithelialization, cosmetic appearance, and pain. Subjects were adult burn patients with less than 30% TBSA burns admitted to the burn center, who required excision and grafting. Twenty patients were enrolled, of whom 17 completed the study. Average age was 35 years. Average burn size was 9.2% TBSA. Patients underwent harvesting of split-thickness skin grafts with one donor wound dressed with OxyBand and the other dressed in Xeroform gauze. Wounds were inspected and photographed on postoperative days 4 and 8, and then every 2 days until the donor wounds were healed. Pain scores at each site were also collected at these visits (rated by patients on a scale from 0 to 10). Mean time to wound healing for OxyBand was 9.3 +/- 1.7 days; for Xeroform, 12.4 +/- 2.7 days (P < .001). Pain scores were lower (P < .01) at the OxyBand site compared with the Xeroform site at all time points during postoperative days 4 to 12. There was no difference in the cosmetic outcome of the wounds at 30 to 45 days postoperatively. This study revealed a decrease in the time to healing and in pain at donor sites dressed with an oxygen-diffusion dressing. C1 [Lairet, Kimberly F.; Baer, David; Leas, Michelle L.; Renz, Evan M.; Cancio, Leopoldo C.] US Army Inst Surg Res, Ft Sam Houston, TX 79234 USA. RP Cancio, LC (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 79234 USA. FU Clinical Trials Task Area, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD; U.S. Army Medical Materiel Agency, Fort Detrick, MD FX This study is funded by the Clinical Trials Task Area, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. Dressings were donated by OxyBand Technologies, Inc. (Woodbury, MN) and this study was conducted under a Cooperative Research and Development Agreement between the U.S. Army Institute of Surgical Research and OxyBand. OxyBand received advanced development funding from the U.S. Army Medical Materiel Agency, Fort Detrick, MD. NR 11 TC 7 Z9 7 U1 2 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2014 VL 35 IS 3 BP 214 EP 218 DI 10.1097/BCR.0b013e31829b3338 PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AG4MS UT WOS:000335394600011 PM 23877142 ER PT J AU Danielson, KT AF Danielson, Kent T. TI Simple and Effective Approach for Polar Decomposition of the Deformation Gradient Tensor SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article DE Deformation; Nonlinear analysis; Finite element method; Structural dynamics; Transient response; Decomposition; Nonlinear analysis; Finite-element method (FEM); Structural dynamics; Transient response ID PARALLEL COMPUTATION; FINITE; METHODOLOGIES; INTEGRATION; ROTATION AB A precise iterative strategy to compute the polar decomposition of the three-dimensional deformation gradient tensor is presented for nonlinear solid mechanics analysis software. By exploiting relationships between various stretch tensors, polar decomposition is transformed into the solution of six nonlinear (quadratic) simultaneous equations, via Newton-Raphson (N-R), and a subsequent 3x3 matrix inversion and multiplication. The approach is easy to program and is versatile in its applicability to statics or dynamics. With only modest computational increases, the approximations and potential numerical drift of incremental decomposition schemes is avoided. Convergence can be accelerated using stretch histories, which, coupled with a modified N-R approach, can reduce computer times. Using an explicit central difference time integration scheme, convergence is shown to be attained in only a few iterations with very tight tolerances for severe deformations. Numerical examples compare different method variations that are demonstrated to be robust and efficient. The results also demonstrate its effectiveness for large time increments (the entire analysis), which can be especially useful for static and implicit solvers. C1 US Army Engineer Res & Dev Ctr, Res Grp, Engn Syst & Mat Div, Geotech & Struct Lab,CEERD GM R, Vicksburg, MS 39180 USA. RP Danielson, KT (reprint author), US Army Engineer Res & Dev Ctr, Res Grp, Engn Syst & Mat Div, Geotech & Struct Lab,CEERD GM R, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Kent.T.Danielson@usace.army.mil FU Department of Defense (DoD) High Performance Computing Modernization Program at the U.S. Army Engineer Research and Development Center (ERDC) DoD Supercomputing Resource Center (DSRC) FX Permission to publish was granted by the Director of the Geotechnical and Structures Laboratory. The work was supported in part by a grant of computer time from the Department of Defense (DoD) High Performance Computing Modernization Program at the U.S. Army Engineer Research and Development Center (ERDC) DoD Supercomputing Resource Center (DSRC). The author thanks Professor Rebecca Brannon of the University of Utah for testing the present method on her large set of example deformation gradient tensors. NR 24 TC 0 Z9 0 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD MAY 1 PY 2014 VL 140 IS 5 DI 10.1061/(ASCE)EM.1943-7889.0000731 PG 10 WC Engineering, Mechanical SC Engineering GA AF1XZ UT WOS:000334508500018 ER PT J AU Rodrigues, EG Smith, K Maule, AL Sjodin, A Li, Z Romanoff, L Kelsey, K Proctor, S McClean, MD AF Rodrigues, Ema G. Smith, Kristen Maule, Alexis L. Sjodin, Andreas Li, Zheng Romanoff, Lovisa Kelsey, Karl Proctor, Susan McClean, Michael D. TI Urinary Polycyclic Aromatic Hydrocarbon (OH-PAH) Metabolite Concentrations and the Effect of GST Polymorphisms Among US Air Force Personnel Exposed to Jet Fuel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID GENETIC POLYMORPHISMS; INHALATION EXPOSURE; NAPHTHALENE; BIOMARKERS; 1-HYDROXYPYRENE; 2-NAPHTHOL; NAPHTHOLS; CYP1A1; CYP2E1; JP-8 AB Objective: To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms. Methods: Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites. Results: Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol ( = 0.17; P = <0.0001), 2-naphthol ( = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations ( = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1. Conclusions: USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene. C1 [Rodrigues, Ema G.; Smith, Kristen] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Maule, Alexis L.; Proctor, Susan; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA. [Sjodin, Andreas; Li, Zheng; Romanoff, Lovisa] Ctr Dis Control & Prevent, Organ Analyt Toxicol Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Kelsey, Karl] Brown Univ, Sch Med, Dept Epidemiol, Providence, RI 02912 USA. [Proctor, Susan] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan] VA Boston Healthcare Syst, Boston, MA USA. RP Rodrigues, EG (reprint author), 665 Huntington Ave,Bldg 1 Room 1404F, Boston, MA 02115 USA. EM emarod@hsph.harvard.edu RI Sjodin, Andreas/F-2464-2010; McClean, Michael/J-2934-2015 FU US Army Medical Research and Materiel Command Award [W81XWH-06-1-0105] FX This research project was funded by the US Army Medical Research and Materiel Command Award (W81XWH-06-1-0105; PI: SP Proctor) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 24 TC 4 Z9 4 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2014 VL 56 IS 5 BP 465 EP 471 DI 10.1097/JOM.0000000000000142 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH1FZ UT WOS:000335866500003 PM 24806557 ER PT J AU Dobson, NR Patel, RM Smith, PB Kuehn, DR Clark, J Vyas-Read, S Herring, A Laughon, MM Carlton, D Hunt, CE AF Dobson, Nicole R. Patel, Ravi M. Smith, P. Brian Kuehn, Devon R. Clark, Jennifer Vyas-Read, Shilpa Herring, Amy Laughon, Matthew M. Carlton, David Hunt, Carl E. TI Trends in Caffeine Use and Association between Clinical Outcomes and Timing of Therapy in Very Low Birth Weight Infants SO JOURNAL OF PEDIATRICS LA English DT Article ID EXTREMELY PRETERM INFANTS; PATENT DUCTUS-ARTERIOSUS; BLOOD-FLOW-VELOCITY; BRONCHOPULMONARY DYSPLASIA; INTENSIVE-CARE; PREMATURITY; APNEA; PREVENTION; MORTALITY; AGE AB Objective To examine the effect of early initiation of caffeine therapy on neonatal outcomes and characterize the use of caffeine therapy in very low birth weight (VLBW) infants. Study design We analyzed a cohort of 62 056 VLBW infants discharged between 1997 and 2010 who received caffeine therapy. We compared outcomes in infants receiving early caffeine therapy (initial dose before 3 days of life) and those receiving late caffeine therapy (initial dose at or after 3 days of life) through propensity scoring using baseline and early clinical variables. The primary outcome was the association between the timing of caffeine initiation and the incidence of bronchopulmonary dysplasia (BPD) or death. Results We propensity score-matched 29 070 VLBW infants at a 1: 1. Of infants receiving early caffeine therapy, 3681 (27.6%) died or developed BPD, compared with 4591 infants (34.0%) receiving late caffeine therapy (OR, 0.74; 99% CI, 0.69-0.80). Infants receiving early caffeine had a lower incidence of BPD (23.1% vs 30.7%; OR, 0.68; 95% CI, 0.63-0.73) and a higher incidence of death (4.5% vs 3.7%; OR, 1.23; 95% CI, 1.05-1.43). Infants receiving early caffeine therapy had less treatment of patent ductus arteriosus (OR, 0.60; 95% CI, 0.55-0.65) and a shorter duration of mechanical ventilation (mean difference, 6 days; P < .001). Conclusion Early caffeine initiation is associated with a decreased incidence of BPD. Randomized trials are needed to determine the efficacy and safety of early caffeine prophylaxis in VLBW infants. C1 [Dobson, Nicole R.; Hunt, Carl E.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Patel, Ravi M.; Vyas-Read, Shilpa; Carlton, David] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. [Patel, Ravi M.; Vyas-Read, Shilpa; Carlton, David] Childrens Healthcare Atlanta, Atlanta, GA USA. [Smith, P. Brian] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA. [Kuehn, Devon R.] Womack Army Med Ctr, Dept Pediat, Ft Bragg, NC USA. [Clark, Jennifer; Herring, Amy] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA. [Laughon, Matthew M.] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA. RP Smith, PB (reprint author), DCRI, Box 17969, Durham, NC 27715 USA. EM brian.smith@duke.edu RI Patel, Ravi/B-7218-2011; Smith, Phillip/I-5565-2014 OI Patel, Ravi/0000-0002-7444-5550; FU National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000454, KL2TR000455]; Eunice Kennedy Shriver National Institutes of Child Health and Human Development [HHSN267200700051C, HHSN275201000003I, 1K23HL092225-01]; American Recovery and Reinvestment Act [1R18AE000028-01]; National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) [UL1TR001117] FX Supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR000454 and KL2TR000455 to R. P.) and the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (HHSN267200700051C, HHSN275201000003I, and 1K23HL092225-01), the American Recovery and Reinvestment Act (1R18AE000028-01 to P. S.), and the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH; UL1TR001117). The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, US government, or NIH. The authors declare no conflicts of interest. NR 36 TC 24 Z9 26 U1 2 U2 12 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAY PY 2014 VL 164 IS 5 BP 992 EP + DI 10.1016/j.jpeds.2013.12.025 PG 10 WC Pediatrics SC Pediatrics GA AG6GB UT WOS:000335516000011 PM 24461786 ER PT J AU Krueger, CA Aden, J AF Krueger, Chad A. Aden, James TI Is There an Association Between Study Materials and Scores on the American Board of Orthopaedic Surgeons Part 1 Examination? SO JOURNAL OF SURGICAL EDUCATION LA English DT Article DE orthopaedic in-training examination; American Board of Orthopaedic Surgeons; study resources; orthopaedic review ID IN-TRAINING EXAMINATION; CERTIFYING EXAMINATION; PERFORMANCE; SECTION; USMLE; PREDICTORS; QUESTIONS; PATHOLOGY; SUCCESS AB BACKGROUND: Previous studies have shown that certain orthopaedic in-training examination scores can be used to identify which residents may be at risk for failing the American Board of Orthopaedic Surgeons (ABOS) Part 1 examination. However, no studies have examined how study resources may affect residents' ABOS Part 1 scores. The goal of this study is to determine which review sources or review courses, if any, are associated with improved ABOS Part 1 scores. METHODS: A survey was sent to 221 of the 865 examinees who took the ABOS Part 1 examination in 2012. The questions inquired the respondents how well they performed on previous orthopaedic in-training examinations and ABOS Part 1, along with the study sources they most commonly used, review courses they attended, and resources they would recommended if they were to retake ABOS Part 1 examination. RESULTS: Overall, 118 of the 221 (53%) survey recipients completed the survey. Six (5%) of the respondents failed ABOS Part 1 examination. Orthobullets and the American Academy of Orthopaedic Surgeons self-assessment examinations were recommended as the primary study source significantly more (p < 0.01) than most other resources, but there was no significant association between study source and passing ABOS Part 1 or scoring in a certain percentile on ABOS Part 1. Similarly, there were no associations between attending a review course and either passing or scoring in a certain percentile for ABOS Part 1. Half of the respondents who failed ABOS Part 1 attended multiple review courses. CONCLUSIONS: There does not appear to be an association between improved ABOS Part 1 scores and orthopedic study materials or review courses. Further research into the value of certain educational modalities should be conducted to determine the best ways to educate orthopedic residents and determine the value of some of these commonly used orthopedic review modalities. Published by Elsevier Inc. on behalf of the Association of Program Directors in Surgery C1 [Krueger, Chad A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Aden, James] US Army, Inst Surg Res, Dept Stat & Biostat, Ft Sam Houston, TX 78234 USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil NR 23 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 EI 1878-7452 J9 J SURG EDUC JI J. Surg. Educ. PD MAY-JUN PY 2014 VL 71 IS 3 BP 375 EP 384 DI 10.1016/j.jsurg.2013.11.005 PG 10 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA AH9MV UT WOS:000336467400015 PM 24797854 ER PT J AU Sondeen, JL Prince, MD Polykratis, IA Hernandez, O Torres-Mendoza, J De Guzman, R Aden, JK Dubick, MA AF Sondeen, Jill L. Prince, Malcolm D. Polykratis, Irene A. Hernandez, Orlando Torres-Mendoza, Jaime De Guzman, Rodolfo Aden, James K. Dubick, Michael A. TI Blood-Banking Techniques for Plateletpheresis in Swine SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID DAMAGE CONTROL RESUSCITATION; HEMORRHAGIC-SHOCK; HUMAN COAGULATION; PIG PLATELETS; DOMESTIC PIGS; PORCINE BLOOD; ANIMAL-MODELS; STORAGE; CELLS; LEUCOREDUCTION AB During the past several years, trauma resuscitation in human patients has evolved from decreased use of crystalloids to increased use of blood products. Of high interest is the role of platelets in trauma resuscitation. Because conducting prehospital resuscitation in human trauma patients is very difficult, swine are often the animal model of choice for such studies because their coagulation and hemodynamic systems are similar to those in humans. However, consistent production of sufficient swine platelets for such studies has not previously been achieved. We developed a method for producing swine platelets by using standard human techniques and equipment. We assessed pH, pO(2), pCO(2), lactate, thromboelastography, and platelet aggregation over 5 d of storage to determine whether the swine platelet product met the American Association of Blood Banks (AABB) standards for transfusion. Swine platelets met AABB standards at 24 h but not at later time points. In addition, we fluorescently labeled nonautologous platelets and then measured their percentage recovery over 5 h (the time used in subsequent experimental studies) when transfused into a recipient pig. We showed that 80% of the platelets stored for 24 h remained in the circulation and increased the recipient pigs' thromboelastographic responses, indicating that the platelets were viable and active. Therefore, swine platelets stored for 24 h by using standard human products met the AABB criteria and were functional. C1 [Sondeen, Jill L.; Prince, Malcolm D.; Polykratis, Irene A.; Hernandez, Orlando; Torres-Mendoza, Jaime; De Guzman, Rodolfo; Aden, James K.; Dubick, Michael A.] US Army, Inst Surg Res, San Antonio, TX USA. RP Sondeen, JL (reprint author), US Army, Inst Surg Res, San Antonio, TX USA. EM jill.l.sondeen.vol@mail.mil FU US Army Medical Research and Materiel Command FX This study was supported by the US Army Medical Research and Materiel Command. NR 42 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAY PY 2014 VL 53 IS 3 BP 307 EP 316 PG 10 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AH5UJ UT WOS:000336196300012 PM 24827574 ER PT J AU Zarowiecki, M Linton, YM Post, RJ Bangs, MJ Htun, PT Hlaing, T Seng, CM Baimai, V Ding, TH Sochantha, T Walton, C AF Zarowiecki, Magdalena Linton, Yvonne-Marie Post, Rory J. Bangs, Michael J. Htun, Pe Than Hlaing, Thaung Seng, Chang Moh Baimai, Visut Trung Ho Ding Sochantha, Tho Walton, Catherine TI Repeated landmass reformation limits diversification in the widespread littoral zone mosquito Anopheles sundaicus sensu lato in the Indo-Oriental Region SO MOLECULAR ECOLOGY LA English DT Article DE isolation with migration; biogeography; speciation; Anopheles epiroticus; mannose phosphate isomerase (Mpi); vicariance ID SOUTH-EAST ASIA; MITOCHONDRIAL-DNA; CELLIA SUNDAICUS; COMPARATIVE PHYLOGEOGRAPHY; ECOLOGICAL SPECIATION; DIPTERA-CULICIDAE; RAIN-FORESTS; GENE FLOW; POPULATION; COMPLEX AB Southeast Asia harbours abundant biodiversity, hypothesized to have been generated by Pliocene and Pleistocene climatic and environmental change. Vicariance between the island of Borneo, the remaining Indonesian archipelago and mainland Southeast Asia caused by elevated sea levels during interglacial periods has been proposed to lead to diversification in the littoral zone mosquito Anopheles (Cellia) sundaicus (Rodenwaldt) sensu lato. To test this biogeographical hypothesis, we inferred the population history and assessed gene flow of A.sundaicus s.l. sampled from 18 populations across its pan-Asian species range, using sequences from mitochondrial cytochrome c oxidase subunit 1 (CO1), the internal transcribed spacer 2 (ITS2) and the mannose phosphate isomerase (Mpi) gene. A hypothesis of ecological speciation for A.sundaicus involving divergent adaptation to brackish and freshwater larval habitats was also previously proposed, based on a deficiency of heterozygotes for Mpi allozyme alleles in sympatry. This hypothesis was not supported by Mpi sequence data, which exhibited no fixed differences between brackish and freshwater larval habitats. Mpi and CO1 supported the presence of up to eight genetically distinct population groupings. Counter to the hypothesis of three allopatric species, divergence was often no greater between Borneo, Sumatra/Java and the Southeast Asian mainland than it was between genetic groupings within these landmasses. An isolation-with-migration (IM) model indicates recurrent gene flow between the current major landmasses. Such gene flow would have been possible during glacial periods when the current landmasses merged, presenting opportunities for dispersal along expanding and contracting coastlines. Consequently, Pleistocene climatic variation has proved a homogenizing, rather than diversifying, force for A.sundaicus diversity. C1 [Zarowiecki, Magdalena] Wellcome Trust Sanger Inst, Parasite Genom Grp, Cambridge CB10 1SA, England. [Linton, Yvonne-Marie] Smithsonian Inst Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Post, Rory J.] Liverpool John Moores Univ, Sch Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England. [Bangs, Michael J.] Int SOS, Publ Hlth & Malaria Control, Kuala Kencana 99920, Papua, Indonesia. [Htun, Pe Than; Hlaing, Thaung] Minist Hlth, Dept Hlth, Natl Malaria Control Programme, Nay Pyi Taw, Myanmar. [Seng, Chang Moh] World Hlth Org Cambodia, Phnom Penh, Cambodia. [Baimai, Visut] Mahidol Univ, Dept Biol, Fac Sci, Bangkok 10400, Thailand. [Trung Ho Ding] Natl Inst Malariol Parasitol & Entomol, Hanoi, Vietnam. [Sochantha, Tho] Natl Ctr Malaria Control Parasitol & Entomol, Phnom Penh, Cambodia. [Walton, Catherine] Univ Manchester, Fac Life Sci, Manchester M13 9PL, Lancs, England. RP Zarowiecki, M (reprint author), Wellcome Trust Sanger Inst, Parasite Genom Grp, Wellcome Trust Genome Campus, Cambridge CB10 1SA, England. EM mz3@sanger.ac.uk OI Zarowiecki, Magdalena/0000-0001-6102-7731 FU Natural History Museum (NHM), London FX The authors wish to thank the Natural History Museum (NHM), London, for funding the PhD study of MZZ. Most of the work was carried out while MZZ, YML and RP were at NHM. We would like to thank U Sein Minh, U Thi Ha and other staff at the Department of Medical Research in Lower Myanmar for help with fieldwork and Dr. Erling Pedersen for providing specimens from Simeulue. This manuscript was prepared in part while YML held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defence. NR 75 TC 2 Z9 2 U1 2 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 EI 1365-294X J9 MOL ECOL JI Mol. Ecol. PD MAY PY 2014 VL 23 IS 10 BP 2573 EP 2589 DI 10.1111/mec.12761 PG 17 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA AH0KN UT WOS:000335808900015 PM 24750501 ER PT J AU Hsu, CW DeLacy, BG Johnson, SG Joannopoulos, JD Soljacic, M AF Hsu, Chia Wei DeLacy, Brendan G. Johnson, Steven G. Joannopoulos, John D. Soljacic, Marin TI Theoretical Criteria for Scattering Dark States in Nanostructured Particles SO NANO LETTERS LA English DT Article DE Scattering dark states; nanostructures; light scattering; coupled-resonator-induced transparency; Fano resonances; temporal coupled-mode theory ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY; TUNABLE FANO RESONANCES; COUPLED-MODE THEORY; RADIATION CONTINUUM; PLASMONIC RESONATOR; NANOPARTICLES; LIGHT; NANOSPHERES; ABSORPTION; NANOSHELL AB Nanostructures with multiple resonances can exhibit a suppressed or even completely eliminated scattering of light, called a scattering dark state. We describe this phenomenon with a general treatment of light scattering from a multiresonant nanostructure that is spherical or nonspherical but subwavelength in size. With multiple resonances in the same channel (i.e., same angular momentum and polarization), coherent interference always leads to scattering dark states in the low-absorption limit, regardless of the system details. The coupling between resonances is inevitable and can be interpreted as arising from far-field or near-field. This is a realization of coupled-resonator-induced transparency in the context of light scattering, which is related to but different from Fano resonances. Explicit examples are given to illustrate these concepts. C1 [Hsu, Chia Wei; Joannopoulos, John D.; Soljacic, Marin] MIT, Dept Phys, Cambridge, MA 02139 USA. [Hsu, Chia Wei] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. [DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA. RP Hsu, CW (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA. EM cwhsu@mit.edu RI Hsu, Chia Wei/G-5486-2011 OI Hsu, Chia Wei/0000-0002-9609-7155 FU Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001]; Materials Research Science and Engineering Centers of the National Science Foundation [DMR-0819762] FX The authors thank Owen Miller, Bo Zhen, Hongsheng Chen, and Ruixun Zhang for helpful discussions. This work was partially supported by the Army Research Office through the Institute for Soldier Nanotechnologies under Contract No. W911NF-13-D-0001 and also in part by the Materials Research Science and Engineering Centers of the National Science Foundation under Grant DMR-0819762. NR 67 TC 27 Z9 27 U1 7 U2 67 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD MAY PY 2014 VL 14 IS 5 BP 2783 EP 2788 DI 10.1021/nl500340n PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AH4CR UT WOS:000336074800086 PM 24805881 ER PT J AU Ambrosio, A Pfannenstiel, T Bach, K Cornelissen, C Gaconnet, C Brigger, MT AF Ambrosio, Art Pfannenstiel, Travis Bach, Kevin Cornelissen, Chris Gaconnet, Cory Brigger, Matthew T. TI Difficult Airway Management for Novice Physicians A Randomized Trial Comparing Direct and Video-Assisted Laryngoscopy SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE emergency airway; intubation; laryngoscope; simulator; Glidescope ID HUMAN PATIENT SIMULATOR; TRACHEAL INTUBATION; MANNEQUIN; GLIDESCOPE(R); SCOPE AB Objectives To detect a difference in (1) intubation success and (2) successful intubation times between novice physicians using a Macintosh-style or video-assisted laryngoscope on a difficult airway manikin. Study Design Prospective randomized trial. Setting Academic, tertiary medical center. Methods Forty first-year residents across a variety of disciplines with fewer than 5 total live intubations were recruited for the study. Testing took place during orientation prior to commencement of clinical duties. The entire group was provided training by faculty otolaryngologists and anesthesiologists using both laryngoscope types on a manikin airway simulator in a standard intubating scenario. Subjects were then randomized into 2 testing groups, using either a Macintosh laryngoscope or video-assisted laryngoscope in a difficult intubation scenario. The difficult airway simulation entailed oral cavity/oropharyngeal obstruction using inflation of the tongue, as well as cervical spine immobilization with a rigid collar preventing extension and elevation of the head and limiting oral cavity opening. Success was defined as a confirmed endotracheal intubation by the testing instructor in 120 seconds or less. Results The Macintosh laryngoscope group (n = 19) had an intubation success rate of 47.4% with a mean intubation time of 69.0 seconds (95% confidence interval [CI]: 52.7, 85.2). The video-assisted group (n = 21) demonstrated a significantly higher success rate of 100% (P < .0001) and a decreased mean intubation time of 23.1 seconds (95% CI: 18.4, 27.8; P < .0001). The mean difference in success rate between groups was 52.6% (95% CI: 30.0%, 75.3%). Conclusions Novice physicians with little to no prior intubation experience showed significantly higher intubation success with lower intubation times using a video-assisted laryngoscope in a difficult airway manikin simulator. C1 [Ambrosio, Art; Pfannenstiel, Travis; Bach, Kevin; Brigger, Matthew T.] Naval Med Ctr San Diego, Dept Otolaryngol Head & Neck Surg, San Diego, CA 92134 USA. [Pfannenstiel, Travis] Brooke Army Med Ctr, San Antonio, TX USA. [Cornelissen, Chris; Gaconnet, Cory] Naval Med Ctr San Diego, Dept Anesthesiol, San Diego, CA 92134 USA. RP Ambrosio, A (reprint author), Naval Med Ctr San Diego, Dept Otolaryngol Head & Neck Surg, 34800 Bob Wilson Dr,Suite 200, San Diego, CA 92134 USA. EM ambrosio@ucla.edu NR 9 TC 4 Z9 5 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAY PY 2014 VL 150 IS 5 BP 775 EP 778 DI 10.1177/0194599814521380 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA AG7BF UT WOS:000335572300011 PM 24477825 ER PT J AU Scalzitti, N Brennan, J Bothwell, N Brigger, M Ramsey, M Gallagher, T Maturo, S AF Scalzitti, Nicholas Brennan, Joseph Bothwell, Nici Brigger, Matthew Ramsey, Mitchell Gallagher, Thomas Maturo, Stephen TI Military Otolaryngology Resident Case Numbers and Board Passing Rates during the Afghanistan and Iraq Wars SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE surgical case numbers; board examination; residency ID OPERATION-ENDURING-FREEDOM; COMBAT INJURIES; WOUNDS; DEATH; TEAM AB Objective During the wars in Iraq and Afghanistan, the US military has continued to train medical residents despite concern that postgraduate medical education at military training facilities has suffered. This study compares the experience of otolaryngology residents at military programs with the experience of their civilian counterparts. Study Design Retrospective review. Setting Academic military medical centers. Subjects and Methods Resident caseload data and board examination passing rates were requested from each of the 6 Department of Defense otolaryngology residency programs for 2001 to 2010. The American Board of Otolaryngology and the Accreditation Council for Graduate Medical Education provided the national averages for resident caseload. National board passing rates from 2004 to 2010 were also obtained. Two-sample t tests were used to compare the pooled caseloads from the military programs with the national averages. Board passing rates were compared with a test of proportions. Results Data were available for all but one military program. Regarding total cases, only 2001 and 2003 showed a significant difference (P < .05), with military residents completing more cases in those years. For individual case categories, the military averages were higher in Otology (299.6 vs 261.2, P = .033) and Plastics/Reconstruction (248.1 vs 149.2, P = .003). Only the Head & Neck category significantly favored the national average over the military (278.3 and 226.0, P = .039). The first-time board passing rates were identical between the groups (93%). Conclusion Our results suggest that the military otolaryngology residency programs are equal in terms of caseload and board passing rates compared with civilian programs over this time period. C1 [Scalzitti, Nicholas; Brennan, Joseph; Maturo, Stephen] San Antonio Mil Med Ctr, San Antonio, TX 78251 USA. [Bothwell, Nici] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Brigger, Matthew] Naval Med Ctr San Diego, San Diego, CA USA. [Ramsey, Mitchell] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Gallagher, Thomas] Naval Med Ctr Portsmouth, Portsmouth, VA USA. RP Scalzitti, N (reprint author), San Antonio Mil Med Ctr, 2338 Jarve Valley, San Antonio, TX 78251 USA. EM Nicholas.j.scalzitti.mil@mail.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAY PY 2014 VL 150 IS 5 BP 787 EP 791 DI 10.1177/0194599814522401 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA AG7BF UT WOS:000335572300014 PM 24549121 ER PT J AU Salzer Salzer, W Burke, M Devidas, M Gore, L Larsen, E Zaoutis, T Fisher, B Steinbach, W Hilden, J Loh, M Winick, N Carroll, W Raetz, E Sung, LL Hunger, S AF Salzer Salzer, Wanda Burke, Mike Devidas, Meenakshi Gore, Lia Larsen, Eric Zaoutis, Theoklis Fisher, Brian Steinbach, William Hilden, Joanne Loh, Mignon Winick, Naomi Carroll, William Raetz, Elizabeth Sung, Lillian Hunger, Stephen TI INDUCTION MORTALITY AND ITS ASSOCIATION WITH INVASIVE FUNGAL INFECTIONS (IFI) IN CHILDREN AND YOUNG ADULTS WITH HIGH RISK (HR) B-LYMPHOBLASTIC LEUKEMIA (B-ALL): EARLY RESULTS FROM CHILDREN'S ONCOLOGY GROUP STUDY AALL1131 SO PEDIATRIC BLOOD & CANCER LA English DT Meeting Abstract C1 [Salzer; Salzer, Wanda; Burke, Mike; Devidas, Meenakshi; Gore, Lia; Larsen, Eric; Zaoutis, Theoklis; Fisher, Brian; Steinbach, William; Hilden, Joanne; Loh, Mignon; Winick, Naomi; Carroll, William; Raetz, Elizabeth; Sung, Lillian; Hunger, Stephen] US Army Med Res & Mat Command, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1545-5009 EI 1545-5017 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD MAY PY 2014 VL 61 SU 1 SI SI BP S5 EP S5 PG 1 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA AG5WT UT WOS:000335490100016 ER PT J AU Gaines, DN Operario, DJ Stroup, S Stromdahl, E Wright, C Gaff, H Broyhill, J Smith, J Norris, DE Henning, T Lucas, A Houpt, E AF Gaines, David N. Operario, Darwin J. Stroup, Suzanne Stromdahl, Ellen Wright, Chelsea Gaff, Holly Broyhill, James Smith, Joshua Norris, Douglas E. Henning, Tyler Lucas, Agape Houpt, Eric TI Ehrlichia and Spotted Fever Group Rickettsiae Surveillance in Amblyomma americanum in Virginia Through Use of a Novel Six-Plex Real-Time PCR Assay SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Ticks; Vector borne; Rickettsia; Real-time RT-PCR; Ehrlichia ID WHITE-TAILED DEER; GULF-COAST TICKS; UNITED-STATES; DERMACENTOR-VARIABILIS; EXPERIMENTAL-INFECTION; SOUTHEASTERN VIRGINIA; PANOLA MOUNTAIN; NORTH-CAROLINA; PARKERI; PREVALENCE AB The population of the lone star tick Amblyomma americanum has expanded in North America over the last several decades. It is known to be an aggressive and nondiscriminatory biter and is by far the most common human-biting tick encountered in Virginia. Few studies of human pathogen prevalence in ticks have been conducted in our state since the mid-twentieth century. We developed a six-plex real-time PCR assay to detect three Ehrlichia species (E. chaffeensis, E. ewingii, and Panola Mountain Ehrlichia) and three spotted fever group Rickettsiae (SFGR; R. amblyommii, R. parkeri, and R. rickettsii) and used it to test A. americanum from around the state. Our studies revealed a presence of all three Ehrlichia species (0-24.5%) and a high prevalence (50-80%) of R. amblyommii, a presumptively nonpathogenic SFGR, in all regions surveyed. R. parkeri, previously only detected in Virginia's Amblyomma maculatum ticks, was found in A. americanum in several surveyed areas within two regions having established A. maculatum populations. R. rickettsii was not found in any sample tested. Our study provides the first state-wide screening of A. americanum ticks in recent history and indicates that human exposure to R. amblyommii and to Ehrlichiae may be common. The high prevalence of R. amblyommii, serological cross-reactivity of all SFGR members, and the apparent rarity of R. rickettsii in human biting ticks across the eastern United States suggest that clinical cases of tick-borne disease, including ehrlichiosis, may be commonly misdiagnosed as Rocky Mountain spotted fever, and that suspicion of other SFGR as well as Ehrlichia should be increased. These data may be of relevance to other regions where A. americanum is prevalent. C1 [Gaines, David N.; Broyhill, James] Virginia Dept Hlth, Richmond, VA 23219 USA. [Operario, Darwin J.; Stroup, Suzanne; Houpt, Eric] Univ Virginia Hlth Syst, Div Infect Dis & Int Hlth, Charlottesville, VA USA. [Stromdahl, Ellen] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Wright, Chelsea; Gaff, Holly] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA. [Gaff, Holly] Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Durban, South Africa. [Smith, Joshua] Fairfax Cty Hlth Dept, Fairfax, VA USA. [Norris, Douglas E.; Henning, Tyler] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Lucas, Agape] N Carolina Agr & Tech State Univ, Greensboro, NC 27411 USA. RP Gaines, DN (reprint author), Virginia Dept Hlth, Div Environm Epidemiol, 109 Governor St,POB 2448, Richmond, VA 23219 USA. EM David.Gaines@vdh.virginia.gov FU National Institute Of Allergy and Infectious Diseases (NIAID) [K25AI067791]; Henry M. Jackson Foundation; Fairfax County, Virginia; NIH [T32 AI 007471]; Johns Hopkins Malaria Research Institute; A. Ralph and Silvia E. Barr Fellowship FX The project described was supported by grant number K25AI067791 to H. G. from the National Institute Of Allergy and Infectious Diseases (NIAID). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIAID or the National Institutes of Health (NIH). This work was also supported by the Henry M. Jackson Foundation to C. W. Support to D.E.N. for this project comes from Fairfax County, Virginia, and support to T. H. comes from NIH grant number T32 AI 007471, the Johns Hopkins Malaria Research Institute, and the A. Ralph and Silvia E. Barr Fellowship. NR 32 TC 14 Z9 14 U1 1 U2 17 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAY 1 PY 2014 VL 14 IS 5 BP 307 EP 316 DI 10.1089/vbz.2013.1509 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AG9SJ UT WOS:000335759600001 PM 24746145 ER PT J AU Guda, T Labella, C Chan, R Hale, R AF Guda, Teja Labella, Carl Chan, Rodney Hale, Robert TI Quality of bone healing: Perspectives and assessment techniques SO WOUND REPAIR AND REGENERATION LA English DT Review ID MICRO-COMPUTED TOMOGRAPHY; IN-VIVO MEASUREMENT; SCANNING ACOUSTIC MICROSCOPY; DUAL-PHOTON-ABSORPTIOMETRY; X-RAY ABSORPTIOMETRY; HIGH-RESOLUTION MRI; OF-THE-ART; MECHANICAL-PROPERTIES; TIBIAL FRACTURES; MINERAL DENSITY AB Bone regeneration and healing is an area of extensive research providing an ever-expanding set of not only therapeutic solutions for surgeons but also diagnostic tools. Multiple factors such as an ideal graft, the appropriate biochemical and mechanical wound environment, and viable cell populations are essential components in promoting healing. While bony tissue performs many functions, critical is mechanical strength, followed closely by structure. Many tools are available to evaluate bone quality in terms of quantity, structure, and strength; the purpose of this article is to identify the factors that can be evaluated and the advantages and disadvantages of each in assessing the quality of bone healing in both preclinical research and clinical settings. C1 [Guda, Teja; Labella, Carl; Chan, Rodney; Hale, Robert] US Army Inst Surg Res, Dent Trauma Res Detachment, Ft Sam Houston, TX USA. [Guda, Teja] Univ Texas San Antonio, San Antonio, TX 78249 USA. [Guda, Teja] Wake Forest Inst Regenerat Med, Winston Salem, NC USA. RP Guda, T (reprint author), Univ Texas San Antonio, AET 1-364,1 UTSA Circle, San Antonio, TX 78249 USA. EM teja.guda@utsa.edu NR 128 TC 0 Z9 0 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAY PY 2014 VL 22 SU 1 SI SI BP 39 EP 49 DI 10.1111/wrr.12167 PG 11 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA AG9SU UT WOS:000335760800008 PM 24813363 ER PT J AU Vasudevan, R Kennedy, AJ Merritt, M Crocker, FH Baney, RH AF Vasudevan, Ravikumar Kennedy, Alan J. Merritt, Megan Crocker, Fiona H. Baney, Ronald H. TI Microscale patterned surfaces reduce bacterial fouling-microscopic and theoretical analysis SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE Bioinspired; Biofilm; Topography; Antifouling; Catheter; Nosocomial infection ID ENGINEERED ANTIFOULING MICROTOPOGRAPHIES; ENTEROBACTER-CLOACAE; SOLID-SURFACES; ALGA ULVA; ZOOSPORES; ENERGY; ENTEROMORPHA; WETTABILITY; BIOADHESION; INFECTIONS AB Microscale patterned surfaces have been shown to control the arrangement of bacteria attached to surfaces. This study was conducted to examine the effect of patterned topographies on bacterial fouling using Enterobacter cloacae as the test model. E. cloacae is an opportunistic pathogen involved frequently in nosocomial infections. It is an important model organism to be studied in the context of healthcare associated infections (HAI) and polydimethylsiloxane (PDMS) based urinary catheter fouling. Patterned surfaces, such as SharkletTM, have shown the promise of being a benign surface treatment for prevention of catheter associated urinary tract infections (CAUTI). To the best of our knowledge, inhibition of fouling by E. cloacae has not been demonstrated on microscale patterned PDMS surfaces. In this study, the SharkletTM and smooth PDMS surfaces were used as controls. All pattern surfaces had statistically significantly lower percentage area coverage compared to the smooth PDMS control. A cross type feature (C-1-PDMS), demonstrated the most significant reduction in percent area coverage, 89% (p < 0.01, alpha= 0.05), compared to the smooth PDMS control and all other patterned test surfaces. Additionally, theoretical calculations show that C-1-PDMS is the only surface predicted to hold the thermodynamically stable Cassie state, which occurs due to trapping air pockets at the liquid solid interface. Combined the results provide new insights for designing environmentally benign, novel, microscale patterned surfaces for restricting bacterial fouling. (C) 2014 Elsevier B.V. All rights reserved. C1 [Vasudevan, Ravikumar; Baney, Ronald H.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Merritt, Megan] Badger Tech Serv, Vicksburg, MS USA. [Kennedy, Alan J.; Crocker, Fiona H.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Vasudevan, R (reprint author), Univ Florida, 549 Gale Lemerand Dr,Room 100 Rhines Hall, Gainesville, FL 32611 USA. EM ravikumarvk@gmail.com FU US Army Engineer Research and Development Center (ERDC) [W912HZ-08-C-0018] FX The study was conducted using funding provided under the Environmental Quality Technology Basic Research Program of the US Army Engineer Research and Development Center (ERDC W912HZ-08-C-0018; Drs. John Cullinane, Elizabeth Ferguson, Technical Directors). We acknowledge the laboratory assistance of Nick Melby and Margaret Richmond. Permission was granted by the Chief of Engineers to publish this information. NR 39 TC 16 Z9 17 U1 8 U2 50 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7765 EI 1873-4367 J9 COLLOID SURFACE B JI Colloid Surf. B-Biointerfaces PD MAY 1 PY 2014 VL 117 BP 225 EP 232 DI 10.1016/j.colsurfb.2014.02.037 PG 8 WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials SC Biophysics; Chemistry; Materials Science GA AH3JE UT WOS:000336018700030 PM 24657607 ER PT J AU Jiang, RZ Moton, E McClure, JP Bowers, Z AF Jiang, Rongzhong Moton, Elizabeth McClure, Joshua P. Bowers, Zachary TI A Highly Active and Alcohol-Tolerant Cathode Electrocatalyst Containing Ag Nanoparticles Supported on Graphene SO ELECTROCHIMICA ACTA LA English DT Article DE Graphene nano platelets; Silver nanoparticles; ORR; Alkaline fuel cell; Alcohol tolerant catalysts ID OXYGEN REDUCTION REACTION; ELECTROLYTE FUEL-CELLS; CARBON ELECTRODES; ALKALINE-SOLUTION; SILVER; PERFORMANCE; METHANOL; ELECTROREDUCTION; IMPURITIES; NANOSHEETS AB A highly active oxygen reduction reaction (ORR) catalyst was synthesized by supporting Ag nano-particles on graphene nano platelets (Ag/GNP) via ultrasound treatment. The Ag/GNP catalyzes the O-2 molecule through a 4-electron reduction to water in 0.1 M KOH electrolyte. The half-wave potential for the ORR on Ag/GNP is similar to a Pt black coated electrode (i.e -0.27V at Ag/GNP, and -0.18V at 40% Pt/C vs.SCE). The kinetic rate for the ORR on Ag/GNP is 3.16 x 10(-2) cm.s(-1) at -0.4V vs. SCE. The effect of alcohols and other impurities on the ORR catalytic activity for Ag/GNP was examined and found to be highly tolerant to methanol, ethanol and ethylene glycol. The Ag/GNP catalyst is also tolerant to tetraalkyl ammonium hydroxides; i.e. functional groups related to the chemical structure of common alkaline electrolyte membranes. Published by Elsevier Ltd. C1 [Jiang, Rongzhong; McClure, Joshua P.] US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Moton, Elizabeth; Bowers, Zachary] US Mil Acad, Dept Chem Engn, West Point, NY 10996 USA. RP Jiang, RZ (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Rongzhong.jiang.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command FX The authors would like to thank the U.S. Department of the Army and U.S. Army Materiel Command for support to this work NR 20 TC 10 Z9 10 U1 3 U2 67 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAY 1 PY 2014 VL 127 BP 146 EP 152 DI 10.1016/j.electacta.2014.01.134 PG 7 WC Electrochemistry SC Electrochemistry GA AH3FU UT WOS:000336009900019 ER PT J AU Schoenbaum, M Kessler, RC Gilman, SE Colpe, LJ Heeringa, SG Stein, MB Ursano, RJ Cox, KL AF Schoenbaum, Michael Kessler, Ronald C. Gilman, Stephen E. Colpe, Lisa J. Heeringa, Steven G. Stein, Murray B. Ursano, Robert J. Cox, Kenneth L. CA Army STARRS Collaborators TI Predictors of Suicide and Accident Death in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) Results From the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) SO JAMA PSYCHIATRY LA English DT Article ID US MILITARY; PSYCHOPATHOLOGY; ATTRITION; PERSONNEL; SOLDIERS AB IMPORTANCE The Army Study to Assess Risk and Resilience in Servicemembers ( Army STARRS) is a multicomponent study designed to generate actionable recommendations to reduce Army suicides and increase knowledge of risk and resilience factors for suicidality. OBJECTIVES To present data on prevalence, trends, and basic sociodemographic and Army experience correlates of suicides and accident deaths among active duty Regular Army soldiers between January 1, 2004, and December 31, 2009, and thereby establish a foundation for future Army STARRS investigations. DESIGN, SETTING, AND PARTICIPANTS Analysis of trends and predictors of suicide and accident deaths using Army and Department of Defense administrative data systems. Participants were all members of the US Regular Army serving at any time between 2004 and 2009. MAIN OUTCOMES AND MEASURES Death by suicide or accident during active Army service. RESULTS The suicide rate rose between 2004 and 2009 among never deployed and currently and previously deployed Regular Army soldiers. The accident death rate fell sharply among currently deployed soldiers, remained constant among the previously deployed, and trended upward among the never deployed. Increased suicide risk was associated with being a man (or a woman during deployment), white race/ethnicity, junior enlisted rank, recent demotion, and current or previous deployment. Sociodemographic and Army experience predictors were generally similar for suicides and accident deaths. Time trends in these predictors and in the Army's increased use of accession waivers (which relaxed some qualifications for new soldiers) do not explain the rise in Army suicides. CONCLUSIONS AND RELEVANCE Predictors of Army suicides were largely similar to those reported elsewhere for civilians, although some predictors distinct to Army service emerged that deserve more in-depth analysis. The existence of a time trend in suicide risk among never-deployed soldiers argues indirectly against the view that exposure to combat-related trauma is the exclusive cause of the increase in Army suicides. C1 [Schoenbaum, Michael; Colpe, Lisa J.] NIMH, Bethesda, MD 20892 USA. [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Heeringa, Steven G.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Stein, Murray B.] Univ Calif San Diego, Dept Psychiat & Family, La Jolla, CA 92093 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Prevent Med, La Jolla, CA 92093 USA. [Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA. [Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Sch Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD USA. [Cox, Kenneth L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Schoenbaum, M (reprint author), NIMH, 6001 Execut Blvd,Room 6226,Mail Stop Code 9669, Bethesda, MD 20892 USA. EM schoenbaumm@mail.nih.gov RI Gilman, Stephen/E-7632-2010 OI Gilman, Stephen/0000-0002-8331-6419 FU Department of the Army; National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Service [UO1MHO87981] FX The Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement UO1MHO87981 with the National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services. NR 18 TC 62 Z9 62 U1 1 U2 18 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAY PY 2014 VL 71 IS 5 BP 493 EP 503 DI 10.1001/jamapsychiatry.2013.4417 PG 11 WC Psychiatry SC Psychiatry GA AH2JP UT WOS:000335947600006 PM 24590048 ER PT J AU Galvin, JW Dannenbaum, JH Grassbaugh, JA Eichinger, JK AF Galvin, Joseph W. Dannenbaum, Joseph H. Grassbaugh, Jason A. Eichinger, Josef K. TI Your diagnosis? Pseudarthrosis of the Clavicle SO ORTHOPEDICS LA English DT Editorial Material ID CONGENITAL PSEUDARTHROSIS C1 [Galvin, Joseph W.; Dannenbaum, Joseph H.; Grassbaugh, Jason A.; Eichinger, Josef K.] US Army, Orthopaed Surg Serv, Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Galvin, JW (reprint author), US Army, Orthopaed Surg Serv, Madigan Army Med Ctr, Tacoma, WA 98431 USA. EM joseph.w.galvin.mil@mail.mil NR 20 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD MAY PY 2014 VL 37 IS 5 BP 295 EP + DI 10.3928/01477447-20140430-01 PG 3 WC Orthopedics SC Orthopedics GA AH2KV UT WOS:000335951000018 PM 24810809 ER PT J AU Miklaszewski, EJ Shaw, AP Poret, JC Son, SF Groven, LJ AF Miklaszewski, Eric J. Shaw, Anthony P. Poret, Jay C. Son, Steven F. Groven, Lori J. TI Performance and Aging of Mn/MnO2 as an Environmentally Friendly Energetic Time Delay Composition SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Pyrotechnic; Environmentally benign; Microchannel combustion; Pyrotechnic time delays; Manganese; Manganese dioxide; Aging ID MANGANESE-DIOXIDE; THERMAL-DECOMPOSITION; PROPAGATION AB The Mn/MnO2 reactive system was investigated as a suitable replacement for the traditional W/BaCrO4/KClO4/diatomaceous earth delay composition. The delay performance, ignition sensitivity, and aging characteristics were examined in aluminum microchannels similar in diameter to common delay housings (4.7 mm). Stoichiometries with measured combustion temperatures between 1358 and 2113 K were self-sustaining with combustion velocities ranging from 2.4 to 7.3 mm s(-1). The Mn/MnO2 system produced less gas than W/BaCrO4/KCIO4/diatomaceous earth compositions allowing consideration for use in sealed delay housings. Accelerated aging at 70 degrees C and 30% relative humidity for 8 weeks resulted in no measurable loss of performance. Safety characterization showed that this composition is not sensitive to ignition by friction or electrostatic stimuli. The combustion products (as determined by X-ray diffraction) appear to be benign based on current regulations. Therefore, the Mn/MnO2 system appears to be a suitable low gas-producing, nonsensitive, less toxic delay composition with good longevity. C1 [Miklaszewski, Eric J.; Son, Steven F.; Groven, Lori J.] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. [Shaw, Anthony P.; Poret, Jay C.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Groven, Lori J.] South Dakota Sch Mines & Technol, Dept Chem & Biol Engn, Rapid City, SD 57701 USA. RP Groven, LJ (reprint author), Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. EM lori.groven@sdsmt.edu FU Purdue University by the Armament Research, Development, and Engineering Center [TSS-242012-DK] FX This work was supported at Purdue University by the Armament Research, Development, and Engineering Center under Contract #TSS-242012-DK. NR 31 TC 2 Z9 2 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD MAY PY 2014 VL 2 IS 5 BP 1312 EP 1317 DI 10.1021/sc500148k PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AG6SB UT WOS:000335547600030 ER PT J AU Moretti, JD Sabatini, JJ Shaw, AP Gilbert, R AF Moretti, Jared D. Sabatini, Jesse J. Shaw, Anthony P. Gilbert, Robert, Jr. TI Promising Properties and System Demonstration of an Environmentally Benign Yellow Smoke Formulation for Hand-Held Signals SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Pyrotechnics; Formulation; System engineering; Solvent Yellow 33; Colored smoke; Product lifecycle management ID PERCHLORATE-FREE; CIVILIAN APPLICATIONS; LIGHT ILLUMINANTS; PYROTECHNICS; MILITARY AB A novel yellow smoke formulation, based on the environmentally benign dye Solvent Yellow 33, has been validated as a replacement for the current formulation specified for the M194 yellow smoke hand-held signal. Sieve testing has revealed a fine granulation for the candidate mixture, centered at 53 mu m. In addition, compressive strain testing has shown that the mechanical (crush) strength of pellets derived from the candidate mixture was 391 kg. Both of these properties validate the viability of the candidate composition during manufacturing and deployment. Extensive static burn testing in full-sized prototype signal assembly hardware provides insight into new ignition train concepts. The full sized prototype assembly has also been demonstrated by flight tests in actual system hardware containing the rocket motor and associated propellant. C1 [Moretti, Jared D.; Sabatini, Jesse J.; Shaw, Anthony P.; Gilbert, Robert, Jr.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. RP Moretti, JD (reprint author), US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. EM jared.d.moretti.civ@mail.mil FU "Ordnance Environmental Program - Environmental Quality Technology (OEP-EQT)" program of the U.S. Army Research, Development, and Engineering Command (RDECOM) FX The authors gratefully acknowledge the "Ordnance Environmental Program - Environmental Quality Technology (OEP-EQT)" program of the U.S. Army Research, Development, and Engineering Command (RDECOM) for funding this work. Special thanks are due to Mr. Daniel Colotti (ARDEC) for taking field photographs of outdoor tests. This manuscript has been approved by the United States government for public release; distribution is unlimited. NR 19 TC 4 Z9 4 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD MAY PY 2014 VL 2 IS 5 BP 1325 EP 1330 DI 10.1021/sc500195e PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA AG6SB UT WOS:000335547600032 ER PT J AU Geraci, NS Mukbel, RM Kemp, MT Wadsworth, MN Lesho, E Stayback, GM Champion, MM Bernard, MA Abo-Shehada, M Coutinho-Abreu, TV Ramalho-Ortigao, M Hanafi, HA Fawaz, EY El-Hossary, SS Wortmann, G Hoel, DF McDowell, MA AF Geraci, Nicholas S. Mukbel, Rami M. Kemp, Michael T. Wadsworth, Mariha N. Lesho, Emil Stayback, Gwen M. Champion, Matthew M. Bernard, Megan A. Abo-Shehada, Mahmoud Coutinho-Abreu, Iliano V. Ramalho-Ortigao, Marcelo Hanafi, Hanafi A. Fawaz, Emadeldin Y. El-Hossary, Shabaan S. Wortmann, Glenn Hoel, David F. McDowell, Mary Ann TI Profiling of Human Acquired Immunity Against the Salivary Proteins of Phlebotomus papatasi Reveals Clusters of Differential Immunoreactivity SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DELAYED-TYPE HYPERSENSITIVITY; SOUTHERN JORDAN-VALLEY; CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; ANTIBODY-RESPONSE; SAND FLIES; PSYCHODIDAE; DIPTERA; VECTOR; ANTIGENS AB Phlebotomus papatasi sand flies are among the primary vectors of Leishmania major parasites from Morocco to the Indian subcontinent and from southern Europe to central and eastern Africa. Antibody-based immunity to sand fly salivary gland proteins in human populations remains a complex contextual problem that is not yet fully understood. We profiled the immunoreactivities of plasma antibodies to sand fly salivary gland sonicates (SGSs) from 229 human blood donors residing in different regions of sand fly endemicity throughout Jordan and Egypt as well as 69 US military personnel, who were differentially exposed to P. papatasi bites and L. major infections in Iraq. Compared with plasma from control region donors, antibodies were significantly immunoreactive to five salivary proteins (12, 26, 30, 38, and 44 kDa) among Jordanian and Egyptian donors, with immunoglobulin G4 being the dominant anti-SGS isotype. US personnel were significantly immunoreactive to only two salivary proteins (38 and 14 kDa). Using k-means clustering, donors were segregated into four clusters distinguished by unique immunoreactivity profiles to varying combinations of the significantly immunogenic salivary proteins. SGS-induced cellular proliferation was diminished among donors residing in sand fly-endemic regions. These data provide a clearer picture of human immune responses to sand fly vector salivary constituents. C1 [Geraci, Nicholas S.; Mukbel, Rami M.; Kemp, Michael T.; Wadsworth, Mariha N.; Stayback, Gwen M.; Champion, Matthew M.; Bernard, Megan A.; McDowell, Mary Ann] Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. [Lesho, Emil] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lesho, Emil; Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Abo-Shehada, Mahmoud] Jordan Univ Sci & Technol, Dept Vet Basic Sci, Irbid, Jordan. [Coutinho-Abreu, Iliano V.; Ramalho-Ortigao, Marcelo] Kansas State Univ, Dept Entomol, Manhattan, KS 66506 USA. [Hanafi, Hanafi A.; Fawaz, Emadeldin Y.; El-Hossary, Shabaan S.; Hoel, David F.] US Naval Med Res Unit 3 NAMRU 3, Res Sci Directorate, Cairo, Egypt. RP McDowell, MA (reprint author), Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. EM ngeraci1@nd.edu; rmmukbel@just.edu.jo; mikemp@umich.edu; mwadswor@nd.edu; emil.p.lesho.mil@mail.mil; staybac@nd.edu; Matthew.M.Champion.8@nd.edu; mbernar2@nd.edu; mshehada@e-parasite.com; iliano@ksu.edu; mortigao@ksu.edu; yahanafi@yahoo.com; emadel-din.yehia.eg@namru3.med.navy.mil; shabaan.elhossary.ctr.eg@med.navy.mil; glenn.w.wortmann@medstar.net; david.hoel@med.navy.mil; mcdowell.11@nd.edu OI Geraci, Nicholas/0000-0003-4294-9188 FU Defense Advanced Research Projects Agency [W911NF0410380]; US Defense Advanced Research Projects Agency [BAA 04-12] FX This work was supported by Defense Advanced Research Projects Agency Contract W911NF0410380 (to M.A.D.). Major funding was provided by the US Defense Advanced Research Projects Agency (BAA 04-12). NR 59 TC 5 Z9 5 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2014 VL 90 IS 5 BP 923 EP 938 DI 10.4269/ajtmh.13-0130 PG 16 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AG8ZN UT WOS:000335707600028 PM 24615125 ER PT J AU Sarkar, J Wolfe, SQ Ching, BH Kellicut, DC AF Sarkar, Joy Wolfe, Stacey Q. Ching, Brian H. Kellicut, Dwight C. TI Bow Hunter's Syndrome Causing Vertebrobasilar Insufficiency in a Young Man with Neck Muscle Hypertrophy SO ANNALS OF VASCULAR SURGERY LA English DT Article ID VERTEBRAL ARTERY-OCCLUSION; HERNIATED CERVICAL DISC; TECHNICAL CASE-REPORT; OF-THE-LITERATURE; ROTATIONAL OCCLUSION; ATLANTOAXIAL JOINT; HEAD ROTATION; FIBROUS BAND; STROKE; DECOMPRESSION AB Vertebrobasilar insufficiency is characterized by impaired blood flow within the posterior circulation, producing symptoms of vertigo, nausea, vomiting, visual disturbances, and syncope. Given these nonspecific symptoms, the diagnosis of vertebrobasilar ischemia may be difficult to distinguish from more benign conditions. A healthy 37-year-old man presented to our clinic with near syncope upon turning his head to the left. Dynamic angiography revealed occlusion of the left vertebral artery at C7 with 90 degrees head rotation to the left, consistent with bow hunter's syndrome. No obvious bony abnormalities were identified on computed tomography or magnetic resonance imaging scans. Transient rotational vertebral artery syndrome, a rare cause of vertebrobasilar insufficiency, has most often been reported at the C1-2 level, and the majority of cases occur in patients >50 years of age because of degenerative osteophytes and contralateral atherosclerosis. We present the unusual case of a young man with symptoms of vertebrobasilar insufficiency and discuss the potential effects of weightlifting and neck muscle hypertrophy on vertebral artery flow dynamics. C1 [Sarkar, Joy; Wolfe, Stacey Q.; Kellicut, Dwight C.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Ching, Brian H.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Sarkar, J (reprint author), Tripler Army Med Ctr, Dept Gen Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM joy.sarkar07@gmail.com NR 62 TC 1 Z9 1 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 EI 1615-5947 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD MAY PY 2014 VL 28 IS 4 AR 1032.e1 DI 10.1016/j.avsg.2013.06.038 PG 10 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AG8GB UT WOS:000335655700040 PM 24184499 ER PT J AU Sartori, DA Chan, DW AF Sartori, David A. Chan, Daniel W. TI Biomarkers in prostate cancer: what's new? SO CURRENT OPINION IN ONCOLOGY LA English DT Review DE aggressiveness; biomarkers; genomics; prostate cancer; proteomics ID RADICAL PROSTATECTOMY; HEALTH INDEX; ANTIGEN; MEN; MULTICENTER; PCA3; SURVEILLANCE; DIAGNOSIS; BIOPSIES; UTILITY AB Purpose of reviewThis review is intended to provide an overview of the current state of biomarkers for prostate cancer (PCa), with a focus on biomarkers approved by the US Food and Drug Administration (FDA) as well as biomarkers available from Clinical Laboratory Improvement Amendment (CLIA)-certified clinical laboratories within the last 1-2 years.Recent findingsDuring the past 2 years, two biomarkers have been approved by the US FDA. These include proPSA as part of the Prostate Health Index (phi) by Beckman Coulter, Inc and PCA3 as Progensa by Gen Probe, Inc. With the advances in genomic and proteomic technologies, several new CLIA-based laboratory-developed tests have become available. Examples are Oncotype DX from Genomics Health, Inc, and Prolaris from Myriad Genetics, Inc. In most cases, these new tests are based on a combination of multiple genomic or proteomic biomarkers.SummarySeveral new tests, as discussed in this review, have become available during the last 2 years. Although the intended use of most of these tests is to distinguish PCa from benign prostatic conditions with better sensitivity and specificity than prostate-specific antigen, studies have shown that some of them may also be useful in the differentiation of aggressive from nonaggressive forms of PCa. C1 [Sartori, David A.] Johns Hopkins Med Inst, Dept Pathol Clin Chem, Baltimore, MD 21231 USA. [Sartori, David A.] US Army Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Chan, Daniel W.] Johns Hopkins Med Inst, Dept Pathol Clin Chem Oncol Radiol & Urol, Baltimore, MD 21231 USA. RP Chan, DW (reprint author), Johns Hopkins Med Inst, CRB2,Rm 3M05,1550 Orleans St, Baltimore, MD 21231 USA. EM dchan@jhmi.edu FU National Cancer Institute EDRN program; National Cancer Institute CPTAC program FX Daniel Chan is currently receiving grants from the National Cancer Institute EDRN and CPTAC programs. For the remaining author none are declared. The authors have no conflicts of interest to disclose. NR 50 TC 42 Z9 45 U1 1 U2 25 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1040-8746 EI 1531-703X J9 CURR OPIN ONCOL JI Curr. Opin. Oncol. PD MAY PY 2014 VL 26 IS 3 BP 259 EP 264 DI 10.1097/CCO.0000000000000065 PG 6 WC Oncology SC Oncology GA AF9IP UT WOS:000335028900004 PM 24626128 ER PT J AU DeGregorio, BA Weatherhead, PJ Sperry, JH AF DeGregorio, Brett A. Weatherhead, Patrick J. Sperry, Jinelle H. TI Power lines, roads, and avian nest survival: effects on predator identity and predation intensity SO ECOLOGY AND EVOLUTION LA English DT Article DE Brown-headed cowbirds; edge effects; habitat fragmentation; nest cameras; nest predation; rat snakes ID SNAKES ELAPHE-OBSOLETA; HABITAT USE; FOREST FRAGMENTATION; SUCCESS; BIRDS; LANDSCAPE; SELECTION; THERMOREGULATION; METAANALYSIS; ENVIRONMENT AB Anthropogenic alteration of landscapes can affect avian nest success by influencing the abundance, distribution, and behavior of predators. Understanding avian nest predation risk necessitates understanding how landscapes affect predator distribution and behavior. From a sample of 463 nests of 17 songbird species, we evaluated how landscape features (distance to forest edge, unpaved roads, and power lines) influenced daily nest survival. We also used video cameras to identify nest predators at 137 nest predation events and evaluated how landscape features influenced predator identity. Finally, we determined the abundance and distribution of several of the principal predators using surveys and radiotelemetry. Distance to power lines was the best predictor of predator identity: predation by brown-headed cowbirds (Molothrus ater), corvids (Corvus sp. and Cyanocitta cristata), racers (Coluber constrictor), and coachwhips (Masticophis flagellum) increased with proximity to power lines, whereas predation by rat snakes (Elaphe obsoleta) and raptors decreased. In some cases, predator density may reliably indicate nest predation risk because racers, corvids, and cowbirds frequently used power line right-of-ways. Of five bird species with enough nests to analyze individually, daily nest survival of only indigo buntings (Passerina cyanea) decreased with proximity to power lines, despite predation by most predators at our site being positively associated with power lines. For all nesting species combined, distance to unpaved road was the model that most influenced daily nest survival. This pattern is likely a consequence of rat snakes, the locally dominant nest predator (28% of predation events), rarely using power lines and associated areas. Instead, rat snakes were frequently associated with road edges, indicating that not all edges are functionally similar. Our results suggest that interactions between predators and landscape features are likely to be specific to both the local predators and landscape. Thus, predicting how anthropogenic changes to landscapes affect nesting birds requires that we know more about how landscape changes affect the behavior of nest predators and which nest predators are locally important. C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL USA. RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM Badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. Animals were collected under South Carolina Department of Natural Resources permits #G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the University of Illinois (IACUC #11054) and University of Georgia (AUP #A2011 04-007-Y2-A0). NR 46 TC 10 Z9 10 U1 11 U2 92 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD MAY PY 2014 VL 4 IS 9 BP 1589 EP 1600 DI 10.1002/ece3.1049 PG 12 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA AG2SQ UT WOS:000335267000007 PM 24967077 ER PT J AU Moroni, M Elliott, TB Deutz, NE Olsen, CH Owens, R Christensen, C Lombardini, ED Whitnall, MH AF Moroni, Maria Elliott, Thomas B. Deutz, Nicolaas E. Olsen, Cara H. Owens, Rossitsa Christensen, Christine Lombardini, Eric D. Whitnall, Mark H. TI Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: Early hematological changes and systemic inflammatory response syndrome in minipig SO INTERNATIONAL JOURNAL OF RADIATION BIOLOGY LA English DT Article DE Animal model; minipig; ARS; radiation; SIRS; blood ID GOTTINGEN MINIPIG; CITRULLINE; EXPOSURE; DAMAGE AB Purpose: To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal (GI-ARS) syndrome. Methods: Male minipigs, approximately 5 months old, 9-12 kg in weight, were irradiated with Cobalt-60 (total body, bilateral gamma irradiation, 0.6 Gy/min). Endpoints were 10-day survival, gastrointestinal histology, plasma citrulline, bacterial translocation, vomiting, diarrhea, vital signs, systemic inflammatory response syndrome (SIRS), febrile neutropenia (FN). Results: We exposed animals to doses (2.2-5.0 Gy) above those causing H-ARS (1.6-2.0 Gy), and evaluated development of ARS. Compared to what was observed during H-ARS (historical data: Moroni et al. 2011a, 2011c), doses above 2 Gy produced signs of increasingly severe pulmonary damage, faster deterioration of clinical conditions, and faster increases in levels of C-reactive protein (CRP). In the range of 4.6-5.0 Gy, animals died by day 9-10; signs of the classic GI syndrome, as measured by diarrhea, vomiting and bacterial translocation, did not occur. At doses above 2 Gy we observed transient reduction in circulating citrulline levels, and animals exhibited earlier depletion of blood elements and faster onset of SIRS and FN. Conclusions: An accelerated hematopoietic subsyndrome (AHARS) is observed at radiation doses between those producing H-ARS and GI-ARS. It is characterized by early onset of SIRS and FN, and greater lung damage, compared to H-ARS. C1 [Moroni, Maria; Owens, Rossitsa; Whitnall, Mark H.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Radiat Countermeasures Program, Bethesda, MD 20814 USA. [Elliott, Thomas B.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Combined Injury Program, Bethesda, MD 20814 USA. [Deutz, Nicolaas E.] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA. [Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Christensen, Christine] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Div Comparat Pathol, Bethesda, MD 20814 USA. RP Moroni, M (reprint author), Armed Forces Radiobiol Res Inst, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM maria.moroni@usuhs.edu OI Deutz, Nicolaas/0000-0001-5845-6447 FU National Institute of Allergy and Infectious Diseases [OD-0505-01]; Armed Forced Radiobiology Research Institute (AFRRI) RBB2DG FX This work was supported by funding from the National Institute of Allergy and Infectious Diseases OD-0505-01 and the Armed Forced Radiobiology Research Institute (AFRRI) RBB2DG. The opinions or assertions contained herein are the private views of the authors and are not necessarily those of AFRRI, the Uniformed Services University of the Health Sciences, or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Special thanks are due to AFRRI's Cobalt facility and the Veterinary Sciences Department staff for their dedication to the project and superb animal care. NR 21 TC 6 Z9 6 U1 0 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0955-3002 EI 1362-3095 J9 INT J RADIAT BIOL JI Int. J. Radiat. Biol. PD MAY PY 2014 VL 90 IS 5 BP 363 EP 372 DI 10.3109/09553002.2014.892226 PG 10 WC Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA AG5GO UT WOS:000335447700005 PM 24524283 ER PT J AU Lurchachaiwong, W Chan, TC Richards, AL Mccardle, W Schuster, AL AF Lurchachaiwong, Woradee Chan, Teik-Chye Richards, Allen L. Mccardle, Wesley Schuster, Anthony L. TI Establishment of Orientia tsutsugamushi Lc-1 (Rickettsiales: Rickettsiaceae) Infection in ICR Outbred Mice (Rodentia: Muridae) by Needle Challenge SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE scrub typhus; Orientia tsutsugamushi; mouse model; mite; Leptotrombidium ID SCRUB TYPHUS AB Orientia tsutsugamushi is a pathogen transmitted by Leptotrombidium that causes scrub typhus. To develop an infection mouse model, a mite-derived isolate of O. tsutsugamushi was established from a laboratory-maintained colony of Leptotrombidium chiangraiensis (O. tsutsugamushi Lc-1). This Lc-1 isolate was initially presented to ICR (CD-1) mice by feeding an infected Lc chigger on the ear of a mouse. Once the Lc-1 was adapted to the ICR mice, quantitative real-time polymerase chain reaction was used to investigate O. tsutsugamushi genomic equivalent copies in tissues and sera. Furthermore, times to onset of the signs of infection are reported in this study. This study provides information useful for future research on this host pathogen interaction and the associated vaccine effieacy trials. C1 [Lurchachaiwong, Woradee; Mccardle, Wesley; Schuster, Anthony L.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. [Chan, Teik-Chye; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA. RP Lurchachaiwong, W (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. EM woradeel@afrims.org FU U.S. Army Medical and Material Command; AFRIMS Institutional Animal Care and Use Committee [08-04] FX We thank Kriangkrai Lerdthusnee, Wei-Mei Ching, and all staff at the department of Entomology, AFRIMS, Bangkok, Thailand, for assistance and kind support. Funding for this project was partially provided by the U.S. Army Medical and Material Command. All procedures involving animals were approved by the AFRIMS Institutional Animal Care and Use Committee (protocol number 08-04). NR 6 TC 2 Z9 2 U1 0 U2 2 PU ENTOMOLOGICAL SOC AMER PI ANNAPOLIS PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2014 VL 51 IS 3 BP 658 EP 660 DI 10.1603/ME13025 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AG8IB UT WOS:000335660900020 PM 24897859 ER PT J AU Wang, CJ Pan, YL Coleman, M AF Wang, Chuji Pan, Yong-Le Coleman, Mark TI Experimental observation of particle cones formed by optical trapping SO OPTICS LETTERS LA English DT Article ID PHOTOPHORETIC FORCE; RADIATION PRESSURE; MANIPULATION; AIR AB We report on observation of particle cones formed by optical trapping of absorbing particles in air using two sets of simple geometric optical schemes. Further, the trapped particles on a cone in both schemes are size-sorted with large particles or particle ensembles close to the cone vertex. This new experimental observation shows an excellent example of 3D particle trapping between the two extreme cases, photon radiation trapping of nonabsorbing particles and photophoretic trapping of strongly absorbing particles; and the observation may challenge theoretical calculations of the trapping forces applied in this case. (C) 2014 Optical Society of America C1 [Wang, Chuji; Pan, Yong-Le; Coleman, Mark] US Army, Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA. RP Pan, YL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency [HDTRA136477]; US Army Research Laboratory mission funds; US Army Research Office [W911NF-13-1-0429, W911NF-13-1-0297] FX This research was supported by the Defense Threat Reduction Agency under contract number HDTRA136477, the US Army Research Laboratory mission funds, and the US Army Research Office grants W911NF-13-1-0429 and W911NF-13-1-0297. NR 19 TC 5 Z9 5 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD MAY 1 PY 2014 VL 39 IS 9 BP 2767 EP 2770 DI 10.1364/OL.39.002767 PG 4 WC Optics SC Optics GA AG5YX UT WOS:000335496400061 PM 24784098 ER PT J AU Moore, NLT Gauchan, S Genovese, RF AF Moore, Nicole L. T. Gauchan, Sangeeta Genovese, Raymond F. TI Adolescent traumatic stress experience results in less robust conditioned fear and post-extinction fear cue responses in adult rats SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Adolescence; Development; Stress; Fear conditioning; Operant behavior; Conditioned suppression ID EARLY-LIFE STRESS; BASOLATERAL AMYGDALA; POTENTIATED STARTLE; UNDERWATER TRAUMA; POSTTRAUMATIC-STRESS; CHILDHOOD ADVERSITY; PAVLOVIAN FEAR; MEMORY; SUPPRESSION; JUVENILE AB Early exposure to a traumatic event may produce lasting effects throughout the lifespan. Traumatic stress during adolescence may deliver a distinct developmental insult compared with more-often studied neonatal or juvenile traumatic stress paradigms. The present study describes the lasting effects of adolescent traumatic stress upon adulthood fear conditioning. Adolescent rats were exposed to a traumatic stressor (underwater trauma, UWT), then underwent fear conditioning during adulthood. Fear extinction was tested over five conditioned suppression extinction sessions three weeks later. The efficacies of two potential extinction-enhancing compounds, endocannabinoid reuptake inhibitor AM404 (10 mg/kg) and M1 muscarinic positive allosteric modulator BQCA (10 mg/kg), were also assessed. Finally, post-extinction fear responses were examined using a fear cue (light) as a prepulse stimulus. Rats traumatically stressed during adolescence showed blunted conditioned suppression on day 1 of extinction training, and AM404 reversed this effect. Post-extinction startle testing showed that fear conditioning eliminates prepulse inhibition to the light cue. Startle potentiation was observed only in rats without adolescent UWT exposure. AM404 and BQCA both ameliorated this startle potentiation, while BQCA increased startle in the UWT group. These results suggest that exposure to a traumatic stressor during adolescence alters developmental outcomes related to stress response and fear extinction compared to rats without adolescent traumatic stress exposure, blunting the adulthood fear response and reducing residual post-extinction fear expression. Efficacy of pharmacological interventions may also vary as a factor of developmental traumatic stress exposure. (C) 2014 Elsevier Inc. All rights reserved. C1 [Moore, Nicole L. T.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Moore, NLT (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Nicole.LMoore46.ctr@mail.mil FU Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command FX The authors thank Christina Johnson, Christine Tobin, and Laurence Simmons for laboratory support and Daniel Altman for valuable contributions to data processing and manuscript preparation. This study was supported by the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command. N.L.T.M. is a National Research Council Postdoctoral Fellow. NR 51 TC 5 Z9 6 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD MAY PY 2014 VL 120 BP 17 EP 24 DI 10.1016/j.pbb.2014.01.011 PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA AG7QJ UT WOS:000335612600003 PM 24491436 ER PT J AU Pasiakos, SM Lieberman, HR McLellan, TM AF Pasiakos, Stefan M. Lieberman, Harris R. McLellan, Tom M. TI Effects of Protein Supplements on Muscle Damage, Soreness and Recovery of Muscle Function and Physical Performance: A Systematic Review SO SPORTS MEDICINE LA English DT Review ID CHAIN AMINO-ACID; ENDURANCE CYCLING PERFORMANCE; FORCE ECCENTRIC EXERCISE; WELL-TRAINED MEN; RESISTANCE EXERCISE; CARBOHYDRATE-PROTEIN; SKELETAL-MUSCLE; FED STATE; DIETARY SUPPLEMENTATION; MICRORNA EXPRESSION AB Background Protein supplements are frequently consumed by athletes and recreationally-active individuals, although the decision to purchase and consume protein supplements is often based on marketing claims rather than evidence-based research. Objective To provide a systematic and comprehensive analysis of literature examining the hypothesis that protein supplements enhance recovery of muscle function and physical performance by attenuating muscle damage and soreness following a previous bout of exercise. Data Source English language articles were searched with PubMed and Google Scholar using protein and supplements together with performance, exercise, competition and muscle, alone or in combination as keywords. Study Selection Inclusion criteria required studies to recruit healthy adults less than 50 years of age and to evaluate the effects of protein supplements alone or in combination with carbohydrate on performance metrics including time-to-exhaustion, time-trial or isometric or isokinetic muscle strength and markers of muscle damage and soreness. Twenty-seven articles were identified of which 18 dealt exclusively with ingestion of protein supplements to reduce muscle damage and soreness and improve recovery of muscle function following exercise, whereas the remaining 9 articles assessed muscle damage as well as performance metrics during single or repeat bouts of exercise. Study Appraisal and synthesis Methods Papers were evaluated based on experimental design and examined for confounders that explain discrepancies between studies such as dietary control, training state of participants, sample size, direct or surrogate measures of muscle damage, and sensitivity of the performance metric. Results High quality and consistent data demonstrated there is no apparent relationship between recovery of muscle function and ratings of muscle soreness and surrogate markers of muscle damage when protein supplements are consumed prior to, during or after a bout of endurance or resistance exercise. There also appears to be insufficient experimental data demonstrating ingestion of a protein supplement following a bout of exercise attenuates muscle soreness and/or lowers markers of muscle damage. However, beneficial effects such as reduced muscle soreness and markers of muscle damage become more evident when supplemental protein is consumed after daily training sessions. Furthermore, the data suggest potential ergogenic effects associated with protein supplementation are greatest if participants are in negative nitrogen and/or energy balance. Limitations Small sample numbers and lack of dietary control limited the effectiveness of several investigations. In addition, studies did not measure the effects of protein supplementation on direct indices of muscle damage such as myofibrillar disruption and various measures of protein signaling indicative of a change in rates of protein synthesis and degradation. As a result, the interpretation of the data was often limited. Conclusion Overwhelmingly, studies have consistently demonstrated the acute benefits of protein supplementation on post-exercise muscle anabolism, which, in theory, may facilitate the recovery of muscle function and performance. However, to date, when protein supplements are provided, acute changes in post-exercise protein synthesis and anabolic intracellular signaling have not resulted in measureable reductions in muscle damage and enhanced recovery of muscle function. Limitations in study designs together with the large variability in surrogate markers of muscle damage reduced the strength of the evidence-base. C1 [Pasiakos, Stefan M.; Lieberman, Harris R.] US Army, Res Inst Environm Med USARIEM, Mil Nutr Div, Natick, MA 01760 USA. [McLellan, Tom M.] TM McLellan Res Inc, Stouffville, ON L4A 8A7, Canada. RP McLellan, TM (reprint author), TM McLellan Res Inc, 25 Dorman Dr, Stouffville, ON L4A 8A7, Canada. EM DrTom.McLellan@gmail.com RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU US Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplements Research; Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and USAMRMC FX This work was supported by the US Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplements Research. The views, opinions and/or findings in this report are those of the authors, and should not be construed as an official Department of the Army position, policy or decision, unless so designated by other official documentation. Citation of commercial organization and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations.; T. M. McLellan was supported by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and USAMRMC. NR 83 TC 18 Z9 19 U1 7 U2 89 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 0112-1642 EI 1179-2035 J9 SPORTS MED JI Sports Med. PD MAY PY 2014 VL 44 IS 5 BP 655 EP 670 DI 10.1007/s40279-013-0137-7 PG 16 WC Sport Sciences SC Sport Sciences GA AG6YT UT WOS:000335565700007 PM 24435468 ER PT J AU Katz, J Daniel, T Goodman, A Denney, T Deshpande, G Traynham, S Iverson, G Dretsch, M AF Katz, Jeffery Daniel, Thomas Goodman, Alex Denney, Thomas Deshpande, Gopikrishna Traynham, Stephanie Iverson, Grant Dretsch, Michael TI fMRI correlates of emotional dysregulation in US soldiers with post-concussion syndrome SO BRAIN INJURY LA English DT Meeting Abstract C1 [Katz, Jeffery; Daniel, Thomas; Goodman, Alex; Denney, Thomas; Deshpande, Gopikrishna] Auburn Univ, MRI Res Ctr, Auburn, AL 36849 USA. [Traynham, Stephanie] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Iverson, Grant] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA. [Iverson, Grant] Red Sox Fdn, Boston, MA USA. [Iverson, Grant] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA. [Dretsch, Michael] HDQA, Arlington, VA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 EI 1362-301X J9 BRAIN INJURY JI Brain Inj. PD MAY PY 2014 VL 28 IS 5-6 MA 0403 BP 661 EP 662 PG 2 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AF9EA UT WOS:000335017000355 ER PT J AU Weightman, M McCulloch, K Davidson, LF Scherer, M Smith, L Finkelstein, M Radomski, MV AF Weightman, Margaret McCulloch, Karen Davidson, Leslie Freeman Scherer, Matthew Smith, Laurel Finkelstein, Marsha Radomski, Mary Vining TI Preliminary inter-rater reliability for a novel dual-task and multitask assessment battery guiding return-to-duty in concussed service members SO BRAIN INJURY LA English DT Meeting Abstract C1 [Weightman, Margaret; Finkelstein, Marsha; Radomski, Mary Vining] Allina Hlth, Courage Kenny Res Ctr, Minneapolis, MN USA. [McCulloch, Karen] Univ N Carolina, Sch Med, Div Phys Therapy, Dept Allied Hlth Sci, Chapel Hill, NC USA. [Davidson, Leslie Freeman] Shenandoah Univ, Winchester, VA USA. [Scherer, Matthew] Andrew Rader US Army Hlth Clin, Ft Myers, VA USA. [Smith, Laurel] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 EI 1362-301X J9 BRAIN INJURY JI Brain Inj. PD MAY PY 2014 VL 28 IS 5-6 MA 0627 BP 749 EP 750 PG 2 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AF9EA UT WOS:000335017000563 ER PT J AU Pugh, MJ Orman, J Jaramillo, C Salinsky, M McNamee, S Eapen, B Towne, A Grafman, J AF Pugh, Mary Jo Orman, Jean Jaramillo, Carlos Salinsky, Martin McNamee, Shane Eapen, Blessen Towne, Alan Grafman, Jordan TI The prevalence of epilepsy and association with traumatic brain injury in veterans of the Afghanistan and Iraq wars SO BRAIN INJURY LA English DT Meeting Abstract C1 [Pugh, Mary Jo; Jaramillo, Carlos; Eapen, Blessen] South Texas Vet Healthcare Syst, San Antonio, TX USA. [Orman, Jean] US Army, Inst Surg Res, San Antonio, TX USA. [Salinsky, Martin] Portland VA Med Ctr, Portland, OR USA. [McNamee, Shane; Towne, Alan] Hunter Holmes McGuire VA Med Ctr, Richmond, VA USA. [Grafman, Jordan] Rehabil Inst Chicago, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 EI 1362-301X J9 BRAIN INJURY JI Brain Inj. PD MAY PY 2014 VL 28 IS 5-6 MA 0781 BP 807 EP 807 PG 1 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AF9EA UT WOS:000335017000706 ER PT J AU Moore, C Tovar, E Christiansen, M AF Moore, Christina Tovar, Eric Christiansen, Mollie TI Our Own Worst Enemy: Examining Interruptions During Medication Administration SO CLINICAL NURSE SPECIALIST LA English DT Meeting Abstract C1 [Moore, Christina; Christiansen, Mollie] US Army, San Antonio, TX USA. [Tovar, Eric] US Air Force, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-6274 EI 1538-9782 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD MAY-JUN PY 2014 VL 28 IS 3 BP 179 EP 179 PG 1 WC Nursing SC Nursing GA AF7XW UT WOS:000334929800028 ER PT J AU Weile, DS Hopkins, DA Gazonas, GA Powers, BM AF Weile, Daniel S. Hopkins, David A. Gazonas, George A. Powers, Brian M. TI On the proper formulation of Maxwellian electrodynamics for continuum mechanics SO CONTINUUM MECHANICS AND THERMODYNAMICS LA English DT Article DE Convective coordinates; Continuum mechanics; Electrodynamics; Relativity theory AB Despite the importance of electromagnetomechanical physics to processes ranging from piezoelectricity to the dynamics of electron beams, confusion abounds in the continuum mechanics literature as to how Maxwell's equations of electrodynamics should be formulated in the material frame of continuum mechanics. Current formulations in the literature conflict as to the manner in which the authors define fields, derive constitutive relations, and interpret contradictory formulations. The difficulties persist even when the phenomena described are electrostatic. This paper will demonstrate that the perplexity arises from two sources: a misunderstanding of the limitations of material frame descriptions, and the failure to appreciate the centrality of relativity theory to the formulation of electrodynamic equations in the vicinity of mechanical motion. Two new formulations of Maxwell's equations are provided that avoid the paradoxes of earlier formulations and thus describe the physics clearly and without self-contradiction. C1 [Weile, Daniel S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Hopkins, David A.; Gazonas, George A.; Powers, Brian M.] RDRL WMM B Army Res Lab, APG, Aberdeen, MD 21005 USA. RP Weile, DS (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. EM weile@udel.edu; david.a.hopkins.civ@mail.mil; george.a.gazonas.civ@mail.mil; brian.m.powers.civ@mail.mil OI Gazonas, George/0000-0002-2715-016X FU ORISE [1120-1120-99] FX Portions of this work was sponsored by ORISE under contract 1120-1120-99. NR 19 TC 2 Z9 2 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0935-1175 EI 1432-0959 J9 CONTINUUM MECH THERM JI Continuum Mech. Thermodyn. PD MAY PY 2014 VL 26 IS 3 BP 387 EP 401 DI 10.1007/s00161-013-0308-7 PG 15 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA AG0ZJ UT WOS:000335144200009 ER PT J AU Mahmoud, H Riveros, G AF Mahmoud, Hussam Riveros, Guillermo TI Fatigue reliability of a single stiffened ship hull panel SO ENGINEERING STRUCTURES LA English DT Article DE Fatigue; Cracks; Finite element; Stress intensity factor; Monte Carlo simulations; Residual stresses; Inspection; Probability of failure; Reliability ID CRACKS AB Fatigue cracks in ship structures are considered a nuisance as they require periodic inspection and repair. If left unrepaired, the crack could grow to reach a critical length and threaten the integrity of the structure. Although the cracks are typically characterized by stable propagation rate, the scatter in fatigue performance is difficult to quantify and could be on the order of thousands or even millions of cycles. The development of maintenance and management programs for ship structures should therefore account for the inherent scatter in performance through probabilistic fatigue assessment. Probabilistic assessment by testing a large number of specimens can be very costly. Therefore, the assessment can be performed through conducting large number of numerical or analytical simulations that account for the inherent statistical scatter in both load and resistance. This paper presents a framework for probabilistic assessment of the propagation rate of cracks in welded stiffened panels using finite element Monte Carlo simulations. The parameters influencing the propagation rate are treated as random variables with predefined statistical distributions. The results can be used for proposing inspection intervals for ships. In addition, very useful insight can be drawn on the most sensitive parameters affecting crack growth in the panels and the probability of failure at a given inspection period. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Mahmoud, Hussam] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. [Riveros, Guillermo] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Mahmoud, H (reprint author), Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. EM hussam.mahmoud@colostate.edu NR 26 TC 1 Z9 1 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 EI 1873-7323 J9 ENG STRUCT JI Eng. Struct. PD MAY 1 PY 2014 VL 66 BP 89 EP 99 DI 10.1016/j.engstruct.2014.02.007 PG 11 WC Engineering, Civil SC Engineering GA AG5AW UT WOS:000335432500009 ER PT J AU Oh, SR Sun, J Dobbs, H King, J AF Oh, So-Ryeok Sun, Jing Dobbs, Herbert King, Joel TI Model Predictive Control for Power and Thermal Management of an Integrated Solid Oxide Fuel Cell and Turbocharger System SO IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY LA English DT Article DE Model predictive control; power and thermal management; SOFC/GT hybrid system ID TURBINE HYBRID SYSTEM; CONTROL DESIGN; PERFORMANCE; OPERATION; ENGINES AB This paper identifies and addresses the control challenges associated with simultaneous power and thermal management of a 5-kW-class solid oxide fuel cell and gas turbine combined cycle system. A model predictive controller (MPC) is developed to achieve improved system performance subject to input and state constraints. The subsystem dynamic couplings and control authority limitations under thermal constraints are investigated by both static and dynamic analysis. Through judicious allocation of penalty parameters in the cost function associated with the fuel cell current, anode fuel flow rate, and generator load, several different MPC implementations are derived to explore different control design degree of freedom and their performance is evaluated. Simulation results show the efficacy of the MPC design by demonstrating the fast load transition while maintaining the stack temperature within the allowable operation limits. C1 [Oh, So-Ryeok; Sun, Jing] Univ Michigan, Dept Naval Architecture & Marine Engn, Ann Arbor, MI 48109 USA. [Dobbs, Herbert; King, Joel] US Army TARDEC, Warren, MI 48397 USA. RP Oh, SR (reprint author), Univ Michigan, Dept Naval Architecture & Marine Engn, Ann Arbor, MI 48109 USA. EM srohum@umich.edu; jingsun@umich.edu; herbert.dobbs@us.army.mil; joel.d.king@us.army.mil FU U.S. Army TARDEC through Automotive Research Center; U.S. Navy through Naval Engineering Education Center FX This work was supported in part by the U.S. Army TARDEC through Automotive Research Center and U.S. Navy through Naval Engineering Education Center, both led by the University of Michigan. Recommended by Associate Editor F. A. Cuzzola. NR 29 TC 6 Z9 6 U1 3 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6536 EI 1558-0865 J9 IEEE T CONTR SYST T JI IEEE Trans. Control Syst. Technol. PD MAY PY 2014 VL 22 IS 3 BP 911 EP 920 DI 10.1109/TCST.2013.2271902 PG 10 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA AG2BP UT WOS:000335220600008 ER PT J AU Gregory, M Kaminski, RW Lugo-Roman, LA Carrillo, HG Tilley, DH Baldeviano, C Simons, MP Reynolds, ND Ranallo, RT Suvarnapunya, AE Venkatesan, MM Oaks, EV AF Gregory, Michael Kaminski, Robert W. Lugo-Roman, Luis A. Galvez Carrillo, Hugo Hamilton Tilley, Drake Baldeviano, Christian Simons, Mark P. Reynolds, Nathanael D. Ranallo, Ryan T. Suvarnapunya, Akamol E. Venkatesan, Malabi M. Oaks, Edwin V. TI Development of an Aotus nancymaae Model for Shigella Vaccine Immunogenicity and Efficacy Studies SO INFECTION AND IMMUNITY LA English DT Article ID 2A SOMATIC ANTIGEN; FLEXNERI 2A; RHESUS-MONKEYS; COLONIC LESIONS; ANIMAL-MODEL; CAMPYLOBACTER-JEJUNI; BACILLARY DYSENTERY; DIARRHEAL DISEASE; SUBUNIT VACCINE; INVASIN COMPLEX AB Several animal models exist to evaluate the immunogenicity and protective efficacy of candidate Shigella vaccines. The two most widely used nonprimate models for vaccine development include a murine pulmonary challenge model and a guinea pig keratoconjunctivitis model. Nonhuman primate models exhibit clinical features and gross and microscopic colonic lesions that mimic those induced in human shigellosis. Challenge models for enterotoxigenic Escherichia coli (ETEC) and Campylobacter spp. have been successfully developed with Aotus nancymaae, and the addition of a Shigella-Aotus challenge model would facilitate the testing of combination vaccines. A series of experiments were designed to identify the dose of Shigella flexneri 2a strain 2457T that induces an attack rate of 75% in the Aotus monkey. After primary challenge, the dose required to induce an attack rate of 75% was calculated to be 1 Chi 10(11) CFU. Shigella-specific immune responses were low after primary challenge and subsequently boosted upon rechallenge. However, preexisting immunity derived from the primary challenge was insufficient to protect against the homologous Shigella serotype. A successive study in A. nancymaae evaluated the ability of multiple oral immunizations with live-attenuated Shigella vaccine strain SC602 to protect against challenge. After three oral immunizations, animals were challenged with S. flexneri 2a 2457T. A 70% attack rate was demonstrated in control animals, whereas animals immunized with vaccine strain SC602 were protected from challenge (efficacy of 80%; P = 0.05). The overall study results indicate that the Shigella-Aotus nancymaae challenge model may be a valuable tool for evaluating vaccine efficacy and investigating immune correlates of protection. C1 [Gregory, Michael; Lugo-Roman, Luis A.; Hamilton Tilley, Drake; Baldeviano, Christian; Simons, Mark P.; Reynolds, Nathanael D.] US Naval Med Res Unit 6 NAMRU 6, Callao, Peru. [Kaminski, Robert W.; Ranallo, Ryan T.; Suvarnapunya, Akamol E.; Venkatesan, Malabi M.; Oaks, Edwin V.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Galvez Carrillo, Hugo] Univ Nacl Mayor San Marcos, Lima 14, Peru. RP Kaminski, RW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM Robert.W.Kaminski.civ@mail.mil FU Military Infectious Disease Research Program (MIDRP) FX This work was funded by the Military Infectious Disease Research Program (MIDRP). NR 35 TC 2 Z9 2 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 2014 VL 82 IS 5 BP 2027 EP 2036 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AF4FF UT WOS:000334666200029 PM 24595138 ER PT J AU Horoho, PD AF Horoho, Patricia D. TI Maintaining, Restoring, and Improving the Health of Our Nation SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 US Army, Med Command, Ft Gordon, GA 30905 USA. RP Horoho, PD (reprint author), US Army, Med Command, Ft Gordon, GA 30905 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 2014 VL 44 IS 5 BP 318 EP 319 DI 10.2519/jospt.2014.0108 PG 2 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AG3AT UT WOS:000335288900001 PM 24787325 ER PT J AU Mcgowen, JM Su, J Koppenhaver, SL AF Mcgowen, Jared M. Su, Jonathan Koppenhaver, Shane L. TI Fracture of the Radial Head SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Mcgowen, Jared M.] Evans Army Community Hosp, Ft Carson, CO 80913 USA. [Su, Jonathan] 25th Infantry Div, Stryker Brigade Combat Team 2, Schofield Barracks, HI USA. [Koppenhaver, Shane L.] US Army Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA. RP Mcgowen, JM (reprint author), Evans Army Community Hosp, Ft Carson, CO 80913 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 2014 VL 44 IS 5 BP 377 EP 377 DI 10.2519/jospt.2014.0406 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AG3AT UT WOS:000335288900009 PM 24787327 ER PT J AU Teyhen, DS Aldag, M Centola, D Edinborough, E Ghannadian, JD Naught, A Jackson, T Kinn, J Kunkler, KJ Levine, B Martindale, VE Neal, D Snyder, LB Styn, MA Thorndike, F Trabosh, V Parramore, DJ AF Teyhen, Deydre S. Aldag, Matt Centola, Damon Edinborough, Elton Ghannadian, Jason D. Naught, Andrea Jackson, Theresa Kinn, Julie Kunkler, Kevin J. Levine, Betty Martindale, Valerie E. Neal, David Snyder, Leslie B. Styn, Mindi A. Thorndike, Frances Trabosh, Valerie Parramore, David J. TI Key Enablers to Facilitate Healthy Behavior Change: Workshop Summary SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article ID SELF-DETERMINATION THEORY; MASS-MEDIA CAMPAIGNS; INCREASE PHYSICAL-ACTIVITY; WEIGHT-LOSS MAINTENANCE; LARGE SOCIAL NETWORK; INTRINSIC MOTIVATION; COMMUNICATION CAMPAIGNS; FINANCIAL INCENTIVES; COLLECTIVE DYNAMICS; SMOKING-CESSATION AB SYNOPSIS: The increases in preventable chronic diseases and the rising costs of health care are unsustainable. The US Army Surgeon General's vision to transition from a health care system to a system of health requires the identification of key health enablers to facilitate the adoption of healthy behaviors. In support of this vision, the US Army Telemedicine add Advanced Technology Research Center hosted a workshop in April 2013 titled "Intentives to Create and Sustain Change for Health." Members of government and academia participated to identify key. health enablers that could ultimately be leveraged by technology. The key health enablers discussed included (1) public health messaging, (2) changing health habits and the environmental influence on health, (3) goal setting and tracking, (4) the role of incentives in behavior-change intervention, and (5) the role of peer and social networks on change. This. report summarizes leading evidence and the group consensus on evidence-based practices with respect to the key enablers in creating healthy behavior change. C1 [Teyhen, Deydre S.; Edinborough, Elton; Ghannadian, Jason D.; Levine, Betty] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Fort Detrick, MD USA. [Aldag, Matt; Martindale, Valerie E.] Booz Allen Hamilton, Rockville, MD USA. [Centola, Damon] Univ Penn, Annenberg Sch Commun, Social Innovat Lab, Philadelphia, PA 19104 USA. [Centola, Damon] Univ Penn, Annenberg Sch Commun, Warren Ctr Network & Data Sci, Philadelphia, PA 19104 USA. [Naught, Andrea] US Army Med Res & Mat Command, Joint Program Committee 1, Ft Detrick, MD USA. [Jackson, Theresa] Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Kinn, Julie] Joint Base Lewis McChord, Natl Ctr Telehealth & Technol, Mobile Hlth Program, Tacoma, WA USA. [Kunkler, Kevin J.] US Army Med Res & Mat Command, Joint Program Comm, Ft Detrick, MD USA. [Neal, David] Empir Res, Miami, FL USA. [Snyder, Leslie B.] Univ Connecticut, Ctr Hlth Intervent & Prevent, Storrs, CT USA. [Styn, Mindi A.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Hlth & Community Syst, Sch Nursing, Pittsburgh, PA USA. [Styn, Mindi A.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Thorndike, Frances] Univ Virginia Hlth Syst, Charlottesville, VA USA. [Trabosh, Valerie] US Army Med Res & Mat Command Military Operat M, Ft Detrick, MD USA. [Parramore, David J.] Off Surgeon Gen, Falls Church, VA USA. RP Teyhen, DS (reprint author), 1054 Patchel St, Fort Detrick, MD 21702 USA. EM deydre.s.teyhen.mil@mail.mil NR 141 TC 2 Z9 2 U1 3 U2 24 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 2014 VL 44 IS 5 BP 378 EP 387 DI 10.2519/jospt.2014.0301 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AG3AT UT WOS:000335288900010 PM 24787328 ER PT J AU Teyhen, DS Shaffer, SW Lorenson, CL Greenberg, MD Rogers, SM Koreerat, CM Villena, SL Zosel, KL Walker, MJ Childs, JC AF Teyhen, Deydre S. Shaffer, Scott W. Lorenson, Chelsea L. Greenberg, Moshe D. Rogers, Shay M. Koreerat, Christina M. Villena, Sarah L. Zosel, Kristen L. Walker, Michael J. Childs, John C. TI Clinical Measures Associated With Dynamic Balance and Functional Movement SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE Y-Balance Test; functional movement screen; injury prevention ID PATELLOFEMORAL PAIN SYNDROME; PLANTAR PRESSURE PARAMETERS; LOWER-EXTREMITY KINEMATICS; CHRONIC ANKLE INSTABILITY; INJURY RISK-FACTORS; POSTURAL CONTROL; INTRARATER RELIABILITY; INTERRATER RELIABILITY; NONOPERATIVE TREATMENT; ENDURANCE TIMES AB Teyhen, DS, Shaffer, SW, Lorenson, CL, Greenberg, MD, Rogers, SM, Koreerat, CM, Villena, SL, Zosel, KL, Walker, MJ, and Childs, JC. Clinical measures associated with dynamic balance and functional movement. J Strength Cond Res 28(5): 1272-1283, 2014-Decreased balance and impaired functional movement have been linked with increased injury risk. The purpose of our study was to determine the association between specific measures of power, strength, flexibility, balance, and endurance compared with more global measures of dynamic balance, using the Y-Balance Test (YBT), and functional movement, using the functional movement screen (FMS), in healthy soldiers. Our participants (n = 64; 53 men, 11 women) were healthy active duty service members (25.2 +/- 3.8 years, 25.1 +/- 3.1 kg center dot m(-2)). Seventeen tests with 38 associated measures of strength, power, flexibility, endurance, balance, and functional measures were assessed. A significant Pearson product moment correlation (r > 0.2 and p < 0.01) was used to narrow the number of variables of interest. Two hierarchical stepwise regression analyses were performed to determine the most parsimonious set of variables associated with the YBT and FMS performance scores. Our results included a 4 variable model (F = 13.4, p < 0.001) that was associated with YBT scores (R = 0.72, R-2 = 0.51). Superior performance on the YBT was associated with better performance on the FMS lunge and upper trunk mobility tests, decreased number of hops during a 6-m hop test, and greater gastrocnemius flexibility. A second 4 variable model (F = 11.813, p < 0.001) was associated with FMS scores (R = 0.70, R-2 = 0.50). Superior performance on the FMS was associated with greater anterior reach on the YBT, greater distance on the crossover hop test, increased hamstring flexibility, and higher levels of self-reported function through the lower-extremity functional scale. Physical fitness leaders and clinicians could use these models to inform decision making when developing and assessing the outcomes of a personalized intervention program for those with low FMS and YBT scores. C1 [Teyhen, Deydre S.; Shaffer, Scott W.; Lorenson, Chelsea L.; Greenberg, Moshe D.; Rogers, Shay M.; Koreerat, Christina M.; Villena, Sarah L.; Zosel, Kristen L.; Walker, Michael J.; Childs, John C.] US Army Baylor Univ, Doctoral Program Phys Therapy, Houston, TX 78234 USA. [Teyhen, Deydre S.] US Army Publ Hlth Command Reg South, Houston, TX USA. [Childs, John C.] 81st Med Grp, Dept Phys Therapy, Biloxi, MS USA. RP Teyhen, DS (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, Houston, TX 78234 USA. EM deydre.s.teyhen.mil@mail.mil NR 73 TC 9 Z9 9 U1 7 U2 42 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAY PY 2014 VL 28 IS 5 BP 1272 EP 1283 DI 10.1519/JSC.0000000000000272 PG 12 WC Sport Sciences SC Sport Sciences GA AG0QL UT WOS:000335119900013 PM 24755867 ER PT J AU Mann, JB Ivey, PJ Brechue, WF Mayhew, JL AF Mann, J. Bryan Ivey, Pat J. Brechue, William F. Mayhew, Jerry L. TI Reliability and Smallest Worthwhile Difference of the NFL-225 Test in NCAA Division I Football Players SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE absolute muscular endurance; bench press; muscular strength ID BENCH PRESS PERFORMANCE; MUSCULAR STRENGTH; LEAGUE COMBINE; PREDICTION; ENDURANCE; VALIDATION AB Mann, JB, Ivey, PJ, Brechue, WF, and Mayhew, JL. Reliability and smallest worthwhile difference of the NFL-225 test in NCAA Division I football players. J Strength Cond Res 28(5): 1427-1432, 2014-The NFL-225 test is widely used to assess the strength level and evaluate the progress of college football players during resistance training. Despite the studies evaluating the validity of this test, there are no reports assessing its reliability. The purpose of this study was to determine the reliability and smallest worthwhile difference (SWD) of the NFL-225 test in Division I college football players. Seventy-two players were assessed for more than 3 weeks for the number of repetitions completed with a constant load of 102.3 kg (225 lbs) during winter conditioning. Test sessions occurred on the same day and at the same time 1 week apart. Intraclass correlation coefficients (ICCs) between weeks 1 and 2 (ICC = 0.987), weeks 2 and 3 (ICC = 0.981), and across weeks 1, 2, and 3 (ICC = 0.988) indicated high relative reliability. A small technical error (TE) (TE = 0.5 repetitions) provided strong absolute reliability. The SWD suggests that a change in performance of 3 repetitions or more after training would indicate a meaningful improvement in performance for this test. C1 [Mann, J. Bryan; Ivey, Pat J.] Univ Missouri, Dept Athlet Performance, Columbia, MO USA. [Mann, J. Bryan] Univ Missouri, Dept Phys Therapy, Columbia, MO USA. [Brechue, William F.] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Mayhew, Jerry L.] Truman State Univ, Human Performance Lab, Kirksville, MO 63501 USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA. RP Mayhew, JL (reprint author), Truman State Univ, Human Performance Lab, Kirksville, MO 63501 USA. EM jmayhew@truman.edu NR 28 TC 2 Z9 2 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAY PY 2014 VL 28 IS 5 BP 1427 EP 1432 DI 10.1519/JSC.0000000000000411 PG 6 WC Sport Sciences SC Sport Sciences GA AG0QL UT WOS:000335119900032 PM 24531440 ER PT J AU Michael, NL Robb, ML AF Michael, Nelson L. Robb, Merlin L. TI Phambili: moving forward without the blindfold SO LANCET INFECTIOUS DISEASES LA English DT Editorial Material ID HIV-1 VACCINE; EFFICACY; TRIAL; STEP C1 [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Robb, Merlin L.] Henry Jackson Fdn, HIV Program, US Mil HIV Res Program, Bethesda, MD USA. RP Michael, NL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM nmichael@hivresearch.org NR 5 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAY PY 2014 VL 14 IS 5 BP 361 EP 362 DI 10.1016/S1473-3099(14)70029-5 PG 2 WC Infectious Diseases SC Infectious Diseases GA AG0GF UT WOS:000335093200003 PM 24560542 ER PT J AU Henning, PC Margolis, LM McClung, JP Young, AJ Pasiakos, SM AF Henning, Paul C. Margolis, Lee M. McClung, James P. Young, Andrew J. Pasiakos, Stefan M. TI High protein diets do not attenuate decrements in testosterone and IGF-I during energy deficit SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Weight loss; Anabolic hormones; Androgen ID GROWTH-FACTOR-I; RESISTANCE EXERCISE; SKELETAL-MUSCLE; PHYSICAL-ACTIVITY; BODY-COMPOSITION; BALANCE; MEN; RESPONSES; RESTRICTION; HORMONE AB Objective. Energy deficit (ED) diminishes fat-free mass (FFM) with concomitant reductions in anabolic hormone secretion. A modest increase in protein to recommended dietary allowance (RDA) levels during ED minimally attenuates decrements in insulin-like growth factor-I (IGF-I). The impact of dietary protein above the RDA on circulating anabolic hormones and their relationships with FFM in response to ED are not well described. Materials/Methods. Thirty-three adults were assigned diets providing protein at 0.8 (RDA), 1.6 (2x-RDA), and 2.4 (3x-RDA) g/kg/d for 31 days. Testosterone, sex-hormone binding globulin (SHBG) and IGF-I system components were assessed after a 10-day period of weight-maintenance (VIM) and after a 21-day period of ED (40%) achieved by an increase in energy expenditure and decreased energy intake. Associations between the change in FFM and anabolic hormone levels were determined. Results. As compared to WM and regardless of dietary protein intake, total and free testosterone, total IGF-I, and acid-labile subunit decreased (P < 0.05), whereas SHBG and IGF binding proteins-1, -2, and -3 increased (P < 0.05) during ED. There were no energy-by-protein interactions on any hormones or IGF-I system components measured. Changes in FFM in response to ED were negatively associated with acid-labile subunit (ALS) (r = -0.62, P < 0.05) in 2x-RDA; however, no other relationships were observed. Conclusion. Consuming a high protein diet does not impact the androgenic and IGF-I system response to ED. These data suggest that the protective effects of high protein diets on FFM during ED are likely not influenced by anabolic hormone concentrations. Published by Elsevier Inc. C1 [Henning, Paul C.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. RP Pasiakos, SM (reprint author), 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014; Biguzzi, Felipe/E-4724-2015; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU U.S. Army Medical Research and Material Command; U.S. Department of Agriculture, Agricultural Research Service FX The study was supported by the U.S. Army Medical Research and Material Command and the U.S. Department of Agriculture, Agricultural Research Service. NR 26 TC 4 Z9 4 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD MAY PY 2014 VL 63 IS 5 BP 628 EP 632 DI 10.1016/j.metabol.2014.02.007 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AG1UC UT WOS:000335200700004 PM 24641883 ER PT J AU Villamaria, CY Fries, CA Spencer, JR Roth, M Davis, MR AF Villamaria, Carole Y. Fries, C. Anton Spencer, Jerry R. Roth, Mark Davis, Michael R. TI Hydrogen Sulfide Mitigates Reperfusion Injury in a Porcine Model of Vascularized Composite Autotransplantation SO ANNALS OF PLASTIC SURGERY LA English DT Article DE microsurgery; vascularized composite tissue autotransplantation; hydrogen sulfide; ischemia and reperfusion injury; porcine; vascularized composite allotransplantation; microvascular; gracilis myocutaneous flap ID ISCHEMIA/REPERFUSION INJURY; TRANSPLANTATION; ISCHEMIA; ALLOGRAFT; FLAP; MICE; H2S AB Background Devastating extremity injuries are prevalent but often survivable on the modern battlefield. These complex injuries require advanced methods of reconstruction, involving prolonged ischemic periods and reperfusion injury. Using our group's validated porcine model of gracilis myocutaneous flap transplantation, this study demonstrates that an interim perfusion of hydrogen sulfide (H2S) mitigates the effects of reperfusion injury in the setting of delayed restoration of blood flow. Methods A gracilis myocutaneous flap (200-400 g; surface area, 250 cm(2)) was procured from the hind limb of a Yorkshire swine (70-90 kg, n = 16). The right external carotid artery and the internal jugular vein are the recipient axis. Group 1 (control, n = 6) underwent delayed anastomosis with a 3-hour ischemic period. Group 2 (n = 10) underwent a similar delayed anastomosis with an interim perfusion of H2S during the ischemic period. The animals survived for 14 days. Systemic biomarker assays for skeletal muscle tissue injury (creatine kinase, lactate dehydrogenase, and aspartate transaminase) and proinflammatory markers (tumor necrosis factor alpha and interleukin 6) provide assessment of reperfusion injury at the cellular level. Results The control animals (3 hours of ischemia with an interim perfusion of heparinized saline) demonstrated increased levels of injury biomarkers and proinflammatory cytokines compared with the animals receiving H2S infusion and identical ischemic interval. The control flaps had a mean creatine kinase level of 280 x 10(3) U/L (+/- 80 x 10(3)), compared with the H2S group, which had a mean of 99 x 10(3) U/L (+/- 14 x 10(3); P = 0.0007 at postoperative day 2). lactate dehydrogenase levels (mean) were 26 x 10(3) U/L (+/- 8 x 10(3)) versus 9 x 10(3) U/L (+/- 3 x 10(3); P = 0.0004) and aspartate transaminase levels (mean) were 1651 U/L (+/- 324) versus (873 U/L [+/- 279]; P = 0.0013) for the control and treatment groups, respectively. Similarly, an intergroup difference in IL-6 was found, although not statistically significant. Tumor necrosis factor alpha levels (mean) were 93 pg/mL (+/- 14) versus 39 pg/mL (+/- 4; P = 0.0013) for the control and treatment groups, respectively. Conclusions This study demonstrated the mitigating properties of H2S on reperfusion injury. Interim perfusion with H2S resulted in diminution of ischemia-dependent biomarkers after 3 hours of ischemia. Follow-up studies will translate these findings as an evolving method for reconstructing previously unreconstructable injuries. C1 [Villamaria, Carole Y.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Villamaria, Carole Y.; Spencer, Jerry R.; Davis, Michael R.] Joint Base San Antonio, Sci & Technol 59MDW, San Antonio, TX USA. [Fries, C. Anton] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Roth, Mark] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98104 USA. RP Fries, CA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM antonfries@gmail.com NR 20 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-7043 EI 1536-3708 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD MAY PY 2014 VL 72 IS 5 BP 594 EP 598 DI 10.1097/SAP.0000000000000021 PG 5 WC Surgery SC Surgery GA AF5YF UT WOS:000334789700020 PM 24317241 ER PT J AU Heaton, KJ Maule, AL Maruta, J Kryskow, EM Ghajar, J AF Heaton, Kristin J. Maule, Alexis L. Maruta, Jun Kryskow, Elisabeth M. Ghajar, Jamshid TI Attention and Visual Tracking Degradation During Acute Sleep Deprivation in a Military Sample SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE arousal; oculomotor; smooth pursuit; validity; sleepiness ID PURSUIT EYE-MOVEMENTS; SMOOTH-PURSUIT; PERFORMANCE; BRAIN; IMPAIRMENT; STABILITY; FATIGUE; PILOTS; SYSTEM AB Background: Fatigue due to sleep restriction places individuals at elevated risk for accidents, degraded health, and impaired physical and mental performance. Early detection of fatigue-related performance decrements is an important component of injury prevention and can help to ensure optimal performance and mission readiness. This study used a predictive visual tracking task and a computer-based measure of attention to characterize fatigue-related attention decrements in healthy Army personnel during acute sleep deprivation. Methods: Serving as subjects in this laboratory-based study were 87 male and female service members between the ages of 18 and 50 with no history of brain injury with loss of consciousness, substance abuse, or significant psychiatric or neurologic diagnoses. Subjects underwent 26 h of sleep deprivation, during which eye movement measures from a continuous circular visual tracking task and attention measures (reaction time, accuracy) from the Attention Network Test (ANT) were collected at baseline, 20 h awake, and between 24 to 26 h awake. Results: Increases in the variability of gaze positional errors (46-47%), as well as reaction time-based ANT measures (9-65%), were observed across 26 h of sleep deprivation. Accuracy of ANT responses declined across this same period (11%). Discussion: Performance measures of predictive visual tracking accurately reflect impaired attention due to acute sleep deprivation and provide a promising approach for assessing readiness in personnel serving in diverse occupational areas, including flight and ground support crews. C1 [Heaton, Kristin J.; Kryskow, Elisabeth M.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Maule, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Maruta, Jun; Ghajar, Jamshid] Brain Trauma Fdn, New York, NY USA. RP Heaton, KJ (reprint author), US Army Res Inst Environm Med, 42 Kansas St, Natick, MA 01760 USA. EM kristin.j.heaton.civ@mail.mil OI Maruta, Jun/0000-0002-5054-6605 FU Congressionally Directed Medical Research Programs (CDMRP) through an Advanced Technology Award [W81XWH-08-2-0177]; U.S. Army Medical Research and Materiel Command award [W81XWH-08-1-0021] FX This work was supported by Congressionally Directed Medical Research Programs (CDMRP) through an Advanced Technology Award (W81XWH-08-2-0177) to Jamshid Ghajar and by a U.S. Army Medical Research and Materiel Command award (W81XWH-08-1-0021; Project PI: SP Proctor, Site PI: KJ Heaton) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Jamshid Ghajar holds United States patent 7,384,399. NR 32 TC 5 Z9 6 U1 3 U2 11 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2014 VL 85 IS 5 BP 497 EP 503 DI 10.3357/ASEM.3882.2014 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AF6JO UT WOS:000334821500001 PM 24834562 ER PT J AU Stetz, TA Stetz, MC Turner, DD AF Stetz, Thomas A. Stetz, Melba C. Turner, David D. TI Mission, Physical, and War Stressors' Impact on Aircrew Psychological Strain SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE work stress; well-being; sleep; PTSD; depression; nervousness ID PHQ-9 AB Background: Little is known about the relative impact of the organization of missions on aircrew well-being. Using an occupational stress model we investigate a previously little studied concept of mission stressors and determine its relative impact in comparison to physical and war stressors in the prediction of four strains in deployed aircrews. Method: Questionnaires were completed by 272 deployed in-aircraft crewmembers. Three new stressors were developed for this study: mission stressors, physical stressors, and war stressors. In addition, four strains were measured: PTSD, depression, sleepiness, and nervousness. Regression analyses were used to examine the relative impact of each stressor on the four strain measures while controlling for age and occupation. Results: All three stressors played a significant role in the prediction strains with the total explained variance in the analyses ranging from 15% and 39%. Interestingly, mission stressors played the most important role in the prediction of strains possessing the largest partial eta squared in each analysis. The second most important stressor was physical stressors followed by war stressors. Conclusion: The importance of mission stressors may be because current training is designed to inoculate crewmembers to stressors such as the physical/environmental conditions and violentwar actions, but there is no training or acknowledgment of the importance of dealing with mission stressors. Our findings suggest it might be beneficial for commanders to address these stressors, as it may improve short-term psychological well-being, which may ultimately impact mission success and safety. C1 [Stetz, Thomas A.; Stetz, Melba C.; Turner, David D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Stetz, TA (reprint author), 97 Aikahi Loop, Kailua, HI 96734 USA. EM tstetz@hpu.edu NR 14 TC 1 Z9 1 U1 0 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2014 VL 85 IS 5 BP 568 EP 572 DI 10.3357/ASEM.3858.2014 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AF6JO UT WOS:000334821500011 PM 24834572 ER PT J AU Piekiel, NW Morris, CJ Currano, LJ Lunking, DM Isaacson, B Churaman, WA AF Piekiel, Nicholas W. Morris, Christopher J. Currano, Luke J. Lunking, David M. Isaacson, Brian Churaman, Wayne A. TI Enhancement of on-chip combustion via nanoporous silicon microchannels SO COMBUSTION AND FLAME LA English DT Article DE Porous silicon; Energetic materials; Microstructure; Acoustic initiation ID POROUS SILICON; INFRARED-SPECTROSCOPY; HYDROGEN TERMINATION; SURFACE-MORPHOLOGY; EXPLOSIVE DEVICES; HF TREATMENT; DETONATION; THERMITE; SI(111) AB Due to its high energy density and MEMS compatible fabrication methods, on-chip porous silicon shows considerable promise as an energetic material. Rapid combustion events have been demonstrated with flame propagation speeds eclipsing 3 km/s, but much is still unknown about the controlling parameters of porous silicon combustion. Recent studies show that implementation of microstructure within a nanoporous silicon film greatly increases reaction rate of a relatively slow burning system. The present work utilizes porous silicon microchannels to enhance an already rapidly-reacting system. Reactions in channeled porous silicon regions of this system propagated at speeds up to 1.2 km/s faster than similar neat porous silicon films. The fastest propagation speed was 3660 m/s, the highest reported flame speed for comparable nanoenergetic systems to date. We provide evidence that the enhancement of flame propagation rates by channeled porous silicon is mechanistically different from the convectively controlled burning of neat porous silicon. This evidence suggests the presence of acoustically aided reactions for porous silicon channel combustion where the channels more readily ignite compared to neat porous silicon. We predict this allows for propagation of the reaction by intense sound waves within the porous medium. (C) 2013 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Piekiel, Nicholas W.; Morris, Christopher J.; Lunking, David M.; Isaacson, Brian; Churaman, Wayne A.] US Army Res Lab, Adelphi, MD 20783 USA. [Currano, Luke J.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. RP Piekiel, NW (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM Nicholas.Piekiel.ctr@mail.mil FU Oak Ridge Associated Universities FX The authors would like to acknowledge funding from the Oak Ridge Associated Universities. We would also like to thank Collin Becker for helpful discussions throughout this work. NR 39 TC 8 Z9 8 U1 2 U2 34 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 EI 1556-2921 J9 COMBUST FLAME JI Combust. Flame PD MAY PY 2014 VL 161 IS 5 BP 1417 EP 1424 DI 10.1016/j.combustflame.2013.11.004 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA AF4AO UT WOS:000334654000022 ER PT J AU Ilgen, AG Majs, F Barker, AJ Douglas, TA Trainor, TP AF Ilgen, A. G. Majs, F. Barker, A. J. Douglas, T. A. Trainor, T. P. TI Oxidation and mobilization of metallic antimony in aqueous systems with simulated groundwater SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Article ID RAY-DIFFRACTION PATTERNS; QUANTITATIVE INTERPRETATION; HYDROGEN-PEROXIDE; NONTRONITE NAU-1; SHOOTING RANGES; HEAVY-METALS; HUMIC-ACID; SORPTION; SB(III); ENVIRONMENT AB Antimony (Sb) is a contaminant of concern that can be present in elevated concentrations in shooting range soils due to mobilization from spent lead/antimony bullets. Antimony in shooting range soils has been observed as either metallic Sb(0) or as Sb(V) immobilized by iron (hydr)oxides. The absence of Sb(III) in soils is indicative of rapid Sb(III) oxidation to Sb(V) under surface soil conditions. However, the major controls on antimony oxidation and mobility are poorly understood. To better understand these controls we performed multiple batch experiments under oxic conditions to quantify the oxidation and dissolution of antimony in systems where Sb(0) is oxidized to Sb(III) and further to Sb(V). We also tested how variations in the aqueous matrix composition and the presence of metallic lead (Pb) affect the dissolution, solid phase speciation, and oxidation of antimony. We monitored changes in the aqueous antimony speciation using liquid chromatography inductively coupled plasma mass spectrometry (LC-ICP-MS). To test which solid phases form as a result of Sb(0) oxidation, and therefore potentially limit the mobility of antimony in our studied systems, we characterized the partially oxidized Sb(0) powders by means of extended X-ray absorption fine structure (EXAFS) spectroscopy and powder X-ray diffraction (XRD). The observed oxidation of Sb(0) to Sb(III) and mobilization to solution is rapid: after 5-15 min of reaction the aqueous antimony concentration reached 50-600 mu M. The amount of dissolved antimony and the rate of Sb(III) oxidation to Sb(V) in deionized water is lower than what we measured in the simulated groundwater systems. Senarmontite (Sb2O3), the primary crystalline oxidation product of Sb(0), was detected after one month from the beginning of Sb(0) oxidation. The maximum aqueous Sb(III) concentration is about 30 times larger than the predicted equilibrium concentration with respect to senarmontite in the initial stages (<65 h) of our experiment. Concentrations reach equilibrium within 146-222 days. The maximum concentration of Sb(V) is controlled by cation availability for the precipitation of an antimonate. In the systems where sodium Na(I) exceeded 20 mM precipitation of mopungite is observed. No crystalline phases were detected in the systems with added lead, and the dissolved Sb(V) concentration is several orders of magnitude higher than would be expected in equilibrium with bindheimite (Pb2Sb2O7). The observed solubility of Sb(V) in the systems with Ca(II) is several orders of magnitude larger than the solubility reported for romeite (Ca2Sb2O7). The addition of Pb(0) lowered the extent of Sb(0) oxidation due to competitive oxidation or to the coupling of antimony and lead redox reactions. The results from our research can be used to identify substrates that promote precipitation of relatively insoluble antimony compounds in target berm soils and thus prevent the offsite migration of antimony from shooting range target berms. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Ilgen, A. G.; Majs, F.; Barker, A. J.; Trainor, T. P.] Univ Alaska, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Barker, A. J.; Douglas, T. A.] US Army Corps Engn, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99709 USA. RP Ilgen, AG (reprint author), Sandia Natl Labs, Dept Geochem, 1515 Eubank SE Mailstop 0754, Albuquerque, NM 87185 USA. EM agilgen@sandia.gov OI Majs, Frantisek/0000-0003-1525-7709 FU U.S. Department of Defense's Strategic Environmental Research and development Program (SERDP) [ER-1770]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences; U.S. DOE [DE-AC02-06CH11357]; National Science Foundation programs Earth Sciences [EAR-1128799]; Department of Energy, Geosciences [DE-FG02-94ER14466]; U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX Funding of this project was provided by the U.S. Department of Defense's Strategic Environmental Research and development Program (SERDP) grant ER-1770. A portion of the work was funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. We thank Matt Newville for help with XAS data acquisition at GeoSoilEnviroCARS (Sector 13), Advanced Photon Source (APS), Argonne National Laboratory. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, is supported by the U.S. DOE under Contract No. DE-AC02-06CH11357. The GeoSoilEnviroCARS is supported by the National Science Foundation programs Earth Sciences (EAR-1128799), and the Department of Energy, Geosciences (DE-FG02-94ER14466). Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. NR 59 TC 7 Z9 7 U1 8 U2 90 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 EI 1872-9533 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD MAY 1 PY 2014 VL 132 BP 16 EP 30 DI 10.1016/j.gca.2014.01.019 PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AF6NP UT WOS:000334832100002 ER PT J AU Chen, IR Bao, FY Chang, M Cho, JH AF Chen, Ing-Ray Bao, Fenye Chang, MoonJeong Cho, Jin-Hee TI Dynamic Trust Management for Delay Tolerant Networks and Its Application to Secure Routing SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE Delay tolerant networks; dynamic trust management; secure routing; performance analysis; design and validation ID ADMISSION CONTROL; ADVERSARY DETECTION; MULTIMEDIA SERVERS; ALGORITHM AB Delay tolerant networks (DTNs) are characterized by high end-to-end latency, frequent disconnection, and opportunistic communication over unreliable wireless links. In this paper, we design and validate a dynamic trust management protocol for secure routing optimization in DTN environments in the presence of well-behaved, selfish and malicious nodes. We develop a novel model-based methodology for the analysis of our trust protocol and validate it via extensive simulation. Moreover, we address dynamic trust management, i.e., determining and applying the best operational settings at runtime in response to dynamically changing network conditions to minimize trust bias and to maximize the routing application performance. We perform a comparative analysis of our proposed routing protocol against Bayesian trust-based and non-trust based (PROPHET and epidemic) routing protocols. The results demonstrate that our protocol is able to deal with selfish behaviors and is resilient against trust-related attacks. Furthermore, our trust-based routing protocol can effectively trade off message overhead and message delay for a significant gain in delivery ratio. Our trust-based routing protocol operating under identified best settings outperforms Bayesian trust-based routing and PROPHET, and approaches the ideal performance of epidemic routing in delivery ratio and message delay without incurring high message or protocol maintenance overhead. C1 [Chen, Ing-Ray; Bao, Fenye; Chang, MoonJeong] Virginia Polytech Inst & State Univ, Dept Comp Sci, Falls Church, VA 22043 USA. [Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Chen, IR (reprint author), Virginia Polytech Inst & State Univ, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA. EM irchen@vt.edu; baofenye@vt.edu; mjchang@vt.edu; jinhee.cho@us.army.mil FU Army Research Office [W911NF-12-1-0445] FX This work was supported in part by the Army Research Office under Grant W911NF-12-1-0445. NR 26 TC 36 Z9 37 U1 4 U2 14 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 EI 1558-2183 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD MAY PY 2014 VL 25 IS 5 BP 1200 EP 1210 DI 10.1109/TPDS.2013.116 PG 11 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA AF4HS UT WOS:000334673200010 ER PT J AU Hart, SD Klosky, JL Katalenich, S AF Hart, Steven D. Klosky, J. Ledlie Katalenich, Scott TI Conceptual Models for Infrastructure Leadership SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article DE Leadership; Infrastructure; Conceptual models AB In policy and aspirational documents both the American Society of Civil Engineers and the National Academy of Engineering have called for engineers of the 21st century to take a leading role in infrastructure discussions about and decisions. These discussions and decisions routinely involve stakeholders, constituencies, and organizations that are unfamiliar with traditional engineering modeling and analysis techniques; removing communication barriers is essential, but many find our engineering tools, methods, and explanations difficult to comprehend. Assuming a leadership role in these conversations requires engineers to adopt new conceptual models that enhance communication between people with dissimilar backgrounds and promote shared understanding. The West Point infrastructure models introduced in this paper provide engineers, decision makers, and members of society with a universal framework for understanding, visualizing, assessing, and describing complex infrastructure systems in a manner that facilitates communication, fosters participation in infrastructure decisions, and allows broad-based engagement with design processes. The Conceptual Model provides a basis for identifying, visualizing, and understanding the elements of an infrastructure, the functions they perform, and their relationships to each other. The Assessment Model consists of six prompts, which guide the formulation of focused assessment questions that consider the performance of systems and components, identified in the Conceptual Model, under both normal and adverse circumstances. The Resilience Model provides a framework for the design of resilient infrastructures that incorporates risk management, engineering design, emergency response, and rationally sequenced recovery. Conceptual models are essential tools for leaders seeking to effectively engage stakeholders in complex decision-making processes by building toward advancing a shared understanding; the models proposed in this paper are an effective tool in that role, and their adoption and use would facilitate deeper engagement by the public, and, ultimately, wiser societal decisions about infrastructure. C1 [Hart, Steven D.] US Army Engn Res & Dev Ctr, Vicksburg, MS 10996 USA. [Klosky, J. Ledlie; Katalenich, Scott] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Hart, SD (reprint author), US Army Engn Res & Dev Ctr, Vicksburg, MS 10996 USA. EM steven.hart@usma.edu; Ledlie.Klosky@usma.edu; scott.katalenich@usma.edu NR 14 TC 0 Z9 0 U1 2 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0742-597X EI 1943-5479 J9 J MANAGE ENG JI J. Manage. Eng. PD MAY 1 PY 2014 VL 30 IS 3 DI 10.1061/(ASCE)ME.1943-5479.0000217 PG 8 WC Engineering, Industrial; Engineering, Civil SC Engineering GA AF3IG UT WOS:000334604700010 ER PT J AU Patel, G Roncal, NE Lee, PJ Leed, SE Erath, J Rodriguez, A Sciotti, RJ Pollastri, MP AF Patel, Gautam Roncal, Norma E. Lee, Patricia J. Leed, Susan E. Erath, Jessey Rodriguez, Ana Sciotti, Richard J. Pollastri, Michael P. TI Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery SO MEDCHEMCOMM LA English DT Article ID TRYPANOSOMA-BRUCEI PHOSPHODIESTERASES; PHARMACOLOGICAL VALIDATION; TARGET; IDENTIFICATION; LEISHMANIA; COMPOUND AB Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity relationships for each parasite. In this study, we identified multiple non-toxic compounds with high potency against T. brucei and P. falciparum with good selectivity. These compounds may represent an opportunity for continued optimization. C1 [Patel, Gautam; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rodriguez, Ana] NYU, Sch Med, Dept Microbiol, Div Parasitol, New York, NY 10010 USA. [Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA. RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. EM m.pollastri@neu.edu OI Erath, Jessey/0000-0001-8802-635X; pollastri, Michael/0000-0001-9943-7197; Rodriguez, Ana/0000-0002-0060-3405 FU NIH [R01AI082577] FX We thank Professor Larry Ruben (Southern Methodist University) for helpful discussion and comments on this manuscript. This work was funded in part by NIH R01AI082577 (MPP). We appreciate a free academic license for the OpenEye suite of software. NR 15 TC 9 Z9 9 U1 0 U2 12 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-2503 EI 2040-2511 J9 MEDCHEMCOMM JI MedChemComm PD MAY PY 2014 VL 5 IS 5 BP 655 EP 658 DI 10.1039/c4md00045e PG 4 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA AF9CD UT WOS:000335011900013 PM 24910766 ER PT J AU Krall, JS Hohmann, MG Fraterrigo, JM AF Krall, Jacqueline S. Hohmann, Matthew G. Fraterrigo, Jennifer M. TI Contingent fire effects on granivore removal of exotic woody plant seeds in longleaf pine savannas SO BIOLOGICAL INVASIONS LA English DT Article DE Post-dispersal seed predation; Woody encroachment; Prescribed fire; Rodents ID ANT POGONOMYRMEX-BADIUS; SMALL MAMMALS; OLD-FIELDS; SEEDLING RECRUITMENT; SPATIAL VARIATION; TREE SEEDS; PREDATION; DISPERSAL; LANDSCAPE; ABUNDANCE AB Prescribed fire is increasingly used to inhibit woody encroachment into fire-dependent ecosystems, yet its effects on other processes influencing invasion are poorly understood. We investigated how fire influences exotic woody invasion through its effects on granivore activity, and whether these effects depend on the habitat in which seed predation takes place. We quantified seed removal for four species of exotic woody plants (Albizia julibrissin, Elaeagnus umbellata, Melia azedarach and Triadica sebifera) in 17 sites in longleaf pine savanna that varied in time since fire (one or three growing seasons post-fire) in the sandhills region of North Carolina, USA. Within each site, we established paired plots in upland and upland-wetland ecotone communities and presented seeds in depots that allowed either arthropod, or arthropod and small vertebrate access. We found that differences in seed removal with time since fire were contingent on habitat and granivore community. In ecotones, three of four species had higher proportions of seeds removed from plots that were three growing seasons post-fire than plots one growing season post-fire, whereas only T. sebifera showed this pattern in upland habitat. Allowing vertebrate granivores access to seeds enhanced seed removal, and this effect was strongest in ecotone habitat. While granivores removed seeds of all four plant species, removal of E. umbellata was significantly higher than that of the other species, suggesting that granivores exhibited seed selection. These findings suggest that ecotone habitats in this system experience greater seed removal than upland habitats, particularly as time since fire increases, and differences are mainly due to the activity of vertebrate granivores. Such differences in seed removal, together with seed selection, may contribute to variation in exotic woody invasion of longleaf pine savannas. C1 [Krall, Jacqueline S.; Fraterrigo, Jennifer M.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Hohmann, Matthew G.] US Army, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Fraterrigo, JM (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave,MC-047, Urbana, IL 61801 USA. EM jmf@illinois.edu FU Department of Defense USACE-ERDC-Construction Engineering Research Laboratory FX We thank B. Mattingly and J. Orrock for assisting with study design and T.J. Benson for help with data analysis. This research was supported by the Department of Defense USACE-ERDC-Construction Engineering Research Laboratory. J. Gray provided invaluable logistical support and assistance in the field. We also thank A. Davis and J. Dalling for providing helpful comments on early versions of the manuscript. NR 99 TC 2 Z9 2 U1 10 U2 46 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-3547 EI 1573-1464 J9 BIOL INVASIONS JI Biol. Invasions PD MAY PY 2014 VL 16 IS 5 BP 1055 EP 1068 DI 10.1007/s10530-013-0557-1 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AE7KX UT WOS:000334177900011 ER PT J AU Jordan, JB Naito, CJ Haque, BZ AF Jordan, Joseph B. Naito, Clay J. Haque, Bazle Z. (Gama) TI Progressive damage modeling of plain weave E-glass/phenolic composites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Glass fibers; Finite element analysis (FEA); Damage tolerance; Ballistic limit AB An optimized set of material properties and parameters for E-glass/phenolic composites is determined for use in the rate dependent composite damage model MAT162 in LS-DYNA. The model requires 39 material properties and parameters, and is able to capture the seven different damage modes and post damage softening behavior of composites. The unknown MAT162 parameters were determined by conducting parametric simulations of low velocity impact (LVI), depth of penetration (DOP), and ballistic impacts. The modulus reduction parameter OMGMX is found by simulating LVI tests and varying the values of OMGMX to find the best agreement with LVI experimental data. The limit of compressive volume strain for element eroding was found by simulating DOP experiments and comparing the results to the experimental data. Then the element eroding axial strain E_LIMT and EEXPN were determined by simulating ballistic impact experiments. When the optimized values were determined, analysis of ballistic experiments were conducted and compared to the experimental impact versus residual velocity curve. The results of the simulations were in excellent agreement with the experimental data. Published by Elsevier Ltd. C1 [Jordan, Joseph B.] US Army, Engineer Res & Dev Ctr, Survivabil Engn Branch, Vicksburg, MS 39180 USA. [Naito, Clay J.] Lehigh Univ, Dept Civil Engn, Bethlehem, PA 18015 USA. [Haque, Bazle Z. (Gama)] Univ Delaware, Ctr Composite Mat UD CCM, Newark, DE 19716 USA. RP Jordan, JB (reprint author), US Army, Engineer Res & Dev Ctr, Survivabil Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Joseph.B.Jordan@us.army.mil OI Naito, Clay/0000-0003-3835-8131 NR 16 TC 3 Z9 3 U1 5 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD MAY PY 2014 VL 61 BP 315 EP 323 DI 10.1016/j.compositesb.2014.01.037 PG 9 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA AE6UQ UT WOS:000334133900036 ER PT J AU Prentice, HA Ehrenberg, PK Baldwin, KM Geretz, A Andrews, C Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P O'Connell, RJ Robb, ML Kim, JH Michael, NL Thomas, R AF Prentice, Heather A. Ehrenberg, Philip K. Baldwin, Karen M. Geretz, Aviva Andrews, Charla Nitayaphan, Sorachai Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee O'Connell, Robert J. Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Thomas, Rasmi TI HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV vaccine clinical trial SO IMMUNOGENETICS LA English DT Article DE Ancestry informative markers (AIMs); Human leukocyte antigen (HLA); Killer cell immunoglobulin-like receptors (KIR); Population stratification; Thailand; RV144 ID B-VIRUS INFECTION; HETEROZYGOTE ADVANTAGE; HAPLOTYPE FREQUENCIES; RECEPTOR GENES; POPULATION; ASSOCIATION; EXPRESSION; AIDS; POLYMORPHISMS; PROGRESSION AB RV144 is the first phase 3 HIV vaccine clinical trial to demonstrate efficacy. This study consisted of more than 8,000 individuals in each arm of the trial, representing the four major regions of Thailand. Human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptor (KIR) genes, as well as 96 genome-wide ancestry informative markers (AIMs) were genotyped in 450 placebo HIV-1-uninfected individuals to identify the immunogenetic diversity and population structure of this cohort. High-resolution genotyping identified the common HLA alleles as A*02:03, A*02:07, A*11:01, A*24:02, A*24:07, A*33:03, B*13:01, B*15:02, B*18:01, B*40:01, B*44:03, B*46:01, B*58:01, C*01:02, C*03:02, C*03:04, C*07:01, C*07:02, C*07:04, and C*08:01. The most frequent three-loci haplotype was B*46:01-C*01:02-A*02:07. Framework genes KIR2DL4, 3DL2, and 3DL3 were present in all samples, and KIR2DL1, 2DL3, 3DL1, 2DS4, and 2DP1 occurred at frequencies greater than 90 %. The combined HLA and KIR profile suggests admixture with neighboring Asian populations. Principal component and correspondence analyses comparing the RV144 samples to the phase 3 International HapMap Project (HapMap3) populations using AIMs corroborated these findings. Structure analyses identified a distinct profile in the Thai population that did not match the Asian or other HapMap3 samples. This shows genetic variability unique to Thais in RV144, making it essential to take into account population stratification while performing genetic association studies. The overall analyses from all three genetic markers indicate that the RV144 samples are representative of the Thai population. This will inform subsequent host genetic analyses in the RV144 cohort and provide insight for future genetic association studies in the Thai population. C1 [Prentice, Heather A.; Ehrenberg, Philip K.; Baldwin, Karen M.; Geretz, Aviva; Andrews, Charla; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD 20910 USA. [Prentice, Heather A.; Baldwin, Karen M.; Geretz, Aviva; Andrews, Charla; Robb, Merlin L.; Thomas, Rasmi] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Nitayaphan, Sorachai; O'Connell, Robert J.] US Army Med Component, Dept Retrovirol, AFRIMS, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok, Thailand. RP Thomas, R (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD 20910 USA. EM rthomas@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense (DOD) [W81XWH-07-2-0067]; US National Institute of Allergy and Infectious Disease FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DOD). This research was funded, in part, by the US National Institute of Allergy and Infectious Disease. The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the DOD. The authors would like to acknowledge Dr. Peter Gilbert (SCHARP, Seattle) and Dr. Mark Milazzo (MHRP, Bethesda) for selecting the placebo-uninfected individuals from the RV144 study. The authors acknowledge Dr. Susan Mason from AFRIMS, Thailand for providing us with the place of origin for the RV144 samples. The authors thank Dr. Arman Bashirova from the National Cancer Institute in Frederick (NCI-Frederick) for sharing the KIR SYBR green assay and Dr. Diane Bolton from MHRP, Silver Spring for use of the Fluidigm BioMark system. The authors also thank Dr. Richard Apps (NCI-Frederick) for helpful comments. NR 41 TC 7 Z9 7 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0093-7711 EI 1432-1211 J9 IMMUNOGENETICS JI Immunogenetics PD MAY PY 2014 VL 66 IS 5 BP 299 EP 310 DI 10.1007/s00251-014-0765-6 PG 12 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA AF3FL UT WOS:000334596800002 PM 24682434 ER PT J AU Fairfax, LD Fresconi, FE AF Fairfax, Luisa D. Fresconi, Frank E. TI Position Estimation for Projectiles Using Low-Cost Sensors and Flight Dynamics SO JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE Precision projectiles; Point mass model; Flight dynamics; and control; Loosely coupled global positioning system/inertial navigation system (GPS/INS); Microelectromechanical system sensors; Guidance; State estimation; Extended Kalman filter (EKF); navigation ID NAVIGATION; GUIDANCE; SYSTEM AB Navigation of gun-launched precision munitions using affordable technologies is investigated. Estimation algorithms were developed to blend flight dynamic models with measurements from inertial sensors. The launch and flight characteristics of the unique, gun-launched environment were exploited both in the state estimator and for novel heuristic parameter identification. Using the heuristic parameter, the inertial navigation system was calibrated without a global positioning system (GPS), and its performance was compared with a similar calibration performed with a GPS. The experimental results from guided mortar flights indicate that the algorithm with only inertial sensor measurements yields position errors of less than 40 m over a 30-s flight. Trade studies were conducted in simulation to assess algorithm performance over a wider range of conditions such as variation in the flight dynamic model parameters. These results demonstrate that position errors are less than tens of meters for flight times of interest to munitions. Estimation is tolerant to inertial sensor errors because of the novel manner in which known flight dynamics are used to compensate measurements. Overall, this effort shows that navigation error resulting from a low-throughput algorithm using affordable inertial sensors is sufficient to increase system accuracy for munitions in GPS-denied environments. C1 [Fairfax, Luisa D.; Fresconi, Frank E.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Fairfax, LD (reprint author), US Army Res Lab, Weap & Mat Res Directorate, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA. EM luisa.d.fairfax.civ@mail.mil NR 33 TC 0 Z9 1 U1 3 U2 22 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0893-1321 EI 1943-5525 J9 J AEROSPACE ENG JI J. Aerosp. Eng. PD MAY 1 PY 2014 VL 27 IS 3 BP 611 EP 620 DI 10.1061/(ASCE)AS.1943-5525.0000284 PG 10 WC Engineering, Aerospace; Engineering, Civil SC Engineering GA AE9RU UT WOS:000334347400018 ER PT J AU Lu, JH Han, ZY Liu, YL Liu, WB Lee, MS Olson, MA Ruthel, G Freedman, BD Harty, RN AF Lu, Jianhong Han, Ziying Liu, Yuliang Liu, Wenbo Lee, Michael S. Olson, Mark A. Ruthel, Gordon Freedman, Bruce D. Harty, Ronald N. TI A Host-Oriented Inhibitor of Junin Argentine Hemorrhagic Fever Virus Egress SO JOURNAL OF VIROLOGY LA English DT Article ID TSG101 UEV DOMAIN; FINGER PROTEIN-Z; ARENAVIRUS INFECTIONS; ANTIVIRAL STRATEGIES; LASSA VIRUS; EBOLA; THERAPY; MOTIFS; ESCRT; VP40 AB There are currently no U. S. Food and Drug Administration (FDA)-approved vaccines or therapeutics to prevent or treat Argentine hemorrhagic fever (AHF). The causative agent of AHF is Junin virus (JUNV); a New World arenavirus classified as a National Institute of Allergy and Infectious Disease/Centers for Disease Control and Prevention category A priority pathogen. The PTAP late (L) domain motif within JUNV Z protein facilitates virion egress and transmission by recruiting host Tsg101 and other ESCRT complex proteins to promote scission of the virus particle from the plasma membrane. Here, we describe a novel compound (compound 0013) that blocks the JUNV Z-Tsg101 interaction and inhibits budding of virus-like particles (VLPs) driven by ectopic expression of the Z protein and live-attenuated JUNV Candid-1 strain in cell culture. Since inhibition of the PTAP-Tsg101 interaction inhibits JUNV egress, compound 0013 serves as a prototype therapeutic that could reduce virus dissemination and disease progression in infected individuals. Moreover, since PTAP L-domain-mediated Tsg101 recruitment is utilized by other RNA virus pathogens (e.g., Ebola virus and HIV-1), PTAP inhibitors such as compound 0013 have the potential to function as potent broad-spectrum, host-oriented antiviral drugs. C1 [Lu, Jianhong; Han, Ziying; Liu, Yuliang; Liu, Wenbo; Ruthel, Gordon; Freedman, Bruce D.; Harty, Ronald N.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. [Lee, Michael S.; Olson, Mark A.] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. [Lee, Michael S.] US Army Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD USA. RP Harty, RN (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. EM rharty@vet.upenn.edu FU National Institutes of Health/National Institute of Allergy and Infectious Diseases [AI102104, U54-AI057168] FX This study was supported in part by National Institutes of Health/National Institute of Allergy and Infectious Diseases grants AI102104 and U54-AI057168 to R.N.H. NR 48 TC 11 Z9 12 U1 2 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD MAY PY 2014 VL 88 IS 9 BP 4736 EP 4743 DI 10.1128/JVI.03757-13 PG 8 WC Virology SC Virology GA AE9TT UT WOS:000334353900012 PM 24522922 ER PT J AU McAnally, WH Wallen, CM Sanborn, SC Maak, EC AF McAnally, William H. Wallen, Christopher M. Sanborn, Steven C. Maak, Eugene C. TI Composite Risk Assessment for the Sacramento-San Joaquin Delta Levee System SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Risk; San Joaquin River; Levee; Sacramento River; Flooding; California AB The objectives of this project were to analyze available Sacramento-San Joaquin Delta, California, levee risk information in a Composite Risk Management matrix and examine the results for management decision support. U.S. Army Corps of Engineers (USACE) guidance documents define risk as the "probability and severity of loss linked to hazards" and prescribe a composite risk assessment method. The Delta Risk Management Strategy performed for a group of state and federal partners provided analyses of the relative probability of hazards and severity of risks in the Delta and provide the information needed for a risk analysis compliant with USACE requirements. Composite Risk assessment provides rank-ordered lists of the highest risk zones-those with the greatest probability of failure combined with the most severe consequences-for several hundred protected areas in the Delta. Although uncertainties in the absolute magnitude of the results make them most useful for comparisons, the actual values of the probabilities and consequences are alarming. For example, Sargent Barnhart Tract, northwest of Stockton, has a mean annual failure rate of 0.07, or an expected levee failure every 14years, with a probable 96 fatalities for a nighttime seismic-induced failure. Adjacent tracts with only slightly lower failure probabilities put another 500 lives at risk. An area of the Suisun Marsh has a projected failure rate of 0.5, or once every two years, with maximum possible damages exceeding $250million. The Sacramento Pocket Area, with a mean annual failure rate of 0.006, has over $9billion at risk. Although refinements to these risk estimates are possible, this paper and the Delta Risk Management Strategy analyses provide more than sufficient evidence that flooding in the Sacramento-San Joaquin Delta presents significant risks to California and the nation. Hundreds of lives and billions of dollar damages are at risk. Urgent action is necessary to manage those risks. C1 [McAnally, William H.] Dynam Solut LLC, Columbus, MS 39705 USA. [McAnally, William H.] Mississippi State Univ, Columbus, MS 39705 USA. [Wallen, Christopher M.; Sanborn, Steven C.] Dynam Solut LLC, Knoxville, TN 37919 USA. [Maak, Eugene C.] US Army Corps Engineers, Sacramento, CA 95814 USA. RP McAnally, WH (reprint author), Dynam Solut LLC, 486 Sagamore Cir, Columbus, MS 39705 USA. EM mcanally@gmail.com NR 16 TC 2 Z9 2 U1 3 U2 29 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PLAN MAN JI J. Water Resour. Plan. Manage.-ASCE PD MAY 1 PY 2014 VL 140 IS 5 BP 734 EP 743 DI 10.1061/(ASCE)WR.1943-5452.0000362 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AF1AF UT WOS:000334445800018 ER PT J AU Johnson, BE Dortch, MS AF Johnson, Billy E. Dortch, Mark S. TI Application of TREECS Modeling System to Strontium-90 for Borschi Watershed near Chernobyl, Ukraine SO JOURNAL OF ENVIRONMENTAL RADIOACTIVITY LA English DT Article DE TREECS; Sr-90; Chernobyl; Borschi; Radioactive modeling; Contaminant fate and transport ID RADIONUCLIDES; TRANSPORT; SOIL; STREAM; AREA; RDX AB The Training Range Environmental Evaluation and Characterization System (TREECS (TM)) (http://el.erdc.usace.army.mil/treecs/) is being developed by the U.S. Army Engineer Research and Development Center (ERDC) for the U.S. Army to forecast the fate of munitions constituents (MC) (such as high explosives (HE) and metals) found on firing/training ranges, as well as those subsequently transported to surface water and groundwater. The overall purpose of TREECS (TM) is to provide environmental specialists with tools to assess the potential for MC migration into surface water and groundwater systems and to assess range management strategies to ensure protection of human health and the environment. The multimedia fate/transport models within TREECS (TM) are mathematical models of reduced form (e.g., reduced dimensionality) that allow rapid application with less input data requirements compared with more complicated models. Although TREECS (TM) was developed for the fate of MC from military ranges, it has general applicability to many other situations requiring prediction of contaminant (including radionuclide) fate in multi-media environmental systems. TREECS (TM) was applied to the Borschi watershed near the Chernobyl Nuclear Power Plant, Ukraine. At this site. TREECS (TM) demonstrated its use as a modeling tool to predict the fate of strontium 90 (Sr-90). The most sensitive and uncertain input for this application was the soil-water partitioning distribution coefficient (Kd) for Sr-90. The TREECS (TM) soil model provided reasonable estimates of the surface water export flux of Sr-90 from the Borschi watershed when using a Kd for Sr-90 of 200 L/kg. The computed export for the year 2000 was 0.18% of the watershed inventory of Sr-90 compared to the estimated export flux of 0.14% based on field data collected during 1999-2001. The model indicated that assumptions regarding the form of the inventory, whether dissolved or in solid phase form, did not appreciably affect export rates. Also, the percentage of non-exchangeable adsorbed Sr-90, which is uncertain and affects the amount of Sr-90 available for export, was fixed at 20% based on field data measurements. A Monte Carlo uncertainty analysis was conducted treating Kd as an uncertain input variable with a range of 100-300 L/kg. This analysis resulted in a range of 0.13-0.27% of inventory exported to surface water compared to 0.14% based on measured field data. Based on this model application, it was concluded that the export of Sr-90 from the Borschi watershed to surface water is predominantly a result of soil pore water containing dissolved Sr-90 being diverted to surface waters that eventually flow out of the watershed. The percentage of non-exchangeable adsorbed Sr-90 and the soil-water K-d are the two most sensitive and uncertain factors affecting the amount of export. The 200-year projections of the model showed an exponential decline in Sr-90 export fluxes from the watershed that should drop by a factor of 10 by the year 2100. This presentation will focus on TREECS capabilities and the case study done for the Borschi Watershed. Published by Elsevier Ltd. C1 [Johnson, Billy E.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Dortch, Mark S.] Los Alamos Tech Associates LATA Inc, Vicksburg, MS USA. RP Johnson, BE (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Billy.E.Johnson@usace.army.mil; Mark.S.Dortch@usace.army.mil NR 27 TC 1 Z9 1 U1 1 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0265-931X EI 1879-1700 J9 J ENVIRON RADIOACTIV JI J. Environ. Radioact. PD MAY PY 2014 VL 131 SI SI BP 31 EP 39 DI 10.1016/j.jenvrad.2013.10.001 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE5CK UT WOS:000334005200004 PM 24220001 ER PT J AU Corona, BT Rathbone, CR AF Corona, Benjamin T. Rathbone, Christopher R. TI Accelerated functional recovery after skeletal muscle ischemiae-reperfusion injury using freshly isolated bone marrow cells SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Ischemia; Reperfusion; Stem cell; Skeletal muscle; Bone marrow; Injury ID MESENCHYMAL STEM-CELLS; ACUTE KIDNEY INJURY; ACUTE MYOCARDIAL-INFARCTION; STROMAL CELLS; ECCENTRIC CONTRACTIONS; PROGENITOR CELLS; COMPARTMENT SYNDROME; MONONUCLEAR-CELLS; STRENGTH DEFICITS; OXIDATIVE STRESS AB Background: Relatively little information exists regarding the usefulness of bone marrowe derived cells for skeletal muscle ischemia-reperfusion injury (I/R), especially when compared with I/R that occurs in other tissues. The objectives of this study were to evaluate the ability of freshly isolated bone marrow cells to home to injured skeletal muscle and to determine their effects on muscle regeneration. Materials and methods: Freshly isolated lineage-depleted bone marrow cells (Lin(-) BMCs) were injected intravenously 2 d after I/R. Bioluminescent imaging was used to evaluate cell localization for up to 28 d after injury. Muscle function, the percentage of fibers with centrally located nuclei, and the capillary-to-fiber ratio were evaluated 14 d after delivery of either saline (Saline) or saline containing Lin(-) BMCs (Lin(-) BMCs). Results: Bioluminescence was higher in the injured leg than the contralateral control leg for up to 7 d after injection (P < 0.05) suggestive of cell homing to the injured skeletal muscle. Fourteen days after injury, there was a significant improvement in maximal tetanic torque (40% versus 22% deficit; P < 0.05), a faster rate of force production (+dP/dt) (123.6 versus 94.5 Nmm/S; P < 0.05), and a reduction in the percentage of fibers containing centrally located nuclei (40 versus 17%; P < 0.05), but no change in the capillary-to-fiber ratio in the Lin(-) BMC as compared with the Saline group. Conclusions: The homing of freshly isolated BMCs to injured skeletal muscle after I/R is associated with an increase in functional outcomes. Published by Elsevier Inc. C1 [Corona, Benjamin T.; Rathbone, Christopher R.] US Army, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rathbone, CR (reprint author), US Army, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, 3698 Chambers Pass BLDG 3611, Ft Sam Houston, TX 78234 USA. EM christopher.r.rathbone.civ@mail.mil FU U.S. Army Medical Research and Materiel Command and of the Department of Defense FX This study was supported by the U.S. Army Medical Research and Materiel Command and of the Department of Defense. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or US government. The authors would like to express their sincere gratitude to Monica Jalomo, Stephanie Roth, and Alex Trevino for their invaluable technical assistance. NR 56 TC 7 Z9 9 U1 2 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD MAY PY 2014 VL 188 IS 1 BP 100 EP 109 DI 10.1016/j.jss.2013.12.026 PG 10 WC Surgery SC Surgery GA AE4RS UT WOS:000333971300014 PM 24485153 ER PT J AU Mann-Salinas, E Hayes, E Robbins, J Sabido, J Feider, L Allen, D Yoder, L AF Mann-Salinas, Elizabeth Hayes, Elizabeth Robbins, Johnnie Sabido, Jean Feider, Laura Allen, David Yoder, Linda TI A systematic review of the literature to support an evidence-based Precepting Program SO BURNS LA English DT Review DE Literature review; Nursing; Precepting; Evidence-based practice; Role transition ID KEIRSEY-TEMPERAMENT-SORTER; STAFF NURSES; PRECEPTORSHIP; QUESTIONNAIRE; STYLES; COST AB Aim: To provide a systematic review of the literature regarding development of an evidence-based Precepting Program for nurses transitioning to burn specialty practice. Background: Burned patients are admitted to specialty Burn Centers where highly complex nursing care is provided. Successful orientation and integration into such a specialized work environment is a fundamental component of a nurse's ability to provide safe and holistic patient care. Design: A systematic review of the literature was performed for the period 1995-2011 using electronic databases within PUBMED and Ovid search engines. Data sources: Databases included Medline, CINHAL, ProQuest for Dissertations and Thesis, and Cochran Collaboration using key search terms: preceptor, preceptee, preceptorship, precept*, nurs*, critical care, personality types, competency-based education, and learning styles. Review methods: Nurses graded the level and quality of evidence of the included articles using a modified 7-level rating system and the Johns Hopkins Nursing Quality of Evidence Appraisal during journal-club meetings. Results: A total of 43 articles related to competency (n = 8), knowledge acquisition and personality characteristics (n = 8), learning style (n = 5), preceptor development (n = 7), and Precepting Programs (n = 14). Conclusions: A significant clinical gap existed between the scientific evidence and actual precepting practice of experienced nurses at the Burn Center. Based on this extensive review of the literature, it was determined that a sufficient evidence base existed for development of an evidence-based Precepting Program. (C) 2013 Elsevier Ltd and ISBI. All rights reserved. C1 [Mann-Salinas, Elizabeth; Hayes, Elizabeth; Robbins, Johnnie] US Army Inst Surg Res, Army Burn Ctr, San Antonio, TX USA. [Sabido, Jean] Army Med Dept Ctr & Sch, San Antonio, TX USA. [Feider, Laura; Allen, David] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Yoder, Linda] Univ Texas Austin, Sch Nursing, Austin, TX 78712 USA. RP Mann-Salinas, E (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Houston, TX 78234 USA. EM Elizabeth.A.Mannsalinas.mil@mail.mil FU TriService Nursing Research Program, Medical Research and Material Command, Ft. Detrick, MD [N12-P04, HT9404-12-1-TS08] FX TriService Nursing Research Program (N12-P04; HT9404-12-1-TS08) Medical Research and Material Command, Ft. Detrick, MD. NR 61 TC 3 Z9 3 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD MAY PY 2014 VL 40 IS 3 BP 374 EP 387 DI 10.1016/j.burns.2013.11.008 PG 14 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AE2FA UT WOS:000333787500002 PM 24331408 ER PT J AU Hooper, JW Moon, JE Paolino, KM Newcomer, R McLain, DE Josleyn, M Hannaman, D Schmaljohn, C AF Hooper, J. W. Moon, J. E. Paolino, K. M. Newcomer, R. McLain, D. E. Josleyn, M. Hannaman, D. Schmaljohn, C. TI A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation SO CLINICAL MICROBIOLOGY AND INFECTION LA English DT Article DE electroporation; DNA vaccine; Hantavirus; haemorrhagic fever with renal syndrome ID ENCEPHALITIS-VIRUS; PROTECTS HAMSTERS; NONHUMAN-PRIMATES; ANDES VIRUS; CHALLENGE; VACCINATION; MICE; IMMUNOGENICITY; ELICITS; CANCER AB Haemorrhagic fever with renal syndrome (HFRS) is endemic in Asia, Europe and Scandinavia, and is caused by infection with the hantaviruses Hantaan (HTNV), Seoul (SEOV), Puumala (PUUV), or Dobrava (DOBV) viruses. We developed candidate DNA vaccines for HFRS expressing the Gn and Gc genes of HTNV or PUUV and evaluated them in an open-label, single-centre Phase 1 study. Three groups of nine participants each were vaccinated on days 0, 28 and 56 with the DNA vaccines for HTNV, PUUV, or a mixture of both vaccines using the Ichor Medical Systems TriGrid (TM) Intramuscular Delivery System. All vaccinations consisted of a total dose of 2.0mg DNA in an injected volume of 1mL saline. For the combined vaccine, the mixture contained equal amounts (1.0mg) of each DNA vaccine. There were no study-related serious adverse events. Neutralizing antibody responses were measured by a plaque reduction neutralization test. Neutralizing antibody responses were detected in five of nine and seven of nine individuals who completed all three vaccinations with the HTNV or PUUV DNA vaccines, respectively. In the combined vaccine group, seven of the nine volunteers receiving all three vaccinations developed neutralizing antibodies to PUUV. The three strongest responders to the PUUV vaccine also had strong neutralizing antibody responses to HTNV. These results demonstrate that the HTNV and PUUV DNA vaccines delivered by electroporation separately or as a mixture are safe. In addition, both vaccines were immunogenic, although when mixed together, more participants responded to the PUUV than to the HTNV DNA vaccine. C1 [Hooper, J. W.; Josleyn, M.; Schmaljohn, C.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Moon, J. E.; Paolino, K. M.; Newcomer, R.] Walter Reed Army Inst Res, Silver Spring, MD USA. [McLain, D. E.] Walker Downey & Associates Inc, Verona, WI USA. [Hannaman, D.] Ichor Med Syst Inc, San Diego, CA USA. RP Schmaljohn, C (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@us.army.mil RI Moon, James/B-6810-2011; OI Moon, James/0000-0002-9274-4554; Hooper, Jay/0000-0002-4475-0415 FU US Army Medical Infectious Diseases Research Program; Medical Research and Material Command FX The investigators thank all of the study volunteers for their participation. We are also grateful to the staff of the Walter Reed Army Institute of Research Clinical Trials Center for their assistance in completing this study. We thank Cindy Rossi and Tamara Clements for ELISA prescreens; Ed Brown and Rhonda DaSilva for regulated studies support; Ryan Adams for regulatory advice; Debbie Coates for quality assurance reviews; Julie Newhart for project management; Cyndi Donovan for clinical monitoring; and the US Army Medical Infectious Diseases Research Program and the Medical Research and Material Command for funding this study. To ensure compliance with these procedures and to assess the adequacy of quality control procedures, the WRAIR Quality Office performed audits of the study site on behalf of the USAMRIID Quality Assurance and Regulatory Compliance Office (QARCO). Quality assurance responsibilities included a visit during the study and after the last participant had completed the study. We also thank Ms Jennifer Secula for a critical reading of the manuscript and her attention to the accuracy of the data presented. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 22 TC 11 Z9 13 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1198-743X EI 1469-0691 J9 CLIN MICROBIOL INFEC JI Clin. Microbiol. Infect. PD MAY PY 2014 VL 20 SU 5 SI SI BP 110 EP 117 DI 10.1111/1469-0691.12553 PG 8 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA AE1CR UT WOS:000333704300018 PM 24447183 ER PT J AU Hall, DM Lazarus, ED Swannack, TM AF Hall, Damon M. Lazarus, Eli D. Swannack, Todd M. TI Strategies for communicating systems models SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Communication; Cultural models; Mental models; Policy; Stakeholders; Sustainability science ID SUSTAINABILITY SCIENCE; CHESAPEAKE BAY; CULTURAL MODEL; MANAGEMENT; RESTORATION; ECOSYSTEMS; ENGAGEMENT; SIMULATION; ECOLOGY AB Sustainable environmental policies are rooted in knowledge and assumptions that decision-making authorities hold regarding specific social ecological settings. These decision makers are increasingly informed by systems models. Diverse audiences for environmental science and sustainability policies magnify the importance of clear model communication. This essay offers a summary of best communication practices for situations in which bridging modelers' and non-modelers' conceptions of a given system their respective mental models is a principal challenge. Synthesizing social research from technical communication, educational psychology, and science communication disciplines, we discuss common areas of confusion in comprehending and explaining complex information, and present strategies model developers can use to ensure their model presentations are understandable and meaningful to audiences. We argue that accessible and socially adoptable explanations benefit from modelers listening to target audiences and anticipating how and why audiences may fail to understand aspects of a model. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Hall, Damon M.] St Louis Univ, Ctr Sustainabil, St Louis, MO 63108 USA. [Lazarus, Eli D.] Cardiff Univ, Sch Earth & Ocean Sci, Environm Dynam Lab, Cardiff CF10 3AT, S Glam, Wales. [Swannack, Todd M.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Hall, DM (reprint author), St Louis Univ, Ctr Sustainabil, Des Peres Hall,Suite 203E,3694 West Pine Mall, St Louis, MO 63108 USA. EM damon.hall1@gmail.com; LazarusED@cardiff.ac.uk; todd.m.swannack@usace.army.mil OI Hall , Damon/0000-0002-1232-119X; Lazarus, Eli/0000-0003-2404-9661 FU U.S. National Park Service; U.S. National Science Foundation [EPS-0904155]; Senator George J. Mitchell Center for Environmental and Watershed Research at the University of Maine FX This work was made possible in part by a grant from the U.S. National Park Service and U.S. National Science Foundation (award EPS-0904155) for the Sustainability Solutions Initiative at the University of Maine and additional funds from the Senator George J. Mitchell Center for Environmental and Watershed Research at the University of Maine. The authors would also like to thank Brian Fath, Bill Grant, Tarzan Legovic, Tarla Peterson, Candice Piercy, Molly Reif, and the reviewers, whose comments helped this paper evolve. NR 76 TC 9 Z9 9 U1 1 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD MAY PY 2014 VL 55 BP 70 EP 76 DI 10.1016/j.envsoft.2014.01.007 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA AE5BW UT WOS:000334003800006 ER PT J AU Rathbone, CR Guda, T Singleton, BM Oh, DS Appleford, MR Ong, JL Wenke, JC AF Rathbone, C. R. Guda, T. Singleton, B. M. Oh, D. S. Appleford, M. R. Ong, J. L. Wenke, J. C. TI Effect of cell-seeded hydroxyapatite scaffolds on rabbit radius bone regeneration SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE hydroxyapatite; bone; mesenchymal stem cells; rabbit radius; callus ID MARROW STROMAL CELLS; TISSUE-ENGINEERED BONE; BETA-TRICALCIUM PHOSPHATE; MESENCHYMAL STEM-CELLS; CRITICAL-SIZE DEFECTS; SEEDING DENSITY; IN-VIVO; REPAIR; MODEL; RECRUITMENT AB Highly porous hydroxyapatite (HA) scaffolds were developed as bone graft substitutes using a template coating process, characterized, and seeded with bone marrow-derived mesenchymal stem cells (BMSCs). To test the hypothesis that cell-seeded HA scaffolds improve bone regeneration, HA scaffolds without cell seeding (HA-empty), HA scaffolds with 1.5 x 10(4) BMSCs (HA-low), and HA scaffolds with 1.5 x 10(6) BMSCs (HA-high) were implanted in a 10-mm rabbit radius segmental defect model for 4 and 8 weeks. Three different fluorochromes were administered at 2, 4, and 6 weeks after implantation to identify differences in temporal bone growth patterns. It was observed from fluorescence histomorphometry analyses that an increased rate of bone infiltration occurred from 0 to 2 weeks (p < 0.05) of implantation for the HA-high group (2.9 +/- 0.5 mm) as compared with HA-empty (1.8 +/- 0.8 mm) and HA-low (1.3 +/- 0.2 mm) groups. No significant differences in bone formation within the scaffold or callus formation was observed between all groups after 4 weeks, with a significant increase in bone regenerated for all groups from 4 to 8 weeks (28.4% across groups). Although there was no difference in bone formation within scaffolds, callus formation was significantly higher in HA-empty scaffolds (100.9 +/- 14.1 mm(3)) when compared with HA-low (57.8 +/- 7.3 mm(3); p <= 0.003) and HA-high (69.2 +/- 10.4 mm(3); p <= 0.02) after 8 weeks. These data highlight the need for a better understanding of the parameters critical to the success of cell-seeded HA scaffolds for bone regeneration. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1458-1466, 2014. C1 [Rathbone, C. R.; Guda, T.; Wenke, J. C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Guda, T.; Singleton, B. M.; Oh, D. S.; Appleford, M. R.; Ong, J. L.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Oh, D. S.] Columbia Univ, Dept Orthopaed Surg, Med Ctr, New York, NY USA. RP Rathbone, CR (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX USA. EM christopher.r.rathbone.civ@mail.mil FU U.S. Army Medical Research and Material Command; Department of Defense FX The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or Department of Defense. This study was supported by the U.S. Army Medical Research and Material Command and of the Department of Defense. NR 31 TC 5 Z9 6 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1549-3296 EI 1552-4965 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD MAY PY 2014 VL 102 IS 5 BP 1458 EP 1466 DI 10.1002/jbm.a.34834 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AD4JB UT WOS:000333215600027 PM 23776110 ER PT J AU Friedrich, EE Sun, LT Natesan, S Zamora, DO Christy, RJ Washburn, NR AF Friedrich, Emily E. Sun, Liang Tso Natesan, Shanmugasundaram Zamora, David O. Christy, Robert J. Washburn, Newell R. TI Effects of hyaluronic acid conjugation on anti-TNF-alpha inhibition of inflammation in burns SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE TNF-alpha; burn wound, inflammation; hyaluronic acid; wound healing ID NECROSIS-FACTOR-ALPHA; EXPRESSION; PROGRESSION; MACROPHAGE; MOLECULES; RABBIT; WOUNDS; CELLS; RATS; TIME AB Biomaterials capable of neutralizing specific cytokines could form the basis for treating a broad range of conditions characterized by intense, local inflammation. Severe burns, spanning partial- to full-thickness of the dermis, can result in complications due to acute inflammation that contributes to burn progression, and early mediation may be a key factor in rescuing thermally injured tissue from secondary necrosis to improve healing outcomes. In this work, we examined the effects on burn progression and influence on the inflammatory microenvironment of topical application of anti-tumor necrosis factor-alpha (anti-TNF-alpha) alone, mixed with hyaluronic acid (HA) or conjugated to HA. We found that non-conjugated anti-TNF-alpha decreased macrophage infiltration to a greater extent than that conjugated to HA; however, there was little effect on the degree of progression or IL-1 beta levels. A simple transport model is proposed to analyze the results, which predicts qualitative and quantitative differences between untreated burn sites and those treated with the conjugates. Our results indicate that conjugation of anti-TNF-alpha to high molecular weight HA provides sustained, local modulation of the post-injury inflammatory responses compared to direct administration of non-conjugated antibodies. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1527-1536, 2014. C1 [Friedrich, Emily E.; Sun, Liang Tso; Washburn, Newell R.] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA. [Natesan, Shanmugasundaram; Zamora, David O.; Christy, Robert J.] United States Army, Inst Surg Res, Ft Sam Houston, TX USA. [Washburn, Newell R.] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA. [Washburn, Newell R.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA. RP Washburn, NR (reprint author), Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA. EM washburn@andrew.cmu.edu FU Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0032]; National Institutes of Health [R43GM085897]; 3M Non-Tenured Faculty GrantThe Wallace H. Coulter Foundation Translational Research Award program; Heinz Endowment [C1747] FX Contract grant sponsor: Armed Forces Institute of Regenerative Medicine; contract grant number: W81XWH-08-2-0032; Contract grant sponsor: National Institutes of Health; contract grant number: R43GM085897; Contract grant sponsor: 3M Non-Tenured Faculty GrantThe Wallace H. Coulter Foundation Translational Research Award program to (NRW); Contract grant sponsor: Heinz Endowment; contract grant number: C1747 NR 39 TC 8 Z9 9 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1549-3296 EI 1552-4965 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD MAY PY 2014 VL 102 IS 5 BP 1527 EP 1536 DI 10.1002/jbm.a.34829 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AD4JB UT WOS:000333215600034 PM 23765644 ER PT J AU Mondello, S Schmid, K Berger, RP Kobeissy, F Italiano, D Jeromin, A Hayes, RL Tortella, FC Buki, A AF Mondello, Stefania Schmid, Kara Berger, Rachel P. Kobeissy, Firas Italiano, Domenico Jeromin, Andreas Hayes, Ronal L. Tortella, Frank C. Buki, Andras TI The Challenge of Mild Traumatic Brain Injury: Role of Biochemical Markers in Diagnosis of Brain Damage SO MEDICINAL RESEARCH REVIEWS LA English DT Review DE mild TBI; diagnostic; biomarkers; traumatic brain injury; concussion ID NEURON-SPECIFIC-ENOLASE; MINOR HEAD-INJURY; DIFFUSE AXONAL INJURY; FIBRILLARY ACIDIC PROTEIN; SERUM BIOMARKER CONCENTRATIONS; COMPUTED-TOMOGRAPHY FINDINGS; OPERATION-ENDURING-FREEDOM; AMYLOID PRECURSOR PROTEIN; POST-CONCUSSION SYMPTOMS; C-TERMINAL HYDROLASE AB During the past decade there has been an increasing recognition of the incidence of mild traumatic brain injury (mTBI) and a better understanding of the subtle neurological and cognitive deficits that may result from it. A substantial, albeit suboptimal, effort has been made to define diagnostic criteria for mTBI and improve diagnostic accuracy. Thus, biomarkers that can accurately and objectively detect brain injury after mTBI and, ideally, aid in clinical management are needed. In this review, we discuss the current research on serum biomarkers for mTBI including their rationale and diagnostic performances. Sensitive and specific biomarkers reflecting brain injury can provide important information regarding TBI pathophysiology and serve as candidate markers for predicting abnormal computed tomography findings and/or the development of residual deficits in patients who sustain an mTBI. We also outline the roles of biomarkers in settings of specific interest including pediatric TBI, sports concussions and military injuries, and provide perspectives on the validation of such markers for use in the clinic. Finally, emerging proteomics-based strategies for identifying novel markers will be discussed. C1 [Mondello, Stefania] Univ Messina, Dept Neurosci, I-98125 Messina, Italy. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. [Berger, Rachel P.] Univ Pittsburgh, Med Ctr, Childrens Hosp Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15224 USA. [Kobeissy, Firas] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. [Italiano, Domenico] Univ Messina, Dept Clin & Expt Med & Pharmacol, I-98125 Messina, Italy. [Jeromin, Andreas] NextGen Sci Dx, Boston, MA 02210 USA. [Hayes, Ronal L.] Banyan Biomarkers Inc, Dept Clin Programs, Alachua, FL 32615 USA. [Buki, Andras] Univ Pecs, Dept Neurosurg, H-7624 Pecs, Hungary. [Buki, Andras] Hungarian Acad Sci, Clin Neurosci Image Ctr, H-7600 Pecs, Hungary. RP Mondello, S (reprint author), Univ Messina, Dept Neurosci, Via Consolare Valeria, I-98125 Messina, Italy. EM stm_mondello@hotmail.com RI Meijer, Anna/K-5118-2016; kobeissy, firas/E-7042-2017; OI kobeissy, firas/0000-0002-5008-6944; Mondello, Stefania/0000-0002-8587-3614 FU Developing Competitiveness of Universities in the South Trans-Q5 danubian Region [SROP-4.2.1.B-10/2/KONV-2010-0002]; Identification of new biomarkers, especially, regarding the toxicity of free iron deposition in the nervous system, iron toxicity-induced oxidative stress and innate immune reactions with translational investigations [SROP-4.2.2.A-11/1/KONV-2012-0017]; Clinical Neuroscience Image Center of Hungarian Academy of Sciences (HAS) FX This work was supported by Developing Competitiveness of Universities in the South Trans-Q5 danubian Region (SROP-4.2.1.B-10/2/KONV-2010-0002), by "Identification of new biomarkers, especially, regarding the toxicity of free iron deposition in the nervous system, iron toxicity-induced oxidative stress and innate immune reactions with translational investigations" (SROP-4.2.2.A-11/1/KONV-2012-0017) and by Clinical Neuroscience Image Center of Hungarian Academy of Sciences (HAS). NR 159 TC 22 Z9 22 U1 1 U2 44 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0198-6325 EI 1098-1128 J9 MED RES REV JI Med. Res. Rev. PD MAY PY 2014 VL 34 IS 3 BP 503 EP 531 DI 10.1002/med.21295 PG 29 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AE0SX UT WOS:000333677600003 PM 23813922 ER PT J AU Hu, YJ Lieser, AC Saengdeejing, A Liu, ZK Kecskes, LJ AF Hu, Y. J. Lieser, A. C. Saengdeejing, A. Liu, Z. K. Kecskes, L. J. TI Glass formability of W-based alloys through thermodynamic modeling: W-Fe-Hf-Pd-Ta and W-Fe-Si-C SO INTERMETALLICS LA English DT Article DE Glasses, metallic; Phase diagrams; Phase diagram, prediction (including CALPHAD); Ab-initio calculations ID PHASE-DIAGRAM; METALLIC GLASSES; SYSTEM; TEMPERATURE; SCIENCE AB Computational thermodynamics, based on the CALculation of PHAse Diagram (CALPHAD) method, can be an efficient way to predict phase stabilities in multi-component engineering materials. By calculating the stability of the liquid phase at low temperatures, this method could be a useful and cost-effective tool for the design of bulk metallic glasses. Based on the thermodynamic modeling of the constituent binary and ternary systems of W with Fe, Hf, Pd, Ta, Si, or C, thermodynamic databases are built to search for W-based metallic glasses in these alloying systems. Modeling of intermetallic phases combines input from first-principles total energy calculations and predictions of finite temperature properties from the Debye-Grfineisen model. Several plausible W-rich glass-forming alloys are identified in the W-Fe-Si-C quaternary system. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hu, Y. J.; Lieser, A. C.; Saengdeejing, A.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Kecskes, L. J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Hu, YJ (reprint author), Penn State Univ, Dept Mat Sci & Engn, 304 Steidle Bldg, University Pk, PA 16802 USA. EM thesunnyhouse@gmail.com RI Kecskes, Laszlo/F-6880-2014; Liu, Zi-Kui/A-8196-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; Liu, Zi-Kui/0000-0003-3346-3696 NR 26 TC 1 Z9 1 U1 0 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0966-9795 EI 1879-0216 J9 INTERMETALLICS JI Intermetallics PD MAY PY 2014 VL 48 SI SI BP 79 EP 85 DI 10.1016/j.intermet.2013.10.010 PG 7 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA AD8AW UT WOS:000333489900011 ER PT J AU Coletti, F Benson, MJ Sagues, AL Miller, BH Fahrig, R Eaton, JK AF Coletti, Filippo Benson, Michael J. Sagues, Alexander L. Miller, Benjamin H. Fahrig, Rebecca Eaton, John K. TI Three-Dimensional Mass Fraction Distribution of a Spray Measured by X-Ray Computed Tomography SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article ID FUEL SPRAYS; RADIOGRAPHY; MECHANICS AB In order to design a spraying system with the desired characteristics, the atomization process has to be understood in detail, including the primary breakup of the liquid core. Accurate prediction of primary breakup is a major barrier to computer-based analysis of spray combustion. The development of models is hindered by the lack of validation data in a region where the fluid is dense, and optical access is therefore limited. The present experimental study is aimed at probing the spray structure by means of X-ray computed tomography (CT). A full-cone atomizer (0.79 mm orifice diameter) spraying in air at ambient pressure is investigated as a proof of concept. A mixture of water and iodine is used as the working fluid, providing elevated X-ray absorption and therefore, improved signal-to-noise ratio. Several hundreds of X-ray projections are acquired as the spraying atomizer is rotated in front of the detector. Standard software for medical imaging is used to reconstruct the three-dimensional time-averaged distribution of liquid mass fraction in the full field of view, from the intact liquid core to the dilute spray region. A spatial resolution of 0.6 mm is obtained along the spraying direction, while the resolution is 0.3 mm in the other two directions. Significant asymmetries in the structure of the spray are revealed. C1 [Coletti, Filippo; Eaton, John K.] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. [Benson, Michael J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Sagues, Alexander L.; Miller, Benjamin H.] US Mil Acad, West Point, NY 10996 USA. [Fahrig, Rebecca] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA. RP Coletti, F (reprint author), Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. EM colettif@stanford.edu; michael.benson@usma.edu; Alexander.Sagues@usma.edu; Benjamin.Miller@usma.edu; fahrig@stanford.edu; eatonj@stanford.edu OI Miller, Benjamin/0000-0003-1647-0122 FU U.S. Army Research Office [W911NF-13-2-0048] FX This work was funded by the U.S. Army Research Office (contract number W911NF-13-2-0048). The views expressed herein are those of the authors and do not purport to reflect the position of the Department of the Army, or the Department of Defense. We thank Dr. Chol-Bum "Mike" Kweon, director of the Combustion Research Center at the Army Research Laboratory (Aberdeen, MD), for the continuous support and many useful discussions. The assistance and expertise of Dr. Waldo Hinshaw (Radiology Department, Stanford, CA) were instrumental for performing the present measurements. NR 27 TC 6 Z9 6 U1 0 U2 10 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 EI 1528-8919 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD MAY PY 2014 VL 136 IS 5 AR 051508 DI 10.1115/1.4026245 PG 8 WC Engineering, Mechanical SC Engineering GA AD2CT UT WOS:000333041400009 ER PT J AU Owens, GP Held, P Blackburn, L Auerbach, JS Clark, AA Herrera, CJ Cook, J Stuart, GL AF Owens, Gina P. Held, Philip Blackburn, Laura Auerbach, John S. Clark, Allison A. Herrera, Catherine J. Cook, Jerome Stuart, Gregory L. TI Differences in Relationship Conflict, Attachment, and Depression in Treatment-Seeking Veterans With Hazardous Substance Use, PTSD, or PTSD and Hazardous Substance Use SO JOURNAL OF INTERPERSONAL VIOLENCE LA English DT Article DE war; PTSD; alcohol and drugs; violence ID POSTTRAUMATIC-STRESS-DISORDER; HARMFUL ALCOHOL-CONSUMPTION; COLLABORATIVE PROJECT; VIETNAM VETERANS; ADULT ATTACHMENT; MENTAL-DISORDERS; WAR CAPTIVITY; HEALTH-CARE; TRAUMA; AFGHANISTAN AB Veterans (N = 133) who were seeking treatment in either the Posttraumatic Stress Program or Substance Use Disorders Program at a Veterans Affairs Medical Center (VAMC) and, based on self-report of symptoms, met clinical norms for posttraumatic stress disorder (PTSD) or hazardous substance use (HSU) completed a survey related to relationship conflict behaviors, attachment styles, and depression severity. Participants were grouped into one of three categories on the basis of clinical norm criteria: PTSD only, HSU only, and PTSD + HSU. Participants completed the PTSD Checklist-Military, Experiences in Close Relationships Scale-Short Form, Center for Epidemiologic Studies-Depression scale, Alcohol Use Disorders Identification Test, Drug Use Disorders Identification Test, and Psychological Aggression and Physical Violence subscales of the Conflict Tactics Scale. Most participants were male and Caucasian. Significant differences were found between groups on depression, avoidant attachment, psychological aggression perpetration and victimization, and physical violence perpetration and victimization. Post hoc analyses revealed that the PTSD + HSU group had significantly higher levels of depression, avoidant attachment, and psychological aggression than the HSU only group. The PTSD + HSU group had significantly higher levels of physical violence than did the PTSD only group, but both groups had similar mean scores on all other variables. Potential treatment implications are discussed. C1 [Owens, Gina P.; Stuart, Gregory L.] Univ Tennessee, Knoxville, TN 37996 USA. [Held, Philip; Blackburn, Laura] Univ Tennessee, Doctoral Program Counseling Psychol, Knoxville, TN 37996 USA. [Auerbach, John S.] North Florida South Georgia Vet Hlth Syst, Gainesville, FL USA. [Clark, Allison A.] Naval Hosp Camp Lejeune, US Navy, Camp Lejeune, NC USA. [Herrera, Catherine J.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Cook, Jerome] James H Quillen VA Med Ctr, Subst Use Disorders Program, Mountain Home, TN USA. RP Owens, GP (reprint author), Univ Tennessee, Dept Psychol, Knoxville, TN 37996 USA. EM gowens4@utk.edu NR 47 TC 2 Z9 2 U1 3 U2 23 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0886-2605 EI 1552-6518 J9 J INTERPERS VIOLENCE JI J. Interpers. Violence PD MAY PY 2014 VL 29 IS 7 BP 1318 EP 1337 DI 10.1177/0886260513506274 PG 20 WC Criminology & Penology; Family Studies; Psychology, Applied SC Criminology & Penology; Family Studies; Psychology GA AD5WJ UT WOS:000333323600008 PM 24255069 ER PT J AU Pichugin, A Steers, N De La Vega, P Krzych, U AF Pichugin, Alexander Steers, Nick De La Vega, Patricia Krzych, Urszula TI Although the induction of INF-gamma+CD8 T cells by radiation-attenuated Plasmodium berghei sporozoites is TAP-independent, the recall of protective effector CD8 T cells during infection requires TAP machinery SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Pichugin, Alexander; Steers, Nick; De La Vega, Patricia; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2014 VL 192 SU 1 MA MPF6P.740 PG 2 WC Immunology SC Immunology GA V44RB UT WOS:000209765006070 ER PT J AU Powell, T Tang, J Jacobs, A DeRome, M Palath, N Cardenas, E Boyd, J Nardin, E Kaba, S Lanar, D AF Powell, Thomas Tang, Jie Jacobs, Andrea DeRome, Mary Palath, Naveen Cardenas, Edwin Boyd, James Nardin, Elizabeth Kaba, Stephen Lanar, David TI Parasite-neutralizing and protective antibody response in macaques immunized with synthetic LbL microparticle vaccines containing the conserved T1BT*epitope of plasmodium falciparum SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Powell, Thomas; Tang, Jie; Jacobs, Andrea; DeRome, Mary; Palath, Naveen; Cardenas, Edwin; Boyd, James] Artificial Cell Technol, New Haven, CT USA. [Nardin, Elizabeth] NYU, Dept Microbiol, Div Med Parasitol, New York, NY 10016 USA. [Kaba, Stephen; Lanar, David] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2014 VL 192 SU 1 MA VAC7P.976 PG 1 WC Immunology SC Immunology GA V44RB UT WOS:000209765002057 ER PT J AU Niu, XF Ye, HW Xia, T Winkler, M Gagnon, D Wang, WL AF Niu, Xiaofeng Ye, Hongwei Xia, Ting Winkler, Mark Gagnon, Daniel Wang, Wenli TI Count-rate adaptive detector efficiency normalization for quantitative 3D PET reconstruction SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract CT Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI) CY JUN 07-11, 2014 CL St Louis, MO SP Soc Nucl Med & Mol Imaging C1 [Niu, Xiaofeng; Ye, Hongwei; Xia, Ting; Gagnon, Daniel; Wang, Wenli] USA, Toshiba Med Res Inst, Vernon Hills, IL USA. [Winkler, Mark] Steinberg Diagnost Med Imaging, Las Vegas, NV USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA SN 0161-5505 EI 1535-5667 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 2014 VL 55 SU 1 MA 2101 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CR6FA UT WOS:000361438103272 ER PT J AU Salem, TE Wood, RA AF Salem, Thomas E. Wood, Robert A. TI 1000-H Evaluation of a 1200-V, 880-A All-SiC Dual Module SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE Electric vehicles; high-power; inverter; metal oxide-semiconductor field-effect transistors (MOSFET); silicon carbide ID POWER; DEVICES; RELIABILITY; PERFORMANCE; SYSTEMS; DIODES; MOSFET AB The commercial availability of silicon-carbide (SiC) power devices began over a decade ago with the introduction of SiC diodes and has expanded in complexity the past few years to include the offering of SiC transistors and power modules. Recently, characterization of a 1200-V, 800-A all-SiC dual module designed for large-scale electric military vehicle applications has been reported. This paper expands on the previous work by presenting details and results obtained from a long-term evaluation of a similar module. The module has successfully operated in an experimental circuit at a switching frequency of 10 kHz while running vehicle load profiles for over 1000 h and exhibited little change in device characteristics. Of all measured characteristics, none had a significant unfavorable change greater than 10% from its initial value. The 1000 h of circuit operation represents 11 783 miles of use or over half of the expected lifecycle in a military vehicle traction inverter. C1 [Salem, Thomas E.] US Naval Acad, Annapolis, MD 21402 USA. [Wood, Robert A.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Salem, TE (reprint author), US Naval Acad, Annapolis, MD 21402 USA. EM salem@usna.edu; robert.a.wood98.civ@mail.mil NR 27 TC 12 Z9 13 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-8993 EI 1941-0107 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD MAY PY 2014 VL 29 IS 5 SI SI BP 2192 EP 2198 DI 10.1109/TPEL.2013.2265661 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 293RN UT WOS:000329991500006 ER PT J AU Vincenti, MA de Ceglia, D Grande, M D'Orazio, A Scalora, M AF Vincenti, M. A. de Ceglia, D. Grande, M. D'Orazio, A. Scalora, M. TI Third-harmonic generation in one-dimensional photonic crystal with graphene-based defect SO PHYSICAL REVIEW B LA English DT Article ID ATOMIC-LAYER GRAPHENE; 2ND-HARMONIC GENERATION; SATURABLE ABSORBER; ABSORPTION; LASER; METAMATERIALS; TRANSPARENT; PLASMONICS; ELECTRODES; FILMS AB Third-harmonic generation may be dramatically enhanced in monolayer graphene by inserting it in a properly designed structure. In addition, placing graphene within the defect layer of an asymmetric, one-dimensional photonic crystal triggers nearly 100% narrowband absorption. We demonstrate that the improved field localization within the defect state enhances third-harmonic generation by nearly five orders of magnitude compared with bare monolayer graphene. Saturation of the third-order susceptibility plays a role at both fundamental and third-harmonic frequencies. We discuss the benefits of including graphene within the structure for both signals. C1 [Vincenti, M. A.; de Ceglia, D.] AMRDEC, Natl Res Council, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Grande, M.; D'Orazio, A.] Politecn Bari, Dipartimento Ingn Elettr & Informaz DEI, I-70125 Bari, Italy. [Scalora, M.] US Army, Res Dev & Engn Command RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), AMRDEC, Natl Res Council, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM maria.vincenti@us.army.mil RI Petruzzelli, Vincenzo/H-5188-2012 OI Petruzzelli, Vincenzo/0000-0001-6921-9981 FU U.S. Army International Technology Center Atlantic [W911NF-13-1-0434] FX This research was performed while the authors M.A. Vincenti and D. de Ceglia held National Research Council Research Associateship awards at the U. S. Army Aviation and Missile Research Development and Engineering Center. M. Grande thanks the U.S. Army International Technology Center Atlantic for financial support (Grant No. W911NF-13-1-0434). NR 42 TC 6 Z9 6 U1 2 U2 46 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD APR 30 PY 2014 VL 89 IS 16 AR 165139 DI 10.1103/PhysRevB.89.165139 PG 6 WC Physics, Condensed Matter SC Physics GA AH0GP UT WOS:000335797600004 ER PT J AU Close, R Gader, P Wilson, J AF Close, Ryan Gader, Paul Wilson, Joseph TI Hyperspectral unmixing using macroscopic and microscopic mixture models SO JOURNAL OF APPLIED REMOTE SENSING LA English DT Article DE hyperspectral; nonlinear mixing; macroscopic mixtures; microscopic mixtures; intimate mixing ID MANIFOLD COORDINATE REPRESENTATIONS; BIDIRECTIONAL REFLECTANCE SPECTROSCOPY; PRINCIPAL-COMPONENTS-ANALYSIS; BATHYMETRIC RETRIEVAL; QUANTITATIVE-ANALYSIS; IMAGERY; SPECTRA; DIMENSIONALITY; ENDMEMBERS; VEGETATION AB Macroscopic and microscopic mixture models and algorithms for hyperspectral unmixing are presented. Unmixing algorithms are derived from an objective function. The objective function incorporates the linear mixture model for macroscopic unmixing and a nonlinear mixture model for microscopic unmixing. The nonlinear mixture model is derived from a bidirectional reflectance distribution function for microscopic mixtures. The algorithm is designed to unmix hyperspectral images composed of macroscopic or microscopic mixtures. The mixture types and abundances at each pixel can be estimated directly from the data without prior knowledge of mixture types. Endmembers can also be estimated. Results are presented using synthetic data sets of macroscopic and microscopic mixtures and using well-known, well-characterized laboratory data sets. The unmixing accuracy of this new physics-based algorithm is compared to linear methods and to results published for other nonlinear models. The proposed method achieves the best unmixing accuracy. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Close, Ryan] US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. [Gader, Paul; Wilson, Joseph] Univ Florida, Gainesville, FL 32611 USA. RP Close, R (reprint author), US Army, RDECOM, CERDEC, NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 87 TC 0 Z9 0 U1 1 U2 8 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1931-3195 J9 J APPL REMOTE SENS JI J. Appl. Remote Sens. PD APR 29 PY 2014 VL 8 AR 083642 DI 10.1117/1.JRS.8.083642 PG 16 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA AG8CM UT WOS:000335646400001 ER PT J AU Hire, JM Evanson, JL Johnson, PC Zumbrun, SD Guyton, MK McPherson, JC Bojescul, JA AF Hire, Justin M. Evanson, J. Lee Johnson, Peter C. Zumbrun, Steven D. Guyton, M. Kelly McPherson, James C., III Bojescul, John A. TI Variance of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) concentrations in activated, concentrated platelets from healthy male donors SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH LA English DT Article DE Platelet-rich plasma (PRP); MMP; TIMP; ADAMTS13; Wound healing; Tissue remodeling ID RICH PLASMA; SPORTS-MEDICINE; GROWTH-FACTOR; MEGAKARYOCYTES; EFFICACY; TENDON AB Background: The use of autologous blood concentrates, such as activated, concentrated platelets, in orthopaedic clinical applications has had mixed results. Research on this topic has focused on growth factors and cytokines, with little directed towards matrix metalloproteinases (MMPs) which are involved in post-wound tissue remodeling. Methods: In this study, the authors measured the levels of MMP-2, MMP-9 and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), in activated platelets derived from blood of healthy, male volunteers (n = 92), 19 to 60 years old. The levels of the natural inhibitors of these proteases, tissue inhibitor of metalloproteinase 1 (TIMP-1), TIMP-2 and TIMP-4 were also assessed. Results: Notably, there was no significant change in concentration with age in four of six targets tested. However, TIMP-2 and TIMP-4 demonstrated a statistically significant increase in concentration for subjects older than 30 years of age compared to those 30 years and younger (P = 0.04 and P = 0.04, respectively). Conclusion: TIMP-2 and TIMP-4 are global inhibitors of MMPs, including MMP-2 (Gelatinase A). MMP-2 targets native collagens, gelatin and elastin to remodel the extracellular matrix during wound healing. A decreased availability of pharmacologically active MMP-2 may diminish the effectiveness of the use of activated, concentrated platelets from older patients, and may also contribute to longer healing times in this population. C1 [Hire, Justin M.; Evanson, J. Lee; Johnson, Peter C.; Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA. [Zumbrun, Steven D.; Guyton, M. Kelly; McPherson, James C., III] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Hire, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM justin.m.hire.mil@mail.mil FU Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center, Fort Gordon, GA FX The authors would like to thank Dr. Richard Topolski, PhD of Georgia Reagents University for providing statistical analysis and Dwight D. Eisenhower Army Medical Center Health Sciences Library for providing literature reviews. Funding for this study was provided by Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center, Fort Gordon, GA. No outside source of funding was received for this study. Each author certifies that he or she has no commercial associations (eg, consultancies, stockownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article. None of the authors received any funding for this study. NR 24 TC 1 Z9 2 U1 2 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1749-799X J9 J ORTHOP SURG RES JI J. Orthop. Surg. Res. PD APR 26 PY 2014 VL 9 AR 29 DI 10.1186/1749-799X-9-29 PG 6 WC Orthopedics SC Orthopedics GA AG5NS UT WOS:000335466300001 PM 24766991 ER PT J AU Kamau, E Alemayehu, S Feghali, KC Juma, DW Blackstone, GM Marion, WR Obare, P Ogutu, B Ockenhouse, CF AF Kamau, Edwin Alemayehu, Saba Feghali, Karla C. Juma, Dennis W. Blackstone, George M. Marion, William R. Obare, Peter Ogutu, Bernhards Ockenhouse, Christian F. TI Sample-ready multiplex qPCR assay for detection of malaria SO MALARIA JOURNAL LA English DT Article ID TIME PCR ASSAY; PLASMODIUM-FALCIPARUM; QUANTITATIVE PCR; IMPORTED MALARIA; DIAGNOSIS; AMPLIFICATION; MICROSCOPY; PARASITES; RNA; DNA AB Background: Microscopy and antigen detecting rapid diagnostic tests are the diagnostic tests of choice in management of clinical malaria. However, due to their limitations, the need to utilize more sensitive methods such as real-time PCR (qPCR) is evident as more studies are now utilizing molecular methods in detection of malaria. Some of the challenges that continue to limit the widespread utilization of qPCR include lack of assay standardization, assay variability, risk of contamination, and the need for cold-chain. Lyophilization of molecular assays can overcome some of these limitations and potentially enable widespread qPCR utilization. Methods: A recently published multiplex malaria qPCR assay was lyophilized by freezing drying into Sample-Ready T format (MMSR). MMSR assay contained all the required reagents for qPCR including primers and probes, requiring only the addition of water and sample to perform qPCR. The performance of the MMSR assay was compared to the non-freeze dried, "wet" assay. Stability studies were done by maintaining the MMSR assays at four different ambient temperatures of 4 degrees C, room temperature (RT), 37 degrees C and 42 degrees C over a period of 42 days, tested at seven-day intervals. Plasmodium falciparum and Plasmodium vivax DNAs were used for analysis of the MMSR assay either as single or mixed parasites, at two different concentrations. The CT values and the standard deviations (SD) were used in the analysis of the assay performance. Results: The limit of detection for the MMSR assay was 0.244 parasites/mu L for Plasmodium spp. (PLU) and P. falciparum (FAL) assay targets compared to "wet" assay which was 0.39 and 3.13 parasites/mu L for PLU and FAL assay targets, respectively. The MMSR assay performed with high efficiencies similar to those of the "wet" assay and was stable at 37 degrees C for 42 days, with estimated shelf-life of 5 months. When used to analyse field clinical samples, MMSR assay performed with 100% sensitivity and specificity compared to the "wet" assay. Conclusion: The MMSR assay has the same robust performance characteristics as the "wet" assay and is highly stable. Availability of MMSR assay allows flexibility and provides an option in choosing assay for malaria diagnostics depending on the application, needs and budget. C1 [Kamau, Edwin; Alemayehu, Saba; Feghali, Karla C.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Kamau, Edwin; Juma, Dennis W.; Obare, Peter; Ogutu, Bernhards] US Army, Kenya Med Res Inst KEMRI, Med Res Unit Kenya, GEIS Program, Kisumu, Kenya. [Blackstone, George M.; Marion, William R.] BioGX, Birmingham, AL USA. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM edwin.kamau@us.army.mil NR 24 TC 4 Z9 4 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 25 PY 2014 VL 13 AR 158 DI 10.1186/1475-2875-13-158 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AI1QT UT WOS:000336627200001 PM 24767409 ER PT J AU Mizanur, RM Stafford, RG Ahmed, SA AF Mizanur, Rahman M. Stafford, Robert G. Ahmed, S. Ashraf TI Cleavage of SNAP25 and Its Shorter Versions by the Protease Domain of Serotype A Botulinum Neurotoxin SO PLOS ONE LA English DT Article ID A LIGHT-CHAIN; ENDOPEPTIDASE ACTIVITY; SUBSTRATE RECOGNITION; IN-VITRO; PROTEOLYTIC ACTIVITY; CATALYTIC DOMAIN; ACTIVE-SITE; C-TERMINUS; INHIBITORS; IDENTIFICATION AB Various substrates, catalysts, and assay methods are currently used to screen inhibitors for their effect on the proteolytic activity of botulinum neurotoxin. As a result, significant variation exists in the reported results. Recently, we found that one source of variation was the use of various catalysts, and have therefore evaluated its three forms. In this paper, we characterize three substrates under near uniform reaction conditions using the most active catalytic form of the toxin. Bovine serum albumin at varying optimum concentrations stimulated enzymatic activity with all three substrates. Sodium chloride had a stimulating effect on the full length synaptosomal-associated protein of 25 kDa (SNAP25) and its 66-mer substrates but had an inhibitory effect on the 17-mer substrate. We found that under optimum conditions, full length SNAP25 was a better substrate than its shorter 66-mer or 17-mer forms both in terms of k(cat), K-m, and catalytic efficiency k(cat)/K-m. Assay times greater than 15 min introduced large variations and significantly reduced the catalytic efficiency. In addition to characterizing the three substrates, our results identify potential sources of variations in previous published results, and underscore the importance of using well-defined reaction components and assay conditions. C1 [Mizanur, Rahman M.; Stafford, Robert G.; Ahmed, S. Ashraf] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. RP Ahmed, SA (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. EM syed.a.ahmed.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense [JSTOCBD3.10012_06_RD_B, CB3849]; National Research Council (NRC) FX This project received support from the Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense (Grant #JSTOCBD3.10012_06_RD_B and CB3849). Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U. S. Army. The authors also acknowledge National Research Council (NRC) for their support to RMM through their research associateship program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 6 Z9 6 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 25 PY 2014 VL 9 IS 4 AR e95188 DI 10.1371/journal.pone.0095188 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI3CM UT WOS:000336736600005 PM 24769566 ER PT J AU Pegoraro, G Eaton, BP Ulrich, RL Lane, DJ Ojeda, JF Bavari, S DeShazer, D Panchal, RG AF Pegoraro, Gianluca Eaton, Brett P. Ulrich, Ricky L. Lane, Douglas J. Ojeda, Jenifer F. Bavari, Sina DeShazer, David Panchal, Rekha G. TI A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages SO BMC MICROBIOLOGY LA English DT Article DE Burkholderia pseudomallei; High Content imaging; phagocytosis; Multinucleated giant cells; Macrophages ID MITOGEN-STIMULATED LYMPHOCYTES; INTRACELLULAR LIFE-CYCLE; VI SECRETION; TUBERCULOUS-GRANULOMAS; INTERFERON-GAMMA; BLOOD MONOCYTES; DRUG DISCOVERY; HOST-CELLS; FUSION; MELIOIDOSIS AB Background: Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp genome encodes a repertoire of virulence factors, including the cluster 3 type III secretion system (T3SS-3), the cluster 1 type VI secretion system (T6SS-1), and the intracellular motility protein BimA, that enable the pathogen to invade both phagocytic and non-phagocytic cells. A unique hallmark of Bp infection both in vitro and in vivo is its ability to induce cell-to-cell fusion of macrophages to form multinucleated giant cells (MNGCs), which to date are semi-quantitatively reported following visual inspection. Results: In this study we report the development of an automated high-content image acquisition and analysis assay to quantitate the Bp induced MNGC phenotype. Validation of the assay was performed using T6SS-1 (Delta hcp1) and T3SS-3 (Delta bsaZ) mutants of Bp that have been previously reported to exhibit defects in their ability to induce MNGCs. Finally, screening of a focused small molecule library identified several Histone Deacetylase (HDAC) inhibitors that inhibited Bp-induced MNGC formation of macrophages. Conclusions: We have successfully developed an automated HCI assay to quantitate MNGCs induced by Bp in macrophages. This assay was then used to characterize the phenotype of the Bp mutants for their ability to induce MNGC formation and identify small molecules that interfere with this process. Successful application of chemical genetics and functional reverse genetics siRNA approaches in the MNGC assay will help gain a better understanding of the molecular targets and cellular mechanisms responsible for the MNGC phenotype induced by Bp, by other bacteria such as Mycobacterium tuberculosis, or by exogenously added cytokines. C1 [Pegoraro, Gianluca; Eaton, Brett P.; Ulrich, Ricky L.; Lane, Douglas J.; Ojeda, Jenifer F.; Bavari, Sina; DeShazer, David; Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA. [Pegoraro, Gianluca] Perkin Elmer, Waltham, MA 02451 USA. RP Panchal, RG (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA. EM rekha.g.panchal.civ@mail.mil OI Pegoraro, Gianluca/0000-0003-2843-9464 FU Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) JSTO-CBS [MEDBIO.02.10.RD.010]; Oak Ridge Institute for Science and Engineering FX We would like to thank Paul Brett and Mary Burtnick for providing pMo Delta bsaZ and Samuel Dickson for help with statistical analysis. This project was funded by the Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) JSTO-CBS. MEDBIO.02.10.RD.010 (to RGP). We would like to thank Oak Ridge Institute for Science and Engineering for participating in the Postgraduate Research Program at the U.S. Army Medical Research and Materiel Command. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. NR 75 TC 7 Z9 7 U1 2 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD APR 22 PY 2014 VL 14 AR 98 DI 10.1186/1471-2180-14-98 PG 14 WC Microbiology SC Microbiology GA AH2XP UT WOS:000335985700001 PM 24750902 ER PT J AU Singh, RS Tay, RY Chow, WL Tsang, SH Mallick, G Teo, EHT AF Singh, Ram Sevak Tay, Roland Yingjie Chow, Wai Leong Tsang, Siu Hon Mallick, Govind Teo, Edwin Hang Tong TI Band gap effects of hexagonal boron nitride using oxygen plasma SO APPLIED PHYSICS LETTERS LA English DT Article ID DOPED BN NANOTUBES; ELECTRONIC-STRUCTURE; ATMOSPHERIC-PRESSURE; GROWTH; CARBON; LAYERS AB Tuning of band gap of hexagonal boron nitride (h-BN) has been a challenging problem due to its inherent chemical stability and inertness. In this work, we report the changes in band gaps in a few layers of chemical vapor deposition processed as-grown h-BN using a simple oxygen plasma treatment. Optical absorption spectra show a trend of band gap narrowing monotonically from 6 eV of pristine h-BN to 4.31 eV when exposed to oxygen plasma for 12 s. The narrowing of band gap causes the reduction in electrical resistance by similar to 100 fold. The x-ray photoelectron spectroscopy results of plasma treated hexagonal boron nitride surface show the predominant doping of oxygen for the nitrogen vacancy. Energy sub-band formations inside the band gap of h-BN, due to the incorporation of oxygen dopants, cause a red shift in absorption edge corresponding to the band gap narrowing. (C) 2014 AIP Publishing LLC. C1 [Singh, Ram Sevak; Tay, Roland Yingjie; Chow, Wai Leong; Teo, Edwin Hang Tong] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore. [Tay, Roland Yingjie; Tsang, Siu Hon; Mallick, Govind] Nanyang Technol Univ, Temasek Labs, Singapore 639798, Singapore. [Mallick, Govind] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Teo, Edwin Hang Tong] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. RP Singh, RS (reprint author), Natl Inst Technol, Dept Phys, Kurukshetra 136119, Haryana, India. EM htteo@ntu.edu.sg RI Teo, Hang Tong Edwin/E-9437-2015 OI Teo, Hang Tong Edwin/0000-0003-0528-1764 FU NOVITAS, Nanoelectronics Center of Excellence, Nanyang Technological University FX The authors acknowledge the support from NOVITAS, Nanoelectronics Center of Excellence, Nanyang Technological University. NR 18 TC 10 Z9 10 U1 2 U2 48 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 21 PY 2014 VL 104 IS 16 AR 163101 DI 10.1063/1.4872318 PG 4 WC Physics, Applied SC Physics GA AG0ZX UT WOS:000335145600070 ER PT J AU Gubata, ME Piccirillo, AL Packnett, ER Niebuhr, DW Boivin, MR Cowan, DN AF Gubata, Marlene E. Piccirillo, Amanda L. Packnett, Elizabeth R. Niebuhr, David W. Boivin, Michael R. Cowan, David N. TI Risk Factors for Back-Related Disability in the US Army and Marine Corps SO SPINE LA English DT Article DE disability discharge; military personnel; back injury; epidemiology ID OPERATION IRAQI FREEDOM; FOLLOW-UP; ENDURING FREEDOM; UNITED-STATES; INJURY RATES; U.S. ARMY; PAIN; MILITARY; PREVALENCE; DISCHARGE AB Study Design. Matched case-control epidemiological study. Objective. To identify pre-enlistment, demographic, and servicerelated risk factors for back-related disability in enlisted US soldiers and Marines comparing those who were deployed with those who did not deploy during the service term. Summary of Background Data. Back conditions are a major cause of morbidity and lost work days in both the US working population and military. Back-related conditions are among the most prevalent causes of military disability discharge but little research has been conducted to identify risk factors for back-related disabilities in this population. Methods. Cases included enlisted Army and Marine Corps service members evaluated for back-related disability. Controls, frequency matched by year of military entrance and service, were selected from the enlisted service member population. Pre-enlistment demographic and medical characteristics, deployment, and ambulatory care data collected from existing military databases were used. Crude and adjusted odds of back-related disability were modeled using conditional logistic regression. Results. In adjusted models, service members who were overweight (odds ratio [OR]: 1.17; 95% confidence interval [95% CI]: 1.12-1.23) and obese (OR: 1.35; 95% CI: 1.26-1.44), between ages 25 and 29 years (OR: 1.23; 95% CI: 1.16-1.31), or 30 years or older (OR: 1.43; 95% CI: 1.34-1.52) at military entrance were at increased odds of a back-related disability. History of a back diagnosis at the pre-enlistment medical examination (OR: 1.94; 95% CI: 1.50-2.50) and deploying once (OR: 1.09; 95% CI: 1.05-1.14) were also associated with increased odds of a back-related disability. Conclusion. Enlisted soldiers and marines with back-related disabilities were more likely to be older, have a higher body mass index, have a history of pre-enlistment back conditions, and were deployed once, compared with controls without a back-related disability. Additional research is necessary to further examine the complex relationship between deployment to combat zones, onset of musculoskeletal symptoms, and back-related disability in soldiers and marines. C1 [Gubata, Marlene E.; Piccirillo, Amanda L.; Packnett, Elizabeth R.; Niebuhr, David W.; Boivin, Michael R.; Cowan, David N.] Walter Reed Army Inst Res, Prevent Med Program, Dept Epidemiol, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, Mission Solut & Serv, Herndon, VA USA. RP Packnett, ER (reprint author), Walter Reed Army Inst Res, Prevent Med Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM elizabeth.packnett1@us.army.mil FU Defense Health Program funds FX The Defense Health Program funds were received in support of this work. NR 43 TC 3 Z9 4 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 EI 1528-1159 J9 SPINE JI SPINE PD APR 20 PY 2014 VL 39 IS 9 BP 745 EP 753 DI 10.1097/BRS.0000000000000272 PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AJ1VN UT WOS:000337444100017 PM 24525986 ER PT J AU Sharma, D Amani, M Motayed, A Shah, PB Birdwell, AG Najmaei, S Ajayan, PM Lou, J Dubey, M Li, QL Davydov, AV AF Sharma, Deepak Amani, Matin Motayed, Abhishek Shah, Pankaj B. Birdwell, A. Glen Najmaei, Sina Ajayan, Pulickel M. Lou, Jun Dubey, Madan Li, Qiliang Davydov, Albert V. TI Electrical transport and low-frequency noise in chemical vapor deposited single-layer MoS2 devices SO NANOTECHNOLOGY LA English DT Article DE 2D materials; low-frequency noise; MoS2; flicker noise; generation recombination (G-R) noise ID FIELD-EFFECT TRANSISTORS; 1/F NOISE; MOLYBDENUM-DISULFIDE; GRAPHENE TRANSISTORS; INTEGRATED-CIRCUITS; MONOLAYER MOS2; FLICKER NOISE; LINEAR REGION; MOSFET; MODEL AB We have studied temperature-dependent (77-300 K) electrical characteristics and low-frequency noise (LFN) in chemical vapor deposited (CVD) single-layer molybdenum disulfide (MoS2) based back-gated field-effect transistors (FETs). Electrical characterization and LFN measurements were conducted on MoS2 FETs with Al2O3 top-surface passivation. We also studied the effect of top-surface passivation etching on the electrical characteristics of the device. Significant decrease in channel current and transconductance was observed in these devices after the Al2O3 passivation etching. For passivated devices, the two-terminal resistance variation with temperature showed a good fit to the activation energy model, whereas for the etched devices the trend indicated a hopping transport mechanism. A significant increase in the normalized drain current noise power spectral density (PSD) was observed after the etching of the top passivation layer. The observed channel current noise was explained using a standard unified model incorporating carrier number fluctuation and correlated surface mobility fluctuation mechanisms. Detailed analysis of the gate-referred noise voltage PSD indicated the presence of different trapping states in passivated devices when compared to the etched devices. Etched devices showed weak temperature dependence of the channel current noise, whereas passivated devices exhibited near-linear temperature dependence. C1 [Sharma, Deepak; Li, Qiliang] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Sharma, Deepak; Motayed, Abhishek; Davydov, Albert V.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. [Amani, Matin; Shah, Pankaj B.; Birdwell, A. Glen; Dubey, Madan] Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Motayed, Abhishek] Univ Maryland, IREAP, College Pk, MD 20742 USA. [Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. RP Sharma, D (reprint author), George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. EM amotayed@nist.gov RI Davydov, Albert/F-7773-2010; Li, Qiliang/B-2225-2015 OI Davydov, Albert/0000-0003-4512-2311; Li, Qiliang/0000-0001-9778-7695 FU National Science Foundation [ECCS-0112802]; US Army Research Laboratory (ARL); Welch Foundation [C-1716]; NSF [ECCS-1327093]; US Army Research Office MURI grant [W911NF-11-1-0362] FX This work is partially supported by National Science Foundation under grant no. ECCS-0112802. MA, PBS, AGB and MD acknowledge the support of the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. SN and JL would like to acknowledge Welch Foundation grant C-1716 and the NSF grant ECCS-1327093 for their support. SN and PMA would also like to thank the support of the US Army Research Office MURI grant W911NF-11-1-0362. The authors would also like to thank Dr Pani Varanasi, ARO for in-depth technical discussion on 2D atomic layers R&D. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the US Government. The US Government is authorized to reproduce or distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 31 TC 14 Z9 14 U1 13 U2 176 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD APR 18 PY 2014 VL 25 IS 15 AR 155702 DI 10.1088/0957-4484/25/15/155702 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA AD6TN UT WOS:000333394100012 PM 24642948 ER PT J AU Cummings, JF Guerrero, ML Moon, JE Waterman, P Nielsen, RK Jefferson, S Gross, FL Hancock, K Katz, JM Yusibov, V AF Cummings, James F. Guerrero, Melanie L. Moon, James E. Waterman, Paige Nielsen, Robin K. Jefferson, Stacie Gross, F. Liaini Hancock, Kathy Katz, Jacqueline M. Yusibov, Vidadi CA Fraunhofer USA Ctr Mol Biotechnolo TI Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults SO VACCINE LA English DT Article DE Influenza A; H1N1; Recombinant vaccine; Hemagglutinin; Plant-produced ID H5N1 VACCINE; CLINICAL-TRIAL; H1N1 VACCINE; PANDEMIC INFLUENZA; ALUMINUM-HYDROXIDE; RAPID PRODUCTION; IMMUNE-RESPONSE; AVIAN INFLUENZA; A/H5N1 VACCINE; ELDERLY ADULTS AB Background: Novel influenza viruses continue to pose a potential pandemic threat worldwide. In recent years, plants have been used to produce recombinant proteins, including subunit vaccines. A subunit influenza vaccine, HAC1, based on recombinant hemagglutinin from the 2009 pandemic A/California/04/2009 (HI NI) strain of influenza virus, has been manufactured using a plant virus-based transient expression technology in Nicotiana benthamiana plants and demonstrated to be immunogenic and safe in pre-clinical studies (Shoji et al., 2011). Methods: A first-in-human, Phase 1, single-center, randomized, placebo-controlled, single-blind, dose escalation study was conducted to investigate safety, reactogenicity and immunogenicity of an HAC1 formulation at three escalating dose levels (15 mu g, 45 mu g and 90 mu g) with and without Alhydrogel (R), in healthy adults 18-50 years of age (inclusive). Eighty participants were randomized into six study vaccine groups, a saline placebo group and an approved monovalent H1N1 vaccine group. Recipients received two doses of vaccine or placebo (except for the monovalent HI NI vaccine cohort, which received a single dose of vaccine, later followed by a dose of placebo). Results: The experimental vaccine was safe and well tolerated, and comparable to placebo and the approved monovalent HI NI vaccine. Pain and tenderness at the injection site were the only local solicited reactions reported following vaccinations. Nearly all adverse events were mild to moderate in severity. The HAC1 vaccine was also immunogenic, with the highest seroconversion rates, based on serum hemagglutination-inhibition and virus microneutralization antibody titers, in the 90 mu g non-adjuvanted HAC1 vaccine group after the second vaccine dose (78% and 100%, respectively). Conclusions: This is the first study demonstrating the safety and immunogenicity of a plant-produced subunit HI NI influenza vaccine in healthy adults. The results support further clinical investigation of the HAC1 vaccine as well as demonstrate the feasibility of the plant-based technology for vaccine antigen production. (C) 2014 Published by Elsevier Ltd. C1 [Cummings, James F.; Guerrero, Melanie L.; Moon, James E.; Waterman, Paige; Nielsen, Robin K.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Jefferson, Stacie; Gross, F. Liaini; Hancock, Kathy; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Yusibov, Vidadi] Fraunhofer USA Ctr Mol Biotechnol, Newark, DE 19711 USA. RP Cummings, JF (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM james.f.cummings6.mil@mail.mil RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 FU Defense Advanced Research Projects Agency (DARPA); DARPA [HR0011-10-C-0051] FX The HAC1 clinical trial and serologic testing were supported by the Defense Advanced Research Projects Agency (DARPA). The cGMP manufacture of HAC1 was supported by DARPA under contract number # HR0011-10-C-0051. NR 45 TC 21 Z9 23 U1 1 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD APR 17 PY 2014 VL 32 IS 19 BP 2251 EP 2259 DI 10.1016/j.vaccine.2013.10.017 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AG7XN UT WOS:000335632200017 PM 24126211 ER PT J AU McLeod, DSA Caturegli, P Cooper, DS Matos, PG Hutfless, S AF McLeod, Donald S. A. Caturegli, Patrizio Cooper, David S. Matos, Peter G. Hutfless, Susan TI Variation in Rates of Autoimmune Thyroid Disease by Race/Ethnicity in US Military Personnel SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID SURVEY NHANES-III; NATIONAL-HEALTH; PREVALENCE C1 [McLeod, Donald S. A.] QIMR Berghofer Med Res Inst, Dept Populat Hlth, Herston, Qld, Australia. [Caturegli, Patrizio] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Cooper, David S.] Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD USA. [Matos, Peter G.] US Army, Joint Munit Command Headquarters AMSJM HRS, Rock Isl, IL USA. [Hutfless, Susan] Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD USA. RP McLeod, DSA (reprint author), Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, QIMR Locked Bag 2000, Herston, Qld 4029, Australia. EM donald.mcleod@qimrberghofer.edu.au RI McLeod, Donald/C-4242-2014; OI McLeod, Donald/0000-0003-1131-020X; Hutfless, Susan/0000-0002-6311-2611 NR 6 TC 7 Z9 7 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 16 PY 2014 VL 311 IS 15 BP 1563 EP 1565 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AE9DX UT WOS:000334306000025 PM 24737370 ER PT J AU Ahn, SC Hubbard, B Cha, DK Kim, BJ AF Ahn, Se Chang Hubbard, Brian Cha, Daniel K. Kim, Byung J. TI Simultaneous removal of perchlorate and energetic compounds in munitions wastewater by zero-valent iron and perchlorate-respiring bacteria SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING LA English DT Article DE Munitions wastewater; zero-valent iron; perchlorate; RDX; perchlorate-respiring bacteria ID PACKED-BED BIOREACTOR; ELEMENTAL IRON; MICROBIAL REDUCTION; GAS-PHASE; AZO DYES; BIODEGRADATION; 2,4-DINITROTOLUENE; PRETREATMENT; DEGRADATION; NITRATE AB Ammonium perchlorate is one of the main constituents in Army's insensitive melt-pour explosive, PAX-21 in addition to RDX and 2,4-dinitroanisole (DNAN). The objective of this study is to develop an innovative treatment process to remove both perchlorate and energetic compounds simultaneously from PAX-21 production wastewater. It was hypothesized that the pretreatment of PAX-21 wastewater with zero-valent iron (ZVI) would convert energetic compounds to products that are more amenable for biological oxidation and that these products serve as electron donors for perchlorate-reducing bacteria. Results of batch ZVI reduction experiments showed that DNAN was completely reduced to 2,4-diaminoanisole and RDX was completely reduced to formaldehyde. Anaerobic batch biodegradation experiments showed that perchlorate (30mg L-1) in ZVI-treated PAX-21 wastewater was decreased to an undetectable level after 5days. Batch biodegradation experiments also confirmed that formaldehyde in ZVI-treated wastewater was the primary electron donor for perchlorate-respiring bacteria. The integrated iron-anaerobic bioreactor system was effective in completely removing energetic compounds and perchlorate from the PAX-21 wastewater without adding an exogenous electron donor. This study demonstrated that ZVI pretreatment not only removed energetic compounds, but also transformed energetic compounds to products that can serve as the source of electrons for perchlorate-respiring bacteria. C1 [Ahn, Se Chang; Hubbard, Brian; Cha, Daniel K.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Kim, Byung J.] US Army Engn Res & Dev Ctr, Champaign, IL USA. RP Cha, DK (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM cha@udel.edu NR 30 TC 3 Z9 3 U1 3 U2 59 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1093-4529 EI 1532-4117 J9 J ENVIRON SCI HEAL A JI J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng. PD APR 16 PY 2014 VL 49 IS 5 BP 575 EP 583 DI 10.1080/10934529.2014.859455 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 290SY UT WOS:000329779800009 PM 24410688 ER PT J AU Garcia-Reyero, N Kennedy, AJ Escalon, BL Habib, T Laird, JG Rawat, A Wiseman, S Hecker, M Denslow, N Steevens, JA Perkins, EJ AF Garcia-Reyero, Natalia Kennedy, Alan J. Escalon, B. Lynn Habib, Tanwir Laird, Jennifer G. Rawat, Arun Wiseman, Steven Hecker, Markus Denslow, Nancy Steevens, Jeffery A. Perkins, Edward J. TI Differential Effects and Potential Adverse Outcomes of Ionic Silver and Silver Nanoparticles in Vivo and in Vitro SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID P38 MAPK ACTIVATION; DAPHNIA-MAGNA; CONCEPTUAL-FRAMEWORK; TOXICITY; ZEBRAFISH; CELLS; FISH; RATS; NANOSILVER; RESPONSES AB Nanoparticles are of concern because of widespread use, but it is unclear if metal nanoparticles cause effects directly or indirectly. We explored whether polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs) cause effects through intact nanoparticles or dissolved silver. Females of the model species fathead minnow (Pimephales promelas) were exposed to either 4.8 mu g/L of AgNO3 or 61.4 mu g/L of PVP-AgNPs for 96h. Microarray analyses were used to identify impacted receptors and toxicity pathways in liver and brain tissues that were confirmed using in vitro mammalian assays. AgNO3 and PVP-AgNP exposed fish had common and distinct effects consistent with both intact nanoparticles and dissolved silver causing effects. PVP-AgNPs and AgNO3 both affected pathways involved in Na+, K+, and H+ homeostasis and oxidative stress but different neurotoxicity pathways. In vivo effects were supported by PVP-AgNP activation of five in vitro nuclear receptor assays and inhibition of ligand binding to the dopamine receptor. AgNO3 inhibited ligand binding to adrenergic receptors alpha 1 and alpha 2 and cannabinoid receptor CB1, but had no effect in nuclear receptor assays. PVP-AgNPs have the potential to cause effects both through intact nanoparticles and metal ions, each interacting with different initiating events. Since the in vitro and in vivo assays examined here are commonly used in human and ecological hazard screening, this work suggests that environmental health assessments should consider effects of intact nanoparticles in addition to dissolved metals. C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Kennedy, Alan J.; Escalon, B. Lynn; Laird, Jennifer G.; Steevens, Jeffery A.; Perkins, Edward J.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Rawat, Arun] TGen, Phoenix, AZ 85004 USA. [Wiseman, Steven; Hecker, Markus] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada. [Denslow, Nancy] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. [Denslow, Nancy] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA. RP Garcia-Reyero, N (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. EM nvinas@igbb.msstate.edu OI Wiseman, Steve/0000-0002-8215-2272 FU US Army Environmental Quality Research Program [BAA 11-4838] FX This work was funded by the US Army Environmental Quality Research Program (including BAA 11-4838 to N.G.R.). Permission was granted by the Chief of Engineers to publish this information. NR 58 TC 19 Z9 19 U1 3 U2 69 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2014 VL 48 IS 8 BP 4546 EP 4555 DI 10.1021/es4042258 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AF4CG UT WOS:000334658400037 PM 24684273 ER PT J AU Kane, SF Lynch, JH Taylor, JC AF Kane, Shawn F. Lynch, James H. Taylor, Jonathan C. TI Evaluation of Elbow Pain in Adults SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID OLECRANON BURSITIS; UPPER EXTREMITY; NERVE INJURIES; EPICONDYLITIS; MANAGEMENT; ENTRAPMENT; NEUROPATHIES; DIAGNOSIS; OVERUSE; ATHLETE AB The elbow is a complex joint designed to withstand a wide range of dynamic exertional forces. The location and quality of elbow pain can generally localize the injury to one of the four anatomic regions: anterior, medial, lateral, or posterior. The history should include questions about the onset of pain, what the patient was doing when the Pain started, and the type and frequency of athletic and occupational activities. Lateral and medial epicondylitis are two of the more common diagnoses and often occur as a result of occupational activities. Patients have pain and tenderness over the affected tendinous insertion that are accentuated with specific movements. If lateral and medial epicondylitis treatments are unsuccessful, ulnar neuropathy and radial tunnel syndrome should be considered. Ulnar collateral ligament injuries occur in athletes participating in sports that involve overhead throwing. Biceps tendinopathy is a relatively common source of pain in the anterior elbow; history often includes repeated elbow flexion with forearm supination and pronation. Olecranon bursitis is a common cause of posterior elbow pain and swelling. It can be septic or aseptic, and is diagnosed based on history, physical examination, and bursal fluid analysis if necessary. Plain radiography is the initial choice for the evaluation of acute injuries and is best for showing bony injuries, soft tissue swelling, and joint effusions. Magnetic resonance imaging is the preferred imaging modality for chronic elbow pain. Musculoskeletal ultrasonography allows for an inexpensive dynamic evaluation of commonly injured structures. Copyright (C) 2014 American Academy of Family Physicians. C1 [Kane, Shawn F.; Lynch, James H.; Taylor, Jonathan C.] Womack Army Med Ctr, Ft Bragg, NC USA. RP Kane, SF (reprint author), Attn AOMD, 2929 Desert Storm Dr Stop A, Ft Bragg, NC 28310 USA. EM shawn.f.kane.mil@mail.mil NR 39 TC 1 Z9 1 U1 2 U2 15 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 15 PY 2014 VL 89 IS 8 BP 649 EP + PG 14 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AF5CK UT WOS:000334731400005 PM 24784124 ER PT J AU Danielson, KT AF Danielson, Kent T. TI Fifteen node tetrahedral elements for explicit methods in nonlinear solid dynamics SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article DE Nonlinear solid dynamics; Second-order finite elements; Tetrahedron Explicit time integration; Mass matrix diagonalization; Mass lumping ID ASSUMED STRAIN STABILIZATION; COMPOSITE FINITE-ELEMENTS; QUADRATURE-FORMULAS; HOURGLASS CONTROL AB Despite the ease in meshing and benefits for modeling flexure, curved shapes, etc., secondorder tetrahedral elements are not contained in typical explicit solid dynamic programs. This is primarily due to the lack of both a satisfactory consistent nodal loading distribution and mass lumping technique. Row summation lumping, for instance, produces negative vertex node masses for the popular ten node "serendipity" tetrahedron, which also has zero vertex node loads resulting from a constant pressure on an element face. This has led to piecewise composites of four node tetrahedrons to represent a ten node one in explicit codes. In this paper, truly second-order fifteen node formulations for compressible and for nearly incompressible materials are presented and evaluated. In addition to producing all positive nodal loads from a uniform traction, row summation mass lumping for the fifteen node element is shown to produce all positive nodal masses. Performance is assessed in standard benchmark problems and practical applications using various elastic and elastic plastic material models and involving very large strains/deformations, severe distortions, and contact-impact. Comparisons are also made with several first-order elements and second-order hexahedral formulations. The offered elements performed satisfactorily in all examples. As recently found for second-order hexahedral elements, it is shown that the inclusion of face and centroidal nodes is vital for robust performance with row summation lumping, and high-order quadrature rules are crucial with explicit methods. These second-order elements are shown to be viable for practical applications, especially using today's parallel computers. Whereas the reliable performance is generally attained at significant computational expense compared with first-order and brick types, these elements can be more computationally competitive in flexure and have the desirable trait that they are amenable to automatic tetrahedral meshing software. Published by Elsevier B.V. C1 US Army Engineer Res & Dev Ctr, Res Grp, Engn Syst & Mat Div, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Danielson, KT (reprint author), US Army Engineer Res & Dev Ctr, Res Grp, Engn Syst & Mat Div, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Kent.T.Danielson@us.army.mil FU DoD High Performance Computing Modernization Program at the ERDC DoD Supercomputing Resource Center (DSRC); Geotechnical and Structures Laboratory FX Permission to publish was granted by Director, Geotechnical and Structures Laboratory. The work was supported in part by grants of computer time from the DoD High Performance Computing Modernization Program at the ERDC DoD Supercomputing Resource Center (DSRC). NR 59 TC 6 Z9 6 U1 1 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 EI 1879-2138 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD APR 15 PY 2014 VL 272 BP 160 EP 180 DI 10.1016/j.cma.2014.01.012 PG 21 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA AF1NR UT WOS:000334481100009 ER PT J AU Vindiola, MM Vettel, JM Gordon, SM Franaszczuk, PJ McDowell, K AF Vindiola, M. M. Vettel, J. M. Gordon, S. M. Franaszczuk, P. J. McDowell, K. TI Applying EEG phase synchronization measures to non-linearly coupled neural mass models SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Phase synchronization; Neural mass models; Phase locking value; Phase lag index; Imaginary coherence ID BRAIN ACTIVITY; FUNCTIONAL CONNECTIVITY; VISUAL-CORTEX; LAG INDEX; DYNAMICS; OSCILLATIONS; NETWORKS; RHYTHMS; MEG; ORGANIZATION AB Background: Recent neuroimaging analyses aim to understand how information is integrated across brain regions that have traditionally been studied in isolation; however, detecting functional connectivity networks in experimental EEG recordings is a non-trivial task. New method: We use neural mass models to simulate 10-s trials with coupling between 1-3 and 5-8 s and compare how well three phase-based connectivity measures recover this connectivity pattern across a set of experimentally relevant conditions: variable oscillation frequency and power spectrum, feed forward connections with or without feedback, and simulated signals with and without volume conduction. Results: Overall, the results highlight successful detection of the onset and offset of significant synchronizations for a majority of the 28 simulated configurations; however, the tested phase measures sometimes differ in their sensitivity and specificity to the underlying connectivity. Comparison with existing methods: Prior work has shown that these phase measures perform well on signals generated by a computational model of coupled oscillators. In this work we extend previous studies by exploring the performance of these measures on a different class of computational models, and we compare the methods on 28 variations that capture a set of experimentally relevant conditions. Conclusions: Our results underscore that no single phase synchronization measure is substantially better than all others, and experimental investigations will likely benefit from combining a set of measures together that are chosen based on both the experimental question of interest, the signal to noise ratio in the EEG data, and the approach used for statistical significance. Published by Elsevier B.V. C1 [Vindiola, M. M.] DRC High Performance Technol Grp, Reston, VA 20190 USA. [Vindiola, M. M.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Vettel, J. M.; Franaszczuk, P. J.; McDowell, K.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Gordon, S. M.] DCS Corp, Alexandria, VA 22310 USA. RP Vindiola, MM (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Bldg 120, Aberdeen Proving Ground, MD 21005 USA. EM mannyv@gmail.com RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU Army Research Laboratory; United States Department of Defense (DoD) High Performance Computing Modernization Program (HPCMP) User Productivity Enhancement and Technology Transfer and Training (PETIT) activities through Dynamics Research Corporation [GSO4TO9DBC0017] FX The authors would like to thank Peter Chung, Troy Lau, and Ruben Kraft for helpful discussions and directions with respect to the generation and analysis of simulation data. This research was sponsored by the Army Research Laboratory and was accomplished under under the United States Department of Defense (DoD) High Performance Computing Modernization Program (HPCMP) User Productivity Enhancement and Technology Transfer and Training (PETIT) activities through Dynamics Research Corporation under contract No. GSO4TO9DBC0017. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 50 TC 2 Z9 2 U1 1 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD APR 15 PY 2014 VL 226 BP 1 EP 14 DI 10.1016/j.jneumeth.2014.01.025 PG 14 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA AE4IR UT WOS:000333946600001 PM 24485868 ER PT J AU Li, QG O'Neil, M Xie, LS Caridha, D Zeng, Q Zhang, J Pybus, B Hickman, M Melendez, V AF Li, Qigui O'Neil, Michael Xie, Lisa Caridha, Diana Zeng, Qiang Zhang, Jing Pybus, Brandon Hickman, Mark Melendez, Victor TI Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections SO MALARIA JOURNAL LA English DT Article DE Prophylactic activity; Pharmacokinetic profile; Tafenoquine; Primaquine; Liver stage; Malaria infections; In vivo image system ID PLASMODIUM-FALCIPARUM MALARIA; FLOW-CYTOMETRIC MEASUREMENT; RODENT MALARIA; WR 238605; PNEUMOCYSTIS PNEUMONIA; VIVAX MALARIA; DOUBLE-BLIND; EFFICACY; ANTIMALARIAL; BERGHEI AB Background: As anti-malarial drug resistance escalates, new safe and effective medications are necessary to prevent and treat malaria infections. The US Army is developing tafenoquine (TQ), an analogue of primaquine (PQ), which is expected to be more effective in preventing malaria in deployed military personnel. Methods: To compare the prophylactic efficacy of TQ and PQ, a transgenic Plasmodium berghei parasite expressing the bioluminescent reporter protein luciferase was utilized to visualize and quantify parasite development in C57BL/6 albino mice treated with PQ and TQ in single or multiple regimens using a real-time in vivo imaging system (IVIS). As an additional endpoint, blood stage parasitaemia was monitored by flow cytometry. Comparative pharmacokinetic (PK) and liver distribution studies of oral and intravenous PQ and TQ were also performed. Results: Mice treated orally with three doses of TQ at 5 mg/kg three doses of PQ at 25 mg/kg demonstrated no bioluminescence liver signal and no blood stage parasitaemia was observed suggesting both drugs showed 100% causal activity at the doses tested. Single dose oral treatment with 5 mg TQ or 25 mg of PQ, however, yielded different results as only TQ treatment resulted in causal prophylaxis in P. berghei sporozoite-infected mice. TQ is highly effective for causal prophylaxis in mice at a minimal curative single oral dose of 5 mg/kg, which is a five-fold improvement in potency versus PQ. PK studies of the two drugs administered orally to mice showed that the absolute bioavailability of oral TQ was 3.5-fold higher than PQ, and the AUC of oral TQ was 94-fold higher than oral PQ. The elimination half-life of oral TQ in mice was 28 times longer than PQ, and the liver tissue distribution of TQ revealed an AUC that was 188-fold higher than PQ. Conclusions: The increased drug exposure levels and longer exposure time of oral TQ in the plasma and livers of mice highlight the lead quality attributes that explain the much improved efficacy of TQ when compared to PQ. C1 [Li, Qigui; O'Neil, Michael; Xie, Lisa; Caridha, Diana; Zeng, Qiang; Zhang, Jing; Pybus, Brandon; Hickman, Mark; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li.civ@mail.mil FU United States Army Research and Materiel Command FX This study was supported by the United States Army Research and Materiel Command. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author and are not to be construed as official, or as reflecting the views of the Department of the Army or the Department of Defense. NR 33 TC 12 Z9 12 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 14 PY 2014 VL 13 AR 141 DI 10.1186/1475-2875-13-141 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AF6FR UT WOS:000334810300001 PM 24731238 ER PT J AU Wang, CJ Pan, YL James, D Wetmore, AE Redding, B AF Wang, Chuji Pan, Yong-Le James, Deryck Wetmore, Alan E. Redding, Brandon TI Direct on-strip analysis of size- and time-resolved aerosol impactor samples using laser induced fluorescence spectra excited at 263 and 351 nm SO ANALYTICA CHIMICA ACTA LA English DT Article DE Atmospheric aerosol particles; Laser induced fluorescence spectra; Rotating drum impactor; Fluorescence cluster ID MASS-SPECTROMETRY; ATMOSPHERIC AEROSOL; ORGANIC AEROSOLS; SURFACE-ANALYSIS; ELECTROSPRAY-IONIZATION; PARTICLES; CLASSIFICATION; BIOAEROSOLS; CHEMISTRY; ABUNDANCE AB We report a novel atmospheric aerosol characterization technique, in which dual wavelength UV laser induced fluorescence (LIF) spectrometry marries an eight-stage rotating drum impactor (RDI), namely UV-LIF-RDI, to achieve size- and time-resolved analysis of aerosol particles on-strip. The UV-LIF-RDI technique measured LIF spectra via direct laser beam illumination onto the particles that were impacted on a RDI strip with a spatial resolution of 1.2 mm, equivalent to an averaged time resolution in the aerosol sampling of 3.6 h. Excited by a 263 nm or 351 nm laser, more than 2000 LIF spectra within a 3-week aerosol collection time period were obtained from the eight individual RDI strips that collected particles in eight different sizes ranging from 0.09 to 10 mu m in Djibouti. Based on the known fluorescence database from atmospheric aerosols in the US, the LIF spectra obtained from the Djibouti aerosol samples were found to be dominated by fluorescence clusters 2,5, and 8 (peaked at 330, 370, and 475 nm) when excited at 263 nm and by fluorescence clusters 1, 2, 5, and 6 (peaked at 390 and 460 nm) when excited at 351 nm. Size- and time-dependent variations of the fluorescence spectra revealed some size and time evolution behavior of organic and biological aerosols from the atmosphere in Djibouti. Moreover, this analytical technique could locate the possible sources and chemical compositions contributing to these fluorescence clusters. Advantages, limitations, and future developments of this new aerosol analysis technique are also discussed. Published by Elsevier B.V. C1 [Wang, Chuji; Pan, Yong-Le; James, Deryck; Wetmore, Alan E.] US Army Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA. [Redding, Brandon] Yale Univ, New Haven, CT 06510 USA. RP Pan, YL (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRA136477]; US Army Research Office [W911NF-13-1-0429, W911NF-13-1-0297]; US Army Research Laboratory (ARL) mission funds FX This research was supported by the Defense Threat Reduction Agency (DTRA) under contract number HDTRA136477, US Army Research Office grants W911NF-13-1-0429 and W911NF-13-1-0297, and US Army Research Laboratory (ARL) mission funds. NR 38 TC 2 Z9 2 U1 1 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 EI 1873-4324 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD APR 11 PY 2014 VL 820 BP 119 EP 132 DI 10.1016/j.aca.2014.02.037 PG 14 WC Chemistry, Analytical SC Chemistry GA AG7XG UT WOS:000335631500014 PM 24745745 ER PT J AU Akers, KS Mende, K Cheatle, KA Zera, WC Yu, X Beckius, ML Aggarwal, D Li, P Sanchez, CJ Wenke, JC Weintrob, AC Tribble, DR Murray, CK AF Akers, Kevin S. Mende, Katrin Cheatle, Kristelle A. Zera, Wendy C. Yu, Xin Beckius, Miriam L. Aggarwal, Deepak Li, Ping Sanchez, Carlos J. Wenke, Joseph C. Weintrob, Amy C. Tribble, David R. Murray, Clinton K. CA Infect Dis Clinical Res Program Tr TI Biofilms and persistent wound infections in United States military trauma patients: a case-control analysis SO BMC INFECTIOUS DISEASES LA English DT Article DE Biofilm; Risk factors; Trauma-related infections; Persistent infections; Chronic infections; Extremity wound infections ID IN-VITRO MODEL; OPERATION ENDURING FREEDOM; FIELD GEL-ELECTROPHORESIS; D-AMINO ACIDS; EXTREMITY INJURIES; ACINETOBACTER-CALCOACETICUS; ESCHERICHIA-COLI; OUTCOMES; IRAQ; WAR AB Background: Complex traumatic injuries sustained by military personnel, particularly when involving extremities, often result in infectious complications and substantial morbidity. One factor that may further impair patient recovery is the persistence of infections. Surface-attached microbial communities, known as biofilms, may play a role in hindering the management of infections; however, clinical data associating biofilm formation with persistent or chronic infections are lacking. Therefore, we evaluated the production of bacterial biofilms as a potential risk factor for persistent infections among wounded military personnel. Methods: Bacterial isolates and clinical data from military personnel with deployment-related injuries were collected through the Trauma Infectious Disease Outcomes Study. The study population consisted of patients with diagnosed skin and soft-tissue infections. Cases (wounds with bacterial isolates of the same organism collected 14 days apart) were compared to controls (wounds with non-recurrent bacterial isolates), which were matched by organism and infectious disease syndrome. Potential risk factors for persistent infections, including biofilm formation, were examined in a univariate analysis. Data are expressed as odds ratios (OR; 95% confidence interval [CI]). Results: On a per infected wound basis, 35 cases (representing 25 patients) and 69 controls (representing 60 patients) were identified. Eight patients with multiple wounds were utilized as both cases and controls. Overall, 235 bacterial isolates were tested for biofilm formation in the case-control analysis. Biofilm formation was significantly associated with infection persistence (OR: 29.49; CI: 6.24-infinity) in a univariate analysis. Multidrug resistance (OR: 5.62; CI: 1.02-56.92), packed red blood cell transfusion requirements within the first 24 hours (OR: 1.02; CI: 1.01-1.04), operating room visits prior to and on the date of infection diagnosis (OR: 2.05; CI: 1.09-4.28), anatomical location of infected wound (OR: 5.47; CI: 1.65-23.39), and occurrence of polymicrobial infections (OR: 69.71; CI: 15.39-infinity) were also significant risk factors for persistent infections. Conclusions: We found that biofilm production by clinical strains is significantly associated with the persistence of wound infections. However, the statistical power of the analysis was limited due to the small sample size, precluding a multivariate analysis. Further data are needed to confirm biofilm formation as a risk factor for persistent wound infections. C1 [Akers, Kevin S.; Sanchez, Carlos J.; Wenke, Joseph C.] JBSA Ft Sam, US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA. [Akers, Kevin S.; Mende, Katrin; Murray, Clinton K.] JBSA Ft Sam, Brooke Army Med Ctr, Dept Med Infect Dis Serv, Houston, TX USA. [Cheatle, Kristelle A.; Zera, Wendy C.; Yu, Xin; Aggarwal, Deepak; Li, Ping; Weintrob, Amy C.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Beckius, Miriam L.] JBSA Ft Sam, Brooke Army Med Ctr, Dept Clin Invest, Houston, TX USA. [Weintrob, Amy C.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Akers, KS (reprint author), JBSA Ft Sam, US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA. EM Kevin.s.akers.mil@mail.mil RI Chiang, Vincent, Ming-Hsien/D-4312-2016 OI Chiang, Vincent, Ming-Hsien/0000-0002-2029-7863 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program through the Uniformed Services University of the Health Sciences [IDCRP-024]; Department of Defense Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center, National Institute of Allergy and Infectious Diseases, National Institute of Health [Y1-AI-5072]; Department of the Navy under the Wounded, Ill, and Injured Program FX Part of this material was presented at 2013 ID Week: A Joint Meeting of IDSA, SHEA, HIVMA, and PIDs, October 2-6, 2013, San Francisco, CA. Support for this work (IDCRP-024) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded by the Department of Defense Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center, National Institute of Allergy and Infectious Diseases, National Institute of Health, under Inter-Agency Agreement Y1-AI-5072, and the Department of the Navy under the Wounded, Ill, and Injured Program. We are indebted to the Infectious Disease Clinical Research Program TIDOS study team of clinical coordinators, microbiology technicians, data managers, clinical site managers, and administrative support personnel for their tireless hours to ensure the success of this project. We would like to thank M. Leigh Carson for her assistance in the preparation of the manuscript. NR 58 TC 14 Z9 14 U1 0 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD APR 8 PY 2014 VL 14 AR 190 DI 10.1186/1471-2334-14-190 PG 11 WC Infectious Diseases SC Infectious Diseases GA AG5QB UT WOS:000335472500001 PM 24712544 ER PT J AU Goodwin, RA Politano, M Garvin, JW Nestler, JM Hay, D Anderson, JJ Weber, LJ Dimperio, E Smith, DL Timko, M AF Goodwin, R. Andrew Politano, Marcela Garvin, Justin W. Nestler, John M. Hay, Duncan Anderson, James J. Weber, Larry J. Dimperio, Eric Smith, David L. Timko, Mark TI Fish navigation of large dams emerges from their modulation of flow field experience SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE fish movement behavior; hydraulic pattern; individual-based model; fish passage; ecohydraulics ID COLUMBIA RIVER-BASIN; LATERAL-LINE; MOVEMENT ECOLOGY; PREY DETECTION; BROOK TROUT; BEHAVIOR; SALMON; ACCELERATION; TURBULENCE; MIGRATION AB Navigating obstacles is innate to fish in rivers, but fragmentation of the world's rivers by more than 50,000 large dams threatens many of the fish migrations these waterways support. One limitation to mitigating the impacts of dams on fish is that we have a poor understanding of why some fish enter routes engineered for their safe travel around the dam but others pass through more dangerous routes. To understand fish movement through hydropower dam environments, we combine a computational fluid dynamics model of the flow field at a dam and a behavioral model in which simulated fish adjust swim orientation and speed to modulate their experience to water acceleration and pressure (depth). We fit the model to data on the passage of juvenile Pacific salmonids (Oncorhynchus spp.) at seven dams in the Columbia/Snake River system. Our findings from reproducing observed fish movement and passage patterns across 47 flow field conditions sampled over 14 y emphasize the role of experience and perception in the decision making of animals that can inform opportunities and limitations in living resources management and engineering design. C1 [Goodwin, R. Andrew; Dimperio, Eric] US Army Engineer, Ctr Res & Dev, Environm Lab, Portland, OR 97208 USA. [Politano, Marcela; Weber, Larry J.] Univ Iowa, Dept Civil & Environm Engn, Iowa City, IA 52242 USA. [Garvin, Justin W.] Univ Iowa, Dept Mech & Ind Engn, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA. [Nestler, John M.; Smith, David L.] US Army Engineer, Ctr Res & Dev, Environm Lab, Vicksburg, MS 39180 USA. [Hay, Duncan] Oakwood Consulting Inc, Belcarra, BC V3H 4P3, Canada. [Anderson, James J.] Univ Washington, Sch Aquatic & Fishery Sci, Seattle, WA 98105 USA. [Timko, Mark] Blue Leaf Environm Inc, Ellensburg, WA 98926 USA. RP Goodwin, RA (reprint author), US Army Engineer, Ctr Res & Dev, Environm Lab, Portland, OR 97208 USA. EM andy.goodwin@us.army.mil FU Grant County Public Utility District; Chelan County Public Utility District; US Army Corps of Engineers FX We thank Yong G. Lai, Songheng Li, Raymond S. Chapman, Terry K. Gerald, and staff at IIHR-Hydroscience and Engineering; US Geological Survey (Columbia River Research Laboratory); Hydroacoustic Technology, Inc.; and Pacific Northwest National Laboratory. We also thank Pete Loucks, Desiree Tullos, Angela Saxe, Rich Fischer, Tammy Threadgill, Mike Langeslay, Lynn Reese, Laurie Ebner, Bertrand Lemasson, Chloe Bracis, Christina Caswell, Toni Toney, Dottie Tillman, and two anonymous referees for their constructive criticism and helpful comments, which substantially improved this manuscript. Tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under sponsorship of Grant County Public Utility District, Chelan County Public Utility District, and the US Army Corps of Engineers. NR 67 TC 9 Z9 9 U1 9 U2 58 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 8 PY 2014 VL 111 IS 14 BP 5277 EP 5282 DI 10.1073/pnas.1311874111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AE4VU UT WOS:000333985200057 PM 24706826 ER PT J AU Lee, JH Shubin, I Yao, J Bickford, J Luo, Y Lin, SY Djordjevic, SS Thacker, HD Cunningham, JE Raj, K Zheng, X Krishnamoorthy, AV AF Lee, Jin Hyoung Shubin, Ivan Yao, Jin Bickford, Justin Luo, Ying Lin, Shiyun Djordjevic, Stevan S. Thacker, Hiren D. Cunningham, John E. Raj, Kannan Zheng, Xuezhe Krishnamoorthy, Ashok V. TI High power and widely tunable Si hybrid external-cavity laser for power efficient Si photonics WDM links SO OPTICS EXPRESS LA English DT Article ID SILICON WAVE-GUIDE; PHOTODETECTOR; TECHNOLOGY; MODULATOR AB A highly efficient silicon (Si) hybrid external cavity laser with a wavelength tunable ring reflector is fabricated on a complementary metal-oxide semiconductor (CMOS)-compatible Si-on-insulator (SOI) platform and experimental results with high output power are demonstrated. A III-V semiconductor gain chip is edge-coupled into a SOI cavity chip through a SiNx spot size converter and Si grating couplers are incorporated to enable wafer-scale characterization. The laser output power reaches 20 mW and the highest wall-plug efficiency of 7.8% is measured at 17.3 mW in un-cooled condition. The laser wavelength tuning ranges are 8 nm for the single ring reflector cavity and 35 nm for the vernier ring reflector cavity, respectively. The Si hybrid laser is a promising light source for energy-efficient Si CMOS photonic links. (C) 2014 Optical Society of America C1 [Lee, Jin Hyoung; Shubin, Ivan; Yao, Jin; Luo, Ying; Lin, Shiyun; Djordjevic, Stevan S.; Thacker, Hiren D.; Cunningham, John E.; Raj, Kannan; Zheng, Xuezhe; Krishnamoorthy, Ashok V.] Oracle Syst, San Diego, CA 92121 USA. [Bickford, Justin] Army Res Lab, Adelphi, MD 20783 USA. RP Lee, JH (reprint author), Oracle Syst, 9515 Towne Ctr Dr, San Diego, CA 92121 USA. EM jin.hyoung.lee@oracle.com FU Defense Advanced Research Projects Agency (DARPA) [HR0011-08-09-0001] FX This material is based upon work supported, in part, by the Defense Advanced Research Projects Agency (DARPA) under Agreements HR0011-08-09-0001. The views expressed are those of the author and do not reflect the official policy or position of the Department of Defense or the U.S. Government. The authors thank Dr. Jag Shah of the DARPA Microsystems Technology Office (MTO) for his inspiration and support of this program. Approved for Public Release, Distribution Unlimited. NR 18 TC 31 Z9 31 U1 3 U2 31 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 7 PY 2014 VL 22 IS 7 BP 7678 EP 7685 DI 10.1364/OE.22.007678 PG 8 WC Optics SC Optics GA AH1RN UT WOS:000335898700032 PM 24718143 ER PT J AU Pan, YL Hill, SC Santarpia, JL Brinkley, K Sickler, T Coleman, M Williamson, C Gurton, K Felton, M Pinnick, RG Baker, N Eshbaugh, J Hahn, J Smith, E Alvarez, B Prugh, A Gardner, W AF Pan, Yong-Le Hill, Steven C. Santarpia, Joshua L. Brinkley, Kelly Sickler, Todd Coleman, Mark Williamson, Chatt Gurton, Kris Felton, Melvin Pinnick, Ronald G. Baker, Neal Eshbaugh, Jonathan Hahn, Jerry Smith, Emily Alvarez, Ben Prugh, Amber Gardner, Warren TI Spectrally-resolved fluorescence cross sections of aerosolized biological live agents and simulants using five excitation wavelengths in a BSL-3 laboratory SO OPTICS EXPRESS LA English DT Article ID LASER-INDUCED FLUORESCENCE; ULTRAVIOLET-LASER; BIOAEROSOLS; PARTICLES; SENSOR; SIZE; CLASSIFICATION; BIOMOLECULES; SPORES; FIELD AB A system for measuring spectrally-resolved fluorescence cross sections of single bioaerosol particles has been developed and employed in a biological safety level 3 (BSL-3) facility at Edgewood Chemical and Biological Center (ECBC). It is used to aerosolize the slurry or solution of live agents and surrogates into dried micron-size particles, and to measure the fluorescence spectra and sizes of the particles one at a time. Spectrally-resolved fluorescence cross sections were measured for (1) bacterial spores: Bacillus anthracis Ames (BaA), B. atrophaeus var. globigii (BG) (formerly known as Bacillus globigii), B. thuringiensis israelensis (Bti), B. thuringiensis kurstaki (Btk), B. anthracis Sterne (BaS); (2) vegetative bacteria: Escherichia coli (E. coli), Pantoea agglomerans (Eh) (formerly known as Erwinia herbicola), Yersinia rohdei (Yr), Yersinia pestis CO92 (Yp); and (3) virus preparations: Venezuelan equine encephalitis TC83 (VEE) and the bacteriophage MS2. The excitation wavelengths were 266 nm, 273 nm, 280 nm, 365 nm and 405 nm. (C) 2014 Optical Society of America C1 [Pan, Yong-Le; Hill, Steven C.; Coleman, Mark; Williamson, Chatt; Gurton, Kris; Felton, Melvin; Pinnick, Ronald G.] US Army, Res Lab, Adelphi, MD 20783 USA. [Santarpia, Joshua L.; Brinkley, Kelly; Baker, Neal; Eshbaugh, Jonathan; Hahn, Jerry; Smith, Emily; Alvarez, Ben] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Sickler, Todd; Prugh, Amber; Gardner, Warren] Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Pan, YL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil NR 40 TC 6 Z9 7 U1 1 U2 27 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 7 PY 2014 VL 22 IS 7 BP 8165 EP 8189 DI 10.1364/OE.22.008165 PG 25 WC Optics SC Optics GA AH1RN UT WOS:000335898700083 PM 24718194 ER PT J AU Benson, DC AF Benson, David C. TI Why the Internet Is Not Increasing Terrorism SO SECURITY STUDIES LA English DT Article AB Policymakers and scholars fear that the Internet has increased the ability of transnational terrorists, like al Qaeda, to attack targets in the West, even in the face of increased policing and military efforts. Although access to the Internet has increased across the globe, there has been no corresponding increase in completed transnational terrorist attacks. This analysis examines the causal logics-which have led to the conventional wisdom-and demonstrates both theoretically and empirically that the Internet is not a force multiplier for transnational terrorist organizations. Far from being at a disadvantage on the Internet, state security organs actually gain at least as much utility from the Internet as terrorist groups do, meaning that at worst the Internet leaves the state in the same position vis-a-vis terrorist campaigns as it was prior to the Internet. C1 [Benson, David C.] US Army, Washington, DC USA. [Benson, David C.] Univ Chicago, Program Int Polit Econ & Secur, Chicago, IL 60637 USA. [Benson, David C.] Univ Chicago, Program Int Secur Policy, Chicago, IL 60637 USA. [Benson, David C.] Univ Chicago, Project Secur & Terrorism, Chicago, IL 60637 USA. OI Benson, David/0000-0003-1961-0530 NR 95 TC 6 Z9 6 U1 3 U2 22 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0963-6412 EI 1556-1852 J9 SECUR STUD JI Secur. Stud. PD APR 3 PY 2014 VL 23 IS 2 BP 293 EP 328 DI 10.1080/09636412.2014.905353 PG 36 WC International Relations SC International Relations GA AH2HL UT WOS:000335942000003 ER PT J AU Kesavan, J Schepers, D Bottiger, J Edmonds, J AF Kesavan, Jana Schepers, Deborah Bottiger, Jerold Edmonds, Jason TI UV-C Decontamination of Aerosolized and Surface-Bound Single Spores and Bioclusters SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID ULTRAVIOLET GERMICIDAL IRRADIATION; UPPER-ROOM AIR; RADIATION; EFFICACY; MYCOBACTERIA; INACTIVATION; BACTERIA AB Biological particles are rarely individual organisms, but are clusters of organisms physically bound to one another, or bound to other material present in the environment. The size and composition of these bioclusters contribute to the protection of the organisms within the core of cluster from the harmful effects of ambient UV light. The use of ultraviolet irradiation has been evaluated in the past as an option for decontaminating surfaces and air; however, previous studies were conducted with single spores, or poorly characterized polydispersed aerosols making comparisons between studies difficult. This study is intended to evaluate the effect of UV-C irradiation on monodispersed particles of spore clusters with mean diameters of 2.8 mu m and 4.4 mu m, and single spores of Bacillus atrophaeus var. globigii on fixed surfaces and as aerosol. The D-90, the UV-C irradiation doses at which 90% of the colony forming units were rendered nonculturable, for single spores and spore clusters of 2.8 and 4.4 mu m on surfaces were 138, 725, and 1128 J/m(2), respectively. The respective values for airborne spores were 27, 42, and 86-94 J/m(2). The first-stage decay rate constant for the surface exposure ranged from 0.012 for single spores to 0.003 for 4.4 mu m clusters. Similarly, the aerosol decay rate constant ranged from 0.12 for single spores to 0.04 for 4.4 mu m clusters. The results of this study demonstrate that the decay rate of spores contained in clusters is proportional to the overall particle size, and that it is harder to inactivate large clusters on surfaces. Copyright 2014 American Association for Aerosol Research C1 [Kesavan, Jana; Edmonds, Jason] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Schepers, Deborah; Bottiger, Jerold] EXCET Inc, Springfield, VA USA. RP Kesavan, J (reprint author), US Army Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Jana.Kesavan@us.army.mil NR 24 TC 3 Z9 3 U1 1 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD APR 3 PY 2014 VL 48 IS 4 BP 450 EP 457 DI 10.1080/02786826.2014.889276 PG 8 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AB3LL UT WOS:000331692200012 ER PT J AU Kanchanapally, R Sinha, SS Fan, Z Dubey, M Zakar, E Ray, PC AF Kanchanapally, Rajashekhar Sinha, Sudarson Sekhar Fan, Zhen Dubey, Madan Zakar, Eugene Ray, Paresh Chandra TI Graphene Oxide-Gold Nanocage Hybrid Platform for Trace Level Identification of Nitro Explosives Using a Raman Fingerprint SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID METAL NANOPARTICLES; ANCHORING SEMICONDUCTOR; CANCER-CELL; SPECTROSCOPY; SCATTERING; ENHANCEMENT; TRINITROTOLUENE; REDUCTION; PROBE AB Trace level identification of explosive molecules are very important not only for security screening but also for the environment and human health. Driven by the need, the current article reports for the first time gold nanocage-graphene oxide hybrid platform for the spectral fingerprint and the trace level identification of RDX and TNT. Reported experimental data using RDX show that the surface-enhanced Raman spectroscopy (SERS) enhancement factor for graphene oxide (GO) attached gold nanocage assembly is 4 orders of magnitude higher than only nanocage, and it is due to the enormous field enhancement for the nanocage assembly. The current article demonstrates that label-free nitro-explosive identification limits using hybrid platform can be as low as 10 fM for TNT and 500 fM for RDX, which indicate that gold nanocage graphene oxide assembly can be very attractive for a variety of practical applications. C1 [Kanchanapally, Rajashekhar; Sinha, Sudarson Sekhar; Fan, Zhen; Ray, Paresh Chandra] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] US Army Res Lab, Adelphi, MD 20783 USA. RP Ray, PC (reprint author), Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. EM paresh.c.ray@jsums.edu RI fan, zhen/N-5244-2014; fan, zhen/M-8774-2014; OI fan, zhen/0000-0001-7937-8441; fan, zhen/0000-0001-7937-8441; Kanchanapally, Rajashekhar/0000-0002-9846-2611 FU NSF-PREM [DMR-1205194] FX Dr. Ray thanks NSF-PREM (grant DMR-1205194) for their generous funding. NR 45 TC 12 Z9 12 U1 5 U2 97 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 3 PY 2014 VL 118 IS 13 BP 7070 EP 7075 DI 10.1021/jp5015548 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AE8NM UT WOS:000334258600058 ER PT J AU Moores, G Shakarian, P Macdonald, B Howard, N AF Moores, Geoffrey Shakarian, Paulo Macdonald, Brian Howard, Nicholas TI Finding Near-Optimal Groups of Epidemic Spreaders in a Complex Network SO PLOS ONE LA English DT Article AB In this paper, we present algorithms to find near-optimal sets of epidemic spreaders in complex networks. We extend the notion of local-centrality, a centrality measure previously shown to correspond with a node's ability to spread an epidemic, to sets of nodes by introducing combinatorial local centrality. Though we prove that finding a set of nodes that maximizes this new measure is NP-hard, good approximations are available. We show that a strictly greedy approach obtains the best approximation ratio unless P = NP and then formulate a modified version of this approach that leverages qualities of the network to achieve a faster runtime while maintaining this theoretical guarantee. We perform an experimental evaluation on samples from several different network structures which demonstrate that our algorithm maximizes combinatorial local centrality and consistently chooses the most effective set of nodes to spread infection under the SIR model, relative to selecting the top nodes using many common centrality measures. We also demonstrate that the optimized algorithm we develop scales effectively. C1 [Moores, Geoffrey; Shakarian, Paulo] US Mil Acad, Elect Engn & Comp Sci Dept, West Point, NY 10996 USA. [Macdonald, Brian; Howard, Nicholas] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Moores, Geoffrey; Shakarian, Paulo; Macdonald, Brian; Howard, Nicholas] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. RP Shakarian, P (reprint author), US Mil Acad, Elect Engn & Comp Sci Dept, West Point, NY 10996 USA. EM paulo@shakarian.net FU Army Research Office FX This work is funded by the Army Research Office. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 25 TC 1 Z9 1 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 2 PY 2014 VL 9 IS 4 AR e90303 DI 10.1371/journal.pone.0090303 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AE6LC UT WOS:000334103000007 PM 24694693 ER PT J AU Castellani, JW Demes, R Endrusick, TL Cheuvront, SN Montain, SJ AF Castellani, John W. Demes, Robert Endrusick, Thomas L. Cheuvront, Samuel N. Montain, Scott J. TI Heat Removal Using Microclimate Foot Cooling: A Thermal Foot Manikin Study SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE heat strain; heat transfer; liquid cooling ID SKIN TEMPERATURE; EXERCISE; FEET AB Background: It has been proposed that microclimate cooling systems exploit the peripheral extremities because of more efficient heat transfer. The purpose of this study was to quantify, using a patented microclimate cooling technique, the heat transfer from the plantar surface of the foot for comparison to other commonly cooled body regions. Methods: A military boot was fitted with an insole embedded with a coiled, 1.27 m length of hollow tubing terminating in inlet and outlet valves. A thermal foot manikin with a surface temperature of 34 degrees C was placed in the boot and the valves were connected to a system that circulated water through the insole at a temperature of 20 degrees C and flow rate of 120 ml.min(-1). The manikin foot served as a constant heat source to determine heat transfer provided by the insole. Testing was done with the foot model dry and sweating at a rate of 500 ml.h(-1).m(-2). Climatic chamber conditions were 30 degrees C with 30% RH. Results: Heat loss was similar to 4.1 +/- 0.1 and similar to 7.7 +/- 0.3 W from the dry and sweating foot models, respectively. On a relative scale, the heat loss was 3.0 W and 5.5 W per 1% (unit) body surface area, respectively, for the dry and sweating conditions. Discussion:The relative heat loss afforded by plantar foot cooling was similar compared to other body regions, but the absolute amount of heat removal is unlikely to make an impact on whole body heat balance. C1 [Castellani, John W.; Demes, Robert; Endrusick, Thomas L.; Cheuvront, Samuel N.; Montain, Scott J.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Castellani, JW (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. EM john.castellani@us.army.mil NR 12 TC 0 Z9 0 U1 1 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 2014 VL 85 IS 4 BP 445 EP 448 DI 10.3357/ASEM.3781.2014 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA CB6FF UT WOS:000349721600008 PM 24754207 ER PT J AU Phillips, BN Eiseman, AS AF Phillips, Brandon N. Eiseman, Andrew S. TI Periorbital nodular fasciitis arising during pregnancy SO INDIAN JOURNAL OF OPHTHALMOLOGY LA English DT Article DE Nodular fasciitis; periorbital; pregnancy; sarcoma AB Nodular fasciitis (NF) is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was not located in the periorbital region. A weak presence of estrogen receptors has been reported in NF. This may make it more susceptible to the hormone-related changes during pregnancy and contribute to the development of the lesion by stimulating fibroblasts and smooth muscle cell types. Although rare, NF should be considered in the differential diagnosis of periorbital soft-tissue masses arising during pregnancy. C1 [Phillips, Brandon N.; Eiseman, Andrew S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. RP Phillips, BN (reprint author), Walter Reed Natl Mil Med Ctr, Ophthalmol Serv, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM brandon.n.phillips@us.army.mil NR 8 TC 1 Z9 1 U1 0 U2 1 PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 0301-4738 EI 1998-3689 J9 INDIAN J OPHTHALMOL JI Indian J. Ophthalmol. PD APR PY 2014 VL 62 IS 4 BP 520 EP 521 DI 10.4103/0301-4738.99862 PG 2 WC Ophthalmology SC Ophthalmology GA AZ9RI UT WOS:000348551300036 PM 23571242 ER PT J AU Austin, K Price, L McGraw, S Lieberman, H AF Austin, Krista Price, Lori McGraw, Susan Lieberman, Harris TI Longitudinal trends of dietary supplement use by US Army soldiers differ from the US civilian population SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Price, Lori] Tufts Med Ctr, Boston, MA USA. [Austin, Krista; McGraw, Susan; Lieberman, Harris] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 245.6 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646700273 ER PT J AU Effertz, C Johnson, B Convertino, V Joyner, M Curry, T AF Effertz, Cary Johnson, Blair Convertino, Victor Joyner, Michael Curry, Timothy TI Changes to erythrocyte markers during lower body negative pressure and graded blood loss in humans SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Effertz, Cary; Johnson, Blair; Joyner, Michael; Curry, Timothy] Mayo Clin, Rochester, MN USA. [Convertino, Victor] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 707.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646703362 ER PT J AU Gaffney-Stomberg, E Lutz, L Hughes, J Murphy, N Marchitelli, L Cable, S Young, A McClung, J AF Gaffney-Stomberg, Erin Lutz, Laura Hughes, Julie Murphy, Nancy Marchitelli, Louis Cable, Sonya Young, Andrew McClung, James TI A calcium and vitamin D fortified food product improves bone adaptation during military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Cable, Sonya] Initital Mil Training Ctr Excellence, Ft Eustis, VA USA. [Gaffney-Stomberg, Erin; Lutz, Laura; Hughes, Julie; Murphy, Nancy; Marchitelli, Louis; Young, Andrew; McClung, James] US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 634.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646702300 ER PT J AU Guerriere, K Beidleman, B Fulco, C Kenefick, R Staab, J Andrew, S Muza, S AF Guerriere, Katelyn Beidleman, Beth Fulco, Charles Kenefick, Robert Staab, Janet Andrew, Sean Muza, Stephen TI Cerebrovascular compliance is not associated with acute mountain sickness following staged ascent to 4300 m SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Guerriere, Katelyn; Beidleman, Beth; Fulco, Charles; Kenefick, Robert; Staab, Janet; Andrew, Sean; Muza, Stephen] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 708.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646703370 ER PT J AU Johnson, B van Helmond, N Curry, T Convertino, V Joyner, M AF Johnson, Blair van Helmond, Noud Curry, Timothy Convertino, Victor Joyner, Michael TI Catecholamine responses to central hypovolemia induced by lower body negative pressure and blood loss in humans SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Johnson, Blair; van Helmond, Noud; Curry, Timothy; Joyner, Michael] Mayo Clin, Rochester, MN USA. [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Convertino, Victor] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 707.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646703361 ER PT J AU Lin, G Murphy, N Gaffney-Stomberg, E Young, A McClung, J Pasiakos, S AF Lin, Gregory Murphy, Nancy Gaffney-Stomberg, Erin Young, Andrew McClung, James Pasiakos, Stefan TI High protein diets enhance glycemic regulation during energy restriction: a comparative analysis of milk- and soy-based diets SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Lin, Gregory; Murphy, Nancy; Gaffney-Stomberg, Erin; Young, Andrew; McClung, James; Pasiakos, Stefan] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 823.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646704498 ER PT J AU McClung, J Gaffney-Stomberg, E Lutz, L Rood, J Cable, S Pasiakos, S Young, A AF McClung, James Gaffney-Stomberg, Erin Lutz, Laura Rood, Jennifer Cable, Sonya Pasiakos, Stefan Young, Andrew TI Optimization of calcium and vitamin D status during initial military training: a randomized, double-blind, placebo-controlled trial SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Cable, Sonya] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA. [Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [McClung, James; Gaffney-Stomberg, Erin; Lutz, Laura; Pasiakos, Stefan; Young, Andrew] US Army, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 250.4 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646700299 ER PT J AU Pasiakos, S Murphy, N Margolis, L Gundersen, Y Martini, S Montain, S Young, A AF Pasiakos, Stefan Murphy, Nancy Margolis, Lee Gundersen, Yngvar Martini, Svein Montain, Scott Young, Andrew TI Effects of a 7-day military training exercise on whole-body protein turnover: an observation of military-specific protein requirements SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Gundersen, Yngvar; Martini, Svein] Norwegian Def Res Estab, Kjeller, Norway. [Pasiakos, Stefan; Murphy, Nancy; Margolis, Lee; Montain, Scott; Young, Andrew] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 820.9 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646704477 ER PT J AU Poh, P Carter, R Hinojosa-Laborde, C Mulligan, J Grudic, G Convertino, V AF Poh, Paula Carter, Robert, III Hinojosa-Laborde, Carmen Mulligan, Jane Grudic, Gregory Convertino, Victor TI Respiratory pump contributes to increased physiological reserve for compensation during reductions in central blood volume SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Mulligan, Jane; Grudic, Gregory] Flashback Technol Inc, Boulder, CO USA. [Poh, Paula] Univ Illinois, Urbana, IL USA. [Poh, Paula; Carter, Robert, III; Hinojosa-Laborde, Carmen; Convertino, Victor] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 707.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646703363 ER PT J AU Scrimgeour, A Carrigan, C Urso, M van Helden, H Joosen, M AF Scrimgeour, Angus Carrigan, Christopher Urso, Maria van Helden, Herman Joosen, Marloes TI Low dietary zinc promotes cell stress following blast injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [van Helden, Herman; Joosen, Marloes] TNO Earth Environm & Life Sci, Rijswijk, Netherlands. [Scrimgeour, Angus] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Carrigan, Christopher; Urso, Maria] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 122.5 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646700048 ER PT J AU Smith, T Montain, S Wilson, M Young, A AF Smith, Tracey Montain, Scott Wilson, Marques Young, Andrew TI A suction blister model reliably assesses skin barrier restoration and immune response SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 26-30, 2014 CL San Diego, CA SP Cenveo, LI COR, Wiley, Mead Johnson Pediat Nutr Inst, IPRECIO, F1000 Res, Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 [Smith, Tracey; Montain, Scott; Wilson, Marques; Young, Andrew] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 734.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0MP UT WOS:000346646704035 ER PT J AU Baer, L Wu, XW Wolf, S Wade, C AF Baer, Lisa Wu, Xioawu Wolf, Steven Wade, Charles TI High protein diet and insulin effects on catabolism in rats with burns and disuse SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Baer, Lisa; Wade, Charles] Univ Texas Hlth Sci Ctr Houston, CeTIR, Houston, TX 77030 USA. [Wolf, Steven] Univ Texas Southwestern, Dallas, TX USA. [Baer, Lisa; Wu, Xioawu; Wolf, Steven; Wade, Charles] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 1162.8 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002210 ER PT J AU Clarkson, E Smith, K Schulz, S Chandler, J Rousayne, C Kolanko, C AF Clarkson, Edward Smith, Kelly Schulz, Susan Chandler, Jessica Rousayne, Cassandra Kolanko, Christopher TI Pupillary light response in guinea pigs and swine exposed to organophosphate agents SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kolanko, Christopher] Eye Marker Syst Inc, Morgantown, WV USA. [Clarkson, Edward; Smith, Kelly; Schulz, Susan; Chandler, Jessica; Rousayne, Cassandra] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 1143.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002054 ER PT J AU Convertino, V Carter, R Hinojosa-Laborde, C AF Convertino, Victor Carter, Robert, III Hinojosa-Laborde, Carmen TI Variability in mechanisms associated with tolerance to progressive reductions in central blood volume SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Convertino, Victor; Carter, Robert, III; Hinojosa-Laborde, Carmen] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 1157.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002163 ER PT J AU Harvey, R Hart, E Charkoudian, N Curry, T Carter, J Fu, Q Minson, C Joyner, M Barnes, J AF Harvey, Ronee Hart, Emma Charkoudian, Nisha Curry, Timothy Carter, Jason Fu, Qi Minson, Christopher Joyner, Michael Barnes, Jill TI The relationship between muscle sympathetic nerve activity and hemodynamics in women taking oral contraceptive pills SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Harvey, Ronee; Curry, Timothy; Joyner, Michael; Barnes, Jill] Mayo Clin, Rochester, MN USA. [Carter, Jason] Michigan Technol Univ, Houghton, MI 49931 USA. [Charkoudian, Nisha] US Army Res Inst Environm Med, Natick, MA USA. [Hart, Emma] Univ Bristol, Bristol, Avon, England. [Minson, Christopher] Univ Oregon, Eugene, OR 97403 USA. [Fu, Qi] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 875.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651003112 ER PT J AU Hinojosa-Laborde, C Shade, R Bauer, C Muniz, G Pidcoke, H Goei, K Chung, K Cap, A Convertino, V AF Hinojosa-Laborde, Carmen Shade, Robert Bauer, Cassondra Muniz, Gary Pidcoke, Heather Goei, Kathleen Chung, Kevin Cap, Andrew Convertino, Victor TI Validation of lower body negative pressure as an experimental model of hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shade, Robert; Bauer, Cassondra] Texas Biomed Res Inst, San Antonio, TX USA. [Goei, Kathleen] Univ Incarnate Word, San Antonio, TX USA. [Hinojosa-Laborde, Carmen; Muniz, Gary; Pidcoke, Heather; Chung, Kevin; Cap, Andrew; Convertino, Victor] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 859.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002480 ER PT J AU Mozer, M Fadel, P Johnson, C Wallin, B Charkoudian, N Drobish, J Joyner, M Wehrwein, E AF Mozer, Michael Fadel, Paul Johnson, Christopher Wallin, B. Charkoudian, N. Drobish, Justin Joyner, Michael Wehrwein, Erica TI Acute slow-paced breathing increases periods of sympathetic nervous system quiescence SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mozer, Michael; Johnson, Christopher; Joyner, Michael] Mayo Clin, Rochester, MN USA. [Drobish, Justin; Wehrwein, Erica] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA. [Charkoudian, N.] US Army Res Inst Environm Med, Natick, MA USA. [Wallin, B.] Univ Gothenburg, Dept Clin Neurosci, Sahlgrenska Acad, Gothenburg, Sweden. [Fadel, Paul] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 1170.12 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002264 ER PT J AU Uyehara, C Rowland, M Sarkar, J Murata, LA Sato, A Ichimura, W Hernandez, C Kajiura, L AF Uyehara, Catherine Rowland, Michael Sarkar, Joy Murata, Lee-Ann Sato, Aileen Ichimura, Wayne Hernandez, Claudia Kajiura, Lauren TI Potassium exaggerates vasopressin response in Sus scrofa models of hemorrhagic shock but not endotoxic shock SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Uyehara, Catherine; Murata, Lee-Ann; Sato, Aileen; Ichimura, Wayne; Hernandez, Claudia; Kajiura, Lauren] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Rowland, Michael; Sarkar, Joy] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2014 VL 28 IS 1 SU S MA 859.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA AX0OG UT WOS:000346651002479 ER PT J AU Nguyen, LH Tran, T Do, T AF Nguyen, Lam H. Tran, Trac Do, Thong TI Sparse Models and Sparse Recovery for Ultra-Wideband SAR Applications SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID SYNTHETIC-APERTURE RADAR; ROBUST UNCERTAINTY PRINCIPLES; SIGNAL RECOVERY; INVERSE PROBLEMS; ERROR-CORRECTION; IMAGE-FORMATION; RECONSTRUCTION; REPRESENTATION; ALGORITHMS; PURSUIT AB This paper presents a simple yet very effective time-domain sparse representation and associated sparse recovery techniques that can robustly process raw data-intensive ultra-wideband (UWB) synthetic aperture radar (SAR) records in challenging noisy and bandwidth management environments. Unlike most previous approaches in compressed sensing for radar in general and SAR in particular, we take advantage of the sparsity of the scene and the correlation between the transmitted and received signal directly in the raw time domain even before attempting image formation. Our framework can be viewed as a collection of practical sparsity-driven preprocessing algorithms for radar applications that restores and denoises raw radar signals at each aperture position independently, leading to a significant reduction in the memory requirement as well as the computational complexity of the sparse recovery process. Recovery results from real-world data collected by the U. S. Army Research Laboratory (ARL) UWB SAR systems illustrate the robustness and effectiveness of our proposed framework on two critical applications: 1) recovery of missing spectral information in multiple frequency bands and 2) adaptive extraction and/or suppression of radio frequency interference (RFI) signals from SAR data records. C1 [Nguyen, Lam H.] US Army Res Lab, RF Signal Proc & Modelling, Adelphi, MD 20723 USA. [Tran, Trac] Johns Hopkins Univ, Baltimore, MD USA. [Do, Thong] MBO Partners Herndon, Herndon, VA USA. RP Nguyen, LH (reprint author), US Army Res Lab, RF Signal Proc & Modelling, 2800 Powder Mill Rd, Adelphi, MD 20723 USA. EM lam.h.nguyen2.civ@mail.mil NR 56 TC 4 Z9 5 U1 2 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD APR PY 2014 VL 50 IS 2 BP 940 EP 958 DI 10.1109/TAES.2014.120454 PG 19 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AS6HI UT WOS:000344364500012 ER PT J AU Costiner, S Winston, HA Ghoshal, A Welsh, GS Manes, EN Urban, MR Davis, M Bordick, NE AF Costiner, Sorin Winston, Howard A. Ghoshal, Anindya Welsh, Gregory S. Manes, Enrico N. Urban, Michael R. Davis, Mark Bordick, Nathaniel E. TI Asymmetric Acoustic Scattering for Structural Health Monitoring SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID DAMAGE DETECTION; COMPOSITE PLATES; LOCALIZATION; PROPAGATION; INTEGRITY; DIAGNOSIS; AIRCRAFT; SYSTEMS AB Methods for constructing damage localization maps from networks of piezoelectric lead zirconate titanate (PZT) acoustic sensor measurements were investigated. A new approach, asymmetric acoustic Scattering (AAS), for damage detection and localization using PZT sensor arrays was developed, and the conclusions were favorable compared to commercial software results. The AAS method is simple, computationally efficient, and general because it does not require geometric details of the component or complex physical models. The approach estimates damage in five stages: (1) damage index (DI) measures are computed for individual sensors, (2) DI-weighted averages are computed for pairs of sensors, (3) DI-weighted averages are used to generate local DI maps, (4) local DI maps are combined into frequency-dependent global DI maps, and (5) frequency-dependent DI maps are combined into global DI maps. The AAS algorithm generates temporal DI curves to increase the confidence of damage detection, whereas damage localization is accomplished with static distributed DI maps. Accuracy, robustness, and sensor array minimization methods for improving damage detection and localization were also investigated. C1 [Costiner, Sorin; Winston, Howard A.; Welsh, Gregory S.; Manes, Enrico N.] United Technol Res Ctr, E Hartford, CT 06108 USA. [Ghoshal, Anindya] US Army Res Lab, Prop Div, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Urban, Michael R.] Sikorsky Aircraft Corp, Struct Methods & Prognost, Stratford, CT USA. [Davis, Mark] Sikorsky Aircraft Corp, Adv Prognost & Hlth Management R&D, Stratford, CT USA. [Bordick, Nathaniel E.] Army Aviat Appl Technol Directorate, Ft Eustis, VA USA. RP Ghoshal, A (reprint author), US Army Res Lab, Prop Div, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil FU U.S. Government [W911W6-08-2-0013] FX This research was partially funded by the U.S. Government under Technology Investment Agreement No. W911W6-08-2-0013. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Aviation Applied Technology Directorate or the U.S. Government. NR 27 TC 1 Z9 1 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2014 VL 59 IS 2 AR 022005 DI 10.4050/JAHS.59.022005 PG 11 WC Engineering, Aerospace SC Engineering GA AS6HW UT WOS:000344365800005 ER PT J AU Sim, BW JanakiRam, RD Lau, BH AF Sim, Ben W. JanakiRam, Ram D. Lau, Benton H. TI Reduced In-Plane, Low-Frequency Noise of an Active Flap Rotor SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Results from a joint DARPA/Boeing/NASA/Army wind tunnel test demonstrated the ability to reduce in-plane, low-frequency noise of the full-scale Boeing-SMART(Smart Material Actuated Rotor Technology) rotor with active flaps. Test data reported in this paper illustrated that near-field acoustic energy in the first six blade-passing harmonics could be reduced by up to 6 dB at a moderate-airspeed, level flight condition at an advance ratio of 0.30. Reduced noise levels were attributed to selective active flap schedules that modified in-plane blade airloads on the advancing side of the rotor, generating counteracting acoustic pulses that partially offset the negative pressure peaks associated with in-plane, steady thickness noise. These favorable reduced-noise operating states are a strong function of the active flap actuation amplitude, frequency, and phase. The reduced noise levels resulted in reduction of predicted aural detection distance, but incurred vibratory load penalties due to increased hub shear forces. C1 [Sim, Ben W.] US Army Res Dev & Engn Command, AeroflightDynam Directorate, Moffett Field, CA 94035 USA. [JanakiRam, Ram D.] Boeing Co, Flight Technol, Mesa, AZ USA. [Lau, Benton H.] NASA, Aeromech Branch, Ames Res Ctr, Moffett Field, CA USA. RP Sim, BW (reprint author), US Army Res Dev & Engn Command, AeroflightDynam Directorate, Moffett Field, CA 94035 USA. EM ben.w.sim@us.army.mil NR 20 TC 2 Z9 2 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2014 VL 59 IS 2 AR 022002 DI 10.4050/JAHS.59.022002 PG 17 WC Engineering, Aerospace SC Engineering GA AS6HW UT WOS:000344365800002 ER PT J AU Lazarus, N Meyer, CD Bedair, SS AF Lazarus, Nathan Meyer, Christopher D. Bedair, Sarah S. TI Fractal Inductors SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article DE Fractals; inductor geometries; inductors; space filling curves; stretchable electronics ID THIN-FILM INDUCTORS AB This paper investigates the performance of planar inductors based on space filling curves, a family of fractals with the property of completely filling a bounded area. Fractal-based inductor design is a method for obtaining a very long trace lengths-and thus inductance densities-in 2-D space as a replacement for the serpentines currently used in one layer inductors. Because of the intricate course created by a fractal curve, these types of inductors are particularly well suited for stretchable electronics, where a tortuous path relieves mechanical stress and creates a more compliant structure. Inductors based on seven common space filling curves, all bounded within a one square millimeter area, were both simulated and measured experimentally and found to vary between 3.0 and 7.1 nH. Lower order fractals were found to give comparable performance to serpentine inductors with similar inductance density. More complicated fractals, after more than two iterations, were found to have lower inductance density than similar resistance serpentines. Mechanical simulations demonstrate a reduction in stress by a factor of 10 or more compared with the loop and serpentine designs. C1 [Lazarus, Nathan] US Army Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. [Meyer, Christopher D.; Bedair, Sarah S.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. EM nathan.lazarus2.ctr@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX This work was supported by the Army Research Laboratory under Cooperative Agreement W911NF-12-2-0019. NR 26 TC 3 Z9 3 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9464 EI 1941-0069 J9 IEEE T MAGN JI IEEE Trans. Magn. PD APR PY 2014 VL 50 IS 4 AR 8400708 DI 10.1109/TMAG.2013.2290510 PN 2 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA AQ7XJ UT WOS:000343033300023 ER PT J AU Gallus, JA Bunk, JA Matthews, RA Barnes-Farrell, JL Magley, VJ AF Gallus, Jessica A. Bunk, Jennifer A. Matthews, Russell A. Barnes-Farrell, Janet L. Magley, Vicki J. TI An Eye for an Eye? Exploring the Relationship Between Workplace Incivility Experiences and Perpetration SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY LA English DT Article DE incivility; incivility climate; incivility perpetration; organizational climate; gender ID COUNTERPRODUCTIVE WORK BEHAVIOR; SEXUAL-HARASSMENT; ABUSIVE SUPERVISION; SAFETY CLIMATE; AGGRESSION; ORGANIZATIONS; CONSEQUENCES; PERCEPTIONS; OUTCOMES; GENDER AB We examined the effects of gender and organizational climate for incivility on the relationship between individuals' incivility experiences and perpetration. Based on Andersson and Pearson's (1999) concept of the incivility spiral, Naylor, Pritchard, and Ilgen's (1980) theory of behavior in organizations, and social interactionist theory (Felson & Tedeschi, 1993), we proposed an interaction between incivility experiences, organizational climate for incivility (organizational tolerance and policies), and gender in predicting incivility perpetration. Results indicate that incivility experiences predict incivility perpetration and that men are more likely to be uncivil to others when their organization tolerates rudeness. Women's incivility experiences were associated with increased incivility perpetration, but were unaffected by incivility climate. Implications for research and practice are discussed. C1 [Gallus, Jessica A.] US Army Res Inst Behav & Social Sci, Fdn Sci Res Unit, Ft Belvoir, VA USA. [Bunk, Jennifer A.] West Chester Univ Pennsylvania, Dept Psychol, W Chester, PA USA. [Matthews, Russell A.] Bowling Green State Univ, Dept Psychol, Bowling Green, OH 43403 USA. [Barnes-Farrell, Janet L.; Magley, Vicki J.] Univ Connecticut, Dept Psychol, Storrs, CT USA. RP Gallus, JA (reprint author), 6000 6th St, Ft Belvoir, VA 22060 USA. EM jessica.gallus@gmail.com OI Matthews, Russell/0000-0003-3709-2757 NR 69 TC 11 Z9 12 U1 7 U2 24 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1076-8998 EI 1939-1307 J9 J OCCUP HEALTH PSYCH JI J. Occup. Health Psychol. PD APR PY 2014 VL 19 IS 2 BP 143 EP 154 DI 10.1037/a0035931 PG 12 WC Public, Environmental & Occupational Health; Psychology, Applied SC Public, Environmental & Occupational Health; Psychology GA AP6YP UT WOS:000342224900003 PM 24635736 ER PT J AU Stewart, IJ Fang, R Cannon, JW Zonies, DH Morrow, BD Orman, JA Oliver, JD Abbott, KC Jones, JA Chung, KK AF Stewart, Ian J. Fang, Raymond Cannon, Jeremy W. Zonies, David H. Morrow, Benjamin D. Orman, Jean A. Oliver, James D. Abbott, Kevin C. Jones, John A. Chung, Kevin K. TI Derivation of Candidates for the Combat Casualty Critical Care (C4) Database SO MILITARY MEDICINE LA English DT Article ID ACUTE KIDNEY INJURY; RESPIRATORY-DISTRESS-SYNDROME; MULTIPLE-ORGAN FAILURE; DAMAGE CONTROL RESUSCITATION; THEATER TRAUMA REGISTRY; RENAL-FAILURE; LUNG INJURY; TRANSFUSION; RISK; MORTALITY AB Objective: To describe the development of the Combat Casualty Critical Care Database, a comprehensive database of critically injured combat casualties to identify potentially modifiable risk factors for morbidity and mortality in this population. Methods: The Department of Defense's Joint Theater Trauma Registry was queried for all combat casualties injured from February 1, 2002 through February 1, 2011. The search was limited to patients who required admission to the intensive care unit and survived to be evacuated to Landstuhl Regional Medical Center. Results: The query yielded 6,011 patients. The mean age was 25.7 +/- 6.2 years. The majority of patients were male (98.3%), injured in Iraq (80%) and were members of the U. S. Army (72.6%). Most patients (58.0%) had an injury severity score in the lowest severity category (0-15). The mortality rate was 1.8%. The median day of death after injury (interquartile range) was 6 (3-14). Conclusions: We identified a cohort of critically wounded combat casualties that encompasses the majority of such patients injured in the course of the wars in Iraq and Afghanistan. When this database is fully populated, rigorous epidemiologic analysis will seek to identify factors associated with morbidity and mortality to improve future care. C1 [Stewart, Ian J.; Cannon, Jeremy W.; Morrow, Benjamin D.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Fang, Raymond] US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD 21201 USA. [Zonies, David H.] Landstuhl Reg Med Ctr, CMR 402, APO, AE 09180 USA. [Orman, Jean A.; Jones, John A.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Oliver, James D.; Abbott, Kevin C.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. OI Abbott, Kevin/0000-0003-2111-7112 FU U.S. Army of Surgical Research FX This project is supported by intramural funds from the U.S. Army of Surgical Research. NR 35 TC 4 Z9 4 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 370 EP 374 DI 10.7205/MILMED-D-13-00393 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300004 PM 24690960 ER PT J AU Dretsch, MN Johnston, D Bradley, RS MacRae, H Deuster, PA Harris, WS AF Dretsch, Michael N. Johnston, Daniel Bradley, Ryan S. MacRae, Holden Deuster, Patricia A. Harris, William S. TI Effects of Omega-3 Fatty Acid Supplementation on Neurocognitive Functioning and Mood in Deployed US Soldiers: A Pilot Study SO MILITARY MEDICINE LA English DT Article ID POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; FISH-OIL; DEPRESSION; COGNITION; SLEEP; DISORDERS; DESIGN; BRAIN; DHA AB Omega-3 fatty acids (FAs) may have neuroprotective properties for psychological health and cognition. The objective of this study was to evaluate the effectiveness of omega-3 FAs (eicosapentaenoic + docosahexaenoic; Harris-Schacky [HS]-Omega-3 Index) on neuropsychological functioning among U.S. Soldiers deployed to Iraq. This randomized, double-blind, placebo-controlled trial included Soldiers between the ages of 18 and 55 years who were randomly assigned to either the active treatment group (n = 44) or placebo group (n = 34). Active treatment was 2.5 g per day of eicosapentaenoic + docosahexaenoic (Lovaza; GlaxoSmithKline, Research Triangle Park, North Carolina). The placebo was corn oil ethyl esters. HS-Omega-3 Index, a neurocognitive battery (Central Nervous System-Vital Signs, Morrisville, North Carolina), and psychological health scales were assessed at baseline and after 60 days of treatment. Although the results revealed that omega-3 FAs significantly increased the HS-Omega-3 Index (p = 0.001), there were no significant effects on indices psychological health and neurocognitive functioning by treatment group. Nevertheless, there was a significant inverse correlation between the changes in the HS-Omega-3 Index and daytime sleepiness (r = 0.30, p = 0.009). Short-term treatment with 2.5 g of omega-3 FAs did not alter measures of neurocognition or psychological health, but there was evidence of a relationship between omega-3 levels and daytime sleepiness. C1 [Dretsch, Michael N.; Johnston, Daniel] Headquarters Dept,Army, Arlington, VA 22202 USA. [Dretsch, Michael N.] US Army, Aeromed Res Lab, Warfighter Hlth Div, Ft Rucker, AL 36362 USA. [Bradley, Ryan S.] WRNNMC, Bethesda, MD 20889 USA. [MacRae, Holden] Pepperdine Univ, Div Nat Sci, Malibu, CA 90263 USA. [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Harris, William S.] Univ S Dakota, Sanford Sch Med, Sioux Falls, SD 57105 USA. RP Dretsch, MN (reprint author), Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence NICoE, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 FU U.S. Army Aeromedical Research Laboratory, Fort Rucker, Alabama FX The authors thank the U.S. Army Aeromedical Research Laboratory for the shipping and use of neurocognitive testing platforms, the Consortium for Health and Military Performance Laboratory at the Uniformed Services University of the Health Sciences for assistance in coding, packaging, and shipping of product to Iraq, and OmegaQuant laboratories for processing all specimens. This work was supported in part by the U.S. Army Aeromedical Research Laboratory, Fort Rucker, Alabama. NR 42 TC 0 Z9 0 U1 7 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 396 EP 403 DI 10.7205/MILMED-D-13-00395 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300008 PM 24690964 ER PT J AU Teyhen, DS Riebel, MA McArthur, DR Savini, M Jones, MJ Goffar, SL Kiesel, KB Plisky, PJ AF Teyhen, Deydre S. Riebel, Mark A. McArthur, Derrick R. Savini, Matthew Jones, Mackenzie J. Goffar, Stephen L. Kiesel, Kyle B. Plisky, Phillip J. TI Normative Data and the Influence of Age and Gender on Power, Balance, Flexibility, and Functional Movement in Healthy Service Members SO MILITARY MEDICINE LA English DT Article ID CHRONIC ANKLE INSTABILITY; LOWER-EXTREMITY INJURY; INTERRATER RELIABILITY; HOP TESTS; MILITARY; SCREEN; PERFORMANCE; PREDICTORS; PREVENTION; DEFICITS AB Objectives: Determine the influence of age and sex and describe normative data on field expedient tests associated with power, balance, trunk stability, mobility, and functional movement in a military population.. Methods: Participants (n = 247) completed a series of clinical and functional tests, including closed-chain ankle dorsiflexion (DF), Functional Movement Screen (FMS), Y-Balance Test Lower Quarter (YBT-LQ), Y-Balance Test Upper Quarter (YBT-UQ), single leg vertical jump (SLVJ), 6-m timed hop (6-m timed), and triple hop. Descriptive statistics were calculated. Analysis of variance tests were performed to compare the results based on sex and age (<30years, >30years). Results: Service members demonstrated DF of 34.2 +/- 6.1 degrees, FMS composite score of 16.2 +/- 2.2, YBT-LQ normalized composite score of 96.9 +/- 8.6%, YBT-UQ normalized composite score of 87.6 +/- 9.6%, SLVJ of 26.9 +/- 8.6 cm, 6-m hop of 2.4 +/- 0.5 seconds, and a triple hop of 390.9 +/- 110.8 cm. Men performed greater than women (p < 0.05) on the YBT-LQ, YBT-UQ, SLVJ, 6-m timed, and triple hop. Those <30 years of age performed better than older participants (p < 0.05) on the DF, FMS, YBT-LQ, SLVJ, 6-m hop, and triple hop. Conclusions: Findings provide normative data on military members. Men performed better on power, balance, and trunk stability tests, whereas younger individuals performed better on power, balance, mobility, and functional movement. C1 [Teyhen, Deydre S.; Riebel, Mark A.; McArthur, Derrick R.; Savini, Matthew; Jones, Mackenzie J.; Goffar, Stephen L.] Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HMT, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, ATTN MCMR TT TATRC, Ft Detrick, MD 21702 USA. [Riebel, Mark A.] Naval Hosp, Dept Phys Therapy, North Camp Pendleton, CA 92055 USA. [McArthur, Derrick R.] Martin Army Community Hosp, Dept Phys Therapy, Ft Benning, GA 31905 USA. [Savini, Matthew] Gen Leonard Wood Army Community Hosp, Dept Phys Therapy, Ft Leonard Wood, MO 65473 USA. [Jones, Mackenzie J.] William Beaumont Army Med Ctr, Dept Phys Therapy, Ft Bliss, TX 79920 USA. [Kiesel, Kyle B.; Plisky, Phillip J.] Univ Evansville, Dept Phys Therapy, Evansville, IN 47722 USA. RP Teyhen, DS (reprint author), Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HMT, 3151 Scott Rd,Suite 1301, Ft Sam Houston, TX 78234 USA. FU U.S. Army Medical Research and Materiel Command (MRMC); Army Medical Department Advanced Medical Technology Initiative (AAMTI); Telemedicine and Advanced Technology Research Center (TATRC); Move2Perform; Dowling Group; Barcodes; Motorola Solutions FX This study was conducted in collaboration with research and administrative assistants from U.S. Army-Baylor University, Department of Physical Therapy, U.S. Army Medical Department Center and School, San Antonio, Texas, and Physical Therapy faculty from the University of Evansville and Duke University. Additional research assistance and support were provided by 1st LT Kelly Avant, 1st LT Joshua Chao, 1st LT George Clevenger, 1st LT Kathleen Glenesk, 1st LT Lindsay Nelson, 1st LT Cassie Saxion, 1st Lt Joshua Shumway, CPT Jon Umlauf, 1st LT Raymond Akerman, 1st LT John Canada, SFC Sean Stephens, SSG Christopher Villarreal, Lt Col Scott Shaffer, Lt Col Mike Walker, CPT Carrie Hoppes, Ms. Theresa Leatherwood, Mr. Paul Gorman, Dr. Ann-Mare Williams, Mr. Josh Miller, Mr. Jeff Wilson, Ms. Jennifer Prye and the cadre from the Basic Officer Leadership Course, Captain's Career Course, and the Physical Therapy Technician (N9) program. Support for this study was also provided by Dr. Robert Butler from Duke University. This research trial was supported by the U.S. Army Medical Research and Materiel Command (MRMC), Army Medical Department Advanced Medical Technology Initiative (AAMTI), Telemedicine and Advanced Technology Research Center (TATRC).; Drs. Kiesel and Plisky own equity in Move2Perform LLC and have developed the Move2Perform software that was used to collect data as part of this study. Dr. Plisky developed the Y-Balance Test that is also used in this study. Equipment and expertise for this study was supported by Move2Perform, The Dowling Group, Barcodes, and Motorola Solutions. NR 39 TC 10 Z9 10 U1 2 U2 16 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 413 EP 420 DI 10.7205/MILMED-D-13-00362 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300010 PM 24690966 ER PT J AU Li, RX McNeil, MM Pickering, S Pemberton, MR Duran, LL Collins, LC Nelson, MR Engler, RJM AF Li, Rongxia McNeil, Michael M. Pickering, Susanne Pemberton, Michael R. Duran, Laurie L. Collins, Limone C. Nelson, Michael R. Engler, Renata J. M. TI Military Healthcare Providers Reporting of Adverse Events Following Immunizations to the Vaccine Adverse Event Reporting System SO MILITARY MEDICINE LA English DT Article ID SAFETY AB Objectives: We studied military health care provider (HCP) practices regarding reporting of adverse events following immunization (AEFI). Methods: A convenience sample of HCP was surveyed to assess familiarity with Vaccine Adverse Event Reporting System (VAERS), AEFI they were likely to report, methods used and preferred for reporting, and perceived barriers to reporting. We analyzed factors associated with HCP reporting AEFI to VAERS. Results: A total of 547 surveys were distributed with 487 completed and returned for an 89% response rate. The percentage of HCP aware of VAERS (54%) varied by occupation. 47% of respondents identified knowledge of at least one AEFI with only 34% of these indicating that they had ever reported to VAERS. More serious events were more likely to be reported. Factors associated with HCP reporting AEFIs in bivariate analysis included HCP familiarity with filing a paper VAERS report, HCP familiarity with filing an electronic VAERS report, HCP familiarity with VAERS, and time spent on immunization tasks. In a multivariable analysis, only HCP familiarity with filing a paper VAERS report was statistically significant (Odds ratio = 115.3; p < 0.001). Conclusions: Specific educational interventions targeted to military HCP likely to see AEFIs but not currently filing VAERS reports may improve vaccine safety reporting practices. C1 [Li, Rongxia; McNeil, Michael M.; Pickering, Susanne] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA. [Pemberton, Michael R.] RTI Int, Res Triangle Pk, NC 27709 USA. [Duran, Laurie L.; Collins, Limone C.; Nelson, Michael R.; Engler, Renata J. M.] US Army Publ Hlth Command, Walter Reed Natl Mil Med Ctr, Healthcare Ctr Network, Mil Vaccine Agcy, Gaithersburg, MD 20899 USA. RP Li, RX (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, MS D-26,1600 Clifton Rd NE, Atlanta, GA 30333 USA. FU Centers for Disease Control and Prevention FX The authors thank the following individuals for their invaluable assistance with this study: Sandra L. Schneider, DrPH; Patricia A. Hutchinson, MD; John Grabenstein, PharmD, PhD; Mary C. Minor, FNP; Jeannette F. Williams, FNP; Sheila L. Hill, RN; Bryan L. Martin, DO; Christina Spooner, MS; Elaine Colen; and the supporting staff of the Vaccine Healthcare Centers Network (Walter Reed National Military Medical Center, Bethesda, MD; Womack Army Medical Center, Fort Bragg, NC; Wilford Hall Medical Center, San Antonio, TX; and Naval Medical Center Portsmouth, VA). The authors also thank RTI personnel for their assistance with the study and Frank DeStefano, MD MPH for critical review of the manuscript. The funding for this study was provided solely by the Centers for Disease Control and Prevention. NR 13 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 435 EP 441 DI 10.7205/MILMED-D-13-00391 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300013 PM 24690969 ER PT J AU Hire, JM Ramadorai, UE Contractor, D Jacobs, JM Bojescul, JA Abell, BE AF Hire, Justin M. Ramadorai, Uma E. Contractor, Dhruti Jacobs, Jeremy M. Bojescul, John A. Abell, Brian E. TI Intravenous Angiocatheters as a Novel Alternative to Semmes-Weinstein Monofilament Evaluation in Testing Protective Sensation SO MILITARY MEDICINE LA English DT Article ID DIABETIC FOOT ULCERATION; PERIPHERAL NEUROPATHY; HIGH-RISK; OUTCOMES AB Semmes-Weinstein monofilament (SWM) evaluation for protective sensation in diabetic feet is a widely used tool to guide patient care. Little evidence is available for alternative testing modalities for use when monofilament is not available or is deformed. Multiple varieties of intravenous angiocatheter tubing were subjected to biomechanical testing on a digital scale to assess the force generated once bending was observed by five independently tested raters. A 5.07 SWM (10 g) was tested in similar manner to establish a baseline and validate testing methodology. The 24 gauge x 0.75 in angiocatheter measured the closest to the 5.07 SWM (10 g) at an average force of 22 +/- 0.91 g compared with 10.2 +/- 0.13 g. Large-gauge angiocatheters measured greater forces. High intra-rater and inter-rater reliability was observed with all values greater than 0.98 (p < 0.001). A 24 gauge x 0.75 in angiocatheter tubing can be used as an alternative to the standard 5.07 SWM (10 g) for testing protective sensation in diabetic feet. Reviewing previously published receiver operating characteristics, this modality would yield estimated sensitivity and specificity values greater than 0.8 and 0.7, respectively, for detecting insensate feet tested at the bilateral metatarsal heads. C1 [Hire, Justin M.; Ramadorai, Uma E.; Contractor, Dhruti; Jacobs, Jeremy M.; Bojescul, John A.; Abell, Brian E.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA. RP Hire, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 Hosp Rd, Ft Gordon, GA 30905 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 442 EP 444 DI 10.7205/MILMED-D-13-00423 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300014 PM 24690970 ER PT J AU Washington, MA Agee, WA Kajiura, L Staege, CM Uyehara, CFT Barnhill, JC AF Washington, Michael A. Agee, Willie A., III Kajiura, Lauren Staege, Catherine M. Uyehara, Catherine F. T. Barnhill, Jason C. TI An Analysis of Staphylococcus aureus Infections at a Military Medical Center Using the PLEX-ID Combined Polymerase Chain Reaction-Mass Spectrometry System SO MILITARY MEDICINE LA English DT Article ID TOXIC-SHOCK-SYNDROME; METHICILLIN-RESISTANT; STRAINS; ORIGIN; USA300 AB Staphylococcus aureus (S. aureus) is a major cause of morbidity in the military health care setting. Culture-based methods are the most common means of identifying infections caused by this agent. However, culture-based methods lack sensitivity and specificity. The Abbott PLEX-ID instrument uses a combination of the polymerase chain reaction and mass spectrometry for the identification of bacterial isolates. We investigated whether the Abbott PLEX-ID system could identify S. aureus in clinical material and facilitate the epidemiological analysis of individual isolates. The PLEX-ID system positively identified 100% of isolates previously found to be methicillin resistant S. aureus by culture. In addition, analysis using the PLEX-ID software revealed that the majority of S. aureus isolates at Tripler Army Medical Center derive from clonal complex 8 and nearly 100% of these strains express the R-variant of the Panton-Valentine leukocidin virulence factor. These results demonstrate the utility of the PLEX-ID system in identifying clinical isolates and reveal an unexpected level of homogeneity among clinical S. aureus isolates recovered at Tripler Army Medical Center. These results also demonstrate the utility of the PLEX-ID system in identifying the resistance patterns, predicting the virulence properties, and tracking the migration of bacterial pathogens in the clinical setting. C1 [Washington, Michael A.; Kajiura, Lauren; Uyehara, Catherine F. T.; Barnhill, Jason C.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Agee, Willie A., III; Staege, Catherine M.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Washington, MA (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU Department of Clinical Investigation at Tripler Army Medical Center; Science Applications International Corporation (SAIC) FX The authors acknowledge the staff of the clinical microbiology laboratory at Tripler Army Medical Center and Abbott Biosciences for making this work possible. This work was funded by the Department of Clinical Investigation at Tripler Army Medical Center in association with the Science Applications International Corporation (SAIC). NR 21 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2014 VL 179 IS 4 BP 445 EP 450 DI 10.7205/MILMED-D-13-00472 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UK UT WOS:000340806300015 PM 24690971 ER PT J AU Irons, TP Martin, KE Finn, CA Bloss, BR Horton, RJ AF Irons, Trevor P. Martin, Kathryn E. Finn, Carol A. Bloss, Benjamin R. Horton, Robert J. TI Using Nuclear Magnetic Resonance and Transient Electromagnetics to characterise water distribution beneath an ice covered volcanic crater: the case of Sherman Crater Mt. Baker, Washington SO NEAR SURFACE GEOPHYSICS LA English DT Article; Proceedings Paper CT 5th Workshop on Magnetic Resonance Subsurface CT 5th Workshop Magnetic Resonance Subsurface CY SEP 25-27, 2012 CY SEP 25-27, 2012 CL Hannover, GERMANY CL Hannover, GERMANY ID DRIVEN GROUNDWATER-FLOW; MOUNT-RAINIER-VOLCANO; SURFACE NMR DATA; GEOMAGNETIC-FIELD; DEBRIS-FLOW; TEM DATA; RELAXATION; AQUIFERS; INVERSION; SLOPE AB Surface and laboratory Nuclear Magnetic Resonance (NMR) measurements combined with transient electromagnetic (TEM) data are powerful tools for subsurface water detection. Surface NMR (sNMR) and TEM soundings, laboratory NMR, complex resistivity, and X-Ray Diffraction (XRD) analysis were all conducted to characterise the distribution of water within Sherman Crater on Mt. Baker, WA. Clay rich rocks, particularly if water saturated, can weaken volcanoes, thereby increasing the potential for catastrophic sector collapses that can lead to far-travelled, destructive debris flows. Detecting the presence and volume of shallow groundwater is critical for evaluating these landslide hazards. The TEM data identified a low resistivity layer (<10 ohm-m), under 60 m of glacial ice related to water saturated clays. The TEM struggles to resolve the presence or absence of a plausible thin layer of bulk liquid water on top of the clay. The sNMR measurements did not produce any observable signal, indicating the lack of substantial accumulated bulk water below the ice. Laboratory analysis on a sample from the crater wall that likely represented the clays beneath the ice confirmed that the controlling factor for the lack of sNMR signal was the fine-grained nature of the media. The laboratory measurements further indicated that small pores in clays detected by the XRD contain as much as 50% water, establishing an upper bound on the water content in the clay layer. Forward modelling of geologic scenarios revealed that bulk water layers as thin as m between the ice and clay layer would have been detectable using sNMR. The instrumentation conditions which would allow for sNMR detection of the clay layer are investigated. Using current instrumentation the combined analysis of the TEM and sNMR data allow for valuable characterisation of the groundwater system in the crater. The sNMR is able to reduce the uncertainty of the TEM in regards to the presence of a bulk water layer, a valuable piece of information in hazard assessment. C1 [Irons, Trevor P.; Martin, Kathryn E.] Colorado Sch Mines, Ctr Grav Elect & Magnet Studies, Golden, CO 80401 USA. [Irons, Trevor P.; Finn, Carol A.; Bloss, Benjamin R.; Horton, Robert J.] US Geol Survey, Crustal Geophys & Geochem Sci Ctr, Denver Fed Ctr, Lakewood, CO 80225 USA. [Martin, Kathryn E.] US Army Corps Engineers, Engineers Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Irons, TP (reprint author), XRI Geophys, 6207 Highway 80 East, Vicksburg, MS 39180 USA. EM Trevor.Irons@xrigeo.com NR 74 TC 1 Z9 1 U1 0 U2 14 PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS PI 3990 DB, HOUTEN PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS SN 1569-4445 EI 1873-0604 J9 NEAR SURF GEOPHYS JI Near Surf. Geophys. PD APR PY 2014 VL 12 IS 2 BP 285 EP 296 DI 10.3997/1873-0604.2014009 PG 12 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AM1QU UT WOS:000339623700010 ER PT J AU Irons, T Quinn, MC Li, YG McKenna, JR AF Irons, Trevor Quinn, Meghan C. Li, Yaoguo McKenna, Jason R. TI A numerical assessment of the use of surface nuclear magnetic resonance to monitor internal erosion and piping in earthen embankments SO NEAR SURFACE GEOPHYSICS LA English DT Article; Proceedings Paper CT 5th Workshop on Magnetic Resonance Subsurface CT 5th Workshop Magnetic Resonance Subsurface CY SEP 25-27, 2012 CY SEP 25-27, 2012 CL Hannover, GERMANY CL Hannover, GERMANY ID NMR; AQUIFER; TIME AB The ability to non-invasively detect and monitor internal erosion and piping in earthen embankments is of great value to government agencies and municipalities responsible for maintaining large numbers of civil structures. Internal erosion can be a difficult failure mode of dams and levees to assess using traditional techniques. Surface nuclear magnetic resonance is a promising technology for monitoring these structures due to its direct sensitivity to liquid water. This is a new application for the method, and requires the formulation of a robust modelling framework capable of incorporating three dimensional water content models and topography. Adaptive octree meshes represent an efficient means to perform these calculations, as they are able to adapt and refine in areas where the kernel function is changing rapidly. Given the non-trivial challenges associated with the development of realistic water content models, we focus on first-order effects and present six 2.5D flow models representing seepage through a loaded earthen embankment under varying levels of erosional piping. Simulation results show that the employment of multiple surface nuclear magnetic resonance transmitter and receiver loops can provide early detection and effective monitoring of piping under the assumption of a 2.5D water content model. Therefore, the surface nuclear magnetic resonance technique has promise as a means for detection and/or monitoring of internal erosion and piping in earthen embankments. C1 [Irons, Trevor] Colorado Sch Mines, Ctr Grav Elect & Magnet Studies, Golden, CO 80401 USA. [Quinn, Meghan C.] US Army Corps Engineers, New England Dist, Concord, MA 01742 USA. [Li, Yaoguo] Colorado Sch Mines, Dept Geophys, Ctr Grav Elect & Magnet Studies, Golden, CO 80401 USA. [McKenna, Jason R.] 4QTRS Holdings LLC, Vicksburg, MS 39180 USA. RP Irons, T (reprint author), XRI Geophys, 14828 3B W 6th Ave, Golden, CO 80401 USA. EM Trevor.Irons@xrigeo.com FU US Army Corps Engineer Research and Development Center FX The authors gratefully acknowledge funding from the US Army Corps Engineer Research and Development Center. We also thank Joseph Capriotti for his assistance in converting Seep/W results files into VTK format. NR 27 TC 2 Z9 2 U1 1 U2 9 PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS PI 3990 DB, HOUTEN PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS SN 1569-4445 EI 1873-0604 J9 NEAR SURF GEOPHYS JI Near Surf. Geophys. PD APR PY 2014 VL 12 IS 2 BP 325 EP 334 DI 10.3997/1873-0604.2014004 PG 10 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AM1QU UT WOS:000339623700013 ER PT J AU Hariharan, S Bisdikian, C Kaplan, LM Pham, T AF Hariharan, Srikanth Bisdikian, Chatschik Kaplan, Lance M. Pham, Tien TI Efficient Solutions Framework for Optimal Multitask Resource Assignments for Data Fusion in Wireless Sensor Networks SO ACM TRANSACTIONS ON SENSOR NETWORKS LA English DT Article DE Design; Algorithms; Performance; Wireless sensor networks; data fusion; resource assignment; multitarget tracking ID WEIGHT INDEPENDENT SET; LAGRANGIAN-RELAXATION; SELECTION; ALLOCATION; TRACKING AB Motivated by the need to judiciously allocate scarce sensing resources to attain the highest benefit for the applications that sensor networks serve, in this article we develop a flexible solutions methodology for maximizing the overall reward attained, subject to constraints on the resource demands under fairly general reward or demand functions. We map a broad class of related problems for data fusion in wireless sensor networks into an integer programming problem and provide an iterative Lagrangian relaxation technique to solve it. Each iteration step involves solving for a maximum-weight independent set of an appropriately constructed graph, which, in many cases, can be obtained in polynomial time. We apply our methodology to the problem of tracking targets moving over a period of time through a nonhomogeneous, energy-constrained sensor field. With rewards represented by the quality of information attained in tracking, we study its trade-offs and relationship with energy consumption and periodic measurement taking. We finally illustrate other applications of our framework in sensor networks. C1 [Hariharan, Srikanth] AT&T Labs, Austin, TX 78759 USA. [Bisdikian, Chatschik] IBM TJ Watson Res, Yorktown Hts, NY 10598 USA. [Kaplan, Lance M.; Pham, Tien] Army Res Lab, Adelphi, MD USA. RP Hariharan, S (reprint author), AT&T Labs, Austin, TX 78759 USA. EM srikanth.hariharan@gmail.com FU U.S. Army Research Laboratory [W911NF-06-3-0002-P00013]; ARO MURI [W911NF-07-10376] FX This research was sponsored by U.S. Army Research Laboratory and was accomplished under agreement no. W911NF-06-3-0002-P00013, and ARO MURI award no. W911NF-07-10376. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory, or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 28 TC 2 Z9 2 U1 0 U2 7 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1550-4859 EI 1550-4867 J9 ACM T SENSOR NETWORK JI ACM Trans. Sens. Netw. PD APR PY 2014 VL 10 IS 3 AR 48 DI 10.1145/2594768 PG 26 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AJ6KV UT WOS:000337804100011 ER PT J AU Sanchez, LM Grobicki, AD Smith, GL Pulskamp, JS Takeuchi, I Polcawich, RG AF Sanchez, Luz M. Grobicki, Alden D. Smith, Gabriel L. Pulskamp, Jeffrey S. Takeuchi, Ichiro Polcawich, Ronald G. TI Texture Control in Lead Zirconate Titanate Multilayer Thin Films SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID MEMS APPLICATIONS; TECHNOLOGIES; ACTUATOR AB Multilayer actuators (MLAs) offer an increase of force per unit area, a reduction in power consumption, and a reduction in required driving voltages compared with single-layer actuators. For example, switching from a single 0.5- or 1.0-mu m layer of PZT to multiple 250-nm-thick layers would enable a 2/3 to 3/4 reduction in actuation voltage and an increase of 2 to 3 times in actuation force per area for a PZT MEMS switches and robotics. Efforts have been focused on developing actuators using four 250-nm-thick layers of PZT with a Zr/Ti ratio of 52/48 (i.e., the morphotropic phase boundary). The PZT films used a previously established method of achieving greater than 98% (001/100) oriented PZT by chemical solution deposition (CSD). By performing X-ray diffraction measurements between each layer, the texture within the films could be monitored during the growth process. To electrically measure the quality of the PZT multilayer stack, a series of six-sided capacitors were fabricated. The devices were connected in parallel with an average dielectric constant of 1150 for each PZT layer and an average total capacitance of 45 nF. In addition to capacitors, cantilever actuators were fabricated to measure the piezoelectric induced deformation. Comparisons with 100-mu m-long cantilever between a single 1-mu m-thick PZT and four 250-nm-thick layer PZT stack have shown comparable displacements of vertical bar 3.7 vertical bar mu m and vertical bar 4.0 vertical bar mu m, respectively, with an applied electric field of 10 V/mu m across the film. These measurements on MLA PZT films demonstrate high piezoelectric coefficients that are suitable for tactile radio and milimeter-scale robotic devices. C1 [Sanchez, Luz M.; Grobicki, Alden D.; Smith, Gabriel L.; Pulskamp, Jeffrey S.; Polcawich, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA. [Sanchez, Luz M.; Grobicki, Alden D.; Takeuchi, Ichiro] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Pulskamp, Jeffrey S.; Polcawich, Ronald G.] US Army Res Lab, Micro & Nano Mat & Devices Branch, Adelphi, MD USA. RP Sanchez, LM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM Luz.M.Sanchez16.civ@mail.mil NR 21 TC 3 Z9 3 U1 2 U2 26 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 EI 1525-8955 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD APR PY 2014 VL 61 IS 4 BP 654 EP 661 DI 10.1109/TUFFC.2014.2953 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA AI8AW UT WOS:000337126100010 ER PT J AU Tofsted, DH AF Tofsted, David H. TI Extended high-angular-frequency analysis of turbulence effects on short-exposure imaging SO OPTICAL ENGINEERING LA English DT Article DE atmospheric optics; atmospheric turbulence; image formation theory; modulation transfer function ID MODULATION TRANSFER-FUNCTION; ATMOSPHERIC-TURBULENCE; DISTORTION; PROPAGATION; STATISTICS; RESOLUTION; IMAGES AB An improved analysis of optical turbulence effects on short-exposure passive (SE) imaging is described, resulting in a new analytic expression for the SE modulation transfer function (MTF). This analysis expands on a 2011 study that examined characteristics of a tilt-phase component discovered in the standard theory of SE turbulence effects characterization. The analysis introduces an improved integration technique and a reformulated phase structure function, facilitating computation of a 38,007 element database of MTF results at low-to high-angular frequencies covering a wide range of diffraction and turbulence conditions. Analysis of this database is described, yielding a new analytic SE MTF, accurate to a root-mean-square error of 0.000218 versus the database. Comparisons show that the new expression is well correlated to an alternative computationally intensive method, and it is a factor 29 to 64 improvement over prior analytic expressions. Limits of applicability of the approach for incoherent imaging are also discussed. The low-computational cost of the new method is suitable for systems performance modeling of turbulence impacts, including path-varying turbulence scenarios. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 US Army Res Lab, Computat & Informat Sci Directorate, Attn RDRL CIE D, White Sands Missile Range, NM 88002 USA. RP Tofsted, DH (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Attn RDRL CIE D, White Sands Missile Range, NM 88002 USA. EM david.h.tofsted.civ@mail.mil NR 37 TC 3 Z9 4 U1 0 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD APR PY 2014 VL 53 IS 4 AR 044112 DI 10.1117/1.OE.53.4.044112 PG 10 WC Optics SC Optics GA AI2AW UT WOS:000336659700024 ER PT J AU Singamaneni, SR Stesmans, A van Tol, J Kosynkin, DV Tour, JM AF Singamaneni, Srinivasa Rao Stesmans, Andre van Tol, Johan Kosynkin, D. V. Tour, James M. TI Magnetic defects in chemically converted graphene nanoribbons: electron spin resonance investigation SO AIP ADVANCES LA English DT Article ID CARBON NANOTUBES; TRANSPORT; RELAXATION; FUNCTIONALIZATION; ADSORPTION; NITROGEN; ESR AB Electronic spin transport properties of graphene nanoribbons (GNRs) are influenced by the presence of adatoms, adsorbates and edge functionalization. To improve the understanding of the factors that influence the spin properties of GNRs, local (element) spin-sensitive techniques such as electron spin resonance (ESR) spectroscopy are important for spintronics applications. Here, we present results of multi-frequency continuous wave (CW), pulse and hyperfine sublevel correlation (HYSCORE) ESR spectroscopy measurements performed on oxidatively unzipped graphene nanoribbons (GNRs), which were subsequently chemically converted (CCGNRs) with hydrazine. ESR spectra at 336 GHz reveal an isotropic ESR signal from the CCGNRs, of which the temperature dependence of its line width indicates the presence of localized unpaired electronic states. Upon functionalization of CCGNRs with 4-nitrobenzene diazonium tetrafluoroborate, the ESR signal is found to be 2 times narrower than that of pristine ribbons. NH3 adsorption/desorption on CCGNRs is shown to narrow the signal, while retaining the signal intensity and g value. The electron spin-spin relaxation process at 10 K is found to be characterized by slow (163 ns) and fast (39 ns) components. HYSCORE ESR data demonstrate the explicit presence of protons and C-13 atoms. With the provided identification of intrinsic point magnetic defects such as proton and C-13 has been reported, which are roadblocks to spin travel in graphene-based materials, this work could help in advancing the present fundamental understanding on the edge-spin (or magnetic)-based transport properties of CCGNRs. (C) 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License. C1 [Singamaneni, Srinivasa Rao; Stesmans, Andre] Katholieke Univ Leuven, INPAC Inst Nanoscale Phys & Chem, Semicond Phys Lab, B-3001 Louvain, Belgium. [Singamaneni, Srinivasa Rao] Army Res Off, Mat Sci Div, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [van Tol, Johan] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Kosynkin, D. V.; Tour, James M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Dept Chem, Houston, TX 77005 USA. [Tour, James M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Tour, James M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Houston, TX 77005 USA. RP Singamaneni, SR (reprint author), Katholieke Univ Leuven, INPAC Inst Nanoscale Phys & Chem, Semicond Phys Lab, Celestijnenlaan 200D, B-3001 Louvain, Belgium. EM ssingam@ncsu.edu RI van Tol, Johan/G-4190-2011; OI van Tol, Johan/0000-0001-6972-2149; Tour, James/0000-0002-8479-9328 FU National Academy of Science (NAS), USA; NSF [DMR-0654118]; State of Florida; Air Force Office of Scientific Research [FA9550-09-1-0581]; Office of Naval Research MURI Graphene program FX SSR acknowledges National Academy of Science (NAS), USA for awarding the NRC post-doctoral research associate fellowship. The National High Magnetic Field Laboratory is supported by NSF Cooperative Agreement No. DMR-0654118, and by the State of Florida. The work at Rice University was supported by the Air Force Office of Scientific Research FA9550-09-1-0581 and the Office of Naval Research MURI Graphene program. NR 42 TC 3 Z9 3 U1 5 U2 38 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 2158-3226 J9 AIP ADV JI AIP Adv. PD APR PY 2014 VL 4 IS 4 AR 047104 DI 10.1063/1.4870942 PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA AH4FG UT WOS:000336082000021 ER PT J AU Witzel, J AF Witzel, John TI Simple DC motors SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material DE Magnetic domains; Wires; Batteries; Magnetomechanical effects; DC motors; Coils; Nails C1 [Witzel, John] Paladin South, Kandahar, Afghanistan. [Witzel, John] US ARMY, Adelphi, MD 20783 USA. RP Witzel, J (reprint author), Paladin South, Kandahar, Afghanistan. EM john.witzel@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 EI 1941-0123 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD APR PY 2014 VL 17 IS 2 BP 50 EP 53 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA AH7MM UT WOS:000336317500012 ER PT J AU Nieto-Granda, C Rogers, JG Christensen, HI AF Nieto-Granda, Carlos Rogers, John G., III Christensen, Henrik I. TI Coordination strategies for multi-robot exploration and mapping SO INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH LA English DT Article; Proceedings Paper CT 13th International Symposium on Experimental Robotics(ISER) CY JUN 18-21, 2012 CL Quebec City, CANADA DE Robot team coordination; multi-robot mapping; multi-robot exploration ID SIMULTANEOUS LOCALIZATION; SLAM AB Situational awareness in rescue operations can be provided by teams of autonomous mobile robots. Human operators are required to teleoperate the current generation of mobile robots for such applications; however, teleoperation is increasingly difficult as the number of robots is expanded. As the number of robots is increased, each robot may also interfere with one another and eventually decrease mapping performance. As presented here, through careful consideration of robot team coordination and exploration strategy, large numbers of mobile robots can be allocated to accomplish the mapping task more quickly and accurately. We present both the coordination and exploration strategies and present results from experiments in simulation as well as with up to nine mobile platforms. C1 [Nieto-Granda, Carlos; Christensen, Henrik I.] Georgia Inst Technol, Atlanta, GA 30332 USA. [Rogers, John G., III] US Army Res Lab, Adelphi, MD 20783 USA. RP Rogers, JG (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM john.g.rogers59.civ@mail.mil FU Army Research Lab (ARL) MAST CTA project [329420]; Boeing Corporation [RE236] FX This work was supported by the Army Research Lab (ARL) MAST CTA project (contract number 329420) and the Boeing Corporation (project RE236). NR 27 TC 3 Z9 4 U1 1 U2 22 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0278-3649 EI 1741-3176 J9 INT J ROBOT RES JI Int. J. Robot. Res. PD APR PY 2014 VL 33 IS 4 SI SI BP 519 EP 533 DI 10.1177/0278364913515309 PG 15 WC Robotics SC Robotics GA AG6SH UT WOS:000335548200004 ER PT J AU Savant, G Berger, RC AF Savant, Gaurav Berger, R. C. TI Closure to "Adaptive Time Stepping-Operator Splitting Strategy to Couple Implicit Numerical Hydrodynamic and Water Quality Codes" by Gaurav Savant and R. C. Berger SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Editorial Material C1 [Savant, Gaurav] Dynam Solut LLC, Knoxville, TN 37919 USA. [Savant, Gaurav; Berger, R. C.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Savant, G (reprint author), Dynam Solut LLC, Knoxville, TN 37919 USA. EM Gaurav.Savant@usace.army.mil; Charlie.Berger@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD APR 1 PY 2014 VL 140 IS 4 DI 10.1061/(ASCE)EE.1943-7870.0000822 PG 1 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AC7XH UT WOS:000332747100006 ER PT J AU Krueger, CA Wenke, JC Cho, MS Hsu, JR AF Krueger, Chad A. Wenke, Joseph C. Cho, Mickey S. Hsu, Joseph R. TI Common Factors and Outcome in Late Upper Extremity Amputations After Military Injury SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE combat-related amputation; late amputation; upper extremity amputation ID OPERATION ENDURING FREEDOM; TRAUMATIC LIMB LOSS; CURRENT CONFLICTS; ORTHOPEDIC INJURIES; OIF/OEF CONFLICTS; AMPUTEE SOLDIERS; SEVERITY SCORES; PROSTHETIC USE; IRAQ; RECONSTRUCTION AB Objectives: Much attention has been given to lower extremity amputations that occur more than 90 days after injury, but little focus has been given to analogous upper extremity amputations. The purpose of this study was to determine the reason(s) for desired amputation and the common complications after amputation for those combat-wounded service members who underwent late upper extremity amputation. Design: Retrospective case series. Setting: Tertiary trauma center. Patients/Participants: All US service members who sustained major extremity amputations from September 2001 to July 2011 were analyzed. Intervention: Late (>90 days after injury) upper extremity amputations. Main Outcome Measurements: Amputation level(s), time to amputation, age, number of operations, pre/postoperative complications, reason(s) for desiring amputation, and disability outcomes were analyzed. Results: Seven of 218 (3.2%) upper extremity amputees had a late upper extremity amputation (>90 days from injury to amputation). The mean and median number of days from injury to amputation was 689 and 678, respectively. The most common preamputation complications were loss of wrist or finger motion (7, 100%), neurogenic pain (4, 57%), and heterotopic ossification (4, 57%). Three (43%) patients (2 persistent and 1 new onset) had neurogenic pain and 2 (29%) had heterotopic ossification after amputation. Only 57% (4 of 7) of amputees used their prostheses regularly. Conclusions: Service members undergoing late upper extremity amputation seem to have different pre- and postoperative complications than those patients undergoing late lower extremity amputations. It was common for the amputee to not wear their prostheses and to experience similar complications after amputation, albeit in a less severe form. Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. C1 [Krueger, Chad A.; Cho, Mickey S.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, Ft Sam Houston, TX USA. [Hsu, Joseph R.] Carolinas Med Ctr, Dept Orthopaed Surg, Charlotte, NC 28203 USA. RP Krueger, CA (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM cak0705@gmail.com NR 34 TC 4 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD APR PY 2014 VL 28 IS 4 BP 227 EP 231 DI 10.1097/BOT.0b013e3182a665f5 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AD3NQ UT WOS:000333153200018 PM 23912860 ER PT J AU Thompson, NB Kelly, DM Warner, WC Rush, JK Moisan, A Hanna, WR Beaty, JH Spence, DD Sawyer, JR AF Thompson, Norfleet B. Kelly, Derek M. Warner, William C., Jr. Rush, Jeremy K. Moisan, Alice Hanna, W. Rick, Jr. Beaty, James H. Spence, David D. Sawyer, Jeffrey R. TI Intraobserver and Interobserver Reliability and the Role of Fracture Morphology in Classifying Femoral Shaft Fractures in Young Children SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE femoral fracture; classification; interobserver and intraobserver reliability ID CALVE-PERTHES-DISEASE; CLASSIFICATION-SYSTEM; IDIOPATHIC SCOLIOSIS; NONACCIDENTAL INJURY; ABUSE; EXPERIENCE; PATTERNS; TRAUMA; LEVEL; LENKE AB Background: Spiral fractures of long bones have long been cited as indications of non-accidental trauma (NAT) in children; however, fracture types are only loosely defined in the literature, and intraobserver and interobserver variability in defining femoral fracture patterns is rarely mentioned. We sought to determine reliability in classifying femoral fractures in young children using a standard series of radiographs shown to physicians with varied backgrounds and training and to determine if a quantitative approach based on objective measurements made on plain radiographs could improve definition of these fractures. Methods: On 50 radiographs, the fracture ratio-fracture length divided by bone diameter-was determined and radiographs were reviewed by 14 observers, including pediatric orthopaedic surgeons, emergency room physicians, and musculoskeletal radiologists, who classified the fractures as transverse, oblique, or spiral. A second review of the images in a different order was carried out at least 10 days after the first. Results: Overall, intraobserver agreement was strong, whereas interobserver reliability was moderate. Experience level did not correlate with either result. Complete agreement among all observers occurred for only 5 fractures: 3 transverse and 2 spiral. An average fracture ratio near 1.0 appeared to be predictiveof a transverse fracture and a ratio of > 3.0, a spiral fracture; ratios between these 2 values resulted in essentially random classification. Conclusions: The ability to reproducibly classify femoral fractures in young children is highly variable among physicians of different specialties. These results support the belief that fracture morphology has little predictive value in NAT because of the wide variability in what observers classify as a spiral fracture of the femur. Caution should be used in the use of descriptive terms such as spiral, oblique, or transverse when classifying femoral fractures, as well as when evaluating children for possible NAT, because of the variability in classification. Level of Evidence: Level III-diagnostic study. C1 [Thompson, Norfleet B.; Kelly, Derek M.; Warner, William C., Jr.; Beaty, James H.; Spence, David D.; Sawyer, Jeffrey R.] Campbell Clin, Dept Orthopaed Surg, Germantown, TN 38138 USA. [Hanna, W. Rick, Jr.] Univ Tennessee, Dept Pediat, Knoxville, TN USA. [Thompson, Norfleet B.; Kelly, Derek M.; Warner, William C., Jr.; Moisan, Alice; Hanna, W. Rick, Jr.; Beaty, James H.; Spence, David D.; Sawyer, Jeffrey R.] Le Bonheur Childrens Hosp, Memphis, TN USA. [Rush, Jeremy K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Sawyer, JR (reprint author), 1211 Union Ave,Suite 510, Memphis, TN 38104 USA. EM jsawyer@campbellclinic.com NR 27 TC 1 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD APR-MAY PY 2014 VL 34 IS 3 BP 352 EP 358 DI 10.1097/BPO.0000000000000095 PG 7 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA AG8WE UT WOS:000335698200018 PM 24172678 ER PT J AU Serrat-Capdevila, A Valdes, JB Stakhiv, EZ AF Serrat-Capdevila, Aleix Valdes, Juan B. Stakhiv, Eugene Z. TI WATER MANAGEMENT APPLICATIONS FOR SATELLITE PRECIPITATION PRODUCTS: SYNTHESIS AND RECOMMENDATIONS(1) SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE satellite precipitation products; monitoring; hydrologic prediction; water management recommendations ID DISTRIBUTED HYDROLOGICAL MODEL; RAINFALL PRODUCTS; GLOBAL PRECIPITATION; PASSIVE MICROWAVE; GAUGE OBSERVATIONS; ANALYSIS TMPA; INFRARED DATA; RIVER-BASIN; RESOLUTION; ERROR AB This article is an assessment of the current state of the art and relative utility of satellite precipitation products (SPPs) for hydrologic applications to support water management decisions. We present a review of SPPs, their accuracy in diverse settings including the influence of geography, topography, and weather systems, as well as the pros and cons of their use for different water management applications. At the end of this broad synthesizing effort, recommendations are proposed for: (1) SPP developers to improve the quality, usability, and relevance of precipitation products; and (2) SPP users to improve the reliability of their predictions and hydrologic applications to better support water management. C1 [Serrat-Capdevila, Aleix; Valdes, Juan B.] Univ Arizona, Dept Hydrol & Water Resources, Tucson, AZ 85721 USA. [Serrat-Capdevila, Aleix] US Army Corps Engineers, Inst Water Resources, Int Ctr Integrated Water Resources Management ICI, Natl Res Council, Alexandria, VA 22315 USA. [Valdes, Juan B.; Stakhiv, Eugene Z.] US Army Corps Engineers, Inst Water Resources, Int Ctr Integrated Water Resources Management ICI, Alexandria, VA 22315 USA. [Stakhiv, Eugene Z.] Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. RP Serrat-Capdevila, A (reprint author), Univ Arizona, Dept Hydrol & Water Resources, 1133 E James E Rogers Way,JW Harshbarger Bldg, Tucson, AZ 85721 USA. EM aleix@email.arizona.edu RI Serrat-Capdevila, Aleix/O-6227-2014 FU International Center for Integrated Water Resources Management (ICIWaRM-UNESCO), through a National Research Council; NASA SERVIR program; NSF-CNIC program FX This work was supported by the International Center for Integrated Water Resources Management (ICIWaRM-UNESCO), especially through a National Research Council fellowship for the first author. Partial support was also provided by the NASA SERVIR program, as well as the NSF-CNIC program. Three anonymous reviewers provided invaluable comments. All contributions are gratefully acknowledged. NR 70 TC 11 Z9 11 U1 0 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD APR PY 2014 VL 50 IS 2 BP 509 EP 525 DI 10.1111/jawr.12140 PG 17 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AE0WM UT WOS:000333687000020 ER PT J AU Villamaria, CY Eliason, JL Napolitano, LM Stansfield, RB Spencer, JR Rasmussen, TE AF Villamaria, Carole Y. Eliason, Jonathan L. Napolitano, Lena M. Stansfield, R. Brent Spencer, Jerry R. Rasmussen, Todd E. TI Endovascular Skills for Trauma and Resuscitative Surgery (ESTARS) course: Curriculum development, content validation, and program assessment SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Endovascular; trauma; hemorrhage; resuscitation; aortic balloon occlusion ID NONCOMPRESSIBLE TORSO HEMORRHAGE; AORTIC BALLOON OCCLUSION; CHANGING LANDSCAPE; VASCULAR TRAUMA; EVOLVING ROLE; MANAGEMENT; EPIDEMIOLOGY; SHOCK; INJURY; MODEL AB BACKGROUND The management of hemorrhage shock requires support of central aortic pressure including perfusion to the brain and heart as well as measures to control bleeding. Emerging endovascular techniques including resuscitative endovascular balloon occlusion of the aorta serve as potential lifesaving adjuncts in this setting. The Endovascular Skills for Trauma and Resuscitative Surgery (ESTARS) course was developed to provide fundamental endovascular training for trauma surgeons. METHODS ESTARS 2-day course incorporated pretest/posttest examinations, precourse materials, lectures, endovascular and open vascular instruments, Vascular Intervention System Trainer endovascular simulator, and live animal laboratories for training and testing. Curriculum included endovascular techniques for trauma; review of wires, sheaths, and catheters; as well as regional vascular injury management. Animal laboratories integrated arterial access, angiography, coil embolization, resuscitative endovascular balloon occlusion of the aorta, control of iliac artery injury, and vascular shunt placement. Students completed a knowledge test (precourse/postcourse) and a summative skills assessment. The test measured knowledge and judgment in vascular injury management as defined in the course objectives. Vascular Intervention System Trainer and animal laboratory were used for final examinations. Subjective performance was graded by expert observers using a global assessment scale and performance metrics. RESULTS Four pilot ESTARS courses were completed, with four participants each. Knowledge and performance significantly improved after ESTARS. Mean test examination scores increased by 77% to 85%, with a mean change of 9 percentage points [paired t (15) = 7.82, p < 0.0001]. The test was unidimensional (Cronbach's = 0.67). Technical skill significantly improved for both endovascular simulation and live animal laboratory examinations. All participants passed the live animal laboratory practical examination. CONCLUSION The ESTARS curriculum is effective at teaching a basic set of endovascular skills for resuscitation and hemorrhage control to trauma surgeons. ESTARS was confirmed as a stepwise and hierarchical curriculum demonstrating measurable improvements in performance metrics and should serve as a model for future competency-based structured training in endovascular trauma skills. C1 [Villamaria, Carole Y.] Univ Texas San Antonio, San Antonio, TX USA. [Eliason, Jonathan L.; Napolitano, Lena M.; Stansfield, R. Brent] Univ Michigan, San Antonio, TX USA. [Spencer, Jerry R.] Lackland AFB, Div Clin Res, San Antonio, TX USA. [Rasmussen, Todd E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Napolitano, LM (reprint author), Univ Michigan Hlth Syst, Univ Hosp, Dept Surg, Room 1C340A UH,1500 East Med Dr, Ann Arbor, MI 48109 USA. EM lenan@umich.edu OI Stansfield, R. Brent/0000-0002-3825-3631 FU Department of Defense [F029024] FX This study was funded by the Department of Defense Award F029024-Vascular Injury Advanced Training. NR 31 TC 23 Z9 24 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2014 VL 76 IS 4 BP 929 EP 935 DI 10.1097/TA.0000000000000164 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AE7FF UT WOS:000334161500008 PM 24662854 ER PT J AU Orton, SL Chiarito, VP Rabalais, C Wombacher, M Rowell, SP AF Orton, Sarah L. Chiarito, Vincent P. Rabalais, Christopher Wombacher, Matthew Rowell, Stephen P. TI Strain Rate Effects in CFRP Used For Blast Mitigation SO POLYMERS LA English DT Article DE carbon fiber reinforced polymers; blast loads; reinforced concrete; strain rate; tensile strength ID CONCRETE SLABS; COMPOSITE-MATERIALS; FIBER; STRENGTH; BEHAVIOR AB The purpose of this research is to gain a better understanding of strain rate effects in carbon fiber reinforced polymer (CFRP) laminates exposed to blast loading. The use of CFRP offers an attractive option for mitigating structures exposed to blasts. However, the effect of high strain rates in CFRP composites commonly used in the civil industry is unknown. This research conducted tensile tests of 21 CFRP coupons using a hydraulically powered dynamic loader. The strain rates ranged from 0.0015 s(-1) to 7.86 s(-1) and are representative of strain rates that CFRP may see in a blast when used to strengthen reinforced concrete structures. The results of the testing showed no increase in the tensile strength or stiffness of the CFRP at the higher strain rates. In addition, the results showed significant scatter in the tensile strengths possibly due to the rate of loading or manufacture of the coupon. C1 [Orton, Sarah L.; Wombacher, Matthew] Univ Missouri, Columbia, MO 65211 USA. [Chiarito, Vincent P.; Rabalais, Christopher; Rowell, Stephen P.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Orton, SL (reprint author), Univ Missouri, E2503 Lafferre Hall, Columbia, MO 65211 USA. EM ortons@missouri.edu; Vincent.P.Chiarito@usace.army.mil; Christopher.P.Rabalais@usace.army.mil; mtwf35@mail.missouri.edu; Stephen.p.rowell@usace.army.mil FU Science and Technology Directorate of the Department of Homeland Security FX This research effort was supported by the Science and Technology Directorate of the Department of Homeland Security. Permission to publish was granted by the Department of Homeland Security and the Director, Geotechnical & Structures Laboratory. NR 21 TC 3 Z9 3 U1 3 U2 16 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4360 J9 POLYMERS-BASEL JI Polymers PD APR PY 2014 VL 6 IS 4 BP 1026 EP 1039 DI 10.3390/polym6041026 PG 14 WC Polymer Science SC Polymer Science GA AH1QR UT WOS:000335896500005 ER PT J AU Han, GS Stromdahl, EY Wong, D Weltman, AC AF Han, George S. Stromdahl, Ellen Y. Wong, David Weltman, Andre C. TI Exposure to Borrelia burgdorferi and Other Tick-Borne Pathogens in Gettysburg National Military Park, South-Central Pennsylvania, 2009 SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Ixodes scapularis; Borrelia burgdorferi; Lyme disease; Gettysburg National Military Park; Tick-borne pathogens ID LYME-DISEASE; UNITED-STATES; AMBLYOMMA-AMERICANUM; HUMAN RISK; IXODIDAE; ACARI; INFECTION; VECTOR; HEALTH; AGENT AB Since 1998, Lyme disease cases have increased in south-central Pennsylvania, which includes Gettysburg National Military Park (NMP). Limited information is available about tick populations or pathogens in this area, and no data regarding frequency of tick bites or prevention measures among Gettysburg NMP employees are available. To address these gaps, ticks were collected, classified, and replaced (to minimize disruptions to tick populations) at two sites within Gettysburg NMP during April-September, 2009, among eight nonremoval samplings. On two additional occasions during May and June, 2009, ticks were collected and removed from the two original sites plus 10 additional sites and tested for tick-borne pathogens by using PCR. A self-administered anonymous survey of Gettysburg NMP employees was conducted to determine knowledge, attitudes, and practices regarding tick-borne diseases. Peak Ixodes scapularis nymph populations were observed during May-July. Of 115 I. scapularis ticks tested, 21% were infected with Borrelia burgdorferi, including 18% of 74 nymphs and 27% of 41 adults; no other pathogen was identified. The entomologic risk index was calculated at 1.3 infected nymphs/hour. An adult and nymph Amblyomma americanum were also found, representing the first confirmed field collection of this tick in Pennsylvania, but no pathogens were detected. The survey revealed that most park employees believed Lyme disease was a problem at Gettysburg NMP and that they frequently found ticks on their skin and clothing. However, use of personal preventive measures was inconsistent, and 6% of respondents reported contracting Lyme disease while employed at Gettysburg NMP. These findings indicate a need to improve surveillance for tick bites among employees and enhance prevention programs for park staff and visitors. C1 [Han, George S.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Han, George S.; Weltman, Andre C.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Stromdahl, Ellen Y.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21084 USA. [Wong, David] Natl Pk Serv Off Publ Hlth, Albuquerque, NM USA. RP Stromdahl, EY (reprint author), US Army Publ Hlth Command, 5158 Blackhawk Rd,BLDG E-5800, Aberdeen Proving Ground, MD 21084 USA. EM ellen.y.stromdahl.civ@mail.mil FU National Park Service Office of Public Health FX The authors thank the numerous persons from the Pennsylvania Department of Health, the U. S. Army Public Health Command, and the U. S. Army 1st and 9th Area Medical Laboratories who assisted in tick sampling efforts. We also thank Mary Vince and the Tick-Borne Disease Laboratory for their contribution to the laboratory identification of tick pathogens and the National Park Service Office of Public Health for providing funding for tick pathogen testing. We thank Zach Bolitho and the administrators and employees of Gettysburg National Military Park and Eisenhower National Historic Site for their participation in the survey and assistance with selecting tick-sampling sites, as well as Gettysburg College professor Steven James for local background information. Finally, we acknowledge the contributions of Rebecca Eisen, Heidi Brown, Paul Mead, Kevin Griffith, and Joseph Piesman of the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC for providing invaluable feedback regarding the study design, tick sampling protocols, and the employee survey. NR 24 TC 4 Z9 4 U1 0 U2 14 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD APR PY 2014 VL 14 IS 4 BP 227 EP 233 DI 10.1089/vbz.2013.1363 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AH8FX UT WOS:000336372200001 PM 24689815 ER PT J AU Sadhu, B Sturm, M Sadler, BM Harjani, R AF Sadhu, Bodhisatwa Sturm, Martin Sadler, Brian M. Harjani, Ramesh TI Building an On-Chip Spectrum Sensor for Cognitive Radios SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article ID CMOS; RECEIVER; ACCESS AB Next generation cognitive radio networks require an RF and mixed signal hardware architecture that can achieve low-energy, very wide-band spectrum sensing. We survey state-of-the-art low-power CMOS building blocks as potential candidates for realizing such an architecture. For the critical analog-to-digital converter, we compare time-interleaved and frequency-interleaved architectures, including system-level simulations, and frequency-interleaving is shown to provide significant advantages. Measurement results from a 3.8 mW 5 GHz bandwidth analog domain frequency interleaver are presented to confirm the possibility of a very low-energy frequency domain digitizer. Coupled with DSP for calibration and signal feature extraction, this architecture has significant promise for cognitive spectrum sensing. C1 [Sadhu, Bodhisatwa] IBM TJ Watson Res Ctr, New York, NY 10598 USA. [Sturm, Martin] Univ Minnesota, Minneapolis, MN USA. [Harjani, Ramesh] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD USA. RP Sadhu, B (reprint author), IBM TJ Watson Res Ctr, New York, NY 10598 USA. EM sadhu002@umn.edu RI Sadhu, Bodhisatwa/K-7176-2014 OI Sadhu, Bodhisatwa/0000-0002-5849-9006 NR 15 TC 6 Z9 6 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD APR PY 2014 VL 52 IS 4 BP 92 EP 100 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AH1XJ UT WOS:000335914800013 ER PT J AU Crone, JC Chung, PW Leiter, KW Knap, J Aubry, S Hommes, G Arsenlis, A AF Crone, Joshua C. Chung, Peter W. Leiter, Kenneth W. Knap, Jaroslaw Aubry, Sylvie Hommes, Gregg Arsenlis, Athanasios TI A multiply parallel implementation of finite element-based discrete dislocation dynamics for arbitrary geometries SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article DE dislocation dynamics; free surface; image stress ID BOUNDARY-VALUE PROBLEM; MESOSCOPIC SCALE; FREE-SURFACE; MULTISCALE MODEL; SINGLE-CRYSTALS; IMAGE STRESSES; PLASTICITY; SIMULATION; DEFECTS; DEFORMATION AB Discrete dislocation dynamics (DD) approaches have proven useful in modeling the dynamics of large ensembles of dislocations. Continuing interest in finite body effects via image stresses has extended DD numerical approaches to improve the handling of surfaces. However, a physically accurate, yet computationally scalable, implementation has been elusive. This paper presents a new framework and implementation of a finite element-based discrete DD code that (1) treats arbitrarily shaped non-convex surfaces through image tractions, (2) allows for systematic refinement of the finite element mesh both in the bulk and on the surface and (3) provides a platform to scale to relatively larger and lengthier simulations. The approach is based on the capabilities of the Parallel Dislocation Simulator coupled through a distributed shared memory implementation for the calculation of large numbers of dislocation segments interacting with an independently large number of surface finite elements. Surface tracking approaches enable topological features at surfaces to be modeled. We verify the computed results via comparisons with analytical solutions for an infinite screw dislocation and prismatic loop near a surface and examine surface effects on a Frank-Read source. Convergence of the image force error with h- and p-refinement is shown to indicate the computational robustness. Additionally, through larger numerical experiments, we demonstrate the new capabilities in a three-dimensional elastic body of finite extent. C1 [Crone, Joshua C.; Chung, Peter W.; Leiter, Kenneth W.; Knap, Jaroslaw] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Aubry, Sylvie; Hommes, Gregg; Arsenlis, Athanasios] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. RP Crone, JC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joshua.crone.civ@mail.mil FU Army Program Element [0601102A H44]; Computational Sciences Division at the US Army Research Laboratory; US Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX This research was performed through support, in part, from Army Program Element 0601102A H44 and the Computational Sciences Division at the US Army Research Laboratory and, in part, through the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Computing resources were provided by the Department of Defense (DoD) Supercomputing Resource Center (DSRC). NR 59 TC 7 Z9 7 U1 0 U2 19 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 EI 1361-651X J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD APR PY 2014 VL 22 IS 3 AR 035014 DI 10.1088/0965-0393/22/3/035014 PG 27 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA AH2LM UT WOS:000335952900024 ER PT J AU Ghahramanlou-Holloway, M Tucker, J Neely, LL Carreno-Ponce, JT Ryan, K Holloway, K George, B AF Ghahramanlou-Holloway, Marjan Tucker, Jennifer Neely, Laura L. Carreno-Ponce, Jaime T. Ryan, Katheryn Holloway, Kathryn George, Brianne TI Suicide Risk among Military Women SO PSYCHIATRIC ANNALS LA English DT Article ID DEPRESSION; VETERANS; SYMPTOMS; CARE AB There is limited scientific literature on suicidal self-directed violence among military women. When compared with their civilian counterparts, military women are at a three-fold increased risk for suicide and, once they enter Veteran status, they are 79% more likely to die by suicide than civilian women. This article provides an overview of the problem of suicide among military women. Guidance on how to best assess and manage suicide risk among military women is provided. Providers are encouraged to adopt a bio-psychosocial approach and carefully evaluate each patient's traumatic life events, history of self-injurious behaviors with and without intention to die, postpartum depression, psychosis, relational problems, other psychiatric conditions, and/or occupational stressors. A series of clinical recommendations, such as implementing a safety plan, are discussed. Advances in epidemiologic and behavioral health research are needed to best understand the suicide risk assessment and treatment needs of military women. C1 [Ghahramanlou-Holloway, Marjan] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Tucker, Jennifer; Neely, Laura L.; Ryan, Katheryn; Holloway, Kathryn; George, Brianne] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Lab Treatment Suicide Related Ideat & Behav, Bethesda, MD 20814 USA. [Carreno-Ponce, Jaime T.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Lab Treatment Suicide Related Ideat & Behav, US Army, Bethesda, MD 20814 USA. RP Ghahramanlou-Holloway, M (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd,Room B3050, Bethesda, MD 20814 USA. EM marjan.holloway@usuhs.edu NR 30 TC 0 Z9 0 U1 3 U2 6 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 EI 1938-2456 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD APR PY 2014 VL 44 IS 4 BP 189 EP 193 DI 10.3928/00485713-20140403-06 PG 5 WC Psychiatry SC Psychiatry GA AH2LC UT WOS:000335951800006 ER PT J AU Muth, ER Scisco, JL Jasper, PW Parker, VG AF Muth, Eric R. Scisco, Jenna L. Jasper, Phillip W. Parker, Veronica G. TI EATING PATTERN DIFFERENCES IN AFRICAN AMERICANS AND CAUCASIANS IN FREE-LIVING MEALS MEASURED WITH THE BITE COUNTER SO PSYCHOSOMATIC MEDICINE LA English DT Meeting Abstract CT 72nd Annual Meeting of the American-Psychosomatic-Society CY MAR 12-15, 2014 CL San Francisco, CA SP Amer Psychosomat Soc C1 [Muth, Eric R.] Clemson Univ, Clemson, SC USA. [Scisco, Jenna L.] US Army, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Jasper, Phillip W.; Parker, Veronica G.] Clemson Univ, Sch Nursing, Clemson, SC USA. RI Parker, Veronica/I-5160-2013 OI Parker, Veronica/0000-0002-5217-4569 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 EI 1534-7796 J9 PSYCHOSOM MED JI Psychosom. Med. PD APR PY 2014 VL 76 IS 3 BP A7 EP A8 PG 2 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA AE8FN UT WOS:000334235100031 ER PT J AU Schafer, JL Breslow, BP Hollingsworth, SN Hohmann, MG Hoffmann, WA AF Schafer, Jennifer L. Breslow, Bradley P. Hollingsworth, Stephanie N. Hohmann, Matthew G. Hoffmann, William A. TI Size-dependent enhancement of water relations during post-fire resprouting SO TREE PHYSIOLOGY LA English DT Article DE leaf area; leaf-specific whole-plant hydraulic conductance; mid-day leaf water potential; root hydraulic conductance; stem height; stomatal conductance ID NEOTROPICAL SAVANNA TREES; HYDRAULIC CONDUCTANCE; STOMATAL CONTROL; PRESCRIBED-FIRE; PONDEROSA PINE; PREDAWN PLANT; GAS-EXCHANGE; FINE-ROOT; GROWTH; SOIL AB In resprouting species, fire-induced topkill causes a reduction in height and leaf area without a comparable reduction in the size of the root system, which should lead to an increase in the efficiency of water transport after fire. However, large plants undergo a greater relative reduction in size, compared with small plants, so we hypothesized that this enhancement in hydraulic efficiency would be greatest among large growth forms. In the ecotone between long-leaf pine (Pinus palustris Mill.) savannas and wetlands, we measured stomatal conductance (g(s)), mid-day leaf water potential (Psi(leaf)), leaf-specific whole-plant hydraulic conductance (K-L.p), leaf area and height of 10 species covering a range of growth forms in burned and unburned sites. As predicted, K-L.p was higher in post-fire resprouts than in unburned plants, and the post-fire increase in K-L.p was positively related to plant size. Specifically, large-statured species tended to undergo the greatest relative reductions in leaf area and height, and correspondingly experienced the greatest increases in K-L.p. The post-fire increase in K-L.p was smaller than expected, however, due to a decrease in absolute root hydraulic conductance (i.e., not scaled to leaf area). The higher K-L.p in burned sites was manifested as an increase in gs rather than an increase in Psi(leaf). Post-fire increases in gs should promote high rates of photosynthesis for recovery of carbohydrate reserves and aboveground biomass, which is particularly important for large-statured species that require more time to recover their pre-fire size. C1 [Schafer, Jennifer L.; Breslow, Bradley P.; Hollingsworth, Stephanie N.; Hoffmann, William A.] N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Schafer, JL (reprint author), N Carolina State Univ, Dept Plant & Microbial Biol, 2115 Gardner Hall,Box 7612, Raleigh, NC 27695 USA. EM jlschafe@ncsu.edu FU US Army Engineer Research and Development Center; North Carolina State University [W9132T-11-2-0007] FX This research was supported by a cooperative agreement between the US Army Engineer Research and Development Center and North Carolina State University (W9132T-11-2-0007 to W.A.H.). NR 61 TC 1 Z9 1 U1 9 U2 33 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0829-318X EI 1758-4469 J9 TREE PHYSIOL JI Tree Physiol. PD APR PY 2014 VL 34 IS 4 BP 404 EP 414 DI 10.1093/treephys/tpu015 PG 11 WC Forestry SC Forestry GA AH1PA UT WOS:000335892100008 PM 24682534 ER PT J AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung TI Optimal Sparse Kernel Learning in the Empirical Kernel Feature Space for Hyperspectral Classification SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Empirical kernel feature space (EKFS); empirical kernel map; optimal feature selection; sparse kernel learning ID SELECTION AB In this paper, a novel framework for optimal sparse kernel learning for support vector machine (SVM) classifier in a finite-dimensional space called the empirical kernel feature space (EKFS) is presented. In conventional sparse kernel learning techniques, feature selection algorithms are optimal up to linear kernel because the contributions of individual features in the input space to the margin of the classifier can be determined explicitly for a linear kernel. But the use of nonlinear kernels leads to high dimensional, possibly infinite dimensional, Reproducing Kernel Hilbert Spaces (RKHS). Here, feature selection problem is highly combinatorial, and is NP-hard to solve because the number of all the possible combinations of the input features mapped from the input space into the RKHS is often prohibitively large to determine the contributions of subsets of features. To tackle this issue, in the proposed work, feature selection is explicitly and optimally performed in the EKFS instead of in the corresponding RKHS. Unlike the RKHS, the EKFS associated with any positive definite kernel including Gaussian RBF kernel can explicitly be built by using empirical kernel mapping. The feature selection in the EKFS has the same effect as the feature selection in the RKHS since both the EKFS and RKHS associated with same kernel have the same geometrical structure. The features in the EKFS are a kernel representation of each input vector with respect to all the training samples available. Thus, they represent nonlinear similarity measure of each data point with respect to reference samples with known labels. The proposed sparse kernel learning can optimally select multiple subsets of newly mapped features in the EKFS in order to improve the generalization performance of the classifier. The sparse kernel-based learning is tested on several hyperspectral datasets and a performance comparison among different feature selection techniques is presented. C1 [Gurram, Prudhvi; Kwon, Heesung] US Army Res Lab, Image Proc Branch, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), US Army Res Lab, Image Proc Branch, Adelphi, MD 20783 USA. EM pkgurram@gmail.com; heesung.kwon.civ@mail.mil NR 22 TC 3 Z9 3 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD APR PY 2014 VL 7 IS 4 BP 1217 EP 1226 DI 10.1109/JSTARS.2014.2314262 PG 10 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA AG4LB UT WOS:000335390000020 ER PT J AU Doyle, JD Howard, IL Gartrell, CA Anderton, GL Newman, JK Berney, ES AF Doyle, Jesse D. Howard, Isaac L. Gartrell, Chad A. Anderton, Gary L. Newman, J. Kent Berney, Ernest S. TI Full-Scale Instrumented Testing and Three-Dimensional Modeling of Airfield Matting Systems SO INTERNATIONAL JOURNAL OF GEOMECHANICS LA English DT Article DE Full-scale tests; Instrumentation; Finite-element method; Three-dimensional analysis; Airport and airfield runways AB Matting systems are used for temporary applications on soft soils to reduce ground pressure exerted by aircraft, heavy equipment, vehicles, and construction material. They have been used for military airfields, construction platforms, and similar applications. Previous evaluation studies of matting systems have typically consisted of full-scale testing, with only a limited amount of numerical modeling found in the literature. This paper presents results of full-scale accelerated testing of 21 test sections encompassing five matting systems, five soil-support conditions, and two aircraft loadings. One of the soil-support conditions was instrumented and tested in conjunction with three matting systems and one aircraft loading. Three-dimensional finite-element modeling was performed on the instrumented sections using the measured test data for calibration. Good matches of measured soil stresses were obtained with the model for two of the mats, whereas the model underpredicted stresses in the third mat. Modeling of the type performed in this paper was capable of correctly ranking the performance of the matting systems modeled relative to the full-scale test results. C1 [Doyle, Jesse D.; Gartrell, Chad A.; Newman, J. Kent; Berney, Ernest S.] US Army COE USACE, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. [Anderton, Gary L.] US Army COE USACE, Engineer Res & Dev Ctr, Geotech & Struct Lab, Airfields & Pavements Branch, Vicksburg, MS 39180 USA. RP Doyle, JD (reprint author), US Army COE USACE, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jesse.D.Doyle@usace.army.mil; ilhoward@cee.msstate.edu; Chad.A.Gartrell@usace.army.mil; Gary.L.Anderton@usace.army.mil; John.K.Newman@usace.army.mil; Ernest.S.Berney.IV@usace.army.mil NR 17 TC 7 Z9 9 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1532-3641 EI 1943-5622 J9 INT J GEOMECH JI Int. J. Geomech. PD APR 1 PY 2014 VL 14 IS 2 BP 161 EP 170 DI 10.1061/(ASCE)GM.1943-5622.0000272 PG 10 WC Engineering, Geological SC Engineering GA AG4HM UT WOS:000335380300001 ER PT J AU Buczak, AL Baugher, B Babin, SM Ramac-Thomas, LC Guven, E Elbert, Y Koshute, PT Velasco, JMS Roque, VG Tayag, EA Yoon, IK Lewis, SH AF Buczak, Anna L. Baugher, Benjamin Babin, Steven M. Ramac-Thomas, Liane C. Guven, Erhan Elbert, Yevgeniy Koshute, Phillip T. Velasco, John Mark S. Roque, Vito G., Jr. Tayag, Enrique A. Yoon, In-Kyu Lewis, Sheri H. TI Prediction of High Incidence of Dengue in the Philippines SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID OUTBREAK DETECTION; FEVER; SURVEILLANCE; DISEASES; TRANSMISSION; TEMPERATURE; INFECTIONS; DYNAMICS; FOREST; VIRUS AB Background Accurate prediction of dengue incidence levels weeks in advance of an outbreak may reduce the morbidity and mortality associated with this neglected disease. Therefore, models were developed to predict high and low dengue incidence in order to provide timely forewarnings in the Philippines. Methods Model inputs were chosen based on studies indicating variables that may impact dengue incidence. The method first uses Fuzzy Association Rule Mining techniques to extract association rules from these historical epidemiological, environmental, and socio-economic data, as well as climate data indicating future weather patterns. Selection criteria were used to choose a subset of these rules for a classifier, thereby generating a Prediction Model. The models predicted high or low incidence of dengue in a Philippines province four weeks in advance. The threshold between high and low was determined relative to historical incidence data. Principal Findings Model accuracy is described by Positive Predictive Value (PPV), Negative Predictive Value (NPV), Sensitivity, and Specificity computed on test data not previously used to develop the model. Selecting a model using the F-0.5 measure, which gives PPV more importance than Sensitivity, gave these results: PPV = 0.780, NPV = 0.938, Sensitivity = 0.547, Specificity = 0.978. Using the F-3 measure, which gives Sensitivity more importance than PPV, the selected model had PPV = 0.778, NPV = 0.948, Sensitivity = 0.627, Specificity = 0.974. The decision as to which model has greater utility depends on how the predictions will be used in a particular situation. Conclusions This method builds prediction models for future dengue incidence in the Philippines and is capable of being modified for use in different situations; for diseases other than dengue; and for regions beyond the Philippines. The Philippines dengue prediction models predicted high or low incidence of dengue four weeks in advance of an outbreak with high accuracy, as measured by PPV, NPV, Sensitivity, and Specificity. Author Summary A largely automated methodology is described for creating models that use past and recent data to predict dengue incidence levels several weeks in advance for a specific time period and a geographic region that can be sub-national. The input data include historical and recent dengue incidence, socioeconomic factors, and remotely sensed variables related to weather, climate, and the environment. Among the climate variables are those known to indicate future weather patterns that may or may not be seasonal. The final prediction models adhere to these principles: 1) the data used must be available at the time the prediction is made (avoiding pitfalls made by studies that use recent data that, in actual practice, would not be available until after the date the prediction was made); and 2) the models are tested on data not used in their development (thereby avoiding overly optimistic measures of accuracy of the prediction). Local public health preferences for low numbers of false positives and negatives are taken into account. These models appear to be robust even when applied to nearby geographic regions that were not used in model development. The method may be applied to other vector borne and environmentally affected diseases. C1 [Buczak, Anna L.; Baugher, Benjamin; Babin, Steven M.; Ramac-Thomas, Liane C.; Guven, Erhan; Elbert, Yevgeniy; Koshute, Phillip T.; Lewis, Sheri H.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Velasco, John Mark S.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Roque, Vito G., Jr.; Tayag, Enrique A.] Natl Epidemiol Ctr, Dept Hlth, Manila, Philippines. RP Buczak, AL (reprint author), Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. EM Anna.Buczak@jhuapl.edu FU U.S. Department of Defense Joint Program Manager, Medical Countermeasures Systems, JPEO-CBD FX Funding for this work is provided by the U.S. Department of Defense Joint Program Manager, Medical Countermeasures Systems, JPEO-CBD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 8 Z9 8 U1 0 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2014 VL 8 IS 4 DI 10.1371/journal.pntd.0002771 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AG3TK UT WOS:000335342400012 PM 24722434 ER PT J AU Nunes, MRT Palacios, G Faria, NR Sousa, EC Pantoja, JA Rodrigues, SG Carvalho, VL Medeiros, DBA Savji, N Baele, G Suchard, MA Lemey, P Vasconcelos, PFC Lipkin, WI AF Nunes, Marcio R. T. Palacios, Gustavo Faria, Nuno Rodrigues Sousa, Edivaldo Costa, Jr. Pantoja, Jamilla A. Rodrigues, Sueli G. Carvalho, Valeria L. Medeiros, Daniele B. A. Savji, Nazir Baele, Guy Suchard, Marc A. Lemey, Philippe Vasconcelos, Pedro F. C. Lipkin, W. Ian TI Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1-3 in Brazil SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID STATISTICAL PHYLOGENETICS; EVOLUTIONARY DYNAMICS; SEQUENCE ALIGNMENT; PHYLOGEOGRAPHY; MODEL; REPLACEMENT; PERFORMANCE; INTERFACE; EMERGENCE; SELECTION AB Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil. Author Summary Dengue virus serotypes are associated with millions of infections and thousands of deaths globally each year, primarily in tropical and subtropical regions. We investigated the spatial dynamics of DENV (serotypes 1-3) in Brazil by applying a statistical framework to complete genome sequences. Co-circulation of distinct genotypes, lineage extinction and replacement and multiple viral introduction events were found for all three serotypes. New lineages were typically introduced from the Caribbean into Northern Brazil and dispersed thereafter at a rate of approximate to 0.5 km/year. Our analysis indicates that aerial transportation is a more important determinant of viral dispersal than Aedes aegypti infestation rates or geographical distance. C1 [Nunes, Marcio R. T.; Sousa, Edivaldo Costa, Jr.; Pantoja, Jamilla A.] Inst Evandro Chagas, Ctr Inovacao Tecnol, Ananindeua, Brazil. [Palacios, Gustavo] US Army, Ctr Genom Sci, Med Res Inst Infect Dis, Frederick, MD USA. [Palacios, Gustavo; Savji, Nazir; Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY USA. [Faria, Nuno Rodrigues; Baele, Guy; Lemey, Philippe] Univ Oxford, Dept Zool, Oxford OX1 3PS, England. [Rodrigues, Sueli G.; Carvalho, Valeria L.; Medeiros, Daniele B. A.; Vasconcelos, Pedro F. C.] Inst Evandro Chagas, Dept Arbovirol & Febres Hemorrag, Ananindeua, Brazil. [Suchard, Marc A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA. [Suchard, Marc A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA. [Suchard, Marc A.] Univ Calif Los Angeles, UCLA Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA USA. [Vasconcelos, Pedro F. C.] Univ Estado Para, Belem, Para, Brazil. RP Nunes, MRT (reprint author), Inst Evandro Chagas, Ctr Inovacao Tecnol, Ananindeua, Brazil. EM marcionunes@iec.pa.gov.br RI Faria, Nuno/I-2975-2012; Palacios, Gustavo/I-7773-2015; Nunes, Marcio Roberto/B-2238-2016 OI Faria, Nuno/0000-0001-8839-2798; Palacios, Gustavo/0000-0001-5062-1938; Rodrigues Faria, Nuno/0000-0002-9747-8822; Nunes, Marcio Roberto/0000-0001-9739-5499 FU National Institute of Science and Technology for Viral Hemorrhagic Fevers (INCT-FHV) [CNP/FAPESPA/CAPES 573739/2008-0]; CNPQ [302032/2011-8, 301421/2010-2]; Fundacao para a Ciencia e Tecnologia [SFRH/BD/64530/2009]; European Union Seventh Framework Programme (FP7) [278433-PREDEMICS]; ERC [260864]; US National Science Foundation [DMS 0856099]; US National Institutes of Health [R01 GM086887, R01 HG006139]; National Institutes of Health (NIAID); USAID (PREDICT) FX This study was partially supported by the National Institute of Science and Technology for Viral Hemorrhagic Fevers (INCT-FHV grant CNP/FAPESPA/CAPES 573739/2008-0), MRTN is supported by CNPQ (grant 302032/2011-8). PFCV is supported by CNPq (grant 301421/2010-2). NRF is supported by Fundacao para a Ciencia e Tecnologia under grant agreement no. SFRH/BD/64530/2009. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 278433-PREDEMICS and ERC grant agreement no. 260864, the US National Science Foundation (DMS 0856099) and the US National Institutes of Health (R01 GM086887 and R01 HG006139). Work in the Center for Infection and Immunity is supported by grants from the National Institutes of Health (NIAID) and USAID (PREDICT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 55 TC 15 Z9 15 U1 0 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2014 VL 8 IS 4 DI 10.1371/journal.pntd.0002769 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AG3TK UT WOS:000335342400043 PM 24743730 ER PT J AU Hsieh, AJ Chantawansri, TL Hu, WG Strawhecker, KE Casem, DT Eliason, JK Nelson, KA Parsons, EM AF Hsieh, Alex J. Chantawansri, Tanya L. Hu, Weiguo Strawhecker, Kenneth E. Casem, Daniel T. Eliason, Jeffrey K. Nelson, Keith A. Parsons, Ethan M. TI New insight into microstructure-mediated segmental dynamics in select model poly(urethane urea) elastomers SO POLYMER LA English DT Article DE Poly(urethane urea) elastomers; Segmental dynamics; Dynamic strain-rate sensitivity ID STRESS-STRAIN BEHAVIOR; STRUCTURE-PROPERTY RELATIONSHIPS; SPIN-DIFFUSION COEFFICIENTS; SOFT SEGMENTS; POLY(PROPYLENE GLYCOL); MECHANICAL DEFORMATION; MONOL CONTENT; POLYUREA; NMR; COPOLYMERS AB Segmental dynamics in a series of 4,4'-dicyclohexylmethane diisocyanate diethyltoluenediamine poly(tetramethylene oxide) based poly(urethane urea) (PUU) elastomers have been investigated through a multi-scale characterization approach. This includes broadband dielectric analysis, solid-state nuclear magnetic resonance (NMR), plate impact, and impulsive stimulated scattering. Dielectric relaxation measurements applicable at frequencies up to 10(6) Hz are useful for interpreting the high strain-rate deformation response; i.e. at the moment of target interaction with an accelerating impact or MHz stress wave excitation. Additionally, the capability of solid-state NMR to differentiate the microstructure-mediated segmental dynamics; correspondingly, the presence of a rigid phase (those in the phase-mixed regions) and a mobile phase associated with the soft-segment domains is demonstrated. These new insights not only further elucidate the microstructure details discerned through atomic force microscopy, but also enable the prediction of the macroscopically dynamic response in these model PUUs, particularly on the temporal scale over the range of mu s-ns. Published by Elsevier Ltd. C1 [Hsieh, Alex J.; Chantawansri, Tanya L.; Strawhecker, Kenneth E.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. [Casem, Daniel T.] US Army, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. [Eliason, Jeffrey K.; Nelson, Keith A.] MIT, Dept Chem, Cambridge, MA 02139 USA. [Hsieh, Alex J.; Nelson, Keith A.; Parsons, Ethan M.] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. RP Hsieh, AJ (reprint author), US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM alex.j.hsieh.civ@mail.mil FU Army Research Laboratory (ARL); U.S. Army through the Institute for Soldier Nanotechnologies (ISN) [W911NF-07-D-0004]; Army Research Office FX AJH and TLC acknowledge funding support from the Army Research Laboratory (ARL) Director's Research Initiative program. AJH, JKE, KAN and EMP also acknowledge collaboration opportunity through funding support by the U.S. Army through the Institute for Soldier Nanotechnologies (ISN), under Contract W911NF-07-D-0004. WH thanks the Army Research Office for funding, also the University of Massachusetts-Amherst Materials Research Science and Engineering Center (MRSEC) and the Materials Research Facilities Network (MRFN) for supporting the use of DSX300 solid-state NMR instrument. AJH acknowledges Dr. Richard C. Becker of ARL for the review and critical comments for this manuscript. AJH also thank Dr. Norm Rice of Triton Systems, Inc. (Chelmsford, MA) for providing PUU materials, through an ISN project funded by the Army. NR 48 TC 3 Z9 3 U1 0 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD APR 1 PY 2014 VL 55 IS 7 BP 1883 EP 1892 DI 10.1016/j.polymer.2014.02.037 PG 10 WC Polymer Science SC Polymer Science GA AF8SB UT WOS:000334984800032 ER PT J AU Cafasso, DE Smith, RR AF Cafasso, Danielle E. Smith, Richard R. TI Symptomatic Cholelithiasis and Functional Disorders of the Biliary Tract SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Gallstones; Cholelithiasis; Biliary colic; Gallbladder dyskinesia; Sphincter of Oddi dysfunction ID IDIOPATHIC RECURRENT PANCREATITIS; CHRONIC ACALCULOUS CHOLECYSTITIS; CHOLESTEROL GALLSTONE DISEASE; ODDI DYSFUNCTION; ENDOSCOPIC SPHINCTEROTOMY; GASTROINTESTINAL DISORDERS; GALLBLADDER-DISEASE; SUSPECTED SPHINCTER; ABDOMINAL-PAIN; UNITED-STATES AB Symptomatic cholelithiasis and functional disorders of the biliary tract present with similar signs and symptoms. The functional disorders of the biliary tract include functional gallbladder disorder, dyskinesia, and the sphincter of Oddi disorders. Although the diagnosis and treatment of symptomatic cholelithiasis are relatively straightforward, the diagnosis and treatment of functional disorders can be much more challenging. Many aspects of the diagnosis and treatment of functional disorders are in need of further study. This article discusses uncomplicated gallstone disease and the functional disorders of the biliary tract to emphasize and update the essential components of diagnosis and management. C1 [Cafasso, Danielle E.; Smith, Richard R.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Cafasso, DE (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM danielle.e.cafasso.mil@mail.mil NR 122 TC 2 Z9 2 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 EI 1558-3171 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2014 VL 94 IS 2 BP 233 EP + DI 10.1016/j.suc.2013.12.001 PG 25 WC Surgery SC Surgery GA AG4WM UT WOS:000335421100005 PM 24679419 ER PT J AU Adams, BL Carter, KK Guo, M Wu, HC Tsao, CY Sintim, HO Valdes, JJ Bentley, WE AF Adams, Bryn L. Carter, Karen K. Guo, Min Wu, Hsuan-Chen Tsao, Chen-Yu Sintim, Herman O. Valdes, James J. Bentley, William E. TI Evolved Quorum Sensing Regulator, LsrR, for Altered Switching Functions SO ACS SYNTHETIC BIOLOGY LA English DT Article DE quorum sensing; cell-to-cell communication; AI-2; directed evolution; switch; biosensor; LsrR ID ESCHERICHIA-COLI K-12; SYNTHETIC BIOLOGY; INTERSPECIES COMMUNICATION; TETRACYCLINE REPRESSORS; SALMONELLA-TYPHIMURIUM; GENE-EXPRESSION; CROSS-TALK; AUTOINDUCER-2; BACTERIA; BIOFILM AB In order to carry out innovative complex, multistep synthetic biology functions, members of a cell population often must communicate with one another to coordinate processes in a programmed manner. It therefore follows that native microbial communication systems are a conspicuous target for developing engineered populations and networks. Quorum sensing (QS) is a highly conserved mechanism of bacterial cell-cell communication communication and QS-based synthetic signal transduction pathways represent a new generation of biotechnology toolbox members. Specifically, the E. coli QS master regulator, LsrR, is uniquely positioned to actuate gene expression in response to a QS signal. In order to expand the use of LsrR in synthetic biology, two novel LsrR switches were generated through directed evolution: an "enhanced" repression and derepression eLsrR and a reversed repression/derepression function "activator" aLsrR. Protein modeling and docking studies are presented to gain insight into the QS signal binding to these two evolved proteins and their newly acquired functionality. We demonstrated the use of the aLsrR switch using a coculture system in which a QS signal, produced by one bacterial strain, is used to inhibit gene expression via aLsrR in a different strain. These first ever AI-2 controlled synthetic switches allow gene expression from the lsr promoter to be tuned simultaneously in two distinct cell populations. This, work expands the tools available to create engineered microbial populations capable of carrying out complex functions necessary for, the development of advanced synthetic products. C1 [Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Adams, Bryn L.; Carter, Karen K.; Wu, Hsuan-Chen; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Guo, Min; Sintim, Herman O.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Adams, Bryn L.; Valdes, James J.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. EM bentley@eng.umd.edu RI Sintim, Herman/B-4475-2009; Guo, Min/D-5989-2016; OI Sintim, Herman/0000-0002-2280-9359; Guo, Min/0000-0003-4632-7116; WU, HSUAN-CHEN/0000-0002-7837-1333 FU Camille Dreyfus foundation; Defense Threat Reduction Agency (DTRA) [BO085PO008]; Office of Naval Research [N000141010446]; National Science Foundation [CBET 1160005]; R. W. Deutsch Foundation FX The authors wish to thank Ms. Shira Cramer, Mr. Karan Raje, and Ms. Chelsea R. Virgile for laboratory technical assistance. The authors also wish to thank Dr. Kyoung-Seok Ryu (Korea Basic Science Institute) for valuable discussions. Funding provided by the Camille Dreyfus foundation (to HOS), the Defense Threat Reduction Agency (DTRA, BO085PO008), the Office of Naval Research (N000141010446), the National Science Foundation (CBET 1160005), and the R. W. Deutsch Foundation. NR 58 TC 7 Z9 7 U1 4 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2161-5063 J9 ACS SYNTH BIOL JI ACS Synth. Biol. PD APR PY 2014 VL 3 IS 4 BP 210 EP 219 DI 10.1021/sb400068z PG 10 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA AF6KF UT WOS:000334823300003 PM 24111753 ER PT J AU Charkoudian, N Stachenfeld, NS AF Charkoudian, Nisha Stachenfeld, Nina S. TI Reproductive Hormone Influences on Thermoregulation in Women SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID SKIN BLOOD-FLOW; GANIRELIX ANTAGON/ORGALUTRAN-ASTERISK; ACTIVE CUTANEOUS VASODILATION; HEALTHY FEMALE VOLUNTEERS; HUMAN MENSTRUAL-CYCLE; UP HERS-II; REFLEX CONTROL; PHARMACODYNAMIC CHARACTERISTICS; ESTROGEN/PROGESTIN REPLACEMENT; THERMOEFFECTOR RESPONSES AB The present discussion reviews current knowledge regarding influences of the primary reproductive hormones on mechanisms of thermoregulatory control in women. The human body is remarkably capable of maintaining body temperature within a few tenths of a degree of normal (37 degrees C) over a wide range of activity and environmental exposures; this regulation is accomplished via integration of central and peripheral thermal information at the preoptic area of the anterior hypothalamus (PO/AH). We describe both central and peripheral mechanisms involved in controlling thermoregulation in humans, and how these mechanisms are affected by sex and hormone exposure. Estrogens generally promote vasodilation, heat dissipation, and lower body temperature and progesterone or progestins generally have the opposite effect. Estrogens and progesterone/progestins can also interact with androgens; this is an important point because androgens in the body can increase in both older and younger women. The study of reproductive hormone (estrogens, progesterone, luteinizing, and follicle stimulating hormones) effects on body systems is challenging because of the complex and multifaceted influences of these hormones, both individually and in combination. Thus, a number of methods to alter hormone exposure are explained in this article. We conclude that men and women do not exhibit major quantitative differences in physiological thermoregulatory responses to exercise and/or body heating when factors such as fitness and body size are taken into account. However, female and male reproductive hormones have important influences that can significantly alter individual thermoregulatory responses at various points throughout the lifespan. C1 [Charkoudian, Nisha] US Army Res Inst Environm Med, Natick, MA USA. [Stachenfeld, Nina S.] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA. [Stachenfeld, Nina S.] Yale Univ, Sch Med, Sch Publ Hlth, New Haven, CT USA. [Stachenfeld, Nina S.] John B Pierce Lab, New Haven, CT USA. RP Stachenfeld, NS (reprint author), Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA. EM nstach@jbpierce.org NR 75 TC 8 Z9 8 U1 3 U2 37 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD APR PY 2014 VL 4 IS 2 BP 793 EP 804 DI 10.1002/cphy.c130029 PG 12 WC Physiology SC Physiology GA AE9SP UT WOS:000334350100009 PM 24715568 ER PT J AU Charkoudian, N Wallin, BG AF Charkoudian, N. Wallin, B. G. TI Sympathetic Neural Activity to the Cardiovascular System: Integrator of Systemic Physiology and Interindividual Characteristics SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID LONG-TERM CONTROL; SPONTANEOUSLY HYPERTENSIVE-RATS; ARTERIAL-PRESSURE REGULATION; OBSTRUCTIVE SLEEP-APNEA; HUMAN MUSCLE NERVES; FUTURE BLOOD-PRESSURE; CHRONIC INTERMITTENT HYPOXIA; CURRENT COMPUTATIONAL MODELS; RANDOMIZED CONTROLLED-TRIAL; CHRONIC RENAL-HYPERTENSION AB The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascular function with a focus on integrative mechanisms in humans. Direct measurement of sympathetic neural activity (SNA) in humans can be accomplished using microneurography, most commonly performed in the peroneal (fibular) nerve. In humans, muscle SNA (MSNA) is composed of vasoconstrictor fibers; its best-recognized characteristic is its participation in transient, moment-to-moment control of arterial blood pressure via the arterial baroreflex. This property of MSNA contributes to its typical "bursting" pattern which is strongly linked to the cardiac cycle. Recent evidence suggests that sympathetic neural mechanisms and the baroreflex have important roles in the long term control of blood pressure as well. One of the striking characteristics of MSNA is its large interindividual variability. However, in young, normotensive humans, higher MSNA is not linked to higher blood pressure due to balancing influences of other cardiovascular variables. In men, an inverse relationship between MSNA and cardiac output is a major factor in this balance, whereas in women, beta-adrenergic vasodilation offsets the vasoconstrictor/pressor effects of higher MSNA. As people get older (and in people with hypertension) higher MSNA is more likely to be linked to higher blood pressure. Skin SNA (SSNA) can also be measured in humans, although interpretation of SSNA signals is complicated by multiple types of neurons involved (vasoconstrictor, vasodilator, sudomotor and pilomotor). In addition to blood pressure regulation, the sympathetic nervous system contributes to cardiovascular regulation during numerous other reflexes, including those involved in exercise, thermoregulation, chemoreflex regulation, and responses to mental stress. C1 [Charkoudian, N.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Wallin, B. G.] Gothenburg Univ, Inst Neurosci & Physiol, Sahlgren Acad, Gothenburg, Sweden. RP Charkoudian, N (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. EM nisha.charkoudian.civ@mail.mil NR 280 TC 12 Z9 12 U1 1 U2 16 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD APR PY 2014 VL 4 IS 2 BP 827 EP 850 DI 10.1002/cphy.c130038 PG 24 WC Physiology SC Physiology GA AE9SP UT WOS:000334350100011 ER PT J AU McMichael, IT Zaghloul, AI Mirotznik, MS AF McMichael, Ian T. Zaghloul, Amir I. Mirotznik, Mark S. TI Annular Slot Loaded High-Impedance Ground Plane SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE High-impedance ground plane; low-profile antenna ID ANTENNA AB High-impedance surfaces like electromagnetic band gap (EBG) ground planes have been used to realize low profile antennas. In this paper, an alternative ground plane design is presented for antennas with circular current distributions, which consists of an annular slot backed by a thin grounded substrate. The slot ring generates a high-impedance condition at a resonant frequency in the vicinity of the slot. This annular slot loaded ground plane results in efficient radiation of the low profile antenna in the broadside direction. Since the slot loaded ground plane consists of a single slot ring rather than periodic structures, it is much simpler to construct than the standard EBG ground plane. Numerical simulations and experimental measurements are shown to validate the design concept and are compared with a mushroom-type EBG ground plane. A parametric analysis was also conducted by varying the slot ring's dimensions and tuning varactors are shown to vary the ground plane's resonant frequency. C1 [McMichael, Ian T.] Univ Delaware, Newark, DE 19716 USA. [McMichael, Ian T.] US Army CERDEC RDECOM NVESD, Ft Belvoir, VA 22060 USA. [Zaghloul, Amir I.] Army Res Lab, Adelphi, MD 20783 USA. [Mirotznik, Mark S.] Univ Delaware, Elect & Comp Engn Dept, Newark, DE 19716 USA. RP McMichael, IT (reprint author), Univ Delaware, Newark, DE 19716 USA. EM mirotzni@ece.udel.edu NR 7 TC 0 Z9 0 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD APR PY 2014 VL 62 IS 4 BP 2063 EP 2070 DI 10.1109/TAP.2014.2298885 PN 2 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AF5HN UT WOS:000334744700030 ER PT J AU Carpenter, MT Sidow, SJ Lindsey, KW Chuang, A McPherson, JC AF Carpenter, Matthew T. Sidow, Stephanie J. Lindsey, Kimberly W. Chuang, Augustine McPherson, James C., III TI Regaining Apical Patency after Obturation with Gutta-percha and a Sealer Containing Mineral Trioxide Aggregate SO JOURNAL OF ENDODONTICS LA English DT Article DE Mineral trioxide aggregate; MTA Fillapex; patency; retreatment; sealer; solvent ID ROOT-CANAL SEALER; RESORCINOL-FORMALIN PASTE; ENDODONTIC RETREATMENT; REINSTRUMENTATION; SOLVENTS; CHLOROFORM AB Introduction: MTA Fillapex (Angelus Solucoes Odontologicas, Londrina PR, Brazil) was introduced as a mineral trioxide aggregate (MTA)-based sealer used for endodontic obturation. There is a lack of research that evaluates the ability of different solvents to soften MTA-based sealers during retreatment. This study tested the ability of 4 commonly used endodontic solvents to soften gutta-percha and MTA Fillapex to allow for the re-establishment of apical patency. Methods: Eighty-six extracted maxillary anterior teeth were instrumented to the working length to a size 45 (.04 taper size). Teeth were divided into 2 groups (n = 43 for each group). MTA Fillapex was placed into all canals. Group 1 was obturated with gutta-percha to the working length, and group 2 was obturated 2 mm short of the working length to ensure the apical 2 mm was filled with sealer only. Both groups were divided into 4 subgroups (n = 10). The remaining teeth served as the control group. Each subgroup was exposed to 1 of the following solvents: chloroform; Endosolv R (Septodont, Saint-Maur, France), Endosolv E (Septodont), or eucalyptol. Results: Patency was re-established in 100% of the teeth in groups 1 and,2 when tested with chloroform or Endosolv E, 80% of the teeth in group 1 and 90% in group 2 when tested with eucalyptol, and 10% of the teeth in group 1 and 50% in group 2 tested when with Endosolv R. The chi-square test indicated there was a statistical difference between Endosolv R and the other tested solvents for both groups. Conclusions: Chloroform, Endosolv E, and Eucalyptol soften GP and MTA Fillapex sufficiently to aid in re-establishing apical patency during endodontic retreatment. C1 [Carpenter, Matthew T.; Sidow, Stephanie J.; Lindsey, Kimberly W.] US Army, Dent Activ, Ft Gordon, GA 30905 USA. [Chuang, Augustine; McPherson, James C., III] Dept Clin Invest, Ft Gordon, GA USA. RP Sidow, SJ (reprint author), US Army, Dent Activ, Dept Endodont, Ft Gordon, GA 30905 USA. EM stephanie.j.sidow.mil@mail.mil NR 20 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 EI 1878-3554 J9 J ENDODONT JI J. Endod. PD APR PY 2014 VL 40 IS 4 BP 588 EP 590 DI 10.1016/j.joen.2013.10.020 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AF3YA UT WOS:000334647400026 PM 24666918 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI Defender of Canada: Sir George Prevost and the War of 1812 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Barbuto, Richard V.] US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. RP Barbuto, RV (reprint author), US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2014 VL 78 IS 2 BP 782 EP 783 PG 2 WC History SC History GA AE7CK UT WOS:000334154100032 ER PT J AU Hull, MM AF Hull, Mark M. TI Northern Ireland in the Second World War: Politics, Economic Mobilization and Sodety, 1939-45. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Hull, Mark M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Hull, MM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2014 VL 78 IS 2 BP 819 EP 821 PG 3 WC History SC History GA AE7CK UT WOS:000334154100058 ER PT J AU Nowowiejski, D AF Nowowiejski, Dean TI Strangers in the Wild Place: Refugees, Americans, and a German Town, 1945-1952 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Nowowiejski, Dean] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Nowowiejski, D (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2014 VL 78 IS 2 BP 838 EP 839 PG 2 WC History SC History GA AE7CK UT WOS:000334154100071 ER PT J AU Hamilton, RJ Morilla, D Cabrera, F Leapman, M Chen, LY Bernstein, M Hakimi, AA Reuter, VE Russo, P AF Hamilton, Robert J. Morilla, Daniel Cabrera, Fernando Leapman, Michael Chen, Ling Y. Bernstein, Melanie Hakimi, A. Ari Reuter, Victor E. Russo, Paul TI The Association between Statin Medication and Progression after Surgery for Localized Renal Cell Carcinoma SO JOURNAL OF UROLOGY LA English DT Article DE kidney neoplasms; hydroxymethylglutaryl-CoA reductase inhibitors; nephrectomy; disease progression; chemoprevention ID BREAST-CANCER RECURRENCE; PROSTATE-CANCER; RADICAL PROSTATECTOMY; BIOCHEMICAL RECURRENCE; PROSPECTIVE COHORT; RISK; METAANALYSIS; DATABASE; MEN AB Purpose: Evidence suggests that statins may influence pathways of renal cell carcinoma proliferation, although to our knowledge no study has examined the influence of statin medications on the progression of renal cell carcinoma in humans. Materials and Methods: We identified 2,608 patients with localized renal cell carcinoma who were treated surgically between 1995 and 2010 at our tertiary referral center. Competing risks Cox proportional hazards models were used to evaluate the relationship between statin use and time to local recurrence or progression (metastases or death from renal cell carcinoma) and overall survival. Statin use was modeled as a time dependent covariate as a sensitivity analysis. Models were adjusted for clinical and demographic features. Results: Of 2,608 patients 699 (27%) were statin users at surgery. Statin users had similar pathological characteristics compared to nonusers. At a median followup of 36 months there were 247 progression events. Statin use was associated with a 33% reduction in the risk of progression after surgery (HR 0.67, 95% CI 0.47-0.96, p = 0.028) and an 11% reduction in overall mortality that was not significant (HR 0.89, 95% CI 0.71-1.13, p = 0.3). Modeling statin use as a time dependent covariate attenuated the risk reduction in progression to 23% (HR 0.77, p = 0.12) and augmented the risk reduction in overall survival (HR 0.71, p = 0.002). Conclusions: In our cohort statin use was associated with a reduced risk of progression and overall mortality, although this effect was sensitive to the method of analysis. If validated in other cohorts, this finding warrants consideration of prospective research on statins in the adjuvant setting. C1 [Hamilton, Robert J.; Bernstein, Melanie; Hakimi, A. Ari; Russo, Paul] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA. [Chen, Ling Y.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA. [Reuter, Victor E.] Mem Sloan Kettering Canc Ctr, Dept Pathol, Surg Pathol Diagnost Serv, New York, NY 10065 USA. [Cabrera, Fernando] Suny Downstate Med Ctr, Dept Urol, New York, NY USA. [Leapman, Michael] Mt Sinai Med Ctr, Dept Urol, New York, NY 10029 USA. [Hamilton, Robert J.] Univ Toronto, Dept Surg, Div Urol, Toronto, ON, Canada. [Morilla, Daniel] Tripler Army Med Ctr, Urol Serv, Honolulu, HI 96859 USA. RP Russo, P (reprint author), Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA. EM russop@mskcc.org OI Hamilton, Robert/0000-0002-6715-5934; Bernstein, Melanie/0000-0002-0681-6188 FU Steven Hanson Family Kidney Cancer Research Fund FX Supported by the Steven Hanson Family Kidney Cancer Research Fund. NR 27 TC 15 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD APR PY 2014 VL 191 IS 4 BP 914 EP 919 DI 10.1016/j.juro.2013.10.141 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA AF5OP UT WOS:000334763100010 PM 24291547 ER PT J AU Malinovsky, VS Rudin, S AF Malinovsky, Vladimir S. Rudin, Sergey TI Adiabatic holonomic quantum gates for a single qubit SO PHYSICA SCRIPTA LA English DT Article; Proceedings Paper CT 20th Central European Workshop on Quantum Optics CY JUN 16-20, 2013 CL Stockholm, SWEDEN DE holonomic quantum gates; geometric phase; adiabatic dynamics ID PHASE; COMPUTATION AB A universal set of single qubit holonomic quantum gates using the geometric phase that the qubit wave function acquires after a cyclic evolution is discussed. The proposed scheme utilizes ultrafast linearly chirped pulses and provides a possibility to substantially suppress transient population of the ancillary state in a generic three-level system. That provides a possibility to reduce the decoherence effect and achieve a higher fidelity of the quantum gates. C1 [Malinovsky, Vladimir S.; Rudin, Sergey] US Army Res Lab, Adelphi, MD 20783 USA. RP Malinovsky, VS (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM vsmalinovsky@gmail.com NR 25 TC 1 Z9 1 U1 1 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-8949 EI 1402-4896 J9 PHYS SCRIPTA JI Phys. Scr. PD APR PY 2014 VL T160 AR 014029 DI 10.1088/0031-8949/2014/T160/014029 PG 4 WC Physics, Multidisciplinary SC Physics GA AG2CY UT WOS:000335224700030 ER PT J AU Cuddy, MF Poda, AR Chappell, MA AF Cuddy, Michael F. Poda, Aimee R. Chappell, Mark A. TI Estimations of Vapor Pressures by Thermogravimetric Analysis of the Insensitive Munitions IMX-101, IMX-104, and Individual Components SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE IMX-101; IMX-104; Vapor pressure; Langmuir equation; Clausius-Clapeyron ID MELTING-POINT; EXPLOSIVES; DECOMPOSITION; SUBLIMATION; VAPORIZATION; MODEL; RDX AB We have calculated the vapor pressures of the new explosives ordnances IMX-101 and IMX-104 and their respective components, 2,4-dinitroanisole (DNAN), nitroguanidine (NQ), nitrotriazolone (NTO), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by the method of rising temperature thermogravimetric analysis. Clausius-Clapeyron relationships were assumed for each case and the vapor pressures were estimated from the Langmuir equation over an appropriate temperature range just below substance melting/decomposition points. For vapor pressures extrapolated to room temperature, the rank with respect to decreasing volatility was found to be: DNAN>IMX-104>IMX-101>NQ>RDX>NTO. Interestingly, vapor pressure depression is observed in IMX formulations, where the formulation has a lower vapor pressure than its most volatile component, DNAN. The enthalpy of sublimation was determined for each substance and formulation from Clausius-Clapeyron equations generated by analysis of the thermogravimetric data. The general trends in vapor pressures and sublimation enthalpies associated with the component materials were in good agreement with previous experimental and computational results. The results obtained by this study have importance for future investigations of IMX, specifically for chemical detection and assessment of environmental fate. C1 [Cuddy, Michael F.; Poda, Aimee R.; Chappell, Mark A.] US Army Corps Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Cuddy, MF (reprint author), US Army Corps Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM michael.cuddy@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 25 TC 5 Z9 6 U1 2 U2 20 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD APR PY 2014 VL 39 IS 2 BP 236 EP 242 DI 10.1002/prep.201300069 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA AF3LE UT WOS:000334613000013 ER PT J AU Walsh, MR Walsh, ME Ramsey, CA Thiboutot, S Ampleman, G Diaz, E Zufelt, JE AF Walsh, Michael R. Walsh, Marianne E. Ramsey, Charles A. Thiboutot, Sonia Ampleman, Guy Diaz, Emmanuela Zufelt, Jon E. TI Energetic Residues from the Detonation of IMX-104 Insensitive Munitions SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Insensitive munitions; Detonation residues; IMX-104; NTO; Environment ID DEPOSITION RATES AB The development of insensitive munitions by NATO countries is an ongoing effort. Less-sensitive ingredients in both explosives and propellants will ensure the protection of deployed troops against an unwanted reaction to an external stimulus on the munitions stockpile. In the US Army, current efforts are directed towards the development of melt cast insensitive explosive formulations. Various formulations, mainly based on DNAN and NTO, have been developed and are now being fielded. Our research goal is to measure the deposition rate of energetics compounds from various insensitive munitions detonation scenarios. Our hypothesis is that the relative insensitiveness of these formulations leads to slightly higher deposition rates than conventional explosive formulations. This paper describes detonation residues research on mortar rounds containing IMX-104 explosive. Analyses indicate that high-order detonation residues are slightly greater for this formulation than for conventional munitions. However, blow-in-place detonations (BIPs) resulted in much higher residues deposition, indicating that a larger donor charge is required for efficient detonation. The highly soluble compound NTO was particularly problematic, with BIP deposition approaching 95% of the original load. Toxicological studies of NTO are not finalized, leaving considerable uncertainty regarding the feasibility of approving these rounds for distribution. C1 [Walsh, Michael R.; Walsh, Marianne E.; Zufelt, Jon E.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ramsey, Charles A.] Envirostat INC, Ft Collins, CO 80522 USA. [Thiboutot, Sonia; Ampleman, Guy; Diaz, Emmanuela] Def Res & Dev Canada Valcartier, Val Belair, PQ G3J 1X5, Canada. RP Walsh, MR (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil NR 17 TC 6 Z9 6 U1 0 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD APR PY 2014 VL 39 IS 2 BP 243 EP 250 DI 10.1002/prep.201300095 PG 8 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA AF3LE UT WOS:000334613000014 ER PT J AU Roberts, CM Inniss, EC AF Roberts, C. M. Inniss, E. C. TI Implementing Treatment Sequences to Promote Reduction of DBPs in Small Drinking Water Systems SO WATER RESOURCES MANAGEMENT LA English DT Article DE Disinfection by-products; Enhanced coagulation/softening; Haloacetic acid; Trihalomethane; Formation potential ID HALOACETIC ACIDS; REMOVAL; CHLORINATION; COAGULATION AB The performance of three drinking water treatment sequences found in small community systems in reducing disinfection by-product precursor concentrations and the corresponding disinfection by-product formation potential was evaluated. Raw water quality and its potential for effective removal were characterized by the specific ultraviolet absorbance (SUVA) components of absorbance of ultraviolet light at 254 nm wavelength (UV254) and dissolved organic carbon (DOC). The results demonstrate that, for the source water qualities tested (hydrophobic SUVA with moderate DOC content, 2.0 to 4.8 L/(mg.m) and 4.1 to 6.3 mg DOC/L), there was a tendency to produce a higher percentage of total trihalomethane (TTHM) over the five regulated species of haloacetic acid (HAA5). The treatment sequence and chemical selection play a critical role in the ability of a small community system operator to achieve compliance with the concentration of regulated disinfection by-products. For the waters tested ferric chloride coagulants perform better at reducing the higher molecular weight, hydrophobic organic precursors. Powdered activated carbon does not perform as well with these source waters unless its application is followed by a clarification process that effectively forms a sludge blanket. This research provides additional criteria for linking source water quality with treatment sequence for sustainable management of disinfection by-product (DBP) compliance. C1 [Roberts, C. M.] US Army Corps Engn, Kansas City, MO 64106 USA. [Inniss, E. C.] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. RP Inniss, EC (reprint author), Univ Missouri, Dept Civil & Environm Engn, E2509 Lafferre Hall, Columbia, MO 65211 USA. EM innisse@missouri.edu FU former Missouri Technical Assistance Center, part of the University of Missouri Water Resources Research Center (WRRC) FX This research was partially funded through the former Missouri Technical Assistance Center that was part of the University of Missouri Water Resources Research Center (WRRC) and partially funded by each of the community partners. We thank Dr. Thomas Clevenger, director of WRRC, for access to space and equipment, Dr. Jing Cheng for analysis of water samples for Phase 1 of this project, Mr. Daniel Crosby for his assistance with gathering water samples from each of the facilities, Dr. Robert Reed for his assistance with coordinating with the partner communities, Mr. Roger Sullivan of Marceline, MO for his assistance with the jar testing and treatment strategy guidance, Mr. Steve Reid of Trenton, MO, Mr. Donnie Parsons of Monroe City, and Mr. Larry Howertor of Monroe City for their assistance with sample collection and treatment strategy guidance. NR 26 TC 1 Z9 1 U1 2 U2 22 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-4741 EI 1573-1650 J9 WATER RESOUR MANAG JI Water Resour. Manag. PD APR PY 2014 VL 28 IS 6 BP 1631 EP 1643 DI 10.1007/s11269-014-0570-x PG 13 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AE7NM UT WOS:000334184800010 ER PT J AU Recchia, S Zheng, J Pelegri, AA AF Recchia, Stephen Zheng, James Pelegri, Assimina A. TI Fiberwalk: a random walk approach to fiber representative volume element creation SO ACTA MECHANICA LA English DT Article; Proceedings Paper CT Prager Medal Symposium in honor of George Weng CY JUL 28-31, 2013 CL Providence, RI SP Soc Engn Sci, Brown Univ, ASME, Appl Mech Div ID PACKING ALGORITHM; PARTICLES; COMPOSITES; MODEL AB Attaining accurate representative geometry for a finite element analysis at various scales can be a challenging research task. Added complications arise when the geometry is representing a manufactured or biological composite. In this study, a representative geometry of linear fibrous composites was created at the microscale and is employed to reproduce crystalline microfibril stacking of Kevlar to form a single fibril joined by a non-ordered crystal structure. The structure can have ellipsoidal or rectangular microfibrils stacked in ellipsoidal or rectangular fibrils and may have any desired packing ratio within the 1-100% range. In order to build a fibrous structure along a path, a Random Walk methodology was used. Since the directionality of the fibers is random, but always stepping from one side of the path toward the other, the fibers can wind around each other and tangle or terminate if needed. Another key concept of this method is the addition of a rotation matrix operation for the path of the fibers. This allows the path around the three local coordinates to be in a linear or sinusoidal direction. The resultant geometry produced can represent the tortuous path nanofibrils undergo. Moreover, rotation about the path axis allows for the twisted geometry of ring spun yarn, and metal cable to be reproduced. Inclusion of spherical objects to the path of the fibers has been accommodated to reproduce fiber projection around, or end at, an obstruction in their path. This approach allows representing impurities at the fibril, fiber, or yarn level of composite fabric manufacturing. C1 [Recchia, Stephen] Rutgers State Univ, Sch Engn, Adv Mat Struct Lab, Piscataway, NJ 08854 USA. [Zheng, James] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. [Pelegri, Assimina A.] Rutgers State Univ, Sch Engn, Piscataway, NJ 08854 USA. RP Pelegri, AA (reprint author), Rutgers State Univ, Sch Engn, 98 Brett Rd, Piscataway, NJ 08854 USA. EM pelegri@jove.rutgers.edu NR 36 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0001-5970 EI 1619-6937 J9 ACTA MECH JI Acta Mech. PD APR PY 2014 VL 225 IS 4-5 SI SI BP 1301 EP 1312 DI 10.1007/s00707-013-1069-x PG 12 WC Mechanics SC Mechanics GA AE6PD UT WOS:000334115100025 ER PT J AU Lesho, E Okito, EA Mann, K McCullough, M Hesse, E AF Lesho, Emil Okito, Edmond Amisi Mann, Kelly McCullough, Michael Hesse, Elisabeth TI Short Report: Collaborative Medical Engagement and Needs Assessment in the Democratic Republic of the Congo: A Preliminary Report from Muanda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB The Democratic Republic of the Congo is the second largest and fourth most populous country in Africa. More than two decades of ongoing conflicts have degraded its healthcare system. A broad range of tropical diseases, along with opportunities for collaborative medical engagements (CMEs), are prevalent. However, reports from such events in this country are sparse. In June 2013, a CME was conducted in the western town of Muanda. Twenty-two hours of didactic sessions were collaboratively presented, and 158 patients were collaboratively evaluated. Durable dental and respiratory equipment, infrastructure improvements, and training opportunities were the top needs identified by the providers. Whether the regional referral hospital received sustainable benefit remains under investigation. However, the approach and needs assessment described herein provide a framework for future engagements or assistance. This CME established a precedence of medical partnership in the region because it led to the largest multidisciplinary joint collaboration in the history of the Democratic Republic of the Congo. C1 [Lesho, Emil] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Okito, Edmond Amisi] Hosp Mil Reference Muanda, Armees Republ Democrat Congo, Muanda Mil Base, Muanda, Congo. Tripler Army Med Ctr, Honolulu, HI 96859 USA. US Embassy, Off Secur Cooperat, Kinshasa, Kinshasha, Congo. [Hesse, Elisabeth] 82nd Civil Affairs Battal, Ft Stewart, GA USA. [Mann, Kelly] Tripler Army Med Ctr, Dept Infect Dis, Honolulu, HI 96859 USA. [McCullough, Michael] US Embassy Kinshasa, Off Secur Cooperat, Kinshasa, Congo. RP Lesho, E (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com; okitoamisi@yahoo.fr; kelley.m.mann5.mil@mail.mil; mcculloughms@state.gov; elisabeth.m.hesse.mil@mail.mil NR 7 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2014 VL 90 IS 4 BP 774 EP 776 DI 10.4269/ajtmh.13-0528 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AE6HS UT WOS:000334091800034 PM 24534813 ER PT J AU Kalb, SR Baudys, J Smith, TJ Smith, LA Barr, JR AF Kalb, Suzanne R. Baudys, Jakub Smith, Theresa J. Smith, Leonard A. Barr, John R. TI Three Enzymatically Active Neurotoxins of Clostridium botulinum Strain Af84: BoNT/A2, /F4, and /F5 SO ANALYTICAL CHEMISTRY LA English DT Article ID TOXIN PROTEOMICS; ENDOPEP-MS; SEROTYPE-A; SNAP-25; IDENTIFICATION; CLEAVAGE; GROWTH; PH; VAMP/SYNAPTOBREVIN; PROTEOLYSIS AB Botulinum neurotoxins (BoNTs) are produced by various species of clostridia and are potent neurotoxins which cause the disease botulism, by cleaving proteins needed for successful nerve transmission. There are currently seven confirmed serotypes of BoNTs, labeled A-G, and toxin-producing clostridia typically only produce one serotype of BoNT. There are a few strains (bivalent strains) which are known to produce more than one serotype of BoNT, producing either both BoNT/A and /B, BoNT/A and /F, or BoNT/B and /F, designated as Ab, Ba, Af, or BE Recently, it was reported that Clostridium botulinum strain Af84 has three neurotoxin gene clusters: bont/A2, bont/F4, and bont/F5. This was the first report of a clostridial organism containing more than two neurotoxin gene clusters. Using a mass spectrometry based proteomics approach, we report here that all three neurotoxins, BoNT/A2, /F4, and /F5, are produced by C. botulinum Af84. Label free MSE quantification of the three toxins indicated that toxin composition is 88% BoNT/A2, 1% BoNT/F4, and 11% BoNT/F5. The enzymatic activity of all three neurotoxins was assessed by examining the enzymatic activity of the neurotoxins upon peptide substrates, which mimic the toxins' natural targets, and monitoring cleavage of the substrates by mass spectrometry. We determined that all three neurotoxins are enzymatically active. This is the first report of three enzymatically active neurotoxins produced in a single strain of Clostridium botulinum. C1 [Kalb, Suzanne R.; Baudys, Jakub; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Smith, Theresa J.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] Med Res & Mat Command, Off Chief Scientist, Ft Detrick, MD 21702 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy, Atlanta, GA 30341 USA. EM jbarr@cdc.gov OI Kalb, Suzanne/0000-0002-8067-136X FU Intramural CDC HHS [CC999999] NR 30 TC 10 Z9 10 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD APR 1 PY 2014 VL 86 IS 7 BP 3254 EP 3262 DI 10.1021/ac5001509 PG 9 WC Chemistry, Analytical SC Chemistry GA AE2AV UT WOS:000333776600003 PM 24605815 ER PT J AU Sherman, WE Rizzo, JA Arciero, CA AF Sherman, William E. Rizzo, Julie A. Arciero, Cletus A. TI Breast Conservation vs Mastectomy for Early-Stage Breast Cancer: How Does the Department of Defense Compare? SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 15th Annual Meeting of the American-Society-of-Breast-Surgeons CY APR 30-MAY 04, 2014 CL Las Vegas, NV SP Amer Soc Breast Surg C1 [Sherman, William E.; Rizzo, Julie A.; Arciero, Cletus A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 EI 1534-4681 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD APR PY 2014 VL 21 SU 2 BP 109 EP 109 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA AE7XC UT WOS:000334211800133 ER PT J AU Chung, KK Dubick, MA AF Chung, Kevin K. Dubick, Michael A. TI Building the Case Toward a Definitive Clinical Trial: Saline Versus Plasma-Lyte* SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE acute kidney injury; fluid resuscitation; normal saline; Plasma-Lyte; sepsis ID ACUTE KIDNEY INJURY; RENAL BLOOD-FLOW; 0.9-PERCENT SALINE; SEPSIS; RESUSCITATION; CHLORIDE C1 [Chung, Kevin K.] US Army, Inst Surg Res, San Antonio, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Dubick, Michael A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Dubick, Michael A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), US Army, Inst Surg Res, San Antonio, TX 78234 USA. NR 11 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD APR PY 2014 VL 42 IS 4 BP 1009 EP 1010 DI 10.1097/CCM.0000000000000194 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA AC9FL UT WOS:000332839700063 PM 24633112 ER PT J AU Hoedebecke, K Rerucha, C Runser, L AF Hoedebecke, Kyle Rerucha, Caitlyn Runser, Lloyd TI Increase in Residency Scholarly Activity as a Result of Resident-Led Initiative SO FAMILY MEDICINE LA English DT Article ID PROGRAMS AB BACKGROUND AND OBJECTIVES: Scholarly activity (SA) is a fundamental component of family medicine residency training. Despite the variety of SA options, the output of resident presentations and publications remains disappointingly low, and many residents voice frustration with fulfilling the research requirements. A resident-driven process improvement project was undertaken with the goal of achieving a 100% increase of peer-reviewed publications and scholarly presentations by residents with secondary goals of doubling the involvement of staff, residents, and visiting medical or physician assistant students. METHODS: This project involves (1) increasing awareness of conferences for scholarly submission, (2) assignment of residents in a resident research team to lead efforts, (3) pairing of interns/students with senior mentors with similar interests, (4) faculty to include one resident on all projects, and (5) monthly SA meetings to track research progress, share ideas, and troubleshoot areas of difficulty. Scholarly totals were compared between the 2011-2012 and 2012-2013 academic years. RESULTS: The SA goals were achieved on all fronts. The number of resident presentations increased from three to 28 (seven regional, 10 national, and 11 international presentations), and resident peer-reviewed publications increased from two to six when compared to the previous year. Scholarly participation doubled at all levels. CONCLUSIONS: The authors recommend that other residencies consider promoting increased resident-to-resident scholarly mentorship, early planning with scheduled timeline, and increasing awareness of SA opportunities yearly. C1 [Hoedebecke, Kyle; Rerucha, Caitlyn; Runser, Lloyd] Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28310 USA. RP Hoedebecke, K (reprint author), Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28310 USA. EM Kyle.L.Hoedebecke.mil@mail.mil NR 11 TC 2 Z9 2 U1 0 U2 1 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD APR PY 2014 VL 46 IS 4 BP 288 EP 290 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AE7CE UT WOS:000334153500007 PM 24788425 ER PT J AU Tompkins, RP Smith, JR Kirchner, KW Jones, KA Leach, JH Udwary, K Preble, E Suvarna, P Leathersich, JM Shahedipour-Sandvik, F AF Tompkins, R. P. Smith, J. R. Kirchner, K. W. Jones, K. A. Leach, J. H. Udwary, K. Preble, E. Suvarna, P. Leathersich, J. M. Shahedipour-Sandvik, F. TI GaN Power Schottky Diodes with Drift Layers Grown on Four Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Schottky diode; gallium nitride; high-power electronics; ammonothermal ID BULK AMMONOTHERMAL GAN; VAPOR-PHASE EPITAXY; FREESTANDING GAN; YELLOW LUMINESCENCE; SCREW DISLOCATIONS; GALLIUM VACANCIES; CARBON; RECTIFIERS; HVPE; GAAS AB We have examined the performance of gallium nitride (GaN) high-power Schottky diodes fabricated on unintentionally doped (UID) metalorganic chemical vapor deposition (MOCVD) films grown simultaneously on four substrates ranging in threading dislocation density from 5 x 10(3) cm (- 2) to 10(10) cm (- 2). The substrates were an intentionally doped and a UID freestanding hydride vapor phase epitaxy substrate, an MOCVD GaN template grown on a sapphire wafer, and a bulk GaN substrate grown via an ammonothermal method. Capacitance-voltage (C-V) results showed the carrier concentration was similar to 2 x 10(16) cm(-3) for films grown on each of the four substrates. With that doping level, the theoretical breakdown voltage (V (b)) is similar to 1600 V. However, measured V (b) for the devices tested on each of the four substrates fell short of this value. Also, the breakdown voltages across each of the four substrates were not substantially different. This result was especially surprising for films grown on bulk GaN substrates, because of their superior crystal quality, as determined from their x-ray rocking curve widths. Simple probability calculations showed that most of the diodes tested on the bulk substrate did not cover a single threading dislocation. Although optimization of edge-termination schemes is likely to improve V (b), we believe that point defects, not threading dislocations, are the main reason for the reduced performance of these devices. C1 [Tompkins, R. P.; Smith, J. R.; Kirchner, K. W.; Jones, K. A.] US Army Res Lab, Adelphi, MD 20783 USA. [Tompkins, R. P.] Gen Tech Serv, Wall, NJ 07719 USA. [Leach, J. H.; Udwary, K.; Preble, E.] Kyma Technol, Raleigh, NC 27617 USA. [Suvarna, P.; Leathersich, J. M.; Shahedipour-Sandvik, F.] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. RP Tompkins, RP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM randy.tompkins.ctr@mail.mil OI Smith, Joshua/0000-0002-3137-7180 NR 33 TC 4 Z9 4 U1 5 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD APR PY 2014 VL 43 IS 4 BP 850 EP 856 DI 10.1007/s11664-014-3021-9 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AE7MR UT WOS:000334182700008 ER PT J AU Lefkowitz, W Jefferson, TC AF Lefkowitz, W. Jefferson, T. C. TI Medicine at the limits of evidence: the fundamental limitation of the randomized clinical trial and the end of equipoise SO JOURNAL OF PERINATOLOGY LA English DT Editorial Material ID EXTREMELY PRETERM INFANTS; OXYGEN-SATURATION; OUTCOMES C1 [Lefkowitz, W.; Jefferson, T. C.] Brooke Army Med Ctr, Dept Pediat MCHE DPN, Houston, TX 78234 USA. RP Lefkowitz, W (reprint author), Brooke Army Med Ctr, Dept Pediat MCHE DPN, Houston, TX 78234 USA. EM william.lefkowitz.mil@mail.mil NR 12 TC 1 Z9 1 U1 2 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 EI 1476-5543 J9 J PERINATOL JI J. Perinatol. PD APR PY 2014 VL 34 IS 4 BP 249 EP 251 DI 10.1038/jp.2013.172 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA AE2PA UT WOS:000333814200001 PM 24675017 ER PT J AU Grande, R Nistico, L Sambanthamoorthy, K Longwell, M Iannitelli, A Cellini, L Di Stefano, A Stoodley, LH Stoodley, P AF Grande, Rossella Nistico, Laura Sambanthamoorthy, Karthik Longwell, Mark Iannitelli, Antonio Cellini, Luigina Di Stefano, Antonio Stoodley, Luanne Hall Stoodley, Paul TI Temporal expression of agrB, cidA, and alsS in the early development of Staphylococcus aureus UAMS-1 biofilm formation and the structural role of extracellular DNA and carbohydrates SO PATHOGENS AND DISEASE LA English DT Article DE biofilm; Staphylococcus aureus; agrB; alsS; cidA; eDNA; carbohydrate ID GENE REGULATOR AGR; STREPTOCOCCUS-PNEUMONIAE; MEMBRANE-VESICLES; VIRULENCE FACTORS; ACETOIN; RELEASE; SURFACE; ACID; PH; POLYSACCHARIDE AB Extracellular DNA (eDNA) is an important component of the extracellular polymeric substance matrix and is important in the establishment and persistence of Staphylococcus aureus UAMS-1 biofilms. The aim of the study was to determine the temporal expression of genes involved in early biofilm formation and eDNA production. We used qPCR to investigate expression of agrB, which is associated with secreted virulence factors and biofilm dispersal, cidA, which is associated with biofilm adherence and genomic DNA release, and alsS, which is associated with cell lysis, eDNA release and acid tolerance. The contribution of eDNA to the stability of the biofilm matrix was assessed by digesting with DNase I (Pulmozyme) and quantifying structure by confocal microscopy and comstat image analysis. AgrB expression initially increased at 24h but then dramatically decreased at 72h in an inverse relationship to biomass, supporting its role in regulating biofilm dispersal. cidA and alsS expression steadily increased over 72h, suggesting that eDNA was an important component of early biofilm development. DNase I had no effect on biomass, but did cause the biofilms to become more heterogeneous. Carbohydrates in the matrix appeared to play an important role in structural stability. C1 [Grande, Rossella; Nistico, Laura; Longwell, Mark; Stoodley, Luanne Hall; Stoodley, Paul] Allegheny Singer Res Inst, Ctr Genom Sci, Pittsburgh, PA 15212 USA. [Grande, Rossella; Iannitelli, Antonio; Cellini, Luigina; Di Stefano, Antonio] Univ G DAnnunzio, Dept Pharm, Chieti, Italy. [Sambanthamoorthy, Karthik] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Stoodley, Luanne Hall] Southampton Gen Hosp, WTCRF, Southampton SO9 4XY, Hants, England. [Stoodley, Luanne Hall; Stoodley, Paul] Univ Southampton, Sch Engn, nCATS, Southampton, Hants, England. [Stoodley, Paul] Ohio State Univ, Ctr Microbial Interface Biol, Dept Microbial Infect & Immun, Columbus, OH 43210 USA. [Stoodley, Paul] Ohio State Univ, Dept Orthoped, Columbus, OH 43210 USA. RP Stoodley, P (reprint author), Ohio State Univ, Ctr Microbial Interface Biol, 716 Biomed Res Tower,460 W 12th Ave, Columbus, OH 43210 USA. EM pstoodley@gmail.com RI Stoodley, Paul/E-5079-2013; OI Stoodley, Paul/0000-0001-6069-273X; Cellini, Luigina/0000-0003-4068-9124; DI STEFANO, Antonio/0000-0002-3042-2234 NR 53 TC 4 Z9 4 U1 1 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2049-632X J9 PATHOG DIS JI Pathog. Dis. PD APR PY 2014 VL 70 IS 3 SI SI BP 414 EP 422 DI 10.1111/2049-632X.12158 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AE6SH UT WOS:000334124300024 PM 24535842 ER PT J AU Carroll, J AF Carroll, James TI Russia and the US in the Cold War arms race SO PHYSICS TODAY LA English DT Letter C1 Army Res Lab, Adelphi, MD 20783 USA. RP Carroll, J (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM james.j.carroll99.civ@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 EI 1945-0699 J9 PHYS TODAY JI Phys. Today PD APR PY 2014 VL 67 IS 4 BP 10 EP 10 PG 1 WC Physics, Multidisciplinary SC Physics GA AE8QT UT WOS:000334267100005 ER PT J AU Bukreyev, AA Chandran, K Dolnik, O Dye, JM Ebihara, H Leroy, EM Muhlberger, E Netesov, SV Patterson, JL Paweska, JT Saphire, EO Smither, SJ Takada, A Towner, JS Volchkov, VE Warren, TK Kuhn, JH AF Bukreyev, Alexander A. Chandran, Kartik Dolnik, Olga Dye, John M. Ebihara, Hideki Leroy, Eric M. Muehlberger, Elke Netesov, Sergey V. Patterson, Jean L. Paweska, Janusz T. Saphire, Erica Ollmann Smither, Sophie J. Takada, Ayato Towner, Jonathan S. Volchkov, Viktor E. Warren, Travis K. Kuhn, Jens H. TI Discussions and decisions of the 2012-2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012-June 2013 SO ARCHIVES OF VIROLOGY LA English DT Article ID FAMILY FILOVIRIDAE; STANDARDIZED NOMENCLATURE; SPECIES LEVEL; CLASSIFICATION; FILOVIRUSES; VARIANTS; PROPOSAL; NAMES AB The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group prepares proposals on the classification and nomenclature of filoviruses to reflect current knowledge or to correct disagreements with the International Code of Virus Classification and Nomenclature (ICVCN). In recent years, filovirus taxonomy has been corrected and updated, but parts of it remain controversial, and several topics remain to be debated. This article summarizes the decisions and discussion of the currently acting ICTV Filoviridae Study Group since its inauguration in January 2012. C1 [Bukreyev, Alexander A.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Bukreyev, Alexander A.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Dolnik, Olga] Univ Marburg, Inst Virol, D-35032 Marburg, Germany. [Dye, John M.; Warren, Travis K.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Ebihara, Hideki] NIAID, Rocky Mt Labs, Integrated Res Facil, NIH, Hamilton, MT 59840 USA. [Leroy, Eric M.] IRD, Ctr Int Rech Med Franceville, Franceville, Gabon. [Muehlberger, Elke] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Muehlberger, Elke] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA. [Netesov, Sergey V.] Novosibirsk State Univ, Novosibirsk 630090, Novosibirsk Obl, Russia. [Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA. [Paweska, Janusz T.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Johannesburg, Gauteng, South Africa. [Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Smither, Sophie J.] DSTL, Dept Biomed Sci, Salisbury, Wilts, England. [Takada, Ayato] Hokkaido Univ, Div Global Epidemiol, Res Ctr Zoonosis Control, Sapporo, Hokkaido, Japan. [Towner, Jonathan S.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Volchkov, Viktor E.] Univ Lyon, UCB Lyon 1, Ecole Normale Super Lyon, INSERM,U758,Lab Filovirus, Lyon, France. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, Frederick, MD 21702 USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov RI Volchkov, Viktor/M-7846-2014; Kuhn, Jens H./B-7615-2011; Netesov, Sergey/A-3751-2013; LEROY, Eric/I-4347-2016 OI Volchkov, Viktor/0000-0001-7896-8706; Kuhn, Jens H./0000-0002-7800-6045; Netesov, Sergey/0000-0002-7786-2464; LEROY, Eric/0000-0003-0022-0890 FU NIAID [HHSN272200700016I] FX The content of this publication does not necessarily reflect the views or policies of the US Department of the Army, the US Department of Defense or the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. JHK performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200700016I. NR 17 TC 25 Z9 28 U1 0 U2 11 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD APR PY 2014 VL 159 IS 4 BP 821 EP 830 DI 10.1007/s00705-013-1846-9 PG 10 WC Virology SC Virology GA AE5UQ UT WOS:000334055200025 PM 24122154 ER PT J AU Silverman, AK Neptune, RR Sinitski, EH Wilken, JM AF Silverman, Anne K. Neptune, Richard R. Sinitski, Emily H. Wilken, Jason M. TI Whole-body angular momentum during stair ascent and descent SO GAIT & POSTURE LA English DT Article DE Biomechanics; Gait; Stairs; Climb; Dynamic balance ID BIOMECHANICAL ANALYSIS; SUPPORT LIMB; WALKING; BALANCE; PROGRESSION; RECOVERY; KINETICS; MASS; KNEE; HIP AB The generation of whole-body angular momentum is essential in many locomotor tasks and must be regulated in order to maintain dynamic balance. However, angular momentum has not been investigated during stair walking, which is an activity that presents a biomechanical challenge for balance-impaired populations. We investigated three-dimensional whole-body angular momentum during stair ascent and descent and compared it to level walking. Three-dimensional body-segment kinematic and ground reaction force (GRF) data were collected from 30 healthy subjects. Angular momentum was calculated using a 13-segment whole-body model. GRFs, externalmoment arms and net joint moments were used to interpret the angular momentum results. The range of frontal plane angular momentum was greater for stair ascent relative to level walking. In the transverse and sagittal planes, the range of angular momentum was smaller in stair ascent and descent relative to level walking. Significant differences were also found in the ground reaction forces, external moment arms and net joint moments. The sagittal plane angular momentum results suggest that individuals alter angular momentum to effectively counteract potential trips during stair ascent, and reduce the range of angular momentum to avoid falling forward during stair descent. Further, significant differences in joint moments suggest potential neuromuscular mechanisms that account for the differences in angular momentum between walking conditions. These results provide a baseline for comparison to impaired populations that have difficulty maintaining dynamic balance, particularly during stair ascent and descent. (C) 2014 Elsevier B.V. All rights reserved. C1 [Silverman, Anne K.] Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA. [Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. [Sinitski, Emily H.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Silverman, AK (reprint author), Colorado Sch Mines, Dept Mech Engn, 1500 Illinois St, Golden, CO 80401 USA. EM asilverm@mines.edu RI Silverman, Anne/M-2727-2016; OI Silverman, Anne/0000-0002-2228-4548; Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX This work was supported in part by a grant from the Military Amputee Research Program (to JMW). NR 27 TC 6 Z9 6 U1 1 U2 20 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 EI 1879-2219 J9 GAIT POSTURE JI Gait Posture PD APR PY 2014 VL 39 IS 4 BP 1109 EP 1114 DI 10.1016/j.gaitpost.2014.01.025 PG 6 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA AE2KI UT WOS:000333801400019 PM 24636222 ER PT J AU Moran, JM Rain, M Page-Gould, E Mar, RA AF Moran, Joseph M. Rain, Marina Page-Gould, Elizabeth Mar, Raymond A. TI Do I amuse you? Asymmetric predictors for humor appreciation and humor production SO JOURNAL OF RESEARCH IN PERSONALITY LA English DT Article DE Humor appreciation; Humor production; Motivation; Personality ID SENSE; PERSONALITY; DIMENSIONS; INTELLIGENCE; COMPETENCE; VALIDATION; ABILITY; TRAITS; STYLES; MODEL AB A "sense of humor" can be fractionated into appreciation (enjoying jokes), production fluency (making jokes), and production success (making funny jokes). There is scant research on how appreciation and production relate, and their relation to individual differences. Participants (N = 159) rated the humor of captioned cartoons and created captions for different cartoons. People who wrote funnier captions were less amused by the professionally-captioned cartoons. Production fluency, in contrast, was not related to appreciation. Personality predicted humor appreciation, but not production success. Demographics predicted production success, but not appreciation. Appreciation and production success appear to rely on separable mechanisms and motivations. Our results were also inconsistent with the idea that humor creators are motivated by dominance and humor appreciators by affiliation. (C) 2013 Elsevier Inc. All rights reserved. C1 [Moran, Joseph M.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. [Moran, Joseph M.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA. [Rain, Marina; Mar, Raymond A.] York Univ, Toronto, ON M3J 2R7, Canada. [Page-Gould, Elizabeth] Univ Toronto, Toronto, ON, Canada. RP Moran, JM (reprint author), Harvard Univ, Ctr Brain Sci, 52 Oxford St,290, Cambridge, MA 02138 USA. EM jmoran@wjh.harvard.edu NR 35 TC 2 Z9 2 U1 1 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0092-6566 EI 1095-7251 J9 J RES PERS JI J. Res. Pers. PD APR PY 2014 VL 49 BP 8 EP 13 DI 10.1016/j.jrp.2013.12.002 PG 6 WC Psychology, Social SC Psychology GA AE5EW UT WOS:000334011600002 ER PT J AU Shang, SL Wang, WY Zhou, BC Wang, Y Darling, KA Kecskes, LJ Mathaudhu, SN Liu, ZK AF Shang, S. L. Wang, W. Y. Zhou, B. C. Wang, Y. Darling, K. A. Kecskes, L. J. Mathaudhu, S. N. Liu, Z. K. TI Generalized stacking fault energy, ideal strength and twinnability of dilute Mg-based alloys: A first-principles study of shear deformation SO ACTA MATERIALIA LA English DT Article DE Stacking and twin fault energies; Twin propensity; Ideal shear strength; First-principles calculations; Pure alias shear deformation ID DENSITY-FUNCTIONAL THEORY; CROSS-SLIP STRESS; MAGNESIUM ALLOYS; HIGH-TEMPERATURE; SOLID-SOLUTION; GRADIENT APPROXIMATION; INCIPIENT PLASTICITY; AB-INITIO; METALS; ALUMINUM AB In an effort to establish a scientific foundation for the computational development of advanced Mg-based alloys, a systematic study of the generalized stacking fault (GSF) energy curves has been undertaken. Additionally, the associated stable and unstable stacking and twinning fault energies, ideal shear strengths, and comparative twinnability have been investigated in terms of first-principles calculations for dilute Mg-based alloys of type Mg95X. These GSF properties are predicted using the simple and especially the pure alias shear deformations on the basal (0 0 0 1) plane and along the [1 0 1 0] direction of the hexagonal close-packed (hcp) lattice. Fourteen alloying elements (X) are considered herein, namely Al, Ca, Cu, La, Li, Mn, Sc, Si, Sn, Sr, Ti, Y, Zn and Zr. The following conclusions are obtained: (i) the fault energies and the ideal shear strengths of Mg95X alloys decrease approximately linearly with an increasing equilibrium volume of X (or Mg95X), with the exceptions being for alloying elements Al, Cu, Si and Zn; (ii) alloying elements Sr and La greatly increase the twin propensity of hcp Mg, while Mn, Ti and Zr exhibit opposite trends; and (iii) the observed variation in GSF properties for hcp Mg caused by alloying elements X can be directly traced to the distribution of the differential charge density (triangle p) a spherical distribution of triangle p facilitates the redistribution of charge and shear deformation, resulting in lower shear-related properties, such as stacking fault energy and ideal shear strength. Computed GSF properties of Mg95X are shown to agree with available experimental and other theoretical results in the literature. (c) 2013 Acta Materialia Inc Published by Elsevier Ltd. All rights reserved. C1 [Shang, S. L.; Wang, W. Y.; Zhou, B. C.; Wang, Y.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Darling, K. A.; Kecskes, L. J.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, S. N.] US Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Shang, SL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM sus26@psu.edu RI Shang, Shun-Li/A-6564-2009; Wang, William Yi/F-8212-2011; Kecskes, Laszlo/F-6880-2014; Wang, Yi/D-1032-2013; Mathaudhu, Suveen/B-4192-2009; Zhou, Bi-Cheng/N-7411-2015; Liu, Zi-Kui/A-8196-2009 OI Shang, Shun-Li/0000-0002-6524-8897; Wang, William Yi/0000-0002-8814-525X; Kecskes, Laszlo/0000-0002-1342-3729; Zhou, Bi-Cheng/0000-0003-1560-4950; Liu, Zi-Kui/0000-0003-3346-3696 FU Army Research Lab [W911NF-08-2-0064]; National Science Foundation (NSF) [DMR-1006557]; Center for Computational Materials Design (CCMD); NSF Industry/University Cooperative Research Center at Penn State [IIP-1034965]; Georgia Tech [IIP-1034968]; Research Computing and Cyber infrastructure unit at the Pennsylvania State University; Office of Science of the US Department of Energy [DE-AC02-05CH11231]; Materials Simulation Center FX This work was financially supported by the Army Research Lab under project no. W911NF-08-2-0064, the National Science Foundation (NSF) with grant no. DMR-1006557, and the Center for Computational Materials Design (CCMD), a joint NSF Industry/University Cooperative Research Center at Penn State (IIP-1034965) and Georgia Tech (IIP-1034968). First-principles calculations were carried out partially on the LION clusters supported by the Materials Simulation Center and the Research Computing and Cyber infrastructure unit at the Pennsylvania State University, and partially on the resources of NERSC supported by the Office of Science of the US Department of Energy under contract no. DE-AC02-05CH11231. The authors also would like to thank the reviewer for constructive comments and suggestions. NR 86 TC 39 Z9 39 U1 25 U2 118 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD APR PY 2014 VL 67 BP 168 EP 180 DI 10.1016/j.actamat.2013.12.019 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AD8CX UT WOS:000333495200014 ER PT J AU Johnson, AN Hromadka, TV Carroll, M Hughes, M Jones, L Pappas, N Thomasy, C Horton, S Whitley, R Johnson, M AF Johnson, Anthony N. Hromadka, T. V., II Carroll, M. Hughes, M. Jones, L. Pappas, N. Thomasy, C. Horton, S. Whitley, R. Johnson, M. TI A computational approach to determining CVBEM approximate boundaries SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE Cauchy integral; Complex variables; Collocation; Dirichlet; Approximate boundary; Complex variable boundary element method (CVBEM) ID FUNDAMENTAL-SOLUTIONS AB The complex variable boundary element method (CVBEM) provides solutions of partial differential equations of the Laplace and Poisson type. Because the CVBEM is based upon convex combinations from a basis set of functions that are analytic throughout the problem domain, boundary, and exterior of the problem domain union boundary (except along branch cuts), both the real and imaginary parts of the CVBEM approximations satisfy the Laplace equation, leaving the modeling error reduction effort to be that of fitting the problem boundary conditions. In this paper, the approximate boundary approach is used to depict the goodness of fit between the CVBEM results and the problem boundary conditions. The approximate boundary is the locus of points where the CVBEM approximation function meets the values of the problem boundary conditions. Because of the collocation method, the approximate boundary necessarily intersects the problem boundary at least at the collocation points specified on the problem boundary. Consequently, adding nodes and collocation points on the problem boundary results in reducing the departure between the approximate boundary and the true problem boundary. Thus, the approximate boundary is developed by tracking level curves from the real and/or imaginary parts of the CVBEM approximation function. Published by Elsevier Ltd. C1 [Johnson, Anthony N.; Hromadka, T. V., II; Carroll, M.; Hughes, M.; Jones, L.; Pappas, N.; Thomasy, C.; Horton, S.] US Mil Acad, West Point, NY 10996 USA. [Whitley, R.] Univ Calif Irvine, Irvine, CA 92697 USA. [Johnson, M.] SUNY Albany, Albany, NY 12222 USA. RP Johnson, AN (reprint author), US Mil Acad, 601 Swift Rd, West Point, NY 10996 USA. EM anthony.johnson@usma.edu OI Johnson, Anthony/0000-0002-5631-6691 NR 12 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 EI 1873-197X J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD APR PY 2014 VL 41 BP 83 EP 89 DI 10.1016/j.enganabound.2013.12.011 PG 7 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA AE2FG UT WOS:000333788100009 ER PT J AU Taylor, AL Wilken, JM Deyle, GD Gill, NW AF Taylor, Alden L. Wilken, Jason M. Deyle, Gail D. Gill, Norman W. TI Knee Extension and Stiffness in Osteoarthritic and Normal Knees: A Videofluoroscopic Analysis of the Effect of a Single Session of Manual Therapy SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE manipulation; mobilization; osteoarthritis; stiffness ID JOINT STIFFNESS; RHEUMATIC CONDITIONS; COX-2 INHIBITORS; PHYSICAL-THERAPY; EXERCISE THERAPY; LEG STIFFNESS; UNITED-STATES; IN-VIVO; PREVALENCE; HIP AB STUDY DESIGN: Descriptive biomechanical study using an experimental repeated-measures design. OBJECTIVE: To quantify the response of participants with and without knee osteoarthritis (OA) to a single session of manual physical therapy. The intervention consisted primarily of joint mobilization techniques, supplemented by exercises, aiming to improve knee extension. (D BACKGROUND: While manual therapy benefits patients with knee OA, there is limited research quantifying the effects of a manual therapy treatment session on either motion or stiffness of osteoarthritic and normal knees. METHODS: The study included 5 participants with knee OA and 5 age-, gender-, and body mass index-matched healthy volunteers. Knee extension motion and stiffness were measured with videofluoroscopy before and after a 30-minute manual therapy treatment session. Analysis of variance and intraclass correlation coefficients were used to analyze the data. RESULTS: Participants with knee OA had restricted knee extension range of motion at baseline, in contrast to the participants with normal knees, who had full knee extension. After the therapy session, there was a significant increase in knee motion in participants with knee OA (P =.004) but not in those with normal knees (P =.201). For stiffness data, there was no main effect for time (P =.903) or load (P =.274), but there was a main effect of group (P =.012), with the participants with healthy knees having greater stiffness than those with knee OA. Reliability, using intraclass correlation coefficient model 3,3, for knee angle measurements between imaging sessions for all loading conditions was 0.99. Reliability (intraclass correlation coefficient model 3,1) for intraimage measurements was 0.97. CONCLUSION: End-range knee extension stiffness was greater in the participants with normal knees than those with knee OA. The combination of lesser stiffness and lack of motion in those with knee OA, which may indicate the potential for improvement, may explain why increased knee extension angle was observed following a single session of manual therapy in the participants with knee OA but not in those with normal knees. Videofluoroscopy of the knee appears reliable and relevant for future studies attempting to quantify the underlying mechanisms of manual therapy. C1 [Taylor, Alden L.; Deyle, Gail D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Mil Performance Lab, Ft Sam Houston, TX 78234 USA. [Gill, Norman W.] Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Taylor, AL (reprint author), 1360 Tractor Pass, San Antonio, TX 78154 USA. EM Alden.Taylor1914@gmail.com OI Wilken, Jason/0000-0002-5556-7667 NR 47 TC 4 Z9 4 U1 1 U2 9 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2014 VL 44 IS 4 BP 273 EP 282 DI 10.2519/jospt.2014.4710 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AE2BV UT WOS:000333779200008 PM 24568259 ER PT J AU Theiss, JL Gerber, JP Cameron, KL Beutler, AI Marshall, SW Distefano, LJ Padua, DA de la Motte, SJ Miller, JM Yunker, CA AF Theiss, Justin L. Gerber, J. Parry Cameron, Kenneth L. Beutler, Anthony I. Marshall, Stephen W. Distefano, Lindsay J. Padua, Darin A. de la Motte, Sarah J. Miller, Joseph M. Yunker, Craig A. TI Jump-Landing Differences Between Varsity, Club, and Intramural Athletes: The Jump-ACL Study SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE LESS; Landing Error Scoring System; knee; sprain; lower extremity injury ID ANTERIOR CRUCIATE LIGAMENT; ERROR SCORING SYSTEM; CLINICAL-ASSESSMENT TOOL; ASSOCIATION DIVISION-I; INJURY PREVENTION; REAL-TIME; FEMALE; PLAYERS; BIOMECHANICS; PERFORMANCE AB Theiss, JL, Gerber, JP, Cameron, KL, Beutler, AI, Marshall, SW, Distefano, LJ, Padua, DA, de la Motte, SJ, Miller, JM, and Yunker, CA. Jump-landing differences between varsity, club, and intramural athletes: The jump-ACL study. J Strength Cond Res 28(4): 1164-1171, 2014-Abnormal movement patterns have been identified as important prospective risk factors for lower extremity injury, including anterior cruciate ligament injury. Specifically, poor neuromuscular control during the early landing phase has been associated with increased injury risk. Although it is commonly assumed that higher division collegiate athletes generally exhibit better movement patterns than lower division athletes, few studies compare the biomechanical differences on basic tasks such as jump landing between various levels of athletic groups. The objective of this study was to evaluate jump-landing and fitness differences among college-aged Intramural, Competitive Club, and National Collegiate Athletic Association (NCAA) Division I level athletes. Two hundred seventy-seven student-athletes (222 men, 55 women; age 19.3 +/- 0.8 years) categorized as NCAA Division I, Competitive Club, or Intramural level athletes were evaluated during a jump-landing task using the Landing Error Scoring System (LESS), a validated qualitative movement assessment. Fitness was measured using the Army Physical Fitness Test (APFT). Results showed no significant differences in landing errors between the levels of athletic group (F-2,F-267 = 0.36, p = 0.70). There was a significant difference in landing errors between genders (F-1,F-268 = 3.99, p = 0.05). Significant differences in APFT scores were observed between level of athletic group (F-2,F-267 = 11.14, p < 0.001) and gender (F-1,F-268 = 9.27, p = 0.003). There was no significant correlation between the APFT and LESS scores (p = 0.26). In conclusion, higher level athletes had better physical fitness as measured by the APFT but did not as a group exhibit better landing technique. The implications of this research suggest that "high-risk" movement patterns are prevalent in all levels of athletes. C1 [Theiss, Justin L.; Gerber, J. Parry; Cameron, Kenneth L.; Miller, Joseph M.] Keller Army Hosp, West Point, NY 10996 USA. [Beutler, Anthony I.; de la Motte, Sarah J.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Injury Prevent Res Lab, Bethesda, MD 20814 USA. [Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol, Injury Prevent Res Ctr, Chapel Hill, NC USA. [Distefano, Lindsay J.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. [Padua, Darin A.] Univ N Carolina, Dept Exercise & Sport Sci, Sports Med Res Lab, Chapel Hill, NC USA. [Yunker, Craig A.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Theiss, JL (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM ufptboy@aol.com OI Marshall, Stephen/0000-0002-2664-9233; Cameron, Kenneth/0000-0002-6276-4482 FU United States Military Academy Department of Physical Education; Uniformed Services University of the Health Sciences; University of Connecticut; American Medical Society for Sports Medicine FX The authors acknowledge the United States Military Academy Department of Physical Education for their support of this project and the graduating class of 2014 for their participation in this study and their commitment to serve our nation. Funding support for this project was provided through grants from the Uniformed Services University of the Health Sciences, the University of Connecticut, and the American Medical Society for Sports Medicine. The views and opinions expressed in this article are those of the authors and do not reflect the views or official policy of the US Government, the Department of Defense, or the Department of the Army. NR 27 TC 8 Z9 8 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD APR PY 2014 VL 28 IS 4 BP 1164 EP 1171 DI 10.1519/JSC.0b013e3182a1fdcd PG 8 WC Sport Sciences SC Sport Sciences GA AD9AO UT WOS:000333557100039 PM 23820560 ER PT J AU Robb, ML Kim, JH AF Robb, Merlin L. Kim, Jerome H. TI Shot in the HAART: vaccine therapy for HIV SO LANCET INFECTIOUS DISEASES LA English DT Editorial Material ID LATENT INFECTION; IMMUNIZATION; GP160 C1 [Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD 20910 USA. RP Robb, ML (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mrobb@hivresearch.org NR 13 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD APR PY 2014 VL 14 IS 4 BP 259 EP 260 DI 10.1016/S1473-3099(13)70331-1 PG 2 WC Infectious Diseases SC Infectious Diseases GA AD8FJ UT WOS:000333501600003 PM 24525315 ER PT J AU Bushman, J Mishra, B Ezra, M Gul, S Schulze, C Chaudhury, S Ripoll, D Wallqvist, A Kohn, J Schachner, M Loers, G AF Bushman, J. Mishra, B. Ezra, M. Gul, S. Schulze, C. Chaudhury, S. Ripoll, D. Wallqvist, A. Kohn, J. Schachner, M. Loers, G. TI Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair SO NEUROPHARMACOLOGY LA English DT Article DE Polysialic acid; Tegaserod; Mimetic; Peripheral nerve; Regeneration; Glycan; Drug repurposing ID CELL-ADHESION MOLECULE; 5-HT4 RECEPTOR AGONIST; LONG-TERM POTENTIATION; SPINAL-CORD-INJURY; SCHWANN-CELLS; FUNCTIONAL RECOVERY; PSA-NCAM; SYNAPTIC PLASTICITY; NMDA RECEPTORS; SENSORY AXONS AB Glycans attached to the cell surface via proteins or lipids or exposed in the extracellular matrix affect many cellular processes, including neuritogenesis, cell survival and migration, as well as synaptic activity and plasticity. These functions make glycans attractive molecules for stimulating repair of the injured nervous system. Yet, glycans are often difficult to synthesize or isolate and have the disadvantage to be unstable in a complex tissue environment. To circumvent these issues, we have screened a library of small organic compounds to search for structural and functional mimetics of the neurostimulatory glycan polysialic acid (PSA) and identified the 5-HT4 receptor agonist tegaserod as a PSA mimetic. The PSA mimicking activity of tegaserod was shown in cultures of central and peripheral nervous system cells of the mouse and found to be independent of its described function as a serotonin (5-HT4) receptor agonist. In an in vivo model for peripheral nerve regeneration, mice receiving tegaserod at the site of injury showed enhanced recovery compared to control mice receiving vehicle control as evidenced by functional measurements and histology. These data indicate that tegaserod could be repurposed for treatment of nervous system injuries and underscores the potential of using small molecules as mimetics of neurostimulatory glycans. (C) 2013 Published by Elsevier Ltd. C1 [Bushman, J.; Ezra, M.; Kohn, J.] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA. [Mishra, B.; Schulze, C.; Schachner, M.; Loers, G.] Univ Med Ctr Hamburg Eppendorf, Ctr Mol Neurobiol, D-20246 Hamburg, Germany. [Gul, S.] European ScreeningPort GmbH, D-22525 Hamburg, Germany. [Chaudhury, S.; Ripoll, D.; Wallqvist, A.] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Schachner, M.] Rutgers State Univ, Keck Ctr Collaborat Neurosci, Piscataway, NJ 08854 USA. RP Schachner, M (reprint author), Rutgers State Univ, Dept Cell Biol & Neurosci, Nelson Labs D251, 604 Allison Rd, Piscataway, NJ 08854 USA. EM schachner@biology.rutgers.edu OI wallqvist, anders/0000-0002-9775-7469 FU NINDS NIH HHS [R01 NS078385] NR 70 TC 10 Z9 11 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0028-3908 EI 1873-7064 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD APR PY 2014 VL 79 BP 456 EP 466 DI 10.1016/j.neuropharm.2013.09.014 PG 11 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA AE1ZX UT WOS:000333774200047 PM 24067923 ER PT J AU Edwards, J Bahjat, A Jiang, YR Cook, T La Porta, TF AF Edwards, James Bahjat, Ahmed Jiang, Yurong Cook, Trevor La Porta, Thomas F. TI Quality of information-aware mobile applications SO PERVASIVE AND MOBILE COMPUTING LA English DT Article DE Quality of Information; QoI; Resource allocation; Networking framework; Tactical networks; Timeliness; Accuracy AB In this paper, we propose a framework for providing Quality of Information (QoI) aware networking. QoI quantifies how useful information is for a given application. Its value is comprised of both intrinsic and contextual attributes related to the information. Intrinsic attributes include freshness and accuracy of the information. Contextual metrics include completeness and timeliness. To design QoI-aware network control algorithms, such as resource control algorithms, attributes of data must be mapped to QoI. Then, network algorithms may deliver the data in such a way that the ultimate information derived from the data is of sufficient quality for its purpose. We propose our QoI framework, and present the concept of QoI functions that capture tradeoffs between different attributes of QoI. We use optical character recognition (OCR) as a model image processing application. We focus on two attributes of QoI for the OCR application: accuracy and timeliness. We show how network controls and data processing, such as error recovery and compression, operating on data, impact the QoI delivered to a recipient. We then show how reductions in the required QoI may have a drastic impact on the amount of network resources required to support a QoI-aware transaction. Our results are based on an implementation on Android phones. (C) 2013 Elsevier B. V. All rights reserved. C1 [Edwards, James; La Porta, Thomas F.] Penn State Univ, University Pk, PA 16802 USA. [Bahjat, Ahmed] King Fahd Univ, Dhahran, Saudi Arabia. [Jiang, Yurong] Univ So Calif, Los Angeles, CA 90089 USA. [Cook, Trevor] US Army Res Lab, Adelphi, MD USA. RP Edwards, J (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM jedwards@cse.psu.edu; yurongji@usc.edu; trevor.j.cook.civ@mail.mil; tlp@cse.psu.edu FU Army Research Laboratory [W911NF-09-2-0053] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 11 TC 5 Z9 5 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1574-1192 EI 1873-1589 J9 PERVASIVE MOB COMPUT JI Pervasive Mob. Comput. PD APR PY 2014 VL 11 BP 216 EP 228 DI 10.1016/j.pmcj.2013.05.003 PG 13 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AE2OW UT WOS:000333813800015 ER PT J AU Childs, JD Wu, SS Teyhen, DS Robinson, ME George, SZ AF Childs, John D. Wu, Samuel S. Teyhen, Deydre S. Robinson, Michael E. George, Steven Z. TI Prevention of low back pain in the military cluster randomized trial: effects of brief psychosocial education on total and low back pain-related health care costs SO SPINE JOURNAL LA English DT Article DE Costs; Low back pain; Prevention; Biopsychosocial; Military ID CORE STABILIZATION EXERCISES; OPERATION IRAQI FREEDOM; LOST PRODUCTIVE TIME; MANAGEMENT; SOLDIERS; VALIDITY; POLM; INTERVENTION; NCT00373009; RELIABILITY AB BACKGROUND CONTEXT: Effective strategies for preventing low back pain (LBP) have remained elusive, despite annual direct health care costs exceeding $85 billion dollars annually. In our recently completed Prevention of Low Back Pain in the Military (POLM) trial, a brief psychosocial education program (PSEP) that reduced fear and threat of LBP reduced the incidence of health care-seeking for LBP. PURPOSE: The purpose of this cost analysis was to determine if soldiers who received psychosocial education experienced lower health care costs compared with soldiers who did not receive psychosocial education. STUDY DESIGN/SETTING: The POLM trial was a cluster randomized trial with four intervention arms and a 2-year follow-up. Consecutive subjects (n=4,295) entering a 16-week training program at Fort Sam Houston, TX, to become a combat medic in the U.S. Army were considered for participation. METHODS: In addition to an assigned exercise program, soldiers were cluster randomized to receive or not receive a brief psychosocial education program delivered in a group setting. The Military Health System Management Analysis and Reporting Tool was used to extract total and LBP-related health care costs associated with LBP incidence over a 2-year follow-up period. RESULTS: After adjusting for postrandomization differences between the groups, the median total LBP-related health care costs for soldiers who received PSEP and incurred LBP-related costs during the 2-year follow-up period were $26 per soldier lower than for those who did not receive PSEP ($60 vs. $86, respectively, p=.034). The adjusted median total health care costs for soldiers who received PSEP and incurred at least some health care costs during the 2-year follow-up period were estimated at $2 per soldier lower than for those who did not receive PSEP ($2,439 vs. $2,441, respectively, p=.242). The results from this analysis demonstrate that a brief psychosocial education program was only marginally effective in reducing LBP-related health care costs and was not effective in reducing total health care costs. Had the 1,995 soldiers in the PSEP group not received PSEP, we would estimate that 16.7% of them would incur an adjusted median LBP-related health care cost of $517 compared with the current 15.0% soldiers incurring an adjusted median cost of $399, which translates into an actual LBP-related health care cost savings of $52,846 during the POLM trial. However, it is likely that the unaccounted for direct and indirect costs might erase even these small cost savings. CONCLUSION: The results of this study will help to inform policy- and decision-making regarding the feasibility of implementing psychosocial education in military training environments across the services. It would be interesting to explore in future research whether cost savings from psychosocial education could be enhanced given a more individualized delivery method tailored to an individual's specific psychosocial risk factors. Published by Elsevier Inc. C1 [Childs, John D.] Dept Phys Therapy MSGS SGCUY, Med Grp 81, Biloxi, MS 39534 USA. [Childs, John D.; Teyhen, Deydre S.] US Army Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Wu, Samuel S.] Univ Florida, Dept Biostat, Gainesville, FL 32610 USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21774 USA. [Robinson, Michael E.; George, Steven Z.] Univ Florida, Ctr Pain Res & Behav Hlth, Gainesville, FL 32610 USA. [Robinson, Michael E.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA. [George, Steven Z.] Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA. RP Childs, JD (reprint author), Dept Phys Therapy MSGS SGCUY, Med Grp 81, 2532 Melville Ln, Biloxi, MS 39534 USA. EM childsjd@gmail.com FU Peer Reviewed Medical Research Program of the Department of Defense [PR054098] FX The POLM cluster randomized trial was supported by the Peer Reviewed Medical Research Program of the Department of Defense (PR054098). All authors were independent from this funding program and the funding program played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. All contributing authors had access to all study data and take final responsibility for paper submission. NR 40 TC 5 Z9 5 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD APR PY 2014 VL 14 IS 4 BP 571 EP 583 DI 10.1016/j.spinee.2013.03.019 PG 13 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AD6YB UT WOS:000333406300004 PM 23608562 ER PT J AU Knox, JB Orchowski, JR Scher, DL Owens, BD Burks, R Belmont, PJ AF Knox, Jeffrey B. Orchowski, Joseph R. Scher, Danielle L. Owens, Brett D. Burks, Robert Belmont, Philip J., Jr. TI Occupational driving as a risk factor for low back pain in active-duty military service members SO SPINE JOURNAL LA English DT Article DE Low back pain; Epidemiology; Motor vehicle operator ID WHOLE-BODY VIBRATION; URBAN TRANSIT OPERATORS; TAXI DRIVERS; NECK PAIN; MUSCULOSKELETAL DISORDERS; PSYCHOSOCIAL FACTORS; PHYSICAL WORKLOAD; NATIONAL SURVEYS; UNITED-STATES; BUS DRIVERS AB BACKGROUND CONTEXT: Although occupational driving has been associated with low back pain, little has been reported on the incidence rates for this disorder. PURPOSE: To determine the incidence rate and demographic risk factors of low back pain in an ethnically diverse and physically active population of US military vehicle operators. STUDY DESIGN/SETTING: Retrospective database analysis. PATIENT SAMPLE: All active-duty military service members between 1998 and 2006. OUTCOME MEASURES: Low back pain requiring visit to a health-care provider. METHODS: A query was performed using the US Defense Medical Epidemiology Database for the International Classification of Diseases, Ninth Revision, Clinical Modification code for low back pain (724.20). Multivariate Poisson regression analysis was used to estimate the rate of low back pain among military vehicle operators and control subjects per 1,000 person-years, while controlling for sex, race, rank, service, age, and marital status. RESULTS: A total of 8,447,167 person-years of data were investigated. The overall unadjusted low back pain incidence rate for military members whose occupation is vehicle operator was 54.2 per 1,000 person-years. Compared with service members with other occupations, motor vehicle operators had a significantly increased adjusted incidence rate ratio (IRR) for low back pain of 1.15 (95% confidence interval [CI] 1.13-1.17). Female motor vehicle operators, compared with males, had a significantly increased adjusted IRR for low back pain of 1.45 (95% CI 1.39-1.52). With senior enlisted as the referent category, the junior enlisted rank group of motor vehicle operators had a significantly increased adjusted IRR for low back pain: 1.60 (95% CI 1.52-1.70). Compared with Marine service members, those motor vehicle operators in both the Army, 2.74 (95% CI 2.60-2.89), and the Air Force, 1.98 (95% CI 1.84-2.14), had a significantly increased adjusted IRR for low back pain. The adjusted IRRs for the less than 20-year and more than 40-year age groups, compared with the 30- to 39-year age group, were 1.24 (1.15-1.36) and 1.23 (1.10-1.38), respectively. CONCLUSIONS: Motor vehicle operators have a small but statistically significantly increased rate of low back pain compared with matched control population. Published by Elsevier Inc. C1 [Knox, Jeffrey B.; Orchowski, Joseph R.] Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Scher, Danielle L.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Surg Serv, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Hosp, Dept Orthopaed Surg, West Point, NY 10996 USA. [Burks, Robert] Naval Postgrad Sch, Grad Sch Operat & Informat Sci, Monterey, CA 93940 USA. RP Knox, JB (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.bruce.knox@us.army.mil OI Belmont, Philip/0000-0003-2618-199X NR 49 TC 3 Z9 3 U1 6 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD APR PY 2014 VL 14 IS 4 BP 592 EP 597 DI 10.1016/j.spinee.2013.06.029 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AD6YB UT WOS:000333406300006 PM 23992937 ER PT J AU Tsiligkaridis, T Sadler, BM Hero, AO AF Tsiligkaridis, Theodoros Sadler, Brian M. Hero, Alfred O., III TI Collaborative 20 Questions for Target Localization SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE Optimal query selection; machine-machine interaction; target localization; convergence rate; minimum entropy; human-aided decision making AB We consider the problem of 20 questions with noise for multiple players under the minimum entropy criterion in the setting of stochastic search, with application to target localization. Each player yields a noisy response to a binary query governed by a certain error probability. First, we propose a sequential policy for constructing questions that queries each player in sequence and refines the posterior of the target location. Second, we consider a joint policy that asks all players questions in parallel at each time instant and characterize the structure of the optimal policy for constructing the sequence of questions. This generalizes the single player probabilistic bisection method for stochastic search problems. Third, we prove an equivalence between the two schemes showing that, despite the fact that the sequential scheme has access to a more refined filtration, the joint scheme performs just as well on average. Fourth, we establish convergence rates of the mean-square error and derive error exponents. Finally, we obtain an extension to the case of unknown error probabilities. This framework provides a mathematical model for incorporating a human in the loop for active machine learning systems. C1 [Tsiligkaridis, Theodoros; Hero, Alfred O., III] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Tsiligkaridis, T (reprint author), MIT Lincoln Lab, Lexington, MA 02421 USA. EM ttsili@ll.mit.edu; brian.m.sadler6.civ@mail.mil; hero@umich.edu FU ARO [W911NF-11-1-0391] FX This work was supported by ARO under Grant W911NF-11-1-0391. This paper was presented at the 2013 IEEE International Conference on Acoustics, Speech and Signal Processing and the 2013 IEEE GlobalSIP-Symposium on Controlled Sensing for Inference: Applications, Theory and Algorithms. NR 28 TC 11 Z9 11 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 EI 1557-9654 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD APR PY 2014 VL 60 IS 4 BP 2233 EP 2252 DI 10.1109/TIT.2014.2304455 PG 20 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA AD2XG UT WOS:000333099400017 ER PT J AU Kumar, R Angov, E Kumar, N AF Kumar, Rajesh Angov, Evelina Kumar, Nirbhay TI Potent Malaria Transmission-Blocking Antibody Responses Elicited by Plasmodium falciparum Pfs25 Expressed in Escherichia coli after Successful Protein Refolding SO INFECTION AND IMMUNITY LA English DT Article ID IN-VIVO ELECTROPORATION; CELL-FREE SYSTEM; VACCINE CANDIDATE; DISULFIDE-ISOMERASE; FUSION PROTEINS; SEXUAL STAGE; MICE; DNA; IMMUNITY; SOLUBILIZATION AB Production of Pfs25, a Plasmodium falciparum transmission-blocking vaccine target antigen, in functional conformation with the potential to elicit effective immunogenicity still remains a major challenge. In the current study, codon-harmonized recombinant Pfs25 (CHrPfs25) was expressed in Escherichia coli, and purified protein after simple oxidative refolding steps retained reduction-sensitive conformational epitopes of transmission-blocking monoclonal antibodies. CHrPfs25 formulated in several adjuvants elicited strong immunogenicity in preclinical studies in mice. Antibodies elicited after immunization recognized native Pfs25 on the surface of live gametes of P. falciparum and demonstrated complete malaria transmission-blocking activity. The transmission-blocking efficacy was 100% even after a 1:128 dilution of sera from immunized mice in the complete Freund's adjuvant and Montanide ISA51 groups and after a 1:16 dilution of sera from mice in the alum group. The blocking was mediated by antibodies; purified IgG at concentrations as low as 31.25 mu g/ml exhibited 100% transmission blocking in membrane feeding assays employing two different species of mosquitoes, Anopheles gambiae and Anopheles stephensi. This study provides the first evidence for successful expression of biologically functional rPfs25 in E. coli. The extremely potent malaria transmission-blocking activity of antibodies elicited by immunization with purified protein provides strong support for further evaluation of E. coli-derived CHrPfs25 as a malaria transmission-blocking vaccine in human clinical trials. C1 [Kumar, Rajesh; Kumar, Nirbhay] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70118 USA. [Kumar, Rajesh; Kumar, Nirbhay] Tulane Univ, Sch Publ Hlth & Trop Med, Vector Borne Infect Dis Res Ctr, New Orleans, LA USA. [Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Kumar, N (reprint author), Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70118 USA. EM nkumar@tulane.edu FU NIH [RO1AI47089, R21AI101427] FX This research was supported by NIH grants RO1AI47089 and R21AI101427. NR 40 TC 15 Z9 15 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2014 VL 82 IS 4 BP 1453 EP 1459 DI 10.1128/IAI.01438-13 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AD4BX UT WOS:000333192300012 PM 24421036 ER PT J AU Quadrato, C Battistini, A Helwig, T Engelhardt, M Frank, K AF Quadrato, Craig Battistini, Anthony Helwig, Todd Engelhardt, Michael Frank, Karl TI Increasing Girder Elastic Buckling Strength Using Split Pipe Bearing Stiffeners SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Plate girders; Stability; Steel bridges; Girder bridges; Buckling ID BEAMS AB Warping restraining devices can result in substantial improvements in the girder elastic buckling capacity; however, calculating this increase can be complex. This paper presents a simplified method to evaluate the increase in elastic buckling strength and corresponding unbraced length due to improved warping restraint provided by split pipe stiffeners located at the ends of doubly symmetric W-shapes. The solution is based on analytical studies and results from a finite-element parametric study validated using large-scale laboratory tests. The laboratory tests include specimens exposed to concentrated loads with split pipe warp-restraining devices and others with standard plate stiffeners. The proposed analytic method is based on uniform moment and shows that warping restraint can increase the elastic buckling capacity of a girder by 30-100%. The improved warping stiffness can result in increases in the unbraced length in the range of 20-35% compared with systems with plate stiffeners. C1 [Quadrato, Craig] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Battistini, Anthony; Helwig, Todd; Frank, Karl] Univ Texas Austin, Austin, TX 78758 USA. [Engelhardt, Michael] Univ Texas Austin, Dewitt C Greer Centennial Prof Transportat Engn, Austin, TX 78758 USA. RP Quadrato, C (reprint author), US Mil Acad, Dept Civil & Mech Engn, Bldg 752,Mahan Hall,Room 329, West Point, NY 10996 USA. EM craig.quadrato@usma.edu; adb892@mail.utexas.edu; thelwig@mail.utexas.edu; mde@mail.utexas.edu; kfrank@uts.cc.utexas.edu FU Texas DOT; Ferguson Structural Engineering Laboratory FX This research study was conducted with the support of the Texas DOT and the Ferguson Structural Engineering Laboratory. The authors thank both of these organizations for their generous support. NR 19 TC 0 Z9 0 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD APR 1 PY 2014 VL 19 IS 4 DI 10.1061/(ASCE)BE.1943-5592.0000550 PG 7 WC Engineering, Civil SC Engineering GA AC7XZ UT WOS:000332748900002 ER PT J AU Russell, BR Thrall, AP Padula, JA Fowler, JE AF Russell, Brittani R. Thrall, Ashley P. Padula, Joseph A. Fowler, Jimmy E. TI Reconceptualization and Optimization of a Rapidly Deployable Floating Causeway SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Military engineering; Bridges; Optimization; Floating structures; Composite material ID BRIDGE DECK; MULTIOBJECTIVE OPTIMIZATION; HEURISTIC OPTIMIZATION; DESIGN; ALGORITHMS AB There is an increasing demand for rapidly deployable causeways that can provide access from ship-to-shore for military and disaster relief operations. Existing systems have major limitations including only being transportable and emplaceable by large strategic sealift vessels, having high weight and packaged volumes, and requiring intensive on-site assembly. In response to the demand for a lightweight, air-liftable, quickly emplaceable causeway, the Engineer Research and Development Center (Vicksburg, Mississippi) developed a prototype comprised of aluminum modules joined by compliant connections and supported by pneumatic floats. As research and development progressed and experience was gained, eliminating the heavy and complex compliant connections was identified as a potential improvement. To eliminate these compliant connections, this paper shows how this design can be reconceptualized so a desired superstructure flexibility (that takes advantage of buoyancy while meeting deflection limits) is achieved. The superstructure has been designed for a target stiffness to permit a desired curvature under a design moment. This paper will review existing causeways, present this reconceptualization, and discuss the optimization implemented to achieve this new design. C1 [Russell, Brittani R.; Thrall, Ashley P.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Padula, Joseph A.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Fowler, Jimmy E.] US Army Engineer Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Thrall, AP (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. EM brussel2@nd.edu; athrall@nd.edu; joseph.a.padula@usace.army.mil; jimmy.e.fowler@usace.army.mil RI Thrall, Ashley/D-4664-2016 OI Thrall, Ashley/0000-0002-4026-3847 FU University of Notre Dame's Center for Research Computing FX The writers acknowledge all those involved in the design of the Lightweight Modular Causeway System. This research was supported in part by the University of Notre Dame's Center for Research Computing through computational resources. NR 38 TC 2 Z9 2 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD APR 1 PY 2014 VL 19 IS 4 DI 10.1061/(ASCE)BE.1943-5592.0000539 PG 9 WC Engineering, Civil SC Engineering GA AC7XZ UT WOS:000332748900011 ER PT J AU Hutchison, TN Krueger, CA Berry, JS Aden, JK Cohn, SM White, CE AF Hutchison, Tara N. Krueger, Chad A. Berry, John S. Aden, James K. Cohn, Stephen M. White, Christopher E. TI Venous thromboembolism during combat operations: a 10-y review SO JOURNAL OF SURGICAL RESEARCH LA English DT Review DE Trauma; Combat; Venous thromboembolism; Deep venous thrombosis; Pulmonary embolism; Amputation; War ID DEEP-VEIN THROMBOSIS; SPINAL-CORD-INJURY; PULMONARY-EMBOLISM; TRAUMA PATIENTS; MAJOR TRAUMA; LOWER-EXTREMITY; FRACTURES AB Background: This article examines the incidence of venous thromboembolism (VTE) in combat wounded, identifies risk factors for pulmonary embolism (PE), and compares the rate of PE in combat with previously reported civilian data. Methods: A retrospective review was performed of all U. S. military combat casualties in Operation Enduring Freedom and Operation Iraqi Freedom with a VTE recorded in the Department of Defense Trauma Registry from September 2001 to July 2011. The Military Amputation Database of all U. S. military amputations during the same 10-y period was also reviewed. Demographic data, injury characteristics, and outcomes were evaluated. Results: Among 26,634 subjects, 587 (2.2%) had a VTE. This number included 270 subjects (1.0%) with deep venous thrombosis (DVT), 223 (0.8%) with PE, and 94 (0.4%) with both DVT and PE. Lower extremity amputation was independently associated with PE (odds ratio [OR], 1.70; 95% confidence interval [CI], 1.07-2.69). A total of 1003 subjects suffered a lower extremity amputation, with 174 (17%) having a VTE. Of these, 75 subjects (7.5%) were having DVT, 70 (7.0%) were having PE, and 29 (2.9%) were found to have both a DVT and a PE. Risk factors found to be independently associated with VTE in amputees were multiple amputations (OR, 2; 95% CI, 1.35-3.42) and above the knee amputation (OR, 2.11; 95% CI, 1.3-3.32). Conclusions: Combat wounded are at a high risk for thromboembolic complications with the highest risk associated with multiple or above the knee amputations. Published by Elsevier Inc. C1 [Hutchison, Tara N.; Krueger, Chad A.; Berry, John S.; Aden, James K.; Cohn, Stephen M.; White, Christopher E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM christopher.eric.white@us.army.mil FU Oak Ridge Institute for Science and Education (ORISE) FX Support for this work was provided by a grant from the Oak Ridge Institute for Science and Education (ORISE). NR 18 TC 5 Z9 5 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD APR PY 2014 VL 187 IS 2 BP 625 EP 630 DI 10.1016/j.jss.2013.11.008 PG 6 WC Surgery SC Surgery GA AC8GD UT WOS:000332770600035 PM 24405609 ER PT J AU Wideman, TH Finan, PH Edwards, RR Quartana, PJ Buenaver, LF Haythornthwaite, JA Smith, MT AF Wideman, Timothy H. Finan, Patrick H. Edwards, Robert R. Quartana, Phillip J. Buenaver, Luis F. Haythornthwaite, Jennifer A. Smith, Michael T. TI Increased sensitivity to physical activity among individuals with knee osteoarthritis: Relation to pain outcomes, psychological factors, and responses to quantitative sensory testing SO PAIN LA English DT Article DE Activity-related pain; Chronic pain; Depression; Knee osteoarthritis; Mechanical pain; Musculoskeletal pain; Pain catastrophizing; Pain threshold; Pain-related function; Physical activity; Psychological factors; Quantitative sensory testing; Sensitivity to physical activity; Temporal summation of pain ID QUALITY-OF-LIFE; CLINICAL-PRACTICE GUIDELINES; ACTIVITY-RELATED SUMMATION; SLOW TEMPORAL SUMMATION; FEAR-AVOIDANCE MODEL; FIBER-EVOKED PAIN; BACK-PAIN; CATASTROPHIZING SCALE; FIBROMYALGIA PATIENTS; CENTRAL SENSITIZATION AB Recent findings suggest that certain individuals with musculoskeletal pain conditions have increased sensitivity to physical activity ( SPA) and respond to activities of stable intensity with increasingly severe pain. This study aimed to determine the degree to which individuals with knee osteoarthritis (OA) show heightened SPA in response to a standardized walking task and whether SPA cross-sectionally predicts psychological factors, responses to quantitative sensory testing (QST), and different OA-related outcomes. One hundred seven adults with chronic knee OA completed self-report measures of pain, function, and psychological factors, underwent QST, and performed a 6-min walk test. Participants rated their discomfort levels throughout the walking task; an index of SPA was created by subtracting first ratings from peak ratings. Repeated-measure analysis of variance revealed that levels of discomfort significantly increased throughout the walking task. A series of hierarchical regression analyses determined that after controlling for significant covariates, psychological factors, and measures of mechanical pain sensitivity, individual variance in SPA predicted self-report pain and function and performance on the walking task. Analyses also revealed that both pain catastrophizing and the temporal summation of mechanical pain were significant predictors of SPA and that SPA mediated the relationship between catastrophizing and self- reported pain and physical function. The discussion addresses the potential processes contributing to SPA and the role it may play in predicting responses to different interventions for musculoskeletal pain conditions. (C) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. C1 [Wideman, Timothy H.; Finan, Patrick H.; Buenaver, Luis F.; Haythornthwaite, Jennifer A.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA. [Edwards, Robert R.] Harvard Univ, Sch Med, Dept Anaesthesia, Boston, MA 02115 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP Wideman, TH (reprint author), Johns Hopkins Univ, Ctr Mind Body Res, Bayview Campus,5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. EM twidema1@jhu.edu FU Canadian Institutes for Health Research (CIHR); Fonds de Recherche Sante Quebec (FRSQ) FX Supported in part by funds from the Canadian Institutes for Health Research (CIHR) and the Fonds de Recherche Sante Quebec (FRSQ). The authors would like to thank the anonymous reviewers of this manuscript for their helpful comments on an earlier version of this paper. NR 98 TC 9 Z9 9 U1 2 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD APR PY 2014 VL 155 IS 4 BP 703 EP 711 DI 10.1016/j.pain.2013.12.028 PG 9 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA AD2YG UT WOS:000333102400010 PM 24378879 ER PT J AU Katzarova, M Andreev, M Sliozberg, YR Mrozek, RA Lenhart, JL Andzelm, JW Schieber, JD AF Katzarova, Maria Andreev, Marat Sliozberg, Yelena R. Mrozek, Randy A. Lenhart, Joseph L. Andzelm, Jan W. Schieber, Jay D. TI Rheological predictions of network systems swollen with entangled solvent SO AICHE JOURNAL LA English DT Article DE gels, networks; rheology; multiscale modeling; mathematical modeling; polymer properties ID SLIP-LINK MODEL; CHAIN-LENGTH FLUCTUATIONS; POLYMER NETWORKS; MECHANICAL-PROPERTIES; MOLECULAR-WEIGHT; GELS; CONNECTIVITY; RELAXATION; ELASTICITY; SLIPLINKS AB The mechanical properties of a cross-linked polydimethylsiloxane (PDMS) network swollen with nonreactive entangled PDMS solvent was previously studied experimentally. In this article, we use the discrete slip-link model to predict its linear and nonlinear rheology. Model parameters are obtained from the dynamic modulus data of pure solvent. Network rheology predictions also require an estimate of the fraction and architecture of dangling or inactive strands in the network, which is not directly measurable. The active strand fraction is estimated from dynamic modulus measurements, and the molecular weight is adjusted to fit the dynamic modulus data. Then, the nonlinear rheology can be predicted without adjustments. These successful predictions strongly suggest that the observed rheological modification in the swollen blend arises from the constraint dynamics between the network chains and the dangling ends. (c) 2014 American Institute of Chemical Engineers AIChE J, 60: 1372-1380, 2014 We dedicate this article to Prof. R. Byron Bird on the occasion of his 90th birthday. We attempt to follow the twin exhortations of Bob to be both mathematically rigorous and practically relevant. C1 [Katzarova, Maria] IIT, Dept Chem & Biol Engn, Chicago, IL 60616 USA. [Katzarova, Maria; Schieber, Jay D.] IIT, Ctr Mol Study Condensed Soft Matter, Chicago, IL 60616 USA. [Andreev, Marat] IIT, Dept Phys, Chicago, IL 60616 USA. [Sliozberg, Yelena R.; Mrozek, Randy A.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Aberdeen, MD 21005 USA. [Sliozberg, Yelena R.] Bowhead Sci & Technol, King George, VA 22485 USA. [Schieber, Jay D.] IIT, Dept Chem & Biol Engn, Dept Phys, Chicago, IL 60616 USA. RP Schieber, JD (reprint author), IIT, Dept Chem & Biol Engn, Dept Phys, Chicago, IL 60616 USA. EM schieber@iit.edu RI Andreev, Marat/J-2317-2014; Katzarova, Maria/O-3513-2015; OI Schieber, Jay/0000-0002-9644-5236 FU Army Research Office [W911NF-08-2-0058, W911NF-09-2-0071] FX The authors are grateful to the Army Research Office (W911NF-08-2-0058 and W911NF-09-2-0071) for financial support. M. Katzarova thanks Andres Cordoba for insightful discussions. NR 28 TC 5 Z9 5 U1 1 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0001-1541 EI 1547-5905 J9 AICHE J JI AICHE J. PD APR PY 2014 VL 60 IS 4 BP 1372 EP 1380 DI 10.1002/aic.14370 PG 9 WC Engineering, Chemical SC Engineering GA AC5YH UT WOS:000332596400016 ER PT J AU Moseman, E Storm, C AF Moseman, Elizabeth Storm, Christopher TI On the Oriented Line Graph SO ARS COMBINATORIA LA English DT Article AB Kotani and Sunada introduced the oriented line graph as a tool in the study of the Ihara zeta function of a finite graph. The spectral properties of the adjacency operator on the oriented line graph can be linked to the Ramanujan condition of the graph. Here, we present a partial characterization of oriented line graphs in terms of forbidden subgraphs. We also give a Whitney-type result, as a special case of a result by Balof and Storm, establishing that if two graphs have the same oriented line graph, they are isomorphic. C1 [Moseman, Elizabeth] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Storm, Christopher] Adelphi Univ, Dept Math & Comp Sci, Garden City, NY 21402 USA. RP Moseman, E (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM lizz.moseman@usma.edu; cstorm@adelphi.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU CHARLES BABBAGE RES CTR PI WINNIPEG PA PO BOX 272 ST NORBERT POSTAL STATION, WINNIPEG, MB R3T 2N2, CANADA SN 0381-7032 J9 ARS COMBINATORIA JI ARS Comb. PD APR PY 2014 VL 114 BP 397 EP 416 PG 20 WC Mathematics SC Mathematics GA AD2KT UT WOS:000333065300039 ER PT J AU Edwards, CE Lindsay, DL Bailey, P Lance, RF AF Edwards, Christine E. Lindsay, Denise L. Bailey, Pamela Lance, Richard F. TI Patterns of genetic diversity in the rare Erigeron lemmoni and comparison with its more widespread congener, Erigeron arisolius (Asteraceae) SO CONSERVATION GENETICS LA English DT Article DE Erigeron; Genetic diversity; Rare and widespread congeners; Microsatellite; Conservation ID ALLELE FREQUENCY DATA; RECENT POPULATION BOTTLENECKS; MULTILOCUS GENOTYPE DATA; SELF-INCOMPATIBILITY; CONSERVATION GENETICS; CROSS-COMPATIBILITY; PLANT CONGENERS; NULL ALLELES; DIFFERENTIATION; SIZE AB Analysis of levels and patterns of genetic variation in a rare species is important for determining whether genetic factors associated with small population size, such as genetic drift or inbreeding, may be negatively affecting a species. In this study, we compared estimates of genetic diversity and patterns of population genetic structure in a rare cliff endemic, Erigeron lemmonii, to those of a widespread congener, E. arisolius. Our goals were to assess whether rarity and small population size have negatively affected levels of genetic diversity in E. lemmonii and to identify genetic threats that may limit the ability of E. lemmonii to persist. Levels of observed and expected heterozygosity and allelic richness in E. lemmonii were approximately 60 % of those found in E. arisolius. After correcting for null alleles, inbreeding coefficients in both species of Erigeron were very small, suggesting that both species are highly outcrossing and may demonstrate self-incompatibility. Patterns of genetic structure in both species revealed almost no population substructuring, indicating that widespread gene flow is occurring within each species. Because we found no evidence for inbreeding or a genetic bottleneck in E. lemmonii, it is likely that the species' lower genetic diversity may be the result of genetic drift. Because E. lemmoni exists in a single population, no other populations exist to bolster population size or genetic diversity in the event of declines; thus, conservation efforts should focus on seed collection from as many individuals as possible to protect against possible future losses of genetic diversity. We also recommend continued monitoring of both population size and genetic diversity in E. lemmonii to ensure the species' long-term persistence and viability. C1 [Edwards, Christine E.; Lindsay, Denise L.; Bailey, Pamela; Lance, Richard F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Edwards, Christine E.] Missouri Bot Garden, Ctr Conservat & Sustainable Dev, St Louis, MO 63166 USA. RP Edwards, CE (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM cedwar10@gmail.com OI Edwards, Christine/0000-0001-8837-4872 FU 6.1 Basic Research grant from U.S. Army Engineer Research and Development Center's Environmental Quality Technology Program [09-03] FX The authors thank M. G. Jung, J. L. Anderson, C. G. Cox, B. L. Escalon, and A. J. Hollingsworth for assistance with field and lab work, S. Stone for assistance with collection permits and access to Fort Huachuca; and H. L. Farrington and S. Stone for comments on a previous version of this manuscript. The study described and the resulting data presented herein were obtained from research conducted under a 6.1 Basic Research grant (Project 09-03) from the U.S. Army Engineer Research and Development Center's Environmental Quality Technology Program. NR 48 TC 3 Z9 3 U1 1 U2 25 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1566-0621 EI 1572-9737 J9 CONSERV GENET JI Conserv. Genet. PD APR PY 2014 VL 15 IS 2 BP 419 EP 428 DI 10.1007/s10592-013-0549-9 PG 10 WC Biodiversity Conservation; Genetics & Heredity SC Biodiversity & Conservation; Genetics & Heredity GA AC8BV UT WOS:000332758900015 ER PT J AU Bose, N Wurst, LR Chan, ASH Dudney, CM LeRoux, ML Danielson, ME Will, PM Nodland, SE Patchen, ML Dalle Lucca, JJ Lebeda, FJ Vasilakos, JP AF Bose, Nandita Wurst, Lindsay R. Chan, Anissa S. H. Dudney, Christine M. LeRoux, Megan L. Danielson, Michael E. Will, Paul M. Nodland, Sonja E. Patchen, Myra L. Dalle Lucca, Jurandir J. Lebeda, Frank J. Vasilakos, John P. TI Differential regulation of oxidative burst by distinct beta-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells SO GLYCOBIOLOGY LA English DT Article DE CR3; Dectin-1; human monocytes; oxidative burst; beta-glucan ID TYROSINE KINASE; CYTOKINE PRODUCTION; INFLAMMATORY RESPONSES; CANDIDA-ALBICANS; HUMAN NEUTROPHIL; DENDRITIC CELLS; HUMAN-MONOCYTES; LECTIN SITE; SYK KINASE; DECTIN-1 AB beta-Glucans possess broad immunomodulatory properties, including activation of innate immune functions such as oxidative burst activity. The differential roles of complement receptor type 3 (CR3) and Dectin-1, the known beta-glucan receptors, and their associated signaling pathways in the generation of oxidative burst induced by different physical forms of Saccharomyces cerevisiae-derived beta-glucan were examined in human peripheral blood mononuclear cells (PBMC). In this study whole glucan particle (WGP) or immobilized soluble beta-glucan (ISG) was used to represent the phagocytizable or the nonphagocytizable form of a fungus, respectively. Oxidative burst as measured by the formation of superoxide (SO) was detected in PBMC in response to WGP and ISG. SO induction with WGP was concluded to be Dectin-1-mediated and required Src family kinases, phosphatidylinositol-3 kinase and protein kinase B/Akt. In contrast, the SO induction generated by ISG was CR3-mediated and required focal adhesion kinase, spleen tyrosine kinase, phosphatidylinositol-3 kinase, Akt, p38 mitogen activated protein kinase, phospholipase C and protein kinase C. The study results support the hypothesis that human PBMC, specifically monocytes, utilize distinct receptors and overlapping, but distinct, signaling pathways for the oxidative burst in response to challenge by different physical forms of beta-glucan. C1 [Bose, Nandita; Wurst, Lindsay R.; Chan, Anissa S. H.; Dudney, Christine M.; LeRoux, Megan L.; Danielson, Michael E.; Will, Paul M.; Nodland, Sonja E.; Patchen, Myra L.; Vasilakos, John P.] Biothera, Eagan, MN 55121 USA. [Dalle Lucca, Jurandir J.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lebeda, Frank J.] US Army Med Res & Mat Command, Ft Detrick, MD 21701 USA. RP Bose, N (reprint author), Biothera, 3388 Mike Collins Dr, Eagan, MN 55121 USA. EM nbose@biothera.com FU Biothera FX N.B., L. R. W., A. S. H. C., M. E. D., P. M. W., S.E.N. and M. L. P., are employees of Biothera and are beneficiaries of the Biothera employee stock plan. C. M. D. and M. L. L. are former employees of Biothera. J.P.V. is a former employee of Biothera and currently receives consulting fees from Biothera. J.J.D.L. and F.J.L. have no competing interests. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. The mention of trade names, commercial products or organizations does not imply endorsement by the US Government. NR 57 TC 9 Z9 9 U1 0 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0959-6658 EI 1460-2423 J9 GLYCOBIOLOGY JI Glycobiology PD APR PY 2014 VL 24 IS 4 BP 379 EP 391 DI 10.1093/glycob/cwu005 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AD2ED UT WOS:000333045400006 PM 24440830 ER PT J AU Kalina, WV Douglas, CE Coyne, SR Minogue, TD AF Kalina, Warren Vincent Douglas, Christina Elizabeth Coyne, Susan Rajnik Minogue, Timothy Devin TI Comparative Assessment of Automated Nucleic Acid Sample Extraction Equipment for Biothreat Agents SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID REAL-TIME PCR; PURIFICATION; DNA; PLATFORMS AB Magnetic beads offer superior impurity removal and nucleic acid selection over older extraction methods. The performances of nucleic acid extraction of biothreat agents in blood or buffer by easyMAG, MagNA Pure, EZ1 Advanced XL, and Nordiag Arrow were evaluated. All instruments showed excellent performance in blood; however, the easyMAG had the best precision and versatility. C1 [Kalina, Warren Vincent; Douglas, Christina Elizabeth; Coyne, Susan Rajnik; Minogue, Timothy Devin] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil FU Joint Science & Technology Office for Chemical & Biological Defense [CB3901] FX This work was supported by the Joint Science & Technology Office for Chemical & Biological Defense under grant no. CB3901. NR 15 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2014 VL 52 IS 4 BP 1232 EP 1234 DI 10.1128/JCM.03453-13 PG 3 WC Microbiology SC Microbiology GA AC9CS UT WOS:000332832300035 PM 24452173 ER PT J AU Liu, NT Cancio, LC Salinas, J Batchinsky, AI AF Liu, Nehemiah T. Cancio, Leopoldo C. Salinas, Jose Batchinsky, Andriy I. TI Reliable real-time calculation of heart-rate complexity in critically ill patients using multiple noisy waveform sources SO JOURNAL OF CLINICAL MONITORING AND COMPUTING LA English DT Article DE Signal detection analysis; Electrocardiography; Heart rate; Clinical decision support systems; Machine learning; Automatic data processing ID QRS DETECTION; RATE-VARIABILITY; PHYSIOLOGICAL SIGNALS; NEONATAL SEPSIS; TRAUMA PATIENTS; EARLY-DIAGNOSIS; SAMPLE ENTROPY; FUSION; PREDICTION; ALGORITHM AB Heart-rate complexity (HRC) has been proposed as a new vital sign for critical care medicine. The purpose of this research was to develop a reliable method for determining HRC continuously in real time in critically ill patients using multiple waveform channels that also compensates for noisy and unreliable data. Using simultaneously acquired electrocardiogram (Leads I, II, V) and arterial blood pressure waveforms sampled at 360 Hz from 250 patients (over 375 h of patient data), we evaluated a new data fusion framework for computing HRC in real time. The framework employs two algorithms as well as signal quality indices. HRC was calculated (via the method of sample entropy), and equivalence tests were then performed. Bland-Altman plots and box plots of differences between mean HRC values were also obtained. Finally, HRC differences were analyzed by paired t tests. The gold standard for obtaining true means was manual verification of R waves and subsequent entropy calculations. Equivalence tests between mean HRC values derived from manually verified sequences and those derived from automatically detected peaks showed that the "Fusion" values were the least statistically different from the gold standard. Furthermore, the fusion of waveform sources produced better error density distributions than those derived from individual waveforms. The data fusion framework was shown to provide in real-time a reliable continuously streamed HRC value, derived from multiple waveforms in the presence of noise and artifacts. This approach will be validated and tested for assessment of HRC in critically ill patients. C1 [Liu, Nehemiah T.; Cancio, Leopoldo C.; Salinas, Jose; Batchinsky, Andriy I.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil FU U.S. Army Institute of Surgical Research Comprehensive Intensive Care Research Task Area; U.S. Army Combat Casualty Care Research Program FX This work was supported by the U.S. Army Institute of Surgical Research Comprehensive Intensive Care Research Task Area and the U.S. Army Combat Casualty Care Research Program. We would like to thank Mr. George B. Moody and Mr. Ken Pierce of PhysioNet for converting a rare printed copy of an MGH/MF Waveform Database patient guide into computer-readable form in order to make its contents available and searchable. NR 35 TC 2 Z9 2 U1 0 U2 4 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1387-1307 EI 1573-2614 J9 J CLIN MONIT COMPUT JI J. Clin. Monitor. Comp. PD APR PY 2014 VL 28 IS 2 BP 123 EP 131 DI 10.1007/s10877-013-9503-0 PG 9 WC Anesthesiology SC Anesthesiology GA AC8RB UT WOS:000332800200004 PM 23990286 ER PT J AU Lyle, DS Smith, JZ AF Lyle, David S. Smith, John Z. TI The Effect of High- Performing Mentors on Junior Officer Promotion in the US Army SO JOURNAL OF LABOR ECONOMICS LA English DT Article ID AFFIRMATIVE-ACTION; WEST POINT; PEER; HETEROGENEITY; INCENTIVES; EARNINGS AB Military assignment mechanisms provide a unique opportunity to estimate the impact of high-performing mentors on job advancement of their subordinates. Combining US Army administrative data with officer evaluation reports, we find that high-performing mentors positively affect early junior officer promotion and that early promotion probabilities rise as the duration of the high-quality mentorship increases. These effects are largest for high-ability proteegees. Junior officers who were exposed to multiple high-performing mentors did not experience an additional increase in promotion rates. C1 [Lyle, David S.; Smith, John Z.] US Mil Acad, West Point, NY 10996 USA. RP Smith, JZ (reprint author), US Mil Acad, West Point, NY 10996 USA. EM John.Smith2@usma.edu NR 33 TC 1 Z9 1 U1 1 U2 12 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0734-306X EI 1537-5307 J9 J LABOR ECON JI J. Labor Econ. PD APR 1 PY 2014 VL 32 IS 2 BP 229 EP 258 DI 10.1086/673372 PG 30 WC Economics; Industrial Relations & Labor SC Business & Economics GA AC6EU UT WOS:000332615100002 ER PT J AU Browning, RS Dinan, RJ Davidson, JS AF Browning, Robert S. Dinan, Robert J. Davidson, James S. TI Blast Resistance of Fully Grouted Reinforced Concrete Masonry Veneer Walls SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article; Proceedings Paper CT 10th International Conference on Shock and Impact Loads on Structures CY NOV 25-26, 2013 CL undefined, SINGAPORE DE Load factors; Explosions; Blasting; Structural dynamics; Full-scale tests; Masonry; Veneers; Walls; Extreme loading; Explosion; Blast; Structural dynamics; Experimental; Full-scale testing; Reinforced masonry; Multi-wythe walls; Cavity walls; Veneer walls ID FOAM CLADDINGS; ALLEVIATION; IMPACT; LOADS AB This paper describes the full-scale experimental evaluation of the out-of-plane flexural response of fully grouted RC masonry walls subjected to uniform static pressure and to dynamic pressure resulting from an explosion. The investigation was performed as part of a larger effort to improve the design methodologies for reinforced masonry subjected to blast loading. The masonry walls were non-load-bearing and vertically spanning, which represents a significant amount of common construction in the United States. Both single-wythe and veneer wall sections were evaluated. Two types of concrete masonry units were used, i.e., conventional and A-block concrete masonry units. The results of the program provide a better understanding of the ultimate dynamic capacities and ductility of reinforced masonry wallsboth single-wythe and veneer wallswhich will ultimately help engineers produce designs that are safer and more economical. C1 [Browning, Robert S.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Struct Mech Branch, CEERD GS M, Vicksburg, MS 39180 USA. [Dinan, Robert J.] US Air Force Civil Engn Ctr, Tyndall AFB, FL 32403 USA. [Dinan, Robert J.] Air Force Civil Engn Support Agcy, Tyndall AFB, FL 32403 USA. [Davidson, James S.] Auburn Univ, Dept Civil Engn, Auburn, AL 36849 USA. RP Browning, RS (reprint author), US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Struct Mech Branch, CEERD GS M, 3909 Halls Ferry Rd,Bldg 5008, Vicksburg, MS 39180 USA. EM robert.s.browning@usace.army.mil; jim.davidson@auburn.edu FU Airbase Technologies Division of the Air Force Research Laboratory (AFRL) at Tyndall Air Force Base, Florida; NCMA Education and Research Foundation Grant FX The experimental components of this project were sponsored by the Airbase Technologies Division of the Air Force Research Laboratory (AFRL) at Tyndall Air Force Base, Florida. The AFRL program manager during the experimental phase of this work was Dr. Robert Dinan. Experimental samples were provided through a Cooperative Research and Development Agreement (CRADA) with the Portland Cement Association (CRADA No. 05-119-ML-01). Dennis Graber from the National Concrete Masonry Association (NCMA) and Greg Borchelt from the Brick Industry Association assisted throughout the planning and execution of this program. Fig. 1 was provided by NCMA. The static experiments were conducted at the National Center of Explosive Research and Design, located at the University of Missouri-Columbia, under the supervision of Dr. Hani Salim and Aaron Saucier. Masonry material tests were conducted by NCMA. Employees of Applied Research Associates, Inc. contributed to the execution of the experimental program. Auburn University researchers in the Department of Civil Engineering, under the guidance of Dr. James Davidson, provided pre-test support of the experimental program, as well as post-test analysis of the experimental data, which was partially sponsored through an NCMA Education and Research Foundation Grant. While completing this paper, Robert Browning has been employed by the Geotechnical and Structures Laboratory (GSL) at the U. S. Army Engineer Research and Development Center in Vicksburg, Mississippi. Robert Browning is grateful for GSL's support in pursuing his Ph.D. and for the Director's approval to publish this paper. NR 57 TC 2 Z9 2 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 EI 1943-5509 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD APR 1 PY 2014 VL 28 IS 2 BP 228 EP 241 DI 10.1061/(ASCE)CF.1943-5509.0000434 PG 14 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA AC8FW UT WOS:000332769900004 ER PT J AU Hong, SS Yheulon, CG Wirtz, ED Sniezek, JC AF Hong, Steven S. Yheulon, Christopher G. Wirtz, Eric D. Sniezek, Joseph C. TI Otolaryngology and medical malpractice: A review of the past decade, 2001-2011 SO LARYNGOSCOPE LA English DT Article DE informed consent; Malpractice; lawsuit; legal; wrongful death ID EXPERT WITNESS; TONSILLECTOMY; LITIGATION; SURGERY; CANCER; CLAIMS; GLAND AB Objectives/Hypothesis To better understand the causes and outcomes of lawsuits involving otolaryngologists in the past decade by analyzing malpractice litigation trends to prevent future litigation and improve physician education. Study Design Analysis of a national database for all US civil trials. Methods The Westlaw database was reviewed from 2001 to 2011. Data were compiled on the demographics of the plaintiffs, use of expert witnesses, procedures, nature of the injury, legal allegations, verdicts, and indemnities. Results One hundred ninety-eight cases met inclusion criteria. Verdicts for the defendant/otolaryngologist predominated (58%), whereas the average award when the verdict favored the plaintiff was $1,782,514. When otolaryngologists were used as expert witnesses by the defense, the verdict outcome statistically favored the defendant. Two of the most commonly cited legal allegations were improper performance and failure to diagnose and treat. Fifty-one cases involved allegations of wrongful death, with the overall outcome favoring the plaintiffs (51%). The average indemnities in these cases were significantly higher for plaintiff verdicts at $2,552,580 versus settlements at $992,896. Forty-two cases involved malignancy, with the two most common allegations being failure to diagnose and treat (79%) and delay in diagnosis (74%). Conclusions Our study reveals that in the past decade, in significant malpractice litigations, overall outcomes favored otolaryngologists. The average awards was significantly higher when cases involved malignancy. Our analysis reveals the importance of meticulous surgical techniques and thorough preoperative evaluations. Last, when otolaryngologists are defendants in litigation, our review reiterates the value of the otolaryngologist as the defense's expert witnesses. Laryngoscope, 124:896-901, 2014 C1 [Hong, Steven S.; Yheulon, Christopher G.; Wirtz, Eric D.; Sniezek, Joseph C.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Hong, SS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM shongmd@gmail.com NR 26 TC 11 Z9 11 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD APR PY 2014 VL 124 IS 4 BP 896 EP 901 DI 10.1002/lary.24377 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA AD1AB UT WOS:000332965100025 PM 24105798 ER PT J AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. TI Performance of synthetic jet fuels in a meso-scale heat recirculating combustor SO APPLIED ENERGY LA English DT Article DE Alternative fuel; JP-8; Microcombustion; Heat recirculating combustor; Flame stability; Combustion characteristics ID SURROGATE FUEL AB The performance of two synthetic aviation fuels was evaluated in a meso-scale heat recirculating combustor and the respective results compared with the combustion characteristics of a conventional petroleum-based jet fuel. One of the alternative jet fuels was synthesized via a Fischer-Tropsch (F-.T fuel) process, while the other was produced from tallow (bin-jet fuel). The petroleum-based fuel used in this study was JP-8. The combustion and extinction behavior of the above fuels and their mixtures (50% synthetic fuel and 50% JP-8 by volume in JP-8) in the meso-scale combustor using oxygen under fuel-rich and fuel-lean non-premixed combustion conditions was examined. The synthetic fuels exhibited stable combustion over a range of equivalence ratios at each fuel flow rate; however, stable combustion was not achieved for JP-8 under any of the examined conditions. The mixtures also exhibited somewhat unstable combustion phenomena as those seen with JP-8, but dampened enough such that mostly stable combustion could occur. Fuel characterization analysis was performed for each fuel, and their respective thermal performances evaluated. Both the F-T and bio-jet fuels reached a maximum thermal efficiency of about 95% near their respective rich extinction limits. The mixtures exhibited somewhat poor thermal performances, with a maximum thermal efficiency of about 75%. The results reveal that composition of the fuel plays a prominent role in the flame stability and thermal performance in meso-scale combustors, as more complex species (such as aromatics, found in JP-8) have a slower reaction rate than simple species. The short residence time available in the combustion zone of the micro-combustion chamber does not allow to fully combust the complex fuel species, resulting in flame instability and formation of soot. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Wierzbicki, Teresa A.; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA. EM twierz@umd.edu; ivan.c.lee2.civ@mail.mil; akgupta@umd.edu FU U.S. Army Research Laboratory FX Research support provided to Teresa Wierzbicki by the U.S. Army Research Laboratory is gratefully acknowledged. Dr. Tim Edwards at the Air Force Research Laboratory is also acknowledged for supplying the alternative fuels investigated. Thanks are also due to Dr. Vivek Shirsat and Alexander Booth for all their help and support in various stages of this research and in the design and development of heat recirculating micro-combustors. NR 26 TC 10 Z9 11 U1 0 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD APR 1 PY 2014 VL 118 BP 41 EP 47 DI 10.1016/j.apenergy.2013.12.021 PG 7 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA AC3PZ UT WOS:000332435000005 ER PT J AU Klipp, C AF Klipp, Cheryl TI Turbulence Anisotropy in the Near-Surface Atmosphere and the Evaluation of Multiple Outer Length Scales SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Anisotropy; Buoyancy flux scales; CASES-99; Integral length scale; Outer length scale; Reynolds-stress tensor; Temperature variance scales; Turbulent kinetic energy ID BOUNDARY-LAYER; CASES-99 AB Length scales determined by maximum turbulent kinetic energy (TKE), the integral scale, and two length scales based on Reynolds stress-tensor anisotropy are compared to the often stated outer length scales of boundary-layer depth and distance from the earth's surface, . The scales are calculated using sonic anemometer data from two elevations, 5 and 50 m above the ground at the main tower site of the CASES-99 field campaign. In general, none of these scales agrees with the other, although the scale of maximum TKE is often similar to the boundary-layer depth during daytime hours, and the length scales derived from anisotropy characteristics are sometimes similar to , and depending on scale definition and thermal stability. Except for the scale with the strictest isotropy threshold, the turbulence is anisotropic for each of the various candidates for the outer scale. Length scales for maximum buoyancy flux and temperature variance are evaluated and the turbulence characteristics at these scales are almost always found to be anisotropic. C1 US Army Res Lab, RDRL CIE D, Adelphi, MD 20783 USA. RP Klipp, C (reprint author), US Army Res Lab, RDRL CIE D, Adelphi, MD 20783 USA. EM cheryl.l.klipp@us.army.mil FU National Science Foundation FX Thanks to Dr. Jiang Liu and Mr. David Tofsted of ARL for their helpful reviews. Thanks to the anonymous reviewers and the editor for the many questions and constructive comments. Thanks to the many participants of CASES-99 for the data which continue to yield new insights. CASES-99 data were provided by NCAR/EOL under sponsorship of the National Science Foundation. http://data.eol.ucar.edu/. NR 24 TC 0 Z9 0 U1 1 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 EI 1573-1472 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD APR PY 2014 VL 151 IS 1 BP 57 EP 77 DI 10.1007/s10546-013-9884-0 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AC5QH UT WOS:000332575100005 ER PT J AU Eshraghi, M Tschopp, MA Zaeem, MA Felicelli, SD AF Eshraghi, Mohsen Tschopp, Mark A. Zaeem, Mohsen Asle Felicelli, Sergio D. TI Effect of resistance spot welding parameters on weld pool properties in a DP600 dual-phase steel: A parametric study using thermomechanically-coupled finite element analysis SO MATERIALS & DESIGN LA English DT Article ID 6061-T6 ALUMINUM-ALLOY; CONTACT CONDITIONS; SIMULATION; SIZE; TRANSFORMATIONS; MICROSTRUCTURE; SHEETS AB The objective of this research is to quantify the effects of resistance spot welding (RSW) parameters on different weld properties of a dual-phase steel. A finite element based model was used which accounted for the following required physical interactions: the interaction between (1) the electro-kinetics and heat transfer via the Joule effect, (2) the heat transfer and phase transformations through latent heat, and (3) the heat transfer, electro-kinetics, and mechanical behavior via the contact conditions. The effects of the RSW parameters on weld properties were investigated within a design of experiments framework by altering (1) the electrical current intensity, (2) the welding time, (3) the sheet thickness, (3) the electrode face radius, and (5) the squeeze force at multiple levels. The simulation results were analyzed using the analysis of variance (ANOVA) technique to show the effects of these parameters and their potential interactions, along with their significance. The current intensity was the most influential factor and resulted in an increased size of molten zone and the heat affected zone. The sheet thickness and welding time also showed significant contributions in changing the weld properties. The effects of the other parameters were less significant. The importance of this study is that finding the optimal process window for RSW parameters can help to engineer the desired weld properties. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Eshraghi, Mohsen; Tschopp, Mark A.; Felicelli, Sergio D.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Eshraghi, Mohsen; Felicelli, Sergio D.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Tschopp, Mark A.] Army Res Lab, Mat & Mfg Sci Div, Lightweight & Specialty Met Branch, Aberdeen Proving Ground, MD 21005 USA. [Zaeem, Mohsen Asle] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. RP Eshraghi, M (reprint author), Univ Akron, Auburn Sci & Engn Ctr ASEC 101, Dept Mech Engn, Akron, OH 44325 USA. EM eshraghi@uakron.edu RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 FU Center for Advanced Vehicular Systems (CAVS) at Mississippi State University; U.S. Army Research Laboratory (ARL); U.S. Department of Energy; ARL FX We would like to acknowledge the sponsorship of the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University. We would also like to acknowledge the ESI group for providing the software license and Mr. Brian Shula for his support and the helpful discussions. MAT would like to acknowledge support from the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 33 TC 17 Z9 17 U1 4 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0261-3069 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD APR PY 2014 VL 56 BP 387 EP 397 DI 10.1016/j.matdes.2013.11.026 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA AB3WO UT WOS:000331721100051 ER PT J AU Kurinsky, RM Rochette, LM Smith, GA AF Kurinsky, Rachel M. Rochette, Lynne M. Smith, Gary A. TI Pediatric Injuries Associated With High Chairs and Chairs in the United States, 2003-2010 SO CLINICAL PEDIATRICS LA English DT Article DE injury; high chair; booster seat; chair; fall; child; infant AB This study describes the epidemiology of injuries among children 3 years old associated with high chairs compared with chairs by retrospectively analyzing data from the National Electronic Injury Surveillance System from 2003 to 2010. An estimated 402 479 (95% confidence interval = 335 116-469 842) injuries associated with high chairs and chairs were treated in United States emergency departments, with an average of 9421 high chair-related injuries and 40 889 chair-related injuries annually. The number of high chair-related injuries significantly increased by 22.4% from 8926 injuries in 2003 to 10 930 injuries in 2010. Falling was the most common injury mechanism associated with high chairs (92.8%) and chairs (87.3%). Closed head injury was the most common diagnosis associated with high chairs (37.3%), and increased in number (P = .005) and rate (P = .006) from 2003 to 2010. Child caregivers should properly engage high chair safety restraint systems and encourage appropriate behaviors by young children when using chairs. C1 [Kurinsky, Rachel M.; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Res Inst, Columbus, OH 43205 USA. [Kurinsky, Rachel M.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Rochette, Lynne M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [Smith, Gary A.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA. [Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA. RP Smith, GA (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, 700 Childrens Dr, Columbus, OH 43205 USA. EM gary.smith@nationwidechildrens.org FU National Medical Student Injury Research Training Program of the Center for Injury Research and Policy; Centers for Disease Control and Prevention [1R49CE001172] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: A student research scholarship was provided by the National Medical Student Injury Research Training Program of the Center for Injury Research and Policy and funded by the Centers for Disease Control and Prevention (grant# 1R49CE001172) to RMK while she worked on this study. NR 10 TC 8 Z9 9 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 EI 1938-2707 J9 CLIN PEDIATR JI Clin. Pediatr. PD APR PY 2014 VL 53 IS 4 BP 372 EP 379 DI 10.1177/0009922813510599 PG 8 WC Pediatrics SC Pediatrics GA AC0SU UT WOS:000332205900011 PM 24322954 ER PT J AU Schwacha, MG Rani, M Zhang, Q Nunez-Cantu, O Cap, AP AF Schwacha, Martin G. Rani, Meenakshi Zhang, Qiong Nunez-Cantu, Oliver Cap, Andre P. TI Mitochondrial damage-associated molecular patterns activate gamma delta T-cells SO INNATE IMMUNITY LA English DT Article DE Alarmins; trauma; Toll-like receptors; burn; cytokines ID INFLAMMATORY RESPONSE SYNDROME; CELLULAR MECHANISMS; THERMAL-INJURY; SELF ANTIGENS; UP-REGULATION; WOUND REPAIR; BURN INJURY; IN-VIVO; LYMPHOCYTES; EXPRESSION AB Gamma delta T-cells have been shown to be important in the early immunoinflammatory response to injury, which can be independent of infection. This sterile inflammatory response is believed to be, in part, associated with danger-associated molecular patterns (DAMPs). Mitochondrial DAMPs (MTDs) have been shown to be important in trauma-induced neutrophil activation, but it is unknown whether MTDs activate other innate immune cells, such as gamma delta T-cells. To study this, splenic CD3(+) gamma delta T-cells were isolated from alpha beta T-cell-deficient C57BL/6 mice and mitochondria isolated from wild type mouse livers. MTDs were isolated from mitochondria by sonication and centrifugation. Gamma delta T-cells were incubated with various concentrations of MTDs (0-500 mu g/ml) for 24 h. T-cells were phenotyped for TLR expression by flow cytometry and the supernatants assayed for cytokine and growth factor content. MTDs caused a dose-dependent increase in TLR2 and TLR4 expression by gamma delta T-cells. Both the percentage of cells positive for TLRs and the degree of expression increased. MTDs also induced the production of IL-1 beta, IL-6, IL-10, RANTES, fibroblast growth factor-basic and vascular endothelial growth factor by gamma delta T-cells. These findings support the concept that the MTDs released after tissue/cellular injury are capable of activating gamma delta T-cells, thus initiating sterile inflammation, as well as subsequent healing processes. C1 [Schwacha, Martin G.; Rani, Meenakshi; Zhang, Qiong; Nunez-Cantu, Oliver; Cap, Andre P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Schwacha, Martin G.; Cap, Andre P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM Schwacha@uthscsa.edu FU NIH [GM079122] FX Support was provided by NIH grant GM079122. NR 45 TC 12 Z9 12 U1 2 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1753-4259 EI 1753-4267 J9 INNATE IMMUN-LONDON JI Innate Immun. PD APR PY 2014 VL 20 IS 3 BP 261 EP 268 DI 10.1177/1753425913488969 PG 8 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA AC9GY UT WOS:000332843600004 PM 23757324 ER PT J AU Williams, KS Lenhart, JL Andzelm, JW Bandara, SV Baril, NF Henry, NC Tidrow, MZ AF Williams, Kristen S. Lenhart, Joseph L. Andzelm, Jan W. Bandara, Sumith V. Baril, Neil F. Henry, Nathan C. Tidrow, Meimei Z. TI First principles investigation of water adsorption and charge transfer on III-V(110) semiconductor surfaces SO SURFACE SCIENCE LA English DT Article DE Density functional theory; III-V semiconductor surfaces; GaAs(110); GaSb(110); InAs(110); Water adsorption ID DENSITY-FUNCTIONAL APPROXIMATIONS; AB-INITIO CALCULATIONS; ATOMIC GEOMETRY; COMPOUND SEMICONDUCTORS; ELECTRONIC-STRUCTURE; GAAS(110) SURFACES; III-V; 1ST-PRINCIPLES CALCULATIONS; MODEL EXPERIMENTS; SOLID-STATE AB We report a DFT/GGA study of water adsorption and charge transfer at the relaxed (110) surfaces of several III-V binary semiconductors: GaAs, GaSb, and InAs. Our calculations are the first to show that adsorption of dissociated water changes the (110) surface structure. The characteristic III-V bond rotation through an angle of 30 is reversed. The buckled III-V bond at the semiconductor/water interface rotates into the surface through a new angle, which we calculate to be approximately 11 degrees on all three binaries. Only dissociation of water - as opposed to chemisorption or physisorption - leads to this pseudo-unrelaxed configuration. We calculate geometries and reaction energies for several different adsorption mechanisms and find that molecular adsorption is the most favorable. We are able to reproduce binding configurations and energies for known adsorption sites on GaAs(110), but we also show new calculations for water on GaSb(110) and InAs(110). Lastly, we calculate the shift in electronic work function and induced surface dipole moment due to adsorbed water. We show that shifts in work function maximize at 1 ML of water, consistent with previous experimental works. Analysis of the partial charges and electron density reveals that adsorption of water polarizes the (110) surface, leading to local charge transfer across the semiconductor/water interface. Published by Elsevier BM. C1 [Williams, Kristen S.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Mat & Mfg Sci Div, MSTB Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Bandara, Sumith V.; Baril, Neil F.; Henry, Nathan C.; Tidrow, Meimei Z.] US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. [Baril, Neil F.; Henry, Nathan C.] Corbin Co, Alexandria, VA 22314 USA. RP Williams, KS (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, RDRL WMM G, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM kristen.s.williams7.ctr@mail.mil; joseph.l.lenhart.civ@mail.mil; jan.w.andzelm.civ@mail.mil; sumith.v.bandara.civ@mail.mil; neil.f.baril.ctr@mail.mil; nathan.c.henry3.ctr@mail.mil; meimei.z.tidrow.civ@mail.mil OI Henry, Nathan/0000-0002-7033-8467 FU CERDEC Director's Innovation Funding (CDIF) initiative; U.S. Army Research Laboratory; DOD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory DoD Supercomputing Resource Center FX K. Williams was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. This work was supported in part by a grant of computer time from the DOD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory DoD Supercomputing Resource Center. This project was further supported by the CERDEC Director's Innovation Funding (CDIF) initiative. NR 60 TC 6 Z9 6 U1 2 U2 45 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 EI 1879-2758 J9 SURF SCI JI Surf. Sci. PD APR PY 2014 VL 622 BP 71 EP 82 DI 10.1016/j.susc.2013.12.007 PG 12 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA AC0OP UT WOS:000332194900010 ER PT J AU Curtin, M Dwyer, S Bukvic, D Doona, CJ Kustin, K AF Curtin, Maria Dwyer, Sean Bukvic, Dino Doona, Christopher J. Kustin, Kenneth TI Kinetics and Mechanism of the Reduction of Sodium Chlorite by Sodium Hydrogen Ascorbate in Aqueous Solution at Near Neutral pH SO INTERNATIONAL JOURNAL OF CHEMICAL KINETICS LA English DT Article ID ELECTRON-TRANSFER-REACTIONS; AUTOXIDATION; OXIDATION; ANIONS; WATER; ACID AB The reduction of chlorite ion by the hydrogen ascorbate ion in a neutral solution safely produces chlorine dioxide. The decrease in absorbance at 268 nm with the presence of dimethyl sulfoxide (DMSO) allows measurement of the ascorbate disappearance in the reaction with excess chlorite. The measured rate constant at 25 +/- 0.02 degrees C, 3.67 x 10(-4) M DMSO, ionic strength 0.51 M (NaClO4), and in the presence of 3.32 x 10(-9) M ethylenediaminetetraacetic acid is 13.81 +/- 1.30 M-1 s(-1). Rate constant measurements over the range 15-35 degrees C gave an Arrhenius activation energy of 75.51 +/- 4.53 kJ mol(-1). This result is the first reported determination of the kinetics of this reaction and is consistent with either electron- or oxygen-transfer mechanisms. Anomalously, reduction of chlorite results in its oxidation, because intermediate hypochlorite oxidizes chlorite. C1 [Curtin, Maria; Dwyer, Sean; Bukvic, Dino] Stonehill Coll, Dept Chem, Easton, MA 02357 USA. [Doona, Christopher J.] US Army, Natick Soldier RDEC, Natick, MA 01760 USA. [Kustin, Kenneth] Brandeis Univ, Dept Chem, Waltham, MA 02453 USA. RP Curtin, M (reprint author), Stonehill Coll, Dept Chem, Easton, MA 02357 USA. EM mcurtin@stonehill.edu FU SURE program at Stonehill College; NSF-STEP grant [DUE-0622540]; Stonehill College Department of Chemistry FX The authors gratefully acknowledge the SURE program at Stonehill College for support of Sean Dwyer and NSF-STEP grant #DUE-0622540 and the Stonehill College Department of Chemistry for support of Dino Bukvic. NR 17 TC 2 Z9 2 U1 3 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0538-8066 EI 1097-4601 J9 INT J CHEM KINET JI Int. J. Chem. Kinet. PD APR PY 2014 VL 46 IS 4 BP 216 EP 219 DI 10.1002/kin.20847 PG 4 WC Chemistry, Physical SC Chemistry GA AB5AA UT WOS:000331800100003 ER PT J AU Zhang, K Fowler, M Glass, J Yin, H AF Zhang, Kai Fowler, Marcie Glass, Jonathan Yin, Hong TI Activated 5 ' Flanking Region ofNANOGP8 in a Self-Renewal Environment isAssociated with Increased Sphere Formation and Tumor Growth of Prostate Cancer Cells SO PROSTATE LA English DT Article DE NANOGP8; 5flanking region; stem cells; tumor growth ID HISTONE H3 ACETYLATION; STEM-CELLS; FACTOR STIMULATION; ALU REPEATS; GENE NANOG; PLURIPOTENCY; EXPRESSION; PROMOTES; BINDING; PROLIFERATION AB INTRODUCTION NANOGP8 is a retrogene which encodes a full-length protein similar to the NANOG1 gene. The expression of NANOGP8 has been documented in several cancers and is related to cell proliferation and tumor development. However, the regulation of NANOGP8 expression has not been investigated. Therefore, the role of NANOGP8 in cell proliferation has not been completely understood. METHODSWe evaluate the expression of NANOG1 and NANOGP8 in prostate cancer cell lines and primary cultures of prostate tissues. We investigate clonogenicity, sphere formation, and xenograft tumor growth of prostate cancer cells with an activated 5flanking region of NANOGP8. We examine the role of NANOGP8 in cell cycle progression. RESULTSIn the prostate cells the NANOG RNA was transcribed from NANOGP8 and not from NANOG1. Cells with the activated 5flanking region of NANOGP8 exhibited enhanced clonogenicity, sphere formation, and xenograft tumor growth. The sphere culture and tumor initiation mouse mode promoted the activation of the 5flanking region of NANOGP8. Forced expression of NANOGP8 increased the entry into the cell cycle. DISCUSSIONIn prostate cells NANOGP8 is a predominant molecule of NANOG. The activation of 5flanking sequence of NANOGP8 could play a role in the regulation of the stem-like properties of cancer stem cells and prostate tumor initiation and development. The microenvironment favoring cancer stem cells could promote the activation of the 5flanking region of NANOGP8. Prostate 74:381-394, 2014. (c) 2013 Wiley Periodicals, Inc. C1 [Zhang, Kai; Glass, Jonathan; Yin, Hong] LSUHSC Shreveport, Feist Weiller Canc Ctr, Shreveport, LA 71130 USA. [Fowler, Marcie] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. RP Yin, H (reprint author), LSUHSC Shreveport, Feist Weiller Canc Ctr, 1501 Kings Highway, Shreveport, LA 71130 USA. EM hyin@lsuhsc.edu FU Feist-Weiller Cancer Center Louisiana State University Health Sciences Center Shreveport LA FX Grant sponsor: Feist-Weiller Cancer Center Louisiana State University Health Sciences Center Shreveport LA. NR 34 TC 6 Z9 7 U1 2 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-4137 EI 1097-0045 J9 PROSTATE JI Prostate PD APR PY 2014 VL 74 IS 4 BP 381 EP 394 DI 10.1002/pros.22759 PG 14 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA 292BY UT WOS:000329878100006 PM 24318967 ER PT J AU Wei, XM Ai, JM Deng, YP Guan, X Johnson, DR Ang, CY Zhang, CY Perkins, EJ AF Wei, Xiaomou Ai, Junmei Deng, Youping Guan, Xin Johnson, David R. Ang, Choo Y. Zhang, Chaoyang Perkins, Edward J. TI Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles SO BMC GENOMICS LA English DT Article DE Biomarker; Microarray; Hepatocytes; Chemical; Classification ID NF-KAPPA-B; MICROARRAY DATA; IN-VITRO; CLASSIFICATION METHODS; UNDERSTAND MECHANISMS; LOGISTIC-REGRESSION; CANCER-DIAGNOSIS; TOXICITY; SELECTION; LIVER AB Background: High throughput transcriptomics profiles such as those generated using microarrays have been useful in identifying biomarkers for different classification and toxicity prediction purposes. Here, we investigated the use of microarrays to predict chemical toxicants and their possible mechanisms of action. Results: In this study, in vitro cultures of primary rat hepatocytes were exposed to 105 chemicals and vehicle controls, representing 14 compound classes. We comprehensively compared various normalization of gene expression profiles, feature selection and classification algorithms for the classification of these 105 chemicals into14 compound classes. We found that normalization had little effect on the averaged classification accuracy. Two support vector machine (SVM) methods, LibSVM and sequential minimal optimization, had better classification performance than other methods. SVM recursive feature selection (SVM-RFE) had the highest overfitting rate when an independent dataset was used for a prediction. Therefore, we developed a new feature selection algorithm called gradient method that had a relatively high training classification as well as prediction accuracy with the lowest overfitting rate of the methods tested. Analysis of biomarkers that distinguished the 14 classes of compounds identified a group of genes principally involved in cell cycle function that were significantly downregulated by metal and inflammatory compounds, but were induced by anti-microbial, cancer related drugs, pesticides, and PXR mediators. Conclusions: Our results indicate that using microarrays and a supervised machine learning approach to predict chemical toxicants, their potential toxicity and mechanisms of action is practical and efficient. Choosing the right feature and classification algorithms for this multiple category classification and prediction is critical. C1 [Wei, Xiaomou] Guangxi Med Univ, Hosp 4, Dept Lab Sci, Liuzhou, Peoples R China. [Wei, Xiaomou; Ai, Junmei; Deng, Youping] Rush Univ, Med Ctr, Ctr Canc, Dept Internal Med, Chicago, IL 60612 USA. [Guan, Xin; Ang, Choo Y.] SpecPro Inc, Vicksburg, MS 39180 USA. [Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Johnson, David R.] Conestoga Rovers & Associates, Dallas, TX 75234 USA. [Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. RP Deng, YP (reprint author), Rush Univ, Med Ctr, Ctr Canc, Dept Internal Med, Kidston House,630 S Hermitage Ave Room 408, Chicago, IL 60612 USA. EM youping_deng@rush.edu FU US Army Environmental Quality Program [W912HZ-05-P-0145] FX This project was supported by US Army Environmental Quality Program (contract #W912HZ-05-P-0145). Permission was granted by the Chief of Engineers to publish this information. NR 54 TC 9 Z9 9 U1 2 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD MAR 31 PY 2014 VL 15 AR 248 DI 10.1186/1471-2164-15-248 PG 17 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AF8GJ UT WOS:000334953400001 PM 24678894 ER PT J AU Kaplan, D Recine, G Swaminathan, V AF Kaplan, D. Recine, G. Swaminathan, V. TI Electrically dependent bandgaps in graphene on hexagonal boron nitride SO APPLIED PHYSICS LETTERS LA English DT Article ID EPITAXIAL GRAPHENE; GROWTH; LAYERS AB We present first-principles calculations on the bandgap of graphene on a layer of hexagonal boron nitride in three different stacking configurations. Relative stability of the configurations is identified and bandgap tunability is demonstrated through the application of an external, perpendicularly applied electric field. We carefully examine the bandgap's sensitivity to both magnitude of the applied field as well as separation between the graphene and hexagonal boron nitride layers. Features of the band structure are examined and configuration-dependent relationships between the field and bandgap are revealed and elucidated through the atom-projected density of states. These findings suggest the potential for opening and modulating a bandgap in graphene as high as several hundred meV. (C) 2014 AIP Publishing LLC. C1 [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. [Recine, G.] Polytech Inst New York, Dept Appl Phys, Brooklyn, NY 11201 USA. [Recine, G.] Fordham Univ, Dept Phys & Engn Phys, Bronx, NY 10458 USA. RP Kaplan, D (reprint author), US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. EM daniel.b.kaplan.civ@mail.mil FU U.S. Army's Armament Research Development and Engineering Center [W15QKN-11-P-0142] FX The work at NYU-Poly/Fordham University was performed under support from the U.S. Army's Armament Research Development and Engineering Center under Contract No. W15QKN-11-P-0142. NR 27 TC 3 Z9 3 U1 3 U2 39 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 31 PY 2014 VL 104 IS 13 AR 133108 DI 10.1063/1.4870769 PG 5 WC Physics, Applied SC Physics GA AF0MK UT WOS:000334408500059 ER PT J AU Lao, YF Perera, AGU Wijewarnasuriya, PS AF Lao, Yan-Feng Perera, A. G. Unil Wijewarnasuriya, Priyalal S. TI Optical study of HgCdTe infrared photodetectors using internal photoemission spectroscopy SO APPLIED PHYSICS LETTERS LA English DT Article ID ABSORPTION; HG1-XCDXTE AB We report a study of internal photoemission spectroscopy (IPE) applied to a n-type Hg1-xCdxTe/Hg1-yCdyTe heterojunction. An exponential line-shape of the absorption tail in HgCdTe is identified by IPE fittings of the near-threshold quantum yield spectra. The reduction of quantum yield (at higher photon energy) below the fitting value is explained as a result of carrier-phonon scatterings. In addition, the obtained bias independence of the IPE threshold indicates a negligible electron barrier at the heterojunction interface. (C) 2014 AIP Publishing LLC. C1 [Lao, Yan-Feng; Perera, A. G. Unil] Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. [Wijewarnasuriya, Priyalal S.] US Army Res Lab, Adelphi, MD 20783 USA. RP Perera, AGU (reprint author), Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. EM uperera@gsu.edu OI Lao, Yanfeng/0000-0002-6301-9417 FU U.S. Army Research Office [W911NF-12-2-0035]; U.S. National Science Foundation [ECCS-1232184] FX This work was supported in part by the U.S. Army Research Office under Grant No. W911NF-12-2-0035 monitored by Dr. William W. Clark, and in part by the U.S. National Science Foundation under Grant No. ECCS-1232184. NR 13 TC 3 Z9 3 U1 1 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 31 PY 2014 VL 104 IS 13 AR 131106 DI 10.1063/1.4870479 PG 3 WC Physics, Applied SC Physics GA AF0MK UT WOS:000334408500006 ER PT J AU Perovich, D Richter-Menge, J Polashenski, C Elder, B Arbetter, T Brennick, O AF Perovich, Don Richter-Menge, Jacqueline Polashenski, Chris Elder, Bruce Arbetter, Todd Brennick, Owen TI Sea ice mass balance observations from the North Pole Environmental Observatory SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article DE Arctic sea ice; mass balance; summer melt ID COVER; THICKNESS; IMPACT; MELT AB In recent years the periphery of the Arctic sea ice cover has undergone significant changes, with a reduction in summer ice extent, a thinning of the ice, and a shift from multiyear to first year ice. Here we examine sea ice conditions during nine summers between 2000 and 2013 in the interior of the ice pack, using autonomous measurements of sea ice mass balance deployed near the North Pole. Results exhibit no definitive trends. There is large interannual variability, with surface melt ranging from 0.02m to 0.50m and bottom melt from 0.10m to 0.57m. The largest amounts of bottom melt have occurred in the past few years. For all 9 years the ice at the end of the melt season was at least 1.2m thick. C1 [Perovich, Don; Richter-Menge, Jacqueline; Polashenski, Chris; Elder, Bruce; Brennick, Owen] ERDC CRREL, Hanover, NH 03755 USA. [Perovich, Don; Polashenski, Chris] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Arbetter, Todd] Brown Univ, Environm Change Initiat, Providence, RI 02912 USA. RP Perovich, D (reprint author), ERDC CRREL, Hanover, NH 03755 USA. EM donald.k.perovich@usace.army.mil FU National Science Foundation; National Oceanic and Atmospheric Administration; International Arctic Buoy Programme FX This work has been supported by the National Science Foundation, the National Oceanic and Atmospheric Administration, and the International Arctic Buoy Programme. We acknowledge and appreciate the gracious support of the North Pole Environmental Observatory, the Polar Science Center, University of Washington, and the Woods Hole Oceanographic Institute in the deployment of the autonomous ice mass balance buoys. Thank you to the Editor and two anonymous reviewers for their helpful suggestions. All data used in this paper are available from the author, and basic data are also available from the website http://imb.crrel.usace.army.mil/. NR 36 TC 13 Z9 14 U1 3 U2 15 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD MAR 28 PY 2014 VL 41 IS 6 BP 2019 EP 2025 DI 10.1002/2014GL059356 PG 7 WC Geosciences, Multidisciplinary SC Geology GA AE8PX UT WOS:000334264900028 ER PT J AU Miller, OD Hsu, CW Reid, MTH Qiu, W DeLacy, BG Joannopoulos, JD Soljacic, M Johnson, SG AF Miller, O. D. Hsu, C. W. Reid, M. T. H. Qiu, W. DeLacy, B. G. Joannopoulos, J. D. Soljacic, M. Johnson, S. G. TI Fundamental Limits to Extinction by Metallic Nanoparticles SO PHYSICAL REVIEW LETTERS LA English DT Article ID 2-COMPONENT COMPOSITE-MATERIAL; BROAD-BAND SCATTERING; PHYSICAL LIMITATIONS; DIELECTRIC-CONSTANT; OPTICAL-PROPERTIES; SMALL PARTICLES; ASPECT-RATIO; SUM-RULES; ABSORPTION; SHAPE AB We show that there are shape-independent upper bounds to the extinction cross section per unit volume of dilute, randomly arranged nanoparticles, given only material permittivity. Underlying the limits are restrictive sum rules that constrain the distribution of quasistatic eigenvalues. Surprisingly, optimally designed spheroids, with only a single quasistatic degree of freedom, reach the upper bounds for four permittivity values. Away from these permittivities, we demonstrate computationally optimized structures that surpass spheroids and approach the fundamental limits. C1 [Miller, O. D.; Reid, M. T. H.; Johnson, S. G.] MIT, Dept Math, Cambridge, MA 02139 USA. [Hsu, C. W.; Qiu, W.; Joannopoulos, J. D.; Soljacic, M.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Hsu, C. W.] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. [DeLacy, B. G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Miller, OD (reprint author), MIT, Dept Math, Cambridge, MA 02139 USA. EM odmiller@math.mit.edu RI Hsu, Chia Wei/G-5486-2011 OI Hsu, Chia Wei/0000-0002-9609-7155 FU Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-07-D0004]; University Research Initiative (MURI) for Complex and Robust Onchip Nanophotonics [FA9550-09-1-0704] FX This work was supported by the Army Research Office through the Institute for Soldier Nanotechnologies under Contract No. W911NF-07-D0004, and by the AFOSR Multidisciplinary Research Program of the University Research Initiative (MURI) for Complex and Robust Onchip Nanophotonics under Grant No. FA9550-09-1-0704. NR 63 TC 13 Z9 13 U1 0 U2 34 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 26 PY 2014 VL 112 IS 12 AR 123903 DI 10.1103/PhysRevLett.112.123903 PG 5 WC Physics, Multidisciplinary SC Physics GA AE4AP UT WOS:000333920000017 PM 24724651 ER PT J AU Zhu, HL Lee, KT Hitz, GT Han, XG Li, YY Wan, JY Lacey, S Cresce, AV Xu, K Wachsman, E Hu, LB AF Zhu, Hongli Lee, Kang Taek Hitz, Gregory Thomas Han, Xiaogang Li, Yuanyuan Wan, Jiayu Lacey, Steven Cresce, Arthur von Wald Xu, Kang Wachsman, Eric Hu, Liangbing TI Free-Standing Na2/3Fe1/2Mn1/2O2@Graphene Film for a Sodium-Ion Battery Cathode SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE Na-ion battery cathode; Na2/3Fe1/2Mn1/2O2; graphene; free-standing; electrolyte; binder-free ID RECHARGEABLE NA BATTERIES; ENERGY-STORAGE; HIGH-CAPACITY; ANODE MATERIAL; ELECTROLYTE; PERFORMANCE; INSERTION; MECHANISM AB The development of high-performance cathodes for sodium-ion batteries remains a great challenge, while low-cost, high-capacity Na2/3Fe1/2Mn1/2O2 is an attractive electrode material candidate comprised of earth-abundant elements. In this work, we designed and fabricated a free-standing, binder-free Na2/3Fe1/2Mn1/2O2@graphene composite via a filtration process. The porous composite led to excellent electrochemical performance due to the facile transport for electrons and ions that was characterized by electrochemical impedance spectroscopy at different temperatures. The electrode delivered a reversible capacity of 156 mAh/g with high Coulombic efficiency. The importance of a fluorinated electrolyte additive with respect to the performance of this high-voltage cathode in Na-ion batteries was also investigated. C1 [Zhu, Hongli; Lee, Kang Taek; Hitz, Gregory Thomas; Han, Xiaogang; Li, Yuanyuan; Wan, Jiayu; Lacey, Steven; Wachsman, Eric; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Lee, Kang Taek] DGIST, Dept Energy Syst Engn, Taegu 711873, South Korea. [Cresce, Arthur von Wald; Xu, Kang] US Army Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil; ewach@umd.edu; binghu@umd.edu RI Hu, Liangbing/N-6660-2013; Han, Xiaogang/D-6430-2015 OI Han, Xiaogang/0000-0002-4785-6506 FU University of Maryland; Maryland Nanocenter; Fablab; Nisplab FX L.H. acknowledges the startup support from the University of Maryland. We acknowledge the support of the Maryland Nanocenter as well as its Fablab and Nisplab. NR 36 TC 29 Z9 29 U1 7 U2 183 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAR 26 PY 2014 VL 6 IS 6 BP 4242 EP 4247 DI 10.1021/am405970s PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA AD8YL UT WOS:000333551500061 PM 24588793 ER PT J AU Roy, D Mahesh, BV Atwater, MA Chan, TE Scattergood, RO Koch, CC AF Roy, D. Mahesh, B. V. Atwater, M. A. Chan, T. E. Scattergood, R. O. Koch, C. C. TI Grain size stability and hardness in nanocrystalline Cu-Al-Zr and Cu-Al-Y alloys SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Cryomilling; Nanocrystalline; Thermal stabilization; Cu-Al alloys ID STABILIZATION; SEGREGATION; NANOSTRUCTURES; GROWTH AB Cryogenic high energy ball milling has been used to synthesize nanocrystalline Cu-14Al, Cu-12Al-2Zr and Cu-12Al-2Y alloys by mechanical alloying. The alloys were studied with the aim of comparing the effect of substituting Y and Zr in place of Al, in Cu-Al alloys, on the grain size stability at elevated temperatures. The as-milled alloys were subjected to annealing at various temperatures between 200 and 900 degrees C and the resulting grain morphology has been studied using X-ray diffraction and transmission electron microscopy. The addition of Y results in significantly reduced susceptibility to grain growth whereas in case of CuAl and CuAlZr alloys, the susceptibility to grain growth was much higher. The hardness is substantially increased due to Zr and Y addition in the as-milled CuAl powders. However, the hardness of Cu-12Al-2Zr gradually decreases and approaches that of Cu-14Al alloy after the annealing treatment whereas in case of Cu-12Al-2Y alloy, the relative drop in the hardness is much lower after annealing. Accordingly, the efficacy of grain size stabilization by Y addition at high homologous temperatures has been explained on the basis of a recent thermodynamic stabilization models. (C) 2013 Elsevier B.V. All rights reserved. C1 [Roy, D.; Chan, T. E.; Scattergood, R. O.; Koch, C. C.] N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27606 USA. [Roy, D.] NIFFT, Mat & Met Engn Dept, Ranchi 834003, Bihar, India. [Mahesh, B. V.] Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia. [Atwater, M. A.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Roy, D (reprint author), N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27606 USA. EM droy2k6@gmail.com FU Indo-US Science and Technology Forum, Govt. of India [IUSSTF Fellowship/2011/8]; US office of Naval Research [N00014-10-1-0168] FX The work was sponsored by the Indo-US Science and Technology Forum, Govt. of India, under the grant of Indo-US fellowship No IUSSTF Fellowship/2011/8 dated 17/3/2011 and the US office of Naval Research under Grant no. N00014-10-1-0168. NR 27 TC 6 Z9 6 U1 2 U2 22 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAR 26 PY 2014 VL 598 BP 217 EP 223 DI 10.1016/j.msea.2013.11.075 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AE1ZF UT WOS:000333772400025 ER PT J AU Ranaallo, RT Kaminski, R Baqar, S Dutta, M Lugo-Roman, LA Boren, T Barnoy, S Venkatesan, MM AF Ranaallo, R. T. Kaminski, R. Baqar, S. Dutta, M. Lugo-Roman, L. A. Boren, T. Barnoy, S. Venkatesan, M. M. TI Oral administration of live Shigella vaccine candidates in rhesus monkeys show no evidence of competition for colonization and immunogenicity between different serotypes SO VACCINE LA English DT Article DE Shigella; Live bivalent vaccine candidates; Rhesus monkeys; Colonization; Immunogenicity ID O-SPECIFIC POLYSACCHARIDE; FLEXNERI 2A; SONNEI; SAFETY; INFECTION; STRAINS; MODEL; WRSS1; BANGLADESH; ANTIGENS AB Live oral monovalent Shigella flexneri 2a vaccine candidates as well as bivalent formulations with Shigella sonnei were evaluated in a rhesus monkey model for colonization and immunogenicity. Freshly harvested suspensions of S. flexneri 2a vaccine candidates WRSf2G12 and WRSf2G15 as well as S. sonnei vaccine candidate WRSs3 were nasogastrically administered to groups of rhesus monkeys, Macaca mulatto, either in a monovalent form or when combined with each other. The animals were monitored daily for physical well-being, stools were subjected to quantitative colony immunoblot assays for bacterial excretion and blood and stools were evaluated for humoral and mucosal immune responses. No clinical symptoms were noted in any group of animals and the vaccine candidates were excreted robustly for 48-72 h without significant changes in either the magnitude or duration of excretion when given as a monovalent or as bivalent mixtures. Similarly, immunological interferences were not apparent in the magnitude of humoral and mucosal immune responses observed toward Shigella-specific antigens when monkeys were fed monovalent or bivalent formulations. These results predict that a multivalent live oral vaccine of more than one serotype can have a favorable outcome for protection against shigellosis. Published by Elsevier Ltd. C1 [Ranaallo, R. T.; Kaminski, R.; Dutta, M.; Boren, T.; Barnoy, S.; Venkatesan, M. M.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Baqar, S.] NMRC, Enter Dis Branch, Silver Spring, MD 20910 USA. [Lugo-Roman, L. A.] Walter Reed Army Inst Res, Dept Vet Med, Silver Spring, MD 20910 USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Malabi.venkatesan@us.army.mil NR 24 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 26 PY 2014 VL 32 IS 15 BP 1754 EP 1760 DI 10.1016/j.vaccine.2013.12.068 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AE1ZH UT WOS:000333772600016 PM 24522159 ER PT J AU Ross, RB Ahmad, R Brennan, JK Frankel, KA Moore, JD Moore, JD Mountain, RD Shen, VK Schultz, NE Siderius, DW Smith, KD Thommes, M AF Ross, Richard B. Ahmad, Riaz Brennan, John K. Frankel, Kevin A. Moore, Jonathan D. Moore, Joshua D. Mountain, Raymond D. Shen, Vincent K. Schultz, Nathan E. Siderius, Daniel W. Smith, Kenneth D. Thommes, Matthias TI The seventh industrial fluid properties simulation challenge SO FLUID PHASE EQUILIBRIA LA English DT Article DE Perfluorohexane; Adsorption; BCR-704 zeolite; Molecular simulation; Monte Carlo simulation ID MONTE-CARLO SIMULATIONS; VAPOR-LIQUID-EQUILIBRIA; MOLECULAR-DYNAMICS SIMULATION; GLYCOL DIMETHYL ETHER; BUBBLE POINT PRESSURE; HENRYS LAW CONSTANTS; FORCE-FIELD; ETHYLENE-OXIDE; ESTABLISHING BENCHMARKS; BINARY-MIXTURES AB The goal of the seventh industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in zeolite materials. Zeolite adsorbents are used in a variety of applications due to their high surface area and abilities to adsorb or desorb sorbates depending upon the applied conditions. With increasing numbers of applications, the ability to predict the performance of zeolites for a wide range of adsorbates would be very valuable in pre-optimizing systems and reducing product development time. The seventh challenge focused, in particular, on the adsorption of perfluorohexane in BCR-704 Faujasite Zeolite. Entrants were challenged to predict the adsorption of perfluorohexane in the zeolite at 293 K and at relative pressures of 0.01, 0.05, 0.1, 0.2, 0.4, 0.6, and 0.8. The relative pressure is defined as that relative to the bulk saturation pressure predicted by the model at a given temperature (293 K in this case). The predictions were judged by comparison to a benchmark set of experimentally determined values. Overall good agreement and consistency were found between the predictions of most entrants. (C) 2013 Elsevier B.V. All rights reserved. C1 [Ross, Richard B.; Frankel, Kevin A.; Schultz, Nathan E.] 3M Co, St Paul, MN 55144 USA. [Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA. [Brennan, John K.; Moore, Joshua D.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA. [Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA. [Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA. RP Ross, RB (reprint author), 3M Co, 201-2E-23, St Paul, MN 55144 USA. EM rbross@mmm.com RI Siderius, Daniel/E-8116-2011; Moore, Jonathan/B-8201-2009 OI Siderius, Daniel/0000-0002-6260-7727; FU 3M Company; BP Amoco; Dow Chemical Company; DuPont; Exxon Mobil; Mitsubishi Chemical Corporation FX We would like to thank the Computational Molecular Science and Engineering Forum (CoMSEF) of the American Institute of Chemical Engineers and the Physical Chemistry Division of the American Chemical Society (ACS) for their institutional support. We would also like to thank the 3M Company, BP Amoco, The Dow Chemical Company, DuPont, Exxon Mobil, and Mitsubishi Chemical Corporation for financial support. In addition, we thank Quantachrome Instruments for carrying out the benchmark experimental adsorption studies. We would also like to thank the anonymous committee of academic modeling experts who served as external judges for the challenge. Finally, we would like to thank all the participants for their willingness to commit considerable time and resources to this challenge and for participating in the valuable discussions during the challenge symposium at the AIChE annual meeting. NR 64 TC 2 Z9 2 U1 3 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 EI 1879-0224 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD MAR 25 PY 2014 VL 366 BP 136 EP 140 DI 10.1016/j.fluid.2013.09.062 PG 5 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA AE6GU UT WOS:000334089400016 ER PT J AU Ross, RB Brennan, JK Frankel, KA Moore, JD Moore, JD Mountain, RD Ahmad, R Thommes, M Shen, VK Schultz, NE Siderius, DW Smith, KD AF Ross, Richard B. Brennan, John K. Frankel, Kevin A. Moore, Jonathan D. Moore, Joshua D. Mountain, Raymond D. Ahmad, Riaz Thommes, Matthias Shen, Vincent K. Schultz, Nathan E. Siderius, Daniel W. Smith, Kenneth D. TI Perfluorohexane adsorption in BCR-704 Faujasite zeolite benchmark studies for the seventh industrial fluid properties simulation challenge SO FLUID PHASE EQUILIBRIA LA English DT Article DE Perfluorohexane; Adsorption; BCR-704 zeolite AB The primary goal of the seventh industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in zeolitic materials. The challenge focused, in particular, on the adsorption of perfluorohexane in the BCR-704 Faujasite zeolite. Entrants were challenged to predict the adsorption of perfluorohexane in the zeolite at 293 K and at relative pressures of 0.01, 0.05, 0.1, 0.2, 0.4, 0.6, and 0.8. The relative pressure (P/P-o) is defined as that relative to the bulk saturation pressure predicted by the model at a given temperature (293 K in this case). The predictions were judged by comparison to a set of experimentally determined values which are published here for the first time and were not disclosed prior to the challenge to the entrants. Additional benchmark experimental studies, also described here-in, were carried out and provided to entrants in order to aid in the development of new force fields and simulation methods to be employed in the challenge. These studies included argon and nitrogen adsorption in the BCR-704 Faujasite zeolite. Elemental analysis of the BCR-704 Faujasite type zeolite was also available to entrants via the Institute of Reference Materials and Measurement (IRMM) report EUR 21065 [1]. (C) 2014 Elsevier B.V. All rights reserved. C1 [Ross, Richard B.; Frankel, Kevin A.; Schultz, Nathan E.] 3M Co, St Paul, MN 55144 USA. [Brennan, John K.; Moore, Joshua D.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA. [Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA. [Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA. [Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA. RP Ross, RB (reprint author), 3M Co, 201-2E-23, St Paul, MN 55144 USA. EM rbross@mmm.com RI Siderius, Daniel/E-8116-2011; Moore, Jonathan/B-8201-2009 OI Siderius, Daniel/0000-0002-6260-7727; NR 12 TC 2 Z9 2 U1 3 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 EI 1879-0224 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD MAR 25 PY 2014 VL 366 BP 141 EP 145 DI 10.1016/j.fluid.2013.12.025 PG 5 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA AE6GU UT WOS:000334089400017 ER PT J AU Lon, C Manning, JE Vanachayangkul, P So, M Sea, D Se, Y Gosi, P Lanteri, C Chaorattanakawee, S Sriwichai, S Chann, S Kuntawunginn, W Buathong, N Nou, S Walsh, DS Tyner, SD Juliano, JJ Lin, J Spring, M Bethell, D Kaewkungwal, J Tang, D Chuor, CM Satharath, P Saunders, D AF Lon, Chanthap Manning, Jessica E. Vanachayangkul, Pattaraporn So, Mary Sea, Darapiseth Se, Youry Gosi, Panita Lanteri, Charlotte Chaorattanakawee, Suwanna Sriwichai, Sabaithip Chann, Soklyda Kuntawunginn, Worachet Buathong, Nillawan Nou, Samon Walsh, Douglas S. Tyner, Stuart D. Juliano, Jonathan J. Lin, Jessica Spring, Michele Bethell, Delia Kaewkungwal, Jaranit Tang, Douglas Chuor, Char Meng Satharath, Prom Saunders, David TI Efficacy of Two versus Three-Day Regimens of Dihydroartemisinin-Piperaquine for Uncomplicated Malaria in Military Personnel in Northern Cambodia: An Open-Label Randomized Trial SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; IN-VITRO; SOUTHEAST-ASIA; RESISTANCE; PFMDR1; THAILAND; SAFETY; PHARMACOKINETICS; MUTATIONS; ASSAY AB Introduction: Emerging antimalarial drug resistance in mobile populations remains a significant public health concern. We compared two regimens of dihydroartemisinin-piperaquine in military and civilians on the Thai-Cambodian border to evaluate national treatment policy. Methods: Efficacy and safety of two and three-day regimens of dihydroartemisinin-piperaquine were compared as a nested open-label evaluation within a malaria cohort study in 222 otherwise healthy volunteers (18% malaria-infected at baseline). The first 80 volunteers with slide-confirmed Plasmodium falciparum or vivax malaria were randomized 1: 1 to receive either regimen (total dose 360mg dihydroartemisinin and 2880mg piperaquine) and followed weekly for up to 6 months. The primary endpoint was malaria recurrence by day 42. Volunteers with vivax infection received primaquine at study discharge with six months follow-up. Results: Eighty patients (60 vivax, 15 falciparum, and 5 mixed) were randomized to dihydroartemisinin-piperaquine. Intention-to-treat all-species efficacy at Day 42 was 85% for the two-day regimen (95% CI 69-94) and 90% for the three-day regimen (95% CI 75-97). PCR-adjusted falciparum efficacy was 75% in both groups with nearly half (45%) still parasitemic at Day 3. Plasma piperaquine levels were comparable to prior published reports, but on the day of recrudescence were below measurable in vitro piperaquine IC50 levels in all falciparum treatment failures. Conclusions: In the brief period since introduction of dihydroartemisinin-piperaquine, there is early evidence suggesting declining efficacy relative to previous reports. Parasite IC50 levels in excess of plasma piperaquine levels seen only in treatment failures raises concern for clinically significant piperaquine resistance in Cambodia. These findings warrant improved monitoring of clinical outcomes and follow-up, given few available alternative drugs. C1 [Lon, Chanthap; Manning, Jessica E.; Vanachayangkul, Pattaraporn; Se, Youry; Gosi, Panita; Lanteri, Charlotte; Chaorattanakawee, Suwanna; Sriwichai, Sabaithip; Kuntawunginn, Worachet; Buathong, Nillawan; Walsh, Douglas S.; Tyner, Stuart D.; Spring, Michele; Bethell, Delia; Satharath, Prom] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand. [Manning, Jessica E.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Lon, Chanthap; Se, Youry; Chann, Soklyda; Nou, Samon] US Army Med Component, Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [So, Mary; Satharath, Prom] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [Sea, Darapiseth; Chuor, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Juliano, Jonathan J.; Lin, Jessica] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Kaewkungwal, Jaranit] Mahidol Univ, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok 10700, Thailand. [Tang, Douglas] Fast Track Biol, Potomac, MD USA. RP Saunders, D (reprint author), US Army Med Component, Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand. EM David.Saunders@afrims.org FU NIAID NIH HHS [K08 AI110651] NR 34 TC 21 Z9 22 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 25 PY 2014 VL 9 IS 3 AR e93138 DI 10.1371/journal.pone.0093138 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AE0SD UT WOS:000333675600147 PM 24667662 ER PT J AU Zhang, ZQ Zoltewicz, JS Mondello, S Newsom, KJ Yang, ZH Yang, BX Kobeissy, F Guingab, J Glushakova, O Robicsek, S Heaton, S Buki, A Hannay, J Gold, MS Rubenstein, R Lu, XCM Dave, JR Schmid, K Tortella, F Robertson, CS Wang, KKW AF Zhang, Zhiqun Zoltewicz, J. Susie Mondello, Stefania Newsom, Kimberly J. Yang, Zhihui Yang, Boxuan Kobeissy, Firas Guingab, Joy Glushakova, Olena Robicsek, Steven Heaton, Shelley Buki, Andras Hannay, Julia Gold, Mark S. Rubenstein, Richard Lu, Xi-chun May Dave, Jitendra R. Schmid, Kara Tortella, Frank Robertson, Claudia S. Wang, Kevin K. W. TI Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products SO PLOS ONE LA English DT Article ID SPINAL-CORD-INJURY; ALPHA-II-SPECTRIN; CENTRAL-NERVOUS-SYSTEM; GLASGOW OUTCOME SCALE; MULTIPLE-SCLEROSIS; ANTIMYELIN ANTIBODIES; ALZHEIMERS-DISEASE; ANTIPITUITARY ANTIBODIES; CEREBROSPINAL-FLUID; HEAD-INJURY AB The role of systemic autoimmunity in human traumatic brain injury (TBI) and other forms of brain injuries is recognized but not well understood. In this study, a systematic investigation was performed to identify serum autoantibody responses to brain-specific proteins after TBI in humans. TBI autoantibodies showed predominant immunoreactivity against a cluster of bands from 38-50 kDa on human brain immunoblots, which were identified as GFAP and GFAP breakdown products. GFAP autoantibody levels increased by 7 days after injury, and were of the IgG subtype predominantly. Results from in vitro tests and rat TBI experiments also indicated that calpain was responsible for removing the amino and carboxyl termini of GFAP to yield a 38 kDa fragment. Additionally, TBI autoantibody staining co-localized with GFAP in injured rat brain and in primary rat astrocytes. These results suggest that GFAP breakdown products persist within degenerating astrocytes in the brain. Anti-GFAP autoantibody also can enter living astroglia cells in culture and its presence appears to compromise glial cell health. TBI patients showed an average 3.77 fold increase in anti-GFAP autoantibody levels from early (0-1 days) to late (7-10 days) times post injury. Changes in autoantibody levels were negatively correlated with outcome as measured by GOS-E score at 6 months, suggesting that TBI patients with greater anti-GFAP immune-responses had worse outcomes. Due to the long lasting nature of IgG, a test to detect anti-GFAP autoantibodies is likely to prolong the temporal window for assessment of brain damage in human patients. C1 [Zoltewicz, J. Susie; Newsom, Kimberly J.; Yang, Boxuan; Guingab, Joy; Glushakova, Olena] Univ Florida, Dept Psychiat, Ctr Neuroprote & Biomarker Res, Gainesville, FL 32611 USA. [Zhang, Zhiqun; Yang, Zhihui; Kobeissy, Firas; Wang, Kevin K. W.] Banyan Biomarkers Inc, Alachua, FL 32615 USA. [Mondello, Stefania; Gold, Mark S.] Univ Messina, Messina, Italy. [Robicsek, Steven] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Heaton, Shelley] Univ Florida, Gainesville, FL USA. [Buki, Andras] Univ Pecs, Dept Neurosurg, Pecs, Hungary. [Buki, Andras] Hungarian Acad Sci, Clin Neurosci Image Ctr, Pecs, Hungary. [Hannay, Julia] Univ Houston, Dept Psychol, Houston, TX USA. [Rubenstein, Richard] Suny Downstate Med Ctr, Lab Neurodegenerat Dis & CNS Biomarkers, Dept Neurol, Brooklyn, NY 11203 USA. [Rubenstein, Richard] Suny Downstate Med Ctr, Lab Neurodegenerat Dis & CNS Biomarkers, Dept Physiol Pharmacol, Brooklyn, NY 11203 USA. [Lu, Xi-chun May; Dave, Jitendra R.; Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Robertson, Claudia S.] Baylor Coll Med, Dept Neurosurg, Houston, TX 77030 USA. RP Zhang, ZQ (reprint author), Banyan Biomarkers Inc, Alachua, FL 32615 USA. EM zizizhang2012@gmail.com; susiezolt@gmail.com; kwang@ufl.edu RI kobeissy, firas/E-7042-2017; OI kobeissy, firas/0000-0002-5008-6944; Hannay, H. Julia/0000-0001-7023-912X; Wang, Kevin/0000-0002-9343-6473; Mondello, Stefania/0000-0002-8587-3614 FU NIH [R01 NS049175-01, R01-NS052831-01, R01 NS051431-01]; Department of Defense [DAMD17-03-1-0772, DAMD17-03-1-0066] FX This study was supported in part by the NIH (R01 NS049175-01, R01-NS052831-01 and R01 NS051431-01), and in part by the Department of Defense (DAMD17-03-1-0772 and DAMD17-03-1-0066). The funders provide financial support and infrastructure support to this work. NR 67 TC 34 Z9 34 U1 0 U2 18 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 25 PY 2014 VL 9 IS 3 AR e92698 DI 10.1371/journal.pone.0092698 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AE0SD UT WOS:000333675600065 PM 24667434 ER PT J AU Pongsiri, A Ponlawat, A Thaisomboonsuk, B Jarman, RG Scott, TW Lambrechts, L AF Pongsiri, Arissara Ponlawat, Alongkot Thaisomboonsuk, Butsaya Jarman, Richard G. Scott, Thomas W. Lambrechts, Louis TI Differential Susceptibility of Two Field Aedes aegypti Populations to a Low Infectious Dose of Dengue Virus SO PLOS ONE LA English DT Article ID FRENCH-POLYNESIA; DISEASE SEVERITY; VIREMIA; THAILAND; TRANSMISSION; CHILDREN; VILLAGES; STRAINS; BURDEN AB Background: The infectious dose required to infect mosquito vectors when they take a blood meal from a viremic person is a critical parameter underlying the probability of dengue virus (DENV) transmission. Because experimental vector competence studies typically examine the proportion of mosquitoes that become infected at intermediate or high DENV infectious doses in the blood meal, the minimum blood meal titer required to infect mosquitoes is poorly documented. Understanding the factors influencing the lower infectiousness threshold is epidemiologically significant because it determines the transmission potential of humans with a low DENV viremia, possibly including inapparent infections, and during the onset and resolution of the viremic period of acutely infected individuals. Methodology/Principal Findings: We compared the susceptibility of two field-derived Aedes aegypti populations from Kamphaeng Phet, Thailand when they were orally exposed to low titers of six DENV-2 isolates derived from the serum of naturally infected humans living in the same region. The infectious dose, time-point post-blood feeding, viral isolate and mosquito population, were significant predictors of the proportion of mosquitoes that became infected. Importantly, the dose-response profile differed significantly between the two Ae. aegypti populations. Although both mosquito populations had a similar 50% oral infectious dose (OID50), the slope of the dose-response was shallower in one population, resulting in a markedly higher susceptibility at low blood meal titers. Conclusions/Significance: Our results indicate that mosquitoes in nature vary in their infectious dose-response to DENV. Thus, different mosquito populations have a differential ability to acquire DENV infection at low viremia levels. Future studies on human-to-mosquito DENV transmission should not be limited to OID50 values, but rather they should be expanded to account for the shape of the dose-response profile across a range of virus titers. C1 [Pongsiri, Arissara; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Lambrechts, Louis] Inst Pasteur, CNRS, Dept Genomes & Genet, Insect Virus Interact Grp,Unite Rech Associee 301, Paris, France. RP Lambrechts, L (reprint author), Inst Pasteur, CNRS, Dept Genomes & Genet, Insect Virus Interact Grp,Unite Rech Associee 301, Paris, France. EM louis.lambrechts@pasteur.fr RI Lambrechts, Louis/A-2057-2010 OI Lambrechts, Louis/0000-0001-5958-2138 FU United States National Institutes of Health [R01 GM083224]; United States Military Infectious Diseases Research Program; French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]; Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, United States National Institutes of Health FX This study was primarily supported by grant R01 GM083224 from the United States National Institutes of Health and by the United States Military Infectious Diseases Research Program. L. L. received funding from the French Agence Nationale de la Recherche (grant ANR-09-RPDOC-007-01) and from the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID). T. W. S. received support from the Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center, United States National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 8 Z9 8 U1 0 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 24 PY 2014 VL 9 IS 3 AR e92971 DI 10.1371/journal.pone.0092971 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AD7QO UT WOS:000333459900135 PM 24664142 ER PT J AU Beltran, EJ Dingwell, JB Wilken, JM AF Beltran, Eduardo J. Dingwell, Jonathan B. Wilken, Jason M. TI Margins of stability in young adults with traumatic transtibial amputation walking in destabilizing environments SO JOURNAL OF BIOMECHANICS LA English DT Article DE Walking; Transtibial amputation; Perturbations; Lateral stability; Center of mass ID LOWER-LIMB AMPUTATION; DYNAMIC STABILITY; INPATIENT REHABILITATION; LATERAL BALANCE; RISK-FACTORS; GAIT; AMPUTEES; SURFACE; PERTURBATIONS; VARIABILITY AB Understanding how lower-limb amputation affects walking stability, specifically in destabilizing environments, is essential for developing effective interventions to prevent falls. This study quantified mediolateral margins of stability (MOS) and MOS sub-components in young individuals with traumatic unilateral transtibial amputation (TTA) and young able-bodied individuals (AB). Thirteen AB and nine TTA completed five 3-min walking trials in a Computer Assisted Rehabilitation ENvironment (CAREN) system under each of three test conditions: no perturbations, pseudo-random mediolateral translations of the platform, and pseudo-random mediolateral translations of the visual field. Compared to the unperturbed trials, TTA exhibited increased mean MOS and MOS variability during platform and visual field perturbations (p < 0.010). AB exhibited increased mean MOS during visual field perturbations and increased MOS variability during both platform and visual field perturbations (p < 0.050). During platform perturbations, TTA exhibited significantly greater values than AB for mean MOS (p < 0.050) and MOS variability (p < 0.050); variability of the lateral distance between the center of mass (COM) and base of support at initial contact (p < 0.005); mean and variability of the range of COM motion (p < 0.010); and variability of COM peak velocity (p < 0.050). As determined by mean MOS and MOS variability, young and otherwise healthy individuals with transtibial amputation achieved lateral stability similar to that of their able-bodied counterparts during unperturbed and visually-perturbed walking. However, based on mean and variability of MOS, unilateral transtibial amputation was shown to have affected lateral walking stability during platform perturbations. Published by Elsevier Ltd. C1 [Beltran, Eduardo J.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM jason.wilken@us.army.mil OI Dingwell, Jonathan/0000-0001-6990-4153; Wilken, Jason/0000-0002-5556-7667 FU NIH [5R01HD059844] FX Support was provided by NIH grant 5R01HD059844. NR 34 TC 13 Z9 13 U1 2 U2 51 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD MAR 21 PY 2014 VL 47 IS 5 BP 1138 EP 1143 DI 10.1016/j.jbiomech.2013.12.011 PG 6 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AE6GG UT WOS:000334088000029 PM 24444777 ER PT J AU Chung, AW Ghebremichael, M Robinson, H Brown, E Choi, I Lane, S Dugast, AS Schoen, MK Rolland, M Suscovich, TJ Mahan, AE Liao, L Streeck, H Andrews, C Rerks-Ngarm, S Nitayaphan, S de Souza, MS Kaewkungwal, J Pitisuttithum, P Francis, D Michael, NL Kim, JH Bailey-Kellogg, C Ackerman, ME Alter, G AF Chung, Amy W. Ghebremichael, Musie Robinson, Hannah Brown, Eric Choi, Ickwon Lane, Sophie Dugast, Anne-Sophie Schoen, Matthew K. Rolland, Morgane Suscovich, Todd J. Mahan, Alison E. Liao, Larry Streeck, Hendrik Andrews, Charla Rerks-Ngarm, Supachai Nitayaphan, Sorachai de Souza, Mark S. Kaewkungwal, Jaranit Pitisuttithum, Punnee Francis, Donald Michael, Nelson L. Kim, Jerome H. Bailey-Kellogg, Chris Ackerman, Margaret E. Alter, Galit TI Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID NEUTRALIZING ANTIBODY-RESPONSE; HIV-SPECIFIC ANTIBODIES; B-CELL RESPONSES; EFFICACY TRIAL; HIV-1-INFECTED INDIVIDUALS; PLASMODIUM-FALCIPARUM; GLYCOFORM SELECTION; TETANUS VACCINATION; HIGH-THROUGHPUT; INFECTION AB The human phase 2B RV144 ALVAC-HIV vCP1521/AIDSVAX B/E vaccine trial, held in Thailand, resulted in an estimated 31.2% efficacy against HIV infection. By contrast, vaccination with VAX003 (consisting of only AIDSVAX B/E) was not protective. Because protection within RV144 was observed in the absence of neutralizing antibody activity or cytotoxic T cell responses, we speculated that the specificity or qualitative differences in Fc-effector profiles of nonneutralizing antibodies may have accounted for the efficacy differences observed between the two trials. We show that the RV144 regimen elicited nonneutralizing antibodies with highly coordinated Fc-mediated effector responses through the selective induction of highly functional immunoglobulin G3 (IgG3). By contrast, VAX003 elicited monofunctional antibody responses influenced by IgG4 selection, which was promoted by repeated AIDSVAX B/E protein boosts. Moreover, only RV144 induced IgG1 and IgG3 antibodies targeting the crown of the HIV envelope V2 loop, albeit with limited coverage of breakthrough viral sequences. These data suggest that subclass selection differences associated with coordinated humoral functional responses targeting strain-specific protective V2 loop epitopes may underlie differences in vaccine efficacy observed between these two vaccine trials. C1 [Chung, Amy W.; Ghebremichael, Musie; Robinson, Hannah; Lane, Sophie; Dugast, Anne-Sophie; Schoen, Matthew K.; Suscovich, Todd J.; Mahan, Alison E.; Alter, Galit] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Boston, MA 02139 USA. [Brown, Eric; Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Choi, Ickwon; Bailey-Kellogg, Chris] Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA. [Rolland, Morgane; Streeck, Hendrik; Andrews, Charla; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, Silver Spring, MD 20910 USA. [Liao, Larry] Duke Univ, Human Vaccine Inst, Durham, NC 27710 USA. [Liao, Larry] Ctr HIV AIDS Vaccine Immunol, Durham, NC 27710 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Nitayaphan, Sorachai; de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand. [Francis, Donald] Global Solut Infect Dis, Brisbane, CA 94005 USA. RP Alter, G (reprint author), Ragon Inst Massachusetts Gen Hosp Massachusetts I, Boston, MA 02139 USA. EM galter@partners.org RI Dugast, AnneSophie/L-9541-2015 FU US Military HIV Research Program (MHRP); NIH [R01 AI080289]; American Australian Association (Amgen Fellowship); National Health and Medical Research Center [APP1036470]; Bill and Melinda Gates Foundation Collaboration; NIH Harvard Center for AIDS Research [P30 AI060354-02] FX This work was supported by the US Military HIV Research Program (MHRP) (A.W.C. and G.A.), NIH (R01 AI080289) (G.A.), American Australian Association (Amgen Fellowship) (A.W.C.), National Health and Medical Research Center (APP1036470) (A.W.C.), Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (A.W.C., E.B., I.C., A.-S.D., A.E.M., C.B.-K., M.E.A., and G.A.), and NIH Harvard Center for AIDS Research (P30 AI060354-02) (G.A.). NR 41 TC 24 Z9 24 U1 3 U2 6 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD MAR 19 PY 2014 VL 6 IS 228 AR 228ra8 PG 11 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA AD4XV UT WOS:000333256000002 ER PT J AU Yates, NL Liao, HX Fong, YI deCamp, A Vandergrift, NA Williams, WT Alam, SM Ferrari, G Yang, ZY Seaton, KE Berman, PW Alpert, MD Evans, DT O'Connell, RJ Francis, D Sinangil, F Lee, C Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Tartaglia, J Pinter, A Zolla-Pazner, S Gilbert, PB Nabel, GJ Michael, NL Kim, JH Montefiori, DC Haynes, BF Tomaras, GD AF Yates, Nicole L. Liao, Hua-Xin Fong, Youyi deCamp, Allan Vandergrift, Nathan A. Williams, William T. Alam, S. Munir Ferrari, Guido Yang, Zhi-yong Seaton, Kelly E. Berman, Phillip W. Alpert, Michael D. Evans, David T. O'Connell, Robert J. Francis, Donald Sinangil, Faruk Lee, Carter Nitayaphan, Sorachai Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Tartaglia, James Pinter, Abraham Zolla-Pazner, Susan Gilbert, Peter B. Nabel, Gary J. Michael, Nelson L. Kim, Jerome H. Montefiori, David C. Haynes, Barton F. Tomaras, Georgia D. TI Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CONSENSUS ENVELOPE GLYCOPROTEIN; B-CELL RESPONSES; EFFICACY TRIAL; ANTIBODY-RESPONSES; IMMUNOGLOBULIN G3; RV144; GP120; IMMUNOGENICITY; ANTIGENICITY AB HIV-1-specific immunoglobulin G (IgG) subclass antibodies bind to distinct cellular Fc receptors. Antibodies of the same epitope specificity but of a different subclass therefore can have different antibody effector functions. The study of IgG subclass profiles between different vaccine regimens used in clinical trials with divergent efficacy outcomes can provide information on the quality of the vaccine-induced B cell response. We show that HIV-1-specific IgG3 distinguished two HIV-1 vaccine efficacy studies (RV144 and VAX003 clinical trials) and correlated with decreased risk of HIV-1 infection in a blinded follow-up case-control study with the RV144 vaccine. HIV-1-specific IgG3 responses were not long-lived, which was consistent with the waning efficacy of the RV144 vaccine. These data suggest that specific vaccine-induced HIV-1 IgG3 should be tested in future studies of immune correlates in HIV-1 vaccine efficacy trials. C1 [Yates, Nicole L.; Liao, Hua-Xin; Vandergrift, Nathan A.; Williams, William T.; Alam, S. Munir; Ferrari, Guido; Seaton, Kelly E.; Montefiori, David C.; Haynes, Barton F.; Tomaras, Georgia D.] Duke Human Vaccine Inst, Durham, NC 27710 USA. [Yates, Nicole L.; Liao, Hua-Xin; Vandergrift, Nathan A.; Williams, William T.; Alam, S. Munir; Ferrari, Guido; Seaton, Kelly E.; Haynes, Barton F.] Duke Univ, Dept Med, Durham, NC 27710 USA. [Fong, Youyi; deCamp, Allan; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA. [Yang, Zhi-yong; Nabel, Gary J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Berman, Phillip W.] Univ Calif Santa Cruz, Baskin Sch Engn, Santa Cruz, CA 95064 USA. [Alpert, Michael D.; Evans, David T.] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA 02115 USA. [O'Connell, Robert J.] Armed Forces Res Inst Med Sci US Component, Bangkok, Thailand. [Francis, Donald; Sinangil, Faruk; Lee, Carter] Global Solut Infect Dis, San Francisco, CA 94080 USA. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci Royal Thai Army Com, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPH, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Tartaglia, James] Sanofi Pasteur, Swiftwater, PA 18370 USA. [Pinter, Abraham] Rutgers State Univ, New Jersey Med Sch, Newark, NJ 07103 USA. [Zolla-Pazner, Susan] Vet Affairs Med Ctr, New York, NY 10010 USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY 10010 USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Montefiori, David C.; Tomaras, Georgia D.] Duke Univ, Dept Surg, Durham, NC 27710 USA. [Haynes, Barton F.; Tomaras, Georgia D.] Duke Univ, Dept Immunol, Durham, NC 27710 USA. [Tomaras, Georgia D.] Duke Univ, Durham, NC 27710 USA. RP Tomaras, GD (reprint author), Duke Human Vaccine Inst, Durham, NC 27710 USA. EM gdt@duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU Bill and Melinda Gates Foundation grants; Collaboration for AIDS Vaccine Discovery [CAVIMC OPP1032144, 38619, OPP 1033098]; NIH/NIAID/Division of Acquired Immunodeficiency Syndrome: Center for HIV/AIDS Vaccine Immunology Grant [U01 AI067854]; HIV-1 Vaccine Trials Network (HVTN) [5U01 AI46725-05]; Duke University Center for AIDS Research (CFAR) [P30 AI 64518]; intramural program of NIH (Vaccine Research Center, NIAID); Interagency Agreement [Y1-AI-2642-12, Y1-AI-2642-16]; NIAID [W81XWH-11-2-0174, W81XWH-07-2-0067]; U.S. Department of Defense [694251]; U.S. Army Medical Research and Material Command; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. FX This work was supported by the Bill and Melinda Gates Foundation grants, Collaboration for AIDS Vaccine Discovery (CAVIMC OPP1032144, 38619) (N.L.Y., W.T.W., S.M.A., G.F., D.C.M., and G.D.T.), OPP 1033098 (N.L.Y., W.T.W., G.F., B.F.H., and G.D.T.), and NIH/NIAID/Division of Acquired Immunodeficiency Syndrome: Center for HIV/AIDS Vaccine Immunology Grant (U01 AI067854) (N.L.Y., H.-X.L., N.A.V., B.F.H., and G.D.T.). In addition, funding was provided by HIV-1 Vaccine Trials Network (HVTN) (5U01 AI46725-05) (N.L.Y., W.T.W., K.E.S., and G.D.T.) and the Duke University Center for AIDS Research (CFAR) Grant (P30 AI 64518) (G.D.T.). The work was also supported in part by the intramural program of NIH (Vaccine Research Center, NIAID) (G.J.N. and Z.-y.Y.) and an Interagency Agreement (Y1-AI-2642-12 and Y1-AI-2642-16) between the U.S. Army Medical Research and Material Command and the NIAID and by a cooperative agreement (W81XWH-11-2-0174 and W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the U.S. Department of Defense (M.D.A., D.T.E., R.J.O., N.L.M., J.H.K., B.F.H., and G.D.T.) and including contract #694251 (Y.F., A.d.C., and P.B.G.). NR 43 TC 33 Z9 33 U1 0 U2 8 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD MAR 19 PY 2014 VL 6 IS 228 PG 11 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA AD4XV UT WOS:000333256000009 ER PT J AU Asadi, E Zaeem, MA Moitra, A Tschopp, MA AF Asadi, Ebrahim Zaeem, Mohsen Asle Moitra, Amitava Tschopp, Mark A. TI Effect of vacancy defects on generalized stacking fault energy of fcc metals SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article DE generalized stacking fault; vacancy; DFT; EAM; MEAM; molecular dynamics ID INTERATOMIC POTENTIALS APPROPRIATE; HOMOGENEOUS DISLOCATION NUCLEATION; AB-INITIO CALCULATIONS; EMBEDDED-ATOM-METHOD; MOLECULAR-DYNAMICS; SURFACE ENERGIES; CRACK-TIP; CRYSTALLINE; IMPURITIES; SIMULATION AB Molecular dynamics (MD) and density functional theory (DFT) studies were performed to investigate the influence of vacancy defects on generalized stacking fault (GSF) energy of fcc metals. MEAM and EAM potentials were used for MD simulations, and DFT calculations were performed to test the accuracy of different common parameter sets for MEAM and EAM potentials in predicting GSF with different fractions of vacancy defects. Vacancy defects were placed at the stacking fault plane or at nearby atomic layers. The effect of vacancy defects at the stacking fault plane and the plane directly underneath of it was dominant compared to the effect of vacancies at other adjacent planes. The effects of vacancy fraction, the distance between vacancies, and lateral relaxation of atoms on the GSF curves with vacancy defects were investigated. A very similar variation of normalized SFEs with respect to vacancy fractions were observed for Ni and Cu. MEAM potentials qualitatively captured the effect of vacancies on GSF. C1 [Asadi, Ebrahim; Zaeem, Mohsen Asle] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. [Moitra, Amitava] SN Bose Natl Ctr Basic Sci, Kolkata, India. [Tschopp, Mark A.] US Army Res Lab, Engil Corp, Aberdeen Proving Ground, MD 21005 USA. [Tschopp, Mark A.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. RP Asadi, E (reprint author), Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. EM AsadiE@mst.edu; Zaeem@mst.edu RI Asadi, Ebrahim/G-4218-2011; Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 NR 53 TC 8 Z9 8 U1 6 U2 45 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 EI 1361-648X J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD MAR 19 PY 2014 VL 26 IS 11 AR 15404 DI 10.1088/0953-8984/26/11/115404 PG 11 WC Physics, Condensed Matter SC Physics GA AC6NJ UT WOS:000332640200008 PM 24589571 ER PT J AU Kusi, KA Bosomprah, S Dodoo, D Kyei-Baafour, E Dickson, EK Mensah, D Angov, E Dutta, S Sedegah, M Koram, KA AF Kusi, Kwadwo A. Bosomprah, Samuel Dodoo, Daniel Kyei-Baafour, Eric Dickson, Emmanuel K. Mensah, Daniel Angov, Evelina Dutta, Sheetij Sedegah, Martha Koram, Kwadwo A. TI Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation SO MALARIA JOURNAL LA English DT Article DE Malaria; Antibody seroconversion rate; Seroreversion rate; Transmission intensity; Sporozoite antigens; ELISA ID PLASMODIUM-FALCIPARUM TRANSMISSION; SPOROZOITE SURFACE-ANTIGENS; ACQUIRED-IMMUNITY; NORTHERN TANZANIA; EXPOSURE; GHANA; VIVAX; AREA; IDENTIFICATION; PERSISTENCE AB Background: Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is currently the standard tool for transmission monitoring but this is not sensitive enough, especially in areas of very low transmission. Transmission estimation models based on seroconversion rates (lambda) of antibodies to Plasmodium falciparum blood stage antigens are gaining relevance. Estimates of lambda, which is the measure of transmission intensity, correlate with EIR but are limited by long-term persistence of antibodies to blood stage antigens. Seroprevalence of antibodies to sporozoite antigens may be better alternatives since these antigens usually have shorter immune exposure times. The aim of this study was to develop transmission estimation models based on the seroprevalence of antibodies to two P. falciparum sporozoite antigens (CSP, CelTOS) and compare with models based on the classical blood stage antigen AMA1. Methods: Antibody levels in archived plasma from three cross-sectional surveys conducted in 2009 in a low transmission area of Southern Ghana were assessed by indirect ELISA. Seroprevalence of antibodies against CSP, CelTOS and AMA1 were fitted to reversible catalytic models to estimate lambda and corresponding seroreversion rates (rho) for each antibody. Results: Of the three models developed, the anti-CSP model predicted a 13-fold decrease in lambda four years prior to the time of sampling (2009). Anti-AMA1 antibodies formed at a four-fold greater rate compared to that of anti-CelTOS antibodies, and anti-CSP antibodies during the period of decreased lambda. In contrast, anti-AMA1 antibodies decayed at a five-fold slower rate relative to that of anti-CSP antibodies while anti-AMA1 and anti-CelTOS antibody decay rates were not significantly different. Anti-CSP antibodies were relatively short-lived as they formed at an 11.6-fold slower rate relative to their decay during the period of decreased lambda. Conclusions: These features of anti-CSP antibodies can be exploited for the development of models for predicting seasonal, short-term changes in transmission intensity in malaria-endemic areas, especially as the elimination phase of malaria control is approached. C1 [Kusi, Kwadwo A.; Dodoo, Daniel; Kyei-Baafour, Eric; Dickson, Emmanuel K.; Mensah, Daniel; Koram, Kwadwo A.] Univ Ghana, Coll Hlth Sci, Noguchi Mem Inst Med Res, Dept Immunol, Legon, Ghana. [Bosomprah, Samuel] Univ Ghana, Coll Hlth Sci, Sch Publ Hlth, Dept Biostat, Legon, Ghana. [Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Sedegah, Martha] Naval Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Kusi, KA (reprint author), Univ Ghana, Coll Hlth Sci, Noguchi Mem Inst Med Res, Dept Immunol, Legon, Ghana. EM akusi@noguchi.ug.edu.gh OI Kusi, Kwadwo/0000-0001-5483-9985 FU AMANET AIA phase 2 grant [EC1012008]; EDCTP Senior Fellowship Grant [TA.2007.40200.012]; Bill and Melinda Gates Foundation FX We would like to thank Mrs Nana Oye Akuffo, Ms Pamela Nai and Mr Jones Amponsah for providing administrative and technical assistance for this study. The original study that collected the plasma samples used here was cofunded by an AMANET AIA phase 2 grant (number EC1012008) and an EDCTP Senior Fellowship Grant (number TA.2007.40200.012), both of which were awarded to DD.; This study was supported by the Bill and Melinda Gates Foundation-funded Postdoctoral Training Programme at Noguchi Memorial Institute for Medical Research, University of Ghana. Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 8 Z9 8 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 17 PY 2014 VL 13 AR 103 DI 10.1186/1475-2875-13-103 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AF6DH UT WOS:000334804100004 PM 24635830 ER PT J AU Pan, YL Wang, CJ Hill, SC Coleman, M Beresnev, LA Santarpia, JL AF Pan, Yong-Le Wang, Chuji Hill, Steven C. Coleman, Mark Beresnev, Leonid A. Santarpia, Joshua L. TI Trapping of individual airborne absorbing particles using a counterflow nozzle and photophoretic trap for continuous sampling and analysis SO APPLIED PHYSICS LETTERS LA English DT Article ID FORCE OPTICAL TRAP; DIELECTRIC PARTICLES; RADIATION PRESSURE; AIR; MANIPULATION; LEVITATION; AEROSOL AB We describe an integrated opto-aerodynamic system and demonstrate that it enables us to trap absorbing airborne micron-size particles from air, hold them and then release them, and to repeat this sequence many times as would be appropriate for continuous sampling of particles from air. The key parts of the system are a conical photophoretic optical trap and a counter-flow coaxial-double-nozzle that concentrates and then slows particles for trapping. This technology should be useful for on-line applications that require monitoring (by single particle analyses) of a series of successively arriving particles (e.g., from the atmosphere or pharmaceutical or other production facilities) where the total sampling time may last from minutes to days, but where each particle must be held for a short time for measurements (e.g., Raman scattering). (C) 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License. C1 [Pan, Yong-Le; Wang, Chuji; Hill, Steven C.; Coleman, Mark; Beresnev, Leonid A.] US Army Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM 87123 USA. RP Pan, YL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRA136477]; U.S. Army Research Office (ARO) [W911NF-13-1-0429, W911NF-13-1-0297]; U.S. Army Research Laboratory (ARL) FX This research was supported by the Defense Threat Reduction Agency (DTRA, HDTRA136477), U.S. Army Research Office (ARO) Grant Nos. W911NF-13-1-0429 and W911NF-13-1-0297, and U.S. Army Research Laboratory (ARL) mission funds. NR 16 TC 6 Z9 7 U1 2 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 17 PY 2014 VL 104 IS 11 AR 113507 DI 10.1063/1.4869105 PG 4 WC Physics, Applied SC Physics GA AD4WO UT WOS:000333252300078 ER PT J AU Barker, AJ Trainor, TP Douglas, TA Ilgen, AG Majs, F Qiu, CR AF Barker, Amanda J. Trainor, Tom P. Douglas, Thomas A. Ilgen, Anastasia G. Majs, Frantisek Qiu, Canrong TI Lead and antimony speciation associated with weathered bullet fragments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Barker, Amanda J.; Trainor, Tom P.; Majs, Frantisek; Qiu, Canrong] Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK 99775 USA. [Barker, Amanda J.; Douglas, Thomas A.] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Ilgen, Anastasia G.] Sandia Natl Labs, Dept Geochem, Albuquerque, NM 87185 USA. EM ajbarker@alaska.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 96-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600746 ER PT J AU Borodin, O Olguin, M Jow, TR AF Borodin, Oleg Olguin, Marco Jow, T. Richard TI Oxidation stability and decomposition reactions of battery electrolytes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Borodin, Oleg; Olguin, Marco; Jow, T. Richard] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 1 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 10-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457603417 ER PT J AU Fischel, JS Fischel, MH Lafferty, B Sparks, DL AF Fischel, Jason S. Fischel, Matthew H. Lafferty, Brandon Sparks, Dondal L. TI Kinetics of arsenic oxidation by manganese oxide minerals: The influence of origin and structure on reactivity SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Fischel, Jason S.; Fischel, Matthew H.; Sparks, Dondal L.] Univ Delaware, Newark, DE 19716 USA. [Lafferty, Brandon] US Army Corps Engineers, Vicksburg, MS 39180 USA. EM fischelj@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 152-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600795 ER PT J AU Kozlovskaya, V Wang, Y Arcibal, IG Cropek, DM Kharlampieva, E AF Kozlovskaya, Veronika Wang, Yun Arcibal, Imee G. Cropek, Donald M. Kharlampieva, Eugenia TI Highly swellable ultrathin multilayer hydrogels with pH-triggered surface wettability SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Kozlovskaya, Veronika; Wang, Yun; Kharlampieva, Eugenia] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA. [Arcibal, Imee G.; Cropek, Donald M.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. EM vkozlovs@uab.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 424-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457604812 ER PT J AU Olguin, M Borodin, O Jow, R Duin, A Islam, M AF Olguin, Marco Borodin, Oleg Jow, Richard Duin, Adri Islam, Mahbubul TI Molecular dynamics study of oxidation- and reduction-induced solvent decomposition reactions in model battery electrolytes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Olguin, Marco; Borodin, Oleg; Jow, Richard] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Duin, Adri; Islam, Mahbubul] Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. EM marco.a.olguin.ctr@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 384-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600120 ER PT J AU Panaitescu, E Ozturk, B Dubey, M Dhar, NK Sridhar, S Kar, S AF Panaitescu, Eugen Ozturk, Birol Dubey, Madan Dhar, Nibir K. Sridhar, Srinivas Kar, Swastik TI Mixing atoms in a single layer SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Panaitescu, Eugen; Ozturk, Birol; Sridhar, Srinivas; Kar, Swastik] Noertheastern Univ, Dept Phys, Boston, MA USA. [Dubey, Madan; Dhar, Nibir K.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. EM s.kar@neu.edu RI Panaitescu, Eugen/A-9237-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 258-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457600003 ER PT J AU Saykally, R Smith, JW Shih, I Sheardy, A Lam, R Prendergast, D Borodin, O AF Saykally, Richard Smith, J. W. Shih, I. Sheardy, A. Lam, R. Prendergast, D. Borodin, O. TI Solvation structure of LiBF4 in propylene carbonate from X-ray absorption spectroscopy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Saykally, Richard; Smith, J. W.; Shih, I.; Sheardy, A.; Lam, R.] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA. [Saykally, Richard; Smith, J. W.; Shih, I.; Sheardy, A.; Lam, R.; Prendergast, D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Borodin, O.] US Army Res Lab, Adelphi, MD USA. EM saykally@berkeley.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 11-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457603418 ER PT J AU Smith, SQ Zottig, VE Bradshaw, TA Clark, BS Ratka, ZA AF Smith, Stanton Q. Zottig, Victor E. Bradshaw, Thomas A. Clark, Brent S. Ratka, Zachary A. TI Synthesis and biological testing of pyrimidines SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Smith, Stanton Q.; Bradshaw, Thomas A.; Clark, Brent S.; Ratka, Zachary A.] Virginia Mil Inst, Dept Chem, Lexington, VA 24450 USA. [Zottig, Victor E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM smithsq@vmi.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 680-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457603367 ER PT J AU von Cresce, A Russell, SM Urban, N Xu, K AF von Cresce, Arthur Russell, Selena M. Urban, Nathaniel Xu, Kang TI Linking Li+-solvation sheath with interphasial chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [von Cresce, Arthur; Russell, Selena M.; Urban, Nathaniel; Xu, Kang] US Army, Res Lab, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 245-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HZ UT WOS:000348457603645 ER PT J AU Adams, BL Finch, AS Hunt, MA Cangelosi, DN Sarkes, DA Hurley, MM Stratis-Cullum, D AF Adams, Bryn L. Finch, Amethist S. Hunt, Mia A. Cangelosi, Daniela N. Sarkes, Deborah A. Hurley, Margaret M. Stratis-Cullum, Dimitra TI Biodiscovery of novel material binding peptides using bacterial display technology SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Adams, Bryn L.; Finch, Amethist S.; Cangelosi, Daniela N.; Stratis-Cullum, Dimitra] US Army Res Lab, RDRL SEE B, Adelphi, MD 20783 USA. [Hurley, Margaret M.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Sarkes, Deborah A.] GoldBelt Raven, Herndon, VA 20171 USA. [Hunt, Mia A.] Gen Tech Serv, Wall, NJ 07719 USA. EM bryn.adams.ctr@mail.mil NR 0 TC 0 Z9 0 U1 4 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 179-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455200746 ER PT J AU Borodin, O Allen, J Olguin, M Bedrov, D Henderson, W AF Borodin, Oleg Allen, Joshua Olguin, Marco Bedrov, Dmitry Henderson, Wesley TI Insight into structure and transport in electrolytes and SEI components from MD simulations and experiments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Borodin, Oleg; Allen, Joshua; Olguin, Marco] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Bedrov, Dmitry] Univ Utah, Salt Lake City, UT USA. [Henderson, Wesley] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 180-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455205180 ER PT J AU Chandra, D Sankalia, N Arcibal, I Banta, S Cropek, D Karande, P AF Chandra, Divya Sankalia, Nitesh Arcibal, Imee Banta, Scott Cropek, Donald Karande, Pankaj TI Design of affinity peptides from natural protein ligands: A case study of the cardiac troponin complex SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Chandra, Divya; Sankalia, Nitesh; Karande, Pankaj] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Banta, Scott] Columbia Univ, New York, NY 10027 USA. [Arcibal, Imee; Cropek, Donald] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 39180 USA. EM karanp@rpi.edu NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 441-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455201110 ER PT J AU Coppock, MB Farrow, B Finch, AS Lai, B Sarkes, D Maciel, J Heath, J Stratis-Cullum, DN AF Coppock, Matthew B. Farrow, Blake Finch, Amethist S. Lai, Bert Sarkes, Deborah Maciel, Jorge Heath, James Stratis-Cullum, Dimitra N. TI Peptide-based protein capture agents with high affinity, selectivity, and stability as antibody replacements SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Coppock, Matthew B.; Finch, Amethist S.; Sarkes, Deborah; Stratis-Cullum, Dimitra N.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Farrow, Blake; Heath, James] CALTECH, Div Chem & Chemm Engn, Pasadena, CA 91125 USA. [Lai, Bert] InDi Mol, Culver City, CA 90230 USA. [Maciel, Jorge] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM matthew.b.coppock.ctr@mail.mil NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 436-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455201105 ER PT J AU Dong, H Williams, KS Steele, J Orlicki, JA Andzelm, JW Snyder, JF Reiner, RS Rudie, AW AF Dong, Hong Williams, Kristen S. Steele, Joshua Orlicki, Joshua A. Andzelm, Jan W. Snyder, James F. Reiner, Richard S. Rudie, Alan W. TI Tuning interfibril interactions in cellulose nanofibril networks by cations SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Dong, Hong; Williams, Kristen S.; Steele, Joshua; Orlicki, Joshua A.; Andzelm, Jan W.; Snyder, James F.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Reiner, Richard S.; Rudie, Alan W.] US Forest Serv, Forest Prod Lab, USDA, Madison, WI 53726 USA. EM hong.dong.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 129-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455201587 ER PT J AU Germane, K Hurley, M Servinsky, M Gerlach, E Sund, C AF Germane, Katherine Hurley, Margaret Servinsky, Matthew Gerlach, Elliot Sund, Christian TI Clostridium acetobutylicum expresses a Yter like unsaturated glucuronyl hydrolase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Germane, Katherine; Servinsky, Matthew; Gerlach, Elliot; Sund, Christian] Army Res Lab, RDRL SEE B, Adelphi, MD 20783 USA. [Hurley, Margaret] Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM katherine.germane.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 237-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455200804 ER PT J AU Langan, DP Silverstein, R O'Connell-Martins, K Cooper, CL Bavari, S AF Langan, David P. Silverstein, Rosie O'Connell-Martins, Karen Cooper, Christopher L. Bavari, Sina TI Generation of THP1 human monocytic cell lines with RIG-I or MDA-5 receptor knockdown for viral immune response modeling SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Langan, David P.; Silverstein, Rosie; O'Connell-Martins, Karen; Cooper, Christopher L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21701 USA. EM dl11@hood.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 226-BIOL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455200537 ER PT J AU Russell, SM von Cresce, A Baker, D Xu, K AF Russell, Selena M. von Cresce, Arthur Baker, David Xu, Kang TI In-situ and quantitative analyses on solid electrolyte interphase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Russell, Selena M.; von Cresce, Arthur; Baker, David; Xu, Kang] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 36-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455205045 ER PT J AU Servinsky, M Germane, K Liu, SC Gerlach, E Sund, C AF Servinsky, Matthew Germane, Katherine Liu, Sanchao Gerlach, Elliot Sund, Christian TI Feedstock control of metabolic output in Clostridium acetobutylicum SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 247th National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 16-20, 2014 CL Dallas, TX SP Amer Chem Soc C1 [Servinsky, Matthew; Germane, Katherine; Liu, Sanchao; Gerlach, Elliot; Sund, Christian] Army Res Lab, RDRL SEE B, Adelphi, MD 20783 USA. EM Matthew.servinsky.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 16 PY 2014 VL 247 MA 79-BIOL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA AZ8HD UT WOS:000348455200406 ER PT J AU Howard, IL Doyle, JD Hemsley, JM Baumgardner, GL Cooley, LA AF Howard, Isaac L. Doyle, Jesse D. Hemsley, James Michael, Jr. Baumgardner, Gaylon L. Cooley, L. Allen, Jr. TI Emergency paving using hot-mixed asphalt incorporating warm mix technology SO INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING LA English DT Article DE asphalt; emergency paving; disaster; rutting; WMA AB This paper presents results of a study on hot-mixed and warm-compacted asphalt incorporating warm mix technologies for use in emergency construction following a natural disaster. Case studies were first reviewed to investigate feasibility of the concept. Next, an overall emergency paving framework was developed, complemented by a two-component laboratory investigation. Component one developed a series of short-term ageing protocols for use in preparation of test specimens; component two evaluated those specimens for compactability and rut resistance. Results indicated that (1) material could be hauled up to 6h and still be effectively used in emergency paving, (2) the two warm mix additives studied improved compactability of hot-mixed and warm-compacted asphalt and (3) rut resistance was acceptable for emergency applications. A discussion on the post natural disaster permanent residual value of the hot-mixed and warm-compacted material is also provided. C1 [Howard, Isaac L.] Mississippi State Univ, Mississippi State, MS 39762 USA. [Doyle, Jesse D.] US Army Engn Res & Dev Ctr, Airfields & Pavements Branch, Geotech & Struct Lab, CEERD GM A, Vicksburg, MS 39180 USA. [Hemsley, James Michael, Jr.; Baumgardner, Gaylon L.] Paragon Tech Serv Inc, Jackson, MS 39215 USA. [Cooley, L. Allen, Jr.] Burns Cooley Dennis Inc, Ridgeland, MS 39157 USA. RP Howard, IL (reprint author), Mississippi State Univ, 501 Hardy Road Mail Stop 9546, Mississippi State, MS 39762 USA. EM ilhoward@cee.msstate.edu FU Department of Homeland Security; Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory FX This research was funded by the Department of Homeland Security and sponsored by the Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory. The authors wish to thank James Williams (MDOT State Materials Engineer) for guiding and reviewing the work and for providing an agency perspective regarding disaster applications. The authors also wish to thank Mr Larry Michael of Asphalt Technology Consulting for his donation of Sasobit (R), MeadWestVaco (MWV) for its donation of Evotherm (TM) 3G and Ergon Asphalt and Emulsions, Inc. for its donation of all asphalt. Jonathan MacIver (Business Manager) and Dr Everett Crews (Director of Research and Development) of MWV also provided the Yushu project information, which was greatly appreciated. APAC Mississippi and Huey Stockstill, Inc. are also owed thanks for their donation of aggregates and assistance in locating appropriate mix designs. Dr John D'Angelo (consultant) is owed thanks for assistance with data analysis. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 25 TC 3 Z9 5 U1 1 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1029-8436 EI 1477-268X J9 INT J PAVEMENT ENG JI Int. J. Pavement Eng. PD MAR 16 PY 2014 VL 15 IS 3 BP 202 EP 214 DI 10.1080/10298436.2012.721549 PG 13 WC Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Construction & Building Technology; Engineering; Materials Science GA 293HS UT WOS:000329962600002 ER PT J AU Xiao, YF Hsiao, TH Suresh, U Chen, HIH Wu, XW Wolf, SE Chen, YD AF Xiao, Yufei Hsiao, Tzu-Hung Suresh, Uthra Chen, Hung-I Harry Wu, Xiaowu Wolf, Steven E. Chen, Yidong TI A novel significance score for gene selection and ranking SO BIOINFORMATICS LA English DT Article ID FOLD-CHANGE; EXPRESSION DATA; SET ENRICHMENT; CANCER; DISCOVERY AB Motivation: When identifying differentially expressed (DE) genes from high-throughput gene expression measurements, we would like to take both statistical significance (such as P-value) and biological relevance (such as fold change) into consideration. In gene set enrichment analysis (GSEA), a score that can combine fold change and P-value together is needed for better gene ranking. Results: We defined a gene significance score pi-value by combining expression fold change and statistical significance (P-value), and explored its statistical properties. When compared to various existing methods, pi-value based approach is more robust in selecting DE genes, with the largest area under curve in its receiver operating characteristic curve. We applied pi-value to GSEA and found it comparable to P-value and t-statistic based methods, with added protection against false discovery in certain situations. Finally, in a gene functional study of breast cancer profiles, we showed that using pi-value helps elucidating otherwise overlooked important biological functions. C1 [Xiao, Yufei; Chen, Yidong] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Xiao, Yufei; Hsiao, Tzu-Hung; Suresh, Uthra; Chen, Hung-I Harry; Chen, Yidong] Univ Texas Hlth Sci Ctr San Antonio, Computat Biol & Bioinformat Div, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA. [Wu, Xiaowu; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Wu, Xiaowu; Wolf, Steven E.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chen, Yidong] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA. RP Xiao, YF (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. EM xy@ieee.org; cheny8@uthscsa.edu FU Combat Casualty Care Division, United States Army Medical Research and Materiel Command; Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund; National Institutes of Health [R01 GM063120-04]; S.E.W. National Institutes of Health/NCI cancer center [P30 CA054174-17]; Biostatistics and Informatics Shared Resources (BMISR); NIH/NCRR CTSA grant [1UL1RR025767] FX Funding: Combat Casualty Care Division, United States Army Medical Research and Materiel Command; Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund; National Institutes of Health (R01 GM063120-04) to X.W. and S.E.W. National Institutes of Health/NCI cancer center grant (P30 CA054174-17); Biostatistics and Informatics Shared Resources (BMISR); NIH/NCRR CTSA grant (1UL1RR025767) to Y.C. NR 23 TC 19 Z9 19 U1 0 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 EI 1460-2059 J9 BIOINFORMATICS JI Bioinformatics PD MAR 15 PY 2014 VL 30 IS 6 BP 801 EP 807 DI 10.1093/bioinformatics/btr671 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA AD4VR UT WOS:000333249900009 PM 22321699 ER PT J AU Matyas, GR Rice, KC Cheng, K Li, F Antoline, JFG Iyer, MR Jacobson, AE Mayorov, AV Beck, Z Torres, OB Alving, CR AF Matyas, Gary R. Rice, Kenner C. Cheng, Kejun Li, Fuying Antoline, Joshua F. G. Iyer, Malliga R. Jacobson, Arthur E. Mayorov, Alexander V. Beck, Zoltan Torres, Oscar B. Alving, Carl R. TI Facial recognition of heroin vaccine opiates: Type 1 cross-reactivities of antibodies induced by hydrolytically stable haptenic surrogates of heroin, 6-acetylmorphine, and morphine SO VACCINE LA English DT Article DE Haptens; Heroin; 6-Acetylmorphine; Morphine; Type 1 and type 2 cross-reactivity; Liposomes; Monophosphoryl lipid A; Tetanus toxoid; Vaccines to drugs of abuse ID CONJUGATE VACCINE; ADJUVANT SYSTEM; RELAPSE; BEHAVIORS; LIPOSOMES; ABUSE; RATS AB Novel synthetic compounds similar to heroin and its major active metabolites, 6-acetylmorphine and morphine, were examined as potential surrogate haptens for the ability to interface with the immune system for a heroin vaccine. Recent studies have suggested that heroin-like haptens must degrade hydrolytically to induce independent immune responses both to heroin and to the metabolites, resulting in antisera containing mixtures of antibodies (type 2 cross-reactivity). To test this concept, two unique hydrolytically stable haptens were created based on presumed structural facial similarities to heroin or to its active metabolites. After conjugation of a heroin-like hapten (DiAmHap) to tetanus toxoid and mixing with liposomes containing monophosphotyl lipid A, high titers of antibodies after two injections in mice had complementary binding sites that exhibited strong type 1 ("true") specific cross-reactivity with heroin and with both of its physiologically active metabolites. Mice immunized with each surrogate hapten exhibited reduced antinociceptive effects caused by injection of heroin. This approach obviates the need to create hydrolytically unstable synthetic heroin-like compounds to induce independent immune responses to heroin and its active metabolites for vaccine development. Facial recognition of hydrolytically stable surrogate haptens by antibodies together with type 1 cross-reactivities with heroin and its metabolites can help to guide synthetic chemical strategies for efficient development of a heroin vaccine. (C) 2014 Published by Elsevier Ltd. C1 [Matyas, Gary R.; Mayorov, Alexander V.; Beck, Zoltan; Torres, Oscar B.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. [Rice, Kenner C.; Cheng, Kejun; Li, Fuying; Antoline, Joshua F. G.; Jacobson, Arthur E.] Natl Inst Drug Abuse, Drug Design & Synth Sect, Chem Biol Res Branch, Bethesda, MD 20892 USA. [Rice, Kenner C.; Cheng, Kejun; Li, Fuying; Antoline, Joshua F. G.; Jacobson, Arthur E.] NIAAA, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Rice, Kenner C.; Cheng, Kejun; Li, Fuying; Antoline, Joshua F. G.; Iyer, Malliga R.; Jacobson, Arthur E.] NIAAA, NIH, Bethesda, MD 20892 USA. [Mayorov, Alexander V.; Beck, Zoltan; Torres, Oscar B.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command (MRMC); National Institute on Drug Abuse (NIH) [1DP1DA034787-01]; NIH Intramural Research Programs of the National Institute on Drug Abuse; National Institute of Alcohol Abuse and Alcoholism; NIH; DHHS FX This work was supported through a Cooperative Agreement Award (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The work was partially supported by an Avant Garde award to GRM from the National Institute on Drug Abuse (NIH grant no. 1DP1DA034787-01). The work of KC, FL, MRI, AEJ, and KCR was supported by the NIH Intramural Research Programs of the National Institute on Drug Abuse and the National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS. The authors thank Dr. Jay A. Berzofsky (NCI, NIH) for useful discussion of type 1 and type 2 cross-reactivity; Ms. Elaine Morrison, Ms. Courtney Tucker and Mr. Marcus Gallon provided outstanding technical assistance. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adhered to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or NIH, or the U.S. Government. NR 18 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 14 PY 2014 VL 32 IS 13 BP 1473 EP 1479 DI 10.1016/j.vaccine.2014.01.028 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AG7SC UT WOS:000335617600009 PM 24486371 ER PT J AU Mammen, MP Lyons, A Innis, BL Sun, W McKinney, D Chung, RCY Eckels, KH Putnak, R Kanesa-thasan, N Scherer, JM Statler, J Asher, LV Thomas, SJ Vaughn, DW AF Mammen, M. P. Lyons, A. Innis, B. L. Sun, W. McKinney, D. Chung, R. C. Y. Eckels, K. H. Putnak, R. Kanesa-thasan, N. Scherer, J. M. Statler, J. Asher, L. V. Thomas, S. J. Vaughn, D. W. TI Evaluation of Dengue Virus strains for human challenge studies SO VACCINE LA English DT Article DE Dengue; Virus; Vaccine; Challenge ID DOG KIDNEY-CELLS; HEMORRHAGIC-FEVER; NEUTRALIZING ANTIBODIES; VOLUNTEER CHALLENGE; PROTECTIVE EFFICACY; FALCIPARUM-MALARIA; ATTENUATED DENGUE; SERIAL PASSAGE; VACCINE; CANDIDATE AB Discordance between the measured levels of dengue virus neutralizing antibody and clinical outcomes in the first-ever efficacy study of a dengue tetravalent vaccine (Lancet, Nov 2012) suggests a need to re-evaluate the process of pre-screening dengue vaccine candidates to better predict clinical benefit prior to large-scale vaccine trials. In the absence of a reliable animal model and established correlates of protection for dengue, a human dengue virus challenge model may provide an approach to down-select vaccine candidates based on their ability to reduce risk of illness following dengue virus challenge. We report here the challenge of flavivirus-naive adults with cell culture-passaged dengue viruses (DENV) in a controlled setting that resulted in uncomplicated dengue fever (DF). This sets the stage for proof-of-concept efficacy studies that allow the evaluation of dengue vaccine candidates in healthy adult volunteers using qualified DENV challenge strains well before they reach field efficacy trials involving children. Fifteen flavivirus-naive adult volunteers received 1 of 7 DENV challenge strains (n = 12) or placebo (n = 3). Of the twelve volunteers who received challenge strains, five (two DENV-1 45AZ5 and three DENV-3 CH53489 cl24/28 recipients) developed DF, prospectively defined as >= 2 typical symptoms, >= 48 h of sustained fever (> 100.4 degrees F) and concurrent viremia. Based on our study and historical data, we conclude that the DENV-1 and DENV-3 strains can be advanced as human challenge strains. Both of the DENV-2 strains and one DENV-4 strain failed to meet the protocol case definition of DF. The other two DENV-4 strains require additional testing as the illness approximated but did not satisfy the case definition of DF. Three volunteers exhibited effusions (1 pleural/ascites, 2 pericardial) and 1 volunteer exhibited features of dengue (rash, lymphadenopathy, neutropenia and thrombocytopenia), though in the absence of fever and symptoms. The occurrence of effusions in milder DENV infections counters the long-held belief that plasma leakage syndromes are restricted to dengue hemorrhagic fever/dengue shock syndromes (DHF/DSS). Hence, the human dengue challenge model may be useful not only for predicting the efficacy of vaccine and therapeutic candidates in small adult cohorts, but also for contributing to our further understanding of the mechanisms behind protection and virulence. Published by Elsevier Ltd. C1 [Mammen, M. P.; Lyons, A.; Innis, B. L.; Sun, W.; McKinney, D.; Putnak, R.; Kanesa-thasan, N.; Scherer, J. M.; Thomas, S. J.; Vaughn, D. W.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Mammen, M. P.; Lyons, A.; Innis, B. L.; Sun, W.; McKinney, D.; Putnak, R.; Kanesa-thasan, N.; Scherer, J. M.; Thomas, S. J.; Vaughn, D. W.] Walter Reed Army Inst Res, Div Regulated Act, Silver Spring, MD 20910 USA. [Mammen, M. P.; Lyons, A.; Innis, B. L.; Sun, W.; McKinney, D.; Putnak, R.; Kanesa-thasan, N.; Scherer, J. M.; Thomas, S. J.; Vaughn, D. W.] Walter Reed Army Inst Res, Div Vet Serv Program, Silver Spring, MD 20910 USA. [Mammen, M. P.; Lyons, A.; Innis, B. L.; Sun, W.; McKinney, D.; Putnak, R.; Kanesa-thasan, N.; Scherer, J. M.; Thomas, S. J.; Vaughn, D. W.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. [Chung, R. C. Y.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Statler, J.] Walter Reed Army Med Ctr, Serv Radiol, Washington, DC 20307 USA. [Eckels, K. H.; Asher, L. V.] WRAIR, Translat Med Branch, Silver Spring, MD 20910 USA. RP Lyons, A (reprint author), DiLorenzo Tricare Hlth Clin, Corridor 8,Room 233,5801 Army Pentagon, Washington, DC 20310 USA. EM mammen.mammen@vical.com; Arthur.g.lyons.mil@health.mil; Bruce.2.Innis@gsk.com; Wellington.Sun@fda.hhs.gov; dmckinney@clinicalrm.com; Raymond.Chung@va.gov; Kenneth.h.eckels.civ@mail.mil; JRPutnak@hotmail.com; Niranjan.kanesa-thasan@novartis.com; John.Scherer@us.army.mil; jstatrad@aol.com; ludmila.asher@us.army.mil; Stephen.thomas1@us.army.mil; D.W.Vaughn@usa.net NR 50 TC 13 Z9 13 U1 3 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 14 PY 2014 VL 32 IS 13 BP 1488 EP 1494 DI 10.1016/j.vaccine.2013.12.040 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AG7SC UT WOS:000335617600011 PM 24468542 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI Multi-scale coarse-graining of non-conservative interactions in molecular liquids SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; MESOSCOPIC SIMULATION; INTERACTION POTENTIALS; BIOMOLECULAR SYSTEMS; COMPUTER-SIMULATION; OPTIMAL PREDICTION; BROWNIAN-MOTION; POLYMER MELT; NITROMETHANE; SURFACTANTS AB A new bottom-up procedure for constructing non-conservative (dissipative and stochastic) interactions for dissipative particle dynamics (DPD) models is described and applied to perform hierarchical coarse-graining of a polar molecular liquid (nitromethane). The distant-dependent radial and shear frictions in functional-free form are derived consistently with a chosen form for conservative interactions by matching two-body force-velocity and three-body velocity-velocity correlations along the microscopic trajectories of the centroids of Voronoi cells (clusters), which represent the dissipative particles within the DPD description. The Voronoi tessellation is achieved by application of the K-means clustering algorithm at regular time intervals. Consistently with a notion of many-body DPD, the conservative interactions are determined through the multi-scale coarse-graining (MS-CG) method, which naturally implements a pairwise decomposition of the microscopic free energy. A hierarchy of MS-CG/DPD models starting with one molecule per Voronoi cell and up to 64 molecules per cell is derived. The radial contribution to the friction appears to be dominant for all models. As the Voronoi cell sizes increase, the dissipative forces rapidly become confined to the first coordination shell. For Voronoi cells of two and more molecules the time dependence of the velocity autocorrelation function becomes monotonic and well reproduced by the respective MS-CG/DPD models. A comparative analysis of force and velocity correlations in the atomistic and CG ensembles indicates Markovian behavior with as low as two molecules per dissipative particle. The models with one and two molecules per Voronoi cell yield transport properties (diffusion and shear viscosity) that are in good agreement with the atomistic data. The coarser models produce slower dynamics that can be appreciably attributed to unaccounted dissipation introduced by regular Voronoi re-partitioning as well as by larger numerical errors in mapping out the dissipative forces. The framework presented herein can be used to develop computational models of real liquids which are capable of bridging the atomistic and mesoscopic scales. C1 [Izvekov, Sergei; Rice, Betsy M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr. John Brennan and Dr. Joshua Moore of the U.S. Army Research Laboratory for helpful comments. This work was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. NR 94 TC 9 Z9 9 U1 4 U2 90 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 14 PY 2014 VL 140 IS 10 AR 104104 DI 10.1063/1.4866142 PG 17 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AE6RC UT WOS:000334120300005 PM 24628149 ER PT J AU Ettisserry, DP Goldsman, N Lelis, A AF Ettisserry, D. P. Goldsman, N. Lelis, A. TI A methodology to identify and quantify mobility-reducing defects in 4H-silicon carbide power metal-oxide-semiconductor field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID 4H-SIC MOSFETS; SIC/SIO2 INTERFACE; PASSIVATION AB In this paper, we present a methodology for the identification and quantification of defects responsible for low channel mobility in 4H-Silicon Carbide (SiC) power metal-oxide-semiconductor field-effect transistors (MOSFETs). To achieve this, we use an algorithm based on 2D-device simulations of a power MOSFET, density functional simulations, and measurement data. Using physical modeling of carrier mobility and interface traps, we reproduce the experimental I-V characteristics of a 4H-SiC doubly implanted MOSFET through drift-diffusion simulation. We extract the position of Fermi level and the occupied trap density as a function of applied bias and temperature. Using these inputs, our algorithm estimates the number of possible trap types, their energy levels, and concentrations at 4H-SiC/SiO2 interface. Subsequently, we use density functional theory (DFT)-based ab initio simulations to identify the atomic make-up of defects causing these trap levels. We study silicon vacancy and carbon di-interstitial defects in the SiC side of the interface. Our algorithm indicates that the D-it spectrum near the conduction band edge (3.25 eV) is composed of three trap types located at 2.8-2.85 eV, 3.05 eV, and 3.1-3.2 eV, and also calculates their densities. Based on DFT simulations, this work attributes the trap levels very close to the conduction band edge to the C di-interstitial defect. (C) 2014 AIP Publishing LLC. C1 [Ettisserry, D. P.; Goldsman, N.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Lelis, A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ettisserry, DP (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM deva@umd.edu OI Ettisserry, Devanarayanan/0000-0002-4214-2141 NR 38 TC 1 Z9 1 U1 0 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 14 PY 2014 VL 115 IS 10 AR 103706 DI 10.1063/1.4868579 PG 8 WC Physics, Applied SC Physics GA AD2RP UT WOS:000333083100035 ER PT J AU Guo, W Bryan, Z Xie, JQ Kirste, R Mita, S Bryan, I Hussey, L Bobea, M Haidet, B Gerhold, M Collazo, R Sitar, Z AF Guo, Wei Bryan, Zachary Xie, Jinqiao Kirste, Ronny Mita, Seiji Bryan, Isaac Hussey, Lindsay Bobea, Milena Haidet, Brian Gerhold, Michael Collazo, Ramon Sitar, Zlatko TI Stimulated emission and optical gain in AlGaN heterostructures grown on bulk AlN substrates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID QUANTUM-WELL LASERS; THIN-FILMS; DIODES; GAN; SAPPHIRE; CRYSTALS; DYNAMICS; SPECTRA; LEDS AB Optical gain spectra for similar to 250 nm stimulated emission were compared in three different AlGaN-based structures grown on single crystalline AlN substrates: a single AlGaN film, a double heterostructure (DH), and a Multiple Quantum Well (MQW) structure; respective threshold pumping power densities of 700, 250, and 150 kW/cm(2) were observed. Above threshold, the emission was transverse-electric polarized and as narrow as 1.8 nm without a cavity. The DH and MQW structures showed gain values of 50-60 cm(-1) when pumped at 1 MW/cm(2). The results demonstrated the excellent optical quality of the AlGaN-based heterostructures grown on AlN substrates and their potential for realizing electrically pumped sub-280 nm laser diodes. (C) 2014 AIP Publishing LLC. C1 [Guo, Wei; Bryan, Zachary; Kirste, Ronny; Bryan, Isaac; Hussey, Lindsay; Bobea, Milena; Haidet, Brian; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Xie, Jinqiao; Mita, Seiji] HexaTech Inc, Morrisville, NC 27560 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Guo, W (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM wguo2@ncsu.edu FU NSF [DMR-1108071]; ARL/DARPA [W911QX-10-C-0027]; ARO [W911NF-04-D-0003, W911NF-14-C-0008] FX This work was partially supported by NSF (DMR-1108071), ARL/DARPA (W911QX-10-C-0027), and ARO (W911NF-04-D-0003 and W911NF-14-C-0008). All AlN wafers used for heteroepitaxial growth were supplied by HexaTech, Inc., Morrisville, NC; www.hexatechinc.com. NR 37 TC 18 Z9 18 U1 4 U2 45 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 14 PY 2014 VL 115 IS 10 AR 103108 DI 10.1063/1.4868678 PG 6 WC Physics, Applied SC Physics GA AD2RP UT WOS:000333083100008 ER PT J AU Hammamieh, R Chakraborty, N Gautam, A Miller, SA Muhie, S Meyerhoff, J Jett, M AF Hammamieh, Rasha Chakraborty, Nabarun Gautam, Aarti Miller, Stacy-Ann Muhie, Seid Meyerhoff, James Jett, Marti TI Transcriptomic Analysis of the Effects of a Fish Oil Enriched Diet on Murine Brains SO PLOS ONE LA English DT Article ID POLYUNSATURATED FATTY-ACIDS; POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; SUPPLEMENTATION LOWERS INFLAMMATION; CENTRAL-NERVOUS-SYSTEM; DEFICIENT MALE RATS; GENE-EXPRESSION; ALZHEIMERS-DISEASE; OMEGA-3-FATTY-ACID SUPPLEMENTATION; BIPOLAR DISORDER AB The health benefits of fish oil enriched with high omega-3 polyunsaturated fatty acids (n-3 PUFA) are widely documented. Fish oil as dietary supplements, however, show moderate clinical efficacy, highlighting an immediate scope of systematic in vitro feedback. Our transcriptomic study was designed to investigate the genomic shift of murine brains fed on fish oil enriched diets. A customized fish oil enriched diet (FD) and standard lab diet (SD) were separately administered to two randomly chosen populations of C57BL/6J mice from their weaning age until late adolescence. Statistical analysis mined 1,142 genes of interest (GOI) differentially altered in the hemibrains collected from the FD- and SD-fed mice at the age of five months. The majority of identified GOI (similar to 40%) encodes proteins located in the plasma membrane, suggesting that fish oil primarily facilitated the membrane-oriented biofunctions. FD potentially augmented the nervous system's development and functions by selectively stimulating the Src-mediated calcium-induced growth cascade and the downstream PI3K-AKT-PKC pathways. FD reduced the amyloidal burden, attenuated oxidative stress, and assisted in somatostatin activation-the signatures of attenuation of Alzheimer's disease, Parkinson's disease, and affective disorder. FD induced elevation of FKBP5 and suppression of BDNF, which are often linked with the improvement of anxiety disorder, depression, and post-traumatic stress disorder. Hence we anticipate efficacy of FD in treating illnesses such as depression that are typically triggered by the hypoactivities of dopaminergic, adrenergic, cholinergic, and GABAergic networks. Contrastingly, FD's efficacy could be compromised in treating illnesses such as bipolar disorder and schizophrenia, which are triggered by hyperactivities of the same set of neuromodulators. A more comprehensive investigation is recommended to elucidate the implications of fish oil on disease pathomechanisms, and the result-driven repositioning of fish oil utilization may revitalize its therapeutic efficacy. C1 [Hammamieh, Rasha; Chakraborty, Nabarun; Gautam, Aarti; Miller, Stacy-Ann; Muhie, Seid; Meyerhoff, James; Jett, Marti] United States Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. RP Hammamieh, R (reprint author), United States Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. EM Rasha.Hammamieh1@us.army.mil FU Military and Operational Medicine Research Area Directorate III FX Funding was provided by the Military and Operational Medicine Research Area Directorate III. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 139 TC 6 Z9 6 U1 3 U2 41 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 14 PY 2014 VL 9 IS 3 AR e90425 DI 10.1371/journal.pone.0090425 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AC9MJ UT WOS:000332858400014 PM 24632812 ER PT J AU Hang, J Forshey, BM Yang, Y Solorzano, VF Kuschner, RA Halsey, ES Jarman, RG Kochel, TJ AF Hang, Jun Forshey, Brett M. Yang, Yu Solorzano, Victor Fiestas Kuschner, Robert A. Halsey, Eric S. Jarman, Richard G. Kochel, Tadeusz J. TI Genomic Characterization of Group C Orthobunyavirus Reference Strains and Recent South American Clinical Isolates SO PLOS ONE LA English DT Article ID ARTHROPOD-BORNE VIRUSES; FAMILY BUNYAVIRIDAE; PHYLOGENETIC-RELATIONSHIPS; MOLECULAR EPIDEMIOLOGY; SCHMALLENBERG VIRUS; SEQUENCE ALIGNMENTS; RNA VIRUSES; S SEGMENT; IDENTIFICATION; PROTEIN AB Group C orthobunyaviruses (family Bunyaviridae, genus Orthobunyavirus), discovered in the 1950s, are vector-borne human pathogens in the Americas. Currently there is a gap in genomic information for group C viruses. In this study, we obtained complete coding region sequences of reference strains of Caraparu (CARV), Oriboca (ORIV), Marituba (MTBV) and Madrid (MADV) viruses, and five clinical isolates from Peru and Bolivia, using an unbiased de novo approach consisting of random reverse transcription, random anchored PCR amplification, and high throughput pyrosequencing. The small, medium, and large segments encode for a 235 amino acid nucleocapsid protein, an approximately 1430 amino acid surface glycoprotein polyprotein precursor, and a 2248 amino acid RNA-dependent RNA polymerase, respectively. Additionally, the S segment encodes for an 83 amino acid non-structural protein, although this protein is truncated or silenced in some isolates. Phylogenetically, three clinical isolates clustered with CARV, one clustered with MTBV, and one isolate appeared to be a reassortant or a genetic drift resulted from the high variability of the medium segment which was also seen in a few other orthobunyaviruses. These data represent the first complete coding region sequences for this serocomplex of pathogenic orthobunyaviruses. The genome-wide phylogeny of reference strains is consistent with the antigenic properties of the viruses reported in the original serological studies conducted in the 1960s. Comparative analysis of conserved protein regions across group C virus strains and the other orthobunyavirus groups revealed that these group C viruses contain characteristic domains of potential structural and functional significance. Our results provide the basis for the developments of diagnostics, further genetic analyses, and future epidemiologic studies of group C viruses. C1 [Hang, Jun; Yang, Yu; Kuschner, Robert A.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Forshey, Brett M.; Jarman, Richard G.] US Naval Med Res Unit, Lima, Peru. [Solorzano, Victor Fiestas] Inst Nacl Salud, Ctr Nacl Salud Publ, Lima, Peru. [Kochel, Tadeusz J.] US Naval Med Res Ctr, Silver Spring, MD USA. RP Hang, J (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. EM jun.hang.ctr@mail.mil OI FIESTAS, VICTOR/0000-0002-5554-3542 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center FX This work was supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 4 Z9 4 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 14 PY 2014 VL 9 IS 3 AR e92114 DI 10.1371/journal.pone.0092114 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AC9MJ UT WOS:000332858400143 PM 24633174 ER PT J AU Baker, DR Manocchi, AK Lamicq, ML Li, M Nguyen, K Sumner, JJ Bruce, BD Lundgren, CA AF Baker, David R. Manocchi, Amy K. Lamicq, Melissa L. Li, Meng Nguyen, Khoa Sumner, James J. Bruce, Barry D. Lundgren, Cynthia A. TI Comparative Photoactivity and Stability of Isolated Cyanobacterial Monomeric and Trimeric Photosystem I SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID ELECTRON-TRANSFER; CHLAMYDOMONAS-REINHARDTII; PHOTOCURRENT; PLASTOCYANIN; ENZYMES; ENERGY; FILMS; CENTERS; COMPLEX; PROTEIN AB Photoactivity of native trimeric, and non-native monomeric Photosystem I (PSI) extracted from Thermosynechococcus elongatus is compared in a photoelectrochemical system. The PSI monomer is isolated by disassembling a purified PSI trimer using a freeze thaw technique in presence of the short-chain surfactant, octylthioglucoside. Photoactive electrodes are constructed with PSI, functioning as both light absorber and charge-separator, embedded within a conductive polymer film. Despite structural differences between PSI trimers and monomers, electrodes cast with equal chlorophyll-a concentration generate similar photoactivities. Photoaction spectra show that all photocurrent derived from electrodes of PSI and conductive polymer originates solely from PSI with no photocurrent caused by redox mediators in the conductive polymer film. Longevity studies show that the two forms of PSI photodegrade at the same rate while exposed to equal intensities of 676 nm light. Direct photo-oxidation measurements indicate that PSI's monomeric form has fewer light harvesting antennae than trimer, and also shows energy sharing between monomeric subunits in the trimer. The structure of PSI is also found to impact cell performance when applying light at incident powers above 1.5 mW/cm(2) due to the reduced optical cross-section in the monomer, causing saturation at lower light intensities than the trimer. C1 [Baker, David R.; Manocchi, Amy K.; Sumner, James J.; Lundgren, Cynthia A.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Lamicq, Melissa L.; Li, Meng; Nguyen, Khoa; Bruce, Barry D.] Univ Tennessee, Biochem & Cellular & Mol Biol Dept, Knoxville, TN 37996 USA. [Li, Meng; Bruce, Barry D.] Univ Tennessee, Bredesen Ctr Interdisciplinary Res & Educ, Energy Sci & Engn Program, Knoxville, TN 37996 USA. [Bruce, Barry D.] Univ Tennessee, Chem & Biomol Engn Dept, Knoxville, TN 37996 USA. RP Lundgren, CA (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM cynthia.a.lundgren2.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command; TN-SCORE, a multidisciplinary research program; NSF-EPSCoR [EPS-1004083]; Gibson Family Foundation; UTK BCMB Department; National Science Foundation IGERT Program [DGE-0801470] FX STEM imaging was graciously performed by Dr. John R. Dunlap at the University of Tennessee. Financial support from the U.S. Department of the Army and U.S. Army Materiel Command are gratefully acknowledged. Research was supported, in part, by a contractual appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities (D.R.B. and A.K.M.). M.L. has been partially supported as a CIRE Fellow from the Bredesen Center, BDB acknowledges support from TN-SCORE, a multidisciplinary research program sponsored by NSF-EPSCoR (EPS-1004083) and support from the Gibson Family Foundation, K.N., M.L., and B.D.B. acknowledge support from the UTK BCMB Department. K.N. was supported as an IGERT Fellow from the National Science Foundation IGERT Program (DGE-0801470). NR 29 TC 7 Z9 7 U1 3 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 13 PY 2014 VL 118 IS 10 BP 2703 EP 2711 DI 10.1021/jp407948p PG 9 WC Chemistry, Physical SC Chemistry GA AD1PN UT WOS:000333006000010 PM 24547776 ER PT J AU Kiris, E Wang, T Yanpallewar, S Dorsey, SG Becker, J Bavari, S Palko, ME Coppola, V Tessarollo, L AF Kiris, Erkan Wang, Ting Yanpallewar, Sudhirkumar Dorsey, Susan G. Becker, Jodi Bavari, Sina Palko, Mary Ellen Coppola, Vincenzo Tessarollo, Lino TI TrkA In Vivo Function Is Negatively Regulated by Ubiquitination SO JOURNAL OF NEUROSCIENCE LA English DT Article ID NERVE GROWTH-FACTOR; FACTOR RECEPTOR TRKA; NEUROPATHIC PAIN; CELL FATE; NEUROTROPHINS; GENE; MICE; INTERNALIZATION; ENDOCYTOSIS; DELETION AB TrkA is a tyrosine kinase receptor required for development and survival of the peripheral nervous system. In the adult, TrkA and its ligand NGF are peripheral pain mediators, particularly in inflammatory pain states. However, how TrkA regulates the function of nociceptive neurons and whether its activity levels may lead to sensory abnormalities is still unclear. Here we report the characterization of a 3 aa (KFG) domain that negatively regulates TrkA level and function in response to NGF. Deletion of this domain in mouse causes a reduction of TrkA ubiquitination leading to an increase in TrkA protein levels and activity. The number of dorsal root ganglia neurons is not affected by the mutation. However, mutant mice have enhanced thermal sensitivity and inflammatory pain. Together, these data suggest that ubiquitination is a mechanism used in nociceptive neurons to regulate TrkA level and function. Our results may enhance our understanding of how ubiquitination affects TrkA activation following noxious thermal stimulation and inflammatory pain. C1 [Kiris, Erkan; Wang, Ting; Yanpallewar, Sudhirkumar; Becker, Jodi; Palko, Mary Ellen; Tessarollo, Lino] NCI, Neural Dev Sect, Mouse Canc Genet Program, Frederick, MD 21702 USA. [Kiris, Erkan; Becker, Jodi] US Army Med Res Inst Infect Dis, Dept Target Discovery & Expt Microbiol, Frederick, MD 21702 USA. [Dorsey, Susan G.] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA. [Dorsey, Susan G.] Univ Maryland, Program Neurosci, Baltimore, MD 21201 USA. [Coppola, Vincenzo] Ohio State Univ, Wexner Med Ctr, Ctr Comprehens Canc, Dept MVIMG, Columbus, OH 43210 USA. RP Coppola, V (reprint author), Ohio State Univ, Wexner Med Ctr, Ctr Comprehens Canc, Dept MVIMG, Columbus, OH 43210 USA. EM Vincenzo.Coppola@osumc.edu; tessarol@mail.nih.gov RI Coppola, Vincenzo/E-2917-2011 OI Coppola, Vincenzo/0000-0001-6163-1779 FU National Cancer Institute, Center for Cancer Research, National Institutes of Health FX This research was supported by the Intramural Research Program of the National Cancer Institute, Center for Cancer Research, National Institutes of Health. We thank Eileen Southon and Susan Reid for technical help in generating the TrkA mutant mouse model, Colleen Barrick for technical help, and Allan Weissman for discussion and suggestions. We are grateful to Robert Stephens for the discussions at the start of the project and Juan Carlos Arevalo for sharing his unpublished results. NR 33 TC 8 Z9 8 U1 0 U2 4 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD MAR 12 PY 2014 VL 34 IS 11 BP 4090 EP 4098 DI 10.1523/JNEUROSCI.4294-13.2014 PG 9 WC Neurosciences SC Neurosciences & Neurology GA AC9UG UT WOS:000332879500029 PM 24623787 ER PT J AU Brando, C Richardson, JH Murphy, J Ockenhouse, CF Kamau, E AF Brando, Clara Richardson, Jason H. Murphy, Jittawadee Ockenhouse, Christian F. Kamau, Edwin TI Phenotypic characterization of Plasmodium berghei responsive CD8+T cells after immunization with live sporozoites under chloroquine cover SO MALARIA JOURNAL LA English DT Article ID CD8(+) T-CELLS; IMMUNE-RESPONSES; MALARIA VACCINE; PROTRACTED PROTECTION; FALCIPARUM; INFECTION; STAGE; MICE; MEMORY; INTERFERON AB Background: An effective malaria vaccine remains elusive. The most effective experimental vaccines confer only limited and short-lived protection despite production of protective antibodies. However, immunization with irradiated sporozoites, or with live sporozoites under chloroquine cover, has resulted in long-term protection apparently due to the generation of protective CD8+ T cells. The nature and function of these protective CD8+ T cells has not been elucidated. In the current study, the phenotype of CD8+ T cells generated after immunization of C57BL/6 mice with live Plasmodium berghei sporozoites under chloroquine cover was investigated. Methods: Female C57BL/6 mice, C57BL/6 mice B2 macroglobulin -/- [KO], or invariant chain-/- [Ic KO] [6-8 weeks old] were immunized with P. berghei sporozoites and treated daily with 800 mu g/mouse of chloroquine for nine days. This procedure of immunization is referred to as "infection/cure". Mice were challenged by inoculating intravenously 1,000 infectious sporozoites. Appearance of parasitaemia was monitored by Giemsa-stained blood smears. Results: By use of MHC I and MHC II deficient animals, results indicate that CD8+ T cells are necessary for full protection and that production of protective antibodies is either CD4+ T helper cells dependent and/or lymphokines produced by CD4 cells contribute to the protection directly or by helping CD8+ T cells. Further, the phenotype of infection/cure P. berghei responsive CD8+ T cells was determined to be KLRG1(high) CD27(low) CD44(high) and CD62L(low). Conclusion: The KLRG1(high) CD27(low) CD44(high) and CD62L(low) phenotype of CD8+ T cells is associated with protection and should be investigated further as a candidate correlate of protection. C1 [Brando, Clara; Ockenhouse, Christian F.; Kamau, Edwin] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Brando, Clara; Richardson, Jason H.; Murphy, Jittawadee] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM edwin.kamau@us.army.mil NR 39 TC 2 Z9 2 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 12 PY 2014 VL 13 AR 92 DI 10.1186/1475-2875-13-92 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AC8IT UT WOS:000332777400001 PM 24620841 ER PT J AU Su, J Guo, WG Kecskes, LJ Mathaudhu, SN Wei, Q AF Su, J. Guo, W. G. Kecskes, L. J. Mathaudhu, S. N. Wei, Q. TI A rate dependent constitutive model for ECAE Cu based on instrumented nanoindentation results SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Equal channel angular extrusion; Copper; Constitutive model; Rate effect; Nanoindentation ID CHANNEL ANGULAR EXTRUSION; SEVERE PLASTIC-DEFORMATION; STRAIN-RATE SENSITIVITY; HIGH-PRESSURE TORSION; GRAIN-BOUNDARY MIGRATION; TI-IF STEEL; MECHANICAL-PROPERTIES; FCC METALS; MICROSTRUCTURAL EVOLUTION; ULTRAFINE GRAIN AB We have investigated the plastic deformation behavior, especially the strain rate sensitivity of Cu, subjected to severe plastic deformation via equal channel angular extrusion (ECAE) with a varying number of passes. We have performed nanoindentation strain rate jump experiments to measure the hardness values at different loading rates, and determine the strain rate sensitivity (SRS). In turn, the activation volume (V*) associated with plastic deformation of the ECAE Cu has,been derived and analyzed. Based on the dislocation-mediated processes during ECAE, including dislocation accumulation, dynamic recovery and recrystallization, combined with creep theory, a strain rate dependent constitutive model has been constructed for the ECAE Cu. We have reached good agreement between the model predictions and the experimental results. It was found that the model can provide a plausible understanding of the various aspects of the mechanical behavior of the ECAE Cu. (C) 2014 Elsevier B.V. All rights reserved. C1 [Su, J.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Su, J.; Guo, W. G.] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Shaanxi, Peoples R China. [Kecskes, L. J.; Mathaudhu, S. N.] US Army, Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014; Mathaudhu, Suveen/B-4192-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; FU Chinese Ministry of Education; China Scholarship Council; US Army Research Laboratory [W911QX-08-C-0073] FX The authors acknowledge the support from the US Army Research Laboratory for the preparation and supply of specimens. J. Su would like to thank the Chinese Ministry of Education for the support during her stay at UNC-Charlotte, and for the support from China Scholarship Council. Q Wei is supported by the US Army Research Laboratory under Contract no. W911QX-08-C-0073. NR 79 TC 1 Z9 1 U1 1 U2 27 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAR 12 PY 2014 VL 597 BP 279 EP 287 DI 10.1016/j.msea.2013.12.090 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AC8SJ UT WOS:000332804800037 ER PT J AU van Ryn, M Phelan, SM Arora, NK Haggstrom, DA Jackson, GL Zafar, SY Griffin, JM Zullig, LL Provenzale, D Yeazel, MW Jindal, RM Clauser, SB AF van Ryn, Michelle Phelan, Sean M. Arora, Neeraj K. Haggstrom, David A. Jackson, George L. Zafar, S. Yousuf Griffin, Joan M. Zullig, Leah L. Provenzale, Dawn Yeazel, Mark W. Jindal, Rahul M. Clauser, Steven B. TI Patient-Reported Quality of Supportive Care Among Patients With Colorectal Cancer in the Veterans Affairs Health Care System SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CELL LUNG-CANCER; OF-LIFE; DISTRESS MANAGEMENT; PROSTATE-CANCER; NCCN GUIDELINES; RECALL BIAS; DISPARITIES; ONCOLOGY; COMMUNICATION; COORDINATION AB Purpose High-quality supportive care is an essential component of comprehensive cancer care. We implemented a patient-centered quality of cancer care survey to examine and identify predictors of quality of supportive care for bowel problems, pain, fatigue, depression, and other symptoms among 1,109 patients with colorectal cancer. Patients and Methods Patients with new diagnosis of colorectal cancer at any Veterans Health Administration medical center nationwide in 2008 were ascertained through the Veterans Affairs Central Cancer Registry and sent questionnaires assessing a variety of aspects of patient-centered cancer care. We received questionnaires from 63% of eligible patients (N = 1,109). Descriptive analyses characterizing patient experiences with supportive care and binary logistic regression models were used to examine predictors of receipt of help wanted for each of the five symptom categories. Results There were significant gaps in patient-centered quality of supportive care, beginning with symptom assessment. In multivariable modeling, the impact of clinical factors and patient race on odds of receiving wanted help varied by symptom. Coordination of care quality predicted receipt of wanted help for all symptoms, independent of patient demographic or clinical characteristics. Conclusion This study revealed substantial gaps in patient-centered quality of care, difficult to characterize through quality measurement relying on medical record review alone. It established the feasibility of collecting patient-reported quality measures. Improving quality measurement of supportive care and implementing patient-reported outcomes in quality-measurement systems are high priorities for improving the processes and outcomes of care for patients with cancer. C1 [van Ryn, Michelle; Phelan, Sean M.] Mayo Clin, Rochester, MN 55905 USA. [Griffin, Joan M.] Vet Affairs Med Ctr, Durham, NC USA. [Yeazel, Mark W.] Univ Minnesota, Minneapolis, MN USA. [Arora, Neeraj K.; Clauser, Steven B.] NCI, Bethesda, MD 20892 USA. [Haggstrom, David A.] Richard L Roudebush Vet Affairs Med Ctr, Indianapolis, IN 46202 USA. [Haggstrom, David A.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA. [Jackson, George L.; Zullig, Leah L.; Provenzale, Dawn] Durham Vet Affairs Med Ctr, Durham, NC USA. [Jackson, George L.; Zafar, S. Yousuf; Provenzale, Dawn] Duke Univ, Med Ctr, Durham, NC 27706 USA. [Zullig, Leah L.] Univ N Carolina, Chapel Hill, NC USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP van Ryn, M (reprint author), Mayo Clin, Div Hlth Care Policy & Res, 200 First St SW, Rochester, MN 55905 USA. EM vanryn.michelle@mayo.edu FU Interagency Quality of Cancer Care Committee, Applied Research Branch, National Cancer Institute (NCI); Veterans Health Administration; NCI [5R25CA116339] FX Supported by the Interagency Quality of Cancer Care Committee, Applied Research Branch, National Cancer Institute (NCI), through an interagency agreement with the Veterans Health Administration and by NCI Grant No. 5R25CA116339 (L.L.Z.). NR 62 TC 10 Z9 10 U1 1 U2 3 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR 10 PY 2014 VL 32 IS 8 BP 809 EP + DI 10.1200/JCO.2013.49.4302 PG 8 WC Oncology SC Oncology GA AC4IB UT WOS:000332483400018 PM 24493712 ER PT J AU Liyanage, LSI Kim, SG Houze, J Kim, S Tschopp, MA Baskes, MI Horstemeyer, MF AF Liyanage, Laalitha S. I. Kim, Seong-Gon Houze, Jeff Kim, Sungho Tschopp, Mark A. Baskes, M. I. Horstemeyer, M. F. TI Structural, elastic, and thermal properties of cementite (Fe3C) calculated using a modified embedded atom method SO PHYSICAL REVIEW B LA English DT Article ID DENSITY-FUNCTIONAL THEORY; MOLECULAR-DYNAMICS; 1ST PRINCIPLES; ATOMISTIC SIMULATIONS; HIGH-PRESSURE; C SYSTEM; METALS; TEMPERATURE; TRANSITION; COMPRESSION AB Structural, elastic, and thermal properties of cementite (Fe3C) were studied using a modified embedded atom method (MEAM) potential for iron-carbon (Fe-C) alloys. Previously developed Fe and C single-element potentials were used to develop a Fe-C alloy MEAM potential, using a statistics-based optimization scheme to reproduce structural and elastic properties of cementite, the interstitial energies of C in bcc Fe, and heat of formation of Fe-C alloys in L-12 and B-1 structures. The stability of cementite was investigated by molecular dynamics simulations at high temperatures. The nine single-crystal elastic constants for cementite were obtained by computing total energies for strained cells. Polycrystalline elastic moduli for cementite were calculated from the single-crystal elastic constants of cementite. The formation energies of (001), (010), and (100) surfaces of cementite were also calculated. The melting temperature and the variation of specific heat and volume with respect to temperature were investigated by performing a two-phase (solid/liquid) molecular dynamics simulation of cementite. The predictions of the potential are in good agreement with first-principles calculations and experiments. C1 [Liyanage, Laalitha S. I.; Kim, Seong-Gon] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Liyanage, Laalitha S. I.; Houze, Jeff; Kim, Sungho; Horstemeyer, M. F.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Kim, Seong-Gon] Mississippi State Univ, Ctr Computat Sci, Mississippi State, MS 39762 USA. [Tschopp, Mark A.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Baskes, M. I.] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA. [Baskes, M. I.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. RP Kim, SG (reprint author), Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. EM kimsg@ccs.msstate.edu RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 FU Department of Energy [DE-EE0002323, DE-FC26-06NT2755] FX We are grateful to A. B. Belonoshko for his suggestions in conducting the two-phase melting simulations. This work was supported in part by the Department of Energy, GrantsNo. DE-EE0002323 and No. DE-FC26-06NT2755. Computer time allocation was provided by the High Performance Computing Collaboratory (HPC2) at Mississippi State University. NR 54 TC 19 Z9 19 U1 4 U2 69 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD MAR 10 PY 2014 VL 89 IS 9 AR 94102 DI 10.1103/PhysRevB.89.094102 PG 11 WC Physics, Condensed Matter SC Physics GA AC4PY UT WOS:000332504400001 ER PT J AU Tay, RY Wang, XL Tsang, SH Loh, GC Singh, RS Li, H Mallick, G Teo, EHT AF Tay, Roland Yingjie Wang, Xingli Tsang, Siu Hon Loh, Guan Chee Singh, Ram Sevak Li, Hong Mallick, Govind Teo, Edwin Hang Tong TI A systematic study of the atmospheric pressure growth of large-area hexagonal crystalline boron nitride film SO JOURNAL OF MATERIALS CHEMISTRY C LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; ATOMIC LAYER DEPOSITION; THERMAL-DECOMPOSITION; GRAPHENE ELECTRONICS; NANOSHEETS; MONOLAYER; COATINGS; HYDROGEN; FOIL AB The growth of hexagonal boron nitride (h-BN) is of much interest owing to its outstanding properties and for scalable two dimensional (2D) electronics applications. Here, we report the controllable growth of h-BN on a copper substrate using the atmospheric pressure chemical vapor deposition (APCVD) method using ammonia borane as the precursor. The advantages of using APCVD include its ease of setup utilizing fewer resources, low cost and fast growth, all of which are essential for full film coverage and the mass production of 2D h-BN. In this study, we observed a substrate-position dependent evolution of h-BN domains at various stages of growth as the density and size of the domains increased downstream along the quartz tube. Other critical parameters such as growth temperature, deposition time, temperature and mass of precursor were also systemically investigated in order to understand the factors influencing the growth of the h-BN film. Importantly, with a slight increase in the growth temperature of 50 degrees C, we observe a significant (similar to 17-fold) increase in the average domain size, and its further expansion for a longer duration of growth. Likewise, our parametric study highlights the impact of other crucial parameters on domain size, coverage, and thickness of the h-BN film. C1 [Tay, Roland Yingjie; Wang, Xingli; Singh, Ram Sevak; Li, Hong; Teo, Edwin Hang Tong] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore. [Tay, Roland Yingjie; Tsang, Siu Hon; Mallick, Govind] Temasek Labs NTU, Singapore 639798, Singapore. [Loh, Guan Chee] Inst High Performance Comp, Singapore 138632, Singapore. [Loh, Guan Chee] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Mallick, Govind] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Teo, Edwin Hang Tong] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. RP Teo, EHT (reprint author), Nanyang Technol Univ, Sch Elect & Elect Engn, 50 Nanyang Ave, Singapore 639798, Singapore. EM HTTEO@ntu.edu.sg RI Teo, Hang Tong Edwin/E-9437-2015; OI Teo, Hang Tong Edwin/0000-0003-0528-1764; Li, Hong/0000-0002-6975-7787 FU MINDEF Singapore; Army Research Laboratory (ARL), USA FX The authors acknowledge the support from MINDEF Singapore and the Army Research Laboratory (ARL), USA. The authors would also like to thank Prof. Pulickel M. Ajayan of Rice University, Dr Shashi P. Karna and Dr Mark Griep of ARL for their valuable input and suggestions. NR 38 TC 28 Z9 31 U1 7 U2 77 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7526 EI 2050-7534 J9 J MATER CHEM C JI J. Mater. Chem. C PD MAR 7 PY 2014 VL 2 IS 9 BP 1650 EP 1657 DI 10.1039/c3tc32011a PG 8 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA AB6RQ UT WOS:000331917600011 ER PT J AU George, J AF George, Jemin TI On adaptive loop transfer recovery using Kalman filter-based disturbance accommodating control SO IET CONTROL THEORY AND APPLICATIONS LA English DT Article ID FEEDBACK-CONTROL; DESIGN; SYSTEMS; ROBUSTNESS; OBSERVERS AB An adaptive loop transfer recovery (LTR) approach for uncertain systems using the Kalman filter-based disturbance accommodating control scheme is presented. This study shows that the full LTR property of disturbance accommodating control is invariant to system uncertainties and external disturbances acting on the system. Also presented here is an adaptive LTR scheme, where the system process noise intensity matrix is updated online to achieve full LTR. Numerical simulations are presented to verify the superiority of the approach compared to the traditional linear quadratic regulator/LTR. C1 US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP George, J (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jemin.george.civ@mail.mil NR 26 TC 2 Z9 2 U1 0 U2 3 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8644 EI 1751-8652 J9 IET CONTROL THEORY A JI IET Contr. Theory Appl. PD MAR 6 PY 2014 VL 8 IS 4 BP 267 EP 276 DI 10.1049/iet-cta.2013.0671 PG 10 WC Automation & Control Systems; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA AG3NA UT WOS:000335325000006 ER PT J AU Scott, AM Gorb, L Burns, EA Yashkin, SN Hill, FC Leszczynski, J AF Scott, Andrea Michalkova Gorb, Leonid Burns, Elizabeth A. Yashkin, Sergey N. Hill, Frances C. Leszczynski, Jerzy TI Toward Accurate and Efficient Predictions of Entropy and Gibbs Free Energy of Adsorption of High Nitrogen Compounds on Carbonaceous Materials SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; SPACE GAUSSIAN PSEUDOPOTENTIALS; DENSITY-FUNCTIONAL THEORY; AB-INITIO PREDICTION; NONCOVALENT INTERACTIONS; ORGANIC POLLUTANTS; INTERMOLECULAR COMPLEXES; CONTAINING HETEROCYCLES; PERTURBATION-THEORY; AQUEOUS-SOLUTIONS AB The adsorption of high nitrogen compounds (HNCs) on the selected adsorption sites of carbonaceous materials from the gas phase has been investigated by ab initio quantum chemical methods at the density functional level applying both periodic and cluster approaches with M06-2X and BLIP functionals including dispersion forces (BLYP-D2). Among the possible structures of the adsorption complexes, the most stable systems possess nitrogen-containing heterocycles in a parallel orientation toward the modeled carbon surface. The adsorption enthalpies, calculated using the rigid rotor-harmonic oscillator approach (RRHO), were in good agreement with available experimental data. This approach was shown to provide sufficiently accurate adsorption enthalpies from the gas phase for the HNC-carbon systems. The vibrational, rotational, and translation contributions to the adsorption entropy were also analyzed by the approach extended beyond the RRHO scheme. The effects of anharmonic vibrations and internal rotations of the adsorbate on the adsorption sites of the modeled carbon surface were estimated. The Gibbs free energies calculated using the RRHO approach were adjusted to take into account the heterogeneity of the carbon surfaces and underestimation of the adsorption enthalpies at the BLYP-D2(PBC) level. The corrected Gibbs free energy values of adsorption are negative for all of the investigated HNC-carbon systems, and they agree well with available experimental data. This suggests an effective adsorption of selected high nitrogen compounds on carbonaceous materials from the gas phase at 298.15 K. Partition coefficients for distribution of high nitrogen compounds on modeled carbon surfaces were also predicted in good agreement with the experimental results. C1 [Scott, Andrea Michalkova; Hill, Frances C.] US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. [Gorb, Leonid; Burns, Elizabeth A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Yashkin, Sergey N.] Samara State Tech Univ, Samara 443100, Russia. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. RP Scott, AM (reprint author), US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. EM andrea.m.scott@usace.army.mil FU High Performance Computing Major Shared Resource Center at the ERDC (Vicksburg, MS); Office of Naval Research [N00034-03-1-0116] FX We would like to thank Mr. Konstantin Tokarev for his help with the creation and usage of the Open Thermo code. This work was facilitated by support from the High Performance Computing Major Shared Resource Center at the ERDC (Vicksburg, MS) and the Office of Naval Research grant No. N00034-03-1-0116. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 67 TC 3 Z9 3 U1 6 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 6 PY 2014 VL 118 IS 9 BP 4774 EP 4783 DI 10.1021/jp4121832 PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AC8AS UT WOS:000332756000023 ER PT J AU Hu, LB Xu, K AF Hu, Liangbing Xu, Kang TI Nonflammable electrolyte enhances battery safety SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Editorial Material C1 [Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Hu, LB (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM binghu@umd.edu; conrad.k.xu.civ@mail.mil RI Hu, Liangbing/N-6660-2013 NR 6 TC 6 Z9 6 U1 5 U2 44 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 4 PY 2014 VL 111 IS 9 BP 3205 EP 3206 DI 10.1073/pnas.1401033111 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AC5KR UT WOS:000332560300016 PM 24550487 ER PT J AU Goodwell, AE Zhu, ZD Dutta, D Greenberg, JA Kumar, P Garcia, MH Rhoads, BL Holmes, RR Parker, G Berretta, DP Jacobson, RB AF Goodwell, Allison E. Zhu, Zhenduo Dutta, Debsunder Greenberg, Jonathan A. Kumar, Praveen Garcia, Marcelo H. Rhoads, Bruce L. Holmes, Robert R. Parker, Gary Berretta, David P. Jacobson, Robert B. TI Assessment of Floodplain Vulnerability during Extreme Mississippi River Flood 2011 SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SENSITIVITY; VALLEY; SEDIMENTATION AB Regional change in the variability and magnitude of flooding could be a major consequence of future global climate change. Extreme floods have the capacity to rapidly transform landscapes and expose landscape vulnerabilities through highly variable spatial patterns of inundation, erosion, and deposition. We use the historic activation of the Birds Point-New Madrid Floodway during the Mississippi and Ohio River Flooding of 2011 as a scientifically unique stress experiment to analyze indicators of floodplain vulnerability. We use pre- and postflood airborne Light Detection and Ranging data sets to locate erosional and depositional hotspots over the 540 km(2) agricultural Floodway. While riparian vegetation between the river and the main levee breach likely prevented widespread deposition, localized scour and deposition occurred near the levee breaches. Eroded gullies nearly 1 km in length were observed at a low ridge of a relict meander scar of the Mississippi River. Our flow modeling and spatial mapping analysis attributes this vulnerability to a combination of erodible soils, flow acceleration associated with legacy fluvial landforms, and a lack of woody vegetation to anchor soil and enhance flow resistance. Results from this study could guide future mitigation and adaptation measures in cases of extreme flooding. C1 [Goodwell, Allison E.; Zhu, Zhenduo; Dutta, Debsunder; Kumar, Praveen; Garcia, Marcelo H.; Parker, Gary] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Greenberg, Jonathan A.; Rhoads, Bruce L.] Univ Illinois, Dept Geog, Champaign, IL 61820 USA. [Holmes, Robert R.] US Geol Survey, Off Surface Water, Memphis Dist, MO 65201 USA. [Berretta, David P.] US Army Corps Engineers, Memphis Dist, MO 65201 USA. [Jacobson, Robert B.] US Geol Survey, CERC, Columbia, MO 65201 USA. RP Kumar, P (reprint author), Univ Illinois, Dept Civil & Environm Engn, 205 North Mathews Ave, Urbana, IL 61801 USA. EM kumar1@illinois.edu RI Kumar, Praveen/D-2036-2010; OI Kumar, Praveen/0000-0002-4787-0308; Goodwell, Allison/0000-0001-9351-557X; Greenberg, Jonathan/0000-0001-8435-9077 FU NSF RAPID Grant [EAR 1140198]; University of Illinois; Ravindar K and Kavita Kinra Fellowship; Chester and Helen Siess Professorship FX We gratefully acknowledge NSF RAPID Grant No. EAR 1140198 and AVIRIS Data Collection supported by NASA. The USGS provided flow and depth data used for model validation. The USACE provided the processed Lidar 2005 and 2011 DEMs through a Memorandum of Understanding with the University of Illinois. The USACE and USGS both provided insights into the levee breach operation and impacts. A.G. was supported by the Carver and SURGE Fellowships at the University of Illinois. D.D. was supported by Ravindar K and Kavita Kinra Fellowship. Z.Z. and M.H.G. acknowledge the support from Chester and Helen Siess Professorship. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 36 TC 8 Z9 8 U1 7 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 4 PY 2014 VL 48 IS 5 BP 2619 EP 2625 DI 10.1021/es404760t PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AC4MA UT WOS:000332494200013 PM 24512322 ER PT J AU Gerdes, LM Ringler, K Autin, B AF Gerdes, Luke M. Ringler, Kristine Autin, Barbara TI Assessing the Abu Sayyaf Group's Strategic and Learning Capacities SO STUDIES IN CONFLICT & TERRORISM LA English DT Article ID GLOBAL JIHADIS; TERRORISM C1 [Gerdes, Luke M.; Ringler, Kristine; Autin, Barbara] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Gerdes, LM (reprint author), US Mil Acad, Official Mail & Distribut Ctr, 646 Swift Rd, West Point, NY 10996 USA. EM Luke.Gerdes@usma.edu NR 97 TC 1 Z9 1 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1057-610X EI 1521-0731 J9 STUD CONFL TERROR JI Stud. Confl. Terror. PD MAR 4 PY 2014 VL 37 IS 3 BP 267 EP 293 PG 27 WC International Relations; Political Science SC International Relations; Government & Law GA AA8HF UT WOS:000331335500004 ER PT J AU Khan, MA Gee, E Choi, J Kumar, M Jung, W Timmes, TC Kim, HC Jeon, BH AF Khan, Moonis Ali Gee, Eundo Choi, Jaeyoung Kumar, Mahendra Jung, Woosik Timmes, Thomas C. Kim, Hyun-Chul Jeon, Byong-Hun TI Adsorption of Cobalt onto Graphite Nanocarbon-Impregnated Alginate Beads: Equilibrium, Kinetics, and Thermodynamics Studies SO CHEMICAL ENGINEERING COMMUNICATIONS LA English DT Article DE Chemisorption; Graphite nanocarbon-impregnated alginate beads; Kinetics; Thermodynamics ID DIVALENT METAL-IONS; CARBON NANOTUBES; AQUEOUS-SOLUTION; ACTIVATED CARBON; HEAVY-METALS; CA-ALGINATE; REMOVAL; SORPTION; BIOSORPTION; CHITOSAN AB A novel adsorbent was developed impregnating graphite nanocarbon (GNC) into alginate beads (AB) for efficient cobalt (Co(II)) removal from an aqueous solution. Physicochemical and spectroscopic properties of graphite nanocarbon-impregnated alginate beads (ABGNC) were characterized and compared with those of AB. Co(II) adsorption on ABGNC was quantitatively evaluated by determining kinetics and thermodynamics parameters. The Co(II) adsorption capacity onto ABGNC was highest at neutral pH condition. Increasing the temperature from 288 to 318K resulted in a 2.5-fold higher Co(II) adsorption onto AB, while thermal dependence of Co(II) adsorption on ABGNC was not found. Kinetic studies showed an applicability of the pseudo-second-order kinetic model for both AB and ABGNC. Monolayer adsorption was the dominant mechanism of Co(II) adsorption on both AB and ABGNC. Thermodynamic studies revealed that Co(II) adsorption was an endothermic and spontaneous process. Positive values of entropy indicate randomness in solid/aqueous phases, and mean free energy (E-a) fits in the range of chemisorption. C1 [Khan, Moonis Ali] King Saud Univ, Coll Sci, Dept Chem, Adv Mat Res Chair, Riyadh 11451, Saudi Arabia. [Gee, Eundo; Jung, Woosik; Kim, Hyun-Chul; Jeon, Byong-Hun] Yonsei Univ, Dept Environm Engn, Wonju 220710, Gangwon Do, South Korea. [Choi, Jaeyoung] Gangneung Inst, Korea Inst Sci & Technol, Kangnung, South Korea. [Kumar, Mahendra] Univ Duisburg Essen, Essen, Germany. [Timmes, Thomas C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Jeon, BH (reprint author), Yonsei Univ, Dept Environm Engn, Wonju 220710, Gangwon Do, South Korea. EM bhjeon@yonsei.ac.kr RI kumar, mahendra/D-3799-2014; OI Jeon, Byong-Hun/0000-0002-5478-765X FU Global Research Laboratory project; Korea Ministry of Education, Science & Technology (MEST); Korea Ministry of Environment [GT-SWS-11-01-006-0] FX This work was supported by the Global Research Laboratory project, the Brain Korea-21 (BK-21) program of the Korea Ministry of Education, Science & Technology (MEST), and the Eco-Innovation project (Global Top project) of the Korea Ministry of Environment (GT-SWS-11-01-006-0). NR 39 TC 10 Z9 10 U1 0 U2 69 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0098-6445 EI 1563-5201 J9 CHEM ENG COMMUN JI Chem. Eng. Commun. PD MAR 4 PY 2014 VL 201 IS 3 BP 403 EP 418 DI 10.1080/00986445.2013.773426 PG 16 WC Engineering, Chemical SC Engineering GA 254SK UT WOS:000327187100008 ER PT J AU Malinovsky, VS Sola, IR Vala, J AF Malinovsky, Vladimir S. Sola, Ignacio R. Vala, Jiri TI Phase-controlled two-qubit quantum gates SO PHYSICAL REVIEW A LA English DT Article ID TRAPPED IONS; ENTANGLEMENT; COMPUTATION AB We consider an implementation of a two-qubit entangling gate between trapped ions controlled by fully overlapping laser pulses. We particularly address the role of a relative phase between the pulses in the gate design. Though, in general, the relative phase determines the exact form of the two-qubit operation, it is shown that it affects only its single qubit part and has no effect on its entangling content. Based on a general canonical decomposition of the evolution operator we demonstrate that the controlled-NOT ( CNOT) gate can be decomposed in terms of a two-qubit entangled gate and single qubit phase gates. Our study shows that any relative phase errors in two-qubit operations related to phase fluctuations of the external fields can be successfully corrected locally by single-qubit operations, which are usually easy to implement. C1 [Malinovsky, Vladimir S.] US Army Res Lab, Adelphi, MD 20783 USA. [Sola, Ignacio R.] Univ Complutense, Dept Quim Fis 1, Madrid 28040, Spain. [Vala, Jiri] Natl Univ Ireland, Dept Math Phys, Maynooth, Kildare, Ireland. RP Malinovsky, VS (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU National Science Foundation [PHY11-25915]; MICINN Project [CTQ2012-36184]; Science Foundation Ireland under Principal Investigator Award [10/IN.1/I3013] FX The authors thank Klaus Molmer for valuable discussions. This research was supported in part by the National Science Foundation under Grant No. PHY11-25915. I. S. R. acknowledges financial support from the MICINN Project CTQ2012-36184. J.V. acknowledges the financial support of Science Foundation Ireland under Principal Investigator Award No. 10/IN.1/I3013. NR 20 TC 2 Z9 2 U1 2 U2 18 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD MAR 3 PY 2014 VL 89 IS 3 AR 032301 DI 10.1103/PhysRevA.89.032301 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA AC2NK UT WOS:000332337900005 ER PT J AU Del Favero, G Sosa, S Poli, M Tubaro, A Sbaizero, O Lorenzon, P AF Del Favero, Giorgia Sosa, Silvio Poli, Mark Tubaro, Aurelia Sbaizero, Orfeo Lorenzon, Paola TI In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: Structural and functional impairment SO TOXICOLOGY LETTERS LA English DT Article DE 42-Hydroxy-palytoxin; Skeletal muscle; Cytotoxicity; Calcium; Cell elasticity ID ATOMIC-FORCE MICROSCOPY; DINOFLAGELLATE OSTREOPSIS-SIAMENSIS; MAMMALIAN SODIUM-PUMP; MECHANICAL-PROPERTIES; OSTREOCIN-D; OVATOXIN-A; STRUCTURE ELUCIDATION; PALYTOXIN TOXICITY; PUTATIVE PALYTOXIN; MASS-SPECTROMETRY AB Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTXlike compounds. So far, 42-OH-PLTX is one of the few congeners available, and the study of its toxicity represents an important step toward a better comprehension of the mechanism of action of this family of compounds. From this perspective, the aim of this work was to investigate the in vivo and in vitro effect of 42-OH-PLTX on skeletal muscle, one of the most sensitive targets for PLTXs. Our results demonstrate that 42-OH-PLTX causes damage at the skeletal muscle level with a cytotoxic potency similar to that of PLTX. 42-OH-PLTX induces cytotoxicity and cell swelling in a Na+-dependent manner similar to the parent compound. However, the limited Ca2+-dependence of the toxic insult induced by 42-OH-PLTX suggests a specific mechanism of action for this analog. Our results also suggest an impaired response to the physiological agonist acetylcholine and altered cell elasticity. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Del Favero, Giorgia; Sbaizero, Orfeo] Univ Trieste, Dept Engn & Architecture, I-34127 Trieste, Italy. [Sosa, Silvio; Tubaro, Aurelia; Lorenzon, Paola] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Poli, Mark] United States Army, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it FU Project of the Italian Ministry of Education University and Research [PRIN2009JS5YX9 002]; Finanziamento Accordo Quadro Mi. S. E. - ICE - CRUI Bando [16-06-2010] FX This work was supported by the following projects: Project of the Italian Ministry of Education University and Research (PRIN2009JS5YX9 002). Project 99 - Finanziamento Accordo Quadro Mi. S. E. - ICE - CRUI Bando 16-06-2010. Project: Sviluppo KIT diagnostico per analisi genetiche - LR 26/2005 art 23 - Regione FVG. NR 64 TC 4 Z9 4 U1 2 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD MAR 3 PY 2014 VL 225 IS 2 BP 285 EP 293 DI 10.1016/j.toxlet.2013.12.020 PG 9 WC Toxicology SC Toxicology GA 302DE UT WOS:000330580900010 PM 24378260 ER PT J AU Miller, REF Gotshall, DW Geibel, JJ Karpov, KA AF Miller, Rebecca E. Flores Gotshall, Daniel W. Geibel, John J. Karpov, Konstantin A. TI Descriptive analyses and extended distribution records of macroinvertebrates based on remotely operated vehicle surveys offshore of the northern Channel Islands SO CALIFORNIA FISH AND GAME LA English DT Article DE California; Channel Islands; Channel Islands National Marine Sanctuary; macroinvertebrates; marine invertebrates; marine protected areas; remotely operated vehicle ID CALIFORNIA; BANK; SOUTHERN; HABITAT; OREGON AB In 2003, marine protected areas (MPAs) were established offshore of the northern Channel Islands, California. The MPAs are surveyed by remotely operated vehicle (ROV) as part of a larger, ongoing effort to evaluate their effectiveness. To determine macroinvertebrate species distribution and richness, we analyzed the ROV video data collected at five paired sites during 2007-2009. Percent occurrence was used to estimate species richness. Macroinvertebrates observed included harvested species and species with structure-forming potential. Fifty-three invertebrate species were identified along with 20 higher taxonomic complex level classifications when identification to species level was not possible. Two of the five site-pairs formed clusters in two different cluster analyses. Site clustering suggested an island effect or clinal change in the biogeographic regions from the Oregonian Province through the Transition Zone to the Californian Province. The ROV surveys yielded new depth records for three invertebrate species. In addition, the cnidarian Stylaster californicus was found offshore of Santa Rosa Island, expanding its documented distribution within the northern Channel Islands. C1 [Miller, Rebecca E. Flores; Gotshall, Daniel W.] Calif Dept Fish & Wildlife, Monterey, CA 93940 USA. [Geibel, John J.] Calif Dept Fish & Wildlife, Menlo Pk, CA 94025 USA. [Karpov, Konstantin A.] Calif Dept Fish & Wildlife, Ft Bragg, CA 95437 USA. [Karpov, Konstantin A.] Karpov Marine Biol Res, Ft Bragg, CA 95437 USA. RP Miller, REF (reprint author), Calif Dept Fish & Wildlife, 20 Lower Ragsdale Dr,Suite 100, Monterey, CA 93940 USA. EM rebecca.floresmiller@wildlife.ca.gov NR 30 TC 0 Z9 0 U1 3 U2 13 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD SPR PY 2014 VL 100 IS 2 BP 319 EP 342 PG 24 WC Fisheries; Zoology SC Fisheries; Zoology GA AZ5EG UT WOS:000348242700011 ER PT J AU Zhivov, A Herron, D Durston, JL Heron, M Lea, G AF Zhivov, Alexander Herron, Dale Durston, J. Lee Heron, Matthew Lea, George TI Airtightness in New and Retrofitted US Army Buildings SO INTERNATIONAL JOURNAL OF VENTILATION LA English DT Article DE airtightness; air barrier testing protocol; energy conservation AB The Engineer Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) recently developed design/construction strategies that improve the energy efficiency, reduce the potential for mould, and improve indoor air quality in newly constructed buildings and buildings undergoing major renovations. ERDC-CERL performed building envelope leakage tests on Army facilities to test their general integrity and the effect of increased airtightness on building energy consumption. Results were used to develop airtightness criteria and performance requirements for new construction and major renovation projects, which have been included in Army design/construction strategies. Since 2009, the U. S. Army Corps of Engineers (USACE) has implemented an airtightness requirement in all new construction and building enclosure renovation projects. Engineering and Construction Bulletin (ECB) 2012-16 set levels of airtightness for building enclosures at the material, assembly, and system level. ECB 2012-16 requires whole building air leakage tests to be conducted at completion of construction to verify the constructed air barrier system's performance. The current Air Leakage Test Protocol for Building Envelopes developed by ERDC-CERL, the Air Barrier Association of America (ABAA), and other industrial partners was published in May 2012. This paper presents the results of airtightness tests before and after the new requirements were established, updated results for air leakage tests of more than 285 newly constructed and renovated large buildings, and a performance analysis of the design and construction process, air barrier materials, building use, and construction types. These data may support future decisions regarding airtightness levels to be adopted for commercial buildings. C1 [Zhivov, Alexander; Herron, Dale] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Durston, J. Lee] BCRA Inc, Tacoma, WA 98402 USA. [Heron, Matthew] Pie Consulting & Engn, Arvada, CO 80403 USA. [Lea, George] US Army Corps Engineers HQ, Washington, DC 20314 USA. RP Zhivov, A (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA. NR 23 TC 0 Z9 0 U1 3 U2 8 PU VEETECH LTD PI CONVENTRY PA 7A BARCLAYS VENTURE CENTRE, UNIV WARWICK SCI PARK, SIR WILLIAM LYONS RD, CONVENTRY, CV4 7EZ, ENGLAND SN 1473-3315 J9 INT J VENT JI Int. J. Vent. PD MAR PY 2014 VL 12 IS 4 BP 317 EP 330 PG 14 WC Construction & Building Technology; Energy & Fuels SC Construction & Building Technology; Energy & Fuels GA AQ3JO UT WOS:000342688900004 ER PT J AU Marathe, AR Ries, AJ McDowell, K AF Marathe, Amar R. Ries, Anthony J. McDowell, Kaleb TI Sliding HDCA: Single-Trial EEG Classification to Overcome and Quantify Temporal Variability SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING LA English DT Article DE Brain-computer interface (BCI); electroencephalography (EEG); hierarchical discriminant component analysis (HDCA) rapid serial visual resentation (RSVP); real-world environment; single-trial; sliding HDCA; temporal variability ID EVENT-RELATED POTENTIALS; COUPLED COMPUTER VISION; MENTAL CHRONOMETRY; P300; LATENCY; TIME; FATIGUE; SIGNALS; FILTERS; STATE AB Patterns of neural data obtained from electroencephalography (EEG) can be classified by machine learning techniques to increase human-system performance. In controlled laboratory settings this classification approach works well; however, transitioning these approaches into more dynamic, unconstrained environments will present several significant challenges. One such challenge is an increase in temporal variability in measured behavioral and neural responses, which often results in suboptimal classification performance. Previously, we reported a novel classification method designed to account for temporal variability in the neural response in order to improve classification performance by using sliding windows in hierarchical discriminant component analysis (HDCA), and demonstrated a decrease in classification error by over 50% when compared to the standard HDCA method (Marathe et al., 2013). Here, we expand upon this approach and show that embedded within this new method is a novel signal transformation that, when applied to EEG signals, significantly improves the signal-to-noise ratio and thereby enables more accurate single-trial analysis. The results presented here have significant implications for both brain-computer interaction technologies and basic science research into neural processes. C1 [Marathe, Amar R.; Ries, Anthony J.; McDowell, Kaleb] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Marathe, AR (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Research Laboratory; Oak Ridge Associated Universities FX Manuscript received August 21, 2013; revised December 30, 2013 and January 23, 2014; accepted January 23, 2014. Date of publication February 12, 2014; date of current version March 05, 2014. This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. NR 45 TC 15 Z9 15 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1534-4320 EI 1558-0210 J9 IEEE T NEUR SYS REH JI IEEE Trans. Neural Syst. Rehabil. Eng. PD MAR PY 2014 VL 22 IS 2 BP 201 EP 211 DI 10.1109/TNSRE.2014.2304884 PG 11 WC Engineering, Biomedical; Rehabilitation SC Engineering; Rehabilitation GA AP4VV UT WOS:000342078300001 PM 24608681 ER PT J AU Smith-Forbes, E Najera, C Hawkins, D AF Smith-Forbes, Enrique Najera, Cecilia Hawkins, Donald TI Combat Operational Stress Control in Iraq and Afghanistan: Army Occupational Therapy SO MILITARY MEDICINE LA English DT Article AB One of the primary roles for U.S. Army Occupational Therapists (OTs) during combat operations is the Behavioral Health (BH) mission. Army OTs have been involved in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) providing BR treatment to service members, serving in Brigade Combat Teams, and Combat Stress Control Units, however, the impact of the OT BR mission has been scarcely documented. Although the theoretical deployment role of OTs in Combat and Operational Stress Control (COSC) operations has been described, the literature provides minimal experiential application of OTs in the COSC role. This article describes the deployed operational roles of three OTs, two deployed during OIF and one in OEF during 2008-2010. Deployed assignments included positions as Officers in Charge of restoration centers, and of prevention centers to include animal-assisted therapy, and disaster response. Occupational therapists play a vital role within the COSC unit as they add the unique perspective of assessing the service member's functional performance in daily living occupations. C1 [Smith-Forbes, Enrique] Ft Sam Houston Clin, Grad Med Educ, Ft Sam Houston, TX 78234 USA. [Najera, Cecilia] US Army Med Recruiting Stn, Elkridge, MD 21075 USA. [Hawkins, Donald] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Smith-Forbes, E (reprint author), Ft Sam Houston Clin, Grad Med Educ, Bldg 1179,Room 1A43,3100 Schofield Rd, Ft Sam Houston, TX 78234 USA. NR 10 TC 1 Z9 1 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2014 VL 179 IS 3 BP 279 EP 284 DI 10.7205/MILMED-D-13-00452 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UJ UT WOS:000340806200012 PM 24594462 ER PT J AU Skipper, LD Forsten, RD Kim, EH Wilk, JD Hoge, CW AF Skipper, Leonard D. Forsten, Robert D. Kim, Eugene H. Wilk, Joshua D. Hoge, Charles W. TI Relationship of Combat Experiences and Alcohol Misuse Among US Special Operations Soldiers SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; MILITARY SERVICE; PSYCHOLOGICAL HARDINESS; AUDIT-C; IRAQ; AFGHANISTAN; CARE; POPULATION; PREVALENCE AB This study examined the association between specific combat experiences and postdeployment hazardous drinking patterns on selected military populations that are considered high risk, such as personnel belonging to U.S. Army Special Operations Forces. Data collection were conducted in a 5-year span in which 1,323 Special Operations Forces Soldiers were surveyed anonymously from 3 to 6 months after returning from deployment to Iraq/Afghanistan regarding their combat experiences and mental health. Combat items were independently analyzed and placed into the following categories: (1) Fighting, (2) Killing, (3) Threat to oneself, (4) Death/Injury of others, and (5) Atrocities. Alcohol misuse was measured using the Alcohol Use Disorders Identification Test-Consumption. Of the Soldiers sampled, 15% (N = 201) screened positive for alcohol misuse 3 to 6 months postdeployment. Combat experiences relating to fighting, threat to oneself, and atrocities were significantly related to alcohol misuse when analyzed individually. However, when factors were analyzed simultaneously, combat experiences in the fighting category were significantly associated with a positive screen for alcohol misuse. In conclusion, Soldiers belonging to certain elite combat units are significantly more likely to screen positive for alcohol misuse if they are exposed to specific types of fighting combat experiences versus any other type of combat exposure. C1 [Skipper, Leonard D.; Wilk, Joshua D.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci & Neurosci Res, Silver Spring, MD 20910 USA. [Forsten, Robert D.] Brian Allgood Army Community Hosp, APO, AP 96205 USA. [Kim, Eugene H.] US Army Special Operat Command, AOMD Surg Directorate, Ft Bragg, NC 28310 USA. RP Skipper, LD (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci & Neurosci Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 39 TC 2 Z9 2 U1 3 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2014 VL 179 IS 3 BP 301 EP 308 DI 10.7205/MILMED-D-13-00400 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UJ UT WOS:000340806200015 PM 24594465 ER PT J AU Kallingal, GJS Walker, MR Musser, JE Ward, DE McMann, LP AF Kallingal, George J. S. Walker, Marc R. Musser, John E. Ward, David E. McMann, Leah P. TI Impact of Race in Using PSA Velocity to Predict for Prostate Cancer SO MILITARY MEDICINE LA English DT Article ID ANTIGEN VELOCITY; RADICAL PROSTATECTOMY; DOUBLING TIME; GLEASON SCORE; MORTALITY; BIOPSY; RISK AB Objective: To assess whether race is a significant factor in the ability of prostate-specific antigen velocity (PSAV) for predicting high-grade prostate cancer (HGPC). Methods: Records of men who underwent prostate biopsy between January 2003 and December 2007 were retrospectively reviewed to collect demographic data, self-reported race, prostate-specific antigen (PSA) data, and pathology results. PSAV was calculated using linear regression. Subjects were stratified by the presence or absence of HGPC. Median PSA and PSAV values were compared within each racial group using receiver operating characteristic analysis and Student t test. Results: Static PSA was significantly higher in Caucasian men with HGPC (4.81 vs. 8.3 ng/mL, p = 0.0000001) while PSAV was also higher in men with HGPC (0.639 vs. 1.15 ng/mL/yr, p = 0.081). Static PSA in Asians did not perform well in predicting HGPC (5.3 vs. 9.42 ng/mL, p = 0.11), but fared much better than PSAV (0.51 vs. 0.93 ng/mL/yr, p = 0.27). PSA in African Americans did not significantly predict HGPC (6.27 vs. 7.7 ng/mL, p = 0.474), but PSAV showed a stronger trend toward significance (0.615 vs. 1.54 ng/mL/yr, p = 0.068). Conclusions: PSAV may complement static PSA in African Americans and help identify early stage aggressive cancers. C1 [Kallingal, George J. S.; Walker, Marc R.; Musser, John E.; Ward, David E.; McMann, Leah P.] Tripler Army Med Ctr, Honolulu, HI 96850 USA. RP Kallingal, GJS (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96850 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2014 VL 179 IS 3 BP 329 EP 332 DI 10.7205/MILMED-D-13-00332 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UJ UT WOS:000340806200020 PM 24594470 ER PT J AU Schaller, EK Woodall, KA Lemus, H Proctor, SP Russell, DW Crum-Cianflone, NF AF Schaller, Emma K. Woodall, Kelly A. Lemus, Hector Proctor, Susan P. Russell, Dale W. Crum-Cianflone, Nancy F. TI A Longitudinal Comparison of Posttraumatic Stress Disorder and Depression Among Military Service Components SO MILITARY PSYCHOLOGY LA English DT Article DE PTSD; depression; active duty; National Guardsmen; Reservists ID NATIONAL-GUARD SOLDIERS; MENTAL-HEALTH PROBLEMS; MILLENNIUM COHORT; ACTIVE-DUTY; RESERVE-COMPONENT; PRIMARY-CARE; US MILITARY; DEPLOYMENT; IRAQ; PREVALENCE AB The purpose of this study was to longitudinally investigate PTSD and depression between Reserve, National Guard, and active duty continuously and dichotomously. The study consisted of Millennium Cohort Study participants and used self-reported symptoms. Repeated measures modeling assessed PTSD and depression continuously and dichotomously over time. A subanalysis among only recently deployed personnel was conducted. Of the 52,653 participants for the PTSD analysis, the adjusted PCL-C means were 34.6 for Reservists, 34.4 for National Guardsmen, and 34.7 for active duty members, respectively. Of the 53,073 participants for depression analysis, the adjusted PHQ-9 means were 6.8, 6.7, and 7.2, respectively. In dichotomous models, Reservists and National Guardsmen did not have a higher risk of PTSD or depression compared with active duty members. Among deployers, Reservists and National Guardsmen had higher odds (odds ratio = 1.16, 95% confidence limit [CL] [1.01, 1.34] and OR = 1.19, 95% CL [1.04, 1.36], respectively) of screening positive for PTSD, but not depression. Although Reserve and National Guard deployers had modestly increased odds of PTSD compared with active duty members, overall there were minimal differences in the risk and symptom scores of PTSD and depression between service components. C1 [Schaller, Emma K.; Lemus, Hector; Crum-Cianflone, Nancy F.] San Diego State Univ, Dept Publ Hlth, San Diego, CA 92182 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Natick, MA USA. [Russell, Dale W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Schaller, EK (reprint author), San Diego State Univ, Dept Publ Hlth, 5500 Campanile Dr, San Diego, CA 92182 USA. EM emmaschaller@gmail.com NR 37 TC 4 Z9 4 U1 1 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD MAR PY 2014 VL 26 IS 2 BP 77 EP 87 DI 10.1037/mil0000034 PG 11 WC Psychology, Multidisciplinary SC Psychology GA AN2RD UT WOS:000340432100002 ER PT J AU Khitrov, MY Laxminarayan, S Thorsley, D Ramakrishnan, S Rajaraman, S Wesensten, NJ Reifman, J AF Khitrov, Maxim Y. Laxminarayan, Srinivas Thorsley, David Ramakrishnan, Sridhar Rajaraman, Srinivasan Wesensten, Nancy J. Reifman, Jaques TI PC-PVT: A platform for psychomotor vigilance task testing, analysis, and prediction SO BEHAVIOR RESEARCH METHODS LA English DT Article DE Psychomotor vigilance task; Reaction time; Data collection; Performance prediction ID INDIVIDUALIZED PERFORMANCE PREDICTION; SLEEP-DEPRIVED INDIVIDUALS; 2-PROCESS MODEL; DOSE-RESPONSE; REACTION-TIME; RESTRICTION; DEPRIVATION; DEVICE AB Using a personal computer (PC) for simple visual reaction time testing is advantageous because of the relatively low hardware cost, user familiarity, and the relative ease of software development for specific neurobehavioral testing protocols. However, general-purpose computers are not designed with the millisecond-level accuracy of operation required for such applications. Software that does not control for the various sources of delay may return reaction time values that are substantially different from the true reaction times. We have developed and characterized a freely available system for PC-based simple visual reaction time testing that is analogous to the widely used psychomotor vigilance task (PVT). In addition, we have integrated individualized prediction algorithms for near-real-time neurobehavioral performance prediction. We characterized the precision and accuracy with which the system as a whole measures reaction times on a wide range of computer hardware configurations, comparing its performance with that of the "gold standard" PVT-192 device. We showed that the system is capable of measuring reaction times with an average delay of less than 10 ms, a margin of error that is comparable to that of the gold standard. The most critical aspect of hardware selection is the type of mouse used for response detection, with gaming mice showing a significant advantage over standard ones. The software is free to download from http://bhsai.org/downloads/pc-pvt/. C1 [Khitrov, Maxim Y.; Laxminarayan, Srinivas; Thorsley, David; Ramakrishnan, Sridhar; Rajaraman, Srinivasan; Reifman, Jaques] US Army Med Res & Mat Command USAMRMC, Attn MCMR TT, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr TATRC, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command USAMRMC, Attn MCMR TT, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr TATRC, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil NR 14 TC 10 Z9 10 U1 2 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1554-351X EI 1554-3528 J9 BEHAV RES METHODS JI Behav. Res. Methods PD MAR PY 2014 VL 46 IS 1 BP 140 EP 147 DI 10.3758/s13428-013-0339-9 PG 8 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA AM9UI UT WOS:000340226100011 PM 23709163 ER PT J AU Zander, NE Beebe, TP AF Zander, Nicole E. Beebe, Thomas P., Jr. TI Immobilized laminin concentration gradients on electrospun fiber scaffolds for controlled neurite outgrowth SO BIOINTERPHASES LA English DT Article ID NERVE GROWTH-FACTOR; CELL-MIGRATION; PROTEIN GRADIENTS; DENSITY GRADIENTS; CONTACT GUIDANCE; FIBRONECTIN; NANOFIBERS; NEURONS; REGENERATION; ATTACHMENT AB Neuronal process growth is guided by extrinsic environmental cues such as extracellular matrix (ECM) proteins. Recent reports have described that the growth cone extension is superior across gradients of the ECM protein laminin compared to growth across uniformly distributed laminin. In this work, the authors have prepared gradients of laminin on aligned electrospun nanofibers for use as substrates for neuronal growth. The substrates therefore presented both topographical and chemical guidance cues. Step gradients were prepared by the controlled robotic immersion of plasma-treated polycaprolactone fibers reacted with N-hydroxysuccinimide into the protein solution. The gradients were analyzed using x-ray photoelectron spectroscopy and confocal laser scanning microscopy. Gradients with a dynamic range of protein concentrations were successfully generated and neurite outgrowth was evaluated using neuronlike pheochromocytoma cell line 12 (PC12) cells. After 10 days of culture, PC12 neurite lengths varied from 32.7+/-14.2 mu m to 76.3+/-9.1 mu m across the protein concentration gradient. Neurite lengths at the highest concentration end of the gradient were significantly longer than neurite lengths observed for cells cultured on samples with uniform protein coverage. Gradients were prepared both in the fiber direction and transverse to the fiber direction. Neurites preferentially aligned with the fiber direction in both cases indicating that fiber alignment has a more dominant role in controlling neurite orientation, compared to the chemical gradient. (C) 2014 American Vacuum Society. C1 [Zander, Nicole E.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Beebe, Thomas P., Jr.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil NR 55 TC 1 Z9 1 U1 3 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1934-8630 EI 1559-4106 J9 BIOINTERPHASES JI Biointerphases PD MAR PY 2014 VL 9 IS 1 AR 011003 DI 10.1116/1.4857295 PG 9 WC Biophysics; Materials Science, Biomaterials SC Biophysics; Materials Science GA AM4IL UT WOS:000339817100003 PM 24739010 ER PT J AU Dumer, AI Oster, H McCabe, D Rabin, LA Spielman, JL Ramig, LO Borod, JC AF Dumer, Aleksey I. Oster, Harriet McCabe, David Rabin, Laura A. Spielman, Jennifer L. Ramig, Lorraine O. Borod, Joan C. TI Effects of the Lee Silverman Voice Treatment (LSVT (R) R LOUD) on Hypomimia in Parkinson's Disease SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY LA English DT Article DE Hypomimia; Facial expression; Emotion; Communication; Dysarthria; Speech ID DEEP BRAIN-STIMULATION; MINI-MENTAL-STATE; FACIAL EXPRESSION; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; FOLLOW-UP; SPEECH; INDIVIDUALS; COMMUNICATION; ARTICULATION AB Given associations between facial movement and voice, the potential of the Lee Silverman Voice Treatment (LSVT) to alleviate decreased facial expressivity, termed hypomimia, in Parkinson's disease (PD) was examined. Fifty-six participants-16 PD participants who underwent LSVT, 12 PD participants who underwent articulation treatment (ARTIC), 17 untreated PD participants, and 11 controls without PD-produced monologues about happy emotional experiences at pre- and post-treatment timepoints ("T1" and "T2," respectively), 1 month apart. The groups of LSVT, ARTIC, and untreated PD participants were matched on demographic and health status variables. The frequency and variability of facial expressions (Frequency and Variability) observable on 1-min monologue videorecordings were measured using the Facial Action Coding System (FACS). At T1, the Frequency and Variability of participants with PD were significantly lower than those of controls. Frequency and Variability increases of LSVT participants from T1 to T2 were significantly greater than those of ARTIC or untreated participants. Whereas the Frequency and Variability of ARTIC participants at T2 were significantly lower than those of controls, LSVT participants did not significantly differ from controls on these variables at T2. The implications of these findings, which suggest that LSVT reduces parkinsonian hypomimia, for PD-related psychosocial problems are considered. C1 [Dumer, Aleksey I.; McCabe, David; Borod, Joan C.] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA. [Dumer, Aleksey I.; McCabe, David; Rabin, Laura A.; Borod, Joan C.] CUNY, Grad Ctr, Dept Psychol, New York, NY USA. [Oster, Harriet] NYU, Sch Continuing & Profess Studies, Paul McGhee Div, New York, NY USA. [Rabin, Laura A.] CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA. [Spielman, Jennifer L.; Ramig, Lorraine O.] Natl Ctr Voice & Speech, Denver, CO USA. [Ramig, Lorraine O.] Univ Colorado, Dept Speech Language & Hearing Sci, Boulder, CO 80309 USA. [Borod, Joan C.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. RP Dumer, AI (reprint author), US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. EM a.dumer@gmail.com FU National Institutes of Health [R01 DC01150]; Parkinson's Disease Foundation; The Graduate Center of CUNY FX This article is based on the first author's doctoral dissertation, submitted to the Graduate Center of the City University of New York. This work was supported by the National Institutes of Health (J.C.B., R01 DC01150 subcontract to Queens College), a Summer Student Fellowship from the Parkinson's Disease Foundation (A. D.), and a Doctoral Student Grant from The Graduate Center of CUNY (A. D.). The authors gratefully acknowledge the help of Arthur Alimov in conducting this study. Lorraine Ramig receives a lecture honorarium from and has intellectual property rights and ownership interest in LSVT Global Inc., a for-profit organization that conducts training courses and sells products related to LSVT. Dr. Ramig's conflict of interest management plan has been approved by the Office of Conflict of Interest and Commitment at the University of Colorado, Boulder. The authors declare that they have no other conflicts of interest. NR 69 TC 4 Z9 4 U1 4 U2 23 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1355-6177 EI 1469-7661 J9 J INT NEUROPSYCH SOC JI J. Int. Neuropsychol. Soc. PD MAR PY 2014 VL 20 IS 3 BP 302 EP 312 DI 10.1017/S1355617714000046 PG 11 WC Clinical Neurology; Neurosciences; Psychiatry; Psychology SC Neurosciences & Neurology; Psychiatry; Psychology GA AM0UG UT WOS:000339561800006 PM 24524211 ER PT J AU Marchesi, MJM AF Marchesi, Major Justin M. TI PASS THE SIGAR: CUTTING THROUGH THE SMOKE OF LESSONS LEARNED IN SIMPLIFIED CONTINGENCY CONTRACTING OPERATIONS SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC 20301 USA. RP Marchesi, MJM (reprint author), US Army, Washington, DC 20301 USA. NR 36 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 53 EP 82 PG 30 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500002 ER PT J AU Fields, MJE AF Fields, Major Jonathan E. TI THE EFFECTS OF CHINA'S RISING LEGAL INFLUENCE IN AFRICA ON AFRICOM'S STRATEGIC OBJECTIVES SO MILITARY LAW REVIEW LA English DT Article C1 [Fields, Major Jonathan E.] US Army, Charlottesville, VA 22901 USA. [Fields, Major Jonathan E.] US Army, Judge Advocate Gen Sch, Adm & Civil Law Dept, Charlottesville, VA 22901 USA. RP Fields, MJE (reprint author), US Army, Judge Advocate Gen Sch, Adm & Civil Law Dept, Charlottesville, VA 22901 USA. NR 47 TC 0 Z9 0 U1 2 U2 7 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 83 EP 105 PG 23 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500003 ER PT J AU Watts, S AF Watts, Sean TI LAW-OF-WAR PERFIDY SO MILITARY LAW REVIEW LA English DT Article ID INTERNATIONAL-LAW; GENEVA CONVENTIONS; HUMANITARIAN LAW; CONFLICT C1 [Watts, Sean] Creighton Univ, Sch Law, Omaha, NE 68178 USA. [Watts, Sean] US Mil Acad, US Army Reserve Reserve Instructor, Dept Law, West Point, NY USA. RP Watts, S (reprint author), Creighton Univ, Sch Law, Omaha, NE 68178 USA. NR 224 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 106 EP 175 PG 70 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500004 ER PT J AU Maclean, FL AF Maclean, French L. TI THE SEVENTH ANNUAL GEORGE S. PRUGH LECTURE IN MILITARY LEGAL HISTORY SO MILITARY LAW REVIEW LA English DT Article C1 US Mil Acad, Sch Adv Mil Studies, Kansas City, KS USA. RP Maclean, FL (reprint author), US Mil Acad, Sch Adv Mil Studies, Kansas City, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 262 EP 274 PG 13 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500008 ER PT J AU Vargo, MSP AF Vargo, Major Steven P. TI THINKING, FAST AND SLOW SO MILITARY LAW REVIEW LA English DT Book Review C1 [Vargo, Major Steven P.] US Army, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA 22901 USA. RP Vargo, MSP (reprint author), US Army, Judge Advocate Gen Legal Ctr & Sch, 62nd Judge Advocate Officer Grad Course, Charlottesville, VA 22901 USA. NR 4 TC 0 Z9 0 U1 2 U2 4 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 275 EP 284 PG 10 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500009 ER PT J AU Burch, DT AF Burch, Dylan T. TI BLIND SPOTS: WHY WE FAIL TO DO WHAT'S RIGHT AND WHAT TO DO ABOUT IT SO MILITARY LAW REVIEW LA English DT Book Review C1 US Army, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA 22901 USA. RP Burch, DT (reprint author), US Army, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA 22901 USA. NR 3 TC 0 Z9 0 U1 1 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2014 VL 219 BP 292 EP 299 PG 8 WC Law SC Government & Law GA AL9IJ UT WOS:000339454500011 ER PT J AU Regueiro, RA Zhang, B Wozniak, SL AF Regueiro, R. A. Zhang, B. Wozniak, S. L. TI Large Deformation Dynamic Three-Dimensional Coupled Finite Element Analysis of Soft Biological Tissues Treated as Biphasic Porous Media SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES LA English DT Article DE soft biological tissues; biphasic mixture theory; dynamics; large deformations; coupled three-dimensional finite element analysis ID CONSTITUTIVE FRAMEWORK; FORMULATIONS; MODELS; MIXTURES; DAMAGE AB The paper presents three-dimensional, large deformation, coupled finite element analysis (PEA) of dynamic loading on soft biological tissues treated as biphasic (solid-fluid) porous media. An overview is presented of the biphasic solid-fluid mixture theory at finite strain, including inertia terms. The solid skeleton is modeled as an isotropic, compressible, hyperelastic material. FEA simulations include: (1) compressive uniaxial strain loading on a column of lung parenchyma with either pore air or water fluid, (2) out-of-plane pressure loading on a thin slab of lung parenchyma with either pore air or water fluid, and (3) pressure loading on a 1/8th symmetry vertebral disc (nucleus and annulus) with pore water. For the simulations, mixed formulation Q27P8 and stabilized Q8P8 finite elements are compared ("Q" indicates the number of solid skeleton displacement nodes, and "P" the number of pore fluid pressure nodes). The PEA results demonstrate the interplay of dynamics (wave propagation through solid skeleton and pore fluid), large deformations, effective stress and pore fluid pressure coupling, compressibility and viscosity of pore fluid, and three-dimensional effects for soft biological tissues treated as biphasic porous media. C1 [Regueiro, R. A.; Zhang, B.] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Wozniak, S. L.] US Army Res Lab, Bowhead Sci & Technol LLC, Aberdeen Proving Ground, MD 21005 USA. RP Regueiro, RA (reprint author), Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. EM richard.regueiro@colorado.edu OI Regueiro, Richard/0000-0002-1669-1753 FU United States Army Medical Research and Materiel Command (USAMRMC) [W81XWH-10-1-1036]; U.S. Army Research Office Scientific Services Program [W911NF-011-D-0001]; U.S. Army Research Laboratory [W911QX-09-C-0057]; UPS Foundation FX The work was funded by grant W81XWH-10-1-1036 from the United States Army Medical Research and Materiel Command (USAMRMC). RAR was also funded through the U.S. Army Research Office Scientific Services Program administered by Battelle Memorial Institute, under contract W911NF-011-D-0001. SLW was funded through contract W911QX-09-C-0057 from the U.S. Army Research Laboratory. RAR acknowledges support from a UPS Foundation visiting professorship in the Department of Civil and Environmental Engineering at Stanford University during the writing of the article. NR 31 TC 0 Z9 0 U1 0 U2 7 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1526-1492 EI 1526-1506 J9 CMES-COMP MODEL ENG JI CMES-Comp. Model. Eng. Sci. PD MAR PY 2014 VL 98 IS 1 BP 1 EP 39 PG 39 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA AL2RV UT WOS:000338973800002 ER PT J AU Hoffman, RR Hawley, JK Bradshaw, JM AF Hoffman, Robert R. Hawley, John K. Bradshaw, Jeffrey M. TI Myths of Automation, Part 2: Some Very Human Consequences SO IEEE INTELLIGENT SYSTEMS LA English DT Editorial Material DE Training; Automation; Personnel; Missiles; Intelligent systems; Cognition; human-centered computing; undisciplined automation; Patriot missile; intelligent systems ID SYSTEMS; WORK C1 [Hoffman, Robert R.; Bradshaw, Jeffrey M.] Inst Human & Machine Cognit, Pensacola, FL USA. [Hawley, John K.] Army Res Lab, Human Res & Engn Directorate, Ft Bliss, TX USA. RP Hoffman, RR (reprint author), Inst Human & Machine Cognit, Pensacola, FL USA. EM rhoffman@ihmc.us; john.k.hawley.civ@mail.mil; jbradshaw@ihmc.us NR 12 TC 2 Z9 2 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1541-1672 EI 1941-1294 J9 IEEE INTELL SYST JI IEEE Intell. Syst. PD MAR-APR PY 2014 VL 29 IS 2 BP 82 EP 85 DI 10.1109/MIS.2014.25 PG 4 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA AK0NL UT WOS:000338110000014 ER PT J AU Chou, L Batchinsky, A Belenkiy, S Jing, J Ramalingam, T Brenner, M Chen, ZP AF Chou, Lidek Batchinsky, Andriy Belenkiy, Slava Jing, Joseph Ramalingam, Tirunelveli Brenner, Matthew Chen, Zhongping TI In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE optical coherence tomography; long-range optical coherence tomography; smoke inhalation injury AB We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Chou, Lidek; Jing, Joseph; Brenner, Matthew; Chen, Zhongping] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA. [Chou, Lidek; Ramalingam, Tirunelveli] OCT Med Imaging Inc, Irvine, CA 92612 USA. [Batchinsky, Andriy; Belenkiy, Slava] US Army Inst Surg Res, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA. [Jing, Joseph; Chen, Zhongping] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA. [Brenner, Matthew] Univ Calif Irvine, Med Ctr, Div Pulm & Crit Care, Orange, CA 92868 USA. RP Chen, ZP (reprint author), Univ Calif Irvine, Beckman Laser Inst, 1002 Hlth Sci Rd East, Irvine, CA 92612 USA. EM z2chen@uci.edu FU Military Medical Photonics Program AFOSR Grant [FA9550-10-1-0538]; DoD Award [W81XWH-09-C-0023] FX We would like to thank Dr. Sari Mahon at UC Irvine for her assistance with IACUC approval, logistics of the study preparation. Mr. Max Wiedmann, Mr. Emon Heidari, Dr. Jun Zhang for their assistance with the system development. Dr. Corina Necsoiu, Dr. Stefan Kreyer, Mr. Pete Walker at the U. S. Army Institute of Surgical Research for their assistance during image acquisition. This work is supported by Military Medical Photonics Program AFOSR Grant # FA9550-10-1-0538 to UCI and DoD Award W81XWH-09-C-0023 to OCT Medical Imaging. NR 13 TC 7 Z9 7 U1 1 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD MAR PY 2014 VL 19 IS 3 AR 036018 DI 10.1117/1.JBO.19.3.036018 PG 6 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AK3OG UT WOS:000338333400031 PM 24664245 ER PT J AU Kasper, RW Cecotti, H Touryan, J Eckstein, MP Giesbrecht, B AF Kasper, Ryan W. Cecotti, Hubert Touryan, Jon Eckstein, Miguel P. Giesbrecht, Barry TI Isolating the Neural Mechanisms of Interference during Continuous Multisensory Dual-task Performance SO JOURNAL OF COGNITIVE NEUROSCIENCE LA English DT Article ID EVENT-RELATED POTENTIALS; ATTENTIONAL BLINK; VISUAL-ATTENTION; HUMAN ELECTROPHYSIOLOGY; EVOKED-POTENTIALS; BRAIN; BOTTLENECK; RESOURCES; RESPONSES; SINGLE AB The need to engage in multiple tasks simultaneously is often encountered in everyday experience, but coordinating between two or more tasks can lead to impaired performance. Typical investigations of multitasking impairments have focused on the performance of two tasks presented in close temporal proximity on discrete trials; however, such paradigms do not match well with the continuous performance situations more typically encountered outside the laboratory. As a result, the stages of information processing that are affected during multisensory continuous dual tasks and how these changes in processing relate to behavior remain unclear. To address these issues, participants were presented simultaneous rapid visual and auditory stimulus sequences under three conditions: attend visual only, attend auditory only, and dual attention (attend both visual and auditory). Performance, measured in terms of response time and perceptual sensitivity (d'), revealed dual-task impairments only in the auditory task. Neural activity, measured by the ERP technique, revealed that both early stage sensory processing and later cognitive processing of the auditory task were affected by dual-task performance, but similar stages of processing of the visual task were not. Critically, individual differences in neural activity at both early and late stages of information processing accurately rank-ordered individuals based on the observed difference in behavioral performance between the single and dual attention conditions. These results reveal relationships between behavioral performance and the neural correlates of both early and late stage information processing that provide key insights into the complex interplay between the brain and behavior when multiple tasks are performed continuously. C1 [Kasper, Ryan W.; Cecotti, Hubert; Eckstein, Miguel P.; Giesbrecht, Barry] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA. [Touryan, Jon] US Army Res Lab, Adelphi, MD USA. RP Kasper, RW (reprint author), Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA. EM kasper@psych.ucsb.edu FU Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-D-0001] FX This research was supported by the Institute for Collaborative Biotechnologies through contract W911NF-09-D-0001 from the U.S. Army Research Office. NR 53 TC 8 Z9 8 U1 0 U2 14 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 0898-929X EI 1530-8898 J9 J COGNITIVE NEUROSCI JI J. Cogn. Neurosci. PD MAR PY 2014 VL 26 IS 3 BP 476 EP 489 DI 10.1162/jocn_a_00480 PG 14 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA AJ8QV UT WOS:000337972600003 PM 24047391 ER PT J AU Moran, JM Jolly, E Mitchell, JP AF Moran, Joseph M. Jolly, Eshin Mitchell, Jason P. TI Spontaneous Mentalizing Predicts the Fundamental Attribution Error SO JOURNAL OF COGNITIVE NEUROSCIENCE LA English DT Article ID MEDIAL PREFRONTAL CORTEX; TEMPORO-PARIETAL JUNCTION; FUNCTIONAL CONNECTIVITY; SOCIAL COGNITION; BRAIN; FMRI; KNOWLEDGE; BEHAVIOR; AUTISM; MINDS AB When explaining the reasons for others' behavior, perceivers often overemphasize underlying dispositions and personality traits over the power of the situation, a tendency known as the fundamental attribution error. One possibility is that this bias results from the spontaneous processing of others' mental states, such as their momentary feelings or more enduring personality characteristics. Here, we use fMRI to test this hypothesis. Participants read a series of stories that described a target's ambiguous behavior in response to a specific social situation and later judged whether that act was attributable to the target's internal dispositions or to external situational factors. Neural regions consistently associated with mental state inference-especially, the medial pFC-strongly predicted whether participants later made dispositional attributions. These results suggest that the spontaneous engagement of mentalizing may underlie the biased tendency to attribute behavior to dispositional over situational forces. C1 [Moran, Joseph M.; Jolly, Eshin; Mitchell, Jason P.] Harvard Univ, Cambridge, MA 02138 USA. [Moran, Joseph M.] US Army Natick Soldier Res, Dev & Engn Ctr, Natick, MA USA. RP Moran, JM (reprint author), Harvard Univ, Ctr Brain Sci, 52 Oxford St,290-01, Cambridge, MA 02138 USA. EM jmoran@wjh.harvard.edu FU Harvard University FX This work was supported by a seed grant from Harvard University to J. P. M. The authors thank Diana Bartenstein and T. J. Eisenstein for assistance. NR 40 TC 1 Z9 1 U1 6 U2 30 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 0898-929X EI 1530-8898 J9 J COGNITIVE NEUROSCI JI J. Cogn. Neurosci. PD MAR PY 2014 VL 26 IS 3 BP 569 EP 576 DI 10.1162/jocn_a_00513 PG 8 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA AJ8QV UT WOS:000337972600010 PM 24168220 ER PT J AU Baloch, HM Armstrong, DT Pulling, TM Miller, LM AF Baloch, Harris M. Armstrong, David T. Pulling, Thomas M. Miller, Luke M. TI Clinical Images: Hookworm-associated reactive spondyloarthritis SO ARTHRITIS & RHEUMATOLOGY LA English DT Editorial Material C1 [Baloch, Harris M.; Armstrong, David T.; Pulling, Thomas M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Miller, Luke M.] Winn Army Community Hosp, Ft Stewart, GA USA. RP Baloch, HM (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD MAR PY 2014 VL 66 IS 3 BP 578 EP 578 DI 10.1002/art.38289 PG 1 WC Rheumatology SC Rheumatology GA AJ0QD UT WOS:000337359400013 PM 24574217 ER PT J AU Roberts, CL Meyering, CD Zychowicz, ME AF Roberts, Cindy L. Meyering, Christopher D. Zychowicz, Michael E. TI Improving the Management of Tibia Stress Fractures A Collaborative, Outpatient Clinic-Based Quality Improvement Project SO ORTHOPAEDIC NURSING LA English DT Article ID INTENSITY PULSED ULTRASOUND; MUSCULOSKELETAL DISORDERS; BONE-SCINTIGRAPHY; MILITARY RECRUITS; RISK-FACTORS; PREVENTION; DIAGNOSIS; NONUNIONS; INJURIES; CARE AB PURPOSE: Implement and evaluate the effectiveness of the Leg Pain Screening and Referral Tool (LPS&RT) for patients presenting with lower extremity leg pain in an outpatient clinic. SAMPLE: A total of 46 patients diagnosed with tibia stress fractures. METHODS: The study employed a pre-/postintervention design. Retrospective and prospective information was collected from an electronic health record to obtain patient data. The pre- and postintervention groups were compared on the number of patients diagnosed with tibia stress fractures. Provider adherence to the treatments recommended by the algorithm was assessed by chart audits postintervention. RESULTS: There was a significant increase (87.5%) in tibia stress fracture diagnosis, from 16 preintervention to 30 postintervention. Provider adherence to the LPS&RT was 93.3% postintervention. Common treatments were activity restriction, oral medication, and/or specialty referrals. CONCLUSION: The LPS&RT was an effective, uniform measure to standardize the plan of care for tibia stress fractures in one outpatient clinic. C1 [Roberts, Cindy L.] Martin Army Community Hosp, Dept Warrior Care, Ft Benning, GA 31905 USA. [Meyering, Christopher D.] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. [Zychowicz, Michael E.] Duke Univ, MSN Program, Durham, NC USA. [Zychowicz, Michael E.] Duke Univ, Orthopaed Program Lead Fac, Durham, NC USA. RP Roberts, CL (reprint author), Martin Army Community Hosp, Dept Warrior Care, Ft Benning, GA 31905 USA. NR 37 TC 1 Z9 1 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0744-6020 EI 1538-8654 J9 ORTHOP NURS JI Orthop. Nurs. PD MAR-APR PY 2014 VL 33 IS 2 BP 75 EP 83 DI 10.1097/NOR.0000000000000032 PG 9 WC Nursing; Orthopedics SC Nursing; Orthopedics GA AI9HZ UT WOS:000337245000002 PM 24651138 ER PT J AU Wang, Y Arun, P Wei, YL Oguntayo, S Gharavi, R Valiyaveettil, M Nambiar, MP Long, JB AF Wang, Ying Arun, Peethambaran Wei, Yanling Oguntayo, Samuel Gharavi, Robert Valiyaveettil, Manojkumar Nambiar, Madhusoodana P. Long, Joseph B. TI Repeated Blast Exposures Cause Brain DNA Fragmentation in Mice SO JOURNAL OF NEUROTRAUMA LA English DT Article DE apoptosis; blast-induced neurotrauma; cell-free DNA; DNA damage; mitochondria ID ADULT HIPPOCAMPAL NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; DENTATE GYRUS; NEUROPROTECTIVE EFFICACY; SELECTIVE VULNERABILITY; AMINOPROPYL CARBAZOLES; GLIAL PROLIFERATION; CELL-PROLIFERATION; COGNITIVE RECOVERY; MOUSE MODEL AB The pathophysiology of blast-induced traumatic brain injury (TBI) and subsequent behavioral deficits are not well understood. Unraveling the mechanisms of injury is critical to derive effective countermeasures against this form of neurotrauma. Preservation of the integrity of cellular DNA is crucial for the function and survival of cells. We evaluated the effect of repeated blast exposures on the integrity of brain DNA and tested the utility of cell-free DNA (CFD) in plasma as a biomarker for the diagnosis and prognosis of blast-induced polytrauma. The results revealed time-dependent breakdown in cellular DNA in different brain regions, with the maximum damage at 24 h post-blast exposures. CFD levels in plasma showed a significant transient increase, which was largely independent of the timing and severity of brain DNA damage; maximum levels were recorded at 2?h after repeated blast exposure and returned to baseline at 24?h. A positive correlation was observed between the righting reflex time and CFD level in plasma at 2?h after blast exposure. Brain DNA damage subsequent to repeated blast was associated with decreased mitochondrial membrane potential, increased release of cytochrome C, and up-regulation of caspase-3, all of which are indicative of cellular apoptosis. Shock-wave-induced DNA damage and initiation of mitochondrial-driven cellular apoptosis in the brain after repeated blast exposures indicate that therapeutic strategies directed toward inhibition of DNA damage or instigation of DNA repair may be effective countermeasures. C1 [Wang, Ying; Arun, Peethambaran; Wei, Yanling; Oguntayo, Samuel; Gharavi, Robert; Valiyaveettil, Manojkumar; Nambiar, Madhusoodana P.; Long, Joseph B.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Long, JB (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ying.wangv@us.army.mil; joseph.long@us.army.mil NR 56 TC 4 Z9 6 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 1 PY 2014 VL 31 IS 5 BP 498 EP 504 DI 10.1089/NEU.2013.3074 PG 7 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AB4ZV UT WOS:000331799600248 PM 24074345 ER PT J AU Sang, LP Majji, S Casares, S Brumeanu, TD AF Sang, Luis Pow Majji, Sai Casares, Sofia Brumeanu, Teodor D. TI Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE HLA-peptide chimera; HLA-humanized NOD mouse; T1D prevention and stabilization ID MOLECULE B7-1; II CHIMERA; BETA-CELLS; T-CELLS; TYPE-1; MICE; REVERSAL; MELLITUS; EPITOPE; ISLETS AB Several human MHC class II (HLA) molecules are strongly associated with high incidence of autoimmune diseases including type 1 diabetes (T1D). The HLA-humanized mice may thus represent valuable tools to test HLA-based vaccines and therapeutics for human autoimmune diseases. Herein, we have tested the therapeutic potential of a soluble HLA-DR4-GAD65(271-280) (hu DEF-GAD65) chimera of human use in a newly-generated NOD/DR4/B7 double transgenic (dTg) mouse that develops spontaneously an accelerated T1D regardless the gender. The NOD/DR4/B7 dTg mice generated by a two-step crossing protocol express the HLA-DR*0401 molecules on 20% of antigen presenting cells, the human B7 molecules in pancreas, and HLA-DR4/GAD65-specific T-cells in the blood. Some 75% of pre-diabetic NOD/DR4/B7 dTg mice treated with hu DEF-GAD65 chimera remained euglycemic and showed a stabilized pancreatic insulitis 6 months after treatment. The 25% non responders developing hyperglycemia survived 3-4 months longer than their untreated littermates. T1D prevention by this reagent occurred by a Th2/TR-1 polarization in the pancreas. This study strongly suggests that the use of soluble pHLA reagents to suppress/stabilize the T1D progression and to extend the life expectancy in the absence of side effects is an efficient and safe therapeutic approach. C1 [Sang, Luis Pow; Casares, Sofia; Brumeanu, Teodor D.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Immunol, F Edward Herbert Sch Med, Bethesda, MD 20814 USA. [Majji, Sai; Casares, Sofia] Walter Reed Army Inst Res, Naval Med Res Ctr, Infect Dis Directorate Malaria Program, Silver Spring, MD USA. RP Brumeanu, TD (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Div Immunol, F Edward Herbert Sch Med, Room A3060, Bethesda, MD 20814 USA. EM teodor-doru.brumeanu@usuhs.edu FU USUHS grant [RO83ZK]; JDRF grant FX This work was supported by an USUHS grant (#RO83ZK) to Brumeanu TD, and a JDRF grant to Casares S and Brumeanu TD. We thank Mrs Margaret Kehl and Jacqueline Surls for assistance with mice care and Luminex assays. NR 23 TC 1 Z9 1 U1 0 U2 1 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAR PY 2014 VL 10 IS 3 BP 693 EP 699 DI 10.4161/hv.27374 PG 7 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AI1ZF UT WOS:000336653800033 ER PT J AU Vose, RS Applequist, S Bourassa, MKA Pryor, SC Barthelmie, RJ Blanton, B Bromirski, PD Brooks, HOE DeGaetano, AT Dole, RM Easterling, DR Jensen, RE Karl, TR Katz, RW Klink, K Kruk, MC Kunkel, KE MacCracken, MC Peterson, TSC Shein, K Thomas, BR Walsh, JE Wang, XLL Wehner, MF Wuebbles, DJ Young, RS AF Vose, Russell S. Applequist, Scott Bourassa, Mar K. A. Pryor, Sara C. Barthelmie, Rebecca J. Blanton, Brian Bromirski, Peter D. Brooks, Harold E. DeGaetano, Arthur T. Dole, Randall M. Easterling, David R. Jensen, Robert E. Karl, Thomas R. Katz, Richard W. Klink, Katherine Kruk, Michael C. Kunkel, Kenneth E. MacCracken, Michael C. Peterson, Thoma S. C. Shein, Karsten Thomas, Bridget R. Walsh, John E. Wang, Xiaolan L. Wehner, Michael F. Wuebbles, Donald J. Young, Robert S. TI MONITORING AND UNDERSTANDING CHANGES IN EXTREMES SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID EXTRATROPICAL CYCLONE ACTIVITY; US EAST-COAST; WAVE HEIGHTS; WIND-SPEED; CLIMATE CONTROLS; GLOBAL TRENDS; UNITED-STATES; REANALYSIS; VARIABILITY; CIRCULATION AB This scientific assessment examines changes in three climate extremesextratropical storms, winds, and waveswith an emphasis on U.S. coastal regions during the cold season. There is moderate evidence of an increase in both extratropical storm frequency and intensity during the cold season in the Northern Hemisphere since 1950, with suggestive evidence of geographic shifts resulting in slight upward trends in offshore/coastal regions. There is also suggestive evidence of an increase in extreme winds (at least annually) over parts of the ocean since the early to mid-1980s, but the evidence over the U.S. land surface is inconclusive. Finally, there is moderate evidence of an increase in extreme waves in winter along the Pacific coast since the 1950s, but along other U.S. shorelines any tendencies are of modest magnitude compared with historical variability. The data for extratropical cyclones are considered to be of relatively high quality for trend detection, whereas the data for extreme winds and waves are judged to be of intermediate quality. In terms of physical causes leading to multidecadal changes, the level of understanding for both extratropical storms and extreme winds is considered to be relatively low, while that for extreme waves is judged to be intermediate. Since the ability to measure these changes with some confidence is relatively recent, understanding is expected to improve in the future for a variety of reasons, including increased periods of record and the development of climate reanalysis projects. C1 [Vose, Russell S.; Applequist, Scott; Easterling, David R.; Karl, Thomas R.; Peterson, Thoma S. C.; Shein, Karsten] NOAA, Natl Climat Data Ctr, Asheville, NC 28801 USA. [Bourassa, Mar K. A.] Florida State Univ, Ctr Ocean Atmosphere Predict Studies, Tallahassee, FL 32306 USA. [Barthelmie, Rebecca J.] Indiana Univ, Dept Geol Sci, Bloomington, IN 47405 USA. [Blanton, Brian] Renaissance Comp Inst, Chapel Hill, NC USA. [Bromirski, Peter D.] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. [Brooks, Harold E.] NOAA, Natl Severe Storms Lab, Norman, OK 73069 USA. [DeGaetano, Arthur T.] Cornell Univ, Northeast Reg Climate Ctr, Ithaca, NY USA. [Dole, Randall M.] NOAA, Earth Syst Res Lab, Boulder, CO USA. [Jensen, Robert E.] US Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS USA. [Katz, Richard W.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Klink, Katherine] Univ Minnesota, Dept Geog, Minneapolis, MN 55455 USA. [Kruk, Michael C.] Earth Resources Technol Inc, Asheville, NC USA. [Kunkel, Kenneth E.] Cooperat Inst Climate & Satellites, Asheville, NC USA. [MacCracken, Michael C.] Climate Inst, Washington, DC USA. [Thomas, Bridget R.; Wang, Xiaolan L.] Environm Canada, Div Climate Res, Dartmouth, NS, Canada. [Walsh, John E.] Univ Alaska Fairbanks, Fairbanks, AK USA. [Wehner, Michael F.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Wuebbles, Donald J.] Univ Illinois, Dept Atmospher Sci, Urbana, IL USA. [Young, Robert S.] Western Carolina Univ, Dept Geosci & Nat Resources, Cullowhee, NC 28723 USA. RP Vose, RS (reprint author), NOAA, Natl Climat Data Ctr, 151 Patton Ave, Asheville, NC 28801 USA. EM russell.vose@noaa.gov RI Kunkel, Kenneth/C-7280-2015; Katz, Richard/K-4133-2012; OI Kunkel, Kenneth/0000-0001-6667-7047; Katz, Richard/0000-0002-0267-8953; Barthelmie, Rebecca J/0000-0003-0403-6046; Klink, Katherine/0000-0002-0377-2378 NR 54 TC 13 Z9 15 U1 7 U2 39 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD MAR PY 2014 VL 95 IS 3 BP 377 EP 386 DI 10.1175/BAMS-D-12-00162.1 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AG1TE UT WOS:000335198200005 ER PT J AU Oostrom, M Truex, MJ Rice, AK Johnson, CD Carroll, KC Becker, DJ Simon, MA AF Oostrom, M. Truex, M. J. Rice, A. K. Johnson, C. D. Carroll, K. C. Becker, D. J. Simon, M. A. TI Estimating the Impact of Vadose Zone Sources on Groundwater to Support Performance Assessment of Soil Vapor Extraction SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article ID MASS FLUX; HYDRAULIC CONDUCTIVITY; CONTAMINANT VAPORS; POROUS-MEDIA; MODEL; WATER; INTRUSION; TRANSPORT; CLOSURE; NAPL AB Soil vapor extraction (SVE) is a prevalent remediation remedy for volatile organic compound (VOC) contaminants in the vadose zone. To support selection of an appropriate condition at which SVE may be terminated for site closure or for transition to another remedy, an evaluation is needed to determine whether vadose zone VOC contamination has been diminished sufficiently to keep groundwater concentrations below threshold values. A conceptual model for this evaluation was developed for VOC fate and transport from a vadose zone source to groundwater when vapor-phase diffusive transport is the dominant transport process. A numerical analysis showed that, for these conditions, the groundwater concentration is controlled by a limited set of parameters, including site-specific dimensions, vadose zone properties, and source characteristics. On the basis of these findings, a procedure was then developed for estimating groundwater concentrations using results from the three-dimensional multiphase transport simulations for a matrix of parameter value combinations and covering a range of potential site conditions. Interpolation and scaling processes are applied to estimate groundwater concentrations at compliance (monitoring) wells for specific site conditions of interest using the data from the simulation results. The interpolation and scaling methodology using these simulation results provides a far less computationally intensive alternative to site-specific three-dimensional multiphase site modeling, while still allowing for parameter sensitivity and uncertainty analyses. With iterative application, the approach can be used to consider the effect of a diminishing vadose zone source over time on future groundwater concentrations. This novel approach and related simulation results have been incorporated into a user-friendly Microsoft (R) Excel (R)-based spreadsheet tool entitled SVEET (Soil Vapor Extraction Endstate Tool), which has been made available to the public. C1 [Oostrom, M.; Truex, M. J.; Rice, A. K.; Johnson, C. D.; Carroll, K. C.] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. [Becker, D. J.] US Army Corps Engineers, Environm & Munit Ctr Expertise, Omaha, NE 68102 USA. [Simon, M. A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Oostrom, M (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, POB 999,MS K6-96, Richland, WA 99354 USA. EM mart.oostrom@pnnl.gov RI Carroll, Kenneth/H-5160-2011 OI Carroll, Kenneth/0000-0003-2097-9589 FU U.S. Department of Energy's Office of Environmental Management; U.S. Department of Energy [DE-AC05-76RL01830] FX Funding for this work was provided by the U.S. Department of Energy's Office of Environmental Management. The Pacific Northwest National Laboratory is operated by Battelle Memorial Institute for the U.S. Department of Energy under Contract DE-AC05-76RL01830. The SVEET tool can be downloaded at http://bioprocess.pnnl.gov/SVEET_Request.htm. NR 39 TC 0 Z9 0 U1 2 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-3629 EI 1745-6592 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SPR PY 2014 VL 34 IS 2 BP 72 EP 85 DI 10.1111/gwmr.12050 PG 14 WC Water Resources SC Water Resources GA AH6BU UT WOS:000336216500006 ER PT J AU Wang, CX Granskog, MA Gerland, S Hudson, SR Perovich, DK Nicolaus, M Karlsen, TI Fossan, K Bratrein, M AF Wang, Caixin Granskog, Mats A. Gerland, Sebastian Hudson, Stephen R. Perovich, Donald K. Nicolaus, Marcel Karlsen, Tor Ivan Fossan, Kristen Bratrein, Marius TI Autonomous observations of solar energy partitioning in first-year sea ice in the Arctic Basin SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE solar energy partition; sea ice; autonomous observation; high Arctic ID OPTICAL-PROPERTIES; MASS-BALANCE; TEMPORAL EVOLUTION; MELT; ALBEDO; TRANSMISSION; VARIABILITY; RADIATION; THICKNESS; BUDGET AB A Spectral Radiation Buoy (SRB) was developed to autonomously measure the spectral incident, reflected, and transmitted spectral solar radiation (350-800 nm) above and below sea ice. The SRB was deployed on drifting first-year sea ice near the North Pole in mid-April 2012, together with velocity and ice mass balance buoys. The buoys drifted southward and reached Fram Strait after approximately 7 months, covering a complete melt season. At the SRB site, snowmelt started on 10 June, and had completely disappeared by 14 July. Surface albedo was above 0.85 until snowmelt onset and decreased rapidly with the progression of snowmelt. Albedo was lowest on 14 July, when the observed surface was likely a mixture of bare ice and melt pond(s). The transmitted irradiance measured under the ice was largest in July, with a monthly average of 20 W m(-2), compared to <0.3 W m(-2) premelt. Under-ice irradiance peaked on 19-20 July, with a daily average around 35 W m(-2). From mid-April to mid-September, the solar energy transmitted through the ice into the ocean contributed about two-thirds of the energy required for the observed bottom melt (0.49 m). The energy absorbed by the ice after snowmelt was enough to melt an additional 0.1 m of ice. Solar energy incident on open water and melt ponds provided significant additional heating, indicating solar heating could explain all of the observed bottom melt in this region in summer 2012. Key Points Autonomous sea ice albedo setup was developed and deployed in high Arctic Strong influence of sky and surface conditions variation on absorbed energy Solar heat could explain all of the observed snow and sea ice melt in 2012 C1 [Wang, Caixin; Granskog, Mats A.; Gerland, Sebastian; Hudson, Stephen R.; Karlsen, Tor Ivan; Fossan, Kristen; Bratrein, Marius] Fram Ctr, Norwegian Polar Inst, Tromso, Norway. [Perovich, Donald K.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Nicolaus, Marcel] Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Bremerhaven, Germany. RP Wang, CX (reprint author), Fram Ctr, Norwegian Polar Inst, Tromso, Norway. EM caixin.wang@npolar.no OI Nicolaus, Marcel/0000-0003-0903-1746 FU Research Council of Norway [193592, 197236]; ACCESS, a European project within the Ocean of Tomorrow call of the European Commission Seventh Framework Programme [265863]; Norwegian Polar Institute and its Centre for Ice, Climate and Ecosystems (ICE) FX The authors are grateful to Jago Wallenschus (NPI) for participation in the installation of the instruments at Barneo. We also wish to thank Cyril Dempsey (Satlantic) for assistance with the datalogger, radiometers, and data processing, Frank Nilsen (UNIS) and the captain and crew of the RV Lance for the recovery of the SRB, and scientists from the University of Washington for sharing webcam photos. Tonu Martma (TUT) is gratefully acknowledged for measuring the oxygen isotope samples. The study was supported by the Research Council of Norway through the projects "AMORA'' (project 193592) and "RATHARC'' (197236), and by ACCESS, a European project within the Ocean of Tomorrow call of the European Commission Seventh Framework Programme, grant 265863, and Norwegian Polar Institute and its Centre for Ice, Climate and Ecosystems (ICE). NR 46 TC 9 Z9 9 U1 2 U2 18 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR PY 2014 VL 119 IS 3 BP 2066 EP 2080 DI 10.1002/2013JC009459 PG 15 WC Oceanography SC Oceanography GA AE2PT UT WOS:000333816100032 ER PT J AU Cunningham, TL Cartagena, CM Lu, XCM Konopko, M Dave, JR Tortella, FC Shear, DA AF Cunningham, Tracy L. Cartagena, Casandra M. Lu, Xi-Chun M. Konopko, Melissa Dave, Jitendra R. Tortella, Frank C. Shear, Deborah A. TI Correlations between Blood-Brain Barrier Disruption and Neuroinflammation in an Experimental Model of Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE blood-brain barrier dysfunction; inflammation; penetrating brain injury; PBBI; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; FLUID PERCUSSION INJURY; POSITRON-EMISSION-TOMOGRAPHY; CENTRAL-NERVOUS-SYSTEM; ANXIETY-PRONE SUBJECTS; NECROSIS-FACTOR-ALPHA; FUNCTIONAL NEUROANATOMY; PSYCHIATRIC-DISORDERS; INFLAMMATORY RESPONSE; PREFRONTAL CORTEX AB Blood-brain barrier (BBB) disruption is a pathological hallmark of severe traumatic brain injury (TBI) and is associated with neuroinflammatory events contributing to brain edema and cell death. The goal of this study was to elucidate the profile of BBB disruption after penetrating ballistic-like brain injury (PBBI) in conjunction with changes in neuroinflammatory markers. Brain uptake of biotin-dextran amine (BDA; 3kDa) and horseradish peroxidase (HRP; 44kDa) was evaluated in rats at 4h, 24h, 48h, 72h, and 7 days post-PBBI and compared with the histopathologic and molecular profiles for inflammatory markers. BDA and HRP both displayed a uniphasic profile of extravasation, greatest at 24h post-injury and which remained evident out to 48h for HRP and 7 days for BDA. This profile was most closely associated with markers for adhesion (mRNA for intercellular adhesion molecule-1) and infiltration of peripheral granulocytes (mRNA for matrix metalloproteinase-9 [MMP-9] and myeloperoxidase staining). Improvement of BBB dysfunction coincided with increased expression of markers implicated in tissue remodeling and repair. The results of this study reveal a uniphasic and gradient opening of the BBB after PBBI and suggest MMP-9 and resident inflammatory cell activation as candidates for future neurotherapeutic intervention after PBBI. C1 [Cunningham, Tracy L.; Cartagena, Casandra M.; Lu, Xi-Chun M.; Konopko, Melissa; Dave, Jitendra R.; Tortella, Frank C.; Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA. RP Cunningham, TL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Tracy.L.Cunningham2.ctr@us.army.mil OI Konopko, Melissa/0000-0001-9515-398X NR 109 TC 8 Z9 8 U1 2 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 1 PY 2014 VL 31 IS 5 BP 505 EP 514 DI 10.1089/neu.2013.2965 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AB4ZV UT WOS:000331799600249 PM 24138024 ER PT J AU Mondello, S Schmid, K Tortella, FC Glass, L AF Mondello, Stefania Schmid, Kara Tortella, Frank C. Glass, Larry TI EMPLOYING BLOOD BIOMARKERS IN TBI CLINICAL TRIALS: FINDINGS FROM THE INTREPID2566 TRIAL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 11th Symposium of the International-Neurotrauma-Society CY MAR 19-23, 2014 CL Budapest, HUNGARY SP Int Neurotrauma Soc C1 [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD USA. [Glass, Larry] Neuren Pharmaceut Ltd, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 1 PY 2014 VL 31 IS 5 MA 113 BP A34 EP A34 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AB4ZV UT WOS:000331799600114 ER PT J AU Mondello, S Shear, DA Bramlett, HM Dixon, EC Schmid, K Dietrich, WD Wang, KKW Hayes, RL Tortella, FC Kochanek, PM AF Mondello, Stefania Shear, Deborah A. Bramlett, Helen M. Dixon, Edward C. Schmid, Kara Dietrich, W. Dalton Wang, Kevin K. W. Hayes, Ronald L. Tortella, Frank C. Kochanek, Patrick M. TI CHARACTERIZATION OF TBI MODELS AND EVALUATION OF EFFICACY OF NICOTINAMIDE, ERYTHROPOIETIN, AND CYCLOSPORIN A USING SERUM BIOMARKERS: RESULTS FROM OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 11th Symposium of the International-Neurotrauma-Society CY MAR 19-23, 2014 CL Budapest, HUNGARY SP Int Neurotrauma Soc C1 [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Shear, Deborah A.; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami, FL 33136 USA. [Dixon, Edward C.; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. [Wang, Kevin K. W.] Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Dept Clin Programs, Alachua, FL USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 1 Z9 1 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 1 PY 2014 VL 31 IS 5 MA 114 BP A35 EP A35 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AB4ZV UT WOS:000331799600115 ER PT J AU Gold, LI Pavlides, SC Ojeda, J Eaton, B Panchal, RG AF Gold, L. I. Pavlides, S. C. Ojeda, J. Eaton, B. Panchal, R. G. TI A NEW ROLE FOR THE MULTIFUNCTIONAL WOUND HEALING AGENT CALRETICULIN (CRT) IN COMBATING INFECTION: SIGNIFICANCE FOR TREATING DIABETIC FOOT ULCERS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Gold, L. I.; Pavlides, S. C.] NYU, Sch Med, New York, NY USA. [Ojeda, J.; Eaton, B.; Panchal, R. G.] US Army, Med Res, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR PY 2014 VL 22 IS 2 BP A42 EP A42 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA AC9DV UT WOS:000332835400060 ER PT J AU Cancio, LC Serio-Melvin, M Garcia, A Salinas, J AF Cancio, Leopoldo C. Serio-Melvin, Maria Garcia, Ada Salinas, Jose TI Electronic Medical Records for Burn Centers: What Do Users Need? SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID HEALTH; ERRORS C1 [Cancio, Leopoldo C.; Serio-Melvin, Maria; Garcia, Ada; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), US Army Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. FU Comprehensive ICU Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland FX Funded by the Comprehensive ICU Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 10 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2014 VL 35 IS 2 BP 134 EP 135 PG 2 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AB0AS UT WOS:000331454800011 PM 23511291 ER PT J AU Nam, JJ Chung, KK King, BT Jones, JA Cancio, LC Baer, DG Renz, EM Blackbourne, LH Orman, JA AF Nam, Jason J. Chung, Kevin K. King, Booker T. Jones, John A. Cancio, Leopoldo C. Baer, David G. Renz, Evan M. Blackbourne, Lorne H. Orman, Jean A. TI Citation Classics in the Burn Literature During the Past 55 Years SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID OPERATION IRAQI FREEDOM; CARBOHYDRATE-METABOLISM; ENDURING FREEDOM; THERMAL-INJURY; TRAUMA; KINETICS C1 [Nam, Jason J.] Georgetown Univ, Sch Med, Washington, DC USA. [Chung, Kevin K.; King, Booker T.; Jones, John A.; Cancio, Leopoldo C.; Baer, David G.; Renz, Evan M.] US Army Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.; Renz, Evan M.; Orman, Jean A.] Uniformed Serv Univ Hlth Sci, Dept Med, Washington, DC USA. [Blackbourne, Lorne H.] US Army Trauma Training Ctr, Miami, FL USA. [Orman, Jean A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Orman, Jean A.] Univ Texas Sch Publ Hlth, Dept Epidemiol, San Antonio, TX USA. RP Chung, KK (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. NR 18 TC 2 Z9 2 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2014 VL 35 IS 2 BP 176 EP 185 PG 10 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AB0AS UT WOS:000331454800019 PM 23799479 ER PT J AU Zheng, JH Zhang, C Demirbilek, Z Lin, LW AF Zheng, Jinhai Zhang, Chi Demirbilek, Zeki Lin, Lihwa TI Numerical Study of Sandbar Migration under Wave-Undertow Interaction SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article ID INDUCED SEDIMENT TRANSPORT; SHEAR-STRESS; SURF ZONE; MODEL; BEACHES; VELOCITIES; TURBULENCE; EVOLUTION; FLOW C1 [Zheng, Jinhai; Zhang, Chi] Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. [Demirbilek, Zeki; Lin, Lihwa] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Zheng, JH (reprint author), Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. EM jhzheng@hhu.edu.cn FU National Natural Science Foundation of China [51209082, 51379071]; National Key Basic Research Development Program "973 Project" of China [2010CB429002]; National Key Technology Research and Development Program [2012BAB03B01]; 111 Project [B12032]; Qin Lan Project of Jiangsu Province [BRA2012130]; 333 Project of Jiangsu Province [BRA2012130] FX The authors gratefully acknowledge the O. H. Hinsdale Wave Research Laboratory at Oregon State University and Gregory Guannel for publishing the CROSSTEX experimental data, which were used for numerical model validation in this study. This work was supported by the National Natural Science Foundation of China (Grant No. 51209082, 51379071), the National Key Basic Research Development Program "973 Project" of China (Grant No. 2010CB429002), the National Key Technology Research and Development Program (Grant No. 2012BAB03B01), the 111 Project (Grant No. B12032), and the Qin Lan Project and 333 Project of Jiangsu Province (Grant No. BRA2012130). Zeki Demirbilek and Lihwa Lin are grateful for the technical support received in this activity from the U.S. Army Corps of Engineers Coastal Inlets Research Program (CIRP). The USACE Headquarters granted permission to publish this paper. NR 31 TC 3 Z9 4 U1 3 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD MAR 1 PY 2014 VL 140 IS 2 BP 146 EP 159 PG 14 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA AA9WB UT WOS:000331442600004 ER PT J AU McGann, P Courvalin, P Snesrud, E Clifford, RJ Yoon, EJ Onmus-Leone, F Ong, AC Kwak, YI Grillot-Courvalin, C Lesho, E Waterman, PE AF McGann, Patrick Courvalin, Patrice Snesrud, Erik Clifford, Robert J. Yoon, Eun-Jeong Onmus-Leone, Fatma Ong, Ana C. Kwak, Yoon I. Grillot-Courvalin, Catherine Lesho, Emil Waterman, Paige E. TI Amplification of Aminoglycoside Resistance Gene aphA1 in Acinetobacter baumannii Results in Tobramycin Therapy Failure SO MBIO LA English DT Article ID ANTIBIOTIC-RESISTANCE; SALMONELLA-TYPHIMURIUM; VANCOMYCIN RESISTANCE; STAPHYLOCOCCUS-AUREUS; MULTIDRUG-RESISTANCE; FITNESS COST; EVOLUTION; DUPLICATION; EXPRESSION; DIVERSITY AB Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature. We report a rise in MICs from 0.5 to 16 mu g/ml in successive Acinetobacter baumannii isolated over 4 days from a patient being treated with tobramycin for an infection by multidrug-resistant A. baumannii, resulting in therapeutic failure. Isolates were characterized by whole-genome sequencing, real-time and reverse transcriptase PCR, and growth assays to determine the mechanism of tobramycin resistance and its fitness cost. Tobramycin resistance was associated with two amplification events of different chromosomal fragments containing the aphA1 aminoglycoside resistance gene part of transposon Tn6020. The first amplification event involved low amplification (6 to 10 copies) of a large DNA fragment that was unstable and conferred tobramycin MICs of <= 8 mu g/ml. The second event involved moderate (10 to 30 copies) or high (40 to 110 copies) amplification of Tn6020. High copy numbers were associated with tobramycin MICs of 16 mu g/ml, impaired fitness, and genetic instability, whereas lower copy numbers resulted in tobramycin MICs of <= 8 mu g/ml and no fitness cost and were stably maintained in vitro. Exposure in vitro to tobramycin of the initial susceptible isolate and of the A. baumannii AB0057 reference strain led to similar aphA1 amplifications and elevated tobramycin MICs. To the best of our knowledge, this is the first report of in vivo development of antibiotic resistance secondary to gene amplifications resulting in therapy failure. IMPORTANCE A combination of whole-genome sequencing and mapping were used to detect an antibiotic resistance mechanism, gene amplification, which has been presumed for a long time to be of major importance but has rarely been reported in clinical settings because of its unstable nature. Two gene amplification events in a patient with an Acinetobacter baumannii infection treated with tobramycin were identified. One gene amplification event led to high levels of resistance and was rapidly reversible, while the second event led to low and more stable resistance since it incurred low fitness cost on the host. Gene amplification, with an associated rise in tobramycin MICs, could be readily reproduced in vitro from initially susceptible strains exposed to increasing concentrations of tobramycin, suggesting that gene amplification in A. baumannii may be a more common mechanism than currently believed. This report underscores the importance of rapid molecular techniques for surveillance of drug resistance. C1 [McGann, Patrick; Snesrud, Erik; Clifford, Robert J.; Onmus-Leone, Fatma; Ong, Ana C.; Kwak, Yoon I.; Lesho, Emil; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Courvalin, Patrice; Yoon, Eun-Jeong; Grillot-Courvalin, Catherine] Inst Pasteur, Unite Agents Antibacteriens, Paris, France. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann4.ctr@mail.mil; patrice.courvalin@pasteur.fr FU U.S. Army Medical Command; Global Emerging Infections Surveillance and Response System; Defense Medical Research and Development Program; European Union FP7-PAR grant FX This study was funded by the U.S. Army Medical Command, the Global Emerging Infections Surveillance and Response System, and the Defense Medical Research and Development Program. This work was supported in part by the European Union FP7-PAR grant, which included a fellowship in support of E-J. Yoon. NR 37 TC 9 Z9 9 U1 3 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAR-APR PY 2014 VL 5 IS 2 AR e00915-14 DI 10.1128/mBio.00915-14 PG 8 WC Microbiology SC Microbiology GA AH1XR UT WOS:000335915600035 PM 24757213 ER PT J AU von Cresce, A Russell, SM Baker, DR Gaskell, KJ Xu, K AF v. Cresce, Arthur Russell, Selena M. Baker, David R. Gaskell, Karen J. Xu, Kang TI In Situ and Quantitative Characterization of Solid Electrolyte Interphases SO NANO LETTERS LA English DT Article DE Interphase; SEI; in situ characterization; HOPG; Li ion battery; electrolyte; AFM ID LITHIUM-ION BATTERIES; SURFACE-FILM FORMATION; GRAPHITE NEGATIVE ELECTRODE; ATOMIC-FORCE MICROSCOPY; RAY PHOTOELECTRON-SPECTROSCOPY; PROPYLENE CARBONATE SOLUTIONS; ORIENTED PYROLYTIC-GRAPHITE; VINYLENE CARBONATE; EDGE PLANE; LI-ION AB Despite its importance in dictating electrochemical reversibility and cell chemistry kinetics, the solid electrolyte interphase (SEI) on graphitic anodes remains the least understood component in Li ion batteries due to its trace presence, delicate chemical nature, heterogeneity in morphology, elusive formation mechanism, and lack of reliable in situ quantitative tools to characterize it. This work summarizes our systematic approach to understand SEI live formation, via in situ electrochemical atomic force microscopy, which provides topographic images and quantitative information about the structure, hierarchy, and thickness of interphases as function of electrolyte composition. Complemented by an ex situ chemical analysis, a comprehensive and dynamic picture of interphase formation during the first lithiation cycle of the graphitic anode is described. This combined approach provides an in situ and quantitative tool to conduct quality control of formed interphases. C1 [v. Cresce, Arthur; Russell, Selena M.; Baker, David R.; Xu, Kang] US Army Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch, Power & Energy Div, Adelphi, MD 20783 USA. [Gaskell, Karen J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. RP Xu, K (reprint author), US Army Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch, Power & Energy Div, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil RI Gaskell, Karen/H-8270-2014 FU Department of Energy Applied Battery Research (DOE-ABR) Program; U.S. Army Research Laboratory Postdoctoral Fellowship Program; U.S. Army Research Laboratory FX The authors thank Dr. Kyle N. Grew (ARL) for assistance in composing a MATLAB routine to analyze AFM F-d data. Partial financial support from Department of Energy Applied Battery Research (DOE-ABR) Program is appreciated. This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. NR 43 TC 17 Z9 17 U1 11 U2 154 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD MAR PY 2014 VL 14 IS 3 BP 1405 EP 1412 DI 10.1021/nl404471v PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AG9EA UT WOS:000335720300048 ER PT J AU DiBello, K Boyar, K Abrenica, S AF DiBello, Karol Boyar, Karyn Abrenica, Silas TI Effectiveness of Text Messaging and Treatment Adherence Among Adults 18-45 Years of Age Diagnosed With Asthma SO NURSING RESEARCH LA English DT Meeting Abstract C1 [DiBello, Karol] Pace Univ, New York, NY USA. [Boyar, Karyn] NYU, Coll Nursing, New York, NY 10003 USA. [Abrenica, Silas] US Army, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-6562 EI 1538-9847 J9 NURS RES JI Nurs. Res. PD MAR-APR PY 2014 VL 63 IS 2 BP E37 EP E37 PG 1 WC Nursing SC Nursing GA AE6JP UT WOS:000334098000103 ER PT J AU Silvis, A Ford, WM Britzke, ER Johnson, JB AF Silvis, Alexander Ford, W. Mark Britzke, Eric R. Johnson, Joshua B. TI Association, roost use and simulated disruption of Myotis septentrionalis maternity colonies SO BEHAVIOURAL PROCESSES LA English DT Article DE Maternity colony; Myotis septentrionalis; Network; Roost loss ID FEMALE BECHSTEINS BATS; FISSION-FUSION SOCIETIES; SOCIAL NETWORK ANALYSIS; HOME-RANGE SIZE; INFORMATION-TRANSFER; EPTESICUS-FUSCUS; FOREST; SELECTION; DYNAMICS; PATTERNS AB How wildlife social and resource networks are distributed on the landscape and how animals respond to resource loss are important aspects of behavioral ecology. For bats, understanding these responses may improve conservation efforts and provide insights into adaptations to environmental conditions. We tracked maternity colonies of northern bats (Myotis septentrionalis) at Fort Knox, Kentucky, USA to evaluate their social and resource networks and space use. Roost and social network structure differed between maternity colonies. Overall roost availability did not appear to be strongly related to network characteristics or space use. In simulations for our two largest networks, roost removal was related linearly to network fragmentation; despite this, networks were relatively robust, requiring removal of >20% of roosts to cause network fragmentation. Results from our analyses indicate that northern bat behavior and space use may differ among colonies and potentially across the maternity season. Simulation results suggest that colony social structure is robust to fragmentation caused by random loss of small numbers of roosts. Flexible social dynamics and tolerance of roost loss may be adaptive strategies for coping with ephemeral conditions in dynamic forest habitats. (C) 2014 Elsevier B.V. All rights reserved. C1 [Silvis, Alexander; Ford, W. Mark] Virginia Polytech Inst & State Univ, Dept Fish & Wildlife Conservat, Blacksburg, VA 24061 USA. [Ford, W. Mark] US Geol Survey, Virginia Cooperat Fish & Wildlife Res Unit, Blacksburg, VA 24061 USA. [Britzke, Eric R.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Johnson, Joshua B.] Penn Game Commiss, Harrisburg, PA USA. RP Silvis, A (reprint author), 100 Cheatham Hall,310 West Campus Dr, Blacksburg, VA 24061 USA. EM silvis@vt.edu OI Silvis, Alexander/0000-0003-1163-0123 FU US Army Environmental Quality and Installation Basic Research 6.1 program FX This research was supported by the US Army Environmental Quality and Installation Basic Research 6.1 program. We thank Jimmy Watkins, Mike Brandenberg and Charlie Logsdon for their assistance in supporting this project. The Kentucky Department of Fish and Wildlife Resources graciously provided field housing for this project. We thank James Fraser, James Parkhurst, Michael Whitby, M. Brock Fenton, Meryl Friedrich, and several anonymous reviewers for comments that improved this manuscript. Use of trade, product or firm names does not imply endorsement by the US government. NR 64 TC 7 Z9 7 U1 1 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-6357 EI 1872-8308 J9 BEHAV PROCESS JI Behav. Processes PD MAR PY 2014 VL 103 BP 283 EP 290 DI 10.1016/j.beproc.2014.01.016 PG 8 WC Psychology, Biological; Behavioral Sciences; Zoology SC Psychology; Behavioral Sciences; Zoology GA AG7US UT WOS:000335624900041 PM 24468215 ER PT J AU Luxton, DD Thomas, EK Chipps, J Relova, RM Brown, D McLay, R Lee, TT Nakama, H Smolenski, DJ AF Luxton, David D. Thomas, Elissa K. Chipps, Joan Relova, Rona M. Brown, Daphne McLay, Robert Lee, Tina T. Nakama, Helenna Smolenski, Derek J. TI Caring letters for suicide prevention: Implementation of a multi-site randomized clinical trial in the US military and veteran affairs healthcare systems SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Suicide; Post-hospitalization; After-care; Contact; Inpatient psychiatry; Military veterans ID INTERPERSONAL-PSYCHOLOGICAL THEORY; BRIEF INTERVENTION; SERVICE MEMBERS; FOLLOW-UP; RISK; VALIDITY; BEHAVIOR; INDIVIDUALS; CONTACT; DESIRE AB Caring letters is a suicide prevention intervention that entails the sending of brief messages that espouse caring concern to patients following discharge from treatment. First tested more than four decades ago, this intervention is one of the only interventions shown in a randomized controlled trial to reduce suicide mortality rates. Due to elevated suicide risk among patients following psychiatric hospitalization and the steady increase in suicide rates among the U.S. military personnel, it is imperative to test interventions that may help prevent suicide among high-risk military personnel and veterans. This paper describes the design, methods, study protocol, and regulatory implementation processes for a multi-site randomized controlled trial that aims to evaluate the effectiveness of a caring emails intervention for suicide prevention in the military and VA healthcare systems. The primary outcome is suicide mortality rates to be determined 24 months post-discharge from index hospital stay. Healthcare re-utilization rates will also be evaluated and comprehensive data will be collected regarding suicide risk factors. Recommendations for navigating the military and VA research regulatory processes and implementing a multi-site clinical trial at military and VA hospitals are discussed. Published by Elsevier Inc. C1 [Luxton, David D.; Thomas, Elissa K.; Smolenski, Derek J.] Natl Ctr Telehlth &Technol, Tacoma, WA USA. [Luxton, David D.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Chipps, Joan] VA Western New York Healthcare Syst, Batavia, NY USA. [Relova, Rona M.; Lee, Tina T.] Stanford Univ, Palo Alto VAHCS, RPAC SPECTRUM, Stanford, CA 94305 USA. [Brown, Daphne] Landstuhl Reg Med Ctr, Landstuhl, Germany. [McLay, Robert] Navy Med Ctr San Diego, San Diego, CA USA. [Nakama, Helenna] Tripler Army Med Ctr, Honolulu, HI USA. RP Luxton, DD (reprint author), Natl Ctr Telehlth & Technol T2, Def Ctr Excellence Psychol Hlth & Traumat Brain I, Joint Base LewisMcChord, 9933 West Hayes St, Tacoma, WA 98431 USA. EM david.d.luxton.civ@mail.mil FU Department of the Army through the federal grant award [W81XWH-11-2-0123]; The Military Operational Medicine Research Programs, Fort Detrick [MD 21702-5012] FX This project is partially supported by the Department of the Army through the federal grant award, W81XWH-11-2-0123. The Military Operational Medicine Research Programs, 504 Scott Street, Fort Detrick MD 21702-5012 is the awarding and administering acquisition office. The content of this information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 33 TC 4 Z9 4 U1 2 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 EI 1559-2030 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD MAR PY 2014 VL 37 IS 2 BP 252 EP 260 DI 10.1016/j.cct2014.01.007 PG 9 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA AG7ZA UT WOS:000335636100012 PM 24473106 ER PT J AU Kiris, E Kota, KP Burnett, JC Soloveva, V Kane, CD Bavari, S AF Kiris, Erkan Kota, Krishna P. Burnett, James C. Soloveva, Veronica Kane, Christopher D. Bavari, Sina TI Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS LA English DT Review DE botulinum neurotoxin; embryonic stem cells; cell-based assays; motor neurons; high-content imaging; high-throughput screening; ELISA; MSD; phenotypic screening; drug discovery ID HUMAN INDUCED PLURIPOTENT; SPINAL MOTOR-NEURONS; DIRECTED DIFFERENTIATION; TERMINAL DOMAIN; SEROTYPE-A; IN-VITRO; TOXIN-A; MOTONEURONS; MECHANISM; RECEPTOR AB Botulinum neurotoxins (BoNTs) are exceptionally potent inhibitors of neurotransmission, causing muscle paralysis and respiratory failure associated with the disease botulism. Currently, no drugs are available to counter intracellular BoNT poisoning. To develop effective medical treatments, cell-based assays provide a valuable system to identify novel inhibitors in a time- and cost-efficient manner. Consequently, cell-based systems including immortalized cells, primary neurons and stem cell-derived neurons have been established. Stem cell-derived neurons are highly sensitive to BoNT intoxication and represent an ideal model to study the biological effects of BoNTs. Robust immunoassays are used to quantify BoNT activity and play a central role during inhibitor screening. In this review, we examine recent progress in physiologically relevant cell-based assays and high-throughput screening approaches for the identification of both direct and indirect BoNT inhibitors. C1 [Kiris, Erkan; Soloveva, Veronica; Kane, Christopher D.] Geneva Fdn, Tacoma, WA 98402 USA. [Kiris, Erkan; Soloveva, Veronica; Kane, Christopher D.; Bavari, Sina] US Army Med Res Inst Infect Dis, Div Integrated Toxicol, Frederick, MD 21702 USA. [Kiris, Erkan] FNLCR, Frederick, MD 2170 USA. [Kota, Krishna P.] PerkinElmer Inc, Waltham, MA 02451 USA. [Burnett, James C.] Leidos Biomed Res Inc, CDDG, FNLCR, Frederick, MD 21702 USA. [Burnett, James C.] FNLCR, Dev Therapeut Program, CDDG, Frederick, MD 21702 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Div Integrated Toxicol, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency; National Institutes of Health [1 R21 AI101387-01, 5 U01AI082051-05] FX This work was supported by grants from the Defense Threat Reduction Agency and National Institutes of Health (1 R21 AI101387-01 and 5 U01AI082051-05). KP Kota is an employee of PerkinElmer, the manufacturer of the Opera Confocal Microscope. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties. NR 95 TC 9 Z9 9 U1 0 U2 18 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7159 EI 1744-8352 J9 EXPERT REV MOL DIAGN JI Expert Rev. Mol. Diagn. PD MAR PY 2014 VL 14 IS 2 BP 153 EP 168 DI 10.1586/14737159.2014.867808 PG 16 WC Pathology SC Pathology GA AG3MX UT WOS:000335324700006 PM 24450833 ER PT J AU Kang, H Chang, C Saberi, H Ormiston, RA AF Kang, Hao Chang, Chongseok Saberi, Hossein Ormiston, Robert A. TI Assessment of Beam and Shell Elements for Modeling Rotorcraft Blades SO JOURNAL OF AIRCRAFT LA English DT Article ID MULTIBODY DYNAMICS AB A geometrically exact shell element is developed within the finite-element, multibody dynamics-based Rotorcraft Comprehensive Analysis System. The shell element accommodates transverse shear deformation as well as arbitrarily large displacements and rotations. The shell element is developed using an approach that allows for compatibility with other structural elements in the Rotorcraft Comprehensive Analysis System. It is validated by comparing its predictions with benchmark problems. The two-dimensional shell and one-dimensional beam finite-element analyses are compared for three typical blade configurations of varying slenderness ratio: a swept-tip blade, a blade with discontinuous chordwise elastic axis and center-of-gravity locations, and a blade with a flex beam. The purpose is to quantify the differences between two-dimensional-shell one-dimensional-beam finite elements for modeling rotor blades. There is good agreement between the one- and two-dimensional analyses in predicting the natural frequencies of straight blades with a slenderness ratio of greater than 12.5. However, there are up to 16.5% differences in frequency predictions for a slenderness ratio of 17.5 or less and a tip sweep angle of 30deg or higher. The differences increase with decreasing slenderness ratio and increasing tip sweep angle. For a blade with a discontinuous center-of-gravity offset, frequencies predicted using the two- and one-dimensional analyses show up to 12.5% difference and increase with the center-of-gravity offset. For a blade with discontinuous elastic axis offset, the frequencies predicted using the two analyses have good agreement. The differences are observed when both approaches calculate the structural loads (bending moments) and deformations of a blade with an elastic axis offset. C1 [Kang, Hao; Chang, Chongseok; Saberi, Hossein] Adv Rotorcraft Technol Inc, Sunnyvale, CA 94085 USA. [Ormiston, Robert A.] US Army Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. RP Kang, H (reprint author), US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Aeroflightdynamics Directorate under Small Business Innovation Research [W911W6-09-C-0044] FX The authors gratefully acknowledge Oliver A. Bauchau for his support in the shell element formulation. The research described in this paper was supported by the U.S. Army Aeroflightdynamics Directorate under Small Business Innovation Research contract W911W6-09-C-0044. The technical monitor was Robert A. Ormiston. NR 14 TC 2 Z9 2 U1 1 U2 3 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 EI 1533-3868 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2014 VL 51 IS 2 BP 520 EP 531 DI 10.2514/1.C032217 PG 12 WC Engineering, Aerospace SC Engineering GA AE2JD UT WOS:000333798200015 ER PT J AU Welton, MD AF Welton, Mark D. TI Modern Perspectives on Islamic Law SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SPR PY 2014 VL 68 IS 2 BP 333 EP 333 PG 1 WC Area Studies SC Area Studies GA AG2UE UT WOS:000335271800018 ER PT J AU Malcomb, DW Weaver, EA Krakowka, AR AF Malcomb, Dylan W. Weaver, Elizabeth A. Krakowka, Amy Richmond TI Vulnerability modeling for sub-Saharan Africa: An operationalized approach in Malawi SO APPLIED GEOGRAPHY LA English DT Article DE Vulnerability; Adaptive capacity; Demographic; Modeling; Malawi ID CLIMATE-CHANGE; MAPPING VULNERABILITY; ADAPTIVE CAPACITY; ADAPTATION; INSECURITY; FRAMEWORK AB This study addresses the need for a policy-relevant climatic vulnerability model in sub-Saharan Africa, where data is typically poor and people are exposed to a wide range of environmental and socioeconomic stressors that are unique to the region. This research applies a multi-scale, multi-indicator methodology that allows policy-makers and experts flexibility to contextualize causal factors in the modeling process through selection of evidence-based variables of vulnerability. This process is easily scaled to stakeholders needs, whether at a state, district or local level. This article provides a framework to assist stakeholders and policy-makers in Malawi to determine what drives vulnerability at a household level, which areas in the country are most vulnerable and where development solutions should be applied. As financial assistance related to climate adaptation increases rapidly in Africa, this article presents timely results for Malawi and an auspicious methodology that can assist other vulnerable countries. Published by Elsevier Ltd. C1 [Malcomb, Dylan W.; Weaver, Elizabeth A.; Krakowka, Amy Richmond] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Weaver, EA (reprint author), US Mil Acad, Dept Geog & Environm Engn, 745 Brewerton Rd,Rm 6004, West Point, NY 10996 USA. EM Dylan.malcomb@usma.edu; Elizabeth.weaver@usma.edu; Amy.krakowka@usma.edu OI Richmond, Amy/0000-0002-9045-537X NR 49 TC 7 Z9 7 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-6228 EI 1873-7730 J9 APPL GEOGR JI Appl. Geogr. PD MAR PY 2014 VL 48 BP 17 EP 30 DI 10.1016/j.apgeog.2014.01.004 PG 14 WC Geography SC Geography GA AE5BX UT WOS:000334003900003 ER PT J AU Kunz, M Buchanan, MF Randall, JL Wall, WA Hohmann, MG AF Kunz, Michael Buchanan, Misty F. Randall, John L. Wall, Wade A. Hohmann, Matthew G. TI Life Cycle, Vegetative Propagation, and Reintroduction of Federally Endangered Rough-Leaved Loosestrife, Lysimachia asperulifolia SO CASTANEA LA English DT Article DE Endangered species; Lysimachia; pseudoannual; reintroduction; vegetative reproduction ID CLONAL PLANTS; CONSEQUENCES; PLASTICITY; GROWTH AB The ability to propagate and successfully reintroduce rare plant species is an important component in the conservation biologist's toolbox. Unfortunately for many species, propagation methods and details about the species' life histories, which can potentially inform reintroduction efforts, are often unknown. We describe for the first time the pseudoannual life cycle of rough-leaved loosestrife (Lysimachia asperulifolia Poiret [Primulaceae]) and techniques that we have used to vegetatively propagate and reintroduce this federally endangered species endemic to the Atlantic Coastal Plain of the United States. Using simulated dormancy and controlled soil temperatures, we increased the number of collected viable rhizomes by approximately 76% over one growing season. At two translocation sites, stem numbers increased an average of 318 +/- 145 SD % in five of seven test plots between 2004 and 2010. Using dormant-season-harvested rhizomes and/or reducing competition prior to transplanting via mowing or using herbicides greatly improved translocation success. Only plots receiving neither competition-reduction treatment and outplanted with summer harvested rhizomes showed reductions (73 +/- 21 SD %) in the number of stems. Although limited flowering and no capsule production was detected at the translocation sites, a similar lack of sexual reproduction is common in many natural populations of L. asperulifolia. Overall, our results will allow the United States Fish and Wildlife Service and their conservation partners to more confidently pursue recovery goals for the species. C1 [Kunz, Michael; Randall, John L.] Univ N Carolina, North Carolina Bot Garden, Chapel Hill, NC 27599 USA. [Buchanan, Misty F.] North Carolina Nat Heritage Program, Mail Serv Ctr 1601, Raleigh, NC 27699 USA. [Wall, Wade A.; Hohmann, Matthew G.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Kunz, M (reprint author), Univ N Carolina, North Carolina Bot Garden, CB 3375, Chapel Hill, NC 27599 USA. EM mkunz@email.unc.edu FU North Carolina Department of Transportation; Department of Defense, Environmental Security Technology Certification Program FX We thank Mary Frazer (North Carolina Department of Transportation), Matt Gocke (North Carolina Botanical Garden), North Carolina Botanical Garden staff and volunteers, Janet Gray (Fort Bragg), Ken Shughart (North Carolina Wildlife Resource Commission), Dale Suiter (US Fish and Wildlife Service), and Brent Wilson (North Carolina Wildlife Resource Commission). Funding for this project was provided by North Carolina Department of Transportation and the Department of Defense, Environmental Security Technology Certification Program. NR 28 TC 3 Z9 3 U1 4 U2 12 PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL PI NEWBERRY PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST, NEWBERRY, SC 29108 USA SN 0008-7475 EI 1938-4386 J9 CASTANEA JI Castanea PD MAR PY 2014 VL 79 IS 1 BP 18 EP 26 DI 10.2179/13-007 PG 9 WC Plant Sciences SC Plant Sciences GA AF8OS UT WOS:000334976100003 ER PT J AU Rasmussen, TE Baer, DG AF Rasmussen, Todd E. Baer, David G. TI No Drift SO JAMA SURGERY LA English DT Editorial Material ID EVENTS C1 [Rasmussen, Todd E.; Baer, David G.] US Army, Inst Surg Res, San Antonio, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 8 TC 4 Z9 4 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD MAR PY 2014 VL 149 IS 3 BP 221 EP 222 DI 10.1001/jamasurg.2013.3206 PG 2 WC Surgery SC Surgery GA AF3JX UT WOS:000334609400001 PM 24382625 ER PT J AU McCall, JR Jacocks, HM Niven, SC Poli, MA Baden, DG Bourdelais, AJ AF McCall, Jennifer R. Jacocks, Henry M. Niven, Susan C. Poli, Mark A. Baden, Daniel G. Bourdelais, Andrea J. TI Development and Utilization of a Fluorescence-Based Receptor-Binding Assay for the Site 5 Voltage-Sensitive Sodium Channel Ligands Brevetoxin and Ciguatoxin SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID DINOFLAGELLATE KARENIA-BREVIS; RAT-BRAIN; RED TIDES; CIGUATERA; ACTIVATORS; DISCOVERY; BARRACUDA; SHELLFISH; NEURONS; ASTHMA AB Brevetoxins are a family of ladder-frame polyether toxins produced during blooms of the marine dinoflagellate Karenia brevis. Consumption of fish exposed to K. brevis blooms can lead to the development of neurotoxic shellfish poisoning. The toxic effects of brevetoxins are due to activation of voltage-sensitive sodium channels (VSSCs) in cell membranes. Binding of toxins has historically been measured using a radioligand competition assay that is fraught with difficulty. In this study, we developed a novel fluorescence-based binding assay for the brevetoxin receptor. Several fluorophores were conjugated to polyether brevetoxin-2 and used as the labeled ligand. Brevetoxin analogs were able to compete for binding with the fluorescent ligands. This assay was qualified against the standard radioligand receptor assay for the brevetoxin receptor. Furthermore, the fluorescence-based assay was used to determine relative concentrations of toxins in raw extracts of K. brevis culture, and to determine ciguatoxin affinity to site 5 of VSSCs. The fluorescence-based assay was quicker, safer, and far less expensive. As such, this assay can be used to replace the current radioligand assay and will be a vital tool for future experiments examining the binding affinity of various ligands for site 5 on sodium channels. C1 [McCall, Jennifer R.; Jacocks, Henry M.; Niven, Susan C.; Baden, Daniel G.; Bourdelais, Andrea J.] Univ N Carolina, Ctr Marine Sci, Wilmington, NC 28409 USA. [Poli, Mark A.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP McCall, JR (reprint author), Univ N Carolina, Ctr Marine Sci, 5600 Marvin K Moss Ln, Wilmington, NC 28409 USA. EM mccalljr@uncw.edu FU National Institutes of Health [PO1 ES10594-10, R21 NS067503-A101]; National Oceanic and Atmospheric Administration Cooperative Institute for Ocean Exploration, Research and Technology [NA09OAR4320073]; National Science Foundation [IOS-1154734]; Marine Biology in North Carolina (MARBIONC), an economic development program FX This work was supported by National Institutes of Health grants PO1 ES10594-10 and R21 NS067503-A101, National Oceanic and Atmospheric Administration Cooperative Institute for Ocean Exploration, Research and Technology grant NA09OAR4320073, and National Science Foundation grant IOS-1154734. Portions of this work were sponsored. by Marine Biology in North Carolina (MARBIONC), an economic development program located at University of North Carolina Wilmington. NR 42 TC 4 Z9 4 U1 1 U2 20 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD MAR-APR PY 2014 VL 97 IS 2 BP 307 EP 315 DI 10.5740/jaoacint.SGEMcCa1l PG 9 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA AF2UP UT WOS:000334568300005 PM 24830141 ER PT J AU Grussing, MN AF Grussing, Michael N. TI Life Cycle Asset Management Methodologies for Buildings SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Condition assessment; Buildings; Asset management; Facility life cycle; Infrastructure AB Although asset management methodologies and tools related to the civil infrastructure domain have existed for decades, there are many challenges in applying these same techniques to buildings. This is because of the complexity and diversity of building structures, and their ownership profile. Numerous influences including scarcity of energy and material resources and land are creating greater awareness of the need for structured building management to reduce total life cycle needs. This reduction in consumption needs to be balanced with the requirements of the building occupant, such that building services are provided at a certain level of quality over a specified lifespan. Whether the building reaches that life and how it performs in service depends on maintenance, repair, and modernization during that timeframe, or restoration and recapitalization near the end of that timeframe. Optimal facility asset management needs to consider minimizing the life cycle costs related to these activities, while ensuring building performance levels related to condition, serviceability, safety, and capacity are met. Any decision framework should attempt to identify operational, tactical, and strategic consequences and outcomes to maximize the benefit of an investment in building facilities. The objectives of this paper are to identify the wide array of approaches to building life cycle management, review the benefits and challenges of the current state of practice, and propose a framework for achieving improved facility information for actionable facility decision support. An example case study is also provided. C1 US Army Corps Engineers, Ctr Res & Dev, Champaign, IL 61822 USA. RP Grussing, MN (reprint author), US Army Corps Engineers, Ctr Res & Dev, 2902 Newmark Dr, Champaign, IL 61822 USA. EM michael.n.grussing@usace.army.mil NR 36 TC 0 Z9 0 U1 1 U2 18 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD MAR 1 PY 2014 VL 20 IS 1 DI 10.1061/(ASCE)IS.1943-555X.0000157 PG 8 WC Engineering, Civil SC Engineering GA AF4GJ UT WOS:000334669600007 ER PT J AU Kalantarnia, M Chouinard, L Foltz, S AF Kalantarnia, Maryam Chouinard, Luc Foltz, Stuart TI Application of Dormant Reliability Analysis to Spillways SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Reliability; Availability; Condition assessment; Gate; Spillway; Component integrity AB Dams are essential infrastructures for water supply, flood control, energy production, and irrigation. A critical component for the safety of a dam is the spillway system which, by controlling releases, prevents overtopping of the dam. This in turn reduces impacts associated with excessive downstream flows and upstream water levels on infrastructures, the population, and the environment. This paper addresses reliability issues related to emergency spillways and specifically the estimation of their reliability level after prolonged periods of dormancy. During dormancy, spillway components are exposed to the environment and sustain cumulative damage that may trigger latent failures or failures on demand. Regular inspections and tests are used to detect and remediate latent failures and to assess the level of deterioration of components. The purpose of this study is to develop procedures to account for dormancy in the reliability analysis of spillways. It also demonstrates how these procedures can be used to evaluate the impact of the frequency of inspections and tests on the overall reliability of the spillways. This paper introduces measure of performance, dormant availability analysis, and dormant availability analysis via integrity assessment as methods to illustrate the unavailability or probability of failure on demand of a spillway system as a function of its dormancy period. This information can be used to determine the optimum frequency of inspection and tests taking into account the safety of the structure as well as the costs associated with inspection and testing. C1 [Kalantarnia, Maryam; Chouinard, Luc] McGill Univ, Dept Civil Engn & Appl Mech, Montreal, PQ H3A 2K6, Canada. [Foltz, Stuart] US Army Construct Engn Res Lab, Champaign, IL 61822 USA. RP Kalantarnia, M (reprint author), McGill Univ, Dept Civil Engn & Appl Mech, Montreal, PQ H3A 2K6, Canada. EM maryam.kalantarnia@mail.mcgill.ca FU Discovery Grant from the National Research Council of Canada FX This research was funded from a Discovery Grant from the National Research Council of Canada and through contributions from the USACE-CERL and Hydro-Quebec. The authors would also like to acknowledge the constructive comments from the reviewers. NR 18 TC 1 Z9 1 U1 1 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD MAR 1 PY 2014 VL 20 IS 1 DI 10.1061/(ASCE)IS.1943-555X.0000159 PG 7 WC Engineering, Civil SC Engineering GA AF4GJ UT WOS:000334669600002 ER PT J AU Walker, RS Pettitt, JA Scruggs, KT Mlakar, PF AF Walker, Robert S. Pettitt, James A. Scruggs, Kevin T. Mlakar, Paul F. TI Data Collection and Organization by Smartphone for Infrastructure Assessment SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Information management; Data collection; Infrastructure; Assessment AB The collection and organization of data for infrastructure assessment have traditionally been laborious and lengthy tasks. Smartphones now provide the needed hardware and software to ease the burden of these chores. The authors have developed the Mobile Information Collection Application, which organizes these capabilities for infrastructure assessment. The use of this application in the 2011 Mississippi River flood of record and in the reconnaissance of routes for movement indicates that it can improve the effectiveness and efficiency of information collection and organization. C1 [Walker, Robert S.; Pettitt, James A.; Mlakar, Paul F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Scruggs, Kevin T.] US Mil Acad, West Point, NY 10996 USA. RP Mlakar, PF (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Paul.F.Mlakar@usace.army.mil NR 7 TC 2 Z9 2 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD MAR 1 PY 2014 VL 20 IS 1 DI 10.1061/(ASCE)IS.1943-555X.0000166 PG 4 WC Engineering, Civil SC Engineering GA AF4GJ UT WOS:000334669600004 ER PT J AU Abadie, JM Lambert, HB AF Abadie, Jude M. Lambert, Hovey B. TI Effects of Lubricants and Wash Solutions on Semen Evaluation in a Fertility Clinic Laboratory SO LABMEDICINE LA English DT Article DE semen analysis; macroscopic and microscopic evaluation; infertility AB Objective: The complex nature of semen components and the various collection procedures make standardization of semen analysis (SA) challenging. Therefore, the main goal of this study was to optimize and improve the quality and utility of the SA report. Methods: Semen samples (n=20) were split into 2 aliquots to compare 2 isolation gradients. Samples incubated in the different wash medium were evaluated for motility, forward progression, morphology, and suitability for intrauterine insemination (IUI). Another group (n=20) was evaluated for IUI utility without and with a lubricant to compare motility and sperm count. Results: There were no significant differences in motility, forward progression, or morphology with or without a lubricant. With respect to gradient types, Pure Sperm 40/80 isolated significantly higher yields of motile sperm than the isolate. In comparing wash media, at 2 hours Pure Sperm was significantly higher in both motility and count compared to Irvine culture media. Conclusion: This study represents a significant advance toward improved applications and methods for SA testing. Continued standardization and improvements in SA will require additional evaluation of lab testing methods. C1 [Abadie, Jude M.; Lambert, Hovey B.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Abadie, JM (reprint author), Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. EM jude.m.abadie.mil@mai.mil NR 6 TC 0 Z9 1 U1 0 U2 2 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 EI 1943-7730 J9 LABMEDICINE JI Labmedicine PD SPR PY 2014 VL 45 IS 2 BP 116 EP 119 DI 10.1309/LM0RXLDULFIF9TQ6 PG 4 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AF2RR UT WOS:000334560200004 PM 24868991 ER PT J AU Velasco, JMS Alera, MTP Ypil-Cardenas, CA Dimaano, EM Jarman, RG Chinnawirotpisan, P Thaisomboonsuk, B Yoon, IK Cummings, DA Mammen, MP AF Velasco, John Mark S. Alera, Ma Theresa P. Ypil-Cardenas, Charity Ann Dimaano, Efren M. Jarman, Richard G. Chinnawirotpisan, Piyawan Thaisomboonsuk, Butsaya Yoon, In-Kyu Cummings, Derek A. Mammen, Mammen P., Jr. TI DEMOGRAPHIC, CLINICAL AND LABORATORY FINDINGS AMONG ADULT AND PEDIATRIC PATIENTS HOSPITALIZED WITH DENGUE IN THE PHILIPPINES SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE dengue infection; adult; pediatric patient; serotype; signs; symptoms; lab results; Philippines ID HEMORRHAGIC-FEVER; THAILAND; INFECTIONS; FEATURES; CHILDREN; EPIDEMIOLOGY; OUTBREAK; BLOOD AB We evaluated the differences in demographic, clinical, and laboratory findings between adult and pediatric patients hospitalized with dengue fever. Ninety patients with dengue infection admitted at San Lazaro Hospital (SLH), Manila from September 2005 to January 2006 were included in the study. The cases were laboratory-confirmed to have dengue infection. The majority of dengue cases (92%) had secondary dengue infection (median age=18, age range: 2-37) while the remainder (8%) had a primary dengue infection (median age=12, age range: 7-22). Nearly all the patients (99%) had dengue hemorrhagic fever (DHF). Sixty-five of the cases (72%) had serotype data: 2 (3%) were dengue virus serotype 1 (DENV-1) (median age=17), 12 (18%) had DENV-2 (median age=17.5), 38 (59%) had DENV-3 (median age=16) and 13 (20%) had DENV-4 (median age=18). The initial signs, symptoms and laboratory results except hematocrit (p =0.02) and hemoglobin (p =0.02) did not differ significantly between adults and children. During the study period, half the cases were adults (>= 18 years; n=45) and half were children (<18 years; n=45). The ages of cases ranged from 2 to 37 years (median=17 years) and the peak incidence was 15-19 years. Dengue is often considered as a pediatric disease. Additional studies are needed to determine if an age shift is occurring and where. C1 [Velasco, John Mark S.; Ypil-Cardenas, Charity Ann; Jarman, Richard G.; Chinnawirotpisan, Piyawan; Thaisomboonsuk, Butsaya; Yoon, In-Kyu; Mammen, Mammen P., Jr.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Alera, Ma Theresa P.; Dimaano, Efren M.] San Lazaro Hosp, Manila, Philippines. [Cummings, Derek A.] Sch Publ Hlth, Baltimore, MD USA. RP Velasco, JMS (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM VelascoJM@afrims.org FU US Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System (AFHSC-GEIS); Burroughs Welcome Fund; Bill and Melinda Gates Foundations Vaccine Modeling Initiative FX The authors wish to thank Dr Lyndon Lee Suy (Department of Health), Dr Raman Velayudhan (World Health Organization), and the clinical and laboratory staff of SLH, specifically Dr Edna Edrada and Dr Edna Miranda for their help in data collection, Dr Dorothy Agdamag and Ms Adelfa Espantaleon of SACCL for specimen testing, Ms Panor Srisongkram and Ms Thidarat Intararit of AFRIMS for coordinating study-related activites, and Ms Chie Delino and Dr Mark Angelo Ang for statistical analysis. This study was funded by the US Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System (AFHSC-GEIS). DATC holds a Career Award at the Scientific Interface from the Burroughs Welcome Fund. DATC also received funding from the Bill and Melinda Gates Foundations Vaccine Modeling Initiative. NR 37 TC 4 Z9 5 U1 0 U2 4 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAR PY 2014 VL 45 IS 2 BP 337 EP 345 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA AF5BM UT WOS:000334729000010 PM 24968673 ER PT J AU Stannard, A Morrison, J Midwinter, M Rasmussen, T Tai, N AF Stannard, A. Morrison, J. Midwinter, M. Rasmussen, T. Tai, N. TI Evolution in vascular trauma management through 12 years of continuous conflict SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT 48th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland CY NOV 27-29, 2013 CL Manchester, ENGLAND SP Vasc Soc Great Britain & Ireland C1 [Stannard, A.; Morrison, J.; Midwinter, M.; Tai, N.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, T.] US Army Inst Surg Res, San Antonio, TX USA. RI Midwinter, Mark/P-6264-2015 OI Midwinter, Mark/0000-0003-1836-7137 NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD MAR PY 2014 VL 101 SU 2 SI SI BP 3 EP 3 PG 1 WC Surgery SC Surgery GA AC7EI UT WOS:000332689600010 ER PT J AU Langer, T Vecchi, V Belenkiy, SM Cannon, JW Chung, KK Cancio, LC Gattinoni, L Batchinsky, AI AF Langer, Thomas Vecchi, Vittoria Belenkiy, Slava M. Cannon, Jeremy W. Chung, Kevin K. Cancio, Leopoldo C. Gattinoni, Luciano Batchinsky, Andriy I. TI Extracorporeal Gas Exchange and Spontaneous Breathing for the Treatment of Acute Respiratory Distress Syndrome: An Alternative to Mechanical Ventilation? SO CRITICAL CARE MEDICINE LA English DT Letter DE acute respiratory distress syndrome; control of breathing; extracorporeal membrane oxygenation; healthy lungs; spontaneous breathing; transpulmonary pressure ID ACUTE LUNG INJURY; CARBON-DIOXIDE REMOVAL; 2009 INFLUENZA A(H1N1); MEMBRANE-OXYGENATION; OLEIC-ACID; ACTIVE REHABILITATION; PULMONARY; TRANSPLANTATION; BRIDGE; PRESSURE AB Objectives: Venovenous extracorporeal gas exchange is increasingly used in awake, spontaneously breathing patients as a bridge to lung transplantation. Limited data are available on a similar use of extracorporeal gas exchange in patients with acute respiratory distress syndrome. The aim of this study was to investigate the use of extracorporeal gas exchange in awake, spontaneously breathing sheep with healthy lungs and with acute respiratory distress syndrome and describe the interactions between the native lung (healthy and diseased) and the artificial lung (extracorporeal gas exchange) in this setting. Design: Laboratory investigation. Setting: Animal ICU of a governmental laboratory. Subjects: Eleven awake, spontaneously breathing sheep on extracorporeal gas exchange. Interventions: Sheep were studied before (healthy lungs) and after the induction of acute respiratory distress syndrome via IV injection of oleic acid. Six gas flow settings (1-10 L/min), resulting in different amounts of extracorporeal Co-2 removal (20-100% of total Co-2 production), were tested in each animal before and after the injury. Measurements and Main Results: Respiratory variables and gas exchange were measured for every gas flow setting. Both healthy and injured sheep reduced minute ventilation according to the amount of extracorporeal Co-2 removal, up to complete apnea. However, compared with healthy sheep, sheep with acute respiratory distress syndrome presented significantly increased esophageal pressure variations (25 9 vs 6 +/- 3 cm H2O; p < 0.001), which could be reduced only with very high amounts of Co-2 removal (> 80% of total Co-2 production). Conclusions: Spontaneous ventilation of both healthy sheep and sheep with acute respiratory distress syndrome can be controlled via extracorporeal gas exchange. If this holds true in humans, extracorporeal gas exchange could be used in awake, spontaneously breathing patients with acute respiratory distress syndrome to support gas exchange. A deeper understanding of the pathophysiology of spontaneous breathing during acute respiratory distress syndrome is however warranted in order to be able to propose extracorporeal gas exchange as a safe and valuable alternative to mechanical ventilation for the treatment of patients with acute respiratory distress syndrome. C1 [Langer, Thomas; Vecchi, Vittoria; Belenkiy, Slava M.; Cannon, Jeremy W.; Chung, Kevin K.; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army Inst Surg Res, Comprehens Intens Care Res Task Area, San Antonio, TX USA. [Langer, Thomas; Gattinoni, Luciano] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, Italy. [Langer, Thomas; Vecchi, Vittoria] Natl Acad, Natl Res Council, Washington, DC USA. [Vecchi, Vittoria] Univ Milan, Sch Med, I-20122 Milan, Italy. [Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Gattinoni, Luciano] Fdn IRCCS Ca Granda Osped Maggiore Policlin Milan, Dipartimento Anestesia Rianimaz Intens & Sub Inte, Milan, Italy. RP Langer, T (reprint author), Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Via F Sforza 35, I-20122 Milan, Italy. EM thomas.langer@unimi.it NR 48 TC 18 Z9 19 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD MAR PY 2014 VL 42 IS 3 BP E211 EP E220 DI 10.1097/CCM.0000000000000121 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA AA9AX UT WOS:000331387200004 PM 24361970 ER PT J AU Pullmann, LD Johnson, PL Faran, ME AF Pullmann, Lynette Dufton Johnson, Patti L. Faran, Michael E. TI Implementing an Evidence-Based Practices Training Curriculum to U.S. Army Child and Family Behavioral Health Providers SO JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY LA English DT Article ID MILITARY FAMILIES; PATIENT PROGRESS; COMMON ELEMENTS; DEPLOYMENT; OUTCOMES; PSYCHOTHERAPY; THERAPISTS; KNOWLEDGE; ATTITUDES; YOUTH AB Military Children who have experienced multiple deployments of one or both parents are more likely to have emotional and behavioral difficulties compared with their civilian peers (e.g., Chandra et al., 2010). The U.S. Army Medical Command has tasked the Child, Adolescent and Family Behavioral Health Office (CAF-BHO) to develop programs to address the behavioral health (BH) needs of Army Children and Families. This article will describe the efforts of the CAF-BHO Training Section to disseminate and implement an evidence based practice training curriculum for Army Child and Family Behavioral Health Providers. Specifically, this article will detail: (a) the decision making strategy used to identify the training protocol for dissemination, (b) adaptations to the training program and treatment protocol to fit a Military context, and (c) efforts to implement, maximize and sustain utilization of evidence-based practices by Military BH providers over a large geographical area with limited resources. C1 [Pullmann, Lynette Dufton; Johnson, Patti L.; Faran, Michael E.] US Army Med Command, Child Adolescent & Family Behav Hlth Off, Tacoma, WA 98431 USA. RP Pullmann, LD (reprint author), US Army Med Command, Child Adolescent & Family Behav Hlth Off, Bldg 9913A MAMC Annex, Tacoma, WA 98431 USA. EM lynettedufton@gmail.com NR 55 TC 1 Z9 1 U1 1 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1537-4416 EI 1537-4424 J9 J CLIN CHILD ADOLESC JI J. Clin. Child Adolesc. Psychol. PD MAR 1 PY 2014 VL 43 IS 2 SI SI BP 158 EP 168 DI 10.1080/15374416.2013.833096 PG 11 WC Psychology, Clinical; Psychology, Developmental SC Psychology GA AE4XW UT WOS:000333991700003 PM 24063249 ER PT J AU Sharlow, ER Leimgruber, S Murray, S Lira, A Sciotti, RJ Hickman, M Hudson, T Leed, S Caridha, D Barrios, AM Close, D Grogl, M Lazo, JS AF Sharlow, Elizabeth R. Leimgruber, Stephanie Murray, Samantha Lira, Ana Sciotti, Richard J. Hickman, Mark Hudson, Thomas Leed, Susan Caridha, Diana Barrios, Amy M. Close, David Groegl, Max Lazo, John S. TI Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity SO ACS CHEMICAL BIOLOGY LA English DT Article ID LEISHMANIA-DONOVANI PROMASTIGOTES; PROGRAMMED CELL-DEATH; CUTANEOUS LEISHMANIASIS; HIGH-THROUGHPUT; MILTEFOSINE; DISEASE; PHARMACOLOGY; ACQUISITION; VALIDATION; RESISTANCE AB Cutaneous leishmaniasis remains ignored in therapeutic drug discovery programs worldwide. This is mainly because cutaneous leishmaniasis is frequently a disease of impoverished populations in countries where funds are limited for research and patient care. However, the health burden of individuals in endemic areas mandates readily available, effective, and safe treatments. Of the existing cutaneous leishmaniasis therapeutics, many are growth inhibitory to Leishmania parasites, potentially creating dormant parasite reservoirs that can be activated when host immunity is compromised, enabling the reemergence of cutaneous leishmaniasis lesions or worse spread of Leishmania parasites to other body sites. To accelerate the identification and development of novel cutaneous leishmaniasis therapeutics, we designed an integrated in vitro and in vivo screening platform that incorporated multiple Leishmania life cycles and species and probed a focused library of pharmaceutically active compounds. The objective of this phenotypic drug discovery platform was the identification and prioritization of bona fide cytotoxic chemotypes toward Leishmania parasites. We identified the Food and Drug Administration-approved drug auranofin, a known inhibitor of Leishmania promastigote growth, as a potent cytotoxic anti-leishmanial agent and inducer of apoptotic-like death in promastigotes. Significantly, the anti-leishmanial activity of auranofin transferred to cell-based amastigote assays as well as in vivo murine models. With appropriate future investigation, these data may provide the foundation for potential exploitation of gold(I)-based complexes as chemical tools or the basis of therapeutics for leishmaniasis. Thus, auranofin may represent a prototype drug that can be used to identify signaling pathways within the parasite and host cell critical for parasite growth and survival. C1 [Sharlow, Elizabeth R.; Leimgruber, Stephanie; Murray, Samantha; Lira, Ana; Lazo, John S.] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA. [Lazo, John S.] Univ Virginia, Dept Chem, Charlottesville, VA 22908 USA. [Sciotti, Richard J.; Hickman, Mark; Hudson, Thomas; Leed, Susan; Caridha, Diana; Groegl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Discovery, Silver Spring, MD 20910 USA. [Barrios, Amy M.] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA. [Close, David] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15260 USA. RP Sharlow, ER (reprint author), Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA. EM ers7g@virginia.edu FU Fiske Drug Discovery Laboratory, Department of Defense [W81WH-10-2-001]; U.S. Military Infectious Disease Research Program FX We thank R. Pearson, J.C. Morris, J. Aube, and J. Golden for manuscript review. J. Ahn's and Stacey Guillot's assistance with library reformatting and scanning electron microscopy in the University of Virginia Advanced Microscopy Facility, respectively, is appreciated. Research was supported by the Fiske Drug Discovery Laboratory, Department of Defense grant W81WH-10-2-001 (E.R.S./J.S.L.) and the U.S. Military Infectious Disease Research Program. Opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of the Army or Department of Defense. NR 36 TC 12 Z9 12 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1554-8929 EI 1554-8937 J9 ACS CHEM BIOL JI ACS Chem. Biol. PD MAR PY 2014 VL 9 IS 3 BP 663 EP 672 DI 10.1021/cb400800q PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AD7WI UT WOS:000333477300013 PM 24328400 ER PT J AU Page, A Volchkova, VA Reid, S Mateo, M Bagnaud-Baule, A Nemirov, K Shurtleff, AC Lawrence, P Reynard, O Ottmann, M Lotteau, V Biswal, SS Thimmulappa, RK Bavari, S Volchkov, VE AF Page, Audrey Volchkova, Valentina A. Reid, St Patrick Mateo, Mathieu Bagnaud-Baule, Audrey Nemirov, Kirill Shurtleff, Amy C. Lawrence, Philip Reynard, Oliver Ottmann, Michele Lotteau, Vincent Biswal, Shyam S. Thimmulappa, Rajesh K. Bavari, Sina Volchkov, Viktor E. TI Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1 SO CELL REPORTS LA English DT Article ID TRANSCRIPTION FACTOR NRF2; EBOLA HEMORRHAGIC-FEVER; HEPATITIS-C VIRUS; OXIDATIVE STRESS; INFLAMMATORY RESPONSES; GENE-EXPRESSION; KELCH DOMAIN; DLG MOTIFS; E3 LIGASE; ACTIVATION AB Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation. Here, we demonstrate that VP24 of MARV binds Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear transcription factor erythroid-derived 2 (Nrf2). Binding of VP24 to Keap1 Kelch domain releases Nrf2 from Keap1-mediated inhibition promoting persistent activation of a panoply of cytoprotective genes implicated in cellular responses to oxidative stress and regulation of inflammatory responses. Increased expression of Nrf2-dependent genes was demonstrated both during MARV infection and upon ectopic expression of MARV VP24. We also show that Nrf2-deficient mice can control MARV infection when compared to lethal infection in wild-type animals, indicating that Nrf2 is critical for MARV infection. We conclude that VP24-driven activation of the Nrf2-dependent pathway is likely to contribute to dysregulation of host antiviral inflammatory responses and that it ensures survival of MARV-infected cells despite these responses. C1 [Page, Audrey; Volchkova, Valentina A.; Reid, St Patrick; Mateo, Mathieu; Bagnaud-Baule, Audrey; Nemirov, Kirill; Lawrence, Philip; Reynard, Oliver; Ottmann, Michele; Volchkov, Viktor E.] Univ Lyon 1, Ecole Normale Super Lyon, INSERMU1111, CIRI,CNRSUMR5308, F-69007 Lyon, France. [Reid, St Patrick; Shurtleff, Amy C.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Lotteau, Vincent] CIRI, IMAP team, F-69007 Lyon, France. [Biswal, Shyam S.; Thimmulappa, Rajesh K.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA. RP Volchkov, VE (reprint author), Univ Lyon 1, Ecole Normale Super Lyon, INSERMU1111, CIRI,CNRSUMR5308, F-69007 Lyon, France. EM viktor.volchkov@inserm.fr RI Volchkov, Viktor/M-7846-2014; Lawrence, Philip/M-7897-2014; reynard, olivier/M-8069-2014; lotteau, vincent/M-8143-2014 OI Volchkov, Viktor/0000-0001-7896-8706; FU European Union FP7 project ANTIGONE [278976]; Agence Nationale de la Recherche [ANR-07-MIME-006-01]; Fondation pour la Recherche Medicale [DMI20091117323] FX We are grateful to A. I. Cederbaum (Mount Sinai School of Medicine, New York) for the pHCMV-Nrf2 and pHHO1-Luc reporter system and to M. Yamamoto for pmNQO1-ARE-Luc. We thank L. Tafforeau, M. Lebreton, and T. Chantier for technical help with double-hybrid screening and S. Naik for reading the manuscript. We would like to acknowledge the Biosafety team members of the Jean Merieux BSL4 facility. This work was supported by the European Union FP7 project ANTIGONE (278976), Agence Nationale de la Recherche (ANR-07-MIME-006-01), and Fondation pour la Recherche Medicale (DMI20091117323). NR 53 TC 17 Z9 17 U1 1 U2 9 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD MAR PY 2014 VL 6 IS 6 BP 1026 EP 1036 DI 10.1016/j.celrep.2014.02.027 PG 11 WC Cell Biology SC Cell Biology GA AD7SD UT WOS:000333465000008 PM 24630992 ER PT J AU Via, SM Zinnert, JC Butler, AD Young, DR AF Via, Stephen M. Zinnert, Julie C. Butler, Afrachanna D. Young, Donald R. TI Comparative physiological responses of Morella cerifera to RDX, TNT, and composition B contaminated soils SO ENVIRONMENTAL AND EXPERIMENTAL BOTANY LA English DT Article DE Explosives; TNT; RDX; Composition B; Plant physiology; Soil contamination ID WATER-STRESS; SEEDLING DEVELOPMENT; SMOOTH BROMEGRASS; REMOTE DETECTION; TALL FESCUE; PLANTS; GROWTH; FATE; 2,4,6-TRINITROTOLUENE; EXPOSURE AB Surrounding vegetation is exposed to a variety of potentially toxic compound S due to unexploded ordnances leaching explosive compounds into the soil. These compounds are absorbed by roots, transported through the vascular system, and distributed throughout plant tissues. Research Demolition Explosive (RDX) (hexahydro-1,3,5-trinitro-1,3,5-triazine) and trinitrotoluene (TNT) (2-methyl-1,3,5-trinitrobenzene) are the most studied; however, mixtures of explosives are widespread in conventional munitions. Composition B (Comp B), a mixture of RDX and TNT, is the most common mixture. Our study objective was to quantify the comparative effects of RDX, TNT and Comp B on the physiology of an evergreen shrub, Morella cerifera. Adult M. cerifera plants were exposed for 7 weeks to soil amended with RDX up to 1500 mg kg(-1) dry soil, TNT up to 500 mg kg(-1) dry soil, and Comp B up to 750 mg kg(-1) dry soil. Stomatal conductance, photosynthesis, leaf water potential, leaf fluorescence, and contaminant uptake values were measured at the end of the experiment. As contaminant concentration increased, significant declines in photosynthesis and leaf fluorescence occurred for all compounds. Overall responses varied between contaminants and impacts of Comp B were largely reduced compared to either RDX or TNT. Of all physiological parameters, photosynthesis was most impacted, making it a sensitive indicator for the detection of explosives. Yet, the intricate relationships within normal physiological processes appear to be severed in the presence of explosives. These disparate responses in plant physiology may serve as a method for explosive contamination stress detection. Our results highlight the importance of studying real world munition mixtures. (C) 2013 Elsevier B.V. All rights reserved. C1 [Via, Stephen M.; Zinnert, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Zinnert, Julie C.] US Army Engineer Res & Dev Ctr, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Butler, Afrachanna D.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Zinnert, JC (reprint author), Virginia Commonwealth Univ, 1000 West Cary St, Richmond, VA 23284 USA. EM jczinnert@vcu.edu OI Via, Stephen/0000-0002-4640-1673; Via, Stephen/0000-0002-6756-4156 FU U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC); United States Army Research Office [W911NF-10-1-0433] FX This research was supported by internal basic research program funds from the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) and a grant (W911NF-10-1-0433) from the United States Army Research Office. The authors thank Spencer Bissett, Paul Manley, and Ed Crawford for support with plant retrieval and maintenance. NR 51 TC 6 Z9 6 U1 0 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0098-8472 EI 1873-7307 J9 ENVIRON EXP BOT JI Environ. Exp. Bot. PD MAR PY 2014 VL 99 BP 67 EP 74 DI 10.1016/j.envexpbot.2013.11.002 PG 8 WC Plant Sciences; Environmental Sciences SC Plant Sciences; Environmental Sciences & Ecology GA AD8JZ UT WOS:000333513600009 ER PT J AU Liu, RF Wallqvist, A AF Liu, Ruifeng Wallqvist, Anders TI Merging Applicability Domains for in Silico Assessment of Chemical Mutagenicity SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID DESCRIPTORS; SIMILARITY; QSAR; FINGERPRINTS; GENOTOXICITY; PREDICTION; QSPR; SET AB Using a benchmark Ames mutagenicity data set, we evaluated the performance of molecular fingerprints as descriptors for developing quantitative structure activity relationship (QSAR) models and defining applicability domains with two machine-learning methods: random forest (RF) and variable nearest neighbor (v-NN). The two methods focus on complementary aspects of chemical mutagenicity and use different characteristics of the molecular fingerprints to achieve high levels of prediction accuracies. Thus, while RF flags mutagenic compounds using the presence or absence of small molecular fragments akin to structural alerts, the v-NN method uses molecular structural similarity as measured by fingerprint-based Tanimoto distances between molecules. We showed that the extended connectivity fingerprints could intuitively be used to define and quantify an applicability domain for either method. The importance of using applicability domains in QSAR modeling cannot be understated; compounds that are outside the applicability domain do not have any close representative in the training set, and therefore, we cannot make reliable predictions. Using either approach, we developed highly robust models that rival the performance of a state-of-the-art proprietary software package. Importantly, based on the complementary approach used by the methods, we showed that by combining the model predictions we raised the applicability domain from roughly 80% to 90%. These results indicated that the proposed QSAR protocol constituted a highly robust chemical mutagenicity prediction model. C1 [Liu, Ruifeng; Wallqvist, Anders] US Army Med Res & Materiel Command, DoD, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Frederick, MD 21702 USA. RP Liu, RF (reprint author), US Army Med Res & Materiel Command, DoD, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, 2405 Whittier Dr, Frederick, MD 21702 USA. EM RLiu@bhsai.org; AWallqvist@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network Science Initiative; Defense Threat Reduction Agency [CBCall14-CBS-05-2-0007] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network Science Initiative, and the Defense Threat Reduction Agency grant CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 26 TC 9 Z9 9 U1 1 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 EI 1549-960X J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD MAR PY 2014 VL 54 IS 3 BP 793 EP 800 DI 10.1021/ci500016v PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA AD7WS UT WOS:000333478800010 PM 24494696 ER PT J AU Henning, PC Scofield, DE Spiering, BA Staab, JS Matheny, RW Smith, MA Bhasin, S Nindl, BC AF Henning, Paul C. Scofield, Dennis E. Spiering, Barry A. Staab, Jeffery S. Matheny, Ronald W., Jr. Smith, Martha A. Bhasin, Shalender Nindl, Bradley C. TI Recovery of Endocrine and Inflammatory Mediators Following an Extended Energy Deficit SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID GROWTH-FACTOR-I; HEALTHY-YOUNG MEN; IGF-I; BODY-COMPOSITION; SLEEP RESTRICTION; PHYSICAL-ACTIVITY; TESTOSTERONE; HORMONE; INSULIN; SECRETION AB Context: Due to current operational requirements, elite soldiers deploy quickly after completing arduous training courses. Therefore, it is imperative that endocrine and inflammatory mediators have fully recovered. Objective: Our objective was to determine whether a short-term (2-6 wk) recovery period was sufficient to restore endocrine and inflammatory homeostasis after sustained energy deficit. Design: Before and immediately after the course, serum concentrations of inflammatory and endocrine markers were taken along with anthropometric measures prior to and immediately after the Army Ranger course. In addition, nine soldiers were assessed between 2 and 6 weeks after the course. Setting: This research occurred in a field setting during an intensive 8-week military training course characterized by high-energy expenditure, energy restriction, and sleep deprivation (U.S. Army Ranger School). Participants: Twenty-three male soldiers (23.0 +/- 2.8 y; 177.6 +/- 7.9 cm; 81.0 +/- 9.6 kg, 16.8 +/- 3.9% body fat) participated in this study. Interventions: There were no interventions used in this research. Outcome Measures and Results: Significant changes occurred in circulating total testosterone (-70%), brain-derived neurotrophic factor (-33%), total IGF-1 (-38.7%), free IGF-1 (-41%), IGF binding protein (IGFBP-6; -23.4%), sex-hormone binding globulin (+46%), thyroid stimulating hormone (+85%), IGFBP-1 (+534.4%), IGFBP-2 (+98.3%), IGFBP-3 (+14.7%), IL-4 (+135%), IL-6 (+217%), and IL-8 (+101%). Significant changes in body mass (-8%), bicep (-14%), forearm (-5%), thigh (-7%), and calf (-2%) circumferences, sum of skinfolds (-52%), and percentage body fat (-54%). All anthropometric, inflammatory, and hormonal values, except T-3, were restored to baseline levels within 2-6 weeks after the course. Conclusions: Endocrine markers and anthropometric measures were degraded, and inflammatory mediators increased after an extended energy deficit. A short-term recovery of 2-6 weeks was sufficient to restore these mediators. C1 [Henning, Paul C.; Scofield, Dennis E.; Spiering, Barry A.; Staab, Jeffery S.; Matheny, Ronald W., Jr.; Nindl, Bradley C.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Smith, Martha A.] Madigan Healthcare Syst, Joint Base Lewis Mcchord, WA 98431 USA. [Bhasin, Shalender] Boston Univ, Sch Med, Endocrinol Sect, Boston, MA 02118 USA. [Bhasin, Shalender] Boston Univ, Sch Med, Sect Diabet, Boston, MA 02118 USA. [Bhasin, Shalender] Boston Univ, Sch Med, Sect Nutr, Boston, MA 02118 USA. [Nindl, Bradley C.] Army Inst Publ Hlth Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Henning, PC (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM paul.c.henning@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015 FU Research Area Directorate (RAD) III, Medical Research and Material Command (MRMC) FX This study was funded by Research Area Directorate (RAD) III, Medical Research and Material Command (MRMC). NR 50 TC 10 Z9 10 U1 1 U2 4 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD MAR PY 2014 VL 99 IS 3 BP 956 EP 964 DI 10.1210/jc.2013-3046 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AD7RD UT WOS:000333461600058 PM 24423293 ER PT J AU Gauer, R Belprez, M Rerucha, C AF Gauer, Robert Belprez, Megan Rerucha, Caitlyn TI Pediatric hypertension: Often missed and mismanaged SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID BLOOD-PRESSURE-MEASUREMENT; CHILDREN; ADOLESCENTS; CHILDHOOD; TRENDS; METAANALYSIS; PREVALENCE; REGRESSION; THERAPY; UPDATE C1 [Gauer, Robert; Belprez, Megan; Rerucha, Caitlyn] Womack Army Med Ctr, Family Med Residency Program, Ft Bragg, NC 28307 USA. RP Gauer, R (reprint author), Womack Army Med Ctr, Family Med Residency Program, Ft Bragg, NC 28307 USA. EM robert.l.gauer2.civ@mail.mil NR 41 TC 1 Z9 1 U1 0 U2 1 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD MAR PY 2014 VL 63 IS 3 BP 129 EP 136 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AD8NP UT WOS:000333523200006 PM 24701598 ER PT J AU Suedel, BC Clarke, JU Lutz, CH Clarke, DG Godard-Codding, C Maul, J AF Suedel, Burton C. Clarke, Joan U. Lutz, Charles H. Clarke, Douglas G. Godard-Codding, Celine Maul, Jonathan TI Suspended sediment effects on walleye (Sander vitreus) SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Walleye (Sander vitreus); Suspended sediment; Toxicity; Environmental window; Dredging ID WESTERN LAKE-ERIE; STIZOSTEDION-VITREUM; LARVAL WALLEYE; BELEWS LAKE; LIFE STAGES; FISH; TOXICITY; POPULATIONS; PERFORMANCE; DEFORMITIES AB Environmental windows are seasonal restrictions imposed on dredging operations in the Great Lakes and other waterways of the United States. Such restrictions often generically assume that sediments resuspended by dredging result in adverse impacts to fish; this is the case in western Lake Erie where the environmental window was established due to potential impacts on walleye (Sander vitreus). To address this concern, laboratory studies mimicking sediment resuspension during dredging operations in western Lake Erie were conducted to determine whether suspended sediments affect walleye eggs and fingerlings. Newly laid eggs and 45- to 60-d old fingerlings from separate hatcheries were exposed for 72-h under flow-through conditions to 0, 100, 250, and 500 mg/L total suspended sediment (TSS). Fingerlings, eggs, and newly hatched larvae were analyzed for multiple lethal and sublethal endpoints. Data indicated no significant effects of suspended sediment on egg hatch success or fingerling survival after three days of exposure. No significant differences were observed when comparing percent egg viability in the control with any TSS treatment; however, a downward trend was observed at 500 mg/L. No significant differences were observed during comparisons of fingerling gill lamellae in the control with any TSS treatment; however, a statistically significant difference was observed when comparing gill lamellae in the control with the original supply animals. No significant differences were found between control means and unexposed eggs or any TSS treatment. These effect data for walleye will serve to better inform the setting of environmental windows for this species in western Lake Erie. Published by Elsevier B.V. on behalf of International Association for Great lakes Research. C1 [Suedel, Burton C.; Clarke, Joan U.; Lutz, Charles H.; Clarke, Douglas G.] US Army, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Godard-Codding, Celine; Maul, Jonathan] Texas Tech Univ, Inst Environm & Human Hlth, Dept Environm Toxicol, Lubbock, TX 79409 USA. RP Suedel, BC (reprint author), US Army, Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil; joan.clarke@usace.army.mil; charles.h.lutz@usace.army.mil; douglas.g.clarke@usace.army.mil; celine.godard-codding@tiehh.ttu.edu; jonathan.maul@tiehh.ttu.edu FU Dredging Operations and Environmental Research Program FX We thank Pat Howard of the Hebron State Fish Hatchery, Ohio and Justin Wilkins of the North Mississippi Fish Hatchery and their staffs for their assistance in providing eggs and fingerlings. We thank Jeff Tyson and Kevin Kayle, Ohio Department of Natural Resources Division of Wildlife for reviewing an earlier version of the paper. We thank Scott Pickard of the Buffalo District Corps of Engineers for coordination of sediment collection and experimental design insight, and review of an earlier version of the paper, and Cynthia Banks and Robert Boyd for expert technical assistance. This research was funded by the Dredging Operations and Environmental Research Program, Todd Bridges, Director. Permission was granted by the Chief of Engineers to publish this material. NR 45 TC 1 Z9 2 U1 3 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD MAR PY 2014 VL 40 IS 1 BP 141 EP 148 DI 10.1016/j.jglr.2013.12.008 PG 8 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AD8XN UT WOS:000333549100014 ER PT J AU Jabbour, RE Deshpande, SV McCubbin, PE Wright, JD Wade, MM Snyder, AP AF Jabbour, Rabih E. Deshpande, Samir V. McCubbin, Patrick E. Wright, James D. Wade, Mary Margaret Snyder, A. Peter TI Extracellular protein biomarkers for the characterization of enterohemorrhagic and enteroaggregative Escherichia coli strains SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Electrospray; Liquid chromatography-tandem mass spectrometry; Proteomics; Enterohemorrhagic E. coli; Enteroaggregative E. coli; Extracellular proteins ID SPECTROMETRY-BASED PROTEOMICS; MASS-SPECTROMETRY; IDENTIFICATION; SECRETOME; CLASSIFICATION; DATABASE; GENOME; CELLS; MS/MS AB The extracellular proteins (ECPs) of enterohemorrhagic Escherichia coli (EHEC) can cause hemorrhagic colitis which may cause life threatening hemolytic-uremic syndrome, while that of enteroaggregative E. coli (EAEC) can clump to intestinal membranes. Liquid chromatography-electrospray ionization-tandem mass spectrometry based proteomics is used to evaluate a preliminary study on the extracellular and whole cell protein extracts associated with E. coli strain pathogenicity. Proteomics analysis, which is independent of genomic sequencing, of EAEC O104:H4 (unsequenced genome) identified a number of proteins. Proteomics of EHEC O104:H4, causative agent of the Germany outbreak, showed a closest match with E. colo E55989, in agreement with genomic studies. Dendrogram analysis separated EHEC O157:H7 and EHEC/EAEC O104:H4. ECP analysis compared to that of whole cell processing entails few steps and convenient experimental extraction procedures. Bacterial characterization results are promising in exploring the impact of environmental conditions on E. coli ECP biomarkers with a few relatively straightforward protein extraction steps. Published by Elsevier B.V. C1 [Jabbour, Rabih E.; Wright, James D.; Wade, Mary Margaret; Snyder, A. Peter] US Army, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Deshpande, Samir V.] Sci & Technology Corp Edgewood, Edgewood, MD 21040 USA. [McCubbin, Patrick E.] Optimetr Inc, Abingdon, MD 21009 USA. RP Snyder, AP (reprint author), Bldg E3160,ECBC,Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. EM arnold.p.snyder.civ@mail.mil FU US Army Edgewood Chemical Biological Center FX The authors wish to thank the US Army Edgewood Chemical Biological Center for financial support of this work under the Research and Technology (R&T) Directorate 2013 In-House Laboratory Independent Research (ILIR) Basic Research portfolio and Dr. Augustus Way Fountain III for management of this program. NR 24 TC 0 Z9 0 U1 3 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD MAR PY 2014 VL 98 BP 76 EP 83 DI 10.1016/j.mimet.2013.12.017 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA AE3BU UT WOS:000333852700014 PM 24389036 ER PT J AU Fresconi, F Celmins, I Ilg, M Maley, J AF Fresconi, Frank Celmins, Ilmars Ilg, Mark Maley, James TI Projectile Roll Dynamics and Control with a Low-Cost Maneuver System SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID CANARD-CONTROLLED MISSILE; GUIDANCE C1 [Fresconi, Frank; Celmins, Ilmars; Maley, James] US Army, Res Lab, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ilg, Mark] US Army, Res Lab, GNC Applicat, Lethal Div,Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Fresconi, F (reprint author), US Army, Res Lab, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 7 Z9 8 U1 4 U2 5 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR-APR PY 2014 VL 51 IS 2 BP 624 EP + DI 10.2514/1.A32553 PG 4 WC Engineering, Aerospace SC Engineering GA AE1VT UT WOS:000333759900022 ER PT J AU Klein, B Gautam, N Plis, E Schuler-Sandy, T Rotter, TJ Krishna, S Connelly, BC Metcalfe, GD Shen, P Wraback, M AF Klein, Brianna Gautam, Nutan Plis, Elena Schuler-Sandy, Ted Rotter, Thomas J. Krishna, Sanjay Connelly, Blair C. Metcalfe, Grace D. Shen, Paul Wraback, Michael TI Carrier lifetime studies in midwave infrared type-II InAs/GaSb strained layer superlattice SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MOLECULAR-BEAM EPITAXY; INTERFACE STRUCTURE; V-SEMICONDUCTORS; GASB; HETEROSTRUCTURES; RECOMBINATION; CENTERS; INAS AB The authors report on an investigation of the dependence of the minority carrier lifetime in midwave infrared InAs/GaSb strained layer superlattices on a number of varied parameters: layer placement of two dopants (either Be or Te), and interface treatment between InAs and GaSb layers. In samples where the dopant and doping location was varied, it was found that the nonintentionally doped control sample exhibited the longest lifetimes (similar to 49 ns at 77K under low injection), followed by the Be-doped and the Te-doped samples. Regardless of the type of doping, samples with dopants in only the InAs layer appeared to have longer lifetimes [low injection: 15 ns (Be), <3 ns (Te); high injection: 38 ns (Be), 16.2 ns (Te) at 77 K] compared to samples with dopants in the GaSb layer or all layers. However, because trap saturation behavior was observed in the transient photoluminescence (PL) decay, the intensity-dependent PL lifetime is a function of both the minority and majority carrier lifetimes, complicating the interpretation of the data. In samples where the treatment of the InAs/GaSb interface was varied, the sample that demonstrated the longest lifetime had a one-period growth sequence of InAs, an Sb soak, GaSb, and an InSb strain compensation layer. Of the three interface samples investigated, the sample (with a growth sequence of InAs, an Sb soak, GaSb, and a growth interrupt) that demonstrated the shortest lifetime also exhibited a fast initial decay for all injection levels, at only 110 and 150 K. This fast initial decay has been attributed to the appearance of another Shockley-Read-Hall trap level, contributing to a shorter carrier lifetime. (C) 2014 American Vacuum Society. C1 [Klein, Brianna; Gautam, Nutan; Plis, Elena; Schuler-Sandy, Ted; Rotter, Thomas J.; Krishna, Sanjay] Univ New Mexico, Ctr High Technol Mat, Albuquerque, NM 87106 USA. [Connelly, Blair C.; Metcalfe, Grace D.; Shen, Paul; Wraback, Michael] US Army, RDRL SEE M, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Klein, B (reprint author), Univ New Mexico, Ctr High Technol Mat, 1313 Goddard St SE Albuquerque, Albuquerque, NM 87106 USA. EM bklein01@unm.edu FU United States Government FX Support for this project was provided by the United States Government. NR 34 TC 14 Z9 14 U1 3 U2 39 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAR PY 2014 VL 32 IS 2 AR 02C101 DI 10.1116/1.4862085 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA AD9BW UT WOS:000333560600009 ER PT J AU Fujii, DE Ahmed, L AF Fujii, Daryl E. Ahmed, Iqbal TI Psychotic Disorder Caused by Traumatic Brain Injury SO PSYCHIATRIC CLINICS OF NORTH AMERICA LA English DT Article DE Psychosis; Mental disorder; Brain; Trauma ID PSYCHIATRIC-DISORDERS; CHRONIC-SCHIZOPHRENIA; NEGATIVE SYMPTOMS; HEAD-INJURY; RISK; PREVALENCE; EPILEPSY; ILLNESS; HOSPITALIZATION; HALLUCINATIONS AB Psychosis is a rare and severe sequela of traumatic brain injury (TBI). This article assists clinicians in differential diagnosis by providing literature-based guidance with regard to use of the Diagnostic and Statistical Manual for Mental Disorders 5 criteria for this condition. This article also describes potential relationships between TBI and the development of a psychosis within the conceptualization of psychosis as a neurobehavioral syndrome. C1 [Fujii, Daryl E.] Community Living Ctr, Vet Affairs Pacific Isl Hlth Care Serv, Honolulu, HI 96819 USA. [Ahmed, Iqbal] Univ Hawaii, Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. [Ahmed, Iqbal] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Fujii, DE (reprint author), Community Living Ctr, Vet Affairs Pacific Isl Hlth Care Serv, 459 Patterson Rd, Honolulu, HI 96819 USA. EM dfujii07@gmail.com NR 54 TC 6 Z9 6 U1 2 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0193-953X EI 1558-3147 J9 PSYCHIAT CLIN N AM JI Psychiatr. Clin. North Amer. PD MAR PY 2014 VL 37 IS 1 BP 113 EP + DI 10.1016/j.psc.2013.11.006 PG 13 WC Psychiatry SC Psychiatry GA AD8UM UT WOS:000333541200009 PM 24529427 ER PT J AU Wright, GD Harner, MJ Chambers, JD AF Wright, Greg D. Harner, Mary J. Chambers, James D. TI UNUSUAL WINTERING DISTRIBUTION AND MIGRATORY BEHAVIOR OF THE WHOOPING CRANE (GRUS AMERICANA) IN 2011-2012 SO WILSON JOURNAL OF ORNITHOLOGY LA English DT Article DE Aransas National Wildlife Refuge; Cheyenne Bottoms State Waterfowl Management Area, Kansas; climate; Granger Lake, Texas; Platte River, Nebraska; Quivira National Wildlife Refuge, Kansas; Whooping Crane; wintering habitat AB The last, self-sustaining population of Whooping Cranes (Grus americana), the Aransas-Wood Buffalo population, has overwintered almost exclusively along the Gulf Coast of Texas, USA, in and around the Aransas National Wildlife Refuge during recent decades. In late autumn and winter 2011-2012, Whooping Cranes were observed several hundred kilometers from coastal wintering grounds, with at least 13 Whooping Cranes in central Texas, south-central Kansas, and central Nebraska from November 2011 to early March 2012. Notably, family groups of Whooping Cranes were observed around a Texas reservoir, Granger Lake, over a 3-month period. An extreme drought, coupled with record warm temperatures in the southern and central United States, may have interacted to influence behaviors and distributions of Whooping Cranes during winter 2011-2012. Such observations suggest that Whooping Cranes may be more opportunistic in use of wintering habitat and/or more likely to re-colonize inland historical sites than previously thought. Continued documentation of Whooping Cranes overwintering in areas other than the Texas coast and/or altering timing of migration will be important for protection and management of additional winter habitat as well as for informing population estimates for the Aransas-Wood Buffalo Population of Whooping Cranes. C1 [Wright, Greg D.; Harner, Mary J.] Crane Trust, Wood River, NE 68883 USA. [Chambers, James D.] US Army Corps Engineers, Granger, TX 76530 USA. RP Wright, GD (reprint author), Crane Trust, 6611 W Whooping Crane Dr, Wood River, NE 68883 USA. EM gwright@cranetrust.org FU Crane Trust FX We thank two anonymous reviewers, A. T. Pearse, K. Geluso, and J. D. Oates for comments on earlier versions of this manuscript. We thank regional biologists, land managers, and the public for reporting sightings of Whooping Cranes. The Crane Trust provided funding for this research. NR 18 TC 1 Z9 2 U1 4 U2 29 PU WILSON ORNITHOLOGICAL SOC PI WACO PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710 USA SN 1559-4491 EI 1938-5447 J9 WILSON J ORNITHOL JI Wilson J. Ornithol. PD MAR PY 2014 VL 126 IS 1 BP 115 EP 120 PG 6 WC Ornithology SC Zoology GA AD9GN UT WOS:000333573100015 ER PT J AU Hart, EC Wallin, BG Barnes, JN Joyner, MJ Charkoudian, N AF Hart, Emma C. Wallin, B. Gunnar Barnes, Jill N. Joyner, Michael J. Charkoudian, Nisha TI Sympathetic nerve activity and peripheral vasodilator capacity in young and older men SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE aging; sympathetic; vasodilation ID ALPHA-ADRENERGIC VASOCONSTRICTION; ARTERIAL-PRESSURE REGULATION; BLOOD-PRESSURE; HEALTHY-MEN; NITRIC-OXIDE; HEMODYNAMIC BALANCE; HUMAN LIMBS; HUMANS; AGE; MUSCLE AB Interindividual variability in sympathetic nerve activity (SNA) has provided insight into integrative mechanisms contributing to blood pressure (BP) regulation in humans. In young people, the influence of high SNA on BP is balanced by lower cardiac output and less adrenergic vasoconstrictor responsiveness. Older people have higher SNA and higher BP. We hypothesized that SNA has a restraining effect on peripheral vasodilator responsiveness in young and older men, such that individuals with higher tonic SNA would show less forearm vasodilatation to exogenous vasodilators. We measured muscle SNA (MSNA; microneurography) and forearm vasodilator responses to intra-arterial infusions of acetylcholine (ACh; endothelium dependent) and sodium nitroprusside (SNP; endothelium independent) in 13 young (age; 27 +/- 1 yr) and 16 older (61 +/- 2 yr) men. Forearm vascular conductance (FVC) responses to ACh were lower in the older men at the two highest doses (2 and 4 mu g.100 ml(-1).min(-1); Delta 395 +/- 81 vs. 592 +/- 87% and 412 +/- 87 vs. 616 +/- 132%, P < 0.05), and MSNA was higher (64 +/- 4 vs. 41 +/- 2 bursts/100 hb; P < 0.05). There was no difference in the FVC response to SNP between young and older men (P > 0.05). In young men, there was an inverse relationship between resting MSNA and FVC responses (%change) to both ACh and SNP (r = -0.83 and r = -0.83, respectively; P < 0.05). In older men, however, this relationship was not observed. Tonic SNA may act to restrain vasodilator responses in young men, whereas in older men a lack of such restraint may be protective against the pressor effects of higher SNA. C1 [Hart, Emma C.; Barnes, Jill N.; Joyner, Michael J.; Charkoudian, Nisha] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [Hart, Emma C.] Univ Bristol, Dept Physiol & Pharmacol, Bristol BS8 1TD, Avon, England. [Wallin, B. Gunnar] Gothenburg Univ, Inst Neurosci & Physiol, Sahlgren Acad, Gothenburg, Sweden. [Charkoudian, Nisha] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Hart, EC (reprint author), Univ Bristol, Dept Physiol & Pharmacol, Bristol BS8 1TD, Avon, England. EM emma.hart@bristol.ac.uk OI Hart, Emma/0000-0002-4534-9586 FU British Heart Foundation [FS/11/1/28400] NR 26 TC 10 Z9 10 U1 1 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 EI 1522-1539 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD MAR PY 2014 VL 306 IS 6 BP H904 EP H909 DI 10.1152/ajpheart.00181.2013 PG 6 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA AD6AC UT WOS:000333333900013 PM 24414063 ER PT J AU Labukas, JP Escarsega, JA Crawford, DM AF Labukas, Joseph P. Escarsega, John A. Crawford, Dawn M. TI Accelerated drying of water-dispersible polyurethane blends SO JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH LA English DT Article DE Accelerated drying of water-dispersible polyurethane blends; Water-dispersible chemical agent-resistant coatings; Rapid cure; Camouflage; CARC ID URETHANE-ACRYLATE COATINGS; UV; NANOCOMPOSITES; POLYMER; SYSTEMS; CLAY AB Mixtures of water-dispersible isocyanate and polyol-terminated oligomers were blended with methacrylate-terminated urethanes and a water-dispersible photoinitiator to accelerate the dry time of thin polymer films. Thermomechanical properties of the polyurethane blends were measured using dynamic mechanical analysis. Kinetics of the ultraviolet-initiated radical polymerization reaction and the polyol/isocyanate addition reaction were monitored using attenuated total reflectance-Fourier transform infrared spectroscopy. C1 [Labukas, Joseph P.; Escarsega, John A.; Crawford, Dawn M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Escarsega, JA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.a.escarsega.civ@mail.mil NR 34 TC 1 Z9 1 U1 0 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1547-0091 EI 1935-3804 J9 J COAT TECHNOL RES JI J. Coat. Technol. Res. PD MAR PY 2014 VL 11 IS 2 BP 217 EP 229 DI 10.1007/s11998-013-9536-9 PG 13 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA AD3QL UT WOS:000333160800011 ER PT J AU Ona, CM Onoye, JM Goebert, D Hishinuma, E Bumanglag, RJ Takeshita, J Carlton, B Fukuda, M AF Ona, Celia M. Onoye, Jane M. Goebert, Deborah Hishinuma, Earl Bumanglag, R. Janine Takeshita, Junji Carlton, Barry Fukuda, Michael TI Sociodemographic Characterization of ECT Utilization in Hawaii SO JOURNAL OF ECT LA English DT Article DE ECT; treatment utilization; Asian Americans; ethnicity; Pacific Islanders ID RECURRENT MAJOR DEPRESSION; ELECTROCONVULSIVE-THERAPY; ASIAN-AMERICANS; HELP-SEEKING; SUICIDAL IDEATION; OUTPATIENTS; DISORDER; JAPAN; CARE AB Objectives Minimal research has been done on sociodemographic differences in utilization of electroconvulsive therapy (ECT) for refractory depression, especially among Asian Americans and Pacific Islanders. Methods This study examined sociodemographic and diagnostic variables using retrospective data from Hawaii, an island state with predominantly Asian Americans and Pacific Islanders. Retrospective data were obtained from an inpatient and outpatient database of ECT patients from 2008 to 2010 at a tertiary care community hospital on O'ahu, Hawaii. Results There was a significant increase in overall ECT utilization from 2008 to 2009, with utilization remaining stable from 2009 to 2010. European Americans (41%) and Japanese Americans (29%) have relatively higher rates of receiving ECT, and Filipino Americans and Native Hawaiians have relatively lower rates in comparison with their population demographics. Japanese Americans received significantly more ECT procedures than European Americans. Conclusions Electroconvulsive therapy is underutilized by certain sociodemographic groups that may benefit most from the treatment. There are significant differences in ECT usage based on ethnicity. Such differences may be related to help-seeking behavior, economic differences, and/or attitudes regarding mental illness. Further research is needed to elucidate the reasons for differences in utilization. C1 [Ona, Celia M.] Univ Hawaii Manoa, Tripler Army Med Ctr, John A Burns Sch Med, Honolulu, HI 96813 USA. [Ona, Celia M.; Onoye, Jane M.; Goebert, Deborah; Hishinuma, Earl; Bumanglag, R. Janine; Takeshita, Junji; Carlton, Barry; Fukuda, Michael] Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, Honolulu, HI 96813 USA. [Onoye, Jane M.; Goebert, Deborah; Takeshita, Junji; Carlton, Barry] Queens Med Ctr, Honolulu, HI USA. RP Onoye, JM (reprint author), Univ Hawaii Manoa, Dept Psychiat, John A Burns Sch Med, 1356 Lusitana St,4th Floor, Honolulu, HI 96813 USA. EM onoyej@dop.hawaii.edu FU The Queen's Medical Center FX This research and dissemination were supported, in part, by a grant from The Queen's Medical Center, which also reviewed but did not edit this article. Drs. Onoye and Goebert are faculty of the University of Hawaii John A. Burns School of Medicine, as well as senior scientists at The Queen's Medical Center. Drs. Takeshita and Carlton are also affiliated with The Queen's Medical Center. Dr. Ona was previously affiliated with The Queen's Medical Center. The contents of this article are solely the responsibility of the authors and do not represent the official views, policy, or position of The Queen's Medical Center, the University of Hawaii, the Army, the Department of Defense, or the US Government. A portion of this article was presented at the American Psychiatric Association's Annual Meeting in May 2011 in Honolulu, Hawaii. NR 38 TC 2 Z9 2 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1095-0680 EI 1533-4112 J9 J ECT JI J. ECT PD MAR PY 2014 VL 30 IS 1 BP 43 EP 46 DI 10.1097/YCT.0000000000000075 PG 4 WC Behavioral Sciences; Psychiatry SC Behavioral Sciences; Psychiatry GA AC2DJ UT WOS:000332307600016 PM 24080537 ER PT J AU Nakama, H Garcia, A O'Brien, K Ellis, N AF Nakama, Helenna Garcia, Alissa O'Brien, Kendra Ellis, Nathan TI Case Report of a 24-Year-Old Man With Resolution of Treatment-Resistant Major Depressive Disorder and Comorbid PTSD Using rTMS SO JOURNAL OF ECT LA English DT Letter DE MDD; PTSD; TMS; transcranial magnetic stimulation; depression; posttraumatic stress disorder ID TRANSCRANIAL MAGNETIC STIMULATION; POSTTRAUMATIC-STRESS-DISORDER AB Although there is a large amount of literature indicating the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depressive disorder (trMDD),(1) the authors did not find any literature supporting rTMS for MDD with the comorbid condition of posttraumatic stress disorder (PTSD). Here, we report an original case of a patient whose trMDD and PTSD remitted using rTMS at the left dorsolateral prefrontal cortex. C1 [Nakama, Helenna; Garcia, Alissa; O'Brien, Kendra; Ellis, Nathan] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI 96859 USA. RP Nakama, H (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM helenna.h.nakama.civ@mail.mil NR 5 TC 1 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1095-0680 EI 1533-4112 J9 J ECT JI J. ECT PD MAR PY 2014 VL 30 IS 1 BP E9 EP E10 DI 10.1097/YCT.0b013e182a2705d PG 2 WC Behavioral Sciences; Psychiatry SC Behavioral Sciences; Psychiatry GA AC2DJ UT WOS:000332307600008 PM 24553322 ER PT J AU Villamaria, CY Morrison, JJ Fitzpatrick, CM Cannon, JW Rasmussen, TE AF Villamaria, Carole Y. Morrison, Jonathan J. Fitzpatrick, Colleen M. Cannon, Jeremy W. Rasmussen, Todd E. TI Wartime vascular injuries in the pediatric population of Iraq and Afghanistan: 2002-2011 SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE Vascular injury; Trauma; Children; Pediatric; Wartime; Reconstruction ID CHILDREN; TRAUMA; MANAGEMENT; WAR AB Background: Contemporary war-related studies focus primarily on adults with few reporting the injuries sustained in local pediatric populations. The objective of this study is to characterize pediatric vascular trauma at US military hospitals in wartime Iraq and Afghanistan. Methods: Review of the Department of Defense Trauma Registry (DoDTR) (2002-2011) identified patients (1-17 years old) treated at US military hospitals in Iraq and Afghanistan using ICD-9 and procedure codes for vascular injury. Results: US military hospitals treated 4402 pediatric patients between 2002 and 2011. One hundred fifty-five patients (3.5%) had a vascular injury. Mean age, gender, and injury severity score (ISS) were 11.1 +/- 4.1 years, 79% male, and 34 +/- 13.5, respectively. Vascular injuries were primarily from penetrating mechanisms (95.6%; 58.0% blast injury) to the extremity (65.9%), torso (25.4%), and neck (8.6%). Injuries were ligated (31%), reconstructed (63%), or observed (2%). Limb salvage rate was 95%. Mortality rate was 9%. Conclusions: This study is the first to report vascular trauma in a pediatric population at wartime. Vascular injuries involve a high percentage of extremity and torso wounding. Torso vascular injury in children is four times lethal relative to other injury patterns, and therefore should be considered in operational planning both in the military and civilian setting regarding pediatric vascular injuries. Published by Elsevier Inc. C1 [Villamaria, Carole Y.; Rasmussen, Todd E.] 59 MDW Wilford Hall Ambulatory Surg Ctr, Lackland AFB, TX 78236 USA. [Villamaria, Carole Y.; Morrison, Jonathan J.; Rasmussen, Todd E.] US Army, Inst Surg Res, San Antonio, TX USA. [Fitzpatrick, Colleen M.] St Louis Univ, CSTARS, St Louis, MO 63103 USA. [Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Villamaria, CY (reprint author), US Army, Inst Surg Res, Houston, TX 78234 USA. EM cvillamaria@gmail.com; jjmorrison@outlook.com; colleen.fitzpatrick@amedd.army.mil; jcannon@massmed.org; todd.e.rasmussen.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 18 TC 5 Z9 5 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 EI 1531-5037 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD MAR PY 2014 VL 49 IS 3 BP 428 EP 432 DI 10.1016/j.jpedsurg.2013.10.002 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA AD2HP UT WOS:000333055700011 PM 24650471 ER PT J AU Kent, D Neiner, J AF Kent, David Neiner, James TI A SPLIT FACE EVALUATION OF A NOVEL TOPICAL OXYGEN EMULSION ON THE HEALING PROCESS FOLLOWING PHOTODYNAMIC THERAPY: A PILOT STUDY SO LASERS IN SURGERY AND MEDICINE LA English DT Meeting Abstract CT 34th Annual Conference of the American-Society-for-Laser-Medicine-and-Surgery (ASLMS) CY APR 02-06, 2014 CL Phoenix, AZ SP Amer Soc Laser Med & Surg C1 [Kent, David; Neiner, James] US Army Med Corps, Macon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0196-8092 EI 1096-9101 J9 LASER SURG MED JI Lasers Surg. Med. PD MAR PY 2014 VL 46 SU 25 MA 141 BP 45 EP 45 PG 1 WC Dermatology; Surgery SC Dermatology; Surgery GA AD2HQ UT WOS:000333055800128 ER PT J AU Ferguson, JB Schultz, BF Venugopalan, D Lopez, HF Rohatgi, PK Cho, K Kim, CS AF Ferguson, J. B. Schultz, Benjamin F. Venugopalan, Dev Lopez, Hugo F. Rohatgi, Pradeep K. Cho, Kyu Kim, Chang-Soo TI On the superposition of strengthening mechanisms in dispersion strengthened alloys and metal-matrix nanocomposites: Considerations of stress and energy SO METALS AND MATERIALS INTERNATIONAL LA English DT Article DE nanostructured materials; composites; strength; mechanical properties; yield phenomena ID ALTERNATIVE PHYSICAL EXPLANATION; MELTED SIC/AL COMPOSITES; HALL-PETCH RELATION; SILICON-CARBIDE; YIELD STRENGTH; GRAIN-SIZE; ALUMINUM; MICROSTRUCTURE; BEHAVIOR; TENSILE AB Yield strength improvement in dispersion strengthened alloys and nano particle-reinforced composites by well-known strengthening mechanisms such as solid solution, grain refinement, coherent and incoherent dispersed particles, and increased dislocation density resulting from work-hardening can all be described individually. However, there is no agreed upon description of how these mechanisms combine to determine the yield strength. In this work, we propose an analytical yield strength prediction model combining arithmetic and quadratic addition approaches based on the consideration of two types of yielding mechanisms; stress-activated and energy-activated. Using data available in the literature for materials of differing grain sizes, we consider the cases of solid solutions and coherent precipitates to show that they follow stress-activated behavior. Then, we applied our model with some empirical parameters to precipitationhardenable materials of various grain sizes in both coherent and incoherent precipitate conditions, which demonstrated that grain boundary and Orowan-strengthening can be treated as energy-activated mechanisms. C1 [Ferguson, J. B.; Schultz, Benjamin F.; Venugopalan, Dev; Lopez, Hugo F.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu RI Schultz, Benjamin/H-8229-2014 OI Schultz, Benjamin/0000-0002-0235-7674 FU U.S. Army Research Laboratory [W911NF-08-2-0014]; University of Wisconsin-Milwaukee (UWM) Research Growth Initiative (RGI) Award FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. C-S Kim and PK Rohatgi also acknowledge the partial support by the University of Wisconsin-Milwaukee (UWM) Research Growth Initiative (RGI) Award. NR 39 TC 5 Z9 5 U1 4 U2 23 PU KOREAN INST METALS MATERIALS PI SEOUL PA KIM BLDG 6TH FLOOR, SEOCHO-DAERO 56 GIL 38, SEOCHO-GU, SEOUL 137-881, SOUTH KOREA SN 1598-9623 EI 2005-4149 J9 MET MATER INT JI Met. Mater.-Int. PD MAR PY 2014 VL 20 IS 2 BP 375 EP 388 DI 10.1007/s12540-014-2017-6 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AD3IF UT WOS:000333130900025 ER PT J AU Paranavitana, C DaSilva, L Vladimirova, A Pittman, PR Velauthapillai, M Nikolich, M AF Paranavitana, Chrysanthi DaSilva, Luis Vladimirova, Antoaneta Pittman, Phillip R. Velauthapillai, Mahendran Nikolich, Mikeljon TI Transcriptional profiling of recall responses to Francisella live vaccine strain SO PATHOGENS AND DISEASE LA English DT Article ID NATURAL-KILLER-CELLS; CD8(+) T-CELLS; PLASMACYTOID DENDRITIC CELLS; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; TULAREMIA VACCINE; ADAPTIVE IMMUNITY; GAMMA-INTERFERON; HOST-DEFENSE; TULARENSIS LVS C1 [Paranavitana, Chrysanthi; Nikolich, Mikeljon] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [DaSilva, Luis] US Army Med Res Inst Infect Dis USAMRIID, Ctr Aerobiol Sci, Frederick, MD USA. [Vladimirova, Antoaneta] Ingenu Syst, Redwood City, CA USA. [Pittman, Phillip R.] US Army Med Res Inst Infect Dis USAMRIID, Div Med, Frederick, MD USA. [Velauthapillai, Mahendran] Georgetown Univ, Dept Comp Sci, Washington, DC USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Bldg 503,Rm 3N72, Silver Spring, MD 20910 USA. EM chrysanthi.m.paranavitana2.ctr@us.army.mil FU Defense Threat Reduction Agency (DTRA) of the Department of Defense FX We thank Dr Manmohan Ranadive, Mr Lawrence Korman, and Ms Aimee Porter for their help with the Human Use protocol and collection of blood samples. We thank Ms Amy Michels for editing the manuscript. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Air Force, or the Department of Defense. This work was supported by a grant to C.P. from the Defense Threat Reduction Agency (DTRA) of the Department of Defense. NR 66 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2049-632X J9 PATHOG DIS JI Pathog. Dis. PD MAR PY 2014 VL 70 IS 2 BP 141 EP 152 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AC8GM UT WOS:000332771500005 PM 24453125 ER PT J AU Albanese, M De Benedictis, A Jajodia, S Torrieri, D AF Albanese, Massimiliano De Benedictis, Alessandra Jajodia, Sushi Torrieri, Don TI A probabilistic framework for jammer identification in MANETs SO AD HOC NETWORKS LA English DT Article DE Jammer localization; MANET; Probabilistic framework ID LOCALIZATION AB Cyber maneuver is envisioned as a way of increasing the robustness of imperfect systems by creating and deploying mechanisms that continually change a system's attack surface. A particularly useful strategy against jamming attacks in Mobile Ad Hoc Networks (MANETs) entails using cyber-maneuver keys to supplement higher-level cryptographic keys. Such keys can be periodically changed either in a proactive fashion - to defeat cryptanalytic efforts by external attackers - or in a reactive fashion - to exclude compromised internal nodes. In order to enable effective reactive rekeying, it is critical to correctly identify compromised nodes. In this paper, we propose a probabilistic framework for identifying jammers, based on the location of both jammed and non-jammed nodes. We are interested in finding the smallest set of nodes that need to be excluded to stop the attacks in a multi-jammer scenario. We show that this problem is NP-hard, and propose a polynomial-time heuristic algorithm to find approximate solutions. Experiments show that our approach works well in practice, and that the algorithm is efficient and achieves good precision and recall. (C) 2013 Elsevier B.V. All rights reserved. C1 [Albanese, Massimiliano; Jajodia, Sushi] George Mason Univ, Ctr Secure Informat Syst, Fairfax, VA 22030 USA. [De Benedictis, Alessandra] Univ Naples Federico II, Dept Elect Engn & Informat Technol, Naples, Italy. [Torrieri, Don] US Army Res Lab, Adelphi, MD 20783 USA. RP Albanese, M (reprint author), George Mason Univ, Ctr Secure Informat Syst, Fairfax, VA 22030 USA. EM malbanes@gmu.edu; alessandra.debenedictis@unina.it; jajodia@gmu.edu; don.j.torrieri.civ@mail.mil OI Albanese, Massimiliano/0000-0002-2675-5810 NR 16 TC 3 Z9 3 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-8705 EI 1570-8713 J9 AD HOC NETW JI Ad Hoc Netw. PD MAR PY 2014 VL 14 BP 84 EP 94 DI 10.1016/j.adhoc.2013.11.007 PG 11 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AC2SD UT WOS:000332353400008 ER PT J AU Johnson, JD Theurer, WM AF Johnson, Jeremy D. Theurer, Wesley M. TI A Stepwise Approach to the Interpretation of Pulmonary Function Tests SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID DIFFUSING-CAPACITY; LUNG-FUNCTION; AIRWAY-OBSTRUCTION; FEV1/FVC RATIO; LOWER LIMIT; DEFICIENCY; SPIROMETRY; ADULT; EMPHYSEMA; DISEASE AB Office-based pulmonary function testing, also known as spirometry, is a powerful tool for primary care physicians to diagnose and manage respiratory problems. An obstructive defect is indicated by a low forced expiratory volume in one second/forced vital capacity (FEV1/FVC) ratio, which is defined as less than 70% or below the fifth percentile based on data from the Third National Health and Nutrition Examination Survey (NHANES III) in adults, and less than 85% in patients five to 18 years of age. If an obstructive defect is present, the physician should determine if the disease is reversible based on the increase in FEV1 or FVC after bronchodilator treatment (i.e., increase of more than 12% in patients five to 18 years of age, or more than 12% and more than 200 mL in adults). Asthma is typically reversible, whereas chronic obstructive pulmonary disease is not. A restrictive pattern is indicated by an FVC below the fifth percentile based on NHANES III data in adults, or less than 80% in patients five to 18 years of age. If a restrictive pattern is present, full pulmonary function tests with diffusing capacity of the lung for carbon monoxide testing should be ordered to confirm restrictive lung disease and form a differential diagnosis. If both the FEV1/FVC ratio and the FVC are low, the patient has a mixed defect. The severity of the abnormality is determined by the FEV1 (percentage of predicted). If pulmonary function test results are normal, but the physician still suspects exercise- or allergen-induced asthma, bronchoprovocation (e.g., methacholine challenge, mannitol inhalation challenge, exercise testing) should be considered. (Copyright (C) 2014 American Academy of Family Physicians.) C1 [Johnson, Jeremy D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Theurer, Wesley M.] Madigan Army Med Ctr, Ft Lewis, WA USA. RP Johnson, JD (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeremy.daniel.johnson@us.army.mil NR 45 TC 1 Z9 1 U1 1 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 1 PY 2014 VL 89 IS 5 BP 359 EP 366 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AC8AD UT WOS:000332754500010 PM 24695507 ER PT J AU Kim, YW Mansfield, LT AF Kim, Young W. Mansfield, Liem T. TI Fool Me Twice: Delayed Diagnoses in Radiology With Emphasis on Perpetuated Errors SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE delayed diagnosis; diagnostic errors; error in interpretation ID MISSED LUNG-CANCER; CHEST RADIOGRAPH; CHECKLIST; EXPERIENCE; VARIANTS; SAFETY AB OBJECTIVE. We hypothesized that delayed diagnoses in radiology are not recognized on subsequent radiologic examinations because of multiple types of errors. MATERIALS AND METHODS. Six hundred fifty-six radiologic examinations with delayed diagnoses were collected from July 1, 2002, to January 31, 2010. Each case was reviewed by two radiologists together, and the diagnostic errors were classified according to our modified scheme with consensus between the radiologists. RESULTS. There were a total of 1269 errors. The range of days elapsed from the initial error in interpretation to the correct diagnosis was 0-4611 days, with an average of 251 days. The percentage for each type of error was 0.9% (n = 11) for type 1, 9% (n = 110) for type 2, 3% (n = 39) for type 3, 42% (n = 535) for type 4, approximately 0% (n = 1) for type 5, 2% (n = 29) for type 6, 5% (n = 59) for type 7, 2% (n = 20) for type 8, 7% (n = 92) for type 9, 22% (n = 288) for type 10, 0.5% (n = 6) for type 11, and 6% (n = 79) for type 12. The correct diagnoses were not recognized on subsequent radiologic examinations in 196 of 656 cases (30%). CONCLUSION. Delayed diagnoses were not recognized on subsequent radiologic examinations in about one third of the cases. The most common types of error were underreading, satisfaction of search, faulty reasoning, and location of the finding. C1 [Kim, Young W.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Mansfield, Liem T.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. RP Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM liem_mansfield@hotmail.com NR 33 TC 7 Z9 7 U1 1 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 2014 VL 202 IS 3 BP 465 EP 470 DI 10.2214/AJR.13.11493 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AC4SK UT WOS:000332510900021 PM 24555582 ER PT J AU Sundin, J Herrell, RK Hoge, CW Fear, NT Adler, AB Greenberg, N Riviere, LA Thomas, JL Wessely, S Bliese, PD AF Sundin, Josefin Herrell, Richard K. Hoge, Charles W. Fear, Nicola T. Adler, Amy B. Greenberg, Neil Riviere, Lyndon A. Thomas, Jeffrey L. Wessely, Simon Bliese, Paul D. TI Mental health outcomes in US and UK military personnel returning from Iraq SO BRITISH JOURNAL OF PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PERSIAN-GULF-WAR; ARMED-FORCES; ALCOHOL-USE; COMBAT DEPLOYMENT; SOMATIC SYMPTOMS; PTSD SYMPTOMS; RISK-TAKING; VETERANS; SOLDIERS AB Background Research of military personnel who deployed to the conflicts in Iraq or Afghanistan has suggested that there are differences in mental health outcomes between UK and US military personnel. Aims To compare the prevalence of post-traumatic stress disorder (PTSD), hazardous alcohol consumption, aggressive behaviour and multiple physical symptoms in US and UK military personnel deployed to Iraq. Method Data were from one US (n = 1560) and one UK (n = 313) study of post-deployment military health of army personnel who had deployed to Iraq during 2007-2008. Analyses were stratified by high- and low-combat exposure. Results Significant differences in combat exposure and sociodemographics were observed between US and UK personnel; controlling for these variables accounted for the difference in prevalence of PTSD, but not in the total symptom level scores. Levels of hazardous alcohol consumption (low-combat exposure: odds ratio (OR)=0.13, 95% CI 0.07-0.21; high-combat exposure: OR=0.23, 95% CI 0.14-039) and aggression (low-combat exposure: OR=0.36, 95% CI 0.19-0.68) were significantly lower in US compared with UK personnel. There was no difference in multiple physical symptoms. Conclusions Differences in self-reported combat exposures explain most of the differences in reported prevalence of PTSD. Adjusting for self-reported combat exposures and sociodemographics did not explain differences in hazardous alcohol consumption or aggression. C1 [Sundin, Josefin; Greenberg, Neil] Kings Coll London, ACDMH, London SE5 9RJ, England. [Herrell, Richard K.; Hoge, Charles W.; Riviere, Lyndon A.; Thomas, Jeffrey L.; Bliese, Paul D.] US Army, Med Res & Mat Command, Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Silver Spring, MD USA. [Fear, Nicola T.; Wessely, Simon] Kings Coll London, KCMHR, London SE5 9RJ, England. [Adler, Amy B.] US Army Med Res & Mat Command, US Army Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. RP Fear, NT (reprint author), Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, 10 Cutcombe Rd, London SE5 9RJ, England. RI Wessely, Simon/A-8713-2008; OI Sundin, Josefin/0000-0002-0609-586X FU UK Ministry of Defence US; US Army's Military Operational Medicine Research Program FX J.S., N.T.F., N.G. and S.W. are based at King's College London, which receives funding from the UK Ministry of Defence US funding for this work comes from the US Army's Military Operational Medicine Research Program. NR 49 TC 28 Z9 28 U1 0 U2 17 PU ROYAL COLLEGE OF PSYCHIATRISTS PI LONDON PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG, ENGLAND SN 0007-1250 EI 1472-1465 J9 BRIT J PSYCHIAT JI Br. J. Psychiatry PD MAR PY 2014 VL 204 IS 3 BP 202 EP 209 DI 10.1192/bjp.bp.113.129569 PG 8 WC Psychiatry SC Psychiatry GA AD0EJ UT WOS:000332907000008 PM 24434071 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Two Harrys and "A Most Interesting Story" A Document of Note SO CIVIL WAR HISTORY LA English DT Article C1 [Rafuse, Ethan S.] US Army Command, Leavenworth, KS 66027 USA. [Rafuse, Ethan S.] Gen Staff Coll, Leavenworth, KS USA. RP Rafuse, ES (reprint author), US Army Command, Leavenworth, KS 66027 USA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 EI 1533-6271 J9 CIVIL WAR HIST JI Civil War Hist. PD MAR PY 2014 VL 60 IS 1 BP 58 EP 65 PG 8 WC History SC History GA AC8XM UT WOS:000332818400004 ER PT J AU Brown, AM Zifchock, RA Hillstrom, HJ AF Brown, Allison M. Zifchock, Rebecca A. Hillstrom, Howard J. TI The effects of limb dominance and fatigue on running biomechanics SO GAIT & POSTURE LA English DT Article DE Exertion; Kinematics; Kinetics; Limb laterality ID LOWER-EXTREMITY MECHANICS; ILIOTIBIAL BAND SYNDROME; GROUND REACTION FORCES; EXHAUSTIVE RUN; FEMALE RUNNERS; SYMMETRY; ASYMMETRY; WALKING; MOTION; ANKLE AB Purpose: To establish whether lower extremity limb dominance has an effect on overground running mechanics. Background: In attempts to resolve unilateral pathology, physical therapists often use the restoration of symmetry as a clinical milestone. While lower limb dominance has been shown to affect lower extremity mechanics during dynamic tasks such as jump landing, its effect on running gait is poorly understood. Further, despite the role of fatigue in running mechanics and injury, the interaction between fatigue and limb dominance has yet to be examined. Methods: Three-dimensional kinematic and kinetic data were collected on 20 females during overground running. Data were collected prior-to and following a treadmill run to exertion. Dominant and non-dominant limb data were compared in the fresh-state using a paired t-test. A 2-way repeated-measures ANOVA was used to test for an interaction between fatigue and limb dominance. Results: There were no significant differences between the kinematic or kinetic patterns of the dominant and non-dominant lower extremities during fresh-state overground running. Fatigue was not shown to interact with limb dominance. Conclusion: Limb dominance did not affect kinematic or kinetic side-to-side differences. Therefore, physical therapists can continue to use resolution of lower extremity symmetry as a goal of therapy without having to account for limb dominance. The lack of an interaction between fatigue and limb dominance indicates that the dominant and non-dominant limbs fatigue at a similar rate. (C) 2013 Elsevier B. V. All rights reserved. C1 [Brown, Allison M.] Dept Rehabil & Movement Sci, Rutgers Biomed & Hlth Sci, Newark, NJ USA. [Zifchock, Rebecca A.] United States Mil Acad, Dept Civil Mech Engn, West Point, NY USA. [Hillstrom, Howard J.] Hosp Special Surg, MD Mot Anal Lab, Leon Root, New York, NY 10021 USA. RP Brown, AM (reprint author), Sch Hlth Related Profess, Dept Rehabil & Movement Sci, Rutgers Biomed & Hlth Sci, 65 Bergen St,Room 714, Newark, NJ 07107 USA. EM allison.m.brown@rutgers.edu NR 18 TC 10 Z9 10 U1 3 U2 36 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 EI 1879-2219 J9 GAIT POSTURE JI Gait Posture PD MAR PY 2014 VL 39 IS 3 BP 915 EP 919 DI 10.1016/j.gaitpost.2013.12.007 PG 5 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA AD0YM UT WOS:000332960600015 PM 24405748 ER PT J AU Keller, SD Zaghloul, AI Shanov, V Schulz, MJ Mast, DB Alvarez, NT AF Keller, Steven D. Zaghloul, Amir I. Shanov, Vesselin Schulz, Mark J. Mast, David B. Alvarez, Noe T. TI Electromagnetic Simulation and Measurement of Carbon Nanotube Thread Dipole Antennas SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Carbon nanotube (CNT); dimethyl sufoxide; dipole antenna; Hallen's integral equation; method of moments ID PROPAGATION; PERFORMANCE; RADIO; YARNS AB The conductivity, current distribution, and radiation efficiency for a variety of dipole antennas constructed from carbon nanotube thread/rope are simulated using Hallen's integral equation for a thin wire applied to the method of moments and are compared to a standard copper wire dipole antenna. Next, the conductivity and weight of fully fabricated carbon nanotube thread and rope samples are measured and analyzed. Finally, half-wavelength copper and carbon nanotube (CNT) thread dipole antenna prototypes are fabricated, measured, and analyzed. Simulation results indicate that the CNT thread/rope antenna performance improves with increased diameter and that the application of these materials as a half wavelength dipole antenna yields manageable losses of less than 1-5 dB at RF frequencies above 10 GHz. Measured sample results demonstrate that the existing single-ply CNT thread exhibits a conductivity approximately 2-3 orders of magnitude lower than copper. The braiding method employed to produce large diameter CNT rope was demonstrated to be a poor method for increasing thread diameter and conductivity due to the additional resistive losses that the braiding geometry introduced. Dimethyl sulfoxide densification was found to be a valuable method for improving CNT thread conductivity and lowering the thread contact resistance. Dipole antenna prototype measurements confirm the functionality of the CNT thread as an antenna, albeit with a 4% downward frequency shift due to reactance effects and material losses of greater than 12 dB at 2.45 GHz as predicted by the results from the method of moments simulations. C1 [Keller, Steven D.; Zaghloul, Amir I.] US Army Res Lab, Adelphi, MD 20783 USA. [Shanov, Vesselin; Schulz, Mark J.; Mast, David B.; Alvarez, Noe T.] Univ Cincinnati, Cincinnati, OH 45221 USA. [Schulz, Mark J.] Gen Nano GN LLC, Adv Concepts, Cincinnati, OH 45212 USA. RP Keller, SD (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM saxman717@gmail.com; amir.i.zaghloul.civ@mail.mil; vesselin.shanov@uc.edu; mark.schulz@uc.edu; mastdb@ucmail.uc.edu; alvarene@UCMAIL.UC.EDU FU U.S. Army Research Laboratory [W911QX11P0132] FX This work was supported in part by the U.S. Army Research Laboratory under Contract W911QX11P0132. The review of this paper was arranged by Associate Editor A. Martinez. NR 21 TC 1 Z9 1 U1 1 U2 23 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X EI 1941-0085 J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD MAR PY 2014 VL 13 IS 2 BP 394 EP 403 DI 10.1109/TNANO.2014.2306330 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA AD2SC UT WOS:000333084400030 ER PT J AU Lund, BJ Rule, GT AF Lund, Brian J. Rule, Gregory T. TI Pressure Wave Dosimetry for "Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury'' SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Letter C1 [Lund, Brian J.] JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX 78234 USA. [Rule, Gregory T.] Appl Res Associates, San Antonio, TX USA. RP Lund, BJ (reprint author), JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX 78234 USA. EM brian.j.lund.civ@mail.mil NR 4 TC 2 Z9 2 U1 0 U2 5 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR PY 2014 VL 55 IS 3 BP 1348 EP 1349 DI 10.1167/iovs.13-13337 PG 2 WC Ophthalmology SC Ophthalmology GA AD2BA UT WOS:000333036500021 PM 24603600 ER PT J AU da Cruz, JD Rich, LE AF da Cruz, Jose de Arimatela Rich, Leigh E. TI Competing Imperatives? Moral and Public Health Duties of Preventing and Treating Infectious Disease in Prisons SO JOURNAL OF BIOETHICAL INQUIRY LA English DT Article DE Prisoners; Infectious disease; Risk; Research ethics; Public health; Duty of care ID HIV-INFECTION; SAO-PAULO; INMATES; TUBERCULOSIS; TRANSMISSION; PENITENTIARY; PREVALENCE; BRAZIL; STATE C1 [da Cruz, Jose de Arimatela] US Army War Coll, Carlisle, PA 17013 USA. [da Cruz, Jose de Arimatela] Armstrong Atlantic State Univ, Dept Criminal Justice Social & Polit Sci, Savannah, GA 31419 USA. [Rich, Leigh E.] Armstrong Atlantic State Univ, Dept Hlth Sci Publ Hlth, Savannah, GA 31419 USA. RP Rich, LE (reprint author), Armstrong Atlantic State Univ, Dept Hlth Sci Publ Hlth, 11935 Abercorn St,Univ Hall 154F, Savannah, GA 31419 USA. EM jose.dacruz@armstrong.edu; leigh.rich@armstrong.edu NR 19 TC 1 Z9 1 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1176-7529 EI 1872-4353 J9 J BIOETHIC INQ JI J. Bioethical Inq. PD MAR PY 2014 VL 11 IS 1 BP 105 EP 108 DI 10.1007/s11673-014-9508-5 PG 4 WC Ethics; Medical Ethics; Social Issues; Social Sciences, Biomedical SC Social Sciences - Other Topics; Medical Ethics; Social Issues; Biomedical Social Sciences GA AD4FB UT WOS:000333202000017 ER PT J AU Takhampunya, R Kim, HC Tippayachai, B Lee, DK Lee, WJ Chong, ST Kim, MS Lee, JS Klein, TA AF Takhampunya, Ratree Kim, Heung Chul Tippayachai, Bousaraporn Lee, Dong-Kyu Lee, Won-Ja Chong, Sung-Tae Kim, Myung Soon Lee, John S. Klein, Terry A. TI Distribution and Mosquito Hosts of Chaoyang Virus, a Newly Reported Flavivirus From the Republic of Korea, 2008-2011 SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE insect-specific flavivirus; Chaoyang virus; Aedes vexans nipponii; Republic of Korea ID JAPANESE ENCEPHALITIS-VIRUS; DIPTERA-CULICIDAE; PHYLOGENETIC-RELATIONSHIPS; SEASONAL PREVALENCE; DEMILITARIZED ZONE; GENUS FLAVIVIRUS; MAINLAND CHINA; LIGHT TRAPS; TRANSMISSION; SURVEILLANCE AB In total, 183,602 female culicine mosquitoes were captured by Mosquito Magnet, black light, and New Jersey light traps, and manual aspiration of resting blood-fed mosquitoes, in the Republic of Korea from 2008 to 2011. Culicine mosquitoes were identified to species, placed in pools of up to 30 mosquitoes each, and screened for flavivirus RNA by using an SYBR green I-based reverse transcription-polymerase chain reaction assay. Thirty-two of the 8,199 pools assayed were positive by quantitative polymerase chain reaction for Chaoyang virus (CHAOV), an insect-specific virus [26 Aedes vexans nipponii Theobald, 3 Culex pipiens L., 1 Aedes albopictus (Skuse), 1 Aedes bekkui Mogi, and 1 Armigeres subalbatus (Coquillett)]. The maximum likelihood estimations (estimated number of virus-positive mosquitoes/1,000 mosquitoes) for Ae. bekkui, Ae. albopictus, Ar. subalbatus, Ae. vexans nipponii, and Cx. pipiens positive for CHAOV were 5.37, 3.29, 0.77, 0.27, and 0.26, respectively. CHAOV is an insect-specific virus, and there is currently no evidence to suggest a role in animal or human disease. C1 [Takhampunya, Ratree; Tippayachai, Bousaraporn] Armed Forces Res Inst Med Sci, Diagnost & Reemerging Infect Dis Sect, Dept Entomol, Bangkok 10400, Thailand. [Kim, Heung Chul; Chong, Sung-Tae; Kim, Myung Soon] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, APO, AP 96205 USA. [Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea. [Lee, Won-Ja] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, Natl Inst Hlth, Cheongwon Gun 363951, Chungbuk Provin, South Korea. [Lee, John S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Klein, Terry A.] US Army Publ Hlth Command Reg Pacific, Camp Zama, Japan. RP Klein, TA (reprint author), US Army Publ Hlth Command Reg Pacific, Camp Zama, Japan. EM terry.a.klein2.civ@mail.mil FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSCDGEIS); National Center for Medical Intelligence; Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK; AFRIMS; U. S. Army Public Health Command Region-Pacific, Camp Zama, Japan; Medical Brigade, U. S. Army Garrison, Yongsan, Seoul, Korea FX We thank COL Hee-Choon S. Lee, Chief, Force Health Protection and Preventive Medicine, 65th Medical Brigade, for his support. Special thanks go to CPT Adam R. Irby, ILT Christopher A. Taylor, and U. S. Army soldiers at the Joint Security Area for their support and assistance in mosquito collections. We thank LTC Anthony Schuster, AFRIMS, for his technical review and support, and Achareeya Korkusol and Sommai Promstaporn, AFRIMS, for their laboratory support in the development of primer design, sequencing, and RNA extraction. We also thank MG Jean-Jacques Joss, MG Urs Gerber, MG Christer Lisdtrom, and RAD Anders Gren-stad of the NNSC and their staff for their support for conducting vector-borne disease surveillance at theNNSCcamp near the military demarcation line inside the DMZ. We sincerely thank LTC Brian Evans, Public Health Command Region-Pacific, for his support and critical review of the manuscript. Funding and support for this work was provided by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSCDGEIS), Silver Spring, MD; the National Center for Medical Intelligence; the Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK; AFRIMS; the U. S. Army Public Health Command Region-Pacific, Camp Zama, Japan; and the 65th Medical Brigade, U. S. Army Garrison, Yongsan, Seoul, Korea. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army, the Department of Defense, or the Korean National Institute of Health. NR 46 TC 4 Z9 4 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 2014 VL 51 IS 2 BP 464 EP 474 DI 10.1603/ME13033 PG 11 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AC5CW UT WOS:000332539500021 PM 24724298 ER PT J AU Gupta, N Voloshinov, V AF Gupta, Neelam Voloshinov, Vitaly TI Spectral characterization in deep UV of an improved imaging KDP acousto-optic tunable filter SO JOURNAL OF OPTICS LA English DT Article DE acousto-optic tunable filter; ultraviolet; KDP; hyperspectral; imaging ID ULTRAVIOLET; IMAGER; PERFORMANCE; CRYSTALS AB Recently, we developed a number of high quality noncollinear acousto-optic tunable filter (AOTF) cells in different birefringent materials with UV imaging capability. Cells based on a single crystal of KDP (potassium dihydrophosphate) had the best transmission efficiency and the optical throughput needed to acquire high quality spectral images at wavelengths above 220 nm. One of the main limitations of these imaging filters was their small angular aperture in air, limited to about 1.0 degrees. In this paper, we describe an improved imaging KDP AOTF operating from the deep UV to the visible region of the spectrum. The linear and angular apertures of the new filter are 10 x 10 mm(2) and 1.8 degrees, respectively. The spectral tuning range is 205-430 nm with a 60 cm(-1) spectral resolution. We describe the filter and present experimental results on imaging using both a broadband source and a number of light emitting diodes (LEDs) in the UV, and include the measured spectra of these LEDs obtained with a collinear SiO2 filter-based spectrometer operating above 255 nm. C1 [Gupta, Neelam] US Army Res Lab, Adelphi, MD 20783 USA. [Voloshinov, Vitaly] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. RP Gupta, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM neelam.gupta.civ@mail.mil NR 38 TC 7 Z9 7 U1 0 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 EI 2040-8986 J9 J OPTICS-UK JI J. Opt. PD MAR PY 2014 VL 16 IS 3 AR 035301 DI 10.1088/2040-8978/16/3/035301 PG 9 WC Optics SC Optics GA AC8CM UT WOS:000332760600014 ER PT J AU Garrison, M Westrick, RB Johnson, MR AF Garrison, Michael Westrick, Richard B. Johnson, Michael R. TI Morel-Lavallee Lesion of the Lumbar Region SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Garrison, Michael; Westrick, Richard B.; Johnson, Michael R.] US Mil Acad, Keller Army Community Hosp, West Point, NY 10996 USA. RP Garrison, M (reprint author), US Mil Acad, Keller Army Community Hosp, West Point, NY 10996 USA. NR 3 TC 3 Z9 3 U1 0 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 2014 VL 44 IS 3 BP 223 EP 223 DI 10.2519/jospt.2014.0404 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AD3LC UT WOS:000333139600011 PM 24579797 ER PT J AU Phasomkusolsil, S Kim, HC Pantuwattana, K Tawong, J Khongtak, W Schuster, AL Klein, TA AF Phasomkusolsil, Siriporn Kim, Heung-Chul Pantuwattana, Kanchana Tawong, Jaruwan Khongtak, Weeraphan Schuster, Anthony L. Klein, Terry A. TI COLONIZATION AND MAINTENANCE OF ANOPHELES KLEINI AND ANOPHELES SINENSIS FROM THE REPUBLIC OF KOREA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Anopheles kleini; An. sinensis; colonization; Republic of Korea ID PLASMODIUM-VIVAX; SPECIES COMPOSITION; HYRCANUS GROUP; LARVAL HABITATS; SOUTH-KOREA; US FORCES; MALARIA; CULICIDAE; DIPTERA; MOSQUITOS AB Colonization of members of the Anopheles Hyrcanus Group is required to facilitate a better understanding of their roles in the epidemiology, vector competence, transmission potential, and maintenance of vivax malaria in the Republic of Korea (ROK). A total of 158 resting blood-fed wild caught Anopheles species were collected on August 26, 2011 at Tongilchon, near the demilitarized zone, in the ROK and shipped on August 28, 2011 to the Entomology Department, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand. Four of the 5 species of the Anopheles Hyrcanus Group (Anopheles kleini, An. sinensis, An. pullus, and An. belenrae) were identified by polymerase chain reaction. Eggs were obtained from parent populations, and F-1 progeny provided blood meals using membrane feeding techniques. The mean numbers of eggs/female for An. sinensis and An. kleini were 157 and 146, respectively. Membrane blood feeding rates for An. sinensis (90.6%) and An. kleini (89.0%) were similar for F-1-F-30 generations. Colonies of An. kleini and An. sinensis were established by force mating techniques and maintained by the Insectary Section, Entomology Department, AFRIMS, to date. This is the 1st report of successful laboratory colonization of An. kleini collected from a vivax malaria high-risk area in the ROK. C1 [Phasomkusolsil, Siriporn; Pantuwattana, Kanchana; Tawong, Jaruwan; Khongtak, Weeraphan; Schuster, Anthony L.] US Army Med Componenet, Dept Entomol, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Kim, Heung-Chul] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA. [Klein, Terry A.] 65th Med Brigade, Publ Hlth Command Reg Pacific, Camp Zama, Unit 15281, APO, AP 96205 USA. RP Klein, TA (reprint author), 65th Med Brigade, Publ Hlth Command Reg Pacific, Camp Zama, Unit 15281, APO, AP 96205 USA. FU AFHSC-GEIS, Silver Spring, MD FX We thank Joel Gaydos and Jeffrey McCollum, Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, for their administrative and technical support. We thank James Jones, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand, for his editorial assistance. We also wish to express our gratitude to Alongkot Ponlawat and his team, Ratree Takhampunya and her team, and the Insectary staff at AFRIMS for providing technical support. Funding for this work was provided by the AFHSC-GEIS, Silver Spring, MD. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 39 TC 2 Z9 2 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2014 VL 30 IS 1 BP 1 EP 6 DI 10.2987/13-6390.1 PG 6 WC Entomology SC Entomology GA AC8NI UT WOS:000332789500001 PM 24772671 ER PT J AU Kim, HC Kim, MS Chong, ST Park, JY Rueda, LM Klein, TA AF Kim, Heung-Chul Kim, Myung-Soon Chong, Sung-Tae Park, Jee-Yong Rueda, Leopoldo M. Klein, Terry A. TI FIRST COLLECTION RECORDS OF CULISETA (CULICELLA) NIPPONICA IN THE REPUBLIC OF KOREA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Culiseta nipponica; mosquitoes; Culicidae; Diptera; Republic of Korea ID MOSQUITOS DIPTERA; CULICIDAE AB The 1st confirmed record of Culiseta nipponica for the Republic of Korea was made at Osan Air Base and Tongilchon, Gyeonggi Province, and at the Incheon International Airport, Incheon metropolitan area, using carbon dioxide-baited light and Mosquito Magnet (R) traps. Larval surveys near adult collection sites during June and August 2013 were negative for Culiseta nipponica. C1 [Kim, Heung-Chul; Chong, Sung-Tae] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA. [Kim, Myung-Soon; Park, Jee-Yong] Anim & Plant Quarantine Agcy, Foreign Anim Dis Div, Anyang Si 430757, Gyeonggi Provin, South Korea. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD 20910 USA. [Klein, Terry A.] 65th Med Brigade, Publ Hlth Command Reg Pacific, Camp Zama, Unit 15281, APO, AP 96205 USA. RP Klein, TA (reprint author), 65th Med Brigade, Publ Hlth Command Reg Pacific, Camp Zama, Unit 15281, APO, AP 96205 USA. FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, MD; National Center for Medical Intelligence, Fort Detrick, MD; Public Health Command Region-Pacific, Camp Zama, Japan; Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi Province, ROK FX We thank the commander and soldiers of the 5th Medical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade, for their assistance in conducting mosquito-borne disease surveillance. We also thank Christopher Taylor and Steve Roper and their medical staff, United Nations Command Support Battalion, Camp Bonifas, for their assistance and coordination for mosquito collections at the Neutral Nations Supervisory Camp and Daeseongdong, and the staff of the Incheon International Airport Regional Office, Animal and Plant Quarantine Agency for their assistance and coordination for the collection of mosquitoes. Funding for this research was provided by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, MD; the National Center for Medical Intelligence, Fort Detrick, MD; the Public Health Command Region-Pacific, Camp Zama, Japan; and the Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi Province, ROK. The opinions expressed herein are those of the authors and are not to be construed as official or reflecting the views of the US Department of the Army, Department of Defense, or the US Government. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2014 VL 30 IS 1 BP 54 EP 56 PG 3 WC Entomology SC Entomology GA AC8NI UT WOS:000332789500008 PM 24772678 ER PT J AU Miranda, LE Killgore, KJ AF Miranda, L. E. Killgore, K. J. TI FISH DEPTH DISTRIBUTIONS IN THE LOWER MISSISSIPPI RIVER SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE depth distribution; Mississippi River; fish assemblage; trotline ID PERCH PERCA-FLUVIATILIS; CORAL-REEF FISH; BODY-SIZE; LAKE-MICHIGAN; SPECIES RICHNESS; ASSEMBLAGES; GRADIENT; PATTERNS; LONGLINE; HABITAT AB A substantial body of literature exists about depth distribution of fish in oceans, lakes and reservoirs, but less is known about fish depth distribution in large rivers. Most of the emphasis on fish distributions in rivers has focused on longitudinal and latitudinal spatial distributions. Knowledge on depth distribution is necessary to understand species and community habitat needs. Considering this void, our goal was to identify patterns in fish benthic distribution along depth gradients in the Lower Mississippi River. Fish were collected over 14years in depths down to 27m. Fish exhibited non-random depth distributions that varied seasonally and according to species. Species richness was highest in shallow water, with about 50% of the 62 species detected no longer collected in water deeper than 8m and about 75% no longer collected in water deeper than 12m. Although richness was highest in shallow water, most species were not restricted to shallow water. Rather, most species used a wide range of depths. A weak depth zonation occurred, not as strong as that reported for deep oceans and lakes. Larger fish tended to occur in deeper water during the high-water period of an annual cycle, but no correlation was evident during the low-water period. The advent of landscape ecology has guided river research to search for spatial patterns along the length of the river and associated floodplains. Our results suggest that fish assemblages in large rivers are also structured vertically. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA. [Killgore, K. J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Box 9691, Mississippi State, MS 39762 USA. EM smiranda@usgs.gov FU Mississippi Valley Division of the US Army Corps of Engineers; Ecosystem Management and Restoration Research Program FX Funding for data collection was provided by the Mississippi Valley Division of the US Army Corps of Engineers and the Ecosystem Management and Restoration Research Program. Additional funding for data analyses was provided by Free-Flow Power, Boston. Assistance in field collections was provided by S. George, W. Lancaster, B. Lewis, P. Kirk, C. Murphy, N. Douglas, K. Boysen and J. Collins. Permission to publish this document was made by the Chief of Engineers, US Army Corps of Engineers. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U. S. Government. NR 60 TC 0 Z9 1 U1 2 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAR PY 2014 VL 30 IS 3 BP 347 EP 359 DI 10.1002/rra.2652 PG 13 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AD1YF UT WOS:000333028900007 ER PT J AU Walsh, DV Liu, L AF Walsh, David V. Liu, Lei TI Adaptation to a simulated central scotoma during visual search training SO VISION RESEARCH LA English DT Article DE Low vision; Central scotoma; Visual search; Adaptation; Eye movements; Simulation ID PREFERRED RETINAL LOCI; LOW-VISION PATIENTS; EYE-MOVEMENTS; MACULAR DEGENERATION; ECCENTRIC FIXATION; FIELD ASYMMETRIES; ATTENTION; DISEASE; FOVEA; PATTERNS AB Patients with a central scotoma usually use a preferred retinal locus (PRL) consistently in daily activities. The selection process and time course of the PRL development are not well understood. We used a gaze-contingent display to simulate an isotropic central scotoma in normal subjects while they were practicing a difficult visual search task. As compared to foveal search, initial exposure to the simulated scotoma resulted in prolonged search reaction time, many more fixations and unorganized eye movements during search. By the end of a 1782-trial training with the simulated scotoma, the search performance improved to within 25% of normal foveal search. Accompanying the performance improvement, there were also fewer fixations, fewer repeated fixations in the same area of the search stimulus and a clear tendency of using one area near the border of the scotoma to identify the search target. The results were discussed in relation to natural development of PRL in central scotoma patients and potential visual training protocols to facilitate PRL development. Published by Elsevier Ltd. C1 [Walsh, David V.; Liu, Lei] Univ Alabama Birmingham, Sch Optometry, Birmingham, AL 35294 USA. [Walsh, David V.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Walsh, DV (reprint author), US Army Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM david.v.walsh.mil@mail.mil FU United States Army's Long Term Health Education and Training (LTHET) FX The first author would like to acknowledge the support from the United States Army's Long Term Health Education and Training (LTHET) program. Without this support, the study could not have been completed. NR 64 TC 8 Z9 8 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0042-6989 EI 1878-5646 J9 VISION RES JI Vision Res. PD MAR PY 2014 VL 96 BP 75 EP 86 DI 10.1016/j.visres.2014.01.005 PG 12 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA AC4NJ UT WOS:000332497700010 PM 24456805 ER PT J AU Chursi, S Siripaitoon, P Silpapojakul, K Hortiwakul, T Charernmak, B Chinnawirotpisan, P Nisalak, A Thaisomboonsuk, B Klungthong, C Gibbons, RV Jarman, RG AF Chursi, Sarunyou Siripaitoon, Pisud Silpapojakul, Kachornsak Hortiwakul, Thanaporn Charernmak, Boonsri Chinnawirotpisan, Piyawan Nisalak, Ananda Thaisomboonsuk, Butsaya Klungthong, Chonticha Gibbons, Robert V. Jarman, Richard G. TI Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008-2009 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ARTHROPOD-BORNE VIRUSES; REUNION ISLAND; GENOME CHARACTERIZATION; LABORATORY FEATURES; INDIAN-OCEAN; FEVER; HEMAGGLUTINATION; REEMERGENCE; ARTHRALGIA; SINGAPORE AB The Indian Ocean chikungunya epidemic re-emerged in Thailand in August 2008. Forty-five adults with laboratory-confirmed chikungunya in Songkhla province, Thailand were clinically assessed and serially bled throughout the acute and convalescent phase of the disease. Patient symptoms, antibody responses, and viral kinetics were evaluated using observational assessments, polymerase chain reaction (PCR), and serological assays. All subjects experienced joint pain with 42 (93%) involving multiple joints; the interphalangeal most commonly affected in 91% of the subjects. The mean duration of joint pain was 5.8 days, 11(25%) experiencing discomfort through the duration of the study. Rash was observed in 37 (82%) subjects a mean 3.5 days post onset of symptoms. Patents were positive by PCR for a mean of 5.9 days with sustained peak viral load through Day 5. The IgM antibodies appeared on Day 4 and peaked at Day 7 and IgG antibodies first appeared at Day 5 and rose steadily through Day 24. C1 Prince Songkla Univ, Div Infect Dis, Dept Internal Med, Fac Med, Hat Yai, Thailand. Armed Forces Res Inst Medial Sci, Dept Virol, Bangkok, Thailand. [Chursi, Sarunyou; Siripaitoon, Pisud; Silpapojakul, Kachornsak; Hortiwakul, Thanaporn; Charernmak, Boonsri] Prince Songkla Univ, Div Infect Dis, Dept Internal Med, Fac Med, Hat Yai Dist, Songkla Provinc, Thailand. [Chinnawirotpisan, Piyawan; Nisalak, Ananda; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Gibbons, Robert V.; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Jarman, RG (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Sarunyouchursri@hotmail.com; spisud@medicine.psu.ac.th; skhachor@medicine.psu.ac.th; hratree@medicine.psu.ac.th; cboonsri@medicine.psu.ac.th; PiyawanC@afrims.org; AnandaN@afrims.org; ButsayaT@afrims.org; ChontichaK@afrims.org; Robert.gibbons@afrims.org; rick.jarman@us.army.mil FU Faculty of Medicine, Prince of Songkhla University; U.S. Department of State Bioengagement Program; Global Emerging Infection System a Division of the Armed Forces Health Surveillance Center FX Funding for this work provided by the Faculty of Medicine, Prince of Songkhla University and laboratory support was funded in part by the U.S. Department of State Bioengagement Program and the Global Emerging Infection System a Division of the Armed Forces Health Surveillance Center. NR 45 TC 1 Z9 1 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2014 VL 90 IS 3 BP 410 EP 417 DI 10.4269/ajtmh.12-0681 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AC2RY UT WOS:000332352900005 ER PT J AU Haynes, MA Kung, KJS Brandt, JS Yang, YP Waller, DM AF Haynes, Michelle A. Kung, King-Jau Samuel Brandt, Jodi S. Yang Yongping Waller, Donald M. TI Accelerated climate change and its potential impact on Yak herding livelihoods in the eastern Tibetan plateau SO CLIMATIC CHANGE LA English DT Article ID SUMMER TEMPERATURE; NORTHWEST YUNNAN; CHINA; VARIABILITY; BIODIVERSITY; PRECIPITATION; PHENOLOGY; WINTER AB The Tibetan Plateau has experienced rapid warming like most other alpine regions. Regional assessments show rates of warming comparable with the arctic region and decreasing Asian summer monsoons. We used meteorological station daily precipitation and daily maximum and minimum temperature data from 80 stations in the eastern Tibetan Plateau of southwest China to calculate local variation in the rates and seasonality of change over the last half century (1960-2008). Daily low temperatures during the growing season have increased greatly over the last 24 years (1984-2008). In sites of markedly increased warming (e.g., Deqin, Yunnan and Mangya, Qinghai), daily and growing season daily high temperatures have increased at a rate above 5 A degrees C/100 years. In Deqin, precipitation prior to the 1980s fell as snow whereas in recent decades it has shifted to rain during March and April. These shifts to early spring rains are likely to affect plant communities. Animals like yaks adapted to cold climates are also expected to show impacts with these rising temperatures. This region deserves further investigation to determine how these shifts in climate are affecting local biodiversity and livelihoods. C1 [Haynes, Michelle A.; Waller, Donald M.] Univ Wisconsin, Dept Bot, Madison, WI 53706 USA. [Kung, King-Jau Samuel] Univ Wisconsin, Dept Soil Sci, Madison, WI 53706 USA. [Brandt, Jodi S.] Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA. [Yang Yongping] Chinese Acad Sci, Inst Tibetan Plateau Res, Beijing 100085, Peoples R China. RP Haynes, MA (reprint author), US Army Corps Engineers, Inst Water Resources, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM michelleahaynes@gmail.com FU National Science Foundation [DGE-0549369 IGERT] FX This material is based upon work supported by the National Science Foundation under Grant No. DGE-0549369 IGERT: Training Program on Biodiversity Conservation and Sustainable Development in Southwest China at the University of Wisconsin-Madison. We thank graduate students at Kunming Institute of Botany and staff at the Shangri-la Alpine Botanical Garden for their assistance. We would also like to thank two anonymous reviewers for their contribution. NR 44 TC 6 Z9 6 U1 2 U2 41 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD MAR PY 2014 VL 123 IS 2 BP 147 EP 160 DI 10.1007/s10584-013-1043-6 PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AC6SW UT WOS:000332656100006 ER PT J AU Frank, LN AF Frank, Lucas N. TI Playing with Fire: Woodrow Wilson, Self-Determination, Democracy, and Revolution in Mexico SO HISTORIAN LA English DT Article C1 [Frank, Lucas N.] US Mil Acad, West Point, NY USA. NR 79 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0018-2370 EI 1540-6563 J9 HISTORIAN JI Historian PD SPR PY 2014 VL 76 IS 1 BP 71 EP 96 DI 10.1111/hisn.12028 PG 26 WC History SC History GA AC0FU UT WOS:000332171000004 ER PT J AU Fu, Q Nasiri, A Bhavaraju, V Solanki, A Abdallah, T Yu, DC AF Fu, Qiang Nasiri, Adel Bhavaraju, Vijay Solanki, Ashish Abdallah, Tarek Yu, David C. TI Transition Management of Microgrids With High Penetration of Renewable Energy SO IEEE TRANSACTIONS ON SMART GRID LA English DT Article DE Control; islanding; microgrid; transients; transition ID STORAGE AB Microgrids are receiving attention due to the increasing need to integrate distributed generations and to ensure power quality and to provide energy surety to critical loads. Some of the main topics concerning microgrids are transients and stability concerns during transitions including intentional and unintentional islanding and reconnection. In this paper, the standard IEEE 34 bus distribution feeder is adapted and managed as a microgrid by adding distributed generations and load profiles. Supervisory power managements have been defined to manage the transitions and to minimize the transients on voltage and frequency. Detailed analyses for islanding, reconnection, and black start are presented for various conditions. The proposed control techniques accept inputs from local measurements and supervisory controls in order to manage the system voltage and frequency. An experimental system has been built which includes three 250 kW inverters emulating natural gas generator, energy storage, and renewable source. The simulation and experimental results are provided which verifies the analytical presentation of the hardware and control algorithms. C1 [Fu, Qiang; Bhavaraju, Vijay] Eaton Global Res & Technol, Menomonee Falls, WI 53051 USA. [Nasiri, Adel; Solanki, Ashish; Yu, David C.] Univ Wisconsin, Milwaukee, WI 53201 USA. [Abdallah, Tarek] US Army, Champaign, IL 61822 USA. RP Fu, Q (reprint author), Eaton Global Res & Technol, Menomonee Falls, WI 53051 USA. EM qiangfu2@eaton.com; nasiri@uwm.edu; tarek.abdallah@erdc.usace.army.mil FU U.S. Army Corps of Engineers (ERDC/CERL) [W9132T-11-C-0022] FX This work was supported in part by the U.S. Army Corps of Engineers (ERDC/CERL) under Contract No. W9132T-11-C-0022. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. Army Corps of Engineers. Paper TSG-00030-2013. NR 18 TC 14 Z9 14 U1 3 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-3053 J9 IEEE T SMART GRID JI IEEE Trans. Smart Grid PD MAR PY 2014 VL 5 IS 2 BP 539 EP 549 DI 10.1109/TSG.2013.2286952 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA AB7QH UT WOS:000331985300001 ER PT J AU Eakle, WL Lishka, JJ Kirven, MN Hawley, J AF Eakle, Wade L. Lishka, Joseph J. Kirven, Monte N. Hawley, John TI COOPERATIVE KLEPTOPARASITISM BY A PAIR OF BALD EAGLES AT LAKE SONOMA, CALIFORNIA SO JOURNAL OF RAPTOR RESEARCH LA English DT Letter DE Bald Eagle; Haliaeetus leucocephalus; Osprey; Pandion haliaetus; cooperative hunting; kleptoparasitism C1 [Eakle, Wade L.] US Army Corps Engineers, South Pacific Div, San Francisco, CA 94103 USA. [Lishka, Joseph J.] US Army Corps Engineers, Geyserville, CA 95446 USA. [Kirven, Monte N.] Kirven Associates Biol Consultants, Santa Rosa, CA 95404 USA. [Hawley, John] Hawley Winery & Vineyards, Healdsburg, CA 95448 USA. RP Eakle, WL (reprint author), US Army Corps Engineers, South Pacific Div, 1455 Market St, San Francisco, CA 94103 USA. EM Wade.L.Eakle@usace.army.mil NR 22 TC 0 Z9 0 U1 1 U2 15 PU RAPTOR RESEARCH FOUNDATION INC PI HASTINGS PA 14377 117TH STREET SOUTH, HASTINGS, MN 55033 USA SN 0892-1016 EI 2162-4569 J9 J RAPTOR RES JI J. Raptor Res. PD MAR PY 2014 VL 48 IS 1 BP 89 EP 91 PG 3 WC Ornithology SC Zoology GA AC7YQ UT WOS:000332750600013 ER PT J AU Scisco, JL Muth, ER Hoover, AW AF Scisco, Jenna L. Muth, Eric R. Hoover, Adam W. TI Examining the Utility of a Bite-Count-Based Measure of Eating Activity in Free-Living Human Beings SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Bites; Ambulatory Monitoring; Eating activity; Energy intake; Free-living humans ID ENERGY-INTAKE; FOOD-INTAKE; DIETARY; BEHAVIOR AB The obesity epidemic has triggered a need for novel methods for measuring eating activity in free-living settings. Here, we introduce a bite-count method that has the potential to be used in long-term investigations of eating activity. The purpose of our observational study was to describe the relationship between bite count and energy intake and determine whether there are sex and body mass index group differences in kilocalories per bite in free-living human beings. From October 2011 to February 2012, 77 participants used a wrist-worn device for 2 weeks to measure bite count during 2,975 eating activities. An automated self-administered 24-hour recall was completed daily to provide kilocalorie estimates for each eating activity. Pearson's correlation indicated a moderate, positive correlation between bite count and kilocalories (r=0.44; P<0.001) across all 2,975 eating activities. The average per-individual correlation was 0.53. A 2 (sex)x3 (body mass index group: normal, overweight, obese) analysis of variance indicated that men consumed 6 kcal more per bite than women on average. However, there were no body mass index group differences in kilocalories per bite. This was the longest study of a body-worn sensor for monitoring eating activity of free-living human beings to date, which highlights the strong potential for this method to be used in future, long-term investigations. C1 [Scisco, Jenna L.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Scisco, Jenna L.; Muth, Eric R.] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. [Muth, Eric R.] Clemson Univ, Dept Psychol, Human Factors Inst, Clemson, SC 29634 USA. [Hoover, Adam W.] Clemson Univ, Dept Elect & Comp Engn, Clemson, SC 29634 USA. RP Muth, ER (reprint author), Clemson Univ, Dept Psychol, 418 Brackett Hall, Clemson, SC 29634 USA. EM muth@clemson.edu FU Science, Mathematics, and Research for Transformation scholarship; Clemson University Creative Inquiry grant FX J. L. Scisco was supported by a Science, Mathematics, and Research for Transformation scholarship. Funding for some study materials was provided by a Clemson University Creative Inquiry grant. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the-Army endorsement of approval of the products or services of these organizations. NR 20 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 EI 2212-2680 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD MAR PY 2014 VL 114 IS 3 BP 464 EP 469 DI 10.1016/j.jand.2013.09.017 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AC4OR UT WOS:000332501100016 PM 24231364 ER PT J AU Belenkiy, SM Buel, AR Cannon, JW Sine, CR Aden, JK Henderson, JL Liu, NT Lundy, JB Renz, EM Batchinsky, AI Cancio, LC Chung, KK AF Belenkiy, Slava M. Buel, Allison R. Cannon, Jeremy W. Sine, Christy R. Aden, James K. Henderson, Jonathan L. Liu, Nehemiah T. Lundy, Jonathan B. Renz, Evan M. Batchinsky, Andriy I. Cancio, Leopoldo C. Chung, Kevin K. TI Acute respiratory distress syndrome in wartime military burns: Application of the Berlin criteria SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Mechanical ventilation; adult respiratory distress syndrome; the Berlin definition; combat casualty care; burns ID OPERATION IRAQI FREEDOM; ACUTE LUNG INJURY; MULTIPLE ORGAN FAILURE; FRESH-FROZEN PLASMA; INHALATION INJURY; HIGHER RISK; DEFINITION; CASUALTIES; SUPPORT; ARDS AB BACKGROUND Acute respiratory distress syndrome (ARDS) prevalence and related outcomes in burned military casualties from Iraq and Afghanistan have not been described previously. The objective of this article was to report ARDS prevalence and its associated in-hospital mortality in military burn patients. METHODS Demographic and physiologic data were collected retrospectively on mechanically ventilated military casualties admitted to our burn intensive care unit from January 2003 to December 2011. Patients with ARDS were identified in accordance with the new Berlin definition of ARDS. Subjects were categorized as having mild, moderate, or severe ARDS. Multivariate logistic regression identified independent risk factors for developing moderate-to-severe ARDS. The main outcome measure was the prevalence of ARDS in a cohort of patients burned as a result of recent combat operations. RESULTS A total of 876 burned military casualties presented during the study period, of whom 291 (33.2%) required mechanical ventilation. Prevalence of ARDS in this cohort was 32.6%, with a crude overall mortality of 16.5%. Mortality increased significantly with ARDS severity: mild (11.1%), moderate (36.1%), and severe (43.8%) compared with no ARDS (8.7%) (p < 0.001). Predictors for the development of moderate or severe ARDS were inhalation injury (odds ratio [OR], 1.90; 95% confidence interval [CI], 1.01-3.54; p = 0.046), Injury Severity Score (ISS) (OR, 1.04; 95% CI, 1.01-1.07; p = 0.0021), pneumonia (OR, 198; 95% CI, 1.07-3.66; p = 0.03), and transfusion of fresh frozen plasma (OR, 1.32; 95% CI, 1.01-1.72; p = 0.04). Size of burn was associated with moderate or severe ARDS by univariate analysis but was not an independent predictor of ARDS by multivariate logistic regression (p > 0.05). Age, size of burn, and moderate or severe ARDS were independent predictors of mortality. CONCLUSION In this cohort of military casualties with thermal injuries, nearly a third required mechanical ventilation; of those, nearly one third developed ARDS, and nearly one third of patients with ARDS did not survive. Moderate and severe ARDS increased the odds of death by more than fourfold and ninefold, respectively. LEVEL OF EVIDENCE Epidemiologic/prognostic study, level III. C1 [Belenkiy, Slava M.; Buel, Allison R.; Cannon, Jeremy W.; Sine, Christy R.; Henderson, Jonathan L.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Belenkiy, Slava M.; Aden, James K.; Liu, Nehemiah T.; Lundy, Jonathan B.; Renz, Evan M.; Batchinsky, Andriy I.; Cancio, Leopoldo C.; Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX 78234 USA. [Cannon, Jeremy W.; Renz, Evan M.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chung, KK (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM kevin.k.chung.mil@mail.mil FU Clinical Trials Task Area and Comprehensive Intensive Care Research Task Area, US Army Institute of Surgical Research, Fort Sam Houston, Texas FX This study was supported by the Clinical Trials Task Area and Comprehensive Intensive Care Research Task Area, US Army Institute of Surgical Research, Fort Sam Houston, Texas. The authors have no conflicts of interest to declare. NR 33 TC 14 Z9 15 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2014 VL 76 IS 3 BP 821 EP 827 DI 10.1097/TA.0b013e3182aa2d21 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AB8YW UT WOS:000332077100051 PM 24553555 ER PT J AU Edwards, MJ Lustik, M Carlson, T Tabak, B Farmer, D Edwards, K Eichelberger, M AF Edwards, Mary J. Lustik, Michael Carlson, Terri Tabak, Benjamin Farmer, Douglas Edwards, Kurt Eichelberger, Martin TI Surgical interventions for pediatric blast injury: An analysis from Afghanistan and Iraq 2002 to 2010 SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Pediatric; blast; treatment; explosion; surgery ID CHILDREN AB BACKGROUND Acute blast injury requires aggressive operative intervention. This study documents therapeutic procedures required for children with blast injury in Afghanistan and Iraq from 2002 to 2010 at US military treatment facilities, to understand pediatric operative resources required after explosions. METHODS The Joint Theatre Trauma Registry provides data for the previously mentioned population. The data were stratified by years of age as follows: 0 to 3, 4 to 8, 9 to 14, 15 to 19, older than 19 years. Therapeutic procedures were defined by DRG International Classification of Diseases9th Rev. codes 0 to 86.99. These were analyzed by age, body region, and Abbreviated Injury Scale (AIS) score. RESULTS A total of 5,026 patients with a known age requiring a total of 22,677 therapeutic procedures were analyzed; 25% (n = 1,205) were children 14 years or younger. On average, 4.5 procedures were required per patient and varied significantly by age. Soft tissue debridement, vascular access procedure, laparotomy, and thoracostomy were the most common procedures for all ages. For all body regions, severe injury (AIS score 3) was associated with an increased need for an invasive procedure (30-90%) in that region. Children 9 years to 14 years of age underwent significantly more procedures on average (5 procedures per patient) compared with adults (4.5 procedures per patient); children 3 years and younger underwent significantly less (3.15 procedures per patient). Children 4 years to 14 years of age were more likely than older patients to undergo a procedure for a severe head injury (40% vs. 29%), and those 9 years to 14 years old were more likely to undergo a procedure for severe thoracic injury (72%). After 4 years of age, procedures trend away from the head toward the extremity and amputation. CONCLUSION Blast-injured children require significant operative resources during the acute phase of injury. In the event of an explosive attack, pediatric operative resources and expertise are required. LEVEL OF EVIDENCE Epidemiologic study, level III. C1 [Edwards, Mary J.; Carlson, Terri; Tabak, Benjamin; Farmer, Douglas; Edwards, Kurt; Eichelberger, Martin] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Edwards, MJ (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM mary.j.edwards@us.army.mil NR 11 TC 4 Z9 5 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2014 VL 76 IS 3 BP 854 EP 858 DI 10.1097/TA.0b013e3182aa2e66 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AB8YW UT WOS:000332077100056 PM 24553560 ER PT J AU Knudson, MM Evans, TW Fang, R Martin, KD Dorlac, W Gillespie, DL Cherry, KJ Rasmussen, TE AF Knudson, M. Margaret Evans, Thomas W. Fang, Raymond Martin, Kathleen D. Dorlac, Warren Gillespie, David L. Cherry, Kenneth J., Jr. Rasmussen, Todd E. CA Amer Assoc Surg Trauma Soc Vasc Surg Amer Coll Surg Comm Trauma TI A concluding after- action report of the Senior Visiting Surgeon program with the United States Military at Landstuhl Regional Medical Center, Germany SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military-civilian collaboration; Senior Visiting Surgeon program; combat casualty care; research ID COMBAT CASUALTY CARE; CIVILIAN COLLABORATION; TRAUMA SYSTEM; WAR; OPERATIONS; TIMES AB BACKGROUND The Senior Visiting Surgeon (SVS) program at Landstuhl Regional Medical Center (LRMC), Germany, was developed during the wars in Afghanistan and Iraq as a measure to build military-civilian interaction in trauma care and research. The objective of this study was to provide a summary of the program including workload and experiences. An additional objective was to identify factors needed for sustainment of this program during an interwar period. METHODS An electronic, 34-question survey was distributed to 192 surgeons who participated in the SVS program at LRMC, either through the American Association for the Surgery of Trauma or the Society of Vascular Surgery between 2005 and 2012. The survey was composed of multiple-choice and open-ended questions. RESULTS The response rate was 61% (n = 118), with 24% (n = 28) indicating previous military service. These 117 respondents provided 24.5 months of volunteer coverage at LRMC, with 22% (n = 26) performing multiple, 2-week rotations. Visiting surgeons participated in two to five operative cases per week, with the majority of operations related to the management of soft tissue wounds and burns followed by abdominal and vascular procedures, conducted daily multidisciplinary intensive care unit rounds, and collaborated with military surgeons in research projects resulting in 22 publications. More than half (n = 59) of the respondents maintained contact with military colleagues during the 12 months following the rotation. The majority of surveyed surgeons support continuation of the SVS at military facilities in the United States and hosting military surgeons at their civilian trauma center. CONCLUSION This study is the first to quantify the SVS program during the wars in Afghanistan and Iraq. Visiting surgeons provided more than 2 years of combat casualty care during these, the longest wars in US history. Continuation of this program will require expanded military-civilian interaction in trauma care, training, and research during any interwar period. C1 [Knudson, M. Margaret] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Evans, Thomas W.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Fang, Raymond] US Air Force C Stars, Baltimore, MD USA. [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD USA. [Martin, Kathleen D.] Landstuhl Reg Trauma Ctr, Landstuhl, Germany. [Dorlac, Warren] Univ Cincinnati, Cincinnati, OH USA. [Gillespie, David L.] Heart & Vasc Ctr, New Beford, MA USA. Univ Virginia, Charlottesville, VA USA. RP Knudson, MM (reprint author), San Francisco Gen Hosp, Dept Surg, 1001 Potrero Ave, San Francisco, CA 94110 USA. EM pknudson@sfghsurg.ucsf.edu NR 21 TC 5 Z9 5 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2014 VL 76 IS 3 BP 878 EP 883 DI 10.1097/TA.0000000000000159 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AB8YW UT WOS:000332077100061 PM 24553564 ER PT J AU Holcomb, JB Fox, EE Scalea, TM Napolitano, LM Albarado, R Gill, B Dunkin, BJ Kirkpatrick, AW Cotton, BA Inaba, K DuBose, JJ Cohen, AM Azizzadeh, A Brenner, M Cohen, MJ Wade, CE Lumsden, AB Andrassy, R Rhee, PM Bass, BL Mattox, KL Britt, LD Eastman, AB Hoyt, DB Rasmussen, TE AF Holcomb, John B. Fox, Erin E. Scalea, Thomas M. Napolitano, Lena M. Albarado, Rondel Gill, Brijesh Dunkin, Brian J. Kirkpatrick, Andrew W. Cotton, Bryan A. Inaba, Kenji DuBose, Joseph J. Cohen, Alan M. Azizzadeh, Ali Brenner, Megan Cohen, Mitchell J. Wade, Charles E. Lumsden, Alan B. Andrassy, Richard Rhee, Peter M. Bass, Barbara L. Mattox, Kenneth L. Britt, L. D. Eastman, A. Brent Hoyt, David B. Rasmussen, Todd E. CA Catheter-Based Hemorrhage Control TI Current opinion on catheter- based hemorrhage control in trauma patients SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhage control; bleeding; injury; trauma; catheter ID EMERGENCY-DEPARTMENT THORACOTOMY; CRITICALLY-ILL PATIENTS; ENDOVASCULAR BALLOON OCCLUSION; CLINICAL COMPETENCE STATEMENT; INTRAHOSPITAL TRANSPORT; GUIDELINES; AORTA; RESUSCITATION; ANGIOGRAPHY; SURVIVAL C1 [Holcomb, John B.; Fox, Erin E.; Albarado, Rondel; Gill, Brijesh; Cotton, Bryan A.; Wade, Charles E.; Andrassy, Richard] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [DuBose, Joseph J.] Univ Texas Hlth Sci Ctr Houston, Dept Cardiothorac & Vasc Surg, Houston, TX 77030 USA. [Cohen, Alan M.; Azizzadeh, Ali] Univ Texas Hlth Sci Ctr Houston, Dept Radiol, Houston, TX 77030 USA. [Holcomb, John B.; Fox, Erin E.; Cotton, Bryan A.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Sch Med, Ctr Translat Injury Res, Houston, TX 77030 USA. [Mattox, Kenneth L.] Baylor Coll Med, Div Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA. [Rasmussen, Todd E.] US Army Inst Surg Res, Joint Base San Antonio, TX USA. [Scalea, Thomas M.; Brenner, Megan] Univ Maryland, Dept Surg, Div Crit Care, Program Trauma,R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Dunkin, Brian J.; Bass, Barbara L.] Methodist Hosp, Weill Cornell Med Coll, Methodist Hosp Dept Surg, New York, NY USA. [Dunkin, Brian J.] Methodist Hosp, Weill Cornell Med Coll, Methodist Inst Technol Innovat & Educ, New York, NY USA. [Lumsden, Alan B.] Methodist Hosp, Weill Cornell Med Coll, Methodist DeBakey Heart & Vasc Ctr, New York, NY USA. [Inaba, Kenji] Univ So Calif, Div Trauma & Crit Care, Los Angeles, CA USA. [Cohen, Mitchell J.] Univ Calif San Francisco, Sch Med, Dept Surg, Div Gen Surg, San Francisco, CA 94143 USA. [Eastman, A. Brent] Scripps Mem Hosp La Jolla, Scripps Hlth, La Jolla, CA USA. [Napolitano, Lena M.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA. [Rhee, Peter M.] Univ Arizona, Dept Surg, Div Trauma Crit Care & Emergency Surg, Tucson, AZ USA. [Britt, L. D.] Eastern Virginia Med Sch, Dept Surg, Norfolk, VA 23501 USA. [Hoyt, David B.] Amer Coll Surg, Chicago, IL USA. [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB, Canada. [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Crit Care Med, Calgary, AB, Canada. [Kirkpatrick, Andrew W.] Foothills Med Ctr, Reg Trauma Serv, Calgary, AB, Canada. RP Holcomb, JB (reprint author), Univ Texas Hlth Sci Ctr Houston, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. EM john.holcomb@uth.tmc.edu FU Siemens; Brainlab, Inc.; TRUMPF Medical Systems, Inc.; Memorial Hermann Texas Trauma Institute; Methodist Institute for Technology, Innovation, and Education FX This study was funded by an unrestricted educational grant by Siemens; financial support from Brainlab, Inc. and TRUMPF Medical Systems, Inc.; and support from the Memorial Hermann Texas Trauma Institute and the Methodist Institute for Technology, Innovation, and Education. NR 33 TC 14 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2014 VL 76 IS 3 BP 888 EP 893 DI 10.1097/TA.0000000000000133 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AB8YW UT WOS:000332077100064 PM 24553566 ER PT J AU Nilsson, C Godoy-Ramirez, K Hejdeman, B Brave, A Gudmundsdotter, L Hallengard, D Currier, JR Wieczorek, L Hasselrot, K Earl, PL Polonis, VR Marovich, MA Robb, ML Sandstrom, E Wahren, B Biberfeld, G AF Nilsson, Charlotta Godoy-Ramirez, Karina Hejdeman, Bo Brave, Andreas Gudmundsdotter, Lindvi Hallengard, David Currier, Jeffrey R. Wieczorek, Lindsay Hasselrot, Klara Earl, Patricia L. Polonis, Victoria R. Marovich, Mary A. Robb, Merlin L. Sandstrom, Eric Wahren, Britta Biberfeld, Gunnel TI Broad and Potent Cellular and Humoral Immune Responses After a Second Late HIV-Modified Vaccinia Virus Ankara Vaccination in HIV-DNA-Primed and HIV-Modified Vaccinia Virus Ankara-Boosted Swedish Vaccinees SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL; ANTIBODY; CLADE; MVA; IMMUNOGENICITY; INDIVIDUALS; INFECTION; EPITOPES; ENVELOPE AB We have previously shown that an HIV vaccine regimen including three HIV-DNA immunizations and a single HIV-modified vaccinia virus Ankara (MVA) boost was safe and highly immunogenic in Swedish volunteers. A median 38 months after the first HIV-MVA vaccination, 24 volunteers received 10(8) plaque-forming units of HIV-MVA. The vaccine was well tolerated. Two weeks after this HIV-MVA vaccination, 18 (82%) of 22 evaluable vaccinees were interferon (IFN)- enzyme-linked immunospot (ELISpot) reactive: 18 to Gag and 10 (45%) to Env. A median minimal epitope count of 4 to Gag or Env was found in a subset of 10 vaccinees. Intracellular cytokine staining revealed CD4(+) and/or CD8(+) T cell responses in 23 (95%) of 24 vaccinees, 19 to Gag and 19 to Env. The frequency of HIV-specific CD4(+) and CD8(+) T cell responses was equally high (75%). A high proportion of CD4(+) and CD8(+) T cell responses to Gag was polyfunctional with production of three or more cytokines (40% and 60%, respectively). Of the Env-specific CD4(+) T cells 40% were polyfunctional. Strong lymphoproliferative responses to Aldrithiol-2 (AT-2)-treated subtype A, B, C, and A_E virus were demonstrable in 21 (95%) of 22 vaccinees. All vaccinees developed binding antibodies to Env and Gag. Neutralizing antibodies were detected in a peripheral blood mononuclear cell (PBMC)-based assay against subtype B and CRF01_AE viruses. The neutralizing antibody response rates were influenced by the vaccine dose and/or mode of delivery used at the previous HIV-MVA vaccination. Thus, a second late HIV-MVA boost induced strong and broad cellular immune responses and improved antibody responses. The data support further exploration of this vaccine concept. C1 [Nilsson, Charlotta; Godoy-Ramirez, Karina; Brave, Andreas; Gudmundsdotter, Lindvi; Hallengard, David; Earl, Patricia L.; Wahren, Britta; Biberfeld, Gunnel] Swedish Inst Communicable Dis Control, SE-17182 Solna, Sweden. [Nilsson, Charlotta; Brave, Andreas; Gudmundsdotter, Lindvi; Hallengard, David; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden. [Hejdeman, Bo; Sandstrom, Eric] Karolinska Inst, Dept Educ & Clin Res, Sodersjukhuset, Stockholm, Sweden. [Currier, Jeffrey R.; Wieczorek, Lindsay; Polonis, Victoria R.; Marovich, Mary A.; Robb, Merlin L.] Walter Reed Army Inst Res, Dept Retrovirol, Rockville, MD USA. [Hasselrot, Klara] Ctr Mol Med, Infect Dis Unit, Dept Med, Solna, Sweden. [Hasselrot, Klara] Karolinska Univ Hosp, Solna, Sweden. [Earl, Patricia L.] NIAID, NIH, Bethesda, MD 20892 USA. RP Nilsson, C (reprint author), Swedish Inst Communicable Dis Control, Dept Diagnost & Vaccinol, SE-17182 Solna, Sweden. EM charlotta.nilsson@smi.se FU European Union [INCO-DEV A4 ICFP501A4PR03, AVIP 503487]; European Union (Europrise); Swedish International Development Cooperation Agency (Sida) [SWE-2004-120, HIV2004-000809, 2004:813]; Swedish Research Council (Vetenskapsradet) [K2004-16x-07743-19]; Lakare mot AIDS Forskningsfond [04-050301, 01-051101]; Vecura, Karolinska University Hospital; Division of Intramural Research, NIAID, NIH; U.S. Military HIV Research Program; U.S. Military HIV Research Program, WRAIR FX The study was funded by the European Union (INCO-DEV A4 ICFP501A4PR03 to E. S. and AVIP 503487 and Europrise to B. W. and E. S.), the Swedish International Development Cooperation Agency (Sida) (SWE-2004-120 to C.N. and HIV2004-000809 and 2004:813 to G. B.), the Swedish Research Council (Vetenskapsradet, K2004-16x-07743-19 to B. W.), and Lakare mot AIDS Forskningsfond (04-050301 and 01-051101 to E. S.). None of these institutions had any influence on the study or its analysis. Documentation and production of the HIV-DNA vaccines were supported by Vecura, Karolinska University Hospital. Construction of the HIV-1 MVA was supported by the Division of Intramural Research, NIAID, NIH and the U.S. Military HIV Research Program. The production costs were funded by the U.S. Military HIV Research Program, WRAIR. NR 35 TC 7 Z9 8 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAR 1 PY 2014 VL 30 IS 3 BP 299 EP 311 DI 10.1089/aid.2013.0149 PG 13 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AB9FI UT WOS:000332095600018 PM 24090081 ER PT J AU Yeoman, C Yildirim, S Leigh, S Wilson, BA White, B Jasinska, AJ Cramer, JD Turner, T Cerda, G Miller, MEB Gomez, A Carr, M Torralba, M Gillis, M Nelson, KE Stumpf, RM AF Yeoman, Carl Yildirim, Suleyman Leigh, Steven Wilson, Brenda A. White, Bryan Jasinska, Anna J. Cramer, Jennifer Danzy Turner, Trudy Cerda, Gabriella Miller, Margaret E. Berg Gomez, Andres Carr, Monica Torralba, Manolito Gillis, Marcus Nelson, Karen E. Stumpf, Rebecca M. TI The vervet microbiome: determinants of microbial community composition and insights into health and disease SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Meeting Abstract CT 83rd Annual Meeting of the American-Association-of-Physical-Anthropologists CY APR 08-12, 2014 CL Calgary, CANADA SP Amer Assoc Phys Anthropologists C1 [Yeoman, Carl] Montana State Univ, Dept Anim & Range Sci, Bozeman, MT USA. [Yildirim, Suleyman] Walter Reed Army Inst Res, Silver Spring, MD USA. [Leigh, Steven] Univ Colorado, Dept Anthropol, Boulder, CO 80309 USA. [Wilson, Brenda A.] Univ Illinois, Dept Microbiol, Urbana, IL USA. [Wilson, Brenda A.; White, Bryan; Miller, Margaret E. Berg; Gomez, Andres; Stumpf, Rebecca M.] Univ Illinois, Inst Genom Biol, Urbana, IL USA. [Jasinska, Anna J.] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA. [Cramer, Jennifer Danzy] Amer Mil Univ, Dept Sociol Anthropol & Womens Studies, Stanford, CA USA. [Cramer, Jennifer Danzy] Amer Publ Univ, Charlestown, MA USA. [Turner, Trudy] Univ Wisconsin Milwaukee, Dept Anthropol, Milwaukee, WI USA. [Cerda, Gabriella; Carr, Monica; Stumpf, Rebecca M.] Univ Illinois, Dept Anthropol, Urbana, IL USA. [Torralba, Manolito; Gillis, Marcus; Nelson, Karen E.] J Craig Venter Inst, Santa Barbara, CA USA. NR 0 TC 0 Z9 0 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-9483 EI 1096-8644 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD MAR PY 2014 VL 153 SU 58 SI SI BP 279 EP 279 PG 1 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA AA6RH UT WOS:000331225100956 ER PT J AU Magulick, JP Frei, CR Ali, SK Mortensen, EM Pugh, MJ Oramasionwu, CU Daniels, KR Mansi, IA AF Magulick, John P. Frei, Christopher R. Ali, Sayed K. Mortensen, Eric M. Pugh, Mary Jo Oramasionwu, Christine U. Daniels, Kelly R. Mansi, Ishak A. TI The Effect of Statin Therapy on the Incidence of Infections: A Retrospective Cohort Analysis SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Fungal; Influenza; Infection; Statin ID COMMUNITY-ACQUIRED PNEUMONIA; COA REDUCTASE INHIBITORS; POPULATION-BASED COHORT; NITRIC-OXIDE; ENDOTHELIAL-CELLS; UNITED-STATES; MORTALITY; OUTCOMES; RISK; SEPSIS AB Background: Statins have been postulated to prevent infection through immunomodulatory effects. Objectives: To compare the incidence of infections in statin users to that in nonusers within the same health care system. Methods: This was a retrospective cohort study of patients enrolled as Tricare Prime or Plus in the San Antonio military multimarket. Statin users were patients who received a statin for at least 3 months between October 1, 2004 and September 30, 2005. Nonusers were patients who did not receive a statin within the study period (October 1, 2003-September 30, 2009). Inpatient and outpatient International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes were used to determine the incidence of infections during the follow-up period (October 1, 2005-September 30, 2009) via multivariable regression analysis and time to infection via Cox regression analysis. Results: Of 45,247 patients who met the study criteria, 12,981 (29%) were statin users and 32,266 were nonusers. After adjustments for age, gender, Charlson Comorbidity Score, tobacco use, alcohol abuse/dependence, health care utilization and use of specific medication classes, statin use was associated with an increased incidence of common infections (odds ratio [OR]: 1.13; 95% confidence interval [CI]: 1.06-1.19) but not influenza or fungal infections (OR: 1.06, 95% CI: 0.80-1.39; OR: 0.97; 95% CI: 0.91-1.04, respectively). Time-to-first infection was similar in statin users and nonusers in all infection categories examined. Conclusions: Statin use was associated with an increased incidence of common infections but not influenza or fungal infections. This study does not support a protective role of statins in infection prevention; however, the influence of potential confounders cannot be excluded. C1 [Magulick, John P.; Ali, Sayed K.] San Antonio Mil Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. [Frei, Christopher R.; Daniels, Kelly R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. [Frei, Christopher R.; Daniels, Kelly R.] Univ Texas Hlth Sci Ctr San Antonio, Pharmacotherapy Educ & Res Ctr, Sch Med, San Antonio, TX 78229 USA. [Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, VA North Texas Hlth Care Syst, Dallas, TX 75390 USA. [Pugh, Mary Jo] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Pugh, Mary Jo] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Oramasionwu, Christine U.] Univ N Carolina, UNC Eshelman Sch Pharm, Div Pharmaceut Outcomes & Policy, Chapel Hill, NC USA. [Mansi, Ishak A.] Brooke Army Med Ctr, San Antonio, TX USA. [Mansi, Ishak A.] Uniformed Serv Univ Hlth Sci, San Antonio, TX USA. [Mansi, Ishak A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mansi, IA (reprint author), San Antonio Mil Med Ctr, Internal Med Serv, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil OI Mortensen, Eric/0000-0002-3880-5563 FU U.S. National Institutes of Health (NIH) [RR025766]; AstraZeneca; Bristol Myers Squibb; Elan; Forest; Ortho-McNeil Janssen; Pfizer; VA Health Services Research and Development Service [DHI 09-237] FX C.R. Frei was supported by the U.S. National Institutes of Health (NIH) in the form of an NIH/KL2 career development award (RR025766) during the conduct of this study. C. R. Frei has received research grants and/or served as a scientific consultant/advisor for AstraZeneca, Bristol Myers Squibb, Elan, Forest, Ortho-McNeil Janssen and Pfizer. M.J.P. recieved support from VA Health Services Research and Development Service DHI 09-237. The remaining authors have no financial or other conflicts of interest to disclose. NR 64 TC 5 Z9 5 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 EI 1538-2990 J9 AM J MED SCI JI Am. J. Med. Sci. PD MAR PY 2014 VL 347 IS 3 BP 211 EP 216 DI 10.1097/MAJ.0b013e31828318e2 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AC0YF UT WOS:000332220700009 PM 23426088 ER PT J AU Ruhl, DS Cable, BB Rieth, KKS AF Ruhl, Douglas S. Cable, Benjamin B. Rieth, Katherine K. S. TI Emergent Treatment of Button Batteries in the Esophagus: Evolution of Management and Need for Close Second-Look Esophagoscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 10-11, 2013 CL Orlando, FL SP Amer Broncho Esophagol Assoc DE button battery; esophageal injury; esophagoscopy ID CAUSTIC INGESTION; CHILDREN; PROTOCOL; BURN; DOGS AB Objectives: The evolving epidemiology of pediatric button battery ingestion is alarming. Currently, assessment of the degree of damage relies heavily on the initial esophagoscopy in a manner similar to the management of caustic ingestion. We have noted that use of this classic approach may delay the return to normal oral intake. Using several cases treated at our institution, we illustrate the value of "close second-look esophagoscopy" (CSLE) in expediting a return to normal oral intake after button battery ingestion. Methods: We present a retrospective case series. Results: Five patients (I I to 18 months of age) with button batteries trapped in the cervical esophagus were recently managed at our institution. The batteries were lodged in the esophagus for durations ranging from 6 hours to 4 months. Three cases of initial grade III circumferential necrotic injury were downgraded to grade IIa after a CSLE performed 2 to 4 days after removal, and their management was appropriately changed. Conclusions: The injury and healing of cases of button batteries in the proximal esophagus appear to be variable; caustic injury, electrical mucosal damage, and direct pressure are thought to be several contributory factors. Performing a CSLE within 2 to 4 days after battery removal may provide more useful prognostic information. In certain cases, downgrading of the injury may facilitate an earlier return to an oral diet, use of fewer diagnostic tests, and a shorter hospital stay. The utility and timing of imaging, management of diet and medications, and acceptable follow-up plans are discussed within the context of guiding future research. C1 [Ruhl, Douglas S.; Cable, Benjamin B.; Rieth, Katherine K. S.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM douglas.s.ruhl.mil@mail.mil OI Ruhl, Douglas/0000-0002-7411-2385 NR 18 TC 2 Z9 2 U1 0 U2 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 206 EP 213 DI 10.1177/0003489414522969 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700007 PM 24633947 ER PT J AU Thompson, MG Black, CC Pavlicek, RL Honnold, CL Wise, MC Alamneh, YA Moon, JK Kessler, JL Si, YZ Williams, R Yildirim, S Kirkup, BC Green, RK Hall, ER Palys, TJ Zurawski, DV AF Thompson, Mitchell G. Black, Chad C. Pavlicek, Rebecca L. Honnold, Cary L. Wise, Matthew C. Alamneh, Yonas A. Moon, Jay K. Kessler, Jennifer L. Si, Yuanzheng Williams, Robert Yildirim, Suleyman Kirkup, Benjamin C., Jr. Green, Romanza K. Hall, Eric R. Palys, Thomas J. Zurawski, Daniel V. TI Validation of a Novel Murine Wound Model of Acinetobacter baumannii Infection SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID EPITHELIAL-CELLS; PROTEIN PLAYS; MICE; PNEUMONIA; EFFICACY; BIOFILMS; RIFAMPIN; SEPSIS; TRAUMA; OSTEOMYELITIS AB Patients recovering from traumatic injuries or surgery often require weeks to months of hospitalization, increasing the risk for wound and surgical site infections caused by ESKAPE pathogens, which include A. baumannii (the ESKAPE pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). As new therapies are being developed to counter A. baumannii infections, animal models are also needed to evaluate potential treatments. Here, we present an excisional, murine wound model in which a diminutive inoculum of a clinically relevant, multidrug-resistant A. baumannii isolate can proliferate, form biofilms, and be effectively treated with antibiotics. The model requires a temporary, cyclophosphamide-induced neutropenia to establish an infection that can persist. A 6-mm-diameter, full-thickness wound was created in the skin overlying the thoracic spine, and after the wound bed was inoculated, it was covered with a dressing for 7 days. Uninoculated control wounds healed within 13 days, whereas infected, placebo-treated wounds remained unclosed beyond 21 days. Treated and untreated wounds were assessed with multiple quantitative and qualitative techniques that included gross pathology, weight loss and recovery, wound closure, bacterial burden, 16S rRNA community profiling, histopathology, peptide nucleic acid-fluorescence in situ hybridization, and scanning electron microscopy assessment of biofilms. The range of differences that we are able to identify with these measures in antibiotic-versus placebo-treated animals provides a clear window within which novel antimicrobial therapies can be assessed. The model can be used to evaluate antimicrobials for their ability to reduce specific pathogen loads in wounded tissues and clear biofilms. Ultimately, the mouse model approach allows for highly powered studies and serves as an initial multifaceted in vivo assessment prior to testing in larger animals. C1 [Thompson, Mitchell G.; Black, Chad C.; Alamneh, Yonas A.; Moon, Jay K.; Kessler, Jennifer L.; Si, Yuanzheng; Yildirim, Suleyman; Kirkup, Benjamin C., Jr.; Green, Romanza K.; Palys, Thomas J.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Honnold, Cary L.; Wise, Matthew C.] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. [Pavlicek, Rebecca L.; Hall, Eric R.] Naval Med Res Ctr, Dept Wound Infect, Silver Spring, MD USA. [Williams, Robert] Naval Med Res Ctr, Dept Pathol, Silver Spring, MD USA. [Kirkup, Benjamin C., Jr.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Infect Dis, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. EM daniel.v.zurawski.ctr@mail.mil RI Kirkup, Benjamin/C-3610-2009; OI Kirkup, Benjamin/0000-0002-8722-6218; Zurawski, Daniel/0000-0002-7920-5601 FU Military Infectious Diseases Research Program (MIDRP); Defense Medical Research and Development Program (DMRDP) FX The research presented here was supported and funded via multiple grants from the Military Infectious Diseases Research Program (MIDRP) and the Defense Medical Research and Development Program (DMRDP). NR 48 TC 17 Z9 17 U1 2 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2014 VL 58 IS 3 BP 1332 EP 1342 DI 10.1128/AAC.01944-13 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AC0HJ UT WOS:000332175100009 PM 24342634 ER PT J AU Farrell, ME Holthoff, EL Pellegrino, PM AF Farrell, Mikella E. Holthoff, Ellen L. Pellegrino, Paul M. TI Surface-Enhanced Raman Scattering Detection of Ammonium Nitrate Samples Fabricated Using Drop-on-Demand Inkjet Technology SO APPLIED SPECTROSCOPY LA English DT Article DE Ammonium nitrate; Surface enhanced Raman scattering; SERS; Energetic; Hazard; Klarite ID MOLECULARLY IMPRINTED POLYMERS; POLYMORPHIC PHASE-TRANSITION; SILVER ELECTRODE; EXPLOSIVES PARTICLES; MASS-SPECTROMETRY; TRACE EXPLOSIVES; SINGLE-MOLECULE; UREA NITRATE; IV-III; SPECTROSCOPY AB The United States Army and the first responder community are increasingly focusing efforts on energetic materials detection and identification. Main hazards encountered in theater include home-made explosives and improvised explosive devices, in part fabricated from simple components like ammonium nitrate (AN). In order to accurately detect and identify these unknowns (energetic or benign), fielded detection systems must be accurately trained using well-understood universal testing substrates. These training substrates must contain target species at known concentrations and recognized polymorphic phases. Ammonium nitrate is an explosive precursor material that demonstrates several different polymorphic phases dependent upon how the material is deposited onto testing substrates. In this paper, known concentrations of AN were uniformly deposited onto commercially available surface-enhanced Raman scattering (SERS) substrates using a drop-on-demand inkjet printing system. The phase changes observed after the deposition of AN under several solvent conditions are investigated. Characteristics of the collected SERS spectra of AN are discussed, and it is demonstrated that an understanding of the exact nature of the AN samples deposited will result in an increased ability to accurately and reliably "train" hazard detection systems. C1 [Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Lab, RDRL SEE E, Adelphi, MD 20783 USA. RP Farrell, ME (reprint author), US Army Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mikella.e.farrell.civ@mail.mil NR 82 TC 8 Z9 8 U1 3 U2 68 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD MAR PY 2014 VL 68 IS 3 BP 287 EP 296 DI 10.1366/13-07035 PG 10 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA AB9UP UT WOS:000332141500004 PM 24666945 ER PT J AU Kautt, WH AF Kautt, W. H. TI The Black and Tans: British Police and Auxiliaries in the Irish War of Independence, 1920-1921 SO BRITAIN AND THE WORLD LA English DT Book Review C1 [Kautt, W. H.] US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. RP Kautt, WH (reprint author), US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU EDINBURGH UNIV PRESS PI EDINBURGH PA 22 GEORGE SQUARE, EDINBURGH EH8 9LF, MIDLOTHIAN, SCOTLAND SN 2043-8567 EI 2043-8575 J9 BRIT WORLD JI Br. World PD MAR PY 2014 VL 7 IS 1 BP 133 EP 136 DI 10.3366/brw.2014.0128 PG 4 WC History SC History GA AB6CW UT WOS:000331876200012 ER PT J AU Jelinek, B Eshraghi, M Felicelli, S Peters, JF AF Jelinek, Bohurnir Eshraghi, Mohsen Felicelli, Sergio Peters, John F. TI Large-scale parallel lattice Boltzmann-cellular automaton model of two-dimensional dendritic growth SO COMPUTER PHYSICS COMMUNICATIONS LA English DT Article DE Solidification; Dendrite growth; Lattice Boltzmann; Cellular automaton; Parallel computing ID PHASE-FIELD; SOLIDIFICATION; SIMULATION; PERFORMANCE; EQUATION AB An extremely scalable lattice Boltzmann (LB)-cellular automaton (CA) model for simulations of two-dimensional (2D) dendritic solidification under forced convection is presented. The model incorporates effects of phase change, solute diffusion, melt convection, and heat transport. The LB model represents the diffusion, convection, and heat transfer phenomena. The dendrite growth is driven by a difference between actual and equilibrium liquid composition at the solid-liquid interface. The CA technique is deployed to track the new interface cells. The computer program was parallelized using the Message Passing Interface (MPI) technique. Parallel scaling of the algorithm was studied and major scalability bottlenecks were identified. Efficiency loss attributable to the high memory bandwidth requirement of the algorithm was observed when using multiple cores per processor. Parallel writing of the output variables of interest was implemented in the binary Hierarchical Data Format 5 (HDF5) to improve the output performance, and to simplify visualization. Calculations were carried out in single precision arithmetic without significant loss in accuracy, resulting in 50% reduction of memory and computational time requirements. The presented solidification model shows a very good scalability up to centimeter size domains, including more than ten million of dendrites. Program summary Program title: 2Ddend Catalogue identifier: AEQZ_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEQZ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, UK Licensing provisions: Standard CPC license, http://cpc.cs.qub.ac.uk/licenceilicence.html No. of lines in distributed program, including test data, etc.: 29,767 No. of bytes in distributed program, including test data, etc.: 3131,367 Distribution format: tar.gz Programming language: Fortran 90. Computer: Linux PC and clusters. Operating system: Linux. Has the code been vectorized or parallelized?: Yes. Program is parallelized using MPI. Number of processors used: 1-50,000 RAM: Memory requirements depend on the grid size Classification: 6.5, 7.7. External routines: MPI (http://www.mcs.anl.gov/research/projects/mpia HDF5 (http://www.hdfgroup.org/HDF5/) Nature of problem: Dendritic growth in undercooled Al-3 wt% Cu alloy melt under forced convection. Solution method: The lattice Boltzmann model solves the diffusion, convection, and heat transfer phenomena. The cellular automaton technique is deployed to track the solid/liquid interface. Restrictions: Heat transfer is calculated uncoupled from the fluid flow. Thermal diffusivity is constant. Unusual features: Novel technique, utilizing periodic duplication of a pre-grown "incubation" domain, is applied for the scaleup test. Running time: Running time varies from minutes to days depending on the domain size and number of computational cores. (C) 2013 Elsevier B.V. All rights reserved. C1 [Jelinek, Bohurnir; Eshraghi, Mohsen; Felicelli, Sergio] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Eshraghi, Mohsen; Felicelli, Sergio] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Peters, John F.] US Army ERDC, Vicksburg, MS 39180 USA. RP Felicelli, S (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. EM felicelli@me.msstate.edu FU US Army Corps of Engineers [W912HZ-09-C-0024]; National Science Foundation [CBET-0931801]; NSF XSEDE allocations [TG-ECS120004, TG-ECS120006] FX This work was funded by the US Army Corps of Engineers through contract number W912HZ-09-C-0024 and by the National Science Foundation under Grant No. CBET-0931801. Computational resources at the MSU HPC2 center (Talon) and XSEDE (Kraken at NICS, Gordon at SDSC, Lonestar at TACC) were used. Computational packages HPCTooLKIT [25], PERFEXPERT [28], and CRAY PAT [29] were used to assess the code performance and scalability bottlenecks. Images were made using OpenDX with the DXHF5 module [30] and Paraview tool http://www.paraview.org/. This study was performed with the XSEDE extended collaborative support guide of Reuben Budiardja at NICS. An excellent guide and consultation on HPCTooLKIT was provided by John MellorCrummey, Department of Computer Science, Rice University. The authors also acknowledge the Texas Advanced Computing Center (TACC) at the University of Texas at Austin for providing HPC resources, training, and consultation (James Brown, Ashay Rane) that have contributed to the research results reported within this paper. URL: http://www.tacc.utexas.edu; Access to the Kraken supercomputer was provided through NSF XSEDE allocations TG-ECS120004 and TG-ECS120006. NR 30 TC 10 Z9 13 U1 3 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-4655 EI 1879-2944 J9 COMPUT PHYS COMMUN JI Comput. Phys. Commun. PD MAR PY 2014 VL 185 IS 3 BP 939 EP 947 DI 10.1016/j.cpc.2013.09.013 PG 9 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA AB6SF UT WOS:000331919100027 ER PT J AU Smith, J Cusatis, G Pelessone, D Landis, E O'Daniel, J Baylot, J AF Smith, Jovanca Cusatis, Gianluca Pelessone, Daniele Landis, Eric O'Daniel, James Baylot, James TI Discrete modeling of ultra-high-performance concrete with application to projectile penetration SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ultra-high-performance concrete; Lattice Discrete Particle Model; Fracture; Fragmentation; Penetration ID HIGH-STRENGTH CONCRETE; ARBITRARY EVOLVING CRACKS; FIBER-REINFORCED CONCRETE; REACTIVE POWDER CONCRETE; SHEAR LATTICE MODEL; CEMENT-SLAG MORTARS; HIGH-STRAIN RATES; COMPRESSIVE STRENGTH; DYNAMIC FRACTURE; MICROPLANE MODEL AB In this paper, the Lattice Discrete Particle Model for fiber reinforced concrete (LDPM-F) is calibrated and validated with reference to a new high-strength, ultra-high-performance concrete (UHPC) named CORTUF and applied to the simulation of projectile penetration. LDPM-F is a three-dimensional model that simulates concrete at the length scale of coarse aggregate pieces (meso-scale) through the adoption of a discrete modeling framework for both fiber reinforcement and embedding matrix heterogeneity. In this study, CORTUF parameter identification is performed using basic laboratory fiber pull-out experiments and experiments relevant to a CORTUF mix without fiber reinforcement. Extensive comparisons of the numerical predictions against experimental data that were not used during the calibration phase (relevant to both plain CORTUF and CORTUF with fiber reinforcement) are used to validate the calibrated model and to provide solid evidence of its predictive capabilities. Simulations are then carried out to investigate the behavior of protective CORTUF panels subjected to projectile penetration, and the numerical results are discussed with reference to available experimental data obtained at the Engineering Research and Development Center (ERDC). (C) 2013 Elsevier Ltd. All rights reserved. C1 [Smith, Jovanca; Cusatis, Gianluca] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA. [Pelessone, Daniele] ES3, San Diego, CA 92101 USA. [Landis, Eric] Univ Maine, Dept Civil & Environm Engn, Orono, ME 04469 USA. [O'Daniel, James; Baylot, James] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Cusatis, G (reprint author), Northwestern Univ, Robert R McCormick Sch Engn & Appl Sci, Tech Bldg Room A125,2145 N Sheridan Rd, Evanston, IL 60208 USA. EM jsmith2014@u.northwestern.edu; g-cusatis@northwestern.edu; peless@es3inc.com; landis@maine.edu; James.L.O'Daniel@usace.army.mil; James.T.Baylot@usace.army.mil RI Cusatis, Gianluca/G-2539-2011; OI Cusatis, Gianluca/0000-0001-7436-3910 FU U.S. Army Engineer Research and Development Center; DTRA [HDTRA1-09-1-0029]; Northwestern University and Sandia National Labs FX This effort was sponsored by the U.S. Army Engineer Research and Development Center. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory. The work of the first and second authors was also supported under DTRA grant No. HDTRA1-09-1-0029 to Rensselaer Polytechnic Institute (with subcontracts to Northwestern University and Sandia National Labs). NR 114 TC 22 Z9 22 U1 6 U2 43 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAR PY 2014 VL 65 BP 13 EP 32 DI 10.1016/j.ijimpeng.2013.10.008 PG 20 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AB6SQ UT WOS:000331920200002 ER PT J AU de Bejar, LA AF de Bejar, Luis A. TI Simulation of standoff vertical-mortar fragment impact momentum on round targets SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Fragment impact momentum; Mortar fragmentation; Mortar fragment simulation; Target vulnerability under mortars; Vertical arena test AB The probability distribution of the fragment strike location on round targets within the scope of the expanding cylindrical metal case of a mortar at the center of a vertical arena test is formulated. Recognizing the axi-symmetric configuration, the description of the strike location in Cartesian coordinates is transformed into local polar coordinates. The theoretical distribution is experimentally verified approximately and the intervening parameters are identified. The number of fragments ejected upon case disintegration is estimated using the well-known Mott's model. The distribution of the fragment weight was identified in a previous investigation as Weibull with specific parameters according to the fragment category: either finger or chunk. The impact momentum for the fragment rain upon striking the target is then simulated. An example of application illustrates the practical formulation of probabilistic statements concerning the vulnerability assessment of a set of round targets surrounding a central cylindrical mortar in a vertical arena test arrangement. Published by Elsevier Ltd. C1 US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), US Army Engn Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Luis.A.DeBejar@erdc.usace.army.mil FU U.S. Department of the Army; Army Military Engineering Basic Research Program FX This investigation was sponsored by the U.S. Department of the Army under the joint support of the Army Technology Objective entitled Protection against Terrorist and Conventional Attacks in Contingency Environments and the Army Military Engineering Basic Research Program. The author gratefully acknowledges this support. Permission to publish was granted by the Director of the Geotechnical and Structures Laboratory of the U.S. Army Engineer Research and Development Center. NR 17 TC 0 Z9 0 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAR PY 2014 VL 65 BP 102 EP 109 DI 10.1016/j.ijimpeng.2013.11.006 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AB6SQ UT WOS:000331920200009 ER PT J AU Fox, DM Lee, JS AF Fox, D. M. Lee, J. S. TI The influence of water, dry sand, and unsaturated sand constitutive behavior on the blast response of a rigid target SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Soil; Blast; Small-scale; ALE; Computation ID DETONATIONS AB A combination of soil characterizations, computations and small-scale experiments were performed in order to better understand the behavior of shallow-buried explosives. The constitutive behavior of the soil was determined using a combination of high pressure quasi-static tests and effective stress theory; the motion of rigid objects impacted by the material flow resulting from blast experiments was measured by use of high-speed digital video photography. Computations that simulated the blast experiments were performed by use of an arbitrary Lagrangian Eulerian (ALE) treatment in a nonlinear finite element code. We used a factorial design approach to deduce the underlying mechanics of such systems. Using this approach, we found that, for water and for dry and partially saturated granular materials lower deviatoric yield strength was a key factor which caused sand or water to flow more readily thereby producing higher levels of momentum loading to bodies in close proximity to the buried explosive. We found that higher bulk stiffness and mass density were moderately important factors although they were less significant than was the shear strength of the medium containing the explosive. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Fox, D. M.] Army Res Lab, Blast Protect Branch, Aberdeen Proving Ground, MD 21005 USA. [Fox, D. M.] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA. [Lee, J. S.] Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea. RP Lee, JS (reprint author), Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea. EM joonlee@yonsei.ac.kr FU Army Research Laboratory FX We are very grateful to Jon Windham, Jay Ehrgott, and Steve Akers from the US Army Engineer Research and Development Center for their willingness to share their deep and thorough understanding of soil behavior. We are also grateful to Bill Fourney, Uli Leiste, and Les Taylor for sharing so much of the fruit of their experience with the phenomenology of shallow buried explosives. We are grateful to Neil Gniazdowski and Ed Fioravante of the Army Research Laboratory for supporting this work. NR 32 TC 0 Z9 0 U1 1 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAR PY 2014 VL 65 BP 163 EP 173 DI 10.1016/j.ijimpeng.2013.10.005 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AB6SQ UT WOS:000331920200014 ER PT J AU Rickards, CA Vyas, N Ryan, KL Ward, KR Andre, D Hurst, GM Barrera, CR Convertino, VA AF Rickards, Caroline A. Vyas, Nisarg Ryan, Kathy L. Ward, Kevin R. Andre, David Hurst, Gennifer M. Barrera, Chelsea R. Convertino, Victor A. TI Are you bleeding? Validation of a machine-learning algorithm for determination of blood volume status: application to remote triage SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE triage algorithm; lower body negative pressure; exercise; central hypovolemia ID HEART-RATE-VARIABILITY; COMBAT CASUALTY CARE; TRAUMA PATIENTS; CENTRAL HYPOVOLEMIA; STROKE VOLUME; HEMORRHAGE; MORTALITY; PRESSURE; DEATH; HEMODYNAMICS AB Due to limited remote triage monitoring capabilities, combat medics cannot currently distinguish bleeding soldiers from those engaged in combat unless they have physical access to them. The purpose of this study was to test the hypothesis that low-level physiological signals can be used to develop a machine-learning algorithm for tracking changes in central blood volume that will subsequently distinguish central hypovolemia from physical activity. Twenty-four subjects underwent central hypovolemia via lower body negative pressure (LBNP), and a supine-cycle exercise protocol. Exercise workloads were determined by matching heart rate responses from each LBNP level. Heart rate and stroke volume (SV) were measured via Finometer. ECG, heat flux, skin temperature, galvanic skin response, and two-axis acceleration were obtained from an armband (SenseWear Pro2) and used to develop a machine-learning algorithm to predict changes in SV as an index of central blood volume under both conditions. The algorithm SV was retrospectively compared against Finometer SV. A model was developed to determine whether unknown data points could be correctly classified into these two conditions using leave-one-out cross-validation. Algorithm vs. Finometer SV values were strongly correlated for LBNP in individual subjects (mean r = 0.92; range 0.75-0.98), but only moderately correlated for exercise (mean r = 0.50; range -0.23-0.87). From the first level of LBNP/exercise, the machine-learning algorithm was able to distinguish between LBNP and exercise with high accuracy, sensitivity, and specificity (all >= 90%). In conclusion, a machine-learning algorithm developed from low-level physiological signals could reliably distinguish central hypovolemia from exercise, indicating that this device could provide battlefield remote triage capabilities. C1 [Rickards, Caroline A.] Univ North Texas Hlth Sci Ctr, Dept Integrat Physiol, Ft Worth, TX 76107 USA. [Rickards, Caroline A.; Barrera, Chelsea R.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Vyas, Nisarg; Andre, David] BodyMedia Adv Dev Inc, Pittsburgh, PA USA. [Ryan, Kathy L.; Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Ward, Kevin R.] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA. [Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. [Hurst, Gennifer M.] Pittsburgh Tissue Engn Initiat, Pittsburgh, PA USA. RP Rickards, CA (reprint author), Univ North Texas Hlth Sci Ctr, Dept Integrat Physiol, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA. EM caroline.rickards@unthsc.edu FU US Army Combat Casualty Care Program FX This research was supported by funding from the US Army Combat Casualty Care Program. NR 27 TC 3 Z9 3 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR PY 2014 VL 116 IS 5 BP 486 EP 494 DI 10.1152/japplphysiol.00012.2013 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AC3JR UT WOS:000332414300003 PM 24408992 ER PT J AU Lester, ME Sharp, MA Werling, WC Walker, LA Cohen, BS Ruediger, TM AF Lester, Mark E. Sharp, Marilyn A. Werling, William C. Walker, Leila A. Cohen, Bruce S. Ruediger, Thomas M. TI Effect of Specific Short-Term Physical Training on Fitness Measures in Conditioned Men SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE test-retest reliability; normative values; agility; strength ID RISK-FACTORS; MUSCLE MASS; PERFORMANCE-CHARACTERISTICS; FOOTBALL PLAYERS; BODY-COMPOSITION; ELDERLY-PEOPLE; STRENGTH; ARMY; INJURIES; WOMEN AB Lester, ME, Sharp, MA, Werling, WC, Walker, LA, Cohen, BS, and Ruediger, TM. Effect of specific short-term physical training on fitness measures in conditioned men. J Strength Cond Res 28(3): 679-688, 2014-Physical training programs that enhance battlefield-related fitness needs have been increasingly advocated as operational demands on the US military have increased, but few studies have evaluated program effectiveness. The purpose of this study was to compare a novel 7-week physical training program with traditional army physical fitness training in improving the selected measures of physical fitness and military task performance. One hundred and eighty subjects performed a 30-m rush wearing a fighting load, a simulated casualty recovery wearing a fighting load, a 1-repetition maximum bench press, a maximum repetition pull-up test, a medicine ball put, a vertical jump, and a T-test agility drill to establish test-retest reliability and normative reference values. One hundred thirty-three subjects were assigned by block randomization to either traditional Army physical training (TT) of calisthenics and running or a novel program (NT) of calisthenics, resistance, aerobic, speed, power, and agility training. The results indicated that between-day reliability was high (intraclass correlation coefficients [ICCs] 3,1; 0.87-0.98) for all measures except for the casualty recovery (ICC 3,1; 0.67). Reliability improved for all the measures that were averaged over 3 trials (ICC 3,3; 0.93-0.95). The NT was superior to TT in improving bench press (8 vs. 3%; p < 0.01), medicine ball put (7 vs. 1%; p < 0.01), 30-m rush times (5 vs. 1%; p < 0.01), and casualty recovery times (17 vs. -15%; p < 0.01). These findings suggest that a short-term physical training program is effective in improving strength, power, and speed among previously conditioned men. Future studies should determine if similar training programs mitigate the injury risk in this population. C1 [Lester, Mark E.] Univ Utah, Phys Therapy Dept, Salt Lake City, UT 84112 USA. [Sharp, Marilyn A.; Walker, Leila A.; Cohen, Bruce S.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Werling, William C.] Evans Army Community Hosp, Ft Carson, CA USA. [Ruediger, Thomas M.] Univ Michigan, Phys Therapy Dept, Flint, MI 48503 USA. RP Lester, ME (reprint author), Univ Utah, Phys Therapy Dept, Salt Lake City, UT 84112 USA. EM mark.e.lester5@gmail.com FU Health Promotion and Prevention Initiatives Program FX The authors would like to thank the Ft. Drum Physical therapy Department for their help in administering the training programs and assisting in test administration in this study. They would also like to thank Ms. Amanda Centi, and SSG Darnell Dobbins for their assistance in administering fitness tests. All the potential volunteers were briefed on the objectives of the study and read and signed an informed consent document approved by the institutional review boards at Walter Reed Army Medical Center and the US Army Research Institute of Environmental Medicine. This project was supported in part with funding from the Health Promotion and Prevention Initiatives Program, which is managed through the US Army Center for Health Promotion and Preventive Medicine. There are no conflicts of interest to report. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. The results of this study do not constitute an endorsement by the National Strength and Conditioning Association. NR 31 TC 4 Z9 4 U1 0 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAR PY 2014 VL 28 IS 3 BP 679 EP 688 DI 10.1519/JSC.0b013e318299912b PG 10 WC Sport Sciences SC Sport Sciences GA AB9ZA UT WOS:000332153100013 PM 23660572 ER PT J AU Sweeney, LM Sommerville, DR Channel, SR AF Sweeney, Lisa M. Sommerville, Douglas R. Channel, Stephen R. TI Impact of Non-constant Concentration Exposure on Lethality of Inhaled Hydrogen Cyanide SO TOXICOLOGICAL SCIENCES LA English DT Article DE hydrogen cyanide; nose-only inhalation; acute lethality; non-constant concentrations; pulsed exposures; toxic load model; ten Berge model ID TOXICITY; RATS; RISK AB The ten Berge model, also known as the toxic load model, is an empirical approach in hazard assessment modeling for estimating the relationship between the inhalation toxicity of a chemical and the exposure duration. The toxic load (TL) is normally expressed as a function of vapor concentration (C) and duration (t), with TL equaling C-n t being a typical form. Hypothetically, any combination of concentration and time that yields the same toxic load will give a constant biological response. These formulas have been developed and tested using controlled, constant concentration animal studies, but the validity of applying these assumptions to time-varying concentration profiles has not been tested. Experiments were designed to test the validity of the model under conditions of non-constant acute exposure. Male Sprague-Dawley rats inhaled constant or pulsed concentrations of hydrogen cyanide (HCN) generated in a nose-only exposure system for 5, 15, or 30min. The observed lethality of HCN for the 11 different C versus t profiles was used to evaluate the ability of the model to adequately describe the lethality of HCN under the conditions of non-constant inhalation exposure. The model was found to be applicable under the tested conditions, with the exception of the median lethality of very brief, high concentration, discontinuous exposures. C1 [Sweeney, Lisa M.] Naval Med Res Unit Dayton, Henry M Jackson Fdn Adv Mil Med, Wright Patterson AFB, OH 45433 USA. [Sommerville, Douglas R.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Channel, Stephen R.] Leidos, Linton, IN 47441 USA. RP Sweeney, LM (reprint author), Naval Med Res Unit Dayton, Henry M Jackson Fdn Adv Mil Med, Wright Patterson AFB, OH 45433 USA. EM LMS29@cwru.edu RI Sweeney, Lisa/K-5114-2012 OI Sweeney, Lisa/0000-0002-4672-7358 FU Defense Threat Reduction Agency FX This work was supported by the Defense Threat Reduction Agency. Dr Sweeney's efforts were conducted under Work Unit Number H1107. NR 32 TC 6 Z9 6 U1 2 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD MAR PY 2014 VL 138 IS 1 BP 205 EP 216 DI 10.1093/toxsci/kft277 PG 12 WC Toxicology SC Toxicology GA AB8MW UT WOS:000332045500018 PM 24336460 ER PT J AU Cheng, XG Tsao, C Sylvia, VL Cornet, D Nicolella, DP Bredbenner, TL Christy, RJ AF Cheng, XingGuo Tsao, Christopher Sylvia, Victor L. Cornet, Douglas Nicolella, Daniel P. Bredbenner, Todd L. Christy, Robert J. TI Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells SO ACTA BIOMATERIALIA LA English DT Article DE Collagen; Nanoparticle; Growth Factors; Stem cell; Tendon ID KNITTED SILK SCAFFOLD; TENDON REPAIR; PDGF-BB; IN-VIVO; CONTROLLED DELIVERY; LIGAMENT; BIOSCAFFOLDS; BIOMECHANICS; CONSTRUCTS; HISTOLOGY AB In order to enhance the healing potential of an injured tendon, we have prepared a novel biomimetic aligned collagen-nanoparticle (NP) composite fiber using an electrochemical process. The aligned collagen-NP composite fiber is designed to affect the cellular activity of adipose-derived stem cells (ADSCs) through two different ways: (i) topographic cues from the alignment of collagen fibril and (ii) controlled release of platelet-derived growth factors (PDGFs) from the NPs. PDGF released from collagen-NP fibers significantly enhanced the proliferation of ADSCs when tested for up to 7 days. Moreover, compared to random collagen fibers with PDGFs, aligned collagen-NP fibers significantly promoted the desirable tenogenic differentiation of ADSCs, as evidenced by an increased level of tendon markers such as tenomodulin and scleraxis. On the other hand, no undesirable osteogenic differentiation, as measured by the unchanged level of alkaline phosphatase and osteocalcin, was observed. Together, these results indicate that the aligned collagen-NP composite fiber induced the tenogenic differentiation of ADSCs through both a topographic cue (aligned collagen fibril) and a chemical cue (PDGF released from NPs). Thus, our novel aligned collagen-NP composite fiber has a significant potential to be used for tendon tissue engineering and regeneration. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Cheng, XingGuo; Tsao, Christopher] SW Res Inst, Microencapsulat & Nanomat Dept, San Antonio, TX 78238 USA. [Sylvia, Victor L.; Cornet, Douglas] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthoped, San Antonio, TX 78229 USA. [Nicolella, Daniel P.; Bredbenner, Todd L.] SW Res Inst, Dept Mat Engn, San Antonio, TX 78238 USA. [Christy, Robert J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Program, Ft Sam Houston, TX 78234 USA. RP Cheng, XG (reprint author), SW Res Inst, Microencapsulat & Nanomat Dept, 6220 Culebra Rd, San Antonio, TX 78238 USA. EM xcheng@swri.org FU US Army Med Research ACQ Activity [W81XWH-10-1-0986] FX This work is supported by funding from the US Army Med Research ACQ Activity (Contract No. W81XWH-10-1-0986). The authors also acknowledged help from John P. Salcido for editing and grammar checking of this manuscript. NR 34 TC 19 Z9 19 U1 8 U2 40 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD MAR PY 2014 VL 10 IS 3 BP 1360 EP 1369 DI 10.1016/j.actbio.2013.11.017 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AB3AO UT WOS:000331663900030 PM 24291329 ER PT J AU Martin, NAJ Lundy, JB Rickard, RF AF Martin, Niall A. J. Lundy, Jonathan B. Rickard, Rory F. TI Lack of precision of burn surface area calculation by UK Armed Forces medical personnel SO BURNS LA English DT Article DE Burn wound mapping; Military burns; Precision; Accuracy ID FLUID RESUSCITATION; HAND; CASUALTIES; SIZE; EMERGENCY; RULE; UNIT AB Objective: Accurate determination of the severity of burn is essential for the care of thermally injured patients. We aimed to examine the accuracy and precision of TBSA calculation performed by specialist military burn care providers and non-specialist but experienced military clinicians. Methods: Using a single case example with photographic montages and a modified Lund and Browder chart, the two cohorts of clinicians were each given 10 min to map and calculate the case example TBSA involvement. The accuracy and precision of results from the two cohorts were compared to a set standard %TBSA. Results: The set standard %TBSA involvement was 64.5%. Mean %TBSA mapped by non-specialists (52.53 +/- 10.03%) differed significantly from the set standard (p < 0.0001). No difference was observed when comparing results from the burn care providers (65.68 +/- 10.29%; p = 0.622). However, when comparing precision of calculation of TBSA burned, there was no evidence of a difference in heterogeneity of results between the two cohorts (F test, p = 0.639; Levene's test, p = 0.448). Conclusions: These results indicate that experienced military burn care providers overall more accurately assess %TBSA burned than relatively inexperienced clinicians. However, results demonstrate a lack of precision in both groups. Crown Copyright (C) 2013 Published by Elsevier Ltd and ISBI. All rights reserved. C1 [Martin, Niall A. J.; Rickard, Rory F.] Derriford Hosp, Dept Plast & Reconstruct Surg, Plymouth PL6 8DH, Devon, England. [Lundy, Jonathan B.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Rickard, Rory F.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. RP Rickard, RF (reprint author), Derriford Hosp, Dept Plast Surg, Plymouth PL6 8DH, Devon, England. EM roryrickard@nhs.net NR 39 TC 8 Z9 8 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD MAR PY 2014 VL 40 IS 2 BP 246 EP 250 DI 10.1016/j.burns.2013.05.009 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AB5TL UT WOS:000331851500010 PM 23790587 ER PT J AU Kaminski, RW Wu, M Turbyfill, KR Clarkson, K Tai, B Bourgeois, AL Van De Verg, LL Walker, RI Oaks, EV AF Kaminski, R. W. Wu, M. Turbyfill, K. R. Clarkson, K. Tai, B. Bourgeois, A. L. Van De Verg, L. L. Walker, R. I. Oaks, E. V. TI Development and Preclinical Evaluation of a Trivalent, Formalin-Inactivated Shigella Whole-Cell Vaccine SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID INVASION PLASMID ANTIGENS; FLEXNERI 2A; CROSS-PROTECTION; DEVELOPING-COUNTRIES; IMMUNE-RESPONSE; ANIMAL-MODEL; ETEC VACCINE; EFFICACY; IMMUNOGENICITY; CHILDREN AB Studies were undertaken to manufacture a multivalent Shigella inactivated whole-cell vaccine that is safe, effective, and inexpensive. By using several formalin concentrations, temperatures, and incubation periods, an optimized set of inactivation conditions was established for Shigella flexneri 2a, S. sonnei, and S. flexneri 3a to produce inactivated whole cells expressing a full repertoire of Ipa proteins and lipopolysaccharide (LPS). The inactivation conditions selected were treatment with 0.2% formalin (S. flexneri 2a and 3a) or 0.6% formalin (S. sonnei) for 48 h at 25 degrees C. Vaccine formulations prepared under different inactivation conditions, in different doses (10E5, 10E7, and 10E9 cells), and with or without the inclusion of double-mutant heat-labile toxin (dmLT) were evaluated in mice. Two intranasal immunizations with >= 10E7 inactivated whole cells resulted in high levels of anti-Invaplex and moderate levels of LPS-specific IgG and IgA in serum and in lung and intestinal wash samples. Addition of dmLT to the vaccine formulations did not significantly enhance humoral immunogenicity. Minimal humoral responses for IpaB, IpaC, or IpaD were detected after immunization with inactivated whole Shigella cells regardless of the vaccine inactivation conditions. In guinea pigs, monovalent formulations of S. flexneri 2a of 3a or S. sonnei consisting of 10E8, 10E9, or 10E10 cells were protective in a keratoconjunctivitis assay. A trivalent formulation provided protection against all three serotypes (S. flexneri 2a, P = 0.018; S. flexneri 3a, P = 0.04; S. sonnei, P < 0.0001). The inactivated Shigella whole-cell vaccine approach incorporates an uncomplicated manufacturing process that is compatible with multivalency and the future development of a broadly protective Shigella vaccine. C1 [Kaminski, R. W.; Wu, M.; Turbyfill, K. R.; Clarkson, K.; Tai, B.; Oaks, E. V.] Walter Reed Army Inst Res, Dept Subunit Enter Vaccines & Immunol, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Bourgeois, A. L.; Van De Verg, L. L.; Walker, R. I.] PATH, Enter Vaccine Initiat, Washington, DC USA. RP Oaks, EV (reprint author), Walter Reed Army Inst Res, Dept Subunit Enter Vaccines & Immunol, Bacterial Dis Branch, Silver Spring, MD 20910 USA. EM Edwin.V.Oaks.civ@mail.mil FU PATH through a Cooperative Research and Development Agreement [W81WWH:10-0121]; Walter Reed Army Institute of Research FX This work was supported by PATH through a Cooperative Research and Development Agreement (W81WWH:10-0121) with the Walter Reed Army Institute of Research. NR 44 TC 7 Z9 7 U1 4 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAR PY 2014 VL 21 IS 3 BP 366 EP 382 DI 10.1128/CVI.00683-13 PG 17 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AB8JT UT WOS:000332036900014 PM 24403527 ER PT J AU Penezina, O Krueger, NX Rodriguez-Chavez, IR Busch, MP Hural, J Kim, JH O'Connell, RJ Hunter, E Aboud, S Higgins, K Kovalenko, V Clapham, D Crane, D Levin, AE AF Penezina, Oksana Krueger, Neil X. Rodriguez-Chavez, Isaac R. Busch, Michael P. Hural, John Kim, Jerome H. O'Connell, Robert J. Hunter, Eric Aboud, Said Higgins, Keith Kovalenko, Victor Clapham, David Crane, David Levin, Andrew E. CA HIV Selectest Study Grp TI Performance of a Redesigned HIV Selectest Enzyme-Linked Immunosorbent Assay Optimized To Minimize Vaccine-Induced Seropositivity in HIV Vaccine Trial Participants SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID T-CELL RESPONSES; EFFICACY TRIAL; DIFFERENTIAL-DIAGNOSIS; GENERATED ANTIBODIES; INFECTION; VOLUNTEERS; IMMUNOGENICITY; COMBINATION; RECIPIENTS; THAILAND AB Vaccine-induced seropositivity (VISP) or seroreactivity (VISR), defined as the reaction of antibodies elicited by HIV vaccines with antigens used in HIV diagnostic immunoassays, can result in reactive assay results for vaccinated but uninfected individuals, with subsequent misclassification of their infection status. The eventual licensure of a vaccine will magnify this issue and calls for the development of mitigating solutions in advance. An immunoassay that discriminates between antibodies elicited by vaccine antigens and those elicited by infection has been developed to address this laboratory testing need. The HIV Selectest is based on consensus and clade-specific HIV peptides that are omitted in many HIV vaccine constructs. The assay was redesigned to enhance performance across worldwide clades and to simplify routine use via a standard kit format. The redesigned assay was evaluated with sera from vaccine trial participants, HIV-infected and uninfected individuals, and healthy controls. The HIV Selectest exhibited specificities of 99.5% with sera from uninfected recipients of 6 different HIV vaccines and 100% with sera from normal donors, while detecting HIV-1 infections, including intercurrent infections, with 95 to 100% sensitivity depending on the clade, with the highest sensitivities for clades A and C. HIV Selectest sensitivity decreased in very early seroconversion specimens, which possibly explains the slightly lower sensitivity observed for asymptomatic blood donors than for clinical HIV cases. Thus, the HIV Selectest provides a new laboratory tool for use in vaccine settings to distinguish the immune response to HIV vaccine antigens from that due to true infection. C1 [Penezina, Oksana; Krueger, Neil X.; Kovalenko, Victor; Clapham, David; Crane, David; Levin, Andrew E.] Immunetics Inc, Boston, MA 02210 USA. [Rodriguez-Chavez, Isaac R.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA. [Busch, Michael P.] Blood Syst Res Inst, San Francisco, CA USA. [Hural, John] HIV Vaccine Trials Network, Seattle, WA USA. [Hural, John] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kim, Jerome H.; O'Connell, Robert J.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [O'Connell, Robert J.] USAMC AFRIMS, Bangkok, Thailand. [Hunter, Eric] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [Aboud, Said] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Higgins, Keith] Global Solut Infect Dis, San Francisco, CA USA. RP Levin, AE (reprint author), Immunetics Inc, Boston, MA 02210 USA. EM alevin@immunetics.com FU Westat, Inc. [8067-S04]; National Heart, Lung, and Blood Institute [HHSN268200417175C] FX This project was supported by subcontract 8067-S04 from Westat, Inc., under Retrovirus Epidemiology Donor Study II, which was supported by National Heart, Lung, and Blood Institute contract HHSN268200417175C. NR 34 TC 3 Z9 3 U1 3 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAR PY 2014 VL 21 IS 3 BP 391 EP 398 DI 10.1128/CVI.00748-13 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AB8JT UT WOS:000332036900016 PM 24403525 ER PT J AU Williams, R Larson, NS Pinsker, JE AF Williams, Regina Larson, Noelle S. Pinsker, Jordan E. TI Occult pyogenic liver abscess in an adolescent with type 2 diabetes SO ENDOCRINE LA English DT Editorial Material DE Adolescent; Diabetes; Fever of unknown origin; Kehr's sign; Klebsiella pneumoniae; Liver abscess ID KLEBSIELLA-PNEUMONIAE AB Pyogenic liver abscess is a rare complication of diabetes, usually seen in adults greater than 50 years of age who have had diabetes for many years. We describe an 18-year-old male with type 2 diabetes found to have a pyogenic liver abscess caused by Klebsiella pneumoniae, and show accompanying images from his evaluation for fever of unknown origin (FUO). We conclude that in a child or adolescent with FUO and diabetes, occult pyogenic liver abscess must be considered. C1 [Williams, Regina; Larson, Noelle S.; Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Honolulu, HI 96859 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 3 TC 1 Z9 1 U1 1 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1355-008X EI 1559-0100 J9 ENDOCRINE JI Endocrine PD MAR PY 2014 VL 45 IS 2 BP 335 EP 336 DI 10.1007/s12020-013-0036-6 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AB2RE UT WOS:000331639000025 PM 23949897 ER PT J AU Berkowitz, J Summers, E Noble, C White, J DeLaune, R AF Berkowitz, Jacob F. Summers, Elizabeth A. Noble, Chris V. White, John R. DeLaune, Ronald D. TI Investigation of Biogeochemical Functional Proxies in Headwater Streams Across a Range of Channel and Catchment Alterations SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Biogeochemical function proxy; Headwater stream; Rapid assessment; Riparian zone; Mountain top mining; Valley fill ID LEAF-LITTER DECOMPOSITION; DISSOLVED ORGANIC-CARBON; LAND-USE CHANGE; WATER-QUALITY; NITROGEN FLUXES; UNITED-STATES; FOREST STREAM; WEST-VIRGINIA; NUTRIENT; ECOSYSTEM AB Historically, headwater streams received limited protection and were subjected to extensive alteration from logging, farming, mining, and development activities. Despite these alterations, headwater streams provide essential ecological functions. This study examines proxy measures of biogeochemical function across a range of catchment alterations by tracking nutrient cycling (i.e., inputs, processing, and stream loading) with leaf litter fall, leaf litter decomposition, and water quality parameters. Nutrient input and processing remained highest in second growth forests (the least altered areas within the region), while recently altered locations transported higher loads of nutrients, sediments, and conductivity. Biogeochemical functional proxies of C and N input and processing significantly, positively correlated with rapid assessment results (Pearson coefficient = 0.67-0.81; P = 0.002-0.016). Additionally, stream loading equations demonstrate that N and P transport, sediment, and specific conductivity negatively correlated with rapid assessment scores (Pearson coefficient = 0.56-0.81; P = 0.002-0.048). The observed increase in stream loading with lower rapid assessment scores indicates that catchment alterations impact stream chemistry and that rapid assessments provide useful proxy measures of function in headwater ecosystems. Significant differences in nutrient processing, stream loading, water quality, and rapid assessment results were also observed between recently altered (e.g., mined) headwater streams and older forested catchments (Mann-Whitney U = 24; P = 0.01-0.024). Findings demonstrate that biogeochemical function is reduced in altered catchments, and rapid assessment scores respond to a combination of alteration type and recovery time. An analysis examining time and economic requirements of proxy measurements highlights the benefits of rapid assessment methods in evaluating biogeochemical functions. C1 [Berkowitz, Jacob F.; Summers, Elizabeth A.; Noble, Chris V.] US Army Corps Engineers, Engn Res & Dev Ctr, Wetlands & Coastal Ecol Branch, Vicksburg, MS 39180 USA. [Berkowitz, Jacob F.; White, John R.; DeLaune, Ronald D.] Louisiana State Univ, Dept Oceanog & Coastal Sci, Wetland & Aquat Biogeochem Lab, Baton Rouge, LA 70808 USA. RP Berkowitz, J (reprint author), Louisiana State Univ, Dept Oceanog & Coastal Sci, Wetland & Aquat Biogeochem Lab, 3234 Energy Coast & Environm Bldg, Baton Rouge, LA 70808 USA. EM Jacob.F.Berkowitz@usace.army.mil RI White, John/A-7940-2008 OI White, John/0000-0002-9967-013X FU U.S. Army Corps of Engineers through Wetland Regulatory Assistance program FX This research was funded by the U.S. Army Corps of Engineers through the Wetland Regulatory Assistance program. Thanks to Frank Spilker for extensive field data collection and logistical support from the Huntington and Louisville U.S. Army Corps of Engineers District personnel. Elizabeth Murray, Dr. Nathan Beane, and Dr. Bruce Pruitt provided excellent comments on the manuscript. NR 102 TC 0 Z9 0 U1 5 U2 22 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD MAR PY 2014 VL 53 IS 3 BP 534 EP 548 DI 10.1007/s00267-013-0199-1 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA AB7FX UT WOS:000331956000005 PM 24310643 ER PT J AU Zimmerman, JA Sabau, AS Zaeem, MA Tschopp, MA Spearot, DE AF Zimmerman, Jonathan A. Sabau, Adrian S. Zaeem, Mohsen Asle Tschopp, Mark A. Spearot, Douglas E. TI Algorithm Development in Computational Materials Science SO JOM LA English DT Article C1 [Zimmerman, Jonathan A.] Sandia Natl Labs, Mech Mat Dept, Livermore, CA 94550 USA. [Sabau, Adrian S.] Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. [Zaeem, Mohsen Asle] Missouri Univ Sci & Technol, Mat Sci & Engn Dept, Rolla, MO 65409 USA. [Tschopp, Mark A.] US Army Res Lab, Mat & Mfg Sci Div, Adelphi, MD 20783 USA. [Spearot, Douglas E.] Univ Arkansas, Dept Mech Engn, Fayetteville, AR 72701 USA. RP Zimmerman, JA (reprint author), Sandia Natl Labs, Mech Mat Dept, Livermore, CA 94550 USA. EM jzimmer@sandia.gov RI Sabau, Adrian/B-9571-2008; Tschopp, Mark/B-1594-2008 OI Sabau, Adrian/0000-0003-3088-6474; Tschopp, Mark/0000-0001-8471-5035 NR 6 TC 0 Z9 0 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD MAR PY 2014 VL 66 IS 3 BP 397 EP 398 DI 10.1007/s11837-013-0846-2 PG 2 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA AB9BM UT WOS:000332084100005 ER PT J AU Al-Chaar, G Hoang, T Dowds, D Ford, K Carlson, T Marsh, C AF Al-Chaar, Ghassan Tuan Hoang Dowds, Dominick Ford, Kyle Carlson, Thomas Marsh, Charles TI Temperature Dependence of the Emission Spectrum of Silicon Nanoparticles in Acetone and Isopropanol Solvents SO JOURNAL OF CLUSTER SCIENCE LA English DT Article DE Silicon nanoparticles; Fluorescence; Temperature effects; Environmental conditions AB This study investigated the emission spectra of select silicon nanoparticles when subjected to various temperature changes. Two sizes of silicon nanoparticles, dispersed in both isopropanol and acetone solvents, were studied. Photoluminescence responses of the samples were measured in an environmental chamber that allowed exposure to temperatures in the range of -73 to 65 A degrees C (-100 to 150 A degrees F). These silicon nanoparticles exhibited emission dependence on the temperature of their environment. The emission become brighter as the temperature decreased and less intense as the temperature increased. Thus, the response of these silicon nanoparticles in a harsh environment has been qualified. C1 [Al-Chaar, Ghassan; Tuan Hoang; Dowds, Dominick; Ford, Kyle; Carlson, Thomas; Marsh, Charles] US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61826 USA. [Marsh, Charles] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Al-Chaar, G (reprint author), US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61826 USA. EM ghassan.k.al-chaar@usace.army.mil FU EQ/I Basic Research Program [09-47] FX This work was performed by the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) in Champaign, IL, U.S. Army Corps of Engineers. The investigation was made possible through the EQ/I Basic Research Program, Project 09-47: Interfacial Study of Embedded, Novel Fluorescent Silicon Nanoparticles. The authors would like to acknowledge Professor Munir Nayfeh of the Department of Physics, University of Illinois at Urbana Champaign, for participating in numerous dialogues concerning the work reported here and for sharing his knowledge of these silicon nanoparticles. The authors also thank Nassim Ajami for his assistance in conducting the laboratory experiments. NR 28 TC 0 Z9 0 U1 0 U2 10 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-7278 EI 1572-8862 J9 J CLUST SCI JI J. Clust. Sci. PD MAR PY 2014 VL 25 IS 2 BP 559 EP 570 DI 10.1007/s10876-013-0645-5 PG 12 WC Chemistry, Inorganic & Nuclear SC Chemistry GA AB5KI UT WOS:000331826900021 ER PT J AU Studer, MA Smith, AE Lustik, MB Carr, MR AF Studer, Matthew A. Smith, Ashley E. Lustik, Michael B. Carr, Michael R. TI Newborn Pulse Oximetry Screening to Detect Critical Congenital Heart Disease SO JOURNAL OF PEDIATRICS LA English DT Article ID NEW-JERSEY; DIAGNOSIS; DEFECTS; MALFORMATIONS; INFANTS; SURGERY; FORCE AB Objectives To describe current practice and clarify provider opinion in the US with regard to newborn pulse oximetry screening (NPOx) for critical congenital heart disease. Study design An internet-based questionnaire was forwarded to general pediatricians, neonatologists, and family medicine physicians. Physicians were surveyed regarding involvement in newborn medicine, knowledge of NPOx recommendations, and opinions regarding screening. NPOx protocol specifics were also queried. Results Survey responses (n = 481) were received with 349 respondents involved in newborn medicine. Forty-nine percent (95% CI 44%-54%) of those involved in newborn medicine practice at a hospital with a NPOx protocol. Sixty-six percent of providers endorsed it as an effective tool, 20% required more education, 11% questioned its sensitivity, and 3% had no opinion. Sixty-five percent of providers were aware of recent state legislation mandating its use and 46% reported awareness of the addition of NPOx to the Recommended Uniform Screening Panel. Eighty-four percent of providers who practice at a hospital without a NPOx protocol were interested in its implementation. NPOx protocols varied and were not uniform with differences in time of test, location of probe, and values considered positive. Conclusions NPOx has grown in its prevalence and acceptance in clinical practice, yet is far from universal in its application and design despite the recent American Academy of Pediatrics endorsement and its addition to the Recommended Uniform Screening Panel. The majority of physicians involved in newborn medicine deemed it an effective tool. C1 [Studer, Matthew A.; Smith, Ashley E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Carr, Michael R.] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Chicago, IL 60611 USA. RP Studer, MA (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM matthew.a.studer.mil@mail.mil NR 32 TC 4 Z9 4 U1 1 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAR PY 2014 VL 164 IS 3 BP 505 EP + DI 10.1016/j.jpeds.2013.10.065 PG 7 WC Pediatrics SC Pediatrics GA AB1GI UT WOS:000331539100016 PM 24315501 ER PT J AU Torres, LN Spiess, BD Filho, IPT AF Torres, Luciana N. Spiess, Bruce D. Filho, Ivo P. Torres TI Effects of perfluorocarbon emulsions on microvascular blood flow and oxygen transport in a model of severe arterial gas embolism SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Oxygen delivery; Surfactant; Oxygen transport; Intravital microscopy; Phosphorescence quenching ID SKELETAL-MUSCLE; CARDIOPULMONARY BYPASS; RAT MESENTERY; VOLUMETRIC FLOW; AIR-EMBOLISM; TISSUE; DYNAMICS; BUBBLES; PO2; MICROCIRCULATION AB Background: Arterial gas embolism (AGE) is a clinical problem that occurs directly in cardiopulmonary bypass machines in open-heart surgeries, or indirectly (through cardiac or pulmonary right to left shunts) in dive accidents, resulting in serious morbidity and even death. Perfluorocarbon (PFC) emulsions have been used for the treatment of AGE in an animal model. We hypothesized that PFC emulsions enhance microvascular blood flow, speed bubble resolution, and oxygenation in AGE compared with saline in a model of cremaster muscle from anesthetized rats. Materials and methods: AGE was induced by direct air injection into the femoral artery ipsilateral to the studied cremaster muscle. Microhemodynamics, microvascular, and tissue oxygenation were determined before and after treatment with two different commercial PFC emulsions (C10F20, Oxycyte; Oxygen Biotherapeutics, Inc and C10F18, PHER-O-2; Sanguine Corporation, Inc) compared with saline in real time using brightfield and phosphorescence microscopy. Results: Blood pressure and heart rate remained unchanged. Systemic PO2, oxygen (O-2) content, and glucose were higher in PFC groups, whereas hematocrit dropped in all groups. Arteriolar blood flow went up 85% and 80% of baseline after C10F20 and C10F18 treatments, respectively, versus 11% after saline treatment. Arteriolar and tissue PO2, and O-2 delivery were higher in PFC groups compared with the control group. There was an increase in arteriolar blood flow, reduction in diffusional resistance of O-2 in the plasma, and improved tissue oxygenation. Conclusions: Administration of PFC emulsions in AGE is superior to saline primarily because of surfactant properties along with air bubble reabsorption. Published by Elsevier Inc. C1 [Torres, Luciana N.; Spiess, Bruce D.] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr VCURES, Dept Anesthesiol, Richmond, VA USA. [Torres, Luciana N.; Filho, Ivo P. Torres] US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA. [Spiess, Bruce D.; Filho, Ivo P. Torres] Virginia Commonwealth Univ, Dept Emergency Med, Reanimat Engn Shock Ctr VCURES, Richmond, VA USA. RP Torres, LN (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611,BHT 2,Room 283-1, Ft Sam Houston, TX 78234 USA. EM lntorres0624@yahoo.com FU Office of Naval Research (ONR) [N000140810461]; [ONR: N000140810474]; [N000140810459] FX The authors would like to thank Brian Berger for the help during various phases of the study. Ivo Torres Filho is employed by Premier Consulting and Management Services, Inc and by Universidade do Estado do Rio de Janeiro (UERJ). Luciana Torres was a postdoctoral fellow awarded by the Office of Naval Research (ONR; No. N000140810461) and now is employed by Cherokee Nation Business, Inc. This work was performed at Virginia Commonwealth University and supported by grants from the ONR: N000140810474 and N000140810459. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 48 TC 1 Z9 1 U1 2 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD MAR PY 2014 VL 187 IS 1 BP 324 EP 333 DI 10.1016/j.jss.2013.08.011 PG 10 WC Surgery SC Surgery GA AB2FB UT WOS:000331607500046 PM 24246440 ER PT J AU Sanghavi, BJ Kalambate, PK Karna, SP Srivastava, AK AF Sanghavi, Bankim J. Kalambate, Pramod K. Karna, Shashi P. Srivastava, Ashwini K. TI Voltammetric determination of sumatriptan based on a graphene/gold nanoparticles/Nafion composite modified glassy carbon electrode SO TALANTA LA English DT Article DE Sumatriptan; Graphene; Gold nanoparticles; Electra-reduction; Nafion ID POTENTIOMETRIC STRIPPING ANALYSIS; PASTE ELECTRODE; ELECTROCHEMICAL-BEHAVIOR; LIQUID-CHROMATOGRAPHY; COPPER(II) COMPLEX; BIOMIMETIC SENSOR; CHEMICAL SENSORS; HUMAN PLASMA; NANOTUBE; OXIDE AB A mixture of graphene oxide and tetrachloroauric acid was electrochemically co-reduced directly on a glassy carbon electrode (GCE) surface via cyclic voltammetry so as to form a graphene (Gr)-gold nanoparticles (AuNP) composite. This nanocomposite was then coated with nafion (NAF) film so as to form Gr/AuNP/NAF/GCE. Sumatriptan (SUM) is a drug belonging to the triptan class, used for the treatment of migraine headaches. In this work, an electrochemical method based on the adsorptive stripping differential pulse voltammetry (AdSDPV) employing Gr/AuNP/NAF/GCE has been proposed for the subnanomolar determination of SUM. Characterization of the electrode material has been carried out by UV-visible spectrophotometry, X-ray diffraction and scanning electron microscopy. Also the electrode surface has been characterized by means of cyclic voltammetry, electrochemical impedance spectroscopy, chronocoulometry. By employing Gr/AuNP/NAF/GCE at pH 7.0 phosphate buffer, a 20-fold enhancement in the AdSDPV signal was observed as compared to GCE. Under the optimized conditions, I-p (mu A) was proportional to the SUM concentration in the range of 1.0 x 10(-6)-4.12 x 10(-5) M (R-2=0.9991) and 2.14 x 10(-9)-1.0 x 10(6) (R-2=0.9954) with a detection limit (3 x SD/s) of 7.03 x 10(-10) M. The practical analytical utilities of the modified electrode were demonstrated by the determination of SUM in pharmaceutical formulations, human urine and blood serum samples. This proposed method was validated by HPLC and the results are in agreement at the 95% confidence level. (C) 2013 Elsevier B.V. All rights reserved. C1 [Sanghavi, Bankim J.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Kalambate, Pramod K.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] US Army, Res Lab, ATTN, RDRL WM,Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU University Grants Comission, New Delhi, India; US Army International Technology Center, Tokyo, Japan [FA2386-12-1-4086] FX The funding for this work is partly by the University Grants Comission, New Delhi, India and partly by the US Army International Technology Center, Tokyo, Japan through contract number FA2386-12-1-4086. NR 45 TC 53 Z9 54 U1 11 U2 113 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 EI 1873-3573 J9 TALANTA JI Talanta PD MAR PY 2014 VL 120 BP 1 EP 9 DI 10.1016/j.talanta.2013.11.077 PG 9 WC Chemistry, Analytical SC Chemistry GA AB6RR UT WOS:000331917700001 PM 24468334 ER PT J AU Darling, KA Tschopp, MA VanLeeuwen, BK Atwater, MA Liu, ZK AF Darling, K. A. Tschopp, M. A. VanLeeuwen, B. K. Atwater, M. A. Liu, Z. K. TI Mitigating grain growth in binary nanocrystalline alloys through solute selection based on thermodynamic stability maps SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Nanocrystalline materials; Grain growth; Grain boundary energy; Grain boundary segregation ID 5 MACROSCOPIC PARAMETERS; ATOM-PROBE TOMOGRAPHY; THERMAL-STABILITY; BOUNDARY SEGREGATION; MECHANICAL-BEHAVIOR; SURFACE-ENERGY; COPPER; STABILIZATION; METALS; ADDITIONS AB Mitigating grain growth at high temperatures in binary nanocrystalline alloys is important for processing nanocrystalline alloy systems. The objective of this research is to develop a methodical design-based approach for selecting solutes in binary nanocrystalline alloys by revisiting grain boundary thermodynamics and the internal processes of grain growth and solute segregation in a closed system. In this work, the grain boundary energy is derived and systematically studied in terms of temperature, grain size, concentration, and solute segregation for binary systems of 44 solvents and 52 solutes, using readily-available elemental data, such as moduli and liquid enthalpy of mixing. It is shown that through solute segregation, the grain boundary energies of some binary systems can be reduced, resulting in thermodynamically stable grain structures and successful prediction of solutes that inhibit grain growth in some nanocrystalline alloys. Parametric studies reveal trends between equilibrium grain size, solute distribution and temperature for various binary systems culminating in the generation of nanocrystalline thermodynamic stability maps as a tool for solute selection in binary nanocrystalline alloys. Published by Elsevier B.V. C1 [Darling, K. A.; Tschopp, M. A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [VanLeeuwen, B. K.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Atwater, M. A.] Millersville Univ Pennsylvania, Appl Engn Safety & Technol Dept, Millersville, PA 17551 USA. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kristopher.darling.civ@mail.mil; mark.tschopp@gatech.edu RI Tschopp, Mark/B-1594-2008; Liu, Zi-Kui/A-8196-2009 OI Tschopp, Mark/0000-0001-8471-5035; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Laboratory (ARL) [GS04T09DBC0017]; ARL; National Science Foundation [DMR-1005677] FX This work is supported in part by the U.S. Army Research Laboratory (ARL) under contract GS04T09DBC0017. Dr. Mark Tschopp would like to acknowledge partial support from ARL administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and ARL. Dr. Mark Tschopp would like to acknowledge continued support for this work from ARL through the High Performance Technology Group at Dynamic Research Corporation. Dr. Zi-Kui Liu would like to acknowledge support from the National Science Foundation under Grant DMR-1005677. NR 69 TC 21 Z9 21 U1 9 U2 59 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD MAR PY 2014 VL 84 BP 255 EP 266 DI 10.1016/j.commatsci.2013.10.018 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA AA4SN UT WOS:000331086500032 ER PT J AU Stanley, JK Biedenbach, JM Russell, AL Bednar, AJ AF Stanley, Jacob K. Biedenbach, James M. Russell, Amber L. Bednar, Anthony J. TI Algal growth stimulation and toxicity in response to exposure to the new insensitive military high-nitrogen energetic triaminoguanidinium-1-methyl-5-nitriminotetrazolate SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Energetic compounds; Growth; Triaminoguanidinium-1-methyl-5-nitriminotetrazolate; Stimulation; Algae ID ECOTOXICITY CHARACTERIZATION; FRESH-WATER; ECOSYSTEMS; RICH AB Triaminoguanidinium-1-methyl-5-nitriminotetrazolate (TAG-MNT) is a nitrogen-rich energetic compound being developed as a potential component of insensitive munition formulations. The purpose of the present study was to assess the toxicity of TAG-MNT to the green alga Pseudokirchneriella subcapitata as well as to determine whether the high N content of TAG-MNT could result in increased algal growth in aquatic systems and potentially contribute to eutrophication using a 96-h algal growth bioassay in N-limited test media. Results were compared with algal exposures to current-use energetics 2,4,6-trinitrotoluene (TNT) and royal demolition explosive (RDX). The TNT exposure resulted in a lowest-observed-adverse-effect concentration (LOAEC) for algal growth of 1.72 mg/L and a 50% inhibition concentration (IC50) and 95% confidence limits of 0.972 mg/L (0.955, 0.973). The RDX algal growth LOAEC was 0.10 mg/L, and the RDX IC50 was 0.635 (0.416, 0.875). Neither TNT nor RDX exposure resulted in stimulation of algal growth. In repeated testing, TAG-MNT exposure resulted in LOAECs of 0.55 and 5.20 mg/L. Stimulation of algal growth was observed at 0.06 mg/L at a mean increase of 163.2% (+/- 71.7) relative to the control in TAG-MNT test A and at the 0.005 mg/L treatment at a mean increase of 174.3% (+/- 59.9) in TAG-MNT test B. The authors' results indicate the potential for high-N energetics to significantly stimulate algal growth at low concentrations in N-limited systems. Environ Toxicol Chem 2014;33:616-620. (c) 2013 SETAC. This article is a US Government work and is in the public domain in the USA. C1 [Stanley, Jacob K.; Biedenbach, James M.; Russell, Amber L.; Bednar, Anthony J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM jacob.k.stanley@us.army.mil FU Army's Environmental Quality Technology Basic Research Program FX Permission was granted by the Chief of Engineers to publish this material. This work was supported by the Army's Environmental Quality Technology Basic Research Program (E. Ferguson, Technical Director). The authors thank R. Damavarapu of the US Army Armament Research, Development and Engineering Center for synthesis of triaminoguanidinium-1-methyl-5-nitriminotetrazolate. NR 19 TC 0 Z9 0 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2014 VL 33 IS 3 BP 616 EP 620 DI 10.1002/etc.2473 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AA8HA UT WOS:000331335000019 PM 24464919 ER PT J AU Wright, KM Foran, HM Wood, MD AF Wright, Kathleen M. Foran, Heather M. Wood, Michael D. TI COMMUNITY NEEDS AMONG SERVICE MEMBERS AFTER RETURN FROM COMBAT DEPLOYMENT SO JOURNAL OF COMMUNITY PSYCHOLOGY LA English DT Article ID MENTAL-HEALTH PROBLEMS; MILITARY FAMILIES; SUPPORT; ADAPTATION; CHECKLIST; EDUCATION; SYMPTOMS; MARRIAGE; IRAQ; CARE AB To build on research concerning the development of postdeployment community-based programs, we surveyed active duty soldiers from two Brigade Combat Teams (N = 693; N = 1,385) after return from a combat deployment. The Brigade Combat Teams were located on different installations in rural areas representing 2 large military communities. The survey included an assessment about a range of community services (social events, cultural integration opportunities, family, chaplain, and mental health services, etc.). We also examined whether ratings of services varied as a function of Posttraumatic Stress Disorder symptoms, deployment experiences, organizational leadership and support, and attitudinal variables related to mental health. Differences in ratings between the 2 communities suggest the measure detected perceptions of community needs that are idiosyncratic to the particular community, and may be useful for informing program planning and service needs. C1 [Wright, Kathleen M.; Foran, Heather M.; Wood, Michael D.] Walter Reed Army Inst Res, D-69126 Heidelberg, Germany. RP Wright, KM (reprint author), Walter Reed Army Inst Res, US Army Med Res Unit Europe, Karlsruher Str 144, D-69126 Heidelberg, Germany. EM kathleen.m.wright4.civ@mail.mil NR 31 TC 1 Z9 1 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0090-4392 EI 1520-6629 J9 J COMMUNITY PSYCHOL JI J. Community Psychol. PD MAR PY 2014 VL 42 IS 2 BP 127 EP 142 DI 10.1002/jcop.21598 PG 16 WC Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Social Work SC Public, Environmental & Occupational Health; Psychology; Social Work GA AA5HL UT WOS:000331126600001 ER PT J AU Forshey, BM Castillo, RM Hang, J AF Forshey, Brett M. Castillo, Roger M. Hang, Jun TI Group C Orthobunyavirus Genomic Sequences Require Validation SO JOURNAL OF VIROLOGY LA English DT Letter ID IDENTIFICATION; BUNYAVIRIDAE; VIRUSES; AMERICA C1 [Forshey, Brett M.; Castillo, Roger M.] US Naval Med Res Unit 6, Lima, Peru. [Hang, Jun] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Forshey, BM (reprint author), US Naval Med Res Unit 6, Lima, Peru. EM brett.forshey@gmail.com NR 6 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD MAR PY 2014 VL 88 IS 5 BP 3052 EP 3053 DI 10.1128/JVI.03295-13 PG 2 WC Virology SC Virology GA AA5JK UT WOS:000331131700062 PM 24505105 ER PT J AU Hudspeth, M Agarwal, A Andrews, B Claus, B Hai, F Funnell, C Zheng, J Chen, WN AF Hudspeth, Matthew Agarwal, Apaar Andrews, Beck Claus, Ben Hai, Feng Funnell, Curtis Zheng, James Chen, Weinong TI Degradation of yarns recovered from soft-armor targets subjected to multiple ballistic impacts SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Aramid fiber; Yarn; Fabrics/textiles; Impact behavior ID STATISTICAL VARIABILITY; STRENGTH; FIBERS; STRAIN; BUNDLES; FAILURE AB Post ballistic impact residual yarn mechanical properties were analyzed from two different as-received shoot packs composed solely of AuTx yarn possessing the 2/2 twill weave structure, one being impacted by 9-mm projectiles and the other by 2-grain projectiles. It was found that yarn mechanical properties from both shoot packs yielded similar results, regardless of yarn orientation, ply location, or penetrator size, which indicates that ballistic damage in the packets is very localized, producing little damage to the neighboring yarns. Mechanical properties of these woven, ballistically impacted, and then extracted yarns were compared to as-received native spooled AuTx yarn yielding a slight reduction in tensile strength, an increase in failure strain, and a reduction in elastic modulus, thereby yielding little variation in yarn toughness. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hudspeth, Matthew; Claus, Ben; Hai, Feng; Funnell, Curtis; Chen, Weinong] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. [Agarwal, Apaar] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. [Andrews, Beck; Chen, Weinong] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Zheng, James] US Army, Program Execut Off Soldier, Ft Belvoir, VA USA. RP Chen, WN (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu FU US ARMY PEO Soldier program; NDSEG FX This research was supported by the US ARMY PEO Soldier program. The first author would also like to thank the NDSEG fellowship for graduate research funding. NR 33 TC 3 Z9 3 U1 2 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD MAR PY 2014 VL 58 BP 98 EP 106 DI 10.1016/j.compositesa.2013.12.004 PG 9 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA AA5TG UT WOS:000331161900014 ER PT J AU Hu, JC Liu, CH Treat, EG Ernest, A Veale, J Carter, S Huang, KH Blumberg, JM Schulam, PG Gritsch, HA AF Hu, Jim C. Liu, Chia-Hung Treat, Eric G. Ernest, Alexander Veale, Jeffrey Carter, Stacey Huang, Kuo-How Blumberg, Jeremy M. Schulam, Peter G. Gritsch, Hans A. TI Determinants of Laparoscopic Donor Nephrectomy Outcomes SO EUROPEAN UROLOGY LA English DT Article DE Donor nephrectomy; Laparoscopy; Complication; Outcomes ID MULTIPLE RENAL-ARTERIES; LIVING KIDNEY DONORS; LIVE DONOR; URETERAL COMPLICATIONS; EXPERIENCE; TRANSPLANTATION; DONATION; VASCULATURE; RECIPIENT; OLDER AB Background: Pure laparoscopic donor nephrectomy (LDN) is a unique intervention because it carries known risks and complications, yet carries no direct benefit to the donor. Therefore, it is critical to continually examine and improve quality of care. Objective: To identify factors affecting LDN outcomes and complications. Design, setting, and participants: A retrospective analysis of prospectively collected data for 1204 consecutive LDNs performed from March 2000 through August 2012. Intervention: LDN performed at an academic training center. Outcome measurements and statistical analysis: Using multivariable regression, we assessed the effect of age, sex, body mass index (BMI), laterality, and vascular variation on operative time, estimated blood loss (EBL), complications, and length of stay. Results and limitations: The following variables were associated with longer operative time (data given as parameter estimate plus or minus the standard error): female sex (9.09 +/- 2.43; p < 0.001), higher BMI (1.03 +/- 0.32; p = 0.001), two (7.87 +/- 2.70; p = 0.004) and three or more (22.45 +/- 7.13; p = 0.002) versus one renal artery, and early renal arterial branching (5.67 +/- 2.82; p = 0.045), while early renal arterial branching (7.81 +/- 3.85; p = 0.043) was associated with higher EBL. Overall, 8.2% of LDNs experienced complications, and by modified Clavien classification, 74 (5.9%) were grade 1, 13 (1.1%) were grade 2a, 10 (0.8%) were grade 2b, and 2 (0.2%) were grade 2c. There were no grade 3 or 4 complications. Three or more renal arteries (odds ratio [OR]: 2.74; 95% CI, 1.05-7.16; p = 0.04) and late renal vein confluence (OR: 2.42; 95% CI, 1.50-3.91; p = 0.0003) were associated with more complications. Finally, we did not find an association of the independent variables with length of stay. A limitation is that warm ischemia time was not assessed. Conclusions: In our series, renal vascular variation prolonged operative time and was associated with more complications. While complicated donor anatomy is not a contraindication of LDN, surgical decision-making should take into consideration these results. (C) 2013 Published by Elsevier B.V. on behalf of European Association of Urology. C1 [Hu, Jim C.; Liu, Chia-Hung; Treat, Eric G.; Veale, Jeffrey; Carter, Stacey; Huang, Kuo-How; Blumberg, Jeremy M.; Gritsch, Hans A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA 90024 USA. [Ernest, Alexander] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Schulam, Peter G.] Yale Univ, Sch Med, Dept Urol, New Haven, CT USA. RP Hu, JC (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, 924 Westwood Blvd,Ste 1000, Los Angeles, CA 90024 USA. EM jchu@mednet.ucla.edu OI Huang, Kuo-How/0000-0002-0989-0578 NR 29 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0302-2838 EI 1873-7560 J9 EUR UROL JI Eur. Urol. PD MAR PY 2014 VL 65 IS 3 BP 659 EP 664 DI 10.1016/j.eururo.2013.09.048 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 302AC UT WOS:000330572600030 PM 24139942 ER PT J AU Caras, RJ Lustik, MB Kern, SQ Sterbis, JR McMann, LP AF Caras, Ronald J. Lustik, Michael B. Kern, Sean Q. Sterbis, Joseph R. McMann, Leah P. TI Laparoscopic Radical Prostatectomy Demonstrates Less Morbidity Than Open Radical Prostatectomy: An Analysis of the American College of Surgeons-National Surgical Quality Improvement Program Database with a Focus on Surgical Trainee Involvement SO JOURNAL OF ENDOUROLOGY LA English DT Article ID RETROPUBIC PROSTATECTOMY; RESIDENT INVOLVEMENT; COMPLICATION RATES; OUTCOMES; CANCER; SAMPLE; NSQIP AB Introduction: Complication rates of open radical prostatectomies (ORPs) and laparoscopic radical prostatectomies (LRPs) performed by highly experienced surgeons in centers of excellence are well known. Using a standardized, national, risk-adjusted surgical database, we compared 30-day outcomes following ORP and LRP and analyzed how trainee involvement influenced outcomes. Methods: The American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) is a risk-adjusted data collection analyzing preoperative risk factors, demographics, and 30-day postoperative outcomes. From 2005 to 2011, we identified 10,669 total prostatectomies. Of these, 2278 were ORP and 8391 were LRP. Data on trainee involvement were available on 63% of cases. Results: Comparison of all 10,669 prostatectomies showed a decreased incidence of overall morbidity, serious morbidity, surgical site infections, mortality, wound disruption, urinary tract infection, bleeding, and sepsis or septic shock (p<0.05) for LRP compared with ORP. Trainee involvement was associated with a higher incidence of bleeding, overall and serious morbidity (p<0.001). This difference is isolated to postgraduate year (PGY) 6-10 trainees performing ORP (p<0.001). Overall and serious morbidity was equivalent between PGY groups 1-10 versus attending without trainee performing LRP and PGY groups 1-5 versus attending without trainee performing ORP. Operative times were shorter for ORP versus LRP by an average of 38 minutes (p<0.05), and in cases involving trainees, operative times decreased with trainee experience for both procedures. The length of stay was shorter for LRP compared with ORP (3.2 vs. 1.8 days, p<0.001). Conclusions: The large sample size, standardized data definitions, and quality control measures of the ACS-NSQIP database allow for in-depth analysis of subtle, but significant differences in outcomes between groups. Trainee involvement in LRP appears safe to patients. However, the increased morbidity in ORP involving trainees may be mitigated by awareness, simulation laboratories, and standardized competency assessment. C1 [Caras, Ronald J.; Kern, Sean Q.; Sterbis, Joseph R.; McMann, Leah P.] Tripler Army Med Ctr, Dept Urol, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Caras, RJ (reprint author), Tripler Army Med Ctr, Dept Urol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM rjcaras@gmail.com NR 26 TC 4 Z9 5 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0892-7790 EI 1557-900X J9 J ENDOUROL JI J. Endourol. PD MAR 1 PY 2014 VL 28 IS 3 BP 298 EP 305 DI 10.1089/end.2013.0475 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA AB0CR UT WOS:000331459900006 PM 24164643 ER PT J AU Heiner, JD Morgan, TL AF Heiner, Jason D. Morgan, Trent L. TI Progressive bruising in an otherwise healthy child: immune thrombocytopenia purpura SO CANADIAN JOURNAL OF EMERGENCY MEDICINE LA English DT Editorial Material DE immune thrombocytopenic purpura; pediatrics C1 [Heiner, Jason D.] Univ Washington, Div Emergency Med, Seattle, WA 98195 USA. [Morgan, Trent L.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Heiner, JD (reprint author), Univ Washington, Div Emergency Med, 1959 Northeast Pacific St,Box 356123, Seattle, WA 98195 USA. EM jheiner@uw.edu NR 5 TC 0 Z9 0 U1 1 U2 1 PU DECKER PUBL INC PI HAMILTON PA 69 JOHN ST S, STE 310, HAMILTON, ONTARIO L8N 2B9, CANADA SN 1481-8035 J9 CAN J EMERG MED JI Can. J. Emerg. Med. PD MAR PY 2014 VL 16 IS 2 BP 158 EP 159 DI 10.2310/8000.2013.131044 PG 2 WC Emergency Medicine SC Emergency Medicine GA CA9MU UT WOS:000349249100010 PM 24626122 ER PT J AU Morris, M Skabelund, A Haislip, G Lucero, P AF Morris, Michael Skabelund, Andrew Haislip, Georgette Lucero, Pedro TI Comprehensive Evaluation of Military Personnel With Postdeployment Respiratory Symptoms SO CHEST LA English DT Meeting Abstract C1 [Morris, Michael; Skabelund, Andrew; Haislip, Georgette; Lucero, Pedro] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 3 Z9 3 U1 0 U2 2 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2014 VL 145 IS 3 SU S MA 568A DI 10.1378/chest.1824279 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CV8GF UT WOS:000364518700482 ER PT J AU Oh, A Quast, T AF Oh, Andrew Quast, Timothy TI Central Venous Catheter Appears to Enter the Aorta. Clinically Correlate: A Case of Bilateral Superior Vena Cava SO CHEST LA English DT Meeting Abstract C1 [Oh, Andrew; Quast, Timothy] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2014 VL 145 IS 3 SU S MA 80A DI 10.1378/chest.1803785 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CV8GF UT WOS:000364518700070 ER PT J AU Oh, A Schaffrinna, A AF Oh, Andrew Schaffrinna, Andrew TI Central Venous Catheter Appears to Enter the Aorta. Clinically Correlate: A Case of Left Brachiocephalic Tributary Vein Cannulation SO CHEST LA English DT Meeting Abstract C1 [Oh, Andrew; Schaffrinna, Andrew] Brooke Army Med Ctr, Converse, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2014 VL 145 IS 3 SU S MA 60A DI 10.1378/chest.1825069 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CV8GF UT WOS:000364518700054 ER PT J AU Nelson, JM AF Nelson, Jeffery M. TI Quality Measurement and Improvement in Colon and Rectal Surgery Preface SO CLINICS IN COLON AND RECTAL SURGERY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Nelson, JM (reprint author), Walter Reed Army Med Ctr, Dept Surg, 5900 Georgia Ave NW,Georgia Ave, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1531-0043 EI 1530-9681 J9 CLIN COLON RECT SURG JI Clin. Colon Rectal Surg. PD MAR PY 2014 VL 27 IS 1 BP 3 EP 4 DI 10.1055/s-0034-1366918 PG 2 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA CL3VN UT WOS:000356879400002 PM 24587697 ER PT J AU Kerfoot, WC Hobmeier, MM Yousef, F Green, SA Regis, R Brooks, CN Shuchman, R Anderson, J Reif, M AF Kerfoot, W. Charles Hobmeier, Martin M. Yousef, Foad Green, Sarah A. Regis, Robert Brooks, Colin N. Shuchman, Robert Anderson, Jamey Reif, Molly TI Light Detection and Ranging (LiDAR) and Multispectral Scanner (MSS) Studies Examine Coastal Environments Influenced by Mining SO ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION LA English DT Article DE LiDAR; MSS; mining; coastal; stamp sands ID LAKE-SUPERIOR SEDIMENTS; KEWEENAW PENINSULA; TOXICITY TESTS; COPPER; WATER; MERCURY; MICHIGAN; HURON AB There are numerous examples of past and present mine disposal into freshwater and marine coastal bays and riverine environments. Due to its high spatial resolution and extended water penetration, coastal light detection and ranging (LiDAR), coupled with multispectral scanning (MSS), has great promise for resolving disturbed shoreline features in low turbidity environments. Migrating mine tailings present serious issues for Lake Superior and coastal marine environments. Previous investigations in Lake Superior uncovered a metal-rich "halo" around the Keweenaw Peninsula, related to past copper mining practices. For over a century, waste rock migrating from shoreline tailing piles has moved along extensive stretches of coastline, compromising critical fish breeding grounds, damming stream outlets, transgressing into wetlands and along recreational beaches and suppressing benthic invertebrate communities. In Grand (Big) Traverse Bay, Buffalo Reef is an important spawning area for lake trout and whitefish threatened by drifting tailings. The movement of tailings into Buffalo Reef cobble fields may interfere with the hatching of fish eggs and fry survival, either by filling in crevices where eggs are deposited or by toxic effects on eggs, newly hatched larvae or benthic communities. Here, we show that the coastal tailing migration is not "out of sight, out of mind", but clearly revealed by using a combination of LiDAR and MSS techniques. C1 [Kerfoot, W. Charles; Hobmeier, Martin M.; Yousef, Foad; Green, Sarah A.; Anderson, Jamey] Michigan Technol Univ, Great Lakes Res Ctr, Houghton, MI 49931 USA. [Kerfoot, W. Charles; Hobmeier, Martin M.; Yousef, Foad; Green, Sarah A.; Anderson, Jamey] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. [Green, Sarah A.] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA. [Regis, Robert; Shuchman, Robert] Michigan Technol Univ, Dept Geol & Min Engn & Sci, Houghton, MI 49931 USA. [Brooks, Colin N.; Shuchman, Robert] Michigan Tech Res Inst, Ann Arbor, MI 48105 USA. [Reif, Molly] US Army Corps Engineers Engineer Res & Dev Ctr, Environm Lab, Joint Airborne LiDAR Bathymetry Tech Ctr Expertis, Kiln, MS 39556 USA. RP Kerfoot, WC (reprint author), Michigan Technol Univ, Great Lakes Res Ctr, Houghton, MI 49931 USA. EM wkerfoot@mtu.edu; mmhobmei@mtu.edu; fyousef@mtu.edu; sgreen@mtu.edu; rregis@nmu.edu; cnbrooks@mtu.edu; shuchman@mtu.edu; jameya@mtu.edu; Molly.K.Reif@usace.army.mil OI Green, Sarah/0000-0002-8094-433X FU Army Corps of Engineers ERDC-EL laboratory; System Wide Water Resources Program at Vicksburg; National Science Foundation [OCE 97-12872] FX Primary funding for LiDAR/MSS investigations came from the Army Corps of Engineers ERDC-EL laboratory and was provided by the System Wide Water Resources Program (Steve Ashby) at Vicksburg, MS. Efforts were also aided by a National Science Foundation OCE 97-12872 grant to W. Charles Kerfoot, and a US Environmental Protection Agency Region V Grant to the Baraga Tribal Council passed through to W. Charles Kerfoot Support for the CHARTS flight and initial data processing was provided by the Corps National Coastal Mapping Program managed by Jennifer Wozencraft at the JALBTCX Center. We thank Dave Schwab, NOAA GLERL, Ann Arbor, for assistance on the NOAA LiDAR series overflight and coastal forecast information. We also thank Esteban Chiriboga and especially Hans Biberhofer for sharing the details of the National Water Research Institute and Great Lakes Indian Fish and Wildlife Commission sonar mapping and sediment sampling efforts in Grand (Big) Traverse Bay. We also want to recognize ROV and sampling efforts by Jade Ortiz, Nathan Zgniler, and Aaron Garceau in summer, 2013. Lucille Zelazny proofread the manuscript and aided in preparation of figures. NR 60 TC 1 Z9 1 U1 3 U2 10 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2220-9964 J9 ISPRS INT GEO-INF JI ISPRS Int. Geo-Inf. PD MAR PY 2014 VL 3 IS 1 BP 66 EP 95 DI 10.3390/ijgi3010066 PG 30 WC Geography, Physical; Remote Sensing SC Physical Geography; Remote Sensing GA CO1RK UT WOS:000358932700005 ER PT J AU Wongdamnern, N Maurya, D Zhou, Y Sanghadasa, M Yimnirun, R Priya, S AF Wongdamnern, Natthapong Maurya, Deepam Zhou, Yuan Sanghadasa, Mohan Yimnirun, Rattikorn Priya, Shashank TI Complex permittivity scaling of functionally graded composites SO MATERIALS RESEARCH EXPRESS LA English DT Article DE permittivity; scaling; multilayer; graded structure; ferroelectric AB In this paper, we provide a fundamental understanding of dielectric loss behavior as a function of applied electric field and frequency in functionally graded composites with varying numbers of layers and compositions. A new power-law scaling relation in the form of e '' proportional to f(p)E(o)(q) was derived based upon the ferroelectric hysteresis. The magnitude of the imaginary component of the dielectric permittivity (epsilon '') was estimated from the polarization-electric field hysteresis loop. The changes in exponents of the scaling relation were correlated with the mechanism controlling the dielectric loss and interfacial coupling in graded structures. Building upon the scaling analysis, we investigated the effect of E-field on the domain mobility (mu) for various functionally graded systems. These results were correlated with the experimental investigation on ferroelectric domains using transmission electron microscopy and piezoresponse force microscopy. C1 [Wongdamnern, Natthapong] Rajamangala Univ Technol Suvarnabhumi, Fac Sci & Technol, Dept Phys, Phranakorn Si Ayutthaya 13000, Thailand. [Maurya, Deepam; Zhou, Yuan; Priya, Shashank] Virginia Tech, Ctr Energy Harvesting Mat & Syst, Bioinspired Mat & Devices Lab, Blacksburg, VA 24061 USA. [Sanghadasa, Mohan] US Army RDECOM, Weap Sci Directorate, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Yimnirun, Rattikorn] Suranaree Univ Technol, Sch Phys, Inst Sci, Nakhon Ratchasima 30000, Thailand. [Yimnirun, Rattikorn] NANOTEC SUT Ctr Excellence Adv Funct Nanomat, Nakhon Ratchasima 30000, Thailand. RP Wongdamnern, N (reprint author), Rajamangala Univ Technol Suvarnabhumi, Fac Sci & Technol, Dept Phys, Phranakorn Si Ayutthaya 13000, Thailand. EM mauryad@vt.edu; spriya@vt.edu FU Office of Basic Energy Science, Department of Energy; NSF INAMM program; Fundamental R&D Program for Core Technology of Materials - Ministry of Knowledge Economy, Republic of Korea; NANOTEC-SUT Center of Excellence on Advanced Functional Nanomaterials; Development and Promotion of Science and Technology Talents project (DPST) of the Institute for the Promotion of Teaching Science and Technology (IPST); Faculty of Science and Technology, Rajamangala University of Technology Suvarnabhumi, Thailand FX The authors would like to acknowledge the financial support from the Office of Basic Energy Science, Department of Energy (design of graded ferroelectrics); NSF INAMM program (N W and S P) and Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea (scaling dynamics). One of the authors (RY) expresses gratitude to the NANOTEC-SUT Center of Excellence on Advanced Functional Nanomaterials for support of this study. N W thanks the Development and Promotion of Science and Technology Talents project (DPST) of the Institute for the Promotion of Teaching Science and Technology (IPST), Faculty of Science and Technology, Rajamangala University of Technology Suvarnabhumi, Thailand for support during this study. NR 17 TC 1 Z9 1 U1 1 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1591 J9 MATER RES EXPRESS JI Mater. Res. Express PD MAR PY 2014 VL 1 IS 1 AR 016305 DI 10.1088/2053-1591/1/1/016305 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA V43EQ UT WOS:000209665100105 ER PT J AU Krawczyk, S AF Krawczyk, Scott TI Religious Dissent and the Aikin-Barbauld Circle, 1740-1860. SO RELIGION & LITERATURE LA English DT Book Review C1 [Krawczyk, Scott] US Mil Acad, West Point, NY USA. RP Krawczyk, S (reprint author), US Mil Acad, West Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV NOTRE DAME PI NOTRE DAME PA UNIV NOTRE DAME, 1146 FLANNER HALL, NOTRE DAME, IN 46556 USA SN 0888-3769 J9 RELIG LIT JI Relig. Lit. PD SPR PY 2014 VL 46 IS 1 BP 215 EP 218 PG 4 WC Literature; Religion SC Literature; Religion GA V41XD UT WOS:000209578000020 ER PT J AU Ge, GM Mahmood, GI Moghaddam, DG Simonson, CJ Besant, RW Hanson, S Erb, B Gibson, PW AF Ge, Gaoming Mahmood, Gazi I. Moghaddam, Davood Ghadiri Simonson, Carey J. Besant, Robert W. Hanson, Stephen Erb, Blake Gibson, Phillip W. TI Material properties and measurements for semi-permeable membranes used in energy exchangers SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Semi-permeable membrane; Energy exchanger; Vapor diffusion resistance; Elastic modulus; Measurement ID DESICCANT AIR DEHUMIDIFICATION; RECOVERY VENTILATOR; MASS-TRANSFER; PERFORMANCE ANALYSIS; MOISTURE TRANSFER; SYSTEM; HEAT; DISTILLATION; FABRICS AB Over the past decade, semi permeable membranes that transfer heat and water vapor have been investigated and applied in air-to-air or liquid-to-air energy exchangers. The water vapor diffusion resistance and modulus of elasticity are two of the most important properties of membranes. These properties play significant roles on the design and performance of the membrane based energy exchangers. In this study, measurement test methods for membrane properties are presented and important factors impacting the test results are evaluated using the test data. It is found that operating conditions and crystals or deposits in membranes influence the vapor diffusion resistances. The elastic modulus can be determined from the elastic deflection of a simply supported membrane subject to a normal pressure difference. Deflections of membranes are known to cause mai-distribution of flows in energy exchangers and this degrades their performance. Some effective methods to reduce deflections of membranes are presented. (C) 2013 Elsevier B.V. All rights rcserved C1 [Ge, Gaoming; Moghaddam, Davood Ghadiri; Simonson, Carey J.; Besant, Robert W.] Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada. [Mahmood, Gazi I.; Hanson, Stephen; Erb, Blake] Venmar CES Inc, Saskatoon, SK S7K 1V7, Canada. [Gibson, Phillip W.] US Army Soldier Syst Ctr, Natick, MA 01760 USA. RP Ge, GM (reprint author), Univ Saskatchewan, Dept Mech Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada. EM gag827@mail.usask.ca RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 FU Natural Science and Engineering Research Council of Canada (NSERC); Venmar CES, Inc., Saskatoon, SK, Canada FX This research was financially supported by the Natural Science and Engineering Research Council of Canada (NSERC) and Venmar CES, Inc., Saskatoon, SK, Canada. NR 37 TC 10 Z9 10 U1 3 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 EI 1873-3123 J9 J MEMBRANE SCI JI J. Membr. Sci. PD MAR 1 PY 2014 VL 453 BP 328 EP 336 DI 10.1016/j.memsci.2013.11.013 PG 9 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 295KE UT WOS:000330114200034 ER PT J AU Kowert, BA Watson, MB Dang, NC AF Kowert, Bruce A. Watson, Michael B. Dang, Nhan C. TI Diffusion of Squalene in n-Alkanes and Squalane SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; STOKES-EINSTEIN LAW; POLYATOMIC LIQUIDS; TRACER DIFFUSION; LIPID-BILAYER; MIXTURES; COEFFICIENT; RELAXATION; DEPENDENCE; HEXADECANE AB Squalene, an intermediate in the biosynthesis of cholesterol, has a 24-carbon backbone with six methyl groups and six isolated double bonds. Capillary flow techniques have been used to determine its translational diffusion constant, D, at room temperature in squalane, n-C-16, and three n-C-8-squalane mixtures. The D values have a weaker dependence on viscosity, eta, than predicted by the Stokes-Einstein relation, D = k(B)T/(6 pi eta r). A fit to the modified relation, D/T = A(SE)/eta(P), gives p = 0.820 +/- 0.028; p = 1 for the Stokes-Einstein limit. The translational motion of squalene appears to be much like that of n-alkane solutes with comparable chain lengths; their D values show similar deviations from the Stokes-Einstein model. The n-alkane with the same carbon chain length as squalene, n-C-24, has a near-equal p value of 0.844 +/- 0.018 in n-alkane solvents. The values of the hydrodynamic radius, r, for n-C-24, squalene, and other n-alkane solutes decrease as the viscosity increases and have a common dependence on the van der Waals volumes of the solute and solvent. The possibility of studying squalene in lipid droplets and membranes is discussed. C1 [Kowert, Bruce A.] St Louis Univ, Dept Chem, St Louis, MO 63103 USA. [Watson, Michael B.] Washington Univ, Dept Chem, St Louis, MO 63130 USA. [Dang, Nhan C.] US Army, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Kowert, BA (reprint author), St Louis Univ, Dept Chem, 3501 Laclede Ave, St Louis, MO 63103 USA. EM kowertba@slu.edu FU Department of Chemistry, Saint Louis University; Research Corp. FX The Department of Chemistry, Saint Louis University, supported this research. The data acquisition, system and detector were purchased with grants to Dr. Barry Hogan from Research Corp. and the donors of the Petroleum Research Fund, administered by the American Chemical Society. NR 58 TC 5 Z9 6 U1 3 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD FEB 27 PY 2014 VL 118 IS 8 BP 2157 EP 2163 DI 10.1021/jp411471r PG 7 WC Chemistry, Physical SC Chemistry GA AC0MB UT WOS:000332188300021 PM 24528091 ER PT J AU Valiyaveettil, M Alamneh, YA Wang, Y Arun, P Oguntayo, S Wei, YL Long, JB Nambiar, MP AF Valiyaveettil, Manoj Alamneh, Yonas A. Wang, Ying Arun, Peethambaran Oguntayo, Samuel Wei, Yanling Long, Joseph B. Nambiar, Madhusoodana P. TI Cytoskeletal protein alpha-II spectrin degradation in the brain of repeated blast exposed mice SO BRAIN RESEARCH LA English DT Article DE Cytoskeleton; alpha-II spectrin; Repeated blast exposure; Caspase-3; Calpain-2; Diffuse axonal injury; Traumatic brain injury ID TRAUMATIC AXONAL INJURY; CLOSED-HEAD INJURY; RAT-BRAIN; EXPLOSIVE BLAST; COGNITIVE DEFICITS; BREAKDOWN PRODUCTS; MOUSE MODEL; ENCEPHALOPATHY; MECHANISMS; CALPAIN AB Repeated blast exposures commonly induce traumatic brain injury (TBI) characterized by diffuse axonal injury (DAI). We hypothesized that degradation of cytoskeletal proteins in the brain can lead to DAI, and evaluated alpha-II spectrin degradation in the pathophysiology of blast-induced TBI using the tightly-coupled three repetitive blast exposure mice model with a 1-30 min window in between exposures. Degradation of alpha-II spectrin and the expression profiles of caspase-3 and calpain-2, the major enzymes involved in the degradation were analyzed in the frontal cortex and cerebellum using Western blotting with specific antibodies. DAI at different brain regions was evaluated by neuropathology with silver staining. Repeated blast exposures resulted in significant increases in the alpha-II spectrin degradation products in the frontal cortex and cerebellum compared to sham controls. Expression of active caspase-3, which degrades alpha-II spectrin, showed significant increase in the frontal cortex after blast exposure at all the time points studied, while cerebellum showed an acute increase which was normalized over time. The expression of another alpha-II spectrin degrading enzyme, calpain-2, showed a rapid increase in the frontal cortex after blast exposure and it was significantly higher in the cerebellum at later time points. Neuropathological analysis showed significant levels of DAI at the frontal cortex and cerebellum at multiple time points after repeated blast injury. In summary, repeated blast exposure results in specific degradation of alpha-II spectrin in the brain along with differential expression of caspase-3/calpain-2 suggesting cytoskeletal breakdown as a possible contributor of DAI after repeated blast exposure. (C) 2013 Elsevier B.V. All rights reserved. C1 [Valiyaveettil, Manoj; Alamneh, Yonas A.; Wang, Ying; Arun, Peethambaran; Oguntayo, Samuel; Wei, Yanling; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM m.valiyaveettil@us.army.mil; madhunambiar1@gmail.com NR 64 TC 4 Z9 4 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD FEB 26 PY 2014 VL 1549 BP 32 EP 41 DI 10.1016/j.brainres.2013.12.031 PG 10 WC Neurosciences SC Neurosciences & Neurology GA AD3MC UT WOS:000333142200004 PM 24412202 ER PT J AU Carter, R Hinojosa-Laborde, C Convertino, VA AF Carter, Robert, III Hinojosa-Laborde, Carmen Convertino, Victor A. TI Heart rate variability in patients being treated for dengue viral infection: new insights from mathematical correction of heart rate SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE dengue hemorrhagic fever; heart rate variability; high power frequency; parasympathetic nervous system; autonomic balance ID DIMINISHED PHYSIOLOGICAL RESERVE; 1,425 TRAUMA PATIENTS; PERIOD VARIABILITY; SYMPATHOVAGAL BALANCE; NEONATAL SEPSIS; MORTALITY; SPECTRUM; INDICATOR; TRIAGE AB Introduction: Severe dengue hemorrhagic fever (DHF) is a viral infection that acts to increase permeability of capillaries, resulting in internal hemorrhage. Linear frequency domain Fourier spectral analysis represents the most published noninvasive tool for diagnosing and assessing health status via calculated heart rate variability (HRV). As such, HRV may be useful in assessing clinical status in DHF patients, but is prone to erroneous results and conclusions due to the influence of the average HR during the time period of HRV assessment (defined as the "prevailing" HR). We tested the hypothesis that alterations in H RV calculated with linear frequency analysis would be minimal when mathematically corrected for prevailing HR following dengue viral infection. Methods: Male (N = 16) and female (N = 11) patients between the ages of 6 months and 15 years of age (10 +/- 6 SD years) were tracked through the progression of the dengue viral infection with treatment following the abatement of a fever (defervescence). Electrocardiographic recordings were collected and analyzed for HRV. Results: High frequency (HF), low frequency (LF), and LF/HF ratio were unaffected by correction for prevailing HR. Conclusion: HRV corrected for changes in HR did not alter the interpretation of our data. Therefore, we conclude that cardiac parasympathetic activity (based on HF frequency) is responsible for the majority of the HR reduction following defervescence in patients with dengue viral infection. C1 [Carter, Robert, III; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Carter, R (reprint author), US Army, Inst Surg Res, Div Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM robert.carter422.mil@mail.mil FU Telemedicine & Advanced Technology Research Center, Fort Detrick, Maryland FX The authors acknowledge the Dengue Hemorrhagic Fever Project Team at the Armed Forces Research Institute of Medical Sciences (AFRIMS) for data collection, the guidance and assistance of the medical staff at Queen Sirikit National Institute of Child Health, and the Telemedicine & Advanced Technology Research Center, Fort Detrick, Maryland for funding this effort. NR 33 TC 7 Z9 7 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD FEB 25 PY 2014 VL 5 AR 46 DI 10.3389/fphys.2014.00046 PG 4 WC Physiology SC Physiology GA AX3GS UT WOS:000346828800001 PM 24611050 ER PT J AU Cho, JH Lee, I Hammamieh, R Wang, K Baxter, D Scherler, K Etheridge, A Kulchenko, A Gautam, A Muhie, S Chakraborty, N Galas, DJ Jett, M Hood, L AF Cho, Ji-Hoon Lee, Inyoul Hammamieh, Rasha Wang, Kai Baxter, David Scherler, Kelsey Etheridge, Alton Kulchenko, Alena Gautam, Aarti Muhie, Seid Chakraborty, Nabarun Galas, David J. Jett, Marti Hood, Leroy TI Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE systems biology; transcriptome; microRNA ID ISCHEMIA-REPERFUSION INJURY; MESENCHYMAL TRANSITION; MYOCARDIAL-INFARCTION; TRANSCRIPTION; PROGRESSION; FIBROSIS; DISEASE; SKIN AB Posttraumatic stress disorder (PTSD) is a common condition induced by life-threatening stress, such as that experienced by soldiers under battlefield conditions. Other than the commonly recognized behavioral and psychological dysfunction, epidemiological studies have also revealed that PTSD patients have a higher risk of other diseases, such as cardiovascular disorders. Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation. Our results revealed acute heart injury associated with the traumatic experience, reflecting the underlying biological injury processes of the immune response, extracellular matrix remodeling, epithelial-to-mesenchymal cell transitions, and cell proliferation. Whether this type of injury has any long-term effects on heart function is yet to be determined. The differing responses to stress leading to acute heart injury in different inbred strains of mice also suggest that this response has a genetic as well as an environmental component. Accordingly, the results from this study suggest a molecular basis for the observed higher risk of cardiovascular disorders in PTSD patients, which raises the likelihood of cardiac dysfunction induced by long-term stress exposures. C1 [Cho, Ji-Hoon; Lee, Inyoul; Wang, Kai; Baxter, David; Scherler, Kelsey; Etheridge, Alton; Kulchenko, Alena; Hood, Leroy] Inst Syst Biol, Seattle, WA 98109 USA. [Hammamieh, Rasha; Gautam, Aarti; Muhie, Seid; Chakraborty, Nabarun; Jett, Marti] US Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [Galas, David J.] Pacific Northwest Diabet Res Inst, Seattle, WA 98122 USA. RP Hood, L (reprint author), Inst Syst Biol, Seattle, WA 98109 USA. EM lhood@systemsbiology.org FU Department of Defense [W911NF-09-D0001, W911SR-07-C0101]; Institute for Systems Biology-University of Luxembourg program FX We thank Bruz Marzolf, Pamela Troisch, Yue Yuan, and Sara McClarty at the Institute for Systems Biology for technical support. We also thank Linda Brennan, Julia Scheerer, and Duncan Donohue at the US Army Center for Environmental Health Research for editing the paper. This study is supported by Department of Defense Research Contracts W911NF-09-D0001 and W911SR-07-C0101 and the Institute for Systems Biology-University of Luxembourg program. NR 37 TC 12 Z9 12 U1 0 U2 20 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD FEB 25 PY 2014 VL 111 IS 8 BP 3188 EP 3193 DI 10.1073/pnas.1400113111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AC0JP UT WOS:000332180900065 PM 24516145 ER PT J AU Martins, KAO Steffens, JT van Tongeren, SA Wells, JB Bergeron, AA Dickson, SP Dye, JM Salazar, AM Bavari, S AF Martins, Karen A. O. Steffens, Jesse T. van Tongeren, Sean A. Wells, Jay B. Bergeron, Alison A. Dickson, Samuel P. Dye, John M. Salazar, Andres M. Bavari, Sina TI Toll-Like Receptor Agonist Augments Virus-Like Particle-Mediated Protection from Ebola Virus with Transient Immune Activation SO PLOS ONE LA English DT Article ID POLYRIBOINOSINIC-POLYRIBOCYTIDYLIC ACID; T-CELL RESPONSES; POLYINOSINIC-POLYCYTIDYLIC ACID; CANCER-STUDY-GROUP; PHASE-II TRIAL; POLY-L-LYSINE; NONHUMAN-PRIMATES; DENDRITIC CELLS; FILOVIRUS VACCINE; NEURO-BLASTOMA AB Identifying safe and effective adjuvants is critical for the advanced development of protein-based vaccines. Pattern recognition receptor (PRR) agonists are increasingly being explored as potential adjuvants, but there is concern that the efficacy of these molecules may be dependent on potentially dangerous levels of non-specific immune activation. The filovirus virus-like particle (VLP) vaccine protects mice, guinea pigs, and nonhuman primates from viral challenge. In this study, we explored the impact of a stabilized dsRNA mimic, polyICLC, on VLP vaccination of C57BL/6 mice and Hartley guinea pigs. We show that at dose levels as low as 100 ng, the adjuvant increased the efficacy of the vaccine in mice. Antigen-specific, polyfunctional CD4 and CD8 T cell responses and antibody responses increased significantly upon inclusion of adjuvant. To determine whether the efficacy of polyICLC correlated with systemic immune activation, we examined serum cytokine levels and cellular activation in the draining lymph node. PolyICLC administration was associated with increases in TNF alpha, IL6, MCP1, MIP1 alpha, KC, and MIP1 beta levels in the periphery and with the activation of dendritic cells (DCs), NK cells, and B cells. However, this activation resolved within 24 to 72 hours at efficacious adjuvant dose levels. These studies are the first to examine the polyICLC-induced enhancement of antigen-specific immune responses in the context of non-specific immune activation, and they provide a framework from which to consider adjuvant dose levels. C1 [Martins, Karen A. O.; Steffens, Jesse T.; van Tongeren, Sean A.; Wells, Jay B.; Bergeron, Alison A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Dye, John M.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD USA. [Dickson, Samuel P.] US Army Med Res Inst Infect Dis, Off Regulated Studies, Ft Detrick, MD USA. [Salazar, Andres M.] Oncovir Inc, Washington, DC USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM sina.bavari@us.army.mil FU Chemical-Biological Medical System-Joint Vaccine Acquisition Program (CBMS-JVAP); Defense Threat Reduction Agency (DTRA) [921159] FX Chemical-Biological Medical System-Joint Vaccine Acquisition Program (CBMS-JVAP) and Defense Threat Reduction Agency (DTRA) (Project 921159). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 19 Z9 19 U1 0 U2 26 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 24 PY 2014 VL 9 IS 2 AR e89735 DI 10.1371/journal.pone.0089735 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AB6EP UT WOS:000331880700079 PM 24586996 ER EF